>OSBP1_HUMAN (P22059) Oxysterol-binding protein 1|
          Length = 807

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 17/84 (20%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARKMQESG-------------WKPRWFAKDKGSDT--- 158
           +ENG ++ ANAEK RLE++QR +RK +E+              +K  WF + K   T   
Sbjct: 724 MENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKEL 783

Query: 159 -YRYLGGYWESREKSSWEGCPDIF 227
            + Y G YWE +EK  W  CPDIF
Sbjct: 784 THIYRGEYWECKEKQDWSSCPDIF 807

>OSBP1_RABIT (P16258) Oxysterol-binding protein 1|
          Length = 809

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 17/84 (20%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARKMQESG-------------WKPRWFAKDKGSDT--- 158
           +ENG ++ ANAEK RLE++QR +RK +E+              +K  WF + K   T   
Sbjct: 726 MENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKEL 785

Query: 159 -YRYLGGYWESREKSSWEGCPDIF 227
            + Y G YWE +EK  W  CPDIF
Sbjct: 786 THIYRGEYWECKEKQDWNSCPDIF 809

>YB35_SCHPO (O14340) Oxysterol-binding protein homolog C2F12.05c|
          Length = 1310

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 18/85 (21%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARKMQESG----WKPRWFAKDK----GSDTYRYLGGYW 182
            +ENG+Y+ A +EK RLE++QR+ R+M+E G    W PRWF+  K    G D +++   YW
Sbjct: 1226 MENGQYDLAASEKNRLEEKQRKKRRMREQGEMPPWSPRWFSAAKHPVTGEDYWQFNNEYW 1285

Query: 183  ESREKS----------SWEGCPDIF 227
            + RE++           W    DIF
Sbjct: 1286 KIREEAGEAHLAGKEFEWPNVDDIF 1310

>OSBP2_MOUSE (Q5QNQ6) Oxysterol-binding protein 2|
          Length = 908

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 19/86 (22%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARKM---------------QESGWKPRWFAKD----KG 149
            +E G ++ AN EK RLE++QR +R+                +  G+ P WF K      G
Sbjct: 823  MERGRWDEANTEKQRLEEKQRLSRRRRLESCTAGCGGEEEKESDGYVPLWFEKRLDPLTG 882

Query: 150  SDTYRYLGGYWESREKSSWEGCPDIF 227
                 Y GGYWE++EK  W  CP+IF
Sbjct: 883  EMACMYKGGYWEAKEKKDWHMCPNIF 908

>OSH1_YEAST (P35845) Oxysterol-binding protein homolog 1|
          Length = 1188

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 28/74 (37%), Positives = 47/74 (63%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARKMQE---SGWKPRWFAKDKGSDT----YRYLGGYWE 185
            +ENGEY++A AEK R+E +QR A+K +E     ++P+WF +++   T    +++ G YW 
Sbjct: 1115 MENGEYDKAAAEKHRVEVKQRAAKKEREQKGEEYRPKWFVQEEHPVTKSLYWKFNGEYWN 1174

Query: 186  SREKSSWEGCPDIF 227
             R+   ++ C DIF
Sbjct: 1175 KRKNHDFKDCADIF 1188

>OSBP2_HUMAN (Q969R2) Oxysterol-binding protein 2 (Oxysterol-binding|
            protein-related protein 4) (OSBP-related protein 4)
            (ORP-4)
          Length = 916

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 21/88 (23%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARKM-----------------QESGWKPRWFAKD---- 143
            +E G ++ AN EK RLE++QR +R+                  +   + P WF K     
Sbjct: 829  MEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPL 888

Query: 144  KGSDTYRYLGGYWESREKSSWEGCPDIF 227
             G     Y GGYWE++EK  W  CP+IF
Sbjct: 889  TGEMACVYKGGYWEAKEKQDWHMCPNIF 916

>OSH2_YEAST (Q12451) Oxysterol-binding protein homolog 2|
          Length = 1283

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 28/74 (37%), Positives = 41/74 (55%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARKMQESG---WKPRWFAKDKGSDT----YRYLGGYWE 185
            +E+G Y+ A  EK R+E++QR AR+ +E     + P+WF +D    T    +RY G YW 
Sbjct: 1210 MEDGRYDEAGDEKFRVEEKQRAARRKREENNLEYHPQWFVRDTHPITKAKYWRYTGKYWV 1269

