ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd13j03 |
|---|---|
| Clone Library Name | barley_pub |
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 154 bits (388), Expect = 3e-37 Identities = 78/188 (41%), Positives = 117/188 (62%), Gaps = 3/188 (1%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKT 233 LT+ ++ A F+A + IGSGGFG YKA++A G +VAIK+L QG ++F AE++T Sbjct: 846 LTFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMET 905 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP---IDWRMLHKIALD 404 +G+ +H NLV L+GY E L+Y ++ G+LE + E+TK+ +DW KIA+ Sbjct: 906 IGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIG 965 Query: 405 VARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL 584 AR LA+LH +C+P I+HRD+K SN+LLD ++ A +SDF +++ + Sbjct: 966 AARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDTHLSVSTLAGT 1025 Query: 585 LGYVAPEY 608 GYV PEY Sbjct: 1026 PGYVPPEY 1033
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 148 bits (374), Expect = 1e-35 Identities = 81/201 (40%), Positives = 121/201 (60%), Gaps = 4/201 (1%) Frame = +3 Query: 18 REVTVF--VDIGAPLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIG 191 R V +F D L+ + ++++ SFN +N IG GGFG YKA + G VAIKRL+ Sbjct: 717 RSVVLFHNKDSNNELSLDDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGD 776 Query: 192 RFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP- 368 Q ++FQAEV+TL R +H NLV L+GY ++ LIY+++ G+L+ ++ E+ P Sbjct: 777 TGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGPP 836 Query: 369 -IDWRMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWE 545 +DW+ +IA A LAYLH +C P ILHRD+K SNILL + + A+L+DF +++ Sbjct: 837 SLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILP 896 Query: 546 FRNSCNHPVSRVLLGYVAPEY 608 + + LGY+ PEY Sbjct: 897 YDTHVTTDLVGT-LGYIPPEY 916
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 146 bits (368), Expect = 5e-35 Identities = 73/189 (38%), Positives = 114/189 (60%), Gaps = 4/189 (2%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKT 233 LT+ ++ A F+A +GSGGFG YKA++ G +VAIK+L QG ++F AE++T Sbjct: 847 LTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMET 906 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP----IDWRMLHKIAL 401 +G+ +H NLV L+GY E L+Y ++ G+LE + E++ + ++W KIA+ Sbjct: 907 IGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAI 966 Query: 402 DVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRV 581 AR LA+LH +C+P I+HRD+K SN+LLD ++ A +SDF +++ + Sbjct: 967 GAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAG 1026 Query: 582 LLGYVAPEY 608 GYV PEY Sbjct: 1027 TPGYVPPEY 1035
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 144 bits (362), Expect = 3e-34 Identities = 75/187 (40%), Positives = 111/187 (59%), Gaps = 2/187 (1%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKT 233 LT+ ++ A F+ + +GSGGFG YKA++ G +VAIK+L QG ++F AE++T Sbjct: 876 LTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMET 935 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPI--DWRMLHKIALDV 407 +G+ +H NLV L+GY E L+Y ++ G+LE + +R K I +W KIA+ Sbjct: 936 IGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGA 995 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLL 587 AR LA+LH NC+P I+HRD+K SN+LLD A +SDF +++ + Sbjct: 996 ARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP 1055 Query: 588 GYVAPEY 608 GYV PEY Sbjct: 1056 GYVPPEY 1062
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 143 bits (360), Expect = 5e-34 Identities = 75/180 (41%), Positives = 116/180 (64%), Gaps = 3/180 (1%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHD 254 A+ +F+ N +G GGFG YK +A G LVA+KRL R QG + QFQ EV+ + H Sbjct: 285 ASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHR 344 Query: 255 NLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQER--TKRPIDWRMLHKIALDVARALAYL 428 NL+ L G+ ++ +E L+Y ++ G++ ++ER ++ P+DW +IAL AR LAYL Sbjct: 345 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 404 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPEY 608 HD+C P+I+HRDVK +NILLD E+ A + DF ++K +++++ R +G++APEY Sbjct: 405 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAK-LMDYKDTHVTTAVRGTIGHIAPEY 463
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 143 bits (360), Expect = 5e-34 Identities = 75/187 (40%), Positives = 111/187 (59%), Gaps = 2/187 (1%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKT 233 LT+ ++ A F+ + +GSGGFG YKA++ G +VAIK+L QG ++F AE++T Sbjct: 876 LTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMET 935 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPI--DWRMLHKIALDV 407 +G+ +H NLV L+GY E L+Y ++ G+LE + +R K I +W KIA+ Sbjct: 936 IGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGA 995 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLL 587 AR LA+LH NC+P I+HRD+K SN+LLD A +SDF +++ + Sbjct: 996 ARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP 1055 Query: 588 GYVAPEY 608 GYV PEY Sbjct: 1056 GYVPPEY 1062
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 140 bits (354), Expect = 2e-33 Identities = 75/197 (38%), Positives = 118/197 (59%), Gaps = 2/197 (1%) Frame = +3 Query: 24 VTVFVDIGAPLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQG 203 V +F L+Y+ ++ + SF+ +N IG GGFG YKA + G VAIK+L+ Q Sbjct: 712 VVLFQSNDKELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQI 771 Query: 204 IQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP--IDW 377 ++F+AEV+TL R +H NLV L G+ ++ LIY+++ G+L+ ++ ER P + W Sbjct: 772 EREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKW 831 Query: 378 RMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNS 557 + +IA A+ L YLH+ C P ILHRD+K SNILLD + ++L+DF +++ + Sbjct: 832 KTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPYETH 891 Query: 558 CNHPVSRVLLGYVAPEY 608 + + LGY+ PEY Sbjct: 892 VSTDLVGT-LGYIPPEY 907
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 139 bits (351), Expect = 5e-33 Identities = 72/185 (38%), Positives = 113/185 (61%), Gaps = 5/185 (2%) Frame = +3 Query: 69 VVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCR 248 +V A F+ N IG GGFG YKA + VA+K+L+ + QG ++F AE++TLG+ + Sbjct: 910 IVEATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVK 969 Query: 249 HDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT--KRPIDWRMLHKIALDVARALA 422 H NLV+L+GY E L+Y ++ G+L+ +++ +T +DW KIA+ AR LA Sbjct: 970 HPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLA 1029 Query: 423 YLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL---LGY 593 +LH +P I+HRD+K SNILLD ++ ++DF +++ ++C VS V+ GY Sbjct: 1030 FLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLI----SACESHVSTVIAGTFGY 1085 Query: 594 VAPEY 608 + PEY Sbjct: 1086 IPPEY 1090
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 138 bits (347), Expect = 1e-32 Identities = 75/187 (40%), Positives = 108/187 (57%), Gaps = 2/187 (1%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKT 233 LT+ +++A F+ + IGSGGFG YKA + G VAIK+L QG ++F AE++T Sbjct: 871 LTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMET 930 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKR--PIDWRMLHKIALDV 407 +G+ +H NLV L+GY E L+Y F+ G+LE + + K ++W KIA+ Sbjct: 931 IGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGS 990 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLL 587 AR LA+LH NC P I+HRD+K SN+LLD A +SDF +++ + Sbjct: 991 ARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP 1050 Query: 588 GYVAPEY 608 GYV PEY Sbjct: 1051 GYVPPEY 1057
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 135 bits (340), Expect = 9e-32 Identities = 74/189 (39%), Positives = 108/189 (57%), Gaps = 4/189 (2%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKT 233 L + ++ A F+A++ IG GGFG +KA + G VAIK+L QG ++F AE++T Sbjct: 826 LKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMET 885 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQ-ERT---KRPIDWRMLHKIAL 401 LG+ +H NLV L+GY E L+Y F+ G+LE + RT +R + W KIA Sbjct: 886 LGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAK 945 Query: 402 DVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRV 581 A+ L +LH NC+P I+HRD+K SN+LLD + A +SDF +++ + Sbjct: 946 GAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVSTLAG 1005 Query: 582 LLGYVAPEY 608 GYV PEY Sbjct: 1006 TPGYVPPEY 1014
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 134 bits (336), Expect = 3e-31 Identities = 75/199 (37%), Positives = 119/199 (59%), Gaps = 6/199 (3%) Frame = +3 Query: 36 VDIGAPLTYETVVRAA-GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRF--QGI 206 V+ G L V+R+ +F++ N +GSGGFG YK E+ G +A+KR+ G +G Sbjct: 569 VEAGNMLISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGF 628 Query: 207 QQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTK---RPIDW 377 +F++E+ L + RH +LVTL+GY L +E L+Y ++P G L R + E ++ +P+ W Sbjct: 629 AEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLW 688 Query: 378 RMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNS 557 + +ALDVAR + YLH +HRD+KPSNILL ++ A ++DF + + E + S Sbjct: 689 KQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGS 748 Query: 558 CNHPVSRVLLGYVAPEYAM 614 ++ GY+APEYA+ Sbjct: 749 IETRIAGT-FGYLAPEYAV 766
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 129 bits (324), Expect = 7e-30 Identities = 76/191 (39%), Positives = 106/191 (55%), Gaps = 5/191 (2%) Frame = +3 Query: 57 TYETVVRAAGSFNASNCIGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKT 233 T++ + A G+F + +G GGFG +K I +VAIK+L QGI++F EV T Sbjct: 92 TFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVLT 151 Query: 234 LGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQ--ERTKRPIDWRMLHKIALDV 407 L H NLV LIG+ + L+Y ++P G+LE + K+P+DW KIA Sbjct: 152 LSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGA 211 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL- 584 AR L YLHD P +++RD+K SNILL +Y LSDF ++K H +RV+ Sbjct: 212 ARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPS--GDKTHVSTRVMG 269 Query: 585 -LGYVAPEYAM 614 GY AP+YAM Sbjct: 270 TYGYCAPDYAM 280
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 128 bits (322), Expect = 1e-29 Identities = 77/198 (38%), Positives = 112/198 (56%), Gaps = 14/198 (7%) Frame = +3 Query: 57 TYETVVRAAGSFNASNCIGSGGFGATYKAEI----------APGILVAIKRLAIGRFQGI 206 T+ + A +F + +G GGFG+ +K I G+++A+K+L +QG Sbjct: 58 TFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGWQGH 117 Query: 207 QQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTK--RPIDWR 380 Q++ AEV LG+ H NLV LIGY L D L+Y F+P G+LE + R +P+ W Sbjct: 118 QEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSWT 177 Query: 381 MLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSC 560 + K+AL A+ LA+LH N +++RD K SNILLD+EY A LSDF ++K S Sbjct: 178 LRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTGDKS- 235 Query: 561 NHPVSRVL--LGYVAPEY 608 H +R++ GY APEY Sbjct: 236 -HVSTRIMGTYGYAAPEY 252
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 127 bits (320), Expect = 2e-29 Identities = 68/173 (39%), Positives = 104/173 (60%), Gaps = 3/173 (1%) Frame = +3 Query: 102 NCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQ--FQAEVKTLGRCRHDNLVTLIG 275 N IG GG G Y+ + + VAIKRL +GR G F AE++TLGR RH ++V L+G Sbjct: 696 NIIGKGGAGIVYRGSMPNNVDVAIKRL-VGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLG 754 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 Y + L+Y ++P G+L + + W H++A++ A+ L YLH +C P IL Sbjct: 755 YVANKDTNLLLYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLIL 814 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWE-FRNSCNHPVSRVLLGYVAPEYA 611 HRDVK +NILLD+++ A+++DF ++K + + C ++ GY+APEYA Sbjct: 815 HRDVKSNNILLDSDFEAHVADFGLAKFLVDGAASECMSSIAG-SYGYIAPEYA 866
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 125 bits (314), Expect = 1e-28 Identities = 77/191 (40%), Positives = 111/191 (58%), Gaps = 14/191 (7%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYK-----AEIAP-----GILVAIKRLAIGRFQGIQQFQAEV 227 A +F + +G GGFG +K + +AP GI++A+KRL FQG +++ AE+ Sbjct: 64 ATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQGHREWLAEI 123 Query: 228 KTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTK--RPIDWRMLHKIAL 401 LG+ H NLV LIGY L + L+Y F+ G+LE + R +P+ W ++AL Sbjct: 124 NYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMAL 183 Query: 402 DVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRV 581 AR LA+LH N P++++RD K SNILLD+ Y A LSDF +++ NS H +RV Sbjct: 184 GAARGLAFLH-NAQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPMGDNS--HVSTRV 240 Query: 582 L--LGYVAPEY 608 + GY APEY Sbjct: 241 MGTQGYAAPEY 251
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 125 bits (314), Expect = 1e-28 Identities = 73/196 (37%), Positives = 108/196 (55%), Gaps = 2/196 (1%) Frame = +3 Query: 33 FVDIGAPLT-YETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ 209 F ++ PL ETVV+A +F++ N +G GGFG YK + G +A+KRL+ QG Sbjct: 508 FEELELPLIEMETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTD 567 Query: 210 QFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKR-PIDWRML 386 +F EV + R +H NLV ++G + E LIY +L +L+ ++ +T+R ++W Sbjct: 568 EFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRSKLNWNER 627 Query: 387 HKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNH 566 I VAR L YLH + RI+HRD+K SNILLD +SDF +++ N Sbjct: 628 FDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERDETEANT 687 Query: 567 PVSRVLLGYVAPEYAM 614 GY++PEYAM Sbjct: 688 MKVVGTYGYMSPEYAM 703
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 123 bits (309), Expect = 4e-28 Identities = 76/191 (39%), Positives = 110/191 (57%), Gaps = 14/191 (7%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKAEI----------APGILVAIKRLAIGRFQGIQQFQAEV 227 A +F + +G GGFG +K I G+++A+K+L +QG Q++ AEV Sbjct: 64 ATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQDGWQGHQEWLAEV 123 Query: 228 KTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTK--RPIDWRMLHKIAL 401 LG+ H +LV LIGY L D L+Y F+P G+LE + R +P+ W++ K+AL Sbjct: 124 NYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYFQPLSWKLRLKVAL 183 Query: 402 DVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRV 581 A+ LA+LH + R+++RD K SNILLD+EY A LSDF ++K S H +RV Sbjct: 184 GAAKGLAFLHSS-ETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIGDKS--HVSTRV 240 Query: 582 L--LGYVAPEY 608 + GY APEY Sbjct: 241 MGTHGYAAPEY 251
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 123 bits (309), Expect = 4e-28 Identities = 67/200 (33%), Positives = 105/200 (52%), Gaps = 2/200 (1%) Frame = +3 Query: 18 REVTVFVDIGAPLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAI-GR 194 +E+ + G V+ A + N IG G G YKA ++P + A+K+L G Sbjct: 792 QEIAISAQEGDGSLLNKVLEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGI 851 Query: 195 FQGIQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTK-RPI 371 G E++T+G+ RH NL+ L + L ++Y ++ G+L + E +P+ Sbjct: 852 KNGSVSMVREIETIGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPL 911 Query: 372 DWRMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 DW H IA+ A LAYLH +C P I+HRD+KP NILLD++ ++SDF ++K + Sbjct: 912 DWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSA 971 Query: 552 NSCNHPVSRVLLGYVAPEYA 611 S + +GY+APE A Sbjct: 972 TSIPSNTVQGTIGYMAPENA 991
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 122 bits (306), Expect = 8e-28 Identities = 74/190 (38%), Positives = 103/190 (54%), Gaps = 5/190 (2%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKAEI-APGILVAIKRLAIGRFQGIQQFQAEVKTL 236 + + A +F+ +G GGFG YK + + G +VA+K+L QG ++F EV L Sbjct: 76 FRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLML 135 Query: 237 GRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT--KRPIDWRMLHKIALDVA 410 H NLV LIGY + L+Y F+P G+LE + + K +DW M KIA A Sbjct: 136 SLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAA 195 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL-- 584 + L +LHD P +++RD K SNILLD + LSDF ++K S H +RV+ Sbjct: 196 KGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKS--HVSTRVMGT 253 Query: 585 LGYVAPEYAM 614 GY APEYAM Sbjct: 254 YGYCAPEYAM 263
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 121 bits (304), Expect = 1e-27 Identities = 73/189 (38%), Positives = 104/189 (55%), Gaps = 12/189 (6%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYK----------AEIAPGILVAIKRLAIGRFQGIQQFQAEV 227 A +F + +G GGFG Y+ + + G++VAIKRL QG ++++EV Sbjct: 82 ATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQGFAEWRSEV 141 Query: 228 KTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDV 407 LG H NLV L+GY D E+ L+Y F+P G+LE + R P W + KI + Sbjct: 142 NFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRND-PFPWDLRIKIVIGA 200 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL- 584 AR LA+LH + +++RD K SNILLD+ Y A LSDF ++K S H +R++ Sbjct: 201 ARGLAFLH-SLQREVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEKS--HVTTRIMG 257 Query: 585 -LGYVAPEY 608 GY APEY Sbjct: 258 TYGYAAPEY 266
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 118 bits (295), Expect = 2e-26 Identities = 72/186 (38%), Positives = 104/186 (55%), Gaps = 3/186 (1%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLG 239 Y VV +F IG GGFG Y I G VA+K L+ QG ++F+AEV L Sbjct: 566 YSEVVNITNNFE--RVIGKGGFGKVYHGVIN-GEQVAVKVLSEESAQGYKEFRAEVDLLM 622 Query: 240 RCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARAL 419 R H NL +L+GY + M LIY ++ NL ++ + + W KI+LD A+ L Sbjct: 623 RVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFILSWEERLKISLDAAQGL 682 Query: 420 AYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL---LG 590 YLH+ C P I+HRDVKP+NILL+ + A ++DF +S++ F + +S V+ +G Sbjct: 683 EYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRS---FSVEGSGQISTVVAGSIG 739 Query: 591 YVAPEY 608 Y+ PEY Sbjct: 740 YLDPEY 745
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 112 bits (279), Expect = 1e-24 Identities = 72/188 (38%), Positives = 99/188 (52%), Gaps = 2/188 (1%) Frame = +3 Query: 51 PLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVK 230 P T E + +A + IG GGFG+ Y+ + G VA+K + QG ++F E+ Sbjct: 585 PFTLEYIEQATEQYKT--LIGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELN 642 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGN-LERFIQERTKRPI-DWRMLHKIALD 404 L +H+NLV L+GY + L+Y F+ G+ L+R E +KR I DW IAL Sbjct: 643 LLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALG 702 Query: 405 VARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL 584 AR LAYLH ++HRDVK SNILLD A ++DF SK + +S R Sbjct: 703 AARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGT 762 Query: 585 LGYVAPEY 608 GY+ PEY Sbjct: 763 AGYLDPEY 770
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 110 bits (276), Expect = 2e-24 Identities = 72/188 (38%), Positives = 98/188 (52%), Gaps = 2/188 (1%) Frame = +3 Query: 51 PLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVK 230 P T E + A + IG GGFG+ Y+ + G VA+K + QG ++F E+ Sbjct: 584 PFTLEYIELATEKYKT--LIGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELN 641 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGN-LERFIQERTKRPI-DWRMLHKIALD 404 L +H+NLV L+GY + L+Y F+ G+ L+R E KR I DW IAL Sbjct: 642 LLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALG 701 Query: 405 VARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL 584 AR LAYLH ++HRDVK SNILLD+ A ++DF SK + +S R Sbjct: 702 AARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQEGDSYVSLEVRGT 761 Query: 585 LGYVAPEY 608 GY+ PEY Sbjct: 762 AGYLDPEY 769
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 109 bits (272), Expect = 7e-24 Identities = 70/190 (36%), Positives = 99/190 (52%), Gaps = 14/190 (7%) Frame = +3 Query: 81 AGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQ----------FQAEVK 230 A + N IG G G YK E+ G +VA+K+L G + F AEV+ Sbjct: 680 ADCLDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVE 739 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPI--DWRMLHKIALD 404 TLG RH ++V L S L+Y ++P G+L + K + W +IALD Sbjct: 740 TLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALD 799 Query: 405 VARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL 584 A L+YLH +CVP I+HRDVK SNILLD++Y A ++DF ++K + +S + Sbjct: 800 AAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIA 859 Query: 585 --LGYVAPEY 608 GY+APEY Sbjct: 860 GSCGYIAPEY 869
