ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd1i16 |
|---|---|
| Clone Library Name | barley_pub |
>WNK1_MOUSE (P83741) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2377 Score = 131 bits (330), Expect = 7e-31 Identities = 67/141 (47%), Positives = 89/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV- 206 TVY+ D +EVAW +L D + +R E +LK L+H NI++FY SW Sbjct: 234 TVYKGLDTETTVEVAW--CELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV 291 Query: 207 -SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + I +TE+ TSGTL+ Y ++ + + I ++ WCRQIL GL +LH+ PPIIHRDLK Sbjct: 292 KGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLK 351 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDNIF+ G G VKIGDLGLA Sbjct: 352 CDNIFITGPTGSVKIGDLGLA 372
>WNK1_RAT (Q9JIH7) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2126 Score = 131 bits (330), Expect = 7e-31 Identities = 67/141 (47%), Positives = 89/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV- 206 TVY+ D +EVAW +L D + +R E +LK L+H NI++FY SW Sbjct: 234 TVYKGLDTETTVEVAW--CELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV 291 Query: 207 -SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + I +TE+ TSGTL+ Y ++ + + I ++ WCRQIL GL +LH+ PPIIHRDLK Sbjct: 292 KGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLK 351 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDNIF+ G G VKIGDLGLA Sbjct: 352 CDNIFITGPTGSVKIGDLGLA 372
>WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 131 bits (330), Expect = 7e-31 Identities = 67/141 (47%), Positives = 89/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV- 206 TVY+ D +EVAW +L D + +R E +LK L+H NI++FY SW Sbjct: 234 TVYKGLDTETTVEVAW--CELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV 291 Query: 207 -SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + I +TE+ TSGTL+ Y ++ + + I ++ WCRQIL GL +LH+ PPIIHRDLK Sbjct: 292 KGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLK 351 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDNIF+ G G VKIGDLGLA Sbjct: 352 CDNIFITGPTGSVKIGDLGLA 372
>WNK3_HUMAN (Q9BYP7) Serine/threonine-protein kinase WNK3 (EC 2.7.11.1)| (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) Length = 1743 Score = 129 bits (324), Expect = 3e-30 Identities = 66/141 (46%), Positives = 89/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV- 206 TVY+ D +EVAW +L D + +R E +LK L+H NI++FY SW + Sbjct: 160 TVYKGLDTETWVEVAW--CELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL 217 Query: 207 -SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + I +TE+ TSGTL+ Y ++ + + ++ WCRQIL GL +LH+ PPIIHRDLK Sbjct: 218 KGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLK 277 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDNIF+ G G VKIGDLGLA Sbjct: 278 CDNIFITGPTGSVKIGDLGLA 298
>PKPA_PHYBL (Q01577) Serine/threonine-protein kinase pkpA (EC 2.7.11.1)| Length = 613 Score = 128 bits (322), Expect = 6e-30 Identities = 68/139 (48%), Positives = 91/139 (65%), Gaps = 1/139 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY+A D E A N ++ + + + L EI +LK+++H NI+ F+ +W + + Sbjct: 31 VYKAIDR----EEAINDNEITNVKVTRQEFKDLGHEIDILKSVRHPNIITFHDAWYNET- 85 Query: 213 RHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 FITE+ TSGTLR+Y +K + NI VK WCRQIL GL YLH H PPIIHRD+KCD Sbjct: 86 -EFVFITELMTSGTLREYIRKLTPLPNIKIVKRWCRQILKGLAYLHGHEPPIIHRDIKCD 144 Query: 390 NIFVNGNQGEVKIGDLGLA 446 NIF+NG GE+KIGD+G A Sbjct: 145 NIFINGAHGEIKIGDMGTA 163
>WNK2_HUMAN (Q9Y3S1) Serine/threonine-protein kinase WNK2 (EC 2.7.11.1)| (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2) Length = 2297 Score = 128 bits (321), Expect = 7e-30 Identities = 67/141 (47%), Positives = 89/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ D +EVAW +L D + +R E +LK L+H NI++FY W + Sbjct: 208 TVYKGLDTETWVEVAW--CELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA 265 Query: 210 A--RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 R I +TE+ TSGTL+ Y ++ + + ++ WCRQIL GLL+LH+ PPIIHRDLK Sbjct: 266 KGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLK 325 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDNIF+ G G VKIGDLGLA Sbjct: 326 CDNIFITGPTGSVKIGDLGLA 346
>WNK4_RAT (Q7TPK6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 125 bits (315), Expect = 4e-29 Identities = 65/141 (46%), Positives = 90/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVYR D +EVAW +++ + + +R E+ +LK L+H NI++FY SW V Sbjct: 184 TVYRGLDTDTTVEVAWCELQTRKLSRA--ERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL 241 Query: 210 ARH--INFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 I +TE+ TSGTL+ Y ++ R++ ++ W RQIL GL +LHS PPI+HRDLK Sbjct: 242 RGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLK 301 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDN+F+ G G VKIGDLGLA Sbjct: 302 CDNVFITGPSGSVKIGDLGLA 322
>WNK4_MOUSE (Q80UE6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 125 bits (315), Expect = 4e-29 Identities = 65/141 (46%), Positives = 90/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVYR D +EVAW +++ + + +R E+ +LK L+H NI++FY SW V Sbjct: 184 TVYRGLDTDTTVEVAWCELQTRKLSRA--ERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL 241 Query: 210 ARH--INFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 I +TE+ TSGTL+ Y ++ R++ ++ W RQIL GL +LHS PPI+HRDLK Sbjct: 242 RGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLK 301 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDN+F+ G G VKIGDLGLA Sbjct: 302 CDNVFITGPSGSVKIGDLGLA 322
>WNK4_HUMAN (Q96J92) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1243 Score = 125 bits (314), Expect = 5e-29 Identities = 65/141 (46%), Positives = 90/141 (63%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVYR D +EVAW +++ + + +R E+ +LK L+H NI++FY SW V Sbjct: 187 TVYRGLDTDTTVEVAWCELQTRKLSRA--ERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL 244 Query: 210 ARH--INFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 I +TE+ TSGTL+ Y ++ R++ ++ W RQIL GL +LHS PPI+HRDLK Sbjct: 245 RGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLK 304 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 CDN+F+ G G VKIGDLGLA Sbjct: 305 CDNVFITGPTGSVKIGDLGLA 325
>NRBP_MOUSE (Q99J45) Nuclear receptor-binding protein (MLF1 adapter molecule)| (HLS7-interacting protein kinase) Length = 535 Score = 104 bits (260), Expect = 9e-23 Identities = 59/142 (41%), Positives = 83/142 (58%), Gaps = 6/142 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 + Y A D +G+EV WN+V+ + E++ L L+H NI+KF+ W DV Sbjct: 81 SAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADVK 140 Query: 210 AR--HINFITEMFTSGTLRQYRQK----HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + FITE +SG+L+Q+ +K H+ +N A K WC QILS L YLHS +PPIIH Sbjct: 141 ENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIH 200 Query: 372 RDLKCDNIFVNGNQGEVKIGDL 437 +L CD IF+ N G +KIG + Sbjct: 201 GNLTCDTIFIQHN-GLIKIGSV 221
>NRBP_PONPY (Q5RBH9) Nuclear receptor-binding protein| Length = 535 Score = 104 bits (259), Expect = 1e-22 Identities = 58/142 (40%), Positives = 83/142 (58%), Gaps = 6/142 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 + Y A D +G+EV WN+V+ + E++ L L+H NI+KF+ W D+ Sbjct: 81 SAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIK 140 Query: 210 AR--HINFITEMFTSGTLRQYRQK----HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + FITE +SG+L+Q+ +K H+ +N A K WC QILS L YLHS +PPIIH Sbjct: 141 ENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIH 200 Query: 372 RDLKCDNIFVNGNQGEVKIGDL 437 +L CD IF+ N G +KIG + Sbjct: 201 GNLTCDTIFIQHN-GLIKIGSV 221
>NRBP_MACFA (Q4R8X0) Nuclear receptor-binding protein| Length = 535 Score = 104 bits (259), Expect = 1e-22 Identities = 58/142 (40%), Positives = 83/142 (58%), Gaps = 6/142 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 + Y A D +G+EV WN+V+ + E++ L L+H NI+KF+ W D+ Sbjct: 81 SAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIK 140 Query: 210 AR--HINFITEMFTSGTLRQYRQK----HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + FITE +SG+L+Q+ +K H+ +N A K WC QILS L YLHS +PPIIH Sbjct: 141 ENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIH 200 Query: 372 RDLKCDNIFVNGNQGEVKIGDL 437 +L CD IF+ N G +KIG + Sbjct: 201 GNLTCDTIFIQHN-GLIKIGSV 221
>NRBP_HUMAN (Q9UHY1) Nuclear receptor-binding protein| Length = 535 Score = 104 bits (259), Expect = 1e-22 Identities = 58/142 (40%), Positives = 83/142 (58%), Gaps = 6/142 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 + Y A D +G+EV WN+V+ + E++ L L+H NI+KF+ W D+ Sbjct: 81 SAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIK 140 Query: 210 AR--HINFITEMFTSGTLRQYRQK----HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + FITE +SG+L+Q+ +K H+ +N A K WC QILS L YLHS +PPIIH Sbjct: 141 ENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIH 200 Query: 372 RDLKCDNIFVNGNQGEVKIGDL 437 +L CD IF+ N G +KIG + Sbjct: 201 GNLTCDTIFIQHN-GLIKIGSV 221
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 73.9 bits (180), Expect = 2e-13 Identities = 45/137 (32%), Positives = 74/137 (54%), Gaps = 1/137 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLY-DFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY +D G E+A QV+ D + ++ L CEI LLK L+H+ I+++Y D + Sbjct: 376 VYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRA 435 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E G+++ + + + + + RQIL G+ YLHS+ I+HRD+K Sbjct: 436 EKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSN--MIVHRDIKGA 493 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + + G VK+GD G Sbjct: 494 NI-LRDSAGNVKLGDFG 509
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 73.6 bits (179), Expect = 2e-13 Identities = 45/137 (32%), Positives = 74/137 (54%), Gaps = 1/137 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLY-DFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY +D G E+A QV+ D + ++ L CEI LLK L+H+ I+++Y D + Sbjct: 376 VYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRA 435 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E G+++ + + + + + RQIL G+ YLHS+ I+HRD+K Sbjct: 436 EKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSN--MIVHRDIKGA 493 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + + G VK+GD G Sbjct: 494 NI-LRDSAGNVKLGDFG 509
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 72.4 bits (176), Expect = 5e-13 Identities = 45/137 (32%), Positives = 73/137 (53%), Gaps = 1/137 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLY-DFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY +D G E+A QV+ D + ++ L CEI LLK L H+ I+++Y D Sbjct: 370 VYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQ 429 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + ++ E G+++ + + + + + RQIL G+ YLHS+ I+HRD+K Sbjct: 430 EKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSN--MIVHRDIKGA 487 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + + G VK+GD G Sbjct: 488 NI-LRDSTGNVKLGDFG 503
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 72.4 bits (176), Expect = 5e-13 Identities = 49/149 (32%), Positives = 82/149 (55%), Gaps = 6/149 (4%) Frame = +3 Query: 15 RARPXTVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFY 188 R + VYRA G+ VA +V+++D + D R C EI LLK L H N++K+Y Sbjct: 42 RGQFSEVYRAACLLDGVPVALKKVQIFDLM---DAKARADCIKEIDLLKQLNHPNVIKYY 98 Query: 189 TSWVDVSARHINFITEMFTSGTL----RQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHN 356 S+++ +N + E+ +G L + ++++ R + V + Q+ S L ++HS Sbjct: 99 ASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156 Query: 357 PPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++HRD+K N+F+ G VK+GDLGL Sbjct: 157 --VMHRDIKPANVFITAT-GVVKLGDLGL 182
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 72.0 bits (175), Expect = 6e-13 Identities = 49/149 (32%), Positives = 82/149 (55%), Gaps = 6/149 (4%) Frame = +3 Query: 15 RARPXTVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFY 188 R + VYRA G+ VA +V+++D + D R C EI LLK L H N++K+Y Sbjct: 42 RGQFSEVYRASCLLDGVPVALKKVQIFDLM---DAKARADCIKEIDLLKQLNHPNVIKYY 98 Query: 189 TSWVDVSARHINFITEMFTSGTL----RQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHN 356 S+++ +N + E+ +G L + ++++ R + V + Q+ S L ++HS Sbjct: 99 ASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRR 156 Query: 357 PPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++HRD+K N+F+ G VK+GDLGL Sbjct: 157 --VMHRDIKPANVFITAT-GVVKLGDLGL 182
>M3K2_MOUSE (Q61083) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 71.2 bits (173), Expect = 1e-12 Identities = 43/137 (31%), Positives = 74/137 (54%), Gaps = 1/137 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLY-DFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY +D G E+A QV+ + + ++ L CEI LLK L H+ I+++Y D Sbjct: 370 VYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQ 429 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + ++ E+ G+++ + + + + + RQIL G+ YLHS+ I+HRD+K Sbjct: 430 EKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSN--MIVHRDIKGA 487 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + + G +K+GD G Sbjct: 488 NI-LRDSTGNIKLGDFG 503
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 70.5 bits (171), Expect = 2e-12 Identities = 42/118 (35%), Positives = 65/118 (55%), Gaps = 3/118 (2%) Frame = +3 Query: 102 LQCPDDL-ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKH 278 ++C D + E +Y EI LLK+L H NI+K + + D ++ +TE + G L + Sbjct: 102 IECDDKIHEEIYNEISLLKSLDHPNIIKLFDVFED--KKYFYLVTEFYEGGELFEQIINR 159 Query: 279 RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG--EVKIGDLGLA 446 K + + +QILSG+ YLH HN I+HRD+K +NI + +KI D GL+ Sbjct: 160 HKFDECDAANIMKQILSGICYLHKHN--IVHRDIKPENILLENKHSLLNIKIVDFGLS 215
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 70.5 bits (171), Expect = 2e-12 Identities = 42/118 (35%), Positives = 65/118 (55%), Gaps = 3/118 (2%) Frame = +3 Query: 102 LQCPDDL-ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKH 278 ++C D + E +Y EI LLK+L H NI+K + + D ++ +TE + G L + Sbjct: 102 IECDDKIHEEIYNEISLLKSLDHPNIIKLFDVFED--KKYFYLVTEFYEGGELFEQIINR 159 Query: 279 RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG--EVKIGDLGLA 446 K + + +QILSG+ YLH HN I+HRD+K +NI + +KI D GL+ Sbjct: 160 HKFDECDAANIMKQILSGICYLHKHN--IVHRDIKPENILLENKHSLLNIKIVDFGLS 215
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 70.1 bits (170), Expect = 2e-12 Identities = 41/106 (38%), Positives = 63/106 (59%), Gaps = 1/106 (0%) Frame = +3 Query: 129 LYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR-KVNIWAVK 305 L+ EIH+L+ L H+NI+K+ + R I I E +G+L++Y +++ +N+ + Sbjct: 919 LWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRNKAHINLKTLH 978 Query: 306 DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++ QI G+ YL S N IHRDL N+ V N+G VKIGD GL Sbjct: 979 NYSVQICQGMDYLGSRN--YIHRDLAARNVLVE-NEGTVKIGDFGL 1021
>M4K1_HUMAN (Q92918) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) Length = 833 Score = 69.7 bits (169), Expect = 3e-12 Identities = 47/138 (34%), Positives = 76/138 (55%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V++A D+ G VA VK+ + DD+ L EI +LKT +H NI+ ++ S++ + Sbjct: 31 VFKARDKVSGDLVALKMVKM----EPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQK 86 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I E +G+L+ Q ++ + CR++L GL YLHS IHRD+K N Sbjct: 87 LWI--CMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK--IHRDIKGAN 142 Query: 393 IFVNGNQGEVKIGDLGLA 446 I +N + GEV++ D G++ Sbjct: 143 ILIN-DAGEVRLADFGIS 159
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 68.2 bits (165), Expect = 9e-12 Identities = 51/138 (36%), Positives = 71/138 (51%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VYR + G VA +VKL L+ DL + EI LLK L H NI+K+ S+ + Sbjct: 23 VYRGLNIKNGETVAVKKVKLSKMLK--SDLSVIKMEIDLLKNLDHPNIVKYRGSYQTNDS 80 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 + I E +G+LR + K+ V + Q+L GLLYL HN +IHRD+K N Sbjct: 81 --LCIILEYCENGSLRSICKNFGKIPENLVALYTFQVLQGLLYL--HNQGVIHRDIKGAN 136 Query: 393 IFVNGNQGEVKIGDLGLA 446 I G +K+ D G+A Sbjct: 137 ILTT-KDGTIKLADFGVA 153
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 67.8 bits (164), Expect = 1e-11 Identities = 49/145 (33%), Positives = 79/145 (54%), Gaps = 6/145 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G+ VA +VKL P R EI L+K LKH+NI++ Y V + Sbjct: 22 TVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIR---EISLMKELKHENIVRLYD--VIHT 76 Query: 210 ARHINFITEMFTSGTLRQY------RQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + + E F L+++ R+ R + + VK + Q+L G+ + H + I+H Sbjct: 77 ENKLTLVFE-FMDNDLKKFMDSRLDREMPRGLELSLVKYFQWQLLQGVAFCHENR--ILH 133 Query: 372 RDLKCDNIFVNGNQGEVKIGDLGLA 446 RDLK N+ +N N+G++K+GD GLA Sbjct: 134 RDLKPQNLLIN-NKGQLKLGDFGLA 157
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 67.8 bits (164), Expect = 1e-11 Identities = 39/106 (36%), Positives = 62/106 (58%), Gaps = 1/106 (0%) Frame = +3 Query: 129 LYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR-KVNIWAVK 305 L+ EIH+L+ L H+NI+K+ W + R I I E +G+L++Y +++ +++ + Sbjct: 922 LWREIHILRELYHENIVKYKGIWHEEGGRSIKLIMEFLPAGSLKEYLPRNKAHIDLKTLL 981 Query: 306 DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++ QI G+ L S N IHRDL N+ V N+ VKIGD GL Sbjct: 982 NYAVQICQGMDLLASRN--YIHRDLAARNVLVE-NENTVKIGDFGL 1024
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 67.8 bits (164), Expect = 1e-11 Identities = 40/110 (36%), Positives = 60/110 (54%), Gaps = 2/110 (1%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 E +Y EI LLK+L H NI+K + + D ++ +TE + G L + K + Sbjct: 109 EEIYNEISLLKSLDHPNIIKLFDVFED--KKYFYLVTEFYEGGELFEQIINRHKFDECDA 166 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG--EVKIGDLGLA 446 + +QILSG+ YLH HN I+HRD+K +NI + +KI D GL+ Sbjct: 167 ANIMKQILSGICYLHKHN--IVHRDIKPENILLENKNSLLNIKIVDFGLS 214
>M4K1_MOUSE (P70218) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK) Length = 827 Score = 66.6 bits (161), Expect = 3e-11 Identities = 47/138 (34%), Positives = 75/138 (54%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V++A D+ VA VK+ + DD+ L EI +LKT +H NI+ ++ S++ + Sbjct: 31 VFKARDKVSKDLVALKMVKM----EPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQK 86 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I E +G+L+ Q ++ + CR++L GL YLHS IHRD+K N Sbjct: 87 LWI--CMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSEKK--IHRDIKGAN 142 Query: 393 IFVNGNQGEVKIGDLGLA 446 I +N + GEVK+ D G++ Sbjct: 143 ILIN-DCGEVKLADFGIS 159
