ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd14j23 |
|---|---|
| Clone Library Name | barley_pub |
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 117 bits (292), Expect = 2e-26 Identities = 67/146 (45%), Positives = 92/146 (63%), Gaps = 8/146 (5%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNS--YKGVEQFANEV 267 F+YEEL+ AT GF +++G G F V+KG+LRDG+VVAVKR K S K ++F NE+ Sbjct: 493 FSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNEL 552 Query: 268 DILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM---LSWPT 438 D+LSRL H +L+ L G + LLVYEF+ +G+L HLH G DP + L+W Sbjct: 553 DLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLH-----GKDPNLKKRLNWAR 607 Query: 439 RLGIAVETAAALAYLHAH---QVLHR 507 R+ IAV+ A + YLH + V+HR Sbjct: 608 RVTIAVQAARGIEYLHGYACPPVIHR 633
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 106 bits (264), Expect = 4e-23 Identities = 67/162 (41%), Positives = 87/162 (53%), Gaps = 10/162 (6%) Frame = +1 Query: 52 RKEFNLAGSPCTHIF-------TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVA 210 RKE GS +F +Y++L +T+ F AN +G GGFG VYK L DG VA Sbjct: 701 RKELGEIGSKLVVLFQSNDKELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVA 760 Query: 211 VKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLH 390 +K+L + + +F EV+ LSR +HPNLV L G D LL+Y ++ NG+L LH Sbjct: 761 IKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLH 820 Query: 391 HGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA---HQVLHR 507 N G P +L W TRL IA A L YLH +LHR Sbjct: 821 ERNDG---PALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHR 859
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 104 bits (260), Expect = 1e-22 Identities = 59/144 (40%), Positives = 89/144 (61%), Gaps = 5/144 (3%) Frame = +1 Query: 91 IFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKN--SYKGVEQFANE 264 + + + L + T+ F + N LG+GGFG VYKG L DG+ +AVKR+ + KG +F +E Sbjct: 575 LISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSE 634 Query: 265 VDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRL 444 + +L+++RH +LV L G + LLVYE++P GTL+ HL + G PL+ W RL Sbjct: 635 IAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLL--WKQRL 692 Query: 445 GIAVETAAALAYLH--AHQ-VLHR 507 +A++ A + YLH AHQ +HR Sbjct: 693 TLALDVARGVEYLHGLAHQSFIHR 716
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 103 bits (257), Expect = 3e-22 Identities = 61/144 (42%), Positives = 84/144 (58%), Gaps = 6/144 (4%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 FT E ++ AT+ + +G GGFG+VY+G L DG VAVK S +G +F NE+++ Sbjct: 585 FTLEYIELATEKYKTL--IGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELNL 642 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPL---MLSWPTRL 444 LS ++H NLV L G + +LVY F+ NG+L D L+ G+P +L WPTRL Sbjct: 643 LSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLY------GEPAKRKILDWPTRL 696 Query: 445 GIAVETAAALAYLH---AHQVLHR 507 IA+ A LAYLH V+HR Sbjct: 697 SIALGAARGLAYLHTFPGRSVIHR 720
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 103 bits (256), Expect = 4e-22 Identities = 65/139 (46%), Positives = 76/139 (54%), Gaps = 1/139 (0%) Frame = +1 Query: 73 GSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVE 249 G H F + EL AAT F LG GGFG VYKG L G VVAVK+L +N +G Sbjct: 67 GQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNR 126 Query: 250 QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLS 429 +F EV +LS L HPNLV L G + LLVYEF+P G+L DHLH D L Sbjct: 127 EFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPP---DKEALD 183 Query: 430 WPTRLGIAVETAAALAYLH 486 W R+ IA A L +LH Sbjct: 184 WNMRMKIAAGAAKGLEFLH 202
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 103 bits (256), Expect = 4e-22 Identities = 56/136 (41%), Positives = 83/136 (61%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ +L AT+GF + +G+GGFG VYK L+DGSVVA+K+L S +G +F E++ + Sbjct: 877 TFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETI 936 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L D LH G + L+WP R IA+ Sbjct: 937 GKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTG---IKLNWPARRKIAI 993 Query: 457 ETAAALAYLHAHQVLH 504 A LA+LH + + H Sbjct: 994 GAARGLAFLHHNCIPH 1009
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 103 bits (256), Expect = 4e-22 Identities = 57/140 (40%), Positives = 86/140 (61%), Gaps = 3/140 (2%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ +L AT+GF + +G+GGFG VYK +L+DGS VA+K+L S +G +F E++ + Sbjct: 872 TFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETI 931 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYEF+ G+L D LH G + L+W TR IA+ Sbjct: 932 GKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAG---VKLNWSTRRKIAI 988 Query: 457 ETAAALAYLH---AHQVLHR 507 +A LA+LH + ++HR Sbjct: 989 GSARGLAFLHHNCSPHIIHR 1008
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 102 bits (255), Expect = 5e-22 Identities = 61/141 (43%), Positives = 83/141 (58%), Gaps = 3/141 (2%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 FT E ++ AT+ + +G GGFG+VY+G L DG VAVK S +G +F NE+++ Sbjct: 586 FTLEYIEQATEQYKTL--IGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNL 643 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 LS ++H NLV L G + +LVY F+ NG+L D L +G A +L WPTRL IA Sbjct: 644 LSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRL-YGEA--SKRKILDWPTRLSIA 700 Query: 454 VETAAALAYLH---AHQVLHR 507 + A LAYLH V+HR Sbjct: 701 LGAARGLAYLHTFPGRSVIHR 721
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 102 bits (254), Expect = 6e-22 Identities = 56/136 (41%), Positives = 83/136 (61%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ +L AT+GF + +G+GGFG VYK L+DGSVVA+K+L S +G +F E++ + Sbjct: 877 TFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETI 936 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L D LH G + L+WP R IA+ Sbjct: 937 GKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIG---IKLNWPARRKIAI 993 Query: 457 ETAAALAYLHAHQVLH 504 A LA+LH + + H Sbjct: 994 GAARGLAFLHHNCIPH 1009
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 100 bits (250), Expect = 2e-21 Identities = 55/136 (40%), Positives = 80/136 (58%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ L AT+GF A + +G+GGFG VYK L DGSVVA+K+L + + +G +F E++ + Sbjct: 847 TFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETI 906 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L LH GG + L W R IA+ Sbjct: 907 GKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGG--IFLDWSARKKIAI 964 Query: 457 ETAAALAYLHAHQVLH 504 A LA+LH + H Sbjct: 965 GAARGLAFLHHSCIPH 980
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 100 bits (249), Expect = 2e-21 Identities = 60/138 (43%), Positives = 79/138 (57%), Gaps = 3/138 (2%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +++ +T F AN +G GGFG VYK L DG+ VA+KRL ++ + +F EV+ LSR Sbjct: 734 DDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVETLSR 793 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 +HPNLV L G + D LL+Y ++ NG+L LH G P L W TRL IA Sbjct: 794 AQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDG---PPSLDWKTRLRIARGA 850 Query: 463 AAALAYLHAH---QVLHR 507 A LAYLH +LHR Sbjct: 851 AEGLAYLHQSCEPHILHR 868
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 100 bits (249), Expect = 2e-21 Identities = 55/136 (40%), Positives = 82/136 (60%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ L AT+GF A +G+GGFG VYK LRDGSVVA+K+L + + +G +F E++ + Sbjct: 848 TFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETI 907 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L LH ++ G + L+W R IA+ Sbjct: 908 GKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGG-IYLNWAARKKIAI 966 Query: 457 ETAAALAYLHAHQVLH 504 A LA+LH + H Sbjct: 967 GAARGLAFLHHSCIPH 982
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 100 bits (248), Expect = 3e-21 Identities = 56/138 (40%), Positives = 80/138 (57%), Gaps = 3/138 (2%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 E + AT+ F + N+LG GGFG VYKG L DG +AVKRL K S +G ++F NEV +++R Sbjct: 519 ETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIAR 578 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H NLV + GC + +L+YE++ N +L +L G L+W R I Sbjct: 579 LQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLF----GKTRRSKLNWNERFDITNGV 634 Query: 463 AAALAYLH---AHQVLHR 507 A L YLH +++HR Sbjct: 635 ARGLLYLHQDSRFRIIHR 652
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 100 bits (248), Expect = 3e-21 Identities = 59/132 (44%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVD 270 FT++EL AT F + LG GGFG V+KG + VVA+K+L +N +G+ +F EV Sbjct: 91 FTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVL 150 Query: 271 ILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGI 450 LS HPNLV L G + LLVYE++P G+L DHLH +G L W TR+ I Sbjct: 151 TLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSG---KKPLDWNTRMKI 207 Query: 451 AVETAAALAYLH 486 A A L YLH Sbjct: 208 AAGAARGLEYLH 219
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 99.4 bits (246), Expect = 5e-21 Identities = 62/158 (39%), Positives = 87/158 (55%), Gaps = 10/158 (6%) Frame = +1 Query: 43 TSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD--------- 195 T+ R E + SP FT+ EL AAT F + LG GGFG+V+KG + + Sbjct: 40 TNPRTEGEILQSPNLKSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPG 99 Query: 196 -GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGT 372 G V+AVK+L ++ ++G +++ EV+ L + HPNLV L G LLVYEF+P G+ Sbjct: 100 TGVVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGS 159 Query: 373 LADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 L +HL G LSW RL +A+ A LA+LH Sbjct: 160 LENHLFR---RGSYFQPLSWTLRLKVALGAAKGLAFLH 194
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 99.4 bits (246), Expect = 5e-21 Identities = 61/142 (42%), Positives = 82/142 (57%), Gaps = 4/142 (2%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVE-QFANEVD 270 F+ EL A+D F N LG GGFG VYKG L DG++VAVKRL + +G E QF EV+ Sbjct: 277 FSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVE 336 Query: 271 ILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGI 450 ++S H NL+ L G + + LLVY ++ NG++A L L WP R I Sbjct: 337 MISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPP---LDWPKRQRI 393 Query: 451 AVETAAALAYLHAH---QVLHR 507 A+ +A LAYLH H +++HR Sbjct: 394 ALGSARGLAYLHDHCDPKIIHR 415
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 99.0 bits (245), Expect = 7e-21 Identities = 55/135 (40%), Positives = 80/135 (59%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 + +L AT+GF AA+ +G GGFG V+K L+DGS VA+K+L + S +G +F E++ L Sbjct: 828 FSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLG 887 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 +++H NLV L G + LLVYEF+ G+L + L HG G +L W R IA Sbjct: 888 KIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVL-HGPRTGEKRRILGWEERKKIAKG 946 Query: 460 TAAALAYLHAHQVLH 504 A L +LH + + H Sbjct: 947 AAKGLCFLHHNCIPH 961
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 96.7 bits (239), Expect = 3e-20 Identities = 61/143 (42%), Positives = 81/143 (56%), Gaps = 10/143 (6%) Frame = +1 Query: 88 HIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQ----- 252 H + E + A D N +G G G VYK LR G VVAVK+L K+ G ++ Sbjct: 670 HKLHFSEHEIA-DCLDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDS 728 Query: 253 -----FANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDP 417 FA EV+ L +RH ++V L+ C SS LLVYE++PNG+LAD LH GG Sbjct: 729 LNRDVFAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGG--- 785 Query: 418 LMLSWPTRLGIAVETAAALAYLH 486 ++L WP RL IA++ A L+YLH Sbjct: 786 VVLGWPERLRIALDAAEGLSYLH 808
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 95.1 bits (235), Expect = 1e-19 Identities = 56/129 (43%), Positives = 75/129 (58%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPN 297 ATD F N +G GGFGTVYK L VAVK+L + +G +F E++ L +++HPN Sbjct: 913 ATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPN 972 Query: 298 LVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALA 477 LV+L G S + LLVYE++ NG+L DH G + +L W RL IAV A LA Sbjct: 973 LVSLLGYCSFSEEKLLVYEYMVNGSL-DHWLRNQTGMLE--VLDWSKRLKIAVGAARGLA 1029 Query: 478 YLHAHQVLH 504 +LH + H Sbjct: 1030 FLHHGFIPH 1038
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 94.7 bits (234), Expect = 1e-19 Identities = 58/153 (37%), Positives = 80/153 (52%), Gaps = 10/153 (6%) Frame = +1 Query: 67 LAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLR----------DGSVVAVK 216 L SP ++ + +L AT F + LG GGFG VY+G + G +VA+K Sbjct: 65 LLESPNLKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIK 124 Query: 217 RLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHG 396 RL S +G ++ +EV+ L L H NLV L G ++LLLVYEF+P G+L HL Sbjct: 125 RLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRR 184 Query: 397 NAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 N DP W R+ I + A LA+LH+ Q Sbjct: 185 N----DP--FPWDLRIKIVIGAARGLAFLHSLQ 211
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 90.9 bits (224), Expect = 2e-18 Identities = 60/136 (44%), Positives = 78/136 (57%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 ++Y EL AT F ELG G GTVYKGVL D VAVK+L +N +G E F E+ + Sbjct: 524 YSYRELVKATRKFKV--ELGRGESGTVYKGVLEDDRHVAVKKL-ENVRQGKEVFQAELSV 580 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 + R+ H NLV ++G S LLV E+V NG+LA+ L G ++L W R IA Sbjct: 581 IGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILF----SEGGNILLDWEGRFNIA 636 Query: 454 VETAAALAYLHAHQVL 501 + A LAYLH H+ L Sbjct: 637 LGVAKGLAYLH-HECL 651
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 89.7 bits (221), Expect = 4e-18 Identities = 52/131 (39%), Positives = 75/131 (57%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 F Y E+ T+ F +G GGFG VY GV+ +G VAVK L + S +G ++F EVD+ Sbjct: 564 FKYSEVVNITNNFERV--IGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDL 620 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 L R+ H NL +L G + ++L+YE++ N L D+L G +LSW RL I+ Sbjct: 621 LMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYL-----AGKRSFILSWEERLKIS 675 Query: 454 VETAAALAYLH 486 ++ A L YLH Sbjct: 676 LDAAQGLEYLH 686
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 89.0 bits (219), Expect = 7e-18 Identities = 58/160 (36%), Positives = 86/160 (53%), Gaps = 10/160 (6%) Frame = +1 Query: 46 SLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD---------- 195 S R E + SP F++ EL +AT F + LG GGFG V+KG + + Sbjct: 40 SPRTEGEILQSPNLKSFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGT 99 Query: 196 GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTL 375 G V+AVK+L ++ ++G +++ EV+ L + H +LV L G LLVYEF+P G+L Sbjct: 100 GLVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSL 159 Query: 376 ADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 +HL G LSW RL +A+ A LA+LH+ + Sbjct: 160 ENHLFR---RGLYFQPLSWKLRLKVALGAAKGLAFLHSSE 196
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 89.0 bits (219), Expect = 7e-18 Identities = 55/150 (36%), Positives = 85/150 (56%), Gaps = 10/150 (6%) Frame = +1 Query: 88 HIFTYEELDAATDGF------GAANELGAGGFGTVYKGVLRDGSVVAVKRLYK----NSY 237 H F++ EL + T+ F N +G GGFG VYKG + + ++VAVK+L ++ Sbjct: 166 HSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNN-TIVAVKKLGAMVEISTE 224 Query: 238 KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDP 417 + +QF E+ +++ +H NLV L G +S +L LVY ++PNG+L D L + G P Sbjct: 225 ELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRL---SCLDGTP 281 Query: 418 LMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 LSW TR +A TA + +LH + +HR Sbjct: 282 -PLSWHTRCKVAQGTANGIRFLHENHHIHR 310
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 88.6 bits (218), Expect = 9e-18 Identities = 56/131 (42%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +1 Query: 106 ELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNS---YKGVEQ-FANEVDI 273 E+ T F ++G GGFG VY+ V+R+ +V AVKRL +N+ + V+Q F EV+ Sbjct: 204 EISRGTHNFSEELKIGEGGFGCVYRAVMRN-TVYAVKRLKENADLEWTAVKQSFLTEVEQ 262 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 LSR RHPN+V G + LVY F+PNG+L D LH LSWP RL I Sbjct: 263 LSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP---LSWPQRLDIL 319 Query: 454 VETAAALAYLH 486 + TA A+ +LH Sbjct: 320 LGTARAIQFLH 330
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 87.0 bits (214), Expect = 3e-17 Identities = 57/150 (38%), Positives = 82/150 (54%), Gaps = 12/150 (8%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGS----------VVAVKRLYKNSYKG 243 F+ EL +AT F + +G GGFG V+KG + + S V+AVKRL + ++G Sbjct: 56 FSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQG 115 Query: 244 VEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM 423 ++ E++ L +L HPNLV L G LLVYEF+ G+L +HL G Sbjct: 116 HREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFR---RGTFYQP 172 Query: 424 LSWPTRLGIAVETAAALAYLH--AHQVLHR 507 LSW TR+ +A+ A LA+LH QV++R Sbjct: 173 LSWNTRVRMALGAARGLAFLHNAQPQVIYR 202
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 85.5 bits (210), Expect = 8e-17 Identities = 58/155 (37%), Positives = 82/155 (52%), Gaps = 4/155 (2%) Frame = +1 Query: 34 SPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 SP++ L++ P + + E+ T F +G GGFG VY+ V+R+ + AV Sbjct: 185 SPVSGLQR-----AHPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRN-TTYAV 238 Query: 214 KRLYKNS---YKGVEQ-FANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLAD 381 KRL + + + V+Q F EV+ LSR RHPN+V G + LVY F+PNG+L D Sbjct: 239 KRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLED 298 Query: 382 HLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 LH LSWP RL I + TA A+ +LH Sbjct: 299 QLHLQTQACSP---LSWPQRLDILLGTARAIQFLH 330