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 105 bits (263), Expect = 8e-23 Identities = 66/185 (35%), Positives = 96/185 (51%), Gaps = 1/185 (0%) Frame = +3 Query: 57 TYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTL 236 +Y +V+A F +G G G YK + VA+K+L R QG + FQAE+ + Sbjct: 525 SYRELVKATRKFKVE--LGRGESGTVYKGVLEDDRHVAVKKLENVR-QGKEVFQAELSVI 581 Query: 237 GRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFI-QERTKRPIDWRMLHKIALDVAR 413 GR H NLV + G+ S L+ ++ G+L + E +DW IAL VA+ Sbjct: 582 GRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAK 641 Query: 414 ALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGY 593 LAYLH C+ ++H DVKP NILLD + ++DF + K ++ N R LGY Sbjct: 642 GLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGSTQNVSHVRGTLGY 701 Query: 594 VAPEY 608 +APE+ Sbjct: 702 IAPEW 706
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 105 bits (263), Expect = 8e-23 Identities = 60/189 (31%), Positives = 100/189 (52%), Gaps = 5/189 (2%) Frame = +3 Query: 57 TYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRL--AIGRFQGIQQFQAEVK 230 +YE + +A G F+ + +G G F +K + G +VA+KR A + ++F E+ Sbjct: 494 SYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNELD 553 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT---KRPIDWRMLHKIAL 401 L R H +L+ L+GY SE L+Y F+ G+L + + + K+ ++W IA+ Sbjct: 554 LLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAV 613 Query: 402 DVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRV 581 AR + YLH P ++HRD+K SNIL+D ++ A ++DF +S + + Sbjct: 614 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSGTPLSELPAG 673 Query: 582 LLGYVAPEY 608 LGY+ PEY Sbjct: 674 TLGYLDPEY 682
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 105 bits (261), Expect = 1e-22 Identities = 63/175 (36%), Positives = 100/175 (57%), Gaps = 7/175 (4%) Frame = +3 Query: 102 NCIGSGGFGATYKAEIAPGILVAIKRLA----IGRFQGIQQFQAEVKTLGRCRHDNLVTL 269 N +G GGFG YK + VA+K+LA I + QQF E+K + +C+H+NLV L Sbjct: 190 NKMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 248 Query: 270 IGYHLSDSEMFLIYNFLPGGN-LERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 +G+ ++ L+Y ++P G+ L+R P+ W M KIA A + +LH+N Sbjct: 249 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN--- 305 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL--LGYVAPE 605 +HRD+K +NILLD +TA +SDF +++ + +F + SR++ Y+APE Sbjct: 306 HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV--MTSRIVGTTAYMAPE 358
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 99.8 bits (247), Expect = 6e-21 Identities = 59/175 (33%), Positives = 96/175 (54%), Gaps = 7/175 (4%) Frame = +3 Query: 102 NCIGSGGFGATYKAEIAPGILVAIKRLA----IGRFQGIQQFQAEVKTLGRCRHDNLVTL 269 N +G GGFG YK + +VA+K+L I + QQF E+K + C+H+NLV L Sbjct: 190 NRMGEGGFGVVYKGCVN-NTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVEL 248 Query: 270 IGYHLSDSEMFLIYNFLPGGN-LERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 +G+ + L+Y ++P G+ L+R P+ W K+A A + +LH+N Sbjct: 249 LGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHEN--- 305 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL--LGYVAPE 605 +HRD+K +NILLD ++TA +SDF +++ + + SR++ Y+APE Sbjct: 306 HHIHRDIKSANILLDKDFTAKISDFGLARASARLAQTV--MTSRIVGTTAYMAPE 358
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/161 (36%), Positives = 87/161 (54%), Gaps = 6/161 (3%) Frame = +3 Query: 69 VVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRL---AIGRFQGIQQ-FQAEVKTL 236 + R +F+ IG GGFG Y+A + + A+KRL A + ++Q F EV+ L Sbjct: 205 ISRGTHNFSEELKIGEGGFGCVYRA-VMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQL 263 Query: 237 GRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKR--PIDWRMLHKIALDVA 410 R RH N+V GY + L+Y FLP G+LE + +T+ P+ W I L A Sbjct: 264 SRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTA 323 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 RA+ +LH + P ++H D+K SN+LLD T L DF +++ Sbjct: 324 RAIQFLHQDS-PSLIHGDIKSSNVLLDERLTPKLGDFGLAR 363
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 89.0 bits (219), Expect = 1e-17 Identities = 54/166 (32%), Positives = 87/166 (52%), Gaps = 3/166 (1%) Frame = +3 Query: 45 GAPLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAE 224 G LT + V+ A G +G YKA+++ G +A++ L G + Sbjct: 363 GENLTLDDVLNATGQVMEKT-----SYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPV 417 Query: 225 VKTLGRCRHDNLVTLIGYHLSD-SEMFLIYNFLPGGNLERFIQERTKRP--IDWRMLHKI 395 ++ LGR RH+NLV L ++ E LIY++LP +L + E R ++W HKI Sbjct: 418 IRQLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKI 477 Query: 396 ALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 AL +AR LAYLH I+H +++ N+L+D+ + A L++F + K Sbjct: 478 ALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDK 523
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 87.4 bits (215), Expect = 3e-17 Identities = 55/155 (35%), Positives = 78/155 (50%), Gaps = 6/155 (3%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIAPGILVAIKRLA----IGRFQGIQQFQAEVKTLGRCRHD 254 +F+ IG GGFG Y+A + A+KRL + Q F EV+ L R RH Sbjct: 211 NFSEELRIGEGGFGCVYRA-VMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHP 269 Query: 255 NLVTLIGYHLSDSEMFLIYNFLPGGNLE--RFIQERTKRPIDWRMLHKIALDVARALAYL 428 N+V GY L+Y FLP G+LE +Q + P+ W I L ARA+ +L Sbjct: 270 NIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFL 329 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 H + P ++H D+K SN+LLD L DF +++ Sbjct: 330 HQDS-PSLIHGDIKSSNVLLDERLMPKLGDFGLAR 363
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 80.5 bits (197), Expect = 4e-15 Identities = 51/166 (30%), Positives = 82/166 (49%), Gaps = 10/166 (6%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIG------RFQGIQQF 215 + Y + A ++ N +G GGFG Y+ + + VAIK + + +QQ Sbjct: 201 IDYAELENATDGWSPDNRLGQGGFGDVYRGKWKQ-LDVAIKVMNYRSPNIDQKMVELQQS 259 Query: 216 QAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLE-RFIQERTKRP---IDWRM 383 E+K L RHDN++ L GY + + L+Y + GG+LE R + + P + W+ Sbjct: 260 YNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQ 319 Query: 384 LHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDF 521 I+L AR + +LH ++H D+KP+NILLD + DF Sbjct: 320 RFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDF 365
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 79.0 bits (193), Expect = 1e-14 Identities = 52/150 (34%), Positives = 80/150 (53%), Gaps = 3/150 (2%) Frame = +3 Query: 93 NASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQG--IQQFQAEVKTLGRCRHDNLVT 266 N IG+G FG ++AE G VA+K L F + +F EV + R RH N+V Sbjct: 552 NIKEKIGAGSFGTVHRAEWH-GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVL 610 Query: 267 LIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIALDVARALAYLHDNCV 443 +G + ++ +L G+L R + + R +D R +A DVA+ + YLH N Sbjct: 611 FMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLH-NRN 669 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 P I+HRD+K N+L+D +YT + DF +S+ Sbjct: 670 PPIVHRDLKSPNLLVDKKYTVKVCDFGLSR 699
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 75.9 bits (185), Expect = 9e-14 Identities = 51/147 (34%), Positives = 82/147 (55%), Gaps = 6/147 (4%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY-- 278 +G GGFGA ++A A + VA+K + ++ EVK + RH+N++ L+G Sbjct: 28 VGKGGFGAVFRARHTAWNLDVAVKIV------NSKKISREVKAMVNLRHENVLLLLGVTE 81 Query: 279 HLSDSEMF---LIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPR 449 +L ++ L+ F+ G+L +Q RP W +L ++ +V + YLH + P Sbjct: 82 NLEWDYVYGPALVTGFMENGSLSGLLQPSCPRP--WPLLCRLLEEVVLGMCYLH-SLNPS 138 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVS 530 +LHRD+KPSN+LLD E A L+DF +S Sbjct: 139 LLHRDLKPSNVLLDLELHAKLADFGLS 165
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 73.6 bits (179), Expect = 4e-13 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YKA+ +L A K + + ++ + E+ L C H N+V L+ Sbjct: 40 LGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++ ++++ F GG ++ + E +RP+ + + AL YLHDN +I+HRD Sbjct: 100 YENNLWILIEFCAGGAVDAVMLE-LERPLTESQIQVVCKQTLEALNYLHDN---KIIHRD 155 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K NIL + L+DF VS Sbjct: 156 LKAGNILFTLDGDIKLADFGVS 177
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 73.6 bits (179), Expect = 4e-13 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YKA+ +L A K + + ++ + E+ L C H N+V L+ Sbjct: 40 LGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++ ++++ F GG ++ + E +RP+ + + AL YLHDN +I+HRD Sbjct: 100 YENNLWILIEFCAGGAVDAVMLE-LERPLTESQIQVVCKQTLEALNYLHDN---KIIHRD 155 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K NIL + L+DF VS Sbjct: 156 LKAGNILFTLDGDIKLADFGVS 177
>SLK_RAT (O08815) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1206 Score = 73.6 bits (179), Expect = 4e-13 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YKA+ +L A K + + ++ + E+ L C H N+V L+ Sbjct: 40 LGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++ ++++ F GG ++ + E +RP+ + + AL YLHDN +I+HRD Sbjct: 100 YENNLWILIEFCAGGAVDAVMLE-LERPLTESQIQVVCKQTLEALNYLHDN---KIIHRD 155 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K NIL + L+DF VS Sbjct: 156 LKAGNILFTLDGDIKLADFGVS 177
>SLK_HUMAN (Q9H2G2) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9) Length = 1235 Score = 72.8 bits (177), Expect = 8e-13 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YKA+ +L A K + + ++ + E+ L C H N+V L+ Sbjct: 40 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++ ++++ F GG ++ + E +RP+ + + AL YLHDN +I+HRD Sbjct: 100 YENNLWILIEFCAGGAVDAVMLE-LERPLTESQIQVVCKQTLDALNYLHDN---KIIHRD 155 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K NIL + L+DF VS Sbjct: 156 LKAGNILFTLDGDIKLADFGVS 177
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 72.4 bits (176), Expect = 1e-12 Identities = 52/182 (28%), Positives = 86/182 (47%), Gaps = 9/182 (4%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIG-------RFQG-IQQFQAEVKTLG 239 S+ IG G FG Y + G L+A+K++ I + Q IQ+ + EVK L Sbjct: 68 SWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLK 127 Query: 240 RCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARAL 419 H N+V +G D + ++ F+PGG++ +++ P ++ + L Sbjct: 128 NLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEK--FGPFPESVVRTYTRQLLLGL 185 Query: 420 AYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVA 599 YLH++ I+HRD+K +NIL+DN+ L+DF SK E + ++A Sbjct: 186 EYLHNHA---IMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMA 242 Query: 600 PE 605 PE Sbjct: 243 PE 244
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 72.0 bits (175), Expect = 1e-12 Identities = 51/146 (34%), Positives = 76/146 (52%), Gaps = 4/146 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRF---QGIQQFQAEVKTLGRCRHDNLVTLIGY 278 IGSG FG YK I VAIKR + + F EV L + H ++ +G Sbjct: 570 IGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 628 Query: 279 HLSDSEMF-LIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 L+D F ++ ++ GG+L + E+ KR +D + IA+DVA+ + YLH N I+ Sbjct: 629 CLNDPSQFAIVTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLH-NLTQPII 686 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSK 533 HRD+ NILL + A ++DF S+ Sbjct: 687 HRDLNSHNILLYEDGHAVVADFGESR 712
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YKA+ G L A K + + ++ + E++ L C H +V L+G + Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 D +++++ F PGG ++ + E R + + + + AL +LH RI+HRD Sbjct: 102 HDGKLWIMIEFCPGGAVDAIMLE-LDRGLTEPQIQVVCRQMLEALNFLHSK---RIIHRD 157 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K N+L+ E L+DF VS Sbjct: 158 LKAGNVLMTLEGDIRLADFGVS 179
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 4/146 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRF---QGIQQFQAEVKTLGRCRHDNLVTLIGY 278 IGSG FG YK I VAIKR + + F EV L + H +V +G Sbjct: 468 IGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 526 Query: 279 HLSDSEMF-LIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 L D F ++ ++ GG+L + E+ KR +D + IA+DVA+ + YLH P I+ Sbjct: 527 CLDDPSQFAIVTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLHSLTQP-II 584 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSK 533 HRD+ NILL + A ++DF S+ Sbjct: 585 HRDLNSHNILLYEDGHAVVADFGESR 610
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 4/158 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPG-ILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRCRHDN 257 F +G G FG Y A + +VA+K L + G++ Q + EV+ +H N Sbjct: 16 FEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRN 75 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L Y D+ ++LI + PGG L + +Q K +D + I +++ AL Y H+ Sbjct: 76 ILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQK--LDQQRTATIIQELSDALTYCHEK 133 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 +++HRD+KP N+LL +SDF S T R Sbjct: 134 ---KVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLR 168
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/143 (33%), Positives = 79/143 (55%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G KA P G+++A K + + ++ Q E++ L C +V G Sbjct: 78 LGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAF 137 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ ++E + P D +L K+++ V R LAYL + +I+HR Sbjct: 138 YSDGEISICMEHMDGGSLDQVLKEAKRIPED--ILGKVSIAVLRGLAYLREK--HQIMHR 193 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 194 DVKPSNILVNSRGEIKLCDFGVS 216
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 71.6 bits (174), Expect = 2e-12 Identities = 51/177 (28%), Positives = 82/177 (46%), Gaps = 4/177 (2%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVT 266 SF IG GGFG Y A+ G VAIK+ IG + + E+KT+ RH N+V Sbjct: 12 SFQNLQQIGQGGFGVVYSAQRENGEKVAIKK--IGNAASQTRIKEEIKTMKLLRHRNIVQ 69 Query: 267 LIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 + E +L+ GG+L ++++ K P+D I + A+ Y+HD Sbjct: 70 FYETFFENGETYLVMELCEGGSLMDYVKQ--KGPLDDSTAVHILRQLIAAVKYIHDE--- 124 Query: 447 RILHRDVKPSNILL----DNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 ILHRD+ N+ + + T L DF ++ + +C + G++AP+ Sbjct: 125 NILHRDLSAGNVFIKDATKSTITVKLGDFGLATNLGQHGTACTIVGTP---GFIAPQ 178
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 4/146 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRF---QGIQQFQAEVKTLGRCRHDNLVTLIGY 278 IGSG FG YK I VAIKR + + F EV L + H +V +G Sbjct: 467 IGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 525 Query: 279 HLSDSEMF-LIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 L D F ++ ++ GG+L + E+ KR +D + IA+DVA+ + YLH P I+ Sbjct: 526 CLDDPSQFAIVTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLHSLTQP-II 583 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSK 533 HRD+ NILL + A ++DF S+ Sbjct: 584 HRDLNSHNILLYEDGHAVVADFGESR 609
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/175 (29%), Positives = 96/175 (54%), Gaps = 3/175 (1%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRF-QGIQQFQA-EVKTLGRCRHDNL 260 +N + +G G +G Y+A + A G +VA+K++ + R +GI Q EV L H N+ Sbjct: 23 YNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHPNI 82 Query: 261 VTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 V L+ +D +++LI+ ++ +L++ +++R L KI + L++ H + Sbjct: 83 VNLLDVICADGKLYLIFEYVDH-DLKKALEKRGGA-FTGTTLKKIIYQLLEGLSFCHRH- 139 Query: 441 VPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RI+HRD+KP+NIL+ + + ++DF +++ ++ H V V L Y APE Sbjct: 140 --RIVHRDLKPANILVTTDNSVKIADFGLARAFQIPMHTYTHEV--VTLWYRAPE 190
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 71.2 bits (173), Expect = 2e-12 Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 10/206 (4%) Frame = +3 Query: 18 REVTVFVDIGAPLTYETV-VRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIG 191 R+ VF +P TV ++ + IG G FG Y + G L+A+K++ I Sbjct: 43 RKSMVFAKSQSPPNNSTVQIKPPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIT 102 Query: 192 -------RFQG-IQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFI 347 + Q IQ+ + EVK L H N+V +G D + ++ F+PGG++ + Sbjct: 103 SNCASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLL 162 Query: 348 QERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWV 527 ++ P ++ + L YLH++ I+HRD+K +NIL+DN+ L+DF Sbjct: 163 EKFGAFPES--VVRTYTNQLLLGLEYLHNHA---IMHRDIKGANILVDNQGCIKLADFGA 217 Query: 528 SKTTWEFRNSCNHPVSRVLLGYVAPE 605 SK E + ++APE Sbjct: 218 SKQVAELATISGAKSMKGTPYWMAPE 243
>STK10_MOUSE (O55098) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 966 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YKA+ G L A K + + ++ + E++ L C H +V L+G + Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 D +++++ F PGG ++ + E R + + + + AL +LH RI+HRD Sbjct: 102 YDGKLWIMIEFCPGGAVDAIMLE-LDRGLTEPQIQVVCRQMLEALNFLHGK---RIIHRD 157 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K N+L+ E L+DF VS Sbjct: 158 LKAGNVLMTLEGDIRLADFGVS 179
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/143 (33%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G KA P G ++A K + + ++ Q E++ L C +V G Sbjct: 78 LGAGNGGVVTKARHRPSGFIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAF 137 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ ++E + P D +L K+++ V R LAYL + +I+HR Sbjct: 138 YSDGEISICMEHMDGGSLDQVLKEAKRIPED--ILGKVSIAVLRGLAYLREK--HQIMHR 193 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 194 DVKPSNILVNSRGEIKLCDFGVS 216
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/172 (30%), Positives = 83/172 (48%), Gaps = 3/172 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S IGSG FG YK + + V I ++ + +Q F+ EV L + RH N++ +GY Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 D+ + ++ + G +L + + + TK L IA A+ + YLH I+ Sbjct: 412 MTKDN-LAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYLH---AKNII 465 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+K +NI L T + DF ++ K+ W P VL ++APE Sbjct: 466 HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL--WMAPE 515
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/172 (30%), Positives = 83/172 (48%), Gaps = 3/172 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S IGSG FG YK + + V I ++ + +Q F+ EV L + RH N++ +GY Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 D+ + ++ + G +L + + + TK L IA A+ + YLH I+ Sbjct: 412 MTKDN-LAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYLH---AKNII 465 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+K +NI L T + DF ++ K+ W P VL ++APE Sbjct: 466 HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL--WMAPE 515
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/146 (35%), Positives = 74/146 (50%), Gaps = 11/146 (7%) Frame = +3 Query: 117 GGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS--- 287 GGFG +KA++ VA+K I Q Q + EV +L +H+N++ IG Sbjct: 201 GGFGCVWKAQLL-NEYVAVKIFPIQDKQSWQN-EYEVYSLPGMKHENILQFIGAEKRGTS 258 Query: 288 -DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH-------DNCV 443 D +++LI F G+L F++ + W L IA +AR LAYLH D Sbjct: 259 VDVDLWLITAFHEKGSLSDFLKANV---VSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDF 521 P I HRD+K N+LL N TA ++DF Sbjct: 316 PAISHRDIKSKNVLLKNNLTACIADF 341
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/175 (27%), Positives = 89/175 (50%), Gaps = 9/175 (5%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQG--------IQQFQAEVKTLGRCRHDNL 260 IG G FGA Y + G ++A+K++ + ++ ++ ++EV TL H N+ Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNI 1240 Query: 261 VTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 V +G+ ++ L ++ GG++ I R D ++ + V + LAYLH Sbjct: 1241 VQYLGFENKNNIYSLFLEYVAGGSVGSLI--RMYGRFDEPLIKHLTTQVLKGLAYLHSK- 1297 Query: 441 VPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 ILHRD+K N+LLD + +SDF +S+ + + ++ + + R + ++APE Sbjct: 1298 --GILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTM-RGTVFWMAPE 1349
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/172 (30%), Positives = 83/172 (48%), Gaps = 3/172 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S IGSG FG YK + + V I ++ + +Q F+ EV L + RH N++ +GY Sbjct: 27 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 86 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 D+ + ++ + G +L + + + TK L IA A+ + YLH I+ Sbjct: 87 MTKDN-LAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYLH---AKNII 140 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+K +NI L T + DF ++ K+ W P VL ++APE Sbjct: 141 HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL--WMAPE 190
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/176 (26%), Positives = 87/176 (49%), Gaps = 10/176 (5%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGI------QQFQAEVKTLGRCRHDNLVTL 269 +G G +G Y + G L+A+K++A+ + ++ Q EV L +H N+V Sbjct: 1067 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAY 1126 Query: 270 IGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPR 449 +G L ++ + + F+PGG++ I P+ + K + + +AYLH+NCV Sbjct: 1127 LGTCLQENTVSIFMEFVPGGSISSIINR--FGPLPEMVFCKYTKQILQGVAYLHENCV-- 1182 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVS-KTTWEFRNSCNHPVSRVLLG---YVAPE 605 +HRD+K +N++L L DF + + W N + + + + G ++APE Sbjct: 1183 -VHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPE 1237