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 65.9 bits (159), Expect = 4e-11 Identities = 43/110 (39%), Positives = 60/110 (54%), Gaps = 1/110 (0%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR-KVNI 293 D ER EI +LK+L+H NI+K+ R++ I E G+LR Y QKH+ +++ Sbjct: 894 DFER---EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDH 950 Query: 294 WAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 + + QI G+ YL + IHRDL NI V N+ VKIGD GL Sbjct: 951 KKLLQYTSQICKGMEYLGTKR--YIHRDLATRNILVE-NENRVKIGDFGL 997
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 65.9 bits (159), Expect = 4e-11 Identities = 43/110 (39%), Positives = 60/110 (54%), Gaps = 1/110 (0%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR-KVNI 293 D ER EI +LK+L+H NI+K+ R++ I E G+LR Y QKH+ +++ Sbjct: 894 DFER---EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH 950 Query: 294 WAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 + + QI G+ YL + IHRDL NI V N+ VKIGD GL Sbjct: 951 IKLLQYTSQICKGMEYLGTKR--YIHRDLATRNILVE-NENRVKIGDFGL 997
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 65.9 bits (159), Expect = 4e-11 Identities = 46/142 (32%), Positives = 75/142 (52%), Gaps = 3/142 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + G VA ++ L P R EI L+K L H+NI+ Y V + Sbjct: 21 TVYKGRNRTNGQLVALKEINLDSEEGTPSTAIR---EISLMKELDHENIVTLYD--VIHT 75 Query: 210 ARHINFITEMFTSGTLRQYRQKHRK---VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 + + E F L++Y + H +++ VK + Q+L G+++ H + ++HRDL Sbjct: 76 ENKLTLVFE-FMDKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGIMFCHDNR--VLHRDL 132 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ +N N+GE+K+GD GLA Sbjct: 133 KPQNLLIN-NKGELKLGDFGLA 153
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 65.9 bits (159), Expect = 4e-11 Identities = 43/110 (39%), Positives = 60/110 (54%), Gaps = 1/110 (0%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR-KVNI 293 D ER EI +LK+L+H NI+K+ R++ I E G+LR Y QKH+ +++ Sbjct: 894 DFER---EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDH 950 Query: 294 WAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 + + QI G+ YL + IHRDL NI V N+ VKIGD GL Sbjct: 951 KKLLQYTSQICKGMEYLGTKR--YIHRDLATRNILVE-NENRVKIGDFGL 997
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 65.5 bits (158), Expect = 6e-11 Identities = 49/145 (33%), Positives = 76/145 (52%), Gaps = 6/145 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G+ VA +VKL P R EI L+K LKH+NI++ Y V + Sbjct: 20 TVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR---EISLMKELKHENIVRLYD--VIHT 74 Query: 210 ARHINFITEMFTSGTLRQYRQKH------RKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + + E F L++Y R + + VK + Q+L GL + H + I+H Sbjct: 75 ENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK--ILH 131 Query: 372 RDLKCDNIFVNGNQGEVKIGDLGLA 446 RDLK N+ +N +G++K+GD GLA Sbjct: 132 RDLKPQNLLIN-KRGQLKLGDFGLA 155
>WRK19_ARATH (Q9SZ67) Probable WRKY transcription factor 19 (WRKY DNA-binding| protein 19) Length = 1895 Score = 64.7 bits (156), Expect = 1e-10 Identities = 46/126 (36%), Positives = 73/126 (57%), Gaps = 1/126 (0%) Frame = +3 Query: 72 AWNQVKLYDF-LQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTS 248 A+ +V L D Q + ++++ I LL L+H+NI+++ + D S +I E+ T Sbjct: 1652 AFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQHQNIVRYRGTTKDESNLYI--FLELVTQ 1709 Query: 249 GTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKI 428 G+LR+ Q+++ + V + RQIL GL YLH IHR++KC N+ V+ N G VK+ Sbjct: 1710 GSLRKLYQRNQ-LGDSVVSLYTRQILDGLKYLHDKG--FIHRNIKCANVLVDAN-GTVKL 1765 Query: 429 GDLGLA 446 D GLA Sbjct: 1766 ADFGLA 1771
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/141 (31%), Positives = 77/141 (54%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYD--FLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 VYRA + G+EVA +K+ D + ++R+ E+ + LKH ++++ Y + D Sbjct: 26 VYRAESIHTGLEVA---IKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDN 82 Query: 207 SARHINFITEMFTSGTLRQYRQKHRK-VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ + EM +G + +Y + K + + + QI++G+LYLHSH I+HRDL Sbjct: 83 N--YVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHG--ILHRDLT 138 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 NI + N +KI D GLA Sbjct: 139 LSNILLTRNM-NIKIADFGLA 158
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/141 (31%), Positives = 78/141 (55%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYD--FLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 VYRA + G+EVA +K+ D + ++R+ E+ + LKH +I++ Y + D Sbjct: 26 VYRAESIHTGLEVA---IKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFED- 81 Query: 207 SARHINFITEMFTSGTLRQY-RQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ + EM +G + +Y + + + + + + QI++G+LYLHSH I+HRDL Sbjct: 82 -SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG--ILHRDLT 138 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ + N +KI D GLA Sbjct: 139 LSNLLLTRNM-NIKIADFGLA 158
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 64.3 bits (155), Expect = 1e-10 Identities = 47/145 (32%), Positives = 77/145 (53%), Gaps = 6/145 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G+ VA +VKL P R EI L+K LKH NI++ + V + Sbjct: 20 TVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR---EISLMKELKHDNIVRLFD--VIHT 74 Query: 210 ARHINFITEMFTSGTLRQYRQK------HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + + E F L+++ H+ + + VK + Q+L G+ + H + I+H Sbjct: 75 ENKLTLVFE-FMDNDLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHENR--ILH 131 Query: 372 RDLKCDNIFVNGNQGEVKIGDLGLA 446 RDLK N+ +N N+G++K+GD GLA Sbjct: 132 RDLKPQNLLIN-NRGQLKLGDFGLA 155
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 64.3 bits (155), Expect = 1e-10 Identities = 45/142 (31%), Positives = 76/142 (53%), Gaps = 3/142 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + G VA ++ L P R EI L+K L H+NI+ Y V + Sbjct: 21 TVYKGRNRATGALVALKEISLDSEEGTPSTAIR---EISLMKELDHENIVTLYD--VIHT 75 Query: 210 ARHINFITEMFTSGTLRQYRQKHRK---VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 + + E + L++Y + H + +++ VK + Q+L G+++ H + ++HRDL Sbjct: 76 ENKLTLVFE-YMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDNR--VLHRDL 132 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ +N N+GE+K+GD GLA Sbjct: 133 KPQNLLIN-NKGELKLGDFGLA 153
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 63.9 bits (154), Expect = 2e-10 Identities = 46/142 (32%), Positives = 75/142 (52%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDD----LERLYCEIHLLKTLKHKNIMKFYTSWV 200 VY + G +A QV L + D L+ L EI LL+ L H++I+++ S Sbjct: 408 VYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGS-- 465 Query: 201 DVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++++ H+N E G++ + VK++ +Q L GL YLHS I+HRD+ Sbjct: 466 NLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRG--IVHRDI 523 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K NI V+ N+G++KI D G++ Sbjct: 524 KGANILVD-NKGKIKISDFGIS 544
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 63.9 bits (154), Expect = 2e-10 Identities = 40/110 (36%), Positives = 62/110 (56%), Gaps = 2/110 (1%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQY--RQKHRKVN 290 +LE++Y E+ L+K L H NI+K Y V + + +TE +G + Y H N Sbjct: 67 NLEKIYREVQLMKLLNHPNIIKLYQ--VMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN 124 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 K W QILS + Y H+H+ I+HRDLK +N+ ++GN ++K+ D G Sbjct: 125 EARKKFW--QILSAVEYCHNHH--IVHRDLKTENLLLDGNM-DIKLADFG 169
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/105 (36%), Positives = 61/105 (58%), Gaps = 2/105 (1%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDV--SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDW 311 EI LLK LKHKNI++ +DV S + + + E + + + ++++ + + Sbjct: 51 EICLLKELKHKNIVRL----IDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSF 106 Query: 312 CRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L GL + HSHN ++HRDLK N+ +N N GE+K+ D GLA Sbjct: 107 MLQLLRGLAFCHSHN--VLHRDLKPQNLLINKN-GELKLADFGLA 148
>PLK3_MOUSE (Q60806) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) Length = 631 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/112 (36%), Positives = 62/112 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI L + L+H++I++F + D A +I E+ + +L + + Sbjct: 102 PHQREKILNEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLL 159 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 V+ + RQILSGL YLH I+HRDLK N F+ N E+K+GD GLA Sbjct: 160 EPEVRYYLRQILSGLKYLHQRG--ILHRDLKLGNFFITDNM-ELKVGDFGLA 208
>PLK2_CAEEL (Q9N2L7) Serine/threonine-protein kinase plk-2 (EC 2.7.11.21)| (Polo-like kinase 2) Length = 632 Score = 63.2 bits (152), Expect = 3e-10 Identities = 37/108 (34%), Positives = 65/108 (60%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +++ E+ + + L+H+N++K Y + D S +I E+ +L + ++ + V Sbjct: 79 DKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITL--ELCPRRSLMELHKRRKAVTEPEA 136 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QI+ G+LYLH N I+HRDLK N+F+N ++ +VKIGD GLA Sbjct: 137 RYFTYQIVEGVLYLH--NLKIVHRDLKLGNLFLN-DELQVKIGDFGLA 181
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/112 (36%), Positives = 62/112 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI L + L+H++I++F + D A +I E+ + +L + + Sbjct: 70 PHQREKIINEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLL 127 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 V+ + RQILSGL YLH I+HRDLK N F+ N E+K+GD GLA Sbjct: 128 EPEVRYYLRQILSGLKYLHQRG--ILHRDLKLGNFFITDNM-ELKVGDFGLA 176
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 62.8 bits (151), Expect = 4e-10 Identities = 41/112 (36%), Positives = 62/112 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI L + L+H++I++F + D A +I E+ + +L + + Sbjct: 101 PHQREKILNEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLL 158 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 V+ + RQILSGL YLH I+HRDLK N F+ N E+K+GD GLA Sbjct: 159 EPEVRYYLRQILSGLKYLHQRG--ILHRDLKLGNFFITENM-ELKVGDFGLA 207
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 62.4 bits (150), Expect = 5e-10 Identities = 40/130 (30%), Positives = 70/130 (53%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA +K+ D Q P L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 82 GREVA---IKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFE--VIETEKTLYLVME 136 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 ++G + Y H ++ + RQI+S + Y H N I+HRDLK +N+ ++ + Sbjct: 137 YASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN--IVHRDLKAENLLLDA-EA 193 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 194 NIKIADFGFS 203
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 62.4 bits (150), Expect = 5e-10 Identities = 40/130 (30%), Positives = 70/130 (53%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA +K+ D Q P L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 82 GREVA---IKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFE--VIETEKTLYLVME 136 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 ++G + Y H ++ + RQI+S + Y H N I+HRDLK +N+ ++ + Sbjct: 137 YASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN--IVHRDLKAENLLLDA-EA 193 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 194 NIKIADFGFS 203
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 62.4 bits (150), Expect = 5e-10 Identities = 39/112 (34%), Positives = 62/112 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI L + L HK++++FY + D +I + E + ++ + + + Sbjct: 118 PHQREKIDKEIELHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLT 175 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 V+ + RQI+SGL YLH I+HRDLK N F+N E+K+GD GLA Sbjct: 176 EPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFIN-EAMELKVGDFGLA 224
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 62.4 bits (150), Expect = 5e-10 Identities = 39/112 (34%), Positives = 62/112 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI L + L HK++++FY + D +I + E + ++ + + + Sbjct: 118 PHQREKIDKEIELHRLLHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLT 175 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 V+ + RQI+SGL YLH I+HRDLK N F+N E+K+GD GLA Sbjct: 176 EPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFIN-EAMELKVGDFGLA 224
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 62.4 bits (150), Expect = 5e-10 Identities = 39/112 (34%), Positives = 62/112 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI L + L HK++++FY + D +I + E + ++ + + + Sbjct: 121 PHQREKIDKEIELHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLT 178 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 V+ + RQI+SGL YLH I+HRDLK N F+N E+K+GD GLA Sbjct: 179 EPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFIN-EAMELKVGDFGLA 227
>CDR1_SCHPO (P07334) Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein| kinase nim1) Length = 593 Score = 62.0 bits (149), Expect = 6e-10 Identities = 34/103 (33%), Positives = 53/103 (51%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +++ L+H NI++ Y W D +H+ E G L Y +KH ++ + Sbjct: 53 EILMMRLLRHPNILRLYDVWTD--HQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLS 110 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QIL + H H HRDLK +NI + N+ ++KI D G+A Sbjct: 111 QILDAVA--HCHRFRFRHRDLKLENILIKVNEQQIKIADFGMA 151
>POLO_DROME (P52304) Serine/threonine-protein kinase polo (EC 2.7.11.21)| Length = 576 Score = 62.0 bits (149), Expect = 6e-10 Identities = 36/108 (33%), Positives = 64/108 (59%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 E+ EI + ++L H NI+KF+ + D +++I + E+ ++ + ++ + + + Sbjct: 68 EKTAQEITIHRSLNHPNIVKFHNYFED--SQNIYIVLELCKKRSMMELHKRRKSITEFEC 125 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QI+ G+ YLH + IIHRDLK N+F+N + VKIGD GLA Sbjct: 126 RYYIYQIIQGVKYLHDNR--IIHRDLKLGNLFLN-DLLHVKIGDFGLA 170
>NEK6_HUMAN (Q9HC98) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) (Protein kinase SID6-1512) Length = 313 Score = 61.6 bits (148), Expect = 8e-10 Identities = 46/149 (30%), Positives = 79/149 (53%), Gaps = 6/149 (4%) Frame = +3 Query: 15 RARPXTVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFY 188 R + VY+A VA +V++++ + D R C EI LLK L H NI+K+ Sbjct: 53 RGQFSEVYKATCLLDRKTVALKKVQIFEMM---DAKARQDCVKEIGLLKQLNHPNIIKYL 109 Query: 189 TSWVDVSARHINFITEMFTSGTLRQ----YRQKHRKVNIWAVKDWCRQILSGLLYLHSHN 356 S+++ +N + E+ +G L Q ++++ R + V + Q+ S + ++HS Sbjct: 110 DSFIE--DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR 167 Query: 357 PPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++HRD+K N+F+ G VK+GDLGL Sbjct: 168 --VMHRDIKPANVFITAT-GVVKLGDLGL 193
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 61.6 bits (148), Expect = 8e-10 Identities = 39/110 (35%), Positives = 61/110 (55%), Gaps = 2/110 (1%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQY--RQKHRKVN 290 +LE++Y E+ L+K L H NI+K Y V + + +TE +G + Y H N Sbjct: 67 NLEKIYREVQLMKLLNHPNIIKLYQ--VMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN 124 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 K W QILS + Y H+H+ I+HRDLK +N+ ++ N ++K+ D G Sbjct: 125 EARQKFW--QILSAVEYCHNHH--IVHRDLKTENLLLDSNM-DIKLADFG 169
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 61.6 bits (148), Expect = 8e-10 Identities = 49/142 (34%), Positives = 74/142 (52%), Gaps = 3/142 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVYR E+ G VA ++ + D P + E+ +LK +H N++ F WV Sbjct: 494 TVYRG--EFFGT-VAIKKLNVVD--PTPSQMAAFKNEVAVLKKTRHLNVLLFM-GWV--R 545 Query: 210 ARHINFITEMFTSGTLRQY---RQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 I IT+ +L ++ ++ + + A+ D +Q+ G+ YLHS N IIHRDL Sbjct: 546 EPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHSKN--IIHRDL 603 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K +NIF+ + VKIGD GLA Sbjct: 604 KTNNIFLMDDMSTVKIGDFGLA 625
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 61.6 bits (148), Expect = 8e-10 Identities = 39/110 (35%), Positives = 61/110 (55%), Gaps = 2/110 (1%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQY--RQKHRKVN 290 +LE++Y E+ L+K L H +I+K Y V + + +TE +G + Y H N Sbjct: 67 NLEKIYREVQLMKLLNHPHIIKLYQ--VMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN 124 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 K W QILS + Y H H+ I+HRDLK +N+ ++GN ++K+ D G Sbjct: 125 EARKKFW--QILSAVEYCHDHH--IVHRDLKTENLLLDGNM-DIKLADFG 169
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 61.2 bits (147), Expect = 1e-09 Identities = 41/130 (31%), Positives = 69/130 (53%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA VK+ D Q P L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 83 GREVA---VKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE--VIETEKTLYLVME 137 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++G+ Sbjct: 138 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY--IVHRDLKAENLLLDGDM- 194 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 195 NIKIADFGFS 204
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 61.2 bits (147), Expect = 1e-09 Identities = 48/140 (34%), Positives = 74/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 TV++A + VA +V+L D + P R EI LLK LKHKNI++ + V Sbjct: 17 TVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKHKNIVRLHD--VLH 71 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S + + + E + + + ++ VK + Q+L GL + HS N ++HRDLK Sbjct: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRN--VLHRDLKP 129 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N N GE+K+ D GLA Sbjct: 130 QNLLINRN-GELKLADFGLA 148
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 61.2 bits (147), Expect = 1e-09 Identities = 45/141 (31%), Positives = 73/141 (51%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K + + Sbjct: 18 VYKAKNKVTGETVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLHDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHRK--VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F L+++ +++ VK + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLHQDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N QGE+K+ D GLA Sbjct: 130 PQNLLINA-QGEIKLADFGLA 149
