ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd12m19 |
|---|---|
| Clone Library Name | barley_pub |
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 129 bits (325), Expect = 5e-30 Identities = 71/152 (46%), Positives = 97/152 (63%) Frame = +3 Query: 168 TSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINE 347 TS RY++ E+ K R+FK +LG+G G+VYKG L + VAVK LE+ E F E Sbjct: 518 TSNFRRYSYRELVKATRKFKVELGRGESGTVYKGVLEDDRHVAVKKLENVRQGKEVFQAE 577 Query: 348 VATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLD 527 ++ IG I+H N+VR+ GFCSEG+ R L+ EY+ N SL +FS NI LL + Sbjct: 578 LSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNI---LLDWEGRFN 634 Query: 528 IALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IALG+A+G+ YLH C + ++H D+KP NILL Sbjct: 635 IALGVAKGLAYLHHECLEWVIHCDVKPENILL 666
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 117 bits (292), Expect = 4e-26 Identities = 62/133 (46%), Positives = 85/133 (63%), Gaps = 1/133 (0%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFC 404 +KLGQGGFG VYKG L +G +AVK L ++ +G +EF+NEV I + H N+V+++G C Sbjct: 532 NKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCC 591 Query: 405 SEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQR 584 EG + LIYEY+ N SL+ Y+F + L + DI G+ARG+ YLHQ R Sbjct: 592 IEGDEKMLIYEYLENLSLDSYLF---GKTRRSKLNWNERFDITNGVARGLLYLHQDSRFR 648 Query: 585 ILHFDIKPHNILL 623 I+H D+K NILL Sbjct: 649 IIHRDLKVSNILL 661
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 114 bits (286), Expect = 2e-25 Identities = 64/147 (43%), Positives = 89/147 (60%), Gaps = 1/147 (0%) Frame = +3 Query: 186 YTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEG-EEFINEVATIG 362 + + EV I F+ +G+GGFG VY G + NG VAVK+L + +G +EF EV + Sbjct: 564 FKYSEVVNITNNFERVIGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDLLM 622 Query: 363 LIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGI 542 +HH N+ L+G+C+E LIYEYM NE+L Y+ S I L+ + L I+L Sbjct: 623 RVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFI----LSWEERLKISLDA 678 Query: 543 ARGMEYLHQGCNQRILHFDIKPHNILL 623 A+G+EYLH GC I+H D+KP NILL Sbjct: 679 AQGLEYLHNGCKPPIVHRDVKPTNILL 705
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 113 bits (282), Expect = 5e-25 Identities = 58/133 (43%), Positives = 85/133 (63%), Gaps = 3/133 (2%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE---EFINEVATIGLIHHANIVRLMGFC 404 LG GGFG VYKGEL +G +AVK +E+ G+ EF +E+A + + H ++V L+G+C Sbjct: 594 LGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYC 653 Query: 405 SEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQR 584 +G + L+YEYMP +L +++F S K L + L +AL +ARG+EYLH +Q Sbjct: 654 LDGNEKLLVYEYMPQGTLSRHLFEW-SEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQS 712 Query: 585 ILHFDIKPHNILL 623 +H D+KP NILL Sbjct: 713 FIHRDLKPSNILL 725
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 111 bits (277), Expect = 2e-24 Identities = 64/154 (41%), Positives = 92/154 (59%), Gaps = 4/154 (2%) Frame = +3 Query: 174 KPTRYTFPEVKKIARRFKDK--LGQGGFGSVYKGELRN-GVPVAVKMLESSTGEG-EEFI 341 K +TF E+ + F+ LG+GGFG V+KG + VA+K L+ + +G EF+ Sbjct: 87 KAQTFTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFV 146 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 EV T+ L H N+V+L+GFC+EG +R L+YEYMP SLE ++ HV +K L Sbjct: 147 VEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHL--HVLPSGKKPLDWNTR 204 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + IA G ARG+EYLH +++ D+K NILL Sbjct: 205 MKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILL 238
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 111 bits (277), Expect = 2e-24 Identities = 63/163 (38%), Positives = 99/163 (60%), Gaps = 1/163 (0%) Frame = +3 Query: 138 KVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESS 317 K + F+K+ KP +T +++ ++K +G+GGFGSVY+G L +G VAVK+ S+ Sbjct: 573 KDDFFIKSVSV-KP--FTLEYIEQATEQYKTLIGEGGFGSVYRGTLDDGQEVAVKVRSST 629 Query: 318 TGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNIS 494 + +G EF NE+ + I H N+V L+G+C+E ++ L+Y +M N SL ++ S Sbjct: 630 STQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEAS--K 687 Query: 495 QKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +K+L L IALG ARG+ YLH + ++H D+K NILL Sbjct: 688 RKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILL 730
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 110 bits (274), Expect = 4e-24 Identities = 65/154 (42%), Positives = 87/154 (56%), Gaps = 4/154 (2%) Frame = +3 Query: 174 KPTR-YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFI 341 KP R TF + + F + +G GGFG VYK +LR+G VA+K L TG+G+ EF+ Sbjct: 842 KPLRKLTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFM 901 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 E+ TIG I H N+V L+G+C G R L+YEYM SLE + S L Sbjct: 902 AEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAAR 961 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IA+G ARG+ +LH C I+H D+K N+LL Sbjct: 962 KKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLL 995
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 108 bits (271), Expect = 1e-23 Identities = 65/154 (42%), Positives = 90/154 (58%), Gaps = 4/154 (2%) Frame = +3 Query: 174 KPTR-YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFI 341 KP R TF ++ + F + +G GGFG VYK +L++G VA+K L +G+G+ EF Sbjct: 871 KPLRKLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFT 930 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 E+ TIG I H N+V L+G+C G R L+YEYM SLE + I KL P + Sbjct: 931 AEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDR-KKIGIKLNWPARR 989 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IA+G ARG+ +LH C I+H D+K N+LL Sbjct: 990 -KIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLL 1022
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 107 bits (267), Expect = 3e-23 Identities = 61/163 (37%), Positives = 98/163 (60%), Gaps = 1/163 (0%) Frame = +3 Query: 138 KVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESS 317 K + F+K+ KP +T ++ ++K +G+GGFGSVY+G L +G VAVK+ ++ Sbjct: 572 KDDFFIKSVSV-KP--FTLEYIELATEKYKTLIGEGGFGSVYRGTLDDGQEVAVKVRSAT 628 Query: 318 TGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNIS 494 + +G EF NE+ + I H N+V L+G+C+E ++ L+Y +M N SL ++ + Sbjct: 629 STQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPA--K 686 Query: 495 QKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +K+L L IALG ARG+ YLH + ++H D+K NILL Sbjct: 687 RKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILL 729
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 107 bits (267), Expect = 3e-23 Identities = 65/151 (43%), Positives = 86/151 (56%), Gaps = 4/151 (2%) Frame = +3 Query: 183 RYTFPEVKKIARRFKDK--LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE--FINEV 350 R++ E++ + F +K LG+GGFG VYKG L +G VAVK L+ +G E F EV Sbjct: 276 RFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEV 335 Query: 351 ATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDI 530 I + H N++RL GFC T R L+Y YM N S+ + SQ L K I Sbjct: 336 EMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPE--SQPPLDWPKRQRI 393 Query: 531 ALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 ALG ARG+ YLH C+ +I+H D+K NILL Sbjct: 394 ALGSARGLAYLHDHCDPKIIHRDVKAANILL 424
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 107 bits (266), Expect = 4e-23 Identities = 64/154 (41%), Positives = 89/154 (57%), Gaps = 4/154 (2%) Frame = +3 Query: 174 KPTR-YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFI 341 KP R TF ++ + F + +G GGFG VYK +L++G VA+K L +G+G+ EF Sbjct: 871 KPLRKLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFT 930 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 E+ TIG I H N+V L+G+C G R L+YEYM SLE + KL P + Sbjct: 931 AEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDR-KKTGIKLNWPARR 989 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IA+G ARG+ +LH C I+H D+K N+LL Sbjct: 990 -KIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLL 1022
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 105 bits (261), Expect = 1e-22 Identities = 63/154 (40%), Positives = 90/154 (58%), Gaps = 4/154 (2%) Frame = +3 Query: 174 KPTR-YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFI 341 KP R TF ++ + F + +G GGFG VYK L++G VA+K L +G+G+ EF+ Sbjct: 866 KPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFM 925 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 E+ TIG I H N+V L+G+C G R L+YE+M SLE + KL T+ Sbjct: 926 AEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLED-VLHDPKKAGVKLNWSTRR 984 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IA+G ARG+ +LH C+ I+H D+K N+LL Sbjct: 985 -KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLL 1017
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 105 bits (261), Expect = 1e-22 Identities = 63/154 (40%), Positives = 85/154 (55%), Gaps = 4/154 (2%) Frame = +3 Query: 174 KPTR-YTFPEVKKIARRFK--DKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFI 341 KP R TF + + F +G GGFG VYK +L +G VA+K L TG+G+ EF+ Sbjct: 841 KPLRKLTFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFM 900 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 E+ TIG I H N+V L+G+C G R L+YEYM SLE + L + Sbjct: 901 AEMETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKK-GGIFLDWSAR 959 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IA+G ARG+ +LH C I+H D+K N+LL Sbjct: 960 KKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLL 993
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 104 bits (260), Expect = 2e-22 Identities = 65/177 (36%), Positives = 98/177 (55%), Gaps = 4/177 (2%) Frame = +3 Query: 105 LKSKYNEEINKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDK--LGQGGFGSVYKGELR 278 L SK N +++ + G + F E+ F LG+GGFG VYKG L Sbjct: 47 LSSKTNGGSKRELLLPRDGLGQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLD 106 Query: 279 N-GVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 452 + G VAVK L+ + +G EF+ EV + L+HH N+V L+G+C++G +R L+YE+MP Sbjct: 107 STGQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLG 166 Query: 453 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 SLE ++ H ++ L + IA G A+G+E+LH N +++ D K NILL Sbjct: 167 SLEDHL--HDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILL 221
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 103 bits (258), Expect = 3e-22 Identities = 62/131 (47%), Positives = 75/131 (57%), Gaps = 1/131 (0%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSE 410 +G GGFG VYK L +G VA+K L G+ E EF EV T+ H N+V L GFC Sbjct: 740 IGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFY 799 Query: 411 GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 590 R LIY YM N SL+ ++ H N LL L IA G A+G+ YLH+GC+ IL Sbjct: 800 KNDRLLIYSYMENGSLDYWL--HERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHIL 857 Query: 591 HFDIKPHNILL 623 H DIK NILL Sbjct: 858 HRDIKSSNILL 868
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 103 bits (257), Expect = 4e-22 Identities = 58/134 (43%), Positives = 83/134 (61%), Gaps = 1/134 (0%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVPVAVKML-ESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 K+ +G GGFG+VYK L VAVK L E+ T EF+ E+ T+G + H N+V L+G+ Sbjct: 920 KNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGY 979 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 CS + L+YEYM N SL+ ++ + + ++L +K L IA+G ARG+ +LH G Sbjct: 980 CSFSEEKLLVYEYMVNGSLDHWLRNQTGML--EVLDWSKRLKIAVGAARGLAFLHHGFIP 1037 Query: 582 RILHFDIKPHNILL 623 I+H DIK NILL Sbjct: 1038 HIIHRDIKASNILL 1051
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 100 bits (248), Expect = 5e-21 Identities = 58/131 (44%), Positives = 73/131 (55%), Gaps = 1/131 (0%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSE 410 +G GGFG VYK L +G VA+K L TG+ + EF EV T+ H N+V L+G+C+ Sbjct: 749 IGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNY 808 Query: 411 GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 590 + LIY YM N SL+ ++ V L L IA G A G+ YLHQ C IL Sbjct: 809 KNDKLLIYSYMDNGSLDYWLHEKVD--GPPSLDWKTRLRIARGAAEGLAYLHQSCEPHIL 866 Query: 591 HFDIKPHNILL 623 H DIK NILL Sbjct: 867 HRDIKSSNILL 877
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 99.8 bits (247), Expect = 6e-21 Identities = 51/131 (38%), Positives = 80/131 (61%), Gaps = 1/131 (0%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSE 410 +G GGFG V+K L++G VA+K L + +G+ EF+ E+ T+G I H N+V L+G+C Sbjct: 844 IGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKI 903 Query: 411 GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 590 G R L+YE+M SLE+ + + +++L + IA G A+G+ +LH C I+ Sbjct: 904 GEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHII 963 Query: 591 HFDIKPHNILL 623 H D+K N+LL Sbjct: 964 HRDMKSSNVLL 974
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 99.4 bits (246), Expect = 8e-21 Identities = 61/159 (38%), Positives = 89/159 (55%), Gaps = 13/159 (8%) Frame = +3 Query: 186 YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRN----------GVPVAVKMLESSTGEG 329 +TF E+K R F+ LG+GGFGSV+KG + GV +AVK L +G Sbjct: 57 FTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGWQG 116 Query: 330 -EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL 506 +E++ EV +G H N+V+L+G+C E R L+YE+MP SLE ++F S L Sbjct: 117 HQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQP--L 174 Query: 507 APTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + T L +ALG A+G+ +LH +++ D K NILL Sbjct: 175 SWTLRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILL 212
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 95.9 bits (237), Expect = 9e-20 Identities = 61/144 (42%), Positives = 75/144 (52%), Gaps = 11/144 (7%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE-----------FINEVATIGLIH 371 K+ +G G G VYK ELR G VAVK L S G++ F EV T+G I Sbjct: 686 KNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIR 745 Query: 372 HANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARG 551 H +IVRL CS G + L+YEYMPN SL + H +L + L IAL A G Sbjct: 746 HKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVL--HGDRKGGVVLGWPERLRIALDAAEG 803 Query: 552 MEYLHQGCNQRILHFDIKPHNILL 623 + YLH C I+H D+K NILL Sbjct: 804 LSYLHHDCVPPIVHRDVKSSNILL 827
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 95.1 bits (235), Expect = 1e-19 Identities = 53/169 (31%), Positives = 99/169 (58%), Gaps = 5/169 (2%) Frame = +3 Query: 132 NKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKD--KLGQGGFGSVYKGELRNGVPVAVKM 305 N K++ ++ + +++ E+++ F + ++G+G F V+KG LR+G VAVK Sbjct: 475 NMKIQPDMEDLKIRRAQEFSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKR 534 Query: 306 LESSTG---EGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 476 ++ +EF NE+ + ++HA+++ L+G+C +G+ R L+YE+M + SL +++ Sbjct: 535 AIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHG 594 Query: 477 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 N+ +K L + + IA+ ARG+EYLH ++H DIK NIL+ Sbjct: 595 KDPNL-KKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI 642
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 93.2 bits (230), Expect = 6e-19 Identities = 56/159 (35%), Positives = 87/159 (54%), Gaps = 13/159 (8%) Frame = +3 Query: 186 YTFPEVKKIARRFK--DKLGQGGFGSVYKG----------ELRNGVPVAVKMLESSTGEG 329 Y F ++K + FK LGQGGFG VY+G + +G+ VA+K L S + +G Sbjct: 74 YNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQG 133 Query: 330 -EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL 506 E+ +EV +G++ H N+V+L+G+C E L+YE+MP SLE ++F L Sbjct: 134 FAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRNDPFPWDL- 192 Query: 507 APTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + I +G ARG+ +LH + +++ D K NILL Sbjct: 193 ----RIKIVIGAARGLAFLH-SLQREVIYRDFKASNILL 226
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/162 (35%), Positives = 90/162 (55%), Gaps = 16/162 (9%) Frame = +3 Query: 186 YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRN----------GVPVAVKMLESSTGEG 329 ++F E+K R F+ LG+GGFG V+KG + G+ +AVK L +G Sbjct: 56 FSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQDGWQG 115 Query: 330 -EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS---HVSNISQ 497 +E++ EV +G H ++V+L+G+C E R L+YE+MP SLE ++F + +S Sbjct: 116 HQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYFQPLSW 175 Query: 498 KLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 KL L +ALG A+G+ +LH R+++ D K NILL Sbjct: 176 KL-----RLKVALGAAKGLAFLHSS-ETRVIYRDFKTSNILL 211
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 88.2 bits (217), Expect = 2e-17 Identities = 54/132 (40%), Positives = 76/132 (57%), Gaps = 2/132 (1%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLES-STGEGEE-FINEVATIGLIHHANIVRLMGFCS 407 +G+GG G VY+G + N V VA+K L TG + F E+ T+G I H +IVRL+G+ + Sbjct: 698 IGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVA 757 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 L+YEYMPN SL + + H S L +A+ A+G+ YLH C+ I Sbjct: 758 NKDTNLLLYEYMPNGSLGELL--HGSKGGH--LQWETRHRVAVEAAKGLCYLHHDCSPLI 813 Query: 588 LHFDIKPHNILL 623 LH D+K +NILL Sbjct: 814 LHRDVKSNNILL 825
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 85.9 bits (211), Expect = 9e-17 Identities = 52/159 (32%), Positives = 87/159 (54%), Gaps = 8/159 (5%) Frame = +3 Query: 171 SKPTRYTFP--EVKKIARRFKD--KLGQGGFGSVYKGELRNGVPVAVKMLESS----TGE 326 ++P + +P E+ + F + K+G+GGFG VY+ +RN V ++ E++ T Sbjct: 193 ARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAV 252 Query: 327 GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL 506 + F+ EV + H NIV G+C++ L+Y ++PN SLE + H + L Sbjct: 253 KQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL--HCQTQACPPL 310 Query: 507 APTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + + LDI LG AR +++LHQ + ++H DIK N+LL Sbjct: 311 SWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLL 348
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 85.5 bits (210), Expect = 1e-16 Identities = 54/159 (33%), Positives = 87/159 (54%), Gaps = 13/159 (8%) Frame = +3 Query: 186 YTFPEVKKIARRFKDK--LGQGGFGSVYKGELRN----------GVPVAVKMLESSTGEG 329 ++ E+K R F+ +G+GGFG V+KG + G+ +AVK L +G Sbjct: 56 FSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQG 115 Query: 330 E-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL 506 E++ E+ +G + H N+V+L+G+C E R L+YE+M SLE ++F Q L Sbjct: 116 HREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRR-GTFYQPLS 174 Query: 507 APTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 T+ + +ALG ARG+ +LH ++++ D K NILL Sbjct: 175 WNTR-VRMALGAARGLAFLH-NAQPQVIYRDFKASNILL 211
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 85.1 bits (209), Expect = 2e-16 Identities = 55/156 (35%), Positives = 84/156 (53%), Gaps = 7/156 (4%) Frame = +3 Query: 177 PTRYTFPEVKKIARRFKDKL--GQGGFGSVYKGELRNGVPVAVKMLESS-----TGEGEE 335 P + F E+ + F ++L G+GGFG VY+ +RN AVK L+ T + Sbjct: 197 PFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRN-TTYAVKRLKEEADLEWTMVKQS 255 Query: 336 FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPT 515 F+ EV + H NIV G+C+E L+Y ++PN SLE + H+ + L+ Sbjct: 256 FLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQL--HLQTQACSPLSWP 313 Query: 516 KMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + LDI LG AR +++LHQ + ++H DIK N+LL Sbjct: 314 QRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLL 348
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 82.4 bits (202), Expect = 1e-15 Identities = 48/139 (34%), Positives = 77/139 (55%), Gaps = 7/139 (5%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVAVKML-------ESSTGEGEEFINEVATIGLIHHANIV 386 ++LGQGGFG VY+G+ + + VA+K++ + E ++ NE+ + I H NI+ Sbjct: 217 NRLGQGGFGDVYRGKWKQ-LDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNIL 275 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLH 566 L G+ +G + L+Y+ M SLE + +H + L + I+LG ARG+ +LH Sbjct: 276 ALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLH 335 Query: 567 QGCNQRILHFDIKPHNILL 623 ++H DIKP NILL Sbjct: 336 TARGTPLIHGDIKPANILL 354