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 84.0 bits (206), Expect = 2e-16 Identities = 55/150 (36%), Positives = 82/150 (54%), Gaps = 10/150 (6%) Frame = +1 Query: 88 HIFTYEELDAATDGFG------AANELGAGGFGTVYKGVLRDGSVVAVKRLYK----NSY 237 H F++ EL T+ F N++G GGFG VYKG + + + VAVK+L + Sbjct: 166 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNN-TTVAVKKLAAMVDITTE 224 Query: 238 KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDP 417 + +QF E+ ++++ +H NLV L G +S DL LVY ++PNG+L D L + G P Sbjct: 225 ELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRL---SCLDGTP 281 Query: 418 LMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 LSW R IA A + +LH + +HR Sbjct: 282 -PLSWHMRCKIAQGAANGINFLHENHHIHR 310
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 82.4 bits (202), Expect = 6e-16 Identities = 59/176 (33%), Positives = 93/176 (52%), Gaps = 8/176 (4%) Frame = +1 Query: 4 ASLDGLIREGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDG----FGAANELGAGGFGT 171 A++ GLI + + K+ N S + +++LD ++ N +G GG G Sbjct: 647 AAITGLILISVAIRQMNKKKNQK-SLAWKLTAFQKLDFKSEDVLECLKEENIIGKGGAGI 705 Query: 172 VYKGVLRDGSVVAVKRLY-KNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLV 348 VY+G + + VA+KRL + + + F E+ L R+RH ++V L G ++ LL+ Sbjct: 706 VYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVANKDTNLLL 765 Query: 349 YEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH---AHQVLHR 507 YE++PNG+L + L HG+ GG L W TR +AVE A L YLH + +LHR Sbjct: 766 YEYMPNGSLGE-LLHGSKGG----HLQWETRHRVAVEAAKGLCYLHHDCSPLILHR 816
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 75.5 bits (184), Expect = 8e-14 Identities = 45/137 (32%), Positives = 70/137 (51%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T + + + D +LGAG FG VY+G+ + + VAVK L + + F E I+ Sbjct: 84 TKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAA-FLAEAQIM 142 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +LRHP L+ LY + + ++ E + G+L D+L G AG L P + +A Sbjct: 143 KKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYL-QGEAGA-----LKLPQLIDMAA 196 Query: 457 ETAAALAYLHAHQVLHR 507 + AA +AYL H +HR Sbjct: 197 QVAAGMAYLELHNYIHR 213
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 73.9 bits (180), Expect = 2e-13 Identities = 49/134 (36%), Positives = 69/134 (51%), Gaps = 5/134 (3%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKN---SYKGVE--QFANE 264 Y EL+ ATDG+ N LG GGFG VY+G + V Y++ K VE Q NE Sbjct: 203 YAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNE 262 Query: 265 VDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRL 444 + L+ +RH N++ALYG + LVY+ + G+L L A P L+W R Sbjct: 263 LKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLP-ALTWQQRF 321 Query: 445 GIAVETAAALAYLH 486 I++ TA + +LH Sbjct: 322 SISLGTARGIYFLH 335
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 72.8 bits (177), Expect = 5e-13 Identities = 46/124 (37%), Positives = 61/124 (49%), Gaps = 1/124 (0%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK-GVEQFANEVDILSRLRHP 294 AT+ +G G GT+YK L V AVK+L K G E++ + ++RH Sbjct: 812 ATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRHR 871 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 NL+ L L++Y ++ NG+L D LH N P L W TR IAV TA L Sbjct: 872 NLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNP----PKPLDWSTRHNIAVGTAHGL 927 Query: 475 AYLH 486 AYLH Sbjct: 928 AYLH 931
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 71.2 bits (173), Expect = 1e-12 Identities = 47/131 (35%), Positives = 62/131 (47%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHP 294 A D F A ++GAG F VYK R V V ++ K EV +++RLRHP Sbjct: 47 ARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLP-SNRSNTLREVQLMNRLRHP 105 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N++ G L + E++ GTL L P LSWP RL +A++ A L Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL-------SSPEPLSWPVRLHLALDIAQGL 158 Query: 475 AYLHAHQVLHR 507 YLHA V HR Sbjct: 159 RYLHAKGVFHR 169
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 71.2 bits (173), Expect = 1e-12 Identities = 47/131 (35%), Positives = 62/131 (47%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHP 294 A D F A ++GAG F VYK R V V ++ K EV +++RLRHP Sbjct: 47 ARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLP-SNRSNTLREVQLMNRLRHP 105 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N++ G L + E++ GTL L P LSWP RL +A++ A L Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL-------SSPEPLSWPVRLHLALDIAQGL 158 Query: 475 AYLHAHQVLHR 507 YLHA V HR Sbjct: 159 RYLHAKGVFHR 169
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 70.9 bits (172), Expect = 2e-12 Identities = 42/121 (34%), Positives = 66/121 (54%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ GV + + VAVK L K F +E ++ +LRH +LV LY S Sbjct: 245 KLGAGQFGEVWAGVWNNTTQVAVKTL-KPGTMSPASFLDEAGVMKKLRHKHLVQLYAICS 303 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D+L G+ + L PT + +A + A+ +A+L A +H Sbjct: 304 DREPIYIVTEYMSGGSLLDYL-----SKGEGVNLQLPTLIDMAAQVASGMAFLEAQGYIH 358 Query: 505 R 507 R Sbjct: 359 R 359
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 70.5 bits (171), Expect = 3e-12 Identities = 48/132 (36%), Positives = 65/132 (49%), Gaps = 1/132 (0%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYK-NSYKGVEQFANEVDILSRLRH 291 A D F A ++GAG F VYK R V V ++ K S +G EV +++RLRH Sbjct: 52 ARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRG--NTLREVQLMNRLRH 109 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ G L + E++ GTL L P LSWP RL +A++ A Sbjct: 110 PNILRFMGVCVHQGQLHALTEYMNGGTLEQLL-------SSPEPLSWPVRLHLALDIARG 162 Query: 472 LAYLHAHQVLHR 507 L YLH+ V HR Sbjct: 163 LRYLHSKGVFHR 174
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 68.9 bits (167), Expect = 7e-12 Identities = 49/158 (31%), Positives = 72/158 (45%), Gaps = 2/158 (1%) Frame = +1 Query: 40 LTSLRKEFNLAGS--PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 ++ LR L GS P T F+YE+ + E+G+G FG V+ G R VA+ Sbjct: 239 ISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAI 298 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + S E F E ++ +L H LV LYG + L +V EF+ NG L D+L Sbjct: 299 KAINEGSMSE-EDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRE 357 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L+LS + + +AYL +HR Sbjct: 358 RKGQLQKALLLS------MCQDICEGMAYLERSCYIHR 389
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 68.9 bits (167), Expect = 7e-12 Identities = 39/123 (31%), Positives = 65/123 (52%), Gaps = 2/123 (1%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG+G FG V +G R GS+ ++ K + F E ++++L+HPNLV LYG S Sbjct: 531 ELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCS 589 Query: 325 SCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 R + +V E++ +G+L ++L H G L+L + ++ + + YL H Sbjct: 590 KHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLD------MCIQVSKGMTYLERHNY 643 Query: 499 LHR 507 +HR Sbjct: 644 IHR 646
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 68.6 bits (166), Expect = 1e-11 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 3/156 (1%) Frame = +1 Query: 49 LRKEFNLAGSPCTHIFTYE---ELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKR 219 L + + A P T +Y+ E+D T +LG G FG V+ GV + VAVK Sbjct: 38 LSRPCSRANIPITSGLSYKDEWEIDRTT--IQLQRKLGQGNFGEVWAGVWNGTTAVAVKT 95 Query: 220 LYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 L ++ + V+ F E ++ ++ HPNL+ LY + + +V E + G++ ++L HG Sbjct: 96 LKPDTME-VKDFVQEAQVMKKIHHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGE 154 Query: 400 AGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ + ++ + A+ + YL AH +HR Sbjct: 155 GKN-----ITLHQMVDMSAQIASGMTYLEAHSYIHR 185
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 68.2 bits (165), Expect = 1e-11 Identities = 47/158 (29%), Positives = 72/158 (45%), Gaps = 2/158 (1%) Frame = +1 Query: 40 LTSLRKEFNLAGS--PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 +T LR L GS P T F+YE+ + E+G+G FG V+ G R VA+ Sbjct: 239 MTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAI 298 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + S E F E ++ +L H LV LYG + L +V EF+ NG L ++L Sbjct: 299 KAINEGSMSE-EDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE 357 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++LS + + + YL + +HR Sbjct: 358 NKGKLRKEMLLS------VCQDICEGMEYLERNGYIHR 389
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 68.2 bits (165), Expect = 1e-11 Identities = 39/120 (32%), Positives = 63/120 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LGAG FG V++G+ + VAVK L K +E+F E I+ +LRHP L+ LY + Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTL-KPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTK 304 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E + +G+L ++L GD L P + + + A+ ++YL +HR Sbjct: 305 EEPIYIVTELMKHGSLLEYLR------GDGRSLKLPDLVDMCSQVASGMSYLEQQNYIHR 358
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 67.4 bits (163), Expect = 2e-11 Identities = 40/120 (33%), Positives = 63/120 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LGAG FG V++G+ + VAVK L K VE+F E I+ RLRHP L+ LY + Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTL-KPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCTK 304 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E + G+L ++L G+ +L + +A + A+ ++YL +HR Sbjct: 305 EEPIYIVTELMKYGSLLEYLR------GEDGVLKIEQLVDVAAQVASGMSYLEQQNYIHR 358
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 67.0 bits (162), Expect = 3e-11 Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 5/126 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 ELG G FG VYKG L + VA+K L +N S K + F E++++S L+H N+V + Sbjct: 415 ELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCI 474 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G + +++E++ NG L + L + G LS L IA++ + + YL A Sbjct: 475 LGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGK--SLSQLEFLQIALQISEGMQYLSA 532 Query: 490 HQVLHR 507 H +HR Sbjct: 533 HHYVHR 538
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 66.6 bits (161), Expect = 4e-11 Identities = 38/121 (31%), Positives = 63/121 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 E+G+G FG V+ G + VA+K + + + E F E +++ +L HP LV LYG Sbjct: 373 EIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSE-EDFIEEAEVMMKLSHPKLVQLYGVCL 431 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + LV+EF+ +G L+D+L + + T LG+ ++ +AYL V+H Sbjct: 432 EQAPICLVFEFMEHGCLSDYLRSQRG------LFAAETLLGMCLDVCEGMAYLEKACVIH 485 Query: 505 R 507 R Sbjct: 486 R 486
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 66.6 bits (161), Expect = 4e-11 Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 5/123 (4%) Frame = +1 Query: 154 AGGFGTVYKGV-LRDGSVVAVKRLYKNSYKG----VEQFANEVDILSRLRHPNLVALYGC 318 +G FG VY GV + G ++AVK + + V+Q NE+ +L RL HPN+V YG Sbjct: 1045 SGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGV 1104 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + + EF G+LAD L HG + L + V+ LAY+H+ + Sbjct: 1105 EVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKV-------YVVQLLEGLAYIHSQHI 1157 Query: 499 LHR 507 LHR Sbjct: 1158 LHR 1160
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 66.6 bits (161), Expect = 4e-11 Identities = 46/139 (33%), Positives = 69/139 (49%), Gaps = 4/139 (2%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKG--VEQFANEVDIL 276 +++D ++GAG FGTV++ GS VAVK L + + V +F EV I+ Sbjct: 542 DDMDIPWCDLNIKEKIGAGSFGTVHRAEWH-GSDVAVKILMEQDFHAERVNEFLREVAIM 600 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 RLRHPN+V G + +L +V E++ G+L LH A L RL +A Sbjct: 601 KRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGARE----QLDERRRLSMAY 656 Query: 457 ETAAALAYLHAHQ--VLHR 507 + A + YLH ++HR Sbjct: 657 DVAKGMNYLHNRNPPIVHR 675
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 65.9 bits (159), Expect = 6e-11 Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 5/159 (3%) Frame = +1 Query: 43 TSLRKEFNLAGSPCTHIFTYE-ELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKR 219 TS+ K+ L +F E ++ ATD F ++ G F VY+G R G K+ Sbjct: 180 TSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGH-RHGKPFVFKK 238 Query: 220 LYK---NSYKGVEQFAN-EVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL 387 L + +S +E+F E+ I R HPN++ + G ++ + +Y ++ NG+L D L Sbjct: 239 LRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRL 298 Query: 388 HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 GG DP L WP R+ I A+ YLH +++H Sbjct: 299 Q--GQGGSDP--LPWPQRVSICSGLLCAVEYLHGLEIIH 333
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 65.9 bits (159), Expect = 6e-11 Identities = 38/121 (31%), Positives = 63/121 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 E+G+G FG V+ G + VA+K + + + E F E +++ +L HP LV LYG Sbjct: 368 EIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSE-EDFIEEAEVMMKLSHPKLVQLYGVCL 426 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + LV+EF+ +G L+D+L + + T LG+ ++ +AYL V+H Sbjct: 427 EQAPICLVFEFMEHGCLSDYLRTQRG------LFAAETLLGMCLDVCEGMAYLEEACVIH 480 Query: 505 R 507 R Sbjct: 481 R 481
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 65.5 bits (158), Expect = 8e-11 Identities = 41/121 (33%), Positives = 61/121 (50%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G R+ VAVK L + + F E I+ + RH LVALY S Sbjct: 289 KLGRGNFGEVFYGKWRNSIDVAVKTLREGTMS-TAAFLQEAAIMKKFRHNRLVALYAVCS 347 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L GD L + + IA + A+ + YL + Q++H Sbjct: 348 QEEPIYIVQEYMSKGSLLDFLRE-----GDGRYLHFEDLIYIATQVASGMEYLESKQLIH 402 Query: 505 R 507 R Sbjct: 403 R 403
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 65.5 bits (158), Expect = 8e-11 Identities = 43/126 (34%), Positives = 65/126 (51%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP +V G Sbjct: 468 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 526 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA-- 489 C +V +++ G+L LH +L ++L IAV+ A + YLH+ Sbjct: 527 CLDDPSQFAIVTQYISGGSLFSLLHE------QKRILDLQSKLIIAVDVAKGMEYLHSLT 580 Query: 490 HQVLHR 507 ++HR Sbjct: 581 QPIIHR 586
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 65.5 bits (158), Expect = 8e-11 Identities = 43/126 (34%), Positives = 65/126 (51%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP +V G Sbjct: 467 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 525 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA-- 489 C +V +++ G+L LH +L ++L IAV+ A + YLH+ Sbjct: 526 CLDDPSQFAIVTQYISGGSLFSLLHE------QKRILDLQSKLIIAVDVAKGMEYLHSLT 579 Query: 490 HQVLHR 507 ++HR Sbjct: 580 QPIIHR 585
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 65.1 bits (157), Expect = 1e-10 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP ++ G Sbjct: 468 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 526 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH--A 489 C + +V +++ G+L LH +L ++L IAV+ A + YLH Sbjct: 527 CLNDPSQFAIVTQYISGGSLFSLLHE------QKRILDLQSKLIIAVDVARGMEYLHNLT 580 Query: 490 HQVLHR 507 ++HR Sbjct: 581 QPIIHR 586
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 65.1 bits (157), Expect = 1e-10 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP ++ G Sbjct: 570 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 628 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH--A 489 C + +V +++ G+L LH +L ++L IAV+ A + YLH Sbjct: 629 CLNDPSQFAIVTQYISGGSLFSLLHE------QKRILDLQSKLIIAVDVAKGMEYLHNLT 682 Query: 490 HQVLHR 507 ++HR Sbjct: 683 QPIIHR 688
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 64.7 bits (156), Expect = 1e-10 Identities = 37/136 (27%), Positives = 66/136 (48%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 181 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 240 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N + ++L L +A + Sbjct: 241 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL-----LYMATQ 295 Query: 460 TAAALAYLHAHQVLHR 507 ++A+ YL +HR Sbjct: 296 ISSAMEYLEKKNFIHR 311
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 64.7 bits (156), Expect = 1e-10 Identities = 37/136 (27%), Positives = 66/136 (48%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N + ++L L +A + Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL-----LYMATQ 346 Query: 460 TAAALAYLHAHQVLHR 507 ++A+ YL +HR Sbjct: 347 ISSAMEYLEKKNFIHR 362
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/122 (30%), Positives = 61/122 (50%) Frame = +1 Query: 142 NELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 ++LG G +G VY GV + S+ + K VE+F E ++ ++HPNLV L G Sbjct: 292 HKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 351 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 + +V E++P G L D+L N ++L L +A + ++A+ YL + Sbjct: 352 TLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL-----LYMATQISSAMEYLEKKNFI 406 Query: 502 HR 507 HR Sbjct: 407 HR 408
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/136 (27%), Positives = 65/136 (47%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N ++L L +A + Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVL-----LYMATQ 346 Query: 460 TAAALAYLHAHQVLHR 507 ++A+ YL +HR Sbjct: 347 ISSAMEYLEKKNFIHR 362