>NEK6_RAT (P59895) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/149 (30%), Positives = 79/149 (53%), Gaps = 6/149 (4%) Frame = +3 Query: 15 RARPXTVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFY 188 R + VY+A VA +V++++ + D R C EI LLK L H NI+K+ Sbjct: 53 RGQFSEVYKATCLLDRKTVALKKVQIFEMM---DAKARQDCVKEIGLLKQLNHPNIIKYL 109 Query: 189 TSWVDVSARHINFITEMFTSGTLRQ----YRQKHRKVNIWAVKDWCRQILSGLLYLHSHN 356 S+++ +N + E+ +G L Q ++++ R + V + Q+ S + ++HS Sbjct: 110 DSFIE--DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR 167 Query: 357 PPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++HRD+K N+F+ G VK+GDLGL Sbjct: 168 --VMHRDIKPANVFITAT-GIVKLGDLGL 193
>NEK6_MOUSE (Q9ES70) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/149 (30%), Positives = 79/149 (53%), Gaps = 6/149 (4%) Frame = +3 Query: 15 RARPXTVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFY 188 R + VY+A VA +V++++ + D R C EI LLK L H NI+K+ Sbjct: 53 RGQFSEVYKATCLLDRKTVALKKVQIFEMM---DAKARQDCVKEIGLLKQLNHPNIIKYL 109 Query: 189 TSWVDVSARHINFITEMFTSGTLRQ----YRQKHRKVNIWAVKDWCRQILSGLLYLHSHN 356 S+++ +N + E+ +G L Q ++++ R + V + Q+ S + ++HS Sbjct: 110 DSFIE--DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR 167 Query: 357 PPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 ++HRD+K N+F+ G VK+GDLGL Sbjct: 168 --VMHRDIKPANVFITAT-GIVKLGDLGL 193
>PLK1_XENLA (P70032) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Plx1) Length = 598 Score = 60.8 bits (146), Expect = 1e-09 Identities = 38/132 (28%), Positives = 73/132 (55%) Frame = +3 Query: 51 EYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFI 230 + + EV ++ L P +++ EI + ++L H++++ F+ + D ++ + Sbjct: 63 DLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYV--V 120 Query: 231 TEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGN 410 E+ +L + ++ + V + + +Q +SG YLHS+ +IHRDLK N+F+N + Sbjct: 121 LELCRRRSLLELHKRRKAVTEPEARYYLKQTISGCQYLHSNR--VIHRDLKLGNLFLN-D 177 Query: 411 QGEVKIGDLGLA 446 + EVKIGD GLA Sbjct: 178 EMEVKIGDFGLA 189
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 60.8 bits (146), Expect = 1e-09 Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 6/145 (4%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G+ VA +VKL P R EI L+K LKH NI++ Y V + Sbjct: 19 TVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIR---EISLMKELKHDNIVRLYD--VIHT 73 Query: 210 ARHINFITEMFTSGTLRQYRQKH------RKVNIWAVKDWCRQILSGLLYLHSHNPPIIH 371 + + E + L++Y R + + VK + Q+L GL + H + I+H Sbjct: 74 ENKLTLVFE-YMDNDLKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHENK--ILH 130 Query: 372 RDLKCDNIFVNGNQGEVKIGDLGLA 446 RDLK N+ + +G++K+GD GLA Sbjct: 131 RDLKPQNLLIT-KRGQLKLGDFGLA 154
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 1e-09 Identities = 40/119 (33%), Positives = 64/119 (53%), Gaps = 2/119 (1%) Frame = +3 Query: 96 DFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQ 272 + ++ ++ +R + E+ +++ L+H N++KF V + +NFITE GTLR + Sbjct: 369 ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG--VLYKDKRLNFITEYIKGGTLRGIIK 426 Query: 273 KHRKVNIWAVK-DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W+ + + + I SG+ YLHS N IIHRDL N V N+ V + D GLA Sbjct: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMN--IIHRDLNSHNCLVRENR-NVVVADFGLA 482
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 60.8 bits (146), Expect = 1e-09 Identities = 40/119 (33%), Positives = 64/119 (53%), Gaps = 2/119 (1%) Frame = +3 Query: 96 DFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQ 272 + ++ ++ +R + E+ +++ L+H N++KF V + +NFITE GTLR + Sbjct: 369 ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG--VLYKDKRLNFITEYIKGGTLRGIIK 426 Query: 273 KHRKVNIWAVK-DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W+ + + + I SG+ YLHS N IIHRDL N V N+ V + D GLA Sbjct: 427 NMDSQYPWSQRVSFAKDIASGMAYLHSMN--IIHRDLNSHNCLVRENR-NVVVADFGLA 482
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 1e-09 Identities = 40/119 (33%), Positives = 64/119 (53%), Gaps = 2/119 (1%) Frame = +3 Query: 96 DFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQ 272 + ++ ++ +R + E+ +++ L+H N++KF V + +NFITE GTLR + Sbjct: 369 ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG--VLYKDKRLNFITEYIKGGTLRGIIK 426 Query: 273 KHRKVNIWAVK-DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W+ + + + I SG+ YLHS N IIHRDL N V N+ V + D GLA Sbjct: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMN--IIHRDLNSHNCLVRENK-NVVVADFGLA 482
>TSSK4_HUMAN (Q6SA08) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E) Length = 328 Score = 60.5 bits (145), Expect = 2e-09 Identities = 45/141 (31%), Positives = 72/141 (51%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFYTSWVD 203 +VY AF Q + VA VK+ + DD + EI ++K L+HK ++ FY + Sbjct: 38 SVYEAFYTKQKVMVA---VKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIES 94 Query: 204 VSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 S +I I E+ G + ++ Q++ + W Q+ G+ YLHS + I+HRDLK Sbjct: 95 TSRVYI--ILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKS--IVHRDLK 150 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 +N+ ++ VKI D G A Sbjct: 151 LENLLLD-KWENVKISDFGFA 170
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 60.1 bits (144), Expect = 2e-09 Identities = 41/138 (29%), Positives = 72/138 (52%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V RA + + G VA ++ D ++ D+ + EI ++ +L H +I+ Y V + Sbjct: 69 VKRATERFSGRVVAIKSIRK-DKIKDEQDMVHIRREIEIMSSLNHPHIISIYE--VFENK 125 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I I E + G L Y + R+++ + + RQI+S + Y H + ++HRDLK +N Sbjct: 126 DKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNG--VVHRDLKLEN 183 Query: 393 IFVNGNQGEVKIGDLGLA 446 I ++ N +KI D GL+ Sbjct: 184 ILLDDN-CNIKIADFGLS 200
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/140 (34%), Positives = 74/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 TV++A + VA +V+L D + P R EI LLK LKHKNI++ + V Sbjct: 17 TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKHKNIVRLHD--VLH 71 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S + + + E + + + ++ VK + Q+L GL + HS N ++HRDLK Sbjct: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--VLHRDLKP 129 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N N GE+K+ D GLA Sbjct: 130 QNLLINRN-GELKLADFGLA 148
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/140 (34%), Positives = 74/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 TV++A + VA +V+L D + P R EI LLK LKHKNI++ + V Sbjct: 17 TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKHKNIVRLHD--VLH 71 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S + + + E + + + ++ VK + Q+L GL + HS N ++HRDLK Sbjct: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--VLHRDLKP 129 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N N GE+K+ D GLA Sbjct: 130 QNLLINRN-GELKLADFGLA 148
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/140 (34%), Positives = 74/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 TV++A + VA +V+L D + P R EI LLK LKHKNI++ + V Sbjct: 17 TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKHKNIVRLHD--VLH 71 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S + + + E + + + ++ VK + Q+L GL + HS N ++HRDLK Sbjct: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--VLHRDLKP 129 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N N GE+K+ D GLA Sbjct: 130 QNLLINRN-GELKLADFGLA 148
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 60.1 bits (144), Expect = 2e-09 Identities = 36/108 (33%), Positives = 62/108 (57%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 ++L EI + K++ H NI++F + D S ++ + E+ +G+L + ++ + + V Sbjct: 124 KKLLSEIQIHKSMSHPNIVQFIDCFEDDS--NVYILLEICPNGSLMELLKRRKVLTEPEV 181 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QI + Y+HS +IHRDLK NIF + N +KIGD GLA Sbjct: 182 RFFTTQICGAIKYMHSRR--VIHRDLKLGNIFFDSNY-NLKIGDFGLA 226
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 60.1 bits (144), Expect = 2e-09 Identities = 43/141 (30%), Positives = 74/141 (52%), Gaps = 2/141 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFYTSWVD 203 TVY A+ Q + VA VK+ + +D + EI ++K L+HK ++ FY + ++ Sbjct: 38 TVYEAYYTKQKVMVA---VKIISKKKASEDYLNKFLPREIQVMKVLRHKYLINFYQA-IE 93 Query: 204 VSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 ++R + I E+ G + ++ Q++ W Q+ G+ YLHS I+HRDLK Sbjct: 94 TTSR-VYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKG--IVHRDLK 150 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 +N+ ++ + VKI D G A Sbjct: 151 LENLLLDKRE-NVKISDFGFA 170
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 59.7 bits (143), Expect = 3e-09 Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 3/106 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKV---NIWAVKD 308 E ++ L+H N+++ Y V R I +TE G+L Y ++H K N+ + D Sbjct: 569 EAKVMTKLQHPNLVQLYG--VCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLD 626 Query: 309 WCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 C Q+ G+ YL HN IHRDL N V G++ VK+ D GLA Sbjct: 627 MCIQVSKGMTYLERHN--YIHRDLAARNCLV-GSENVVKVADFGLA 669
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 59.7 bits (143), Expect = 3e-09 Identities = 42/114 (36%), Positives = 65/114 (57%), Gaps = 4/114 (3%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTL-RQYRQKHRKVNI 293 D E L E+ LLK L H NIMK Y + D + ++ +++++T G L + + R I Sbjct: 110 DKESLLREVELLKMLDHINIMKLYEFFEDNNYYYL--VSDVYTGGELFDEIISRKRFYEI 167 Query: 294 WAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGE---VKIGDLGLA 446 A + +QILSG+ Y+H +N ++HRDLK +NI + E +KI D GL+ Sbjct: 168 DAAR-IIKQILSGITYMHKNN--VVHRDLKPENILLETKNKEDMIIKIIDFGLS 218
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 59.7 bits (143), Expect = 3e-09 Identities = 39/119 (32%), Positives = 64/119 (53%), Gaps = 2/119 (1%) Frame = +3 Query: 96 DFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQ 272 + ++ ++ +R + E+ +++ L+H N++KF V + +NFITE GTLR + Sbjct: 376 ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG--VLYKEKRLNFITEYIKGGTLRGLIK 433 Query: 273 KHRKVNIWAVK-DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W+ + + + I +G+ YLHS N IIHRDL N V N+ V + D GLA Sbjct: 434 SMDSHYPWSQRVSFAKDIAAGMAYLHSMN--IIHRDLNSHNCLVRENK-SVVVADFGLA 489
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 59.7 bits (143), Expect = 3e-09 Identities = 35/108 (32%), Positives = 58/108 (53%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIW 296 +LE++Y E+ ++K L H +I+K Y S ++ +TE +G + Y H ++N Sbjct: 60 NLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYL--VTEYAKNGEIFDYLANHGRLNES 117 Query: 297 AVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + QILS + Y H I+HRDLK +N+ ++ N +KI D G Sbjct: 118 EARRKFWQILSAVDYCHGRK--IVHRDLKAENLLLDNNM-NIKIADFG 162
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 59.7 bits (143), Expect = 3e-09 Identities = 40/130 (30%), Positives = 68/130 (52%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA +K+ D Q P L++L+ E+ ++K L H NI+K + V + + + I E Sbjct: 79 GREVA---IKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE--VIETEKTLYLIME 133 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++ + Sbjct: 134 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKR--IVHRDLKAENLLLDADM- 190 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 191 NIKIADFGFS 200
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 59.3 bits (142), Expect = 4e-09 Identities = 34/108 (31%), Positives = 58/108 (53%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIW 296 +LE++Y E+ ++K L H +I+K Y S ++ +TE +G + Y H ++N Sbjct: 60 NLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYL--VTEYAKNGEIFDYLANHGRLNES 117 Query: 297 AVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + QILS + Y H ++HRDLK +N+ ++ N +KI D G Sbjct: 118 EARRKFWQILSAVDYCHGRK--VVHRDLKAENLLLDNNM-NIKIADFG 162
>CD2L7_CAEEL (P46551) Putative cell division cycle 2-related protein kinase 7| (EC 2.7.11.22) Length = 730 Score = 59.3 bits (142), Expect = 4e-09 Identities = 50/148 (33%), Positives = 73/148 (49%), Gaps = 10/148 (6%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVD-- 203 VY+A + G +VA +V+L + + P R EI +L+ L HKNI++ +D Sbjct: 325 VYKAVNNLTGEQVALKRVRLENEKEGFPITAIR---EIKILRQLHHKNIVRLMDIVIDDI 381 Query: 204 ----VSARHINF--ITEMFTSGTLRQYRQKHR-KVNIWAVKDWCRQILSGLLYLHSHNPP 362 + NF + E + K N + +Q+L GL Y+H N Sbjct: 382 SMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIH--NTG 439 Query: 363 IIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +HRD+KC NI VN N+GE+KI DLGLA Sbjct: 440 FLHRDIKCSNILVN-NKGELKIADLGLA 466
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/106 (36%), Positives = 57/106 (53%), Gaps = 3/106 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQ---KHRKVNIWAVKD 308 EI LLK LK NI++ Y + S H ++ F L++Y + K + + VK Sbjct: 58 EISLLKELKDDNIVRLYD--IVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKK 115 Query: 309 WCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + Q+ G+ Y HSH I+HRDLK N+ +N G +K+GD GLA Sbjct: 116 FMMQLCKGIAYCHSHR--ILHRDLKPQNLLIN-KDGNLKLGDFGLA 158
>PLK3_CAEEL (Q20845) Serine/threonine-protein kinase plk-3 (EC 2.7.11.21)| (Polo-like kinase 3) Length = 615 Score = 59.3 bits (142), Expect = 4e-09 Identities = 35/108 (32%), Positives = 64/108 (59%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 E+L E+ + + L H+NI++F+ + D ++++ F E+ + +L + ++ + Sbjct: 78 EKLTREVEIHRQLSHRNIVQFHHFFED--SQNVYFTLELCSKNSLMELNKQRGPLTEHEA 135 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + Q+ G+ +LH N IIHRDLK N+F+N + +VKIGD GLA Sbjct: 136 RFYTIQVAEGVKHLH--NLQIIHRDLKLGNLFLNEHL-QVKIGDFGLA 180
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 59.3 bits (142), Expect = 4e-09 Identities = 34/110 (30%), Positives = 61/110 (55%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P +LE++Y E+ ++K L H +I+K Y V + + +TE +G + + + ++ Sbjct: 64 PSNLEKIYREVQIMKLLNHPHIIKLYQ--VMETKDMLYIVTEFAKNGEMFDHLTSNGHLS 121 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + QILS + Y HSH+ I+HRDLK +N+ ++ N +K+ D G Sbjct: 122 ESEARKKFWQILSAVEYCHSHH--IVHRDLKTENLLLDANM-NIKLADFG 168
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 58.9 bits (141), Expect = 5e-09 Identities = 48/140 (34%), Positives = 73/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDV 206 TV++A + VA +V+L D + P R EI LLK LKHKNI++ + V Sbjct: 17 TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKHKNIVRLHD--VLH 71 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S + + + E + + + ++ VK Q+L GL + HS N ++HRDLK Sbjct: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLGFCHSRN--VLHRDLKP 129 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N N GE+K+ D GLA Sbjct: 130 QNLLINRN-GELKLADFGLA 148
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 58.9 bits (141), Expect = 5e-09 Identities = 40/130 (30%), Positives = 68/130 (52%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA +K+ D Q P L++L+ E+ ++K L H NI+K + V + + + I E Sbjct: 79 GREVA---IKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE--VIETEKTLYLIME 133 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++ + Sbjct: 134 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKR--IVHRDLKAENLLLDADM- 190 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 191 NIKITDFGFS 200
>STY1_SCHPO (Q09892) Mitogen-activated protein kinase sty1 (EC 2.7.11.24) (MAP| kinase sty1) (MAP kinase spc1) Length = 349 Score = 58.9 bits (141), Expect = 5e-09 Identities = 49/138 (35%), Positives = 70/138 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V A D+ GM VA K+ P +R Y E+ LLK L+H+NI+ ++ Sbjct: 34 VCSAKDQLTGMNVAVK--KIMKPFSTPVLAKRTYRELKLLKHLRHENIISLSDIFIS-PF 90 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I F+TE+ GT R + ++ + QIL GL ++HS +IHRDLK N Sbjct: 91 EDIYFVTELL--GTDLHRLLTSRPLETQFIQYFLYQILRGLKFVHSAG--VIHRDLKPSN 146 Query: 393 IFVNGNQGEVKIGDLGLA 446 I +N N ++KI D GLA Sbjct: 147 ILINEN-CDLKICDFGLA 163
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 58.9 bits (141), Expect = 5e-09 Identities = 45/144 (31%), Positives = 75/144 (52%), Gaps = 5/144 (3%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV+RA E+ G +VA + DF + + E+ ++K L+H NI+ F + Sbjct: 564 TVHRA--EWHGSDVAVKILMEQDFHA--ERVNEFLREVAIMKRLRHPNIVLFMGAVTQPP 619 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR-----QILSGLLYLHSHNPPIIHR 374 +++ +TE + G+L YR H+ + + R + G+ YLH+ NPPI+HR Sbjct: 620 --NLSIVTEYLSRGSL--YRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHR 675 Query: 375 DLKCDNIFVNGNQGEVKIGDLGLA 446 DLK N+ V+ + VK+ D GL+ Sbjct: 676 DLKSPNLLVD-KKYTVKVCDFGLS 698
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 58.9 bits (141), Expect = 5e-09 Identities = 36/103 (34%), Positives = 55/103 (53%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +L LKH N++ Y +++ ++ F F L Q+ + K+ I + Sbjct: 51 EIAVLLELKHPNVVDLYDIYLEDKFLYLVF---EFCDEDLYQFMSRSSKIPINETRSIVY 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QIL GL + H H I+HRD+K NI +N N G +K+G+ GLA Sbjct: 108 QILQGLAFCHYHQ--ILHRDMKPQNILINKN-GTIKLGEFGLA 147
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 58.5 bits (140), Expect = 7e-09 Identities = 40/130 (30%), Positives = 68/130 (52%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA VK+ D Q P L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 83 GREVA---VKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE--VIETEKTLYLVME 137 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++ + Sbjct: 138 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKC--IVHRDLKAENLLLDADM- 194 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 195 NIKIADFGFS 204
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 58.5 bits (140), Expect = 7e-09 Identities = 41/138 (29%), Positives = 72/138 (52%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V RA + + G VA ++ D ++ D+ + EI ++ +L H +I+ Y V + Sbjct: 70 VKRATERFSGRVVAIKSIRK-DKIKDELDMVHIRREIEIMSSLNHPHIISIYE--VFENK 126 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I I E + G L Y + R+++ + + RQI+S + Y H + ++HRDLK +N Sbjct: 127 DKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNG--VVHRDLKLEN 184 Query: 393 IFVNGNQGEVKIGDLGLA 446 I ++ N +KI D GL+ Sbjct: 185 ILLDDN-CNIKIADFGLS 201