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 70.5 bits (171), Expect = 4e-12 Identities = 53/181 (29%), Positives = 84/181 (46%), Gaps = 7/181 (3%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQG---IQQFQAEVKTLGRCRH 251 G+F IG G FGA + I G VAIK L GR +G + + + E+ L + H Sbjct: 22 GNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTH 81 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH 431 ++ L + S++FL+ + GG L +I + PI R + + ++Y H Sbjct: 82 PHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPI--RESRRYFQQIISGVSYCH 139 Query: 432 DNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWE---FRNSCNHPVSRVLLGYVAP 602 ++ I+HRD+KP N+LLD ++DF +S + +C P Y AP Sbjct: 140 NHM---IVHRDLKPENLLLDANKNIKIADFGLSNYMTDGDLLSTACGSP------NYAAP 190 Query: 603 E 605 E Sbjct: 191 E 191
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 70.1 bits (170), Expect = 5e-12 Identities = 45/149 (30%), Positives = 74/149 (49%), Gaps = 1/149 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG K A G ++ +K L + + F EVK + H N++ IG Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 D ++ L+ ++ GG L+ F+ R+ P W+ + A +A +AYLH C I+HRD Sbjct: 397 KDKKLNLLTEYIEGGTLKDFL--RSMDPFPWQQKVRFAKGIASGMAYLHSMC---IIHRD 451 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 + N L+ + T ++DF +S+ E R Sbjct: 452 LNSHNCLIKLDKTVVVADFGLSRLIVEER 480
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.1 bits (170), Expect = 5e-12 Identities = 52/172 (30%), Positives = 82/172 (47%), Gaps = 3/172 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S IGSG FG YK + + V I ++ + Q F+ EV L + RH N++ +GY Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 D+ + ++ + G +L + + + TK L IA A+ + YLH I+ Sbjct: 412 MTKDN-LAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYLH---AKNII 465 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+K +NI L T + DF ++ K+ W P VL ++APE Sbjct: 466 HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL--WMAPE 515
>M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein) Length = 821 Score = 70.1 bits (170), Expect = 5e-12 Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G+G +G YKA + L A+K + + I Q E+ L CRH N+V IG +L Sbjct: 22 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYL 81 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + +++ F GG+L+ P++ R + + + + L +LH +HRD Sbjct: 82 RNDRLWICMEFCGGGSLQEIY--HATGPLEERQIAYVCREALKGLHHLHSQ---GKIHRD 136 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +N+LL + L+DF VS Sbjct: 137 IKGANLLLTLQGDVKLADFGVS 158
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 70.1 bits (170), Expect = 5e-12 Identities = 44/148 (29%), Positives = 74/148 (50%), Gaps = 4/148 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAP-GILVAIKRLA---IGRFQGIQQFQAEVKTLGRCRHDN 257 F +G G FG Y + G++ A+K + I ++ +QF+ EV+ G +H N Sbjct: 100 FEIGKILGKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGSFKHKN 159 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 L L G+ + ++L+ ++ G L +F+ + P++ + +A AL Y+H Sbjct: 160 LTQLYGFFYDEKRVYLLMEYVYYGELYKFL--KNNGPLNETLASYFVYQMANALDYMHSK 217 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDF 521 ILHRD+KP NIL+ T L+DF Sbjct: 218 ---NILHRDIKPENILIGFNNTIKLTDF 242
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 69.7 bits (169), Expect = 6e-12 Identities = 47/143 (32%), Positives = 79/143 (55%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G K + P G+++A K + + I+ Q E++ L C +V G Sbjct: 78 LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 137 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ ++E + P + +L K+++ V R LAYL + +I+HR Sbjct: 138 YSDGEISICMEHMDGGSLDQVLKEAKRIPEE--ILGKVSIAVLRGLAYLREK--HQIMHR 193 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 194 DVKPSNILVNSRGEIKLCDFGVS 216
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 69.7 bits (169), Expect = 6e-12 Identities = 47/143 (32%), Positives = 79/143 (55%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G K + P G+++A K + + I+ Q E++ L C +V G Sbjct: 76 LGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 135 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ ++E + P + +L K+++ V R LAYL + +I+HR Sbjct: 136 YSDGEISICMEHMDGGSLDQVLKEAKRIPEE--ILGKVSIAVLRGLAYLREK--HQIMHR 191 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 192 DVKPSNILVNSRGEIKLCDFGVS 214
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 69.7 bits (169), Expect = 6e-12 Identities = 44/130 (33%), Positives = 61/130 (46%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 +G G +G KA + LVA+K Q + + EVK L R +H N++ L G Sbjct: 25 VGHGSYGVVCKA-VWRDKLVAVKEFFASAEQ--KDIEKEVKQLSRVKHPNIIALHGISSY 81 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 +LI F GG+L F+ + K A A LAYLH ++HRDV Sbjct: 82 QQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDV 141 Query: 468 KPSNILLDNE 497 KP N+LL N+ Sbjct: 142 KPLNLLLTNK 151
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 69.7 bits (169), Expect = 6e-12 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 3/172 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S IGSG FG YK + + V I ++ + Q F+ EV L + RH N++ +GY Sbjct: 85 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 144 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 D+ + ++ + G +L + + + TK L IA A+ + YLH I+ Sbjct: 145 MTKDN-LAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYLH---AKNII 198 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+K +NI L T + DF ++ K+ W P +L ++APE Sbjct: 199 HRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQPTGSIL--WMAPE 248
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 69.7 bits (169), Expect = 6e-12 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 3/172 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S IGSG FG YK + + V I ++ + Q F+ EV L + RH N++ +GY Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 D+ + ++ + G +L + + + TK L IA A+ + YLH I+ Sbjct: 412 MTKDN-LAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYLH---AKNII 465 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+K +NI L T + DF ++ K+ W P +L ++APE Sbjct: 466 HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSIL--WMAPE 515
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 69.3 bits (168), Expect = 8e-12 Identities = 44/149 (29%), Positives = 76/149 (51%), Gaps = 7/149 (4%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-----GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLI 272 +G G FG+ P G +VA+K+L + ++ F+ E++ L +HDN+V Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 273 G--YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 G Y + LI +LP G+L ++Q+ +R ID + L + + + + YL Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKER-IDHKKLLQYTSQICKGMEYLGTK--- 970 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R +HRD+ NIL++NE + DF ++K Sbjct: 971 RYIHRDLATRNILVENENRVKIGDFGLTK 999
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 69.3 bits (168), Expect = 8e-12 Identities = 49/150 (32%), Positives = 75/150 (50%), Gaps = 4/150 (2%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKA-EIAPGILVAIKRL---AIGRFQGIQQFQAEVKTLGRCRH 251 G F +G G FG Y A E G +VA+K L + + + +Q + E++ RH Sbjct: 87 GMFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRH 146 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH 431 N++ L G+ + ++LI F G L + ++ R KR + K +A AL+YLH Sbjct: 147 KNILRLYGHFHDEKRIYLILEFAGRGELYQHLR-RAKR-FSEEVASKYIFQMANALSYLH 204 Query: 432 DNCVPRILHRDVKPSNILLDNEYTAYLSDF 521 ++HRD+KP NILL + LSDF Sbjct: 205 KK---HVIHRDIKPENILLGIDGEIKLSDF 231
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 69.3 bits (168), Expect = 8e-12 Identities = 45/149 (30%), Positives = 73/149 (48%), Gaps = 1/149 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG K A G ++ +K L + + F EVK + H N++ IG Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 D ++ L+ ++ GG L+ F+ R P W+ + A +A +AYLH C I+HRD Sbjct: 397 KDKKLNLLTEYIEGGTLKDFL--RNVDPFPWQQKVRFAKGIASGMAYLHSMC---IIHRD 451 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 + N L+ + T ++DF +S+ E R Sbjct: 452 LNSHNCLIKLDKTVVVADFGLSRLIVEER 480
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 69.3 bits (168), Expect = 8e-12 Identities = 44/149 (29%), Positives = 76/149 (51%), Gaps = 7/149 (4%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-----GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLI 272 +G G FG+ P G +VA+K+L + ++ F+ E++ L +HDN+V Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 273 G--YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 G Y + LI +LP G+L ++Q+ +R ID + L + + + + YL Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKER-IDHKKLLQYTSQICKGMEYLGTK--- 970 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R +HRD+ NIL++NE + DF ++K Sbjct: 971 RYIHRDLATRNILVENENRVKIGDFGLTK 999
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 69.3 bits (168), Expect = 8e-12 Identities = 47/148 (31%), Positives = 76/148 (51%), Gaps = 4/148 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRCRHDN 257 F +G G FG Y A E ++A+K L + + G++ Q + EV+ RH N Sbjct: 140 FEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPN 199 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L GY S ++LI ++ PGG L R +Q+ T+ D + +A AL Y H Sbjct: 200 ILRLYGYFHDASRVYLILDYAPGGELFRELQKCTR--FDDQRSAMYIKQLAEALLYCHSK 257 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDF 521 +++HRD+KP N+LL + ++DF Sbjct: 258 ---KVIHRDIKPENLLLGSNGELKIADF 282
>M4K2_HUMAN (Q12851) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-pro Length = 819 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G+G +G YKA + L A+K + + I Q E+ L CRH N+V IG +L Sbjct: 21 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYL 80 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + +++ F GG+L+ P++ R + + + + L +LH +HRD Sbjct: 81 RNDRLWICMEFCGGGSLQEIY--HATGPLEERQIAYVCRERLKGLHHLHSQ---GKIHRD 135 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +N+LL + L+DF VS Sbjct: 136 IKGANLLLTLQGDVKLADFGVS 157
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 68.9 bits (167), Expect = 1e-11 Identities = 47/148 (31%), Positives = 76/148 (51%), Gaps = 4/148 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRCRHDN 257 F +G G FG Y A E ++A+K L + + G++ Q + EV+ RH N Sbjct: 140 FEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPN 199 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L GY S ++LI ++ PGG L R +Q+ T+ D + +A AL Y H Sbjct: 200 ILRLYGYFHDASRVYLILDYAPGGELFRELQKCTR--FDDQRSALYIKQLAEALLYCHSK 257 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDF 521 +++HRD+KP N+LL + ++DF Sbjct: 258 ---KVIHRDIKPENLLLGSNGELKIADF 282
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/144 (31%), Positives = 73/144 (50%), Gaps = 2/144 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YK + VA+K Q ++ +F E K L + H N+V LIG Sbjct: 70 LGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 129 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH-DNCVPRILHR 461 +++I +PGG+ F+++R K + + L + +LDVA + YL NC+ HR Sbjct: 130 QRQPVYIIMELVPGGDFLSFLRKR-KDELKLKQLVRFSLDVAAGMLYLEGKNCI----HR 184 Query: 462 DVKPSNILLDNEYTAYLSDFWVSK 533 D+ N L+ T +SDF +S+ Sbjct: 185 DLAARNCLVGENNTLKISDFGMSR 208
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 68.9 bits (167), Expect = 1e-11 Identities = 53/201 (26%), Positives = 96/201 (47%), Gaps = 14/201 (6%) Frame = +3 Query: 45 GAPLTYETVVRAAGS------FNASNCIGSGGFGATYKA---EIAPGILVAIKRLAIGRF 197 G P +Y + A S F+ + IG+G F YK + +++ + +L R Sbjct: 36 GRPSSYRVLRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRG 95 Query: 198 QGIQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDW 377 ++ EV+ + R RH N++ +G + ++ + ++ GG LE+ + + P+ W Sbjct: 96 NTLR----EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLS--SPEPLSW 149 Query: 378 RMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILL---DNEYTAYLSDFWVSKTTWEF 548 + +ALD+AR L YLH + HRD+ N L+ D +TA + DF +++ + Sbjct: 150 PVRLHLALDIARGLRYLHSK---GVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVY 206 Query: 549 RNSC-NHPVSRVLLGY-VAPE 605 R P++ V Y +APE Sbjct: 207 REGARKEPLAVVGSPYWMAPE 227
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 68.9 bits (167), Expect = 1e-11 Identities = 52/181 (28%), Positives = 86/181 (47%), Gaps = 7/181 (3%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAE-IAPGILVAIKRL---AIGRFQGIQQFQAEVKTLGRCRHDN 257 F N +G G F Y+AE I G+ VAIK + A+ + +Q+ Q EVK + +H + Sbjct: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L Y ++ ++L+ G + R+++ R K P R + + YLH + Sbjct: 72 VLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMK-PFSEREARHFMHQIITGMLYLHSH 130 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YVAPEY 608 ILHRD+ SNILL ++DF ++ + + H L G Y++PE Sbjct: 131 ---GILHRDLTLSNILLTRNMNIKIADFGLAT-----QLNMPHEKHYTLCGTPNYISPEI 182 Query: 609 A 611 A Sbjct: 183 A 183
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 68.9 bits (167), Expect = 1e-11 Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 1/149 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG K A G ++ +K L + + F EVK + H N++ IG Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 D ++ L+ ++ GG L+ F+ R P W+ A +A +AYLH C I+HRD Sbjct: 397 KDKKLNLLTEYIEGGTLKDFL--RNADPFPWQQKVSFAKGIASGMAYLHSMC---IIHRD 451 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 + N L+ + T ++DF +S+ E R Sbjct: 452 LNSHNCLIKLDKTVVVADFGLSRLIVEER 480
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 68.6 bits (166), Expect = 1e-11 Identities = 48/175 (27%), Positives = 85/175 (48%), Gaps = 9/175 (5%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRF--QGIQQFQAEVKTLGRCRHDNLVTLIGY 278 +G G +G Y AE + G L K + + + + + Q+E+K L C H N++ I Sbjct: 26 VGLGSYGEAYVAESVEDGSLCVAKVMDLSKMSQRDKRYAQSEIKCLANCNHPNIIRYIED 85 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHK---IALDVARALAYLHDNCVPR 449 H + + ++ F GNL+ I+ R + H+ + L + AL Y+H + + Sbjct: 86 HEENDRLLIVMEFADSGNLDEQIKLRGSGDARYFQEHEALFLFLQLCLALDYIHSH---K 142 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YVAPE 605 +LHRD+K +N+LL + L DF S ++ ++ + V+ G Y+APE Sbjct: 143 MLHRDIKSANVLLTSTGLVKLGDFGFSH---QYEDTVSGVVASTFCGTPYYLAPE 194
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 68.6 bits (166), Expect = 1e-11 Identities = 44/149 (29%), Positives = 74/149 (49%), Gaps = 1/149 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG K A G ++ +K L + + F EVK + H N++ IG Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 D ++ L+ ++ GG L+ F+ R+ P W+ + A ++ +AYLH C I+HRD Sbjct: 397 KDKKLNLLTEYIEGGTLKDFL--RSVDPFPWQQKVRFAKGISSGMAYLHSMC---IIHRD 451 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 + N L+ + T ++DF +S+ E R Sbjct: 452 LNSHNCLIKLDKTVVVADFGLSRLIVEER 480
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 68.6 bits (166), Expect = 1e-11 Identities = 45/143 (31%), Positives = 74/143 (51%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGI--QQFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P LV ++L + Q E++ L C +V G Sbjct: 75 LGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 134 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ ++E + P + +L K+++ V R L YL + +I+HR Sbjct: 135 YSDGEISICMEHMDGGSLDQVLKEARRIPEE--ILGKVSIAVLRGLVYLREK--HQIMHR 190 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 191 DVKPSNILVNSRGEIKLCDFGVS 213
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 68.6 bits (166), Expect = 1e-11 Identities = 48/185 (25%), Positives = 92/185 (49%), Gaps = 6/185 (3%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRH 251 A F +G+G + YK G+ VA+K + + +G E+ + +H Sbjct: 3 APSQFKQLEKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTK----RPIDWRMLHKIALDVARAL 419 DN+V L +++++ L++ F+ +L++F+ R K + ++ ++ + + + Sbjct: 63 DNIVRLFDVIHTENKLTLVFEFMDN-DLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGV 121 Query: 420 AYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVA 599 A+ H+N RILHRD+KP N+L++N L DF +++ N+ + V V L Y A Sbjct: 122 AFCHEN---RILHRDLKPQNLLINNRGQLKLGDFGLARAFGIPVNTFSSEV--VTLWYRA 176 Query: 600 PEYAM 614 P+ M Sbjct: 177 PDVLM 181
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/140 (30%), Positives = 73/140 (52%), Gaps = 2/140 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ--QFQAEVKTLGRCRHDNLVTLIGYH 281 IG G +G + + G+ VA+K+ + Q +F+AE+ L +H N+VT IG Sbjct: 1370 IGLGSYGIVFNGKWK-GVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGAC 1428 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 + + ++ ++ GNL R + + I + K+ A + YLH + P I+HR Sbjct: 1429 IKKPNICIVTEYMRMGNL-RDVLKNPDIKITFANKLKLLYGAAMGIDYLHSSN-PMIVHR 1486 Query: 462 DVKPSNILLDNEYTAYLSDF 521 D+KP+NIL+D + ++DF Sbjct: 1487 DIKPANILVDEHFNVKIADF 1506 Score = 66.2 bits (160), Expect = 7e-11 Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 2/168 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQ--FQAEVKTLGRCRHDNLVTLIGYH 281 +G+GG+G YK+ I G VA+K ++ + F EVK + RH N+V + Sbjct: 792 LGTGGYGEVYKS-IWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 M ++ F+ G+L + I + + K+A ++ + +LH + I+HR Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSS---GIVHR 907 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 D+K N+LLD+++ +SDF ++K E + + ++APE Sbjct: 908 DLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPE 955
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/147 (33%), Positives = 76/147 (51%), Gaps = 6/147 (4%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G GGFG ++A VA+K + ++ EVK + R++N++ L+G Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIV------NSKKISWEVKAMVNLRNENVLLLLGVTE 81 Query: 285 S-----DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPR 449 S L+ F+ G+L +Q RP W +L ++ +V + YLH + P Sbjct: 82 DLQWDFVSGQALVTRFMENGSLAGLLQPECPRP--WPLLCRLLQEVVLGMCYLH-SLDPP 138 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVS 530 +LHRD+KPSNILLD E A L+DF +S Sbjct: 139 LLHRDLKPSNILLDPELHAKLADFGLS 165
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 68.2 bits (165), Expect = 2e-11 Identities = 51/176 (28%), Positives = 89/176 (50%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEI-APGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 SF IG G +G YKA+ G VA+K++ + +G+ E+ L H N Sbjct: 3 SFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L ++++++L++ FL +L+RF+ T I ++ + + LA+ H + Sbjct: 63 IVKLHDVIHTENKLYLVFEFLHQ-DLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ + L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 68.2 bits (165), Expect = 2e-11 Identities = 51/169 (30%), Positives = 81/169 (47%), Gaps = 4/169 (2%) Frame = +3 Query: 45 GAPLTYETVVRAAGSFNASNCIGSGGFGATYKAE-IAPGILVAIKRLA---IGRFQGIQQ 212 G PL+ ++ A F +G G FG Y I G + A+K + I ++ +Q Sbjct: 95 GVPLSKLQNLKLA-DFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQ 153 Query: 213 FQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHK 392 F+ EV+ RH NL L GY + ++L+ +L G L + ++ R+ + + Sbjct: 154 FRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSH--FNDVVASY 211 Query: 393 IALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTT 539 +A AL Y+H+ ILHRD+KP NI++ T L+DF S T Sbjct: 212 YVYQMADALDYMHER---NILHRDIKPENIIIGFNNTIKLTDFGWSVIT 257
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 67.8 bits (164), Expect = 2e-11 Identities = 48/176 (27%), Positives = 90/176 (51%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIAP-GILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ FL +L++F+ I ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFEFL-NQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++++ L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINSDGAIKLADFGLARAFGVPVRTFTHEV--VTLWYRAPE 172
>AVR2A_RAT (P38444) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 67.8 bits (164), Expect = 2e-11 Identities = 51/146 (34%), Positives = 73/146 (50%), Gaps = 11/146 (7%) Frame = +3 Query: 117 GGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS--- 287 G FG +KA++ VA+K I Q Q + EV +L +H+N++ IG Sbjct: 201 GRFGCVWKAQLL-NEYVAVKIFPIQDKQSWQN-EYEVYSLPGMKHENILQFIGAEKRGTS 258 Query: 288 -DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH-------DNCV 443 D +++LI F G+L F++ + W L IA +AR LAYLH D Sbjct: 259 VDVDLWLITAFHEKGSLSDFLKANV---VSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDF 521 P I HRD+K N+LL N TA ++DF Sbjct: 316 PAISHRDIKSKNVLLKNNLTACIADF 341