Query: 186  SREKSSWEGCPDIF 227
             R     + C DIF
Sbjct: 1270 KRRDHDLKDCGDIF 1283

>YEH1_SCHPO (O13944) Oxysterol-binding protein homolog C23H4.01c|
          Length = 945

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 30/80 (37%), Positives = 38/80 (47%), Gaps = 14/80 (17%)
 Frame = +3

Query: 30   ENGEYERANAEKLRLEQRQRQARKMQESG---WKPRWFAKDKGSDTYRYLGG-------- 176
            EN + + A   KL LEQ+QR+ RK  E     W+PRWF      D     G         
Sbjct: 866  ENNDLDHAEPLKLELEQKQRERRKEMEEKDIKWEPRWFVPSVAGDDEDEDGSGPIWQLKK 925

Query: 177  ---YWESREKSSWEGCPDIF 227
               YWESRE S+W  CP ++
Sbjct: 926  ENNYWESRENSTWSSCPKLW 945

>OSBL1_RAT (Q8K4M9) Oxysterol-binding protein-related protein 1 (OSBP-related|
            protein 1) (ORP-1)
          Length = 950

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 29/74 (39%), Positives = 42/74 (56%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARK---MQESGWKPRWFAKD----KGSDTYRYLGGYWE 185
            +ENGE ++A+ EK RLE++QR ARK     E  WK RWF +      G+  + Y G YW+
Sbjct: 881  MENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWD 940

Query: 186  SREKSSWEGCPDIF 227
                 ++   PDI+
Sbjct: 941  ----RNYFNLPDIY 950

>OSBL1_HUMAN (Q9BXW6) Oxysterol-binding protein-related protein 1 (OSBP-related|
            protein 1) (ORP-1)
          Length = 950

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 29/74 (39%), Positives = 42/74 (56%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARK---MQESGWKPRWFAKD----KGSDTYRYLGGYWE 185
            +ENGE ++A+ EK RLE++QR ARK     E  WK RWF +      G+  + Y G YW+
Sbjct: 881  MENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWD 940

Query: 186  SREKSSWEGCPDIF 227
                 ++   PDI+
Sbjct: 941  ----RNYFNLPDIY 950

>OSBL1_MOUSE (Q91XL9) Oxysterol-binding protein-related protein 1 (OSBP-related|
            protein 1) (ORP-1)
          Length = 950

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 29/74 (39%), Positives = 41/74 (55%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27   LENGEYERANAEKLRLEQRQRQARK---MQESGWKPRWFAKD----KGSDTYRYLGGYWE 185
            +ENGE + A+ EK RLE++QR ARK     E  WK RWF +      G+  + Y G YW+
Sbjct: 881  MENGEIDLASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWD 940

Query: 186  SREKSSWEGCPDIF 227
                 ++   PDI+
Sbjct: 941  ----RNYFNLPDIY 950

>OSBL2_MOUSE (Q8BX94) Oxysterol-binding protein-related protein 2 (OSBP-related|
           protein 2) (ORP-2)
          Length = 484

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARK---MQESGWKPRWFAKDK----GSDTYRYLGGYWE 185
           +ENG  + A+ EK RLE++QR+ARK    +++ W+ RWF+       G+  + Y G Y+E
Sbjct: 415 MENGNMDLASQEKERLEEKQREARKERAKEDAEWRTRWFSPGNNPYTGAPDWLYAGHYFE 474

Query: 186 SREKSSWEGCPDIF 227
                ++  CPDI+
Sbjct: 475 ----RNFSDCPDIY 484

>OSBL2_HUMAN (Q9H1P3) Oxysterol-binding protein-related protein 2 (OSBP-related|
           protein 2) (ORP-2)
          Length = 480

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 7/74 (9%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARK---MQESGWKPRWFAKDK----GSDTYRYLGGYWE 185
           +ENG  + A+ EK RLE++QR+AR+    +E+ W+ RWF        G+  + Y G Y+E
Sbjct: 411 MENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFE 470

Query: 186 SREKSSWEGCPDIF 227
                ++  CPDI+
Sbjct: 471 ----RNFSDCPDIY 480