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 77.8 bits (190), Expect = 2e-14 Identities = 57/160 (35%), Positives = 84/160 (52%), Gaps = 14/160 (8%) Frame = +3 Query: 186 YTFPEVKKIARRFKD--------KLGQGGFGSVYKGELRNGVPVAVK----MLESSTGE- 326 ++F E+K I F + ++G+GGFG VYKG + N + VAVK M+E ST E Sbjct: 168 FSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNNTI-VAVKKLGAMVEISTEEL 226 Query: 327 GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNI-SQKL 503 ++F E+ + H N+V L+GF S+ L+Y YMPN SL +S + Sbjct: 227 KQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSL----LDRLSCLDGTPP 282 Query: 504 LAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L+ +A G A G+ +LH+ + +H DIK NILL Sbjct: 283 LSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILL 319
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 77.0 bits (188), Expect = 4e-14 Identities = 57/160 (35%), Positives = 84/160 (52%), Gaps = 14/160 (8%) Frame = +3 Query: 186 YTFPEVKKIARRFKD--------KLGQGGFGSVYKGELRNGVPVAVK----MLESSTGE- 326 ++F E+K + F + K+G+GGFG VYKG + N VAVK M++ +T E Sbjct: 168 FSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNN-TTVAVKKLAAMVDITTEEL 226 Query: 327 GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNI-SQKL 503 ++F E+ + H N+V L+GF S+G L+Y YMPN SL +S + Sbjct: 227 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSL----LDRLSCLDGTPP 282 Query: 504 LAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L+ IA G A G+ +LH+ + +H DIK NILL Sbjct: 283 LSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILL 319
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 75.9 bits (185), Expect = 9e-14 Identities = 49/137 (35%), Positives = 79/137 (57%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKGE-LRNG----VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRL 392 LG G FG+VYKG + G +PVA+K+L +TG EF++E + + H ++VRL Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRL 783 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + L+ + MP+ L +Y+ H NI +LL L+ + IA+GM YL + Sbjct: 784 LGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLL-----LNWCVQIAKGMMYLEE- 836 Query: 573 CNQRILHFDIKPHNILL 623 +R++H D+ N+L+ Sbjct: 837 --RRLVHRDLAARNVLV 851
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/137 (35%), Positives = 79/137 (57%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKGE-LRNG----VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRL 392 LG G FG+VYKG + G +PVA+K+L +TG EF++E + + H ++VRL Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + L+ + MP+ L +Y+ H NI +LL L+ + IA+GM YL + Sbjct: 784 LGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLL-----LNWCVQIAKGMMYLEE- 836 Query: 573 CNQRILHFDIKPHNILL 623 +R++H D+ N+L+ Sbjct: 837 --RRLVHRDLAARNVLV 851
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 74.3 bits (181), Expect = 3e-13 Identities = 50/146 (34%), Positives = 74/146 (50%), Gaps = 4/146 (2%) Frame = +3 Query: 198 EVKKIARRFKDK--LGQGGFGSVYKGELRNGVPVAVKMLESS--TGEGEEFINEVATIGL 365 +V + DK +G+G G++YK L AVK L + + E+ TIG Sbjct: 808 KVLEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGK 867 Query: 366 IHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIA 545 + H N+++L F ++Y YM N SL + H +N + L T+ +IA+G A Sbjct: 868 VRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDIL--HETNPPKPLDWSTRH-NIAVGTA 924 Query: 546 RGMEYLHQGCNQRILHFDIKPHNILL 623 G+ YLH C+ I+H DIKP NILL Sbjct: 925 HGLAYLHFDCDPAIVHRDIKPMNILL 950
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 73.9 bits (180), Expect = 3e-13 Identities = 41/142 (28%), Positives = 73/142 (51%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + ++LG G FG V +G+ R + AVKM++ T ++FI E + + H Sbjct: 520 EIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHP 579 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 N+V+L G CS+ ++ EYM + SL Y+ H + + +LD+ + +++GM Sbjct: 580 NLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMT 636 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL + +H D+ N L+ Sbjct: 637 YLER---HNYIHRDLAARNCLV 655
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 73.6 bits (179), Expect = 5e-13 Identities = 46/151 (30%), Positives = 79/151 (52%), Gaps = 2/151 (1%) Frame = +3 Query: 177 PTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVAT 356 P + E+ + +++G+G FGSV++ + VA KML+SS E E+F+ E Sbjct: 207 PVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREKFVLEAKI 266 Query: 357 IGLIHHANIVRLMGFCSE--GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDI 530 + + H IV L+G C+E +I EYM N SL++Y+ K +M+ + Sbjct: 267 MHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYL----KTPDGKKTNLNQMVHM 322 Query: 531 ALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 I+ GM YL +++++H D++ NIL+ Sbjct: 323 MAEISEGMAYLE---SEKVVHRDLRADNILV 350
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 73.2 bits (178), Expect = 6e-13 Identities = 48/153 (31%), Positives = 82/153 (53%) Frame = +3 Query: 165 GTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFIN 344 G S TR + E+ + + +F KLG G FG V++G N PVA+K L+S T + ++F+ Sbjct: 232 GLSHRTRDQW-EIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLA 290 Query: 345 EVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKML 524 E + + H +++L C+ +I E M + SL +Y+ ++ + L T ++ Sbjct: 291 EAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYL-QAIAGKGRSLKMQT-LI 348 Query: 525 DIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 D+A IA GM YL +Q +H D+ N+L+ Sbjct: 349 DMAAQIAAGMAYLE---SQNYIHRDLAARNVLV 378
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/136 (36%), Positives = 76/136 (55%), Gaps = 3/136 (2%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE---EFINEVATIGLIHHANIVRLM 395 K+K+G G FG+V++ E +G VAVK+L E EF+ EVA + + H NIV M Sbjct: 554 KEKIGAGSFGTVHRAEW-HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFM 612 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ +++ EY+ SL Y H S +++ L + L +A +A+GM YLH Sbjct: 613 GAVTQPPNLSIVTEYLSRGSL--YRLLHKSG-AREQLDERRRLSMAYDVAKGMNYLHNR- 668 Query: 576 NQRILHFDIKPHNILL 623 N I+H D+K N+L+ Sbjct: 669 NPPIVHRDLKSPNLLV 684
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/184 (28%), Positives = 93/184 (50%), Gaps = 8/184 (4%) Frame = +3 Query: 96 YLSLKS---KYNEEINKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYK 266 Y+S+ S K +K ++ L G E++ F + +G G FG VYK Sbjct: 526 YVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIE-----FHEIIGSGSFGKVYK 580 Query: 267 GELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMGFC-SEGTRRALI 431 G RN + VA+K ++T + + F EV+ + ++H +++ +G C ++ ++ A++ Sbjct: 581 GRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 639 Query: 432 YEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPH 611 +Y+ SL + +++L L IA+ +A+GMEYLH Q I+H D+ H Sbjct: 640 TQYISGGSLFSLLHE-----QKRILDLQSKLIIAVDVAKGMEYLH-NLTQPIIHRDLNSH 693 Query: 612 NILL 623 NILL Sbjct: 694 NILL 697
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 72.0 bits (175), Expect = 1e-12 Identities = 46/139 (33%), Positives = 77/139 (55%), Gaps = 5/139 (3%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVR 389 F + +G G FG VYKG RN + VA+K ++T + + F EV+ + ++H +V+ Sbjct: 464 FHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQ 522 Query: 390 LMGFC-SEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLH 566 +G C + ++ A++ +Y+ SL + +++L L IA+ +A+GMEYLH Sbjct: 523 FVGACLDDPSQFAIVTQYISGGSLFSLLHE-----QKRILDLQSKLIIAVDVAKGMEYLH 577 Query: 567 QGCNQRILHFDIKPHNILL 623 Q I+H D+ HNILL Sbjct: 578 -SLTQPIIHRDLNSHNILL 595
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 72.0 bits (175), Expect = 1e-12 Identities = 46/139 (33%), Positives = 77/139 (55%), Gaps = 5/139 (3%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVR 389 F + +G G FG VYKG RN + VA+K ++T + + F EV+ + ++H +V+ Sbjct: 463 FHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQ 521 Query: 390 LMGFC-SEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLH 566 +G C + ++ A++ +Y+ SL + +++L L IA+ +A+GMEYLH Sbjct: 522 FVGACLDDPSQFAIVTQYISGGSLFSLLHE-----QKRILDLQSKLIIAVDVAKGMEYLH 576 Query: 567 QGCNQRILHFDIKPHNILL 623 Q I+H D+ HNILL Sbjct: 577 -SLTQPIIHRDLNSHNILL 594
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 71.6 bits (174), Expect = 2e-12 Identities = 46/128 (35%), Positives = 72/128 (56%), Gaps = 3/128 (2%) Frame = +3 Query: 249 FGSVYKGELRNGVPVAVKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTR-- 419 +G+VYK +L +G +A+++L T + + + +G I H N+V L F +G R Sbjct: 384 YGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFY-QGKRGE 442 Query: 420 RALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFD 599 + LIY+Y+PN SL + H S + L + IALGIARG+ YLH G I+H + Sbjct: 443 KLLIYDYLPNISLHDLL--HESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGN 500 Query: 600 IKPHNILL 623 I+ N+L+ Sbjct: 501 IRSKNVLV 508
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 71.6 bits (174), Expect = 2e-12 Identities = 46/140 (32%), Positives = 75/140 (53%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGEL----RNGVPVAVKMLE--SSTGEGEEFINEVATIGLIHHANI 383 F ++LG+G FG VYKG+L + + VA+K L+ +S ++F E+ I + H NI Sbjct: 412 FLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNI 471 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 V ++G +++EYM N L +++ S+ S K L+ + L IAL I+ GM+YL Sbjct: 472 VCILGVVLNKEPYCMLFEYMANGDLHEFLISN-SPTEGKSLSQLEFLQIALQISEGMQYL 530 Query: 564 HQGCNQRILHFDIKPHNILL 623 +H D+ N L+ Sbjct: 531 SA---HHYVHRDLAARNCLV 547
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 71.2 bits (173), Expect = 2e-12 Identities = 57/166 (34%), Positives = 77/166 (46%), Gaps = 8/166 (4%) Frame = +3 Query: 150 FLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGEL-----RNGVPVAVKMLES 314 F A+ PT++ +K F +LG+G FGSV G VAVK L+ Sbjct: 832 FSGAFEDRDPTQFEERHLK-----FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH 886 Query: 315 STGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRR--ALIYEYMPNESLEKYIFSHVS 485 ST E +F E+ + + H NIV+ G C RR LI EY+P SL Y+ H Sbjct: 887 STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKE 946 Query: 486 NISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 I K K+L I +GMEYL +R +H D+ NIL+ Sbjct: 947 RIDHK-----KLLQYTSQICKGMEYLG---TKRYIHRDLATRNILV 984 Score = 43.5 bits (101), Expect = 5e-04 Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 9/143 (6%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELR--------NGVPVAVKMLESS-TGEGEEFINEVATIGLIHH 374 F + LGQG F ++KG R + V +K+L+ + E F + + + H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSH 606 Query: 375 ANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGM 554 ++V G C G L+ E++ SL+ Y+ + ++I+ L +A +A M Sbjct: 607 KHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSIN-----ILWKLGVAKQLAWAM 661 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 +L + + ++H ++ NILL Sbjct: 662 HFLEE---KSLIHGNVCAKNILL 681
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 71.2 bits (173), Expect = 2e-12 Identities = 57/166 (34%), Positives = 77/166 (46%), Gaps = 8/166 (4%) Frame = +3 Query: 150 FLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGEL-----RNGVPVAVKMLES 314 F A+ PT++ +K F +LG+G FGSV G VAVK L+ Sbjct: 832 FSGAFEDRDPTQFEERHLK-----FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH 886 Query: 315 STGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRR--ALIYEYMPNESLEKYIFSHVS 485 ST E +F E+ + + H NIV+ G C RR LI EY+P SL Y+ H Sbjct: 887 STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKE 946 Query: 486 NISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 I K K+L I +GMEYL +R +H D+ NIL+ Sbjct: 947 RIDHK-----KLLQYTSQICKGMEYLG---TKRYIHRDLATRNILV 984 Score = 43.5 bits (101), Expect = 5e-04 Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 9/143 (6%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELR--------NGVPVAVKMLESS-TGEGEEFINEVATIGLIHH 374 F + LGQG F ++KG R + V +K+L+ + E F + + + H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSH 606 Query: 375 ANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGM 554 ++V G C G L+ E++ SL+ Y+ + ++I+ L +A +A M Sbjct: 607 KHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSIN-----ILWKLGVAKQLAWAM 661 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 +L + + ++H ++ NILL Sbjct: 662 HFLEE---KSLIHGNVCAKNILL 681
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNG-----VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRL 392 +G G FG VYKG L+ VPVA+K L++ E + +F+ E +G H NI+RL Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 678 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 G S+ +I EYM N +L+K++ S +++ + GIA GM+YL Sbjct: 679 EGVISKYKPMMIITEYMENGALDKFLREKDGEFS-----VLQLVGMLRGIAAGMKYL--- 730 Query: 573 CNQRILHFDIKPHNILL 623 N +H D+ NIL+ Sbjct: 731 ANMNYVHRDLAARNILV 747
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+++ + + + F NEVA + H NI+ MG+ + Sbjct: 354 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMT 413 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL K++ HV ++ +++DIA A+GM+YLH + I Sbjct: 414 K-DNLAIVTQWCEGSSLYKHL--HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNI 464 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 465 IHRDMKSNNIFL 476
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 70.1 bits (170), Expect = 5e-12 Identities = 44/142 (30%), Positives = 72/142 (50%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + + KLGQG FG V+ G VAVK L+ T E ++F+ E + IHH Sbjct: 60 EIDRTTIQLQRKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTMEVKDFVQEAQVMKKIHHP 119 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 N+++L C+ G ++ E M S+ +Y+ + K + +M+D++ IA GM Sbjct: 120 NLLQLYAVCTIGEPIYIVTELMKYGSMLEYL----KHGEGKNITLHQMVDMSAQIASGMT 175 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL +H D+ NIL+ Sbjct: 176 YLEA---HSYIHRDLAARNILV 194
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+++ + + + F NEVA + H NI+ MG+ + Sbjct: 87 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMT 146 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL K++ HV ++ +++DIA A+GM+YLH + I Sbjct: 147 K-DNLAIVTQWCEGSSLYKHL--HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNI 197 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 198 IHRDMKSNNIFL 209
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+++ + + + F NEVA + H NI+ MG+ + Sbjct: 354 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMT 413 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL K++ HV ++ +++DIA A+GM+YLH + I Sbjct: 414 K-DNLAIVTQWCEGSSLYKHL--HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNI 464 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 465 IHRDMKSNNIFL 476
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 70.1 bits (170), Expect = 5e-12 Identities = 47/140 (33%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE----FINEVATIGLIHHANIVR 389 F +G+G FG V +G R VA+K++ + + F NEV + + H N+V+ Sbjct: 1291 FGQTIGKGFFGEVKRGYWRE-TDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQ 1349 Query: 390 LMGFCSEG--TRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 +G C+ G ++ E+M SL +++ H + + Q P L +AL IA+GM YL Sbjct: 1350 FLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQN---PHIRLKLALDIAKGMNYL 1406 Query: 564 HQGCNQRILHFDIKPHNILL 623 H G ILH D+ NILL Sbjct: 1407 H-GWTPPILHRDLSSRNILL 1425
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 70.1 bits (170), Expect = 5e-12 Identities = 45/133 (33%), Positives = 70/133 (52%), Gaps = 1/133 (0%) Frame = +3 Query: 228 DKLGQGGFGSVYKGEL-RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFC 404 +KLG G +G VY+G R+ +AVK L+ EF+ E A + +HH N+VRL+G C Sbjct: 315 NKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVC 374 Query: 405 SEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQR 584 + +I E+M N +L +Y+ + LL P ++ +A IA GM YL + Sbjct: 375 THEAPFYIITEFMCNGNLLEYL----RRTDKSLLPPIILVQMASQIASGMSYLEA---RH 427 Query: 585 ILHFDIKPHNILL 623 +H D+ N L+ Sbjct: 428 FIHRDLAARNCLV 440
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+++ + + + F NEVA + H NI+ MG+ + Sbjct: 354 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMT 413 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL K++ HV ++ +++DIA A+GM+YLH + I Sbjct: 414 K-DNLAIVTQWCEGSSLYKHL--HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNI 464 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 465 IHRDMKSNNIFL 476
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+++ + + + F NEVA + H NI+ MG+ + Sbjct: 354 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMT 413 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL K++ HV ++ +++DIA A+GM+YLH + I Sbjct: 414 K-DNLAIVTQWCEGSSLYKHL--HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNI 464 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 465 IHRDMKSNNIFL 476
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/143 (30%), Positives = 75/143 (52%) Frame = +3 Query: 195 PEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHH 374 P + + RR KLG+G FG V++G +PVAVK+++S+ + + E+ + + H Sbjct: 230 PRSEFVLRR---KLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRH 286 Query: 375 ANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGM 554 ++RL CS G ++ E M +L+ Y+ S K L+ +L A +A GM Sbjct: 287 ERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSS----EGKALSLPHLLGFACQVAEGM 342 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 YL + +R++H D+ N+L+ Sbjct: 343 SYLEE---RRVVHRDLAARNVLV 362
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 69.7 bits (169), Expect = 7e-12 Identities = 48/134 (35%), Positives = 71/134 (52%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLMGF 401 ++G G FG+VY+ PVAVK L T + + F NEVA + H NI+ MG Sbjct: 434 RIGSGSFGTVYRAHWHG--PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG- 490 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C A++ ++ SL K++ HVS KL ++DI +A+GM+YLH + Sbjct: 491 CVSKPSLAIVTQWCEGSSLYKHV--HVSETKFKL---NTLIDIGRQVAQGMDYLHA---K 542 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 543 NIIHRDLKSNNIFL 556
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+++ + + + F NEVA + H NI+ MG+ + Sbjct: 29 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMT 88 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL K++ HV ++ +++DIA A+GM+YLH + I Sbjct: 89 K-DNLAIVTQWCEGSSLYKHL--HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNI 139 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 140 IHRDMKSNNIFL 151
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 69.3 bits (168), Expect = 9e-12 Identities = 50/158 (31%), Positives = 80/158 (50%), Gaps = 7/158 (4%) Frame = +3 Query: 171 SKPTRYTFP------EVKKIARRFKDKLGQGGFGSVYKGELRN-GVPVAVKMLESSTGEG 329 +KPT Y E+++ K KLG G +G VY G + + VAVK L+ T E Sbjct: 267 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 326 Query: 330 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 509 EEF+ E A + I H N+V+L+G C+ ++ EYMP +L Y+ +++ + Sbjct: 327 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL----RECNREEVT 382 Query: 510 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +L +A I+ MEYL + + +H D+ N L+ Sbjct: 383 AVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCLV 417
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 68.9 bits (167), Expect = 1e-11 Identities = 56/166 (33%), Positives = 76/166 (45%), Gaps = 8/166 (4%) Frame = +3 Query: 150 FLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGEL-----RNGVPVAVKMLES 314 F A+ PT++ +K F +LG+G FGSV G VAVK L+ Sbjct: 832 FSGAFEDRDPTQFEERHLK-----FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH 886 Query: 315 STGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRR--ALIYEYMPNESLEKYIFSHVS 485 ST E +F E+ + + H NIV+ G C RR LI EY+P SL Y+ H Sbjct: 887 STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE 946 Query: 486 NISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 I K+L I +GMEYL +R +H D+ NIL+ Sbjct: 947 RIDH-----IKLLQYTSQICKGMEYLG---TKRYIHRDLATRNILV 984 Score = 43.5 bits (101), Expect = 5e-04 Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 11/145 (7%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELR--------NGVPVAVKMLESS-TGEGEEFINEVATIGLIHH 374 F + LGQG F ++KG R + V +K+L+ + E F + + + H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSH 606 Query: 375 ANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVS--NISQKLLAPTKMLDIALGIAR 548 ++V G C G L+ E++ SL+ Y+ + + NI K L++A +A Sbjct: 607 KHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK-------LEVAKQLAW 659 Query: 549 GMEYLHQGCNQRILHFDIKPHNILL 623 M +L + ++H ++ NILL Sbjct: 660 AMHFLEE---NTLIHGNVCAKNILL 681