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 58.5 bits (140), Expect = 7e-09 Identities = 40/130 (30%), Positives = 68/130 (52%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA VK+ D Q P L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 83 GREVA---VKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE--VIETEKTLYLVME 137 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++ + Sbjct: 138 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKC--IVHRDLKAENLLLDADM- 194 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 195 NIKIADFGFS 204
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 58.5 bits (140), Expect = 7e-09 Identities = 47/141 (33%), Positives = 73/141 (51%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKL-YDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A + G VA +++L + P R EI LLK LKH NI++ V + Sbjct: 18 VYKAKNRETGQLVALKKIRLDLEMEGVPSTAIR---EISLLKELKHPNIVRLLD--VVHN 72 Query: 210 ARHINFITEMFTSGTLRQYRQKH--RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 R + + E F S L++Y ++ + +K + Q+L G+ + HSH +IHRDLK Sbjct: 73 ERKLYLVFE-FLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHR--VIHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N G +K+ D GLA Sbjct: 130 PQNLLIN-ELGAIKLADFGLA 149
>PLK1_XENTR (P62205) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Plx1) Length = 598 Score = 58.5 bits (140), Expect = 7e-09 Identities = 37/132 (28%), Positives = 72/132 (54%) Frame = +3 Query: 51 EYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFI 230 + + EV ++ L P +++ EI + ++L H++++ F+ + D ++ + Sbjct: 63 DLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYV--V 120 Query: 231 TEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGN 410 E+ +L + ++ + V + + +Q + G YLHS+ +IHRDLK N+F+N + Sbjct: 121 LELCRRRSLLELHKRRKAVTEPEARYYLKQTILGCQYLHSNR--VIHRDLKLGNLFLN-D 177 Query: 411 QGEVKIGDLGLA 446 + EVKIGD GLA Sbjct: 178 EMEVKIGDFGLA 189
>CDK3_MOUSE (Q80YP0) Truncated cell division protein kinase 3 homolog| Length = 186 Score = 58.5 bits (140), Expect = 7e-09 Identities = 47/141 (33%), Positives = 71/141 (50%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY+A ++ G VA +++L L+ EI LLK LKH NI+K +DV Sbjct: 18 VYKARNKVTGQLVALKKIRLD--LEAEGVPSTAVREISLLKELKHPNIIKL----LDVVH 71 Query: 213 RH--INFITEMFTSGTLRQYRQKHR-KVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 R + + E T R ++ + VK + Q+L G+ + HSH +IHRDLK Sbjct: 72 REKKLYMVFEFLTQDLKRHMDSSPTSELPLPVVKSYLAQLLEGVSFCHSHR--VIHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ ++G G +K+ D GLA Sbjct: 130 PQNLLLDG-LGAIKLADFGLA 149
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 58.2 bits (139), Expect = 9e-09 Identities = 37/113 (32%), Positives = 61/113 (53%) Frame = +3 Query: 102 LQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR 281 LQC E + EI +++ H NI+ + S++ V RH+ + E +G+L +K Sbjct: 347 LQCQTRKELILNEITVMRESIHPNIVTYLDSFL-VRERHLWVVMEYMNAGSLTDIIEKS- 404 Query: 282 KVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 K+ + C + G+ +LH+ N IIHRD+K DN+ ++ N G +KI D G Sbjct: 405 KLTEAQIARICLETCKGIQHLHARN--IIHRDIKSDNVLLD-NSGNIKITDFG 454
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 58.2 bits (139), Expect = 9e-09 Identities = 39/107 (36%), Positives = 56/107 (52%), Gaps = 3/107 (2%) Frame = +3 Query: 129 LYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKH---RKVNIWA 299 L+ EI L K LKHKNI+++ S+ + I E G+L + K N Sbjct: 722 LHEEIALHKHLKHKNIVQYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNEQT 779 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + + +QIL GL YLH + I+HRD+K DN+ +N G +KI D G Sbjct: 780 IGFYTKQILEGLKYLHDNQ--IVHRDIKGDNVLINTYSGVLKISDFG 824
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 58.2 bits (139), Expect = 9e-09 Identities = 36/107 (33%), Positives = 59/107 (55%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 ++ L E+ LLK L H NI+++ + + +N + E G++ +K Sbjct: 116 IQELEEEVKLLKNLSHPNIVRYLGTVREDDT--LNILLEFVPGGSISSLLEKFGPFPESV 173 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 V+ + RQ+L GL YLH+H I+HRD+K NI V+ N+G +K+ D G Sbjct: 174 VRTYTRQLLLGLEYLHNH--AIMHRDIKGANILVD-NKGCIKLADFG 217
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 58.2 bits (139), Expect = 9e-09 Identities = 39/107 (36%), Positives = 56/107 (52%), Gaps = 3/107 (2%) Frame = +3 Query: 129 LYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKH---RKVNIWA 299 L+ EI L K LKHKNI+++ S+ + I E G+L + K N Sbjct: 729 LHEEIALHKHLKHKNIVQYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNEQT 786 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + + +QIL GL YLH + I+HRD+K DN+ +N G +KI D G Sbjct: 787 IGFYTKQILEGLKYLHDNQ--IVHRDIKGDNVLINTYSGVLKISDFG 831
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 57.8 bits (138), Expect = 1e-08 Identities = 36/107 (33%), Positives = 58/107 (54%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 ++ L E+ LLK L H NI+++ + + +N + E G++ +K Sbjct: 115 IQELEEEVKLLKNLSHPNIVRYLGTVREDET--LNILLEFVPGGSISSLLEKFGAFPESV 172 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 V+ + Q+L GL YLH+H I+HRD+K NI V+ NQG +K+ D G Sbjct: 173 VRTYTNQLLLGLEYLHNH--AIMHRDIKGANILVD-NQGCIKLADFG 216
>PLK1_MOUSE (Q07832) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) Length = 603 Score = 57.8 bits (138), Expect = 1e-08 Identities = 35/112 (31%), Positives = 64/112 (57%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI + ++L H++++ F+ + D + + + E+ +L + ++ + + Sbjct: 92 PHQKEKMSMEISIHRSLAHQHVVGFHDFFED--SDFVFVVLELCRRRSLLELHKRRKALT 149 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + RQI+ G YLH + +IHRDLK N+F+N + EVKIGD GLA Sbjct: 150 EPEARYYLRQIVLGCQYLHRNQ--VIHRDLKLGNLFLNEDL-EVKIGDFGLA 198
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 57.4 bits (137), Expect = 2e-08 Identities = 34/106 (32%), Positives = 57/106 (53%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIW 296 +LE++Y E+ ++K L H +I+K Y S ++ +TE +G + Y H ++N Sbjct: 60 NLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYL--VTEYAKNGEIFDYLANHGRLNES 117 Query: 297 AVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGD 434 + QILS + Y H I+HRDLK +N+ ++ N +KI D Sbjct: 118 EARRKFWQILSAVDYCHGRK--IVHRDLKAENLLLDNNM-NIKIAD 160
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 57.4 bits (137), Expect = 2e-08 Identities = 33/110 (30%), Positives = 61/110 (55%), Gaps = 3/110 (2%) Frame = +3 Query: 126 RLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVK 305 R+ EI +K L+H+NI++FY ++ + ++ + E+ G+L Y ++ ++ Sbjct: 51 RIKEEIKTMKLLRHRNIVQFYETFFENGETYL--VMELCEGGSLMDYVKQKGPLDDSTAV 108 Query: 306 DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNG---NQGEVKIGDLGLA 446 RQ+++ + Y+H N I+HRDL N+F+ + VK+GD GLA Sbjct: 109 HILRQLIAAVKYIHDEN--ILHRDLSAGNVFIKDATKSTITVKLGDFGLA 156
>ZYG1_CAEEL (Q9GT24) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 706 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/111 (31%), Positives = 64/111 (57%), Gaps = 4/111 (3%) Frame = +3 Query: 126 RLYCEIHLLKTLKH-KNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 R++ EI +K LK K +++FY +V+ +I + E+ G+L+ Y ++H ++ Sbjct: 51 RVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYI--VMELCEGGSLQAYVREHGALDDATA 108 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGE---VKIGDLGLA 446 RQ++S + ++H N +IHRDL N+F+ ++ + VK+GD GLA Sbjct: 109 VHVLRQLISAVSFMHRVN--VIHRDLSAGNVFIKDSKKKKMTVKLGDFGLA 157
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 57.4 bits (137), Expect = 2e-08 Identities = 47/154 (30%), Positives = 73/154 (47%), Gaps = 16/154 (10%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSW--VDV 206 V++A G A +VK + E+ E+ L L H NI+++++ W VD Sbjct: 256 VFKAKHRIDGKRYAIKRVKY--------NTEKAEHEVQALAELNHVNIVQYHSCWEGVDY 307 Query: 207 SARHINFITEMFTS------------GTLRQYRQKHR--KVNIWAVKDWCRQILSGLLYL 344 H T + + GTL Q+ + KV+ + D QI++G+ Y+ Sbjct: 308 DPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYI 367 Query: 345 HSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 HS +IHRDLK NIF+ ++ +KIGD GLA Sbjct: 368 HSKG--LIHRDLKPGNIFL-VDERHIKIGDFGLA 398
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 57.4 bits (137), Expect = 2e-08 Identities = 40/136 (29%), Positives = 71/136 (52%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY A ++ G VA + + +Q + +++ EI + L+HKNI++ Y + D Sbjct: 103 VYLAKEKKTGFIVALKTLHKSELVQSKIE-KQVRREIEIQSNLRHKNILRLYGHFHD--E 159 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 + I I E G L Q+ ++ ++ + + Q+ + L YLH + +IHRD+K +N Sbjct: 160 KRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKH--VIHRDIKPEN 217 Query: 393 IFVNGNQGEVKIGDLG 440 I + G GE+K+ D G Sbjct: 218 ILL-GIDGEIKLSDFG 232
>CDC2H_PLAVI (Q9XZD6) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (Pvcrk2) Length = 288 Score = 57.4 bits (137), Expect = 2e-08 Identities = 36/103 (34%), Positives = 53/103 (51%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK LKH NI+K Y V + + + + E + + K + Sbjct: 50 EISILKELKHSNIVKLYD--VIHTKKRLILVFEHLDQDLKKLLDVCDGGLESVTAKSFLL 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+LSG+ Y H H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 108 QLLSGIAYCHEHR--VLHRDLKPQNLLIN-REGELKIADFGLA 147
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 57.4 bits (137), Expect = 2e-08 Identities = 36/103 (34%), Positives = 53/103 (51%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK LKH NI+K Y V + + + + E + + K + Sbjct: 50 EISILKELKHSNIVKLYD--VIHTKKRLILVFEHLDQDLKKLLDVCDGGLESVTAKSFLL 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+LSG+ Y H H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 108 QLLSGIAYCHEHR--VLHRDLKPQNLLIN-REGELKIADFGLA 147
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 56.6 bits (135), Expect = 3e-08 Identities = 33/103 (32%), Positives = 56/103 (54%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI LLK LKH NI++ + V + R + + E + + +++ +K + Sbjct: 51 EISLLKELKHPNIVRLHD--VIHTERKLTLVFEYLDQDLKKYLDECGGEISKPTIKSFMY 108 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L G+ + H H ++HRDLK N+ +N +GE+K+ D GLA Sbjct: 109 QLLKGVAFCHDHR--VLHRDLKPQNLLIN-RKGELKLADFGLA 148
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 56.6 bits (135), Expect = 3e-08 Identities = 39/138 (28%), Positives = 70/138 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY + G +A ++KL D +++++ E+ +L+ L H N++ +Y V+V Sbjct: 1051 VYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYY--GVEVHR 1108 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 + E G+L R + +K + Q+L GL Y+HS + I+HRD+K N Sbjct: 1109 EKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQH--ILHRDIKPAN 1166 Query: 393 IFVNGNQGEVKIGDLGLA 446 I ++ ++G +K D G A Sbjct: 1167 ILLD-HRGMIKYSDFGSA 1183
>PLK1_HUMAN (P53350) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) Length = 603 Score = 56.6 bits (135), Expect = 3e-08 Identities = 35/112 (31%), Positives = 63/112 (56%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ EI + ++L H++++ F+ + D + + E+ +L + ++ + + Sbjct: 92 PHQREKMSMEISIHRSLAHQHVVGFHGFFEDND--FVFVVLELCRRRSLLELHKRRKALT 149 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + RQI+ G YLH + +IHRDLK N+F+N + EVKIGD GLA Sbjct: 150 EPEARYYLRQIVLGCQYLHRNR--VIHRDLKLGNLFLNEDL-EVKIGDFGLA 198
>SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC 2.7.11.1)| (STE20-like kinase sid1) Length = 471 Score = 56.6 bits (135), Expect = 3e-08 Identities = 40/138 (28%), Positives = 69/138 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V++A + G +A Q+ L + DD+ + E+ +L N++++Y +VD Sbjct: 23 VWKARENVSGDIIAIKQIDLETGI---DDITDIEQEVFMLSNCNSSNVIQYYGCFVDGYT 79 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I + E G++ + R +N + R++L GL YLH N IHRD+K N Sbjct: 80 LWI--LMEHMDGGSVSGLLKMGR-LNEQVISIILREVLYGLNYLHGQNK--IHRDIKAAN 134 Query: 393 IFVNGNQGEVKIGDLGLA 446 I ++ + G VK+ D G+A Sbjct: 135 ILLSSSTGNVKLADFGVA 152
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 56.6 bits (135), Expect = 3e-08 Identities = 36/105 (34%), Positives = 58/105 (55%) Frame = +3 Query: 126 RLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVK 305 ++Y EI+ LK L H NI+K V ++R+I + E G +Y QK R++ Sbjct: 96 KIYREINALKHLSHPNIVKLEE--VLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNAC 153 Query: 306 DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 Q++SG+ Y+HS ++HRDLK +N+ ++ N+ V I D G Sbjct: 154 RLFSQLISGVHYIHSKG--LVHRDLKLENLLLDKNENLV-ITDFG 195
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 56.2 bits (134), Expect = 4e-08 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ + E+ +L+ +H NI+ F ++ Sbjct: 95 TVYKG--KWHG-DVAVKILKVVD--PTPEQFQAFRNEVAVLRKTRHVNILLFMGY---MT 146 Query: 210 ARHINFITEMFTSGTLRQYRQ-KHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 ++ +T+ +L ++ + K ++ + D RQ G+ YLH+ N IIHRD+K Sbjct: 147 KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKS 204 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +NIF++G VKIGD GLA Sbjct: 205 NNIFLHGGL-TVKIGDFGLA 223
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 56.2 bits (134), Expect = 4e-08 Identities = 39/130 (30%), Positives = 67/130 (51%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA VK+ D Q L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 76 GKEVA---VKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE--VIETEKTLYLVME 130 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++ + Sbjct: 131 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF--IVHRDLKAENLLLDADM- 187 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 188 NIKIADFGFS 197
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 56.2 bits (134), Expect = 4e-08 Identities = 36/113 (31%), Positives = 61/113 (53%), Gaps = 3/113 (2%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIW 296 D + L E+ LLK L H NIMK Y + D + ++ ++++++ G L ++ Sbjct: 110 DKQSLLREVELLKMLDHINIMKLYEFFEDNNYYYL--VSDVYSGGELFDEIISRKRFYEV 167 Query: 297 AVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGE---VKIGDLGLA 446 +Q+LSG+ Y+H +N ++HRDLK +NI + E +KI D GL+ Sbjct: 168 DAARIIKQVLSGITYMHKNN--VVHRDLKPENILLETKNKEDMIIKIIDFGLS 218
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 56.2 bits (134), Expect = 4e-08 Identities = 36/113 (31%), Positives = 61/113 (53%), Gaps = 3/113 (2%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIW 296 D + L E+ LLK L H NIMK Y + D + ++ ++++++ G L ++ Sbjct: 110 DKQSLLREVELLKMLDHINIMKLYEFFEDNNYYYL--VSDVYSGGELFDEIISRKRFYEV 167 Query: 297 AVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGE---VKIGDLGLA 446 +Q+LSG+ Y+H +N ++HRDLK +NI + E +KI D GL+ Sbjct: 168 DAARIIKQVLSGITYMHKNN--VVHRDLKPENILLETKNKEDMIIKIIDFGLS 218
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 56.2 bits (134), Expect = 4e-08 Identities = 39/130 (30%), Positives = 67/130 (51%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA VK+ D Q L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 76 GKEVA---VKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE--VIETEKTLYLVME 130 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+S + Y H I+HRDLK +N+ ++ + Sbjct: 131 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF--IVHRDLKAENLLLDADM- 187 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 188 NIKIADFGFS 197
>PLK1_RAT (Q62673) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) Length = 603 Score = 56.2 bits (134), Expect = 4e-08 Identities = 34/112 (30%), Positives = 64/112 (57%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P E++ E + ++L+H++++ F+ + D + + + E+ +L + ++ + + Sbjct: 92 PHQKEKMSMETSIHRSLEHQHVVGFHGFFED--SDFVFVVLELCRRRSLLELHKRRKALT 149 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + RQI+ G YLH + +IHRDLK N+F+N + EVKIGD GLA Sbjct: 150 EPEARYYLRQIVLGCQYLHRNQ--VIHRDLKLGNLFLNEDL-EVKIGDFGLA 198
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 56.2 bits (134), Expect = 4e-08 Identities = 42/139 (30%), Positives = 69/139 (49%), Gaps = 1/139 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A G +VA +++L + P R EI LLK LKH N+++ + V +S Sbjct: 22 VYKARSNSTGQDVALKKIRLEGETEGVPSTAIR---EISLLKNLKHPNVVQLFD--VVIS 76 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 ++ I E + +K +K + QIL + + H++ I+HRDLK Sbjct: 77 GNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNR--ILHRDLKPQ 134 Query: 390 NIFVNGNQGEVKIGDLGLA 446 N+ V+ G++K+ D GLA Sbjct: 135 NLLVD-TAGKIKLADFGLA 152
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 55.8 bits (133), Expect = 5e-08 Identities = 46/139 (33%), Positives = 70/139 (50%), Gaps = 2/139 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV+ A D G EVA Q+ L Q E + EI ++K LK+ NI+ F S++ Sbjct: 262 TVFTATDVALGQEVAIKQINL----QKQPKKELIINEILVMKELKNPNIVNFLDSYL--V 315 Query: 210 ARHINFITEMFTSGTLRQYRQKH--RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E G+L + + I AV CR+ L L +LH++ +IHRD+K Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAV---CRECLQALEFLHANQ--VIHRDIK 370 Query: 384 CDNIFVNGNQGEVKIGDLG 440 DN+ + G +G VK+ D G Sbjct: 371 SDNVLL-GMEGSVKLTDFG 388
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 55.8 bits (133), Expect = 5e-08 Identities = 46/139 (33%), Positives = 70/139 (50%), Gaps = 2/139 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV+ A D G EVA Q+ L Q E + EI ++K LK+ NI+ F S++ Sbjct: 262 TVFTATDVALGQEVAIKQINL----QKQPKKELIINEILVMKELKNPNIVNFLDSYL--V 315 Query: 210 ARHINFITEMFTSGTLRQYRQKH--RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E G+L + + I AV CR+ L L +LH++ +IHRD+K Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAV---CRECLQALEFLHANQ--VIHRDIK 370 Query: 384 CDNIFVNGNQGEVKIGDLG 440 DN+ + G +G VK+ D G Sbjct: 371 SDNVLL-GMEGSVKLTDFG 388
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 55.8 bits (133), Expect = 5e-08 Identities = 46/139 (33%), Positives = 70/139 (50%), Gaps = 2/139 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV+ A D G EVA Q+ L Q E + EI ++K LK+ NI+ F S++ Sbjct: 262 TVFTATDVALGQEVAIKQINL----QKQPKKELIINEILVMKELKNPNIVNFLDSYL--V 315 Query: 210 ARHINFITEMFTSGTLRQYRQKH--RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E G+L + + I AV CR+ L L +LH++ +IHRD+K Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAV---CRECLQALEFLHANQ--VIHRDIK 370 Query: 384 CDNIFVNGNQGEVKIGDLG 440 DN+ + G +G VK+ D G Sbjct: 371 SDNVLL-GMEGSVKLTDFG 388