>OSH3_YEAST (P38713) Oxysterol-binding protein homolog 3|
          Length = 996

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
 Frame = +3

Query: 30   ENGEYERANAEKLRLEQRQRQARKMQESGWKPRWFAKDKGSDTYRYLGG---YWESREKS 200
            E G  ++A   KL+LEQ QR+ R+ +    +P++F K    + ++Y+ G   YWE R+K 
Sbjct: 930  EEGNVDKAEEWKLKLEQLQRE-RRNKGQDVEPKYFEK-VSKNEWKYITGPKSYWERRKKH 987

Query: 201  SW 206
             W
Sbjct: 988  DW 989

>OSBL5_MOUSE (Q9ER64) Oxysterol-binding protein-related protein 5 (OSBP-related|
           protein 5) (ORP-5) (Oxysterol-binding protein homolog 1)
          Length = 874

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
 Frame = +3

Query: 18  TECLENGEYERANAEKLRLEQRQRQ-ARKMQES--GWKPRWFAKDKGSDTYRYLGGYWES 188
           T  +  G+  +A  EK  LE+ QRQ AR+ Q+S   WKP+ F  D  +  +RY       
Sbjct: 654 TRAIREGDQHKATQEKSVLEEAQRQRAREHQQSLTPWKPQLFLLDPLTQEWRY-----RY 708

Query: 189 REKSSWEGCPDI 224
            + S W+   DI
Sbjct: 709 EDLSPWDPLKDI 720

>OSBL3_HUMAN (Q9H4L5) Oxysterol-binding protein-related protein 3 (OSBP-related|
           protein 3) (ORP-3)
          Length = 887

 Score = 34.7 bits (78), Expect = 0.27
 Identities = 22/59 (37%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARKMQESG---WKPRWFAKDKGSDTYRYLGGYWESRE 194
           LE G  E A  +K R+EQ QR+ R++ E      +PR+F K    D++   G Y E R+
Sbjct: 817 LEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRK-SDDDSWVSNGTYLELRK 874

>OSBL3_MOUSE (Q9DBS9) Oxysterol-binding protein-related protein 3 (OSBP-related|
           protein 3) (ORP-3)
          Length = 855

 Score = 34.7 bits (78), Expect = 0.27
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 3/59 (5%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARK-MQESG--WKPRWFAKDKGSDTYRYLGGYWESRE 194
           LE G+ E A  +K R+E+ QR+ R+ ++E+G   +PR+F K    D +   G Y E R+
Sbjct: 785 LEEGDIEEAEVQKQRIEKLQRERRRVLEENGVEHQPRFFRK-SSDDAWVSNGTYLELRK 842

>SFR16_HUMAN (Q8N2M8) Splicing factor, arginine/serine-rich 16 (Suppressor of|
           white-apricot homolog 2)
          Length = 659

 Score = 31.2 bits (69), Expect = 3.0
 Identities = 17/51 (33%), Positives = 32/51 (62%)
 Frame = +3

Query: 48  RANAEKLRLEQRQRQARKMQESGWKPRWFAKDKGSDTYRYLGGYWESREKS 200
           RA A K+R+++R+R+ ++ +E  W+ R +++   S + RY   Y  SR +S
Sbjct: 601 RAMARKIRMKERERREKEREE--WE-RQYSRQSRSPSPRYSREYSSSRRRS 648

>SFR16_MOUSE (Q8CFC7) Splicing factor, arginine/serine-rich 16 (Suppressor of|
           white-apricot homolog 2) (Clk4-associating SR-related
           protein)
          Length = 653

 Score = 31.2 bits (69), Expect = 3.0
 Identities = 17/51 (33%), Positives = 32/51 (62%)
 Frame = +3

Query: 48  RANAEKLRLEQRQRQARKMQESGWKPRWFAKDKGSDTYRYLGGYWESREKS 200
           RA A K+R+++R+R+ ++ +E  W+ R +++   S + RY   Y  SR +S
Sbjct: 595 RAMARKIRMKERERREKEREE--WE-RQYSRQSRSPSPRYSREYSSSRRRS 642

>RECK_MOUSE (Q9Z0J1) Reversion-inducing cysteine-rich protein with Kazal motifs|
           precursor (mRECK)
          Length = 971