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 68.6 bits (166), Expect = 1e-11 Identities = 40/134 (29%), Positives = 65/134 (48%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F ++G G FG V+ GE R +PVA+K + + E+FI E + + H+ +V+L G Sbjct: 273 FVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGV 332 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C + ++ E+M N L Y+ + + LL L + I GM YL + C Sbjct: 333 CIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALL-----LSMCQDICEGMAYLERSC-- 385 Query: 582 RILHFDIKPHNILL 623 +H D+ N L+ Sbjct: 386 -YIHRDLAARNCLV 398
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 68.6 bits (166), Expect = 1e-11 Identities = 42/131 (32%), Positives = 66/131 (50%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSE 410 KLG+G FG V+ G+ RN + VAVK L T F+ E A + H +V L CS+ Sbjct: 289 KLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ 348 Query: 411 GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 590 ++ EYM SL ++ + L ++ IA +A GMEYL +++++ Sbjct: 349 EEPIYIVQEYMSKGSLLDFL----REGDGRYLHFEDLIYIATQVASGMEYLE---SKQLI 401 Query: 591 HFDIKPHNILL 623 H D+ N+L+ Sbjct: 402 HRDLAARNVLI 412
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 68.6 bits (166), Expect = 1e-11 Identities = 40/134 (29%), Positives = 65/134 (48%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F ++G G FG V+ G N VA+K ++ E+FI E + + H +V+L G Sbjct: 370 FVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGV 429 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C E L++E+M + L Y+ S + L A +L + L + GM YL + C Sbjct: 430 CLEQAPICLVFEFMEHGCLSDYLRS-----QRGLFAAETLLGMCLDVCEGMAYLEKAC-- 482 Query: 582 RILHFDIKPHNILL 623 ++H D+ N L+ Sbjct: 483 -VIHRDLAARNCLV 495
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%) Frame = +3 Query: 162 YGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRN-GVPVAVKMLESSTGEGEEF 338 YG S Y E+++ K KLG G +G VY+G + + VAVK L+ T E EEF Sbjct: 112 YGVSP--NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 169 Query: 339 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 518 + E A + I H N+V+L+G C+ +I E+M +L Y+ +++ ++ Sbjct: 170 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL----RECNRQEVSAVV 225 Query: 519 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +L +A I+ MEYL + + +H D+ N L+ Sbjct: 226 LLYMATQISSAMEYLEK---KNFIHRDLAARNCLV 257
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 68.2 bits (165), Expect = 2e-11 Identities = 46/142 (32%), Positives = 73/142 (51%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R KLG G FG V+ G N VAVK L+ T F++E + + H Sbjct: 234 EIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSPASFLDEAGVMKKLRHK 293 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 ++V+L CS+ ++ EYM SL Y+ S ++ +L PT ++D+A +A GM Sbjct: 294 HLVQLYAICSDREPIYIVTEYMSGGSLLDYL-SKGEGVNLQL--PT-LIDMAAQVASGMA 349 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 +L Q +H D+ NIL+ Sbjct: 350 FLEA---QGYIHRDLAARNILV 368
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNG-----VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRL 392 +G G FG VYKG L+ +PVA+K L++ E + +F++E + +G H NI+ L Sbjct: 620 IGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIPL 679 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 G S+ +I EYM N +L+K++ S +++ + GIA GM+YL Sbjct: 680 EGVVSKYKPMMIITEYMENGALDKFLREKDGEFS-----VLQLVGMLRGIASGMKYL--- 731 Query: 573 CNQRILHFDIKPHNILL 623 N +H D+ NIL+ Sbjct: 732 ANMNYVHRDLAARNILV 748
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%) Frame = +3 Query: 162 YGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRN-GVPVAVKMLESSTGEGEEF 338 YG S Y E+++ K KLG G +G VY+G + + VAVK L+ T E EEF Sbjct: 226 YGVSP--NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 283 Query: 339 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 518 + E A + I H N+V+L+G C+ +I E+M +L Y+ +++ ++ Sbjct: 284 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL----RECNRQEVSAVV 339 Query: 519 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +L +A I+ MEYL + + +H D+ N L+ Sbjct: 340 LLYMATQISSAMEYLEK---KNFIHRDLAARNCLV 371
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 67.8 bits (164), Expect = 3e-11 Identities = 54/180 (30%), Positives = 85/180 (47%), Gaps = 20/180 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VA 296 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VA Sbjct: 515 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVA 570 Query: 297 VKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 VK L+ T ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 571 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 630 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +H + ++ L ++ML IA IA GM YL +Q +H D+ N L+ Sbjct: 631 AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLV 687
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 67.8 bits (164), Expect = 3e-11 Identities = 42/131 (32%), Positives = 64/131 (48%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSE 410 KLG G FG VY+G N PVAVK L++ T + F+ E + + H +++L C++ Sbjct: 100 KLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAAFLAEAQIMKKLRHPKLIQLYAVCTQ 159 Query: 411 GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 590 G +I E M SL Y+ L +++D+A +A GM YL + Sbjct: 160 GEPVYIITELMSKGSLLDYLQGEAG-----ALKLPQLIDMAAQVAAGMAYLEL---HNYI 211 Query: 591 HFDIKPHNILL 623 H D+ NIL+ Sbjct: 212 HRDLAARNILV 222
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 67.8 bits (164), Expect = 3e-11 Identities = 54/180 (30%), Positives = 85/180 (47%), Gaps = 20/180 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VA 296 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VA Sbjct: 515 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVA 570 Query: 297 VKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 VK L+ T ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 571 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 630 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +H + ++ L ++ML IA IA GM YL +Q +H D+ N L+ Sbjct: 631 AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 67.8 bits (164), Expect = 3e-11 Identities = 51/180 (28%), Positives = 83/180 (46%), Gaps = 20/180 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVPVAVKML-- 308 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VKML Sbjct: 515 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKVKMLVA 570 Query: 309 -----ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 + + ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 571 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 630 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +H + ++ L ++ML IA I GM YL +Q +H D+ N L+ Sbjct: 631 AHGPDAMILVDGQPRQAKGELGLSQMLHIASQICSGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 67.8 bits (164), Expect = 3e-11 Identities = 54/180 (30%), Positives = 85/180 (47%), Gaps = 20/180 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VA 296 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VA Sbjct: 515 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVA 570 Query: 297 VKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 VK L+ T ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 571 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 630 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +H + ++ L ++ML IA IA GM YL +Q +H D+ N L+ Sbjct: 631 AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 67.8 bits (164), Expect = 3e-11 Identities = 54/180 (30%), Positives = 85/180 (47%), Gaps = 20/180 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VA 296 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VA Sbjct: 515 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVA 570 Query: 297 VKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 VK L+ T ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 571 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 630 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +H + ++ L ++ML IA IA GM YL +Q +H D+ N L+ Sbjct: 631 AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 67.8 bits (164), Expect = 3e-11 Identities = 54/180 (30%), Positives = 85/180 (47%), Gaps = 20/180 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VA 296 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VA Sbjct: 517 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTNDKMLVA 572 Query: 297 VKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 VK L+ T ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 573 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 632 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +H + ++ L ++ML IA IA GM YL +Q +H D+ N L+ Sbjct: 633 AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLV 689
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 67.4 bits (163), Expect = 3e-11 Identities = 51/155 (32%), Positives = 79/155 (50%), Gaps = 4/155 (2%) Frame = +3 Query: 171 SKPTRYTFPEVKKIARRFK-DKLGQGGFGSVYKGELR-NGVPVAVKMLESSTGEGEEF-- 338 S P+ T P+ K K +KLG+G + +VYKG+ + NG VA+K++ EG F Sbjct: 119 SSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTA 178 Query: 339 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 518 I E + + + HANIV L L++EY+ + L +Y+ H L P Sbjct: 179 IREASLLKGLKHANIVLLHDIIHTKETLTLVFEYV-HTDLCQYMEQHPGG-----LHPDN 232 Query: 519 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + + RG+ Y+HQ + ILH D+KP N+L+ Sbjct: 233 VKLFLFQLLRGLSYIHQ---RYILHRDLKPQNLLI 264
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 67.4 bits (163), Expect = 3e-11 Identities = 51/155 (32%), Positives = 79/155 (50%), Gaps = 4/155 (2%) Frame = +3 Query: 171 SKPTRYTFPEVKKIARRFK-DKLGQGGFGSVYKGELR-NGVPVAVKMLESSTGEGEEF-- 338 S P+ T P+ K K +KLG+G + +VYKG+ + NG VA+K++ EG F Sbjct: 119 SSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTA 178 Query: 339 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 518 I E + + + HANIV L L++EY+ + L +Y+ H L P Sbjct: 179 IREASLLKGLKHANIVLLHDIIHTKETLTLVFEYV-HTDLCQYMDKHPGG-----LHPDN 232 Query: 519 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + + RG+ Y+HQ + ILH D+KP N+L+ Sbjct: 233 VKLFLFQLLRGLSYIHQ---RYILHRDLKPQNLLI 264
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 67.4 bits (163), Expect = 3e-11 Identities = 39/134 (29%), Positives = 63/134 (47%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F ++G G FG V+ G N VA+K + E+FI E + + H +V+L G Sbjct: 365 FVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGV 424 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C E L++E+M + L Y+ + L A +L + L + GM YL + C Sbjct: 425 CLEQAPICLVFEFMEHGCLSDYL-----RTQRGLFAAETLLGMCLDVCEGMAYLEEAC-- 477 Query: 582 RILHFDIKPHNILL 623 ++H D+ N L+ Sbjct: 478 -VIHRDLAARNCLV 490
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 67.4 bits (163), Expect = 3e-11 Identities = 51/176 (28%), Positives = 84/176 (47%), Gaps = 19/176 (10%) Frame = +3 Query: 153 LKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VAVKM 305 L+ + P ++ V I RR K +LG+G FG V+ E N +P VAVK Sbjct: 486 LQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKA 545 Query: 306 L-ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH- 479 L E+S ++F E + ++ H +IVR G C+EG +++EYM + L +++ SH Sbjct: 546 LKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHG 605 Query: 480 --------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +++ L ++L +A +A GM YL +H D+ N L+ Sbjct: 606 PDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---AGLHFVHRDLATRNCLV 658
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 67.4 bits (163), Expect = 3e-11 Identities = 41/142 (28%), Positives = 71/142 (50%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+K+ +LG G FG V G+ + VAVKM++ + +EF E T+ + H Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHP 470 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+ G CS+ ++ EY+ N L Y+ SH K L P+++L++ + GM Sbjct: 471 KLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-----GKGLEPSQLLEMCYDVCEGMA 525 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 +L + + +H D+ N L+ Sbjct: 526 FLE---SHQFIHRDLAARNCLV 544
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 67.0 bits (162), Expect = 4e-11 Identities = 45/135 (33%), Positives = 70/135 (51%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR-NGVPVAVKMLESSTGEGEEF--INEVATIGLIHHANIVRLMG 398 +KLG+G + +VYKG R NG VA+K++ + EG F I E + + + HANIV L Sbjct: 56 EKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHD 115 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 ++EYM + L +Y+ H L P + + RG+ Y+H + Sbjct: 116 IIHTKETLTFVFEYMHTD-LAQYMSQHPGG-----LHPHNVRLFMFQLLRGLAYIH---H 166 Query: 579 QRILHFDIKPHNILL 623 Q +LH D+KP N+L+ Sbjct: 167 QHVLHRDLKPQNLLI 181
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 67.0 bits (162), Expect = 4e-11 Identities = 43/132 (32%), Positives = 74/132 (56%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+VYKG+ V V + K+ + + + + F NEVA + H NI+ MG+ + Sbjct: 345 RIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMT 404 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + A++ ++ SL Y HV + ++ +++DIA A+GM+YLH + I Sbjct: 405 K-DNLAIVTQWCEGSSL--YYHLHVLDTKFQMF---QLIDIARQTAQGMDYLHA---KNI 455 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 456 IHRDMKSNNIFL 467
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 67.0 bits (162), Expect = 4e-11 Identities = 49/155 (31%), Positives = 79/155 (50%), Gaps = 1/155 (0%) Frame = +3 Query: 162 YGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRN-GVPVAVKMLESSTGEGEEF 338 YG S Y E+++ K KLG G +G VY+G + + VAVK L+ T E EEF Sbjct: 175 YGVSP--NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 232 Query: 339 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 518 + E A + I H N+V+L+G C+ +I E+M +L Y+ +++ + Sbjct: 233 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL----RECNRQEVNAVV 288 Query: 519 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +L +A I+ MEYL + + +H D+ N L+ Sbjct: 289 LLYMATQISSAMEYLEK---KNFIHRDLAARNCLV 320
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 67.0 bits (162), Expect = 4e-11 Identities = 49/155 (31%), Positives = 79/155 (50%), Gaps = 1/155 (0%) Frame = +3 Query: 162 YGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRN-GVPVAVKMLESSTGEGEEF 338 YG S Y E+++ K KLG G +G VY+G + + VAVK L+ T E EEF Sbjct: 226 YGVSP--NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 283 Query: 339 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 518 + E A + I H N+V+L+G C+ +I E+M +L Y+ +++ + Sbjct: 284 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL----RECNRQEVNAVV 339 Query: 519 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +L +A I+ MEYL + + +H D+ N L+ Sbjct: 340 LLYMATQISSAMEYLEK---KNFIHRDLAARNCLV 371
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 67.0 bits (162), Expect = 4e-11 Identities = 38/131 (29%), Positives = 69/131 (52%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSE 410 KLG+G FG V++G +PVA+K+++S+ + + E+ T+ + H ++RL CS Sbjct: 235 KLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSG 294 Query: 411 GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 590 G ++ E M +L+ ++ + L +L A +A GM YL + QR++ Sbjct: 295 GEPVYIVTELMRKGNLQAFL----GTPEGRALRLPPLLGFACQVAEGMSYLEE---QRVV 347 Query: 591 HFDIKPHNILL 623 H D+ N+L+ Sbjct: 348 HRDLAARNVLV 358
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 67.0 bits (162), Expect = 4e-11 Identities = 42/142 (29%), Positives = 71/142 (50%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E++K + +LG G FG V++G VAVK L+ T EEF+ E + + + H Sbjct: 234 EIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVEEFLQEASIMKRLRHP 293 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +++L C++ ++ E M SL +Y+ +L +++D+A +A GM Sbjct: 294 KLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRG-----EDGVLKIEQLVDVAAQVASGMS 348 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL Q Q +H D+ NIL+ Sbjct: 349 YLEQ---QNYIHRDLAARNILV 367
>LET23_CAEEL (P24348) Receptor tyrosine-protein kinase let-23 precursor (EC| 2.7.10.1) (Lethal protein 23) Length = 1367 Score = 67.0 bits (162), Expect = 4e-11 Identities = 37/145 (25%), Positives = 75/145 (51%), Gaps = 6/145 (4%) Frame = +3 Query: 207 KIARRFKDKLGQGGFGSVYKG-----ELRN-GVPVAVKMLESSTGEGEEFINEVATIGLI 368 ++ + KLG G FG+V+ G +N +PVA+K+ ++ + +E + E + + Sbjct: 926 ELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRL 985 Query: 369 HHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIAR 548 H N+++++GFC ++ Y P +L+ ++ H N+ + + + IA Sbjct: 986 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAR-----EQVLYCYQIAS 1040 Query: 549 GMEYLHQGCNQRILHFDIKPHNILL 623 GM+YL + QR++H D+ N+L+ Sbjct: 1041 GMQYLEK---QRVVHRDLATRNVLV 1062
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 67.0 bits (162), Expect = 4e-11 Identities = 48/154 (31%), Positives = 83/154 (53%), Gaps = 14/154 (9%) Frame = +3 Query: 204 KKIARRFKDK-------LGQGGFGSVYKGE-LRNG----VPVAVKMLESSTGEG--EEFI 341 K +AR FK+ LG G FG+V+KG + G +PV +K++E +G + Sbjct: 696 KVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVT 755 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 + + +G + HA+IVRL+G C G+ L+ +Y+P SL ++ H ++ L P + Sbjct: 756 DHMLAVGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVKQH-----RETLGPQLL 809 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L+ + IA+GM YL + ++H D+ N++L Sbjct: 810 LNWGVQIAKGMYYLEE---HSMVHRDLALRNVML 840
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 67.0 bits (162), Expect = 4e-11 Identities = 48/154 (31%), Positives = 83/154 (53%), Gaps = 14/154 (9%) Frame = +3 Query: 204 KKIARRFKDK-------LGQGGFGSVYKGE-LRNG----VPVAVKMLESSTGEG--EEFI 341 K +AR FK+ LG G FG+V+KG + G +PV +K++E +G + Sbjct: 696 KVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVT 755 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 + + +G + HA+IVRL+G C G+ L+ +Y+P SL ++ H ++ L P + Sbjct: 756 DHMLAVGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQH-----RETLGPQLL 809 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L+ + IA+GM YL + ++H D+ N++L Sbjct: 810 LNWGVQIAKGMYYLEE---HSMVHRDLALRNVML 840
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 66.6 bits (161), Expect = 6e-11 Identities = 45/140 (32%), Positives = 66/140 (47%), Gaps = 5/140 (3%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGE-----GEEFINEVATIGLIHHANI 383 R ++ +G GGFG VY+G R G VAVK E E E ++ H NI Sbjct: 118 RLEEVIGIGGFGKVYRGSWR-GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNI 176 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 + L C E L+ EY L + + + + + P +++ A+ IARGM YL Sbjct: 177 IALKAVCLEEPNLCLVMEYAAGGPLSRAL-------AGRRVPPHVLVNWAVQIARGMHYL 229 Query: 564 HQGCNQRILHFDIKPHNILL 623 H ++H D+K +NILL Sbjct: 230 HCEALVPVIHRDLKSNNILL 249
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 66.2 bits (160), Expect = 7e-11 Identities = 53/177 (29%), Positives = 83/177 (46%), Gaps = 20/177 (11%) Frame = +3 Query: 144 EMFLKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VA 296 + F + + KP Y V+ I RR K +LG+G FG V+ E N P VA Sbjct: 515 QYFRQGHNCHKPDTY----VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVA 570 Query: 297 VKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 VK L+ T ++F E + + H +IV+ G C +G +++EYM + L K++ Sbjct: 571 VKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR 630 Query: 474 SHVSNI----------SQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHN 614 +H + ++ L ++ML IA IA GM YL +Q +H D+ N Sbjct: 631 AHGPDAMILVDGQPXQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRN 684
