ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | rbasd22e10 |
|---|---|
| Clone Library Name | barley_pub |
>AKR2_ARATH (Q9SAR5) Ankyrin repeat domain-containing protein 2 (AtAKR2)| Length = 342 Score = 189 bits (480), Expect = 6e-48 Identities = 92/116 (79%), Positives = 104/116 (89%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S+GD EGLK AL G NKDEED EGR ALHFACGYGELKCA++L++AGA+V+A+DKNKNT Sbjct: 227 SLGDVEGLKAALASGGNKDEEDSEGRTALHFACGYGELKCAQVLIDAGASVNAVDKNKNT 286 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL 302 PLHYAAGYGRKECV LLL++GAAV LQNLD KTPI+VAKLNSQ EVVKLLE+D FL Sbjct: 287 PLHYAAGYGRKECVSLLLENGAAVTLQNLDEKTPIDVAKLNSQLEVVKLLEKDAFL 342
>TNKS2_HUMAN (Q9H2K2) Tankyrase 2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2)| (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein) Length = 1166 Score = 76.6 bits (187), Expect = 6e-14 Identities = 48/112 (42%), Positives = 63/112 (56%), Gaps = 2/112 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 GD E +KK L + + D+EGR++ LHFA GY + E LL+ GA V A DK Sbjct: 503 GDVETVKK-LCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 PLH A YG E +LL+KHGA V + +L TP+ A + E+ KLL Q Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613 Score = 73.9 bits (180), Expect = 4e-13 Identities = 43/105 (40%), Positives = 59/105 (56%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ +D G LH AC YG + AE+L++ GA V+ D K TPLH AA G+ Sbjct: 546 LQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKY 605 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL 302 E LLL+HGA +N DG TP+++ K + ++ LL D L Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVK-DGDTDIQDLLRGDAAL 649 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/106 (39%), Positives = 58/106 (54%), Gaps = 2/106 (1%) Frame = -3 Query: 580 EGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 +GR++ LH A GY +K ++LL+ GA V A DK PLH A YG E +LL+KHG Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 A V +L TP+ A ++ EV LL S +DP L++ Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLL------SYGADPTLLN 307 Score = 67.8 bits (164), Expect = 3e-11 Identities = 42/99 (42%), Positives = 57/99 (57%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ + +D G LH A YG + A +L++ A V+A DK TPLH AA GR Sbjct: 699 LQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRT 758 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LLL HGA L+N +G+TP++ L S D+V LL Sbjct: 759 QLCALLLAHGADPTLKNQEGQTPLD---LVSADDVSALL 794 Score = 63.2 bits (152), Expect = 7e-10 Identities = 39/119 (32%), Positives = 62/119 (52%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L GAN D G LH AC +G + +LL GA +A D TPL Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPS 287 H AA G+ + +LL+HGA ++N DG+T +++A +++ + ++D L S S Sbjct: 129 HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187 Score = 62.8 bits (151), Expect = 9e-10 Identities = 39/103 (37%), Positives = 53/103 (51%), Gaps = 2/103 (1%) Frame = -3 Query: 622 KALDGGANKDEEDVEGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 K L N + D +GR + LH A GY L+ AE LL+ GA V+A DK PLH AA Sbjct: 662 KKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAAS 721 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 YG + LL+K+ A V + TP+ A + ++ LL Sbjct: 722 YGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764 Score = 62.4 bits (150), Expect = 1e-09 Identities = 40/112 (35%), Positives = 58/112 (51%), Gaps = 2/112 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 GD E +K+ + + D GR++ LHFA G+G E LL+ GA V A D Sbjct: 35 GDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLI 93 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 PLH A +G E V+LLL+HGA ++ TP+ A + + +V +L Q Sbjct: 94 PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145 Score = 60.1 bits (144), Expect = 6e-09 Identities = 35/87 (40%), Positives = 48/87 (55%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ +D LH AC YG + E+L++ GA V+A+D + TPLH AA R Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRV 290 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVA 356 E LLL +GA L N K+ I++A Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLA 317 Score = 49.3 bits (116), Expect = 1e-05 Identities = 37/102 (36%), Positives = 45/102 (44%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K L G KDE L A E K +L A D K+TPLH AAGY Sbjct: 169 KAVLTGEYKKDE-------LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 R + V LLL+HGA V ++ P+ A EV +LL Sbjct: 222 NRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263 Score = 46.2 bits (108), Expect = 8e-05 Identities = 34/113 (30%), Positives = 56/113 (49%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN +E+ E LH A E++++ A V+ALD T LH AA G + Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 LLL +G + +L G T +++ N Q +LL++ + L + +D L++ Sbjct: 450 RLLLSYGCDPNIISLQGFTALQMGNENVQ----QLLQEGISLGNSEADRQLLE 498 Score = 35.0 bits (79), Expect = 0.19 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 3/86 (3%) Frame = -3 Query: 568 ALHFACG--YGELK-CAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 ALH A Y + K E+LL GA ++ K TPLH A+ + V++++KH A V Sbjct: 367 ALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKV 426 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G+T + A + +LL Sbjct: 427 NALDNLGQTSLHRAAYCGHLQTCRLL 452
>TNKS1_HUMAN (O95271) Tankyrase 1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1)| (TRF1-interacting ankyrin-related ADP-ribose polymerase) Length = 1327 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/105 (42%), Positives = 59/105 (56%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ +D G LH AC YG + AE+L+ GA+V+ D K TPLH AA G+ Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL 302 E LLLKHGA +N DG TP+++ K D + LL+ D L Sbjct: 764 EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTD-IQDLLKGDAAL 807 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/110 (41%), Positives = 61/110 (55%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 GD E +K+ L N + D+EGR + LHFA GY + E LL GA V A DK Sbjct: 661 GDLETVKQ-LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLV 719 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH A YG E +LL++HGA+V + +L TP+ A + E+ KLL Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLL 769 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/106 (39%), Positives = 58/106 (54%), Gaps = 2/106 (1%) Frame = -3 Query: 580 EGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 +GR++ LH A GY ++ ++LL+ GA V A DK PLH A YG E +LLLKHG Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 A V +L TP+ A ++ EV LL S +DP L++ Sbjct: 426 ACVNAMDLWQFTPLHEAASKNRVEVCSLLL------SHGADPTLVN 465 Score = 68.2 bits (165), Expect = 2e-11 Identities = 38/87 (43%), Positives = 50/87 (57%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ +D G LH AC YG + E+LL+ GA V+A+D + TPLH AA R Sbjct: 389 LQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRV 448 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVA 356 E LLL HGA L N GK+ +++A Sbjct: 449 EVCSLLLSHGADPTLVNCHGKSAVDMA 475 Score = 65.9 bits (159), Expect = 1e-10 Identities = 38/99 (38%), Positives = 58/99 (58%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ + +D G LH A YG + A +L++ V+A DK TPLH AA GR Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LLL HGA ++N +G+TP+++A + D++ LL Sbjct: 917 QLCALLLAHGADPTMKNQEGQTPLDLA---TADDIRALL 952 Score = 62.4 bits (150), Expect = 1e-09 Identities = 41/112 (36%), Positives = 59/112 (52%), Gaps = 2/112 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 GD +K+ +D AN + +D+ GR++ LHFA G+G E LL+ GA V A D Sbjct: 193 GDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 PLH A +G E V LLL GA ++ TP+ A + + +V +L Q Sbjct: 252 PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303 Score = 60.5 bits (145), Expect = 4e-09 Identities = 36/91 (39%), Positives = 48/91 (52%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRA--LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 D +GR + LH A GY L+ AE LLE GA V+A DK PLH AA YG + LL+K Sbjct: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V + TP+ A + ++ LL Sbjct: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/96 (36%), Positives = 52/96 (54%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L GAN D G LH AC +G + +LL GA +A D TPL Sbjct: 227 GRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H AA G+ + +LL+HGA ++N DGK+ +++A Sbjct: 287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322 Score = 51.6 bits (122), Expect = 2e-06 Identities = 38/102 (37%), Positives = 45/102 (44%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K L G KDE L A E K +L A D K+TPLH AAGY Sbjct: 327 KAVLTGEYKKDE-------LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY 379 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 R V LLL+HGA V ++ G P+ A EV +LL Sbjct: 380 NRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421 Score = 41.6 bits (96), Expect = 0.002 Identities = 29/85 (34%), Positives = 44/85 (51%) Frame = -3 Query: 526 EILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLN 347 E+LL GA V+ +K+ TPLH AA + +++L KHGA + + G+T + A L Sbjct: 542 ELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALA 601 Query: 346 SQDEVVKLLEQDVFL*SKPSDPVLI 272 + +LL S SDP +I Sbjct: 602 GHLQTCRLLL------SYGSDPSII 620 Score = 41.2 bits (95), Expect = 0.003 Identities = 27/83 (32%), Positives = 42/83 (50%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN +E++ + LH A E+L + GA ++ALD T LH AA G + Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC 607 Query: 427 DLLLKHGAAVMLQNLDGKTPIEV 359 LLL +G+ + +L G T ++ Sbjct: 608 RLLLSYGSDPSIISLQGFTAAQM 630 Score = 33.5 bits (75), Expect = 0.56 Identities = 20/60 (33%), Positives = 34/60 (56%), Gaps = 3/60 (5%) Frame = -3 Query: 484 KNKNTPLHYAAGY---GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++ T LH A RK+ +LLL+ GA V +N D TP+ VA + ++V+++L + Sbjct: 520 QSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK 579
>ANR11_HUMAN (Q6UB99) Ankyrin repeat domain-containing protein 11 (Ankyrin| repeat-containing cofactor 1) Length = 2664 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/138 (36%), Positives = 71/138 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GDA +K+ + GA+ + +D G ALH AC G A+ LL AGA V+ + +TPL Sbjct: 180 GDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPL 239 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 H AA G + V LLL++G N G+TP++VA NS V LL + + S+ S Sbjct: 240 HDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA--NSPTMVNLLLGKGTYTSSEESS 297 Query: 283 PVLIDPKTLPCFWSLSGV 230 + + P F S V Sbjct: 298 TESSEEEDAPSFAPSSSV 315 Score = 44.7 bits (104), Expect = 2e-04 Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 5/107 (4%) Frame = -3 Query: 625 KKALDGGANKDEEDVE-----GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +K A+K ++ V G LH A G+ + + L+ GA V+ D T LH Sbjct: 148 QKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALH 207 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G + LL GA V + LD TP+ A N +VVKLL Sbjct: 208 EACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLL 254
>ASB8_MOUSE (Q91ZT9) Ankyrin repeat and SOCS box protein 8 (ASB-8)| Length = 288 Score = 73.2 bits (178), Expect = 6e-13 Identities = 44/109 (40%), Positives = 62/109 (56%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 V DA+ ++ L+ GA + D R ALH+A E C E+LLE GA +ALD N++TP Sbjct: 63 VSDADCVELLLEKGAEVNALDGYNRTALHYAAERDEA-CVEVLLEYGANPNALDGNRDTP 121 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+AA ECV LL+ GA+V + + TP+ A + E V +L Sbjct: 122 LHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170 Score = 68.6 bits (166), Expect = 2e-11 Identities = 38/84 (45%), Positives = 51/84 (60%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + D LH+A +C LLE+GA+V+ALD N +TPL +AA G Sbjct: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPI 365 E V +LL +GA V + NL G+TPI Sbjct: 165 ESVSILLDYGAEVRVINLKGQTPI 188 Score = 56.6 bits (135), Expect = 6e-08 Identities = 33/84 (39%), Positives = 47/84 (55%) Frame = -3 Query: 571 RALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVML 392 + LH AC + C E+LLE GA V+ALD T LHYAA + CV++LL++GA Sbjct: 55 KPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAERD-EACVEVLLEYGANPNA 113 Query: 391 QNLDGKTPIEVAKLNSQDEVVKLL 320 + + TP+ A + E V+ L Sbjct: 114 LDGNRDTPLHWAAFKNNAECVRAL 137 Score = 32.0 bits (71), Expect = 1.6 Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 8/104 (7%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE ++ L+ GA+ + D L +A G L+ ILL+ GA V ++ TP+ Sbjct: 130 NAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPIS 189 Query: 460 -----YAAGYGRKE---CVDLLLKHGAAVMLQNLDGKTPIEVAK 353 G G ++ C +LL + L+ +G P EV K Sbjct: 190 RLVALLVRGLGTEKEDSCFELLHRAVGQFELRK-NGIMPREVTK 232
>ASB8_HUMAN (Q9H765) Ankyrin repeat and SOCS box protein 8 (ASB-8)| Length = 288 Score = 73.2 bits (178), Expect = 6e-13 Identities = 44/109 (40%), Positives = 62/109 (56%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 V DA+ ++ L+ GA + D R ALH+A E C E+LLE GA +ALD N++TP Sbjct: 63 VSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTP 121 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+AA ECV LL+ GA+V + + TP+ A + E V +L Sbjct: 122 LHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170 Score = 67.8 bits (164), Expect = 3e-11 Identities = 38/84 (45%), Positives = 51/84 (60%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + D LH+A +C LLE+GA+V+ALD N +TPL +AA G Sbjct: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPI 365 E V +LL +GA V + NL G+TPI Sbjct: 165 ESVSILLDYGAEVRVINLIGQTPI 188 Score = 56.6 bits (135), Expect = 6e-08 Identities = 33/84 (39%), Positives = 47/84 (55%) Frame = -3 Query: 571 RALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVML 392 + LH AC + C E+LLE GA V+ALD T LHYAA + CV++LL++GA Sbjct: 55 KPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLEYGANPNA 113 Query: 391 QNLDGKTPIEVAKLNSQDEVVKLL 320 + + TP+ A + E V+ L Sbjct: 114 LDGNRDTPLHWAAFKNNAECVRAL 137 Score = 31.6 bits (70), Expect = 2.1 Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 8/104 (7%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE ++ L+ GA+ + D L +A G L+ ILL+ GA V ++ TP+ Sbjct: 130 NAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189 Query: 460 -----YAAGYGRKE---CVDLLLKHGAAVMLQNLDGKTPIEVAK 353 G G ++ C +LL + L+ +G P EVA+ Sbjct: 190 RLVALLVRGLGTEKEDSCFELLHRAVGHFELRK-NGTMPREVAR 232
>ANR12_HUMAN (Q6UB98) Ankyrin repeat domain-containing protein 12 (Ankyrin| repeat-containing cofactor 2) (GAC-1 protein) Length = 2062 Score = 72.8 bits (177), Expect = 8e-13 Identities = 41/112 (36%), Positives = 65/112 (58%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + +K+ + GAN + +D G LH AC G A+IL+ AGA V+ + +TPL Sbjct: 196 GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 255 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDV 308 H +A G ++ V LLL+HG N G+ P++VA+ +E+ LL+++V Sbjct: 256 HDSASSGHRDIVKLLLRHGGNAFQANKHGERPVDVAE---TEELELLLKREV 304 Score = 50.4 bits (119), Expect = 4e-06 Identities = 30/92 (32%), Positives = 46/92 (50%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 ++ + G LH A G++K + L+ GA V+ D TPLH A G + +L+ Sbjct: 179 NKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI 238 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 GA V Q LD TP+ + + ++VKLL Sbjct: 239 AAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 270
>CSKI2_HUMAN (Q8WXE0) Caskin-2| Length = 1202 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/96 (44%), Positives = 55/96 (57%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + +D +G ALH A G L+ +LLEA A VD D N PLHYAA GR E V L Sbjct: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LL+ AAV +LDG+ P+ +A EV ++L Q Sbjct: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ 136 Score = 65.9 bits (159), Expect = 1e-10 Identities = 40/108 (37%), Positives = 58/108 (53%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + L+ A D +D G R LH+A G L+ +LL A AAV+A + PL Sbjct: 60 GSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA YG E ++LL+H + L N KTP+++A + +V +LL Sbjct: 120 HLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167 Score = 49.3 bits (116), Expect = 1e-05 Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 8/116 (6%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L A + ++G+ LH A YG + +E+LL+ + ++K K TPL Sbjct: 93 GRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPL 152 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGK--------TPIEVAKLNSQDEVVKLL 320 A +GR + LLL V L + K TP+ +A N EV++ L Sbjct: 153 DLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 208 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/102 (31%), Positives = 48/102 (47%) Frame = -3 Query: 619 ALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 AL G KD D LH A G + LL AG ++ K T LH AA YG+ Sbjct: 175 ALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKT-GTALHEAALYGK 233 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 E V LLL+ G V ++N +T +++ + + + ++Q Sbjct: 234 TEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
>CSKI2_MOUSE (Q8VHK1) Caskin-2| Length = 1201 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/96 (44%), Positives = 55/96 (57%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + +D +G ALH A G L+ +LLEA A VD D N PLHYAA GR E V L Sbjct: 41 NINYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LL+ AAV +LDG+ P+ +A EV ++L Q Sbjct: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ 136 Score = 65.1 bits (157), Expect = 2e-10 Identities = 40/108 (37%), Positives = 58/108 (53%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + L+ A D +D G R LH+A G L+ +LL A AAV+A + PL Sbjct: 60 GSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA YG E ++LL+H + L N KTP+++A + +V +LL Sbjct: 120 HLAAQYGHYEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGRLKVAQLL 167 Score = 54.3 bits (129), Expect = 3e-07 Identities = 36/90 (40%), Positives = 46/90 (51%), Gaps = 8/90 (8%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEA--------GAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 L AC +G LK A++LL + G A D D N TPLH AA G +E + LLK Sbjct: 152 LDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLKA 211 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G + Q G T + A L + EVV+LL Sbjct: 212 GIEINRQTKTG-TALHEAALYGKTEVVRLL 240 Score = 48.9 bits (115), Expect = 1e-05 Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 8/116 (6%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L A + ++G+ LH A YG + +E+LL+ + ++K K TPL Sbjct: 93 GRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKLKKTPL 152 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGK--------TPIEVAKLNSQDEVVKLL 320 A +GR + LLL V L + K TP+ +A N EV++ L Sbjct: 153 DLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 208 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/102 (31%), Positives = 49/102 (48%) Frame = -3 Query: 619 ALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 AL G KD D LH A G + LL+AG ++ K T LH AA YG+ Sbjct: 175 ALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLKAGIEINRQTKT-GTALHEAALYGK 233 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 E V LLL+ G V ++N +T +++ + + + ++Q Sbjct: 234 TEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 70.9 bits (172), Expect = 3e-12 Identities = 41/109 (37%), Positives = 55/109 (50%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + L+ A+ +E D EGR +H AC +G+ ILL G V K+ PL Sbjct: 563 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 622 Query: 463 HYAAGYGRKECVDLLLKH-GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 HYAA G V LL K G +V Q LDG+TP+ +A V ++L Sbjct: 623 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 671 Score = 57.8 bits (138), Expect = 3e-08 Identities = 32/90 (35%), Positives = 47/90 (52%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 +D + ALHFA G+ +LLE A+V+ +D TP+H A +G++ V +LL+ Sbjct: 548 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 607 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G V LQ D P+ A +VKLL Sbjct: 608 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 637 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/108 (32%), Positives = 56/108 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E K L AN + + G LH A E+LL +V+A D+++ T L Sbjct: 497 GQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 556 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G + LLL+ A+V + +G+TP+ VA + Q+ +V++L Sbjct: 557 HFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 604 Score = 53.1 bits (126), Expect = 7e-07 Identities = 32/99 (32%), Positives = 46/99 (46%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + + ++GR LH A G + A IL++ + V+ TPLH AA G Sbjct: 642 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 701 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 LLL GA DG T + +A N VKLL ++ Sbjct: 702 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 740 Score = 39.3 bits (90), Expect = 0.010 Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 5/113 (4%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVE-----GRRALHFACGYGELKCAEILLEAGAAVDALDKN 479 GD L K L +DV+ G LH A G+ +CA+ LL A + ++ Sbjct: 465 GDTSKLMKILQ------PQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRR 518 Query: 478 KNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +TPLH A + V+LLL +V ++ D T + A N + +LL Sbjct: 519 GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 571
>ANK3_HUMAN (Q12955) Ankyrin-3 (ANK-3) (Ankyrin-G)| Length = 4377 Score = 70.9 bits (172), Expect = 3e-12 Identities = 39/105 (37%), Positives = 59/105 (56%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD AN + + + G LH AC +K E+LL+ GA++ A+ ++ TP+H AA Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 G V L+ HGA+ N+ G+T + +A + Q EVV+ L QD Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488 Score = 67.0 bits (162), Expect = 5e-11 Identities = 38/107 (35%), Positives = 51/107 (47%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 D + L N D E G LH A YG + A +LL AAVD +N TPLH Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A+ G V LLL GA + + DG TP+ + ++VV++L Sbjct: 274 VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320 Score = 65.5 bits (158), Expect = 1e-10 Identities = 41/108 (37%), Positives = 56/108 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + + L AN D +G ALH A G+ + ++L+ GA V+A +N TPL Sbjct: 85 GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + AA E V LL +GA+ L DG TP+ VA D+VV LL Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192 Score = 63.2 bits (152), Expect = 7e-10 Identities = 40/101 (39%), Positives = 54/101 (53%), Gaps = 1/101 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 LD GA+ +G LH A YG+L+ A +LL+ A+ DA K+ TPLH AA Y + Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEV-AKLNSQDEVVKLLE 317 + LLL GA+ +G TP+ + AK N D LLE Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652 Score = 60.1 bits (144), Expect = 6e-09 Identities = 32/109 (29%), Positives = 55/109 (50%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + + + GA+ + +V G ALH A G+ + L++ GA V+A K+ TP Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH +A G+ + V LL+ GA+ G TP+ ++ ++V L Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551 Score = 59.7 bits (143), Expect = 7e-09 Identities = 41/106 (38%), Positives = 58/106 (54%), Gaps = 3/106 (2%) Frame = -3 Query: 628 LKKALD---GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHY 458 L+KALD G + + + G ALH A G ++ LL+ A VDA K NT LH Sbjct: 54 LEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHI 113 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A+ G+ E V +L+ +GA V Q+ +G TP+ +A + EVVK L Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/111 (31%), Positives = 52/111 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + + L AN + + G LH A + AE+L+ GA VDA K TPL Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 H YG + V+ LL+H A V + +G TP+ A ++ +L Q+ Sbjct: 735 HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQN 785 Score = 58.5 bits (140), Expect = 2e-08 Identities = 33/97 (34%), Positives = 50/97 (51%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ D + G LH C YG +K LL+ A V+A KN TPLH AA G + Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 ++LL++ A+ ++G T + +A+ VV L+ Sbjct: 780 NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816 Score = 57.8 bits (138), Expect = 3e-08 Identities = 36/109 (33%), Positives = 53/109 (48%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G A+ +++ L GA+ + G LH + G A LL+ GA++ K TP Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG+ E +LLL+ A+ G TP+ VA +V LL Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/110 (30%), Positives = 56/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G AE ++ + GA + + + + LH + G+ + LL+ GA+ +A + TPL Sbjct: 477 GQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H +A G ++ LL HGA++ + G TP+ VA + EV LL Q Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ 586 Score = 55.1 bits (131), Expect = 2e-07 Identities = 33/83 (39%), Positives = 43/83 (51%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 ALH A G K A++LL+ A +A N TPLH A R + ++LLLKHGA++ Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 G TPI VA +V L Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQL 452 Score = 52.0 bits (123), Expect = 2e-06 Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 3/94 (3%) Frame = -3 Query: 592 EEDVEGR---RALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 E D +G+ ALH A + K A +LL+ D K+ TPLH AA YG L Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATL 253 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL AAV + TP+ VA +VKLL Sbjct: 254 LLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287 Score = 51.6 bits (122), Expect = 2e-06 Identities = 36/108 (33%), Positives = 50/108 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A +K LD GA D + +G LH G + E+LL+ A + + KN +PL Sbjct: 279 GNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPL 338 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A CV LLL+H V D T + VA +V K+L Sbjct: 339 HMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386 Score = 50.8 bits (120), Expect = 3e-06 Identities = 33/99 (33%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 LD GA+ G LH A ++ A LLE GA +A+ + +H AA G Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V LLL A V L N G TP+ +A + V ++L Sbjct: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716 Score = 50.8 bits (120), Expect = 3e-06 Identities = 27/84 (32%), Positives = 45/84 (53%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A G ++LL+ GA +DA ++ TPLH A G ++ V++LL A ++ + Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331 Query: 385 LDGKTPIEVAKLNSQDEVVKLLEQ 314 +G +P+ +A V+LL Q Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQ 355 Score = 49.7 bits (117), Expect = 8e-06 Identities = 34/108 (31%), Positives = 46/108 (42%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L A+ D G LH A Y K A +LL+ GA+ A KN TPL Sbjct: 576 GKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPL 635 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA + + LL++GA G + +A ++V LL Sbjct: 636 HIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683 Score = 46.2 bits (108), Expect = 8e-05 Identities = 31/101 (30%), Positives = 48/101 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ + +G ++H A G + +LL A V+ +K+ TPLH AA R Sbjct: 651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 710 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++L+ GA V Q G TP+ V ++V L Q Sbjct: 711 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751 Score = 38.9 bits (89), Expect = 0.013 Identities = 24/78 (30%), Positives = 38/78 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G AE +K + GAN + + G L+ A L+ + LL+ GA+ ++ TPL Sbjct: 118 GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL 177 Query: 463 HYAAGYGRKECVDLLLKH 410 A G + V LLL++ Sbjct: 178 AVALQQGHDQVVSLLLEN 195
>ASB10_MOUSE (Q91ZT7) Ankyrin repeat and SOCS box protein 10 (ASB-10)| Length = 467 Score = 70.5 bits (171), Expect = 4e-12 Identities = 41/99 (41%), Positives = 57/99 (57%), Gaps = 1/99 (1%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA-LDKNKN 473 S G A ++ L GA+ + D +G+R LH G G L+C E+LL+ GA VD + + Sbjct: 157 SAGHAACVRVLLVAGADPNTLDQDGKRPLHLCRGPGILECVELLLKFGAQVDGRTEDEEE 216 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 TPLH AA G E DLLL+ GA ++N +G TP+ A Sbjct: 217 TPLHIAARLGHVELADLLLRWGACPDVRNSEGWTPLLAA 255 Score = 64.7 bits (156), Expect = 2e-10 Identities = 45/111 (40%), Positives = 56/111 (50%), Gaps = 1/111 (0%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E L+ L A D GR ALH AC G C +LL AGA + LD++ Sbjct: 125 SRGHTEVLELLLRRRAKPDSAP-GGRTALHEACSAGHAACVRVLLVAGADPNTLDQDGKR 183 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLD-GKTPIEVAKLNSQDEVVKLL 320 PLH G G ECV+LLLK GA V + D +TP+ +A E+ LL Sbjct: 184 PLHLCRGPGILECVELLLKFGAQVDGRTEDEEETPLHIAARLGHVELADLL 234 Score = 43.9 bits (102), Expect = 4e-04 Identities = 37/129 (28%), Positives = 49/129 (37%), Gaps = 16/129 (12%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKC----------------AEILL 515 +G E L GA D + EG L AC +++C +LL Sbjct: 225 LGHVELADLLLRWGACPDVRNSEGWTPLLAAC---DIRCQSPKDAEATTNRCFQLCRLLL 281 Query: 514 EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDE 335 GA DA +++K PLH A +G V LLL G + G TP+ A L Sbjct: 282 SVGADADAANQDKQRPLHLACRHGHSAVVQLLLSCGVNANAMDYGGHTPLHCALLGPTTA 341 Query: 334 VVKLLEQDV 308 V E V Sbjct: 342 VAHSPEHTV 350
>CSKI1_HUMAN (Q8WXD9) Caskin-1 (CASK-interacting protein 1)| Length = 1431 Score = 70.1 bits (170), Expect = 5e-12 Identities = 47/130 (36%), Positives = 69/130 (53%), Gaps = 5/130 (3%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + +D +G ALH A G + +LLEA AAVD D PLHYAA GRKE + L Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID-----PKTL 257 +LK G+AV + + +G P+ +A + +V ++L Q S+P ++D P L Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQ------HQSNPCMVDNSGKTPLDL 154 Query: 256 PCFWSLSGVM 227 C + GV+ Sbjct: 155 ACEFGRVGVV 164 Score = 60.5 bits (145), Expect = 4e-09 Identities = 35/108 (32%), Positives = 62/108 (57%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E + L+ A D +D +G R LH+A G + +++L+AG+AV+ + PL Sbjct: 60 GNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA +G + ++LL+H + + + GKTP+++A + VV+LL Sbjct: 120 HLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167 Score = 47.0 bits (110), Expect = 5e-05 Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 8/97 (8%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAV--------DALDKNKNTPLHYAAGYGRKEC 431 D G+ L AC +G + ++LL + DA D N +PLH AA G + Sbjct: 145 DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI 204 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LLL+ G + Q G T + A L + EVV+LL Sbjct: 205 IRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240 Score = 47.0 bits (110), Expect = 5e-05 Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 8/118 (6%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L G+ + EG LH A +G +E+LL+ + +D + TPL Sbjct: 93 GRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPL 152 Query: 463 HYAAGYGRKECVDLLLKHGAAVML--------QNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A +GR V LLL L + +G +P+ +A N ++++LL Q Sbjct: 153 DLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ 210 Score = 42.4 bits (98), Expect = 0.001 Identities = 27/94 (28%), Positives = 45/94 (47%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D G LH A G + +LL+AG ++ K+ T LH AA G+ E V LLL Sbjct: 183 DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKS-GTALHEAALCGKTEVVRLLL 241 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 G ++N +T +++ + + + ++Q Sbjct: 242 DSGINAHVRNTYSQTALDIVHQFTTSQASREIKQ 275
>CSKI1_RAT (Q8VHK2) Caskin-1 (CASK-interacting protein 1)| Length = 1430 Score = 69.7 bits (169), Expect = 7e-12 Identities = 47/130 (36%), Positives = 69/130 (53%), Gaps = 5/130 (3%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + +D +G ALH A G + +LLEA AAVD D PLHYAA GRKE + L Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID-----PKTL 257 +LK G+AV + + +G P+ +A + +V ++L Q S+P ++D P L Sbjct: 101 VLKAGSAVNVPSDEGHIPLHLAAQHGHYDVSEMLLQ------HQSNPCIVDNSGKTPLDL 154 Query: 256 PCFWSLSGVM 227 C + GV+ Sbjct: 155 ACEFGRVGVV 164 Score = 60.8 bits (146), Expect = 3e-09 Identities = 35/108 (32%), Positives = 62/108 (57%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E + L+ A D +D +G R LH+A G + +++L+AG+AV+ + PL Sbjct: 60 GNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNVPSDEGHIPL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA +G + ++LL+H + + + GKTP+++A + VV+LL Sbjct: 120 HLAAQHGHYDVSEMLLQHQSNPCIVDNSGKTPLDLACEFGRVGVVQLL 167 Score = 47.4 bits (111), Expect = 4e-05 Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 8/118 (6%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L G+ + EG LH A +G +E+LL+ + +D + TPL Sbjct: 93 GRKEPMKLVLKAGSAVNVPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCIVDNSGKTPL 152 Query: 463 HYAAGYGRKECVDLLLKHGAAVML--------QNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A +GR V LLL L + +G +P+ +A N ++++LL Q Sbjct: 153 DLACEFGRVGVVQLLLSSNMCAALLEPRPGDTTDPNGTSPLHLAAKNGHIDIIRLLLQ 210 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 8/97 (8%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAV--------DALDKNKNTPLHYAAGYGRKEC 431 D G+ L AC +G + ++LL + D D N +PLH AA G + Sbjct: 145 DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDTTDPNGTSPLHLAAKNGHIDI 204 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LLL+ G + Q G T + A L + EVV+LL Sbjct: 205 IRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240 Score = 44.3 bits (103), Expect = 3e-04 Identities = 28/94 (29%), Positives = 45/94 (47%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D G LH A G + +LL+AG ++ K+ T LH AA G+ E V LLL Sbjct: 183 DTTDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKS-GTALHEAALCGKTEVVRLLL 241 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 G ++N +T +++ + + K ++Q Sbjct: 242 DSGINAQVRNTYSQTALDIVHQFTTSQASKEIKQ 275
>ASB10_HUMAN (Q8WXI3) Ankyrin repeat and SOCS box protein 10 (ASB-10)| Length = 429 Score = 69.7 bits (169), Expect = 7e-12 Identities = 39/88 (44%), Positives = 52/88 (59%), Gaps = 1/88 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDAL-DKNKNTPLHYAAGYGR 440 L GA+ + D +G+R LH G G L+CAE+LL GA VD ++ + TPLH AA G Sbjct: 168 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 227 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVA 356 E DLLL+ GA +N +G TP+ A Sbjct: 228 VELADLLLRRGACPDARNAEGWTPLLAA 255 Score = 60.1 bits (144), Expect = 6e-09 Identities = 42/111 (37%), Positives = 53/111 (47%), Gaps = 1/111 (0%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E L+ L A D GR ALH AC G C +LL AGA + D++ Sbjct: 125 SRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKR 183 Query: 469 PLHYAAGYGRKECVDLLLKHGAAV-MLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH G G EC +LLL+ GA V + +TP+ VA E+ LL Sbjct: 184 PLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 234 Score = 47.0 bits (110), Expect = 5e-05 Identities = 36/113 (31%), Positives = 47/113 (41%), Gaps = 16/113 (14%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEI----------------LL 515 +G E L GA D + EG L AC +++C I LL Sbjct: 225 LGHVELADLLLRRGACPDARNAEGWTPLLAAC---DVRCQSITDAEATTARCLQLCSLLL 281 Query: 514 EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 AGA DA D++K PLH A G V+LLL G + + G TP+ A Sbjct: 282 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 334