 Score = 30.8 bits (68), Expect = 3.9
 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
 Frame = +1

Query: 349 LKCLSACKQKAALSDTLFFRT**ECPFVQKVTLNPMFSCGDFTRTGSECC-YIGH 510
           L+C  ACKQ ++ +D             +K   N +FSC      GS CC Y GH
Sbjct: 111 LECRQACKQASSKNDI--------SKVCRKEYENALFSCISRNEMGSVCCSYAGH 157

>RECK_HUMAN (O95980) Reversion-inducing cysteine-rich protein with Kazal motifs|
           precursor (hRECK) (Suppressor of tumorigenicity 15)
           (ST15)
          Length = 971

 Score = 30.8 bits (68), Expect = 3.9
 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
 Frame = +1

Query: 349 LKCLSACKQKAALSDTLFFRT**ECPFVQKVTLNPMFSCGDFTRTGSECC-YIGH 510
           L+C  ACKQ ++ +D             +K   N +FSC      GS CC Y GH
Sbjct: 111 LECRQACKQASSKNDI--------SKVCRKEYENALFSCISRNEMGSVCCSYAGH 157

>KES1_SCHPO (O74178) Protein kes1|
          Length = 388

 Score = 30.8 bits (68), Expect = 3.9
 Identities = 16/44 (36%), Positives = 27/44 (61%), Gaps = 4/44 (9%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARKMQESG---WKPRWFA-KDK 146
           L+ G+Y  A+ EK ++E+ QR+ R+ +E     W  ++F  KDK
Sbjct: 321 LDAGDYAAASQEKSKIEEGQRELRRQEEEHNEVWHRKYFEWKDK 364

>MTMRD_XENLA (Q6NTN5) Myotubularin-related protein 13 (SET-binding factor 2)|
          Length = 1873

 Score = 30.4 bits (67), Expect = 5.1
 Identities = 15/37 (40%), Positives = 20/37 (54%)
 Frame = +3

Query: 114  GWKPRWFAKDKGSDTYRYLGGYWESREKSSWEGCPDI 224
            GWKPRWF  D      R    Y++S E +S +G  D+
Sbjct: 1783 GWKPRWFVLDITKHQLR----YYDSGEDTSCKGYIDL 1815

>MTMRD_HUMAN (Q86WG5) Myotubularin-related protein 13 (SET-binding factor 2)|
          Length = 1849

 Score = 30.4 bits (67), Expect = 5.1
 Identities = 15/37 (40%), Positives = 20/37 (54%)
 Frame = +3

Query: 114  GWKPRWFAKDKGSDTYRYLGGYWESREKSSWEGCPDI 224
            GWKPRWF  D      R    Y++S E +S +G  D+
Sbjct: 1759 GWKPRWFVLDVTKHQLR----YYDSGEDTSCKGHIDL 1791

>BIRC6_HUMAN (Q9NR09) Baculoviral IAP repeat-containing protein 6|
            (Ubiquitin-conjugating BIR-domain enzyme apollon)
          Length = 4829

 Score = 30.0 bits (66), Expect = 6.6
 Identities = 18/71 (25%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
 Frame = -1

Query: 330  LKMEPTDSKRRTENQKTCNLLEPSQLSLDRLEVVRKCQGSLPSCSFLWIPSNHRG--SGM 157
            +K E T   R++EN + C+LL+   +++ R +     +  +  C+ L     H    + +
Sbjct: 1248 VKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCAMLQFSEFHEKLLNTL 1307

Query: 156  CRYLYPSQTTE 124
            CR     Q TE
Sbjct: 1308 CRKTDDGQITE 1318

>KES1_USTMA (P0C199) Protein KES1|
          Length = 383

 Score = 30.0 bits (66), Expect = 6.6
 Identities = 12/33 (36%), Positives = 21/33 (63%)
 Frame = +3

Query: 27  LENGEYERANAEKLRLEQRQRQARKMQESGWKP 125
           + +G++E A+ +K R+E  QRQ RK + +   P
Sbjct: 312 IRSGDFETASKDKARIENAQRQKRKDEAAAGTP 344


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,796,634
Number of Sequences: 219361
Number of extensions: 1980130
Number of successful extensions: 4934
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 4764
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4917
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6541540170
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)