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/136 (27%), Positives = 65/136 (47%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 118 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 177 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N ++L L +A + Sbjct: 178 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVL-----LYMATQ 232 Query: 460 TAAALAYLHAHQVLHR 507 ++A+ YL +HR Sbjct: 233 ISSAMEYLEKKNFIHR 248
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/123 (31%), Positives = 64/123 (52%), Gaps = 2/123 (1%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 +LG G FG V+K R G V+ +K L++ + F EV +L L H +++ G Sbjct: 406 KLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVL 465 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPL-MLSWPTRLGIAVETAAALAYLHAHQV 498 + L +V E+V G L + +H DP +L WP R+ +A + A ++YLH+ + Sbjct: 466 YKDKKLHMVTEYVAGGCLKELIH-------DPAQVLPWPQRVRLARDIACGMSYLHSMNI 518 Query: 499 LHR 507 +HR Sbjct: 519 IHR 521
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 63.9 bits (154), Expect = 2e-10 Identities = 44/121 (36%), Positives = 58/121 (47%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VAVK L K E F E I+ RLRH LV LY S Sbjct: 274 KLGNGQFGEVWMGTWNGTTKVAVKTL-KPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVS 332 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + AA +AY+ +H Sbjct: 333 E-EPIYIVTEFMSQGSLLDFLKDG-----DGRYLKLPQLVDMAAQIAAGMAYIERMNYIH 386 Query: 505 R 507 R Sbjct: 387 R 387
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 63.5 bits (153), Expect = 3e-10 Identities = 44/132 (33%), Positives = 63/132 (47%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 D F LG G FG VY L++ +VA+K L+K+ + G+E Q E++I + L+H Sbjct: 41 DDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQH 100 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LY R + L+ E+ P G L L L I E A A Sbjct: 101 PNILRLYNYFHDARRVYLILEYAPRGELYKELQKSE-------KLDEQRTATIIEELADA 153 Query: 472 LAYLHAHQVLHR 507 L Y H +V+HR Sbjct: 154 LTYCHDKKVIHR 165
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 63.2 bits (152), Expect = 4e-10 Identities = 37/121 (30%), Positives = 65/121 (53%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG+G FG V++G+ + + VA+K L K+ + F E I+ +LRH L+ LY + Sbjct: 253 KLGSGQFGDVWEGLWNNTTPVAIKTL-KSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCT 311 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ E + +G+L ++L A G L T + +A + AA +AYL + +H Sbjct: 312 VEEPIYIITELMKHGSLLEYL---QAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIH 368 Query: 505 R 507 R Sbjct: 369 R 369
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 62.0 bits (149), Expect = 9e-10 Identities = 41/122 (33%), Positives = 62/122 (50%), Gaps = 1/122 (0%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG+G FG V G + VAVK + + S ++F E + +L HP LV YG S Sbjct: 422 ELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSE-DEFFQEAQTMMKLSHPKLVKFYGVCS 480 Query: 325 SCRDLLLVYEFVPNGTLADHLH-HGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 + +V E++ NG L ++L HG G +P L L + + +A+L +HQ + Sbjct: 481 KEYPIYIVTEYISNGCLLNYLRSHGK--GLEPSQL-----LEMCYDVCEGMAFLESHQFI 533 Query: 502 HR 507 HR Sbjct: 534 HR 535
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 62.0 bits (149), Expect = 9e-10 Identities = 40/123 (32%), Positives = 63/123 (51%), Gaps = 1/123 (0%) Frame = +1 Query: 142 NELGAGGFGTVYKGVL-RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 ++LG G +G VY+ V R G+ VAVK L K ++ F E I+ ++HPNLV L G Sbjct: 375 HKLGGGQYGEVYEAVWKRYGNTVAVKTL-KEDTMALKDFLEEAAIMKEMKHPNLVQLIGV 433 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + ++ EF+ +G L D L D + L L +A + A+ ++YL + Sbjct: 434 CTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVAL-----LYMATQIASGMSYLESRNY 488 Query: 499 LHR 507 +HR Sbjct: 489 IHR 491
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/130 (35%), Positives = 62/130 (47%), Gaps = 4/130 (3%) Frame = +1 Query: 130 FGAANELGAGGFGTVY-KGVLRDGSVVAVKRLYKNS---YKGVEQFANEVDILSRLRHPN 297 F LG G FG VY + G V A+K + K Y +QF EV+I S LRHPN Sbjct: 109 FEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPN 168 Query: 298 LVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALA 477 L LYG + + L+ E++ NG L HL G + D + + + A AL Sbjct: 169 LTQLYGYFHDEKRVYLLMEYLVNGELYKHL-KGRSHFNDVVASYY------VYQMADALD 221 Query: 478 YLHAHQVLHR 507 Y+H +LHR Sbjct: 222 YMHERNILHR 231
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/121 (33%), Positives = 60/121 (49%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVE-QFANEVDILSRLRHPNLVALYGCTS 324 LG G FG VYKG L+D + VAVK ++ + ++ +F E IL + HPN+V L G + Sbjct: 70 LGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 129 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + + ++ E VP G L D L L R +++ AA + YL +H Sbjct: 130 QRQPVYIIMELVPGGDFLSFLRKRK----DELKLKQLVR--FSLDVAAGMLYLEGKNCIH 183 Query: 505 R 507 R Sbjct: 184 R 184
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/126 (33%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSV----VAVKRLYKNS-YKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + +G VA+K L + + K +F +E I++ + HP+LV L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G S + LV + +P+G L +++H G L+L+W V+ A + YL Sbjct: 784 LGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW------CVQIAKGMMYLEE 836 Query: 490 HQVLHR 507 +++HR Sbjct: 837 RRLVHR 842
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/112 (36%), Positives = 57/112 (50%), Gaps = 1/112 (0%) Frame = +1 Query: 163 FGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCR-DL 339 +GTVYK L DG +A++ L + + K + L R+RH NLV L R + Sbjct: 384 YGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEK 443 Query: 340 LLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 LL+Y+++PN +L D LH L+W R IA+ A LAYLH Q Sbjct: 444 LLIYDYLPNISLHDLLHESKP---RKPALNWARRHKIALGIARGLAYLHTGQ 492
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 61.2 bits (147), Expect = 2e-09 Identities = 52/160 (32%), Positives = 72/160 (45%), Gaps = 5/160 (3%) Frame = +1 Query: 43 TSLRK-EFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGV-LRDGSVVAVK 216 +SLRK E +AG P + + E F LG G FG VY + G +VA+K Sbjct: 61 SSLRKIEEPIAGVPSSAGPQWREFHIGM--FEIGKPLGKGKFGRVYLAKEKKTGFIVALK 118 Query: 217 RLYKNSY---KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL 387 L+K+ K +Q E++I S LRH N++ LYG + + L+ EF G L HL Sbjct: 119 TLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHL 178 Query: 388 HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 S + A AL+YLH V+HR Sbjct: 179 RRAK-------RFSEEVASKYIFQMANALSYLHKKHVIHR 211
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/144 (29%), Positives = 63/144 (43%) Frame = +1 Query: 76 SPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQF 255 +P T + + A D +LG G F V+ G + VA+K L K E F Sbjct: 249 TPQTSGLAKDAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTL-KPGTMSPESF 307 Query: 256 ANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWP 435 E I+ +L+H LV LY S + +V E++ G+L D L G L P Sbjct: 308 LEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRA-----LKLP 361 Query: 436 TRLGIAVETAAALAYLHAHQVLHR 507 + +A + AA +AY+ +HR Sbjct: 362 NLVDMAAQVAAGMAYIERMNYIHR 385
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/120 (34%), Positives = 56/120 (46%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VAVK L K E F E I+ +LRH LV LY S Sbjct: 276 LGNGQFGEVWMGTWNGTTKVAVKTL-KPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE 334 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E++ G+L D L G L P + +A + AA +AY+ +HR Sbjct: 335 -EPIYIVTEYMSKGSLLDFLKDGEGRA-----LKLPNLVDMAAQVAAGMAYIERMNYIHR 388
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/126 (33%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSV----VAVKRLYKNS-YKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + +G VA+K L + + K +F +E I++ + HP+LV L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRL 783 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G S + LV + +P+G L +++H G L+L+W V+ A + YL Sbjct: 784 LGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW------CVQIAKGMMYLEE 836 Query: 490 HQVLHR 507 +++HR Sbjct: 837 RRLVHR 842
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/121 (31%), Positives = 60/121 (49%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ G + + VAVK L K V+ F E +++ L+H LV LY + Sbjct: 251 KLGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVT 309 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ EF+ G+L D L GG L+ P + + + A +AY+ +H Sbjct: 310 KEEPIYIITEFMAKGSLLDFLKSDE--GGKVLL---PKLIDFSAQIAEGMAYIERKNYIH 364 Query: 505 R 507 R Sbjct: 365 R 365
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 60.8 bits (146), Expect = 2e-09 Identities = 40/124 (32%), Positives = 72/124 (58%), Gaps = 4/124 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLY-KNSYKGVEQ-FANEVDILSRLRHPNLVALYGCT 321 LG GG+G VYK + + G+ VAVK + K+ K +E+ F EV I++ LRHPN+V + Sbjct: 792 LGTGGYGEVYKSIWK-GTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM--LSWPTRLGIAVETAAALAYLHAHQ 495 + ++ +V EF+ G+L D L G+ L+ + + ++ +A + + + +LH+ Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLL-------GNELIPEIPYALKIKMAYQASKGMHFLHSSG 903 Query: 496 VLHR 507 ++HR Sbjct: 904 IVHR 907 Score = 51.2 bits (121), Expect = 2e-06 Identities = 38/153 (24%), Positives = 70/153 (45%), Gaps = 4/153 (2%) Frame = +1 Query: 61 FNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK 240 F + + C I Y+E+ ++G G +G V+ G + G VAVK+ K Sbjct: 1348 FLTSANMCRWIINYDEISIG-------KQIGLGSYGIVFNGKWK-GVDVAVKKFVKQKLS 1399 Query: 241 GVE--QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGD 414 + +F E+ LS L+H N+V G ++ +V E++ G L D L + + Sbjct: 1400 ETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPD----- 1454 Query: 415 PLMLSWPTRLGIAVETAAALAYLHAH--QVLHR 507 + +++ +L + A + YLH+ ++HR Sbjct: 1455 -IKITFANKLKLLYGAAMGIDYLHSSNPMIVHR 1486
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 60.8 bits (146), Expect = 2e-09 Identities = 45/135 (33%), Positives = 67/135 (49%), Gaps = 14/135 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + S + F E ++L+ L+H ++V Sbjct: 515 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVR 574 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGD--PLMLSWPTRLGIAVET 462 +G + R LL+V+E++ +G L L HG AGG D P L L +A + Sbjct: 575 FFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 634 Query: 463 AAALAYLHAHQVLHR 507 AA + YL +HR Sbjct: 635 AAGMVYLAGLHFVHR 649
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 60.5 bits (145), Expect = 3e-09 Identities = 41/115 (35%), Positives = 62/115 (53%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ++G G +G V K V RD +VAVK + ++ + + EV LSR++HPN++AL+G +S Sbjct: 24 KVGHGSYGVVCKAVWRD-KLVAVKEFFASAEQ--KDIEKEVKQLSRVKHPNIIALHGISS 80 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 + L+ EF G+L + LH G S + A + A LAYLHA Sbjct: 81 YQQATYLIMEFAEGGSLHNFLH-----GKVKPAYSLAHAMSWARQCAEGLAYLHA 130
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 60.5 bits (145), Expect = 3e-09 Identities = 34/136 (25%), Positives = 69/136 (50%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 +++ + + F +LG+G FG V++G+ +D VA+K + +++ + +E+ + Sbjct: 181 WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK 240 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 +LRH +++ALY S + ++ E + G+L + L D +L L IA + Sbjct: 241 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLR-----DSDEKVLPVSELLDIAWQ 295 Query: 460 TAAALAYLHAHQVLHR 507 A + YL + +HR Sbjct: 296 VAEGMCYLESQNYIHR 311
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/132 (30%), Positives = 60/132 (45%) Frame = +1 Query: 112 DAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRH 291 + A D +LG G F V++G + VA+K L K E F E I+ +L+H Sbjct: 261 EVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKH 319 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 LV LY S R + +V E++ G+L L G L P + +A + AA Sbjct: 320 DKLVQLYAVVSR-RPIYIVTEYMSKGSLLIFLKDGEGRA-----LKLPNLVDMAAQVAAG 373 Query: 472 LAYLHAHQVLHR 507 +AY+ +HR Sbjct: 374 MAYIERMNYIHR 385
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 60.1 bits (144), Expect = 3e-09 Identities = 39/120 (32%), Positives = 56/120 (46%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VA+K L K E F E I+ +L+H LV LY S Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE 334 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E++ G+L D L G L P + +A + AA +AY+ +HR Sbjct: 335 -EPIYIVTEYMNKGSLLDFLKDGEGRA-----LKLPNLVDMAAQVAAGMAYIERMNYIHR 388
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 60.1 bits (144), Expect = 3e-09 Identities = 44/158 (27%), Positives = 72/158 (45%), Gaps = 2/158 (1%) Frame = +1 Query: 40 LTSLRKEFNLAG--SPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 +T LR ++ G +P T F+YE+ + ELG+G FG V G R VA+ Sbjct: 338 VTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAI 397 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + + E F E ++ +L HP LV LYG + + + +V EF+ G L + L Sbjct: 398 KAIREGAMCE-EDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ 456 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++LS + + + YL + +HR Sbjct: 457 RQGHFSRDVLLS------MCQDVCEGMEYLERNSFIHR 488
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 59.7 bits (143), Expect = 4e-09 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 12/133 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HG-----NAGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 603 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 662 Query: 469 ALAYLHAHQVLHR 507 + YL + +HR Sbjct: 663 GMVYLASQHFVHR 675
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 59.7 bits (143), Expect = 4e-09 Identities = 47/128 (36%), Positives = 70/128 (54%), Gaps = 8/128 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK---GVEQFANEVDILSRLRHPNLVALYG- 315 +G G FG V +G R+ V A+K +Y++ +K + F NEV ILS+LRHPN+V G Sbjct: 1295 IGKGFFGEVKRGYWRETDV-AIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGA 1353 Query: 316 CTSSCRD-LLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH- 486 CT+ D +V E++ G+L L H N +P + RL +A++ A + YLH Sbjct: 1354 CTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHI-----RLKLALDIAKGMNYLHG 1408 Query: 487 -AHQVLHR 507 +LHR Sbjct: 1409 WTPPILHR 1416
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 59.7 bits (143), Expect = 4e-09 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 12/133 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HG-----NAGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 661 Query: 469 ALAYLHAHQVLHR 507 + YL + +HR Sbjct: 662 GMVYLASQHFVHR 674
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 59.7 bits (143), Expect = 4e-09 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 12/133 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HG-----NAGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 661 Query: 469 ALAYLHAHQVLHR 507 + YL + +HR Sbjct: 662 GMVYLASQHFVHR 674
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 59.7 bits (143), Expect = 4e-09 Identities = 37/137 (27%), Positives = 69/137 (50%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T ++ + + LG+G FG V++G+ + + VAVK L K F E I+ Sbjct: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTL-KPGSMDPNDFLREAQIM 281 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 LRHP L+ LY + + ++ E + +G+L ++L + G + L+ ++ +A Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDT---GSKIHLT--QQVDMAA 336 Query: 457 ETAAALAYLHAHQVLHR 507 + A+ +AYL + +HR Sbjct: 337 QVASGMAYLESRNYIHR 353
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 59.3 bits (142), Expect = 6e-09 Identities = 44/134 (32%), Positives = 63/134 (47%), Gaps = 4/134 (2%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRL 285 A + F LG G FG VY + ++A+K L+K + GVE Q EV+I S L Sbjct: 129 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188 Query: 286 RHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETA 465 RHPN++ LYG + L+ E+ P GT+ L + E A Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS-------KFDEQRTATYITELA 241 Query: 466 AALAYLHAHQVLHR 507 AL+Y H+ +V+HR Sbjct: 242 NALSYCHSKRVIHR 255
>ATG1_KLULA (Q6CSX2) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 831 Score = 59.3 bits (142), Expect = 6e-09 Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 4/89 (4%) Frame = +1 Query: 121 TDGFGAANELGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKG---VEQFANEVDILSRLR 288 T+ + E+G G F VYKG+ LRDG +A+K + ++ K +E E+ IL +++ Sbjct: 18 TENYSVEKEIGKGSFAVVYKGLSLRDGRNIAIKAVSRSKLKNKKLLENLEVEIAILKKIK 77 Query: 289 HPNLVALYGCTSSCRDLLLVYEFVPNGTL 375 HP++V L C + D L+ E+ G L Sbjct: 78 HPHIVGLIDCERTSSDFYLIMEYCALGDL 106
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 59.3 bits (142), Expect = 6e-09 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 12/133 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 539 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 598 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HG-----NAGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 599 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAA 658 Query: 469 ALAYLHAHQVLHR 507 + YL + +HR Sbjct: 659 GMVYLASQHFVHR 671