>CSKI1_MOUSE (Q6P9K8) Caskin-1 (CASK-interacting protein 1)| Length = 1431 Score = 69.7 bits (169), Expect = 7e-12 Identities = 47/130 (36%), Positives = 69/130 (53%), Gaps = 5/130 (3%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + +D +G ALH A G + +LLEA AAVD D PLHYAA GRKE + L Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID-----PKTL 257 +LK G+AV + + +G P+ +A + +V ++L Q S+P ++D P L Sbjct: 101 VLKAGSAVNVPSDEGHIPLHLAAQHGHYDVSEMLLQ------HQSNPCMVDNSGKTPLDL 154 Query: 256 PCFWSLSGVM 227 C + GV+ Sbjct: 155 ACEFGRVGVV 164 Score = 60.8 bits (146), Expect = 3e-09 Identities = 35/108 (32%), Positives = 62/108 (57%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E + L+ A D +D +G R LH+A G + +++L+AG+AV+ + PL Sbjct: 60 GNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNVPSDEGHIPL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA +G + ++LL+H + + + GKTP+++A + VV+LL Sbjct: 120 HLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167 Score = 47.4 bits (111), Expect = 4e-05 Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 8/118 (6%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L G+ + EG LH A +G +E+LL+ + +D + TPL Sbjct: 93 GRKEPMKLVLKAGSAVNVPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPL 152 Query: 463 HYAAGYGRKECVDLLLKHGAAVML--------QNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A +GR V LLL L + +G +P+ +A N ++++LL Q Sbjct: 153 DLACEFGRVGVVQLLLSSNMCAALLEPRPGDTTDPNGTSPLHLAAKNGHIDIIRLLLQ 210 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 8/97 (8%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAV--------DALDKNKNTPLHYAAGYGRKEC 431 D G+ L AC +G + ++LL + D D N +PLH AA G + Sbjct: 145 DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDTTDPNGTSPLHLAAKNGHIDI 204 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LLL+ G + Q G T + A L + EVV+LL Sbjct: 205 IRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240 Score = 44.3 bits (103), Expect = 3e-04 Identities = 28/94 (29%), Positives = 45/94 (47%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D G LH A G + +LL+AG ++ K+ T LH AA G+ E V LLL Sbjct: 183 DTTDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKS-GTALHEAALCGKTEVVRLLL 241 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 G ++N +T +++ + + K ++Q Sbjct: 242 DSGINAQVRNTYSQTALDIVHQFTTSQASKEIKQ 275
>ANKR5_HUMAN (Q9NU02) Ankyrin repeat domain-containing protein 5| Length = 776 Score = 69.3 bits (168), Expect = 9e-12 Identities = 43/130 (33%), Positives = 70/130 (53%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ + +K L+ GAN + D LHFAC G+ E+L+E+GA +DA N +TPL Sbjct: 536 GNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPL 595 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 + A R + V LL GA L+N G + ++VAK + ++ L+++ + KP++ Sbjct: 596 NRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAE 655 Query: 283 PVLIDPKTLP 254 + KT P Sbjct: 656 NQKLKGKTPP 665 Score = 65.9 bits (159), Expect = 1e-10 Identities = 38/108 (35%), Positives = 59/108 (54%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD LKKA + G D +D + L AC G + + LLE GA V+A D TPL Sbjct: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+A G+++ V+LL++ GA + +++ TP+ A + + + VK L Sbjct: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610 Score = 54.7 bits (130), Expect = 2e-07 Identities = 40/135 (29%), Positives = 60/135 (44%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L+ G + D + A HFA G ++L V + N NTPL Sbjct: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 HYAA G +C + + G + +NLD KTP VAK K + + + +K + Sbjct: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLAR 315 Query: 283 PVLIDPKTLPCFWSL 239 P +P L W+L Sbjct: 316 PGAKNPNPL---WAL 327 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 1/102 (0%) Frame = -3 Query: 616 LDGGANKDE-EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 L+ GAN + GR AL A G ++ +LE G V+A D +++ H+AA G Sbjct: 171 LEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGF 230 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 + + LL + V L +++G TP+ A + + K + Q Sbjct: 231 FDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
>ANR28_HUMAN (O15084) Ankyrin repeat domain-containing protein 28| Length = 1086 Score = 69.3 bits (168), Expect = 9e-12 Identities = 43/108 (39%), Positives = 55/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L GAN + D + RRA+H+A G ++ ++L+ GA V DK TPL Sbjct: 184 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPL 243 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G V LL G + N G TP+ VA N QD VV L Sbjct: 244 HAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 291 Score = 64.3 bits (155), Expect = 3e-10 Identities = 33/115 (28%), Positives = 59/115 (51%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 L+ + GA+ + + +G+ LH +G ++ ++++GA +D DKN NTPLH AA Sbjct: 322 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 381 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 YG + ++ L+ GA + + G P+ +A L+ + + L F P D Sbjct: 382 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 436 Score = 61.6 bits (148), Expect = 2e-09 Identities = 34/80 (42%), Positives = 45/80 (56%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D +D G+ L + G C LL GA VDA DK T LH A G +ECVD LL Sbjct: 680 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 739 Query: 415 KHGAAVMLQNLDGKTPIEVA 356 +HGA +L++ G+TPI ++ Sbjct: 740 QHGAKCLLRDSRGRTPIHLS 759 Score = 60.8 bits (146), Expect = 3e-09 Identities = 35/95 (36%), Positives = 49/95 (51%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 +N + D GR ALH A G + ++LL GA ++A DK +H+AA G E V Sbjct: 164 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ HGA V ++ TP+ A + VVK L Sbjct: 224 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 258 Score = 60.1 bits (144), Expect = 6e-09 Identities = 36/102 (35%), Positives = 51/102 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ +K L G + D D GR LH A G L+C +LL GA + DK +PL Sbjct: 416 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 475 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQD 338 HYAA +C+ L+ GA+V + G TP+ A + D Sbjct: 476 HYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 517 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/104 (33%), Positives = 57/104 (54%), Gaps = 1/104 (0%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G +K LD G + +E + G LH AC G+ L++ GA V+ ++ T Sbjct: 248 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 307 Query: 469 PLHYAAGYGRKE-CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 PLH+AA C++LL+ +GA V +++ DGKTP+ + L+ + Sbjct: 308 PLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 351 Score = 58.9 bits (141), Expect = 1e-08 Identities = 46/137 (33%), Positives = 56/137 (40%), Gaps = 34/137 (24%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEA-------------------- 509 L+ A AN D G ALH+AC G C E+LLE Sbjct: 772 LQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVIN 831 Query: 508 ---GAA-----------VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKT 371 GAA V+A D TPLH AA EC+ LLL H A V + GKT Sbjct: 832 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 891 Query: 370 PIEVAKLNSQDEVVKLL 320 P+ +A N Q V++L Sbjct: 892 PLMMAAENGQTNTVEML 908 Score = 57.4 bits (137), Expect = 4e-08 Identities = 33/99 (33%), Positives = 54/99 (54%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + ++ + + + +D E R LH A G+ + E+L+ +GA V+A D TPL Sbjct: 52 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 111 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLN 347 H A +E V +LLKH A V ++ + +TP+ +A N Sbjct: 112 HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAAN 150 Score = 55.5 bits (132), Expect = 1e-07 Identities = 35/109 (32%), Positives = 57/109 (52%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +GDAE ++ + GA + +D + LH A + ++LL+ A V+A DKN TP Sbjct: 84 LGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTP 143 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA +C + L+ + V + + G+T + A + E+VKLL Sbjct: 144 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 192 Score = 53.9 bits (128), Expect = 4e-07 Identities = 28/83 (33%), Positives = 49/83 (59%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +G + E+L+++ +D + + TPL AA G ECVD+L+ GA++++++ Sbjct: 587 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 646 Query: 385 -LDGKTPIEVAKLNSQDEVVKLL 320 + +TPI A N E ++LL Sbjct: 647 YILKRTPIHAAATNGHSECLRLL 669 Score = 52.8 bits (125), Expect = 9e-07 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 4/109 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKN-KNTP 467 G + L+ + + D + GR L A G ++C ++L+ GA++ D K TP Sbjct: 594 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTP 653 Query: 466 LHYAAGYGRKECVDLLLKHGA---AVMLQNLDGKTPIEVAKLNSQDEVV 329 +H AA G EC+ LL+ + AV +Q+ +G+TP+ ++ LN + V Sbjct: 654 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 702 Score = 52.4 bits (124), Expect = 1e-06 Identities = 31/105 (29%), Positives = 57/105 (54%), Gaps = 2/105 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACG--YGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 + + +D GA ++++ +G LHFA +G L C E+L+ GA V+ K+ TPLH Sbjct: 288 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMT 346 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A +GR +++ GA + ++ +G TP+ +A + ++ L Sbjct: 347 ALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 391 Score = 52.0 bits (123), Expect = 2e-06 Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 5/118 (4%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + + L+ GAN D +D GR ALH G +C + LL+ GA D TP+ Sbjct: 697 GHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 756 Query: 463 HYAAGYGRKECVDLLLKHGAAV----MLQNLDGKTPIEVAKLNSQDEVVK-LLEQDVF 305 H +A G + LL+ A++ + G T + A N + V+ LLEQ+VF Sbjct: 757 HLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 814 Score = 50.4 bits (119), Expect = 4e-06 Identities = 31/119 (26%), Positives = 58/119 (48%), Gaps = 12/119 (10%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEIL--------LEAGAAVDALD 485 D + L+ L AN D +G A+H++ YG C +++ L + D L Sbjct: 517 DGKCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLS 576 Query: 484 KNKN----TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + N +PLH AA +G + +++L++ + ++N G+TP+++A E V +L Sbjct: 577 DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 635 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/90 (33%), Positives = 43/90 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 + GA+ + + G LH A G C LL +G +D D T LH AA G Sbjct: 392 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 451 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLN 347 EC++LLL GA ++ G++P+ A N Sbjct: 452 ECLNLLLNTGADFNKKDKFGRSPLHYAAAN 481 Score = 50.1 bits (118), Expect = 6e-06 Identities = 35/105 (33%), Positives = 49/105 (46%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E ++ L A+ + D + LH A +KCAE L+ + V+ D+ T LH+A Sbjct: 121 EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 180 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G E V LLL GA + + + I A EVVKLL Sbjct: 181 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 225 Score = 44.3 bits (103), Expect = 3e-04 Identities = 30/101 (29%), Positives = 51/101 (50%), Gaps = 4/101 (3%) Frame = -3 Query: 646 VGDAEGLKKALD---GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNK 476 + D EG + L G + + D +GR LH A ++C ++LL A V+++D Sbjct: 830 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTG 889 Query: 475 NTPLHYAAGYGRKECVDLLLKHGAA-VMLQNLDGKTPIEVA 356 TPL AA G+ V++L+ +A + LQ+ T + +A Sbjct: 890 KTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 930 Score = 40.4 bits (93), Expect = 0.005 Identities = 30/99 (30%), Positives = 40/99 (40%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 + GA D ED G LH A YG L+ +GA + PLH AA G Sbjct: 359 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 418 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +C LL G + + G+T + A E + LL Sbjct: 419 DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 457 Score = 39.7 bits (91), Expect = 0.008 Identities = 22/60 (36%), Positives = 33/60 (55%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V+ D K TPLH AA G E ++LL+ GA V ++ TP+ A + +E V++L Sbjct: 67 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 126 Score = 38.9 bits (89), Expect = 0.013 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 3/77 (3%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEA---GAAVDALDKNKNTPLHYAAGYGRKECVDLL 419 +D ALH AC G A ++LE ++A + TPLH AA G V L Sbjct: 919 QDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQEL 978 Query: 418 LKHGAAVMLQNLDGKTP 368 L GA+V+ + +G TP Sbjct: 979 LGKGASVLAVDENGYTP 995
>ANKR5_MOUSE (Q9D2J7) Ankyrin repeat domain-containing protein 5| Length = 775 Score = 68.2 bits (165), Expect = 2e-11 Identities = 38/108 (35%), Positives = 61/108 (56%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD LKKA++ G D +D + L AC G + + L+E GA V+A D TPL Sbjct: 503 GDLASLKKAIETGIPVDMKDNTYKTPLMIACASGNIDVVKFLIEKGANVNATDNFLWTPL 562 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+A G+++ V+LL+K GA++ +++ TP+ A + + + VK L Sbjct: 563 HFACHAGQQDIVELLVKAGASIDATSINNSTPLSRAIESCRLDTVKYL 610 Score = 62.0 bits (149), Expect = 1e-09 Identities = 34/110 (30%), Positives = 60/110 (54%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ + +K ++ GAN + D LHFAC G+ E+L++AGA++DA N +TPL Sbjct: 536 GNIDVVKFLIEKGANVNATDNFLWTPLHFACHAGQQDIVELLVKAGASIDATSINNSTPL 595 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A R + V LL GA ++N G +++AK + ++ ++++ Sbjct: 596 SRAIESCRLDTVKYLLDMGAKFQIENRKGHAAMDIAKAYADYRIIDMIKE 645 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/97 (29%), Positives = 46/97 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L+ G + D + A HFA G ++L + + + NTPL Sbjct: 196 GVLEIVRGILERGGEVNAYDNDRHHAAHFAAKGGFFDILKLLFAYNGDMGLIGMDGNTPL 255 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 H+AA G +C + + G + +NL+ KTP VAK Sbjct: 256 HFAAMGGFADCCKYIAQRGCDLKWKNLEHKTPRVVAK 292 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 1/102 (0%) Frame = -3 Query: 616 LDGGANKDEEDVE-GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 L+ GAN + + GR AL + G L+ +LE G V+A D +++ H+AA G Sbjct: 171 LEKGANPNAINTSTGRTALMESSREGVLEIVRGILERGGEVNAYDNDRHHAAHFAAKGGF 230 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 + + LL + + L +DG TP+ A + + K + Q Sbjct: 231 FDILKLLFAYNGDMGLIGMDGNTPLHFAAMGGFADCCKYIAQ 272 Score = 37.4 bits (85), Expect = 0.039 Identities = 25/82 (30%), Positives = 37/82 (45%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 + F G+L + +E G VD D TPL A G + V L++ GA V + Sbjct: 496 ISFITKAGDLASLKKAIETGIPVDMKDNTYKTPLMIACASGNIDVVKFLIEKGANVNATD 555 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 TP+ A Q ++V+LL Sbjct: 556 NFLWTPLHFACHAGQQDIVELL 577
>LCTA_LATMA (Q9XZC0) Alpha-latrocrustotoxin (Alpha-LCT) (Crusta1)| Length = 1395 Score = 67.8 bits (164), Expect = 3e-11 Identities = 39/114 (34%), Positives = 62/114 (54%), Gaps = 1/114 (0%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 + G+++ +K L+ GA D+E G ALH A + + L+ GA ++A + +T Sbjct: 725 ATGNSQIVKTILNSGAVVDQETANGFTALHLAIMNPNTETPQFLIAKGANINAKTNDGST 784 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQD 311 PLH+AA G+ LL+ GA + +NL + PI A +N +VK L+EQD Sbjct: 785 PLHFAAALGKTNIFQLLMDKGANIKAENLINQMPIHEAVVNGHLAIVKMLIEQD 838 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/114 (27%), Positives = 57/114 (50%), Gaps = 1/114 (0%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAV-DALDKNKN 473 ++G + +D GAN E++ + +H A G L ++L+E +++ +A + Sbjct: 791 ALGKTNIFQLLMDKGANIKAENLINQMPIHEAVVNGHLAIVKMLIEQDSSLMNAKNMRDE 850 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 P + AA K+ + L GA V +N DG T + + +N + EVV+ L Q+ Sbjct: 851 YPFYLAAEKRYKDVFNYLESKGADVNEKNNDGNTLLHLFSINGEVEVVQFLIQN 904 Score = 43.1 bits (100), Expect = 7e-04 Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 2/104 (1%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAG 449 +K +D GA GR+++H + G A +LL + ++ DKN TPLH A+ Sbjct: 461 RKLIDSGAQVGASFEMGRKSIHASATAGNDDVARLLLAKNNGLLNVPDKNGYTPLHIASE 520 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGK-TPIEVAKLNSQDEVVKLL 320 + V LL+ GA V ++ + TP+ +A +VK L Sbjct: 521 RKNNDFVKFLLEKGADVNVRTFANELTPLHLAARQDFTIIVKTL 564 Score = 42.7 bits (99), Expect = 0.001 Identities = 26/98 (26%), Positives = 48/98 (48%), Gaps = 1/98 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN + + +G LHFA G+ ++L++ GA + A + P+H A G V Sbjct: 772 GANINAKTNDGSTPLHFAAALGKTNIFQLLMDKGANIKAENLINQMPIHEAVVNGHLAIV 831 Query: 427 DLLLKHGAAVM-LQNLDGKTPIEVAKLNSQDEVVKLLE 317 +L++ +++M +N+ + P +A +V LE Sbjct: 832 KMLIEQDSSLMNAKNMRDEYPFYLAAEKRYKDVFNYLE 869 Score = 33.5 bits (75), Expect = 0.56 Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 4/92 (4%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAV--DALDKNKNTPLHYAAGYGRKECVDLLL-KHG 407 G LH A L A++L+++ V + +D N TPLHYA+ G E V + G Sbjct: 612 GLTPLHLAVLQNNLSAAKVLVKSNKKVKLNEMDNNGMTPLHYASMLGNLEFVKYFTSEQG 671 Query: 406 AAVMLQ-NLDGKTPIEVAKLNSQDEVVKLLEQ 314 V + + TP+ +A L + +V + L Q Sbjct: 672 IDVNAKTKVKNWTPLHLAILFKKFDVAQSLLQ 703 Score = 32.3 bits (72), Expect = 1.3 Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 1/121 (0%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAA 452 L + GA+ +++ V G L A G+ + L+E V+ +K + TPLH AA Sbjct: 1076 LNYLIRNGADPNKK-VRGDPPLFIAAMIGQYDIVKSLVEQHKIDVNTRNKEQFTPLHAAA 1134 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLI 272 + V L++ GA V + + PI++A S+ ++ L + F PS I Sbjct: 1135 SNDHIDVVKYLIQKGADVNAKGDENLKPIDLAGEKSK-AYLRSLGRRFFRNESPSKSFEI 1193 Query: 271 D 269 D Sbjct: 1194 D 1194 Score = 32.0 bits (71), Expect = 1.6 Identities = 23/96 (23%), Positives = 38/96 (39%), Gaps = 2/96 (2%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + ++ G LH + ++ E A ++ + TPLH A Sbjct: 569 GIDVNAKERAGFTPLHLSITSNSRAARTLINETPAGINIKSNSGLTPLHLAVLQNNLSAA 628 Query: 427 DLLLKHGAAVMLQNLD--GKTPIEVAKLNSQDEVVK 326 +L+K V L +D G TP+ A + E VK Sbjct: 629 KVLVKSNKKVKLNEMDNNGMTPLHYASMLGNLEFVK 664 Score = 30.8 bits (68), Expect = 3.6 Identities = 18/79 (22%), Positives = 36/79 (45%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ +E++ +G LH GE++ + L++ GA +K + + A +G V Sbjct: 872 GADVNEKNNDGNTLLHLFSINGEVEVVQFLIQNGADFRLRNKERKSFFDLAVEFGHAGIV 931 Query: 427 DLLLKHGAAVMLQNLDGKT 371 ++ + + GKT Sbjct: 932 GYAIEENKVDLQEPYRGKT 950
>PSD10_HUMAN (O75832) 26S proteasome non-ATPase regulatory subunit 10 (26S| proteasome regulatory subunit p28) (Gankyrin) Length = 226 Score = 67.4 bits (163), Expect = 4e-11 Identities = 37/88 (42%), Positives = 50/88 (56%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+GGAN D +D A+H A G LK ILL A+ + D NTPLH A R Sbjct: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 E LL+ GA++ ++N + KTP++VAK Sbjct: 186 EEAKLLVSQGASIYIENKEEKTPLQVAK 213 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/89 (39%), Positives = 47/89 (52%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D + R ALH+AC G + E LL+ G V+ D +PLH AA GR E V LL G Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V N +G TP+ A ++ E+ +L Sbjct: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVML 125 Score = 58.5 bits (140), Expect = 2e-08 Identities = 37/110 (33%), Positives = 56/110 (50%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E +K L GA + + G LH+A + A +LLE GA DA D + T Sbjct: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +H AA G + + +LL + A+ +Q+ +G TP+ +A + E KLL Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 Score = 51.6 bits (122), Expect = 2e-06 Identities = 35/101 (34%), Positives = 50/101 (49%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E ++ L G +++D G LH A G + + LL GA V+A+++N T Sbjct: 49 SAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCT 108 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLN 347 PLHYAA R E +LL+ GA N D K E ++ Sbjct: 109 PLHYAASKNRHEIAVMLLEGGA-----NPDAKDHYEATAMH 144 Score = 40.0 bits (92), Expect = 0.006 Identities = 25/74 (33%), Positives = 39/74 (52%) Frame = -3 Query: 541 ELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 ELK E +L + D++ T LH+A G E V+ LL+ G V ++ G +P+ Sbjct: 21 ELK--ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLH 78 Query: 361 VAKLNSQDEVVKLL 320 +A +DE+VK L Sbjct: 79 IAASAGRDEIVKAL 92 Score = 37.7 bits (86), Expect = 0.030 Identities = 18/52 (34%), Positives = 30/52 (57%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 A+ + +D EG LH AC ++ A++L+ GA++ +K + TPL A G Sbjct: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKG 214
>ANK2_HUMAN (Q01484) Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin,| nonerythroid) Length = 3924 Score = 67.4 bits (163), Expect = 4e-11 Identities = 36/99 (36%), Positives = 53/99 (53%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ D ++ G ALH A G+++ LL GA VDA + + TPLH A+ G+ Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E V LLL+H A +G TP+ ++ Q +V +L Sbjct: 511 EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549 Score = 65.1 bits (157), Expect = 2e-10 Identities = 37/102 (36%), Positives = 58/102 (56%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD AN + + G LH AC +K E+L++ GA++ A+ ++ TP+H AA Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G V LLL++GA+ + N+ G+T + +A Q EVV+ L Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483 Score = 65.1 bits (157), Expect = 2e-10 Identities = 36/86 (41%), Positives = 46/86 (53%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A YG + A +LL GAAVD +N TPLH A+ G V LLL G + Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 + DG TP+ A + D+VV+LL Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELL 318 Score = 63.5 bits (153), Expect = 5e-10 Identities = 37/97 (38%), Positives = 50/97 (51%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA++D G L AC YG +K LL+ GA V+A KN TPLH AA G + Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHII 777 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 ++LL+HGA +G T + +AK VV L+ Sbjct: 778 NVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 814 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/108 (34%), Positives = 54/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + L+ GA +G LH A YG L A++LL+ AA D+ KN TPL Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA Y ++ LLL+ GA+ +G TP+ +A +Q ++ L Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/108 (34%), Positives = 60/108 (55%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ + + + L GG + + + G ALH A G + + LL G++VD+ K NT L Sbjct: 42 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 101 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A+ G+ E V +L+K GA + Q+ +G TP+ +A + +VVK L Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149 Score = 60.1 bits (144), Expect = 6e-09 Identities = 39/109 (35%), Positives = 52/109 (47%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E ++ L A+ D G LH + G++ A +LLEAGAA K TP Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG + LLL+ AA +G TP+ VA +V LL Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615 Score = 58.9 bits (141), Expect = 1e-08 Identities = 39/116 (33%), Positives = 57/116 (49%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA D G LH A G ++LL+ G +DA ++ TPLH AA G Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 + V+LLL+ GA ++ + +G +P+ +A E VK L Q P D V +D Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH----KAPVDDVTLD 364 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/108 (38%), Positives = 52/108 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ +K LD G D + +G LH A G + E+LLE GA + A KN +PL Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA ECV LL+H A V LD T + VA V KLL Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384 Score = 57.8 bits (138), Expect = 3e-08 Identities = 37/108 (34%), Positives = 48/108 (44%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + K L A D G LH A Y K A +LLE GA+ A KN TPL Sbjct: 574 GSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA + + LL +GA + G TP+ +A ++V LL Sbjct: 634 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681 Score = 57.4 bits (137), Expect = 4e-08 Identities = 39/110 (35%), Positives = 54/110 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L GA D E + LH A G+ + ++LL+ A DA N TPL Sbjct: 475 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H +A G+ + +LL+ GAA L G TP+ VA +V KLL Q Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584 Score = 56.6 bits (135), Expect = 6e-08 Identities = 37/110 (33%), Positives = 52/110 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + + LD GAN G +LH A ++ A+IL + GA DA K TPL Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A YG + V+ LLK GA V + +G TP+ A ++ +L Q Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782 Score = 55.5 bits (132), Expect = 1e-07 Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 1/107 (0%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +++ L G++ D +G ALH A G+ + ++L++ GA ++A +N TPL+ AA Sbjct: 80 VQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQD 311 + V LL++GA DG TP+ VA ++ V LLE D Sbjct: 140 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/108 (33%), Positives = 54/108 (50%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K L A D+ ++ ALH A G + ++LL+ A +A N TPLH A Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 R + ++LL+K+GA++ G TPI VA +V LL Q+ Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453 Score = 52.4 bits (124), Expect = 1e-06 Identities = 33/98 (33%), Positives = 50/98 (51%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ G +H A G L +LL+ GA+ D + T LH AA G+ E V Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LL++GA V + + +TP+ +A + E+V+LL Q Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518 Score = 48.5 bits (114), Expect = 2e-05 Identities = 30/99 (30%), Positives = 45/99 (45%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ G LH A +++ A LL GA + + K TPLH A+ G Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V LLL GA + + G T + +A + V +L Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714 Score = 42.4 bits (98), Expect = 0.001 Identities = 29/87 (33%), Positives = 39/87 (44%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA + +G LH A G +LL+ GA + K+ T LH AA + Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVA 356 D+L KHGA G TP+ VA Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVA 735 Score = 35.4 bits (80), Expect = 0.15 Identities = 23/78 (29%), Positives = 36/78 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G AE +K + GAN + + G L+ A + + LLE GA ++ TPL Sbjct: 108 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPL 167 Query: 463 HYAAGYGRKECVDLLLKH 410 A G + V +LL++ Sbjct: 168 AVALQQGHNQAVAILLEN 185
>KRIT1_MOUSE (Q6S5J6) Krev interaction trapped protein 1 (Krev interaction| trapped 1) (Cerebral cavernous malformations 1 protein homolog) Length = 736 Score = 66.6 bits (161), Expect = 6e-11 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 5/129 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTP 467 GD+E L LD G + ++ D + +H+AC YG+++ ILLE G + L+ ++P Sbjct: 299 GDSELLSHLLDKGLSVNQLDNDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSP 358 Query: 466 LHYAAGYGRKECVDLLLKH-GAAVMLQNLDGKTPIEVAKLNSQ---DEVVKLLEQDVFL* 299 LH+AAG G E V +LL H + + G++P+ V + N Q +E KLL+ + Sbjct: 359 LHFAAGGGHAEIVQILLTHPDIDRHITDQQGRSPLNVCEENKQNNWEEAAKLLKDAI--- 415 Query: 298 SKPSDPVLI 272 +KP + V I Sbjct: 416 NKPYEKVRI 424 Score = 41.2 bits (95), Expect = 0.003 Identities = 26/83 (31%), Positives = 41/83 (49%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA-VMLQ 389 LH G+ + LL+ G +V+ LD + P+HYA YG+ E +LL+ G L Sbjct: 292 LHRNACEGDSELLSHLLDKGLSVNQLDNDHWAPIHYACWYGKVEATRILLEKGKCNPNLL 351 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 N +P+ A E+V++L Sbjct: 352 NGQLSSPLHFAAGGGHAEIVQIL 374
>INVS_BRARE (Q8UVC1) Inversin| Length = 1021 Score = 66.2 bits (160), Expect = 8e-11 Identities = 39/108 (36%), Positives = 57/108 (52%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD L K + A +D ED GR L + L CAE+LL+AGA ++ D ++ T L Sbjct: 19 GDKNTLHKLITESALRDSEDQFGRTPLMYCVLADRLDCAEVLLKAGAGINKTDHSQRTAL 78 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G + LLL A L++L+ TP+ +A +S + + LL Sbjct: 79 HLAAQKGNVRFMKLLLSRHADWRLKDLEEMTPLHLASRHSSSKPLSLL 126 Score = 62.8 bits (151), Expect = 9e-10 Identities = 36/109 (33%), Positives = 59/109 (54%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + + + GGA D D++G ALH+A G + E+L+E G + + D+ TP Sbjct: 393 MGHRDVILTLIKGGARVDLVDIDGHSALHWAALGGNAEVCEVLMENGISPNLQDQAGRTP 452 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+ LL++H A +Q+ +G+T + + N + VKLL Sbjct: 453 LQCAAYAGYINCMALLIQHDADPNIQDKEGRTALHWSCNNGYLDAVKLL 501 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/92 (36%), Positives = 49/92 (53%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A G + +LLE G VD LD K+TPL A G ++ + L+K G Sbjct: 347 DKYGGTALHAAALSGHVSTVRLLLEQGGMVDPLDVMKHTPLFRACEMGHRDVILTLIKGG 406 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 A V L ++DG + + A L EV ++L ++ Sbjct: 407 ARVDLVDIDGHSALHWAALGGNAEVCEVLMEN 438 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/108 (31%), Positives = 53/108 (49%), Gaps = 2/108 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ +K L A+ +D+E LH A + K +LL+ A VD D+NK T Sbjct: 85 GNVRFMKLLLSRHADWRLKDLEEMTPLHLASRHSSSKPLSLLLKHMAPGEVDTQDRNKQT 144 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 LH++A Y E V LL+KH + + + + +GK P+ A N + Sbjct: 145 ALHWSAFYNHPEHVKLLIKHDSNIGIPDSEGKIPLHWAAHNKHPNATR 192 Score = 52.4 bits (124), Expect = 1e-06 Identities = 44/155 (28%), Positives = 69/155 (44%), Gaps = 6/155 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ L+ G D DV L AC G L++ GA VD +D + ++ L Sbjct: 361 GHVSTVRLLLEQGGMVDPLDVMKHTPLFRACEMGHRDVILTLIKGGARVDLVDIDGHSAL 420 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 H+AA G E ++L+++G + LQ+ G+TP++ A + LL Q +D Sbjct: 421 HWAALGGNAEVCEVLMENGISPNLQDQAGRTPLQCAAYAGYINCMALLIQ------HDAD 474 Query: 283 PVLIDPK-TLPCFWS-----LSGVMSWHGVGRFPS 197 P + D + WS L V G G FP+ Sbjct: 475 PNIQDKEGRTALHWSCNNGYLDAVKLLLGCGAFPN 509 Score = 49.3 bits (116), Expect = 1e-05 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 3/94 (3%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLE-AGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +D EGR LHFA G E+L G +V A D TPLH+AA G + V LLL+ Sbjct: 210 QDYEGRTPLHFAVADGNEAVVEVLTSYEGCSVTAYDNLFRTPLHWAALLGHAKIVHLLLE 269 Query: 412 HGAAVML-QNLDGKTPIEV-AKLNSQDEVVKLLE 317 + M+ + G TP+ A+ N D V L+ Sbjct: 270 RNKSGMIPSDSQGATPLHYGAQSNFADTVAVFLK 303 Score = 46.6 bits (109), Expect = 6e-05 Identities = 26/69 (37%), Positives = 40/69 (57%), Gaps = 2/69 (2%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALD--KNKNTPLHYAAGYGRKEC 431 A+ + +D EGR ALH++C G L ++LL GA + ++ + + TPL YA +E Sbjct: 473 ADPNIQDKEGRTALHWSCNNGYLDAVKLLLGCGAFPNHMEHTEERYTPLDYALLGEHQEL 532 Query: 430 VDLLLKHGA 404 LL+HGA Sbjct: 533 TQFLLEHGA 541 Score = 40.4 bits (93), Expect = 0.005 Identities = 26/86 (30%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 R LH+A G K +LLE + + D TPLHY A + V + LKH + Sbjct: 249 RTPLHWAALLGHAKIVHLLLERNKSGMIPSDSQGATPLHYGAQSNFADTVAVFLKHHSVR 308 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +L+G+T A ++V+K++ Sbjct: 309 DEPDLEGRTAFMWAAGKGSNDVIKIM 334 Score = 36.6 bits (83), Expect = 0.066 Identities = 23/82 (28%), Positives = 37/82 (45%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 +H A G+ L+ A D+ D+ TPL Y R +C ++LLK GA + + Sbjct: 12 VHAAAVNGDKNTLHKLITESALRDSEDQFGRTPLMYCVLADRLDCAEVLLKAGAGINKTD 71 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 +T + +A +KLL Sbjct: 72 HSQRTALHLAAQKGNVRFMKLL 93 Score = 29.6 bits (65), Expect = 8.1 Identities = 21/91 (23%), Positives = 37/91 (40%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLL--LK 413 D +G LH+ + L+ + D D T +AAG G + + ++ LK Sbjct: 279 DSQGATPLHYGAQSNFADTVAVFLKHHSVRDEPDLEGRTAFMWAAGKGSNDVIKIMLDLK 338 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + + G T + A L+ V+LL Sbjct: 339 KDIDINMTDKYGGTALHAAALSGHVSTVRLL 369