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 55.8 bits (133), Expect = 5e-08 Identities = 46/139 (33%), Positives = 70/139 (50%), Gaps = 2/139 (1%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV+ A D G EVA Q+ L Q E + EI ++K LK+ NI+ F S++ Sbjct: 262 TVFTATDVALGQEVAIKQINL----QKQPKKELIINEILVMKELKNPNIVNFLDSYL--V 315 Query: 210 ARHINFITEMFTSGTLRQYRQKH--RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E G+L + + I AV CR+ L L +LH++ +IHRD+K Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAV---CRECLQALEFLHANQ--VIHRDIK 370 Query: 384 CDNIFVNGNQGEVKIGDLG 440 DN+ + G +G VK+ D G Sbjct: 371 SDNVLL-GMEGSVKLTDFG 388
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 55.8 bits (133), Expect = 5e-08 Identities = 41/138 (29%), Positives = 65/138 (47%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY A D G +A ++ + D + E+ +L+ L H NI+ +Y V+V Sbjct: 1280 VYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVSYYG--VEVHR 1337 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 +N E G+L + R + + + Q+L GL YLH I+HRD+K +N Sbjct: 1338 DKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESG--IVHRDVKPEN 1395 Query: 393 IFVNGNQGEVKIGDLGLA 446 I ++ N G +K D G A Sbjct: 1396 ILLDFN-GVIKYVDFGAA 1412
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 55.8 bits (133), Expect = 5e-08 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 3/142 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + G VA ++ L P R EI L+K LKH+NI+ Y V + Sbjct: 20 TVYKGRNRTTGQLVALKEINLDSEEGTPSTAIR---EISLMKELKHENIVTLYD--VIHT 74 Query: 210 ARHINFITEMFTSGTLRQYRQKHRK---VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 +N + E + L+++ + + VK + Q+L G+L+ H + ++HRDL Sbjct: 75 ENKLNLVFE-YMDKDLKKFMDTNGNKGALETKQVKWFMYQLLRGILFCHDNR--VLHRDL 131 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ +N +G++K+ D GLA Sbjct: 132 KPQNLLINA-KGQLKLADFGLA 152
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 55.8 bits (133), Expect = 5e-08 Identities = 41/138 (29%), Positives = 69/138 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY+A ++ G VA +++L D P R EI LLK + H N++ + + Sbjct: 24 VYKAKEKATGRMVALKKIRLEDD-GVPSTALR---EISLLKEVPHPNVVSLFDV---LHC 76 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 ++ ++ + L++Y + +K + Q+L GL Y H H I+HRDLK N Sbjct: 77 QNRLYLVFEYLDQDLKKYMDSVPALCPQLIKSYLYQLLKGLAYSHGHR--ILHRDLKPQN 134 Query: 393 IFVNGNQGEVKIGDLGLA 446 + ++ QG +K+ D GLA Sbjct: 135 LLID-RQGALKLADFGLA 151
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 55.8 bits (133), Expect = 5e-08 Identities = 35/112 (31%), Positives = 56/112 (50%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVN 290 P +ER EI ++K + H N+M + W + S ++ + E G L Y K+ Sbjct: 158 PYGIER---EIVIMKLISHTNVMALFEVWENKSELYL--VLEYVDGGELFDYLVSKGKLP 212 Query: 291 IWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + +QI+ G+ Y HS N I HRDLK +N+ ++ +KI D G+A Sbjct: 213 EREAIHYFKQIVEGVSYCHSFN--ICHRDLKPENLLLDKKNRRIKIADFGMA 262
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 55.8 bits (133), Expect = 5e-08 Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 3/115 (2%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKH---R 281 P L+ E+ +LK +H NI+ F VS + +T+ +L Y+ H Sbjct: 464 PAQLQAFKNEVAMLKKTRHCNILLFMGC---VSKPSLAIVTQWCEGSSL--YKHVHVSET 518 Query: 282 KVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 K + + D RQ+ G+ YLH+ N IIHRDLK +NIF++ + VKIGD GLA Sbjct: 519 KFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHEDL-SVKIGDFGLA 570
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 55.8 bits (133), Expect = 5e-08 Identities = 36/109 (33%), Positives = 59/109 (54%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 ++ L E++LLK L H+NI+ +Y + ++N E G++ + Sbjct: 519 VDALQHEMNLLKELHHENIVTYYGA--SQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESL 576 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + ++ RQIL G+ YLH N IIHRD+K NI ++ +G VKI D G++ Sbjct: 577 ITNFTRQILIGVAYLHKKN--IIHRDIKGANILID-IKGCVKITDFGIS 622
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 55.5 bits (132), Expect = 6e-08 Identities = 43/141 (30%), Positives = 71/141 (50%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A + G VA +++L + P R EI LLK L H NI+K + Sbjct: 18 VYKARNRETGEIVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHR--KVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F + L+++ +++ VK + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N + G +K+ D GLA Sbjct: 130 PQNLLIN-SDGAIKLADFGLA 149
>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)| (NimA-related protein kinase 8) Length = 697 Score = 55.5 bits (132), Expect = 6e-08 Identities = 41/107 (38%), Positives = 57/107 (53%), Gaps = 4/107 (3%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E +LK L H NI+++Y ++++ A I E GTL Y QK + N +D Sbjct: 51 ECQVLKLLSHPNIIEYYENFLEDKALMIAM--EYAPGGTLADYIQK--RCNSLLDEDTIL 106 Query: 318 ----QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QIL L H HN I+HRDLK NI ++ +Q VKIGD G++ Sbjct: 107 HSFVQILLALY--HVHNKLILHRDLKTQNILLDKHQMIVKIGDFGIS 151
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 55.5 bits (132), Expect = 6e-08 Identities = 39/138 (28%), Positives = 67/138 (48%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY A + G +A ++K++D + E+ +L+ L H NI+++Y V+V Sbjct: 1048 VYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYG--VEVHR 1105 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 +N E G+L R + + + ++L GL YLH ++HRD+K +N Sbjct: 1106 DKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSG--VVHRDIKPEN 1163 Query: 393 IFVNGNQGEVKIGDLGLA 446 I ++ N G +K D G A Sbjct: 1164 ILLDFN-GIIKYVDFGTA 1180
>MK14A_CYPCA (Q90336) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a) Length = 361 Score = 55.5 bits (132), Expect = 6e-08 Identities = 50/143 (34%), Positives = 72/143 (50%), Gaps = 4/143 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV A+DE G++VA KL Q +R Y E+ LLK +KH+N++ + + Sbjct: 38 TVCSAYDEKTGLKVAVK--KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPAT 95 Query: 210 A----RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRD 377 + + +T + G K +K+ V+ QIL GL Y+HS + IIHRD Sbjct: 96 SLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD--IIHRD 151 Query: 378 LKCDNIFVNGNQGEVKIGDLGLA 446 LK N+ VN E+KI D GLA Sbjct: 152 LKPSNLAVN-EDCELKILDFGLA 173
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 55.1 bits (131), Expect = 8e-08 Identities = 43/141 (30%), Positives = 69/141 (48%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K + Sbjct: 18 VYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWA--VKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F L+++ I +K + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N +G +K+ D GLA Sbjct: 130 PQNLLINA-EGSIKLADFGLA 149
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 55.1 bits (131), Expect = 8e-08 Identities = 43/141 (30%), Positives = 69/141 (48%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K + Sbjct: 18 VYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWA--VKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F L+++ I +K + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLHQDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N +G +K+ D GLA Sbjct: 130 PQNLLINA-EGSIKLADFGLA 149
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 55.1 bits (131), Expect = 8e-08 Identities = 45/140 (32%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + VA +++L P R E+ LLK LKH NI+ + + + Sbjct: 178 TVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR---EVSLLKDLKHANIVTLHD--IIHT 232 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + E + L+QY V N+ VK + Q+L GL Y H ++HRDLK Sbjct: 233 EKSLTLVFE-YLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQK--VLHRDLKP 289 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N +GE+K+ D GLA Sbjct: 290 QNLLIN-ERGELKLADFGLA 308
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 55.1 bits (131), Expect = 8e-08 Identities = 45/140 (32%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + VA +++L P R E+ LLK LKH NI+ + + + Sbjct: 178 TVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR---EVSLLKDLKHANIVTLHD--IIHT 232 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + E + L+QY V N+ VK + Q+L GL Y H ++HRDLK Sbjct: 233 EKSLTLVFE-YLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQK--VLHRDLKP 289 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N +GE+K+ D GLA Sbjct: 290 QNLLIN-ERGELKLADFGLA 308
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 55.1 bits (131), Expect = 8e-08 Identities = 34/103 (33%), Positives = 53/103 (51%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK L+H NI+K Y V + + + + E + + K + Sbjct: 51 EISILKELRHSNIVKLYD--VIHAKKRLILVFEHLDQDLKKLIDVCDGGLESVTAKSFLL 108 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L+G+ Y H H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 109 QLLNGIAYCHEHR--VLHRDLKPQNLLIN-REGELKIADFGLA 148
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 55.1 bits (131), Expect = 8e-08 Identities = 36/111 (32%), Positives = 59/111 (53%) Frame = +3 Query: 114 DDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNI 293 D + ++ EI L +H +I++ Y V + I I E + G L Y KH ++ Sbjct: 127 DVVGKIRREIQNLSLFRHPHIIRLYQ--VISTPSDIFMIMEHVSGGELFDYIVKHGRLKT 184 Query: 294 WAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + +QI+SG+ Y H H ++HRDLK +N+ ++ Q VKI D GL+ Sbjct: 185 AEARRFFQQIISGVDYCHRH--MVVHRDLKPENLLLD-EQNNVKIADFGLS 232
>M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Length = 847 Score = 55.1 bits (131), Expect = 8e-08 Identities = 41/138 (29%), Positives = 69/138 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY+A + + G A +KL + DD + EI ++K KH NI+ ++ S+ +S Sbjct: 34 VYKARNVHTGELAAVKIIKL----EPGDDFSLIQQEIFMVKECKHCNIVAYFGSY--LSR 87 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 + E G+L+ ++ + CR+ L GL YLH+ +HRD+K N Sbjct: 88 EKLWICMEYCGGGSLQDIYHVTGPLSEMQIAYVCRETLQGLAYLHTKGK--MHRDIKGAN 145 Query: 393 IFVNGNQGEVKIGDLGLA 446 I + + G+VK+ D G+A Sbjct: 146 ILLT-DHGDVKLADFGVA 162
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 55.1 bits (131), Expect = 8e-08 Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%) Frame = +3 Query: 129 LYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQK---HRKVNIWA 299 L+ EI L + L+HKNI+++ S ++ E G+L + K N Sbjct: 413 LHEEIALHRRLRHKNIVRYLGS--ASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNEST 470 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + + RQIL GL YLH ++ I+HRD+K DN+ +N G +KI D G Sbjct: 471 ISFYTRQILQGLGYLHDNH--IVHRDIKGDNVLINTFSGLLKISDFG 515
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 55.1 bits (131), Expect = 8e-08 Identities = 34/103 (33%), Positives = 53/103 (51%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK L+H NI+K Y V + + + + E + + K + Sbjct: 50 EISILKELRHSNIVKLYD--VIHAKKRLILVFEHLDQDLKKLIDVCDGGLESVTAKSFLL 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L+G+ Y H H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 108 QLLNGIAYCHEHR--VLHRDLKPQNLLIN-REGELKIADFGLA 147
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 55.1 bits (131), Expect = 8e-08 Identities = 34/103 (33%), Positives = 53/103 (51%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK L+H NI+K Y V + + + + E + + K + Sbjct: 50 EISILKELRHSNIVKLYD--VIHAKKRLILVFEHLDQDLKKLIDVCDGGLESVTAKSFLL 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L+G+ Y H H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 108 QLLNGIAYCHEHR--VLHRDLKPQNLLIN-REGELKIADFGLA 147
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 55.1 bits (131), Expect = 8e-08 Identities = 37/110 (33%), Positives = 54/110 (49%), Gaps = 1/110 (0%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQY-RQKHRKVNIW 296 +E E ++K L+H +++ Y V I +TE+ G+L +Y R R + + Sbjct: 277 IEEFLEEASIMKQLRHPKLIQLYA--VCTKEEPIYIVTELMKHGSLLEYLRGDGRSLKLP 334 Query: 297 AVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + D C Q+ SG+ YL N IHRDL NI V G K+ D GLA Sbjct: 335 DLVDMCSQVASGMSYLEQQN--YIHRDLAARNILV-GEHKICKVADFGLA 381
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 55.1 bits (131), Expect = 8e-08 Identities = 39/138 (28%), Positives = 66/138 (47%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V+ A D G VA + L P + EI +++ L H NI+K + V + Sbjct: 35 VFHARDRRTGQSVAVKILNKKKLLTNPALANNIKREISIMRRLSHPNIVKLHE--VMATK 92 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I F E G L KH +++ + + +Q++S + Y H+ + HRDLK +N Sbjct: 93 SKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQLISAVGYCHARG--VYHRDLKPEN 150 Query: 393 IFVNGNQGEVKIGDLGLA 446 + ++ N G +K+ D GL+ Sbjct: 151 LLIDEN-GNLKVSDFGLS 167
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/108 (37%), Positives = 60/108 (55%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R Y E+ LLK L+H+N++ ++ I F+TE+ GT + R + V Sbjct: 65 KRTYRELKLLKHLRHENLICLQDIFLS-PLEDIYFVTEL--QGTDLHRLLQTRPLEKQFV 121 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QIL GL Y+HS +IHRDLK NI +N N ++KI D GLA Sbjct: 122 QYFLYQILRGLKYVHSAG--VIHRDLKPSNILINEN-CDLKICDFGLA 166
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 54.7 bits (130), Expect = 1e-07 Identities = 43/141 (30%), Positives = 69/141 (48%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K + Sbjct: 18 VYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWA--VKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F L+++ I +K + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N +G +K+ D GLA Sbjct: 130 PQNLLIN-TEGAIKLADFGLA 149
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 54.7 bits (130), Expect = 1e-07 Identities = 43/141 (30%), Positives = 69/141 (48%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K + Sbjct: 18 VYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWA--VKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F L+++ I +K + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N + G +K+ D GLA Sbjct: 130 PQNLLINAD-GSIKLADFGLA 149
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 54.7 bits (130), Expect = 1e-07 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ L+ E+ +L+ +H NI+ F ++ Sbjct: 362 TVYKG--KWHG-DVAVKILKVVD--PTPEQLQAFRNEVAVLRKTRHVNILLFMGY---MT 413 Query: 210 ARHINFITEMFTSGTLRQYRQ-KHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 ++ +T+ +L ++ + K ++ + D RQ G+ YLH+ N IIHRD+K Sbjct: 414 KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKS 471 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +NIF++ VKIGD GLA Sbjct: 472 NNIFLHEGL-TVKIGDFGLA 490
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 54.7 bits (130), Expect = 1e-07 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ L+ E+ +L+ +H NI+ F ++ Sbjct: 362 TVYKG--KWHG-DVAVKILKVVD--PTPEQLQAFRNEVAVLRKTRHVNILLFMGY---MT 413 Query: 210 ARHINFITEMFTSGTLRQYRQ-KHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 ++ +T+ +L ++ + K ++ + D RQ G+ YLH+ N IIHRD+K Sbjct: 414 KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKS 471 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +NIF++ VKIGD GLA Sbjct: 472 NNIFLHEGL-TVKIGDFGLA 490
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 54.7 bits (130), Expect = 1e-07 Identities = 44/140 (31%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + VA +++L P R E+ LLK LKH NI+ + + + Sbjct: 178 TVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR---EVSLLKDLKHANIVTLHD--IIHT 232 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + E + L+QY + N+ VK + Q+L GL Y H ++HRDLK Sbjct: 233 EKSLTLVFE-YLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK--VLHRDLKP 289 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N +GE+K+ D GLA Sbjct: 290 QNLLIN-ERGELKLADFGLA 308
>M4K5_HUMAN (Q9Y4K4) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS) Length = 846 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/138 (29%), Positives = 69/138 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY+A + + G A +KL + DD + EI ++K KH NI+ ++ S+ +S Sbjct: 34 VYKARNVHTGELAAVKIIKL----EPGDDFSLIQQEIFMVKECKHCNIVAYFGSY--LSR 87 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 + E G+L+ ++ + CR+ L GL YLH+ +HRD+K N Sbjct: 88 EKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGAN 145 Query: 393 IFVNGNQGEVKIGDLGLA 446 I + + G+VK+ D G+A Sbjct: 146 ILLT-DHGDVKLADFGVA 162
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 54.7 bits (130), Expect = 1e-07 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ L+ E+ +L+ +H NI+ F ++ Sbjct: 37 TVYKG--KWHG-DVAVKILKVVD--PTPEQLQAFRNEVAVLRKTRHVNILLFMGY---MT 88 Query: 210 ARHINFITEMFTSGTLRQYRQ-KHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 ++ +T+ +L ++ + K ++ + D RQ G+ YLH+ N IIHRD+K Sbjct: 89 KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKS 146 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +NIF++ VKIGD GLA Sbjct: 147 NNIFLHEGL-TVKIGDFGLA 165
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/108 (37%), Positives = 60/108 (55%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R Y E+ LLK L+H+N++ ++ I F+TE+ GT + R + V Sbjct: 65 KRTYRELKLLKHLRHENLICLQDIFLS-PLEDIYFVTEL--QGTDLHRLLQTRPLEKQFV 121 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QIL GL Y+HS +IHRDLK NI +N N ++KI D GLA Sbjct: 122 QYFLYQILRGLKYVHSAG--VIHRDLKPSNILINEN-CDLKICDFGLA 166
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 54.7 bits (130), Expect = 1e-07 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ ++ G VA +++L + P R EI LLK L+H N+++ + S Sbjct: 18 VYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVR---EISLLKELQHPNVVRLLDVLMQES 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+L+ H ++HRDL Sbjct: 75 KLYLVF---EFLSMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCHCRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ N+G +K+ D GLA Sbjct: 130 KPQNLLID-NKGVIKLADFGLA 150
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 54.3 bits (129), Expect = 1e-07 Identities = 36/103 (34%), Positives = 54/103 (52%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E+ LLK LKH NI+ + + + R + + E S + +N+ VK + Sbjct: 167 EVSLLKDLKHANIVTLHD--LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMF 224 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L GL Y H I+HRDLK N+ +N +GE+K+ D GLA Sbjct: 225 QLLRGLAYCHRRK--ILHRDLKPQNLLIN-ERGELKLADFGLA 264