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 59.3 bits (142), Expect = 6e-09 Identities = 41/121 (33%), Positives = 57/121 (47%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 281 KLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 339 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + A +AY+ +H Sbjct: 340 E-EPIYIVTEFMSKGSLLDFLKEG-----DGKYLKLPQLVDMAAQIADGMAYIERMNYIH 393 Query: 505 R 507 R Sbjct: 394 R 394
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 59.3 bits (142), Expect = 6e-09 Identities = 41/121 (33%), Positives = 57/121 (47%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 279 KLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 337 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + A +AY+ +H Sbjct: 338 E-EPIYIVTEFMSKGSLLDFLKEG-----DGKYLKLPQLVDMAAQIADGMAYIERMNYIH 391 Query: 505 R 507 R Sbjct: 392 R 392
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 59.3 bits (142), Expect = 6e-09 Identities = 37/120 (30%), Positives = 59/120 (49%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LGAG FG V+ G + + VAVK L K V+ F E +++ L+H LV LY + Sbjct: 252 LGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTR 310 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + ++ E++ G+L D L GG L+ P + + + A +AY+ +HR Sbjct: 311 EEPIYIITEYMAKGSLLDFLKSDE--GGKVLL---PKLIDFSAQIAEGMAYIERKNYIHR 365
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 59.3 bits (142), Expect = 6e-09 Identities = 41/129 (31%), Positives = 67/129 (51%), Gaps = 3/129 (2%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYK--NSYKGVEQFANEVDILSRLRHPNL 300 + ++ +G G FG VYK +D S VVA+K + K + K ++ E DI +RL+HP++ Sbjct: 4 YAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHV 63 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 + + S DL +V EF L +L + A G +P + +AL Y Sbjct: 64 IEMIESFESKTDLFVVTEFALM-DLHRYLSYNGAMGEEPAR-------RVTGHLVSALYY 115 Query: 481 LHAHQVLHR 507 LH++++LHR Sbjct: 116 LHSNRILHR 124
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 58.9 bits (141), Expect = 8e-09 Identities = 52/163 (31%), Positives = 74/163 (45%), Gaps = 18/163 (11%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGSV--- 204 GSP I FTYE+ + A F + +GAG FG VYKG L+ S Sbjct: 588 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREI 647 Query: 205 -VAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 648 SVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 707 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L N G + L +G+ AA + YL +HR Sbjct: 708 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLSEMNYVHR 744
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 58.9 bits (141), Expect = 8e-09 Identities = 51/163 (31%), Positives = 73/163 (44%), Gaps = 4/163 (2%) Frame = +1 Query: 31 GSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGS-VV 207 G LT + L GS FT D F LG G FG VY + +V Sbjct: 54 GQKLTENKGATALQGSQSRQPFTI-------DNFEIGRPLGKGKFGNVYLAREKKSRFIV 106 Query: 208 AVKRLYKNSYK--GVE-QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 A+K L+K+ + GVE Q E++I + L+HPN++ LY + + L+ E+ P G L Sbjct: 107 ALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELY 166 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +G D + I E + AL Y H +V+HR Sbjct: 167 KELQ--KSGTFDEQRTA-----TIMEELSDALMYCHKKKVIHR 202
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 58.9 bits (141), Expect = 8e-09 Identities = 38/129 (29%), Positives = 66/129 (51%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLY--------KNSYKGVEQFANEVDILSRLRHPNL 300 +G G FGTVY G+ L G ++AVK++ + + +++ EV +L L HPN+ Sbjct: 74 IGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 133 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V G L ++ EFVP G+++ L A + ++ ++ +L + +E Y Sbjct: 134 VRYLGTVREDETLNILLEFVPGGSISSLLEKFGA-FPESVVRTYTNQLLLGLE------Y 186 Query: 481 LHAHQVLHR 507 LH H ++HR Sbjct: 187 LHNHAIMHR 195
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 58.9 bits (141), Expect = 8e-09 Identities = 41/121 (33%), Positives = 57/121 (47%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 277 KLGQGCFGEVWMGTWNGTTKVAIKTL-KLGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 335 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + A +AY+ +H Sbjct: 336 E-EPIYIVTEFMSKGSLLDFLKEG-----DGKYLKLPQLVDMAAQIADGMAYIERMNYIH 389 Query: 505 R 507 R Sbjct: 390 R 390
>ROR2_HUMAN (Q01974) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Length = 943 Score = 58.9 bits (141), Expect = 8e-09 Identities = 43/138 (31%), Positives = 68/138 (49%), Gaps = 17/138 (12%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGV--EQFANEVDILSRLRHPNL 300 ELG FG VYKG L VA+K L K+ +G E+F +E + +RL+HPN+ Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTL-KDKAEGPLREEFRHEAMLRARLQHPNV 536 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAGGGD-----PLMLSWPTRLGIA 453 V L G + + L +++ + +G L + L H + G D L P + + Sbjct: 537 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLV 596 Query: 454 VETAAALAYLHAHQVLHR 507 + AA + YL +H V+H+ Sbjct: 597 AQIAAGMEYLSSHHVVHK 614
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 58.9 bits (141), Expect = 8e-09 Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 14/135 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + S + F E ++L+ L+H ++V Sbjct: 518 ELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVR 577 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGD--PLMLSWPTRLGIAVET 462 +G + LL+V+E++ +G L L HG AGG D P L L +A + Sbjct: 578 FFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 637 Query: 463 AAALAYLHAHQVLHR 507 AA + YL + +HR Sbjct: 638 AAGMVYLASLHFVHR 652
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 58.9 bits (141), Expect = 8e-09 Identities = 50/155 (32%), Positives = 70/155 (45%), Gaps = 7/155 (4%) Frame = +1 Query: 64 NLAGSPCTHIFTYEELDAATDGFGAANE-------LGAGGFGTVYKGVLRDGSVVAVKRL 222 NL +PCT I + L A D + + LG G FG V+ G + VAVK L Sbjct: 235 NLLIAPCT-IMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTL 293 Query: 223 YKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNA 402 K + F E ++ LRH LV LY S + +V EF+ +G+L D L N Sbjct: 294 -KPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLK--NP 349 Query: 403 GGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G D L P + +A + A +AY+ +HR Sbjct: 350 EGQD---LRLPQLVDMAAQVAEGMAYMERMNYIHR 381
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 58.9 bits (141), Expect = 8e-09 Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 + F LG G FG VY R+ ++A+K L+K+ + GVE Q EV+I S LRH Sbjct: 138 EDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRH 197 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ ++ P G L L L + A A Sbjct: 198 PNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAL-------YIKQLAEA 250 Query: 472 LAYLHAHQVLHR 507 L Y H+ +V+HR Sbjct: 251 LLYCHSKKVIHR 262
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 58.9 bits (141), Expect = 8e-09 Identities = 52/163 (31%), Positives = 74/163 (45%), Gaps = 18/163 (11%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGSV--- 204 GSP I FTYE+ + A F + +GAG FG VYKG L+ S Sbjct: 505 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREI 564 Query: 205 -VAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 565 SVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 624 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L N G + L +G+ AA + YL +HR Sbjct: 625 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLSEMNYVHR 661
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 58.9 bits (141), Expect = 8e-09 Identities = 36/121 (29%), Positives = 60/121 (49%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ G + + VAVK L K + F E +++ L+H LV LY + Sbjct: 251 KLGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVT 309 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ EF+ G+L D L + G ++L P + + + A +AY+ +H Sbjct: 310 KEEPIYIITEFMAKGSLLDFL---KSDEGSKVLL--PKLIDFSAQIAEGMAYIERKNYIH 364 Query: 505 R 507 R Sbjct: 365 R 365
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 58.5 bits (140), Expect = 1e-08 Identities = 38/121 (31%), Positives = 56/121 (46%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG G FG V G + VAVK + K ++F E + +L HP LV YG S Sbjct: 398 ELGNGQFGVVQLGQWKGQYDVAVKMI-KEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCS 456 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ NG L ++L G L L + + +A+L +HQ +H Sbjct: 457 KKYPIYIVTEYITNGCLLNYLKSHGKG------LESCQLLEMCYDVCEGMAFLESHQFIH 510 Query: 505 R 507 R Sbjct: 511 R 511
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 58.5 bits (140), Expect = 1e-08 Identities = 39/123 (31%), Positives = 62/123 (50%), Gaps = 1/123 (0%) Frame = +1 Query: 142 NELGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 N+LG G +G VY+G R +AVK L K + +F E I+ L H NLV L G Sbjct: 315 NKLGGGQYGDVYEGYWKRHDCTIAVKAL-KEDAMPLHEFLAEAAIMKDLHHKNLVRLLGV 373 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + ++ EF+ NG L ++L + P++L + +A + A+ ++YL A Sbjct: 374 CTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIIL-----VQMASQIASGMSYLEARHF 428 Query: 499 LHR 507 +HR Sbjct: 429 IHR 431
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 58.5 bits (140), Expect = 1e-08 Identities = 38/120 (31%), Positives = 55/120 (45%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VA+K L K E F E I+ +L+H LV LY S Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE 334 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E++ G+L D L G L P + +A + A +AY+ +HR Sbjct: 335 -EPIYIVTEYMSKGSLLDFLKDGEGRA-----LKLPNLVDMAAQVARGMAYIERMNYIHR 388
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 58.5 bits (140), Expect = 1e-08 Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 2/158 (1%) Frame = +1 Query: 40 LTSLRKEFNLAG--SPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 +T LR + G +P T F+Y++ + ELG+G FG V G R VA+ Sbjct: 337 VTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAI 396 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + + E F E ++ +L HP LV LYG + + + +V EF+ G L + L Sbjct: 397 KAIREGAMCE-EDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ 455 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++LS + + + YL + +HR Sbjct: 456 RQGHFSRDMLLS------MCQDVCEGMEYLERNSFIHR 487
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/135 (29%), Positives = 64/135 (47%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + F +LG G FG V++G+ VAVK + K++ + E++ L Sbjct: 225 DEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVK-VIKSADMKLADLTKEIEALKS 283 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 LRH L+ L+ S + +V E + G L +L G + LS P LG A + Sbjct: 284 LRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYL-----GSSEGKALSLPHLLGFACQV 338 Query: 463 AAALAYLHAHQVLHR 507 A ++YL +V+HR Sbjct: 339 AEGMSYLEERRVVHR 353
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 58.5 bits (140), Expect = 1e-08 Identities = 42/129 (32%), Positives = 59/129 (45%), Gaps = 3/129 (2%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGS--VVAVKRLYK-NSYKGVEQFANEVDILSRLRHPNL 300 F + +G G F V+KG R+ VAVK + K N K E+ IL L+H N+ Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 VALY + LV E+ G LAD+LH D + L + A A+ Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRL-------FLQQIAGAMRL 128 Query: 481 LHAHQVLHR 507 LH+ ++HR Sbjct: 129 LHSKGIIHR 137
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 + F LG G FG VY R+ ++A+K L+K+ + GVE Q EV+I S LRH Sbjct: 138 EDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRH 197 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ ++ P G L L + + A A Sbjct: 198 PNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAM-------YIKQLAEA 250 Query: 472 LAYLHAHQVLHR 507 L Y H+ +V+HR Sbjct: 251 LLYCHSKKVIHR 262
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/132 (31%), Positives = 59/132 (44%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYKGVE---QFANEVDILSRLRH 291 + F LG G FG VY R ++A+K L+K + Q EV+I S LRH Sbjct: 122 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRH 181 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ E+ P GT+ L + E A A Sbjct: 182 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS-------KFDEQRTATYITELANA 234 Query: 472 LAYLHAHQVLHR 507 L+Y H+ +V+HR Sbjct: 235 LSYCHSKRVIHR 246
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/121 (33%), Positives = 56/121 (46%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 279 KLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 337 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G L P + +A + A +AY+ +H Sbjct: 338 E-EPIYIVTEFMTKGSLLDFLKEGEGK-----FLKLPQLVDMAAQIADGMAYIERMNYIH 391 Query: 505 R 507 R Sbjct: 392 R 392
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/129 (32%), Positives = 59/129 (45%), Gaps = 3/129 (2%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGS--VVAVKRLYK-NSYKGVEQFANEVDILSRLRHPNL 300 F + +G G F V+KG R+ VAVK + K N K E+ IL L+H N+ Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 VALY + LV E+ G LAD+LH D + L + A A+ Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRL-------FLQQIAGAMRL 128 Query: 481 LHAHQVLHR 507 LH+ ++HR Sbjct: 129 LHSKGIIHR 137
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L + DP W ++ A A+ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLRN-----ADP--FPWQQKVSFAKGIASGMAYLHSMCIIH 449 Query: 505 R 507 R Sbjct: 450 R 450
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 + F LG G FG VY + ++A+K L+K + GVE Q EV+I S LRH Sbjct: 124 EDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRH 183 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ E+ P GT+ L + E A A Sbjct: 184 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS-------KFDEQRTATYITELANA 236 Query: 472 LAYLHAHQVLHR 507 L+Y H+ +V+HR Sbjct: 237 LSYCHSKRVIHR 248
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 57.8 bits (138), Expect = 2e-08 Identities = 35/123 (28%), Positives = 60/123 (48%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 27 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 86 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 87 MTK-DNLAIVTQWCEGSSLYKHLH------VQETKFQMFQLIDIARQTAQGMDYLHAKNI 139 Query: 499 LHR 507 +HR Sbjct: 140 IHR 142
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 57.8 bits (138), Expect = 2e-08 Identities = 42/138 (30%), Positives = 67/138 (48%), Gaps = 17/138 (12%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLR-----DGSVVAVKRL--YKNSYKGVEQFANEVDILSRLRHPNLV 303 ELG FG +YKG L +VA+K L Y N + +E F E +++ L HPN+V Sbjct: 478 ELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWME-FQQEASLMAELHHPNIV 536 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAG------GGDPLMLSWPTRLGIA 453 L G + + + +++E++ G L + L H + G G L L IA Sbjct: 537 CLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIA 596 Query: 454 VETAAALAYLHAHQVLHR 507 ++ AA + YL +H +H+ Sbjct: 597 IQIAAGMEYLSSHFFVHK 614
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 57.8 bits (138), Expect = 2e-08 Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVE-QFANEVDILSRLRHPNLVALYGCTS 324 LG G FG VYKG L+D + VAVK ++ + ++ +F E IL + HPN+V L G + Sbjct: 569 LGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 628 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + + ++ E V G L D L L + +++ AA + YL + +H Sbjct: 629 QRQPVYIIMELVSGGDFLTFLRRKK----DELKLKQLVK--FSLDAAAGMLYLESKNCIH 682 Query: 505 R 507 R Sbjct: 683 R 683
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 57.8 bits (138), Expect = 2e-08 Identities = 43/132 (32%), Positives = 59/132 (44%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 D F LG G FG VY + +VA+K L+K+ + GVE Q E++I + L H Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LY R + L+ E+ P G L L I E A A Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKS-------CTFDEQRTATIMEELADA 187 Query: 472 LAYLHAHQVLHR 507 L Y H +V+HR Sbjct: 188 LMYCHGKKVIHR 199
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 57.8 bits (138), Expect = 2e-08 Identities = 40/121 (33%), Positives = 56/121 (46%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 272 KLGQGCFGEVWMGTWNGTTKVAIKTL-KLGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 330 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G L P + +A + A +AY+ +H Sbjct: 331 E-EPIYIVTEFMTKGSLLDFLKEGEGK-----FLKLPQLVDMAAQIADGMAYIERMNYIH 384 Query: 505 R 507 R Sbjct: 385 R 385
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 57.8 bits (138), Expect = 2e-08 Identities = 51/163 (31%), Positives = 73/163 (44%), Gaps = 18/163 (11%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGS---- 201 GSP I FTYE+ + A F + +GAG FG VYKG L+ Sbjct: 587 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREI 646 Query: 202 VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 647 YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L N G + L +G+ AA + YL +HR Sbjct: 707 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLSEMNYVHR 743
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.8 bits (138), Expect = 2e-08 Identities = 35/123 (28%), Positives = 60/123 (48%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 412 MTK-DNLAIVTQWCEGSSLYKHLH------VQETKFQMFQLIDIARQTAQGMDYLHAKNI 464 Query: 499 LHR 507 +HR Sbjct: 465 IHR 467
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.8 bits (138), Expect = 2e-08 Identities = 35/123 (28%), Positives = 60/123 (48%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 412 MTK-DNLAIVTQWCEGSSLYKHLH------VQETKFQMFQLIDIARQTAQGMDYLHAKNI 464 Query: 499 LHR 507 +HR Sbjct: 465 IHR 467
