ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd14c06 |
|---|---|
| Clone Library Name | barley_pub |
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 224 bits (570), Expect = 2e-58 Identities = 105/174 (60%), Positives = 135/174 (77%), Gaps = 6/174 (3%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 WN RF+I G+ARGLLYLH+DSR RIIHRD+K SN+LLD+NMIPKISDFG+AR+F D+T Sbjct: 624 WNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERDET 683 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 A T+KV+GTYGYMSPEYAM G+FS KSD++SFGV+VLEIV+GKKNRGFY+ + + +LL Sbjct: 684 EANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKKNRGFYNLDYENDLLS 743 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDH------SQVRRCIQVALLCVDMNPRNRP 504 Y W+ WKEGR+ E++D ++ S +V +CIQ+ LLCV +RP Sbjct: 744 YVWSRWKEGRALEIVDPVIVDSLSSQPSIFQPQEVLKCIQIGLLCVQELAEHRP 797
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 135 bits (341), Expect = 6e-32 Identities = 67/168 (39%), Positives = 104/168 (61%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 WNTR +I G ARGL YLH+ +I+RD+K SN+LL + PK+SDFG+A++ Sbjct: 201 WNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSGDK 260 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 T + +V+GTYGY +P+YAM G + KSDIYSFGV++LE++TG+K D NL+G Sbjct: 261 THVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKDQNLVG 320 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 +A L+K+ R+ + + ++ + + + ++ +CV P RP Sbjct: 321 WARPLFKDRRNFPKMVDPLLQGQYPVRGLYQALAISAMCVQEQPTMRP 368
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 131 bits (330), Expect = 1e-30 Identities = 69/170 (40%), Positives = 110/170 (64%), Gaps = 2/170 (1%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R +I G ARGL +LH IIHRD+KASN+LLD + PK++DFG+AR+ ++ Sbjct: 1014 WSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISACES 1073 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRG--FYDAELDLNL 354 T+ + GT+GY+ PEY + K D+YSFGV++LE+VTGK+ G F ++E NL Sbjct: 1074 HVSTV-IAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEPTGPDFKESE-GGNL 1131 Query: 355 LGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 +G+A +G++ +++D ++ + +SQ+ R +Q+A+LC+ P RP Sbjct: 1132 VGWAIQKINQGKAVDVIDPLLVSVALKNSQL-RLLQIAMLCLAETPAKRP 1180
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 125 bits (314), Expect = 9e-29 Identities = 65/168 (38%), Positives = 100/168 (59%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R +I G ARGL +LH IIHRDMK+SNVLLD++ + ++SDFG+AR+ T Sbjct: 956 WSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDT 1015 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + GT GY+ PEY + K D+YS+GV++LE+++GKK + D NL+G Sbjct: 1016 HLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPEEFGEDNNLVG 1075 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 +A L++E R E+LD ++ ++ +++A C+D P RP Sbjct: 1076 WAKQLYREKRGAEILDPELVTDKSGDVELLHYLKIASQCLDDRPFKRP 1123
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 124 bits (312), Expect = 1e-28 Identities = 64/168 (38%), Positives = 100/168 (59%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W TR I G A+GLLYLHE I+HRD+K+SN+LLD N ++DFG+AR+ +T Sbjct: 831 WKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPYET 890 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 T ++GT GY+ PEY V + K D+YSFGV++LE++T K+ + +L+ Sbjct: 891 HVST-DLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKRPVDMCKPKGCRDLIS 949 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 + + E R++E+ D + D ++ R +++A LC+ NP+ RP Sbjct: 950 WVVKMKHESRASEVFDPLIYSKEND-KEMFRVLEIACLCLSENPKQRP 996
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 124 bits (310), Expect = 3e-28 Identities = 64/171 (37%), Positives = 103/171 (60%), Gaps = 3/171 (1%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 WN R +I G A+GL +LH+ + +I+RD K+SN+LLD PK+SDFG+A++ Sbjct: 184 WNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDK 243 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAEL---DLN 351 + + +V+GTYGY +PEYAM G ++KSD+YSFGV+ LE++TG+K D+E+ + N Sbjct: 244 SHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRK---AIDSEMPHGEQN 300 Query: 352 LLGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 L+ +A L+ + R L + + + + + VA +C+ RP Sbjct: 301 LVAWARPLFNDRRKFIKLADPRLKGRFPTRALYQALAVASMCIQEQAATRP 351
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 120 bits (302), Expect = 2e-27 Identities = 65/168 (38%), Positives = 97/168 (57%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R +I G ARGL +LH IIHRDMK+SNVLLD + ++SDFG+AR+ T Sbjct: 958 WAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDT 1017 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + GT GY+ PEY + K D+YS+GV++LE+++GKK + D NL+G Sbjct: 1018 HLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDNNLVG 1077 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 +A L++E R E+LD ++ ++ +++A C+D P RP Sbjct: 1078 WAKQLYREKRGAEILDPELVTDKSGDVELFHYLKIASQCLDDRPFKRP 1125
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 118 bits (295), Expect = 1e-26 Identities = 67/173 (38%), Positives = 102/173 (58%), Gaps = 5/173 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+TR I G A GL YLH D I+HRD+K N+LLD ++ P ISDFGIA++ T Sbjct: 913 WSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSAT 972 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRG-FYDAELDLNLL 357 + + V GT GYM+PE A V S +SD+YS+GV++LE++T KK ++ E D ++ Sbjct: 973 SIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKKALDPSFNGETD--IV 1030 Query: 358 GYAWTLWKE-GRSTELLDEAMMGSSCDHS---QVRRCIQVALLCVDMNPRNRP 504 G+ ++W + G +++D +++ D S QV + +AL C + RP Sbjct: 1031 GWVRSVWTQTGEIQKIVDPSLLDELIDSSVMEQVTEALSLALRCAEKEVDKRP 1083
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 117 bits (293), Expect = 2e-26 Identities = 71/172 (41%), Positives = 101/172 (58%), Gaps = 4/172 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R I G ARGL YLH+ +IIHRD+KA+N+LLD + DFG+A++ + Sbjct: 387 WPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLM-DYKD 445 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAEL----DL 348 T T V GT G+++PEY G S K+D++ +GVM+LE++TG+ R F A L D+ Sbjct: 446 THVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQ--RAFDLARLANDDDV 503 Query: 349 NLLGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 LL + L KE + L+D + G+ D +V + IQVALLC +P RP Sbjct: 504 MLLDWVKGLLKEKKLEALVDVDLQGNYKD-EEVEQLIQVALLCTQSSPMERP 554
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 116 bits (291), Expect = 4e-26 Identities = 67/182 (36%), Positives = 102/182 (56%), Gaps = 14/182 (7%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R +I G A+GL +LH + IIHRDMK+SNVLLD++M ++SDFG+AR+ T Sbjct: 937 WEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDT 996 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + GT GY+ PEY + K D+YS GV++LEI++GK+ + D NL+G Sbjct: 997 HLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDKEEFG-DTNLVG 1055 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHS--------------QVRRCIQVALLCVDMNPRN 498 ++ +EG+ E++DE ++ S ++ R +++AL CVD P Sbjct: 1056 WSKMKAREGKHMEVIDEDLLKEGSSESLNEKEGFEGGVIVKEMLRYLEIALRCVDDFPSK 1115 Query: 499 RP 504 RP Sbjct: 1116 RP 1117
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 114 bits (286), Expect = 2e-25 Identities = 65/177 (36%), Positives = 105/177 (59%), Gaps = 9/177 (5%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R +I+ G ARGL +LH R +I+RD KASN+LLD N K+SDFG+A++ D+ Sbjct: 190 WDLRIKIVIGAARGLAFLHSLQR-EVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEK 248 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG------KKNRGFYDAEL 342 + T +++GTYGY +PEY G +KSD+++FGV++LEI+TG K+ RG ++ + Sbjct: 249 SHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTKRPRG-QESLV 307 Query: 343 DLNLLGYAW---TLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 D W L + R +++D+ + G ++ L C++ +P+NRP Sbjct: 308 D-------WLRPELSNKHRVKQIMDKGIKGQYTT-KVATEMARITLSCIEPDPKNRP 356
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 113 bits (283), Expect = 3e-25 Identities = 62/169 (36%), Positives = 101/169 (59%), Gaps = 1/169 (0%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W TR I G ARGL YLH +IHRD+K+SN+LLD++M K++DFG ++ + Sbjct: 693 WPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGD 752 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + +L+V GT GY+ PEY S KSD++SFGV++LEIV+G++ ++ +L+ Sbjct: 753 SYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRIEWSLVE 812 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQ-VRRCIQVALLCVDMNPRNRP 504 +A + + E++D + G H++ + R ++VAL C++ RP Sbjct: 813 WAKPYIRASKVDEIVDPGIKGGY--HAEALWRVVEVALQCLEPYSTYRP 859
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 113 bits (283), Expect = 3e-25 Identities = 59/169 (34%), Positives = 95/169 (56%), Gaps = 1/169 (0%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W TR I G A GL YLH+ I+HRD+K+SN+LL + ++DFG+AR+ Sbjct: 840 WKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLI-LPYD 898 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 T T ++GT GY+ PEY V + K D+YSFGV++LE++TG++ +L+ Sbjct: 899 THVTTDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTGRRPMDVCKPRGSRDLIS 958 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHS-QVRRCIQVALLCVDMNPRNRP 504 + + E R +E+ D + DH+ ++ +++A C+ NP+ RP Sbjct: 959 WVLQMKTEKRESEIFDPFIYDK--DHAEEMLLVLEIACRCLGENPKTRP 1005
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 112 bits (281), Expect = 6e-25 Identities = 62/169 (36%), Positives = 100/169 (59%), Gaps = 1/169 (0%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W TR I G ARGL YLH +IHRD+K+SN+LLD +M K++DFG ++ + Sbjct: 692 WPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQEGD 751 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + +L+V GT GY+ PEY S KSD++SFGV++LEIV+G++ ++ +L+ Sbjct: 752 SYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRVEWSLVE 811 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQ-VRRCIQVALLCVDMNPRNRP 504 +A + + E++D + G H++ + R ++VAL C++ RP Sbjct: 812 WAKPYIRASKVDEIVDPGIKGGY--HAEALWRVVEVALQCLEPYSTYRP 858
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 112 bits (279), Expect = 1e-24 Identities = 65/169 (38%), Positives = 97/169 (57%), Gaps = 1/169 (0%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R +I G ARGL +LH + IIHRDMK+SNVLLD N+ ++SDFG+AR+ T Sbjct: 985 WPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDT 1044 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + GT GY+ PEY S K D+YS+GV++LE++TGK+ D D NL+G Sbjct: 1045 HLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTDSADFG-DNNLVG 1103 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCD-HSQVRRCIQVALLCVDMNPRNRP 504 + L +G+ T++ D ++ ++ + ++VA C+D RP Sbjct: 1104 WV-KLHAKGKITDVFDRELLKEDASIEIELLQHLKVACACLDDRHWKRP 1151
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 112 bits (279), Expect = 1e-24 Identities = 65/169 (38%), Positives = 97/169 (57%), Gaps = 1/169 (0%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R +I G ARGL +LH + IIHRDMK+SNVLLD N+ ++SDFG+AR+ T Sbjct: 985 WPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDT 1044 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + GT GY+ PEY S K D+YS+GV++LE++TGK+ D D NL+G Sbjct: 1045 HLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTDSADFG-DNNLVG 1103 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCD-HSQVRRCIQVALLCVDMNPRNRP 504 + L +G+ T++ D ++ ++ + ++VA C+D RP Sbjct: 1104 WV-KLHAKGKITDVFDRELLKEDASIEIELLQHLKVACACLDDRHWKRP 1151
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 111 bits (278), Expect = 1e-24 Identities = 67/171 (39%), Positives = 95/171 (55%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+TR +I G ARGL +LH + IIHRDMK+SNVLLD N+ ++SDFG+AR+ T Sbjct: 980 WSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDT 1039 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + GT GY+ PEY S K D+YS+GV++LE++TGK+ D D NL+G Sbjct: 1040 HLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFG-DNNLVG 1098 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPPHV 513 + K S E M ++ + ++VA+ C+D RP V Sbjct: 1099 WVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMV 1149
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 110 bits (274), Expect = 4e-24 Identities = 63/172 (36%), Positives = 105/172 (61%), Gaps = 4/172 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 WNTR + G ARGL +LH +++ ++I+RD KASN+LLD N K+SDFG+AR Sbjct: 175 WNTRVRMALGAARGLAFLH-NAQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPMGDN 233 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + + +V+GT GY +PEY G S+KSD+YSFGV++LE+++G++ + NL+ Sbjct: 234 SHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKNQPVGEHNLVD 293 Query: 361 YAWT-LWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALL---CVDMNPRNRP 504 +A L + R ++D + G + R +++A+L C+ ++ ++RP Sbjct: 294 WARPYLTNKRRLLRVMDPRLQG----QYSLTRALKIAVLALDCISIDAKSRP 341
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 106 bits (264), Expect = 5e-23 Identities = 58/175 (33%), Positives = 93/175 (53%), Gaps = 7/175 (4%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W TR + A+GL YLH D I+HRD+K++N+LLD + ++DFG+A+ Sbjct: 788 WETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLVDGAA 847 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + + G+YGY++PEYA KSD+YSFGV++LE++ GKK G + +D+ Sbjct: 848 SECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGKKPVGEFGEGVDI---- 903 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDH-------SQVRRCIQVALLCVDMNPRNRP 504 W E T+ D A++ + D + V ++A++CV+ RP Sbjct: 904 VRWVRNTEEEITQPSDAAIVVAIVDPRLTGYPLTSVIHVFKIAMMCVEEEAAARP 958
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 102 bits (253), Expect = 1e-21 Identities = 58/181 (32%), Positives = 99/181 (54%), Gaps = 2/181 (1%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R + +ARG+ YLH + IHRD+K SN+LL +M K++DFG+ R+ + Sbjct: 688 WKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKG 747 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + T ++ GT+GY++PEYA+ G + K D+YSFGV+++E++TG+K+ E ++L+ Sbjct: 748 SIET-RIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRKSLDESQPEESIHLVS 806 Query: 361 YAWTLW--KEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPPHVFNCHDVG 534 + ++ KE + +D + + V ++A C P RP D+G Sbjct: 807 WFKRMYINKEASFKKAIDTTIDLDEETLASVHTVAELAGHCCAREPYQRP-------DMG 859 Query: 535 H 537 H Sbjct: 860 H 860
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 101 bits (251), Expect = 2e-21 Identities = 63/171 (36%), Positives = 94/171 (54%), Gaps = 3/171 (1%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARM--FGGD 174 W R I A GL YLH D I+HRD+K+SN+LLD + K++DFGIA++ G Sbjct: 790 WPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGS 849 Query: 175 QTTAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAEL-DLN 351 +T + G+ GY++PEY + KSDIYSFGV++LE+VTGK+ D+EL D + Sbjct: 850 KTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQPT---DSELGDKD 906 Query: 352 LLGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 + + T + ++D + ++ + I + LLC P NRP Sbjct: 907 MAKWVCTALDKCGLEPVIDPKL--DLKFKEEISKVIHIGLLCTSPLPLNRP 955
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 100 bits (248), Expect = 4e-21 Identities = 66/174 (37%), Positives = 95/174 (54%), Gaps = 6/174 (3%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+TR ++ G A G+ +LHE+ IHRD+K++N+LLD++ KISDFG+AR Sbjct: 285 WHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASARLAQ 341 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLN--- 351 T T +++GT YM+PE A+ G + KSDIYSFGV++LE++TG A +D N Sbjct: 342 TVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSFGVVLLELITGL-------AAVDENREP 393 Query: 352 --LLGYAWTLWKEGRSTE-LLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 LL + E ++ E DE M S D + V A C+ RP Sbjct: 394 QLLLDIKEEIEDEEKTIEDYTDEKM--SDADPASVEAMYSAASQCLHEKKNRRP 445