>ANK1_MOUSE (Q02357) Ankyrin-1 (Erythrocyte ankyrin)| Length = 1862 Score = 66.2 bits (160), Expect = 8e-11 Identities = 37/105 (35%), Positives = 57/105 (54%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD GA + + G LH AC ++ E+LL+ GA++DA+ ++ TPLH A+ Sbjct: 351 KVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFM 410 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 G V LL+ GA+ + N+ +TP+ +A EV K L Q+ Sbjct: 411 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 455 Score = 61.2 bits (147), Expect = 3e-09 Identities = 38/109 (34%), Positives = 55/109 (50%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G +K L+ GA+ + G LH A G + A LLE A+ + K TP Sbjct: 476 IGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTP 535 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG+ +LLL+H A +G TP+ VA ++ ++VKLL Sbjct: 536 LHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 584 Score = 58.5 bits (140), Expect = 2e-08 Identities = 37/108 (34%), Positives = 55/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ ++ LD GA + + LH A G ++ +EILL+ GA + A KN +P+ Sbjct: 246 GNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 305 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA +CV LLL++ A + LD TP+ VA V K+L Sbjct: 306 HMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVL 353 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/89 (38%), Positives = 48/89 (53%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G LH A YG+++ AE+LLE A +A KN TPLH A + + V LLL G + Sbjct: 531 KGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 590 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 +G TP+ +A +Q EV + L Q Sbjct: 591 PHSPAWNGYTPLHIAAKQNQIEVARSLLQ 619 Score = 56.6 bits (135), Expect = 6e-08 Identities = 37/107 (34%), Positives = 54/107 (50%), Gaps = 1/107 (0%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K L GA+ + +V+ LH A G + A+ LL+ A +A K+ TPLH AA Sbjct: 416 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAAR 475 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ-DEVVKLLEQD 311 G V LLL++GA+ L G TP+ A D + LLE++ Sbjct: 476 IGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKE 522 Score = 56.6 bits (135), Expect = 6e-08 Identities = 33/101 (32%), Positives = 52/101 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ + G LH A G + +LL+ GA ++ K++ TPLH AA G Sbjct: 222 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHV 281 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++LL HGA + + +G +PI +A + V+LL Q Sbjct: 282 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 322 Score = 55.1 bits (131), Expect = 2e-07 Identities = 33/85 (38%), Positives = 45/85 (52%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G D G LH A YG +K + LL+ A V+A K +PLH AA G + V Sbjct: 687 GVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 746 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAK 353 LLLK+GA+ + +G TP+ +AK Sbjct: 747 TLLLKNGASPNEVSSNGTTPLAIAK 771 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/108 (31%), Positives = 51/108 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + L AN + + G LH G + A++L++ G VDA + TPL Sbjct: 642 GHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVPVADVLIKHGVTVDATTRMGYTPL 701 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A+ YG + V LL+H A V + G +P+ A ++V LL Sbjct: 702 HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 749 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/99 (34%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L N D G LH A Y L A++LL GA+V+ +N TPLH A+ G Sbjct: 189 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 248 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V LLL GA + + D TP+ A N + ++L Sbjct: 249 IMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEIL 287 Score = 52.4 bits (124), Expect = 1e-06 Identities = 34/107 (31%), Positives = 49/107 (45%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L G + + E V+G LH A G + +LL A + +K+ TPLH Sbjct: 612 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLV 671 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 + G D+L+KHG V G TP+ VA ++VK L Q Sbjct: 672 SQEGHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQ 718 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/99 (32%), Positives = 47/99 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 LD GA + G +H A L C +LL+ A +D + + TPLH AA G Sbjct: 288 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHH 347 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL GA + L+G TP+ +A + V++LL Sbjct: 348 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELL 386 Score = 51.6 bits (122), Expect = 2e-06 Identities = 38/106 (35%), Positives = 51/106 (48%), Gaps = 3/106 (2%) Frame = -3 Query: 628 LKKALD---GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHY 458 L KALD G + + + G LH A G +K LL ++ K NT LH Sbjct: 21 LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHI 80 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G+ E V L+ +GA V Q+ G TP+ +A + EVVK L Sbjct: 81 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 126 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/83 (36%), Positives = 40/83 (48%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 ALH A + + A +LL+ D L K TPLH AA Y LLL GA+V Sbjct: 172 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 231 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 +G TP+ +A +V+LL Sbjct: 232 PQNGITPLHIASRRGNVIMVRLL 254 Score = 48.9 bits (115), Expect = 1e-05 Identities = 33/101 (32%), Positives = 48/101 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L A D+ ++ LH A G + A++LL+ GA ++ N TPLH A Sbjct: 321 LQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHI 380 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++LLLK GA++ G TP+ VA +VK L Q Sbjct: 381 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 421 Score = 47.8 bits (112), Expect = 3e-05 Identities = 33/99 (33%), Positives = 45/99 (45%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ D G LH A G L + LL+ GA+ + + TPLH AA G Sbjct: 387 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 446 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E LL++ A + D +TP+ A +VKLL Sbjct: 447 EVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLL 485 Score = 47.0 bits (110), Expect = 5e-05 Identities = 29/99 (29%), Positives = 47/99 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ A+ + G LH A + L ++LL G + + N TPLH AA + Sbjct: 552 LEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQI 611 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E LL++G + +++ G TP+ +A E+V LL Sbjct: 612 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALL 650 Score = 46.2 bits (108), Expect = 8e-05 Identities = 30/84 (35%), Positives = 42/84 (50%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G ALH A G+ + L+ GA V+A + TPL+ AA E V LL++GA Sbjct: 73 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 132 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVV 329 + DG TP+ VA + VV Sbjct: 133 QNVATEDGFTPLAVALQQGHENVV 156 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/103 (31%), Positives = 43/103 (41%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K L G + G LH A +++ A LL+ G + +A TPLH AA Sbjct: 581 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQ 640 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G E V LLL A L N G TP+ + V +L Sbjct: 641 EGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVPVADVL 683 Score = 42.4 bits (98), Expect = 0.001 Identities = 31/108 (28%), Positives = 47/108 (43%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E K L A + + + + LH A G ++LLE GA+ + +TPL Sbjct: 444 GHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPL 503 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G + LL+ A+ G TP+ VA + + +LL Sbjct: 504 HTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELL 551 Score = 36.2 bits (82), Expect = 0.087 Identities = 35/137 (25%), Positives = 56/137 (40%), Gaps = 29/137 (21%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +++ ++ GAN + + +G L+ A L+ + LLE GA + ++ TPL Sbjct: 85 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 144 Query: 463 HYAAGYGRKECVDLLLKHG---------------------AAVMLQN--------LDGKT 371 A G + V L+ +G AAV+LQN G T Sbjct: 145 AVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 204 Query: 370 PIEVAKLNSQDEVVKLL 320 P+ +A V +LL Sbjct: 205 PLHIAAHYENLNVAQLL 221
>ANK1_HUMAN (P16157) Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R)| Length = 1880 Score = 65.9 bits (159), Expect = 1e-10 Identities = 37/105 (35%), Positives = 57/105 (54%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD GA + + G LH AC ++ E+LL+ GA++DA+ ++ TPLH A+ Sbjct: 354 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 413 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 G V LL+ GA+ + N+ +TP+ +A EV K L Q+ Sbjct: 414 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 458 Score = 58.9 bits (141), Expect = 1e-08 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + L+ A++ +G LH A YG+++ AE+LLE A +A KN TPL Sbjct: 513 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 572 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H A + + V LLL G + +G TP+ +A +Q EV + L Q Sbjct: 573 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 622 Score = 58.5 bits (140), Expect = 2e-08 Identities = 36/109 (33%), Positives = 53/109 (48%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G +K L+ AN + G LH A G ++ LLE A+ + K TP Sbjct: 479 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 538 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG+ +LLL+ A +G TP+ VA ++ ++VKLL Sbjct: 539 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 587 Score = 58.5 bits (140), Expect = 2e-08 Identities = 37/108 (34%), Positives = 56/108 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ ++ LD GA + + + LH A G ++ +EILL+ GA + A KN +P+ Sbjct: 249 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 308 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA +CV LLL++ A + LD TP+ VA V K+L Sbjct: 309 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 356 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 1/107 (0%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K L GA+ + +V+ LH A G + A+ LL+ A V+A K+ TPLH AA Sbjct: 419 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 478 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDE-VVKLLEQD 311 G V LLL++ A L G TP+ +A E V+ LLE++ Sbjct: 479 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 525 Score = 56.6 bits (135), Expect = 6e-08 Identities = 33/101 (32%), Positives = 52/101 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ + G LH A G + +LL+ GA ++ K++ TPLH AA G Sbjct: 225 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV 284 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++LL HGA + + +G +PI +A + V+LL Q Sbjct: 285 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 325 Score = 56.2 bits (134), Expect = 8e-08 Identities = 32/75 (42%), Positives = 43/75 (57%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A YG +K + LL+ A V+A K +PLH AA G + V LLLK+GA+ Sbjct: 700 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 759 Query: 397 MLQNLDGKTPIEVAK 353 + DG TP+ +AK Sbjct: 760 NEVSSDGTTPLAIAK 774 Score = 55.8 bits (133), Expect = 1e-07 Identities = 35/108 (32%), Positives = 52/108 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G AE + L AN + + G LH G + A++L++ G VDA + TPL Sbjct: 645 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 704 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A+ YG + V LL+H A V + G +P+ A ++V LL Sbjct: 705 HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 752 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/99 (34%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L N D G LH A Y L A++LL GA+V+ +N TPLH A+ G Sbjct: 192 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 251 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V LLL GA + + D TP+ A N + ++L Sbjct: 252 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 290 Score = 53.1 bits (126), Expect = 7e-07 Identities = 35/107 (32%), Positives = 49/107 (45%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L G + + E V+G LH A G + +LL A + +K+ TPLH Sbjct: 615 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 674 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G D+L+KHG V G TP+ VA ++VK L Q Sbjct: 675 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 721 Score = 51.6 bits (122), Expect = 2e-06 Identities = 32/99 (32%), Positives = 47/99 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 LD GA + G +H A L C +LL+ A +D + + TPLH AA G Sbjct: 291 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 350 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL GA + L+G TP+ +A + V++LL Sbjct: 351 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 389 Score = 51.6 bits (122), Expect = 2e-06 Identities = 38/106 (35%), Positives = 51/106 (48%), Gaps = 3/106 (2%) Frame = -3 Query: 628 LKKALD---GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHY 458 L KALD G + + + G LH A G +K LL ++ K NT LH Sbjct: 24 LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHI 83 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G+ E V L+ +GA V Q+ G TP+ +A + EVVK L Sbjct: 84 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 129 Score = 50.1 bits (118), Expect = 6e-06 Identities = 34/99 (34%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ D G LH A G L + LL+ GA+ + + TPLH AA G Sbjct: 390 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 449 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E LL++ A V + D +TP+ A +VKLL Sbjct: 450 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 488 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/83 (36%), Positives = 40/83 (48%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 ALH A + + A +LL+ D L K TPLH AA Y LLL GA+V Sbjct: 175 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 234 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 +G TP+ +A +V+LL Sbjct: 235 PQNGITPLHIASRRGNVIMVRLL 257 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/97 (32%), Positives = 47/97 (48%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A D+ ++ LH A G + A++LL+ GA ++ N TPLH A ++ Sbjct: 328 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 387 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLLK GA++ G TP+ VA +VK L Q Sbjct: 388 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 424 Score = 47.0 bits (110), Expect = 5e-05 Identities = 29/99 (29%), Positives = 47/99 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ A+ + G LH A + L ++LL G + + N TPLH AA + Sbjct: 555 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 614 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E LL++G + +++ G TP+ +A E+V LL Sbjct: 615 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 653 Score = 46.2 bits (108), Expect = 8e-05 Identities = 30/84 (35%), Positives = 42/84 (50%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G ALH A G+ + L+ GA V+A + TPL+ AA E V LL++GA Sbjct: 76 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 135 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVV 329 + DG TP+ VA + VV Sbjct: 136 QNVATEDGFTPLAVALQQGHENVV 159 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/103 (31%), Positives = 43/103 (41%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K L G + G LH A +++ A LL+ G + +A TPLH AA Sbjct: 584 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ 643 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G E V LLL A L N G TP+ + V +L Sbjct: 644 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 686 Score = 43.5 bits (101), Expect = 5e-04 Identities = 33/108 (30%), Positives = 46/108 (42%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E K L A + + + + LH A G ++LLE A + +TPL Sbjct: 447 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 506 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G E V LL+ A+ G TP+ VA + V +LL Sbjct: 507 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 554 Score = 36.2 bits (82), Expect = 0.087 Identities = 35/137 (25%), Positives = 56/137 (40%), Gaps = 29/137 (21%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +++ ++ GAN + + +G L+ A L+ + LLE GA + ++ TPL Sbjct: 88 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 147 Query: 463 HYAAGYGRKECVDLLLKHG---------------------AAVMLQN--------LDGKT 371 A G + V L+ +G AAV+LQN G T Sbjct: 148 AVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 207 Query: 370 PIEVAKLNSQDEVVKLL 320 P+ +A V +LL Sbjct: 208 PLHIAAHYENLNVAQLL 224
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 65.9 bits (159), Expect = 1e-10 Identities = 41/110 (37%), Positives = 58/110 (52%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE + L GGA+ + G ALH A G L+ A++LL+ GA V+ D TPLH Sbjct: 112 NAELITSLLHGGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 171 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 AA YG ++ LLLK GA V + G P+ +A + KLL ++ Sbjct: 172 IAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEE 221 Score = 47.0 bits (110), Expect = 5e-05 Identities = 29/86 (33%), Positives = 41/86 (47%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A + LL GA + + T LH A G E D+LL+HGA V Sbjct: 100 GFTALHLAVYKDNAELITSLLHGGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV 159 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +Q+ TP+ +A ++V +LL Sbjct: 160 NIQDAVFFTPLHIAAYYGHEQVTRLL 185 Score = 45.4 bits (106), Expect = 1e-04 Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 2/113 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L GAN + +D LH A YG + +LL+ GA V+ + + PL Sbjct: 144 GHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPL 203 Query: 463 HYAAGYGRKECVDLLLKHG--AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 H A+ G LL++ G A V Q+ + P+ ++VK L Q+ Sbjct: 204 HLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQN 256 Score = 32.3 bits (72), Expect = 1.3 Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 2/81 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGE-LKCAEILLEAGAA-VDALDKNKNTPLHYAAGYG 443 + G + +E++ A H AC YG+ + + LL+ ++ ++ +T LH A +G Sbjct: 291 ISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHG 350 Query: 442 RKECVDLLLKHGAAVMLQNLD 380 V LL +GA + L D Sbjct: 351 HIHLVQFLLDNGADMNLVACD 371
>PSD10_MOUSE (Q9Z2X2) 26S proteasome non-ATPase regulatory subunit 10 (26S| proteasome regulatory subunit p28) (Gankyrin) Length = 231 Score = 65.9 bits (159), Expect = 1e-10 Identities = 36/88 (40%), Positives = 49/88 (55%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+GGAN D +D A+H A G LK ILL A+ + D NTPLH A R Sbjct: 126 LEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERV 185 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 E L+ GA++ ++N + KTP++VAK Sbjct: 186 EEAKFLVTQGASIYIENKEEKTPLQVAK 213 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/89 (39%), Positives = 47/89 (52%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D + R ALH+AC G + E LL+ G V+ D +PLH AA GR E V LL G Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKG 96 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V N +G TP+ A ++ E+ +L Sbjct: 97 AHVNAVNQNGCTPLHYAASKNRHEIAVML 125 Score = 55.8 bits (133), Expect = 1e-07 Identities = 37/110 (33%), Positives = 55/110 (50%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E +K L GA+ + + G LH+A + A +LLE GA DA D T Sbjct: 82 SAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDAT 141 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +H AA G + V +LL + A+ +Q+ +G TP+ +A + E K L Sbjct: 142 AMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKFL 191 Score = 50.8 bits (120), Expect = 3e-06 Identities = 31/82 (37%), Positives = 44/82 (53%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E ++ L G +++D G LH A G + + LL GA V+A+++N T Sbjct: 49 SAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCT 108 Query: 469 PLHYAAGYGRKECVDLLLKHGA 404 PLHYAA R E +LL+ GA Sbjct: 109 PLHYAASKNRHEIAVMLLEGGA 130 Score = 36.6 bits (83), Expect = 0.066 Identities = 18/52 (34%), Positives = 29/52 (55%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 A+ + +D EG LH AC ++ A+ L+ GA++ +K + TPL A G Sbjct: 163 ASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASIYIENKEEKTPLQVAKG 214
>PSD10_RAT (Q9Z2X3) 26S proteasome non-ATPase regulatory subunit 10 (26S| proteasome regulatory subunit p28) (Gankyrin) Length = 231 Score = 65.5 bits (158), Expect = 1e-10 Identities = 36/88 (40%), Positives = 50/88 (56%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+GGAN D ++ A+H A G LK ILL A+ + D NTPLH A R Sbjct: 126 LEGGANPDAKNHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERV 185 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 E LL+ GA++ ++N + KTP++VAK Sbjct: 186 EEAKLLVTQGASIYIENKEEKTPLQVAK 213 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/89 (38%), Positives = 46/89 (51%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D + R ALH+AC G + E LL+ G V+ D +PLH AA GR E V LL G Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNEKDDAGWSPLHIAASAGRDEIVKALLIKG 96 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V N +G T + A ++ E+ +L Sbjct: 97 AQVNAVNQNGCTALHYAASKNRHEIAVML 125 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E +K L GA + + G ALH+A + A +LLE GA DA + T Sbjct: 82 SAGRDEIVKALLIKGAQVNAVNQNGCTALHYAASKNRHEIAVMLLEGGANPDAKNHYDAT 141 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +H AA G + V +LL + A+ +Q+ +G TP+ +A + E KLL Sbjct: 142 AMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 Score = 49.7 bits (117), Expect = 8e-06 Identities = 36/110 (32%), Positives = 53/110 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E ++ L G +E+D G LH A G + + LL GA V+A+++N T Sbjct: 49 SAGHTEIVEFLLQLGVPVNEKDDAGWSPLHIAASAGRDEIVKALLIKGAQVNAVNQNGCT 108 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LHYAA R E +LL+ GA +N T + A ++V +L Sbjct: 109 ALHYAASKNRHEIAVMLLEGGANPDAKNHYDATAMHRAAAKGNLKMVHIL 158 Score = 40.4 bits (93), Expect = 0.005 Identities = 25/74 (33%), Positives = 39/74 (52%) Frame = -3 Query: 541 ELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 ELK E +L + D++ T LH+A G E V+ LL+ G V ++ G +P+ Sbjct: 21 ELK--ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNEKDDAGWSPLH 78 Query: 361 VAKLNSQDEVVKLL 320 +A +DE+VK L Sbjct: 79 IAASAGRDEIVKAL 92 Score = 37.4 bits (85), Expect = 0.039 Identities = 18/52 (34%), Positives = 30/52 (57%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 A+ + +D EG LH AC ++ A++L+ GA++ +K + TPL A G Sbjct: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVTQGASIYIENKEEKTPLQVAKG 214
>ANR50_HUMAN (Q9ULJ7) Ankyrin repeat domain-containing protein 50| Length = 1375 Score = 65.5 bits (158), Expect = 1e-10 Identities = 36/99 (36%), Positives = 54/99 (54%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + D EGR ALH +C G ++ ++L+ A V+A D K + L AA G Sbjct: 912 LENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 971 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V LL++HGA V G T + +A +VV++L Sbjct: 972 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1010 Score = 62.8 bits (151), Expect = 9e-10 Identities = 41/110 (37%), Positives = 54/110 (49%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G A + +D GA D D +G L A G + ++LLE GA VD D N T Sbjct: 670 SKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 729 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PL AA G V+ LL GAAV + +G+T + +A EVV+ L Sbjct: 730 PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 779 Score = 62.8 bits (151), Expect = 9e-10 Identities = 43/114 (37%), Positives = 58/114 (50%), Gaps = 5/114 (4%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFAC-----GYGELKCAEILLEAGAAVDALDK 482 +G E ++ LD GA + EDV+GR AL A G +L++ GA VD DK Sbjct: 633 MGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK 692 Query: 481 NKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + TPL AA G + VDLLL+ GA V + +G+TP+ A VV L Sbjct: 693 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 746 Score = 59.3 bits (142), Expect = 1e-08 Identities = 32/108 (29%), Positives = 55/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E ++ LD G +++ D G LH A G E L+E GA + +D + P Sbjct: 771 GNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 830 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A+ G +CV +LL++ + + + DG+ + VA L ++V+LL Sbjct: 831 ILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 878 Score = 53.9 bits (128), Expect = 4e-07 Identities = 36/98 (36%), Positives = 47/98 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + L G D D + R AL A G LL+ GA V+ D T L Sbjct: 568 GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 627 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKL 350 AA G +E V+ LL HGA V +++DG+T + VA L Sbjct: 628 IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAAL 665 Score = 51.6 bits (122), Expect = 2e-06 Identities = 34/96 (35%), Positives = 47/96 (48%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN + D +G AL A G + LL AG VD D + T L AA G ++ V Sbjct: 547 GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 606 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+HGA V + +G+T + A E+V+ L Sbjct: 607 LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 642 Score = 50.4 bits (119), Expect = 4e-06 Identities = 29/92 (31%), Positives = 46/92 (50%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 ++ GA +E D +GR A G C +ILLE + +D + L AA G + Sbjct: 813 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 872 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 + V+LL HGA V ++ DG+ + + L +Q Sbjct: 873 DIVELLFSHGADVNCKDADGRPTLYILALENQ 904 Score = 49.7 bits (117), Expect = 8e-06 Identities = 34/110 (30%), Positives = 50/110 (45%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S+G A + L GA D D EGR L A G ++ LL+ G + D T Sbjct: 736 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 795 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH AA G + + L++ GA + DG+ P +A + V++L Sbjct: 796 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 845 Score = 49.7 bits (117), Expect = 8e-06 Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 1/111 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + + L+GGA+ D D GR L A G LL GAAVD++D T L Sbjct: 705 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 764 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQ 314 A+ G E V LL G ++ G TP+ +A + + L+EQ Sbjct: 765 SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 815 Score = 41.6 bits (96), Expect = 0.002 Identities = 24/67 (35%), Positives = 37/67 (55%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 LL+ GA+V+ D N T L AA G + V+LL+ GA + +++ G TP+ +A Sbjct: 477 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 536 Query: 340 DEVVKLL 320 +VV L Sbjct: 537 TKVVNCL 543 Score = 39.7 bits (91), Expect = 0.008 Identities = 28/95 (29%), Positives = 47/95 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ ++ GA D +G AL A G + ++LLE GA + D+ T + Sbjct: 969 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAM 1028 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEV 359 AA G + + LL K+GA+ +L+G +P V Sbjct: 1029 RVAAKNGHSQIIKLLEKYGAS----SLNGCSPSPV 1059
>HECD1_HUMAN (Q9ULT8) E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing| protein 1) (E3 ligase for inhibin receptor) (EULIR) Length = 2612 Score = 65.1 bits (157), Expect = 2e-10 Identities = 40/109 (36%), Positives = 63/109 (57%), Gaps = 1/109 (0%) Frame = -3 Query: 640 DAEGLKKALDGGANK-DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 D + L A+D GA + + D G+ L++A +G + E L E GA V+ +++ L Sbjct: 374 DTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNR--GQRSSSL 431 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 HYAA +GR + LL+HGA L++ DGKTP++ A+ EVV +L+ Sbjct: 432 HYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQ 480 Score = 35.4 bits (80), Expect = 0.15 Identities = 20/54 (37%), Positives = 28/54 (51%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 +LH+A +G + A+ LL GA D D++ TPL A G E V +L G Sbjct: 430 SLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQSPG 483
>GABP2_MOUSE (Q00420) GA-binding protein beta chain (GABP-beta-2 subunit)| (GABP-2) (GABP-beta-1 subunit) (GABPB-1) Length = 383 Score = 64.3 bits (155), Expect = 3e-10 Identities = 36/86 (41%), Positives = 47/86 (54%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A YG E+LL AG + DA K TPLH AA G V++LLKHGA V Sbjct: 38 GTSPLHLAAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADV 97 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +++ T + A ++ EVV+LL Sbjct: 98 NAKDMLKMTALHWATEHNHQEVVELL 123 Score = 62.8 bits (151), Expect = 9e-10 Identities = 34/100 (34%), Positives = 55/100 (55%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G ++D R LH A G E+LL+ GA V+A D K T LH+A + + Sbjct: 58 LRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDMLKMTALHWATEHNHQ 117 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 E V+LL+K+GA V Q+ KT +++ N +++ ++L+ Sbjct: 118 EVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157 Score = 32.7 bits (73), Expect = 0.96 Identities = 19/67 (28%), Positives = 32/67 (47%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 +L A A D +PLH AA YG ++LL+ G + + +TP+ +A Sbjct: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83 Query: 340 DEVVKLL 320 +V++L Sbjct: 84 ANIVEVL 90
>UACA_HUMAN (Q9BZF9) Uveal autoantigen with coiled-coil domains and ankyrin| repeats protein Length = 1416 Score = 63.9 bits (154), Expect = 4e-10 Identities = 38/110 (34%), Positives = 54/110 (49%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G+ E L L G + D GR ALH A YG C + LL+ + D T Sbjct: 77 SKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRT 136 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA + LL HGA+V +++DG+TP+ +A S+ + +LL Sbjct: 137 ALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLL 186 Score = 53.1 bits (126), Expect = 7e-07 Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKAL-DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD E + L G N + DVEGR H G L+C +L G + D Sbjct: 45 GDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNA 104 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG C+ LL++ +L G+T + A + ++LL Sbjct: 105 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLL 153 Score = 42.7 bits (99), Expect = 0.001 Identities = 29/93 (31%), Positives = 44/93 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G A L+K L + D++GR ALH A ++L + GA+V+A D + TPL Sbjct: 112 GHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPL 171 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 A R LL+ GA V ++ +T + Sbjct: 172 VLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 204 Score = 36.2 bits (82), Expect = 0.087 Identities = 18/54 (33%), Positives = 28/54 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 +D GA+ + D + R AL C YG E+L++ GA + LD + +YA Sbjct: 187 IDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
>KRIT1_HUMAN (O00522) Krev interaction trapped protein 1 (Krev interaction| trapped 1) (Cerebral cavernous malformations 1 protein) Length = 736 Score = 63.9 bits (154), Expect = 4e-10 Identities = 41/129 (31%), Positives = 71/129 (55%), Gaps = 5/129 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTP 467 GD+E L + L + ++ D + +H+AC YG+++ ILLE G + L+ ++P Sbjct: 299 GDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSP 358 Query: 466 LHYAAGYGRKECVDLLLKHGAAVM-LQNLDGKTPIEVAKLNSQ---DEVVKLLEQDVFL* 299 LH+AAG G E V +LL H + + G++P+ + + N Q +E KLL++ + Sbjct: 359 LHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAI--- 415 Query: 298 SKPSDPVLI 272 +KP + V I Sbjct: 416 NKPYEKVRI 424 Score = 38.1 bits (87), Expect = 0.023 Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA-VMLQ 389 LH + G+ + LL +V+ LD + P+HYA YG+ E +LL+ G L Sbjct: 292 LHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLL 351 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 N +P+ A E+V++L Sbjct: 352 NGQLSSPLHFAAGGGHAEIVQIL 374
>KRIT1_BOVIN (Q6TNJ1) Krev interaction trapped protein 1 (Krev interaction| trapped 1) (Cerebral cavernous malformations 1 protein homolog) Length = 736 Score = 63.9 bits (154), Expect = 4e-10 Identities = 41/129 (31%), Positives = 72/129 (55%), Gaps = 5/129 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTP 467 GD+E L + L+ + ++ D + +H+AC YG+++ ILLE G + L+ ++P Sbjct: 299 GDSELLNRLLNERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSP 358 Query: 466 LHYAAGYGRKECVDLLLKHGAAVM-LQNLDGKTPIEVAKLNSQ---DEVVKLLEQDVFL* 299 LH+AAG G E V +LL H + + G++P+ + + N Q +E KLL++ + Sbjct: 359 LHFAAGGGHAEIVQILLNHPEIDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAI--- 415 Query: 298 SKPSDPVLI 272 +KP + V I Sbjct: 416 NKPYEKVRI 424 Score = 38.1 bits (87), Expect = 0.023 Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA-VMLQ 389 LH + G+ + LL +V+ LD + P+HYA YG+ E +LL+ G L Sbjct: 292 LHRSACEGDSELLNRLLNERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLL 351 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 N +P+ A E+V++L Sbjct: 352 NGQLSSPLHFAAGGGHAEIVQIL 374
>LITD_LATMA (Q25338) Delta-latroinsectotoxin precursor (Delta-LIT)| Length = 1214 Score = 63.9 bits (154), Expect = 4e-10 Identities = 39/110 (35%), Positives = 59/110 (53%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G +K+ L G+N +E+ EG +LH A E + A +L+E GA ++A + T Sbjct: 750 STGQINIIKELLKRGSNIEEKTGEGYTSLHIAAMRKEPEIAVVLIENGADIEARSADNLT 809 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH AA GRK V LL+ GA + + DG T + +A + + V+ L Sbjct: 810 PLHSAAKIGRKSTVLYLLEKGADIGAKTADGSTALHLAVSGRKMKTVETL 859 Score = 40.0 bits (92), Expect = 0.006 Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 3/102 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 ++ GA+ + + R A+H G K A L ++D K+KN TPLH AA G Sbjct: 489 IEKGADIEAKFDNDRSAMHAVAYRGNNKIALRFLLKNQSIDIELKDKNGFTPLHIAAEAG 548 Query: 442 RKECVDLLLKHGAAVMLQ-NLDGKTPIEVAKLNSQDEVVKLL 320 + V LL+ HGA V + + TP+ +A + + V+ L Sbjct: 549 QAGFVKLLINHGADVNAKTSKTNLTPLHLATRSGFSKTVRNL 590 Score = 38.1 bits (87), Expect = 0.023 Identities = 20/54 (37%), Positives = 28/54 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 L+ GA+ + +G ALH A ++K E LL GA + D NK P+H A Sbjct: 827 LEKGADIGAKTADGSTALHLAVSGRKMKTVETLLNKGANLKEYDNNKYLPIHKA 880 Score = 38.1 bits (87), Expect = 0.023 Identities = 27/109 (24%), Positives = 53/109 (48%), Gaps = 4/109 (3%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEIL--LEAGAAVDALDKNKN-TPL 464 E + ++ A+ + +DV +HFA G +K L ++ +++++ +N N TPL Sbjct: 652 EVAESLVESNADLNIQDVNHMAPIHFAASMGSIKMLRYLISIKDKVSINSVTENNNWTPL 711 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGK-TPIEVAKLNSQDEVVKLL 320 H+A + +++ LLK + DG T + +A Q ++K L Sbjct: 712 HFAIYFKKEDAAKELLKQDDINLTIVADGNLTVLHLAVSTGQINIIKEL 760 Score = 36.2 bits (82), Expect = 0.087 Identities = 26/101 (25%), Positives = 47/101 (46%), Gaps = 4/101 (3%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 +K+ + G H A + AE L+E+ A ++ D N P+H+AA G + + Sbjct: 630 DKNAQSTSGLTPFHLAIINESQEVAESLVESNADLNIQDVNHMAPIHFAASMGSIKMLRY 689 Query: 421 LLKHGAAVMLQNL---DGKTPIEVA-KLNSQDEVVKLLEQD 311 L+ V + ++ + TP+ A +D +LL+QD Sbjct: 690 LISIKDKVSINSVTENNNWTPLHFAIYFKKEDAAKELLKQD 730
>AKIB1_HUMAN (Q9P2G1) Ankyrin repeat and IBR domain-containing protein 1| (Fragment) Length = 1214 Score = 63.9 bits (154), Expect = 4e-10 Identities = 33/68 (48%), Positives = 44/68 (64%), Gaps = 1/68 (1%) Frame = -3 Query: 505 AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQDEVV 329 AA+DA+D KNTPLHYAA G K CV+LL+KHG + +N + TP + A K + +D + Sbjct: 261 AAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDTPCDCAEKQHHKDLAL 320 Query: 328 KLLEQDVF 305 L Q VF Sbjct: 321 NLESQMVF 328 Score = 32.0 bits (71), Expect = 1.6 Identities = 17/54 (31%), Positives = 27/54 (50%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKE 434 D D + LH+A G C E+L++ G + A ++NK+TP A K+ Sbjct: 264 DAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDTPCDCAEKQHHKD 317
>FANK1_BOVIN (Q6B858) Fibronectin type 3 and ankyrin repeat domains protein 1| (GV14) Length = 345 Score = 63.9 bits (154), Expect = 4e-10 Identities = 40/98 (40%), Positives = 57/98 (58%), Gaps = 2/98 (2%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TPL-HYAAGYGRKE 434 GA+ D D+ G ALH+A G E ++ G VDA+D TPL +A G +E Sbjct: 200 GASWDTRDMGGCTALHWAADGGHCNVIEWMIGDGCEVDAVDAGSRWTPLMRVSAVSGNQE 259 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ GA V +++ DGKTP+ VA LN+ +E+V+LL Sbjct: 260 VASLLIDAGADVNVKDKDGKTPLMVAVLNNHEELVQLL 297 Score = 52.0 bits (123), Expect = 2e-06 Identities = 29/77 (37%), Positives = 45/77 (58%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G + A +L++AGA V+ DK+ TPL A +E V LLL GA ++N GK + Sbjct: 256 GNQEVASLLIDAGADVNVKDKDGKTPLMVAVLNNHEELVQLLLDRGADASVKNEFGKGVL 315 Query: 364 EVAKLNSQDEVVKLLEQ 314 E+A++ + V+ LLE+ Sbjct: 316 EMARVFDRQNVLSLLEE 332 Score = 34.7 bits (78), Expect = 0.25 Identities = 25/70 (35%), Positives = 32/70 (45%) Frame = -3 Query: 523 ILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 IL VD +K T L AA G V +L+ HG V LQN GK + +A Sbjct: 129 ILQGGNVKVDVPNKFGFTALMVAAQRGYTRLVKILISHGTDVNLQNGSGKDSLMLACYAG 188 Query: 343 QDEVVKLLEQ 314 +VVK L + Sbjct: 189 HLDVVKYLRR 198