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 57.8 bits (138), Expect = 2e-08 Identities = 37/135 (27%), Positives = 63/135 (46%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + +LGAG FG V+ G + VA+K L K F E +++ Sbjct: 234 DEWEVPRESLKLVEKLGAGQFGEVWMGFYNGHTKVAIKNL-KQGSMSPSAFLAEANLMKN 292 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+HP LV LY + + ++ E++ G+L D L + + LS L +A + Sbjct: 293 LQHPRLVRLYAVVTK-EPIYIITEYMEKGSLVDFLK-----TSEGIKLSINKLLDMAAQI 346 Query: 463 AAALAYLHAHQVLHR 507 A +A++ A +HR Sbjct: 347 AEGMAFIEAKNYIHR 361
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 57.4 bits (137), Expect = 2e-08 Identities = 40/121 (33%), Positives = 57/121 (47%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 275 KLGQGCFGEVWIGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 333 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L GN L P + +A + A +AY+ +H Sbjct: 334 E-EPIYIVTEYMIKGSLLDFLKEGNGK-----YLKLPQLVDMAAQIADGMAYIERMNYIH 387 Query: 505 R 507 R Sbjct: 388 R 388
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 57.4 bits (137), Expect = 2e-08 Identities = 41/127 (32%), Positives = 68/127 (53%), Gaps = 7/127 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKNS-YKGVEQFANEVDILSRLRHPNLVAL 309 LG G FG VYKGV + +G VA+K L K++ + E+F E I++ H NL+ L Sbjct: 944 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKL 1003 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 C SS ++L+ + +P G L D++ + G +L+W T++ A ++YL Sbjct: 1004 LAVCMSS--QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQI------AKGMSYLE 1055 Query: 487 AHQVLHR 507 +++HR Sbjct: 1056 EKRLVHR 1062
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.4 bits (137), Expect = 2e-08 Identities = 41/161 (25%), Positives = 75/161 (46%) Frame = +1 Query: 25 REGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSV 204 RE +P++ +++ + Y E++A+ + +G+G FGTVYKG Sbjct: 316 RERAPVSGTQEKNKIRPRGQRDSSYYWEIEASE--VMLSTRIGSGSFGTVYKGKWHGDVA 373 Query: 205 VAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADH 384 V + ++ + + + F NEV +L + RH N++ G + +L +V ++ +L H Sbjct: 374 VKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKH 432 Query: 385 LHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 LH + IA +TA + YLHA ++HR Sbjct: 433 LH------VQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR 467
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 57.4 bits (137), Expect = 2e-08 Identities = 51/163 (31%), Positives = 73/163 (44%), Gaps = 18/163 (11%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGS---- 201 GSP I FTYE+ + A F + +GAG FG VYKG L+ Sbjct: 587 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREI 646 Query: 202 VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 647 YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L N G + L +G+ AA + YL +HR Sbjct: 707 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLAEMNYVHR 743
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 57.4 bits (137), Expect = 2e-08 Identities = 51/163 (31%), Positives = 73/163 (44%), Gaps = 18/163 (11%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGS---- 201 GSP I FTYE+ + A F + +GAG FG VYKG L+ Sbjct: 587 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREI 646 Query: 202 VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 647 YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L N G + L +G+ AA + YL +HR Sbjct: 707 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLAEMNYVHR 743
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 57.4 bits (137), Expect = 2e-08 Identities = 42/161 (26%), Positives = 75/161 (46%) Frame = +1 Query: 25 REGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSV 204 RE +P T+ +++ + Y E++A+ + +G+G FGTVYKG Sbjct: 316 RERAPGTNTQEKNKIRPRGQRDSSYYWEIEASE--VMLSTRIGSGSFGTVYKGKWHGDVA 373 Query: 205 VAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADH 384 V + ++ + + + F NEV +L + RH N++ G + +L +V ++ +L H Sbjct: 374 VKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKH 432 Query: 385 LHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 LH + IA +TA + YLHA ++HR Sbjct: 433 LH------VQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR 467
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 57.4 bits (137), Expect = 2e-08 Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 3/123 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYK--NSYKGVEQFANEVDILSRLRHPNLVALYGC 318 +G G FG VYKG + VVA+K + K S K + E++I+ LRHPN+V + Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDS 69 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +++++V ++ G L L D + IA + +AL YLH+H++ Sbjct: 70 FETDKEVVVVTDYA-EGELLQILEDDGKLPEDQVQ-------AIAAQLVSALYYLHSHRI 121 Query: 499 LHR 507 LHR Sbjct: 122 LHR 124
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 57.0 bits (136), Expect = 3e-08 Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 2/135 (1%) Frame = +1 Query: 109 LDAATDGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFA-NEVDILSR 282 + ++ F +LG G + TVYKG R +G +VA+K + +S +G A E+ ++ Sbjct: 1 MTGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIREISLMKE 60 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L H N+V LY + L LV+EF+ HGN G D ++ + Sbjct: 61 LDHENIVTLYDVIHTENKLTLVFEFMDKDLKKYMEAHGNQGALDLKIVK-----SFIFQL 115 Query: 463 AAALAYLHAHQVLHR 507 + + H ++VLHR Sbjct: 116 LKGIMFCHDNRVLHR 130
>CHK2_CAEEL (Q9U1Y5) Serine/threonine-protein kinase chk-2 (EC 2.7.11.1)| (Ce-cds-1) (Ce-chk-2) Length = 476 Score = 57.0 bits (136), Expect = 3e-08 Identities = 47/163 (28%), Positives = 71/163 (43%), Gaps = 18/163 (11%) Frame = +1 Query: 73 GSPCTHIFTYEELDA-------ATDGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLY- 225 G P IF YE DA ++ LG GGFG V G + D SVVA+K+L Sbjct: 144 GIPALIIFVYESADADHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNT 203 Query: 226 ------KNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL 387 + NEV+++ +L HPN+VA+Y + + +V E+V G + Sbjct: 204 QFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKV 263 Query: 388 ---HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + G G+ L + A + A+ YLH+ + HR Sbjct: 264 VDSKYNRMGLGESLGKYF------AFQLIDAILYLHSVGICHR 300
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 57.0 bits (136), Expect = 3e-08 Identities = 35/123 (28%), Positives = 59/123 (47%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + + F NEV +L + RH N++ G Sbjct: 85 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 144 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 145 MTK-DNLAIVTQWCEGSSLYKHLH------VQETKFQMFQLIDIARQTAQGMDYLHAKNI 197 Query: 499 LHR 507 +HR Sbjct: 198 IHR 200
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 57.0 bits (136), Expect = 3e-08 Identities = 41/132 (31%), Positives = 60/132 (45%), Gaps = 4/132 (3%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 D F LG G FG VY + +VA+K L+K+ + GVE Q E++I + L+H Sbjct: 80 DNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKH 139 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LY + + L+ E+ P G L L I E + A Sbjct: 140 PNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRT-------FDEQRTATIMEELSDA 192 Query: 472 LAYLHAHQVLHR 507 L Y H +V+HR Sbjct: 193 LTYCHKKKVIHR 204
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 57.0 bits (136), Expect = 3e-08 Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + + ++ W R+ A + A+ +AYLH+ ++H Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKNMDS------QYPWSQRVSFAKDIASGMAYLHSMNIIH 458 Query: 505 R 507 R Sbjct: 459 R 459
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 57.0 bits (136), Expect = 3e-08 Identities = 37/135 (27%), Positives = 64/135 (47%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G + VAVK L K + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSL-KQGSMSPDAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+HP LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSG-----IKLNVNKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHR 507 A +A++ +HR Sbjct: 348 AEGMAFIEEQNYIHR 362
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 57.0 bits (136), Expect = 3e-08 Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 3/123 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYK--NSYKGVEQFANEVDILSRLRHPNLVALYGC 318 +G G FG VYKG + VVA+K + K S K + E++I+ LRHPN+V + Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDS 69 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +++++V ++ G L L D + IA + +AL YLH+H++ Sbjct: 70 FETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQ-------AIAAQLVSALYYLHSHRI 121 Query: 499 LHR 507 LHR Sbjct: 122 LHR 124
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 57.0 bits (136), Expect = 3e-08 Identities = 40/141 (28%), Positives = 68/141 (48%), Gaps = 6/141 (4%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGV------EQFANE 264 EE A N+ +G +Y+G+ + +V AVK + ++K +QF +E Sbjct: 77 EEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAV-AVKMVRIPTHKEETRAKLEQQFKSE 135 Query: 265 VDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRL 444 V +LSRL HPN+V ++ E++ G L +L+ +P LS T L Sbjct: 136 VALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNK-----KEPYSLSIETVL 190 Query: 445 GIAVETAAALAYLHAHQVLHR 507 +A++ + + YLH+ V+HR Sbjct: 191 RLALDISRGMEYLHSQGVIHR 211
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 7/121 (5%) Frame = +1 Query: 145 ELGAGGFGTVYK---GVLRD--GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 +LG G FG+V L+D G VVAVK+L ++ + + F E++IL L+H N+V Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 310 YGCTSSC--RDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 G S R+L L+ E++P G+L D+L +L + +++ +E Y+ Sbjct: 914 KGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYI 973 Query: 484 H 486 H Sbjct: 974 H 974 Score = 47.4 bits (111), Expect = 2e-05 Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD--------GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLV 303 LG G F ++KGV R+ + V +K L K E F ++S+L H +LV Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 YG + +LV EFV G+L +L + + + W +LG+A + A A+ +L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNK----NSINILW--KLGVAKQLAWAMHFL 664 Query: 484 HAHQVLH 504 ++H Sbjct: 665 EEKSLIH 671
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 56.6 bits (135), Expect = 4e-08 Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLY--------KNSYKGVEQFANEVDILSRLRHPNL 300 +G G FGTVY G+ L G ++AVK++ + + +++ EV +L L HPN+ Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 134 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V G L ++ EFVP G+++ L G ++ TR + L Y Sbjct: 135 VRYLGTVREDDTLNILLEFVPGGSISSLLE--KFGPFPESVVRTYTR-----QLLLGLEY 187 Query: 481 LHAHQVLHR 507 LH H ++HR Sbjct: 188 LHNHAIMHR 196
>ROR2_MOUSE (Q9Z138) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2) Length = 944 Score = 56.6 bits (135), Expect = 4e-08 Identities = 42/138 (30%), Positives = 66/138 (47%), Gaps = 17/138 (12%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGV--EQFANEVDILSRLRHPNL 300 ELG FG VYKG L VA+K L K+ +G E+F E + +RL+HPN+ Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTL-KDKAEGPLREEFRQEAMLRARLQHPNI 536 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAGGGD-----PLMLSWPTRLGIA 453 V L G + + L +++ + +G L + L H + G D L P + + Sbjct: 537 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVV 596 Query: 454 VETAAALAYLHAHQVLHR 507 + AA + +L +H V H+ Sbjct: 597 AQIAAGMEFLSSHHVCHK 614
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 56.6 bits (135), Expect = 4e-08 Identities = 42/129 (32%), Positives = 68/129 (52%), Gaps = 3/129 (2%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHPNL 300 + +LG G +G V K R+ G +VA+KR+ +S +GV A E+ +L L+HPN+ Sbjct: 4 YSKIEKLGEGTYGIVNKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNI 63 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V L+ + R L LV+E++ D + + GG+ +S PT + +A+ Sbjct: 64 VRLHDVIHTERKLTLVFEYLDQ----DLKKYLDECGGE---ISKPTIKSFMYQLLKGVAF 116 Query: 481 LHAHQVLHR 507 H H+VLHR Sbjct: 117 CHDHRVLHR 125
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 56.6 bits (135), Expect = 4e-08 Identities = 35/123 (28%), Positives = 62/123 (50%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 ++ +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 343 SSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 402 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + + IA +TA + YLHA + Sbjct: 403 MTK-DNLAIVTQWCEGSSLYYHLHVLDT------KFQMFQLIDIARQTAQGMDYLHAKNI 455 Query: 499 LHR 507 +HR Sbjct: 456 IHR 458
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 56.6 bits (135), Expect = 4e-08 Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK R+ G +VA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ N L + N G +S + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFL-NQDLKKFMDGSNISG-----ISLALVKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHR 507 A+ H+H+VLHR Sbjct: 116 AFCHSHRVLHR 126
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 56.6 bits (135), Expect = 4e-08 Identities = 37/135 (27%), Positives = 64/135 (47%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G D + VAVK L K + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNDHTKVAVKSL-KQGSMSPDAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSG-----IKLTINKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHR 507 A +A++ +HR Sbjct: 348 AEGMAFIEERNYIHR 362
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 7/121 (5%) Frame = +1 Query: 145 ELGAGGFGTVYK---GVLRD--GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 +LG G FG+V L+D G VVAVK+L ++ + + F E++IL L+H N+V Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 310 YGCTSSC--RDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 G S R+L L+ E++P G+L D+L +L + +++ +E Y+ Sbjct: 914 KGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYI 973 Query: 484 H 486 H Sbjct: 974 H 974 Score = 47.4 bits (111), Expect = 2e-05 Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD--------GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLV 303 LG G F ++KGV R+ + V +K L K E F ++S+L H +LV Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 YG + +LV EFV G+L +L + + + W +LG+A + A A+ +L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNK----NSINILW--KLGVAKQLAWAMHFL 664 Query: 484 HAHQVLH 504 ++H Sbjct: 665 EEKSLIH 671
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/126 (30%), Positives = 59/126 (46%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 F +LG G FG V++G+ VA+K + K++ + A E+ L LRH L+ L Sbjct: 230 FALGRKLGEGYFGEVWEGLWLGSLPVAIK-VIKSANMKLTDLAKEIQTLKGLRHERLIRL 288 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 + S + +V E + G L L G + L P LG A + A ++YL Sbjct: 289 HAVCSGGEPVYIVTELMRKGNLQAFL-----GTPEGRALRLPPLLGFACQVAEGMSYLEE 343 Query: 490 HQVLHR 507 +V+HR Sbjct: 344 QRVVHR 349
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/129 (28%), Positives = 66/129 (51%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLY-------KNSYKG-VEQFANEVDILSRLRHPNL 300 +G G FG VY G+ L G ++A+K++ K +G + + EV +L L HPN+ Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNI 133 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V G L ++ EFVP G+++ L + +P+++ + +L + +E Y Sbjct: 134 VRYLGTVRESDSLNILMEFVPGGSISSLLEKFGS-FPEPVIIMYTKQLLLGLE------Y 186 Query: 481 LHAHQVLHR 507 LH + ++HR Sbjct: 187 LHNNGIMHR 195
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 56.2 bits (134), Expect = 5e-08 Identities = 35/121 (28%), Positives = 57/121 (47%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 352 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 411 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + ++ W R+ A + AA +AYLH+ ++H Sbjct: 412 KEKRLNFITEYIKGGTLRGLIKSMDS------HYPWSQRVSFAKDIAAGMAYLHSMNIIH 465 Query: 505 R 507 R Sbjct: 466 R 466
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 56.2 bits (134), Expect = 5e-08 Identities = 36/140 (25%), Positives = 63/140 (45%) Frame = +1 Query: 88 HIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEV 267 +++ +E + +LG+G FG V+ G ++ VA+K L K E F E Sbjct: 220 NLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTL-KEGTMSPEAFLGEA 278 Query: 268 DILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLG 447 +++ L+H LV LY + + +V E++ G L D L LS P + Sbjct: 279 NVMKTLQHERLVRLYAVVTR-EPIYIVTEYMARGCLLDFLKTDEGS-----RLSLPRLID 332 Query: 448 IAVETAAALAYLHAHQVLHR 507 ++ + A +AY+ +HR Sbjct: 333 MSAQVAEGMAYIERMNSIHR 352
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L + DP W ++ A A+ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLRN-----VDP--FPWQQKVRFAKGIASGMAYLHSMCIIH 449 Query: 505 R 507 R Sbjct: 450 R 450
>ATG1_COLLN (P87248) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Colletotrichum lindemuthianum kinase 1) Length = 675 Score = 56.2 bits (134), Expect = 5e-08 Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 17/149 (11%) Frame = +1 Query: 112 DAATDGFGAANELGAGGFGTVYKGVLRDG-SVVAVK--RLYKNSYKGVEQFANEVDILSR 282 DA+ F E+G G F VY G ++ + VA+K + + + K E E+ IL Sbjct: 19 DASIGEFVIGGEIGKGSFAQVYSGHHKNSKAAVAIKSVEMGRLNNKLRENLYGEIQILKT 78 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAGGGDPLMLSWPTRLGI 450 LRHP++VAL+ C S + LV E+ G L+ + HG + + +P G Sbjct: 79 LRHPHIVALHDCVESATHINLVMEYCELGDLSFFIKKRDRHGTNAATEDMARKYPVTPGS 138 Query: 451 AV----------ETAAALAYLHAHQVLHR 507 + + A+AL +L +HR Sbjct: 139 GLHEVVTRHFLQQLASALKFLREKNYVHR 167