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 99.0 bits (245), Expect = 9e-21 Identities = 60/168 (35%), Positives = 93/168 (55%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R I ARG+ YLH + +IHRD+K+SN+L+D + +++DFG++ + D Sbjct: 605 WARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSG 664 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 T + GT GY+ PEY + KSD+YSFGV++LEI++G+K E N++ Sbjct: 665 TPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQFEE--GNIVE 722 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 +A L K G +LD + S D +++ VA CV M ++RP Sbjct: 723 WAVPLIKAGDIFAILDPVLSPPS-DLEALKKIASVACKCVRMRGKDRP 769
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 98.6 bits (244), Expect = 1e-20 Identities = 56/175 (32%), Positives = 93/175 (53%), Gaps = 7/175 (4%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W RF I G+A+GL YLH + +IH D+K N+LLD+ PKI+DFG+ ++ + Sbjct: 629 WEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGS 688 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNR----GFYDAELDL 348 T V GT GY++PE+ + K D+YS+GV++LE++TG + G + L Sbjct: 689 TQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTRVSELVGGTDEVHSML 748 Query: 349 NLLGYAWTLWKEGRSTELLD---EAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 L + EG +D ++ + ++ Q R I++A+ C++ + RP Sbjct: 749 RKLVRMLSAKLEGEEQSWIDGYLDSKLNRPVNYVQARTLIKLAVSCLEEDRSKRP 803
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 97.1 bits (240), Expect = 3e-20 Identities = 62/173 (35%), Positives = 91/173 (52%), Gaps = 5/173 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W RF I G ARG+ +LH +IH D+K +N+LLD+ + PKI DFG+ R Sbjct: 317 WQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLD 376 Query: 181 TAYTL-KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK-NRGFYDAELDLNL 354 + KV GT Y+ PE+ S D+YSFG+++LE+ TG++ + E NL Sbjct: 377 AVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNL 436 Query: 355 LGYAWTLWKEGRSTELLDE---AMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 L Y W++ R ELL++ A MG D I+ L C ++P++RP Sbjct: 437 LDYVKQQWRQNR-MELLEKHLAAPMGKELDMCMC--AIEAGLHCTALDPQDRP 486
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 95.9 bits (237), Expect = 7e-20 Identities = 45/105 (42%), Positives = 70/105 (66%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R ++ G A+GL +LH S R+I+RD K SN+LLD K+SDFG+A+ Sbjct: 175 WKLRLKVALGAAKGLAFLHS-SETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIGDK 233 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 + + +V+GT+GY +PEY G + KSD+YSFGV++LE+++G++ Sbjct: 234 SHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRR 278
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 95.5 bits (236), Expect = 1e-19 Identities = 50/103 (48%), Positives = 69/103 (66%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R +I G A G+ +LHE+ IHRD+K++N+LLD KISDFG+AR Sbjct: 285 WHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQ 341 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG 309 T T +++GT YM+PE A+ G + KSDIYSFGV++LEI+TG Sbjct: 342 TVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSFGVVLLEIITG 383
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 94.4 bits (233), Expect = 2e-19 Identities = 42/105 (40%), Positives = 70/105 (66%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R ++ G A+GL +LH ++ +I+RD K SN+LLD K+SDFG+A+ Sbjct: 176 WTLRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTGDK 234 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 + + +++GTYGY +PEY G + KSD+YS+GV++LE+++G++ Sbjct: 235 SHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRR 279
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 92.0 bits (227), Expect = 1e-18 Identities = 50/168 (29%), Positives = 89/168 (52%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R +I A+GL YLH + I+HRD+K +N+LL+ + K++DFG++R F + + Sbjct: 668 WEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGS 727 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + V G+ GY+ PEY + KSD+YS GV++LE++TG+ E +++ Sbjct: 728 GQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQPAIASSKTE-KVHISD 786 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 + ++ G ++D+ + D + ++AL C + RP Sbjct: 787 HVRSILANGDIRGIVDQRLR-ERYDVGSAWKMSEIALACTEHTSAQRP 833
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 89.0 bits (219), Expect = 9e-18 Identities = 47/112 (41%), Positives = 69/112 (61%), Gaps = 7/112 (6%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARM--FGG- 171 W R +I+ G AR + +LH+DS +IH D+K+SNVLLD ++PK+ DFG+AR F G Sbjct: 312 WPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGA 370 Query: 172 ----DQTTAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 T A T V GT Y+ EY G ++ +D +SFGV++LE + G++ Sbjct: 371 KASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQR 422
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 86.7 bits (213), Expect = 4e-17 Identities = 47/112 (41%), Positives = 68/112 (60%), Gaps = 7/112 (6%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARM--FGGD 174 W R +I+ G AR + +LH+DS +IH D+K+SNVLLD + PK+ DFG+AR F G Sbjct: 312 WPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGS 370 Query: 175 QTT-----AYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 + A T V GT Y+ EY G ++ +D +SFGV+VLE + G++ Sbjct: 371 SPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQR 422
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 81.3 bits (199), Expect = 2e-15 Identities = 45/102 (44%), Positives = 68/102 (66%), Gaps = 8/102 (7%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDR--------NMIPKISDFGIARMFGGDQTTA 186 IARG+LYLHE++ + I+HRD+K+SN+LL N KI+DFG+AR + +TT Sbjct: 244 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW--HRTT- 300 Query: 187 YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GTY +M+PE +FS SDI+S+GV++ E++TG+ Sbjct: 301 -KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGE 341
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 78.6 bits (192), Expect = 1e-14 Identities = 42/99 (42%), Positives = 62/99 (62%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 EI + + R L + H++ +IIHRD+K N+L+ + K++DFGIAR G T YT Sbjct: 113 EIASQVCRALDHAHKN---KIIHRDIKPQNILVTDEDVVKVTDFGIARAANG-ATITYTG 168 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 VIGT Y SPE A + ++DIYS G+++ E++TGK Sbjct: 169 DVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGK 207
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 78.6 bits (192), Expect = 1e-14 Identities = 43/102 (42%), Positives = 69/102 (67%), Gaps = 8/102 (7%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDR--------NMIPKISDFGIARMFGGDQTTA 186 IARG+ YLH+++ + IIHRD+K+SN+L+ + N I KI+DFG+AR + +TT Sbjct: 249 IARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW--HRTTK 306 Query: 187 YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GTY +M+PE +FS SD++S+GV++ E++TG+ Sbjct: 307 --MSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGE 346
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 76.6 bits (187), Expect = 5e-14 Identities = 36/109 (33%), Positives = 63/109 (57%), Gaps = 4/109 (3%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R ++ GIA+ + YLH +I ++ ++N+LLD + PK++DF A + Sbjct: 277 WHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQ 336 Query: 181 TAYTLKVIG----TYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 + T+ + G YM EY G S+K+D+YSFG++++E++TG K Sbjct: 337 QSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCK 385
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 76.3 bits (186), Expect = 6e-14 Identities = 42/102 (41%), Positives = 68/102 (66%), Gaps = 8/102 (7%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLL-----DRNM---IPKISDFGIARMFGGDQTTA 186 +ARG+ YLH D+ + IIHRD+K+ N+L+ + N+ + KI+DFG+AR + +TT Sbjct: 203 VARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW--HKTTK 260 Query: 187 YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GTY +M+PE +FS SD++SFGV++ E++TG+ Sbjct: 261 --MSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE 300
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 75.1 bits (183), Expect = 1e-13 Identities = 49/167 (29%), Positives = 86/167 (51%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 +N + T IA+ L + H++ I+HRD+K N+++ + I K++DFGIA+ + T Sbjct: 107 FNKIIDYATQIAKALNFAHKNG---IVHRDIKPHNIMVTDDDIIKVTDFGIAKA-SNEST 162 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 T KV+G+ Y+SPE A ++DIYSFG+++ E+ TGK YDA+ +++ Sbjct: 163 ITTTNKVVGSAHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVP---YDADTPVSI-- 217 Query: 361 YAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNR 501 + D A+ + + ++ L C++ P NR Sbjct: 218 ---------ALKHIQDAAVPPNELNKDIPIALNKMILRCIEKKPENR 255
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/98 (43%), Positives = 57/98 (58%), Gaps = 1/98 (1%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG-GDQTTAYT 192 E+ GI + L Y H R I+HRD+K +NV+L RN K+ DFGIAR G T T Sbjct: 117 EMTIGILQALEYSH---RAGIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQT 173 Query: 193 LKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 VIGT Y+SPE A +SD+YS G ++ E++T Sbjct: 174 AAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLT 211
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 73.9 bits (180), Expect = 3e-13 Identities = 40/102 (39%), Positives = 63/102 (61%), Gaps = 8/102 (7%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVL----LDRNMIP----KISDFGIARMFGGDQTTA 186 IARG+ YLH ++ + IIHRD+K+SNVL ++ N + KI+DFG+AR + Sbjct: 245 IARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR----EMYNT 300 Query: 187 YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GTY +M PE +S SD++S+GV++ E++TG+ Sbjct: 301 QRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGE 342
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 73.2 bits (178), Expect = 5e-13 Identities = 37/99 (37%), Positives = 56/99 (56%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 EI+ + L + H++ IIHRD+K +N+++ K+ DFGIAR + T Sbjct: 117 EIVADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSTSVTQTA 173 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 VIGT Y+SPE A +SD+YS G ++ EI+TG+ Sbjct: 174 AVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGE 212
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 72.8 bits (177), Expect = 7e-13 Identities = 41/102 (40%), Positives = 66/102 (64%), Gaps = 8/102 (7%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDR--------NMIPKISDFGIARMFGGDQTTA 186 IARG+ YLH ++ + +IHRD+K++N+LL + + KI+DFG+AR + +TT Sbjct: 222 IARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREW--HKTTQ 279 Query: 187 YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GTY +M+PE FS SD++SFGV++ E++TG+ Sbjct: 280 --MSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGE 319
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/132 (32%), Positives = 69/132 (52%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I + RGL YLHE ++IHRD+K N+LL+ N K+ DFG++ G+ + Sbjct: 328 KIAEAVLRGLSYLHEK---KVIHRDIKPQNILLNENGQVKLCDFGVS----GEAVNSLAT 380 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTL 375 GT YM+PE +S+ SD++S G+ +LE+ GK ++ N+ + + Sbjct: 381 TFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCS--SEKMAANIAPFELLM 438 Query: 376 WKEGRSTELLDE 411 W + EL DE Sbjct: 439 WILTFTPELKDE 450
>BYR1_SCHPO (P10506) Protein kinase byr1 (EC 2.7.12.2) (MAPK kinase) (MAPKK)| Length = 340 Score = 72.0 bits (175), Expect = 1e-12 Identities = 39/114 (34%), Positives = 68/114 (59%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +II + +GL+YL+ + L IIHRD+K SNV+++ K+ DFG++ G+ + Sbjct: 164 KIINSMVKGLIYLY--NVLHIIHRDLKPSNVVVNSRGEIKLCDFGVS----GELVNSVAQ 217 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLL 357 +GT YMSPE G +++KSDI+S G+ ++E+ T + F + + + +L Sbjct: 218 TFVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQELPWSFSNIDDSIGIL 271
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 71.6 bits (174), Expect = 1e-12 Identities = 37/97 (38%), Positives = 65/97 (67%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 372 IAAGMAYIE---RMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPI 428 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 429 K------WTAPEAALFGKFTIKSDVWSFGILLTELVT 459
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 71.6 bits (174), Expect = 1e-12 Identities = 37/100 (37%), Positives = 58/100 (58%), Gaps = 1/100 (1%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT-AYT 192 +++ G+ L Y H R+ IIHRD+K N+++ + K+ DFGIAR T + Sbjct: 125 QVMLGVLNALDYSH---RMGIIHRDIKPGNIMISEQGVVKVMDFGIARALDDSAATMTQS 181 Query: 193 LKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 V+GT Y+SPE A M+SD+YS G ++ E++TG+ Sbjct: 182 QGVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYEMLTGR 221
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 71.6 bits (174), Expect = 1e-12 Identities = 34/107 (31%), Positives = 61/107 (57%), Gaps = 4/107 (3%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R I+ GI++ + YLH +I + ++N+LLD PK++DF +A + Sbjct: 264 WHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEH 323 Query: 181 TAYTLKVIGTYG----YMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG 309 + T+ + + YM EY G S+K+D+YSFG++++E++TG Sbjct: 324 QSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 71.2 bits (173), Expect = 2e-12 Identities = 36/98 (36%), Positives = 61/98 (62%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ I + + H++ +I+HRD+K N+L+D K++DFGIA T +T Sbjct: 114 IMEQIVSAIAHAHQN---QIVHRDIKPHNILIDHMGNIKVTDFGIATALSST-TITHTNS 169 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 V+G+ Y+SPE A G+ + KSDIY+ G+++ E++TG+ Sbjct: 170 VLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGR 207
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 70.9 bits (172), Expect = 3e-12 Identities = 36/97 (37%), Positives = 65/97 (67%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 +ARG+ Y+ R+ IHRD++++N+L+ +I KI+DFG+AR+ ++ TA + + Sbjct: 373 VARGMAYIE---RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPI 429 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 430 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 460
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 70.9 bits (172), Expect = 3e-12 Identities = 37/97 (38%), Positives = 65/97 (67%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 370 IADGMAYIE---RMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPI 426 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 427 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 457
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 70.9 bits (172), Expect = 3e-12 Identities = 38/97 (39%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N+I KI+DFG+AR+ ++ TA + + Sbjct: 377 IADGMAYIE---RMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPI 433 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG++ E+VT Sbjct: 434 K------WTAPEAALYGRFTIKSDVWSFGILQTELVT 464
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 70.9 bits (172), Expect = 3e-12 Identities = 37/97 (38%), Positives = 65/97 (67%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 377 IADGMAYIE---RMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPI 433 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 434 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 464
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 70.5 bits (171), Expect = 3e-12 Identities = 40/94 (42%), Positives = 53/94 (56%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I G+LYLH I+HRD+ SN+LL RNM KI+DFG+A YTL GT Sbjct: 120 IITGMLYLHSHG---ILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTL--CGT 174 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 Y+SPE A ++SDI+S G M ++ G+ Sbjct: 175 PNYISPEIATRSAHGLESDIWSLGCMFYTLLIGR 208
>STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC 2.7.12.2)| Length = 515 Score = 70.5 bits (171), Expect = 3e-12 Identities = 37/99 (37%), Positives = 61/99 (61%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I G+ GL +L+ + +IIHRD+K SNVL++ K+ DFG+++ + Sbjct: 309 KIAYGVLNGLDHLYR--QYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTF-- 364 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE V+S+K D++S G+M++E+VTG+ Sbjct: 365 --VGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGE 401
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 70.5 bits (171), Expect = 3e-12 Identities = 37/97 (38%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 379 IADGMAYIE---RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPI 435 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG++ E+VT Sbjct: 436 K------WTAPEAALYGRFTIKSDVWSFGILQTELVT 466
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 70.1 bits (170), Expect = 4e-12 Identities = 37/108 (34%), Positives = 64/108 (59%), Gaps = 3/108 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W R +I GIARGL YLH + IIH ++++ NVL+D ++++FG+ ++ Sbjct: 471 WARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKI----MV 526 Query: 181 TAYTLKVIG---TYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 A +++ + GY +PE + +SD+Y+FG+++LEI+ GKK Sbjct: 527 QAVADEIVSQAKSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKK 574
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 70.1 bits (170), Expect = 4e-12 Identities = 31/94 (32%), Positives = 56/94 (59%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I L Y+H ++HRD+K SN+++D + ++ DFG+A+ D K++GT Sbjct: 228 ICEALAYIHGHG---LVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLVGT 284 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 Y YM+PE + ++D+YS GV++ E+++G+ Sbjct: 285 YRYMAPEQILGEPLDGRADLYSLGVILYELLSGR 318
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 70.1 bits (170), Expect = 4e-12 Identities = 35/107 (32%), Positives = 65/107 (60%), Gaps = 2/107 (1%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W ++ + G+ YLH+ + + ++HRD+K SNVL D + K++DFG++ GG Q+ Sbjct: 114 WPLLCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQS 172 Query: 181 TAYTLKVIGTYGYMSPE--YAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 + + GT GY++PE ++ S SD+YSFG+++ ++ G++ Sbjct: 173 GTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE 219
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 70.1 bits (170), Expect = 4e-12 Identities = 35/102 (34%), Positives = 66/102 (64%), Gaps = 5/102 (4%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA--- 186 E+ IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA Sbjct: 361 EMAAQIASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARPG 417 Query: 187 --YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 418 ARFPVK------WTAPEAALYGRFTIKSDVWSFGILLTELTT 453
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 69.7 bits (169), Expect = 6e-12 Identities = 35/97 (36%), Positives = 65/97 (67%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 +A G+ Y+ R+ IHRD++++N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 373 VAAGMAYIE---RMNYIHRDLRSANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPI 429 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 430 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 460
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 69.7 bits (169), Expect = 6e-12 Identities = 38/102 (37%), Positives = 65/102 (63%) Frame = +1 Query: 10 RFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAY 189 + +++ G A G+ YLH + + I+HRD+K +N+L+D + KI+DFG AR+ D T Sbjct: 1462 KLKLLYGAAMGIDYLHSSNPM-IVHRDIKPANILVDEHFNVKIADFGFARI-KEDNT--- 1516 Query: 190 TLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 T+ GT + +PE + K+D++SFGV++ E++TGK+ Sbjct: 1517 TMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKE 1558 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/145 (26%), Positives = 80/145 (55%), Gaps = 4/145 (2%) Frame = +1 Query: 34 ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTY 213 ++G+ +LH I+HRD+K+ N+LLD K+SDFG+ ++ +IGT Sbjct: 893 SKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTI 949 Query: 214 GYMSPEYAMDG--VFSMKSDIYSFGVMVLEIVTGKK-NRGFYDAELDLNLLGYAWTLWKE 384 +++PE D V + +D+YSFG+++ E++T ++ +G A + ++++ ++ Sbjct: 950 HWIAPEILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVI-------RD 1002 Query: 385 GRSTELLDEAMMGSSCDH-SQVRRC 456 G + DEA+ S ++ +++C Sbjct: 1003 GMRPPISDEAVTAHSIEYIDLIKQC 1027
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 69.3 bits (168), Expect = 7e-12 Identities = 36/102 (35%), Positives = 68/102 (66%), Gaps = 5/102 (4%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA--- 186 ++ + IA G+ ++ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA Sbjct: 375 DMASQIADGMAFIE---RMNYIHRDLRAANILVADNLVCKIADFGLARLIEDNEYTARQG 431 Query: 187 --YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 432 AKFPIK------WTAPEAALYGRFTIKSDVWSFGILLTELVT 467
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 369 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 425 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 426 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 372 IASGMAYV---DRMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 428 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 429 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 459
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 372 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 428 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 429 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 459
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 377 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 433 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 434 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 464
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 69.3 bits (168), Expect = 7e-12 Identities = 35/97 (36%), Positives = 63/97 (64%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARM-----FGGDQTTAYTL 195 +A G+ Y+ R+ IHRD++A+N+L+ +I KI+DFG+AR+ + Q T + + Sbjct: 354 VAEGMAYME---RMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPI 410 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E++T Sbjct: 411 K------WTAPEAALFGRFTVKSDVWSFGILLTELIT 441
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 368 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 424 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 425 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 455
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 69.3 bits (168), Expect = 7e-12 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ +HRD++A+N+L+ N++ K++DFG+AR+ ++ TA + + Sbjct: 368 IASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 424 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+ T Sbjct: 425 K------WTAPEAALYGRFTIKSDVWSFGILLTELTT 455
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 68.9 bits (167), Expect = 1e-11 Identities = 43/100 (43%), Positives = 61/100 (61%), Gaps = 1/100 (1%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 + T + +GL YLH I+HRDMKA N+LLD++ I KISDFGI+R D + + Sbjct: 1283 LTTQVLKGLAYLHSKG---ILHRDMKADNLLLDQDGICKISDFGISRK-SKDIYSNSDMT 1338 Query: 199 VIGTYGYMSPEYA-MDGVFSMKSDIYSFGVMVLEIVTGKK 315 + GT +M+PE +S K DI+S G +VLE+ GK+ Sbjct: 1339 MRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKR 1378
>PKSC_STRCO (Q9S2C0) Serine/threonine protein kinase pksC (EC 2.7.11.1)| Length = 556 Score = 68.9 bits (167), Expect = 1e-11 Identities = 35/91 (38%), Positives = 55/91 (60%), Gaps = 1/91 (1%) Frame = +1 Query: 43 LLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIAR-MFGGDQTTAYTLKVIGTYGY 219 L L + ++HRD+K NV++ + + K+ DFGIAR M G + T V+GT Y Sbjct: 136 LAALEISHEMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQY 195 Query: 220 MSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +SPE A+ +SD+YS G+M+ ++VTG+ Sbjct: 196 LSPEQALGRGVDARSDLYSVGIMLFQLVTGR 226
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 68.9 bits (167), Expect = 1e-11 Identities = 36/96 (37%), Positives = 64/96 (66%), Gaps = 5/96 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 373 IADGMAYIE---RMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPI 429 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIV 303 K + +PE A+ G F++KSD++SFG+++ E+V Sbjct: 430 K------WTAPEAALYGRFTIKSDVWSFGILLTELV 459
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 68.9 bits (167), Expect = 1e-11 Identities = 39/108 (36%), Positives = 63/108 (58%), Gaps = 3/108 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQ- 177 W ++ + G+ YLH + ++HRD+K SNVLLD + K++DFG++ GG Q Sbjct: 115 WPLLCRLLEEVVLGMCYLHSLNP-SLLHRDLKPSNVLLDLELHAKLADFGLSTFQGGSQS 173 Query: 178 -TTAYTLKVIGTYGYMSPEYA-MDGVFSMKSDIYSFGVMVLEIVTGKK 315 + + + GT Y++PE DG S SD+YSFGV+V ++ G++ Sbjct: 174 GSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGRE 221
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 68.9 bits (167), Expect = 1e-11 Identities = 40/96 (41%), Positives = 57/96 (59%) Frame = +1 Query: 25 TGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVI 204 TGIA G+ YLH +IIHRD+K+ NVL+ KISDFG ++ T + Sbjct: 261 TGIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK---MSFA 314 Query: 205 GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 GT +M+PE + S K DI+SFGV++ E++TG+ Sbjct: 315 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGE 350
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 68.9 bits (167), Expect = 1e-11 Identities = 36/97 (37%), Positives = 63/97 (64%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R+ IHRD++A+N+L+ N++ KI+DFG+AR+ ++ TA + + Sbjct: 375 IADGMAYIE---RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPI 431 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG++ E+ T Sbjct: 432 K------WTAPEAALYGRFTIKSDVWSFGILQTELTT 462
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 68.6 bits (166), Expect = 1e-11 Identities = 35/92 (38%), Positives = 59/92 (64%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 IA G+ Y+ R+ IHRD++A+N+L+ + KI+DFG+AR+ + T K Sbjct: 343 IAEGMAYIE---RMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKF--P 397 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +PE GVF++K+D++SFGV+++E+VT Sbjct: 398 IKWTAPEAIHFGVFTIKADVWSFGVLLMEVVT 429
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 68.6 bits (166), Expect = 1e-11 Identities = 35/97 (36%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 +A G+ Y+ R+ IHRD++++N+L+ +I KI+DFG+AR+ ++ TA + + Sbjct: 373 VAAGMAYIE---RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPI 429 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 430 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 460
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 68.6 bits (166), Expect = 1e-11 Identities = 35/97 (36%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 +A G+ Y+ R+ IHRD++++N+L+ +I KI+DFG+AR+ ++ TA + + Sbjct: 370 VAAGMAYIE---RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPI 426 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 427 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 457
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 68.6 bits (166), Expect = 1e-11 Identities = 35/97 (36%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 +A G+ Y+ R+ IHRD++++N+L+ +I KI+DFG+AR+ ++ TA + + Sbjct: 370 VAAGMAYIE---RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPI 426 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+VT Sbjct: 427 K------WTAPEAALYGRFTIKSDVWSFGILLTELVT 457
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 68.6 bits (166), Expect = 1e-11 Identities = 50/169 (29%), Positives = 81/169 (47%) Frame = +1 Query: 55 HEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEY 234 H SR R++HRD+K +NV + + K+ D G+ R F T A++L +GT YMSPE Sbjct: 151 HMHSR-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSL--VGTPYYMSPER 207 Query: 235 AMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLDEA 414 + ++ KSDI+S G ++ E+ A L G L+ + E D Sbjct: 208 IHENGYNFKSDIWSLGCLLYEM-----------AALQSPFYGDKMNLYSLCKKIEQCDYP 256 Query: 415 MMGSSCDHSQVRRCIQVALLCVDMNPRNRPPHVFNCHDVGHRECHAARA 561 + S ++R+ + + C++ +P RP + +DV R HA A Sbjct: 257 PLPSDHYSEELRQLVNI---CINPDPEKRPDIAY-VYDVAKR-MHACTA 300
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 68.6 bits (166), Expect = 1e-11 Identities = 36/100 (36%), Positives = 56/100 (56%), Gaps = 1/100 (1%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGD-QTTAYT 192 E+I + L + H++ IIHRD+K +N+++ K+ DFGIAR + T Sbjct: 117 EVIADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQT 173 Query: 193 LKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 VIGT Y+SPE A +SD+YS G ++ E++TG+ Sbjct: 174 AAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGE 213
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 68.6 bits (166), Expect = 1e-11 Identities = 36/100 (36%), Positives = 56/100 (56%), Gaps = 1/100 (1%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGD-QTTAYT 192 E+I + L + H++ IIHRD+K +N+++ K+ DFGIAR + T Sbjct: 117 EVIADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQT 173 Query: 193 LKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 VIGT Y+SPE A +SD+YS G ++ E++TG+ Sbjct: 174 AAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGE 213
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 68.6 bits (166), Expect = 1e-11 Identities = 39/94 (41%), Positives = 53/94 (56%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I G+LYLH I+HRD+ SN+LL RNM KI+DFG+A YTL GT Sbjct: 120 IITGMLYLHSHG---ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTL--CGT 174 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 Y+SPE A ++SD++S G M ++ G+ Sbjct: 175 PNYISPEIATRSAHGLESDVWSLGCMFYTLLIGR 208
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 68.2 bits (165), Expect = 2e-11 Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 6/120 (5%) Frame = +1 Query: 16 EIITGIARGLLYLHE------DSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQ 177 +++ A GL Y HE L +IHRD+ N+L+ R K+ DFGIA++ G Sbjct: 113 KVVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKVVDFGIAKVAGQGH 172 Query: 178 TTAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLL 357 T T V G YM PE + D+Y+ GV++ E++TGK+ +DA D++++ Sbjct: 173 RT-LTGVVKGKVAYMPPEQLQAKAMDRRVDVYALGVVLYELLTGKRP---FDATTDVSVM 228
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 68.2 bits (165), Expect = 2e-11 Identities = 44/103 (42%), Positives = 55/103 (53%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N E IA L YLHE I+HRD+K NV L R I K+ D GIAR+ Sbjct: 106 NQVVEWFVQIAMALQYLHEK---HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDM 162 Query: 184 AYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 A TL IGT YMSPE + ++ KSD+++ G V E+ T K Sbjct: 163 ASTL--IGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLK 203
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 68.2 bits (165), Expect = 2e-11 Identities = 34/98 (34%), Positives = 61/98 (62%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I + RGL YL ++ ++I+HRD+K SN+L++ N K+ DFG++ M ++ Sbjct: 174 ISVAVVRGLTYLKDE--IKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSF--- 228 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YM+PE +++ SDI+SFG+ ++E++ G+ Sbjct: 229 -VGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGR 265