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 54.3 bits (129), Expect = 1e-07 Identities = 36/103 (34%), Positives = 54/103 (52%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E+ LLK LKH NI+ + + + R + + E S + +N+ VK + Sbjct: 167 EVSLLKDLKHANIVTLHD--LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMF 224 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L GL Y H I+HRDLK N+ +N +GE+K+ D GLA Sbjct: 225 QLLRGLAYCHHRK--ILHRDLKPQNLLIN-ERGELKLADFGLA 264
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 54.3 bits (129), Expect = 1e-07 Identities = 39/116 (33%), Positives = 61/116 (52%), Gaps = 5/116 (4%) Frame = +3 Query: 114 DDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINF-----ITEMFTSGTLRQYRQKH 278 +D + Y EI LLK + H+N++ + + + F +T + + R R K Sbjct: 59 EDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSK- 117 Query: 279 RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +++ ++ QIL GL Y+HS ++HRDLK NI VNGN EV+I D GL+ Sbjct: 118 -RMSDQEIRIILYQILRGLKYIHSAG--VVHRDLKPCNIAVNGN-SEVRILDFGLS 169
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 54.3 bits (129), Expect = 1e-07 Identities = 42/141 (29%), Positives = 69/141 (48%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K + Sbjct: 18 VYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDV---IH 71 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWA--VKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + ++ F L+++ + +K + Q+L GL + HSH ++HRDLK Sbjct: 72 TENKLYLVFEFLHQDLKKFMDASALTGLPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N +G +K+ D GLA Sbjct: 130 PQNLLINA-EGSIKLADFGLA 149
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 54.3 bits (129), Expect = 1e-07 Identities = 48/138 (34%), Positives = 71/138 (51%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V A D+ G VA ++ + FL +R Y E+ LLK L+H+N++ ++ Sbjct: 37 VCSAIDKLTGQNVAVKKI-MKPFLTSVL-AKRTYRELKLLKHLRHENLITLDDIFLS-PL 93 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 I F+TE+ GT R + ++ + QIL GL Y+HS +IHRDLK N Sbjct: 94 EDIYFVTEL--QGTDLHRLLTSRPLEKQFIQYFTYQILRGLKYVHSAG--VIHRDLKPSN 149 Query: 393 IFVNGNQGEVKIGDLGLA 446 I +N N ++KI D GLA Sbjct: 150 ILINEN-CDLKICDFGLA 166
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 54.3 bits (129), Expect = 1e-07 Identities = 34/103 (33%), Positives = 55/103 (53%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI LK LKH +I++ + V S IN + E+ T G L + K+ + + Sbjct: 68 EIRTLKMLKHPHIVRLHE--VLASKTKINMVMELVTGGELFDRIVSNGKLTETDGRKMFQ 125 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q++ G+ Y HS + HRDLK +N+ ++ +G +KI D GL+ Sbjct: 126 QLIDGISYCHSKG--VFHRDLKLENVLLDA-KGHIKITDFGLS 165
>KKCC2_RAT (O88831) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 587 Score = 54.3 bits (129), Expect = 1e-07 Identities = 32/109 (29%), Positives = 58/109 (53%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 +E++Y EI +LK L H N++K D + H+ + E+ G + + + ++ Sbjct: 229 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL-KPLSEDQ 287 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + + ++ G+ YLH IIHRD+K N+ V G G +KI D G++ Sbjct: 288 ARFYFQDLIKGIEYLHYQK--IIHRDIKPSNLLV-GEDGHIKIADFGVS 333
>KKCC2_MOUSE (Q8C078) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 54.3 bits (129), Expect = 1e-07 Identities = 32/109 (29%), Positives = 58/109 (53%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 +E++Y EI +LK L H N++K D + H+ + E+ G + + + ++ Sbjct: 230 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL-KPLSEDQ 288 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + + ++ G+ YLH IIHRD+K N+ V G G +KI D G++ Sbjct: 289 ARFYFQDLIKGIEYLHYQK--IIHRDIKPSNLLV-GEDGHIKIADFGVS 334
>KKCC2_HUMAN (Q96RR4) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 54.3 bits (129), Expect = 1e-07 Identities = 32/109 (29%), Positives = 58/109 (53%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 +E++Y EI +LK L H N++K D + H+ + E+ G + + + ++ Sbjct: 230 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL-KPLSEDQ 288 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + + ++ G+ YLH IIHRD+K N+ V G G +KI D G++ Sbjct: 289 ARFYFQDLIKGIEYLHYQK--IIHRDIKPSNLLV-GEDGHIKIADFGVS 334
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 53.9 bits (128), Expect = 2e-07 Identities = 35/108 (32%), Positives = 57/108 (52%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R E L + L H +I + + + + H + E + G L Y +H + Sbjct: 168 KRTVREASLGQILYHPHICRLFE--MCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHA 225 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + R I S L YLH++N I+HRDLK +NI ++ + GE+KI D GL+ Sbjct: 226 RKFARGIASALQYLHANN--IVHRDLKIENIMIS-SSGEIKIIDFGLS 270
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 53.9 bits (128), Expect = 2e-07 Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 2/105 (1%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQK--HRKVNIWAVKDW 311 E +LK L H N++++Y ++++ A I E GTL ++ QK + + + + Sbjct: 51 ECQVLKLLNHPNVIEYYENFLEDKALMIAM--EYAPGGTLAEFIQKRCNSLLEEETILHF 108 Query: 312 CRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QIL L ++H+H I+HRDLK NI ++ ++ VKIGD G++ Sbjct: 109 FVQILLALHHVHTHL--ILHRDLKTQNILLDKHRMVVKIGDFGIS 151
>TLK2_HUMAN (Q86UE8) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) (PKU-alpha) Length = 772 Score = 53.9 bits (128), Expect = 2e-07 Identities = 45/143 (31%), Positives = 70/143 (48%), Gaps = 5/143 (3%) Frame = +3 Query: 33 VYRAFD--EYQGMEVAWNQVKLYDFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVD 203 VY+AFD E + + V +Q+ + ++ + C E + K L H I+K Y + Sbjct: 476 VYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLY-DYFS 534 Query: 204 VSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E L Y ++H+ ++ + QI++ L YL+ PPIIH DLK Sbjct: 535 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 594 Query: 384 CDNI-FVNGNQ-GEVKIGDLGLA 446 NI VNG GE+KI D GL+ Sbjct: 595 PGNILLVNGTACGEIKITDFGLS 617
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/108 (36%), Positives = 58/108 (53%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R Y E+ LLK LKH+N++ ++ I F+ E+ GT R + + Sbjct: 65 KRTYRELKLLKHLKHENLITLDDIFIS-PLEDIYFVNEL--QGTDLHRLLNSRPLEKQFI 121 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QI+ GL Y+HS +IHRDLK NI +N N ++KI D GLA Sbjct: 122 QYFTYQIMRGLKYIHSAG--VIHRDLKPSNILINEN-CDLKICDFGLA 166
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/107 (33%), Positives = 58/107 (54%) Frame = +3 Query: 126 RLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVK 305 +L+ EI + +++ H NI+ F + D + +I I E+ +L + +K +++ V+ Sbjct: 84 KLFGEIKVHQSMSHPNIVGFIDCFED--STNIYLILELCEHKSLMELLRKRKQLTEPEVR 141 Query: 306 DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QIL L Y+H +IHRDLK NI ++ VKIGD GLA Sbjct: 142 YLMMQILGALKYMHKKR--VIHRDLKLGNIMLD-ESNNVKIGDFGLA 185
>TLK2_MOUSE (O55047) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) Length = 718 Score = 53.9 bits (128), Expect = 2e-07 Identities = 45/143 (31%), Positives = 70/143 (48%), Gaps = 5/143 (3%) Frame = +3 Query: 33 VYRAFD--EYQGMEVAWNQVKLYDFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVD 203 VY+AFD E + + V +Q+ + ++ + C E + K L H I+K Y + Sbjct: 422 VYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLY-DYFS 480 Query: 204 VSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E L Y ++H+ ++ + QI++ L YL+ PPIIH DLK Sbjct: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540 Query: 384 CDNI-FVNGNQ-GEVKIGDLGLA 446 NI VNG GE+KI D GL+ Sbjct: 541 PGNILLVNGTACGEIKITDFGLS 563
>NEK2_HUMAN (P51955) Serine/threonine-protein kinase Nek2 (EC 2.7.11.1)| (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) Length = 445 Score = 53.9 bits (128), Expect = 2e-07 Identities = 34/115 (29%), Positives = 60/115 (52%), Gaps = 7/115 (6%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 + L E++LL+ LKH NI+++Y +D + + + E G L K K + Sbjct: 50 QMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLD 109 Query: 303 KDWCRQILS----GLLYLHSHNP---PIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +++ ++++ L H + ++HRDLK N+F++G Q VK+GD GLA Sbjct: 110 EEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQ-NVKLGDFGLA 163
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/101 (38%), Positives = 49/101 (48%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 +I L+ LKH NI+ F V A I E G L + + RK+ + DW Sbjct: 204 DIKHLRKLKHPNIIAF--KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWST 261 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 I SG+ YLH H IIHRDLK N+ V + VKI D G Sbjct: 262 GIASGMNYLHLHK--IIHRDLKSPNVLVT-HTDAVKISDFG 299
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/101 (38%), Positives = 49/101 (48%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 +I L+ LKH NI+ F V A I E G L + + RK+ + DW Sbjct: 204 DIKHLRKLKHPNIIAF--KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWST 261 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 I SG+ YLH H IIHRDLK N+ V + VKI D G Sbjct: 262 GIASGMNYLHLHK--IIHRDLKSPNVLVT-HTDAVKISDFG 299
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 53.9 bits (128), Expect = 2e-07 Identities = 34/108 (31%), Positives = 57/108 (52%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R E L + L H +I + + + + H + E + G L Y +H + Sbjct: 189 KRTIREASLGQILYHPHICRLFE--MCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQA 246 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + R I S L+YLH++N I+HRDLK +NI ++ + E+KI D GL+ Sbjct: 247 RKFARGIASALIYLHANN--IVHRDLKIENIMIS-DSSEIKIIDFGLS 291
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 53.9 bits (128), Expect = 2e-07 Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 2/105 (1%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQK--HRKVNIWAVKDW 311 E +LK L H N++++Y ++++ A I E GTL ++ QK + + + + Sbjct: 51 ECQVLKLLNHPNVIEYYENFLEDKALMIAM--EYAPGGTLAEFIQKRCNSLLEEETILHF 108 Query: 312 CRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QIL L ++H+H I+HRDLK NI ++ ++ VKIGD G++ Sbjct: 109 FVQILLALHHVHTHL--ILHRDLKTQNILLDKHRMVVKIGDFGIS 151
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 53.9 bits (128), Expect = 2e-07 Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 3/104 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR--KVNIWAVKDW 311 E +L L H+NI++FY V + + +TE + G+L Y +R ++++ + W Sbjct: 53 EAEILSVLSHRNIIQFY--GVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTW 110 Query: 312 CRQILSGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + G+ YLH P +IHRDLK N+ + + G +KI D G Sbjct: 111 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAAD-GVLKICDFG 153
>CDK4_RAT (P35426) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 53.5 bits (127), Expect = 2e-07 Identities = 49/149 (32%), Positives = 72/149 (48%), Gaps = 10/149 (6%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQC----PDDLERLYCEIHLLKTLKHKNIMKFY--- 188 TVY+A D + G VA V++ + P R + L+ +H N+++ Sbjct: 19 TVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVC 78 Query: 189 -TSWVDVSARHINFITEMFTSGTLRQYRQKHRK--VNIWAVKDWCRQILSGLLYLHSHNP 359 TS D + + + E LR Y K + + +KD RQ LSGL +LH++ Sbjct: 79 ATSRTDRDIK-VTLVFEHIDQD-LRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANC- 135 Query: 360 PIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 I+HRDLK +NI V N G VK+ D GLA Sbjct: 136 -IVHRDLKPENILVTSN-GTVKLADFGLA 162
>CDK4_MOUSE (P30285) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) (CRK3) Length = 303 Score = 53.5 bits (127), Expect = 2e-07 Identities = 49/149 (32%), Positives = 72/149 (48%), Gaps = 10/149 (6%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQC----PDDLERLYCEIHLLKTLKHKNIMKFY--- 188 TVY+A D + G VA V++ + P R + L+ +H N+++ Sbjct: 19 TVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVC 78 Query: 189 -TSWVDVSARHINFITEMFTSGTLRQYRQKHRK--VNIWAVKDWCRQILSGLLYLHSHNP 359 TS D + + + E LR Y K + + +KD RQ LSGL +LH++ Sbjct: 79 ATSRTDRDIK-VTLVFEHIDQD-LRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANC- 135 Query: 360 PIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 I+HRDLK +NI V N G VK+ D GLA Sbjct: 136 -IVHRDLKPENILVTSN-GTVKLADFGLA 162
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 53.5 bits (127), Expect = 2e-07 Identities = 40/108 (37%), Positives = 60/108 (55%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R Y E+ LLK L+H+N++ ++ I F+TE+ GT + R + V Sbjct: 65 KRTYRELKLLKHLRHENLICLQDIFLS-PLEDIYFVTEL--QGTDLHRLLQTRPLEKQFV 121 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QIL GL Y+HS ++HRDLK NI +N N ++KI D GLA Sbjct: 122 QYFHYQILRGLKYVHSAG--VVHRDLKPSNILINEN-CDLKICDFGLA 166
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 53.5 bits (127), Expect = 2e-07 Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 4/135 (2%) Frame = +3 Query: 54 YQGMEVAWNQVKLYDFLQ--CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINF 227 +Q E+A VK++DFL+ + ER EI L + H+N+++ + ++ Sbjct: 30 FQNQEIA---VKIFDFLEETIKKNAER---EITHLSEIDHENVIRVIGRASNGKKDYL-- 81 Query: 228 ITEMFTSGTLRQYRQKHRK--VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFV 401 + E G+L Y K + W Q L YLHS + PI+HRD+K N+ + Sbjct: 82 LMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRDIKPQNMLL 141 Query: 402 NGNQGEVKIGDLGLA 446 ++KI D GLA Sbjct: 142 YNQHEDLKICDFGLA 156
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 53.5 bits (127), Expect = 2e-07 Identities = 44/140 (31%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + VA +++L P R E+ LLK LKH NI+ + + + Sbjct: 205 TVYKGRSKLTENLVALKEIRLEHEEGAPCTAIR---EVSLLKDLKHANIVTLHD--IVHT 259 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + E + L+QY + ++ VK + QIL GL Y H ++HRDLK Sbjct: 260 DKSLTLVFE-YLDKDLKQYMDDCGSIMSMHNVKLFLYQILRGLAYCHRRK--VLHRDLKP 316 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N +GE+K+ D GLA Sbjct: 317 QNLLIN-ERGELKLADFGLA 335
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 53.5 bits (127), Expect = 2e-07 Identities = 44/140 (31%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + VA +++L P R E+ LLK LKH NI+ + + + Sbjct: 205 TVYKGRSKLTENLVALKEIRLEHEEGAPCTAIR---EVSLLKDLKHANIVTLHD--IVHT 259 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + E + L+QY + ++ VK + QIL GL Y H ++HRDLK Sbjct: 260 DKSLTLVFE-YLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK--VLHRDLKP 316 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N +GE+K+ D GLA Sbjct: 317 QNLLIN-ERGELKLADFGLA 335
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 53.5 bits (127), Expect = 2e-07 Identities = 44/140 (31%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + VA +++L P R E+ LLK LKH NI+ + + + Sbjct: 205 TVYKGRSKLTENLVALKEIRLEHEEGAPCTAIR---EVSLLKDLKHANIVTLHD--IVHT 259 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV-NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + E + L+QY + ++ VK + QIL GL Y H ++HRDLK Sbjct: 260 DKSLTLVFE-YLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK--VLHRDLKP 316 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ +N +GE+K+ D GLA Sbjct: 317 QNLLIN-EKGELKLADFGLA 335
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 53.5 bits (127), Expect = 2e-07 Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 3/104 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR--KVNIWAVKDW 311 E +L L H+NI++FY V + + +TE + G+L Y +R ++++ + W Sbjct: 53 EAEILSVLSHRNIIQFY--GVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTW 110 Query: 312 CRQILSGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + G+ YLH P +IHRDLK N+ + + G +KI D G Sbjct: 111 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAAD-GVLKICDFG 153
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 53.5 bits (127), Expect = 2e-07 Identities = 31/103 (30%), Positives = 59/103 (57%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK ++H +++K + V + +++ + E + G L Y K ++ + + R Sbjct: 66 EIAILKLIEHPHVLKLHD--VYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFR 123 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 QI+S L + HSH+ I HRDLK +N+ ++ + ++I D G+A Sbjct: 124 QIISALDFCHSHS--ICHRDLKPENLLLD-EKNNIRIADFGMA 163
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 53.5 bits (127), Expect = 2e-07 Identities = 37/119 (31%), Positives = 64/119 (53%), Gaps = 2/119 (1%) Frame = +3 Query: 96 DFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQ 272 + ++ ++ +R + E+ +++ L+H +++KF V + +NFITE GTLR+ + Sbjct: 344 ELIRFDEETQRTFLKEVKVMRCLEHPHVLKFIG--VLYKDKRLNFITEYIPGGTLRRVIK 401 Query: 273 KHRKVNIWAVK-DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W + + R I +G+ YLHS N IIHRDL N V + G V + + GL+ Sbjct: 402 SMDTHCPWNQRVSFARDIAAGMTYLHSMN--IIHRDLNSHNCLVREDGGLV-VANFGLS 457
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 53.5 bits (127), Expect = 2e-07 Identities = 34/103 (33%), Positives = 52/103 (50%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK LKH NI+K Y V + + + + E + + K + Sbjct: 50 EISILKELKHSNIVKLYD--VIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLL 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L+G+ Y H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 108 QLLNGIAYCHDRR--VLHRDLKPQNLLIN-REGELKIADFGLA 147
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 53.5 bits (127), Expect = 2e-07 Identities = 34/103 (33%), Positives = 52/103 (50%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK LKH NI+K Y V + + + + E + + K + Sbjct: 50 EISILKELKHSNIVKLYD--VIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLL 107 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L+G+ Y H ++HRDLK N+ +N +GE+KI D GLA Sbjct: 108 QLLNGIAYCHDRR--VLHRDLKPQNLLIN-REGELKIADFGLA 147
>KKCC1_HUMAN (Q8N5S9) Calcium/calmodulin-dependent protein kinase kinase 1 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase) Length = 505 Score = 53.5 bits (127), Expect = 2e-07 Identities = 33/109 (30%), Positives = 58/109 (53%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 LER+Y EI +LK L H N++K D + ++ + ++ G + + + + Sbjct: 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV-PCDKPFSEEQ 251 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + R ++ GL YLH I+HRD+K N+ + G+ G VKI D G++ Sbjct: 252 ARLYLRDVILGLEYLHCQK--IVHRDIKPSNLLL-GDDGHVKIADFGVS 297
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 53.5 bits (127), Expect = 2e-07 Identities = 49/142 (34%), Positives = 72/142 (50%), Gaps = 3/142 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNI---MKFYTSWV 200 TV A D G +VA KL+ Q +R Y E+ LLK +KH N+ + +T+ + Sbjct: 38 TVCYALDRRTGAKVAIK--KLHRPFQSDLFAKRAYRELRLLKHMKHDNVIGLVDVFTADL 95 Query: 201 DVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 + H +F M GT K +++ V+ Q+L GL Y+H+ IIHRDL Sbjct: 96 SLDRFH-DFYLVMPFMGTDLGKLMKMERLSEERVQYLVYQMLKGLKYIHAAG--IIHRDL 152 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ +N + E+KI D GLA Sbjct: 153 KPGNLAIN-EECELKILDFGLA 173