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 56.2 bits (134), Expect = 5e-08 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + ++ W R+ A + A+ +AYLH+ ++H Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKSMDS------QYPWSQRVSFAKDIASGMAYLHSMNIIH 458 Query: 505 R 507 R Sbjct: 459 R 459
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 56.2 bits (134), Expect = 5e-08 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + ++ W R+ A + A+ +AYLH+ ++H Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKSMDS------QYPWSQRVSFAKDIASGMAYLHSMNIIH 458 Query: 505 R 507 R Sbjct: 459 R 459
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 56.2 bits (134), Expect = 5e-08 Identities = 39/126 (30%), Positives = 62/126 (49%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY------KGVEQFANEVDILSRLRHPNLVAL 309 LG G +GTVY G+ G ++AVK++ ++ K + EVD+L L+H N+VA Sbjct: 1067 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAY 1126 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G + + EFVP G+++ + N G P M+ + +AYLH Sbjct: 1127 LGTCLQENTVSIFMEFVPGGSISSII---NRFGPLPEMVF----CKYTKQILQGVAYLHE 1179 Query: 490 HQVLHR 507 + V+HR Sbjct: 1180 NCVVHR 1185
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 55.8 bits (133), Expect = 6e-08 Identities = 43/126 (34%), Positives = 60/126 (47%), Gaps = 6/126 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKG----VEQFANEVDILSRLRHPNLVALY 312 LGAG FG V + + G VAVK L K + KG +E +E+DIL RL HPN+VA Sbjct: 43 LGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFK 102 Query: 313 GCTSSCRDLLLVYEFVPNGTLADH-LHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 S ++ + G L D L G D + I VE +A+ Y+H+ Sbjct: 103 DWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVR--------ILVEILSAVKYMHS 154 Query: 490 HQVLHR 507 ++HR Sbjct: 155 QNIVHR 160
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 55.8 bits (133), Expect = 6e-08 Identities = 36/120 (30%), Positives = 58/120 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G S+ Sbjct: 73 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YST 131 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 132 KPQLAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 185
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 55.8 bits (133), Expect = 6e-08 Identities = 42/138 (30%), Positives = 66/138 (47%), Gaps = 17/138 (12%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLR-----DGSVVAVKRL--YKNSYKGVEQFANEVDILSRLRHPNLV 303 ELG FG +YKG L +VA+K L Y N + E F E +++ L HPN+V Sbjct: 478 ELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTE-FQQEASLMAELHHPNIV 536 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAG------GGDPLMLSWPTRLGIA 453 L G + + + +++E++ G L + L H + G G L L IA Sbjct: 537 CLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIA 596 Query: 454 VETAAALAYLHAHQVLHR 507 ++ AA + YL +H +H+ Sbjct: 597 IQIAAGMEYLSSHFFVHK 614
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 55.8 bits (133), Expect = 6e-08 Identities = 36/120 (30%), Positives = 58/120 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G S+ Sbjct: 25 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YST 83 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 84 KPQLAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 137
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 55.8 bits (133), Expect = 6e-08 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L DP W ++ A A+ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLR-----SMDP--FPWQQKVRFAKGIASGMAYLHSMCIIH 449 Query: 505 R 507 R Sbjct: 450 R 450
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 55.8 bits (133), Expect = 6e-08 Identities = 36/120 (30%), Positives = 58/120 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G S+ Sbjct: 503 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YST 561 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 562 KPQLAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 615
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 55.8 bits (133), Expect = 6e-08 Identities = 36/120 (30%), Positives = 58/120 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G S+ Sbjct: 463 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YST 521 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 522 KPQLAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 575
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 55.8 bits (133), Expect = 6e-08 Identities = 36/120 (30%), Positives = 58/120 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G S+ Sbjct: 503 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YST 561 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 562 KPQLAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 615
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 55.8 bits (133), Expect = 6e-08 Identities = 36/120 (30%), Positives = 58/120 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G S+ Sbjct: 89 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YST 147 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 148 KPQLAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 201
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 55.8 bits (133), Expect = 6e-08 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 7/121 (5%) Frame = +1 Query: 145 ELGAGGFGTVYK---GVLRD--GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 +LG G FG+V L+D G VVAVK+L ++ + + F E++IL L+H N+V Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 310 YGCTSSC--RDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 G S R+L L+ E++P G+L D+L +L + +++ +E Y+ Sbjct: 914 KGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYI 973 Query: 484 H 486 H Sbjct: 974 H 974 Score = 43.5 bits (101), Expect = 3e-04 Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD--------GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLV 303 LG G F ++KGV R+ + V +K L K E F ++S+L H +LV Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 610 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 YG + +LV EFV G+L +L + + + W +L +A + A A+ +L Sbjct: 611 LNYGVCVCGDENILVQEFVKFGSLDTYLKKNK----NCINILW--KLEVAKQLAWAMHFL 664 Query: 484 HAHQVLH 504 + ++H Sbjct: 665 EENTLIH 671
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 55.8 bits (133), Expect = 6e-08 Identities = 46/134 (34%), Positives = 70/134 (52%), Gaps = 8/134 (5%) Frame = +1 Query: 130 FGAAN------ELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFA-NEVDILSRL 285 FGAA+ +LG G + TVYKG+ R +G +VA+K + N+ +GV A E +L L Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105 Query: 286 RHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETA 465 +H N+V L+ + L V+E++ + LA ++ + GG P RL + Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYM-HTDLAQYMSQ-HPGGLHP----HNVRL-FMFQLL 158 Query: 466 AALAYLHAHQVLHR 507 LAY+H VLHR Sbjct: 159 RGLAYIHHQHVLHR 172
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 55.5 bits (132), Expect = 8e-08 Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 2/128 (1%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFA-NEVDILSRLRHPNLV 303 F +LG G + TVYKG R G +VA+K + +S +G A E+ ++ L+H N+V Sbjct: 7 FQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIREISLMKELKHENIV 66 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 LY + L LV+E++ +GN G + + W + + + Sbjct: 67 TLYDVIHTENKLNLVFEYMDKDLKKFMDTNGNKGALETKQVKW-----FMYQLLRGILFC 121 Query: 484 HAHQVLHR 507 H ++VLHR Sbjct: 122 HDNRVLHR 129
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 55.5 bits (132), Expect = 8e-08 Identities = 39/127 (30%), Positives = 61/127 (48%), Gaps = 5/127 (3%) Frame = +1 Query: 142 NELGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKGVEQF----ANEVDILSRLRHPNLVA 306 N +G G FG VY V L +G ++AVK + K +++ E+ +L L HPN+V+ Sbjct: 1270 NFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVS 1329 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 YG + + E+ G+LA L HG D ++ T ++ LAYLH Sbjct: 1330 YYGVEVHRDKVNIFMEYCEGGSLAALLEHGRI--EDEMVTQVYT-----LQLLEGLAYLH 1382 Query: 487 AHQVLHR 507 ++HR Sbjct: 1383 ESGIVHR 1389
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 55.5 bits (132), Expect = 8e-08 Identities = 46/151 (30%), Positives = 72/151 (47%), Gaps = 5/151 (3%) Frame = +1 Query: 58 EFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSY 237 E N G+ +++ + T F +G G VY+ +R+ AVK L+K Sbjct: 154 EHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRN-QAYAVK-LFKQEK 211 Query: 238 KGV-----EQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNA 402 K ++F +E+++L RHP+++ L + L LVY ++ NGTL D L N Sbjct: 212 KMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTN- 270 Query: 403 GGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 G P LSW R+ + + A A+ YLH Q Sbjct: 271 -GTTP--LSWHVRISVLIGIAKAIQYLHNTQ 298
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 55.5 bits (132), Expect = 8e-08 Identities = 37/138 (26%), Positives = 71/138 (51%), Gaps = 2/138 (1%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 +++++ + NE+G G FG+V++ VA K L ++S E+F E I+ Sbjct: 210 FQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKML-QSSKAEREKFVLEAKIMH 268 Query: 280 RLRHPNLVALYGCTSSCRD--LLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 +LRH +V L G + +D +L++ E++ NG+L ++L D + + + Sbjct: 269 KLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLK-----TPDGKKTNLNQMVHMM 323 Query: 454 VETAAALAYLHAHQVLHR 507 E + +AYL + +V+HR Sbjct: 324 AEISEGMAYLESEKVVHR 341
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 1/122 (0%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 +LG G +G VYKG+ + + A+K K+ K + +F E++I+ +L HPN+V LY Sbjct: 76 KLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETY 135 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 + + L+ E L D + + + I + +A+ YLH+ ++ Sbjct: 136 ENDNYIYLIMELCSGRELFDSIIENGS-------FTEKNAATIMKQIFSAIFYLHSLNIV 188 Query: 502 HR 507 HR Sbjct: 189 HR 190
>ERBB2_MESAU (Q60553) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1254 Score = 55.1 bits (131), Expect = 1e-07 Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ L P + L Sbjct: 726 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGLGSPYVSRL 785 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 786 LGICLTS--TVQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 835 Query: 481 LHAHQVLHR 507 L +++HR Sbjct: 836 LEDVRLVHR 844
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/124 (30%), Positives = 61/124 (49%), Gaps = 4/124 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKG---VEQFANEVDILSRLRHPNLVALYG 315 +G G FG V +G ++ G VA+K L + KG V + NE+D L +L HP++ L+ Sbjct: 30 IGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFR 89 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 S+ D+ LV E V G L ++ G P+ S + + ++Y H H Sbjct: 90 VISTPSDIFLVMELVSGGELFSYI---TRKGALPIRES----RRYFQQIISGVSYCHNHM 142 Query: 496 VLHR 507 ++HR Sbjct: 143 IVHR 146
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 1/122 (0%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 +LG G +G VYKG+ + + A+K K+ K + +F E++I+ +L HPN+V LY Sbjct: 76 KLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETY 135 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 + + L+ E L D + + + I + +A+ YLH+ ++ Sbjct: 136 ENDNYIYLIMELCSGRELFDSIIENGS-------FTEKNAATIMKQIFSAIFYLHSLNIV 188 Query: 502 HR 507 HR Sbjct: 189 HR 190
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 54.7 bits (130), Expect = 1e-07 Identities = 36/121 (29%), Positives = 55/121 (45%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG G FG V G R VA+K + + S ++F E ++ L H LV LYG + Sbjct: 406 ELGTGQFGVVKYGKWRGQYDVAIKMIREGS-MSEDEFIEEAKVMMNLSHEKLVQLYGVCT 464 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 R + ++ E++ NG L ++L L + + A+ YL + Q LH Sbjct: 465 KQRPIFIITEYMANGCLLNYLREMRH------RFQTQQLLEMCKDVCEAMEYLESKQFLH 518 Query: 505 R 507 R Sbjct: 519 R 519
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 54.7 bits (130), Expect = 1e-07 Identities = 36/121 (29%), Positives = 54/121 (44%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG G FG V G R VA+K + K ++F E ++ L H LV LYG + Sbjct: 406 ELGTGQFGVVKYGKWRGQYDVAIK-MIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCT 464 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 R + ++ E++ NG L ++L L + + A+ YL + Q LH Sbjct: 465 KQRPIFIITEYMANGCLLNYLREMRH------RFQTQQLLEMCKDVCEAMEYLESKQFLH 518 Query: 505 R 507 R Sbjct: 519 R 519
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 54.7 bits (130), Expect = 1e-07 Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 2/123 (1%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFAN-EVDILSRLRHPNLVALYGC 318 ++G G +GTV K +D G +VA+K Y+ K V + A E+ L + RH NLV L Sbjct: 9 KVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEV 68 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + + LV+EF+ + T+ D L H G + + ++ A+E YLH + + Sbjct: 69 FRQKKKIHLVFEFIDH-TVLDELQHYCHGLESKRLRKYLFQILRAIE------YLHNNNI 121 Query: 499 LHR 507 +HR Sbjct: 122 IHR 124
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 54.7 bits (130), Expect = 1e-07 Identities = 36/121 (29%), Positives = 58/121 (47%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L DP W ++ A ++ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLR-----SVDP--FPWQQKVRFAKGISSGMAYLHSMCIIH 449 Query: 505 R 507 R Sbjct: 450 R 450
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 54.7 bits (130), Expect = 1e-07 Identities = 34/120 (28%), Positives = 54/120 (45%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVY+ V + S ++ F NEV +L + RH N++ GC S Sbjct: 435 IGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSK 494 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L H+H T + I + A + YLHA ++HR Sbjct: 495 -PSLAIVTQWCEGSSLYKHVHVSET------KFKLNTLIDIGRQVAQGMDYLHAKNIIHR 547
>SLK_HUMAN (Q9H2G2) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9) Length = 1235 Score = 54.7 bits (130), Expect = 1e-07 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 8/162 (4%) Frame = +1 Query: 46 SLRKEFNLAGSPCTHIFTYEELDAATDGFGAA-NELGAGGFGTVYKGVLRDGSVVAVKRL 222 + RK F L + + + D + F ELG G FG VYK ++ SV+A ++ Sbjct: 5 NFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKV 64 Query: 223 YKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 S + +E + E+DIL+ HPN+V L +L ++ EF G + Sbjct: 65 IDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAV-------- 116 Query: 400 AGGGDPLMLSWPTRLG------IAVETAAALAYLHAHQVLHR 507 D +ML L + +T AL YLH ++++HR Sbjct: 117 ----DAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHR 154
>CDKL3_RAT (Q9JM01) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIATRE) Length = 593 Score = 54.7 bits (130), Expect = 1e-07 Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 2/123 (1%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFAN-EVDILSRLRHPNLVALYGC 318 ++G G +GTV K +D G +VA+K Y+ K V + A E+ L + RH NLV L Sbjct: 9 KVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEV 68 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + + LV+EF+ + T+ D L H G + + ++ A+E YLH + + Sbjct: 69 FRQKKKIHLVFEFIDH-TVLDELQHYCHGLESKRLRKYLFQILRAIE------YLHNNNI 121 Query: 499 LHR 507 +HR Sbjct: 122 IHR 124
>INSR_HUMAN (P06213) Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220| antigen) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1382 Score = 54.7 bits (130), Expect = 1e-07 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 13/156 (8%) Frame = +1 Query: 79 PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD------GSVVAVKRLYKN-SY 237 PC+ ++ +E + + + ELG G FG VY+G RD + VAVK + ++ S Sbjct: 1007 PCS-VYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASL 1065 Query: 238 KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLH------HGN 399 + +F NE ++ ++V L G S + L+V E + +G L +L N Sbjct: 1066 RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENN 1125 Query: 400 AGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G P + + +A E A +AYL+A + +HR Sbjct: 1126 PGRPPPTL---QEMIQMAAEIADGMAYLNAKKFVHR 1158
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 54.7 bits (130), Expect = 1e-07 Identities = 47/161 (29%), Positives = 68/161 (42%), Gaps = 4/161 (2%) Frame = +1 Query: 37 PLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGS-VVAV 213 P TS RK F + + F LG G FG VY L++ +VA+ Sbjct: 3 PSTSTRKHFTI------------------NDFEIGRPLGRGKFGRVYLARLKENHFIVAL 44 Query: 214 KRLYKNSYK--GVE-QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADH 384 K L+K+ + G+E Q EV+I + L+H N++ LY + L+ E+ P G L Sbjct: 45 KVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKE 104 Query: 385 LHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L L I E + AL Y H +V+HR Sbjct: 105 LQRHQ-------KLDQQRTATIIQELSDALTYCHEKKVIHR 138
>M3K4_HUMAN (Q9Y6R4) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/156 (25%), Positives = 74/156 (47%), Gaps = 8/156 (5%) Frame = +1 Query: 64 NLAGSPCTHIFTYEE-----LDAATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVK--R 219 N+ G C +Y+ L T + N++G G +G VY + D G ++A+K R Sbjct: 1315 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIR 1374 Query: 220 LYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 N +K +++ A+E+ I ++HPNLV +G ++ + E+ GTL + Sbjct: 1375 FQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE---VSR 1431 Query: 400 AGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G + ++ + ++ IA+ LH H ++HR Sbjct: 1432 LGLQEHVIRLYSKQITIAINV------LHEHGIVHR 1461