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 68.2 bits (165), Expect = 2e-11 Identities = 52/169 (30%), Positives = 81/169 (47%) Frame = +1 Query: 55 HEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEY 234 H SR R++HRD+K +NV + + K+ D G+ R F T A++L +GT YMSPE Sbjct: 151 HMHSR-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSL--VGTPYYMSPER 207 Query: 235 AMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLDEA 414 + ++ KSDI+S G ++ E+ A L G L+ + E D Sbjct: 208 IHENGYNFKSDIWSLGCLLYEM-----------AALQSPFYGDKMNLYSLCKKIEQCDYP 256 Query: 415 MMGSSCDHSQVRRCIQVALLCVDMNPRNRPPHVFNCHDVGHRECHAARA 561 + S ++R Q+ +C++ +P R P V +DV R HA A Sbjct: 257 PLPSDHYSEELR---QLVNMCINPDPEKR-PDVTYVYDVAKR-MHACTA 300
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/94 (44%), Positives = 53/94 (56%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 IA L YLHE I+HRD+K NV L R I K+ D GIAR+ A TL IGT Sbjct: 115 IAMALQYLHEK---HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTL--IGT 169 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 YMSPE + ++ KSD+++ G V E+ T K Sbjct: 170 PYYMSPELFSNKPYNYKSDVWALGCCVYEMATLK 203
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 67.8 bits (164), Expect = 2e-11 Identities = 51/178 (28%), Positives = 81/178 (45%), Gaps = 9/178 (5%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGD-----QTT 183 I T +A G+ YL ++IHRD+ A NVL+ N + KI DFG+AR+ D Q + Sbjct: 384 IATQVASGMEYLESK---QLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGS 440 Query: 184 AYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGY 363 + +K + +PE + G FS+KSD++S+G++++E+ T Y Sbjct: 441 RFPVK------WTAPEAIIYGKFSIKSDVWSYGILLMELFT------------------Y 476 Query: 364 AWTLWKEGRSTELLDEAMMG----SSCDHSQVRRCIQVALLCVDMNPRNRPPHVFNCH 525 + S E+++ G +H Q+ L C D P RP F H Sbjct: 477 GQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNH 534
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 67.8 bits (164), Expect = 2e-11 Identities = 35/94 (37%), Positives = 61/94 (64%) Frame = +1 Query: 25 TGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVI 204 T +A+G+ YLH ++ +++IHRD+K+ NV++ + + KI DFG +R + TT +L + Sbjct: 112 TDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH--NHTTHMSL--V 167 Query: 205 GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 GT+ +M+PE S D YS+GV++ E++T Sbjct: 168 GTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT 201
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 67.8 bits (164), Expect = 2e-11 Identities = 35/94 (37%), Positives = 61/94 (64%) Frame = +1 Query: 25 TGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVI 204 T +A+G+ YLH ++ +++IHRD+K+ NV++ + + KI DFG +R + TT +L + Sbjct: 112 TDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH--NHTTHMSL--V 167 Query: 205 GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 GT+ +M+PE S D YS+GV++ E++T Sbjct: 168 GTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT 201
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 67.8 bits (164), Expect = 2e-11 Identities = 39/96 (40%), Positives = 57/96 (59%) Frame = +1 Query: 25 TGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVI 204 TGIA G+ YLH +IIHRD+K+ NVL+ KISDFG ++ T + Sbjct: 261 TGIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST---KMSFA 314 Query: 205 GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 GT +++PE + S K DI+SFGV++ E++TG+ Sbjct: 315 GTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGE 350
>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) Length = 984 Score = 67.8 bits (164), Expect = 2e-11 Identities = 44/144 (30%), Positives = 72/144 (50%), Gaps = 1/144 (0%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS 255 I+HRD+K N+ L + + K+ D+G+A+ + + A TL +GT YMSPE ++ Sbjct: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETL--VGTPYYMSPELCQGVKYN 229 Query: 256 MKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLDEAMMGSSCD 435 KSDI++ G ++ E++T K+ +DA LNL + + + D Sbjct: 230 FKSDIWAVGCVIFELLTLKRT---FDATNPLNL-------------CVKIVQGIRAMEVD 273 Query: 436 HSQVR-RCIQVALLCVDMNPRNRP 504 SQ IQ+ C+D +P RP Sbjct: 274 SSQYSLELIQLVHACLDQDPEQRP 297
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 67.4 bits (163), Expect = 3e-11 Identities = 52/160 (32%), Positives = 81/160 (50%), Gaps = 1/160 (0%) Frame = +1 Query: 28 GIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIG 207 GIA G+ YLH +IIHRD+K+ N+L+ + + KISDFG ++ T + G Sbjct: 219 GIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK---MSFAG 272 Query: 208 TYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEG 387 T +M+PE + S K DI+SFGV++ E++TG E+ + + +W G Sbjct: 273 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG---------EIPYKDVDSSAIIWGVG 323 Query: 388 RSTELLDEAMMGSSCDHSQVRRCIQVAL-LCVDMNPRNRP 504 ++ L + SSC ++ L C + PRNRP Sbjct: 324 SNSLHLP---VPSSCPDG-----FKILLRQCWNSKPRNRP 355
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 67.4 bits (163), Expect = 3e-11 Identities = 40/115 (34%), Positives = 63/115 (54%), Gaps = 13/115 (11%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED-------SRLRIIHRDMKASNVLLDRNMIPKISDFGIAR 159 WN I +ARGL YLHED + I HRD+K+ NVLL N+ I+DFG+A Sbjct: 286 WNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLAL 345 Query: 160 MFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F ++ T +GT YM+PE ++G + ++ D+Y+ G+++ E+ + Sbjct: 346 KFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 67.4 bits (163), Expect = 3e-11 Identities = 40/115 (34%), Positives = 63/115 (54%), Gaps = 13/115 (11%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED-------SRLRIIHRDMKASNVLLDRNMIPKISDFGIAR 159 WN I +ARGL YLHED + I HRD+K+ NVLL N+ I+DFG+A Sbjct: 286 WNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLAL 345 Query: 160 MFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F ++ T +GT YM+PE ++G + ++ D+Y+ G+++ E+ + Sbjct: 346 KFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 67.4 bits (163), Expect = 3e-11 Identities = 40/115 (34%), Positives = 63/115 (54%), Gaps = 13/115 (11%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED-------SRLRIIHRDMKASNVLLDRNMIPKISDFGIAR 159 WN I +ARGL YLHED + I HRD+K+ NVLL N+ I+DFG+A Sbjct: 286 WNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLAL 345 Query: 160 MFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F ++ T +GT YM+PE ++G + ++ D+Y+ G+++ E+ + Sbjct: 346 KFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 67.4 bits (163), Expect = 3e-11 Identities = 40/115 (34%), Positives = 63/115 (54%), Gaps = 13/115 (11%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED-------SRLRIIHRDMKASNVLLDRNMIPKISDFGIAR 159 WN I +ARGL YLHED + I HRD+K+ NVLL N+ I+DFG+A Sbjct: 286 WNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLAL 345 Query: 160 MFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F ++ T +GT YM+PE ++G + ++ D+Y+ G+++ E+ + Sbjct: 346 KFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 67.4 bits (163), Expect = 3e-11 Identities = 36/99 (36%), Positives = 59/99 (59%) Frame = +1 Query: 10 RFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAY 189 R + +A+G+ YLH + I+HRD+K+ N+L+D+ K+ DFG++R+ T Sbjct: 651 RLSMAYDVAKGMNYLHNRNP-PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKA--STFLS 707 Query: 190 TLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + GT +M+PE D + KSD+YSFGV++ E+ T Sbjct: 708 SKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELAT 746
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 67.4 bits (163), Expect = 3e-11 Identities = 52/160 (32%), Positives = 81/160 (50%), Gaps = 1/160 (0%) Frame = +1 Query: 28 GIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIG 207 GIA G+ YLH +IIHRD+K+ N+L+ + + KISDFG ++ T + G Sbjct: 252 GIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK---MSFAG 305 Query: 208 TYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEG 387 T +M+PE + S K DI+SFGV++ E++TG E+ + + +W G Sbjct: 306 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG---------EIPYKDVDSSAIIWGVG 356 Query: 388 RSTELLDEAMMGSSCDHSQVRRCIQVAL-LCVDMNPRNRP 504 ++ L + SSC ++ L C + PRNRP Sbjct: 357 SNSLHLP---VPSSCPDG-----FKILLRQCWNRKPRNRP 388
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 67.4 bits (163), Expect = 3e-11 Identities = 52/160 (32%), Positives = 81/160 (50%), Gaps = 1/160 (0%) Frame = +1 Query: 28 GIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIG 207 GIA G+ YLH +IIHRD+K+ N+L+ + + KISDFG ++ T + G Sbjct: 252 GIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK---MSFAG 305 Query: 208 TYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEG 387 T +M+PE + S K DI+SFGV++ E++TG E+ + + +W G Sbjct: 306 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG---------EIPYKDVDSSAIIWGVG 356 Query: 388 RSTELLDEAMMGSSCDHSQVRRCIQVAL-LCVDMNPRNRP 504 ++ L + SSC ++ L C + PRNRP Sbjct: 357 SNSLHLP---VPSSCPDG-----FKILLRQCWNSKPRNRP 388
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 67.4 bits (163), Expect = 3e-11 Identities = 34/97 (35%), Positives = 62/97 (63%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGD-----QTTAYTL 195 +A G+ Y+ R+ IHRD++A+N+L+ + KI+DFG+AR+ D Q + + + Sbjct: 366 VAEGMAYME---RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPI 422 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E++T Sbjct: 423 K------WTAPEAALFGRFTIKSDVWSFGILLTELIT 453
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 67.4 bits (163), Expect = 3e-11 Identities = 39/100 (39%), Positives = 59/100 (59%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +++ A GL +H R+ ++HRD+K N+L+ N I KI+DFGIA+ T T Sbjct: 127 DVMEQAAHGLSVIH---RMDMVHRDIKPGNMLITANGIVKITDFGIAKAAAAVPLTR-TG 182 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 V+GT Y+SPE A + SDIYS GV+ E++ G++ Sbjct: 183 MVVGTAQYVSPEQAQGKEVTAASDIYSLGVVGYEMMAGRR 222
>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8) Length = 979 Score = 67.4 bits (163), Expect = 3e-11 Identities = 44/144 (30%), Positives = 72/144 (50%), Gaps = 1/144 (0%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS 255 I+HRD+K N+ L + + K+ D+G+A+ + + A TL +GT YMSPE ++ Sbjct: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETL--VGTPYYMSPELCQGVKYN 229 Query: 256 MKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLDEAMMGSSCD 435 KSDI++ G ++ E++T K+ +DA LNL + + + D Sbjct: 230 FKSDIWAVGCVIFELLTLKRT---FDATNPLNL-------------CVKIVQGIRAMEVD 273 Query: 436 HSQVR-RCIQVALLCVDMNPRNRP 504 SQ IQ+ C+D +P RP Sbjct: 274 SSQYSLELIQMVHSCLDQDPEQRP 297
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 67.0 bits (162), Expect = 4e-11 Identities = 36/100 (36%), Positives = 60/100 (60%) Frame = +1 Query: 7 TRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA 186 T ++ +A G+ +L IHRD+ A N+L+ N I K++DFG+AR+ D+ TA Sbjct: 336 TLIDMAAQVASGMAFLEAQG---YIHRDLAARNILVGENYICKVADFGLARLIEDDEYTA 392 Query: 187 YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + + +PE A+ F++KSD++SFG+++ EIVT Sbjct: 393 HEGAKF-PIKWTAPEAALYNRFTIKSDVWSFGILMAEIVT 431
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 67.0 bits (162), Expect = 4e-11 Identities = 38/100 (38%), Positives = 60/100 (60%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +++ A GL +H R+ ++HRD+K N+L+ N I KI+DFGIA+ T T Sbjct: 127 DVMEQAAHGLSVIH---RMGLVHRDIKPGNMLITANGILKITDFGIAKAAASVPLTR-TG 182 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 V+GT Y+SPE A + SD+YS GV+ E+++G++ Sbjct: 183 MVVGTAQYVSPEQAQGHQVTPASDVYSLGVVGYEMLSGRR 222
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 67.0 bits (162), Expect = 4e-11 Identities = 40/116 (34%), Positives = 66/116 (56%), Gaps = 4/116 (3%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I ++ GL YL++ R IIHRD+K SN+L++ KI DFG++ G+ + Sbjct: 209 KIAVAVSHGLTYLYDVHR--IIHRDVKPSNILVNGAGQIKICDFGVS----GELINSIAD 262 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK----KNRGFYDAELDLN 351 +GT YMSPE +S+KSD++S GV ++++ G+ +N D++ D N Sbjct: 263 TFVGTSTYMSPERIQGDQYSVKSDVWSLGVSIIDVALGRFPFAENEEDDDSDADNN 318
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 67.0 bits (162), Expect = 4e-11 Identities = 37/92 (40%), Positives = 57/92 (61%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +A G+ YL E R++HRD+ A NVL+D + K++DFG+AR+ D + + I Sbjct: 334 VAEGMSYLEEQ---RVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKI-P 389 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +PE A VFS KSD++SFGV++ E+ T Sbjct: 390 VKWTAPEAANYRVFSQKSDVWSFGVLLHEVFT 421
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 66.6 bits (161), Expect = 5e-11 Identities = 36/106 (33%), Positives = 64/106 (60%), Gaps = 10/106 (9%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT + Sbjct: 100 ILRGIASGMKYL---SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTR 156 Query: 199 -VIGTY---------GYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + GTY + +PE F+ SD++S+G+++ E+++ Sbjct: 157 EITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMS 202
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 66.6 bits (161), Expect = 5e-11 Identities = 35/97 (36%), Positives = 56/97 (57%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 ++ + GL H R ++HRD+K N+L+ + K++DFG+ R T+ T Sbjct: 122 VLRPVLGGLAAAH---RAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITS-TGV 177 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG 309 ++GT Y+SPE DG +SD+YS GV+V E++TG Sbjct: 178 ILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTG 214
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 66.6 bits (161), Expect = 5e-11 Identities = 35/97 (36%), Positives = 56/97 (57%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 ++ + GL H R ++HRD+K N+L+ + K++DFG+ R T+ T Sbjct: 122 VLRPVLGGLAAAH---RAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITS-TGV 177 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG 309 ++GT Y+SPE DG +SD+YS GV+V E++TG Sbjct: 178 ILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTG 214
>AVR2A_RAT (P38444) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 66.6 bits (161), Expect = 5e-11 Identities = 40/115 (34%), Positives = 63/115 (54%), Gaps = 13/115 (11%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED-------SRLRIIHRDMKASNVLLDRNMIPKISDFGIAR 159 WN I +ARGL YLHED + I HRD+K+ NVLL N+ I+DFG+A Sbjct: 286 WNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLAL 345 Query: 160 MFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F ++ T +GT YM+PE ++G + ++ D+Y+ G+++ E+ + Sbjct: 346 KFEAGKSGGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 66.6 bits (161), Expect = 5e-11 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R IHRD++A+NVL+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 350 IAEGMAYIE---RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPI 406 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G F++KSD++SFG+++ EIVT Sbjct: 407 K------WTAPEAINFGCFTIKSDVWSFGILLYEIVT 437
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 66.6 bits (161), Expect = 5e-11 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R IHRD++A+NVL+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 350 IAEGMAYIE---RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPI 406 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G F++KSD++SFG+++ EIVT Sbjct: 407 K------WTAPEAINFGCFTIKSDVWSFGILLYEIVT 437
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 66.6 bits (161), Expect = 5e-11 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ Y+ R IHRD++A+NVL+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 350 IAEGMAYIE---RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPI 406 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G F++KSD++SFG+++ EIVT Sbjct: 407 K------WTAPEAINFGCFTIKSDVWSFGILLYEIVT 437
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 66.6 bits (161), Expect = 5e-11 Identities = 34/92 (36%), Positives = 58/92 (63%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +A G+ Y+ R+ IHRD++A+N+L+ + KI+DFG+AR+ + T K Sbjct: 337 VAEGMAYIE---RMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKF--P 391 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +PE GVF++K+D++SFGV+++ IVT Sbjct: 392 IKWTAPEAIHFGVFTIKADVWSFGVLLMVIVT 423