>TSSK6_HUMAN (Q9BXA6) Testis-specific serine/threonine-protein kinase 6 (EC| 2.7.11.1) (TSSK-6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK) Length = 273 Score = 53.5 bits (127), Expect = 2e-07 Identities = 31/121 (25%), Positives = 65/121 (53%), Gaps = 2/121 (1%) Frame = +3 Query: 84 VKLYDFLQCPDDLERLYC--EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTL 257 +K+ D + P D + E+ +L+ ++H +I+ + +++V + + E + L Sbjct: 40 IKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVF-EFIEVCNGKLYIVMEAAATDLL 98 Query: 258 RQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDL 437 + ++ R + A +D QI + YLH H+ ++HRDLKC+N+ ++ ++ VK+ D Sbjct: 99 QAVQRNGRIPGVQA-RDLFAQIAGAVRYLHDHH--LVHRDLKCENVLLSPDERRVKLTDF 155 Query: 438 G 440 G Sbjct: 156 G 156
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 53.5 bits (127), Expect = 2e-07 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + + P R EI LLK L+H NI+ + S Sbjct: 18 VYKGRHKATGQVVAMKKIRLENEEEGVPSTAIR---EISLLKELQHPNIVCLLDVLMQDS 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S +++Y + ++ VK + QIL G+++ HS ++HRDL Sbjct: 75 RLYLIF---EFLSMDVKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRG--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ N+G +K+ D GLA Sbjct: 130 KPQNLLID-NKGVIKLADFGLA 150
>TLK1_MOUSE (Q8C0V0) Serine/threonine-protein kinase tousled-like 1 (EC| 2.7.11.1) (Tousled-like kinase 1) Length = 766 Score = 53.5 bits (127), Expect = 2e-07 Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 8/146 (5%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQC-----PDDLERLYC-EIHLLKTLKHKNIMKFYTS 194 VY+AFD Y+ A VK++ + ++ + C E + K L H I+K Y Sbjct: 470 VYKAFDLYEQRYAA---VKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLY-D 525 Query: 195 WVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHR 374 + + + E L Y ++H+ ++ + QI++ L YL+ PPIIH Sbjct: 526 YFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHY 585 Query: 375 DLKCDNI-FVNGNQ-GEVKIGDLGLA 446 DLK NI V+G GE+KI D GL+ Sbjct: 586 DLKPGNILLVDGTACGEIKITDFGLS 611
>TLK1_HUMAN (Q9UKI8) Serine/threonine-protein kinase tousled-like 1 (EC| 2.7.11.1) (Tousled-like kinase 1) (PKU-beta) Length = 766 Score = 53.5 bits (127), Expect = 2e-07 Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 8/146 (5%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQC-----PDDLERLYC-EIHLLKTLKHKNIMKFYTS 194 VY+AFD Y+ A VK++ + ++ + C E + K L H I+K Y Sbjct: 470 VYKAFDLYEQRYAA---VKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLY-D 525 Query: 195 WVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHR 374 + + + E L Y ++H+ ++ + QI++ L YL+ PPIIH Sbjct: 526 YFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHY 585 Query: 375 DLKCDNI-FVNGNQ-GEVKIGDLGLA 446 DLK NI V+G GE+KI D GL+ Sbjct: 586 DLKPGNILLVDGTACGEIKITDFGLS 611
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 53.1 bits (126), Expect = 3e-07 Identities = 36/107 (33%), Positives = 58/107 (54%), Gaps = 1/107 (0%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHR-KVNIWA 299 E + EI ++K +HKNI+ F S++ + + I E G+L + + + K+N Sbjct: 721 ELIINEILVMKDSQHKNIVNFLDSYL-IGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQ 779 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 + C + L GL +LH + IIHRD+K DN+ ++ G VKI D G Sbjct: 780 IATICFETLKGLQHLHKKH--IIHRDIKSDNVLLDA-YGNVKITDFG 823
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 53.1 bits (126), Expect = 3e-07 Identities = 40/108 (37%), Positives = 60/108 (55%) Frame = +3 Query: 123 ERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAV 302 +R Y E+ LLK L+H+N++ ++ I F+TE+ GT + R + + Sbjct: 65 KRTYRELKLLKHLRHENLICLEDIFLS-PLEDIYFVTEL--QGTDLHRLLQTRPLEKQFL 121 Query: 303 KDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + QIL GL Y+HS +IHRDLK NI +N N ++KI D GLA Sbjct: 122 QYFLYQILRGLKYVHSAG--VIHRDLKPSNILINEN-CDLKICDFGLA 166
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 53.1 bits (126), Expect = 3e-07 Identities = 44/141 (31%), Positives = 70/141 (49%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A ++ G VA +++L + P R EI LLK L H NI+K V + Sbjct: 18 VYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLD--VIHT 72 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWA--VKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + E+ L+++ I +K + Q+L GL + HSH ++HRDLK Sbjct: 73 ENKLYLVFELLHQD-LKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ +N +G +K+ D GLA Sbjct: 130 PQNLLINA-EGSIKLADFGLA 149
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 53.1 bits (126), Expect = 3e-07 Identities = 43/140 (30%), Positives = 75/140 (53%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ + E+ +L+ +H NI+ F ++ Sbjct: 362 TVYKG--KWHG-DVAVKILKVVD--PTPEQFQAFRNEVAVLRKTRHVNILLFMGY---MT 413 Query: 210 ARHINFITEMFTSGTLRQYRQ-KHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 ++ +T+ +L ++ + K ++ + D RQ G+ YLH+ N IIHRD+K Sbjct: 414 KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKS 471 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +NIF++ VKIGD GLA Sbjct: 472 NNIFLHEGL-TVKIGDFGLA 490
>MK12_HUMAN (P53778) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 53.1 bits (126), Expect = 3e-07 Identities = 48/140 (34%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWV--DV 206 V A D G +VA KLY Q +R Y E+ LLK ++H+N++ + + Sbjct: 41 VCSAVDGRTGAKVAIK--KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDET 98 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 +F M GT KH K+ ++ Q+L GL Y+H+ IIHRDLK Sbjct: 99 LDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG--IIHRDLKP 156 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ VN E+KI D GLA Sbjct: 157 GNLAVN-EDCELKILDFGLA 175
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 53.1 bits (126), Expect = 3e-07 Identities = 42/141 (29%), Positives = 70/141 (49%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A D+ +A +++L + P R EI LLK + H NI++ + V S Sbjct: 18 VYKALDKATNETIALKKIRLEQEDEGVPSTAIR---EISLLKEMNHGNIVRLHD--VVHS 72 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV--NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + I + E + L+++ + N +K + QIL G+ Y HSH ++HRDLK Sbjct: 73 EKRIYLVFE-YLDLDLKKFMDSCPEFAKNPTLIKSYLYQILHGVAYCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ ++ +K+ D GLA Sbjct: 130 PQNLLIDRRTNALKLADFGLA 150
>CDC21_ORYSA (P29618) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 294 Score = 53.1 bits (126), Expect = 3e-07 Identities = 43/141 (30%), Positives = 70/141 (49%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VYRA D+ +A +++L + P R EI LLK + H NI++ + V S Sbjct: 18 VYRARDKVTNETIALKKIRLEQEDEGVPSTAIR---EISLLKEMHHGNIVRLHD--VIHS 72 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKV--NIWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + I + E + L+++ + N +K + QIL G+ Y HSH ++HRDLK Sbjct: 73 EKRIYLVFE-YLDLDLKKFMDSCPEFAKNPTLIKSYLYQILRGVAYCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ ++ +K+ D GLA Sbjct: 130 PQNLLIDRRTNALKLADFGLA 150
>NEK11_HUMAN (Q8NG66) Serine/threonine-protein kinase Nek11 (EC 2.7.11.1)| (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11) Length = 645 Score = 53.1 bits (126), Expect = 3e-07 Identities = 37/116 (31%), Positives = 60/116 (51%), Gaps = 4/116 (3%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTL----RQYRQKH 278 P++ + E LL L H I+KF+ S+V+ + ITE L ++Y+Q Sbjct: 70 PNETVQANLEAQLLSKLDHPAIVKFHASFVEQD--NFCIITEYCEGRDLDDKIQEYKQAG 127 Query: 279 RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + +W Q+L G+ Y+H I+HRDLK N+F+ N +KIGD G++ Sbjct: 128 KIFPENQIIEWFIQLLLGVDYMHERR--ILHRDLKSKNVFLKNNL--LKIGDFGVS 179
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 53.1 bits (126), Expect = 3e-07 Identities = 38/130 (29%), Positives = 66/130 (50%), Gaps = 1/130 (0%) Frame = +3 Query: 60 GMEVAWNQVKLYDFLQC-PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITE 236 G EVA VK+ D Q L++L+ E+ ++K L H NI+K + V + + + + E Sbjct: 76 GKEVA---VKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE--VIETEKTLYLVME 130 Query: 237 MFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQG 416 + G + Y H ++ + RQI+ + Y H I+HRDLK +N+ ++ + Sbjct: 131 YASGGEVFDYLVAHGRMKEKEARAKFRQIVLHVQYCHQKF--IVHRDLKAENLLLDADM- 187 Query: 417 EVKIGDLGLA 446 +KI D G + Sbjct: 188 NIKIADFGFS 197
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 53.1 bits (126), Expect = 3e-07 Identities = 43/140 (30%), Positives = 75/140 (53%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ + E+ +L+ +H NI+ F ++ Sbjct: 362 TVYKG--KWHG-DVAVKILKVVD--PTPEQFQAFRNEVAVLRKTRHVNILLFMGY---MT 413 Query: 210 ARHINFITEMFTSGTLRQYRQ-KHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 ++ +T+ +L ++ + K ++ + D RQ G+ YLH+ N IIHRD+K Sbjct: 414 KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKS 471 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +NIF++ VKIGD GLA Sbjct: 472 NNIFLHEGL-TVKIGDFGLA 490
>PLK1_CAEEL (P34331) Serine/threonine-protein kinase plk-1 (EC 2.7.11.21)| (Polo-like kinase 1) Length = 649 Score = 52.8 bits (125), Expect = 4e-07 Identities = 35/98 (35%), Positives = 54/98 (55%) Frame = +3 Query: 153 KTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSG 332 + L H NI+K + + D +I E+ +L + ++ + V + + QI+ G Sbjct: 92 RELGHINIVKLFNFFEDNLNVYITL--ELCARRSLMELHKRRKAVTEPEARYFTHQIVDG 149 Query: 333 LLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +LYLH N IIHRD+K N+F+N + VKIGD GLA Sbjct: 150 VLYLHDLN--IIHRDMKLGNLFLNDDL-VVKIGDFGLA 184
>MK14_PANTR (Q95NE7) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) Length = 359 Score = 52.8 bits (125), Expect = 4e-07 Identities = 51/143 (35%), Positives = 70/143 (48%), Gaps = 4/143 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 +V AFD G+ VA KL Q +R Y E+ LLK +KH+N++ V Sbjct: 36 SVCAAFDTKTGLRVAVK--KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD--VFTP 91 Query: 210 ARHINFITEMFT----SGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRD 377 AR + +++ G K +K+ V+ QIL GL Y+HS + IIHRD Sbjct: 92 ARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD--IIHRD 149 Query: 378 LKCDNIFVNGNQGEVKIGDLGLA 446 LK N+ VN E+KI D GLA Sbjct: 150 LKPSNLAVN-EDCELKILDFGLA 171
>MK14_HUMAN (Q16539) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting prote Length = 359 Score = 52.8 bits (125), Expect = 4e-07 Identities = 51/143 (35%), Positives = 70/143 (48%), Gaps = 4/143 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 +V AFD G+ VA KL Q +R Y E+ LLK +KH+N++ V Sbjct: 36 SVCAAFDTKTGLRVAVK--KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD--VFTP 91 Query: 210 ARHINFITEMFT----SGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRD 377 AR + +++ G K +K+ V+ QIL GL Y+HS + IIHRD Sbjct: 92 ARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD--IIHRD 149 Query: 378 LKCDNIFVNGNQGEVKIGDLGLA 446 LK N+ VN E+KI D GLA Sbjct: 150 LKPSNLAVN-EDCELKILDFGLA 171
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Length = 359 Score = 52.8 bits (125), Expect = 4e-07 Identities = 51/143 (35%), Positives = 70/143 (48%), Gaps = 4/143 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 +V AFD G+ VA KL Q +R Y E+ LLK +KH+N++ V Sbjct: 36 SVCAAFDTKTGLRVAVK--KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD--VFTP 91 Query: 210 ARHINFITEMFT----SGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRD 377 AR + +++ G K +K+ V+ QIL GL Y+HS + IIHRD Sbjct: 92 ARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD--IIHRD 149 Query: 378 LKCDNIFVNGNQGEVKIGDLGLA 446 LK N+ VN E+KI D GLA Sbjct: 150 LKPSNLAVN-EDCELKILDFGLA 171
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 52.8 bits (125), Expect = 4e-07 Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDV 206 TVY+A D+ VA ++KL + D + R EI LL+ L H NI+ ++ Sbjct: 25 TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK 84 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S +I+ + + + + + +K + L GL YLH H I+HRDLK Sbjct: 85 S--NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW--ILHRDLKP 140 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +N+ ++ N G +K+ D GLA Sbjct: 141 NNLLLDEN-GVLKLADFGLA 159
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 52.8 bits (125), Expect = 4e-07 Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDV 206 TVY+A D+ VA ++KL + D + R EI LL+ L H NI+ ++ Sbjct: 25 TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK 84 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S +I+ + + + + + +K + L GL YLH H I+HRDLK Sbjct: 85 S--NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW--ILHRDLKP 140 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +N+ ++ N G +K+ D GLA Sbjct: 141 NNLLLDEN-GVLKLADFGLA 159
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 52.8 bits (125), Expect = 4e-07 Identities = 33/103 (32%), Positives = 58/103 (56%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E +LK ++H +++ + ++ D AR+I + + G L +K ++ K + Sbjct: 118 ERRMLKLVEHPFLIRMWGTFQD--ARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAA 175 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +++ L YLH+HN II+RDLK +NI ++ N G +KI D G A Sbjct: 176 EVILALEYLHAHN--IIYRDLKPENILLDRN-GHIKITDFGFA 215
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 52.8 bits (125), Expect = 4e-07 Identities = 46/142 (32%), Positives = 75/142 (52%), Gaps = 3/142 (2%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ ++ G +VA +K+ D P+ L+ E+ +L+ +H NI+ F ++ Sbjct: 353 TVYKG--KWHG-DVAVKILKVTD--PTPEQLQAFRNEVAVLRKTRHVNILLFMGY---MT 404 Query: 210 ARHINFITEMFTSGTLRQYRQKH---RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ +T+ +L Y H K ++ + D RQ G+ YLH+ N IIHRD+ Sbjct: 405 KDNLAIVTQWCEGSSL--YYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDM 460 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K +NIF++ VKIGD GLA Sbjct: 461 KSNNIFLHEGL-TVKIGDFGLA 481
>MMK2_MEDSA (Q40353) Mitogen-activated protein kinase homolog MMK2 (EC| 2.7.11.24) Length = 371 Score = 52.8 bits (125), Expect = 4e-07 Identities = 40/121 (33%), Positives = 62/121 (51%), Gaps = 11/121 (9%) Frame = +3 Query: 117 DLERLYCEIHLLKTLKHKNIMKFYTSWVDV-------SARHINFITEMFTSGTLRQYRQK 275 D +R EI LL+ + H+N+M S D+ + H+ ++E+ + + R Sbjct: 77 DAKRTLREIKLLRHMDHENVM----SIKDIIRPPQKENFNHVYIVSELMDTDLHQIIRSN 132 Query: 276 HRKVNIWAVKDWCR----QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGL 443 + D CR Q+L GL Y+HS N ++HRDLK N+ +N N ++KIGD GL Sbjct: 133 QPMTD-----DHCRYFVYQLLRGLKYVHSAN--VLHRDLKPSNLLLNAN-CDLKIGDFGL 184 Query: 444 A 446 A Sbjct: 185 A 185
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 52.8 bits (125), Expect = 4e-07 Identities = 42/140 (30%), Positives = 69/140 (49%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV +A + G A VK+ + +++ + E+ +L+ L H I++ + D Sbjct: 211 TVKKAIERTTGKTFA---VKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTE 267 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + ++ + E + G L + H V A ++ RQIL+ + Y+HS I HRDLK D Sbjct: 268 SYYM--VMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMG--ISHRDLKPD 323 Query: 390 NIFVNGNQGE-VKIGDLGLA 446 NI + + VKI D GLA Sbjct: 324 NILIEQDDPVLVKITDFGLA 343
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 52.8 bits (125), Expect = 4e-07 Identities = 43/137 (31%), Positives = 69/137 (50%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TV A D+ G +VA VK D L+ E L+ E+ +++ H NI++ Y+S++ Sbjct: 381 TVCIATDKSTGRQVA---VKKMD-LRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVND 436 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E G L H +++ + C+Q L L YLHS +IHRD+K D Sbjct: 437 ELWV--VMEYLEGGALTDI-VTHSRMDEEQIATVCKQCLKALAYLHSQG--VIHRDIKSD 491 Query: 390 NIFVNGNQGEVKIGDLG 440 +I + + G VK+ D G Sbjct: 492 SILLAAD-GRVKLSDFG 507
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 52.8 bits (125), Expect = 4e-07 Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYC-EIHLLKTLKHKNIMKFYTSWVDV 206 TVY+A D+ VA ++KL + D + R EI LL+ L H NI+ ++ Sbjct: 17 TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK 76 Query: 207 SARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 S +I+ + + + + + +K + L GL YLH H I+HRDLK Sbjct: 77 S--NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW--ILHRDLKP 132 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 +N+ ++ N G +K+ D GLA Sbjct: 133 NNLLLDEN-GVLKLADFGLA 151
>NEK3_MOUSE (Q9R0A5) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) Length = 511 Score = 52.8 bits (125), Expect = 4e-07 Identities = 36/106 (33%), Positives = 58/106 (54%), Gaps = 3/106 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIW---AVKD 308 E LL +KH NI+ F S+ + ++ + E G L Q R K +K N++ + + Sbjct: 48 EAVLLAKMKHPNIVAFKESFE--AEGYLYIVMEYCDGGDLMQ-RIKQQKGNLFPEDTILN 104 Query: 309 WCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W QI G+ ++H ++HRD+K N+F+ N G+VK+GD G A Sbjct: 105 WFIQICLGVNHIHKRR--VLHRDIKSKNVFLTHN-GKVKLGDFGSA 147
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 52.8 bits (125), Expect = 4e-07 Identities = 45/158 (28%), Positives = 74/158 (46%), Gaps = 19/158 (12%) Frame = +3 Query: 24 PXTVYRAF---------DEYQGMEVAWN---QVKLYDFLQCPDDLERLYCEIHLLKTLKH 167 P +YR F D Y +V N +K + Q P E + EI ++K+ H Sbjct: 382 PTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKK-EFIVNEILVMKSHHH 440 Query: 168 KNIMKFYTS-------WVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQIL 326 KNI+ F + W+ + +TE+ T+ TL + + + C++ L Sbjct: 441 KNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQ----------IAAICKETL 490 Query: 327 SGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 GL +LH + I+HRD+K DNI ++ QG++K+ D G Sbjct: 491 EGLQHLHENG--IVHRDIKSDNILLS-LQGDIKLTDFG 525
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 52.8 bits (125), Expect = 4e-07 Identities = 32/101 (31%), Positives = 53/101 (52%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E+ + L+H+NI++ Y + D + I I E G L + Q+H+K++ + Sbjct: 64 EVEIQAHLQHRNILRLYNYFYDDT--RIYLILEYAPGGELYKELQRHQKLDQQRTATIIQ 121 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 ++ L Y H +IHRD+K +N+ + G GEVKI D G Sbjct: 122 ELSDALTYCHEKK--VIHRDIKPENLLL-GLNGEVKISDFG 159