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 66.2 bits (160), Expect = 7e-11 Identities = 51/148 (34%), Positives = 75/148 (50%), Gaps = 7/148 (4%) Frame = +3 Query: 201 VKKIARRFKDKLGQGGFGSVYKG----ELRN-GVPVAVKMLESSTG--EGEEFINEVATI 359 VK R LG G FG VYKG E N +PVA+K L STG EEF+ E + Sbjct: 933 VKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIM 992 Query: 360 GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALG 539 H N+++L+ C ++ LI + MP L Y+ ++ I K L L+ + Sbjct: 993 ASEEHVNLLKLLAVCM-SSQMMLITQLMPLGCLLDYVRNNRDKIGSKAL-----LNWSTQ 1046 Query: 540 IARGMEYLHQGCNQRILHFDIKPHNILL 623 IA+GM YL + +R++H D+ N+L+ Sbjct: 1047 IAKGMSYLEE---KRLVHRDLAARNVLV 1071
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/147 (31%), Positives = 71/147 (48%), Gaps = 14/147 (9%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVP------VAVKML-ESSTGEGEEFINEVATIGLIHHANI 383 K +LG+G FG V+ E N P VAVK L ++S ++F E + + H +I Sbjct: 541 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI 600 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSH-------VSNISQKLLAPTKMLDIALGI 542 V+ G C EG +++EYM + L K++ +H L ++ML IA I Sbjct: 601 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 660 Query: 543 ARGMEYLHQGCNQRILHFDIKPHNILL 623 A GM YL +Q +H D+ N L+ Sbjct: 661 AAGMVYL---ASQHFVHRDLATRNCLV 684
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 65.9 bits (159), Expect = 1e-10 Identities = 41/135 (30%), Positives = 75/135 (55%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR-NGVPVAVKMLESSTGEG--EEFINEVATIGLIHHANIVRLMG 398 +KLG+G + VYKG+ R G VA+K++ EG I E++ + + H NI+ L Sbjct: 7 EKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEGTPSTAIREISLMKELRHPNIMSLSD 66 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + L++EYM + L+KY+ ++ +Q L P+++ + + +G+ + H+ Sbjct: 67 VLQTENKLMLVFEYM-EKDLKKYMDTYG---NQGALPPSQVKNFTQQLLKGISFCHE--- 119 Query: 579 QRILHFDIKPHNILL 623 R+LH D+KP N+L+ Sbjct: 120 NRVLHRDLKPQNLLI 134
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/148 (31%), Positives = 80/148 (54%), Gaps = 8/148 (5%) Frame = +3 Query: 204 KKIARRFKDKLGQGGFGSV----YKGELRNGVPVAVKMLESSTGEGE--EFINEVATIGL 365 K+ +R +D LG+G FG V Y E G VAVK L+ +G + E+ + Sbjct: 861 KRFLKRIRD-LGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEIEILRN 919 Query: 366 IHHANIVRLMGFCSE--GTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALG 539 ++H NIV+ G C+E G LI E++P+ SL++Y+ + + I+ K + L A+ Sbjct: 920 LYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLK-----QQLKYAVQ 974 Query: 540 IARGMEYLHQGCNQRILHFDIKPHNILL 623 I +GM+YL +++ +H D+ N+L+ Sbjct: 975 ICKGMDYLG---SRQYVHRDLAARNVLV 999
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/147 (31%), Positives = 71/147 (48%), Gaps = 14/147 (9%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVP------VAVKML-ESSTGEGEEFINEVATIGLIHHANI 383 K +LG+G FG V+ E N P VAVK L ++S ++F E + + H +I Sbjct: 537 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI 596 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSH-------VSNISQKLLAPTKMLDIALGI 542 V+ G C EG +++EYM + L K++ +H L ++ML IA I Sbjct: 597 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQI 656 Query: 543 ARGMEYLHQGCNQRILHFDIKPHNILL 623 A GM YL +Q +H D+ N L+ Sbjct: 657 AAGMVYL---ASQHFVHRDLATRNCLV 680
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 65.9 bits (159), Expect = 1e-10 Identities = 40/134 (29%), Positives = 68/134 (50%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F +LG G FG V G+ R VA+KM+ + +EFI+E + + H +V+L G Sbjct: 402 FLKELGTGQFGVVKYGKWRGQYNVAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLYGV 461 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C++ +I EYM N L ++ +Q+ P ++L++ + MEYL ++ Sbjct: 462 CTKQRPIFIITEYMANGCLLNFL-----RETQRRFQPAELLEMCKDVCEAMEYLE---SK 513 Query: 582 RILHFDIKPHNILL 623 + LH D+ N L+ Sbjct: 514 QFLHRDLAARNCLV 527
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/154 (31%), Positives = 82/154 (53%), Gaps = 14/154 (9%) Frame = +3 Query: 204 KKIARRFKDK-------LGQGGFGSVYKGE-LRNG----VPVAVKMLESSTGEG--EEFI 341 K +AR FK+ LG G FG+V+KG + G +PV +K++E +G + Sbjct: 698 KVLARIFKETELKKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVT 757 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 + + IG + HA+IVRL+G C G+ L+ +Y+P SL ++ H + L P + Sbjct: 758 DHMLAIGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQH-----RGALGPQLL 811 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L+ + IA+GM YL + ++H ++ N+LL Sbjct: 812 LNWGVQIAKGMYYLEE---HGMVHRNLAARNVLL 842
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/154 (31%), Positives = 82/154 (53%), Gaps = 14/154 (9%) Frame = +3 Query: 204 KKIARRFKDK-------LGQGGFGSVYKGE-LRNG----VPVAVKMLESSTGEG--EEFI 341 K +AR FK+ LG G FG+V+KG + G +PV +K++E +G + Sbjct: 698 KVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVT 757 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKM 521 + + IG + HA+IVRL+G C G+ L+ +Y+P SL ++ H + L P + Sbjct: 758 DHMLAIGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQH-----RGALGPQLL 811 Query: 522 LDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L+ + IA+GM YL + ++H ++ N+LL Sbjct: 812 LNWGVQIAKGMYYLEE---HGMVHRNLAARNVLL 842
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/147 (31%), Positives = 71/147 (48%), Gaps = 14/147 (9%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVP------VAVKML-ESSTGEGEEFINEVATIGLIHHANI 383 K +LG+G FG V+ E N P VAVK L ++S ++F E + + H +I Sbjct: 540 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI 599 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSH-------VSNISQKLLAPTKMLDIALGI 542 V+ G C EG +++EYM + L K++ +H L ++ML IA I Sbjct: 600 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 659 Query: 543 ARGMEYLHQGCNQRILHFDIKPHNILL 623 A GM YL +Q +H D+ N L+ Sbjct: 660 AAGMVYL---ASQHFVHRDLATRNCLV 683
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/147 (31%), Positives = 71/147 (48%), Gaps = 14/147 (9%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVP------VAVKML-ESSTGEGEEFINEVATIGLIHHANI 383 K +LG+G FG V+ E N P VAVK L ++S ++F E + + H +I Sbjct: 540 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI 599 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSH-------VSNISQKLLAPTKMLDIALGI 542 V+ G C EG +++EYM + L K++ +H L ++ML IA I Sbjct: 600 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 659 Query: 543 ARGMEYLHQGCNQRILHFDIKPHNILL 623 A GM YL +Q +H D+ N L+ Sbjct: 660 AAGMVYL---ASQHFVHRDLATRNCLV 683
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 65.5 bits (158), Expect = 1e-10 Identities = 48/172 (27%), Positives = 83/172 (48%), Gaps = 16/172 (9%) Frame = +3 Query: 156 KAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNG---VPVAVKMLE--SST 320 KA PT Y + I +F+D +G+G FG V K ++ + A+K ++ +S Sbjct: 804 KAKNNPDPTIYPVLDWNDI--KFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK 861 Query: 321 GEGEEFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH------ 479 + +F E+ + L HH NI+ L+G C L EY P+ +L ++ Sbjct: 862 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETD 921 Query: 480 ----VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 ++N + L+ ++L A +ARGM+YL Q ++ +H D+ NIL+ Sbjct: 922 PAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARNILV 970
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGF 401 ++G G FG+VYKG+ VAVKML + ++ F NEV + H NI+ MG+ Sbjct: 502 RIGSGSFGTVYKGKWHG--DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY 559 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 S + A++ ++ SL + H+ I K K++DIA A+GM+YLH + Sbjct: 560 -STKPQLAIVTQWCEGSSL----YHHLHIIETK-FEMIKLIDIARQTAQGMDYLHA---K 610 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 611 SIIHRDLKSNNIFL 624
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGF 401 ++G G FG+VYKG+ VAVKML + ++ F NEV + H NI+ MG+ Sbjct: 88 RIGSGSFGTVYKGKWHG--DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY 145 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 S + A++ ++ SL + H+ I K K++DIA A+GM+YLH + Sbjct: 146 -STKPQLAIVTQWCEGSSL----YHHLHIIETK-FEMIKLIDIARQTAQGMDYLHA---K 196 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 197 SIIHRDLKSNNIFL 210
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 65.5 bits (158), Expect = 1e-10 Identities = 50/144 (34%), Positives = 76/144 (52%), Gaps = 13/144 (9%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMG 398 +LG GGFGSVYK +GVPVA+K + T F E+ I +HH NI+R++ Sbjct: 66 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTRTLRASQRNFWAEL-NIARLHHDNIIRVVA 123 Query: 399 FCS---EGTRR--ALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARG 551 + EG+ +I E+ N +L + I+ + ++ L+ K L +L I G Sbjct: 124 ASTRTPEGSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDIVNG 183 Query: 552 MEYLHQGCNQRILHFDIKPHNILL 623 + +LH +Q ILH D+KP NIL+ Sbjct: 184 LLFLH---SQSILHLDLKPANILI 204
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 65.5 bits (158), Expect = 1e-10 Identities = 38/134 (28%), Positives = 67/134 (50%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F ++G G FG V+ GE R+ + VA+K + + E+FI E + + H+ +V+L G Sbjct: 273 FIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGV 332 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C + ++ E+M N L Y+ + + +++L L + I GMEYL + Sbjct: 333 CIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEML-----LSVCQDICEGMEYLER---N 384 Query: 582 RILHFDIKPHNILL 623 +H D+ N L+ Sbjct: 385 GYIHRDLAARNCLV 398
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGF 401 ++G G FG+VYKG+ VAVKML + ++ F NEV + H NI+ MG+ Sbjct: 72 RIGSGSFGTVYKGKWHG--DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY 129 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 S + A++ ++ SL + H+ I K K++DIA A+GM+YLH + Sbjct: 130 -STKPQLAIVTQWCEGSSL----YHHLHIIETK-FEMIKLIDIARQTAQGMDYLHA---K 180 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 181 SIIHRDLKSNNIFL 194
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 65.5 bits (158), Expect = 1e-10 Identities = 48/172 (27%), Positives = 83/172 (48%), Gaps = 16/172 (9%) Frame = +3 Query: 156 KAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNG---VPVAVKMLE--SST 320 KA PT Y + I +F+D +G+G FG V K ++ + A+K ++ +S Sbjct: 807 KAKNNPDPTIYPVLDWNDI--KFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK 864 Query: 321 GEGEEFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH------ 479 + +F E+ + L HH NI+ L+G C L EY P+ +L ++ Sbjct: 865 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETD 924 Query: 480 ----VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 ++N + L+ ++L A +ARGM+YL Q ++ +H D+ NIL+ Sbjct: 925 PAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARNILV 973
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGF 401 ++G G FG+VYKG+ VAVKML + ++ F NEV + H NI+ MG+ Sbjct: 462 RIGSGSFGTVYKGKWHG--DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY 519 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 S + A++ ++ SL + H+ I K K++DIA A+GM+YLH + Sbjct: 520 -STKPQLAIVTQWCEGSSL----YHHLHIIETK-FEMIKLIDIARQTAQGMDYLHA---K 570 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 571 SIIHRDLKSNNIFL 584
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 65.5 bits (158), Expect = 1e-10 Identities = 45/139 (32%), Positives = 72/139 (51%), Gaps = 7/139 (5%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE-------EFINEVATIGLIHHANIV 386 +K G +Y+G + VAVKM+ T + E +F +EVA + + H NIV Sbjct: 90 NKFASGAHSRIYRGIYKQRA-VAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIV 148 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLH 566 + + C + +I EYM +L Y+ + L+ +L +AL I+RGMEYLH Sbjct: 149 QFIAACKKPPVYCIITEYMSQGNLRMYL----NKKEPYSLSIETVLRLALDISRGMEYLH 204 Query: 567 QGCNQRILHFDIKPHNILL 623 +Q ++H D+K +N+LL Sbjct: 205 ---SQGVIHRDLKSNNLLL 220
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGF 401 ++G G FG+VYKG+ VAVKML + ++ F NEV + H NI+ MG+ Sbjct: 24 RIGSGSFGTVYKGKWHG--DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY 81 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 S + A++ ++ SL + H+ I K K++DIA A+GM+YLH + Sbjct: 82 -STKPQLAIVTQWCEGSSL----YHHLHIIETK-FEMIKLIDIARQTAQGMDYLHA---K 132 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 133 SIIHRDLKSNNIFL 146
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 65.5 bits (158), Expect = 1e-10 Identities = 46/170 (27%), Positives = 83/170 (48%) Frame = +3 Query: 114 KYNEEINKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPV 293 K ++ + +++E + KP E+ + + + KLG G FG V+ G N V Sbjct: 212 KQSDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKV 271 Query: 294 AVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 AVK L+ T + F+ E + + H +VRL ++ +I E+M SL ++ Sbjct: 272 AVKTLKPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFL- 330 Query: 474 SHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 S+ K+L P K++D + IA GM Y+ + + +H D++ N+L+ Sbjct: 331 --KSDEGSKVLLP-KLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLV 374
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 65.5 bits (158), Expect = 1e-10 Identities = 39/142 (27%), Positives = 74/142 (52%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + + +LG G FG V++G N PVAVK L+ + + +F+ E + + H Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHP 287 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +++L C+ +I E M + SL++Y+ N + + T+ +D+A +A GM Sbjct: 288 KLIQLYAVCTLEDPIYIITELMRHGSLQEYL----QNDTGSKIHLTQQVDMAAQVASGMA 343 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL ++ +H D+ N+L+ Sbjct: 344 YLE---SRNYIHRDLAARNVLV 362
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGF 401 ++G G FG+VYKG+ VAVKML + ++ F NEV + H NI+ MG+ Sbjct: 502 RIGSGSFGTVYKGKWHG--DVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY 559 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 S + A++ ++ SL + H+ I K K++DIA A+GM+YLH + Sbjct: 560 -STKPQLAIVTQWCEGSSL----YHHLHIIETK-FEMIKLIDIARQTAQGMDYLHA---K 610 Query: 582 RILHFDIKPHNILL 623 I+H D+K +NI L Sbjct: 611 SIIHRDLKSNNIFL 624
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 65.5 bits (158), Expect = 1e-10 Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKG-----ELRNGVPVAVKMLESSTG--EGEEFINEVATIGLIHHANIVRL 392 LG G FG+VYKG + +PVA+K L +T +E ++E + + + ++ RL Sbjct: 138 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 197 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + LI + MP L YI H NI + L L+ + IA+GM YL + Sbjct: 198 LGICLTSTVQ-LITQLMPYGCLLDYIREHKDNIGSQYL-----LNWCVQIAKGMNYLEE- 250 Query: 573 CNQRILHFDIKPHNILL 623 +R++H D+ N+L+ Sbjct: 251 --RRLVHRDLAARNVLV 265
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 65.1 bits (157), Expect = 2e-10 Identities = 44/135 (32%), Positives = 72/135 (53%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +KLG G + +VYKG ++ GV VA+K L+S G I E++ + + H NIVRL Sbjct: 10 EKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLYD 69 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + L++EYM N+ L+KY+ S + + L + + G+ + H+ Sbjct: 70 VIHTENKLTLVFEYMDND-LKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHE--- 125 Query: 579 QRILHFDIKPHNILL 623 +ILH D+KP N+L+ Sbjct: 126 NKILHRDLKPQNLLI 140
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 65.1 bits (157), Expect = 2e-10 Identities = 44/137 (32%), Positives = 72/137 (52%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKG-----ELRNGVPVAVKMLESSTG--EGEEFINEVATIGLIHHANIVRL 392 LG G FG++YKG + +PVA+K L +T +E ++E + + + ++ RL Sbjct: 138 LGSGAFGTIYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 197 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + LI + MP L YI H NI + L L+ + IA+GM YL + Sbjct: 198 LGICLTSTVQ-LITQLMPYGCLLDYIREHKDNIGSQYL-----LNWCVQIAKGMNYLEE- 250 Query: 573 CNQRILHFDIKPHNILL 623 +R++H D+ N+L+ Sbjct: 251 --RRLVHRDLAARNVLV 265
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 64.7 bits (156), Expect = 2e-10 Identities = 55/177 (31%), Positives = 89/177 (50%), Gaps = 11/177 (6%) Frame = +3 Query: 126 EINKKVEMFLKAYGTSKPTRYTFPE--VKKIARRFKDKLGQGGFGSV----YKGELRN-G 284 +INK E +PT P K+ +R +D LG+G FG V Y E N G Sbjct: 843 DINKLEEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRD-LGEGHFGKVELCRYDPEGDNTG 901 Query: 285 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSE--GTRRALIYEYMPNE 452 VAVK L+ +G + E+ + ++H NIV+ G C E G LI E++P+ Sbjct: 902 EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSG 961 Query: 453 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 SL++Y+ + + I+ K + L A+ I +GM+YL +++ +H D+ N+L+ Sbjct: 962 SLKEYLPKNKNKINLK-----QQLKYAIQICKGMDYLG---SRQYVHRDLAARNVLV 1010
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 64.7 bits (156), Expect = 2e-10 Identities = 44/137 (32%), Positives = 72/137 (52%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKG-----ELRNGVPVAVKMLESSTG--EGEEFINEVATIGLIHHANIVRL 392 LG G FG+VYKG + +PVA+K L +T +E ++E + + + ++ RL Sbjct: 720 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 779 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + LI + MP L Y+ H NI + L L+ + IA+GM YL Sbjct: 780 LGICLTSTVQ-LITQLMPYGCLLDYVREHKDNIGSQYL-----LNWCVQIAKGMNYLE-- 831 Query: 573 CNQRILHFDIKPHNILL 623 ++R++H D+ N+L+ Sbjct: 832 -DRRLVHRDLAARNVLV 847
>MERTK_MOUSE (Q60805) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 64.3 bits (155), Expect = 3e-10 Identities = 46/142 (32%), Positives = 71/142 (50%), Gaps = 12/142 (8%) Frame = +3 Query: 234 LGQGGFGSVYKGELRN----GVPVAVKMLES---STGEGEEFINEVATIGLIHHANIVRL 392 LG+G FGSV +G L+ VAVK ++ S E EEF++E A + +H N++RL Sbjct: 588 LGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRL 647 Query: 393 MGFCSEGTRRAL-----IYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +G C E + + + I +M L ++ N K + +L + IA+GME Sbjct: 648 LGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRLNTGPKYIHLQTLLKFMMDIAQGME 707 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL N+ LH D+ N +L Sbjct: 708 YL---SNRNFLHRDLAARNCML 726
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 64.3 bits (155), Expect = 3e-10 Identities = 40/141 (28%), Positives = 75/141 (53%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + ++ +G G FG VYKG L+ + VA+K L++ E + +F++E + +G H N Sbjct: 621 KIEEVIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPN 680 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 I+RL G ++ +I E+M N +L+ ++ + + +++ + GIA GM+Y Sbjct: 681 IIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 735 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L + +H D+ NIL+ Sbjct: 736 LSE---MNYVHRDLAARNILV 753
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 64.3 bits (155), Expect = 3e-10 Identities = 40/141 (28%), Positives = 75/141 (53%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + ++ +G G FG VYKG L+ + VA+K L++ E + +F++E + +G H N Sbjct: 538 KIEEVIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPN 597 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 I+RL G ++ +I E+M N +L+ ++ + + +++ + GIA GM+Y Sbjct: 598 IIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 652 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L + +H D+ NIL+ Sbjct: 653 LSE---MNYVHRDLAARNILV 670
>EGFR_HUMAN (P00533) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Receptor tyrosine-protein kinase ErbB-1) Length = 1210 Score = 64.3 bits (155), Expect = 3e-10 Identities = 44/137 (32%), Positives = 72/137 (52%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKG-----ELRNGVPVAVKMLESSTG--EGEEFINEVATIGLIHHANIVRL 392 LG G FG+VYKG + +PVA+K L +T +E ++E + + + ++ RL Sbjct: 718 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 777 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + LI + MP L Y+ H NI + L L+ + IA+GM YL Sbjct: 778 LGICLTSTVQ-LITQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQIAKGMNYLE-- 829 Query: 573 CNQRILHFDIKPHNILL 623 ++R++H D+ N+L+ Sbjct: 830 -DRRLVHRDLAARNVLV 845
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 64.3 bits (155), Expect = 3e-10 Identities = 43/141 (30%), Positives = 71/141 (50%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 R + +G G FG V G LR + VA+K L++ E + +F++E + +G H N Sbjct: 627 RIERVIGAGEFGEVCSGRLRLPSKREIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPN 686 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 I+RL G + ++ EYM N SL+ ++ H + ++L + GIA GM+Y Sbjct: 687 IIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFT-----VIQLLGMLRGIAAGMQY 741 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L + +H D+ NIL+ Sbjct: 742 LSE---MNYVHRDLAARNILV 759