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 66.2 bits (160), Expect = 6e-11 Identities = 34/99 (34%), Positives = 62/99 (62%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL E + +HRD+ A N+L++RN++ K+SDFG++R+ D AYT Sbjct: 731 MLRGIAAGMQYLSE---MNYVHRDLAARNILVNRNLVCKVSDFGLSRVLEDDPEAAYTTR 787 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++S+G+++ E+++ Sbjct: 788 GGKI--PIRWTAPEAITYRKFTSASDVWSYGIVMWEVIS 824
>AVR2A_XENLA (P27039) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type II) (ACTR-II) Length = 514 Score = 66.2 bits (160), Expect = 6e-11 Identities = 39/115 (33%), Positives = 64/115 (55%), Gaps = 13/115 (11%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED-------SRLRIIHRDMKASNVLLDRNMIPKISDFGIAR 159 WN I +ARGL +LHED + + HRD+K+ NVLL N+ I+DFG+A Sbjct: 287 WNELCLIAETMARGLSHLHEDIPGLKDGHKPAVAHRDIKSKNVLLKNNLTACIADFGLAL 346 Query: 160 MFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F ++ T +GT YM+PE ++G + ++ D+Y+FG+++ E+ + Sbjct: 347 KFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAFGLVLWELAS 400
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 65.9 bits (159), Expect = 8e-11 Identities = 36/98 (36%), Positives = 56/98 (57%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ I +GL YLH + + IHRD+KA+NVLL + K++DFG+A Q T Sbjct: 136 ILREILKGLDYLHSEKK---IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTF- 191 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT +M+PE + K+DI+S G+ +E+ G+ Sbjct: 192 -VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGE 228
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 65.9 bits (159), Expect = 8e-11 Identities = 51/156 (32%), Positives = 80/156 (51%), Gaps = 1/156 (0%) Frame = +1 Query: 43 LLYLHEDSRLRIIHRDMKASNVLLDRN-MIPKISDFGIARMFGGDQTTAYTLKVIGTYGY 219 LL LH I+HRD+K N+LLD++ M+ KI DFGI+++ ++ AYT V+GT Y Sbjct: 113 LLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSS-KSKAYT--VVGTPCY 169 Query: 220 MSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTE 399 +SPE ++ KSDI++ G ++ E+ + K R F A L +L + Sbjct: 170 ISPELCEGKPYNQKSDIWALGCVLYELASLK--RAFEAANLPALVL-------------K 214 Query: 400 LLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPP 507 ++ S +S R Q+ L + + P RPP Sbjct: 215 IMSGTFAPISDRYSPELR--QLVLSLLSLEPAQRPP 248
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 65.9 bits (159), Expect = 8e-11 Identities = 29/75 (38%), Positives = 47/75 (62%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS 255 ++HRD+K +N+ LD N K+ DFG++++ D T +T +GT YMSPE +S Sbjct: 147 VLHRDIKPANIFLDENNSVKLGDFGLSKLL--DNTRVFTQSYVGTPYYMSPEIIRSSPYS 204 Query: 256 MKSDIYSFGVMVLEI 300 KSD+++ G ++ EI Sbjct: 205 AKSDVWALGCVIFEI 219
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 65.9 bits (159), Expect = 8e-11 Identities = 35/93 (37%), Positives = 55/93 (59%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +A+ L H+ IIHRD+K N+L+ + K++DFGIA+ T A+T V+G+ Sbjct: 117 VAKALECAHKSG---IIHRDVKPQNILVTEEGVVKVTDFGIAKSMDSS-TIAHTNSVMGS 172 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG 309 Y SPE A ++D+YS G+++ E+VTG Sbjct: 173 AHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTG 205
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 65.9 bits (159), Expect = 8e-11 Identities = 37/98 (37%), Positives = 59/98 (60%), Gaps = 3/98 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ G+ G+ YL S L +HRD+ A NVL+D N++ K+SDFG++R+ D AYT Sbjct: 740 MLRGVGAGMRYL---SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTT 796 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIV 303 K+ + +PE FS SD++SFGV++ E++ Sbjct: 797 GGKI--PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVL 832
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 65.9 bits (159), Expect = 8e-11 Identities = 51/156 (32%), Positives = 80/156 (51%), Gaps = 1/156 (0%) Frame = +1 Query: 43 LLYLHEDSRLRIIHRDMKASNVLLDRN-MIPKISDFGIARMFGGDQTTAYTLKVIGTYGY 219 LL LH I+HRD+K N+LLD++ M+ KI DFGI+++ ++ AYT V+GT Y Sbjct: 113 LLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSS-KSKAYT--VVGTPCY 169 Query: 220 MSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTE 399 +SPE ++ KSDI++ G ++ E+ + K R F A L +L + Sbjct: 170 ISPELCEGKPYNQKSDIWALGCVLYELASLK--RAFEAANLPALVL-------------K 214 Query: 400 LLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPP 507 ++ S +S R Q+ L + + P RPP Sbjct: 215 IMSGTFAPISDRYSPELR--QLVLSLLSLEPAQRPP 248
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 65.9 bits (159), Expect = 8e-11 Identities = 36/98 (36%), Positives = 56/98 (57%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ I +GL YLH + + IHRD+KA+NVLL + K++DFG+A Q T Sbjct: 124 ILREILKGLDYLHSEKK---IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTF- 179 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT +M+PE + K+DI+S G+ +E+ G+ Sbjct: 180 -VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGE 216
>STK25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 65.9 bits (159), Expect = 8e-11 Identities = 37/98 (37%), Positives = 55/98 (56%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ I +GL YLH + R IHRD+KA+NVLL K++DFG+A Q T Sbjct: 120 ILREILKGLDYLHSE---RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF- 175 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT +M+PE + K+DI+S G+ +E+ G+ Sbjct: 176 -VGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE 212
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 65.5 bits (158), Expect = 1e-10 Identities = 36/106 (33%), Positives = 64/106 (60%), Gaps = 5/106 (4%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N ++ IA G+ ++ E + IHRD++A+N+L+ + KI+DFG+AR+ ++ T Sbjct: 338 NKLLDMAAQIAEGMAFIEEQN---YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYT 394 Query: 184 A-----YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 A + +K + +PE G F++KSD++SFG+++ EIVT Sbjct: 395 AREGAKFPIK------WTAPEAINYGTFTIKSDVWSFGILLTEIVT 434
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 65.5 bits (158), Expect = 1e-10 Identities = 30/101 (29%), Positives = 59/101 (58%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N ++ I+ G+ YL + +++HRD++A N+L+ ++ K++DFG+ + G Sbjct: 317 NQMVHMMAEISEGMAYLESE---KVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGD 373 Query: 184 AYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + Y + +PE A VF+ KSD++S+G+++ EI+T Sbjct: 374 QEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILT 414
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 65.5 bits (158), Expect = 1e-10 Identities = 36/101 (35%), Positives = 61/101 (60%), Gaps = 1/101 (0%) Frame = +1 Query: 7 TRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA 186 T + I+RG+ YLH +IHRD+K++N+LL+ M K++DFG + + +T Sbjct: 188 TVLRLALDISRGMEYLHSQG---VIHRDLKSNNLLLNDEMRVKVADFGTSCL----ETQC 240 Query: 187 YTLKV-IGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K +GTY +M+PE + ++ K D+YSFG+++ E+ T Sbjct: 241 REAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTT 281
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 65.5 bits (158), Expect = 1e-10 Identities = 33/91 (36%), Positives = 52/91 (57%), Gaps = 12/91 (13%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFG------------GDQTTAYTLKVIGTYGY 219 +IHRD+K N+LLD NM KI+DFG A++ D+ A++ +GT Y Sbjct: 219 VIHRDLKPENILLDDNMRTKITDFGSAKILNSSHGSHEEDTHHADKPQAHSRSFVGTARY 278 Query: 220 MSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +SPE D + SDI++FG ++ +++ GK Sbjct: 279 VSPEVLSDKIAGTASDIWAFGCILFQMLAGK 309
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 65.5 bits (158), Expect = 1e-10 Identities = 37/98 (37%), Positives = 55/98 (56%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ I +GL YLH + R IHRD+KA+NVLL K++DFG+A Q T Sbjct: 120 ILREILKGLDYLHSE---RKIHRDIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTF- 175 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT +M+PE + K+DI+S G+ +E+ G+ Sbjct: 176 -VGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE 212
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 65.1 bits (157), Expect = 1e-10 Identities = 54/160 (33%), Positives = 79/160 (49%), Gaps = 3/160 (1%) Frame = +1 Query: 34 ARGLLYLHEDSRLRIIHRDMKASNVLL-DRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 A+ L YLH R I+HRD+K N+LL +++ KI DFG+A ++T GT Sbjct: 116 AKALAYLHSLDR-PIVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKTDMQ-----GT 169 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGR 390 YM+PE ++ K D+YSFG+M+ E++T R + L+ YA + K Sbjct: 170 LRYMAPEAIKHLKYTAKCDVYSFGIMLWELMT----RQLPYSHLENPNSQYA--IMKAIS 223 Query: 391 STELLDEAMMGSSCDH--SQVRRCIQVALLCVDMNPRNRP 504 S E L + S C Q+ C C+D+NP RP Sbjct: 224 SGEKLPMEAVRSDCPEGIKQLMEC------CMDINPEKRP 257
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 65.1 bits (157), Expect = 1e-10 Identities = 38/108 (35%), Positives = 63/108 (58%), Gaps = 3/108 (2%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ RF II A G+ +LH + ++H D+K +N+LLD + KISDFG+A+ G + Sbjct: 115 WDLRFRIIHETAVGMNFLHCMAP-PLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHS 173 Query: 181 TAYTLK-VIGTYGYMSPEYAMD--GVFSMKSDIYSFGVMVLEIVTGKK 315 ++ + GT Y+ PE + +F K D+YSF +++ ++T KK Sbjct: 174 HDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKK 221
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 65.1 bits (157), Expect = 1e-10 Identities = 34/97 (35%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ ++ + + IHRD++A+N+L+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 364 IAEGMAFIEQRN---YIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPI 420 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G F++KSD++SFG++++EIVT Sbjct: 421 K------WTAPEAINFGSFTIKSDVWSFGILLMEIVT 451
>IKKB_DROME (Q9VEZ5) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.1) (DmIKK-beta) (Immune response deficient protein 5) (IKK-like protein) (Lipopolysaccharide-activated kinase) (DLAK) (Cactus kinase IKK) Length = 751 Score = 65.1 bits (157), Expect = 1e-10 Identities = 36/103 (34%), Positives = 60/103 (58%), Gaps = 4/103 (3%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNM----IPKISDFGIARMFGGDQTT 183 +I+ + + L +LH S+ I HRD+K N+++ R + I K++DFG+AR G Sbjct: 162 QILGALRKALHFLH--SQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLAR---GTPDQ 216 Query: 184 AYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 V+GT Y +PE +G ++ D++SFGV+ E+VTG+ Sbjct: 217 TMVQSVVGTRHYYAPEVVENGFYNSTVDLWSFGVIAYELVTGE 259
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 64.7 bits (156), Expect = 2e-10 Identities = 37/99 (37%), Positives = 57/99 (57%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 EIIT I + H IIHRD+K NVL+ + K++DFGIA+ T T Sbjct: 115 EIITEILSAMDMAHSHG---IIHRDLKPQNVLVSSSGTVKVTDFGIAKALSETSLTQ-TN 170 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ Y+SPE A +++SDIY+ G+++ E++TG+ Sbjct: 171 TMFGSVHYLSPEQARGSNATVQSDIYAIGIILFELLTGQ 209
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 64.7 bits (156), Expect = 2e-10 Identities = 34/99 (34%), Positives = 56/99 (56%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I + RGL YLHE ++IHRD+K N+LL+ K+ DFG++ G+ + + Sbjct: 321 KIAESVLRGLSYLHER---KVIHRDIKPQNILLNEKGEIKLCDFGVS----GEAVNSLAM 373 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 GT YM+PE +S+ D++S G+ +LE+ G+ Sbjct: 374 TFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGR 412
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 64.7 bits (156), Expect = 2e-10 Identities = 32/97 (32%), Positives = 62/97 (63%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARM-----FGGDQTTAYTL 195 +A G+ Y+ R+ IHRD++A+N+L+ ++ KI+DFG+AR+ + Q + + Sbjct: 389 VAEGMAYME---RMDYIHRDLRAANILVGERLVCKIADFGLARLIEDNEYNPRQGAKFPI 445 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ G F++KSD++SFG+++ E+++ Sbjct: 446 K------WTAPEAALFGRFTIKSDVWSFGILLTELIS 476
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 64.7 bits (156), Expect = 2e-10 Identities = 35/94 (37%), Positives = 53/94 (56%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I +GL YLH + + IHRD+KA+NVLL K++DFG+A Q T +GT Sbjct: 128 ILKGLDYLHSEKK---IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF--VGT 182 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +M+PE + K+DI+S G+ +E+ G+ Sbjct: 183 PFWMAPEVIQQSAYDSKADIWSLGITAIELAKGE 216
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 64.7 bits (156), Expect = 2e-10 Identities = 35/94 (37%), Positives = 53/94 (56%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I +GL YLH + + IHRD+KA+NVLL K++DFG+A Q T +GT Sbjct: 128 ILKGLDYLHSEKK---IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF--VGT 182 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +M+PE + K+DI+S G+ +E+ G+ Sbjct: 183 PFWMAPEVIQQSAYDSKADIWSLGITAIELAKGE 216
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 64.7 bits (156), Expect = 2e-10 Identities = 36/106 (33%), Positives = 64/106 (60%), Gaps = 5/106 (4%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N ++ IA G+ ++ E + IHRD++A+N+L+ + KI+DFG+AR+ ++ T Sbjct: 338 NKLLDMAAQIAEGMAFIEERN---YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYT 394 Query: 184 A-----YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 A + +K + +PE G F++KSD++SFG+++ EIVT Sbjct: 395 AREGAKFPIK------WTAPEAINYGTFTIKSDVWSFGILLTEIVT 434
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 64.7 bits (156), Expect = 2e-10 Identities = 36/106 (33%), Positives = 64/106 (60%), Gaps = 5/106 (4%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N ++ IA G+ ++ E + IHRD++A+N+L+ + KI+DFG+AR+ ++ T Sbjct: 338 NKLLDMAAQIAEGMAFIEERN---YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYT 394 Query: 184 A-----YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 A + +K + +PE G F++KSD++SFG+++ EIVT Sbjct: 395 AREGAKFPIK------WTAPEAINYGTFTIKSDVWSFGILLTEIVT 434
>NEK6_MOUSE (Q9ES70) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/165 (29%), Positives = 79/165 (47%) Frame = +1 Query: 55 HEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEY 234 H SR R++HRD+K +NV + I K+ D G+ R F + T A++L +GT YMSPE Sbjct: 162 HMHSR-RVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSL--VGTPYYMSPER 218 Query: 235 AMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLDEA 414 + ++ KSDI+S G ++ E+ A L G L+ + E D Sbjct: 219 IHENGYNFKSDIWSLGCLLYEM-----------AALQSPFYGDKMNLFSLCQKIEQCDYP 267 Query: 415 MMGSSCDHSQVRRCIQVALLCVDMNPRNRPPHVFNCHDVGHRECH 549 + ++R + +C+ +P +RP V+ H V R+ H Sbjct: 268 PLPGEHYSEKLRELVS---MCIYPDPDHRPDIVY-VHQVA-RQMH 307
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/111 (37%), Positives = 63/111 (56%), Gaps = 6/111 (5%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIA--RMFGGD 174 W RF I+ IA G+ YLH + ++H D+K N+LLD KI+DFG++ RM Sbjct: 118 WPLRFRILHEIALGVNYLH-NMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLS 176 Query: 175 QTTAY-TLKVIGTYGYMSPEYAMDGV---FSMKSDIYSFGVMVLEIVTGKK 315 Q+ +Y + GT YM PE G S+K DIYS+ V++ E+++ K+ Sbjct: 177 QSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQ 227
>M3K1_RAT (Q62925) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 64.3 bits (155), Expect = 2e-10 Identities = 46/162 (28%), Positives = 78/162 (48%), Gaps = 3/162 (1%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRN-MIPKISDFGIARMFGGDQTTA--YTLKV 201 + RGL YLHE+ +IIHRD+K +N+L+D +I+DFG A T A + ++ Sbjct: 1334 LLRGLSYLHEN---QIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQL 1390 Query: 202 IGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWK 381 +GT +M+PE + D++S G ++E+ K ++AE N L + + Sbjct: 1391 LGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP---WNAEKHSNHLALIFKIAS 1447 Query: 382 EGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPP 507 + + G VAL C+++ P++RPP Sbjct: 1448 ATTAPSIPSHLSPGLR----------DVALRCLELQPQDRPP 1479