>GABP2_HUMAN (Q06547) GA-binding protein beta chain (GABP-beta-2 subunit)| (GABP-2) (GABP-beta-1 subunit) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2) Length = 395 Score = 63.9 bits (154), Expect = 4e-10 Identities = 36/86 (41%), Positives = 47/86 (54%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A YG E+LL AG + DA K TPLH AA G V++LLKHGA V Sbjct: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +++ T + A ++ EVV+LL Sbjct: 98 NAKDMLKMTALHWATEHNHQEVVELL 123 Score = 62.8 bits (151), Expect = 9e-10 Identities = 34/100 (34%), Positives = 55/100 (55%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G ++D R LH A G E+LL+ GA V+A D K T LH+A + + Sbjct: 58 LRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQ 117 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 E V+LL+K+GA V Q+ KT +++ N +++ ++L+ Sbjct: 118 EVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157 Score = 33.1 bits (74), Expect = 0.73 Identities = 19/67 (28%), Positives = 32/67 (47%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 +L A A D +PLH AA YG ++LL+ G + + +TP+ +A Sbjct: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83 Query: 340 DEVVKLL 320 +V++L Sbjct: 84 ASIVEVL 90
>AKIB1_MOUSE (Q6ZPS6) Ankyrin repeat and IBR domain-containing protein 1| (Fragment) Length = 1087 Score = 63.5 bits (153), Expect = 5e-10 Identities = 33/68 (48%), Positives = 43/68 (63%), Gaps = 1/68 (1%) Frame = -3 Query: 505 AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQDEVV 329 AA+DA+D KNTPLHYAA G K CV+LL+KHG + +N + TP + A K +D + Sbjct: 139 AAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENRDTPCDCAEKQQHKDLAL 198 Query: 328 KLLEQDVF 305 L Q VF Sbjct: 199 SLESQMVF 206 Score = 30.8 bits (68), Expect = 3.6 Identities = 16/54 (29%), Positives = 27/54 (50%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKE 434 D D + LH+A G C E+L++ G + A ++N++TP A K+ Sbjct: 142 DAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENRDTPCDCAEKQQHKD 195
>CTTB2_OTOGA (Q2QLG9) Cortactin-binding protein 2 (CortBP2)| Length = 1655 Score = 63.5 bits (153), Expect = 5e-10 Identities = 36/87 (41%), Positives = 49/87 (56%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G AL+ A G C +LL A A V+A DKN TPL AA G ECV+LL+ + A Sbjct: 734 DGHSALYSAAKNGHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDAH 793 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + +G+TP+ +A N E +KLL Sbjct: 794 INHAADEGQTPLYLACKNGNKECIKLL 820 Score = 51.2 bits (121), Expect = 3e-06 Identities = 31/108 (28%), Positives = 49/108 (45%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L+ A + D G L A G +C E+L+ A ++ TPL Sbjct: 746 GHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDAHINHAADEGQTPL 805 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A G KEC+ LLL+ G ++ DG TP+ + +KLL Sbjct: 806 YLACKNGNKECIKLLLEAGTNRNVKTRDGWTPVHAVVDTGDVDSLKLL 853 Score = 41.6 bits (96), Expect = 0.002 Identities = 22/71 (30%), Positives = 37/71 (52%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 EG+ L+ AC G +C ++LLEAG + ++ TP+H G + + LL+ H A Sbjct: 800 EGQTPLYLACKNGNKECIKLLLEAGTNRNVKTRDGWTPVHAVVDTGDVDSLKLLMYHRAP 859 Query: 400 VMLQNLDGKTP 368 +L+ + P Sbjct: 860 ARGNSLNEEEP 870 Score = 33.9 bits (76), Expect = 0.43 Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 L A G + +LL E G ++ ++ ++ L+ AA G +CV LLL A V Sbjct: 705 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVNAA 764 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +G TP+ A E V+LL Sbjct: 765 DKNGFTPLCAAAAQGHFECVELL 787
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 63.5 bits (153), Expect = 5e-10 Identities = 40/110 (36%), Positives = 57/110 (51%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE + L GA+ + G ALH A G L+ A++LL+ GA V+ D TPLH Sbjct: 214 NAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 273 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 AA YG ++ LLLK GA V + G P+ +A + KLL ++ Sbjct: 274 IAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEE 323 Score = 47.4 bits (111), Expect = 4e-05 Identities = 29/86 (33%), Positives = 42/86 (48%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A + LL +GA + + T LH A G E D+LL+HGA V Sbjct: 202 GFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV 261 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +Q+ TP+ +A ++V +LL Sbjct: 262 NIQDAVFFTPLHIAAYYGHEQVTRLL 287 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 2/112 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L GAN + +D LH A YG + +LL+ GA V+ + + PL Sbjct: 246 GHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPL 305 Query: 463 HYAAGYGRKECVDLLLKHG--AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H A+ G LL++ G A V Q+ + P+ ++VK L Q Sbjct: 306 HLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQ 357 Score = 32.3 bits (72), Expect = 1.3 Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 2/81 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGE-LKCAEILLEAGAA-VDALDKNKNTPLHYAAGYG 443 + G + +E++ A H AC YG+ + + LL+ ++ ++ +T LH A +G Sbjct: 393 ISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHG 452 Query: 442 RKECVDLLLKHGAAVMLQNLD 380 V LL +GA + L D Sbjct: 453 HIRLVQFLLDNGADMNLVACD 473
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 63.5 bits (153), Expect = 5e-10 Identities = 38/105 (36%), Positives = 57/105 (54%), Gaps = 1/105 (0%) Frame = -3 Query: 631 GLKKALDG-GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 GL K L G GA D + R LH A G+++ + LL+ GA DALD + +PLH A Sbjct: 516 GLVKLLSGQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKCGALPDALDHSGYSPLHIA 575 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G+ +LL++GA++ L+ G TP+ +A E++ L Sbjct: 576 AARGKDLIFKMLLRYGASLELRTQQGWTPLHLATYKGHLEIIHQL 620 Score = 56.6 bits (135), Expect = 6e-08 Identities = 30/95 (31%), Positives = 48/95 (50%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + EG+ LH A +G + ++L GA +DA +N TPLH A G+ + Sbjct: 493 ADLSPHEAEGKTPLHVAAYFGHIGLVKLLSGQGAELDAQQRNLRTPLHLAVERGKVRAIQ 552 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LLK GA + G +P+ +A +D + K+L Sbjct: 553 HLLKCGALPDALDHSGYSPLHIAAARGKDLIFKML 587 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/96 (36%), Positives = 49/96 (51%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + D +G LHFA G+ A +LL+ GA V+A + TPLH AA + Sbjct: 426 GADTNLADEDGWAPLHFAAQNGDDHTARLLLDHGALVNAREHEGWTPLHLAAQNNFENVA 485 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ A + +GKTP+ VA +VKLL Sbjct: 486 RLLVSRQADLSPHEAEGKTPLHVAAYFGHIGLVKLL 521 Score = 49.3 bits (116), Expect = 1e-05 Identities = 33/108 (30%), Positives = 50/108 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L + D + G L A + +LL GA + D++ PL Sbjct: 381 GSLEQVRLLLSHDVDVDCQTASGYTPLLIATQDQQPDLCALLLAHGADTNLADEDGWAPL 440 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G LLL HGA V + +G TP+ +A N+ + V +LL Sbjct: 441 HFAAQNGDDHTARLLLDHGALVNAREHEGWTPLHLAAQNNFENVARLL 488 Score = 43.9 bits (102), Expect = 4e-04 Identities = 28/82 (34%), Positives = 36/82 (43%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LHF G L+ +LL VD + TPL A + + LLL HGA L + Sbjct: 374 LHFLVAGGSLEQVRLLLSHDVDVDCQTASGYTPLLIATQDQQPDLCALLLAHGADTNLAD 433 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 DG P+ A N D +LL Sbjct: 434 EDGWAPLHFAAQNGDDHTARLL 455 Score = 43.1 bits (100), Expect = 7e-04 Identities = 30/96 (31%), Positives = 43/96 (44%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + LD GA + + EG LH A A +L+ A + + TPL Sbjct: 447 GDDHTARLLLDHGALVNAREHEGWTPLHLAAQNNFENVARLLVSRQADLSPHEAEGKTPL 506 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H AA +G V LL GA + Q + +TP+ +A Sbjct: 507 HVAAYFGHIGLVKLLSGQGAELDAQQRNLRTPLHLA 542 Score = 42.7 bits (99), Expect = 0.001 Identities = 28/82 (34%), Positives = 41/82 (50%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A GE LL+ GA +A +++ TPLH A G + LL++GA + N Sbjct: 638 LHLAAFQGEEGVMLALLQCGANPNAAEQSGWTPLHLAVHKGTFLGITHLLEYGADIHACN 697 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 G TP +A L ++K+L Sbjct: 698 KVGWTPAHLAALKGNTAILKVL 719 Score = 40.4 bits (93), Expect = 0.005 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 1/94 (1%) Frame = -3 Query: 634 EGLKKAL-DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHY 458 EG+ AL GAN + + G LH A G LLE GA + A +K TP H Sbjct: 647 EGVMLALLQCGANPNAAEQSGWTPLHLAVHKGTFLGITHLLEYGADIHACNKVGWTPAHL 706 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 AA G + +L+K A V ++ TP+++A Sbjct: 707 AALKGNTAILKVLVKAAAQVDVKGGVSCTPLQLA 740 Score = 39.7 bits (91), Expect = 0.008 Identities = 29/90 (32%), Positives = 42/90 (46%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K L GA+ + +G LH A G L+ L ++ +DAL + TPLH AA Sbjct: 585 KMLLRYGASLELRTQQGWTPLHLATYKGHLEIIHQLAKSHVDLDALGSMQWTPLHLAAFQ 644 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 G + + LL+ GA G TP+ +A Sbjct: 645 GEEGVMLALLQCGANPNAAEQSGWTPLHLA 674 Score = 39.3 bits (90), Expect = 0.010 Identities = 30/110 (27%), Positives = 46/110 (41%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ L GA D D G LH A G+ ++LL GA+++ + TPL Sbjct: 546 GKVRAIQHLLKCGALPDALDHSGYSPLHIAAARGKDLIFKMLLRYGASLELRTQQGWTPL 605 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H A G E + L K + TP+ +A ++ V+ L Q Sbjct: 606 HLATYKGHLEIIHQLAKSHVDLDALGSMQWTPLHLAAFQGEEGVMLALLQ 655 Score = 39.3 bits (90), Expect = 0.010 Identities = 21/55 (38%), Positives = 29/55 (52%) Frame = -3 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +N+ TPLH+ G E V LLL H V Q G TP+ +A + Q ++ LL Sbjct: 368 ENRVTPLHFLVAGGSLEQVRLLLSHDVDVDCQTASGYTPLLIATQDQQPDLCALL 422
>Y1425_THEVO (Q978J0) Hypothetical ANK-repeat protein TV1425| Length = 189 Score = 63.2 bits (152), Expect = 7e-10 Identities = 38/109 (34%), Positives = 60/109 (55%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + K ++ +++D+EG AL +A L AE LL G+ V+ D + TP Sbjct: 42 LGMENAIDKLVENFDKLEDKDIEGSTALIWAVKNNRLGIAEKLLSKGSNVNTKDFSGKTP 101 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L ++ +G E LL+HGA V +NL+G+TP+ VA + E+VK L Sbjct: 102 LMWSIIFGYSEMSYFLLEHGANVNDRNLEGETPLIVASKYGRSEIVKKL 150 Score = 57.0 bits (136), Expect = 5e-08 Identities = 34/104 (32%), Positives = 57/104 (54%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 +K L G+N + +D G+ L ++ +G + + LLE GA V+ + TPL A+ Y Sbjct: 82 EKLLSKGSNVNTKDFSGKTPLMWSIIFGYSEMSYFLLEHGANVNDRNLEGETPLIVASKY 141 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 GR E V LL+ GA + ++L G T A++ + EV+K+ + Sbjct: 142 GRSEIVKKLLELGADISARDLTGLTAEASARIFGRQEVIKIFTE 185
>MYPT2_MOUSE (Q8BG95) Protein phosphatase 1 regulatory subunit 12B (Myosin| phosphatase-targeting subunit 2) (Fragment) Length = 484 Score = 62.8 bits (151), Expect = 9e-10 Identities = 40/112 (35%), Positives = 61/112 (54%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S GD + +KK L GA+ + +V+G ALH AC L + L+E A V+ D T Sbjct: 67 SSGDTDEVKKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWT 126 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 PLH AA G + + HGA+V + N +G+ P ++A+ + ++ LLEQ Sbjct: 127 PLHAAASCGYLNIAEYFISHGASVGIVNSEGEVPSDLAEEPAMKDL--LLEQ 176 Score = 47.0 bits (110), Expect = 5e-05 Identities = 33/104 (31%), Positives = 53/104 (50%), Gaps = 1/104 (0%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A G + +L++AG ++ D + TPLH AA +G KE +L + + Sbjct: 217 GATALHVAAAKGYSEVLRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEACSILAEALCDM 276 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKL-LEQDVFL*SKPSDPVLID 269 ++N G+TP +VA + + L +QDV K + LI+ Sbjct: 277 DIRNKLGQTPFDVADEGLVEHLEMLQKKQDVLRSEKETRNKLIE 320
>BARD1_RAT (Q9QZH2) BRCA1-associated RING domain protein 1 (BARD-1)| Length = 768 Score = 62.8 bits (151), Expect = 9e-10 Identities = 33/94 (35%), Positives = 52/94 (55%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD ++ L G + + +D G LH AC +G LK E+LL+ A V+ + ++PL Sbjct: 429 GDISSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKIVELLLQHNALVNTTGYHNDSPL 488 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 H AA G + V +LL HGA+ N+ G+ P++ Sbjct: 489 HDAAKNGHIDIVKVLLSHGASRNAVNIFGERPVD 522 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/99 (31%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G + + G LH A G++ E LL+ G + D TPLH A +G Sbjct: 405 LSSGIPARKRNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHL 464 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V+LLL+H A V +P+ A N ++VK+L Sbjct: 465 KIVELLLQHNALVNTTGYHNDSPLHDAAKNGHIDIVKVL 503
>UACA_BOVIN (Q8HYY4) Uveal autoantigen with coiled-coil domains and ankyrin| repeats protein (Beta-actin-binding protein) (BetaCAP73) Length = 1401 Score = 62.8 bits (151), Expect = 9e-10 Identities = 37/110 (33%), Positives = 54/110 (49%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G+ E L L G + D GR ALH A YG C + LL+ + +D T Sbjct: 64 SKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRT 123 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA + LL HGA+V +++DG+TP+ +A + + +LL Sbjct: 124 ALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMCRPTICQLL 173 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/109 (31%), Positives = 48/109 (44%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKAL-DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD E + L G N + DVEGR A H G L+C +L G + D Sbjct: 32 GDVEKVSSILAKKGVNPGKLDVEGRSAFHVVASKGNLECLNAILIHGVDITTSDTAGRNA 91 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG C+ LL++ +L G+T + A + ++LL Sbjct: 92 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL 140 Score = 43.1 bits (100), Expect = 7e-04 Identities = 36/142 (25%), Positives = 60/142 (42%), Gaps = 33/142 (23%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFA------------CGYGELKCA--------- 527 G A L+K L + D++GR ALH A C +G A Sbjct: 99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPL 158 Query: 526 ------------EILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL 383 ++L++ GA +++ DK T L YG K+ V++L+K+GA V L + Sbjct: 159 VLATQMCRPTICQLLIDRGADINSRDKQNRTALMLGCEYGCKDAVEVLIKNGADVTLLDA 218 Query: 382 DGKTPIEVAKLNSQDEVVKLLE 317 G A++ +++ LL+ Sbjct: 219 LGHDSSYYARIGDNLDILTLLK 240
>ASB13_MOUSE (Q8VBX0) Ankyrin repeat and SOCS box protein 13 (ASB-13)| Length = 278 Score = 62.8 bits (151), Expect = 9e-10 Identities = 40/108 (37%), Positives = 61/108 (56%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G++ L++ +D GA ++ V+ LH A G+ +C ++LL AGA VDA + + +TPL Sbjct: 30 GESLQLQQLIDSGACVNQVTVDSITPLHAASLQGQAQCVQLLLAAGAQVDARNIDGSTPL 89 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G ECV LLL +GA V L +P+ A ++ E V+LL Sbjct: 90 CDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLL 136 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/85 (40%), Positives = 49/85 (57%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 R +H A GE + L+++GA V+ + + TPLH A+ G+ +CV LLL GA V Sbjct: 20 RTPVHEAAQRGESLQLQQLIDSGACVNQVTVDSITPLHAASLQGQAQCVQLLLAAGAQVD 79 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLL 320 +N+DG TP+ A + E VKLL Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLL 104 Score = 52.4 bits (124), Expect = 1e-06 Identities = 36/109 (33%), Positives = 51/109 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L GA K + LH AC G +C +L++ GA ++A D + TPL Sbjct: 96 GSIECVKLLLSYGA-KVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPL 154 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 H A +CV +LL GA V L AK+ + D + L+E Sbjct: 155 HVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIE 203 Score = 34.7 bits (78), Expect = 0.25 Identities = 19/53 (35%), Positives = 27/53 (50%) Frame = -3 Query: 478 KNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + TP+H AA G + L+ GA V +D TP+ A L Q + V+LL Sbjct: 19 ERTPVHEAAQRGESLQLQQLIDSGACVNQVTVDSITPLHAASLQGQAQCVQLL 71
>CTTB2_HUMAN (Q8WZ74) Cortactin-binding protein 2 (CortBP2)| Length = 1663 Score = 62.8 bits (151), Expect = 9e-10 Identities = 36/87 (41%), Positives = 48/87 (55%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G AL+ A G C +LL A A V+A DKN TPL AA G ECV+LL+ + A Sbjct: 743 DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN 802 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G+TP+ +A N E +KLL Sbjct: 803 INHAADGGQTPLYLACKNGNKECIKLL 829 Score = 53.5 bits (127), Expect = 5e-07 Identities = 32/108 (29%), Positives = 49/108 (45%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L A + D G L A G +C E+L+ A ++ TPL Sbjct: 755 GHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPL 814 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A G KEC+ LLL+ G ++ DG TP+ A + +KLL Sbjct: 815 YLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862 Score = 38.5 bits (88), Expect = 0.017 Identities = 23/78 (29%), Positives = 37/78 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ + AN + G+ L+ AC G +C ++LLEAG + TP+ Sbjct: 788 GHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPV 847 Query: 463 HYAAGYGRKECVDLLLKH 410 H A G + + LL+ H Sbjct: 848 HAAVDTGNVDSLKLLMYH 865 Score = 33.9 bits (76), Expect = 0.43 Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 L A G + +LL E G ++ ++ ++ L+ AA G +CV LLL A V Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA 773 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +G TP+ A E V+LL Sbjct: 774 DKNGFTPLCAAAAQGHFECVELL 796
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 62.8 bits (151), Expect = 9e-10 Identities = 39/108 (36%), Positives = 55/108 (50%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L GA+ + G ALH A G + AE+LL+ GA V+ D TPLH A Sbjct: 114 ELITSLLHSGADVQQVGYGGLTALHIAAIAGHPEAAEVLLQHGANVNVQDAVFFTPLHIA 173 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 A YG ++ +LLK GA V + G P+ +A +VKLL ++ Sbjct: 174 AYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEE 221 Score = 44.7 bits (104), Expect = 2e-04 Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 2/112 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + L GAN + +D LH A YG + +LL+ GA V+ + + PL Sbjct: 144 GHPEAAEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPL 203 Query: 463 HYAAGYGRKECVDLLLKHG--AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H A+ G V LL++ G A V Q+ + P+ +V L Q Sbjct: 204 HLASAKGFFNIVKLLVEEGSKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQ 255 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/86 (33%), Positives = 42/86 (48%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A + LL +GA V + T LH AA G E ++LL+HGA V Sbjct: 100 GFPALHLAVYKDSPELITSLLHSGADVQQVGYGGLTALHIAAIAGHPEAAEVLLQHGANV 159 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +Q+ TP+ +A ++V +L Sbjct: 160 NVQDAVFFTPLHIAAYYGHEQVTSVL 185 Score = 33.5 bits (75), Expect = 0.56 Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 2/79 (2%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGE-LKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRK 437 G + +E++ A H AC YG+ + + LL+ A ++ ++ +T LH A +G Sbjct: 293 GTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLHSACYHGHI 352 Query: 436 ECVDLLLKHGAAVMLQNLD 380 V LL +GA + L D Sbjct: 353 RLVQFLLDNGADMNLVACD 371
>EHMT1_HUMAN (Q9H9B1) Histone-lysine N-methyltransferase, H3 lysine-9 specific 5| (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP1) Length = 1267 Score = 62.4 bits (150), Expect = 1e-09 Identities = 37/96 (38%), Positives = 56/96 (58%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K L G++ + D E LH+A G + AEILL A + A++ + ++PLH AA Sbjct: 858 VKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAR 917 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 R +CV L L + V L+N +G+TP++ A LNSQ Sbjct: 918 ENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 953 Score = 48.9 bits (115), Expect = 1e-05 Identities = 29/85 (34%), Positives = 44/85 (51%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 R LH A G + +L++AGA +D +++ TPL AA E V L+K GA V Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLL 320 ++ +G T + +A EVV+ L Sbjct: 803 PKDAEGSTCLHLAAKKGHYEVVQYL 827 Score = 45.8 bits (107), Expect = 1e-04 Identities = 36/100 (36%), Positives = 48/100 (48%), Gaps = 1/100 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 + GAN D + R L A L+ + L++AGA VD D +T LH AA G Sbjct: 762 VQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHY 821 Query: 436 ECVDLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E V LL +G V Q+ G TP+ A ++VKLL Sbjct: 822 EVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861 Score = 42.4 bits (98), Expect = 0.001 Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 1/106 (0%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHY 458 E +K + GA D +D EG LH A G + + LL G V+ D TP+ + Sbjct: 789 EAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIW 848 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A Y + V LLL G+ + +++ + + A + ++ ++L Sbjct: 849 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 894 Score = 40.8 bits (94), Expect = 0.004 Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 7/91 (7%) Frame = -3 Query: 571 RALHFACGYGELKCAEILLEAGAAVDALD-------KNKNTPLHYAAGYGRKECVDLLLK 413 + L+F+ GEL+ ++L VD +D +NK +PLH AA G + +L++ Sbjct: 709 KQLYFSARQGELQKVLLML-----VDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQ 763 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 GA + + D +TP+ A N+ E VK L Sbjct: 764 AGANIDTCSEDQRTPLMEAAENNHLEAVKYL 794
>CTTB2_MICMU (Q2QL82) Cortactin-binding protein 2 (CortBP2)| Length = 1647 Score = 62.4 bits (150), Expect = 1e-09 Identities = 36/87 (41%), Positives = 48/87 (55%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G AL+ A G C +LL A A V+A DKN TPL AA G ECV+LL+ + A Sbjct: 729 DGHSALYSAAKNGHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDAN 788 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G+TP+ +A N E +KLL Sbjct: 789 INHAADGGQTPLYLACKNGNKECIKLL 815 Score = 53.1 bits (126), Expect = 7e-07 Identities = 32/108 (29%), Positives = 50/108 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L+ A + D G L A G +C E+L+ A ++ TPL Sbjct: 741 GHTDCVRLLLNAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDANINHAADGGQTPL 800 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A G KEC+ LLL+ G ++ DG TP+ A + +KLL Sbjct: 801 YLACKNGNKECIKLLLEAGTDRSVKTRDGWTPVHAAVDTGNVDSLKLL 848 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G+ L+ AC G +C ++LLEAG ++ TP+H A G + + LL+ H A Sbjct: 796 GQTPLYLACKNGNKECIKLLLEAGTDRSVKTRDGWTPVHAAVDTGNVDSLKLLMYHRAPA 855 Query: 397 MLQNLDGKTP-IEVAKLNSQDE 335 +L+ + P +V+ L+ +E Sbjct: 856 HGNSLNEEEPESDVSDLDDGEE 877 Score = 33.9 bits (76), Expect = 0.43 Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 L A G + +LL E G ++ ++ ++ L+ AA G +CV LLL A V Sbjct: 700 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVNAA 759 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +G TP+ A E V+LL Sbjct: 760 DKNGFTPLCAAAAQGHFECVELL 782
>BARD1_HUMAN (Q99728) BRCA1-associated RING domain protein 1 (BARD-1)| Length = 777 Score = 62.4 bits (150), Expect = 1e-09 Identities = 36/111 (32%), Positives = 58/111 (52%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD ++ L G++ + +D G LH AC +G LK E+LL+ A V+ ++PL Sbjct: 439 GDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPL 498 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 H AA G + V LLL +GA+ N+ G P++ S ++ L E++ Sbjct: 499 HDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKN 549 Score = 52.0 bits (123), Expect = 2e-06 Identities = 30/86 (34%), Positives = 43/86 (50%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A G++ E LL+ G+ + D TPLH A +G + V+LLL+H A V Sbjct: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +P+ A N ++VKLL Sbjct: 488 NTTGYQNDSPLHDAAKNGHVDIVKLL 513
>CSKI2_XENLA (Q6DD51) Caskin-2| Length = 1205 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/108 (36%), Positives = 60/108 (55%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G++E L L+ A+ D +D G R LH+A G+ + +LL A A+V+A + PL Sbjct: 60 GNSELLLLLLEMQASVDIKDGNGMRPLHYAAWQGQPEPVRLLLRASASVNAASHDGQIPL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA YG E + LL+H + N KTP+++A + +VV+LL Sbjct: 120 HLAAQYGHYEVSETLLQHQSNPCHVNKGKKTPLDLACEFGRVKVVQLL 167 Score = 60.8 bits (146), Expect = 3e-09 Identities = 38/96 (39%), Positives = 52/96 (54%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + +D +G ALH A G + +LLE A+VD D N PLHYAA G+ E V L Sbjct: 41 NVNHQDADGFSALHHAALSGNSELLLLLLEMQASVDIKDGNGMRPLHYAAWQGQPEPVRL 100 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LL+ A+V + DG+ P+ +A EV + L Q Sbjct: 101 LLRASASVNAASHDGQIPLHLAAQYGHYEVSETLLQ 136 Score = 51.2 bits (121), Expect = 3e-06 Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 8/116 (6%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L A+ + +G+ LH A YG + +E LL+ + ++K K TPL Sbjct: 93 GQPEPVRLLLRASASVNAASHDGQIPLHLAAQYGHYEVSETLLQHQSNPCHVNKGKKTPL 152 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGK--------TPIEVAKLNSQDEVVKLL 320 A +GR + V LLL V L K TP+ +A N EV++LL Sbjct: 153 DLACEFGRVKVVQLLLNSHLCVSLLEGTSKDPTDPNFTTPLHLAAKNGHLEVIRLL 208 Score = 48.1 bits (113), Expect = 2e-05 Identities = 34/90 (37%), Positives = 44/90 (48%), Gaps = 8/90 (8%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEA--------GAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 L AC +G +K ++LL + G + D D N TPLH AA G E + LLLK Sbjct: 152 LDLACEFGRVKVVQLLLNSHLCVSLLEGTSKDPTDPNFTTPLHLAAKNGHLEVIRLLLKL 211 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G + G T + A L + EVVKLL Sbjct: 212 GIEINKVTKMG-TALHEAALCGKTEVVKLL 240 Score = 46.6 bits (109), Expect = 6e-05 Identities = 27/83 (32%), Positives = 44/83 (53%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G +KD D LH A G L+ +LL+ G ++ + K T LH AA G+ E V Sbjct: 179 GTSKDPTDPNFTTPLHLAAKNGHLEVIRLLLKLGIEINKVTK-MGTALHEAALCGKTEVV 237 Query: 427 DLLLKHGAAVMLQNLDGKTPIEV 359 LL+++G V ++N +T +++ Sbjct: 238 KLLIENGVDVNIRNTYNQTALDI 260
>ANS4B_MOUSE (Q8K3X6) Ankyrin repeat and SAM domain-containing protein 4B| (Harmonin-interacting ankyrin repeat-containing protein) (Harp) Length = 423 Score = 62.0 bits (149), Expect = 1e-09 Identities = 38/107 (35%), Positives = 52/107 (48%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E LK+A N +ED G A +G L+ EI+ G D D NTPLHYA Sbjct: 15 ELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICSRGGDPDKCDIWGNTPLHYA 72 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G C+ L+ GA + + D K+P++ A Q E V LL++ Sbjct: 73 ASNGHTHCISFLVNFGANIFALDNDLKSPLDAAASREQKECVALLDK 119 Score = 54.7 bits (130), Expect = 2e-07 Identities = 36/101 (35%), Positives = 49/101 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E L+ G + D+ D+ G LH+A G C L+ GA + ALD + +PL Sbjct: 43 GNLEALEIICSRGGDPDKCDIWGNTPLHYAASNGHTHCISFLVNFGANIFALDNDLKSPL 102 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 AA +KECV LL K A +QN P V +L Q Sbjct: 103 DAAASREQKECVALLDK---AATVQNT--MNPKRVTRLKEQ 138
>CTTB2_HORSE (Q2QLA2) Cortactin-binding protein 2 (CortBP2)| Length = 1665 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/87 (41%), Positives = 47/87 (54%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G AL+ A G C +LL A A VDA DKN TPL AA G +CV LL+ + A Sbjct: 744 DGHSALYSAAKNGHTDCVRLLLNAEAQVDAADKNGFTPLCAAAAQGHFKCVQLLIAYDAN 803 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G+TP+ +A N E +KLL Sbjct: 804 INHAADGGQTPLYLACKNGNKECIKLL 830 Score = 56.2 bits (134), Expect = 8e-08 Identities = 33/108 (30%), Positives = 51/108 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L+ A D D G L A G KC ++L+ A ++ TPL Sbjct: 756 GHTDCVRLLLNAEAQVDAADKNGFTPLCAAAAQGHFKCVQLLIAYDANINHAADGGQTPL 815 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A G KEC+ LLL+ G+ ++ DG TP+ A + +KLL Sbjct: 816 YLACKNGNKECIKLLLEAGSDRSIKTRDGWTPVHAAVDTGNVDSLKLL 863 Score = 40.4 bits (93), Expect = 0.005 Identities = 22/70 (31%), Positives = 36/70 (51%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G+ L+ AC G +C ++LLEAG+ ++ TP+H A G + + LL+ H A Sbjct: 811 GQTPLYLACKNGNKECIKLLLEAGSDRSIKTRDGWTPVHAAVDTGNVDSLKLLMYHRAPA 870 Query: 397 MLQNLDGKTP 368 +L + P Sbjct: 871 HGSSLHKEEP 880 Score = 32.0 bits (71), Expect = 1.6 Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 L A G + +LL E G ++ ++ ++ L+ AA G +CV LLL A V Sbjct: 715 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVDAA 774 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +G TP+ A + V+LL Sbjct: 775 DKNGFTPLCAAAAQGHFKCVQLL 797
>UACA_CANFA (Q9GL21) Uveal autoantigen with coiled-coil domains and ankyrin| repeats protein Length = 1415 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/110 (33%), Positives = 53/110 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G+ E L L G + D GR ALH A YG C + LL+ + D T Sbjct: 79 SKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRT 138 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA + LL HGA+V +++DG+TP+ +A + + +LL Sbjct: 139 ALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMCRPAICQLL 188 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/109 (31%), Positives = 48/109 (44%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKAL-DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD E + L G N + DVEGR A H G L+C +L G + D Sbjct: 47 GDVEKVSSILAKKGINPGKLDVEGRSAFHVVASKGNLECLNAILIHGVDITTSDTAGRNA 106 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG C+ LL++ +L G+T + A + ++LL Sbjct: 107 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLL 155 Score = 44.7 bits (104), Expect = 2e-04 Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 33/142 (23%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFA------------CGYGELKCA--------- 527 G A L+K L + D++GR ALH A C +G A Sbjct: 114 GHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPL 173 Query: 526 ------------EILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL 383 ++L++ GA +++ DK T L YG K+ V++LLK+GA V L + Sbjct: 174 VLATQMCRPAICQLLIDRGAEINSRDKQNRTALMLGCEYGCKDAVEVLLKNGADVSLLDA 233 Query: 382 DGKTPIEVAKLNSQDEVVKLLE 317 G A++ +++ LL+ Sbjct: 234 LGHDSSYYARIGDNLDILTLLK 255
>ANS4B_HUMAN (Q8N8V4) Ankyrin repeat and SAM domain-containing protein 4B| (Harmonin-interacting ankyrin repeat-containing protein) (Harp) Length = 460 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/107 (35%), Positives = 53/107 (49%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E LK+A N +ED G A +G L+ EI+ G D D NTPLH+A Sbjct: 15 ELLKEATKRDLNLSDED--GMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFA 72 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G CV L+ GA + + D +TP++ A Q+E V LL++ Sbjct: 73 ASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK 119 Score = 57.4 bits (137), Expect = 4e-08 Identities = 36/101 (35%), Positives = 47/101 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E L+ G + D D+ G LHFA G C L+ GA + ALD + TPL Sbjct: 43 GNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPL 102 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 AA + ECV LL K A + N P +V +L Q Sbjct: 103 DAAASREQNECVALLDKAATAQNIMN-----PKKVTRLKEQ 138
>NOTC4_MOUSE (P31695) Neurogenic locus notch homolog protein 4 precursor (Notch 4)| [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain] Length = 1964 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/96 (39%), Positives = 52/96 (54%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ D G+ ALH+A + A LL+AGA DA D + TPL AA G E Sbjct: 1720 ADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQ 1779 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 LLL+ GAA L++ G P +VA+ S +++ LLE Sbjct: 1780 LLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLE 1815 Score = 47.0 bits (110), Expect = 5e-05 Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 2/111 (1%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDV-EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +G+ E + LD GA V G LH A + A LLEAGA + D+ T Sbjct: 1605 LGNLEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRT 1664 Query: 469 PLHYA-AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH A A R+ C LL +V + DG TP+ +A + +++V+ L Sbjct: 1665 PLHTAVAADAREVCQLLLASRQTSVDARTEDGTTPLMLAARLAVEDLVEEL 1715 Score = 40.8 bits (94), Expect = 0.004 Identities = 31/105 (29%), Positives = 53/105 (50%), Gaps = 2/105 (1%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAG 449 ++ L+ GAN ++ D GR LH A + ++LL + +VDA ++ TPL AA Sbjct: 1646 RRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTSVDARTEDGTTPLMLAAR 1705 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 ++ V+ L+ A V ++ GKT + A +N+ LL+ Sbjct: 1706 LAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQ 1750 Score = 37.4 bits (85), Expect = 0.039 Identities = 29/92 (31%), Positives = 38/92 (41%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D +G L A E L+ A A V A DK T LH+AA LL Sbjct: 1690 DARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLL 1749 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + GA Q+ +TP+ +A EV +LL Sbjct: 1750 QAGADKDAQDSREQTPLFLAAREGAVEVAQLL 1781 Score = 35.8 bits (81), Expect = 0.11 Identities = 18/50 (36%), Positives = 28/50 (56%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA 500 +V +A + L GA+KD +D + L A G ++ A++LLE GAA Sbjct: 1738 AVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAA 1787
>MYPT1_RAT (Q10728) Protein phosphatase 1 regulatory subunit 12A (Myosin| phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (MBSP) (Serine/threonine protein phosphatase PP1 smooth muscle reg Length = 1032 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/108 (32%), Positives = 59/108 (54%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S GD + + K L GA+ + +V+G ALH AC + + L+E GA ++ D Sbjct: 49 SSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWI 108 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 PLH AA G + + L+ GA V N +G TP+++A+ + +E+++ Sbjct: 109 PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156 Score = 43.5 bits (101), Expect = 5e-04 Identities = 27/88 (30%), Positives = 48/88 (54%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A G + ++L++AG V+ D + TPLH AA +G++E +L+ + + Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 258 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 N G+T +VA ++++ LE+ Sbjct: 259 ETVNKVGQTAFDVA----DEDILGYLEE 282
>MYPT1_HUMAN (O14974) Protein phosphatase 1 regulatory subunit 12A (Myosin| phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Length = 1030 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/108 (32%), Positives = 59/108 (54%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S GD + + K L GA+ + +V+G ALH AC + + L+E GA ++ D Sbjct: 49 SSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWI 108 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 PLH AA G + + L+ GA V N +G TP+++A+ + +E+++ Sbjct: 109 PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/99 (29%), Positives = 51/99 (51%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G N G ALH A G + ++L++AG V+ D + TPLH AA +G++E Sbjct: 188 GHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEA 247 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 +L+ + + + N G+T +VA ++++ LE+ Sbjct: 248 CRILVDNLCDMEMVNKVGQTAFDVA----DEDILGYLEE 282