>M3K4_MOUSE (O08648) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 54.3 bits (129), Expect = 2e-07 Identities = 39/156 (25%), Positives = 74/156 (47%), Gaps = 8/156 (5%) Frame = +1 Query: 64 NLAGSPCTHIFTYEE-----LDAATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVK--R 219 N+ G C +Y+ L T + N++G G +G VY + D G ++A+K R Sbjct: 1305 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIR 1364 Query: 220 LYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 N +K +++ A+E+ I ++HPNLV +G ++ + E+ GTL + Sbjct: 1365 FQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE---VSR 1421 Query: 400 AGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G + ++ + ++ +A+ LH H ++HR Sbjct: 1422 LGLQEHVIRLYTKQITVAINV------LHEHGIVHR 1451
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 54.3 bits (129), Expect = 2e-07 Identities = 36/135 (26%), Positives = 60/135 (44%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + +LG+G FG V+ G ++ VA+K L K E F E +++ Sbjct: 231 DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTL-KEGTMSPEAFLGEANMMKA 289 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + +V E++ G L D L LS P + ++ + Sbjct: 290 LQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGS-----RLSLPRLIDMSAQI 343 Query: 463 AAALAYLHAHQVLHR 507 A +AY+ +HR Sbjct: 344 AEGMAYIERMNSIHR 358
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 54.3 bits (129), Expect = 2e-07 Identities = 38/121 (31%), Positives = 57/121 (47%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG G FG V G R VA+K + + S ++F +E ++ L H LV LYG + Sbjct: 405 ELGTGQFGVVKYGKWRGQYNVAIKMIREGS-MSEDEFIDEAKVMMNLSHEKLVQLYGVCT 463 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 R + ++ E++ NG L + L P L L + + A+ YL + Q LH Sbjct: 464 KQRPIFIITEYMANGCLLNFLRE-TQRRFQPAEL-----LEMCKDVCEAMEYLESKQFLH 517 Query: 505 R 507 R Sbjct: 518 R 518
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 54.3 bits (129), Expect = 2e-07 Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 3/169 (1%) Frame = +1 Query: 10 LDGLIREGSPLTSLRK-EFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGV 186 +D L+R PLT N A + +E+L ++G G FG V+ G Sbjct: 182 VDHLLRSQQPLTKKSGIVLNRAVPKDKWVLNHEDLVLG-------EQIGRGNFGEVFSGR 234 Query: 187 LR-DGSVVAVKRLYKNSYKGVE-QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFV 360 LR D ++VAVK + ++ +F E IL + HPN+V L G + + + +V E V Sbjct: 235 LRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVCTQKQPIYIVMELV 294 Query: 361 PNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G L A L T L + + AA + YL + +HR Sbjct: 295 QGGDFLTFLRTEGA------RLRMKTLLQMVGDAAAGMEYLESKCCIHR 337
>ERBB2_MOUSE (P70424) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1256 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/129 (34%), Positives = 70/129 (54%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 727 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 786 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 787 LGICLTS--TVQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 836 Query: 481 LHAHQVLHR 507 L +++HR Sbjct: 837 LEEVRLVHR 845
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 54.3 bits (129), Expect = 2e-07 Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 3/169 (1%) Frame = +1 Query: 10 LDGLIREGSPLTSLRK-EFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGV 186 +D L+R PLT N A + +E+L ++G G FG V+ G Sbjct: 314 VDHLLRSQQPLTKKSGIVLNRAVPKDKWVLNHEDLVLG-------EQIGRGNFGEVFSGR 366 Query: 187 LR-DGSVVAVKRLYKNSYKGVE-QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFV 360 LR D ++VAVK + ++ +F E IL + HPN+V L G + + + +V E V Sbjct: 367 LRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVCTQKQPIYIVMELV 426 Query: 361 PNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G L A L T L + + AA + YL + +HR Sbjct: 427 QGGDFLTFLRTEGA------RLRMKTLLQMVGDAAAGMEYLESKCCIHR 469
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KGV + +G + + K G + F D + L H ++V L Sbjct: 715 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRL 774 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 775 LGLCPGS--SLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNW------GVQIAKGMYYLE 826 Query: 487 AHQVLHR 507 H ++HR Sbjct: 827 EHGMVHR 833
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KGV + +G + + K G + F D + L H ++V L Sbjct: 715 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRL 774 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 775 LGLCPGS--SLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNW------GVQIAKGMYYLE 826 Query: 487 AHQVLHR 507 H ++HR Sbjct: 827 EHGMVHR 833
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +G G +G VYK + + VVA+K + + + + E+ +L L H N+V +G Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIR 90 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 +L ++ E+ NG+L + + G LS +T L YLH V+H Sbjct: 91 KSYELYILLEYCANGSLRRLISRSSTG------LSENESKTYVTQTLLGLKYLHGEGVIH 144 Query: 505 R 507 R Sbjct: 145 R 145
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 54.3 bits (129), Expect = 2e-07 Identities = 36/135 (26%), Positives = 63/135 (46%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G + + VAVK L K + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSL-KQGSMSPDAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHKRLVRLYAVVTE-EPIYIITEYMENGSLVDFLKTPSG-----IKLTINKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHR 507 +A+L +HR Sbjct: 348 VEGMAFLEERNYIHR 362
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 54.3 bits (129), Expect = 2e-07 Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 3/169 (1%) Frame = +1 Query: 10 LDGLIREGSPLTSLRK-EFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGV 186 +D L+R PLT N A + +E+L ++G G FG V+ G Sbjct: 525 VDHLLRSQQPLTKKSGIVLNRAVPKDKWVLNHEDLVLG-------EQIGRGNFGEVFSGR 577 Query: 187 LR-DGSVVAVKRLYKNSYKGVE-QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFV 360 LR D ++VAVK + ++ +F E IL + HPN+V L G + + + +V E V Sbjct: 578 LRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVCTQKQPIYIVMELV 637 Query: 361 PNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G L A L T L + + AA + YL + +HR Sbjct: 638 QGGDFLTFLRTEGA------RLRMKTLLQMVGDAAAGMEYLESKCCIHR 680
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 53.9 bits (128), Expect = 2e-07 Identities = 43/139 (30%), Positives = 66/139 (47%), Gaps = 8/139 (5%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFA-NEVDILSRLR 288 +++ F +LG G + TVYKG+ + G VA+K + +S +G A E+ ++ L+ Sbjct: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 Query: 289 HPNLVALYGCTSSCRDLLLVYEFVPNG--TLADHLHHGNAGGGDPLML----SWPTRLGI 450 H N+V LY + L LV+EF+ N D GN G L L W G Sbjct: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG- 120 Query: 451 AVETAAALAYLHAHQVLHR 507 LA+ H +++LHR Sbjct: 121 -------LAFCHENKILHR 132
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 53.9 bits (128), Expect = 2e-07 Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 5/158 (3%) Frame = +1 Query: 49 LRKEFNLAGSPCTHIFTYEELDAATDGFGAANEL---GAGGFGTVYKGVLRDGSVVAVKR 219 LR +N+ G + + ++ D F +EL G+G G V+ G R VA+K+ Sbjct: 138 LRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFR-AEEVAIKK 196 Query: 220 LYKNSYKGVEQFANEVDI--LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 + + NE DI L +L+HPN++A G + ++ E+ +G L + L Sbjct: 197 VREQ---------NETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA 247 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G L++ W T + A+ + YLH H+++HR Sbjct: 248 GRK-ITPRLLVDWSTGI------ASGMNYLHLHKIIHR 278
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 2/137 (1%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSV-VAVKRLYKN-SYKGVEQFANEVDIL 276 E + + D +G G FG VYK L+ + VAVK + +F E IL Sbjct: 1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 + HPN+V L G + +++V E V G+L +L + G L+ ++G+ Sbjct: 1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG------LTTRQQMGMCR 1167 Query: 457 ETAAALAYLHAHQVLHR 507 + AA + YL + +HR Sbjct: 1168 DAAAGMRYLESKNCIHR 1184
>ERBB2_RAT (P06494) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) Length = 1257 Score = 53.9 bits (128), Expect = 2e-07 Identities = 44/129 (34%), Positives = 70/129 (54%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 728 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 787 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 788 LGICLTS--TVQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 837 Query: 481 LHAHQVLHR 507 L +++HR Sbjct: 838 LEDVRLVHR 846
>ERBB2_CANFA (O18735) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) Length = 1259 Score = 53.9 bits (128), Expect = 2e-07 Identities = 44/129 (34%), Positives = 70/129 (54%), Gaps = 9/129 (6%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 725 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 784 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 785 LGICLTS--TVQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 834 Query: 481 LHAHQVLHR 507 L +++HR Sbjct: 835 LEDVRLVHR 843
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 53.9 bits (128), Expect = 2e-07 Identities = 38/123 (30%), Positives = 62/123 (50%), Gaps = 3/123 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYK--NSYKGVEQFANEVDILSRLRHPNLVALYGC 318 +G G FG VYKG + VVA+K + K S K + E++I+ L HPN+V + Sbjct: 10 IGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDS 69 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +++++V ++ G L L D + IA + +AL YLH+H++ Sbjct: 70 FETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQ-------AIAAQLVSALYYLHSHRI 121 Query: 499 LHR 507 LHR Sbjct: 122 LHR 124
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/120 (35%), Positives = 56/120 (46%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VAVK L K + F E I+ LRH LV LY S Sbjct: 257 LGTGCFGDVWLGTWNCSTKVAVKTL-KPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSE 315 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V EF+ G+L D L G LML P + +A + A +AY+ +HR Sbjct: 316 -EPIYIVTEFMCYGSLLDFLKDRE---GQNLML--PHLVDMAAQVAEGMAYMERMNYIHR 369
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/125 (31%), Positives = 59/125 (47%), Gaps = 4/125 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHPNLVALYGC 318 ++G G +G VYK DG A+K++ + +G+ A E+ IL LRH N+V LY Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDV 68 Query: 319 TSSCRDLLLVYEFVPNG--TLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 + + L+LV+E + L D G L T ++ +AY H H Sbjct: 69 IHAKKRLILVFEHLDQDLKKLIDVCDGG---------LESVTAKSFLLQLLNGIAYCHEH 119 Query: 493 QVLHR 507 +VLHR Sbjct: 120 RVLHR 124
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/125 (31%), Positives = 59/125 (47%), Gaps = 4/125 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHPNLVALYGC 318 ++G G +G VYK DG A+K++ + +G+ A E+ IL LRH N+V LY Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDV 68 Query: 319 TSSCRDLLLVYEFVPNG--TLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 + + L+LV+E + L D G L T ++ +AY H H Sbjct: 69 IHAKKRLILVFEHLDQDLKKLIDVCDGG---------LESVTAKSFLLQLLNGIAYCHEH 119 Query: 493 QVLHR 507 +VLHR Sbjct: 120 RVLHR 124
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 53.9 bits (128), Expect = 2e-07 Identities = 46/182 (25%), Positives = 80/182 (43%), Gaps = 21/182 (11%) Frame = +1 Query: 25 REGSPLTSLR----KEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVL- 189 +EG PLT L+ +NL H+ T +G G FG V+ G Sbjct: 467 QEGVPLTGLQLVDNPNYNLTKKK--HVATTCPKTVRLQTILLMRVIGEGAFGRVFLGTCA 524 Query: 190 -----RDGSVVAVKRLYKNSYKGVEQ-FANEVDILSRLRHPNLVALYGCTSSCRDLLLVY 351 + ++VAVK L + +++ F E ++L+ + H N+V YG + ++++ Sbjct: 525 HLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIVTFYGVCTESDQWMMIF 584 Query: 352 EFVPNGTLADHLH-HG---------NAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 EF+ NG L +L HG ++ D L+ + I ++ A+A+ YL + Sbjct: 585 EFMENGDLNKYLRMHGPDAAFLKDRDSMDSDEGQLTREQLMKIVLQIASAMEYLALQHFV 644 Query: 502 HR 507 HR Sbjct: 645 HR 646
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/135 (26%), Positives = 63/135 (46%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G + VAVK L K + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSL-KQGSMSPDAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSG-----IKLTINKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHR 507 A +A++ +HR Sbjct: 348 AEGMAFIEERNYIHR 362
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 53.9 bits (128), Expect = 2e-07 Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 8/162 (4%) Frame = +1 Query: 46 SLRKEFNLAGSPCTHIFTYEELDAATDGFGAA-NELGAGGFGTVYKGVLRDGSVVAVKRL 222 + RK F L + + + D + F ELG G FG VYK ++ +V+A ++ Sbjct: 5 NFRKIFKLGSEKKKKQYEHVKRDLNPEEFWETIGELGDGAFGKVYKAQNKETNVLAAAKV 64 Query: 223 YKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 S + +E + E+DIL+ HPN+V L +L ++ EF G + Sbjct: 65 IDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAV-------- 116 Query: 400 AGGGDPLMLSWPTRLG------IAVETAAALAYLHAHQVLHR 507 D +ML L + +T AL YLH ++++HR Sbjct: 117 ----DAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHR 154
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 53.5 bits (127), Expect = 3e-07 Identities = 35/126 (27%), Positives = 55/126 (43%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 F ++G GGFG VY +G VA+K++ + + E+ + LRH N+V Sbjct: 13 FQNLQQIGQGGFGVVYSAQRENGEKVAIKKI--GNAASQTRIKEEIKTMKLLRHRNIVQF 70 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 Y + LV E G+L D++ L T + I + AA+ Y+H Sbjct: 71 YETFFENGETYLVMELCEGGSLMDYVKQKGP-------LDDSTAVHILRQLIAAVKYIHD 123 Query: 490 HQVLHR 507 +LHR Sbjct: 124 ENILHR 129
>SLK_RAT (O08815) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1206 Score = 53.5 bits (127), Expect = 3e-07 Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 8/162 (4%) Frame = +1 Query: 46 SLRKEFNLAGSPCTHIFTYEELDAATDGFGAA-NELGAGGFGTVYKGVLRDGSVVAVKRL 222 + RK F L + + + D + F ELG G FG VYK ++ +V+A ++ Sbjct: 5 NFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKV 64 Query: 223 YKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 S + +E + E+DIL+ HPN+V L +L ++ EF G + Sbjct: 65 IDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAV-------- 116 Query: 400 AGGGDPLMLSWPTRLG------IAVETAAALAYLHAHQVLHR 507 D +ML L + +T AL YLH ++++HR Sbjct: 117 ----DAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHR 154
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 53.5 bits (127), Expect = 3e-07 Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 8/162 (4%) Frame = +1 Query: 46 SLRKEFNLAGSPCTHIFTYEELDAATDGFGAA-NELGAGGFGTVYKGVLRDGSVVAVKRL 222 + RK F L + + + D + F ELG G FG VYK ++ +V+A ++ Sbjct: 5 NFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKV 64 Query: 223 YKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 S + +E + E+DIL+ HPN+V L +L ++ EF G + Sbjct: 65 IDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAV-------- 116 Query: 400 AGGGDPLMLSWPTRLG------IAVETAAALAYLHAHQVLHR 507 D +ML L + +T AL YLH ++++HR Sbjct: 117 ----DAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHR 154
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 53.5 bits (127), Expect = 3e-07 Identities = 43/158 (27%), Positives = 73/158 (46%), Gaps = 5/158 (3%) Frame = +1 Query: 49 LRKEFNLAGSPCTHIFTYEELDAATDGFGAANEL---GAGGFGTVYKGVLRDGSVVAVKR 219 LR +N+ G + ++ D F +EL G+G G V+ G R VA+K+ Sbjct: 138 LRPVWNIIGKAYATDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFR-AEEVAIKK 196 Query: 220 LYKNSYKGVEQFANEVDI--LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 + + NE DI L +L+HPN++A G + ++ E+ +G L + L Sbjct: 197 VREQ---------NETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA 247 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G L++ W T + A+ + YLH H+++HR Sbjct: 248 GRK-ITPRLLVDWSTGI------ASGMNYLHLHKIIHR 278
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 53.5 bits (127), Expect = 3e-07 Identities = 44/156 (28%), Positives = 68/156 (43%), Gaps = 16/156 (10%) Frame = +1 Query: 88 HIFTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK 240 H TYE+ + A F E +GAG FG V G LR S ++ K+ Sbjct: 603 HPHTYEDPNQAVRDFAKEIEVSNIRIERVIGAGEFGEVCSGRLRLPSKREIQVAIKSLKA 662 Query: 241 GVEQ-----FANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL--HHGN 399 G + F +E I+ + HPN++ L G + C+ +++V E++ NG+L L H G Sbjct: 663 GYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDG- 721 Query: 400 AGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + LG+ AA + YL +HR Sbjct: 722 -------QFTVIQLLGMLRGIAAGMQYLSEMNYVHR 750
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 53.5 bits (127), Expect = 3e-07 Identities = 41/124 (33%), Positives = 56/124 (45%), Gaps = 4/124 (3%) Frame = +1 Query: 148 LGAGGFGTVYK-GVLRDGSVVAVKRL---YKNSYKGVEQFANEVDILSRLRHPNLVALYG 315 LG G FG VY +DG A+K L Y K VE +E ILS + HP +V LY Sbjct: 342 LGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPFIVNLYQ 401 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L L++E+V G + HL + S T A E AL +LH Sbjct: 402 AFQDEKKLYLLFEYVAGGEVFTHLRKS-------MKFSNSTAKFYAAEIVLALEFLHKQN 454 Query: 496 VLHR 507 +++R Sbjct: 455 IVYR 458
>ATG1_USTMA (Q4P0K0) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 990 Score = 53.5 bits (127), Expect = 3e-07 Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 24/156 (15%) Frame = +1 Query: 112 DAATDGFGAANELGAGGFGTVYKGV-LRDGSVVAVKRLYKNSY--KGVEQFANEVDILSR 282 D F NE+G G F V+KG L+ VA+K + + K ++ E+ IL Sbjct: 9 DERIGDFVIENEIGKGSFAVVHKGYRLQPREPVAIKIVIRKKLTPKLLDNLEGEIAILKA 68 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLH-----HGNAGGGDPLML------S 429 + HPN+V L C + + LV F +G LA ++ + AG +P L + Sbjct: 69 IHHPNIVELKECLKTEHQIYLVMAFCASGDLAQYIKKRFDIYERAGMAEPDSLTKGFKPT 128 Query: 430 WPTRL----------GIAVETAAALAYLHAHQVLHR 507 +P + I + AAAL ++ A ++HR Sbjct: 129 YPHPVDGGLNETIVRSILTQLAAALEFMRARDIVHR 164