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 64.3 bits (155), Expect = 2e-10 Identities = 46/162 (28%), Positives = 78/162 (48%), Gaps = 3/162 (1%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRN-MIPKISDFGIARMFGGDQTTA--YTLKV 201 + RGL YLHE+ +IIHRD+K +N+L+D +I+DFG A T A + ++ Sbjct: 1336 LLRGLSYLHEN---QIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQL 1392 Query: 202 IGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWK 381 +GT +M+PE + D++S G ++E+ K ++AE N L + + Sbjct: 1393 LGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP---WNAEKHSNHLALIFKIAS 1449 Query: 382 EGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPP 507 + + G VAL C+++ P++RPP Sbjct: 1450 ATTAPSIPSHLSPGLR----------DVALRCLELQPQDRPP 1481
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/102 (38%), Positives = 60/102 (58%), Gaps = 2/102 (1%) Frame = +1 Query: 7 TRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA 186 T ++ IA G+ YL + IHRD+ A NVL+ I KI+DFG+AR+ D+ Sbjct: 346 TLIDMAAQIAAGMAYLESQN---YIHRDLAARNVLVGDGNIVKIADFGLARLIKEDE--- 399 Query: 187 YTLKVIGTY--GYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 Y +V + + +PE A FS+KSD++SFG+++ E+VT Sbjct: 400 YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVT 441
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 64.3 bits (155), Expect = 2e-10 Identities = 51/161 (31%), Positives = 77/161 (47%), Gaps = 3/161 (1%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +A G+ YL + IHRD+ A N+L+ N I K++DFG+AR+ D A T Sbjct: 198 VAAGMAYLELHN---YIHRDLAARNILVGDNNICKVADFGLARLIVSDDYNA-TEGAKFP 253 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK--NRGFYDAELDLNL-LGYAWTLWK 381 + +PE A+ FS+KSD++SFG+++ E+VT + G +AE+ NL GY Sbjct: 254 IKWTAPEAALFNRFSIKSDVWSFGILITELVTYGRIPYPGMSNAEVLQNLDKGYR----- 308 Query: 382 EGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 C + Q+ L C NP +RP Sbjct: 309 --------------MPCPVTTPESLYQIMLDCWKRNPADRP 335
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/94 (39%), Positives = 58/94 (61%), Gaps = 2/94 (2%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK--VI 204 +A G+ YL +SR IHRD+ A NVL+ + I K++DFG+AR+F D Y + + Sbjct: 338 VASGMAYL--ESR-NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394 Query: 205 GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +PE FS+KSD++SFG+++ EI+T Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIIT 428
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 63.9 bits (154), Expect = 3e-10 Identities = 36/106 (33%), Positives = 63/106 (59%), Gaps = 5/106 (4%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N ++ I G+ +L E + IHRD++A+N+L+ + KI+DFG+AR+ ++ T Sbjct: 338 NKLLDMAAQIVEGMAFLEERN---YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYT 394 Query: 184 A-----YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 A + +K + +PE G F++KSD++SFG+++ EIVT Sbjct: 395 AREGAKFPIK------WTAPEAINYGTFTIKSDVWSFGILMTEIVT 434
>NEK6_RAT (P59895) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 63.9 bits (154), Expect = 3e-10 Identities = 44/150 (29%), Positives = 72/150 (48%) Frame = +1 Query: 55 HEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEY 234 H SR R++HRD+K +NV + I K+ D G+ R F + T A++L +GT YMSPE Sbjct: 162 HMHSR-RVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSL--VGTPYYMSPER 218 Query: 235 AMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLDEA 414 + ++ KSDI+S G ++ E+ A L G L+ + E D Sbjct: 219 IHENGYNFKSDIWSLGCLLYEM-----------AALQSPFYGDKMNLFSLCQKIEQCDYP 267 Query: 415 MMGSSCDHSQVRRCIQVALLCVDMNPRNRP 504 + ++R + +C+ +P +RP Sbjct: 268 PLPGEHYSEKLRELVS---MCIYPDPNHRP 294
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 63.9 bits (154), Expect = 3e-10 Identities = 33/97 (34%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 I+ G+ ++ + + IHRD++A+N+L+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 362 ISEGMAFIEQRN---YIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPI 418 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G F++KSD++SFG++++EIVT Sbjct: 419 K------WTAPEAINFGSFTIKSDVWSFGILLMEIVT 449
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/102 (39%), Positives = 62/102 (60%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH++ + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 126 ILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 182 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+DI+SFG+ +E+ TG Sbjct: 183 RKTFVGTPCWMAPE-VMEQVRGYDFKADIWSFGITAIELATG 223
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/106 (36%), Positives = 61/106 (57%), Gaps = 7/106 (6%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIA----RMFGGDQTT 183 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A R G Q Sbjct: 438 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVE 494 Query: 184 AYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 T G+ +M+PE + FS +SD+YS+G+++ E++TG+ Sbjct: 495 QLT----GSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE 536
>AVR2B_XENLA (P27041) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 511 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/116 (34%), Positives = 62/116 (53%), Gaps = 14/116 (12%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED--------SRLRIIHRDMKASNVLLDRNMIPKISDFGIA 156 WN I +ARGL YLHED + I HRD K+ NVLL ++ ++DFG+A Sbjct: 283 WNELCHITETMARGLAYLHEDVPRCKGEGHKPAIAHRDFKSKNVLLRNDLTAILADFGLA 342 Query: 157 RMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F + T +GT YM+PE ++G + ++ D+Y+ G+++ EIV+ Sbjct: 343 VRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDSFLRIDMYAMGLVLWEIVS 397
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 63.9 bits (154), Expect = 3e-10 Identities = 33/97 (34%), Positives = 64/97 (65%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 I+ G+ ++ + + IHRD++A+N+L+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 341 ISEGMAFIEQRN---YIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPI 397 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G F++KSD++SFG++++EIVT Sbjct: 398 K------WTAPEAINFGSFTIKSDVWSFGILLMEIVT 428
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/102 (39%), Positives = 62/102 (60%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH++ + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 126 ILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 182 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+DI+SFG+ +E+ TG Sbjct: 183 RKTFVGTPCWMAPE-VMEQVRGYDFKADIWSFGITAIELATG 223
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/102 (39%), Positives = 62/102 (60%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH++ + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 126 ILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 182 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+DI+SFG+ +E+ TG Sbjct: 183 RKTFVGTPCWMAPE-VMEQVRGYDFKADIWSFGITAIELATG 223
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/102 (39%), Positives = 62/102 (60%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH++ + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 126 ILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 182 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+DI+SFG+ +E+ TG Sbjct: 183 RKTFVGTPCWMAPE-VMEQVRGYDFKADIWSFGITAIELATG 223
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 63.9 bits (154), Expect = 3e-10 Identities = 35/92 (38%), Positives = 57/92 (61%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +A G+ YL E R++HRD+ A NVL+ ++ K++DFG+AR+ D + + I Sbjct: 338 VAEGMSYLEER---RVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKI-P 393 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +PE A VFS KSD++SFG+++ E+ T Sbjct: 394 VKWTAPEAANYRVFSQKSDVWSFGILLYEVFT 425
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 63.5 bits (153), Expect = 4e-10 Identities = 40/118 (33%), Positives = 64/118 (54%), Gaps = 5/118 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLD---RNMIPKISDFGIARMFGGDQTTAY 189 ++ +A GL +H+ IIHRD+K NV + R ++ DFGIAR+ D ++ Sbjct: 115 LLQQLAEGLAAIHDKG---IIHRDLKPENVFISKSARGEQARLLDFGIARLVEPDAASSV 171 Query: 190 TL--KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLL 357 + V+GT Y+SPE A+ +SD+YSFGV+ +++G+ +D L N L Sbjct: 172 SQIGVVLGTPEYLSPEQAVGAKVDTRSDLYSFGVLTYRVLSGRLP---FDGPLPRNFL 226
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 63.5 bits (153), Expect = 4e-10 Identities = 34/99 (34%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 727 MLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 783 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + SPE F+ SD++S+G+++ E+++ Sbjct: 784 GGKI--PVRWTSPEATAYRKFTSASDVWSYGIVLWEVMS 820
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 63.5 bits (153), Expect = 4e-10 Identities = 38/112 (33%), Positives = 63/112 (56%), Gaps = 13/112 (11%) Frame = +1 Query: 10 RFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPK-------------ISDFG 150 R ++ IA+G+ YLH + I+HRD+ + N+LLD N+ PK ISDFG Sbjct: 1392 RLKLALDIAKGMNYLHGWTP-PILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFG 1450 Query: 151 IARMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 ++R+ + + + +G YM+PE S KSD+YS+G+++ E++T Sbjct: 1451 LSRL--KKEQASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLT 1500
>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)| (NimA-related protein kinase 8) Length = 697 Score = 63.5 bits (153), Expect = 4e-10 Identities = 38/100 (38%), Positives = 62/100 (62%), Gaps = 1/100 (1%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRN-MIPKISDFGIARMFGGDQTTAYTL 195 I+ + LL L+ I+HRD+K N+LLD++ MI KI DFGI+++ ++ AYT Sbjct: 105 ILHSFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVS-KSKAYT- 162 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 V+GT Y+SPE ++ KSDI++ G ++ E+ + K+ Sbjct: 163 -VVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKR 201
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 63.5 bits (153), Expect = 4e-10 Identities = 41/124 (33%), Positives = 67/124 (54%), Gaps = 5/124 (4%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRN-----MIPKISDFGIARMFGGDQT 180 ++ I++G +YL R+ IHRD+ A N L+ I KI DFG+AR + Sbjct: 2058 DLCVDISKGCVYLE---RMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDY 2114 Query: 181 TAYTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLG 360 + + +M+PE MDG+F+ +SD++SFG+++ EI+T Y A +L++L Sbjct: 2115 YRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILT--LGHQPYPAHSNLDVLN 2172 Query: 361 YAWT 372 Y T Sbjct: 2173 YVQT 2176
>PKN1_CORGL (Q8NU98) Probable serine/threonine protein kinase pknB (EC| 2.7.11.1) Length = 646 Score = 63.5 bits (153), Expect = 4e-10 Identities = 37/81 (45%), Positives = 50/81 (61%), Gaps = 2/81 (2%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK--VIGTYGYMSPEYAMDGV 249 IIHRD+K +N+++ K+ DFGIAR D T+A T VIGT Y+SPE A Sbjct: 132 IIHRDVKPANIMITNTGGVKVMDFGIARAVN-DSTSAMTQTSAVIGTAQYLSPEQARGKP 190 Query: 250 FSMKSDIYSFGVMVLEIVTGK 312 +SDIY+ G ++ E+VTGK Sbjct: 191 ADARSDIYATGCVMYELVTGK 211
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 63.5 bits (153), Expect = 4e-10 Identities = 35/97 (36%), Positives = 60/97 (61%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ +A G+ YL + + IHRD+ A N+L+ + I K++DFG+AR+ + A+T Sbjct: 338 DVAAQVASGMSYLEQQN---YIHRDLAARNILVGEHGICKVADFGLARVIDEEIYEAHTG 394 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 + +PE AM F++KSD++SFGV++ EI+T Sbjct: 395 AKF-PIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIIT 430
>HIPPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC 2.7.11.1)| Length = 669 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/102 (38%), Positives = 58/102 (56%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I++ +GL+YLH R IHRD+KA+N+LL+ K++DFG+A T A Sbjct: 141 ILSDTLQGLVYLH---LRRKIHRDIKAANILLNTEGYAKLADFGVAGQL--TDTMAKRNT 195 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRG 324 VIGT +M+PE + + +DI+S G+ LE+ GK G Sbjct: 196 VIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYG 237
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 63.2 bits (152), Expect = 5e-10 Identities = 34/99 (34%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 726 MLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 782 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + SPE F+ SD++S+G+++ E+++ Sbjct: 783 GGKI--PIRWTSPEAMSYRKFTSASDVWSYGIVLWEVMS 819
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 63.2 bits (152), Expect = 5e-10 Identities = 34/99 (34%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 726 MLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 782 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + SPE F+ SD++S+G+++ E+++ Sbjct: 783 GGKI--PIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMS 819
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 63.2 bits (152), Expect = 5e-10 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGD-----QTTAYTL 195 IA G+ YL S IHRD+ A N+L+ + K++DFG+AR+ D + T + + Sbjct: 170 IASGMTYLEAHS---YIHRDLAARNILVGEGNVCKVADFGLARVIKEDIYNPREGTKFPI 226 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE A+ F++KSD++SFGV++ EIVT Sbjct: 227 K------WTAPEAALYNRFTIKSDVWSFGVLISEIVT 257
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 63.2 bits (152), Expect = 5e-10 Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 3/162 (1%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRN-MIPKISDFGIARMFGGDQTTA--YTLKV 201 + RGL YLHE+ +IIHRD+K +N+L+D +I+DFG A T A + ++ Sbjct: 1334 LLRGLSYLHEN---QIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQL 1390 Query: 202 IGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWK 381 +GT +M+PE + D++S G ++E+ K ++AE N L + + Sbjct: 1391 LGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP---WNAEKHSNHLALIFKIAS 1447 Query: 382 EGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPRNRPP 507 + + G VA+ C+++ P++RPP Sbjct: 1448 ATTAPSIPSHLSPGLR----------DVAVRCLELQPQDRPP 1479
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 63.2 bits (152), Expect = 5e-10 Identities = 33/99 (33%), Positives = 60/99 (60%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL + + +HRD+ A N+L++ N++ K+SDFG++R+ D YT Sbjct: 719 MLRGIAAGMKYL---ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS 775 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++SFG+++ E++T Sbjct: 776 GGKI--PIRWTAPEAISYRKFTSASDVWSFGIVMWEVMT 812
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 63.2 bits (152), Expect = 5e-10 Identities = 34/99 (34%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 782 MLRGIAAGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 838 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++S+G+++ E+V+ Sbjct: 839 GGKI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS 875
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/106 (33%), Positives = 63/106 (59%), Gaps = 5/106 (4%) Frame = +1 Query: 4 NTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTT 183 N ++ IA G+ ++ + IHRD++A+N+L+ + KI+DFG+AR+ ++ T Sbjct: 337 NKLLDMAAQIAEGMAFIEAKN---YIHRDLRAANILVSEALCCKIADFGLARLIEDNEYT 393 Query: 184 A-----YTLKVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 A + +K + +PE G F++KSD++SFG+++ EIVT Sbjct: 394 AREGAKFPIK------WTAPEAINYGTFTIKSDVWSFGILLTEIVT 433
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 3/102 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A + + Sbjct: 447 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 503 Query: 196 KVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ +M+PE + FS +SD+YS+G+++ E++TG+ Sbjct: 504 QPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE 545