>MERTK_HUMAN (Q12866) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 999 Score = 64.3 bits (155), Expect = 3e-10 Identities = 47/142 (33%), Positives = 70/142 (49%), Gaps = 12/142 (8%) Frame = +3 Query: 234 LGQGGFGSVYKGELRN----GVPVAVKMLE---SSTGEGEEFINEVATIGLIHHANIVRL 392 LG+G FGSV +G L+ + VAVK ++ SS E EEF++E A + H N++RL Sbjct: 593 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIRL 652 Query: 393 MGFCSEGTRRAL-----IYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +G C E + + + I +M L Y+ K + +L + IA GME Sbjct: 653 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME 712 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL N+ LH D+ N +L Sbjct: 713 YL---SNRNFLHRDLAARNCML 731
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 64.3 bits (155), Expect = 3e-10 Identities = 46/158 (29%), Positives = 71/158 (44%), Gaps = 5/158 (3%) Frame = +3 Query: 165 GTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGE-----G 329 G P F E++ ++ +G GGFG VY+ L G VAVK + Sbjct: 86 GLQLPQEIPFHELQ-----LEEIIGVGGFGKVYRA-LWRGEEVAVKAARLDPEKDPAVTA 139 Query: 330 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 509 E+ E G + H NI+ L G C L+ EY +L + + + + + Sbjct: 140 EQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-------AGRRVP 192 Query: 510 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 P +++ A+ +ARGM YLH I+H D+K NIL+ Sbjct: 193 PHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILI 230
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/172 (27%), Positives = 82/172 (47%), Gaps = 16/172 (9%) Frame = +3 Query: 156 KAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNG---VPVAVKMLE--SST 320 K PT Y + I +F+D +G+G FG V K ++ + A+K ++ +S Sbjct: 806 KVKNNPDPTIYPVLDWNDI--KFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK 863 Query: 321 GEGEEFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH------ 479 + +F E+ + L HH NI+ L+G C L EY P+ +L ++ Sbjct: 864 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETD 923 Query: 480 ----VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 ++N + L+ ++L A +ARGM+YL Q ++ +H D+ NIL+ Sbjct: 924 PAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARNILV 972
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 63.9 bits (154), Expect = 4e-10 Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKG-ELRNGVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +KLG G + +VYKG GV VA+K L+S G I E++ + + H NIVRL Sbjct: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + L++E+M N+ L+KY+ S + + L + + +G+ + H+ Sbjct: 71 VIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE--- 126 Query: 579 QRILHFDIKPHNILL 623 +ILH D+KP N+L+ Sbjct: 127 NKILHRDLKPQNLLI 141
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 63.9 bits (154), Expect = 4e-10 Identities = 49/177 (27%), Positives = 88/177 (49%), Gaps = 8/177 (4%) Frame = +3 Query: 96 YLSLKS---KYNEEINKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYK 266 Y+S+ S K +K ++ L G E++ F + +G G FG VYK Sbjct: 424 YVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIE-----FHEIIGSGSFGKVYK 478 Query: 267 GELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMGFC-SEGTRRALI 431 G RN + VA+K ++T + + F EV+ + ++H +++ +G C ++ ++ A++ Sbjct: 479 GRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 537 Query: 432 YEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDI 602 +Y+ SL + +++L L IA+ +ARGMEYLH Q I+H D+ Sbjct: 538 TQYISGGSLFSLLHE-----QKRILDLQSKLIIAVDVARGMEYLH-NLTQPIIHRDL 588
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 63.5 bits (153), Expect = 5e-10 Identities = 49/144 (34%), Positives = 73/144 (50%), Gaps = 13/144 (9%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMG 398 +LG GGFGSVYK +GVPVA+K + T F E+ GL H NIVR++ Sbjct: 99 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTEDLRASQRSFWAELNIAGL-RHDNIVRVVA 156 Query: 399 FCS-----EGTRRALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARG 551 + + +I E+ N +L + I+ + +K L+ K L +L + G Sbjct: 157 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVVNG 216 Query: 552 MEYLHQGCNQRILHFDIKPHNILL 623 + +LH +Q ILH D+KP NIL+ Sbjct: 217 LLFLH---SQSILHLDLKPANILI 237
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 63.5 bits (153), Expect = 5e-10 Identities = 40/141 (28%), Positives = 75/141 (53%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + ++ +G G FG VYKG L+ + VA+K L++ E + +F++E + +G H N Sbjct: 620 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPN 679 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 I+RL G ++ +I E+M N +L+ ++ + + +++ + GIA GM+Y Sbjct: 680 IIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 734 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L + +H D+ NIL+ Sbjct: 735 LSE---MNYVHRDLAARNILV 752
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 63.5 bits (153), Expect = 5e-10 Identities = 49/144 (34%), Positives = 73/144 (50%), Gaps = 13/144 (9%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMG 398 +LG GGFGSVYK +GVPVA+K + T F E+ GL H NIVR++ Sbjct: 79 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTEDLRASQRSFWAELNIAGL-RHDNIVRVVA 136 Query: 399 FCS-----EGTRRALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARG 551 + + +I E+ N +L + I+ + +K L+ K L +L + G Sbjct: 137 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVVNG 196 Query: 552 MEYLHQGCNQRILHFDIKPHNILL 623 + +LH +Q ILH D+KP NIL+ Sbjct: 197 LLFLH---SQSILHLDLKPANILI 217
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 63.5 bits (153), Expect = 5e-10 Identities = 42/136 (30%), Positives = 73/136 (53%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKG-ELRNGVPVAVKMLE-SSTGEGEEF--INEVATIGLIHHANIVRLM 395 +K+G+G +G VY+ ++ V VA+K + S EG I E++ + + H NIVRL+ Sbjct: 9 EKIGEGSYGVVYRARDITTDVIVALKRIRLESVEEGVPCTAIREISILKELRHENIVRLL 68 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 C R L++EYM + L+KY+ N L P + + + +G+ + H+ Sbjct: 69 DVCHSENRLNLVFEYMEMD-LKKYMDRASGN-----LDPATIQEFMRSLLKGVRFCHE-- 120 Query: 576 NQRILHFDIKPHNILL 623 + +LH D+KP N+L+ Sbjct: 121 -RNVLHRDLKPPNLLI 135
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 63.5 bits (153), Expect = 5e-10 Identities = 46/170 (27%), Positives = 83/170 (48%) Frame = +3 Query: 114 KYNEEINKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPV 293 K ++ + +++E + KP E+ + + + KLG G FG V+ G N V Sbjct: 212 KQSDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKV 271 Query: 294 AVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF 473 AVK L+ T + F+ E + + H +VRL ++ +I E+M SL ++ Sbjct: 272 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFL- 330 Query: 474 SHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 S+ K+L P K++D + IA GM Y+ + + +H D++ N+L+ Sbjct: 331 --KSDEGGKVLLP-KLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLV 374
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 63.5 bits (153), Expect = 5e-10 Identities = 40/142 (28%), Positives = 68/142 (47%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+K+ +LG G FG V G+ + VAVKM++ +EF E T+ + H Sbjct: 387 ELKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHP 446 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+ G CS+ ++ EY+ N L Y+ SH K L ++L++ + GM Sbjct: 447 KLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSH-----GKGLESCQLLEMCYDVCEGMA 501 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 +L + + +H D+ N L+ Sbjct: 502 FLE---SHQFIHRDLAARNCLV 520
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 63.2 bits (152), Expect = 6e-10 Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKG-ELRNGVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +K+G G + +VYKG GV VA+K L+S G I E++ + + H NIVRL Sbjct: 11 EKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLFD 70 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + L++E+M N+ L+K++ + S K L + + +G+ + H+ Sbjct: 71 VIHTENKLTLVFEFMDND-LKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHE--- 126 Query: 579 QRILHFDIKPHNILL 623 RILH D+KP N+L+ Sbjct: 127 NRILHRDLKPQNLLI 141
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 63.2 bits (152), Expect = 6e-10 Identities = 44/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +VRL SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVRLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 63.2 bits (152), Expect = 6e-10 Identities = 40/141 (28%), Positives = 74/141 (52%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + ++ +G G FG VYKG L+ + VA+K L++ E + +F++E + +G H N Sbjct: 620 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPN 679 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 I+RL G ++ +I E+M N +L+ ++ + + +++ + GIA GM+Y Sbjct: 680 IIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 734 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L +H D+ NIL+ Sbjct: 735 L---AEMNYVHRDLAARNILV 752
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 63.2 bits (152), Expect = 6e-10 Identities = 40/141 (28%), Positives = 74/141 (52%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + ++ +G G FG VYKG L+ + VA+K L++ E + +F++E + +G H N Sbjct: 620 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPN 679 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 I+RL G ++ +I E+M N +L+ ++ + + +++ + GIA GM+Y Sbjct: 680 IIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 734 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L +H D+ NIL+ Sbjct: 735 L---AEMNYVHRDLAARNILV 752
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 63.2 bits (152), Expect = 6e-10 Identities = 45/149 (30%), Positives = 69/149 (46%), Gaps = 19/149 (12%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVP------VAVKMLESSTGEG--EEFINEVATIGLIHHANIVR 389 +G+G FG V+ G + + VAVK L+ S + +F E + I HANIV Sbjct: 510 IGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIVT 569 Query: 390 LMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNIS-----------QKLLAPTKMLDIAL 536 G C+E + +I+E+M N L KY+ H + + + L +++ I L Sbjct: 570 FYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDRDSMDSDEGQLTREQLMKIVL 629 Query: 537 GIARGMEYLHQGCNQRILHFDIKPHNILL 623 IA MEYL Q +H D+ N L+ Sbjct: 630 QIASAMEYL---ALQHFVHRDLATRNCLV 655
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 63.2 bits (152), Expect = 6e-10 Identities = 42/142 (29%), Positives = 71/142 (50%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + + +LG G FG V+ G N VAVK L+ T + F+ E + + H Sbjct: 240 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 299 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +VRL + +I EYM SL ++ S+ K+L P K++D + IA GM Sbjct: 300 KLVRLYAVVTREEPIYIITEYMAKGSLLDFL---KSDEGGKVLLP-KLIDFSAQIAEGMA 355 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + + +H D++ N+L+ Sbjct: 356 YIER---KNYIHRDLRAANVLV 374
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 62.8 bits (151), Expect = 8e-10 Identities = 53/181 (29%), Positives = 80/181 (44%), Gaps = 32/181 (17%) Frame = +3 Query: 177 PTRYTFPEVKKIARRFKDKLGQGGFGSVYKGEL---------------RNGVP--VAVKM 305 P R FP + RFK+KLG+G FG V+ E+ R G P VAVK+ Sbjct: 600 PPRVDFPRSRL---RFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKI 656 Query: 306 L--ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH 479 L +++ +F+ EV + + NI+RL+G C + +I +YM N L +++ +H Sbjct: 657 LRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH 716 Query: 480 ---------VSNISQKLLAPT----KMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 620 Q PT +L +A IA GM YL +H D+ N L Sbjct: 717 QLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCL 773 Query: 621 L 623 + Sbjct: 774 V 774
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 62.8 bits (151), Expect = 8e-10 Identities = 46/145 (31%), Positives = 70/145 (48%), Gaps = 15/145 (10%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVP------VAVKMLESSTGEGEE--FINEVATIGLIHHANIVR 389 LGQG FG V++ VP VAVKML+ + + F E + H NIVR Sbjct: 447 LGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVR 506 Query: 390 LMGFCSEGTRRALIYEYMPNESLEKYI------FSHVSNISQKL-LAPTKMLDIALGIAR 548 L+G C+ G L++EYM L +++ +H + +L L +L +A IA Sbjct: 507 LLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAA 566 Query: 549 GMEYLHQGCNQRILHFDIKPHNILL 623 GM YL + ++ +H D+ N L+ Sbjct: 567 GMLYLSE---RKFVHRDLATRNCLI 588
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 62.8 bits (151), Expect = 8e-10 Identities = 44/140 (31%), Positives = 75/140 (53%), Gaps = 5/140 (3%) Frame = +3 Query: 219 RFK--DKLGQGGFGSVYKG-ELRNGVPVAVK--MLESSTGEGEEFINEVATIGLIHHANI 383 RFK ++LG G + +VYKG G+ VA+K L+S G I E++ + + H NI Sbjct: 8 RFKQLERLGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 67 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 VRL + L++E+M N+ L+K++ S + + L + + + +G+ + Sbjct: 68 VRLYDVIHTENKLTLVFEFMDND-LKKFMDSRLDREMPRGLELSLVKYFQWQLLQGVAFC 126 Query: 564 HQGCNQRILHFDIKPHNILL 623 H+ RILH D+KP N+L+ Sbjct: 127 HE---NRILHRDLKPQNLLI 143
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 62.8 bits (151), Expect = 8e-10 Identities = 46/164 (28%), Positives = 73/164 (44%), Gaps = 13/164 (7%) Frame = +3 Query: 171 SKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKML-----ESSTGEGEE 335 S P F ++ K+ +G GGFG VY+ + G VAVK + + E Sbjct: 114 SSPVHVAFERLE-----LKELIGAGGFGQVYRATWQ-GQEVAVKAARQDPEQDAAAAAES 167 Query: 336 FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPT 515 E ++ H NI+ L G C + L+ E+ +L + + + + + P Sbjct: 168 VRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPR 227 Query: 516 K--------MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + +++ A+ IARGM YLH+ ILH D+K NILL Sbjct: 228 RARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILL 271
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 62.8 bits (151), Expect = 8e-10 Identities = 47/154 (30%), Positives = 75/154 (48%), Gaps = 12/154 (7%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRN-------GVPVAVKMLE--SSTGEGEEFINEV 350 EV + + +LGQG FG VY+G + +PVAVK + +S + EF+ E Sbjct: 1031 EVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDRREFLKEA 1090 Query: 351 ATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDI 530 T+ H ++V+L+G S G +I E M L+ Y+ H + + P +LDI Sbjct: 1091 TTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDEDHPGVMPPHLLDI 1150 Query: 531 ---ALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 A IA GM YL +++ +H D+ N ++ Sbjct: 1151 LQMAGEIADGMAYL---ADKKFVHRDLAARNCMV 1181
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 62.8 bits (151), Expect = 8e-10 Identities = 43/142 (30%), Positives = 71/142 (50%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G + VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVIEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 62.8 bits (151), Expect = 8e-10 Identities = 53/181 (29%), Positives = 80/181 (44%), Gaps = 32/181 (17%) Frame = +3 Query: 177 PTRYTFPEVKKIARRFKDKLGQGGFGSVYKGEL---------------RNGVP--VAVKM 305 P R FP + RFK+KLG+G FG V+ E+ R G P VAVK+ Sbjct: 596 PPRVDFPRSRL---RFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKI 652 Query: 306 L--ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH 479 L +++ +F+ EV + + NI+RL+G C + +I +YM N L +++ +H Sbjct: 653 LRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH 712 Query: 480 ---------VSNISQKLLAPT----KMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 620 Q PT +L +A IA GM YL +H D+ N L Sbjct: 713 QLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCL 769 Query: 621 L 623 + Sbjct: 770 V 770
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 62.4 bits (150), Expect = 1e-09 Identities = 52/176 (29%), Positives = 81/176 (46%), Gaps = 19/176 (10%) Frame = +3 Query: 153 LKAYGTSKPTRYTFPEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VAVKM 305 LK+ P + V + RR K +LG+G FG V+ E + +P VAVK Sbjct: 469 LKSNFIENPQYFCNACVHHVQRRDIVLKWELGEGAFGKVFLAECSHLLPEQEKTLVAVKA 528 Query: 306 LESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH- 479 L+ T +F E + ++ H +IV+ G C+EG +++EYM + L +++ SH Sbjct: 529 LKEVTENARLDFQREAELLTVLQHEHIVKFYGVCTEGDPLIMVFEYMKHGDLNRFLRSHG 588 Query: 480 --VSNISQKLLAP------TKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + Q P + ML IA IA GM YL + +H D+ N L+ Sbjct: 589 PDAKILDQGQGQPCGQLTLSHMLQIATQIASGMVYL---ASLHFVHRDLATRNCLV 641
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 62.4 bits (150), Expect = 1e-09 Identities = 44/149 (29%), Positives = 74/149 (49%), Gaps = 16/149 (10%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRN------GVPVAVKML-ESSTGEGEEFINEVATIGLIHHANI 383 K +LG+G FG V+ E N + VAVK L E+S ++F E + ++ H +I Sbjct: 516 KWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHI 575 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSH---------VSNISQKLLAPTKMLDIAL 536 VR G C+EG +++EYM + L +++ SH +++ L ++L +A Sbjct: 576 VRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 635 Query: 537 GIARGMEYLHQGCNQRILHFDIKPHNILL 623 +A GM YL + +H D+ N L+ Sbjct: 636 QVAAGMVYL---ASLHFVHRDLATRNCLV 661
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 62.4 bits (150), Expect = 1e-09 Identities = 41/132 (31%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+V++G V V V K+ + + + + F NE+ + H NI+ MGF + Sbjct: 315 RIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMT 374 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 A+I ++ SL Y HV++ ++ +++D+A A+GM+YLH + I Sbjct: 375 R-PGFAIITQWCEGSSL--YHHLHVADTRFDMV---QLIDVARQTAQGMDYLHA---KNI 425 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 426 IHRDLKSNNIFL 437
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 62.4 bits (150), Expect = 1e-09 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGE-GEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+V++G V V V + T E + F NE+ + H NI+ MGF + Sbjct: 315 RIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMT 374 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 A+I ++ SL Y HV++ ++ +++D+A A+GM+YLH + I Sbjct: 375 R-PGFAIITQWCEGSSL--YHHLHVADTRFDMV---QLIDVARQTAQGMDYLHA---KNI 425 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 426 IHRDLKSNNIFL 437
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.4 bits (150), Expect = 1e-09 Identities = 41/132 (31%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+V++G V V V K+ + + + + F NE+ + H NI+ MGF + Sbjct: 313 RIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMT 372 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 A+I ++ SL Y HV++ ++ +++D+A A+GM+YLH + I Sbjct: 373 R-PGFAIITQWCEGSSL--YHHLHVADTRFDMV---QLIDVARQTAQGMDYLHA---KNI 423 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 424 IHRDLKSNNIFL 435
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.4 bits (150), Expect = 1e-09 Identities = 41/132 (31%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAV-KMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 ++G G FG+V++G V V V K+ + + + + F NE+ + H NI+ MGF + Sbjct: 313 RIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMT 372 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 A+I ++ SL Y HV++ ++ +++D+A A+GM+YLH + I Sbjct: 373 R-PGFAIITQWCEGSSL--YHHLHVADTRFDMV---QLIDVARQTAQGMDYLHA---KNI 423 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 424 IHRDLKSNNIFL 435
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 62.4 bits (150), Expect = 1e-09 Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 9/142 (6%) Frame = +3 Query: 225 KDK-LGQGGFGSVYKGELRN------GVPVAVKMLESSTGE--GEEFINEVATIGLIHHA 377 KD+ LG G FG+VYKG L N +PVA+K+L +T +E ++E + + H Sbjct: 712 KDRVLGSGAFGTVYKG-LWNPDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVDHP 770 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 ++ RL+G C + L+ + MP L Y+ H Q+ + +L+ + IA+GM Sbjct: 771 HVCRLLGICLTSAVQ-LVTQLMPYGCLLDYVRQH-----QERICGQWLLNWCVQIAKGMN 824 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL + + ++H D+ N+LL Sbjct: 825 YLEE---RHLVHRDLAARNVLL 843