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 67.8 bits (164), Expect = 2e-11 Identities = 51/146 (34%), Positives = 73/146 (50%), Gaps = 11/146 (7%) Frame = +3 Query: 117 GGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS--- 287 G FG +KA++ VA+K I Q Q + EV +L +H+N++ IG Sbjct: 201 GRFGCVWKAQLL-NEYVAVKIFPIQDKQSWQN-EYEVYSLPGMKHENILQFIGAEKRGTS 258 Query: 288 -DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH-------DNCV 443 D +++LI F G+L F++ + W L IA +AR LAYLH D Sbjct: 259 VDVDLWLITAFHEKGSLSDFLKANV---VSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDF 521 P I HRD+K N+LL N TA ++DF Sbjct: 316 PAISHRDIKSKNVLLKNNLTACIADF 341
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 67.8 bits (164), Expect = 2e-11 Identities = 51/146 (34%), Positives = 73/146 (50%), Gaps = 11/146 (7%) Frame = +3 Query: 117 GGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS--- 287 G FG +KA++ VA+K I Q Q + EV +L +H+N++ IG Sbjct: 201 GRFGCVWKAQLL-NEYVAVKIFPIQDKQSWQN-EYEVYSLPGMKHENILQFIGAEKRGTS 258 Query: 288 -DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH-------DNCV 443 D +++LI F G+L F++ + W L IA +AR LAYLH D Sbjct: 259 VDVDLWLITAFHEKGSLSDFLKANV---VSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDF 521 P I HRD+K N+LL N TA ++DF Sbjct: 316 PAISHRDIKSKNVLLKNNLTACIADF 341
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 67.8 bits (164), Expect = 2e-11 Identities = 51/146 (34%), Positives = 73/146 (50%), Gaps = 11/146 (7%) Frame = +3 Query: 117 GGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS--- 287 G FG +KA++ VA+K I Q Q + EV +L +H+N++ IG Sbjct: 201 GRFGCVWKAQLL-NEYVAVKIFPIQDKQSWQN-EYEVYSLPGMKHENILQFIGAEKRGTS 258 Query: 288 -DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH-------DNCV 443 D +++LI F G+L F++ + W L IA +AR LAYLH D Sbjct: 259 VDVDLWLITAFHEKGSLSDFLKANV---VSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDF 521 P I HRD+K N+LL N TA ++DF Sbjct: 316 PAISHRDIKSKNVLLKNNLTACIADF 341
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 9/155 (5%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIG-------RFQG-IQQFQAEVKTLGRCRHDNL 260 IG G FG Y + G L+AIK++ I + QG I++ + EV+ L H N+ Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNI 133 Query: 261 VTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 V +G + ++ F+PGG++ +++ P +++ L + L YLH+N Sbjct: 134 VRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLG--LEYLHNN- 190 Query: 441 VPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWE 545 I+HRD+K +NIL+DN+ L+DF SK E Sbjct: 191 --GIMHRDIKGANILVDNKGCIRLADFGASKKVVE 223
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/176 (27%), Positives = 89/176 (50%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ FL +L++F+ I ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ E L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/176 (27%), Positives = 91/176 (51%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA+ G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ FL +L++F+ I ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ E + L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 67.8 bits (164), Expect = 2e-11 Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 7/134 (5%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQ----FQAEVKTLGRCRHDNLVTLIG 275 IG GGFG Y+A G VA+K + I Q + E K +H N++ L G Sbjct: 150 IGIGGFGKVYRA-FWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRG 208 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRP---IDWRMLHKIALDVARALAYLHDNCVP 446 L + + L+ F GG L R + + P ++W A+ +AR + YLHD + Sbjct: 209 VCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNW------AVQIARGMNYLHDEAIV 262 Query: 447 RILHRDVKPSNILL 488 I+HRD+K SNIL+ Sbjct: 263 PIIHRDLKSSNILI 276
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/176 (27%), Positives = 91/176 (51%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA+ G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ FL +L++F+ I ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ E + L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 67.4 bits (163), Expect = 3e-11 Identities = 49/170 (28%), Positives = 88/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK A G +VA+K++ + +G+ E+ L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQE-RTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ + + ID ++ + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ L+DF +++ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEV--VTLWYRAPE 173
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 67.4 bits (163), Expect = 3e-11 Identities = 49/166 (29%), Positives = 82/166 (49%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FGA + E G VA+K + Q F E + + +H+NLV L+G L Sbjct: 241 IGEGEFGAVLQGEYL-GQKVAVKNIKCD--VTAQAFLDETAVMTKMQHENLVRLLGVILH 297 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 ++++ + GNL F++ R + ++ L + +L VA + YL +++HRD+ Sbjct: 298 QG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESK---KLVHRDL 353 Query: 468 KPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 NIL+ + A +SDF ++K + +S PV + APE Sbjct: 354 AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK-----WTAPE 394
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 67.4 bits (163), Expect = 3e-11 Identities = 52/201 (25%), Positives = 96/201 (47%), Gaps = 14/201 (6%) Frame = +3 Query: 45 GAPLTYETVVRAAGS------FNASNCIGSGGFGATYKA---EIAPGILVAIKRLAIGRF 197 G P +Y + A S F+ + IG+G F YK + +++ + +L R Sbjct: 31 GRPSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRS 90 Query: 198 QGIQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDW 377 ++ EV+ + R RH N++ +G + ++ + ++ GG LE+ + + P+ W Sbjct: 91 NTLR----EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLS--SPEPLSW 144 Query: 378 RMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILL---DNEYTAYLSDFWVSKTTWEF 548 + +ALD+A+ L YLH + HRD+ N L+ D +TA + DF +++ + Sbjct: 145 PVRLHLALDIAQGLRYLH---AKGVFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVY 201 Query: 549 RNSC-NHPVSRVLLGY-VAPE 605 R P++ V Y +APE Sbjct: 202 REGARKEPLAVVGSPYWMAPE 222
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 67.4 bits (163), Expect = 3e-11 Identities = 44/149 (29%), Positives = 75/149 (50%), Gaps = 7/149 (4%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-----GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLI 272 +G G FG+ P G +VA+K+L + ++ F+ E++ L +HDN+V Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 273 G--YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 G Y + LI +LP G+L ++Q+ +R ID L + + + + YL Sbjct: 915 GVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER-IDHIKLLQYTSQICKGMEYLGTK--- 970 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R +HRD+ NIL++NE + DF ++K Sbjct: 971 RYIHRDLATRNILVENENRVKIGDFGLTK 999
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 67.0 bits (162), Expect = 4e-11 Identities = 44/179 (24%), Positives = 95/179 (53%), Gaps = 3/179 (1%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKAEI-APGILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRH 251 ++ F +G G + YK A G LVA+K +++ +G E+ + H Sbjct: 4 SSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKELDH 63 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIALDVARALAYL 428 +N+VTL +++++ L++ ++ +L+++++ ++ +D +++ + + + + Sbjct: 64 ENIVTLYDVIHTENKLTLVFEYMDK-DLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFC 122 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HDN R+LHRD+KP N+L++N+ L DF +++ N+ ++ V V L Y AP+ Sbjct: 123 HDN---RVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEV--VTLWYRAPD 176
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 67.0 bits (162), Expect = 4e-11 Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 4/152 (2%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRC 245 A F +G G FG Y A E ++A+K L + + G++ Q + EV+ Sbjct: 129 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188 Query: 246 RHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAY 425 RH N++ L GY + ++LI + P G + R +Q+ +K D + ++A AL+Y Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSY 246 Query: 426 LHDNCVPRILHRDVKPSNILLDNEYTAYLSDF 521 H R++HRD+KP N+LL + ++DF Sbjct: 247 CHSK---RVIHRDIKPENLLLGSAGELKIADF 275
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 67.0 bits (162), Expect = 4e-11 Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 3/169 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IGSG FG Y+A + V + +Q F+ EV L + RH N++ +G +S Sbjct: 435 IGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGC-VS 493 Query: 288 DSEMFLIYNFLPGGNLERFIQ-ERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + ++ + G +L + + TK ++ L I VA+ + YLH I+HRD Sbjct: 494 KPSLAIVTQWCEGSSLYKHVHVSETKFKLN--TLIDIGRQVAQGMDYLH---AKNIIHRD 548 Query: 465 VKPSNILLDNEYTAYLSDFWV--SKTTWEFRNSCNHPVSRVLLGYVAPE 605 +K +NI L + + + DF + +KT W N P +L ++APE Sbjct: 549 LKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSIL--WMAPE 595
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 67.0 bits (162), Expect = 4e-11 Identities = 46/161 (28%), Positives = 76/161 (47%), Gaps = 3/161 (1%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGI--QQFQAEVK 230 + TV + N +G G FG A + G VA+K++ + ++ E+K Sbjct: 13 FGTVFEITNRYTDLNPVGMGAFGLVCSAIDKLTGQNVAVKKIMKPFLTSVLAKRTYRELK 72 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVA 410 L RH+NL+TL LS E L G +L R + T RP++ + + + Sbjct: 73 LLKHLRHENLITLDDIFLSPLEDIYFVTELQGTDLHRLL---TSRPLEKQFIQYFTYQIL 129 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R L Y+H ++HRD+KPSNIL++ + DF +++ Sbjct: 130 RGLKYVHS---AGVIHRDLKPSNILINENCDLKICDFGLAR 167
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 67.0 bits (162), Expect = 4e-11 Identities = 48/176 (27%), Positives = 91/176 (51%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA+ G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ FL +L++F+ + ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGLPLPLIKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ E + L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 67.0 bits (162), Expect = 4e-11 Identities = 51/174 (29%), Positives = 95/174 (54%), Gaps = 8/174 (4%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGI---LVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTL 269 +G G +G YKA ++ PG +VA+K++ + +G+ E+ L + DN+V L Sbjct: 14 VGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRL 73 Query: 270 IGYHLSDS-EMFLIYNFLPGGNLERFIQERTK-RPIDWRMLHKIALDVARALAYLHDNCV 443 SD+ +++L++ FL +L+R+++ K +P+ ++ K + + + +AY H + Sbjct: 74 YDIVHSDAHKLYLVFEFLDL-DLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSH-- 130 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RILHRD+KP N+L++ + L DF +++ + H + V L Y APE Sbjct: 131 -RILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEI--VTLWYRAPE 181
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 67.0 bits (162), Expect = 4e-11 Identities = 52/201 (25%), Positives = 96/201 (47%), Gaps = 14/201 (6%) Frame = +3 Query: 45 GAPLTYETVVRAAGS------FNASNCIGSGGFGATYKA---EIAPGILVAIKRLAIGRF 197 G P +Y + A S F+ + IG+G F YK + +++ + +L R Sbjct: 31 GRPSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRS 90 Query: 198 QGIQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDW 377 ++ EV+ + R RH N++ +G + ++ + ++ GG LE+ + + P+ W Sbjct: 91 NTLR----EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLS--SPEPLSW 144 Query: 378 RMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILL---DNEYTAYLSDFWVSKTTWEF 548 + +ALD+A+ L YLH + HRD+ N L+ D +TA + DF +++ + Sbjct: 145 PVRLHLALDIAQGLRYLH---AKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVY 201 Query: 549 RNSC-NHPVSRVLLGY-VAPE 605 R P++ V Y +APE Sbjct: 202 REGTRKEPLAVVGSPYWMAPE 222
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 66.6 bits (161), Expect = 5e-11 Identities = 43/143 (30%), Positives = 74/143 (51%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGI--QQFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P L+ ++L + Q E++ L C +V G Sbjct: 73 LGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 132 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ K P ++L K+++ V + L YL + +I+HR Sbjct: 133 YSDGEISICMEHMDGGSLDQVLKKAGKIPE--KILGKVSIAVIKGLTYLREK--HKIMHR 188 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 189 DVKPSNILVNSRGEIKLCDFGVS 211
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 66.6 bits (161), Expect = 5e-11 Identities = 51/166 (30%), Positives = 82/166 (49%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FGA + E G VA+K + Q F E + + +H NLV L+G L Sbjct: 200 IGEGEFGAVLQGEYL-GQKVAVKNIKCD--VTAQAFLDETAVMTKLQHRNLVRLLGVILH 256 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 ++++ + GNL F++ R + + L + AL VA + YL +++HRD+ Sbjct: 257 HG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESK---KLVHRDL 312 Query: 468 KPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 NIL+ + A +SDF ++K E R + SR+ + + APE Sbjct: 313 AARNILVSEDLVAKVSDFGLAKA--ELRKGLDS--SRLPVKWTAPE 354
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 66.6 bits (161), Expect = 5e-11 Identities = 48/176 (27%), Positives = 91/176 (51%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA+ G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ FL +L++F+ I ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ + + L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINADGSIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Length = 847 Score = 66.2 bits (160), Expect = 7e-11 Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +GSG +G YKA + G L A+K + + Q E+ + C+H N+V G +L Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYL 85 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 S ++++ + GG+L+ P+ + + + + LAYLH +HRD Sbjct: 86 SREKLWICMEYCGGGSLQDIY--HVTGPLSEMQIAYVCRETLQGLAYLH---TKGKMHRD 140 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +NILL + L+DF V+ Sbjct: 141 IKGANILLTDHGDVKLADFGVA 162
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 66.2 bits (160), Expect = 7e-11 Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 3/153 (1%) Frame = +3 Query: 81 AGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRF--QGIQQFQAEVKTLGRCRH 251 A S +C+G G FGA Y+ I G VA+K++ + + + + E+ L H Sbjct: 6 ASSITLGDCLGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDH 65 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLH 431 N+V G + ++ + +I + G+L + K P + L+ V + L YLH Sbjct: 66 PNIVKYRGSYQTNDSLCIILEYCENGSLRSICKNFGKIPENLVALY--TFQVLQGLLYLH 123 Query: 432 DNCVPRILHRDVKPSNILLDNEYTAYLSDFWVS 530 + V +HRD+K +NIL + T L+DF V+ Sbjct: 124 NQGV---IHRDIKGANILTTKDGTIKLADFGVA 153
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 66.2 bits (160), Expect = 7e-11 Identities = 44/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGVF 133 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 189 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 190 DVKPSNILVNSRGEIKLCDFGVS 212
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 66.2 bits (160), Expect = 7e-11 Identities = 50/166 (30%), Positives = 80/166 (48%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FGA + E G VA+K + Q F E + + +H NLV L+G L Sbjct: 239 IGEGEFGAVLQGEYL-GQKVAVKNIKCD--VTAQAFLDETAVMTKLQHRNLVRLLGVILH 295 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 ++++ + GNL F++ R + + L + AL VA + YL +++HRD+ Sbjct: 296 HG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESK---KLVHRDL 351 Query: 468 KPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 NIL+ + A +SDF ++K + +S PV + APE Sbjct: 352 AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK-----WTAPE 392
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 66.2 bits (160), Expect = 7e-11 Identities = 42/153 (27%), Positives = 82/153 (53%), Gaps = 11/153 (7%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAI-----GRFQGIQQ-----FQAEVKTLGRCRHD 254 IG+G +G + A I G L+A+K++ I GR +++ AE+ + H Sbjct: 831 IGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDHL 890 Query: 255 NLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHD 434 N+V +G+ +++++ + ++ GG++ R + R P + +++ ++ V L+YLH Sbjct: 891 NIVQYLGFEKTETDISIFLEYVSGGSIGRCL--RNYGPFEEQLVRFVSRQVLYGLSYLHS 948 Query: 435 NCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 I+HRD+K N+L+D + +SDF +SK Sbjct: 949 K---GIIHRDLKADNLLIDFDGVCKISDFGISK 978
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 66.2 bits (160), Expect = 7e-11 Identities = 44/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 67 LGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 126 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 127 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 182 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 183 DVKPSNILVNSRGEIKLCDFGVS 205
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 66.2 bits (160), Expect = 7e-11 Identities = 45/148 (30%), Positives = 77/148 (52%), Gaps = 4/148 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRCRHDN 257 F+ +G G FG Y A E ++A+K L + + G++ Q + EV+ RH N Sbjct: 126 FDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPN 185 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L GY + ++LI + P G + R +Q+ +K D + ++A AL+Y H Sbjct: 186 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSK 243 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDF 521 R++HRD+KP N+LL + ++DF Sbjct: 244 ---RVIHRDIKPENLLLGSNGELKIADF 268
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 66.2 bits (160), Expect = 7e-11 Identities = 50/181 (27%), Positives = 83/181 (45%), Gaps = 7/181 (3%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAE-IAPGILVAIKRL---AIGRFQGIQQFQAEVKTLGRCRHDN 257 F N +G G F Y+AE I G+ VAIK + A+ + +Q+ Q EVK + +H + Sbjct: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L Y + ++L+ G + R+++ R K P + + YLH + Sbjct: 72 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVK-PFSENEARHFMHQIITGMLYLHSH 130 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YVAPEY 608 ILHRD+ SN+LL ++DF ++ + H L G Y++PE Sbjct: 131 ---GILHRDLTLSNLLLTRNMNIKIADFGLAT-----QLKMPHEKHYTLCGTPNYISPEI 182 Query: 609 A 611 A Sbjct: 183 A 183
>DSOR1_DROME (Q24324) Dual specificity mitogen-activated protein kinase kinase| dSOR1 (EC 2.7.12.2) (Downstream of RAF) (MAPKK) Length = 396 Score = 66.2 bits (160), Expect = 7e-11 Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGI--QQFQAEVKTLGRCRHDNLVTLIGYH 281 +GSG G K L+ ++L + +Q E+K L C ++V G Sbjct: 93 LGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAF 152 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + ++ GG+L+ ++ + P +L +I L V + L+YL DN I+HR Sbjct: 153 YSDGEISICMEYMDGGSLDLILKRAGRIPES--ILGRITLAVLKGLSYLRDNHA--IIHR 208 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ + DF VS Sbjct: 209 DVKPSNILVNSSGEIKICDFGVS 231
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 66.2 bits (160), Expect = 7e-11 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 6/172 (3%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G GFG ++A+ G VA+K + + EVK + ++ ++ L G Sbjct: 27 VGKDGFGTVFRAQHRKWGYDVAVKIV------NSKAISREVKAMASLDNEFVLRLEGVIE 80 Query: 285 S-----DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPR 449 D + L+ F+ G+L +Q + RP W +L ++ +V + YLHD P Sbjct: 81 KVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP--WPLLCRLLKEVVLGMFYLHDQN-PV 137 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 +LHRD+KPSN+L D E L+DF +S ++ LGY+APE Sbjct: 138 LLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPE 189
>M4K5_HUMAN (Q9Y4K4) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS) Length = 846 Score = 65.9 bits (159), Expect = 9e-11 Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +GSG +G YKA + G L A+K + + Q E+ + C+H N+V G +L Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYL 85 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 S ++++ + GG+L+ P+ + + + + LAYLH +HRD Sbjct: 86 SREKLWICMEYCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLH---TKGKMHRD 140 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +NILL + L+DF V+ Sbjct: 141 IKGANILLTDHGDVKLADFGVA 162
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 65.9 bits (159), Expect = 9e-11 Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 2/171 (1%) Frame = +3 Query: 99 SNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 S+ IGSG FG YK + + V I ++ + +Q F+ EV L + RH N++ +GY Sbjct: 343 SSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 402 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 D+ + ++ + G +L + + L IA A+ + YLH I+H Sbjct: 403 MTKDN-LAIVTQWCEGSSLYYHLHVLDTK-FQMFQLIDIARQTAQGMDYLH---AKNIIH 457 Query: 459 RDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+K +NI L T + DF ++ KT W +L ++APE Sbjct: 458 RDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSIL--WMAPE 506