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 53.5 bits (127), Expect = 3e-07 Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 1/122 (0%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 ELG G FG VYK ++ G++ A K + S + +E + E++IL+ HP +V L G Sbjct: 41 ELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAY 100 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 L ++ EF P G + + + G L+ P + + AL +LH+ +++ Sbjct: 101 YHDGKLWIMIEFCPGGAVDAIMLELDRG------LTEPQIQVVCRQMLEALNFLHSKRII 154 Query: 502 HR 507 HR Sbjct: 155 HR 156
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 53.5 bits (127), Expect = 3e-07 Identities = 32/136 (23%), Positives = 64/136 (47%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 +++ + + F +LGAG FG V++ + + VAVK + +++ F E+ + Sbjct: 181 WDDWERPREEFTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMK 240 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 +LRH ++++LY ++ + ++ E +P G L L D L + A + Sbjct: 241 KLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLR-----DSDEKALPILELVDFASQ 295 Query: 460 TAAALAYLHAHQVLHR 507 A + YL + +HR Sbjct: 296 VAEGMCYLESQNYIHR 311
>INSRR_MOUSE (Q9WTL4) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 53.5 bits (127), Expect = 3e-07 Identities = 45/174 (25%), Positives = 78/174 (44%), Gaps = 13/174 (7%) Frame = +1 Query: 25 REGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLR---- 192 R + TS+ E+ A +H++ +E + + ELG G FG VY+G+ R Sbjct: 948 RNSTLYTSVNPEYFSA----SHMYVPDEWEVPREQIAIIRELGQGSFGMVYEGLARGLEA 1003 Query: 193 --DGSVVAVKRLYK-NSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVP 363 + + VA+K + + S + +F E ++ + ++V L G S + L++ E + Sbjct: 1004 GEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMT 1063 Query: 364 NGTLADHLH------HGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 G L HL N G P + + +A E A +AYL A + +HR Sbjct: 1064 RGDLKSHLRSLRPEAENNPGLPQPAL---SDMIQMAGEIADGMAYLAAKKFVHR 1114
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 53.5 bits (127), Expect = 3e-07 Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 1/121 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R G V+ +K L + + F EV ++ L HP+++ G Sbjct: 320 LGRGCFGQAIKVTHRVTGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPHVLKFIGVLY 379 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++P GTL + + W R+ A + AA + YLH+ ++H Sbjct: 380 KDKRLNFITEYIPGGTLRRVIKSMDT------HCPWNQRVSFARDIAAGMTYLHSMNIIH 433 Query: 505 R 507 R Sbjct: 434 R 434
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 53.1 bits (126), Expect = 4e-07 Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 8/134 (5%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFA-NEVDILSRLRHPNLV 303 F +LG G + TVYKG+ + G VA+K + +S +G A E+ ++ L+H N+V Sbjct: 6 FKQLEKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIV 65 Query: 304 ALYGCTSSCRDLLLVYEFVPNG--TLADHLHHGNAGGGDPLML----SWPTRLGIAVETA 465 LY + L LV+E++ N D GNA G + L W + Sbjct: 66 RLYDVIHTENKLTLVFEYMDNDLKKYMDSRTVGNAPRGLEMNLVKYFQW--------QLL 117 Query: 466 AALAYLHAHQVLHR 507 LA+ H +++LHR Sbjct: 118 EGLAFCHENKILHR 131
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 14/134 (10%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSV---VAVKRLYKNSYKGVEQ-FANEVDILSRL-RHPNLVALY 312 +G G FG V K ++ + A+KR+ + + K + FA E+++L +L HPN++ L Sbjct: 830 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 889 Query: 313 GCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM---------LSWPTRLGIAVETA 465 G L L E+ P+G L D L DP LS L A + A Sbjct: 890 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 949 Query: 466 AALAYLHAHQVLHR 507 + YL Q +HR Sbjct: 950 RGMDYLSQKQFIHR 963
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 14/134 (10%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSV---VAVKRLYKNSYKGVEQ-FANEVDILSRL-RHPNLVALY 312 +G G FG V K ++ + A+KR+ + + K + FA E+++L +L HPN++ L Sbjct: 828 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 887 Query: 313 GCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM---------LSWPTRLGIAVETA 465 G L L E+ P+G L D L DP LS L A + A Sbjct: 888 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 947 Query: 466 AALAYLHAHQVLHR 507 + YL Q +HR Sbjct: 948 RGMDYLSQKQFIHR 961
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/127 (31%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KG+ + +G + + K G + F D + L H ++V L Sbjct: 713 LGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRL 772 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 773 LGLCPGS--SLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNW------GVQIAKGMYYLE 824 Query: 487 AHQVLHR 507 H ++HR Sbjct: 825 EHSMVHR 831
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 8/138 (5%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFA-NEVDILSRLRH 291 A F ++G G + TVYKG+ + G VA+K + +S +G A E+ ++ L+H Sbjct: 3 APSQFKQLEKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNG--TLADHLHHGNAGGGDPLML----SWPTRLGIA 453 N+V L+ + L LV+EF+ N D+ + GN+ G + L W G+ Sbjct: 63 DNIVRLFDVIHTENKLTLVFEFMDNDLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGV- 121 Query: 454 VETAAALAYLHAHQVLHR 507 A+ H +++LHR Sbjct: 122 -------AFCHENRILHR 132
>STK10_MOUSE (O55098) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 966 Score = 53.1 bits (126), Expect = 4e-07 Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 1/129 (0%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNL 300 D + ELG G FG VYK ++ G++ A K + S + +E + E++IL+ HP + Sbjct: 34 DVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYI 93 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V L G L ++ EF P G + + + G L+ P + + AL + Sbjct: 94 VKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRG------LTEPQIQVVCRQMLEALNF 147 Query: 481 LHAHQVLHR 507 LH +++HR Sbjct: 148 LHGKRIIHR 156
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 53.1 bits (126), Expect = 4e-07 Identities = 47/136 (34%), Positives = 62/136 (45%), Gaps = 8/136 (5%) Frame = +1 Query: 124 DGFGAANE--LGAGGFGTVYKG--VLRDGSVVAVKRLYK-NSYKGVEQFANEVDIL---S 279 DGF + LG G F VY+G V R VA+K + K N K E+ IL S Sbjct: 5 DGFEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELS 64 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 L+H NLV L CT + + LV EF G LAD+L L+ T V+ Sbjct: 65 SLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTT-------LNEDTIQHFVVQ 117 Query: 460 TAAALAYLHAHQVLHR 507 A AL ++ ++HR Sbjct: 118 IAHALEAINKKGIVHR 133
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 53.1 bits (126), Expect = 4e-07 Identities = 42/145 (28%), Positives = 65/145 (44%), Gaps = 7/145 (4%) Frame = +1 Query: 91 IFTYEELDAATDGFGAANELGAGGFGTVYK-----GVLRDGSVVAVKRLYKNSYKGV--E 249 +F E +D D + ELG+G F V K L+ + KR K+S +GV E Sbjct: 3 VFRQENVD---DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRE 59 Query: 250 QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLS 429 EV IL +RHPN++ L+ + D++L+ E V G L D L + L+ Sbjct: 60 DIEREVSILKEIRHPNVITLHEVYENKTDVILILELVAGGELFDFL-------AEKESLT 112 Query: 430 WPTRLGIAVETAAALAYLHAHQVLH 504 + + + YLH+ Q+ H Sbjct: 113 EEEATEFLKQILSGVYYLHSLQIAH 137
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 14/134 (10%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSV---VAVKRLYKNSYKGVEQ-FANEVDILSRL-RHPNLVALY 312 +G G FG V K ++ + A+KR+ + + K + FA E+++L +L HPN++ L Sbjct: 831 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 890 Query: 313 GCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM---------LSWPTRLGIAVETA 465 G L L E+ P+G L D L DP LS L A + A Sbjct: 891 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 950 Query: 466 AALAYLHAHQVLHR 507 + YL Q +HR Sbjct: 951 RGMDYLSQKQFIHR 964
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 53.1 bits (126), Expect = 4e-07 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 3/123 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKR--LYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 LG G FG VY+G+ +++G VAVK+ L K + E+D+L L HPN+V G Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + L ++ E+ NG+L N G +++ T + L YLH V Sbjct: 75 YQTNDSLCIILEYCENGSLRSICK--NFGKIPENLVALYT-----FQVLQGLLYLHNQGV 127 Query: 499 LHR 507 +HR Sbjct: 128 IHR 130
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 53.1 bits (126), Expect = 4e-07 Identities = 41/131 (31%), Positives = 63/131 (48%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASAVTGIPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHR 507 A+ H+H+VLHR Sbjct: 116 AFCHSHRVLHR 126
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 53.1 bits (126), Expect = 4e-07 Identities = 39/131 (29%), Positives = 64/131 (48%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L+ + L LV+EF+ + L + G +S P + L Sbjct: 62 NIVKLHDVIHTENKLYLVFEFL-HQDLKRFMDSSTVTG-----ISLPLVKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHR 507 A+ H+H+VLHR Sbjct: 116 AFCHSHRVLHR 126
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 15/136 (11%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPXQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHR 507 A+ + YL + +HR Sbjct: 663 IASGMVYLASQHFVHR 678
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 53.1 bits (126), Expect = 4e-07 Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHP 294 D + + LG G +G VY+ V R G +VA+K++ + +G+ Q A EV IL + HP Sbjct: 21 DRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHP 80 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L L++E+V + G A G L I + L Sbjct: 81 NIVNLLDVICADGKLYLIFEYVDHDLKKALEKRGGAFTGTTLK-------KIIYQLLEGL 133 Query: 475 AYLHAHQVLHR 507 ++ H H+++HR Sbjct: 134 SFCHRHRIVHR 144
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 53.1 bits (126), Expect = 4e-07 Identities = 40/135 (29%), Positives = 67/135 (49%), Gaps = 14/135 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ ++ ++VAVK L + + F E ++L+ L+H ++V Sbjct: 498 ELGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVK 557 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HG------NAGGGDPL-MLSWPTRLGIAVET 462 YG + L++V+E++ +G L L HG + G G P L+ L IA + Sbjct: 558 FYGVCTEGDPLIMVFEYMKHGDLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQI 617 Query: 463 AAALAYLHAHQVLHR 507 A+ + YL + +HR Sbjct: 618 ASGMVYLASLHFVHR 632
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/131 (31%), Positives = 63/131 (48%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHR 507 A+ H+H+VLHR Sbjct: 116 AFCHSHRVLHR 126
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/131 (30%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHP 294 D + ++G G +G VYKGV + G +VA+K++ +N +GV A E+ +L L+HP Sbjct: 2 DEYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLENEEEGVPSTAIREISLLKELQHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L L L++EF+ + L +L +G ML + + Sbjct: 62 NIVCLLDVLMQDSRLYLIFEFL-SMDLKKYLDSIPSGQYLEAMLV----KSYLYQILQGI 116 Query: 475 AYLHAHQVLHR 507 + HA +VLHR Sbjct: 117 IFCHARRVLHR 127
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 52.8 bits (125), Expect = 5e-07 Identities = 30/120 (25%), Positives = 57/120 (47%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + + +A +TA + YLHA ++HR Sbjct: 376 -PGFAIITQWCEGSSLYHHLHVADT------RFDMVQLIDVARQTAQGMDYLHAKNIIHR 428
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 52.8 bits (125), Expect = 5e-07 Identities = 30/120 (25%), Positives = 57/120 (47%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + + +A +TA + YLHA ++HR Sbjct: 376 -PGFAIITQWCEGSSLYHHLHVADT------RFDMVQLIDVARQTAQGMDYLHAKNIIHR 428
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 13/152 (8%) Frame = +1 Query: 91 IFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD------GSVVAVKRLYKN-SYKGVE 249 ++ +E + + ELG G FG VY+G +D + VAVK + ++ S + Sbjct: 1000 VYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERI 1059 Query: 250 QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLH------HGNAGGG 411 +F NE ++ ++V L G S + +L+V E + +G L HL N G Sbjct: 1060 EFLNEASVMKGFTCHHVVRLLGVVSKGQPMLVVMELMAHGDLKSHLRSLRPDAENNPGRP 1119 Query: 412 DPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 P + + + E A +AYL+A + +HR Sbjct: 1120 PPTL---QEMIQMTAEIADGMAYLNAKKFVHR 1148
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/127 (31%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KG+ + +G + + K G + F D + L H ++V L Sbjct: 713 LGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRL 772 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 773 LGLCPGS--SLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNW------GVQIAKGMYYLE 824 Query: 487 AHQVLHR 507 H ++HR Sbjct: 825 EHSMVHR 831
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 15/136 (11%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHR 507 A+ + YL + +HR Sbjct: 663 IASGMVYLASQHFVHR 678
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 52.8 bits (125), Expect = 5e-07 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 5/125 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRL-YKNSYKGVEQFA---NEVDILSRLRHPNLVALYG 315 LG+G FG VY+G L+ +R+ K+ KG +FA E ++S +H N+V L G Sbjct: 2230 LGSGAFGEVYEGQLQAEDEAQPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLIG 2289 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPL-MLSWPTRLGIAVETAAALAYLHAH 492 + L+ E + G L +L + L L P L + ++ A +Y+ Sbjct: 2290 ICCDTDSISLIMEHMEAGDLLSYLRAARPSSQEALSKLQLPELLSMCLDVANGCSYMEDM 2349 Query: 493 QVLHR 507 +HR Sbjct: 2350 HFVHR 2354
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 52.8 bits (125), Expect = 5e-07 Identities = 39/124 (31%), Positives = 63/124 (50%), Gaps = 3/124 (2%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQ--FANEVDILSRLRHPNLVALYG 315 ++G G +G V+K RD G +VA+KR + V + E+ +L +L+HPNLV+L Sbjct: 9 KIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVSLLE 68 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 R L LV+E+ + T+ L G +PL+ + I +T A+ + H H Sbjct: 69 VFRRKRRLHLVFEYC-HHTVLHELDRYQRGVPEPLVKN------ITWQTLQAVNFCHKHN 121 Query: 496 VLHR 507 +HR Sbjct: 122 CIHR 125
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 52.8 bits (125), Expect = 5e-07 Identities = 30/120 (25%), Positives = 57/120 (47%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + + +A +TA + YLHA ++HR Sbjct: 374 -PGFAIITQWCEGSSLYHHLHVADT------RFDMVQLIDVARQTAQGMDYLHAKNIIHR 426
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 52.8 bits (125), Expect = 5e-07 Identities = 30/120 (25%), Positives = 57/120 (47%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + + +A +TA + YLHA ++HR Sbjct: 374 -PGFAIITQWCEGSSLYHHLHVADT------RFDMVQLIDVARQTAQGMDYLHAKNIIHR 426
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/131 (31%), Positives = 63/131 (48%), Gaps = 3/131 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHR 507 A+ H+H+VLHR Sbjct: 116 AFCHSHRVLHR 126
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 52.8 bits (125), Expect = 5e-07 Identities = 43/134 (32%), Positives = 57/134 (42%), Gaps = 14/134 (10%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSV---VAVKRLYKN-SYKGVEQFANEVDILSRLR-HPNLVALY 312 LG G FG V K +R + AVKR+ S FA E+++L RL H N++ L Sbjct: 822 LGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLL 881 Query: 313 GCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM---------LSWPTRLGIAVETA 465 G L L EF P+G L D L DP LS L + + A Sbjct: 882 GACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFSADVA 941 Query: 466 AALAYLHAHQVLHR 507 ++YL Q +HR Sbjct: 942 RGMSYLSQKQFIHR 955
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 15/136 (11%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHR 507 A+ + YL + +HR Sbjct: 663 IASGMVYLASQHFVHR 678
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 15/136 (11%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHR 507 A+ + YL + +HR Sbjct: 663 IASGMVYLASQHFVHR 678
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 52.8 bits (125), Expect = 5e-07 Identities = 43/152 (28%), Positives = 70/152 (46%), Gaps = 13/152 (8%) Frame = +1 Query: 91 IFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD---GSV---VAVKRLYKN-SYKGVE 249 ++ +E + + ELG G FG VY+G +D G V VAVK + ++ S + Sbjct: 1011 VYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERI 1070 Query: 250 QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLH------HGNAGGG 411 +F NE ++ ++V L G S + L+V E + +G L HL N G Sbjct: 1071 EFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRP 1130 Query: 412 DPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 P + + + E A +AYL+A + +HR Sbjct: 1131 PPTL---QEMIQMTAEIADGMAYLNAKKFVHR 1159
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 15/136 (11%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHR 507 A+ + YL + +HR Sbjct: 663 IASGMVYLASQHFVHR 678 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 49,668,018 Number of Sequences: 219361 Number of extensions: 898291 Number of successful extensions: 5837 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5039 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5283 length of database: 80,573,946 effective HSP length: 104 effective length of database: 57,760,402 effective search space used: 3754426130 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