>MYPT2_HUMAN (O60237) Protein phosphatase 1 regulatory subunit 12B (Myosin| phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Length = 982 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/112 (34%), Positives = 61/112 (54%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S GD + ++K L GA+ + +V+G ALH AC L + L+E A V+ D T Sbjct: 67 SSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWT 126 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 PLH AA G + + HGA+V + N +G+ P ++A+ + ++ LLEQ Sbjct: 127 PLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--LLEQ 176 Score = 46.2 bits (108), Expect = 8e-05 Identities = 26/74 (35%), Positives = 41/74 (55%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A G + +L++AG ++ D + TPLH AA +G KE +L + + Sbjct: 217 GATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDM 276 Query: 397 MLQNLDGKTPIEVA 356 ++N G+TP +VA Sbjct: 277 DIRNKLGQTPFDVA 290
>ASB13_HUMAN (Q8WXK3) Ankyrin repeat and SOCS box protein 13 (ASB-13)| Length = 278 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/108 (36%), Positives = 61/108 (56%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G++ L++ ++ GA ++ V+ LH A G+ +C ++LL AGA VDA + + +TPL Sbjct: 30 GESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPL 89 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G ECV LLL +GA V L +P+ A ++ E V+LL Sbjct: 90 CDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLL 136 Score = 58.2 bits (139), Expect = 2e-08 Identities = 35/85 (41%), Positives = 48/85 (56%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 R +H A GE + L+E+GA V+ + + TPLH A+ G+ CV LLL GA V Sbjct: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLL 320 +N+DG TP+ A + E VKLL Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLL 104 Score = 52.4 bits (124), Expect = 1e-06 Identities = 36/109 (33%), Positives = 51/109 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L GA K + LH AC G +C +L++ GA ++A D + TPL Sbjct: 96 GSIECVKLLLSYGA-KVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPL 154 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 H A +CV +LL GA V L AK+ + D + L+E Sbjct: 155 HVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIE 203 Score = 34.7 bits (78), Expect = 0.25 Identities = 19/53 (35%), Positives = 27/53 (50%) Frame = -3 Query: 478 KNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + TP+H AA G + L++ GA V +D TP+ A L Q V+LL Sbjct: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
>MYPT1_MOUSE (Q9DBR7) Protein phosphatase 1 regulatory subunit 12A (Myosin| phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) Length = 1004 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/108 (32%), Positives = 59/108 (54%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S GD + + K L GA+ + +V+G ALH AC + + L+E GA ++ D Sbjct: 49 SSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWI 108 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 PLH AA G + + L+ GA V N +G TP+++A+ + +E+++ Sbjct: 109 PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156 Score = 44.3 bits (103), Expect = 3e-04 Identities = 29/98 (29%), Positives = 51/98 (52%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A G + ++L++AG V+ D + TPLH AA +G++E +L+ + + Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 258 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 N G+T +VA + + +L ++ L S+ D Sbjct: 259 ETVNKVGQTAFDVADEDILGYLEELQKKQTLLHSEKRD 296
>INVS_CHICK (Q8UVC3) Inversin| Length = 1106 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/83 (42%), Positives = 47/83 (56%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 ALH A G + ++LLE A VDALD K+TPL A G KE + L+K GA V L Sbjct: 360 ALHAAALSGHVSTVKLLLERNAQVDALDVMKHTPLFRACEMGHKEVIQTLIKGGARVDLV 419 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + DG +P+ A L +V ++L Sbjct: 420 DQDGHSPLHWAALGGNADVCQIL 442 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/107 (32%), Positives = 55/107 (51%), Gaps = 2/107 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ +K L N ++D+EG LH + KC +LL+ A VD D+NK T Sbjct: 92 GNYRFMKLLLARRGNWMQKDLEGMTPLHLTTRHKSPKCLALLLKHMAPGEVDTQDRNKQT 151 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVV 329 LH++A Y E V LL+KH + + + +++GK P+ A N + Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDIEGKIPLHWAANNKDPSAI 198 Score = 61.2 bits (147), Expect = 3e-09 Identities = 38/109 (34%), Positives = 57/109 (52%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGAN-KDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD L K + G + KD+ED GR L + + CAE LL+AGA V+ D+++ T Sbjct: 25 GDKSTLLKLIAGNSELKDKEDQFGRTPLMYCVLADRVDCAEALLKAGADVNRADRSRRTA 84 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA G + LLL M ++L+G TP+ + + + + LL Sbjct: 85 LHLAAQKGNYRFMKLLLARRGNWMQKDLEGMTPLHLTTRHKSPKCLALL 133 Score = 52.8 bits (125), Expect = 9e-07 Identities = 29/96 (30%), Positives = 51/96 (53%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G +K L+ A D DV L AC G + + L++ GA VD +D++ ++PL Sbjct: 368 GHVSTVKLLLERNAQVDALDVMKHTPLFRACEMGHKEVIQTLIKGGARVDLVDQDGHSPL 427 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H+AA G + +L+++ +Q+ G+TP++ A Sbjct: 428 HWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463 Score = 50.1 bits (118), Expect = 6e-06 Identities = 33/109 (30%), Positives = 53/109 (48%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E ++ + GGA D D +G LH+A G +IL+E + D TP Sbjct: 400 MGHKEVIQTLIKGGARVDLVDQDGHSPLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+ +LL++ A +Q+ +G+T + N + +KLL Sbjct: 460 LQCAAYGGYINCMVVLLENNADPNIQDKEGRTALHWLCNNGYLDAIKLL 508 Score = 46.2 bits (108), Expect = 8e-05 Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A+ + ++ N + +D GR L A G + C +LLE A + DK T L Sbjct: 434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMVVLLENNADPNIQDKEGRTAL 493 Query: 463 HYAAGYGRKECVDLLLKHGAAV--MLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+ G + + LLL A M + + TP++ A L EV++ + Sbjct: 494 HWLCNNGYLDAIKLLLGFDAFPNHMENSEERYTPLDYALLGEHHEVIQFM 543 Score = 46.2 bits (108), Expect = 8e-05 Identities = 30/91 (32%), Positives = 45/91 (49%), Gaps = 2/91 (2%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLE-AGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +D EGR LHFA G + ++L G V + D TPLH+AA G + V LLL+ Sbjct: 217 QDYEGRTPLHFAVADGNVAVVDVLTSYEGCNVTSYDNLFRTPLHWAALLGHAQIVHLLLE 276 Query: 412 HGA-AVMLQNLDGKTPIEVAKLNSQDEVVKL 323 + + G TP+ A ++ E V++ Sbjct: 277 RNKFGTIPSDSQGATPLHYAAQSNFAETVEV 307 Score = 44.3 bits (103), Expect = 3e-04 Identities = 25/73 (34%), Positives = 40/73 (54%), Gaps = 2/73 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 L+ A+ + +D EGR ALH+ C G L ++LL A + ++ ++ TPL YA Sbjct: 476 LENNADPNIQDKEGRTALHWLCNNGYLDAIKLLLGFDAFPNHMENSEERYTPLDYALLGE 535 Query: 442 RKECVDLLLKHGA 404 E + +L+HGA Sbjct: 536 HHEVIQFMLEHGA 548 Score = 42.7 bits (99), Expect = 0.001 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 2/108 (1%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA--LDKNKNTPL 464 AE ++ L + KD+ D+EGR + +A G G +L+ +D DK T L Sbjct: 302 AETVEVFLKHPSVKDDSDLEGRTSFMWAAGKGSDNVIRTMLDLKLDIDINMTDKYAGTAL 361 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G V LLL+ A V ++ TP+ A EV++ L Sbjct: 362 HAAALSGHVSTVKLLLERNAQVDALDVMKHTPLFRACEMGHKEVIQTL 409 Score = 42.7 bits (99), Expect = 0.001 Identities = 30/97 (30%), Positives = 42/97 (43%), Gaps = 1/97 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGA-AVDALDKNKNTPLHYAAGYGRKEC 431 G N D R LH+A G + +LLE D TPLHYAA E Sbjct: 245 GCNVTSYDNLFRTPLHWAALLGHAQIVHLLLERNKFGTIPSDSQGATPLHYAAQSNFAET 304 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V++ LKH + +L+G+T A D V++ + Sbjct: 305 VEVFLKHPSVKDDSDLEGRTSFMWAAGKGSDNVIRTM 341 Score = 30.0 bits (66), Expect = 6.2 Identities = 23/91 (25%), Positives = 37/91 (40%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLL--LK 413 D +G LH+A + E+ L+ + D D T +AAG G + + LK Sbjct: 286 DSQGATPLHYAAQSNFAETVEVFLKHPSVKDDSDLEGRTSFMWAAGKGSDNVIRTMLDLK 345 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + + T + A L+ VKLL Sbjct: 346 LDIDINMTDKYAGTALHAAALSGHVSTVKLL 376
>ANKR2_HUMAN (Q9GZV1) Ankyrin repeat domain-containing protein 2 (Skeletal| muscle ankyrin repeat protein) (hArpp) Length = 333 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/108 (34%), Positives = 58/108 (53%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L+K LD GA D +D A+H+AC G L+ ++L GA + DK +TPL Sbjct: 165 GHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPL 224 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G+ E V+ L G + ++ +G T + A ++ +++KLL Sbjct: 225 HVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLL 272 Score = 56.6 bits (135), Expect = 6e-08 Identities = 38/106 (35%), Positives = 54/106 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++K L G + D D R ALH A G ++ E LL+ GA VD D+ T + Sbjct: 132 GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAM 191 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 H+A G E V LL HGA +++ TP+ VA Q E+V+ Sbjct: 192 HWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVE 237 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/76 (35%), Positives = 39/76 (51%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++K E L G + D D+ + T LH A+ G E ++ LL +GA V Q+ T + Sbjct: 132 GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAM 191 Query: 364 EVAKLNSQDEVVKLLE 317 A EVVKLL+ Sbjct: 192 HWACRGGHLEVVKLLQ 207
>ILK2_HUMAN (P57043) Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2)| Length = 452 Score = 61.2 bits (147), Expect = 3e-09 Identities = 34/107 (31%), Positives = 57/107 (53%), Gaps = 1/107 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANK-DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G+A ++ LD N ++ D G LH+AC G E+L+ GA ++ +++ +TP Sbjct: 11 GNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTP 70 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 LH AA +G ++ V LL++ A + N G P+ A QD+V + Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAE 117 Score = 50.4 bits (119), Expect = 4e-06 Identities = 24/71 (33%), Positives = 43/71 (60%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +G + LL+ A ++A++++ N PLHYA +G+ + + L+ +GA V + N Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130 Query: 385 LDGKTPIEVAK 353 G+ P++ AK Sbjct: 131 KYGEMPVDKAK 141 Score = 37.7 bits (86), Expect = 0.030 Identities = 18/58 (31%), Positives = 32/58 (55%) Frame = -3 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 D + +PLH+A GR V++L+ GA + + N TP+ +A + ++V+ L Q Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQ 88
>ILK1_HUMAN (Q13418) Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59| kDa serine/threonine-protein kinase) (p59ILK) Length = 452 Score = 61.2 bits (147), Expect = 3e-09 Identities = 34/107 (31%), Positives = 57/107 (53%), Gaps = 1/107 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANK-DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G+A ++ LD N ++ D G LH+AC G E+L+ GA ++ +++ +TP Sbjct: 11 GNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTP 70 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 LH AA +G ++ V LL++ A + N G P+ A QD+V + Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAE 117 Score = 50.4 bits (119), Expect = 4e-06 Identities = 24/71 (33%), Positives = 43/71 (60%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +G + LL+ A ++A++++ N PLHYA +G+ + + L+ +GA V + N Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130 Query: 385 LDGKTPIEVAK 353 G+ P++ AK Sbjct: 131 KYGEMPVDKAK 141 Score = 37.7 bits (86), Expect = 0.030 Identities = 18/58 (31%), Positives = 32/58 (55%) Frame = -3 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 D + +PLH+A GR V++L+ GA + + N TP+ +A + ++V+ L Q Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQ 88
>UACA_MOUSE (Q8CGB3) Uveal autoantigen with coiled-coil domains and ankyrin| repeats protein (Nucling) (Nuclear membrane-binding protein) Length = 1411 Score = 61.2 bits (147), Expect = 3e-09 Identities = 36/110 (32%), Positives = 53/110 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G+ E L L G + D GR ALH A YG C + LL+ + +D T Sbjct: 79 SKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRT 138 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH A + LL HGA+V +++DG+TP+ +A + + +LL Sbjct: 139 ALHDAVMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLL 188 Score = 53.5 bits (127), Expect = 5e-07 Identities = 34/109 (31%), Positives = 48/109 (44%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKAL-DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD E + L G + + DVEGR A H G L+C +L G V D Sbjct: 47 GDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNA 106 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA YG C+ LL++ +L G+T + A + ++LL Sbjct: 107 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAVMADCPSSIQLL 155 Score = 34.7 bits (78), Expect = 0.25 Identities = 18/54 (33%), Positives = 28/54 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 +D GA+ + D + R AL C YG E+L++ GA + LD + +YA Sbjct: 189 IDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYA 242
>ILK_CAVPO (P57044) Integrin-linked protein kinase (EC 2.7.11.1)| (Beta-integrin-linked kinase) Length = 451 Score = 61.2 bits (147), Expect = 3e-09 Identities = 34/107 (31%), Positives = 57/107 (53%), Gaps = 1/107 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANK-DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G+A ++ LD N ++ D G LH+AC G E+L+ GA ++ +++ +TP Sbjct: 11 GNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTP 70 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 LH AA +G ++ V LL++ A + N G P+ A QD+V + Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAE 117 Score = 49.7 bits (117), Expect = 8e-06 Identities = 24/71 (33%), Positives = 43/71 (60%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +G + LL+ A ++A++++ N PLHYA +G+ + + L+ +GA V + N Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130 Query: 385 LDGKTPIEVAK 353 G+ P++ AK Sbjct: 131 KYGEMPMDKAK 141 Score = 37.7 bits (86), Expect = 0.030 Identities = 18/58 (31%), Positives = 32/58 (55%) Frame = -3 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 D + +PLH+A GR V++L+ GA + + N TP+ +A + ++V+ L Q Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQ 88
>CTTB2_CALJA (Q2QLF8) Cortactin-binding protein 2 (CortBP2)| Length = 1662 Score = 61.2 bits (147), Expect = 3e-09 Identities = 35/87 (40%), Positives = 48/87 (55%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G AL+ A G C +LL A A V+A DKN TPL AA G ECV+LL+ + A Sbjct: 742 DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDAN 801 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G+TP+ +A N E ++LL Sbjct: 802 INHAADGGQTPLYLACKNGNKECIRLL 828 Score = 52.8 bits (125), Expect = 9e-07 Identities = 32/108 (29%), Positives = 49/108 (45%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L A + D G L A G +C E+L+ A ++ TPL Sbjct: 754 GHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIAYDANINHAADGGQTPL 813 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A G KEC+ LLL+ G ++ DG TP+ A + +KLL Sbjct: 814 YLACKNGNKECIRLLLEAGTDRSVKTTDGWTPVHAAVDTGNVDSLKLL 861 Score = 37.4 bits (85), Expect = 0.039 Identities = 19/56 (33%), Positives = 28/56 (50%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 G+ L+ AC G +C +LLEAG + TP+H A G + + LL+ H Sbjct: 809 GQTPLYLACKNGNKECIRLLLEAGTDRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH 864 Score = 33.9 bits (76), Expect = 0.43 Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 L A G + +LL E G ++ ++ ++ L+ AA G +CV LLL A V Sbjct: 713 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA 772 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +G TP+ A E V+LL Sbjct: 773 DKNGFTPLCAAAAQGHFECVELL 795
>MIB1_BRARE (Q804S5) Ubiquitin ligase protein mib (EC 6.3.2.-) (Mind bomb| protein) Length = 1030 Score = 61.2 bits (147), Expect = 3e-09 Identities = 36/108 (33%), Positives = 55/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + LK L + + ED +G RA+H A E E+L GA ++A +K + TPL Sbjct: 475 GHVDVLKLLLKHSVDLEAEDKDGDRAVHHASFGDEGSVIEVLHRGGADLNARNKRRQTPL 534 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G + V LL G LQ+ +G TP+ A +D+++ +L Sbjct: 535 HIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVL 582 Score = 48.9 bits (115), Expect = 1e-05 Identities = 37/130 (28%), Positives = 59/130 (45%), Gaps = 1/130 (0%) Frame = -3 Query: 649 SVGDAEGLKKALD-GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN 473 S GD + + L GGA+ + + + LH A G L+ + LL+ G D + Sbjct: 505 SFGDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SK 293 TPLH A R + + +LL+ GA V + N +G + A L +++L SK Sbjct: 565 TPLHDAISKKRDDMLSVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL------SK 618 Query: 292 PSDPVLIDPK 263 P ++D K Sbjct: 619 LPRPWIVDEK 628 Score = 45.1 bits (105), Expect = 2e-04 Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 1/81 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLL 419 DE+ +G ALH A ++ AE+L+ G A +D + N+ T LH A + V LL Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLL 685 Query: 418 LKHGAAVMLQNLDGKTPIEVA 356 ++ A + +Q+ DG TP+ A Sbjct: 686 VRAEAKLDVQDKDGDTPLHEA 706 Score = 38.9 bits (89), Expect = 0.013 Identities = 20/52 (38%), Positives = 29/52 (55%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 G AN D ++V + ALH A + +L+ A A +D DK+ +TPLH A Sbjct: 655 GNANLDVQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA 706 Score = 37.0 bits (84), Expect = 0.051 Identities = 22/86 (25%), Positives = 44/86 (51%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G A+ A G + ++LL+ ++A DK+ + +H+A+ +++L + GA + Sbjct: 464 GHTAMQAASQNGHVDVLKLLLKHSVDLEAEDKDGDRAVHHASFGDEGSVIEVLHRGGADL 523 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +N +TP+ +A +VVK L Sbjct: 524 NARNKRRQTPLHIAVNKGHLQVVKTL 549
>INVS_CANFA (Q6JAN1) Inversin (Inversion of embryo turning protein)| (Nephrocystin-2) Length = 1081 Score = 61.2 bits (147), Expect = 3e-09 Identities = 36/98 (36%), Positives = 54/98 (55%), Gaps = 2/98 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ +K L AN ++D+E LH A + KC +LL+ A VD DKNK T Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLATRHKSPKCLALLLKFMAPGEVDTQDKNKQT 151 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH++A Y E V LL+KH + + + +++GK P+ A Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA 189 Score = 58.5 bits (140), Expect = 2e-08 Identities = 39/109 (35%), Positives = 57/109 (52%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD L + + G A KD+ED GR L + L CA+ LL+AGA V+ D ++ T Sbjct: 25 GDKGALHRLIIGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTA 84 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA G + LLL A M ++L+ TP+ +A + + + LL Sbjct: 85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLATRHKSPKCLALL 133 Score = 56.2 bits (134), Expect = 8e-08 Identities = 34/89 (38%), Positives = 47/89 (52%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A G + ++LLE A VDA D K+TPL A G K+ + L+K G Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V L + DG + + A L +V ++L Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQIL 442 Score = 50.4 bits (119), Expect = 4e-06 Identities = 26/73 (35%), Positives = 43/73 (58%), Gaps = 2/73 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 ++ A+ + +D EGR ALH++C G L ++LL+ A + ++ N+ TPL YA Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535 Query: 442 RKECVDLLLKHGA 404 R E + +L+HGA Sbjct: 536 RHEVIQFMLEHGA 548 Score = 49.7 bits (117), Expect = 8e-06 Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A+ + ++ N + +D GR L A G + C +L+E A + DK T L Sbjct: 434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493 Query: 463 HYAAGYGRKECVDLLLKHGA--AVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H++ G + + LLL A M N + TP++ A L + EV++ + Sbjct: 494 HWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFM 543 Score = 49.7 bits (117), Expect = 8e-06 Identities = 28/96 (29%), Positives = 49/96 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G +K L+ A D DV L AC G + L++ GA VD +D++ ++ L Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H+AA G + +L+++ +Q+ G+TP++ A Sbjct: 428 HWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463 Score = 49.3 bits (116), Expect = 1e-05 Identities = 31/109 (28%), Positives = 54/109 (49%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + ++ + GGA D D +G LH+A G +IL+E + D TP Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+ +L+++ A +Q+ +G+T + + N + +KLL Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508 Score = 45.8 bits (107), Expect = 1e-04 Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLLL- 416 +D EGR LHFA G + ++L + + + D TPLH+AA G + V LLL Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 ++ + + + G TP+ A ++ E VK+ Sbjct: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKV 307 Score = 43.1 bits (100), Expect = 7e-04 Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 2/108 (1%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA--LDKNKNTPL 464 AE +K L + KD+ D+EGR + +A G G +L + +D DK T L Sbjct: 302 AETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTAL 361 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G V LLL++ A V ++ TP+ A +V++ L Sbjct: 362 HAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409 Score = 42.7 bits (99), Expect = 0.001 Identities = 33/101 (32%), Positives = 49/101 (48%), Gaps = 2/101 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ ++ D R ALH A G + ++LL A D + TPLH A + Sbjct: 68 LKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLATRHKSP 127 Query: 436 ECVDLLLKHGA--AVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +C+ LLLK A V Q+ + +T + + + E VKLL Sbjct: 128 KCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLL 168 Score = 40.8 bits (94), Expect = 0.004 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 1/86 (1%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 R LH+A G + +LLE + D TPLHYAA E V + LKH + Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +L+G+T A D+V++ + Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTM 341 Score = 35.8 bits (81), Expect = 0.11 Identities = 32/113 (28%), Positives = 50/113 (44%), Gaps = 8/113 (7%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGE---LKCAEILLEAGAAVDAL---DKNKN 473 E +K + +N DVEG+ LH+A + + + +L+A L D Sbjct: 163 EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222 Query: 472 TPLHYAAGYGRKECVDLLLKHGAA--VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPLH+A G VD+L + + NL +TP+ A L ++V LL Sbjct: 223 TPLHFAVADGNVTVVDVLTSYESCNITSYDNL-FRTPLHWAALLGHAQIVHLL 274 Score = 32.3 bits (72), Expect = 1.3 Identities = 22/98 (22%), Positives = 44/98 (44%), Gaps = 6/98 (6%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY------GRKE 434 D +D + ALH++ Y + ++L++ + + D PLH+AA + Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 C+ + + Q+ +G+TP+ A + VV +L Sbjct: 203 CILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240 Score = 32.0 bits (71), Expect = 1.6 Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD--LLLK 413 D +G LH+A + ++ L+ + D D T +AAG G + + L LK Sbjct: 286 DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + + G T + A L+ VKLL Sbjct: 346 SDIDINMADKYGGTALHAAALSGHVSTVKLL 376
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 61.2 bits (147), Expect = 3e-09 Identities = 36/110 (32%), Positives = 57/110 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G +K GA D + R LH A G+++ + LL++GA DALD++ PL Sbjct: 505 GHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPL 564 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H AA G+ +LL++GA++ L G TP+ +A E++ LL + Sbjct: 565 HTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614 Score = 60.1 bits (144), Expect = 6e-09 Identities = 37/96 (38%), Positives = 50/96 (52%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + D +G LHFA G+ A +LL+ GA VDA ++ TPLH AA + Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ A L +GKTP+ VA +VKLL Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513 Score = 53.9 bits (128), Expect = 4e-07 Identities = 29/95 (30%), Positives = 46/95 (48%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + + EG+ LH A +G + ++L GA +DA +N TPLH A G+ + Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LLK GA + G P+ A + + K+L Sbjct: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKML 579 Score = 51.2 bits (121), Expect = 3e-06 Identities = 38/123 (30%), Positives = 57/123 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L + D + G L A + +LL GA + +D++ PL Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 H+AA G LLL HGA V Q +G TP+ +A N+ + V +LL S+ +D Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV------SRQAD 486 Query: 283 PVL 275 P L Sbjct: 487 PNL 489 Score = 47.4 bits (111), Expect = 4e-05 Identities = 33/110 (30%), Positives = 49/110 (44%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ L GA D D G LH A G+ ++LL GA+++ TPL Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H AA G E + LL + A + TP+ +A + ++ VV L Q Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647 Score = 46.6 bits (109), Expect = 6e-05 Identities = 36/104 (34%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K L GA+ + +G LH A G L+ +L E+ A + AL TPLH AA + Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARH 636 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQD-EVVKLLE 317 G + V LL+ GA G TP+ +A S V+ LLE Sbjct: 637 GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLE 680 Score = 46.6 bits (109), Expect = 6e-05 Identities = 31/96 (32%), Positives = 44/96 (45%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + LD GA D ++ EG LH A A +L+ A + + TPL Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPL 498 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H AA +G V LL GA + Q + +TP+ +A Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/82 (35%), Positives = 41/82 (50%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +GE LL+ GA +A +++ TPLH A V LL+H A V +N Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 G TP +A L ++K+L Sbjct: 690 KVGWTPAHLAALKGNTAILKVL 711 Score = 40.8 bits (94), Expect = 0.004 Identities = 27/82 (32%), Positives = 36/82 (43%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LHF G ++ +LL VD + TPL AA + + LLL HGA + Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 DG P+ A N D +LL Sbjct: 426 EDGWAPLHFAAQNGDDGTARLL 447 Score = 40.4 bits (93), Expect = 0.005 Identities = 22/55 (40%), Positives = 29/55 (52%) Frame = -3 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +NK TPLH+ G E V LLL H V Q G TP+ +A + Q ++ LL Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALL 414 Score = 38.5 bits (88), Expect = 0.017 Identities = 30/109 (27%), Positives = 50/109 (45%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ + L GA+ + + G LH A LLE A V A +K TP Sbjct: 637 GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 H AA G + +L++ GA + +Q+ TP+++A + + ++ LE Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
>CDN2C_HUMAN (P42773) Cyclin-dependent kinase 6 inhibitor (p18-INK6)| (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c) Length = 168 Score = 61.2 bits (147), Expect = 3e-09 Identities = 41/111 (36%), Positives = 60/111 (54%), Gaps = 1/111 (0%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G+ E ++ L GAN D +D G +H A G L + LLE A V+ D N P Sbjct: 47 LGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLP 106 Query: 466 LHYAAGYGRKECVDLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 LH AA G V+ L+KH A+ V +N G T ++A+L ++EVV L++ Sbjct: 107 LHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQ 157
>Y1861_PYRAE (Q8ZWC4) Hypothetical ANK-repeat protein PAE1861| Length = 256 Score = 60.8 bits (146), Expect = 3e-09 Identities = 34/97 (35%), Positives = 53/97 (54%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GDA +K L+ G + + D G+ LH A + +C E+LL+ G V+ D TPL Sbjct: 134 GDAGLVKLLLEYGVDPNARDAHGKTPLHMASEHNCAQCVELLLKRGPDVNVKDGAGRTPL 193 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 HYA +C+ LLL++GA + + G+TP+ A+ Sbjct: 194 HYADDV---DCIKLLLRYGADLNAVDNMGRTPLHYAE 227 Score = 49.3 bits (116), Expect = 1e-05 Identities = 28/74 (37%), Positives = 41/74 (55%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH G L ++LLE G +A D + TPLH A+ + +CV+LLLK G V Sbjct: 125 GESLLHLVAGDAGL--VKLLLEYGVDPNARDAHGKTPLHMASEHNCAQCVELLLKRGPDV 182 Query: 397 MLQNLDGKTPIEVA 356 +++ G+TP+ A Sbjct: 183 NVKDGAGRTPLHYA 196 Score = 49.3 bits (116), Expect = 1e-05 Identities = 30/75 (40%), Positives = 41/75 (54%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 GE + LL G + D D TPL+YAA G VDLL+K GA ++ +GKTPI Sbjct: 13 GEAELLTRLLNEGCSPDVQDDYGRTPLYYAAERGDVGTVDLLIKAGADPNARDREGKTPI 72 Query: 364 EVAKLNSQDEVVKLL 320 +A + + V+ LL Sbjct: 73 IIATQSRKFGVIPLL 87 Score = 43.5 bits (101), Expect = 5e-04 Identities = 21/60 (35%), Positives = 37/60 (61%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+AE L + L+ G + D +D GR L++A G++ ++L++AGA +A D+ TP+ Sbjct: 13 GEAELLTRLLNEGCSPDVQDDYGRTPLYYAAERGDVGTVDLLIKAGADPNARDREGKTPI 72
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 60.8 bits (146), Expect = 3e-09 Identities = 38/105 (36%), Positives = 52/105 (49%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L GA+ + G ALH A G + E+LL+ GA V+ D TPLH A Sbjct: 114 ELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIA 173 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A YG ++ +LLK GA V + G P+ +A +VKLL Sbjct: 174 AYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLL 218 Score = 48.1 bits (113), Expect = 2e-05 Identities = 31/86 (36%), Positives = 43/86 (50%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH A L+ LL +GA V T LH AA G E V++LL+HGA V Sbjct: 100 GFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANV 159 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +Q+ TP+ +A ++V +L Sbjct: 160 NVQDAVFFTPLHIAAYYGHEQVTSVL 185 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/111 (28%), Positives = 50/111 (45%), Gaps = 1/111 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L GAN + +D LH A YG + +LL+ GA V+ + + PL Sbjct: 144 GHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPL 203 Query: 463 HYAAGYGRKECVDLLLK-HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H A+ G V LL++ + A V Q+ + P+ +V L Q Sbjct: 204 HLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQ 254 Score = 33.5 bits (75), Expect = 0.56 Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 2/79 (2%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGE-LKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRK 437 G + +E++ A H AC YG+ + + LL+ A ++ ++ +T LH A +G Sbjct: 292 GTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLHSACYHGHI 351 Query: 436 ECVDLLLKHGAAVMLQNLD 380 V LL +GA + L D Sbjct: 352 RLVQFLLDNGADMNLVACD 370
>TRPA1_RAT (Q6RI86) Transient receptor potential cation channel subfamily A| member 1 (Ankyrin-like with transmembrane domains protein 1) Length = 1125 Score = 60.8 bits (146), Expect = 3e-09 Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 3/94 (3%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +ED +G LH+AC G LL +V + K+K +PLH+AA YGR LL+ Sbjct: 409 DEDNDGCTPLHYACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQ 468 Query: 412 HGAAVMLQN---LDGKTPIEVAKLNSQDEVVKLL 320 + L N L G TP+ +A N D+VV+LL Sbjct: 469 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 502 Score = 52.8 bits (125), Expect = 9e-07 Identities = 32/112 (28%), Positives = 58/112 (51%), Gaps = 4/112 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE----AGAAVDALDKNK 476 GD + +K LD GA+ D + ALHFA G ++++ + V+A+D N+ Sbjct: 251 GDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIVNAVDGNQ 310 Query: 475 NTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LH A+ + + D L+ GA + + +G++P+ +A ++ +V LL Sbjct: 311 ETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVNLL 362 Score = 51.2 bits (121), Expect = 3e-06 Identities = 33/120 (27%), Positives = 59/120 (49%), Gaps = 13/120 (10%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRAL-----------HFACGYGELKCAEILLEAGA--AVD 494 E K ++G + E ++ RR L H A G+++ ++++ + A++ Sbjct: 34 ESFKVDIEGDMCRLEAFIKNRRKLSKYEDENLCLLHHAAAEGQVELMQLIINGSSCEALN 93 Query: 493 ALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 +D NTPLH+AA + E V LL GA L+N + P+ +A +EV+K+L + Sbjct: 94 VMDDYGNTPLHWAAEKNQVESVKFLLSQGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTE 153 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDAL---DKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 LHFA YG + + LL+ + L D + TPLH AA G + V LLLK G A+ Sbjct: 451 LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKG-ALF 509 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLL 320 L + +G T + A + + +K++ Sbjct: 510 LSDHNGWTALHHASMGGYTQTMKVI 534 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 8/101 (7%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + E G AL C + +ILLE GA + +K + P+H AA G K C++L Sbjct: 158 NINLEGENGNTALMSTCAKDNSEALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMEL 217 Query: 421 LLKHG--------AAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 +L +G A + N +P+ +A + +++K+ Sbjct: 218 ILAYGEKTGYSREAHINFVNHKKASPLHLAVQSGDLDMIKM 258 Score = 37.7 bits (86), Expect = 0.030 Identities = 20/65 (30%), Positives = 37/65 (56%), Gaps = 2/65 (3%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH--GAAVML 392 LH A G+L ++ L++GA +D ++ K LH+AA G + V L++ G++ ++ Sbjct: 244 LHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIV 303 Query: 391 QNLDG 377 +DG Sbjct: 304 NAVDG 308 Score = 36.2 bits (82), Expect = 0.087 Identities = 31/108 (28%), Positives = 46/108 (42%), Gaps = 5/108 (4%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACG--YGELKCAEILLEAGAAVDAL---DKNKNTPLHYAA 452 L GA D +D GR LH YG L+ + + D + TPLHYA Sbjct: 363 LSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHYAC 422 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDV 308 G V+ LL+ +V ++ D K+P+ A + + L QD+ Sbjct: 423 RQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDI 470 Score = 36.2 bits (82), Expect = 0.087 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 1/90 (1%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G LH+A +++ + LL GA + ++N PLH A E + +L +H Sbjct: 96 DDYGNTPLHWAAEKNQVESVKFLLSQGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHK 155 Query: 406 AA-VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A + L+ +G T + E +++L Sbjct: 156 ATNINLEGENGNTALMSTCAKDNSEALQIL 185 Score = 30.8 bits (68), Expect = 3.6 Identities = 19/64 (29%), Positives = 31/64 (48%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A + A+ L+ GA +++ D +PL A V+LLL GA V +++ Sbjct: 314 LHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVNLLLSKGAKVDIKD 373 Query: 385 LDGK 374 G+ Sbjct: 374 HLGR 377