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 62.4 bits (150), Expect = 1e-09 Identities = 40/132 (30%), Positives = 71/132 (53%), Gaps = 1/132 (0%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPV-AVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS 407 K+G G FG+VY+GE V + + +++ + + F NEVA + H N++ MG+ Sbjct: 486 KVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVR 545 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 E A+I ++ SL ++I + ++ A ++DI ++ GM YLH ++ I Sbjct: 546 E-PEIAIITQWCEGSSLYRHIHVQEPRVEFEMGA---IIDILKQVSLGMNYLH---SKNI 598 Query: 588 LHFDIKPHNILL 623 +H D+K +NI L Sbjct: 599 IHRDLKTNNIFL 610
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 62.4 bits (150), Expect = 1e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVIEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVAVKML---ESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +K+G+G +G VYK + +G A+K + E G I E++ + +HH NIV L Sbjct: 8 EKIGEGTYGVVYKAQNNHGEICALKKIRVEEEDEGIPSTAIREISLLKELHHPNIVWLRD 67 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 L++EY+ ++ L+K + + L PT I RG+ Y H + Sbjct: 68 VIHSEKCLTLVFEYL-DQDLKKLL-----DACDGGLEPTTAKSFLYQILRGISYCH---D 118 Query: 579 QRILHFDIKPHNILL 623 RILH D+KP N+L+ Sbjct: 119 HRILHRDLKPQNLLI 133
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVAVKML---ESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +K+G+G +G VYK + +G A+K + E G I E++ + +HH NIV L Sbjct: 8 EKIGEGTYGVVYKAQNNHGEICALKKIRVEEEDEGIPSTAIREISLLKELHHPNIVWLRD 67 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 L++EY+ ++ L+K + + L PT I RG+ Y H + Sbjct: 68 VIHSEKCLTLVFEYL-DQDLKKLL-----DACDGGLEPTTAKSFLYQILRGISYCH---D 118 Query: 579 QRILHFDIKPHNILL 623 RILH D+KP N+L+ Sbjct: 119 HRILHRDLKPQNLLI 133
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHK 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVIEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR-NGVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +KLG+G + +VYKG R G VA+K L+S G I E++ + + H NIV L Sbjct: 12 EKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKELDHENIVTLYD 71 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + L++EYM ++ L+KY+ H Q L + + +G+ + H + Sbjct: 72 VIHTENKLTLVFEYM-DKDLKKYMEVHG---QQSALDLKVVKSFMFQLLKGIMFCH---D 124 Query: 579 QRILHFDIKPHNILL 623 R+LH D+KP N+L+ Sbjct: 125 NRVLHRDLKPQNLLI 139
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/139 (30%), Positives = 66/139 (47%), Gaps = 6/139 (4%) Frame = +3 Query: 225 KDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE------EFINEVATIGLIHHANIV 386 K+ +G GGF V++G +G VA+K+ TGE + + E + H NI Sbjct: 145 KEVIGSGGFCKVHRGYY-DGEEVAIKIAHQ-TGEDDMQRMRDNVLQEAKLFWALKHENIA 202 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLH 566 L G C T+ L+ EY SL + + + P +++ A+ IARGM YLH Sbjct: 203 ALRGVCLN-TKLCLVMEYARGGSLNRILAGKIP--------PDVLVNWAIQIARGMNYLH 253 Query: 567 QGCNQRILHFDIKPHNILL 623 I+H D+K N+L+ Sbjct: 254 NEAPMSIIHRDLKSSNVLI 272
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 62.0 bits (149), Expect = 1e-09 Identities = 54/185 (29%), Positives = 85/185 (45%), Gaps = 12/185 (6%) Frame = +3 Query: 105 LKSKYNEEINKKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRNG 284 L + N E EM++ P ++ P K R +LGQG FG VY+G + Sbjct: 968 LYASVNPEYFSAAEMYV-------PDKWEVPREKITMNR---ELGQGSFGMVYEGIAKGV 1017 Query: 285 VP------VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEY 440 V VA+K + + E EF+NE + + + ++VRL+G S+G +I E Sbjct: 1018 VKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMEL 1077 Query: 441 MPNESLEKYIFS----HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKP 608 M L+ Y+ S SN Q + KM+ +A IA GM YL+ + +H D+ Sbjct: 1078 MTRGDLKSYLRSLRPDTESNSGQPTPSLKKMIQMAGEIADGMSYLNA---NKFVHRDLAA 1134 Query: 609 HNILL 623 N ++ Sbjct: 1135 RNCMV 1139
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/137 (32%), Positives = 71/137 (51%), Gaps = 7/137 (5%) Frame = +3 Query: 234 LGQGGFGSVYKG-----ELRNGVPVAVKMLESSTG--EGEEFINEVATIGLIHHANIVRL 392 LG G FG+VYKG + +PVA+K L +T +E ++E + + + ++ RL Sbjct: 138 LGFGAFGTVYKGLWIPEGEKVTIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 197 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 +G C T + LI + MP L YI H NI + L L+ + IA+GM YL + Sbjct: 198 LGICLTSTVQ-LITQLMPYGCLLDYIREHKDNIGSQYL-----LNWCVQIAKGMNYLEE- 250 Query: 573 CNQRILHFDIKPHNILL 623 + ++H D+ N+L+ Sbjct: 251 --RHMVHRDLAARNVLV 265
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/135 (31%), Positives = 73/135 (54%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR-NGVPVAVKM--LESSTGEGEEFINEVATIGLIHHANIVRLMG 398 +KLG+G + +VYKG R NG VA+K L+S G I E++ + + H NIV L Sbjct: 12 EKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIREISLMKELDHENIVTLYD 71 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + L++E+M ++ L+KY+ +H +Q L + + +G+ + H + Sbjct: 72 VIHTENKLTLVFEFM-DKDLKKYMEAHG---NQGALDLKIVKSFIFQLLKGIMFCH---D 124 Query: 579 QRILHFDIKPHNILL 623 R+LH D+KP N+L+ Sbjct: 125 NRVLHRDLKPQNLLI 139
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 2e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 2e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 61.6 bits (148), Expect = 2e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 61.6 bits (148), Expect = 2e-09 Identities = 49/186 (26%), Positives = 92/186 (49%), Gaps = 15/186 (8%) Frame = +3 Query: 111 SKYNEEINKKVEMFLKAYGTSKPTRYTFPE--VKKIAR-------RFKDKLGQGGFGSVY 263 S+Y E++ + + +K Y P Y P V++ A+ + ++ +G G FG V Sbjct: 591 SEYTEKLQQYIAPGMKVY--IDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVC 648 Query: 264 KGEL----RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRA 425 +G L R V VA+K L+ E + +F++E + +G H NI+RL G ++ Sbjct: 649 RGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVM 708 Query: 426 LIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIK 605 ++ E+M N +L+ ++ ++ +++ + GIA GM+YL + +H D+ Sbjct: 709 ILTEFMENCALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKYLSE---MNYVHRDLA 760 Query: 606 PHNILL 623 NIL+ Sbjct: 761 ARNILV 766
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 61.6 bits (148), Expect = 2e-09 Identities = 40/136 (29%), Positives = 69/136 (50%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G G V G L+ VPVA+K L++ E + +F++E A +G H NI+RL Sbjct: 640 IGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLE 699 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G + G ++ EYM N SL+ ++ +H + +++ + G+ GM YL Sbjct: 700 GVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFT-----IVQLVGMLRGVGAGMRYL---S 751 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ N+L+ Sbjct: 752 DLGYIHRDLAARNVLV 767
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 61.6 bits (148), Expect = 2e-09 Identities = 41/142 (28%), Positives = 69/142 (48%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E++K + LG G FG V++G VAVK L+ T EEF+ E + + + H Sbjct: 234 EIEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSIEEFLEEASIMKQLRHP 293 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +++L C++ ++ E M + SL +Y+ + L ++D+ +A GM Sbjct: 294 KLIQLYAVCTKEEPIYIVTELMKHGSLLEYLRG-----DGRSLKLPDLVDMCSQVASGMS 348 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 YL Q Q +H D+ NIL+ Sbjct: 349 YLEQ---QNYIHRDLAARNILV 367
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 61.6 bits (148), Expect = 2e-09 Identities = 40/136 (29%), Positives = 69/136 (50%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G G V G LR VPVA+K L++ E + +F++E + +G H NI+RL Sbjct: 641 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLE 700 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G + G ++ EYM N SL+ ++ +H + +++ + G+ GM YL Sbjct: 701 GVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFT-----IMQLVGMLRGVGAGMRYL---S 752 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ N+L+ Sbjct: 753 DLGYVHRDLAARNVLV 768
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 61.6 bits (148), Expect = 2e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 61.6 bits (148), Expect = 2e-09 Identities = 46/134 (34%), Positives = 71/134 (52%), Gaps = 3/134 (2%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVK-MLESSTGEGE--EFINEVATIGLIHHANIVRLMGF 401 ++G G +G V+ G+ + GV VAVK ++ E + EF E+A + + H+NIV +G Sbjct: 1369 QIGLGSYGIVFNGKWK-GVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGA 1427 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C + ++ EYM +L + N K+ K L + G A G++YLH N Sbjct: 1428 CIKKPNICIVTEYMRMGNLRDVL----KNPDIKITFANK-LKLLYGAAMGIDYLHSS-NP 1481 Query: 582 RILHFDIKPHNILL 623 I+H DIKP NIL+ Sbjct: 1482 MIVHRDIKPANILV 1495 Score = 52.8 bits (125), Expect = 8e-07 Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVAVKMLES---STGEGEEFINEVATIGLIHHANIVRLMG 398 + LG GG+G VYK + G VAVK++ S S F EV + + H N+V M Sbjct: 790 ETLGTGGYGEVYKS-IWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMA 848 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 ++ ++ E+M SL + + N + + +A ++GM +LH + Sbjct: 849 ASTKSPNMCIVMEFMSLGSL----YDLLGNELIPEIPYALKIKMAYQASKGMHFLH---S 901 Query: 579 QRILHFDIKPHNILL 623 I+H D+K N+LL Sbjct: 902 SGIVHRDLKSLNLLL 916
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 61.6 bits (148), Expect = 2e-09 Identities = 42/136 (30%), Positives = 72/136 (52%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G+G FG VY+G LR + VA+K L+ ++ +G F+ E +G +H +I+RL Sbjct: 631 IGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLE 690 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ +I E+M N +L+ ++ + LAP +++ + LGIA GM L Sbjct: 691 GVITKRKPIMIITEFMENGALDAFLKER-----EDQLAPGQLVAMLLGIASGMNCL---S 742 Query: 576 NQRILHFDIKPHNILL 623 +H D+ NIL+ Sbjct: 743 GHNYVHRDLAARNILV 758
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 61.6 bits (148), Expect = 2e-09 Identities = 43/142 (30%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 260 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 319 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++D+A IA GM Sbjct: 320 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----KYLRLPQLVDMAAQIASGMA 374 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 375 YVER---MNYVHRDLRAANILV 393
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/136 (30%), Positives = 68/136 (50%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G G V G L+ VPVA+K L++ E + +F+ E A +G H NI+RL Sbjct: 8 IGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLREAAIMGQFDHPNIIRLE 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G + G ++ EYM N SL+ ++ +H + +++ + G+ GM YL Sbjct: 68 GVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFT-----ILQLVGMLKGVGAGMRYL---S 119 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ NIL+ Sbjct: 120 DLGYIHRDLAARNILV 135
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 12/143 (8%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGE---GEEFINEVATIGLIHHANIVRLMGF 401 +LG GGFGSVYK +GVPVA+K + T + + I + H NIVR++ Sbjct: 99 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAA 157 Query: 402 CS-----EGTRRALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARGM 554 + + +I E+ N +L + I+ + ++ L+ K L +L + G+ Sbjct: 158 STRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGL 217 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 +LH +Q ILH D+KP NIL+ Sbjct: 218 LFLH---SQSILHLDLKPANILI 237
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 12/143 (8%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGE---GEEFINEVATIGLIHHANIVRLMGF 401 +LG GGFGSVYK +GVPVA+K + T + + I + H NIVR++ Sbjct: 68 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAA 126 Query: 402 CS-----EGTRRALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARGM 554 + + +I E+ N +L + I+ + ++ L+ K L +L + G+ Sbjct: 127 STRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGL 186 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 +LH +Q ILH D+KP NIL+ Sbjct: 187 LFLH---SQSILHLDLKPANILI 206
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 61.2 bits (147), Expect = 2e-09 Identities = 43/142 (30%), Positives = 69/142 (48%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 263 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 322 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ K L +++D+A IA GM Sbjct: 323 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETG----KYLRLPQLVDMAAQIASGMA 377 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 378 YVER---MNYVHRDLRAANILV 396
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 61.2 bits (147), Expect = 2e-09 Identities = 49/158 (31%), Positives = 80/158 (50%), Gaps = 7/158 (4%) Frame = +3 Query: 171 SKPTRYTF---PEVKKIARR---FKDKLGQGGFGSVYKGEL-RNGVPVAVKMLESSTGEG 329 +KPT + P+ +I R K KLG G +G VY+ R G VAVK L+ T Sbjct: 350 NKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMAL 409 Query: 330 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 509 ++F+ E A + + H N+V+L+G C+ +I E+M + +L ++ S ++ L Sbjct: 410 KDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS----AGRETLD 465 Query: 510 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +L +A IA GM YL ++ +H D+ N L+ Sbjct: 466 AVALLYMATQIASGMSYLE---SRNYIHRDLAARNCLV 500
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 12/143 (8%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGE---GEEFINEVATIGLIHHANIVRLMGF 401 +LG GGFGSVYK +GVPVA+K + T + + I + H NIVR++ Sbjct: 99 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAA 157 Query: 402 CS-----EGTRRALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARGM 554 + + +I E+ N +L + I+ + ++ L+ K L +L + G+ Sbjct: 158 STRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGL 217 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 +LH +Q ILH D+KP NIL+ Sbjct: 218 LFLH---SQSILHLDLKPANILI 237
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 12/143 (8%) Frame = +3 Query: 231 KLGQGGFGSVYKGELRNGVPVAVKMLESSTGE---GEEFINEVATIGLIHHANIVRLMGF 401 +LG GGFGSVYK +GVPVA+K + T + + I + H NIVR++ Sbjct: 115 RLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAA 173 Query: 402 CS-----EGTRRALIYEYMPNESLEKYIFSHVSN----ISQKLLAPTKMLDIALGIARGM 554 + + +I E+ N +L + I+ + ++ L+ K L +L + G+ Sbjct: 174 STRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGL 233 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 +LH +Q ILH D+KP NIL+ Sbjct: 234 LFLH---SQSILHLDLKPANILI 253
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 61.2 bits (147), Expect = 2e-09 Identities = 47/185 (25%), Positives = 89/185 (48%), Gaps = 15/185 (8%) Frame = +3 Query: 114 KYNEEINKKVEMFLKAYGTSKPTRYTFPE--VKKIAR-------RFKDKLGQGGFGSVYK 266 +Y E++ + V +K Y P Y P V + AR + ++ +G G FG V + Sbjct: 146 EYTEKLQQYVSPGVKVY--IDPFTYEDPNEAVHEFAREIDISCVKIEEVIGAGEFGEVCR 203 Query: 267 GEL----RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRAL 428 G L R VA+K L++ E + +F++E + +G H N++ L G + + Sbjct: 204 GRLKQAGRKETTVAIKTLKAGYTEHQRRDFLSEASIMGQFDHPNVIHLEGVLTRSCPVLI 263 Query: 429 IYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKP 608 + E+M N +L+ ++ ++ T+++ + GIA GM+YL + +H D+ Sbjct: 264 VTEFMENGALDSFL-----RLNDGRFTVTQLVGMLRGIAAGMKYL---SDMNYVHRDLAA 315 Query: 609 HNILL 623 N+L+ Sbjct: 316 RNVLV 320
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/136 (30%), Positives = 70/136 (51%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G+G FG VY+G LR + VA+K L+ ++ G+ F+ E +G H +I+ L Sbjct: 630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLE 689 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ +I E+M N +L+ ++ + L P +++ + GIA GM YL Sbjct: 690 GVVTKRKPIMIITEFMENGALDAFLRER-----EDQLVPGQLVAMLQGIASGMNYL---S 741 Query: 576 NQRILHFDIKPHNILL 623 N +H D+ NIL+ Sbjct: 742 NHNYVHRDLAARNILV 757
>MERTK_RAT (P57097) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/143 (31%), Positives = 76/143 (53%), Gaps = 13/143 (9%) Frame = +3 Query: 234 LGQGGFGSVYKGELRN----GVPVAVKMLES---STGEGEEFINEVATIGLIHHANIVRL 392 LG+G FGSV +G L+ VAVK ++ S E EEF++E A + +H N++RL Sbjct: 588 LGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFNHPNVIRL 647 Query: 393 MGFCSEGTRRAL-----IYEYMPNESLEKY-IFSHVSNISQKLLAPTKMLDIALGIARGM 554 +G C E + + + I +M L + ++S + ++ + + T +L + IA+GM Sbjct: 648 LGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRIESVPKSIPLQT-LLKFMVDIAQGM 706 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 EYL ++ LH D+ N +L Sbjct: 707 EYL---SSRNFLHRDLAARNCML 726
>ROR2_HUMAN (Q01974) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Length = 943 Score = 60.8 bits (146), Expect = 3e-09 Identities = 47/161 (29%), Positives = 77/161 (47%), Gaps = 19/161 (11%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVP------VAVKMLESSTGEG---EEFINEV 350 E+ A RF ++LG+ FG VYKG L P VA+K L+ EG EEF +E Sbjct: 467 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDK-AEGPLREEFRHEA 525 Query: 351 ATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIF--SHVSNIS--------QK 500 + H N+V L+G ++ ++I+ Y + L +++ S S++ + Sbjct: 526 MLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 585 Query: 501 LLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L P + + IA GMEYL + ++H D+ N+L+ Sbjct: 586 ALEPPDFVHLVAQIAAGMEYL---SSHHVVHKDLATRNVLV 623
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/136 (30%), Positives = 75/136 (55%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG ++ G VA+K + + G + EV+ + + H N+VRL+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + +R LI+E++ + L+KY+ S S + + P + I G+ + H+ Sbjct: 68 DVLMQESRLYLIFEFL-SMDLKKYLDSIPSG---QYMDPMLVKSYLYQILEGIYFCHR-- 121 Query: 576 NQRILHFDIKPHNILL 623 +R+LH D+KP N+L+ Sbjct: 122 -RRVLHRDLKPQNLLI 136
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/136 (30%), Positives = 75/136 (55%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG ++ G VA+K + + G + EV+ + + H N+VRL+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + +R LI+E++ + L+KY+ S S + + P + I G+ + H+ Sbjct: 68 DVLMQESRLYLIFEFL-SMDLKKYLDSIPSG---QYMDPMLVKSYLYQILEGIYFCHR-- 121 Query: 576 NQRILHFDIKPHNILL 623 +R+LH D+KP N+L+ Sbjct: 122 -RRVLHRDLKPQNLLI 136
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/136 (30%), Positives = 75/136 (55%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG ++ G VA+K + + G + EV+ + + H N+VRL+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + +R LI+E++ + L+KY+ S S + + P + I G+ + H+ Sbjct: 68 DVLMQESRLYLIFEFL-SMDLKKYLDSIPSG---QYMDPMLVKSYLYQILEGIYFCHR-- 121 Query: 576 NQRILHFDIKPHNILL 623 +R+LH D+KP N+L+ Sbjct: 122 -RRVLHRDLKPQNLLI 136
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/136 (30%), Positives = 75/136 (55%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG ++ G VA+K + + G + EV+ + + H N+VRL+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + +R LI+E++ + L+KY+ S S + + P + I G+ + H+ Sbjct: 68 DVLMQESRLYLIFEFL-SMDLKKYLDSIPSG---QYMDPMLVKSYLYQILEGIYFCHR-- 121 Query: 576 NQRILHFDIKPHNILL 623 +R+LH D+KP N+L+ Sbjct: 122 -RRVLHRDLKPQNLLI 136
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 60.8 bits (146), Expect = 3e-09 Identities = 42/142 (29%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 257 EIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 316 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + K L +++++A IA GM Sbjct: 317 KLVQLYAMVSE-EPIYIVIEYMSKGSLLDFLKGEMG----KYLRLPQLVEMAAQIASGMA 371 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 372 YVER---MNYVHRDLRAANILV 390
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 60.8 bits (146), Expect = 3e-09 Identities = 39/134 (29%), Positives = 65/134 (48%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F +LG G FG V G+ R VA+KM++ + +EFI E + + H +V+L G Sbjct: 403 FLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGV 462 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C++ +I EYM N L Y+ + ++L++ + MEYL ++ Sbjct: 463 CTKQRPIFIITEYMANGCLLNYL-----REMRHRFQTQQLLEMCKDVCEAMEYLE---SK 514 Query: 582 RILHFDIKPHNILL 623 + LH D+ N L+ Sbjct: 515 QFLHRDLAARNCLV 528
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 60.8 bits (146), Expect = 3e-09 Identities = 40/136 (29%), Positives = 69/136 (50%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G FG V G L+ + VA+K L+ E + +F+ E + +G H NI+RL Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ ++ EYM N SL+ ++ H + + +++ + GIA GM+YL Sbjct: 687 GVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---S 738 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ NIL+ Sbjct: 739 DMGYVHRDLAARNILI 754