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 65.9 bits (159), Expect = 9e-11 Identities = 44/189 (23%), Positives = 90/189 (47%), Gaps = 2/189 (1%) Frame = +3 Query: 51 PLTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVK 230 P+ ++ + + N IG G FG+ ++A+ VA K L + + ++F E K Sbjct: 207 PVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAER-EKFVLEAK 265 Query: 231 TLGRCRHDNLVTLIGY--HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALD 404 + + RH +V L+G D M +I ++ G+L+ +++ + + + + + Sbjct: 266 IMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAE 325 Query: 405 VARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVL 584 ++ +AYL +++HRD++ NIL+ N+ T ++DF +++ T R Sbjct: 326 ISEGMAYLESE---KVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKTLRFP 382 Query: 585 LGYVAPEYA 611 + APE A Sbjct: 383 YKWTAPEAA 391
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 65.9 bits (159), Expect = 9e-11 Identities = 44/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 73 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 132 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 133 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 188 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 189 DVKPSNILVNSRGEIKLCDFGVS 211
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 65.9 bits (159), Expect = 9e-11 Identities = 44/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 73 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 132 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 133 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 188 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 189 DVKPSNILVNSRGEIKLCDFGVS 211
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 65.9 bits (159), Expect = 9e-11 Identities = 44/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 73 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 132 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 133 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 188 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 189 DVKPSNILVNSRGEIKLCDFGVS 211
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 65.9 bits (159), Expect = 9e-11 Identities = 44/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 73 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 132 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 133 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 188 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DVKPSNIL+++ L DF VS Sbjct: 189 DVKPSNILVNSRGEIKLCDFGVS 211
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 65.9 bits (159), Expect = 9e-11 Identities = 50/177 (28%), Positives = 90/177 (50%), Gaps = 4/177 (2%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDN 257 +F + IG G +G YKA + G VA+K++ + G +G+ E+ L +H N Sbjct: 7 NFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPN 66 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLE-RFIQERTKRPIDWRMLHKIALDVARALAYLHD 434 +V L +S + +++I+ +L N++ + + ++ K +++ + A+ + H Sbjct: 67 VVQLFDVVISGNNLYMIFEYL---NMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHT 123 Query: 435 NCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 N RILHRD+KP N+L+D L+DF +++ + H V V L Y APE Sbjct: 124 N---RILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEV--VTLWYRAPE 175
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 65.9 bits (159), Expect = 9e-11 Identities = 47/158 (29%), Positives = 82/158 (51%), Gaps = 6/158 (3%) Frame = +3 Query: 78 AAGSFNASNC-IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRH 251 AA ++ SN +G GG G Y++E P VAIK L G + +F E +G+ H Sbjct: 717 AAAKWSVSNTTMGRGGGGGGYESE--PYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSH 774 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKR--PIDWRMLHKIALDVARALAY 425 N++ LIG S + ++ ++ G+L++F++ +R + W + ++ +A + Y Sbjct: 775 PNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKY 834 Query: 426 LHD-NCVPRI-LHRDVKPSNILLDNEYTAYLSDFWVSK 533 L D V R+ RD+ N+LLD E ++DF +S+ Sbjct: 835 LTDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSR 872
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 65.9 bits (159), Expect = 9e-11 Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 1/167 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FG + G VA+K I Q F AE + + RH NLV L+G + Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVE 257 Query: 288 D-SEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + S ++++ ++ G+L +++ R + + L K +LDV A+ YL N +HRD Sbjct: 258 EKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEAN---NFVHRD 314 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 + N+L+ + A +SDF ++K +++ PV + APE Sbjct: 315 LAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVK-----WTAPE 356
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 65.5 bits (158), Expect = 1e-10 Identities = 51/185 (27%), Positives = 87/185 (47%), Gaps = 4/185 (2%) Frame = +3 Query: 72 VRAAGSFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAI-GRFQGIQQFQA-EVKTLGR 242 V F IG G +G YK + +VA+K++ + +G+ E+ L Sbjct: 16 VYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKE 75 Query: 243 CRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIALDVARAL 419 +H N+V L + ++ +FLI+ FL +L+R++ + K + L + +A+ Sbjct: 76 LQHPNVVGLEAVIMQENRLFLIFEFL-SFDLKRYMDQLGKDEYLPLETLKSYTFQILQAM 134 Query: 420 AYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVA 599 + H R++HRD+KP N+L+DN L+DF +++ H V V L Y A Sbjct: 135 CFCHQR---RVIHRDLKPQNLLVDNNGAIKLADFGLARAIGIPIRVYTHEV--VTLWYRA 189 Query: 600 PEYAM 614 PE M Sbjct: 190 PEILM 194
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 65.5 bits (158), Expect = 1e-10 Identities = 38/133 (28%), Positives = 72/133 (54%), Gaps = 5/133 (3%) Frame = +3 Query: 222 EVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIA 398 E + L + R ++ ++G + ++ ++P G+L + +T+ P + W + +I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125 Query: 399 LDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK----TTWEFRNSCNH 566 ++A + YLH N P +LH D+K NILLDNE+ ++DF +SK + + R+S + Sbjct: 126 HEIALGVNYLH-NMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSA 184 Query: 567 PVSRVLLGYVAPE 605 P ++ Y+ PE Sbjct: 185 PEGGTII-YMPPE 196
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 65.5 bits (158), Expect = 1e-10 Identities = 59/204 (28%), Positives = 94/204 (46%), Gaps = 13/204 (6%) Frame = +3 Query: 33 FVDIGAPLTYETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQG-- 203 F+ + + + T+ G F + SG FG Y + G L+A+K + + + Sbjct: 1023 FIKLASSFSNITIRWQQGHF-----VRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFR 1077 Query: 204 --IQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDW 377 + Q E+ L R H N+VT G + ++++ F GG+L + R D Sbjct: 1078 STVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHG--RIEDE 1135 Query: 378 RMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDN----EYTAYLSDFWVS-KTTW 542 +L + + LAY+H ILHRD+KP+NILLD+ +Y+ + S +VS T Sbjct: 1136 NVLKVYVVQLLEGLAYIHSQ---HILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDP 1192 Query: 543 EFRNSCNHPVSRVLLG---YVAPE 605 E R P + L G Y+APE Sbjct: 1193 EVRYEDIQPELQHLAGTPMYMAPE 1216
>M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) Length = 894 Score = 65.5 bits (158), Expect = 1e-10 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IGSG +G YKA + G L AIK + + + Q E+ + C+H N+V G +L Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL 81 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++++ F GG+L+ P+ + ++ + + L YLH +HRD Sbjct: 82 RRDKLWICMEFCGGGSLQDIY--HVTGPLSELQIAYVSRETLQGLYYLHSK---GKMHRD 136 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +NILL + L+DF VS Sbjct: 137 IKGANILLTDNGHVKLADFGVS 158
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 65.5 bits (158), Expect = 1e-10 Identities = 44/148 (29%), Positives = 74/148 (50%), Gaps = 4/148 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQ---QFQAEVKTLGRCRHDN 257 F+ +G G FG Y A E ++A+K L + + Q + EV+ RH N Sbjct: 124 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPN 183 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L GY + ++LI + P G + R +Q+ +K D + ++A AL+Y H Sbjct: 184 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSK 241 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDF 521 R++HRD+KP N+LL + ++DF Sbjct: 242 ---RVIHRDIKPENLLLGSNGELKIADF 266
>M4K3_MOUSE (Q99JP0) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragments) Length = 681 Score = 65.5 bits (158), Expect = 1e-10 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IGSG +G YKA + G L AIK + + + Q E+ + C+H N+V G +L Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL 81 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++++ F GG+L+ P+ + ++ + + L YLH +HRD Sbjct: 82 RRDKLWICMEFCGGGSLQDIY--HVTGPLSELQIAYVSRETLQGLYYLHSK---GKMHRD 136 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +NILL + L+DF VS Sbjct: 137 IKGANILLTDNGHVKLADFGVS 158
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 65.5 bits (158), Expect = 1e-10 Identities = 48/176 (27%), Positives = 90/176 (51%), Gaps = 3/176 (1%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDN 257 +F IG G +G YKA+ G +VA+K++ + +G+ E+ L H N Sbjct: 3 NFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 +V L+ ++++++L++ L +L++F+ I ++ + + LA+ H + Sbjct: 63 IVKLLDVIHTENKLYLVFELLHQ-DLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSH 121 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 R+LHRD+KP N+L++ E + L+DF +++ + H V V L Y APE Sbjct: 122 ---RVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPE 172
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 65.5 bits (158), Expect = 1e-10 Identities = 49/169 (28%), Positives = 82/169 (48%), Gaps = 3/169 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK A G +VA+K++ + +G+ E+ L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 + DS ++LI+ FL + + + ID ++ + + + + H V LH Sbjct: 70 LMQDSRLYLIFEFLSMDVKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRGV---LH 126 Query: 459 RDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+KP N+L+DN+ L+DF +++ H V V L Y APE Sbjct: 127 RDLKPQNLLIDNKGVIKLADFGLARAFGIPVRVYTHEV--VTLWYRAPE 173
>M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragment) Length = 862 Score = 65.1 bits (157), Expect = 2e-10 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IGSG +G YKA + G L AIK + + + Q E+ + C+H N+V G +L Sbjct: 11 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHANIVAYFGSYL 70 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++++ F GG+L+ P+ + ++ + + L YLH +HRD Sbjct: 71 RRDKLWICMEFCGGGSLQDIY--HVTGPLSELQIAYVSRETLQGLYYLHSK---GKMHRD 125 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +NILL + L+DF VS Sbjct: 126 IKGANILLTDNGHVKLADFGVS 147
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/158 (29%), Positives = 77/158 (48%), Gaps = 4/158 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPG-ILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRCRHDN 257 F +G G FG Y A + +VA+K L + + G++ Q + E++ +H N Sbjct: 43 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 102 Query: 258 LVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDN 437 ++ L Y ++LI + P G L + +Q+ K +D + I ++A AL Y HD Sbjct: 103 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK--LDEQRTATIIEELADALTYCHDK 160 Query: 438 CVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFR 551 +++HRD+KP N+LL ++DF S T R Sbjct: 161 ---KVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLR 195
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 65.1 bits (157), Expect = 2e-10 Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 1/148 (0%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVT 266 ++ IG G +G YKA +VAIK + + + AE+ L H+N+V Sbjct: 25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVK 84 Query: 267 LIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 G+ E++++ + G+L R I R+ + L YLH Sbjct: 85 YHGFIRKSYELYILLEYCANGSLRRLI-SRSSTGLSENESKTYVTQTLLGLKYLHGE--- 140 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVS 530 ++HRD+K +NILL + T L+DF VS Sbjct: 141 GVIHRDIKAANILLSADNTVKLADFGVS 168
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 65.1 bits (157), Expect = 2e-10 Identities = 44/161 (27%), Positives = 76/161 (47%), Gaps = 3/161 (1%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGI--QQFQAEVK 230 + TV + N +G G FG A + G VA+K++ + ++ E+K Sbjct: 13 FGTVFEITNRYTELNPVGMGAFGLVCSAVDRLTGQNVAVKKVMKPFSTSVLAKRTYRELK 72 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVA 410 L +H+NL+TL +S E N L G +L R + RP++ + + + Sbjct: 73 LLKHLKHENLITLDDIFISPLEDIYFVNELQGTDLHRLL---NSRPLEKQFIQYFTYQIM 129 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R L Y+H ++HRD+KPSNIL++ + DF +++ Sbjct: 130 RGLKYIHS---AGVIHRDLKPSNILINENCDLKICDFGLAR 167
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 65.1 bits (157), Expect = 2e-10 Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 1/167 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FG + G VA+K I Q F AE + + RH NLV L+G + Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVE 257 Query: 288 DSE-MFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + ++++ ++ G+L +++ R + + L K +LDV A+ YL N +HRD Sbjct: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN---NFVHRD 314 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 + N+L+ + A +SDF ++K +++ PV + APE Sbjct: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPE 356
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 65.1 bits (157), Expect = 2e-10 Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 1/167 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FG + G VA+K I Q F AE + + RH NLV L+G + Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVE 257 Query: 288 DSE-MFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + ++++ ++ G+L +++ R + + L K +LDV A+ YL N +HRD Sbjct: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN---NFVHRD 314 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 + N+L+ + A +SDF ++K +++ PV + APE Sbjct: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPE 356
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/170 (28%), Positives = 87/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK + G +VA+K++ + +G+ EV L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQE-RTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + +S ++LI+ FL +L++++ + + +D ++ + + + H R+L Sbjct: 70 LMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+DN+ L+DF +S+ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDNKGVIKLADFGLSRAFGVPVRVYTHEV--VTLWYRAPE 173
>M4K1_HUMAN (Q92918) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) Length = 833 Score = 64.7 bits (156), Expect = 2e-10 Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 1/142 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G +G +KA + G LVA+K + + + Q E+ L CRH N+V G +L Sbjct: 23 LGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYL 82 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 ++++ F G+L+ Q + + + +V + LAYLH + +HRD Sbjct: 83 WLQKLWICMEFCGAGSLQDIYQ--VTGSLSELQISYVCREVLQGLAYLHSQ---KKIHRD 137 Query: 465 VKPSNILLDNEYTAYLSDFWVS 530 +K +NIL+++ L+DF +S Sbjct: 138 IKGANILINDAGEVRLADFGIS 159
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 64.7 bits (156), Expect = 2e-10 Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 1/167 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG G FG + G VA+K I Q F AE + + RH NLV L+G + Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVE 257 Query: 288 DSE-MFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 + ++++ ++ G+L +++ R + + L K +LDV A+ YL N +HRD Sbjct: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVLEAMEYLEGN---NFVHRD 314 Query: 465 VKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 + N+L+ + A +SDF ++K +++ PV + APE Sbjct: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPE 356
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 64.7 bits (156), Expect = 2e-10 Identities = 48/170 (28%), Positives = 86/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK G +VA+K++ + +G+ E+ L RH N+V+L Sbjct: 10 IGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIALDVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ +D ++ + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ T L+DF +++ H V V L Y +PE Sbjct: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV--VTLWYRSPE 173
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 64.7 bits (156), Expect = 2e-10 Identities = 48/170 (28%), Positives = 87/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK G +VA+K++ + +G+ E+ L RH N+V+L Sbjct: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTK-RPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ + +D ++ + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ T L+DF +++ H V V L Y +PE Sbjct: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV--VTLWYRSPE 173
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 64.3 bits (155), Expect = 3e-10 Identities = 51/170 (30%), Positives = 86/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK A G +VA+K++ + +G+ E+ L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGVHKATGQIVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIAL-DVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ ML K L + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPSGQYLEAMLVKSYLYQILQGIIFCHAR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ L+DF +++ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEV--VTLWYRAPE 173
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 64.3 bits (155), Expect = 3e-10 Identities = 54/187 (28%), Positives = 84/187 (44%), Gaps = 9/187 (4%) Frame = +3 Query: 72 VRAAGSFNASNCIGSGGFGAT-YKAEIAPGILVAIKRLA---IGRFQGIQQFQAEVKTLG 239 +R G + IG G F + G VAIK +A I + + + Q + E+ + Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 240 RCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHKIALDVARA 416 RH N+V L S S+++++ F+ GG L +R + + + R + +D Sbjct: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD---- 120 Query: 417 LAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWE----FRNSCNHPVSRVL 584 A H +C + HRD+KP N+LLD +SDF +S E R +C P Sbjct: 121 -AVAHCHC-KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP----- 173 Query: 585 LGYVAPE 605 YVAPE Sbjct: 174 -NYVAPE 179
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 64.3 bits (155), Expect = 3e-10 Identities = 44/179 (24%), Positives = 92/179 (51%), Gaps = 3/179 (1%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRH 251 ++ F +G G + YK G LVA+K + + +G E+ + H Sbjct: 4 SSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIREISLMKELDH 63 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKR-PIDWRMLHKIALDVARALAYL 428 +N+VTL +++++ L++ F+ +L+++++ + +D +++ + + + + Sbjct: 64 ENIVTLYDVIHTENKLTLVFEFMDK-DLKKYMEAHGNQGALDLKIVKSFIFQLLKGIMFC 122 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HDN R+LHRD+KP N+L++N+ L DF +++ N+ ++ V V L Y AP+ Sbjct: 123 HDN---RVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEV--VTLWYRAPD 176
>MP2K1_PANTR (Q9XT09) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 64.3 bits (155), Expect = 3e-10 Identities = 43/143 (30%), Positives = 78/143 (54%), Gaps = 2/143 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G+G G +K P G+++A K + + I+ Q E++ L C +V G Sbjct: 73 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 132 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 SD E+ + + GG+L++ +++ + P ++L K+++ V + L YL + +I+HR Sbjct: 133 YSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSIAVIKGLTYLREK--HKIMHR 188 Query: 462 DVKPSNILLDNEYTAYLSDFWVS 530 DV+PSNIL+++ L DF VS Sbjct: 189 DVQPSNILVNSRGEIKLCDFGVS 211
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 64.3 bits (155), Expect = 3e-10 Identities = 47/142 (33%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A +I +VAIK+++ Q +++Q EVK L + RH N + G Sbjct: 34 IGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPNTIEYKG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + I + LAYLH++ ++ Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEMEIAAITHGALQGLAYLHNH---NMI 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRDVK NILL L DF Sbjct: 149 HRDVKAGNILLTEPGLVKLGDF 170