>ILK_MOUSE (O55222) Integrin-linked protein kinase (EC 2.7.11.1)| Length = 452 Score = 60.1 bits (144), Expect = 6e-09 Identities = 34/107 (31%), Positives = 56/107 (52%), Gaps = 1/107 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANK-DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G+A ++ LD N ++ D G LH+AC G E+L+ GA ++ +++ +TP Sbjct: 11 GNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTP 70 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 LH AA +G ++ V LL++ A N G P+ A QD+V + Sbjct: 71 LHLAASHGHRDIVQKLLQYKADTNAVNEHGNVPLHYACFWGQDQVAE 117 Score = 49.3 bits (116), Expect = 1e-05 Identities = 24/71 (33%), Positives = 42/71 (59%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +G + LL+ A +A++++ N PLHYA +G+ + + L+ +GA V + N Sbjct: 71 LHLAASHGHRDIVQKLLQYKADTNAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130 Query: 385 LDGKTPIEVAK 353 G+ P++ AK Sbjct: 131 KYGEMPVDKAK 141 Score = 37.7 bits (86), Expect = 0.030 Identities = 18/58 (31%), Positives = 32/58 (55%) Frame = -3 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 D + +PLH+A GR V++L+ GA + + N TP+ +A + ++V+ L Q Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQ 88
>FANK1_RAT (Q66H07) Fibronectin type 3 and ankyrin repeat domains 1 protein| Length = 344 Score = 60.1 bits (144), Expect = 6e-09 Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TP 467 G + +K GA+ D D+ G ALH+A G + +++ G VD +D TP Sbjct: 188 GHLDVVKYLRKHGASWDARDLGGCTALHWAADGGHCPVIDWMIKDGCEVDVVDTGSGWTP 247 Query: 466 L-HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L +A G ++ LL++ GA V +++ DGKTP+ VA LN+ +++V+LL Sbjct: 248 LMRVSAVTGSQKVASLLIEAGADVNVRDKDGKTPLMVAVLNNHEQLVQLL 297 Score = 53.1 bits (126), Expect = 7e-07 Identities = 30/77 (38%), Positives = 45/77 (58%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G K A +L+EAGA V+ DK+ TPL A ++ V LLL GA ++N GK + Sbjct: 256 GSQKVASLLIEAGADVNVRDKDGKTPLMVAVLNNHEQLVQLLLDKGADATVKNEFGKGVL 315 Query: 364 EVAKLNSQDEVVKLLEQ 314 E+A++ + V+ LLE+ Sbjct: 316 EMARVFDRQNVLSLLEE 332
>MIB_DROME (Q9VUX2) Ubiquitin ligase protein mind-bomb (EC 6.3.2.-) (Mind bomb| homolog) (D-mib) Length = 1226 Score = 60.1 bits (144), Expect = 6e-09 Identities = 38/108 (35%), Positives = 54/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L + + ED +G RA+H A E EIL +AGA ++A +K + T L Sbjct: 579 GHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSL 638 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G V LL G LQ+ +G TP+ A DE++ LL Sbjct: 639 HIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHDEMLSLL 686 Score = 47.0 bits (110), Expect = 5e-05 Identities = 29/96 (30%), Positives = 42/96 (43%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + + + +LH A G L + LL G D +TPLH A E + Sbjct: 624 GADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHDEML 683 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LLL GA + L N +G + A L +K+L Sbjct: 684 SLLLDFGADITLNNNNGFNALHHAALKGNPSAMKIL 719 Score = 40.4 bits (93), Expect = 0.005 Identities = 37/112 (33%), Positives = 53/112 (47%), Gaps = 4/112 (3%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN---TPL 464 E L LD GA+ + G ALH A G +ILL +++ K+ T L Sbjct: 681 EMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTAL 740 Query: 463 HYAAGYGRKECVDLLLKHGAAVM-LQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 H AA E +LL+ G A M QN++ +T + +A ++VKLL QD Sbjct: 741 HLAALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQD 792 Score = 38.1 bits (87), Expect = 0.023 Identities = 19/52 (36%), Positives = 32/52 (61%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 G AN D ++V + ALH A ++ ++L++ GA ++ DK+ +TPLH A Sbjct: 759 GKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEA 810 Score = 38.1 bits (87), Expect = 0.023 Identities = 24/86 (27%), Positives = 41/86 (47%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G AL A G ++ ++LL V+ DK+ + +H+AA +++L K GA + Sbjct: 568 GHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADL 627 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +N +T + +A VVK L Sbjct: 628 NARNKRRQTSLHIAVNKGHLNVVKTL 653
>PP16A_MOUSE (Q923M0) Protein phosphatase 1 regulatory subunit 16A (Myosin| phosphatase targeting subunit 3) Length = 524 Score = 60.1 bits (144), Expect = 6e-09 Identities = 38/104 (36%), Positives = 57/104 (54%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 L+ L GAN + G LH A G + A +LLE GA++ A D + PLH AA Sbjct: 215 LQNRLQAGANLSDPLDHGATLLHIAAANGFSEVATLLLEQGASLSAKDHDGWEPLHAAAY 274 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 +G+ V+LL+ HGA + ++L +TP++V ++ KLLE Sbjct: 275 WGQVHLVELLVAHGADLNGKSLVDETPLDVC--GDEEVRAKLLE 316 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/96 (35%), Positives = 52/96 (54%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 D E +++ L G + + + +G ALH C + A+ LL+AGA V+A D TPLH Sbjct: 83 DLEEVRQFLTSGVSPNLANEDGLTALHQCCIDDFQEMAQQLLDAGADVNARDSECWTPLH 142 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 AA G V+LL+ GA ++ N DG P ++ + Sbjct: 143 AAATCGHLHLVELLISRGADLLAVNSDGNMPYDLCE 178 Score = 33.9 bits (76), Expect = 0.43 Identities = 20/70 (28%), Positives = 33/70 (47%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E ++ LD GA+ + D E LH A G L E+L+ GA + A++ + N P Sbjct: 118 EMAQQLLDAGADVNARDSECWTPLHAAATCGHLHLVELLISRGADLLAVNSDGNMPYDLC 177 Query: 454 AGYGRKECVD 425 +C++ Sbjct: 178 EDAQTLDCLE 187
>CTTB2_CALMO (Q2QLB3) Cortactin-binding protein 2 (CortBP2)| Length = 1663 Score = 60.1 bits (144), Expect = 6e-09 Identities = 35/87 (40%), Positives = 47/87 (54%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G AL+ A G C +LL A A V+A D N TPL AA G ECV+LL+ + A Sbjct: 743 DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADTNGFTPLCAAAAQGHFECVELLIAYDAN 802 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G+TP+ +A N E +KLL Sbjct: 803 INHAAGGGQTPLYLACKNGNKECIKLL 829 Score = 53.5 bits (127), Expect = 5e-07 Identities = 32/108 (29%), Positives = 49/108 (45%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + ++ L A + D G L A G +C E+L+ A ++ TPL Sbjct: 755 GHTDCVRLLLSAEAQVNAADTNGFTPLCAAAAQGHFECVELLIAYDANINHAAGGGQTPL 814 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A G KEC+ LLL+ G ++ DG TP+ A + +KLL Sbjct: 815 YLACKNGNKECIKLLLEAGTDRCVKTTDGWTPVHAAVDTGNVDSLKLL 862 Score = 34.3 bits (77), Expect = 0.33 Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 L A G + +LL E G ++ ++ ++ L+ AA G +CV LLL A V Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA 773 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +G TP+ A E V+LL Sbjct: 774 DTNGFTPLCAAAAQGHFECVELL 796
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 60.1 bits (144), Expect = 6e-09 Identities = 34/110 (30%), Positives = 52/110 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + LK + D +D G ALH A YG ++L G+ D DK + TPL Sbjct: 423 GHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPL 482 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H AA +G L + G V ++N +G+TP+ A ++V+ L + Sbjct: 483 HCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAE 532 Score = 56.2 bits (134), Expect = 8e-08 Identities = 38/105 (36%), Positives = 47/105 (44%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K L G+ D +D G LH AC G L EA +D +K TPLH A Sbjct: 558 EVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISNKYGRTPLHLA 617 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G + V L GA V DGKT ++AK + V LL Sbjct: 618 ANNGILDVVRYLCLMGANVEALTSDGKTAEDLAKAEQHEHVAGLL 662 Score = 55.8 bits (133), Expect = 1e-07 Identities = 34/108 (31%), Positives = 53/108 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G A+ ++ G+N D +D E LH A +G A+ L E G V+ ++ TPL Sbjct: 456 GHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPL 515 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A+ G + V+ L +HGA + + DG + +A Q EV+K L Sbjct: 516 LTASARGYHDIVECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTL 563 Score = 53.9 bits (128), Expect = 4e-07 Identities = 32/108 (29%), Positives = 53/108 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ + L+ + G+ D +D G A+++A +G + + L E +D DK+ T L Sbjct: 390 GNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVKDKSGETAL 449 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA YG + V LL G+ Q+ + +TP+ A + V K L Sbjct: 450 HVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKAL 497 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/96 (33%), Positives = 50/96 (52%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + D +G ALH A +++ + LL G+ VD D++ NTPLH A G V Sbjct: 534 GADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIV 593 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L + + + N G+TP+ +A N +VV+ L Sbjct: 594 VALCEASCNLDISNKYGRTPLHLAANNGILDVVRYL 629 Score = 48.5 bits (114), Expect = 2e-05 Identities = 37/104 (35%), Positives = 50/104 (48%), Gaps = 1/104 (0%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K + G N + ++ EG L A G E L E GA ++A DK+ + LH A Sbjct: 495 KALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNASDKDGHIALHLAVRR 554 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQDEVVKLLE 317 + E + LL HG+ V Q+ G TP+ VA K S VV L E Sbjct: 555 CQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCE 598
>OSBL1_RAT (Q8K4M9) Oxysterol-binding protein-related protein 1 (OSBP-related| protein 1) (ORP-1) Length = 950 Score = 59.7 bits (143), Expect = 7e-09 Identities = 43/119 (36%), Positives = 64/119 (53%), Gaps = 10/119 (8%) Frame = -3 Query: 643 GDAEGLKKALDGGANKD---EEDVEGRRA-------LHFACGYGELKCAEILLEAGAAVD 494 G+AE ++K L+ A + + D +GR LH AC +G + + LL+AGA V+ Sbjct: 16 GNAEEVRKLLEAMARAEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVQDLLKAGAKVN 75 Query: 493 ALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 L+ +TPLH AA GRKE V LLL++ A + N G+T E E+ ++LE Sbjct: 76 MLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTVVNGSGQTAKEA---THDKEIRQMLE 131 Score = 38.9 bits (89), Expect = 0.013 Identities = 20/48 (41%), Positives = 30/48 (62%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 V+ D+ NTPLH AA K+CV LL+ GA L+N + + P+++A Sbjct: 169 VNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLA 216
>ACBD6_XENLA (Q4V869) Acyl-CoA-binding domain-containing protein 6| Length = 286 Score = 59.7 bits (143), Expect = 7e-09 Identities = 33/84 (39%), Positives = 44/84 (52%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + + D EGR LH+AC G + ++L A ++ D TPLHYA+ + Sbjct: 172 GSVDVNVADDEGRSLLHWACDRGHTQLVSVILFHNAHINMQDSEGQTPLHYASACEFPDI 231 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEV 359 VDLLL HGA L + DG P EV Sbjct: 232 VDLLLDHGADPSLVDNDGFQPHEV 255 Score = 38.1 bits (87), Expect = 0.023 Identities = 22/77 (28%), Positives = 38/77 (49%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V+ D + LH+A G + V ++L H A + +Q+ +G+TP+ A ++V LL Sbjct: 176 VNVADDEGRSLLHWACDRGHTQLVSVILFHNAHINMQDSEGQTPLHYASACEFPDIVDLL 235 Query: 319 EQDVFL*SKPSDPVLID 269 +DP L+D Sbjct: 236 L------DHGADPSLVD 246
>ACBD6_RAT (Q5RJK8) Acyl-CoA-binding domain-containing protein 6| Length = 282 Score = 59.7 bits (143), Expect = 7e-09 Identities = 33/88 (37%), Positives = 48/88 (54%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D EGR LH+AC G + ++LL+ A ++ D T LHYAA + V+LLL+ G Sbjct: 189 DEEGRALLHWACDRGHKELVKVLLQCEAGINCQDNEGQTALHYAAACEFSDIVELLLQSG 248 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 A L++ DG P EV + V++L Sbjct: 249 ADPTLRDQDGCLPEEVTGCKAVSLVLQL 276 Score = 37.4 bits (85), Expect = 0.039 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 5/103 (4%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V+ D+ LH+A G KE V +LL+ A + Q+ +G+T + A ++V+LL Sbjct: 185 VNMTDEEGRALLHWACDRGHKELVKVLLQCEAGINCQDNEGQTALHYAAACEFSDIVELL 244 Query: 319 EQDVFL*SKPSDPVLID-----PKTLPCFWSLSGVMSWHGVGR 206 Q +DP L D P+ + ++S V+ H G+ Sbjct: 245 LQ------SGADPTLRDQDGCLPEEVTGCKAVSLVLQLHRAGK 281
>INVS_HUMAN (Q9Y283) Inversin (Inversion of embryo turning homolog)| (Nephrocystin-2) Length = 1065 Score = 59.7 bits (143), Expect = 7e-09 Identities = 35/98 (35%), Positives = 53/98 (54%), Gaps = 2/98 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ +K L AN ++D+E LH + KC +LL+ A VD DKNK T Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH++A Y E V LL+KH + + + +++GK P+ A Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA 189 Score = 57.4 bits (137), Expect = 4e-08 Identities = 38/109 (34%), Positives = 57/109 (52%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD L++ + G A KD+ED GR L + L CA+ LL+AGA V+ D ++ T Sbjct: 25 GDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTA 84 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA G + LLL A M ++L+ TP+ + + + + LL Sbjct: 85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133 Score = 56.2 bits (134), Expect = 8e-08 Identities = 34/89 (38%), Positives = 47/89 (52%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A G + ++LLE A VDA D K+TPL A G K+ + L+K G Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V L + DG + + A L +V ++L Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQIL 442 Score = 50.4 bits (119), Expect = 4e-06 Identities = 26/73 (35%), Positives = 43/73 (58%), Gaps = 2/73 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 ++ A+ + +D EGR ALH++C G L ++LL+ A + ++ N+ TPL YA Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535 Query: 442 RKECVDLLLKHGA 404 R E + +L+HGA Sbjct: 536 RHEVIQFMLEHGA 548 Score = 49.7 bits (117), Expect = 8e-06 Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A+ + ++ N + +D GR L A G + C +L+E A + DK T L Sbjct: 434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493 Query: 463 HYAAGYGRKECVDLLLKHGA--AVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H++ G + + LLL A M N + TP++ A L + EV++ + Sbjct: 494 HWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFM 543 Score = 49.7 bits (117), Expect = 8e-06 Identities = 28/96 (29%), Positives = 49/96 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G +K L+ A D DV L AC G + L++ GA VD +D++ ++ L Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H+AA G + +L+++ +Q+ G+TP++ A Sbjct: 428 HWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463 Score = 49.3 bits (116), Expect = 1e-05 Identities = 31/109 (28%), Positives = 54/109 (49%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + ++ + GGA D D +G LH+A G +IL+E + D TP Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+ +L+++ A +Q+ +G+T + + N + +KLL Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508 Score = 45.8 bits (107), Expect = 1e-04 Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLLL- 416 +D EGR LHFA G + ++L + + + D TPLH+AA G + V LLL Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 ++ + + + G TP+ A ++ E VK+ Sbjct: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKV 307 Score = 43.1 bits (100), Expect = 7e-04 Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 2/108 (1%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA--LDKNKNTPL 464 AE +K L + KD+ D+EGR + +A G G +L + +D DK T L Sbjct: 302 AETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTAL 361 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G V LLL++ A V ++ TP+ A +V++ L Sbjct: 362 HAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409 Score = 40.8 bits (94), Expect = 0.004 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 1/86 (1%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 R LH+A G + +LLE + D TPLHYAA E V + LKH + Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +L+G+T A D+V++ + Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTM 341 Score = 35.8 bits (81), Expect = 0.11 Identities = 32/113 (28%), Positives = 50/113 (44%), Gaps = 8/113 (7%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGE---LKCAEILLEAGAAVDAL---DKNKN 473 E +K + +N DVEG+ LH+A + + + +L+A L D Sbjct: 163 EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222 Query: 472 TPLHYAAGYGRKECVDLLLKHGAA--VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPLH+A G VD+L + + NL +TP+ A L ++V LL Sbjct: 223 TPLHFAVADGNVTVVDVLTSYESCNITSYDNL-FRTPLHWAALLGHAQIVHLL 274 Score = 32.3 bits (72), Expect = 1.3 Identities = 22/98 (22%), Positives = 44/98 (44%), Gaps = 6/98 (6%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY------GRKE 434 D +D + ALH++ Y + ++L++ + + D PLH+AA + Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 C+ + + Q+ +G+TP+ A + VV +L Sbjct: 203 CILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240 Score = 32.0 bits (71), Expect = 1.6 Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD--LLLK 413 D +G LH+A + ++ L+ + D D T +AAG G + + L LK Sbjct: 286 DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + + G T + A L+ VKLL Sbjct: 346 SDIDINMADKYGGTALHAAALSGHVSTVKLL 376
>LIN12_CAEEL (P14585) Protein lin-12 precursor (Abnormal cell lineage protein 12)| Length = 1429 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 1/108 (0%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILL-EAGAAVDALDKNKNTPLHY 458 +G K DG A KD E +GR ALH+A + + L+ E G+ D D++ TP+ Sbjct: 1188 KGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIML 1247 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 AA GR E V L++ GA+V + T ++A+ N+ +V + ++ Sbjct: 1248 AAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDR 1295 Score = 35.0 bits (79), Expect = 0.19 Identities = 21/61 (34%), Positives = 33/61 (54%) Frame = -3 Query: 529 AEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKL 350 A+ + AGA V+A+D ++NTPL A R+ V L+K GA + N ++ + A Sbjct: 1077 AKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAA 1136 Query: 349 N 347 N Sbjct: 1137 N 1137
>MIB2_RAT (Q68LP1) Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb| homolog 2) (RBSC-skeletrophin/dystrophin-like polypeptide) Length = 971 Score = 59.3 bits (142), Expect = 1e-08 Identities = 36/87 (41%), Positives = 47/87 (54%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +GR AL A G+++ +LL+A A+VD LD+ NT LHY A + E LLL G Sbjct: 478 QGRTALQVAAYLGQVELVRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCG 537 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V QN T + VA EVVK+L Sbjct: 538 VDAQNGTRSTALHVAVQRGFLEVVKIL 564 Score = 56.2 bits (134), Expect = 8e-08 Identities = 33/97 (34%), Positives = 48/97 (49%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E ++ L A+ D D EG ALH+ + + +LL AG VDA + ++T Sbjct: 489 LGQVELVRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTA 548 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH A G E V +L +HG V L + TP+ A Sbjct: 549 LHVAVQRGFLEVVKILCEHGCDVNLPDAHADTPLHSA 585 Score = 41.6 bits (96), Expect = 0.002 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 3/98 (3%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L G D ++ ALH A G L+ +IL E G V+ D + +TPLH A Sbjct: 526 EATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLEVVKILCEHGCDVNLPDAHADTPLHSA 585 Query: 454 --AGYGRKECVDLLLK-HGAAVMLQNLDGKTPIEVAKL 350 AG G V++L + G V N G T + A L Sbjct: 586 ISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASL 623
>TRPA1_MOUSE (Q8BLA8) Transient receptor potential cation channel subfamily A| member 1 (Ankyrin-like with transmembrane domains protein 1) Length = 1125 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/94 (37%), Positives = 50/94 (53%), Gaps = 3/94 (3%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +ED +G LH+AC G LL ++ + K+K +PLH+AA YGR LL+ Sbjct: 409 DEDNDGCTPLHYACRQGVPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 468 Query: 412 HGAAVMLQN---LDGKTPIEVAKLNSQDEVVKLL 320 + L N L G TP+ +A N D+VV+LL Sbjct: 469 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 502 Score = 51.2 bits (121), Expect = 3e-06 Identities = 31/112 (27%), Positives = 58/112 (51%), Gaps = 4/112 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE----AGAAVDALDKNK 476 GD + +K LD GA+ D + ALHFA G ++++ + V+A+D N+ Sbjct: 251 GDLDMIKMCLDNGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIVNAVDGNQ 310 Query: 475 NTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LH A+ + + + L+ GA + + +G++P+ +A ++ +V LL Sbjct: 311 ETLLHRASLFDHHDLAEYLISVGADINSTDSEGRSPLILATASASWNIVNLL 362 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDAL---DKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 LHFA YG + + LL+ + L D + TPLH AA G + V LLLK G A+ Sbjct: 451 LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKG-ALF 509 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLL 320 L + +G T + A + + +K++ Sbjct: 510 LSDHNGWTALHHASMGGYTQTMKVI 534 Score = 41.2 bits (95), Expect = 0.003 Identities = 23/65 (35%), Positives = 35/65 (53%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + E G AL C + +ILLE GA + +K + P+H AA G K+C++L Sbjct: 158 NINLEGENGNTALMSTCAKDNSEALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKKCMEL 217 Query: 421 LLKHG 407 +L +G Sbjct: 218 ILAYG 222 Score = 36.6 bits (83), Expect = 0.066 Identities = 20/65 (30%), Positives = 36/65 (55%), Gaps = 2/65 (3%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH--GAAVML 392 LH A G+L ++ L+ GA +D ++ K LH+AA G + V L++ G++ ++ Sbjct: 244 LHLAVQSGDLDMIKMCLDNGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIV 303 Query: 391 QNLDG 377 +DG Sbjct: 304 NAVDG 308 Score = 35.0 bits (79), Expect = 0.19 Identities = 19/52 (36%), Positives = 30/52 (57%), Gaps = 2/52 (3%) Frame = -3 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLD--GKTPIEVAKLNSQDEVVKLL 320 PLH+AA G+ E ++L++ + +L +D G TP+ A +Q E VK L Sbjct: 67 PLHHAAAEGQVELMELIINGSSCEVLNIMDGYGNTPLHCAAEKNQVESVKFL 118 Score = 32.0 bits (71), Expect = 1.6 Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 5/105 (4%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACG--YGELKCAEILLEAGAAVDAL---DKNKNTPLHYAAGYG 443 GA D +D GR LH YG ++ + + D + TPLHYA G Sbjct: 366 GAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFMQMQHIKELVMDEDNDGCTPLHYACRQG 425 Query: 442 RKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDV 308 V+ LL ++ ++ D K+P+ A + + L QD+ Sbjct: 426 VPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDI 470 Score = 30.8 bits (68), Expect = 3.6 Identities = 20/64 (31%), Positives = 31/64 (48%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A + AE L+ GA +++ D +PL A V+LLL GA V +++ Sbjct: 314 LHRASLFDHHDLAEYLISVGADINSTDSEGRSPLILATASASWNIVNLLLCKGAKVDIKD 373 Query: 385 LDGK 374 G+ Sbjct: 374 HLGR 377
>TRPA1_HUMAN (O75762) Transient receptor potential cation channel subfamily A| member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120) Length = 1119 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/94 (37%), Positives = 50/94 (53%), Gaps = 3/94 (3%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +ED +G LH+AC G LL ++ + K+K +PLH+AA YGR LL+ Sbjct: 408 DEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467 Query: 412 HGAAVMLQN---LDGKTPIEVAKLNSQDEVVKLL 320 + L N L G TP+ +A N D+VV+LL Sbjct: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 501 Score = 48.5 bits (114), Expect = 2e-05 Identities = 31/112 (27%), Positives = 55/112 (49%), Gaps = 4/112 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA----VDALDKNK 476 GD E +K LD GA D + A+HFA G + ++++ + + V+ D Sbjct: 250 GDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCH 309 Query: 475 NTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LH A+ + E D L+ GA + + +G++P+ +A ++ +V LL Sbjct: 310 ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 1/87 (1%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGA-AVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 D G ALH A G + +++L+ D LD++ NT LH+AA G + V LLL H Sbjct: 511 DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSH 570 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVV 329 A ++L N + + +A N + EVV Sbjct: 571 NADIVL-NKQQASFLHLALHNKRKEVV 596 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDAL---DKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 LHFA YG + + LL+ + L D + TPLH AA G + V LLLK G A+ Sbjct: 450 LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKG-ALF 508 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLL 320 L + +G T + A + + +K++ Sbjct: 509 LSDHNGWTALHHASMGGYTQTMKVI 533 Score = 42.4 bits (98), Expect = 0.001 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 8/97 (8%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 E G A+ AC + +ILL GA +K P+H AA G KEC++++L+ Sbjct: 161 EGENGNTAVIIACTTNNSEALQILLNKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRF 220 Query: 409 GAA--------VMLQNLDGKTPIEVAKLNSQDEVVKL 323 G + N TP+ +A N E++K+ Sbjct: 221 GEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKM 257 Score = 42.0 bits (97), Expect = 0.002 Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 4/86 (4%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK--HGAAVML 392 LH A G+L+ ++ L+ GA +D ++K + T +H+AA G E V L++ G+ ++ Sbjct: 243 LHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIV 302 Query: 391 QNLDG--KTPIEVAKLNSQDEVVKLL 320 DG +T + A L E+ L Sbjct: 303 NTTDGCHETMLHRASLFDHHELADYL 328 Score = 38.5 bits (88), Expect = 0.017 Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 E D G LH A +++ + LL GA + + N PLH A E + +LL+ Sbjct: 93 EMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLE 152 Query: 412 HGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H V L+ +G T + +A + E +++L Sbjct: 153 HRTIDVNLEGENGNTAVIIACTTNNSEALQIL 184 Score = 33.5 bits (75), Expect = 0.56 Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 5/108 (4%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACG--YGELKCAEILLEAGAAVDAL---DKNKNTPLHYAA 452 L GA D +D GR LH YG ++ + + D + TPLHYA Sbjct: 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 421 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDV 308 G V+ LL ++ ++ D K+P+ A + + L QD+ Sbjct: 422 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDI 469
>ACBD6_XENTR (Q66JD7) Acyl-CoA-binding domain-containing protein 6| Length = 286 Score = 59.3 bits (142), Expect = 1e-08 Identities = 34/84 (40%), Positives = 44/84 (52%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + + D EGR LH+AC G + +LL A ++ D TPLHYA+ + Sbjct: 172 GAIDVNVADDEGRCLLHWACDRGHTQLVSVLLFHNAHINMQDSEGQTPLHYASACEFPDI 231 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEV 359 VDLLL HGA L + DG P EV Sbjct: 232 VDLLLDHGADPSLVDNDGFQPHEV 255 Score = 38.5 bits (88), Expect = 0.017 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 1/84 (1%) Frame = -3 Query: 517 LEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 L GA V+ D LH+A G + V +LL H A + +Q+ +G+TP+ A Sbjct: 169 LSTGAIDVNVADDEGRCLLHWACDRGHTQLVSVLLFHNAHINMQDSEGQTPLHYASACEF 228 Query: 340 DEVVKLLEQDVFL*SKPSDPVLID 269 ++V LL +DP L+D Sbjct: 229 PDIVDLLL------DHGADPSLVD 246
>ANKR6_HUMAN (Q9Y2G4) Ankyrin repeat domain-containing protein 6| Length = 692 Score = 59.3 bits (142), Expect = 1e-08 Identities = 34/99 (34%), Positives = 52/99 (52%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G + D +D + ALH A G + L+ G A+D DK+ NT LH A+ +G Sbjct: 62 LKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFS 121 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LL+K GA V+ +N G T + +A NS + ++L Sbjct: 122 QSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL 160 Score = 57.0 bits (136), Expect = 5e-08 Identities = 36/109 (33%), Positives = 57/109 (52%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 VG+ E + + G D +D +G ALH A +G + A++L++AGA V A +K NT Sbjct: 85 VGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTA 144 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH A + +LL G+ L+N G T + VA + +++LL Sbjct: 145 LHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/106 (31%), Positives = 53/106 (50%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHY 458 ++ + L G+ D ++ G LH A Y L +LL A +V ++ +T LH Sbjct: 154 SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA K+ +LL+ GA + N G+TP+E A+ ++ EV LL Sbjct: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259 Score = 55.5 bits (132), Expect = 1e-07 Identities = 35/108 (32%), Positives = 50/108 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + + ++ GA + GR LH A G L +ILL+AG +D D T L Sbjct: 21 GQTENVVQLINKGA-RVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTAL 79 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G E + L+ G A+ Q+ DG T + A + + KLL Sbjct: 80 HRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLL 127 Score = 52.8 bits (125), Expect = 9e-07 Identities = 34/108 (31%), Positives = 51/108 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ K + GAN ++ G ALH AC + +LL AG+ D + +T L Sbjct: 119 GFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCL 178 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA Y + LLL +V +N G T + VA + +V K+L Sbjct: 179 HVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL 226 Score = 37.0 bits (84), Expect = 0.051 Identities = 23/60 (38%), Positives = 29/60 (48%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 E++ G ALH A K A+ILLEAGA ++ TPL A + E LL K Sbjct: 202 EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261
>ANKR2_MOUSE (Q9WV06) Ankyrin repeat domain-containing protein 2 (Skeletal| muscle ankyrin repeat protein) (mArpp) Length = 328 Score = 59.3 bits (142), Expect = 1e-08 Identities = 43/135 (31%), Positives = 58/135 (42%), Gaps = 33/135 (24%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L+K L+ GA D +D A+H+AC G L+ +L GA + DK +TPL Sbjct: 161 GHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVRLLQSRGADTNVRDKLLSTPL 220 Query: 463 HYAAGYGRKECVD---------------------------------LLLKHGAAVMLQNL 383 H A G E V+ LLL HGA +M +NL Sbjct: 221 HVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLHGADMMAKNL 280 Query: 382 DGKTPIEVAKLNSQD 338 GKTP ++ +L D Sbjct: 281 AGKTPTDLVQLWQAD 295 Score = 51.6 bits (122), Expect = 2e-06 Identities = 37/106 (34%), Positives = 51/106 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + + K L G + D D R ALH A G ++ E LLE GA VD D+ T + Sbjct: 128 GKMKVIDKYLADGGSADTCDEFRRTALHRASLEGHMEILEKLLENGATVDFQDRLDCTAM 187 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 H+A G E V LL GA +++ TP+ VA E+V+ Sbjct: 188 HWACRGGHLEVVRLLQSRGADTNVRDKLLSTPLHVAVRTGHVEIVE 233
>INVSB_XENLA (Q71S21) Inversin-B| Length = 1002 Score = 59.3 bits (142), Expect = 1e-08 Identities = 35/89 (39%), Positives = 48/89 (53%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A G++ ILLE A DA+D K+TPL A G +E + L+K G Sbjct: 350 DKYGGTALHAASLSGQITTVRILLENRAQADAVDVMKHTPLFRACEMGHREVIATLIKGG 409 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V L + DG++P+ A L V ++L Sbjct: 410 AKVHLVDKDGRSPLHWAALGGNANVCQIL 438 Score = 57.4 bits (137), Expect = 4e-08 Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A + ++ N D +D EGR L A G + C E+L+E A + DKN T L Sbjct: 430 GNANVCQILIENNINPDAQDYEGRTPLQCAAYGGYIGCMEVLMENKADPNIQDKNGRTAL 489 Query: 463 HYAAGYGRKECVDLLLKHGA-AVMLQNLDGK-TPIEVAKLNSQDEVVKLL 320 H++ G + V LLL + A ++N + + TP++ A L EV++ + Sbjct: 490 HWSCNNGYLDAVKLLLGYNAFPNQMENTEERYTPLDYALLGGHQEVIQFM 539 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/109 (32%), Positives = 55/109 (50%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E + + GGA D +GR LH+A G +IL+E DA D TP Sbjct: 396 MGHREVIATLIKGGAKVHLVDKDGRSPLHWAALGGNANVCQILIENNINPDAQDYEGRTP 455 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+++L+++ A +Q+ +G+T + + N + VKLL Sbjct: 456 LQCAAYGGYIGCMEVLMENKADPNIQDKNGRTALHWSCNNGYLDAVKLL 504 Score = 52.8 bits (125), Expect = 9e-07 Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 2/98 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ LK L A+ D+ ALH + + + +C +LL+ VDA D+ K T Sbjct: 88 GNHRLLKLLLSRKADCTHRDLCDITALHLSTRHQDTQCLVLLLKYTPPGQVDAQDQRKQT 147 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH++A Y R + V LL++HG+ + + + +GK P+ A Sbjct: 148 ALHWSAYYNRPQHVRLLVRHGSNIGIPDTEGKIPLHWA 185 Score = 49.3 bits (116), Expect = 1e-05 Identities = 28/96 (29%), Positives = 47/96 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ L+ A D DV L AC G + L++ GA V +DK+ +PL Sbjct: 364 GQITTVRILLENRAQADAVDVMKHTPLFRACEMGHREVIATLIKGGAKVHLVDKDGRSPL 423 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H+AA G +L+++ Q+ +G+TP++ A Sbjct: 424 HWAALGGNANVCQILIENNINPDAQDYEGRTPLQCA 459 Score = 46.2 bits (108), Expect = 8e-05 Identities = 24/73 (32%), Positives = 41/73 (56%), Gaps = 2/73 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 ++ A+ + +D GR ALH++C G L ++LL A + ++ + TPL YA G Sbjct: 472 MENKADPNIQDKNGRTALHWSCNNGYLDAVKLLLGYNAFPNQMENTEERYTPLDYALLGG 531 Query: 442 RKECVDLLLKHGA 404 +E + +L+HGA Sbjct: 532 HQEVIQFMLEHGA 544 Score = 43.9 bits (102), Expect = 4e-04 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 6/98 (6%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKE------ 434 D +D + ALH++ Y + +L+ G+ + D PLH+AAG+ E Sbjct: 139 DAQDQRKQTALHWSAYYNRPQHVRLLVRHGSNIGIPDTEGKIPLHWAAGHKDPEAALTVR 198 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 C+ + + Q+ +G+TP+ +A + EVV+LL Sbjct: 199 CLFEAAPTESLLNWQDYEGRTPLHLAVGDGNQEVVRLL 236 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/92 (31%), Positives = 45/92 (48%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D+ED GR L ++ CAE LL+ GA V+ D++ T LH AA G + LLL Sbjct: 38 DQEDQLGRTPLMYSVLGDRRSCAEALLKHGAKVNRPDRSGRTALHLAAQTGNHRLLKLLL 97 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A ++L T + ++ + + + LL Sbjct: 98 SRKADCTHRDLCDITALHLSTRHQDTQCLVLL 129 Score = 42.7 bits (99), Expect = 0.001 Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 1/97 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA-LDKNKNTPLHYAAGYGRKEC 431 G N D R LH+A G A +LLE + + D TPLHYAA + Sbjct: 241 GCNVAPYDNLFRTPLHWAALLGHTPIAHLLLERNNSPNIPSDSQGATPLHYAAQGNCPDT 300 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V +LL H + +L+G+T + A DEVV+ + Sbjct: 301 VRVLLSHPSVRDEADLEGRTALMWAAGKGSDEVVRTM 337 Score = 42.0 bits (97), Expect = 0.002 Identities = 21/68 (30%), Positives = 35/68 (51%) Frame = -3 Query: 523 ILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 ++ + +D D+ TPL Y+ R+ C + LLKHGA V + G+T + +A Sbjct: 29 LIASSPQVIDQEDQLGRTPLMYSVLGDRRSCAEALLKHGAKVNRPDRSGRTALHLAAQTG 88 Query: 343 QDEVVKLL 320 ++KLL Sbjct: 89 NHRLLKLL 96 Score = 40.0 bits (92), Expect = 0.006 Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 7/103 (6%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCA---EILLEAGAAVDAL---DKNKNTPLHYAAGY 446 G+N D EG+ LH+A G+ + + A L EA L D TPLH A G Sbjct: 168 GSNIGIPDTEGKIPLHWAAGHKDPEAALTVRCLFEAAPTESLLNWQDYEGRTPLHLAVGD 227 Query: 445 GRKECVDLLLKH-GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G +E V LL + G V + +TP+ A L + LL Sbjct: 228 GNQEVVRLLTSYRGCNVAPYDNLFRTPLHWAALLGHTPIAHLL 270 Score = 35.4 bits (80), Expect = 0.15 Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D +G LH+A +LL + D D T L +AAG G E V +L+ Sbjct: 282 DSQGATPLHYAAQGNCPDTVRVLLSHPSVRDEADLEGRTALMWAAGKGSDEVVRTMLELN 341 Query: 406 AAVMLQNLD--GKTPIEVAKLNSQDEVVKLL 320 + + D G T + A L+ Q V++L Sbjct: 342 PKLEVNRTDKYGGTALHAASLSGQITTVRIL 372
>CDN2C_MOUSE (Q60772) Cyclin-dependent kinase 6 inhibitor (p18-INK6)| (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c) Length = 168 Score = 58.9 bits (141), Expect = 1e-08 Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 1/111 (0%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G+ E ++ L GAN + +D G +H A G L + LLE A V+ D N P Sbjct: 47 LGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLP 106 Query: 466 LHYAAGYGRKECVDLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 LH AA G V+ L+KH A V +N G T ++A+ ++EV+ L+E Sbjct: 107 LHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFYGRNEVISLME 157