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 52.8 bits (125), Expect = 4e-07 Identities = 35/103 (33%), Positives = 54/103 (52%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E+ LLK LKH NI+ + + + R + + E S + +++ VK + Sbjct: 188 EVSLLKNLKHANIVTLHD--LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMF 245 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L GL Y H I+HRDLK N+ +N +GE+K+ D GLA Sbjct: 246 QLLRGLAYCHHRK--ILHRDLKPQNLLIN-ERGELKLADFGLA 285
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 52.8 bits (125), Expect = 4e-07 Identities = 35/103 (33%), Positives = 54/103 (52%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 E+ LLK LKH NI+ + + + R + + E S + +++ VK + Sbjct: 188 EVSLLKNLKHANIVTLHD--LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMF 245 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 Q+L GL Y H I+HRDLK N+ +N +GE+K+ D GLA Sbjct: 246 QLLRGLAYCHHRK--ILHRDLKPQNLLIN-ERGELKLADFGLA 285
>KKCC1_RAT (P97756) Calcium/calmodulin-dependent protein kinase kinase 1 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (alpha CaMKK) (CaMKK 1) (CaM-kinase IV kinase) Length = 505 Score = 52.8 bits (125), Expect = 4e-07 Identities = 34/109 (31%), Positives = 57/109 (52%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 LER+Y EI +LK L H N++K D + ++ + ++ G + + + Sbjct: 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQ 251 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + R I+ GL YLH I+HRD+K N+ + G+ G VKI D G++ Sbjct: 252 ARLYLRDIILGLEYLHCQK--IVHRDIKPSNLLL-GDDGHVKIADFGVS 297
>KKCC1_MOUSE (Q8VBY2) Calcium/calmodulin-dependent protein kinase kinase 1 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase) Length = 505 Score = 52.8 bits (125), Expect = 4e-07 Identities = 34/109 (31%), Positives = 57/109 (52%) Frame = +3 Query: 120 LERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA 299 LER+Y EI +LK L H N++K D + ++ + ++ G + + + Sbjct: 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQ 251 Query: 300 VKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + R I+ GL YLH I+HRD+K N+ + G+ G VKI D G++ Sbjct: 252 ARLYLRDIILGLEYLHCQK--IVHRDIKPSNLLL-GDDGHVKIADFGVS 297
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 52.8 bits (125), Expect = 4e-07 Identities = 43/136 (31%), Positives = 68/136 (50%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY A++ + VA Q+ L + E + EI ++K KH NI+ F S+V Sbjct: 634 VYTAYEIGTNVSVAIKQMNL----EKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGD 689 Query: 213 RHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDN 392 + I E G+L H + + CR+ LSGL +LHS ++HRD+K DN Sbjct: 690 LWV--IMEYMEGGSLTDV-VTHCILTEGQIGAVCRETLSGLEFLHSKG--VLHRDIKSDN 744 Query: 393 IFVNGNQGEVKIGDLG 440 I ++ +G++K+ D G Sbjct: 745 ILLS-MEGDIKLTDFG 759
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 52.8 bits (125), Expect = 4e-07 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + + P R EI LLK L+H NI+ + S Sbjct: 18 VYKGRHKATGQVVAMKKIRLENEEEGVPSTAIR---EISLLKELQHPNIVCLLDVLMQDS 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+++ HS ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ ++G +K+ D GLA Sbjct: 130 KPQNLLID-SKGVIKLADFGLA 150
>NEK11_MACFA (Q8WNU8) Serine/threonine-protein kinase Nek11 (EC 2.7.11.1)| (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11) Length = 637 Score = 52.4 bits (124), Expect = 5e-07 Identities = 37/116 (31%), Positives = 60/116 (51%), Gaps = 4/116 (3%) Frame = +3 Query: 111 PDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTL----RQYRQKH 278 P++ + E LL L H I+KF+ S+V+ + ITE L ++Y++ Sbjct: 70 PNETVQANLEAQLLSKLDHPAIVKFHASFVEQD--NFCIITEYCEGRDLDYKIQEYKEAG 127 Query: 279 RKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + + +W Q+L G+ Y+H I+HRDLK NIF+ N +KIGD G++ Sbjct: 128 KIFPDNQIIEWFIQLLLGVDYMHERR--ILHRDLKSKNIFLKNNL--LKIGDFGVS 179
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 52.4 bits (124), Expect = 5e-07 Identities = 43/137 (31%), Positives = 67/137 (48%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY A D G EVA Q+ L Q E + EI +++ K+ NI+ + S++ Sbjct: 283 TVYTAMDVATGQEVAIKQMNL----QQQPKKELIINEILVMRENKNPNIVNYLDSYL--V 336 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E G+L + ++ + CR+ L L +LHS+ +IHRD+K D Sbjct: 337 GDELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALEFLHSNQ--VIHRDIKSD 393 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + G G VK+ D G Sbjct: 394 NILL-GMDGSVKLTDFG 409
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 52.4 bits (124), Expect = 5e-07 Identities = 43/137 (31%), Positives = 67/137 (48%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY A D G EVA Q+ L Q E + EI +++ K+ NI+ + S++ Sbjct: 283 TVYTAMDVATGQEVAIKQMNL----QQQPKKELIINEILVMRENKNPNIVNYLDSYL--V 336 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E G+L + ++ + CR+ L L +LHS+ +IHRD+K D Sbjct: 337 GDELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALEFLHSNQ--VIHRDIKSD 393 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + G G VK+ D G Sbjct: 394 NILL-GMDGSVKLTDFG 409
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 52.4 bits (124), Expect = 5e-07 Identities = 43/142 (30%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ G VA +++L + P R EI LLK L+H NI+ + S Sbjct: 18 VYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSLQDVLMQDS 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+++ HS ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ ++G +K+ D GLA Sbjct: 130 KPQNLLID-DKGTIKLADFGLA 150
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 52.4 bits (124), Expect = 5e-07 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + P R EI LLK L+H NI+ + S Sbjct: 18 VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSLQDVLMQDS 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+++ HS ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ ++G +K+ D GLA Sbjct: 130 KPQNLLID-DKGTIKLADFGLA 150
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 52.4 bits (124), Expect = 5e-07 Identities = 42/139 (30%), Positives = 71/139 (51%), Gaps = 1/139 (0%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 VY+A +++ VA +V + ++L + EI LLK L H NI+K Y ++ S Sbjct: 39 VYKAINKHTDQVVAIKEV----VYENDEELNDIMAEISLLKNLNHNNIVK-YHGFIRKS- 92 Query: 213 RHINFITEMFTSGTLRQ-YRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E +G+LR+ + ++ K + Q L GL YLH +IHRD+K Sbjct: 93 YELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEG--VIHRDIKAA 150 Query: 390 NIFVNGNQGEVKIGDLGLA 446 NI ++ + VK+ D G++ Sbjct: 151 NILLSAD-NTVKLADFGVS 168
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 52.4 bits (124), Expect = 5e-07 Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 3/94 (3%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKV---NIWAVKD 308 E+ +L L+H N+++F + H +TE G+LRQ+ H + N Sbjct: 1335 EVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLK 1394 Query: 309 WCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGN 410 I G+ YLH PPI+HRDL NI ++ N Sbjct: 1395 LALDIAKGMNYLHGWTPPILHRDLSSRNILLDHN 1428
>MK06_HUMAN (Q16659) Mitogen-activated protein kinase 6 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) Length = 721 Score = 52.4 bits (124), Expect = 5e-07 Identities = 42/155 (27%), Positives = 74/155 (47%), Gaps = 17/155 (10%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V+ A D VA ++ L D P ++ EI +++ L H NI+K + + Sbjct: 34 VFSAVDNDCDKRVAIKKIVLTD----PQSVKHALREIKIIRRLDHDNIVKVFEILGPSGS 89 Query: 213 R---HINFITEMFTSGTLRQYRQ--------------KHRKVNIWAVKDWCRQILSGLLY 341 + + +TE+ + +++Y + +H ++ ++ Q+L GL Y Sbjct: 90 QLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMY-------QLLRGLKY 142 Query: 342 LHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +HS N ++HRDLK N+F+N +KIGD GLA Sbjct: 143 IHSAN--VLHRDLKPANLFINTEDLVLKIGDFGLA 175
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 52.4 bits (124), Expect = 5e-07 Identities = 45/140 (32%), Positives = 68/140 (48%), Gaps = 1/140 (0%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY+ + G VA ++L + P R E LLK LKH NI+ + + Sbjct: 148 TVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIR---EASLLKGLKHANIVLLHDI---IH 201 Query: 210 ARHINFITEMFTSGTLRQYRQKHRK-VNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKC 386 + + + L QY KH ++ VK + Q+L GL Y+H I+HRDLK Sbjct: 202 TKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRY--ILHRDLKP 259 Query: 387 DNIFVNGNQGEVKIGDLGLA 446 N+ ++ + GE+K+ D GLA Sbjct: 260 QNLLIS-DTGELKLADFGLA 278
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 52.4 bits (124), Expect = 5e-07 Identities = 37/106 (34%), Positives = 52/106 (49%), Gaps = 3/106 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA---VKD 308 E LL LKH NI+ + SW + +I F G + K +K + V + Sbjct: 53 EAQLLSQLKHPNIVTYKESWEGGDG--LLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVE 110 Query: 309 WCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W QI L YLH + I+HRDLK N+F+ +K+GDLG+A Sbjct: 111 WFVQIAMALQYLHEKH--ILHRDLKTQNVFLT-RTNIIKVGDLGIA 153
>CDC2A_ARATH (P24100) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 52.4 bits (124), Expect = 5e-07 Identities = 41/141 (29%), Positives = 70/141 (49%), Gaps = 3/141 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+A D+ +A +++L + P R EI LLK ++H NI+K V S Sbjct: 18 VYKARDKVTNETIALKKIRLEQEDEGVPSTAIR---EISLLKEMQHSNIVKLQD--VVHS 72 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVN--IWAVKDWCRQILSGLLYLHSHNPPIIHRDLK 383 + + + E + L+++ + + +K + QIL G+ Y HSH ++HRDLK Sbjct: 73 EKRLYLVFE-YLDLDLKKHMDSTPDFSKDLHMIKTYLYQILRGIAYCHSHR--VLHRDLK 129 Query: 384 CDNIFVNGNQGEVKIGDLGLA 446 N+ ++ +K+ D GLA Sbjct: 130 PQNLLIDRRTNSLKLADFGLA 150
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 52.4 bits (124), Expect = 5e-07 Identities = 37/106 (34%), Positives = 52/106 (49%), Gaps = 3/106 (2%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWA---VKD 308 E LL LKH NI+ + SW + +I F G + K +K + V + Sbjct: 53 EAQLLSQLKHPNIVTYKESWEGGDG--LLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVE 110 Query: 309 WCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 W QI L YLH + I+HRDLK N+F+ +K+GDLG+A Sbjct: 111 WFVQIAMALQYLHEKH--ILHRDLKTQNVFLT-RTNIIKVGDLGIA 153
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 52.4 bits (124), Expect = 5e-07 Identities = 34/101 (33%), Positives = 51/101 (50%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI + L+H NI++ Y + D AR + I E G L + QK K++ Sbjct: 91 EIEIQAHLQHPNILRLYNYFHD--ARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIE 148 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 ++ L Y H +IHRD+K +N+ + G +GEVKI D G Sbjct: 149 ELADALTYCHDKK--VIHRDIKPENLLL-GFRGEVKIADFG 186
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 52.4 bits (124), Expect = 5e-07 Identities = 31/74 (41%), Positives = 46/74 (62%) Frame = +3 Query: 225 FITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVN 404 ++ E+ +G L QY +K+R ++ V+ + +ILS + Y+HS IIHRDLK +NI + Sbjct: 130 YVLELAPNGELLQYIKKYRFLDENCVRFYAAEILSSIEYMHSCG--IIHRDLKPENILFD 187 Query: 405 GNQGEVKIGDLGLA 446 GN VKI D G A Sbjct: 188 GNM-HVKITDFGTA 200
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 52.4 bits (124), Expect = 5e-07 Identities = 36/111 (32%), Positives = 56/111 (50%) Frame = +3 Query: 114 DDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNI 293 D + ++ EI LK +H +I+K Y V + + E + G L Y KH +V Sbjct: 56 DVVGKIKREIQNLKLFRHPHIIKLYQ--VISTPTDFFMVMEYVSGGELFDYICKHGRVEE 113 Query: 294 WAVKDWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 + +QILS + Y H H ++HRDLK +N+ ++ Q KI D GL+ Sbjct: 114 MEARRLFQQILSAVDYCHRH--MVVHRDLKPENVLLDA-QMNAKIADFGLS 161
>MK06_RAT (P27704) Mitogen-activated protein kinase 6 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 3) (ERK-3) (p55-MAPK) Length = 720 Score = 52.4 bits (124), Expect = 5e-07 Identities = 42/155 (27%), Positives = 74/155 (47%), Gaps = 17/155 (10%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V+ A D VA ++ L D P ++ EI +++ L H NI+K + + Sbjct: 34 VFSAVDNDCDKRVAIKKIVLTD----PQSVKHALREIKIIRRLDHDNIVKVFEILGPSGS 89 Query: 213 R---HINFITEMFTSGTLRQYRQ--------------KHRKVNIWAVKDWCRQILSGLLY 341 + + +TE+ + +++Y + +H ++ ++ Q+L GL Y Sbjct: 90 QLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMY-------QLLRGLKY 142 Query: 342 LHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +HS N ++HRDLK N+F+N +KIGD GLA Sbjct: 143 IHSAN--VLHRDLKPANLFINTEDLVLKIGDFGLA 175
>MK06_MOUSE (Q61532) Mitogen-activated protein kinase 6 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 3) (ERK-3) Length = 720 Score = 52.4 bits (124), Expect = 5e-07 Identities = 42/155 (27%), Positives = 74/155 (47%), Gaps = 17/155 (10%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVSA 212 V+ A D VA ++ L D P ++ EI +++ L H NI+K + + Sbjct: 34 VFSAVDNDCDKRVAIKKIVLTD----PQSVKHALREIKIIRRLDHDNIVKVFEILGPSGS 89 Query: 213 R---HINFITEMFTSGTLRQYRQ--------------KHRKVNIWAVKDWCRQILSGLLY 341 + + +TE+ + +++Y + +H ++ ++ Q+L GL Y Sbjct: 90 QLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMY-------QLLRGLKY 142 Query: 342 LHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA 446 +HS N ++HRDLK N+F+N +KIGD GLA Sbjct: 143 IHSAN--VLHRDLKPANLFINTEDLVLKIGDFGLA 175
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 52.4 bits (124), Expect = 5e-07 Identities = 43/137 (31%), Positives = 67/137 (48%) Frame = +3 Query: 30 TVYRAFDEYQGMEVAWNQVKLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 TVY A D G EVA Q+ L Q E + EI +++ K+ NI+ + S++ Sbjct: 282 TVYTAMDVATGQEVAIKQMNL----QQQPKKELIINEILVMRENKNPNIVNYLDSYL--V 335 Query: 210 ARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDLKCD 389 + + E G+L + ++ + CR+ L L +LHS+ +IHRD+K D Sbjct: 336 GDELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALEFLHSNQ--VIHRDIKSD 392 Query: 390 NIFVNGNQGEVKIGDLG 440 NI + G G VK+ D G Sbjct: 393 NILL-GMDGSVKLTDFG 408
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 52.0 bits (123), Expect = 7e-07 Identities = 41/142 (28%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + P R E+ LL+ LKH N+++ + S Sbjct: 18 VYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVR---EVSLLQELKHPNVVRLLDVLMQES 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+ + H ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ N+G +K+ D GLA Sbjct: 130 KPQNLLID-NKGVIKLADFGLA 150
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 52.0 bits (123), Expect = 7e-07 Identities = 41/142 (28%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + P R E+ LL+ LKH N+++ + S Sbjct: 18 VYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVR---EVSLLQELKHPNVVRLLDVLMQES 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+ + H ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ N+G +K+ D GLA Sbjct: 130 KPQNLLID-NKGVIKLADFGLA 150
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 52.0 bits (123), Expect = 7e-07 Identities = 41/142 (28%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + P R E+ LL+ LKH N+++ + S Sbjct: 18 VYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVR---EVSLLQELKHPNVVRLLDVLMQES 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+ + H ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ N+G +K+ D GLA Sbjct: 130 KPQNLLID-NKGVIKLADFGLA 150
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 52.0 bits (123), Expect = 7e-07 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +3 Query: 33 VYRAFDEYQGMEVAWNQVKLYDFLQ-CPDDLERLYCEIHLLKTLKHKNIMKFYTSWVDVS 209 VY+ + G VA +++L + P R EI LLK L+H NI+ + S Sbjct: 18 VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSLQDVLMQDS 74 Query: 210 ARHINFITEMFTSGTLRQYRQK---HRKVNIWAVKDWCRQILSGLLYLHSHNPPIIHRDL 380 ++ F F S L++Y + ++ VK + QIL G+++ HS ++HRDL Sbjct: 75 RLYLIF---EFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRR--VLHRDL 129 Query: 381 KCDNIFVNGNQGEVKIGDLGLA 446 K N+ ++ ++G +K+ D GLA Sbjct: 130 KPQNLLID-DKGTIKLADFGLA 150
>JAK_DROME (Q24592) Tyrosine-protein kinase hopscotch (EC 2.7.10.2)| Length = 1177 Score = 52.0 bits (123), Expect = 7e-07 Identities = 51/149 (34%), Positives = 70/149 (46%), Gaps = 5/149 (3%) Frame = +3 Query: 15 RARPXTVYRAFDEYQGMEVAWNQV--KLYDFLQCPDDLERLYCEIHLLKTLKHKNIMKFY 188 R TVY+ E+ + QV K+ + +Q D R EI +++TL H NI+KF Sbjct: 900 RGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHR---EIGIMRTLSHPNIVKF- 955 Query: 189 TSWVDVSARHINFITEMFTSGTLRQY-RQKHRKVNIWAVKDWCRQILSGLLYLHSHNPPI 365 W + S H I E SG+ Y R +N + + I +G+ YL + Sbjct: 956 KYWAEKS--HC-IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMG--L 1010 Query: 366 IHRDLKCDNIFV--NGNQGEVKIGDLGLA 446 IHRDL NI V NG+ VKI D GLA Sbjct: 1011 IHRDLAARNILVDHNGDGDCVKISDFGLA 1039
>KIN4_YEAST (Q01919) Serine/threonine-protein kinase KIN4 (EC 2.7.11.1)| Length = 800 Score = 52.0 bits (123), Expect = 7e-07 Identities = 32/105 (30%), Positives = 59/105 (56%) Frame = +3 Query: 126 RLYCEIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVK 305 ++Y EI+ LK L H NI+ Y V ++++I + E + G +Y Q+ R++ + Sbjct: 96 KIYREINALKHLTHPNII--YLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSAC 153 Query: 306 DWCRQILSGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG 440 Q++SG+ Y+H ++HRDLK +N+ ++ ++ V I D G Sbjct: 154 RLFAQLISGVNYMHYKG--LVHRDLKLENLLLDKHENLV-ITDFG 195
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 52.0 bits (123), Expect = 7e-07 Identities = 38/111 (34%), Positives = 51/111 (45%), Gaps = 8/111 (7%) Frame = +3 Query: 138 EIHLLKTLKHKNIMKFYTSWVDVSARHINFITEMFTSGTLRQYRQKHRKVNIWAVKDWCR 317 EI +LK LKH+NI+ Y A + + E G L Y R ++ ++ + + Sbjct: 63 EIKILKELKHENIVALYD--FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ 120 Query: 318 QILSGLLYLHSHNPPIIHRDLKCDNIFV--------NGNQGEVKIGDLGLA 446 QI + LHS IIHRDLK NI + N N VKI D G A Sbjct: 121 QIAGAMRLLHSKG--IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFA 169 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 52,531,267 Number of Sequences: 219361 Number of extensions: 1082048 Number of successful extensions: 7035 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5746 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6397 length of database: 80,573,946 effective HSP length: 102 effective length of database: 58,199,124 effective search space used: 2677159704 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