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 64.3 bits (155), Expect = 3e-10 Identities = 51/183 (27%), Positives = 84/183 (45%), Gaps = 11/183 (6%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPGI-LVAIKRLAIGRFQ-GIQQFQAEVKTLGRCRHDNLV 263 + IGSG A AP VAIKR+ + + Q + + E++ + +C H N+V Sbjct: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQ------ERTKRPIDWRMLHKIALDVARALAY 425 + + E++L+ L GG++ I+ E +D + I +V L Y Sbjct: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136 Query: 426 LHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YV 596 LH N +HRDVK NILL + + ++DF VS + + V + +G ++ Sbjct: 137 LHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 597 APE 605 APE Sbjct: 194 APE 196
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 64.3 bits (155), Expect = 3e-10 Identities = 51/183 (27%), Positives = 84/183 (45%), Gaps = 11/183 (6%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPGI-LVAIKRLAIGRFQ-GIQQFQAEVKTLGRCRHDNLV 263 + IGSG A AP VAIKR+ + + Q + + E++ + +C H N+V Sbjct: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQ------ERTKRPIDWRMLHKIALDVARALAY 425 + + E++L+ L GG++ I+ E +D + I +V L Y Sbjct: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136 Query: 426 LHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YV 596 LH N +HRDVK NILL + + ++DF VS + + V + +G ++ Sbjct: 137 LHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 597 APE 605 APE Sbjct: 194 APE 196
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 64.3 bits (155), Expect = 3e-10 Identities = 48/170 (28%), Positives = 86/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK G +VA+K++ + +G+ E+ L RH N+V+L Sbjct: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIALDVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ +D ++ + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ T L+DF +++ H V V L Y +PE Sbjct: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV--VTLWYRSPE 173
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 63.9 bits (154), Expect = 4e-10 Identities = 48/170 (28%), Positives = 86/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK G +VA+K++ + +G+ E+ L RH N+V+L Sbjct: 10 IGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIALDVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ +D ++ + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ T L+DF +++ H V V L Y +PE Sbjct: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV--VTLWYRSPE 173
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 63.9 bits (154), Expect = 4e-10 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 3/161 (1%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGI--QQFQAEVK 230 + TV + N +G G FG A + G VAIK++ + ++ E+K Sbjct: 13 FGTVFEITNRYTDLNPVGMGAFGLVCSATDTLAGQPVAIKKIMKPFSTAVLAKRTYRELK 72 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVA 410 L RH+NL+ L LS E L G +L R +Q R P++ + + + Sbjct: 73 LLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTR---PLEKQFVQYFLYQIL 129 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R L Y+H ++HRD+KPSNIL++ + DF +++ Sbjct: 130 RGLKYVHS---AGVIHRDLKPSNILINENCDLKICDFGLAR 167
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 63.9 bits (154), Expect = 4e-10 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 3/161 (1%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGI--QQFQAEVK 230 + TV +N N +G G FG A + VAIK++ + ++ E+K Sbjct: 13 FGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELK 72 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVA 410 L RH+NL+ L LS E L G +L R +Q R P++ + + + Sbjct: 73 LLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTR---PLEKQFVQYFLYQIL 129 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R L Y+H ++HRD+KPSNIL++ + DF +++ Sbjct: 130 RGLKYVHS---AGVIHRDLKPSNILINENCDLKICDFGLAR 167
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 G IGSG FG YK + + V + + Q +Q F+ EV L + RH N++ Sbjct: 455 GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL 514 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +GY + ++ ++ + G +L + + + L IA A+ + YLH Sbjct: 515 LFMGYS-TKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQGMDYLH---A 569 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 I+HRD+K +NI L + T + DF ++ K+ W + +L ++APE Sbjct: 570 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL--WMAPE 623
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 63.9 bits (154), Expect = 4e-10 Identities = 33/105 (31%), Positives = 59/105 (56%), Gaps = 1/105 (0%) Frame = +3 Query: 222 EVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRP-IDWRMLHKIA 398 E + L + R ++ ++G + ++ ++P G+L + +T+ P I W + +I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRIL 125 Query: 399 LDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 ++A + YLH N P +LH D+K NILLDNE+ ++DF +SK Sbjct: 126 HEIALGVNYLH-NMNPPLLHHDLKTQNILLDNEFHVKIADFGLSK 169
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 63.9 bits (154), Expect = 4e-10 Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 2/145 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRHDNLVTLIGYH 281 +G G +G K + G +VAIK + + + E+K L + RH+NLV LI Sbjct: 10 VGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVF 69 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ L++ F+ L+ + ++ + L K + RA+ YLH+N I+HR Sbjct: 70 RQKKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRAIEYLHNN---NIIHR 124 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKT 536 D+KP NIL+ L DF ++T Sbjct: 125 DIKPENILVSQSGITKLCDFGFART 149
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 63.9 bits (154), Expect = 4e-10 Identities = 33/108 (30%), Positives = 59/108 (54%) Frame = +3 Query: 207 QQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRML 386 QQF++EV L R H N+V I +I ++ GNL ++ ++ + + Sbjct: 130 QQFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETV 189 Query: 387 HKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVS 530 ++ALD++R + YLH ++HRD+K +N+LL++E ++DF S Sbjct: 190 LRLALDISRGMEYLHSQ---GVIHRDLKSNNLLLNDEMRVKVADFGTS 234
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 G IGSG FG YK + + V + + Q +Q F+ EV L + RH N++ Sbjct: 17 GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL 76 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +GY + ++ ++ + G +L + + + L IA A+ + YLH Sbjct: 77 LFMGYS-TKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQGMDYLH---A 131 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 I+HRD+K +NI L + T + DF ++ K+ W + +L ++APE Sbjct: 132 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL--WMAPE 185
>CDKL3_RAT (Q9JM01) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIATRE) Length = 593 Score = 63.9 bits (154), Expect = 4e-10 Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 2/145 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRHDNLVTLIGYH 281 +G G +G K + G +VAIK + + + E+K L + RH+NLV LI Sbjct: 10 VGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVF 69 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ L++ F+ L+ + ++ + L K + RA+ YLH+N I+HR Sbjct: 70 RQKKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRAIEYLHNN---NIIHR 124 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKT 536 D+KP NIL+ L DF ++T Sbjct: 125 DIKPENILVSQSGITKLCDFGFART 149
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 G IGSG FG YK + + V + + Q +Q F+ EV L + RH N++ Sbjct: 495 GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL 554 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +GY + ++ ++ + G +L + + + L IA A+ + YLH Sbjct: 555 LFMGYS-TKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQGMDYLH---A 609 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 I+HRD+K +NI L + T + DF ++ K+ W + +L ++APE Sbjct: 610 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL--WMAPE 663
>CDC2_CHERU (P93101) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 63.9 bits (154), Expect = 4e-10 Identities = 49/170 (28%), Positives = 87/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRF-QGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YKA + +A+K++ + + +G+ E+ L +H N+V L Sbjct: 10 IGEGTYGVVYKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHGNIVRLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 S+ ++L++ +L +L++ + D RM+ + + R +AY H + R+LH Sbjct: 70 VHSEKRLYLVFEYLDL-DLKKHMDSCPDFAKDPRMIKRFLYQILRGIAYCHSH---RVLH 125 Query: 459 RDVKPSNILLDNEYTAY-LSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+KP N+L+D + A L+DF +++ + H V V L Y APE Sbjct: 126 RDLKPQNLLIDRQTNALKLADFGLARAFGIPVRTFTHEV--VTLWYRAPE 173
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 G IGSG FG YK + + V + + Q +Q F+ EV L + RH N++ Sbjct: 495 GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL 554 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +GY + ++ ++ + G +L + + + L IA A+ + YLH Sbjct: 555 LFMGYS-TKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQGMDYLH---A 609 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 I+HRD+K +NI L + T + DF ++ K+ W + +L ++APE Sbjct: 610 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL--WMAPE 663
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 G IGSG FG YK + + V + + Q +Q F+ EV L + RH N++ Sbjct: 81 GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL 140 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +GY + ++ ++ + G +L + + + L IA A+ + YLH Sbjct: 141 LFMGYS-TKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQGMDYLH---A 195 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 I+HRD+K +NI L + T + DF ++ K+ W + +L ++APE Sbjct: 196 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL--WMAPE 249
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 63.9 bits (154), Expect = 4e-10 Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 13/198 (6%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGR--FQGIQQFQAEV 227 ++ + + F S + SGGFG L+ +K + G + + E Sbjct: 5 MSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEA 64 Query: 228 KTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDV 407 K + R RH +V L+G + + + L+ ++ GNL ++ P+ + +I L++ Sbjct: 65 KMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLS--VKGRIILEI 122 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWV-SKTTWEFRNSCNHPVSRVL 584 + YLH ++H+D+KP NIL+DN++ ++D + S W N+ H R + Sbjct: 123 IEGMCYLHGK---GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREV 179 Query: 585 LG----------YVAPEY 608 G Y+APE+ Sbjct: 180 DGTAKKNGGTLYYMAPEH 197
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 63.9 bits (154), Expect = 4e-10 Identities = 41/142 (28%), Positives = 69/142 (48%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IGSG FG + E I VAIK + G + F E K + + H LV L G + Sbjct: 277 IGSGQFGVVHLGEWRAHIPVAIKAINEGSMSE-EDFIEEAKVMMKLSHSRLVQLYGVCIQ 335 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 ++++ F+ G L +++ER K + +L + D+ +AYL +C +HRD+ Sbjct: 336 QKPLYIVTEFMENGCLLDYLRER-KGQLQKALLLSMCQDICEGMAYLERSC---YIHRDL 391 Query: 468 KPSNILLDNEYTAYLSDFWVSK 533 N L+ + +SDF +++ Sbjct: 392 AARNCLVSSACVVKISDFGMAR 413
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.9 bits (154), Expect = 4e-10 Identities = 51/183 (27%), Positives = 84/183 (45%), Gaps = 11/183 (6%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPGI-LVAIKRLAIGRFQ-GIQQFQAEVKTLGRCRHDNLV 263 + IGSG A AP VAIKR+ + + Q + + E++ + +C H N+V Sbjct: 17 YELQEVIGSGATAVVQAAYCAPKKERVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQ------ERTKRPIDWRMLHKIALDVARALAY 425 + + E++L+ L GG++ I+ E +D + I +V L Y Sbjct: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIATILREVLEGLEY 136 Query: 426 LHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YV 596 LH N +HRDVK NILL + + ++DF VS + + V + +G ++ Sbjct: 137 LHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 597 APE 605 APE Sbjct: 194 APE 196
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 G IGSG FG YK + + V + + Q +Q F+ EV L + RH N++ Sbjct: 65 GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL 124 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +GY + ++ ++ + G +L + + + L IA A+ + YLH Sbjct: 125 LFMGYS-TKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQGMDYLH---A 179 Query: 444 PRILHRDVKPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVLLGYVAPE 605 I+HRD+K +NI L + T + DF ++ K+ W + +L ++APE Sbjct: 180 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL--WMAPE 233
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 63.9 bits (154), Expect = 4e-10 Identities = 43/169 (25%), Positives = 87/169 (51%), Gaps = 3/169 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YKA+ G LVA+K++ + +G+ E+ L +H N+V L+ Sbjct: 10 IGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 ++ +++L++ FL +L++++ + ++ + + +++ H + R++H Sbjct: 70 VHNERKLYLVFEFL-SQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSH---RVIH 125 Query: 459 RDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+KP N+L++ L+DF +++ + H V V L Y APE Sbjct: 126 RDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEV--VTLWYRAPE 172
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 63.9 bits (154), Expect = 4e-10 Identities = 45/175 (25%), Positives = 90/175 (51%), Gaps = 6/175 (3%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRHDNLVTLIGYH 281 +G+G + YK G+ VA+K + + +G E+ + +H+N+V L Sbjct: 15 LGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 74 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRP----IDWRMLHKIALDVARALAYLHDNCVPR 449 +++++ L++ F+ +L++F+ R R ++ ++ + + +A+ H+N R Sbjct: 75 HTENKLTLVFEFMDN-DLKKFMDSRLDREMPRGLELSLVKYFQWQLLQGVAFCHEN---R 130 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPEYAM 614 ILHRD+KP N+L++N+ L DF +++ N+ + V V L Y AP+ M Sbjct: 131 ILHRDLKPQNLLINNKGQLKLGDFGLARAFGIPVNTFSSEV--VTLWYRAPDVLM 183
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 63.9 bits (154), Expect = 4e-10 Identities = 48/170 (28%), Positives = 87/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK + G +VA+K++ + +G+ EV L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQE-RTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + +S ++LI+ FL +L++++ + + +D ++ + + + H R+L Sbjct: 70 LMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+DN+ L+DF +++ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV--VTLWYRAPE 173
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 63.9 bits (154), Expect = 4e-10 Identities = 48/170 (28%), Positives = 87/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK + G +VA+K++ + +G+ EV L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQE-RTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + +S ++LI+ FL +L++++ + + +D ++ + + + H R+L Sbjct: 70 LMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+DN+ L+DF +++ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV--VTLWYRAPE 173
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 63.9 bits (154), Expect = 4e-10 Identities = 48/170 (28%), Positives = 87/170 (51%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK + G +VA+K++ + +G+ EV L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQE-RTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + +S ++LI+ FL +L++++ + + +D ++ + + + H R+L Sbjct: 70 LMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+DN+ L+DF +++ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV--VTLWYRAPE 173
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 63.5 bits (153), Expect = 5e-10 Identities = 45/185 (24%), Positives = 91/185 (49%), Gaps = 6/185 (3%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRH 251 ++ F +G+G + YK + G+ VA+K + + +G E+ + +H Sbjct: 2 SSSQFKQLEKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 61 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT----KRPIDWRMLHKIALDVARAL 419 DN+V L +++++ L++ ++ +L++++ RT R ++ ++ + L Sbjct: 62 DNIVRLYDVIHTENKLTLVFEYMDN-DLKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGL 120 Query: 420 AYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVA 599 A+ H+N +ILHRD+KP N+L+ L DF +++ N+ + V V L Y A Sbjct: 121 AFCHEN---KILHRDLKPQNLLITKRGQLKLGDFGLARAFGIPVNTFSSEV--VTLWYRA 175 Query: 600 PEYAM 614 P+ M Sbjct: 176 PDVLM 180
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 63.5 bits (153), Expect = 5e-10 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G + A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 255 IGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL 314 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E+F++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 315 VGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHAN---QVIHRD 368 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K N+LL E + L+DF Sbjct: 369 IKSDNVLLGMEGSVKLTDF 387
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 63.5 bits (153), Expect = 5e-10 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G + A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 255 IGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL 314 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E+F++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 315 VGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHAN---QVIHRD 368 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K N+LL E + L+DF Sbjct: 369 IKSDNVLLGMEGSVKLTDF 387
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 63.5 bits (153), Expect = 5e-10 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G + A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 255 IGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL 314 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E+F++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 315 VGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHAN---QVIHRD 368 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K N+LL E + L+DF Sbjct: 369 IKSDNVLLGMEGSVKLTDF 387
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 63.5 bits (153), Expect = 5e-10 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G + A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 255 IGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL 314 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E+F++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 315 VGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHAN---QVIHRD 368 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K N+LL E + L+DF Sbjct: 369 IKSDNVLLGMEGSVKLTDF 387
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 63.5 bits (153), Expect = 5e-10 Identities = 44/144 (30%), Positives = 69/144 (47%), Gaps = 2/144 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYHL 284 +G G FG YK + VA+K Q ++ +F E K L + H N+V LIG Sbjct: 569 LGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 628 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHD-NCVPRILHR 461 +++I + GG+ F++ R K + + L K +LD A + YL NC+ HR Sbjct: 629 QRQPVYIIMELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCI----HR 683 Query: 462 DVKPSNILLDNEYTAYLSDFWVSK 533 D+ N L+ +SDF +S+ Sbjct: 684 DLAARNCLVGENNVLKISDFGMSR 707
>MP2K5_RAT (Q62862) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 448 Score = 63.5 bits (153), Expect = 5e-10 Identities = 52/171 (30%), Positives = 87/171 (50%), Gaps = 5/171 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G G G YKA P G ++A+K + + +Q Q +E++ L +C ++ G Sbjct: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ + + F+ GG+L+ + R I +L +IA+ V + L YL +ILHR Sbjct: 232 FVENRISICTEFMDGGSLDVY------RKIPEHVLGRIAVAVVKGLTYLWSL---KILHR 282 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YVAPE 605 DVKPSN+L++ L DF VS + NS +++ +G Y+APE Sbjct: 283 DVKPSNMLVNTSGQVKLCDFGVST---QLVNS----IAKTYVGTNAYMAPE 326
>MP2K5_MOUSE (Q9WVS7) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 448 Score = 63.5 bits (153), Expect = 5e-10 Identities = 52/171 (30%), Positives = 87/171 (50%), Gaps = 5/171 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G G G YKA P G ++A+K + + +Q Q +E++ L +C ++ G Sbjct: 172 LGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ + + F+ GG+L+ + R I +L +IA+ V + L YL +ILHR Sbjct: 232 FVENRISICTEFMDGGSLDVY------RKIPEHVLGRIAVAVVKGLTYLWSL---KILHR 282 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YVAPE 605 DVKPSN+L++ L DF VS + NS +++ +G Y+APE Sbjct: 283 DVKPSNMLVNTGGQVKLCDFGVST---QLVNS----IAKTYVGTNAYMAPE 326
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 63.5 bits (153), Expect = 5e-10 Identities = 45/185 (24%), Positives = 92/185 (49%), Gaps = 6/185 (3%) Frame = +3 Query: 78 AAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQA-EVKTLGRCRH 251 ++ F +G+G + YK G+ VA+K + + +G E+ + +H Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 Query: 252 DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT----KRPIDWRMLHKIALDVARAL 419 +N+V L +++++ L++ F+ +L++++ RT R ++ ++ + + L Sbjct: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Query: 420 AYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVA 599 A+ H+N +ILHRD+KP N+L++ L DF +++ N+ + V V L Y A Sbjct: 122 AFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV--VTLWYRA 176 Query: 600 PEYAM 614 P+ M Sbjct: 177 PDVLM 181