>MIB1_XENLA (Q6GNY1) Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb| homolog 1) Length = 1011 Score = 58.9 bits (141), Expect = 1e-08 Identities = 35/108 (32%), Positives = 54/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + LK L + + ED +G RA+H A E E+L GA ++A +K + TPL Sbjct: 475 GHVDILKLLLKHSVDVEAEDKDGDRAVHHAAFGDEGTVIEVLQRGGADLNARNKRRQTPL 534 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G + V LL LQ+ +G TP+ A +D+++ +L Sbjct: 535 HIAVNKGHLQVVKKLLDFSCHPSLQDSEGDTPLHDAISKKRDDILAVL 582 Score = 47.0 bits (110), Expect = 5e-05 Identities = 37/111 (33%), Positives = 51/111 (45%), Gaps = 3/111 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + +KK LD + +D EG LH A +LLEAGA V + N L Sbjct: 541 GHLQVVKKLLDFSCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL 600 Query: 463 HYAAGYGRKECVDLLLK---HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G + +LL V + DG T + +A LN+ EV +LL Sbjct: 601 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELL 651 Score = 46.2 bits (108), Expect = 8e-05 Identities = 28/81 (34%), Positives = 45/81 (55%), Gaps = 1/81 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLL 419 DE+ +G ALH A ++ AE+L+ G+A +D + N+ T LH A + V LL Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGSANLDIQNVNQQTALHLAVERQHTQIVRLL 685 Query: 418 LKHGAAVMLQNLDGKTPIEVA 356 ++ A + +Q+ DG TP+ A Sbjct: 686 VRAEAKLDIQDKDGDTPLHEA 706 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/116 (27%), Positives = 52/116 (44%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 GGA+ + + + LH A G L+ + LL+ D +TPLH A R + Sbjct: 519 GGADLNARNKRRQTPLHIAVNKGHLQVVKKLLDFSCHPSLQDSEGDTPLHDAISKKRDDI 578 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLIDPK 263 + +LL+ GA V + N +G + A L +++L SK P ++D K Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL------SKLPRPWIVDEK 628 Score = 39.3 bits (90), Expect = 0.010 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 4/110 (3%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGY----GELKCAEILLEAGAAVDALDKNKNT 470 A G +D + + DV G+ A H A G + ++LL+ V+A DK+ + Sbjct: 440 ANGDVAKVDDLLKRQDVDVNGQCAGHTAMQAASQNGHVDILKLLLKHSVDVEAEDKDGDR 499 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +H+AA +++L + GA + +N +TP+ +A +VVK L Sbjct: 500 AVHHAAFGDEGTVIEVLQRGGADLNARNKRRQTPLHIAVNKGHLQVVKKL 549 Score = 38.1 bits (87), Expect = 0.023 Identities = 20/52 (38%), Positives = 29/52 (55%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 G AN D ++V + ALH A + +L+ A A +D DK+ +TPLH A Sbjct: 655 GSANLDIQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDIQDKDGDTPLHEA 706
>FANK1_MOUSE (Q9DAM9) Fibronectin type 3 and ankyrin repeat domains 1 protein| (Germ cell-specific gene 1 protein) (GSG1) Length = 344 Score = 58.9 bits (141), Expect = 1e-08 Identities = 35/98 (35%), Positives = 58/98 (59%), Gaps = 2/98 (2%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TPL-HYAAGYGRKE 434 GA+ + D+ G ALH+A G + +++ G VD +D TPL +A G ++ Sbjct: 200 GASWEARDLGGCTALHWAADGGHCSVIDWMIKDGCEVDVVDTGSGWTPLMRVSAVTGSQK 259 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL++ GA V +++ DGKTP+ VA LN+ +++V+LL Sbjct: 260 VASLLIEAGADVNIKDKDGKTPLMVAVLNNHEQLVQLL 297 Score = 52.8 bits (125), Expect = 9e-07 Identities = 30/77 (38%), Positives = 45/77 (58%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G K A +L+EAGA V+ DK+ TPL A ++ V LLL GA ++N GK + Sbjct: 256 GSQKVASLLIEAGADVNIKDKDGKTPLMVAVLNNHEQLVQLLLDKGADATVKNEFGKGVL 315 Query: 364 EVAKLNSQDEVVKLLEQ 314 E+A++ + V+ LLE+ Sbjct: 316 EMARVFDRQNVLSLLEE 332
>OSBL1_HUMAN (Q9BXW6) Oxysterol-binding protein-related protein 1 (OSBP-related| protein 1) (ORP-1) Length = 950 Score = 58.9 bits (141), Expect = 1e-08 Identities = 37/91 (40%), Positives = 52/91 (57%), Gaps = 3/91 (3%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH AC +G + + LL+AGA V+ L+ +TPLH AA GRKE V LLL++ A Sbjct: 48 GWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADT 107 Query: 397 MLQNLDGKTPIEVA---KLNSQDEVVKLLEQ 314 + N G+T EV ++ S E V+ +Q Sbjct: 108 TIVNGSGQTAKEVTHAEEIRSMLEAVERTQQ 138 Score = 37.4 bits (85), Expect = 0.039 Identities = 19/49 (38%), Positives = 30/49 (61%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 V+ D+ NTPLH AA K+C LL+ GA L+N + + P+++A+ Sbjct: 169 VNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQ 217
>MIB1_MOUSE (Q80SY4) Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb| homolog 1) (DAPK-interacting protein 1) (DIP-1) Length = 1006 Score = 58.9 bits (141), Expect = 1e-08 Identities = 35/108 (32%), Positives = 54/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + LK L + + ED +G RA+H A E E+L A ++A +K + TPL Sbjct: 475 GHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPL 534 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G + V LL G LQ+ +G TP+ A +D+++ +L Sbjct: 535 HIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/81 (35%), Positives = 45/81 (55%), Gaps = 1/81 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLL 419 DE+ +G ALH A ++ AE+L+ G A +D + N+ T LH A + V LL Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685 Query: 418 LKHGAAVMLQNLDGKTPIEVA 356 ++ GA + +Q+ DG TP+ A Sbjct: 686 VRAGAKLDIQDKDGDTPLHEA 706 Score = 47.0 bits (110), Expect = 5e-05 Identities = 37/111 (33%), Positives = 51/111 (45%), Gaps = 3/111 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + +K LD G + +D EG LH A +LLEAGA V + N L Sbjct: 541 GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL 600 Query: 463 HYAAGYGRKECVDLLLK---HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G + +LL V + DG T + +A LN+ EV +LL Sbjct: 601 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELL 651 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/116 (27%), Positives = 52/116 (44%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G A+ + + + LH A G L+ + LL+ G D +TPLH A R + Sbjct: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDI 578 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLIDPK 263 + +LL+ GA V + N +G + A L +++L SK P ++D K Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL------SKLPRPWIVDEK 628 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/52 (40%), Positives = 30/52 (57%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 G AN D ++V + ALH A + +L+ AGA +D DK+ +TPLH A Sbjct: 655 GNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706 Score = 37.4 bits (85), Expect = 0.039 Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 11/116 (9%) Frame = -3 Query: 634 EGLKKALDGGANKDEE-----DVE------GRRALHFACGYGELKCAEILLEAGAAVDAL 488 E +K A +G K E+ DV+ G A+ A G + ++LL+ V+A Sbjct: 434 ELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 DK+ + +H+AA +++L + A + +N +TP+ +A +VVK L Sbjct: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTL 549
>MIB1_HUMAN (Q86YT6) Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb| homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) Length = 1006 Score = 58.9 bits (141), Expect = 1e-08 Identities = 35/108 (32%), Positives = 54/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + LK L + + ED +G RA+H A E E+L A ++A +K + TPL Sbjct: 475 GHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPL 534 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A G + V LL G LQ+ +G TP+ A +D+++ +L Sbjct: 535 HIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/81 (35%), Positives = 45/81 (55%), Gaps = 1/81 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLL 419 DE+ +G ALH A ++ AE+L+ G A +D + N+ T LH A + V LL Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685 Query: 418 LKHGAAVMLQNLDGKTPIEVA 356 ++ GA + +Q+ DG TP+ A Sbjct: 686 VRAGAKLDIQDKDGDTPLHEA 706 Score = 47.0 bits (110), Expect = 5e-05 Identities = 37/111 (33%), Positives = 51/111 (45%), Gaps = 3/111 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + +K LD G + +D EG LH A +LLEAGA V + N L Sbjct: 541 GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL 600 Query: 463 HYAAGYGRKECVDLLLK---HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G + +LL V + DG T + +A LN+ EV +LL Sbjct: 601 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELL 651 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/116 (27%), Positives = 52/116 (44%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G A+ + + + LH A G L+ + LL+ G D +TPLH A R + Sbjct: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDI 578 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLIDPK 263 + +LL+ GA V + N +G + A L +++L SK P ++D K Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL------SKLPRPWIVDEK 628 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/52 (40%), Positives = 30/52 (57%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 G AN D ++V + ALH A + +L+ AGA +D DK+ +TPLH A Sbjct: 655 GNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706 Score = 37.4 bits (85), Expect = 0.039 Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 11/116 (9%) Frame = -3 Query: 634 EGLKKALDGGANKDEE-----DVE------GRRALHFACGYGELKCAEILLEAGAAVDAL 488 E +K A +G K E+ DV+ G A+ A G + ++LL+ V+A Sbjct: 434 ELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 DK+ + +H+AA +++L + A + +N +TP+ +A +VVK L Sbjct: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTL 549
>PP16A_HUMAN (Q96I34) Protein phosphatase 1 regulatory subunit 16A (Myosin| phosphatase-targeting subunit 3) Length = 528 Score = 58.5 bits (140), Expect = 2e-08 Identities = 34/94 (36%), Positives = 50/94 (53%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 D E +++ L G + D + +G ALH C + + LLEAGA ++A D TPLH Sbjct: 83 DLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLH 142 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEV 359 AA G V+LL+ GA ++ N DG P ++ Sbjct: 143 AAATCGHLHLVELLIASGANLLAVNTDGNMPYDL 176 Score = 54.7 bits (130), Expect = 2e-07 Identities = 35/106 (33%), Positives = 57/106 (53%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 + ++ L GA+ G LH A G + A +LLE A++ A D++ PLH A Sbjct: 213 DDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAA 272 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 A +G+ V+LL+ HGA + ++L +TP++V ++ KLLE Sbjct: 273 AYWGQVPLVELLVAHGADLNAKSLMDETPLDVC--GDEEVRAKLLE 316 Score = 32.7 bits (73), Expect = 0.96 Identities = 20/70 (28%), Positives = 35/70 (50%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +++ L+ GAN + D E LH A G L E+L+ +GA + A++ + N P Sbjct: 118 EMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLC 177 Query: 454 AGYGRKECVD 425 +C++ Sbjct: 178 DDEQTLDCLE 187
>INVS_MOUSE (O89019) Inversin (Inversion of embryo turning protein)| (Nephrocystin-2) Length = 1062 Score = 58.5 bits (140), Expect = 2e-08 Identities = 34/98 (34%), Positives = 53/98 (54%), Gaps = 2/98 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ +K L AN ++D+E LH + + KC +LL+ A VD DKNK T Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH++A Y E LL+KH + + + +++GK P+ A Sbjct: 152 ALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 189 Score = 55.5 bits (132), Expect = 1e-07 Identities = 36/109 (33%), Positives = 58/109 (53%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GD L++ + G A +D+ED GR L + + CA+ LL+AGA V+ D ++ T Sbjct: 25 GDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTA 84 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH AA G + LLL A M ++L+ TP+ ++ + + + LL Sbjct: 85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALL 133 Score = 53.5 bits (127), Expect = 5e-07 Identities = 32/89 (35%), Positives = 47/89 (52%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A G + ++LL+ A VDA D K+TPL A G ++ + L+K G Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 413 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V L + DG + + A L +V ++L Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQIL 442 Score = 50.8 bits (120), Expect = 3e-06 Identities = 29/96 (30%), Positives = 49/96 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G +K LD A D DV L AC G + L++ GA VD +D++ ++ L Sbjct: 368 GHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLL 427 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H+AA G + +L+++ +Q+ G+TP++ A Sbjct: 428 HWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463 Score = 50.4 bits (119), Expect = 4e-06 Identities = 26/73 (35%), Positives = 43/73 (58%), Gaps = 2/73 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 ++ A+ + +D EGR ALH++C G L ++LL+ A + ++ N+ TPL YA Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535 Query: 442 RKECVDLLLKHGA 404 R E + +L+HGA Sbjct: 536 RHEVIQFMLEHGA 548 Score = 49.7 bits (117), Expect = 8e-06 Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A+ + ++ N + +D GR L A G + C +L+E A + DK T L Sbjct: 434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493 Query: 463 HYAAGYGRKECVDLLLKHGA--AVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H++ G + + LLL A M N + TP++ A L + EV++ + Sbjct: 494 HWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFM 543 Score = 49.3 bits (116), Expect = 1e-05 Identities = 31/109 (28%), Positives = 54/109 (49%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + ++ + GGA D D +G LH+A G +IL+E + D TP Sbjct: 400 MGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+ +L+++ A +Q+ +G+T + + N + +KLL Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/94 (32%), Positives = 48/94 (51%), Gaps = 2/94 (2%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLLL- 416 +D EGR LHFA G L ++L + + + D TPLH+AA G + V LLL Sbjct: 217 QDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++ + + + G TP+ A ++ E VK+ Q Sbjct: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQ 310 Score = 40.0 bits (92), Expect = 0.006 Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 2/101 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ ++ D R ALH A G + ++LL A D + TPLH + + Sbjct: 68 LKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSP 127 Query: 436 ECVDLLLKHGA--AVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +C+ LLLK A V Q+ + +T + + + E KLL Sbjct: 128 KCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLL 168 Score = 39.3 bits (90), Expect = 0.010 Identities = 26/86 (30%), Positives = 40/86 (46%), Gaps = 1/86 (1%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 R LH+A G + +LLE + D TPLHYAA E V + L+H + Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVK 315 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 +L+G+T A D+V++ + Sbjct: 316 DDSDLEGRTSFMWAAGKGNDDVLRTM 341 Score = 33.5 bits (75), Expect = 0.56 Identities = 23/98 (23%), Positives = 45/98 (45%), Gaps = 6/98 (6%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY------GRKE 434 D +D + ALH++ Y + A++L++ + + D PLH+AA + Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 C+ + + Q+ +G+TP+ A + VV +L Sbjct: 203 CILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240 Score = 33.1 bits (74), Expect = 0.73 Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 2/91 (2%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD--LLLK 413 D +G LH+A + ++ L+ + D D T +AAG G + + L LK Sbjct: 286 DSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLK 345 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + + G T + A L+ VKLL Sbjct: 346 SDIDINMSDKYGGTALHAAALSGHVSTVKLL 376
>AKR1_MORAP (Q9UVH3) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) (Fragment) Length = 559 Score = 58.5 bits (140), Expect = 2e-08 Identities = 30/81 (37%), Positives = 45/81 (55%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D G +L +A G+ +ILL+ GA VD D+ TPLH+A G +EC+ +L Sbjct: 37 DTADTLGHTSLMWAAYQGDSLSVQILLKHGARVDTKDREGFTPLHWAVVKGNRECLSKIL 96 Query: 415 KHGAAVMLQNLDGKTPIEVAK 353 GA + + GKTP+++ K Sbjct: 97 MAGADIKAGDKSGKTPVDMIK 117 Score = 43.5 bits (101), Expect = 5e-04 Identities = 31/86 (36%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +D +G ALH A LL AG VD D +T L +AA G V +LLK Sbjct: 5 QDSQGFNALHLATHSSNAMLVLYLLMAGEMPVDTADTLGHTSLMWAAYQGDSLSVQILLK 64 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDE 335 HGA V ++ +G TP+ A + E Sbjct: 65 HGARVDTKDREGFTPLHWAVVKGNRE 90 Score = 40.8 bits (94), Expect = 0.004 Identities = 23/60 (38%), Positives = 33/60 (55%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD+ ++ L GA D +D EG LH+A G +C +L AGA + A DK+ TP+ Sbjct: 54 GDSLSVQILLKHGARVDTKDREGFTPLHWAVVKGNRECLSKILMAGADIKAGDKSGKTPV 113
>NOTC4_HUMAN (Q99466) Neurogenic locus notch homolog protein 4 precursor (Notch 4)| (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain] Length = 2003 Score = 58.5 bits (140), Expect = 2e-08 Identities = 37/96 (38%), Positives = 50/96 (52%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ D G+ ALH+A + A LL+AGA DA D + TPL AA G E Sbjct: 1725 ADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQ 1784 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 LLL GAA L++ G P +VA + +++ LLE Sbjct: 1785 LLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLE 1820 Score = 49.7 bits (117), Expect = 8e-06 Identities = 38/111 (34%), Positives = 53/111 (47%), Gaps = 2/111 (1%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDV-EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +G E + LDGGA V G LH A + A LLEAGA + D+ T Sbjct: 1610 LGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRT 1669 Query: 469 PLHYAAGYGRKECVDLLLK-HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH A +E LLL+ AV + DG TP+ +A + +++V+ L Sbjct: 1670 PLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEEL 1720 Score = 41.6 bits (96), Expect = 0.002 Identities = 32/105 (30%), Positives = 53/105 (50%), Gaps = 2/105 (1%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAG-AAVDALDKNKNTPLHYAAG 449 ++ L+ GAN ++ D GR LH A + ++LL + AVDA ++ TPL AA Sbjct: 1651 RRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAAR 1710 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 ++ V+ L+ A V ++ GKT + A +N+ LL+ Sbjct: 1711 LAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQ 1755 Score = 34.3 bits (77), Expect = 0.33 Identities = 20/65 (30%), Positives = 32/65 (49%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +V +A + L GA+KD +D + L A G ++ A++LL GAA + D+ Sbjct: 1743 AVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLA 1802 Query: 469 PLHYA 455 P A Sbjct: 1803 PADVA 1807
>AKR1_YARLI (Q6C520) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 702 Score = 58.5 bits (140), Expect = 2e-08 Identities = 37/112 (33%), Positives = 57/112 (50%), Gaps = 1/112 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 + GA+ DV+G ALH A + LL G VD D N T LH+AA G Sbjct: 138 IQNGADPLRSDVQGYNALHLATHSSNVMLLVYLLHQGLPVDCQDPNGRTALHWAAYQGDA 197 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLN-SQDEVVKLLEQDVFL*SKPSD 284 VD+LL+ G+ V + + G P+ +N S++ + +L+E+ + +K SD Sbjct: 198 LSVDVLLRWGSDVKITDTQGFLPLHWGIVNGSRNSLARLIEEGSDMYAKSSD 249 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/101 (29%), Positives = 52/101 (51%), Gaps = 1/101 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G D +D GR ALH+A G+ ++LL G+ V D PLH+ G + Sbjct: 171 LHQGLPVDCQDPNGRTALHWAAYQGDALSVDVLLRWGSDVKITDTQGFLPLHWGIVNGSR 230 Query: 436 ECVDLLLKHGAAVMLQNLDGKTP-IEVAKLNSQDEVVKLLE 317 + L++ G+ + ++ DGKTP + A++N+ ++ L+ Sbjct: 231 NSLARLIEEGSDMYAKSSDGKTPHVMAAEMNTTAQLEGALD 271 Score = 42.7 bits (99), Expect = 0.001 Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 2/102 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVE-GRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-T 470 G+ +K+ + G+ + E G ALH+A + + L+E GA VDA N T Sbjct: 61 GNTAEVKRLCESGSYSVLDTAEDGVTALHWAAVNNRISTCQYLVEQGAVVDAKGGQLNGT 120 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 PLH+A G V L+++GA + ++ G + +A +S Sbjct: 121 PLHWACRRGLVYIVHYLIQNGADPLRSDVQGYNALHLATHSS 162
>BARD1_MOUSE (O70445) BRCA1-associated RING domain protein 1 (BARD-1)| Length = 765 Score = 58.5 bits (140), Expect = 2e-08 Identities = 32/94 (34%), Positives = 49/94 (52%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD ++ L G + + +D G LH AC +G LK E+LL+ A V+ ++PL Sbjct: 427 GDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKVVELLLQHNALVNTPGYQNDSPL 486 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 H A G + V +LL HGA+ N+ G P++ Sbjct: 487 HDAVKSGHIDIVKVLLSHGASRNAVNIFGVRPVD 520 Score = 49.3 bits (116), Expect = 1e-05 Identities = 30/99 (30%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G + + G LH A G++ E LL+ G + D TPLH A +G Sbjct: 403 LSSGMPARKRNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHL 462 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V+LLL+H A V +P+ A + ++VK+L Sbjct: 463 KVVELLLQHNALVNTPGYQNDSPLHDAVKSGHIDIVKVL 501
>IKBE_MOUSE (O54910) NF-kappa-B inhibitor epsilon (NF-kappa-BIE)| (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E) Length = 364 Score = 58.5 bits (140), Expect = 2e-08 Identities = 36/89 (40%), Positives = 49/89 (55%), Gaps = 1/89 (1%) Frame = -3 Query: 616 LDGGANKD-EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 L GA+ D +E G+ ALH A E + LL+AGA VDA N TPLH AAG G Sbjct: 254 LQNGADIDVQEGTSGKTALHLAVETQERSLVQFLLQAGARVDARMLNGCTPLHLAAGRGL 313 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 L + GA +L N++ +TP ++A+ Sbjct: 314 NSISSTLCEAGADSLLLNVEDETPQDLAE 342 Score = 38.1 bits (87), Expect = 0.023 Identities = 34/109 (31%), Positives = 50/109 (45%), Gaps = 11/109 (10%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLE--------AGAAVDALDKNKN--TPLHY 458 GA++ +D G ALH AC L CA LLE +D KN LH Sbjct: 181 GASRILQDQHGDTALHVACRRQNLACACCLLEEQPEPGRQLSHPLDLQLKNWQGLACLHI 240 Query: 457 AAGYGRKECVDLLLKHGAAVMLQ-NLDGKTPIEVAKLNSQDEVVKLLEQ 314 A + ++LLL++GA + +Q GKT + +A + +V+ L Q Sbjct: 241 ATLQRNQPLIELLLQNGADIDVQEGTSGKTALHLAVETQERSLVQFLLQ 289
>MTPN_RAT (P62775) Myotrophin (V-1 protein) (Granule cell differentiation| protein) Length = 117 Score = 58.5 bits (140), Expect = 2e-08 Identities = 38/110 (34%), Positives = 57/110 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + +K + G + + GR+ LH+A G+L+ E LL GA ++A DK+ TPL Sbjct: 12 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 71 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G CV LLL GA ++ DG T +E + ++ +K L Q Sbjct: 72 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEA----TDNQAIKALLQ 117
>MTPN_MOUSE (P62774) Myotrophin (V-1 protein) (Granule cell differentiation| protein) Length = 117 Score = 58.5 bits (140), Expect = 2e-08 Identities = 38/110 (34%), Positives = 57/110 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + +K + G + + GR+ LH+A G+L+ E LL GA ++A DK+ TPL Sbjct: 12 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 71 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G CV LLL GA ++ DG T +E + ++ +K L Q Sbjct: 72 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEA----TDNQAIKALLQ 117
>ASB7_MOUSE (Q91ZU0) Ankyrin repeat and SOCS box protein 7 (ASB-7)| Length = 318 Score = 58.2 bits (139), Expect = 2e-08 Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 4/114 (3%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDK-NKN 473 + GD ++K L+ G + + D G LHF+ G+ +C + LE GA D Sbjct: 23 AAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGF 82 Query: 472 TPLHYAAGYGRKECVDLLLK---HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LHYAA +GR L+L+ + ++ DG TP+ VA +D V+LL Sbjct: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136 Score = 57.8 bits (138), Expect = 3e-08 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 4/103 (3%) Frame = -3 Query: 616 LDGGANKDEED-VEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN---TPLHYAAG 449 L+ GA+ +D + G ALH+A +G + A ++LE+ D ++ N TPLH AA Sbjct: 67 LEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAH 126 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 YGR V LLL+ A V + G TP+++A + + VK+L Sbjct: 127 YGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169 Score = 45.4 bits (106), Expect = 1e-04 Identities = 26/65 (40%), Positives = 31/65 (47%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G LH A YG +LLE A VD L TPL A R CV +LL H A Sbjct: 116 DGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175 Query: 400 VMLQN 386 + +QN Sbjct: 176 IDIQN 180 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 1/80 (1%) Frame = -3 Query: 556 ACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL-D 380 A G++ +LE G + + D N T LH++A G++ CV + L+HGA +++L Sbjct: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 G T + A ++ + + +L+ Sbjct: 81 GFTALHYAAMHGRARIARLM 100 Score = 31.6 bits (70), Expect = 2.1 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 1/92 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTPLHYAA 452 +K LD AN D ++ L +A + L+ GA + ++ TPLH +A Sbjct: 166 VKILLDHNANID---IQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSA 222 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 C +L +GA +N +G+TP+ V+ Sbjct: 223 LRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
>ASB7_MACFA (Q9BGT9) Ankyrin repeat and SOCS box protein 7 (ASB-7)| Length = 318 Score = 58.2 bits (139), Expect = 2e-08 Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 4/114 (3%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDK-NKN 473 + GD ++K L+ G + + D G LHF+ G+ +C + LE GA D Sbjct: 23 AAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGF 82 Query: 472 TPLHYAAGYGRKECVDLLLK---HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LHYAA +GR L+L+ + ++ DG TP+ VA +D V+LL Sbjct: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136 Score = 57.8 bits (138), Expect = 3e-08 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 4/103 (3%) Frame = -3 Query: 616 LDGGANKDEED-VEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN---TPLHYAAG 449 L+ GA+ +D + G ALH+A +G + A ++LE+ D ++ N TPLH AA Sbjct: 67 LEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAH 126 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 YGR V LLL+ A V + G TP+++A + + VK+L Sbjct: 127 YGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169 Score = 45.4 bits (106), Expect = 1e-04 Identities = 26/65 (40%), Positives = 31/65 (47%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G LH A YG +LLE A VD L TPL A R CV +LL H A Sbjct: 116 DGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175 Query: 400 VMLQN 386 + +QN Sbjct: 176 IDIQN 180 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 1/80 (1%) Frame = -3 Query: 556 ACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL-D 380 A G++ +LE G + + D N T LH++A G++ CV + L+HGA +++L Sbjct: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 G T + A ++ + + +L+ Sbjct: 81 GFTALHYAAMHGRARIARLM 100 Score = 33.5 bits (75), Expect = 0.56 Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 1/92 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTPLHYAA 452 +K LD AN D ++ L +A + L+ GA D ++ TPLH +A Sbjct: 166 VKILLDHNANID---IQNGFLLRYAVIKSNHSYCRMFLQRGADTDLGRLEDGQTPLHLSA 222 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 C +L +GA +N +G+TP+ V+ Sbjct: 223 LRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
>ASB7_HUMAN (Q9H672) Ankyrin repeat and SOCS box protein 7 (ASB-7)| Length = 318 Score = 58.2 bits (139), Expect = 2e-08 Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 4/114 (3%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDK-NKN 473 + GD ++K L+ G + + D G LHF+ G+ +C + LE GA D Sbjct: 23 AAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGF 82 Query: 472 TPLHYAAGYGRKECVDLLLK---HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LHYAA +GR L+L+ + ++ DG TP+ VA +D V+LL Sbjct: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136 Score = 57.8 bits (138), Expect = 3e-08 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 4/103 (3%) Frame = -3 Query: 616 LDGGANKDEED-VEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN---TPLHYAAG 449 L+ GA+ +D + G ALH+A +G + A ++LE+ D ++ N TPLH AA Sbjct: 67 LEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAH 126 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 YGR V LLL+ A V + G TP+++A + + VK+L Sbjct: 127 YGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169 Score = 45.4 bits (106), Expect = 1e-04 Identities = 26/65 (40%), Positives = 31/65 (47%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G LH A YG +LLE A VD L TPL A R CV +LL H A Sbjct: 116 DGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175 Query: 400 VMLQN 386 + +QN Sbjct: 176 IDIQN 180 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 1/80 (1%) Frame = -3 Query: 556 ACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL-D 380 A G++ +LE G + + D N T LH++A G++ CV + L+HGA +++L Sbjct: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 G T + A ++ + + +L+ Sbjct: 81 GFTALHYAAMHGRARIARLM 100 Score = 31.6 bits (70), Expect = 2.1 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 1/92 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTPLHYAA 452 +K LD AN D ++ L +A + L+ GA + ++ TPLH +A Sbjct: 166 VKILLDHNANID---IQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSA 222 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 C +L +GA +N +G+TP+ V+ Sbjct: 223 LRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
>MTPN_CHICK (Q91955) Myotrophin (V-1 protein) (Granule cell differentiation| protein) Length = 118 Score = 58.2 bits (139), Expect = 2e-08 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + +K + G + + GR+ LH+A G+L+ E LL GA ++A DK+ TPL Sbjct: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHNITPL 72 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G CV LLL GA ++ DG T E + ++ +K L Q Sbjct: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEA----TDNQAIKTLLQ 118
>PYX_DROME (Q9W0T5) Transient receptor potential channel pyrexia| Length = 956 Score = 58.2 bits (139), Expect = 2e-08 Identities = 36/89 (40%), Positives = 47/89 (52%), Gaps = 1/89 (1%) Frame = -3 Query: 583 VEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGA 404 +E R ALH+A + C EILL+ GA + TPLH A+ G +CV LLL H A Sbjct: 197 IEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNA 256 Query: 403 AVMLQNLDGK-TPIEVAKLNSQDEVVKLL 320 V Q +GK T + +A N E +LL Sbjct: 257 DVRSQFGEGKVTALHLAAENDYVECARLL 285 Score = 50.4 bits (119), Expect = 4e-06 Identities = 35/97 (36%), Positives = 47/97 (48%), Gaps = 1/97 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA-LDKNKNTPLHYAAGYGRKEC 431 GA+ + V LH A G KC ++LL A V + + K T LH AA EC Sbjct: 222 GADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVEC 281 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LLL+H A V +N +TP+ +A L+ V LL Sbjct: 282 ARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLL 318 Score = 48.9 bits (115), Expect = 1e-05 Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 1/99 (1%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGR-RALHFACGYGELKCAEILLEAGAAVDALDKNKN 473 + G A+ ++ L A+ + EG+ ALH A ++CA +LLE A VD + + Sbjct: 241 AAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDCRNASHQ 300 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 TPLH A VDLL+ +GA V DG+T + A Sbjct: 301 TPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAA 339 Score = 45.4 bits (106), Expect = 1e-04 Identities = 38/113 (33%), Positives = 53/113 (46%), Gaps = 13/113 (11%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFAC--GYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKE 434 GAN + +GR ALH A L C LL+AGA V+ D TPLH AA Sbjct: 322 GANVNAVYRDGRTALHAAIVKQSRSLDCCNALLKAGADVNKADNYGYTPLHIAALNEFSS 381 Query: 433 CVDLLLKHGAAVMLQNLDG----------KTPIEVAKLNSQ-DEVVKLLEQDV 308 CV ++HGA + + DG +TP + KL + D +K +Q++ Sbjct: 382 CVYTFIEHGADITART-DGRVSALSFIVRRTPEIIPKLMQKLDSSIKANDQEI 433 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 1/70 (1%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TPLHYAAGYGRKECV 428 A+ + D GR LHFAC A++LL+ GA + D K T LH AA EC+ Sbjct: 124 ADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDARKEVTSLHCAASSKSVECI 183 Query: 427 DLLLKHGAAV 398 LLL+ A++ Sbjct: 184 LLLLRRKASI 193
>ASB3_MOUSE (Q9WV72) Ankyrin repeat and SOCS box protein 3 (ASB-3)| Length = 525 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/110 (38%), Positives = 58/110 (52%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+AE +K L GA+++ +D G L A YG+L+ IL+ +GA V+ +K TPL Sbjct: 157 GNAETIKLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPL 216 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQ-NLDG-KTPIEVAKLNSQDEVVKLL 320 AA G +CV+LLL GA L N D + PI A E + LL Sbjct: 217 FIAAQEGHTKCVELLLSSGADPDLYCNEDNWQLPIHAAAQMGHTETLDLL 266 Score = 56.2 bits (134), Expect = 8e-08 Identities = 38/109 (34%), Positives = 55/109 (50%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKD-EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G + LK L GAN + + G +LH A G + ++LL+ GA + D TP Sbjct: 123 GRIDVLKLLLQHGANVNGSHSMSGWNSLHQASFQGNAETIKLLLKQGADRECQDDFGITP 182 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA YG+ E + +L+ GA V Q LD TP+ +A + V+LL Sbjct: 183 LFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 231 Score = 52.8 bits (125), Expect = 9e-07 Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 1/88 (1%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 EG ALH A G K +ILLEAGA + + TPL A GR + + LLL+HGA Sbjct: 78 EGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGAN 137 Query: 400 VM-LQNLDGKTPIEVAKLNSQDEVVKLL 320 V ++ G + A E +KLL Sbjct: 138 VNGSHSMSGWNSLHQASFQGNAETIKLL 165 Score = 49.3 bits (116), Expect = 1e-05 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 2/113 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDAL--DKNKNT 470 G E + + GAN + + ++ L A G KC E+LL +GA D + N Sbjct: 190 GKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWQL 249 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 P+H AA G E +DLL+ D +P+ A ++E +++L Q+ Sbjct: 250 PIHAAAQMGHTETLDLLIPRTNRACDTEPDKVSPVYSAVFGGREECLEMLLQN 302 Score = 41.2 bits (95), Expect = 0.003 Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 3/113 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA---VDALDKNKN 473 G+ + L+K L G + D D G +H A + ++C ++L+ ++ + A Sbjct: 21 GNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKTFEGF 80 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LH A G + +LL+ GA L+ TP+ +A + + +V+KLL Q Sbjct: 81 CALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQ 133
>AKR1_DEBHA (Q6BP80) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 821 Score = 58.2 bits (139), Expect = 2e-08 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 DE D R +LH+A G+L LL+ GA V +DKN PLH+A G K + +L Sbjct: 284 DESDNCDRTSLHWAAYQGDLLTINALLKFGADVSKIDKNLFIPLHWAFMKGYKTVLKVLA 343 Query: 415 KHGAAVMLQNLDGKTPIEVAK-LNSQDEVVKLLEQ 314 G+ + +N GK EVAK +N D +K+L++ Sbjct: 344 GAGSNIFAKNDQGKDSFEVAKDMNCYDTWIKVLKE 378