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 3/102 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A + + Sbjct: 447 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 503 Query: 196 KVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ +M+PE D FS +SD+YS+G+++ E++ G+ Sbjct: 504 QPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGE 545
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 3/102 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A + + Sbjct: 447 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 503 Query: 196 KVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ +M+PE + FS +SD+YS+G+++ E++TG+ Sbjct: 504 QPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE 545
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 63.2 bits (152), Expect = 5e-10 Identities = 48/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R IA G+ YLH + IIHRD+ + N L+ N ++DFG+AR+ ++T Sbjct: 434 WSQRVSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKT 490 Query: 181 TAYTLK------------VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNR- 321 L+ V+G +M+PE + K D++SFG+++ EI+ G+ N Sbjct: 491 QPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549 Query: 322 -GFYDAELD--LNLLGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNP 492 + +D LN+ G+ + C + + + C D++P Sbjct: 550 PDYLPRTMDFGLNVRGF------------------LDRYCPPNCPPSFFPITVRCCDLDP 591 Query: 493 RNRPPHV 513 RP V Sbjct: 592 EKRPSFV 598
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 63.2 bits (152), Expect = 5e-10 Identities = 34/99 (34%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 619 MLRGIAAGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 675 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++S+G+++ E+V+ Sbjct: 676 GGKI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS 712
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 3/102 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A + + Sbjct: 122 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 178 Query: 196 KVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ +M+PE D FS +SD+YS+G+++ E++ G+ Sbjct: 179 QPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGE 220
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 63.2 bits (152), Expect = 5e-10 Identities = 33/99 (33%), Positives = 59/99 (59%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + RGL+YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 169 KVSIAVLRGLVYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 222 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SD++S G+ ++E+ G+ Sbjct: 223 SFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGR 261
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 2/81 (2%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYT--LKVIGTYGYMSPEYAMDGV 249 IIHRD+K +N++++ K+ DFGIAR D T+A T VIGT Y+SPE A Sbjct: 132 IIHRDVKPANIMINNTGGVKVMDFGIARALD-DSTSAMTQTAAVIGTAQYLSPEQARGKP 190 Query: 250 FSMKSDIYSFGVMVLEIVTGK 312 +SD+Y+ G ++ E+VTG+ Sbjct: 191 ADARSDVYAAGCVLYELVTGR 211
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/99 (35%), Positives = 56/99 (56%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I G+ GL YLH+ +IIHRD+K SN+LL K+ DFG++ G+ + Sbjct: 185 KIAFGVLSGLSYLHDR---KIIHRDIKPSNILLTSKGQVKLCDFGVS----GELVNSLAG 237 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 GT YM+PE G +++ SDI+S G+ ++E+ + Sbjct: 238 TFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNR 276
>NEK6_HUMAN (Q9HC98) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) (Protein kinase SID6-1512) Length = 313 Score = 63.2 bits (152), Expect = 5e-10 Identities = 32/82 (39%), Positives = 51/82 (62%) Frame = +1 Query: 55 HEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEY 234 H SR R++HRD+K +NV + + K+ D G+ R F + T A++L +GT YMSPE Sbjct: 162 HMHSR-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSL--VGTPYYMSPER 218 Query: 235 AMDGVFSMKSDIYSFGVMVLEI 300 + ++ KSDI+S G ++ E+ Sbjct: 219 IHENGYNFKSDIWSLGCLLYEM 240
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 62.8 bits (151), Expect = 7e-10 Identities = 38/111 (34%), Positives = 66/111 (59%), Gaps = 9/111 (8%) Frame = +1 Query: 7 TRFEIITGI------ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG 168 T+FE+I I A+G+ YLH S IIHRD+K++N+ L ++ KI DFG+A + Sbjct: 108 TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS 164 Query: 169 GDQTTAYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + ++ G+ +M+PE +S +SD+Y+FG+++ E++TG+ Sbjct: 165 RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 215
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 62.8 bits (151), Expect = 7e-10 Identities = 35/111 (31%), Positives = 62/111 (55%), Gaps = 6/111 (5%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQ- 177 W ++ + G+ YLH ++HRD+K SN+LLD + K++DFG++ GG Q Sbjct: 115 WPLLCRLLQEVVLGMCYLHSLDP-PLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQS 173 Query: 178 ---TTAYTLKVIGTYGYMSPE--YAMDGVFSMKSDIYSFGVMVLEIVTGKK 315 + + + GT Y+ PE + ++ S SD+YSFG++V ++ G++ Sbjct: 174 GSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 62.8 bits (151), Expect = 7e-10 Identities = 39/102 (38%), Positives = 61/102 (59%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH + + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 184 ILKEVLEGLDYLHRNGQ---IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV 240 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+D++SFG+ +E+ TG Sbjct: 241 RKTFVGTPCWMAPE-VMEQVRGYDFKADMWSFGITAIELATG 281
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 62.8 bits (151), Expect = 7e-10 Identities = 38/111 (34%), Positives = 66/111 (59%), Gaps = 9/111 (8%) Frame = +1 Query: 7 TRFEIITGI------ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG 168 T+FE+I I A+G+ YLH S IIHRD+K++N+ L ++ KI DFG+A + Sbjct: 156 TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS 212 Query: 169 GDQTTAYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + ++ G+ +M+PE +S +SD+Y+FG+++ E++TG+ Sbjct: 213 RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 263
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 62.8 bits (151), Expect = 7e-10 Identities = 34/99 (34%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + RGL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 172 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 225 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 226 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGR 264
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 62.8 bits (151), Expect = 7e-10 Identities = 36/92 (39%), Positives = 53/92 (57%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +ARG+ YL + IHRD+ A NVL+ N + KI+DFG+AR T Sbjct: 612 LARGMEYLASQ---KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 668 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 +M+PE D V++ +SD++SFGV++ EI T Sbjct: 669 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 700
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 62.8 bits (151), Expect = 7e-10 Identities = 38/111 (34%), Positives = 66/111 (59%), Gaps = 9/111 (8%) Frame = +1 Query: 7 TRFEIITGI------ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG 168 T+FE+I I A+G+ YLH S IIHRD+K++N+ L ++ KI DFG+A + Sbjct: 586 TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS 642 Query: 169 GDQTTAYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + ++ G+ +M+PE +S +SD+Y+FG+++ E++TG+ Sbjct: 643 RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 693
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 62.8 bits (151), Expect = 7e-10 Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 3/102 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A + + Sbjct: 447 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 503 Query: 196 KVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ +M+PE FS +SD+YS+G+++ E++TG+ Sbjct: 504 QPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGE 545
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 62.8 bits (151), Expect = 7e-10 Identities = 36/92 (39%), Positives = 53/92 (57%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +ARG+ YL + IHRD+ A NVL+ N + KI+DFG+AR T Sbjct: 610 LARGMEYLASQ---KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 666 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 +M+PE D V++ +SD++SFGV++ EI T Sbjct: 667 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 62.8 bits (151), Expect = 7e-10 Identities = 36/92 (39%), Positives = 53/92 (57%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +ARG+ YL + IHRD+ A NVL+ N + KI+DFG+AR T Sbjct: 610 LARGMEYLASQ---KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 666 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 +M+PE D V++ +SD++SFGV++ EI T Sbjct: 667 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 62.8 bits (151), Expect = 7e-10 Identities = 38/111 (34%), Positives = 66/111 (59%), Gaps = 9/111 (8%) Frame = +1 Query: 7 TRFEIITGI------ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG 168 T+FE+I I A+G+ YLH S IIHRD+K++N+ L ++ KI DFG+A + Sbjct: 586 TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS 642 Query: 169 GDQTTAYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + ++ G+ +M+PE +S +SD+Y+FG+++ E++TG+ Sbjct: 643 RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 693
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 62.8 bits (151), Expect = 7e-10 Identities = 38/111 (34%), Positives = 66/111 (59%), Gaps = 9/111 (8%) Frame = +1 Query: 7 TRFEIITGI------ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG 168 T+FE+I I A+G+ YLH S IIHRD+K++N+ L ++ KI DFG+A + Sbjct: 172 TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS 228 Query: 169 GDQTTAYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + ++ G+ +M+PE +S +SD+Y+FG+++ E++TG+ Sbjct: 229 RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 279
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 62.8 bits (151), Expect = 7e-10 Identities = 40/98 (40%), Positives = 58/98 (59%), Gaps = 4/98 (4%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF---GGDQTTAYTLKV 201 I +G+ YLHE+ ++HRD+K +NV+L I K+ DFG AR G + T + LK Sbjct: 1170 ILQGVAYLHENC---VVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKS 1226 Query: 202 I-GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GT +M+PE + + KSDI+S G V E+ TGK Sbjct: 1227 MHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGK 1264
>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase) Length = 944 Score = 62.8 bits (151), Expect = 7e-10 Identities = 43/144 (29%), Positives = 71/144 (49%), Gaps = 1/144 (0%) Frame = +1 Query: 76 IIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS 255 I+HRD+K N+ L + + K+ D+G+A+ + + A T +GT YMSPE +S Sbjct: 154 ILHRDIKTLNIFLTKANLIKLGDYGLAKQLSSEYSMAETC--VGTLYYMSPEICQGVKYS 211 Query: 256 MKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNL-LGYAWTLWKEGRSTELLDEAMMGSSC 432 KSDI++ G ++ E++T + +DA LNL + W G LD + Sbjct: 212 FKSDIWAVGCVLYELLTLTRT---FDATNPLNLCVKIVQGNWAVG-----LDNTV----- 258 Query: 433 DHSQVRRCIQVALLCVDMNPRNRP 504 + I+V C++ +P RP Sbjct: 259 ---YTQELIEVVHACLEQDPEKRP 279
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 62.8 bits (151), Expect = 7e-10 Identities = 39/102 (38%), Positives = 61/102 (59%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH + + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 174 ILKEVLEGLDYLHRNGQ---IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV 230 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+D++SFG+ +E+ TG Sbjct: 231 RKTFVGTPCWMAPE-VMEQVRGYDFKADMWSFGITAIELATG 271
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 62.8 bits (151), Expect = 7e-10 Identities = 38/111 (34%), Positives = 66/111 (59%), Gaps = 9/111 (8%) Frame = +1 Query: 7 TRFEIITGI------ARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFG 168 T+FE+I I A+G+ YLH S IIHRD+K++N+ L ++ KI DFG+A + Sbjct: 546 TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS 602 Query: 169 GDQTTAYTLKVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + ++ G+ +M+PE +S +SD+Y+FG+++ E++TG+ Sbjct: 603 RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 653
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 62.8 bits (151), Expect = 7e-10 Identities = 35/90 (38%), Positives = 54/90 (60%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 +A G+ YL + IHRD+ A NVL+ N + K+ DFG+AR+ D ++ V Sbjct: 296 VAEGMCYLESQN---YIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNV--P 350 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEI 300 Y + +PE G +S+KSD++SFGV++ EI Sbjct: 351 YKWTAPEALSRGHYSIKSDVWSFGVLLHEI 380
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 62.8 bits (151), Expect = 7e-10 Identities = 39/102 (38%), Positives = 61/102 (59%), Gaps = 5/102 (4%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMF--GGDQTTAYT 192 I+ + GL YLH + + IHRD+KA N+LL + +I+DFG++ GGD T Sbjct: 181 ILKEVLEGLDYLHRNGQ---IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV 237 Query: 193 LKV-IGTYGYMSPEYAMDGV--FSMKSDIYSFGVMVLEIVTG 309 K +GT +M+PE M+ V + K+D++SFG+ +E+ TG Sbjct: 238 RKTFVGTPCWMAPE-VMEQVRGYDFKADMWSFGITAIELATG 278
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 62.8 bits (151), Expect = 7e-10 Identities = 34/99 (34%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 777 MLRGIASGMKYL---SDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTT 833 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE FS SD++S+G+++ E+++ Sbjct: 834 GGKI--PIRWTAPEAIAYRKFSSASDVWSYGIVMWEVMS 870
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 62.8 bits (151), Expect = 7e-10 Identities = 37/98 (37%), Positives = 57/98 (58%), Gaps = 3/98 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ G+ G+ YL S L IHRD+ A NVL+D ++ K+SDFG++R D AYT Sbjct: 739 MLRGVGAGMRYL---SDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTA 795 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIV 303 K+ + +PE FS SD++SFGV++ E++ Sbjct: 796 GGKI--PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVL 831
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 62.8 bits (151), Expect = 7e-10 Identities = 37/92 (40%), Positives = 53/92 (57%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 IARG+ YL + IHRD+ A NVL+ N + KI+DFG+AR T Sbjct: 600 IARGMEYLASQ---KCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLP 656 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 +M+PE D V++ +SD++SFGV++ EI T Sbjct: 657 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 688
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 62.8 bits (151), Expect = 7e-10 Identities = 34/99 (34%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + RGL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 172 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 225 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 226 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGR 264
>DAF4_CAEEL (P50488) Cell-surface receptor daf-4 precursor (EC 2.7.11.30)| (Abnormal dauer formation protein 4) Length = 744 Score = 62.4 bits (150), Expect = 9e-10 Identities = 38/112 (33%), Positives = 62/112 (55%), Gaps = 13/112 (11%) Frame = +1 Query: 19 IITGIARGLLYLHEDS-------RLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQ 177 II + GL +LH+D + IIHRD+K+ N+L+ +M I+DFG+AR++ D Sbjct: 410 IIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDI 469 Query: 178 TTAYTLKVIGTYGYMSPEYAMDGVFSM------KSDIYSFGVMVLEIVTGKK 315 + L +GT YMSPE ++G D+YS G+++ E+++ K Sbjct: 470 EQSDLLGQVGTKRYMSPE-MLEGATEFTPTAFKAMDVYSMGLVMWEVISRTK 520