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 60.8 bits (146), Expect = 3e-09 Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G FG V G L+ + VA+K L++ E + +F+ E + +G H NI+RL Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ ++ EYM N SL+ ++ H + + +++ + GIA GM+YL Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---S 738 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ NIL+ Sbjct: 739 DMGYVHRDLAARNILI 754
>SHARK_DROME (Q24145) Tyrosine-protein kinase shark (EC 2.7.10.2)| Length = 939 Score = 60.8 bits (146), Expect = 3e-09 Identities = 44/139 (31%), Positives = 69/139 (49%), Gaps = 8/139 (5%) Frame = +3 Query: 231 KLGQGGFGSVYKGEL--------RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIV 386 ++G G FGSV+ G L + + VA+KML +EF+ E + + + H IV Sbjct: 667 EIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIV 726 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLH 566 RL+G ++G ++ E P S+ +YI H ++ A ++ A IA GM YL Sbjct: 727 RLIGI-AKGEMLMMVQELAPLGSMLQYILDH----GHEITANAELKVWASQIACGMHYLE 781 Query: 567 QGCNQRILHFDIKPHNILL 623 +Q +H D+ NILL Sbjct: 782 ---SQHFVHRDLAARNILL 797
>UFO_HUMAN (P30530) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (AXL oncogene) Length = 887 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/144 (31%), Positives = 76/144 (52%), Gaps = 14/144 (9%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNG---VPVAVKMLE---SSTGEGEEFINEVATIGLIHHANIVRLM 395 LG+G FG+V +G+L + VAVK ++ + E E+F++E + H N++RL+ Sbjct: 535 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 594 Query: 396 GFCSEGTRR------ALIYEYMPNESLEKY-IFSHVSNISQKLLAPTKML-DIALGIARG 551 G C +G+ R +I +M + L + ++S + + Q + PT+ML IA G Sbjct: 595 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGD--QPVYLPTQMLVKFMADIASG 652 Query: 552 MEYLHQGCNQRILHFDIKPHNILL 623 MEYL +R +H D+ N +L Sbjct: 653 MEYL---STKRFIHRDLAARNCML 673
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 60.5 bits (145), Expect = 4e-09 Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 5/135 (3%) Frame = +3 Query: 234 LGQGGFGSVYKGE-LRNGVPVAVKMLE----SSTGEGEEFINEVATIGLIHHANIVRLMG 398 LG GG G VY GE + G VA+K+L + G E F E + + H +VR++ Sbjct: 19 LGSGGMGEVYLGEQVSLGRKVAIKVLHHDLHAQAGMAERFKREARLLSAVEHPAVVRIVD 78 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 F G L+ E++ ESL ++ + P + L + +A G+ +H + Sbjct: 79 FGESGDHACLVMEFVEGESL-------YDVLTPGPMPPGRALPLLQQLAEGLAAIH---D 128 Query: 579 QRILHFDIKPHNILL 623 + I+H D+KP N+ + Sbjct: 129 KGIIHRDLKPENVFI 143
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 60.5 bits (145), Expect = 4e-09 Identities = 43/136 (31%), Positives = 74/136 (54%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYK R G VA+K + T G I E++ + ++H NIV+L+ Sbjct: 8 EKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + L++E++ N+ L+K++ SNIS LA K + +G+ + H Sbjct: 68 DVIHTENKLYLVFEFL-NQDLKKFMDG--SNISGISLALVK--SYLFQLLQGLAFCH--- 119 Query: 576 NQRILHFDIKPHNILL 623 + R+LH D+KP N+L+ Sbjct: 120 SHRVLHRDLKPQNLLI 135
>UFO_MOUSE (Q00993) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (Adhesion-related kinase) Length = 888 Score = 60.5 bits (145), Expect = 4e-09 Identities = 45/144 (31%), Positives = 76/144 (52%), Gaps = 14/144 (9%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNG---VPVAVKMLE---SSTGEGEEFINEVATIGLIHHANIVRLM 395 LG+G FG+V +G+L + VAVK ++ + E E+F++E + H N++RL+ Sbjct: 536 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 595 Query: 396 GFCSEGTRR------ALIYEYMPNESLEKY-IFSHVSNISQKLLAPTKML-DIALGIARG 551 G C +G+ R +I +M + L + ++S + + Q + PT+ML IA G Sbjct: 596 GVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGD--QPVFLPTQMLVKFMADIASG 653 Query: 552 MEYLHQGCNQRILHFDIKPHNILL 623 MEYL +R +H D+ N +L Sbjct: 654 MEYL---STKRFIHRDLAARNCML 674
>CDC2H_CRIFA (Q01917) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 474 Score = 60.5 bits (145), Expect = 4e-09 Identities = 49/136 (36%), Positives = 75/136 (55%), Gaps = 5/136 (3%) Frame = +3 Query: 231 KLGQGGFGSVYKG-ELRNGVPVAVK-MLESSTGEG--EEFINEVATIGLIHHANIVRLMG 398 KLG+G +G VYKG E++ G VA K M+ +S EG I E+ + + H N+V L Sbjct: 12 KLGEGTYGMVYKGTEIQTGRVVAFKRMVVTSDDEGIPGAAIREICLLKELRHNNVVELFE 71 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL-APTKMLDIALGIARGMEYLHQGC 575 + + +I+E + + L++Y+ S Q+LL A T+M I I G+EYLH C Sbjct: 72 VLFDPPKITMIFE-LCDCDLKRYMESR----PQRLLDANTEMRPILKQIFLGLEYLHGRC 126 Query: 576 NQRILHFDIKPHNILL 623 ++H D+KP NI + Sbjct: 127 ---VVHRDMKPQNIFV 139
>RYK_AVIR3 (P33497) Tyrosine-protein kinase transforming protein RYK (EC| 2.7.10.1) Length = 442 Score = 60.5 bits (145), Expect = 4e-09 Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 14/177 (7%) Frame = +3 Query: 135 KKVEMFLKAYGTSKPTRYTFPEV--KKIARRFKDKLGQGGFGSVYKGELRN--GVP--VA 296 + VE+ L + G S + +V + A LG+G FGSV +G L G P VA Sbjct: 16 RAVELTLGSLGVSSELQQKLQDVVIDRNALSLGKVLGEGEFGSVMEGRLSQPEGTPQKVA 75 Query: 297 VKMLES---STGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRAL-----IYEYMPNE 452 VK ++ S E EEF++E A I H N+++L+G C E + + + + +M Sbjct: 76 VKTMKLDNFSHREIEEFLSEAACIKDFDHPNVIKLLGVCIELSSQQIPKPMVVLPFMKYG 135 Query: 453 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L ++ ++ + + +L + IA GMEYL +++ LH D+ N +L Sbjct: 136 DLHSFLLRSRLEMAPQFVPLQMLLKFMVDIALGMEYL---SSRQFLHRDLAARNCML 189
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 60.5 bits (145), Expect = 4e-09 Identities = 43/151 (28%), Positives = 75/151 (49%), Gaps = 21/151 (13%) Frame = +3 Query: 234 LGQGGFGSVYKGEL--------RNGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHAN 380 LG+G FG V E + V VAVKML+ + E + + ++E+ + +I H N Sbjct: 477 LGEGCFGQVVMAEALGIDKERPKESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKN 536 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH----------VSNISQKLLAPTKMLDI 530 I+ L+G C++G +I EY +L +Y+ + V+ + + + ++ Sbjct: 537 IINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSC 596 Query: 531 ALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 IARGMEYL +Q+ +H D+ N+L+ Sbjct: 597 TYQIARGMEYL---ASQKCIHRDLAARNVLV 624
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 60.5 bits (145), Expect = 4e-09 Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 5/135 (3%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGEG-----EEFINEVATIGLIHHANIVRLMG 398 +G GGFG VY+ G VAVK E E E ++ H NI+ L G Sbjct: 150 IGIGGFGKVYRA-FWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRG 208 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 C + L+ E+ L + + S K + P +++ A+ IARGM YLH Sbjct: 209 VCLKEPNLCLVMEFARGGPLNRVL-------SGKRIPPDILVNWAVQIARGMNYLHDEAI 261 Query: 579 QRILHFDIKPHNILL 623 I+H D+K NIL+ Sbjct: 262 VPIIHRDLKSSNILI 276
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 60.5 bits (145), Expect = 4e-09 Identities = 48/186 (25%), Positives = 92/186 (49%), Gaps = 15/186 (8%) Frame = +3 Query: 111 SKYNEEINKKVEMFLKAYGTSKPTRYTFPE--VKKIAR-------RFKDKLGQGGFGSVY 263 ++Y E++ + + +K Y P Y P V++ A+ + ++ +G G FG V Sbjct: 586 AEYTEKLQQYIAPGMKVY--IDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVC 643 Query: 264 KGEL----RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRA 425 +G L R V VA+K L+ E + +F++E + +G H NI+RL G ++ Sbjct: 644 RGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVM 703 Query: 426 LIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIK 605 ++ E+M N +L+ ++ ++ +++ + GIA GM+YL + +H D+ Sbjct: 704 ILTEFMENCALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKYLSE---MNYVHRDLA 755 Query: 606 PHNILL 623 NIL+ Sbjct: 756 ARNILV 761
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.5 bits (145), Expect = 4e-09 Identities = 42/140 (30%), Positives = 73/140 (52%), Gaps = 5/140 (3%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKG-ELRNGVPVAVKMLESSTGEGEEFI----NEVATIGLIHHANI 383 + ++++G GG VYK + VAVK+L+ E EEF+ E + I +ANI Sbjct: 11 KIEEEIGVGGTAVVYKAMDTLLNRHVAVKVLKHEFTEDEEFVFKFKREASAAARIANANI 70 Query: 384 VRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 V + ++G ++ EY+ ++L+K I + + K++D A IA+ + + Sbjct: 71 VNIYDVGADGNVNYIVMEYVAGKTLKKLIKENGK------IEFNKIIDYATQIAKALNFA 124 Query: 564 HQGCNQRILHFDIKPHNILL 623 H+ I+H DIKPHNI++ Sbjct: 125 HK---NGIVHRDIKPHNIMV 141
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 60.5 bits (145), Expect = 4e-09 Identities = 39/134 (29%), Positives = 64/134 (47%) Frame = +3 Query: 222 FKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGF 401 F +LG G FG V G+ R VA+KM+ + +EFI E + + H +V+L G Sbjct: 403 FLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGV 462 Query: 402 CSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQ 581 C++ +I EYM N L Y+ + ++L++ + MEYL ++ Sbjct: 463 CTKQRPIFIITEYMANGCLLNYL-----REMRHRFQTQQLLEMCKDVCEAMEYLE---SK 514 Query: 582 RILHFDIKPHNILL 623 + LH D+ N L+ Sbjct: 515 QFLHRDLAARNCLV 528
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 60.1 bits (144), Expect = 5e-09 Identities = 42/140 (30%), Positives = 72/140 (51%), Gaps = 10/140 (7%) Frame = +3 Query: 234 LGQGGFGSVYKGE---LRNGVP---VAVKMLESSTGEGE-EFINEVATIGLIHHANIVRL 392 LG+ FG V+ + L GV V VK L+S + + +F E+ G ++HAN+VRL Sbjct: 802 LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRL 861 Query: 393 MGFCSEGTRRALIYEYMPNESLEKYI---FSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 +G C E ++ EY+ E L++++ S + + L+ + + + +A GME+L Sbjct: 862 LGLCREAEPHYMVLEYVDLEDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHL 921 Query: 564 HQGCNQRILHFDIKPHNILL 623 N R +H D+ N L+ Sbjct: 922 ---SNNRFVHKDLAARNCLV 938
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 60.1 bits (144), Expect = 5e-09 Identities = 48/159 (30%), Positives = 79/159 (49%), Gaps = 16/159 (10%) Frame = +3 Query: 195 PEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VAVKMLESSTGEGE--EFI 341 P+ ++AR +LGQG FG VY+G + V VA+K + + E EF+ Sbjct: 990 PDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL 1049 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQK---LLAP 512 NE + + + ++VRL+G S+G +I E M L+ Y+ S + Q L+ P Sbjct: 1050 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLVLIPP 1109 Query: 513 --TKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +KM+ +A IA GM YL+ + +H D+ N ++ Sbjct: 1110 SLSKMIQMAGEIADGMAYLNA---NKFVHRDLAARNCMV 1145
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 60.1 bits (144), Expect = 5e-09 Identities = 42/142 (29%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 259 EIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 318 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ + + L +++D+A IA GM Sbjct: 319 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGEMG----RYLRLPQLVDMAAQIASGMA 373 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 374 YVER---MNYVHRDLRAANILV 392
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 60.1 bits (144), Expect = 5e-09 Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 19/182 (10%) Frame = +3 Query: 135 KKVEM-FLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELR-----NGVPVA 296 + VEM L AY + E+ A RF ++LG+ FG +YKG L + VA Sbjct: 449 QNVEMSMLNAYKPKSKAK----ELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVA 504 Query: 297 VKMLE--SSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 470 +K L+ ++ + EF E + + +HH NIV L+G ++ +++EYM L +++ Sbjct: 505 IKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFL 564 Query: 471 F-----------SHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNI 617 S + L L IA+ IA GMEYL + +H D+ NI Sbjct: 565 IMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYL---SSHFFVHKDLAARNI 621 Query: 618 LL 623 L+ Sbjct: 622 LI 623
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 59.7 bits (143), Expect = 7e-09 Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGE---LRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 DKLG+G + +V+KG + N V + LE G I EV+ + + HANIV L Sbjct: 146 DKLGEGTYATVFKGRSKLMENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHD 205 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 L++EY+ ++ L++Y+ H N L++ + + RG+ Y H + Sbjct: 206 LIHTDRSLTLVFEYLDSD-LKQYL-DHCGN----LMSMHNVKIFMFQLLRGLAYCH---H 256 Query: 579 QRILHFDIKPHNILL 623 ++ILH D+KP N+L+ Sbjct: 257 RKILHRDLKPQNLLI 271
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 59.7 bits (143), Expect = 7e-09 Identities = 47/140 (33%), Positives = 67/140 (47%), Gaps = 10/140 (7%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVP-------VAVKMLESSTGEGEE--FINEVATIGLIHHANIV 386 LG G FG VY+G++ +G+P VAVK L E +E F+ E I +H NIV Sbjct: 1122 LGHGAFGEVYEGQV-SGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIV 1180 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQ-KLLAPTKMLDIALGIARGMEYL 563 R +G + R ++ E M L+ ++ SQ LA +L +A IA G +YL Sbjct: 1181 RCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYL 1240 Query: 564 HQGCNQRILHFDIKPHNILL 623 + +H DI N LL Sbjct: 1241 EE---NHFIHRDIAARNCLL 1257
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 59.7 bits (143), Expect = 7e-09 Identities = 40/136 (29%), Positives = 69/136 (50%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G FG V G L+ + VA+K L+ E + +F+ E + +G H NI+RL Sbjct: 628 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 687 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ ++ EYM N SL+ ++ H + + +++ + GIA GM+YL Sbjct: 688 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---S 739 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ NIL+ Sbjct: 740 DMGYVHRDLAARNILI 755
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 59.7 bits (143), Expect = 7e-09 Identities = 42/142 (29%), Positives = 69/142 (48%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 268 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 327 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ K L +++D++ IA GM Sbjct: 328 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKGETG----KYLRLPQLVDMSAQIASGMA 382 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 383 YVER---MNYVHRDLRAANILV 401
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 59.7 bits (143), Expect = 7e-09 Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 2/132 (1%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCS 407 LG+G FG VYKG L++ PVAVK + + +F+ E + H NIV+L+G C+ Sbjct: 70 LGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 129 Query: 408 EGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 587 + +I E +P ++ + K +++ +L +A GM YL + Sbjct: 130 QRQPVYIIMELVPGGDFLSFLRKRKDELKLK-----QLVRFSLDVAAGMLYLE---GKNC 181 Query: 588 LHFDIKPHNILL 623 +H D+ N L+ Sbjct: 182 IHRDLAARNCLV 193
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 59.7 bits (143), Expect = 7e-09 Identities = 40/136 (29%), Positives = 69/136 (50%), Gaps = 6/136 (4%) Frame = +3 Query: 234 LGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLM 395 +G G FG V G L+ + VA+K L+ E + +F+ E + +G H NI+RL Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 G ++ ++ EYM N SL+ ++ H + + +++ + GIA GM+YL Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---S 738 Query: 576 NQRILHFDIKPHNILL 623 + +H D+ NIL+ Sbjct: 739 DMGYVHRDLAARNILI 754
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 59.7 bits (143), Expect = 7e-09 Identities = 48/187 (25%), Positives = 91/187 (48%), Gaps = 15/187 (8%) Frame = +3 Query: 108 KSKYNEEINKKVEMFLKAYGTSKPTRYTFPE--VKKIAR-------RFKDKLGQGGFGSV 260 +S+Y E++ + + +K Y P Y P V+ A+ + ++ +G G FG V Sbjct: 566 ESEYTEKLQQYMVPGMKLY--IDPFTYEDPNEAVRDFAKEIDISCVKIEEVIGAGEFGEV 623 Query: 261 YKGELRNGVP----VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRR 422 +G+L+ VA+K L++ E + +F+ E + +G H NI+RL G + Sbjct: 624 CRGKLKQAGRREQFVAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLEGVVTRSRPV 683 Query: 423 ALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDI 602 ++ E+M N +L+ ++ ++ +++ I GIA GM+YL + +H D+ Sbjct: 684 MILTEFMENGALDSFL-----RMNDGQFTVIQLVGILRGIASGMKYLSE---MNYVHRDL 735 Query: 603 KPHNILL 623 NIL+ Sbjct: 736 AARNILV 742
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 59.7 bits (143), Expect = 7e-09 Identities = 50/181 (27%), Positives = 83/181 (45%), Gaps = 32/181 (17%) Frame = +3 Query: 177 PTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRN---------------GVP--VAVKM 305 P R FP + RFK+KLG+G FG V+ E+ + G P VAVK+ Sbjct: 597 PPRVDFPRSRL---RFKEKLGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKI 653 Query: 306 L--ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSH 479 L +++ +F+ EV + + NI+RL+G C + +I +YM N L +++ +H Sbjct: 654 LRPDATKNARNDFLKEVKIMSRLKDLNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH 713 Query: 480 --VSNISQKL-----------LAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 620 + ++Q L ++ +L + IA GM YL +H D+ N L Sbjct: 714 QLENKVTQGLPGDRESDQGPTISYPMLLHVGAQIASGMRYL---ATLNFVHRDLATRNCL 770 Query: 621 L 623 + Sbjct: 771 V 771
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 59.3 bits (142), Expect = 9e-09 Identities = 47/159 (29%), Positives = 71/159 (44%), Gaps = 6/159 (3%) Frame = +3 Query: 165 GTSKPTRYTF--PEVKKIAR----RFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGE 326 G +P+ Y V +AR +K+G G F VYK R V V + Sbjct: 34 GRGRPSSYRVLRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN 93 Query: 327 GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL 506 + EV + + H NI+R MG C + + EYM +LE+ + S + L Sbjct: 94 RGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSS-----PEPLS 148 Query: 507 APTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 P + L +AL IARG+ YLH ++ + H D+ N L+ Sbjct: 149 WPVR-LHLALDIARGLRYLH---SKGVFHRDLTSKNCLV 183
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 59.3 bits (142), Expect = 9e-09 Identities = 46/158 (29%), Positives = 78/158 (49%), Gaps = 15/158 (9%) Frame = +3 Query: 195 PEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VAVKMLESSTGEGE--EFI 341 P+ ++AR +LGQG FG VY+G + V VA+K + + E EF+ Sbjct: 990 PDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL 1049 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLL----A 509 NE + + + ++VRL+G S+G +I E M L+ Y+ S + L+ + Sbjct: 1050 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPS 1109 Query: 510 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +KM+ +A IA GM YL+ + +H D+ N ++ Sbjct: 1110 LSKMIQMAGEIADGMAYLNA---NKFVHRDLAARNCMV 1144
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 59.3 bits (142), Expect = 9e-09 Identities = 41/136 (30%), Positives = 74/136 (54%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG + G VA+K + + G I E++ + +HH NIV L Sbjct: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPNIVCLQ 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + R LI+E++ + L+KY+ + S + L +++ I +G+ + H Sbjct: 68 DVLMQDARLYLIFEFL-SMDLKKYLDTIPSG---QYLDRSRVKSYLYQILQGIVFCH--- 120 Query: 576 NQRILHFDIKPHNILL 623 ++R+LH D+KP N+L+ Sbjct: 121 SRRVLHRDLKPQNLLI 136
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 59.3 bits (142), Expect = 9e-09 Identities = 42/142 (29%), Positives = 69/142 (48%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 263 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 322 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EYM SL ++ K L +++D++ IA GM Sbjct: 323 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKGETG----KYLRLPQLVDMSAQIASGMA 377 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 378 YVDR---MNYVHRDLRAANILV 396
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 59.3 bits (142), Expect = 9e-09 Identities = 48/158 (30%), Positives = 80/158 (50%), Gaps = 15/158 (9%) Frame = +3 Query: 195 PEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VAVKMLESSTGEGE--EFI 341 P+ ++AR +LGQG FG VY+G + V VA+K + + E EF+ Sbjct: 262 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL 321 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNI-SQKLLAP-- 512 NE + + + ++VRL+G S+G +I E M L+ Y+ S + + +LAP Sbjct: 322 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 381 Query: 513 -TKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +KM+ +A IA GM YL+ + +H D+ N ++ Sbjct: 382 LSKMIQMAGEIADGMAYLNA---NKFVHRDLAARNCMV 416