>TGFR2_RAT (P38438) TGF-beta receptor type-2 precursor (EC 2.7.11.30)| (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) Length = 567 Score = 63.5 bits (153), Expect = 5e-10 Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 14/155 (9%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRF--QGIQQFQAEVKTLG--RCRHDNLVTLIG 275 +G G F YKA++ + +A+ F + ++ E +H+N++ + Sbjct: 250 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLT 309 Query: 276 YHLSDSEM----FLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +EM +LI F GNL+ ++ T+ I W L K+ +AR +A+LH + Sbjct: 310 AEERKTEMGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGIAHLHSDHT 366 Query: 444 P------RILHRDVKPSNILLDNEYTAYLSDFWVS 530 P I+HRD+K SNIL+ N+ T L DF +S Sbjct: 367 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLS 401
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 63.2 bits (152), Expect = 6e-10 Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G A E G VA+K++ + + Q + EV + HDN+V + +L Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 514 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ FL GG L + T ++ + + L V RAL+YLH+ ++HRD Sbjct: 515 VGDELWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLRALSYLHNQ---GVIHRD 568 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K +ILL ++ LSDF Sbjct: 569 IKSDSILLTSDGRIKLSDF 587
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 63.2 bits (152), Expect = 6e-10 Identities = 57/199 (28%), Positives = 95/199 (47%), Gaps = 21/199 (10%) Frame = +3 Query: 6 SNRRREVTVFVDIGAPLTYETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRL 182 S+R +E + PLT ++ +F +G+G +G A ++ G LVAIK L Sbjct: 25 SSRIKETRKVKLLYNPLTKRQILN---NFEILATLGNGQYGKVKLARDLGTGALVAIKIL 81 Query: 183 AIGRFQGIQQFQA-----------EVKTLGRCRHDNLVTLIGYHLSDSE---MFLIYNFL 320 RF+ + E++ + RC H+N+V L L+D E ++L+ + Sbjct: 82 --NRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEI-LNDPESTKVYLVLEYC 138 Query: 321 PGGNL----ERFIQERTKRP--IDWRMLHKIALDVARALAYLHDNCVPRILHRDVKPSNI 482 G + E ++ + P + ++ K+ LDV L YLH I HRD+KPSN+ Sbjct: 139 SRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQ---GITHRDIKPSNL 195 Query: 483 LLDNEYTAYLSDFWVSKTT 539 L+ + T +SDF V+ +T Sbjct: 196 LISSNGTVKISDFGVAMST 214
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 63.2 bits (152), Expect = 6e-10 Identities = 45/142 (31%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A ++ +VAIK+++ Q +++Q EVK L R +H N + G Sbjct: 34 IGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + I + LAYLH + + + Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEVEIAAITHGALQGLAYLHSHTM---I 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRD+K NILL L+DF Sbjct: 149 HRDIKAGNILLTEPGQVKLADF 170
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 63.2 bits (152), Expect = 6e-10 Identities = 45/142 (31%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A ++ +VAIK+++ Q +++Q EVK L R +H N + G Sbjct: 34 IGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + I + LAYLH + + + Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEVEIAAITHGALQGLAYLHSHTM---I 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRD+K NILL L+DF Sbjct: 149 HRDIKAGNILLTEPGQVKLADF 170
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 63.2 bits (152), Expect = 6e-10 Identities = 45/142 (31%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A ++ +VAIK+++ Q +++Q EVK L R +H N + G Sbjct: 34 IGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + I + LAYLH + + + Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEVEIAAITHGALQGLAYLHSHTM---I 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRD+K NILL L+DF Sbjct: 149 HRDIKAGNILLTEPGQVKLADF 170
>CDC22_MEDSA (Q05006) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 294 Score = 63.2 bits (152), Expect = 6e-10 Identities = 49/170 (28%), Positives = 86/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRF-QGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YKA + A +A+K++ + + +G+ E+ L +H N+V L Sbjct: 10 IGEGTYGVVYKARDRATNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHRNIVRLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 S+ ++L++ +L +L++F+ + D R + + +AY H + R+LH Sbjct: 70 VHSEKRLYLVFEYLDL-DLKKFMDSSPEFAKDQRQIKMFLYQILCGIAYCHSH---RVLH 125 Query: 459 RDVKPSNILLDNEYTAY-LSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+KP N+L+D A L+DF +++ + H V V L Y APE Sbjct: 126 RDLKPQNLLIDRSSNAVKLADFGLARAFGIPVRTFTHEV--VTLWYRAPE 173
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 63.2 bits (152), Expect = 6e-10 Identities = 47/170 (27%), Positives = 86/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK G +V +K++ + +G+ E+ L RH N+V+L Sbjct: 10 IGEGTYGVVYKGRHKTTGQVVTMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTK-RPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 + DS ++LI+ FL +L++++ + +D ++ + + + + H R+L Sbjct: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+D++ T L+DF +++ H V V L Y +PE Sbjct: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV--VTLWYRSPE 173
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 63.2 bits (152), Expect = 6e-10 Identities = 42/149 (28%), Positives = 74/149 (49%), Gaps = 4/149 (2%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQ--GIQ-QFQAEVKTLGRCRHD 254 +F +G G FG Y A E +VA+K L + + G++ Q + E++ +H Sbjct: 81 NFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHP 140 Query: 255 NLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHD 434 N++ L Y ++LI + P G L + +Q+ R D + I +++ AL Y H Sbjct: 141 NILQLYNYFYDQQRIYLILEYAPRGELYKELQK--SRTFDEQRTATIMEELSDALTYCHK 198 Query: 435 NCVPRILHRDVKPSNILLDNEYTAYLSDF 521 +++HRD+KP N+LL + ++DF Sbjct: 199 K---KVIHRDIKPENLLLGLQGELKIADF 224
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 63.2 bits (152), Expect = 6e-10 Identities = 55/181 (30%), Positives = 86/181 (47%), Gaps = 9/181 (4%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEI-APGILVAIKRLAIGRFQGIQQ-FQAEVKTLGRCRHDNLV 263 F +G+G F AE A G L A+K + +G + + E+ L + +H+N+V Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 L + S + ++L+ + GG L +R +++ D L + LD A+ YLH Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLD---AVYYLHR-- 137 Query: 441 VPRILHRDVKPSNILL---DNEYTAYLSDFWVSKTTWE---FRNSCNHPVSRVLLGYVAP 602 I+HRD+KP N+L D E +SDF +SK + +C P GYVAP Sbjct: 138 -MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP------GYVAP 190 Query: 603 E 605 E Sbjct: 191 E 191
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 63.2 bits (152), Expect = 6e-10 Identities = 55/181 (30%), Positives = 86/181 (47%), Gaps = 9/181 (4%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEI-APGILVAIKRLAIGRFQGIQQ-FQAEVKTLGRCRHDNLV 263 F +G+G F AE A G L A+K + +G + + E+ L + +H+N+V Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 L + S + ++L+ + GG L +R +++ D L + LD A+ YLH Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLD---AVYYLHR-- 137 Query: 441 VPRILHRDVKPSNILL---DNEYTAYLSDFWVSKTTWE---FRNSCNHPVSRVLLGYVAP 602 I+HRD+KP N+L D E +SDF +SK + +C P GYVAP Sbjct: 138 -MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP------GYVAP 190 Query: 603 E 605 E Sbjct: 191 E 191
>CDKL3_MACFA (Q4R8T9) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 590 Score = 62.8 bits (151), Expect = 8e-10 Identities = 43/145 (29%), Positives = 69/145 (47%), Gaps = 2/145 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIA-PGILVAIKRLAIGRFQGIQQF-QAEVKTLGRCRHDNLVTLIGYH 281 +G G +G K + G +VAIK Q + + E+K L + H+NLV LI Sbjct: 10 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVF 69 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ L++ F+ L+ + ++ + L K + RA+ YLH N I+HR Sbjct: 70 RQKKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRAIDYLHSN---NIIHR 124 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKT 536 D+KP NIL+ L DF ++T Sbjct: 125 DIKPENILVSQSGITKLCDFGFART 149
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 62.8 bits (151), Expect = 8e-10 Identities = 47/143 (32%), Positives = 64/143 (44%), Gaps = 16/143 (11%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQ----GIQQFQAEVKTLGRCRHDNLVTLIG 275 IG+GGFG Y+A G VA+K Q + + E + RH N++ L G Sbjct: 130 IGAGGFGQVYRATWQ-GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRG 188 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQE------------RTKRPIDWRMLHKIALDVARAL 419 L + L+ F GG L R + R R I +L A+ +AR + Sbjct: 189 VCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGM 248 Query: 420 AYLHDNCVPRILHRDVKPSNILL 488 YLH+ ILHRD+K SNILL Sbjct: 249 LYLHEEAFVPILHRDLKSSNILL 271
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 62.8 bits (151), Expect = 8e-10 Identities = 44/169 (26%), Positives = 76/169 (44%), Gaps = 1/169 (0%) Frame = +3 Query: 102 NCIGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 NC G G FG+ Y+A+ I+ VA+K+L + + E + L H N++ G Sbjct: 21 NC-GGGSFGSVYRAKWISQDKEVAVKKLL--------KIEKEAEILSVLSHRNIIQFYGV 71 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 L ++ + G+L +I +D + A DVA+ + YLH +++H Sbjct: 72 ILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIH 131 Query: 459 RDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+K N+++ + + DF S+ F N H ++APE Sbjct: 132 RDLKSRNVVIAADGVLKICDFGASR----FHNHTTHMSLVGTFPWMAPE 176
>CDKL3_HUMAN (Q8IVW4) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIAMRE) Length = 592 Score = 62.8 bits (151), Expect = 8e-10 Identities = 43/145 (29%), Positives = 69/145 (47%), Gaps = 2/145 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIA-PGILVAIKRLAIGRFQGIQQF-QAEVKTLGRCRHDNLVTLIGYH 281 +G G +G K + G +VAIK Q + + E+K L + H+NLV LI Sbjct: 10 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVF 69 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ L++ F+ L+ + ++ + L K + RA+ YLH N I+HR Sbjct: 70 RQKKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRAIDYLHSN---NIIHR 124 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKT 536 D+KP NIL+ L DF ++T Sbjct: 125 DIKPENILVSQSGITKLCDFGFART 149
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 62.8 bits (151), Expect = 8e-10 Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 3/147 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPGI-LVAIKRLA-IGRFQG-IQQFQAEVKTLGRCRHDNL 260 ++ IG G FG YK +VA+K + +GR + ++ Q E++ + RH N+ Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNI 63 Query: 261 VTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 V ++ +D E+ ++ ++ G L + +++ K P D + IA + AL YLH + Sbjct: 64 VHMLDSFETDKEVVVVTDYAEG-ELLQILEDDGKLPED--QVQAIAAQLVSALYYLHSH- 119 Query: 441 VPRILHRDVKPSNILLDNEYTAYLSDF 521 RILHRD+KP NILL L DF Sbjct: 120 --RILHRDMKPQNILLAKGGGIKLCDF 144
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 62.8 bits (151), Expect = 8e-10 Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 3/147 (2%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPGI-LVAIKRLA-IGRFQG-IQQFQAEVKTLGRCRHDNL 260 ++ IG G FG YK +VA+K + +GR + ++ Q E++ + RH N+ Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNI 63 Query: 261 VTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 V ++ +D E+ ++ ++ G L + +++ K P D + IA + AL YLH + Sbjct: 64 VHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPED--QVQAIAAQLVSALYYLHSH- 119 Query: 441 VPRILHRDVKPSNILLDNEYTAYLSDF 521 RILHRD+KP NILL L DF Sbjct: 120 --RILHRDMKPQNILLAKGGGIKLCDF 144
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 62.8 bits (151), Expect = 8e-10 Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 5/149 (3%) Frame = +3 Query: 102 NCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQF----QAEVKTLGRCRHDNLVT 266 N IG G FG Y A ++ G ++A+K + I + +Q+ + E+ L H N+V+ Sbjct: 1270 NFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVS 1329 Query: 267 LIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 G + ++ + + GG+L ++ R D + L + LAYLH++ Sbjct: 1330 YYGVEVHRDKVNIFMEYCEGGSLAALLEHG--RIEDEMVTQVYTLQLLEGLAYLHES--- 1384 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVSK 533 I+HRDVKP NILLD DF +K Sbjct: 1385 GIVHRDVKPENILLDFNGVIKYVDFGAAK 1413
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 62.8 bits (151), Expect = 8e-10 Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 4/127 (3%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRF---QGIQQFQAEVKTLGRCRHDNLVTLIGY 278 IGSG FG YK I VAIKR + + F EV L + H ++ +G Sbjct: 468 IGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 526 Query: 279 HLSDSEMF-LIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 L+D F ++ ++ GG+L + E+ KR +D + IA+DVAR + YLH N I+ Sbjct: 527 CLNDPSQFAIVTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVARGMEYLH-NLTQPII 584 Query: 456 HRDVKPS 476 HRD+ S Sbjct: 585 HRDLNRS 591
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 62.8 bits (151), Expect = 8e-10 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 8/176 (4%) Frame = +3 Query: 18 REVTVFVDIGAPLTYETVVR--AAGSFNASNCIGSGGFGATYKA-EIAPGILVAIK---- 176 R + D +PLT T R + F +G G FG Y + G + A+K Sbjct: 73 RRSSYTTDPPSPLTGITGFRNYSLDDFEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEK 132 Query: 177 -RLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQE 353 L G + +QF+ EV+ RH N++ L G+ ++LI ++ G L + + Sbjct: 133 KELVEGNVE--KQFRREVEIQSNLRHTNVLRLFGHFHDKDRVYLILEYVVHGELYKLL-- 188 Query: 354 RTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDF 521 R ++ ++ AL YLH I+HRD+KP NILL T +SDF Sbjct: 189 RNQKRFTESTASSYIYQMSEALLYLHGK---NIIHRDIKPENILLHFNDTIKISDF 241
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 62.8 bits (151), Expect = 8e-10 Identities = 50/183 (27%), Positives = 83/183 (45%), Gaps = 11/183 (6%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAPGI-LVAIKRLAIGRFQ-GIQQFQAEVKTLGRCRHDNLV 263 + IGSG A P VAIKR+ + + Q + + E++ + +C H N+V Sbjct: 17 YELQEVIGSGATAVVQAAYCTPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNLERFIQ------ERTKRPIDWRMLHKIALDVARALAY 425 + + E++L+ L GG++ I+ E +D + I +V L Y Sbjct: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEATIATILREVLEGLEY 136 Query: 426 LHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YV 596 LH N +HRDVK NILL + + ++DF VS + + V + +G ++ Sbjct: 137 LHKNGQ---IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 597 APE 605 APE Sbjct: 194 APE 196
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 62.8 bits (151), Expect = 8e-10 Identities = 42/149 (28%), Positives = 74/149 (49%), Gaps = 5/149 (3%) Frame = +3 Query: 105 CIGSGGFGATYKAEIAP-GILVAIKRLAIGRFQG----IQQFQAEVKTLGRCRHDNLVTL 269 C+G GG YKA VA+K L F+ +++F+ E + + N+V + Sbjct: 15 CVGEGGMSFVYKARCRKLNRFVAVKILK-DEFKNNEEIVRRFKKEATAIANLSNPNVVNV 73 Query: 270 IGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPR 449 + D +++ ++ G L+ I+E+ P + + I + VA+AL H + Sbjct: 74 LDVGTQDDINYIVMEYVEGKTLKDIIKEKGALP--YEVAISIGIKVAKALECAHKS---G 128 Query: 450 ILHRDVKPSNILLDNEYTAYLSDFWVSKT 536 I+HRDVKP NIL+ E ++DF ++K+ Sbjct: 129 IIHRDVKPQNILVTEEGVVKVTDFGIAKS 157
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 62.4 bits (150), Expect = 1e-09 Identities = 41/122 (33%), Positives = 64/122 (52%), Gaps = 3/122 (2%) Frame = +3 Query: 249 HDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYL 428 H +++TLI + S S MFL+++ + G L ++ E+ + + I + A+++L Sbjct: 87 HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA--LSEKETRSIMRSLLEAVSFL 144 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVS---KTTWEFRNSCNHPVSRVLLGYVA 599 H N I+HRD+KP NILLD+ LSDF S + + R C P GY+A Sbjct: 145 HAN---NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTP------GYLA 195 Query: 600 PE 605 PE Sbjct: 196 PE 197
>MP2K5_HUMAN (Q13163) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 438 Score = 62.4 bits (150), Expect = 1e-09 Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 5/171 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLVTLIGYH 281 +G G G YKA P G ++A+K + + +Q Q +E++ L +C ++ G Sbjct: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231 Query: 282 LSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHR 461 ++ + + F+ GG+L+ + R + +L +IA+ V + L YL +ILHR Sbjct: 232 FVENRISICTEFMDGGSLDVY------RKMPEHVLGRIAVAVVKGLTYLWSL---KILHR 282 Query: 462 DVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLG---YVAPE 605 DVKPSN+L++ L DF VS + NS +++ +G Y+APE Sbjct: 283 DVKPSNMLVNTRGQVKLCDFGVST---QLVNS----IAKTYVGTNAYMAPE 326
>TGFR2_MOUSE (Q62312) TGF-beta receptor type-2 precursor (EC 2.7.11.30)| (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) Length = 592 Score = 62.4 bits (150), Expect = 1e-09 Identities = 44/155 (28%), Positives = 75/155 (48%), Gaps = 14/155 (9%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRF--QGIQQFQAEVKTLG--RCRHDNLVTLIG 275 +G G F YKA++ + +A+ F + ++ E +H+N++ + Sbjct: 275 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLT 334 Query: 276 YHLSDSEM----FLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +E+ +LI F GNL+ ++ T+ I W L K+ +AR +A+LH + Sbjct: 335 AEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGIAHLHSDHT 391 Query: 444 P------RILHRDVKPSNILLDNEYTAYLSDFWVS 530 P I+HRD+K SNIL+ N+ T L DF +S Sbjct: 392 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLS 426
>PAK4_MOUSE (Q8BTW9) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 593 Score = 62.4 bits (150), Expect = 1e-09 Identities = 43/139 (30%), Positives = 72/139 (51%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G A + + G LVA+K++ + + Q + EV + RH+N+V + +L Sbjct: 329 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYL 388 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ FL GG L + T ++ + + L V +ALA LH ++HRD Sbjct: 389 VGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALAVLH---AQGVIHRD 442 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K +ILL ++ LSDF Sbjct: 443 IKSDSILLTHDGRVKLSDF 461
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 62.4 bits (150), Expect = 1e-09 Identities = 43/131 (32%), Positives = 66/131 (50%), Gaps = 4/131 (3%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQG----IQQFQAEVKTLGRCRHDNLVTLIG 275 IG GGFG Y+A + G VA+K + + +Q E + G +H N++ L G Sbjct: 104 IGVGGFGKVYRA-LWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRG 162 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 L+ + L+ + GG L R + R P +L A+ VAR + YLH++ I+ Sbjct: 163 ACLNPPHLCLVMEYARGGALSRVLAGRRVPP---HVLVNWAVQVARGMNYLHNDAPVPII 219 Query: 456 HRDVKPSNILL 488 HRD+K NIL+ Sbjct: 220 HRDLKSINILI 230
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 62.4 bits (150), Expect = 1e-09 Identities = 49/170 (28%), Positives = 85/170 (50%), Gaps = 4/170 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAI-GRFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YK G +VA+K++ + +G+ E+ L +H N+V L+ Sbjct: 10 IGEGTYGVVYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIAL-DVARALAYLHDNCVPRIL 455 + +S+++L++ FL +L++++ ML K L + + + H R+L Sbjct: 70 LMQESKLYLVFEFL-SMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCHCR---RVL 125 Query: 456 HRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 HRD+KP N+L+DN+ L+DF +++ H V V L Y APE Sbjct: 126 HRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV--VTLWYRAPE 173
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 62.0 bits (149), Expect = 1e-09 Identities = 56/181 (30%), Positives = 86/181 (47%), Gaps = 9/181 (4%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLV 263 ++ + +G+G F AE LVAIK +A +G + + E+ L + +H N+V Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 L + S ++LI + GG L +R ++ K R ++ V A+ YLHD Sbjct: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVE---KGFYTERDASRLIFQVLDAVKYLHD-- 134 Query: 441 VPRILHRDVKPSNIL---LDNEYTAYLSDFWVSKTT---WEFRNSCNHPVSRVLLGYVAP 602 I+HRD+KP N+L LD + +SDF +SK +C P GYVAP Sbjct: 135 -LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTP------GYVAP 187 Query: 603 E 605 E Sbjct: 188 E 188
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 62.0 bits (149), Expect = 1e-09 Identities = 56/181 (30%), Positives = 86/181 (47%), Gaps = 9/181 (4%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLV 263 ++ + +G+G F AE LVAIK +A +G + + E+ L + +H N+V Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 L + S ++LI + GG L +R ++ K R ++ V A+ YLHD Sbjct: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVE---KGFYTERDASRLIFQVLDAVKYLHD-- 134 Query: 441 VPRILHRDVKPSNIL---LDNEYTAYLSDFWVSKTT---WEFRNSCNHPVSRVLLGYVAP 602 I+HRD+KP N+L LD + +SDF +SK +C P GYVAP Sbjct: 135 -LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTP------GYVAP 187 Query: 603 E 605 E Sbjct: 188 E 188