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 62.4 bits (150), Expect = 9e-10 Identities = 37/98 (37%), Positives = 55/98 (56%), Gaps = 1/98 (1%) Frame = +1 Query: 22 ITG-IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 +TG + L YLH + RI+HRD+K NVLLD+NM K+ DFG+AR T Sbjct: 105 VTGHLVSALYYLHSN---RILHRDLKPQNVLLDKNMHAKLCDFGLARNM--TLGTHVLTS 159 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 + GT YM+PE + + +D++S G + E + G+ Sbjct: 160 IKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQ 197
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 62.4 bits (150), Expect = 9e-10 Identities = 36/98 (36%), Positives = 57/98 (58%), Gaps = 3/98 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ G+ G+ YL S L IHRD+ A N+L+D ++ K+SDFG++R D AYT Sbjct: 107 MLKGVGAGMRYL---SDLGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTA 163 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIV 303 K+ + +PE FS SD++SFGV++ E++ Sbjct: 164 GGKI--PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVL 199
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 62.4 bits (150), Expect = 9e-10 Identities = 31/83 (37%), Positives = 49/83 (59%) Frame = +1 Query: 67 RLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPEYAMDG 246 R +HRDMK NVL+ + K++DFG+ R D T T V+GT Y++PE G Sbjct: 134 RAGFVHRDMKPENVLIGDDGRVKVADFGLVRAV--DSVTNTTGTVLGTVSYLAPEQIEHG 191 Query: 247 VFSMKSDIYSFGVMVLEIVTGKK 315 + D+Y+ G+++ E++TG+K Sbjct: 192 TADPRVDVYACGILLYEMLTGEK 214
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/93 (35%), Positives = 51/93 (54%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I L YLH IIHRD+K N+LL+ +M +I+DFG A++ D A +GT Sbjct: 192 IVSALEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPDSKQARANSFVGT 248 Query: 211 YGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTG 309 Y+SPE + SD+++ G ++ ++V G Sbjct: 249 AQYVSPELLTEKSACKSSDLWALGCIIYQLVAG 281
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/98 (37%), Positives = 56/98 (57%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ +GL YLH +R IHRD+KA N+LL+ K++DFG+A T A Sbjct: 129 ILQSTLKGLEYLHF---MRKIHRDIKAGNILLNTEGHAKLADFGVAGQL--TDTMAKRNT 183 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 VIGT +M+PE + ++ +DI+S G+ +E+ GK Sbjct: 184 VIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK 221
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +GL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 168 KVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 221 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +GL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 167 KVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 220 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +GL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 167 KVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 220 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +GL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 167 KVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 220 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +GL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 167 KVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 220 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + RGL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 172 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 225 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YM+PE +S++SDI+S G+ ++E+ G+ Sbjct: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGR 264
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 62.0 bits (149), Expect = 1e-09 Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R IA G+ YLH + IIHRD+ + N L+ N ++DFG+AR+ ++ Sbjct: 434 WSQRVSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKN 490 Query: 181 TAYTLK------------VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNR- 321 + L+ V+G +M+PE + K D++SFG+++ EI+ G+ N Sbjct: 491 QSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549 Query: 322 -GFYDAELD--LNLLGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNP 492 + +D LN+ G+ + C + + + C D++P Sbjct: 550 PDYLPRTMDFGLNVRGF------------------LDRYCPPNCPPSFFPITVRCCDLDP 591 Query: 493 RNRPPHV 513 RP V Sbjct: 592 EKRPSFV 598
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 62.0 bits (149), Expect = 1e-09 Identities = 34/91 (37%), Positives = 53/91 (58%) Frame = +1 Query: 40 GLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGY 219 GL YLH + I+HRD+K +N+L+D K++DFG ++ T + + GT + Sbjct: 183 GLEYLHNHA---IMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYW 239 Query: 220 MSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 M+PE + S +DI+S G V+E+VTGK Sbjct: 240 MAPEVILQTGHSFSADIWSVGCTVIEMVTGK 270
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/94 (35%), Positives = 55/94 (58%) Frame = +1 Query: 25 TGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVI 204 T IA+G+ YL E R++HRD+ A NVL+ + KI+DFG+A++ D Sbjct: 1045 TQIAKGMSYLEEK---RLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK 1101 Query: 205 GTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 +++ E + VF+ KSD+++FGV + E++T Sbjct: 1102 MPIKWLALECIRNRVFTSKSDVWAFGVTIWELLT 1135
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 2/98 (2%) Frame = +1 Query: 25 TGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVI 204 T I + Y+H R+IHRD+K N+ D N KI DFG+A + + YT + Sbjct: 186 TQICGAIKYMHSR---RVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYT--IC 240 Query: 205 GTYGYMSPEYAM--DGVFSMKSDIYSFGVMVLEIVTGK 312 GT Y++PE M S + DI+S GVM+ ++ GK Sbjct: 241 GTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGK 278
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 3/102 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 +I A+G+ YLH + IIHRDMK++N+ L + KI DFG+A + + Sbjct: 180 DIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVE 236 Query: 196 KVIGTYGYMSPEYAM---DGVFSMKSDIYSFGVMVLEIVTGK 312 + G+ +M+PE FS +SD+YS+G+++ E++TG+ Sbjct: 237 QPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGE 278
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 62.0 bits (149), Expect = 1e-09 Identities = 34/99 (34%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + RGL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 170 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 223 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 224 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGR 262
>KIC1_YEAST (P38692) Serine/threonine-protein kinase KIC1 (EC 2.7.11.1) (Kinase| that interacts with CDC31) (N-rich kinase 1) Length = 1080 Score = 62.0 bits (149), Expect = 1e-09 Identities = 47/151 (31%), Positives = 75/151 (49%), Gaps = 1/151 (0%) Frame = +1 Query: 52 LHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGYMSPE 231 +H+D+ +IHRD+KA+NVL+ K+ DFG+A +QT+ + GT +M+PE Sbjct: 135 IHKDN---VIHRDIKAANVLITNEGNVKLCDFGVAAQV--NQTSLRRQTMAGTPYWMAPE 189 Query: 232 YAMDGV-FSMKSDIYSFGVMVLEIVTGKKNRGFYDAELDLNLLGYAWTLWKEGRSTELLD 408 M+GV + K DI+S G+ EI TG N + D E R+ +L+ Sbjct: 190 VIMEGVYYDTKVDIWSLGITTYEIATG--NPPYCDVE--------------ALRAMQLII 233 Query: 409 EAMMGSSCDHSQVRRCIQVALLCVDMNPRNR 501 ++ D S + LC+D +P+ R Sbjct: 234 KSKPPRLEDRSYSTSLKEFIALCLDEDPKER 264
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GI+ G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 780 MLRGISAGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 836 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++S+G+++ E+V+ Sbjct: 837 GGKI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS 873
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 62.0 bits (149), Expect = 1e-09 Identities = 32/99 (32%), Positives = 60/99 (60%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL + + +HRD+ A N+L++ N++ K+SDFG++R+ D YT Sbjct: 720 MLRGIASGMKYL---ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS 776 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++S+G+++ E++T Sbjct: 777 GGKI--PIRWTAPEAISYRKFTSASDVWSYGIVMWEVMT 813
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/97 (34%), Positives = 63/97 (64%), Gaps = 5/97 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTA-----YTL 195 IA G+ ++ + + IHRD++A+N+L+ +++ KI+DFG+AR+ ++ TA + + Sbjct: 342 IAEGMAFIEQRN---YIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPI 398 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K + +PE G ++KSD++SFG++++EIVT Sbjct: 399 K------WTAPEAINFGSSTIKSDVWSFGILLMEIVT 429
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 62.0 bits (149), Expect = 1e-09 Identities = 34/98 (34%), Positives = 55/98 (56%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLK 198 I+ +GL +LH+ IIHRD+K+ NVLLD KI+DFG ++ T+ Sbjct: 673 IVRETCQGLKFLHDK---HIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATM- 728 Query: 199 VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT +M+PE + K D++S G+M +E++ G+ Sbjct: 729 -VGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGE 765
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 62/99 (62%), Gaps = 2/99 (2%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +A G+ YL + + IHRD+ A N+L+ + I K++DFG+AR+ + Y Sbjct: 338 DMCSQVASGMSYLEQQN---YIHRDLAARNILVGEHKICKVADFGLARVIDEE---IYEA 391 Query: 196 KVIGTY--GYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + + +PE AM F++KSD++SFG+++ E++T Sbjct: 392 KLGAKFPIKWTAPEAAMYSRFTIKSDVWSFGIVLYEVIT 430
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 61/99 (61%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 756 MLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 812 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + +PE F+ SD++S+G+++ E+++ Sbjct: 813 GGKI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMS 849
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/106 (36%), Positives = 62/106 (58%), Gaps = 1/106 (0%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I +G+++ H R++HRD+K N+L+D + K++DFG+AR F G YT +V+ T Sbjct: 112 ILQGIVFCHSR---RVLHRDLKPQNLLIDSKGVIKLADFGLARAF-GIPVRVYTHEVV-T 166 Query: 211 YGYMSPEYAMDGV-FSMKSDIYSFGVMVLEIVTGKKNRGFYDAELD 345 Y +PE + V +S D++S G + EI T KK D+E+D Sbjct: 167 LWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIAT-KKPLFHGDSEID 211
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 62.0 bits (149), Expect = 1e-09 Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 15/183 (8%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQT 180 W+ R IA G+ YLH + IIHRD+ + N L+ N ++DFG+AR+ ++ Sbjct: 441 WSQRVSFAKDIAAGMAYLHS---MNIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKN 497 Query: 181 TAYTLK------------VIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGKKNRG 324 L+ V+G +M+PE + K DI+SFG+++ EI+ Sbjct: 498 QPEHLQNLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDIFSFGIVLCEIIGRVSADP 557 Query: 325 FY---DAELDLNLLGYAWTLWKEGRSTELLDEAMMGSSCDHSQVRRCIQVALLCVDMNPR 495 Y + LN+ G+ E +C S +A C D++P Sbjct: 558 DYLPRTTDFGLNVRGFL--------------ERYCPPACPPS----FFPIAACCCDLDPE 599 Query: 496 NRP 504 RP Sbjct: 600 KRP 602
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 61.6 bits (148), Expect = 2e-09 Identities = 36/98 (36%), Positives = 53/98 (54%), Gaps = 5/98 (5%) Frame = +1 Query: 31 IARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGT 210 I RGL +LH+ ++IHRD+K NVLL N K+ DFG++ D+T IGT Sbjct: 137 ILRGLSHLHQH---KVIHRDIKGQNVLLTENAEVKLVDFGVSAQL--DRTVGRRNTFIGT 191 Query: 211 YGYMSPEYAM-----DGVFSMKSDIYSFGVMVLEIVTG 309 +M+PE D + KSD++S G+ +E+ G Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEG 229
>AVR2B_RAT (P38445) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 513 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 14/116 (12%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED--------SRLRIIHRDMKASNVLLDRNMIPKISDFGIA 156 WN + ++RGL YLHED + I HRD K+ NVLL ++ ++DFG+A Sbjct: 285 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 344 Query: 157 RMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F + T +GT YM+PE ++G + ++ D+Y+ G+++ E+V+ Sbjct: 345 VRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELVS 399
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/99 (33%), Positives = 58/99 (58%) Frame = +1 Query: 16 EIITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL 195 ++ + +GL YL E + +I+HRD+K SN+L++ K+ DFG++ G + Sbjct: 161 KVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMAN 214 Query: 196 KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVTGK 312 +GT YMSPE +S++SDI+S G+ ++E+ G+ Sbjct: 215 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGR 253
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 61.6 bits (148), Expect = 2e-09 Identities = 36/94 (38%), Positives = 56/94 (59%), Gaps = 2/94 (2%) Frame = +1 Query: 40 GLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTLKVIGTYGY 219 GL YLH IIHRD+KA N+L+D + + KISDFGI++ L + G+ + Sbjct: 942 GLSYLHSKG---IIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFW 998 Query: 220 MSPEYAMDG--VFSMKSDIYSFGVMVLEIVTGKK 315 M+PE + +S K D++S G +VLE++ G++ Sbjct: 999 MAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRR 1032
>AVR2B_MOUSE (P27040) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 536 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 14/116 (12%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED--------SRLRIIHRDMKASNVLLDRNMIPKISDFGIA 156 WN + ++RGL YLHED + I HRD K+ NVLL ++ ++DFG+A Sbjct: 308 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 367 Query: 157 RMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F + T +GT YM+PE ++G + ++ D+Y+ G+++ E+V+ Sbjct: 368 VRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELVS 422
>AVR2B_PIG (Q66T47) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 14/116 (12%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED--------SRLRIIHRDMKASNVLLDRNMIPKISDFGIA 156 WN + ++RGL YLHED + I HRD K+ NVLL ++ ++DFG+A Sbjct: 284 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 343 Query: 157 RMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F + T +GT YM+PE ++G + ++ D+Y+ G+++ E+V+ Sbjct: 344 VRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRNAFLRIDMYAMGLVLWELVS 398
>AVR2B_HUMAN (Q13705) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 14/116 (12%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED--------SRLRIIHRDMKASNVLLDRNMIPKISDFGIA 156 WN + ++RGL YLHED + I HRD K+ NVLL ++ ++DFG+A Sbjct: 284 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 343 Query: 157 RMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F + T +GT YM+PE ++G + ++ D+Y+ G+++ E+V+ Sbjct: 344 VRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELVS 398
>AVR2B_BOVIN (Q95126) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 14/116 (12%) Frame = +1 Query: 1 WNTRFEIITGIARGLLYLHED--------SRLRIIHRDMKASNVLLDRNMIPKISDFGIA 156 WN + ++RGL YLHED + I HRD K+ NVLL ++ ++DFG+A Sbjct: 284 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 343 Query: 157 RMFGGDQTTAYTLKVIGTYGYMSPEYAMDGVFS------MKSDIYSFGVMVLEIVT 306 F + T +GT YM+PE ++G + ++ D+Y+ G+++ E+V+ Sbjct: 344 VRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELVS 398
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 61.6 bits (148), Expect = 2e-09 Identities = 34/99 (34%), Positives = 60/99 (60%), Gaps = 3/99 (3%) Frame = +1 Query: 19 IITGIARGLLYLHEDSRLRIIHRDMKASNVLLDRNMIPKISDFGIARMFGGDQTTAYTL- 195 ++ GIA G+ YL S + +HRD+ A N+L++ N++ K+SDFG++R+ D AYT Sbjct: 726 MLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 782 Query: 196 --KVIGTYGYMSPEYAMDGVFSMKSDIYSFGVMVLEIVT 306 K+ + SPE F+ SD +S+G+++ E+++ Sbjct: 783 GGKI--PIRWTSPEAIAYRKFTSASDAWSYGIVLWEVMS 819 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 87,095,071 Number of Sequences: 219361 Number of extensions: 1847925 Number of successful extensions: 7697 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6245 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6570 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4872342800 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