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 59.3 bits (142), Expect = 9e-09 Identities = 40/147 (27%), Positives = 74/147 (50%), Gaps = 17/147 (11%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFC 404 LG+G FG V E+ N + VAVKM++ + + + E+ + +I H NI+ L+G C Sbjct: 422 LGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCC 480 Query: 405 SEGTRRALIYEYMPNESLEKYIFSH--------------VSNISQKLLAPTKMLDIALGI 542 S+ +I EY P+ +L+ +++ + + ++ ++ A I Sbjct: 481 SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQI 540 Query: 543 ARGMEYLHQGCNQRILHFDIKPHNILL 623 ARGM+YL ++R +H D+ N+L+ Sbjct: 541 ARGMDYL---ASRRCIHRDLAARNVLV 564
>CAD96_DROME (Q9VBW3) Tyrosine kinase receptor Cad96Ca precursor (EC 2.7.10.1)| (Cadherin 96Ca) (Tyrosine kinase receptor HD-14) Length = 773 Score = 59.3 bits (142), Expect = 9e-09 Identities = 50/169 (29%), Positives = 84/169 (49%), Gaps = 16/169 (9%) Frame = +3 Query: 165 GTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELRN-----GVP-VAVKMLESSTGE 326 G + R+ FP + +F + LG+G FG V++ E N G+ VAVK L+ S E Sbjct: 456 GEANCDRWEFPRYRL---KFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATE 512 Query: 327 GE--EFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS-----HV 482 + + ++E+ + L H N+V L+G C++ +I EY+ L+ Y+ S H Sbjct: 513 VDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHY 572 Query: 483 SNISQK--LLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 N K +L + +A+GM+YL ++ I+H D+ NIL+ Sbjct: 573 GNTHGKSNVLTSCDLTSFMYQVAKGMDYL---TSRGIIHRDLAARNILI 618
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 59.3 bits (142), Expect = 9e-09 Identities = 49/189 (25%), Positives = 91/189 (48%), Gaps = 15/189 (7%) Frame = +3 Query: 102 SLKSKYNEEINKKVEMFLKAYGTSKPTRYTFPE--VKKIAR-------RFKDKLGQGGFG 254 S +Y E++ + V +K Y P Y P V++ A+ + ++ +G G FG Sbjct: 578 STDPEYTEKLQQYVTPGMKVY--IDPFTYEDPNEAVREFAKEIDISCVKIEEVIGAGEFG 635 Query: 255 SVYKGEL----RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGT 416 V +G L R + VA+K L+ E + +F++E + +G H NI+ L G ++ Sbjct: 636 EVCRGRLKLPGRREIFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIHLEGVVTKSR 695 Query: 417 RRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHF 596 +I E+M N +L+ ++ ++ +++ + GIA GM+YL + +H Sbjct: 696 PVMIITEFMENCALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKYLSE---MNYVHR 747 Query: 597 DIKPHNILL 623 D+ NIL+ Sbjct: 748 DLAARNILV 756
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 59.3 bits (142), Expect = 9e-09 Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 9/151 (5%) Frame = +3 Query: 198 EVKKIARRFK--DKLGQGGFGSVYKGELRN-GVPVAVKML------ESSTGEGEEFINEV 350 +VK A+R++ D LG+G F +VYK +N VA+K + E+ G + E+ Sbjct: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 Query: 351 ATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDI 530 + + H NI+ L+ + +L++++M + LE I + +L P+ + Sbjct: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDN-----SLVLTPSHIKAY 117 Query: 531 ALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L +G+EYLHQ ILH D+KP+N+LL Sbjct: 118 MLMTLQGLEYLHQ---HWILHRDLKPNNLLL 145
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 59.3 bits (142), Expect = 9e-09 Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 9/151 (5%) Frame = +3 Query: 198 EVKKIARRFK--DKLGQGGFGSVYKGELRN-GVPVAVKML------ESSTGEGEEFINEV 350 +VK A+R++ D LG+G F +VYK +N VA+K + E+ G + E+ Sbjct: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 Query: 351 ATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDI 530 + + H NI+ L+ + +L++++M + LE I + +L P+ + Sbjct: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDN-----SLVLTPSHIKAY 117 Query: 531 ALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 L +G+EYLHQ ILH D+KP+N+LL Sbjct: 118 MLMTLQGLEYLHQ---HWILHRDLKPNNLLL 145
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 59.3 bits (142), Expect = 9e-09 Identities = 40/142 (28%), Positives = 72/142 (50%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R KLG G FG V+ G +N + VA+K L+ T E F+ E + + H Sbjct: 234 EIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANMMKALQHE 293 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +VRL ++ ++ EYM L ++ ++ +L P +++D++ IA GM Sbjct: 294 RLVRLYAVVTK-EPIYIVTEYMARGCLLDFL---KTDEGSRLSLP-RLIDMSAQIAEGMA 348 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 349 YIER---MNSIHRDLRAANILV 367
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 59.3 bits (142), Expect = 9e-09 Identities = 43/142 (30%), Positives = 69/142 (48%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 EV + + ++LG G FG V+ G VAVK L+ + + F+ E + + H Sbjct: 238 EVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHP 297 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +VRL ++ +I EYM N SL ++ S L K+LD+A IA GM Sbjct: 298 RLVRLYAVVTQ-EPIYIITEYMENGSLVDFL----KTPSGIKLNVNKLLDMAAQIAEGMA 352 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 ++ + Q +H D++ NIL+ Sbjct: 353 FIEE---QNYIHRDLRAANILV 371
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 59.3 bits (142), Expect = 9e-09 Identities = 48/158 (30%), Positives = 80/158 (50%), Gaps = 15/158 (9%) Frame = +3 Query: 195 PEVKKIARR---FKDKLGQGGFGSVYKGELRNGVP------VAVKMLESSTGEGE--EFI 341 P+ ++AR +LGQG FG VY+G + V VA+K + + E EF+ Sbjct: 989 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL 1048 Query: 342 NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNI-SQKLLAP-- 512 NE + + + ++VRL+G S+G +I E M L+ Y+ S + + +LAP Sbjct: 1049 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 1108 Query: 513 -TKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 +KM+ +A IA GM YL+ + +H D+ N ++ Sbjct: 1109 LSKMIQMAGEIADGMAYLNA---NKFVHRDLAARNCMV 1143
>INSR_XENLA (Q9PVZ4) Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR)| (XTK-1b) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1362 Score = 58.9 bits (141), Expect = 1e-08 Identities = 46/143 (32%), Positives = 76/143 (53%), Gaps = 12/143 (8%) Frame = +3 Query: 231 KLGQGGFGSVYKG---ELRNGVP---VAVKMLESSTGEGE--EFINEVATIGLIHHANIV 386 +LGQG FG VY+G ++ G P VAVK + S E EF+NE + + + ++V Sbjct: 1017 ELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNEASVMKAFNCHHVV 1076 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQK--LLAPT--KMLDIALGIARGM 554 RL+G S+G +I E M + L+ Y+ S + LAPT +++ +A I+ GM Sbjct: 1077 RLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPTLKEIIQMAAEISDGM 1136 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 YL+ ++ +H D+ N ++ Sbjct: 1137 AYLNA---KKFVHRDLAARNCMV 1156
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 58.9 bits (141), Expect = 1e-08 Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 3/135 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR---NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 DKLG+G + +V+KG + N V + LE G I EV+ + + HANIV L Sbjct: 146 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHD 205 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 L++EY+ ++ L++Y+ H N L++ + + RG+ Y H + Sbjct: 206 LIHTDRSLTLVFEYLDSD-LKQYL-DHCGN----LMSMHNVKIFMFQLLRGLAYCH---H 256 Query: 579 QRILHFDIKPHNILL 623 ++ILH D+KP N+L+ Sbjct: 257 RKILHRDLKPQNLLI 271
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 58.9 bits (141), Expect = 1e-08 Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 19/182 (10%) Frame = +3 Query: 135 KKVEM-FLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKGELR-----NGVPVA 296 + VEM L AY + E+ A RF ++LG+ FG +YKG L + VA Sbjct: 449 QNVEMSMLNAYKPKSKAK----ELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVA 504 Query: 297 VKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 470 +K L+ + EF E + + +HH NIV L+G ++ +++EY+ L +++ Sbjct: 505 IKTLKDYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFL 564 Query: 471 F-----------SHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNI 617 S + L L IA+ IA GMEYL + +H D+ NI Sbjct: 565 IMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYL---SSHFFVHKDLAARNI 621 Query: 618 LL 623 L+ Sbjct: 622 LI 623
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 58.5 bits (140), Expect = 2e-08 Identities = 39/141 (27%), Positives = 72/141 (51%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + + +G G FG V G L+ + VA+K L+S E + +F++E + +G H N Sbjct: 622 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 681 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 ++ L G ++ T +I E+M N SL+ ++ + + +++ + GIA GM+Y Sbjct: 682 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 736 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L + +H D+ NIL+ Sbjct: 737 L---ADMNYVHRDLAARNILV 754
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/140 (32%), Positives = 65/140 (46%), Gaps = 10/140 (7%) Frame = +3 Query: 234 LGQGGFGSVYKGE----LRNGVP---VAVKMLESSTGEGE--EFINEVATIGLIHHANIV 386 LG G FG VY+G L +G VAVK L+ + E EF+ E + H +I+ Sbjct: 1967 LGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHIL 2026 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYI-FSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 +L+G C + LI E M L Y+ + LL T +LDI L I +G YL Sbjct: 2027 KLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVYL 2086 Query: 564 HQGCNQRILHFDIKPHNILL 623 + R +H D+ N L+ Sbjct: 2087 EK---MRFIHRDLAARNCLV 2103
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 58.5 bits (140), Expect = 2e-08 Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 1/146 (0%) Frame = +3 Query: 189 TFPEVKKIARRFKDKLGQGGFGSVYKGE-LRNGVPVAVKMLESSTGEGEEFINEVATIGL 365 +F ++K +F + G G FGSVY+ + + VAVK L E E + + Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAE-------ILSV 59 Query: 366 IHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIA 545 + H NI++ G E ++ EY SL YI S+ S + + ++ A +A Sbjct: 60 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS----EEMDMDHIMTWATDVA 115 Query: 546 RGMEYLHQGCNQRILHFDIKPHNILL 623 +GM YLH +++H D+K N+++ Sbjct: 116 KGMHYLHMEAPVKVIHRDLKSRNVVI 141
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 58.5 bits (140), Expect = 2e-08 Identities = 39/141 (27%), Positives = 72/141 (51%), Gaps = 6/141 (4%) Frame = +3 Query: 219 RFKDKLGQGGFGSVYKGELR----NGVPVAVKMLESSTGEGE--EFINEVATIGLIHHAN 380 + + +G G FG V G L+ + VA+K L+S E + +F++E + +G H N Sbjct: 630 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 689 Query: 381 IVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEY 560 ++ L G ++ T +I E+M N SL+ ++ + + +++ + GIA GM+Y Sbjct: 690 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT-----VIQLVGMLRGIAAGMKY 744 Query: 561 LHQGCNQRILHFDIKPHNILL 623 L + +H D+ NIL+ Sbjct: 745 L---ADMNYVHRDLAARNILV 762
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/140 (32%), Positives = 67/140 (47%), Gaps = 10/140 (7%) Frame = +3 Query: 234 LGQGGFGSVYKGELRNGVP-------VAVKMLESSTGEGEE--FINEVATIGLIHHANIV 386 LG G FG VY+G++ +G+P VAVK L E +E F+ E I +H NIV Sbjct: 1126 LGHGAFGEVYEGQV-SGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIV 1184 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKL-LAPTKMLDIALGIARGMEYL 563 R +G + R ++ E M L+ ++ +Q LA +L +A IA G +YL Sbjct: 1185 RCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYL 1244 Query: 564 HQGCNQRILHFDIKPHNILL 623 + +H DI N LL Sbjct: 1245 EE---NHFIHRDIAARNCLL 1261
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 58.5 bits (140), Expect = 2e-08 Identities = 47/135 (34%), Positives = 65/135 (48%), Gaps = 5/135 (3%) Frame = +3 Query: 234 LGQGGFGSVYKGELR-NGVPVAVKMLESSTGEGE----EFINEVATIGLIHHANIVRLMG 398 LG+G FG VY L+ N VA+K+L S E E + EV + H NI+RL Sbjct: 22 LGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYN 81 Query: 399 FCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCN 578 + + TR LI EY P L K + H Q+ + L AL Y H+ Sbjct: 82 YFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDAL------TYCHE--- 132 Query: 579 QRILHFDIKPHNILL 623 ++++H DIKP N+LL Sbjct: 133 KKVIHRDIKPENLLL 147
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 58.5 bits (140), Expect = 2e-08 Identities = 41/142 (28%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 E+ + + R + KLGQG FG V+ G VA+K L+ T E F+ E + + H Sbjct: 259 EIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 318 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +V+L SE ++ EY+ SL ++ + + L +++D+A IA GM Sbjct: 319 KLVQLYAVVSE-EPIYIVTEYISKGSLLDFLKGEMG----RYLRLPQLVDMAAQIASGMA 373 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 Y+ + +H D++ NIL+ Sbjct: 374 YVER---MNYVHRDLRAANILV 392
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 58.5 bits (140), Expect = 2e-08 Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 1/146 (0%) Frame = +3 Query: 189 TFPEVKKIARRFKDKLGQGGFGSVYKGE-LRNGVPVAVKMLESSTGEGEEFINEVATIGL 365 +F ++K +F + G G FGSVY+ + + VAVK L E E + + Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAE-------ILSV 59 Query: 366 IHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIA 545 + H NI++ G E ++ EY SL YI S+ S + + ++ A +A Sbjct: 60 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS----EEMDMEHIMTWATDVA 115 Query: 546 RGMEYLHQGCNQRILHFDIKPHNILL 623 +GM YLH +++H D+K N+++ Sbjct: 116 KGMHYLHMEAPVKVIHRDLKSRNVVI 141
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 58.5 bits (140), Expect = 2e-08 Identities = 36/136 (26%), Positives = 68/136 (50%), Gaps = 4/136 (2%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRNGVPVA----VKMLESSTGEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G+V+KG R+ + + V++ E G + E+ + + H NIVRL+ Sbjct: 8 EKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLI 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGC 575 + L++E+ ++ L+KY S I + L + RG+ + H Sbjct: 68 DVLHSDKKLTLVFEHC-DQDLKKYFDSLNGEIDMAVCR-----SFMLQLLRGLAFCH--- 118 Query: 576 NQRILHFDIKPHNILL 623 + +LH D+KP N+L+ Sbjct: 119 SHNVLHRDLKPQNLLI 134
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/140 (32%), Positives = 65/140 (46%), Gaps = 10/140 (7%) Frame = +3 Query: 234 LGQGGFGSVYKGE----LRNGVP---VAVKMLESSTGEGE--EFINEVATIGLIHHANIV 386 LG G FG VY+G L +G VAVK L+ + E EF+ E + H +I+ Sbjct: 104 LGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHIL 163 Query: 387 RLMGFCSEGTRRALIYEYMPNESLEKYI-FSHVSNISQKLLAPTKMLDIALGIARGMEYL 563 +L+G C + LI E M L Y+ + LL T +LDI L I +G YL Sbjct: 164 KLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVYL 223 Query: 564 HQGCNQRILHFDIKPHNILL 623 + R +H D+ N L+ Sbjct: 224 EK---MRFIHRDLAARNCLV 240
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 58.5 bits (140), Expect = 2e-08 Identities = 44/137 (32%), Positives = 72/137 (52%), Gaps = 5/137 (3%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR---NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 DKLG+G + +VYKG+ + N V + LE G I EV+ + + HANIV L Sbjct: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 228 Query: 399 FCSEGTRRALIYEYMPNESLEKYI--FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 L++EY+ ++ L++Y+ +V N+ L ++L RG+ Y H+ Sbjct: 229 IIHTEKSLTLVFEYL-DKDLKQYLDDCGNVINMHNVKLFLFQLL-------RGLAYCHR- 279 Query: 573 CNQRILHFDIKPHNILL 623 Q++LH D+KP N+L+ Sbjct: 280 --QKVLHRDLKPQNLLI 294
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 58.5 bits (140), Expect = 2e-08 Identities = 44/137 (32%), Positives = 72/137 (52%), Gaps = 5/137 (3%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR---NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMG 398 DKLG+G + +VYKG+ + N V + LE G I EV+ + + HANIV L Sbjct: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 228 Query: 399 FCSEGTRRALIYEYMPNESLEKYI--FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQG 572 L++EY+ ++ L++Y+ +V N+ L ++L RG+ Y H+ Sbjct: 229 IIHTEKSLTLVFEYL-DKDLKQYLDDCGNVINMHNVKLFLFQLL-------RGLAYCHR- 279 Query: 573 CNQRILHFDIKPHNILL 623 Q++LH D+KP N+L+ Sbjct: 280 --QKVLHRDLKPQNLLI 294
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 58.5 bits (140), Expect = 2e-08 Identities = 43/142 (30%), Positives = 68/142 (47%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 EV + + ++LG G FG V+ G VAVK L+ + + F+ E + + H Sbjct: 238 EVPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHK 297 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +VRL +E +I EYM N SL ++ S L K+LD+A I GM Sbjct: 298 RLVRLYAVVTE-EPIYIITEYMENGSLVDFL----KTPSGIKLTINKLLDMAAQIVEGMA 352 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 +L + + +H D++ NIL+ Sbjct: 353 FLEE---RNYIHRDLRAANILV 371
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/142 (29%), Positives = 70/142 (49%) Frame = +3 Query: 198 EVKKIARRFKDKLGQGGFGSVYKGELRNGVPVAVKMLESSTGEGEEFINEVATIGLIHHA 377 EV + + ++LG G FG V+ G + VAVK L+ + + F+ E + + H Sbjct: 238 EVPRETLKLVERLGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQ 297 Query: 378 NIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGME 557 +VRL ++ +I EYM N SL ++ S L K+LD+A IA GM Sbjct: 298 RLVRLYAVVTQ-EPIYIITEYMENGSLVDFL----KTPSGIKLTINKLLDMAAQIAEGMA 352 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 ++ + + +H D++ NIL+ Sbjct: 353 FIEE---RNYIHRDLRAANILV 371
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 58.2 bits (139), Expect = 2e-08 Identities = 43/143 (30%), Positives = 75/143 (52%), Gaps = 12/143 (8%) Frame = +3 Query: 231 KLGQGGFGSVYKG-ELRNGVPVAVKMLESSTGEGEEFINEVATIGLIH------HANIVR 389 ++G G +G+VYK +L++G VA+K + T E ++ V + L+ H NIV+ Sbjct: 14 EIGVGAYGTVYKARDLQSGKFVALKNVRVQTNENGLPLSTVREVTLLKRLEHFDHPNIVK 73 Query: 390 LMGFCSEG-----TRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGM 554 LM C+ T+ L++E++ ++ L+ Y+ S + L + D+ G+ Sbjct: 74 LMDVCASARTDRETKVTLVFEHV-DQDLKTYL----SKVPPPGLPLETIKDLMKQFLSGL 128 Query: 555 EYLHQGCNQRILHFDIKPHNILL 623 E+LH C I+H D+KP NIL+ Sbjct: 129 EFLHLNC---IVHRDLKPENILV 148
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 58.2 bits (139), Expect = 2e-08 Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 10/173 (5%) Frame = +3 Query: 135 KKVEMFLKAYGTSKPTRYTFPEVKKIARRFKDKLGQGGFGSVYKG-ELRNGVPVAVKML- 308 +K ++F+K + P T I+ R +G+G FG+VY G L +G +AVK + Sbjct: 42 RKSKIFIKPSFSPPPPANTVDMAPPISWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVL 101 Query: 309 --------ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 464 E + +E EV + + H NIVR +G E ++ E++P S+ Sbjct: 102 IAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISS 161 Query: 465 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 623 + + T+ L + G+EYLH N I+H DIK NIL+ Sbjct: 162 LLEKFGPFPESVVRTYTRQLLL------GLEYLH---NHAIMHRDIKGANILV 205
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 58.2 bits (139), Expect = 2e-08 Identities = 43/142 (30%), Positives = 75/142 (52%), Gaps = 10/142 (7%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELRN-GVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG R G VA+K + + G I E++ + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIAL------GIARGME 557 + +R LI+E++ + L+KY+ S + P + +D +L I +G+ Sbjct: 68 DVLMQDSRLYLIFEFL-SMDLKKYLDS---------IPPGQFMDSSLVKSYLYQILQGIV 117 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 + H ++R+LH D+KP N+L+ Sbjct: 118 FCH---SRRVLHRDLKPQNLLI 136
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 58.2 bits (139), Expect = 2e-08 Identities = 43/142 (30%), Positives = 75/142 (52%), Gaps = 10/142 (7%) Frame = +3 Query: 228 DKLGQGGFGSVYKGELR-NGVPVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLM 395 +K+G+G +G VYKG R G VA+K + + G I E++ + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 396 GFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIAL------GIARGME 557 + +R LI+E++ + L+KY+ S + P + +D +L I +G+ Sbjct: 68 DVLMQDSRLYLIFEFL-SMDLKKYLDS---------IPPGQFMDSSLVKSYLHQILQGIV 117 Query: 558 YLHQGCNQRILHFDIKPHNILL 623 + H ++R+LH D+KP N+L+ Sbjct: 118 FCH---SRRVLHRDLKPQNLLI 136 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 87,521,344 Number of Sequences: 219361 Number of extensions: 1786469 Number of successful extensions: 7093 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6014 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6249 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5710231900 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