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/161 (26%), Positives = 74/161 (45%), Gaps = 2/161 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG+G FG ++ + V + ++A + Q F+ E++ L + RH N++ +G+ ++ Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGF-MT 374 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 +I + G +L + R D L +A A+ + YLH I+HRD+ Sbjct: 375 RPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDL 430 Query: 468 KPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVL 584 K +NI L T + DF ++ KT W P VL Sbjct: 431 KSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 471
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/162 (27%), Positives = 77/162 (47%), Gaps = 11/162 (6%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHD 254 +F IG G F Y+A + G+ VA+K++ I + E+ L + H Sbjct: 33 NFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 255 NLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQ--ERTKRPIDWRMLHKIALDVARALAYL 428 N++ + D+E+ ++ G+L R I+ ++ KR I R + K + + AL ++ Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHM 152 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSD-----FWVSKTT 539 H R++HRD+KP+N+ + L D F+ SKTT Sbjct: 153 HSR---RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTT 191
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/162 (27%), Positives = 77/162 (47%), Gaps = 11/162 (6%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHD 254 +F IG G F Y+A + G+ VA+K++ I + E+ L + H Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 255 NLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQ--ERTKRPIDWRMLHKIALDVARALAYL 428 N++ + D+E+ ++ G+L R I+ ++ KR I R + K + + AL ++ Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSD-----FWVSKTT 539 H R++HRD+KP+N+ + L D F+ SKTT Sbjct: 153 HSR---RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTT 191
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A +IA G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 349 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSN---QVIHRD 402 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 403 IKSDNILLGMDGSVKLTDF 421
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A +IA G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 349 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSN---QVIHRD 402 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 403 IKSDNILLGMDGSVKLTDF 421
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A +IA G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 349 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSN---QVIHRD 402 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 403 IKSDNILLGMDGSVKLTDF 421
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A +IA G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 349 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSN---QVIHRD 402 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 403 IKSDNILLGMDGSVKLTDF 421
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/148 (27%), Positives = 76/148 (51%), Gaps = 1/148 (0%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVT 266 F+ +G G +G+ YKA G +VAIK++ + +Q+ E+ + +C ++V Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIMQQCDSPHVVK 87 Query: 267 LIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVP 446 G + +++++++ + G++ I+ R K + + I + L YLH Sbjct: 88 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA-TILQSTLKGLEYLH---FM 143 Query: 447 RILHRDVKPSNILLDNEYTAYLSDFWVS 530 R +HRD+K NILL+ E A L+DF V+ Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVA 171
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 335 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 336 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSN---QVIHRD 389 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 390 IKSDNILLGMDGSVKLTDF 408
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 335 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 336 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSN---QVIHRD 389 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 390 IKSDNILLGMDGSVKLTDF 408
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/161 (26%), Positives = 74/161 (45%), Gaps = 2/161 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG+G FG ++ + V + ++A + Q F+ E++ L + RH N++ +G+ ++ Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGF-MT 372 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 +I + G +L + R D L +A A+ + YLH I+HRD+ Sbjct: 373 RPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDL 428 Query: 468 KPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVL 584 K +NI L T + DF ++ KT W P VL Sbjct: 429 KSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 469
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/161 (26%), Positives = 74/161 (45%), Gaps = 2/161 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHLS 287 IG+G FG ++ + V + ++A + Q F+ E++ L + RH N++ +G+ ++ Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGF-MT 372 Query: 288 DSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRDV 467 +I + G +L + R D L +A A+ + YLH I+HRD+ Sbjct: 373 RPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDL 428 Query: 468 KPSNILLDNEYTAYLSDFWVS--KTTWEFRNSCNHPVSRVL 584 K +NI L T + DF ++ KT W P VL Sbjct: 429 KSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 469
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A +IA G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 334 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSN---QVIHRD 387 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 388 IKSDNILLGMDGSVKLTDF 406
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G Y A ++A G VAIK++ + + + E+ + ++ N+V + +L Sbjct: 275 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 334 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ +L GG+L + T+ +D + + + +AL +LH N +++HRD Sbjct: 335 VGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSN---QVIHRD 388 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K NILL + + L+DF Sbjct: 389 IKSDNILLGMDGSVKLTDF 407
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/139 (30%), Positives = 71/139 (51%), Gaps = 1/139 (0%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGYHL 284 IG G G A E G VA+K++ + + Q + EV + HDN+V + +L Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYL 514 Query: 285 SDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILHRD 464 E++++ FL GG L + T ++ + + L V +AL+YLH+ ++HRD Sbjct: 515 VGDELWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLKALSYLHNQ---GVIHRD 568 Query: 465 VKPSNILLDNEYTAYLSDF 521 +K +ILL ++ LSDF Sbjct: 569 IKSDSILLTSDGRIKLSDF 587
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 62.0 bits (149), Expect = 1e-09 Identities = 52/183 (28%), Positives = 83/183 (45%), Gaps = 9/183 (4%) Frame = +3 Query: 84 GSFNASNCIGSGGFGATYKAE-IAPGILVAIK-----RLAIGRFQGIQQFQAEVKTLGRC 245 G + +G G FG A+ + G VA+K LA QG + + E+ L Sbjct: 50 GRYQIIKTLGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQG--RVEREISYLRLL 107 Query: 246 RHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAY 425 RH +++ L S E+ ++ F G L +I +R K P D + + A+ Y Sbjct: 108 RHPHIIKLYDVIKSKDEIIMVIEFA-GKELFDYIVQRGKMPED--EARRFFQQIIAAVEY 164 Query: 426 LHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWE---FRNSCNHPVSRVLLGYV 596 H + +I+HRD+KP N+LLD++ ++DF +S + + SC P Y Sbjct: 165 CHRH---KIVHRDLKPENLLLDDQLNVKIADFGLSNIMTDGNFLKTSCGSP------NYA 215 Query: 597 APE 605 APE Sbjct: 216 APE 218
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/169 (26%), Positives = 76/169 (44%), Gaps = 1/169 (0%) Frame = +3 Query: 102 NCIGSGGFGATYKAE-IAPGILVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLVTLIGY 278 NC G G FG+ Y+A+ I+ VA+K+L + + E + L H N++ G Sbjct: 21 NC-GGGSFGSVYRAKWISQDKEVAVKKLL--------KIEKEAEILSVLSHRNIIQFYGV 71 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 L ++ + G+L +I +D + A DVA+ + YLH +++H Sbjct: 72 ILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIH 131 Query: 459 RDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+K N+++ + + DF S+ F N H ++APE Sbjct: 132 RDLKSRNVVIAADGVLKICDFGASR----FHNHTTHMSLVGTFPWMAPE 176
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 62.0 bits (149), Expect = 1e-09 Identities = 52/184 (28%), Positives = 89/184 (48%), Gaps = 5/184 (2%) Frame = +3 Query: 69 VVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQA--EVKTLG 239 V R A + +G G +G +KA + G VAIK++ +G+++ F A E+K L Sbjct: 12 VKRVADRYLKREVLGEGTYGVVFKAVDTKTGNTVAIKKIRLGKYKEGVNFTALREIKLLK 71 Query: 240 RCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT--KRPIDWRMLHKIALDVAR 413 + N++ LI + L++ F+ +LE I++R P D + ++ L + Sbjct: 72 ELKDSNIIELIDAFPYKGNLHLVFEFMET-DLEAVIRDRNIVLSPADTKSYIQMML---K 127 Query: 414 ALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGY 593 LA+ H V LHRD+KP+N+L+ + L+DF +++ + H V Y Sbjct: 128 GLAFCHKKWV---LHRDMKPNNLLIGADGQLKLADFGLARIFGSPERNFTHQV--FARWY 182 Query: 594 VAPE 605 APE Sbjct: 183 RAPE 186
>SWE1_YEAST (P32944) Mitosis inhibitor protein kinase SWE1 (EC 2.7.11.1)| Length = 819 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/158 (26%), Positives = 76/158 (48%), Gaps = 14/158 (8%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIAP-GILVAIKRLAIGRFQGIQQFQAEVKTLGRCRH----- 251 F + IG G F Y+ A AIK + ++ +++ E+K L + Sbjct: 444 FTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKPNKYNSLKRILLEIKILNEVTNQITMD 503 Query: 252 ----DNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERT----KRPIDWRMLHKIALDV 407 + ++ I + +++ GNL+ F+QE+ KR DWR + KI +++ Sbjct: 504 QEGKEYIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLEDWR-IWKIIVEL 562 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDF 521 + AL ++HD+C I+H D+KP+N+++ E L DF Sbjct: 563 SLALRFIHDSC--HIVHLDLKPANVMITFEGNLKLGDF 598
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 62.0 bits (149), Expect = 1e-09 Identities = 53/187 (28%), Positives = 85/187 (45%), Gaps = 8/187 (4%) Frame = +3 Query: 75 RAAGSFNASNCIGSGGFGATYKAE-IAPGILVAIKRLAIGRFQG---IQQFQAEVKTLGR 242 R +G + IG GG Y AE I VAIK L I++F+ E ++ Sbjct: 6 RISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRFDYANDNEFIRRFRREAQSASS 65 Query: 243 CRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALA 422 H N+V++ D +++ ++ G L+ +I P+ + I + A+A Sbjct: 66 LDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYIT--ANGPLHPKEALNIMEQIVSAIA 123 Query: 423 YLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWV----SKTTWEFRNSCNHPVSRVLLG 590 + H N +I+HRD+KP NIL+D+ ++DF + S TT NS V Sbjct: 124 HAHQN---QIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHTNSVLGSVH----- 175 Query: 591 YVAPEYA 611 Y++PE A Sbjct: 176 YLSPEQA 182
>CDK3_MOUSE (Q80YP0) Truncated cell division protein kinase 3 homolog| Length = 186 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%) Frame = +3 Query: 108 IGSGGFGATYKAEI-APGILVAIKRLAIG-RFQGIQQFQA-EVKTLGRCRHDNLVTLIGY 278 IG G +G YKA G LVA+K++ + +G+ E+ L +H N++ L+ Sbjct: 10 IGEGTYGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVREISLLKELKHPNIIKLLDV 69 Query: 279 HLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRILH 458 + ++++++ FL +L+R + + ++ + +++ H + R++H Sbjct: 70 VHREKKLYMVFEFLTQ-DLKRHMDSSPTSELPLPVVKSYLAQLLEGVSFCHSH---RVIH 125 Query: 459 RDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAPE 605 RD+KP N+LLD L+DF +++ + H V V L Y APE Sbjct: 126 RDLKPQNLLLDGLGAIKLADFGLARAFGVPLRTYTHEV--VTLWYRAPE 172
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 3/166 (1%) Frame = +3 Query: 54 LTYETVVRAAGSFNASNCIGSGGFGATYKAEIAPGILVAIKRLAIG--RFQGIQQFQAEV 227 ++ + + A+ + SGGFG V +K++ G R + + E Sbjct: 5 MSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEG 64 Query: 228 KTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDV 407 K + R RH +V L+G + + L+ ++ GNL ++ + P+ + +I ++ Sbjct: 65 KMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLK--GRIIVEA 122 Query: 408 ARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWV-SKTTW 542 + YLHD V +H+D+KP NIL+D ++ ++D V S TW Sbjct: 123 IEGMCYLHDKGV---IHKDLKPENILVDRDFHIKIADLGVASFKTW 165
>TGFR2_HUMAN (P37173) TGF-beta receptor type-2 precursor (EC 2.7.11.30)| (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) Length = 567 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/155 (27%), Positives = 77/155 (49%), Gaps = 14/155 (9%) Frame = +3 Query: 108 IGSGGFGATYKAEIAPGILVAIKRLAIGRFQGIQ----QFQAEVKTLGRCRHDNLVTLIG 275 +G G F YKA++ + +A+ F + + + ++ + +H+N++ + Sbjct: 250 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLT 309 Query: 276 YHLSDSEM----FLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCV 443 +E+ +LI F GNL+ ++ T+ I W L K+ +AR +A+LH + Sbjct: 310 AEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGIAHLHSDHT 366 Query: 444 P------RILHRDVKPSNILLDNEYTAYLSDFWVS 530 P I+HRD+K SNIL+ N+ T L DF +S Sbjct: 367 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLS 401
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 62.0 bits (149), Expect = 1e-09 Identities = 56/181 (30%), Positives = 86/181 (47%), Gaps = 9/181 (4%) Frame = +3 Query: 90 FNASNCIGSGGFGATYKAEIA-PGILVAIKRLAIGRFQGIQ-QFQAEVKTLGRCRHDNLV 263 ++ + +G+G F AE LVAIK +A +G + + E+ L + +H N+V Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 264 TLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHKIALDVARALAYLHDNC 440 L + S ++LI + GG L +R ++ K R ++ V A+ YLHD Sbjct: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVE---KGFYTERDASRLIFQVLDAVKYLHD-- 134 Query: 441 VPRILHRDVKPSNIL---LDNEYTAYLSDFWVSKTT---WEFRNSCNHPVSRVLLGYVAP 602 I+HRD+KP N+L LD + +SDF +SK +C P GYVAP Sbjct: 135 -LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTP------GYVAP 187 Query: 603 E 605 E Sbjct: 188 E 188
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/122 (33%), Positives = 64/122 (52%), Gaps = 3/122 (2%) Frame = +3 Query: 249 HDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYL 428 H +++TLI + S S MFL+++ + G L ++ E+ + + I + A+++L Sbjct: 87 HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA--LSEKETRSIMRSLLEAVSFL 144 Query: 429 HDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVS---KTTWEFRNSCNHPVSRVLLGYVA 599 H N I+HRD+KP NILLD+ LSDF S + + R C P GY+A Sbjct: 145 HAN---NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTP------GYLA 195 Query: 600 PE 605 PE Sbjct: 196 PE 197
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/163 (22%), Positives = 81/163 (49%), Gaps = 6/163 (3%) Frame = +3 Query: 51 PLTYETVVRAAGSFNASNCIGSGGFGATYKAEI-----APGILVAIKRLAIGRFQGIQQF 215 P+++++++ F+ IG G Y+ +I A + K++ + + ++F Sbjct: 165 PISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHW--KRF 222 Query: 216 QAEVKTLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNL-ERFIQERTKRPIDWRMLHK 392 +E++ L RH +++ L Y ++ L+Y ++ G L +R P+ W + Sbjct: 223 LSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRIS 282 Query: 393 IALDVARALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDF 521 + + +A+A+ YLH+ ++ +V +NILLD++ L+DF Sbjct: 283 VLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDF 325
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 61.6 bits (148), Expect = 2e-09 Identities = 54/184 (29%), Positives = 92/184 (50%), Gaps = 11/184 (5%) Frame = +3 Query: 87 SFNASNCIGSGGFGATYKAEIAPGI-LVAIKRLAIGRFQGIQQFQAEVKTLGRCRHDNLV 263 S+ + +G+G FG ++A++ P +VAIK++ Q + E++ + + RHDN++ Sbjct: 32 SYTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKV----LQDRRFKNRELQIMRKLRHDNII 87 Query: 264 TLIGYHLSDSE------MFLIYNFLPGG--NLER-FIQERTKRPIDWRMLHKIALDVARA 416 TL + S E + L+ FLP +ER + + + P+++ L+ L R+ Sbjct: 88 TLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYMYQL--LRS 145 Query: 417 LAYLHDNCVPRILHRDVKPSNILLDNEY-TAYLSDFWVSKTTWEFRNSCNHPVSRVLLGY 593 + YLH HRD+KP N+LLD+E L DF +K + ++ SR Y Sbjct: 146 MGYLHSL---GFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYICSRY---Y 199 Query: 594 VAPE 605 APE Sbjct: 200 RAPE 203
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 61.6 bits (148), Expect = 2e-09 Identities = 45/161 (27%), Positives = 75/161 (46%), Gaps = 3/161 (1%) Frame = +3 Query: 60 YETVVRAAGSFNASNCIGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGI--QQFQAEVK 230 + TV ++ N +G G FG A + VAIK++ + ++ E+K Sbjct: 13 FGTVFEITNRYSDLNPVGMGAFGLVCSATDTLTNQQVAIKKIMKPFATAVLAKRTYRELK 72 Query: 231 TLGRCRHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVA 410 L RH+NL+ L LS E L G +L R +Q R P++ + + + Sbjct: 73 LLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTR---PLEKQFVQYFHYQIL 129 Query: 411 RALAYLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSK 533 R L Y+H ++HRD+KPSNIL++ + DF +++ Sbjct: 130 RGLKYVHS---AGVVHRDLKPSNILINENCDLKICDFGLAR 167
>TAO1B_XENLA (Q7ZYJ0) Serine/threonine-protein kinase TAO1-B (EC 2.7.11.1)| (Thousand and one amino acid protein 1-B) Length = 1001 Score = 61.6 bits (148), Expect = 2e-09 Identities = 46/142 (32%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKAEIA-PGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A A +VAIK+++ Q +++Q EVK L R +H N + G Sbjct: 34 IGHGSFGAVYFAHDARTSEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQRIQHPNSIEYKG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + I + LAYLH + ++ Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEIEIAAITHGALQGLAYLHSH---NLI 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRD+K NILL L+DF Sbjct: 149 HRDIKAGNILLTEPGQVKLADF 170
>TAO1A_XENLA (Q6NU21) Serine/threonine-protein kinase TAO1-A (EC 2.7.11.1)| (Thousand and one amino acid protein 1-A) Length = 1001 Score = 61.6 bits (148), Expect = 2e-09 Identities = 45/142 (31%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A + + +VAIK+++ Q +++Q EVK L R +H N + G Sbjct: 34 IGHGSFGAVYFAHDASTREVVAIKKMSYSGKQSNEKWQDIVKEVKFLQRIKHPNSIEYKG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + I + LAYLH + ++ Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEIEIAAITHGALQGLAYLHSH---NLI 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRD+K NILL L+DF Sbjct: 149 HRDIKAGNILLTEPGQVKLADF 170
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 61.6 bits (148), Expect = 2e-09 Identities = 44/142 (30%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A ++ +VAIK+++ Q +++Q EV+ L + RH N + G Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + + + LAYLH + ++ Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEVEIAAVTHGALQGLAYLHSH---NMI 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRDVK NILL L DF Sbjct: 149 HRDVKAGNILLSEPGLVKLGDF 170
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 61.6 bits (148), Expect = 2e-09 Identities = 44/142 (30%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 108 IGSGGFGATYKA-EIAPGILVAIKRLAIGRFQGIQQFQ---AEVKTLGRCRHDNLVTLIG 275 IG G FGA Y A ++ +VAIK+++ Q +++Q EV+ L + RH N + G Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 93 Query: 276 YHLSDSEMFLIYNFLPGGNLERFIQERTKRPIDWRMLHKIALDVARALAYLHDNCVPRIL 455 +L + +L+ + G + + E K+P+ + + + LAYLH + ++ Sbjct: 94 CYLREHTAWLVMEYCLGSASD--LLEVHKKPLQEVEIAAVTHGALQGLAYLHSH---NMI 148 Query: 456 HRDVKPSNILLDNEYTAYLSDF 521 HRDVK NILL L DF Sbjct: 149 HRDVKAGNILLSEPGLVKLGDF 170
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 61.6 bits (148), Expect = 2e-09 Identities = 44/181 (24%), Positives = 91/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 72 VRAAGSFNASNCIGSGGFGATYKAEI-APGILVAIKRLAIGRFQGIQQFQA-EVKTLGRC 245 + + F +G G + YK G LVA+K + + +G E+ + Sbjct: 1 MNTSSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIREISLMKEL 60 Query: 246 RHDNLVTLIGYHLSDSEMFLIYNFLPGGNLERFIQER-TKRPIDWRMLHKIALDVARALA 422 +H+N+VTL +++++ L++ ++ +L++F+ K ++ + + + R + Sbjct: 61 KHENIVTLYDVIHTENKLNLVFEYMDK-DLKKFMDTNGNKGALETKQVKWFMYQLLRGIL 119 Query: 423 YLHDNCVPRILHRDVKPSNILLDNEYTAYLSDFWVSKTTWEFRNSCNHPVSRVLLGYVAP 602 + HDN R+LHRD+KP N+L++ + L+DF +++ N+ ++ V V L Y AP Sbjct: 120 FCHDN---RVLHRDLKPQNLLINAKGQLKLADFGLARAFGIPVNTFSNEV--VTLWYRAP 174 Query: 603 E 605 + Sbjct: 175 D 175 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 95,916,258 Number of Sequences: 219361 Number of extensions: 2115090 Number of successful extensions: 9394 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7990 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8471 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5538924943 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