>INVSA_XENLA (Q71S22) Inversin-A| Length = 1007 Score = 58.2 bits (139), Expect = 2e-08 Identities = 36/99 (36%), Positives = 50/99 (50%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 LD + D G ALH A G++ ILLE VDA+D K+T L A G + Sbjct: 340 LDPELEVNRTDKYGGTALHAASLSGQITTVRILLENRVQVDAVDVMKHTALFRACEMGHR 399 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E + L+K GA V L + DG++P+ A L V ++L Sbjct: 400 EVISTLIKGGAKVHLVDKDGRSPLHWAALGGNANVCQIL 438 Score = 57.4 bits (137), Expect = 4e-08 Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+A + ++ N D +D EGR L A G + C E+L+E A + DKN T L Sbjct: 430 GNANVCQILIENNINPDAQDYEGRTPLQCAAYGGYIGCMEVLMENKADPNIQDKNGRTAL 489 Query: 463 HYAAGYGRKECVDLLLKHGA-AVMLQNLDGK-TPIEVAKLNSQDEVVKLL 320 H++ G + V LLL + A ++N + + TP++ A L EV++ + Sbjct: 490 HWSCNNGYLDAVKLLLGYSAFPNQMENTEERYTPLDYALLGGHQEVIQFM 539 Score = 54.7 bits (130), Expect = 2e-07 Identities = 35/109 (32%), Positives = 55/109 (50%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E + + GGA D +GR LH+A G +IL+E DA D TP Sbjct: 396 MGHREVISTLIKGGAKVHLVDKDGRSPLHWAALGGNANVCQILIENNINPDAQDYEGRTP 455 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA G C+++L+++ A +Q+ +G+T + + N + VKLL Sbjct: 456 LQCAAYGGYIGCMEVLMENKADPNIQDKNGRTALHWSCNNGYLDAVKLL 504 Score = 52.4 bits (124), Expect = 1e-06 Identities = 30/98 (30%), Positives = 52/98 (53%), Gaps = 2/98 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE--AGAAVDALDKNKNT 470 G+ LK L A+ D+ A+H + + + +C ++L+ VDA D+ K T Sbjct: 88 GNHRLLKLLLSRKADCTHRDLRDITAVHLSTRHQDTRCLALILKYTPPGQVDAQDQRKQT 147 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH++A Y R V LL++HG+ + + + +GK P+ A Sbjct: 148 ALHWSAYYNRPRHVRLLVRHGSNIGIPDTEGKIPLHWA 185 Score = 49.7 bits (117), Expect = 8e-06 Identities = 28/96 (29%), Positives = 47/96 (48%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G ++ L+ D DV AL AC G + L++ GA V +DK+ +PL Sbjct: 364 GQITTVRILLENRVQVDAVDVMKHTALFRACEMGHREVISTLIKGGAKVHLVDKDGRSPL 423 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H+AA G +L+++ Q+ +G+TP++ A Sbjct: 424 HWAALGGNANVCQILIENNINPDAQDYEGRTPLQCA 459 Score = 46.2 bits (108), Expect = 8e-05 Identities = 24/73 (32%), Positives = 41/73 (56%), Gaps = 2/73 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYG 443 ++ A+ + +D GR ALH++C G L ++LL A + ++ + TPL YA G Sbjct: 472 MENKADPNIQDKNGRTALHWSCNNGYLDAVKLLLGYSAFPNQMENTEERYTPLDYALLGG 531 Query: 442 RKECVDLLLKHGA 404 +E + +L+HGA Sbjct: 532 HQEVIQFMLEHGA 544 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 6/98 (6%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC---VD 425 D +D + ALH++ Y + +L+ G+ + D PLH+AAG+ E V Sbjct: 139 DAQDQRKQTALHWSAYYNRPRHVRLLVRHGSNIGIPDTEGKIPLHWAAGHKDPEAALTVR 198 Query: 424 LLLKHGAAVML---QNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ L Q+ +G+TP+ +A + EVV+LL Sbjct: 199 CLLEAAPTESLLNWQDYEGRTPLHLAVGDGNQEVVRLL 236 Score = 42.7 bits (99), Expect = 0.001 Identities = 28/92 (30%), Positives = 44/92 (47%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D+ED GR L ++ CAE LL+ GA V+ D++ T LH AA G + LLL Sbjct: 38 DQEDQLGRTPLMYSVLGDRRSCAEALLKHGAQVNHPDRSGRTALHLAAQTGNHRLLKLLL 97 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A ++L T + ++ + + L+ Sbjct: 98 SRKADCTHRDLRDITAVHLSTRHQDTRCLALI 129 Score = 42.0 bits (97), Expect = 0.002 Identities = 21/69 (30%), Positives = 36/69 (52%) Frame = -3 Query: 526 EILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLN 347 +++ + +D D+ TPL Y+ R+ C + LLKHGA V + G+T + +A Sbjct: 28 KLIASSPEVIDQEDQLGRTPLMYSVLGDRRSCAEALLKHGAQVNHPDRSGRTALHLAAQT 87 Query: 346 SQDEVVKLL 320 ++KLL Sbjct: 88 GNHRLLKLL 96 Score = 41.6 bits (96), Expect = 0.002 Identities = 35/101 (34%), Positives = 47/101 (46%), Gaps = 2/101 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA-LDKNKNTPLHYAAGYGRKEC 431 G N D R LH+A G A +LLE + + D TPLHYAA + Sbjct: 241 GCNVAPYDNLFRTPLHWAALLGYTPIAHLLLETNNSPNIPSDSQGATPLHYAAQGNCPDT 300 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQD 311 V +LL H + +L+G+T A DEVV+ +LE D Sbjct: 301 VRVLLSHISVRDEADLEGRTAFMWAAGKGSDEVVRTMLELD 341 Score = 41.6 bits (96), Expect = 0.002 Identities = 38/115 (33%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCA---EILLEAGAAVDAL---DKNKNTPLHYAAGY 446 G+N D EG+ LH+A G+ + + A LLEA L D TPLH A G Sbjct: 168 GSNIGIPDTEGKIPLHWAAGHKDPEAALTVRCLLEAAPTESLLNWQDYEGRTPLHLAVGD 227 Query: 445 GRKECVDLLLKH-GAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSD 284 G +E V LL + G V + +TP+ A L + LL + + PSD Sbjct: 228 GNQEVVRLLTSYRGCNVAPYDNLFRTPLHWAALLGYTPIAHLLLETNNSPNIPSD 282
>ASB16_MOUSE (Q8VHS5) Ankyrin repeat and SOCS box protein 16 (ASB-16)| Length = 453 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/85 (40%), Positives = 50/85 (58%), Gaps = 1/85 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTPLHYAAGYGRKEC 431 GA + EG LH L+CA++LLEAGA+V+ A +++ TPLH AA G ++ Sbjct: 166 GAKANVSSEEGMTPLHLCTSPESLQCAKLLLEAGASVNVASQESEVTPLHVAAARGLEQH 225 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVA 356 V L L++GA V L+ G+T + A Sbjct: 226 VALYLQNGADVALRTSQGETALNAA 250 Score = 51.2 bits (121), Expect = 3e-06 Identities = 40/115 (34%), Positives = 54/115 (46%), Gaps = 12/115 (10%) Frame = -3 Query: 646 VGDAEGLKKA----LDGGANKDEEDVEGRRALHFACGYGE--------LKCAEILLEAGA 503 V A GL++ L GA+ +G AL+ AC E A LLEAGA Sbjct: 216 VAAARGLEQHVALYLQNGADVALRTSQGETALNAACAGAEGPGSSRQHEAAARQLLEAGA 275 Query: 502 AVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQD 338 A + ++TPLH A G +LLL+HGA+ + N G TP++ A QD Sbjct: 276 DPQAAGRKRHTPLHNACANGCGGLAELLLRHGASPGVTNGAGHTPMDCALQAVQD 330 Score = 51.2 bits (121), Expect = 3e-06 Identities = 33/100 (33%), Positives = 48/100 (48%), Gaps = 1/100 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA D + GR ALH AC C +LL GA + + TPLH +C Sbjct: 134 GAELDAR-IGGRAALHEACAQAHPDCVRLLLTFGAKANVSSEEGMTPLHLCTSPESLQCA 192 Query: 427 DLLLKHGAAVMLQNLDGK-TPIEVAKLNSQDEVVKLLEQD 311 LLL+ GA+V + + + + TP+ VA ++ V L Q+ Sbjct: 193 KLLLEAGASVNVASQESEVTPLHVAAARGLEQHVALYLQN 232
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 57.8 bits (138), Expect = 3e-08 Identities = 37/105 (35%), Positives = 48/105 (45%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K L G D +D G LH AC G + L EA +D +K TPLH A Sbjct: 560 EVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 619 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G + V L GA+V DGKT ++A+ + V LL Sbjct: 620 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 664 Score = 56.2 bits (134), Expect = 8e-08 Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 2/112 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEI--LLEAGAAVDALDKNKNT 470 G + LK + D +D G ALH A YG A++ L G+ + DK + T Sbjct: 423 GHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEET 482 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 PLH AA +G L + G V ++N +G+TP+ A ++V+ L + Sbjct: 483 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAE 534 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/103 (33%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G+N + +D E LH A +G A+ L EAG V+ ++ TPL A+ G + V Sbjct: 470 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 529 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQDVFL 302 + L +HGA + + DG + +A Q EV+K LL Q F+ Sbjct: 530 ECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 572 Score = 51.6 bits (122), Expect = 2e-06 Identities = 32/96 (33%), Positives = 49/96 (51%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + D +G ALH A +++ + LL G VD D++ NTPLH A G V Sbjct: 536 GADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 595 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L + + + N G+TP+ +A N +VV+ L Sbjct: 596 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 631 Score = 46.6 bits (109), Expect = 6e-05 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ + L+ + G+ D +D G A+++A +G + + L E +D DK+ L Sbjct: 390 GNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMAL 449 Query: 463 HYAAGYGRKEC--VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA YG + V +L G+ +Q+ + +TP+ A + V K L Sbjct: 450 HVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 499 Score = 46.2 bits (108), Expect = 8e-05 Identities = 35/104 (33%), Positives = 48/104 (46%), Gaps = 1/104 (0%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K + G N + ++ EG L A G E L E GA ++A DK+ + LH A Sbjct: 497 KALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR 556 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQDEVVKLLE 317 + E + LL G V Q+ G TP+ VA K + VV L E Sbjct: 557 CQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE 600
>ASB16_HUMAN (Q96NS5) Ankyrin repeat and SOCS box protein 16 (ASB-16)| Length = 453 Score = 57.8 bits (138), Expect = 3e-08 Identities = 35/85 (41%), Positives = 49/85 (57%), Gaps = 1/85 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTPLHYAAGYGRKEC 431 GA + EG LH L+CA++LLEAGA V+ A +++ TPLH AA G ++ Sbjct: 166 GAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQH 225 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVA 356 V L L+HGA V L+ G+T + A Sbjct: 226 VALYLEHGADVGLRTSQGETALNAA 250 Score = 52.4 bits (124), Expect = 1e-06 Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 1/96 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA D V GR ALH AC + C +LL GA + L + TPLH +C Sbjct: 134 GAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA 192 Query: 427 DLLLKHGAAVMLQNLDG-KTPIEVAKLNSQDEVVKL 323 LLL+ GA V L + +TP+ VA ++ V L Sbjct: 193 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228 Score = 50.1 bits (118), Expect = 6e-06 Identities = 39/115 (33%), Positives = 54/115 (46%), Gaps = 12/115 (10%) Frame = -3 Query: 646 VGDAEGLKKA----LDGGANKDEEDVEGRRALHFACGYGE--------LKCAEILLEAGA 503 V A GL++ L+ GA+ +G AL+ AC E A LLEAGA Sbjct: 216 VAAARGLEQHVALYLEHGADVGLRTSQGETALNAACAGAEGPGSCRRHQAAARRLLEAGA 275 Query: 502 AVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQD 338 A + ++TPLH A G +LLL++GA + N G TP++ A QD Sbjct: 276 DARAAGRKRHTPLHNACASGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQD 330 Score = 38.9 bits (89), Expect = 0.013 Identities = 26/82 (31%), Positives = 37/82 (45%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 L A G CA L+ GA +DA + LH A + +CV LLL GA + Sbjct: 115 LAIATARGYTDCARHLIRQGAELDARVGGR-AALHEACARAQFDCVRLLLTFGAKANVLT 173 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 +G TP+ + + + KLL Sbjct: 174 EEGTTPLHLCTIPESLQCAKLL 195
>MTPN_HUMAN (P58546) Myotrophin (V-1 protein)| Length = 117 Score = 57.8 bits (138), Expect = 3e-08 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + +K + G + + GR+ LH+A G+L+ E LL GA ++A DK+ TPL Sbjct: 12 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 71 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G CV LLL GA ++ DG T E + ++ +K L Q Sbjct: 72 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEA----TDNQAIKALLQ 117
>MTPN_CANFA (Q863Z4) Myotrophin| Length = 117 Score = 57.8 bits (138), Expect = 3e-08 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD + +K + G + + GR+ LH+A G+L+ E LL GA ++A DK+ TPL Sbjct: 12 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 71 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A G CV LLL GA ++ DG T E + ++ +K L Q Sbjct: 72 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEA----TDNQAIKALLQ 117
>ASB3_HUMAN (Q9Y575) Ankyrin repeat and SOCS box protein 3 (ASB-3)| Length = 518 Score = 57.4 bits (137), Expect = 4e-08 Identities = 42/109 (38%), Positives = 58/109 (53%), Gaps = 2/109 (1%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE +K L GANK+ +D G L A YG+L+ IL+ +GA V+ +K TPL Sbjct: 158 NAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLF 217 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQ-NLDG-KTPIEVAKLNSQDEVVKLL 320 AA G +CV+LLL GA L N D + PI A +++ LL Sbjct: 218 IAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266 Score = 53.1 bits (126), Expect = 7e-07 Identities = 34/88 (38%), Positives = 46/88 (52%), Gaps = 1/88 (1%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 EG ALH A G K +ILLEAGA +A + TPL A G+ + + LLL+HGA Sbjct: 78 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 137 Query: 400 VM-LQNLDGKTPIEVAKLNSQDEVVKLL 320 V ++ G + A E++KLL Sbjct: 138 VNGSHSMCGWNSLHQASFQENAEIIKLL 165 Score = 51.2 bits (121), Expect = 3e-06 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKD-EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G + L+ L GAN + + G +LH A + ++LL GA + D TP Sbjct: 123 GQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITP 182 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L AA YG+ E + +L+ GA V Q LD TP+ +A + V+LL Sbjct: 183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 231 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/110 (26%), Positives = 50/110 (45%), Gaps = 2/110 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDAL--DKNKNT 470 G E L + GAN + + ++ L A G KC E+LL +GA D + + Sbjct: 190 GKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL 249 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 P+H AA G + +DLL+ L+ +P+ A ++ +++L Sbjct: 250 PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299 Score = 35.0 bits (79), Expect = 0.19 Identities = 19/78 (24%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA---VMLQNLDGK 374 G +K LL+ G +VD D P+H AA + EC+ +L+ ++ + ++ +G Sbjct: 21 GNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGF 80 Query: 373 TPIEVAKLNSQDEVVKLL 320 + +A ++V++L Sbjct: 81 CALHLAASQGHWKIVQIL 98
>PP16B_BOVIN (Q95N27) Protein phosphatase 1 regulatory inhibitor subunit 16B| (TGF-beta-inhibited membrane-associated protein) (bTIMAP) (CAAX box protein TIMAP) Length = 568 Score = 57.4 bits (137), Expect = 4e-08 Identities = 34/97 (35%), Positives = 54/97 (55%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + D D +G LH A G L+ AE+LL+ G VD D + PLH AA +G+ + Sbjct: 219 GQDLDWVDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 +LL+ HGA++ + + PI++ + ++ V LLE Sbjct: 279 ELLVSHGASLSARTSMDEMPIDLCE--EEEFKVLLLE 313 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/96 (33%), Positives = 50/96 (52%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 DAE ++ L + D + +G ALH C + ++LL GA V+A D TPLH Sbjct: 80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLH 139 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 AA G V +L+++GA ++ N DG P ++ + Sbjct: 140 AAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175 Score = 39.7 bits (91), Expect = 0.008 Identities = 22/67 (32%), Positives = 34/67 (50%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 ++ AG +D +D T LH A G +LLL HG V +++ DG P+ A Q Sbjct: 215 MIAAGQDLDWVDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQ 274 Query: 340 DEVVKLL 320 ++ +LL Sbjct: 275 MQMAELL 281 Score = 31.2 bits (69), Expect = 2.8 Identities = 26/98 (26%), Positives = 42/98 (42%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + E AL A + + L+ + D +++ T LH +E V Sbjct: 58 GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLL HGA V ++ + TP+ A +VK+L Q Sbjct: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQ 155
>OSBL1_MOUSE (Q91XL9) Oxysterol-binding protein-related protein 1 (OSBP-related| protein 1) (ORP-1) Length = 950 Score = 57.4 bits (137), Expect = 4e-08 Identities = 41/104 (39%), Positives = 57/104 (54%), Gaps = 10/104 (9%) Frame = -3 Query: 643 GDAEGLKKALDGGANKD---EEDVEGRRA-------LHFACGYGELKCAEILLEAGAAVD 494 G+AE ++K L A + + D +GR LH AC +G + E LL+AGA V+ Sbjct: 16 GNAEEVRKLLAAMARMEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVEDLLKAGAKVN 75 Query: 493 ALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 L+ +TPLH AA GRKE V LLL++ A + N G+T E Sbjct: 76 MLNDMGDTPLHRAAFTGRKELVLLLLEYDADSTVVNGSGQTAKE 119 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 4/78 (5%) Frame = -3 Query: 541 ELKCAEILLEAGAAVDALDKNKN----TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGK 374 +L A +E A +D ++K+ TPLH A +G K+ V+ LLK GA V + N G Sbjct: 23 KLLAAMARMEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVEDLLKAGAKVNMLNDMGD 82 Query: 373 TPIEVAKLNSQDEVVKLL 320 TP+ A + E+V LL Sbjct: 83 TPLHRAAFTGRKELVLLL 100 Score = 39.3 bits (90), Expect = 0.010 Identities = 20/49 (40%), Positives = 31/49 (63%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 V+ D+ NTPLH AA K+CV LL+ GA L+N + + P+++A+ Sbjct: 169 VNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAQ 217
>ACBD6_MOUSE (Q9D061) Acyl-CoA-binding domain-containing protein 6| Length = 282 Score = 57.4 bits (137), Expect = 4e-08 Identities = 32/82 (39%), Positives = 46/82 (56%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D EGR LH+AC G + ++LL+ A ++ D T LHYAA + V+ Sbjct: 183 ADVNMTDEEGRALLHWACDRGHKELVKVLLQYEAGINCQDNEGQTALHYAAACEFLDIVE 242 Query: 424 LLLKHGAAVMLQNLDGKTPIEV 359 LLL+ GA L++ DG P EV Sbjct: 243 LLLQSGADPTLRDQDGCLPEEV 264 Score = 38.5 bits (88), Expect = 0.017 Identities = 26/87 (29%), Positives = 43/87 (49%) Frame = -3 Query: 529 AEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKL 350 A+ + A V+ D+ LH+A G KE V +LL++ A + Q+ +G+T + A Sbjct: 175 AKAIKSKAADVNMTDEEGRALLHWACDRGHKELVKVLLQYEAGINCQDNEGQTALHYAAA 234 Query: 349 NSQDEVVKLLEQDVFL*SKPSDPVLID 269 ++V+LL Q +DP L D Sbjct: 235 CEFLDIVELLLQ------SGADPTLRD 255 Score = 31.2 bits (69), Expect = 2.8 Identities = 26/81 (32%), Positives = 38/81 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L A + +D EG+ ALH+A L E+LL++GA D++ P Sbjct: 203 GHKELVKVLLQYEAGINCQDNEGQTALHYAAACEFLDIVELLLQSGADPTLRDQDGCLPE 262 Query: 463 HYAAGYGRKECVDLLLKHGAA 401 G K LL +H A+ Sbjct: 263 EVT---GCKAVSLLLQRHRAS 280
>FANK1_HUMAN (Q8TC84) Fibronectin type 3 and ankyrin repeat domains protein 1| Length = 345 Score = 57.4 bits (137), Expect = 4e-08 Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 2/98 (2%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TPL-HYAAGYGRKE 434 GA+ D+ G ALH+A G E +++ G VD +D TPL +A G + Sbjct: 200 GASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQR 259 Query: 433 CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ GA V +++ +GKTP+ VA LN+ +E+V+LL Sbjct: 260 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLL 297 Score = 53.9 bits (128), Expect = 4e-07 Identities = 30/77 (38%), Positives = 45/77 (58%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G + A +L++AGA V+ D+N TPL A +E V LLL GA ++N GK + Sbjct: 256 GNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVL 315 Query: 364 EVAKLNSQDEVVKLLEQ 314 E+A++ + VV LLE+ Sbjct: 316 EMARVFDRQSVVSLLEE 332
>AKR1_ASHGO (Q755Y0) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 724 Score = 57.4 bits (137), Expect = 4e-08 Identities = 32/86 (37%), Positives = 48/86 (55%), Gaps = 1/86 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D G+ ALH+A G+ E LL+ A V +D TPLH+A G + L+ Sbjct: 186 DSPDPTGKTALHWAAYQGDPNTVEALLKFDADVRVVDTGGFTPLHWATVKGHPHVLKALI 245 Query: 415 KHGAAVMLQNLDGKTPIEVA-KLNSQ 341 +HG+ V L+N DGK + +A ++N+Q Sbjct: 246 EHGSDVFLKNNDGKNALMIAQEMNTQ 271 Score = 44.3 bits (103), Expect = 3e-04 Identities = 36/109 (33%), Positives = 51/109 (46%), Gaps = 4/109 (3%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGR 440 L+ GA+ D +G LH + E+ +L G VD+ D T LH+AA G Sbjct: 145 LEHGADPLITDRQGYNLLHTSTFSSEVMLITYVLFTGQIPVDSPDPTGKTALHWAAYQGD 204 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ---DVFL 302 V+ LLK A V + + G TP+ A + V+K L + DVFL Sbjct: 205 PNTVEALLKFDADVRVVDTGGFTPLHWATVKGHPHVLKALIEHGSDVFL 253 Score = 39.7 bits (91), Expect = 0.008 Identities = 28/105 (26%), Positives = 49/105 (46%), Gaps = 4/105 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGA---NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKN-K 476 GD + +K ++ G D ++ E LH+A L L+ GA V+ + + Sbjct: 66 GDLKTVKDMIEAGVIDVKADWDEEEQVSGLHWASANNRLNLVRYLIAQGADVNIKGGDLE 125 Query: 475 NTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 TPLH+A+ G V LL+HGA ++ + G + + +S+ Sbjct: 126 ATPLHWASKSGYVYIVHCLLEHGADPLITDRQGYNLLHTSTFSSE 170 Score = 33.5 bits (75), Expect = 0.56 Identities = 28/102 (27%), Positives = 48/102 (47%), Gaps = 4/102 (3%) Frame = -3 Query: 562 HFACGYGELKCAEILLEAG---AAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVML 392 H AC G+LK + ++EAG D ++ + + LH+A+ R V L+ GA V + Sbjct: 60 HAACQRGDLKTVKDMIEAGVIDVKADWDEEEQVSGLHWASANNRLNLVRYLIAQGADVNI 119 Query: 391 QNLD-GKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 + D TP+ A + +V L + +DP++ D Sbjct: 120 KGGDLEATPLHWASKSGYVYIVHCLLE------HGADPLITD 155
>PP16B_HUMAN (Q96T49) Protein phosphatase 1 regulatory inhibitor subunit 16B| (TGF-beta-inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4) Length = 567 Score = 57.0 bits (136), Expect = 5e-08 Identities = 34/97 (35%), Positives = 54/97 (55%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + D D +G LH A G L+ AE+LL+ G VD D + PLH AA +G+ + Sbjct: 219 GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 +LL+ HGA++ + + PI++ + ++ V LLE Sbjct: 279 ELLVSHGASLSARTSMDEMPIDLCE--EEEFKVLLLE 313 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/96 (33%), Positives = 50/96 (52%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 DAE ++ L + D + +G ALH C + ++LL GA V+A D TPLH Sbjct: 80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLH 139 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 AA G V +L+++GA ++ N DG P ++ + Sbjct: 140 AAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175 Score = 40.0 bits (92), Expect = 0.006 Identities = 22/67 (32%), Positives = 34/67 (50%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 ++ AG +D +D T LH A G +LLL HG V +++ DG P+ A Q Sbjct: 215 MIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQ 274 Query: 340 DEVVKLL 320 ++ +LL Sbjct: 275 MQMAELL 281 Score = 31.2 bits (69), Expect = 2.8 Identities = 26/98 (26%), Positives = 42/98 (42%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + E AL A + + L+ + D +++ T LH +E V Sbjct: 58 GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLL HGA V ++ + TP+ A +VK+L Q Sbjct: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQ 155
>SHAN3_RAT (Q9JLU4) SH3 and multiple ankyrin repeat domains 3 (Shank3)| (Proline-rich synapse associated protein 2) (ProSAP2) (SPANK-2) Length = 1815 Score = 57.0 bits (136), Expect = 5e-08 Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 1/108 (0%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRAL-HFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 +A L LD GA+ D +D G L H A G G+ C E+LL A + D+N + Sbjct: 270 NAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEI 329 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H A +G + ++ LL +GA + QN G T + + L +Q+ ++L Sbjct: 330 HQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVL 377 Score = 42.0 bits (97), Expect = 0.002 Identities = 24/78 (30%), Positives = 34/78 (43%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + L+ L GAN ++ G ALH Y + CA +LL GA D + N T Sbjct: 336 GHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAF 395 Query: 463 HYAAGYGRKECVDLLLKH 410 A G E +++ H Sbjct: 396 QVAIIAGNFELAEVIKTH 413
>Y045_METMA (Q8Q0U0) Hypothetical ANK-repeat protein MM0045| Length = 360 Score = 57.0 bits (136), Expect = 5e-08 Identities = 32/99 (32%), Positives = 58/99 (58%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 ++ GA+ + +D G AL +A G +L+E GA+++ D+ T L ++A GRK Sbjct: 253 VNAGADLNLQDKNGNTALIYAADRGYRDIVNLLIEGGASLNIPDEAGLTALMFSAQTGRK 312 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V+LL+K GA + +++ + KT ++A +E+V LL Sbjct: 313 DIVELLIKAGADINIEDKNNKTAADLAAEVGFEEIVDLL 351 Score = 57.0 bits (136), Expect = 5e-08 Identities = 33/99 (33%), Positives = 57/99 (57%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 + GA+ + +D G+ AL A G E+L+ AGA ++ DKN NT L YAA G + Sbjct: 220 IKAGADLNIQDNSGKTALVAATKIGHKGIVELLVNAGADLNLQDKNGNTALIYAADRGYR 279 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + V+LL++ GA++ + + G T + + + ++V+LL Sbjct: 280 DIVNLLIEGGASLNIPDEAGLTALMFSAQTGRKDIVELL 318 Score = 52.8 bits (125), Expect = 9e-07 Identities = 32/96 (33%), Positives = 51/96 (53%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + +D G AL FA G A+ L++AG ++ D+N T L AA ++ Sbjct: 157 GADLNFQDENGETALKFAVKVGYKNIADQLIDAGTDLNIQDENGETALICAADRAHRDIA 216 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL+K GA + +Q+ GKT + A +V+LL Sbjct: 217 ELLIKAGADLNIQDNSGKTALVAATKIGHKGIVELL 252 Score = 50.4 bits (119), Expect = 4e-06 Identities = 32/97 (32%), Positives = 53/97 (54%), Gaps = 1/97 (1%) Frame = -3 Query: 643 GDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G E ++K L + + +D G+ AL A G +L+E+G +D D+N NT Sbjct: 78 GQTENVEKLLRSNKVDVNYQDAYGKTALISAADKGYRDVIGLLIESGPNLDLQDENGNTA 137 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 L AA R + +DLL+K+GA + Q+ +G+T ++ A Sbjct: 138 LISAAKIERGDIIDLLVKNGADLNFQDENGETALKFA 174 Score = 50.1 bits (118), Expect = 6e-06 Identities = 32/99 (32%), Positives = 50/99 (50%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 +D G + + +D G AL A AE+L++AGA ++ D + T L A G K Sbjct: 187 IDAGTDLNIQDENGETALICAADRAHRDIAELLIKAGADLNIQDNSGKTALVAATKIGHK 246 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V+LL+ GA + LQ+ +G T + A ++V LL Sbjct: 247 GIVELLVNAGADLNLQDKNGNTALIYAADRGYRDIVNLL 285 Score = 44.3 bits (103), Expect = 3e-04 Identities = 27/99 (27%), Positives = 49/99 (49%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 ++ G N D +D G AL A ++L++ GA ++ D+N T L +A G K Sbjct: 121 IESGPNLDLQDENGNTALISAAKIERGDIIDLLVKNGADLNFQDENGETALKFAVKVGYK 180 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 D L+ G + +Q+ +G+T + A + ++ +LL Sbjct: 181 NIADQLIDAGTDLNIQDENGETALICAADRAHRDIAELL 219
>CT086_HUMAN (Q9BZ19) Hypothetical protein C20orf86| Length = 240 Score = 56.6 bits (135), Expect = 6e-08 Identities = 29/71 (40%), Positives = 42/71 (59%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 AL+ A G + LLE GA+ + TPLH AA GR +C+ LLL+HGA++ + Sbjct: 118 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 177 Query: 388 NLDGKTPIEVA 356 + G+TPI +A Sbjct: 178 DAKGETPISIA 188 Score = 33.1 bits (74), Expect = 0.73 Identities = 17/51 (33%), Positives = 30/51 (58%) Frame = -3 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 L+ A+ G + V LL+HGA+ + ++ G+TP+ VA + + + LL Q Sbjct: 119 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 169
>ASZ1_CALJA (Q2QLG0) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 477 Score = 56.6 bits (135), Expect = 6e-08 Identities = 33/80 (41%), Positives = 44/80 (55%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ +GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 157 YAARDGHTQVVALLVASGAEVNTQDENGYTALTWAARQGHKSIVLKLLELGANKMLQTKD 216 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ LL Sbjct: 217 GKLPSEIAKRNKHHEIFNLL 236 Score = 31.6 bits (70), Expect = 2.1 Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%) Frame = -3 Query: 544 GELKCAEILLEAGA-AVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTP 368 G++ LL++G +VDA + TPL YAA E V +LL GA + D +T Sbjct: 58 GDVSLVLELLDSGIISVDATFRYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQTI 116 Query: 367 IEVA--KLNSQDEVVKLLEQDVFL*SKPSDP 281 + A S+++++K +E L S+ +DP Sbjct: 117 LITACSAHGSEEQILKCVE---LLLSRNADP 144
>ASB12_MOUSE (Q9D738) Ankyrin repeat and SOCS box protein 12 (ASB-12)| Length = 308 Score = 56.6 bits (135), Expect = 6e-08 Identities = 32/84 (38%), Positives = 45/84 (53%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 L A YG L C ++LLE GA VD+LD TPL A +G ECV +LL+ GA Sbjct: 68 LRLAASYGHLNCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRMLLEAGACPSGSI 127 Query: 385 LDGKTPIEVAKLNSQDEVVKLLEQ 314 + +P+ A S+D +L++ Sbjct: 128 YNNCSPVLTA---SRDGAFAILQE 148 Score = 48.5 bits (114), Expect = 2e-05 Identities = 33/102 (32%), Positives = 49/102 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G +K L+ GA+ D DV+ + L A +G L+C +LLEAGA N + Sbjct: 73 SYGHLNCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRMLLEAGACPSGSIYNNCS 132 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 P+ A+ G + LL HGA N+ K P+ + + S Sbjct: 133 PVLTASRDGAFAILQELLGHGAEA---NVKAKLPVWASNIAS 171 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/51 (41%), Positives = 30/51 (58%) Frame = -3 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPL AA YG CV +LL+HGA V ++ +TP+ A + E V++L Sbjct: 66 TPLRLAASYGHLNCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRML 116
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 56.6 bits (135), Expect = 6e-08 Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 3/114 (2%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S GD + + L+ GA+ D GR + C Y +L+ G+A D L ++ N Sbjct: 161 SNGDNDIVAMLLNAGADASAIDANGRTPVQVVCFYNHASTLHLLISKGSA-DFLKRSPNN 219 Query: 469 ---PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 PLH AA G ECV +LL A++ ++LDG TP ++A VV+ + Sbjct: 220 GWVPLHEAAMRGSLECVKVLLSFNASMYPRSLDGDTPRDLALQYENYNVVEFFD 273 Score = 52.0 bits (123), Expect = 2e-06 Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 2/96 (2%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + + G ALH +C G+ +LL AGA A+D N TP+ Y + L Sbjct: 144 NVNARSISGLTALHISCSNGDNDIVAMLLNAGADASAIDANGRTPVQVVCFYNHASTLHL 203 Query: 421 LLKHGAAVMLQNL--DGKTPIEVAKLNSQDEVVKLL 320 L+ G+A L+ +G P+ A + E VK+L Sbjct: 204 LISKGSADFLKRSPNNGWVPLHEAAMRGSLECVKVL 239
>ACBD6_BRARE (Q4V8X4) Acyl-CoA-binding domain-containing protein 6| Length = 300 Score = 56.6 bits (135), Expect = 6e-08 Identities = 30/87 (34%), Positives = 48/87 (55%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D EGR LH+AC G +LL+ A +++ D T LHYA+ E V+LLLK G Sbjct: 207 DEEGRALLHWACDRGHKDLVSLLLQNNADINSQDDEGQTALHYASACEFAEIVELLLKAG 266 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVK 326 A +++ +G P EV + ++ +++ Sbjct: 267 ADPSIKDQEGSLPEEVTESSAISSLLR 293 Score = 36.6 bits (83), Expect = 0.066 Identities = 20/60 (33%), Positives = 33/60 (55%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V+ D+ LH+A G K+ V LLL++ A + Q+ +G+T + A E+V+LL Sbjct: 203 VNTRDEEGRALLHWACDRGHKDLVSLLLQNNADINSQDDEGQTALHYASACEFAEIVELL 262 Score = 32.3 bits (72), Expect = 1.3 Identities = 17/50 (34%), Positives = 27/50 (54%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 L A+ + +D EG+ ALH+A + E+LL+AGA D+ + P Sbjct: 230 LQNNADINSQDDEGQTALHYASACEFAEIVELLLKAGADPSIKDQEGSLP 279
>ASZ1_CALMO (Q2QLB5) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 476 Score = 56.2 bits (134), Expect = 8e-08 Identities = 33/80 (41%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 156 YAARDGHTQVVALLVAGGAEVNTQDENGYTALTWAARQGHKSIVLKLLELGANKMLQTKD 215 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ LL Sbjct: 216 GKLPSEIAKRNKHHEIFNLL 235 Score = 38.1 bits (87), Expect = 0.023 Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G +VDA + TPL YAA E V +LL GA + D +T + Sbjct: 58 GDVSLVQELLDSGISVDATFRYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQTIL 116 Query: 364 EVA--KLNSQDEVVKLLEQDVFL*SKPSDP 281 A S+++++K +E L S+ +DP Sbjct: 117 ITACSAHGSEEQILKCVE---LLLSRNADP 143 Score = 38.1 bits (87), Expect = 0.023 Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 5/115 (4%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 + GD +++ LD G + D G L +A + +LL+ GA + +K+K T Sbjct: 56 TTGDVSLVQELLDSGISVDATFRYGWTPLMYAASVANAELVRVLLDRGANA-SFEKDKQT 114 Query: 469 PLHYA-AGYGRKE----CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L A + +G +E CV+LLL A + TPI A + +VV LL Sbjct: 115 ILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALL 169
>IKBE_HUMAN (O00221) NF-kappa-B inhibitor epsilon (NF-kappa-BIE)| (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE) Length = 361 Score = 56.2 bits (134), Expect = 8e-08 Identities = 36/89 (40%), Positives = 49/89 (55%), Gaps = 1/89 (1%) Frame = -3 Query: 616 LDGGANKD-EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 L GA+ D +E G+ ALH A E + LL+AGA VDA N TPLH AAG G Sbjct: 251 LRNGADIDVQEGSSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGL 310 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 L K GA +L+N++ +TP ++ + Sbjct: 311 MGISSTLCKAGADSLLRNVEDETPQDLTE 339
>V014_FOWPV (Q9J5I7) Putative ankyrin repeat protein FPV014| Length = 437 Score = 55.8 bits (133), Expect = 1e-07 Identities = 35/108 (32%), Positives = 56/108 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E K +D GA + + +H A G + LL GA D D+ + L Sbjct: 143 GNLEICKLLIDAGARINSRSMGSVYTIHHAIRSGNYELVVELLSRGALPDVEDELSFSSL 202 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+A G + V LL+HGA+V +Q+ G+TP+ +A S+ ++VK+L Sbjct: 203 HHAVMEGSADMVLTLLEHGASVDVQDFCGRTPLFLAANASELDIVKVL 250 Score = 44.3 bits (103), Expect = 3e-04 Identities = 37/110 (33%), Positives = 51/110 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E + + L GA D ED +LH A G LLE GA+VD D TPL Sbjct: 176 GNYELVVELLSRGALPDVEDELSFSSLHHAVMEGSADMVLTLLEHGASVDVQDFCGRTPL 235 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 AA + V +LL A + + TP+ V LNS D +++ +Q Sbjct: 236 FLAANASELDIVKVLLDFWADTSVSS-GRNTPLSVCDLNS-DTGIEIAKQ 283
>GABP3_MOUSE (P81069) GA-binding protein beta-2-1 chain (GABP-beta-2-1 subunit)| (GABPB2-1) Length = 414 Score = 55.8 bits (133), Expect = 1e-07 Identities = 38/98 (38%), Positives = 51/98 (52%), Gaps = 3/98 (3%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A YG AE+LL AG + DA K TPLH AA G V+LL++ GA V Sbjct: 38 GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHVHIVELLVRSGADV 97 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLLEQ---DVFL*SK 293 +++ T + A + VV+LL + DV+ SK Sbjct: 98 NAKDMLQMTALHWATEHHHRLVVELLIKYGADVYAFSK 135 Score = 54.7 bits (130), Expect = 2e-07 Identities = 30/101 (29%), Positives = 54/101 (53%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G ++D R LH A G + E+L+ +GA V+A D + T LH+A + + Sbjct: 58 LRAGVSRDARTKVDRTPLHMAAADGHVHIVELLVRSGADVNAKDMLQMTALHWATEHHHR 117 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 V+LL+K+GA V + K+ ++A + E++ +L++ Sbjct: 118 LVVELLIKYGADVYAFSKFDKSAFDIAMEKNNTEILVMLQE 158 Score = 34.7 bits (78), Expect = 0.25 Identities = 20/67 (29%), Positives = 33/67 (49%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 +L A A D +PLH AA YG ++LL+ G + + +TP+ +A + Sbjct: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGH 83 Query: 340 DEVVKLL 320 +V+LL Sbjct: 84 VHIVELL 90
>ASZ1_PONPY (Q2IBE3) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 55.5 bits (132), Expect = 1e-07 Identities = 33/80 (41%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ LL Sbjct: 215 GKMPSEIAKRNKHHEIFNLL 234 Score = 35.8 bits (81), Expect = 0.11 Identities = 25/88 (28%), Positives = 44/88 (50%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G +VD+ + TPL YAA E V +LL GA + K I Sbjct: 57 GDVSLVQELLDSGISVDSTFQYGWTPLMYAASVANAELVRVLLDRGANASFEK--DKQSI 114 Query: 364 EVAKLNSQDEVVKLLEQDVFL*SKPSDP 281 + +++ ++L+ L S+ +DP Sbjct: 115 LITACSARGSEEQILKCVELLLSRNADP 142
>ASZ1_PAPAN (Q8WMX7) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 55.5 bits (132), Expect = 1e-07 Identities = 33/80 (41%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ LL Sbjct: 215 GKMPSEIAKRNKHHEIFNLL 234 Score = 40.0 bits (92), Expect = 0.006 Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 5/115 (4%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 ++GD +++ LD G + D G L +A + +LL+ GA + +K+K T Sbjct: 55 TIGDVSLVQELLDSGISVDSTFQYGWTPLMYAASVANAELVRVLLDRGANA-SFEKDKQT 113 Query: 469 PLHYA-AGYGRKE----CVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L A + +G +E CV+LLL A + TPI A + +VV LL Sbjct: 114 ILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALL 168 Score = 36.6 bits (83), Expect = 0.066 Identities = 28/90 (31%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G +VD+ + TPL YAA E V +LL GA + D +T + Sbjct: 57 GDVSLVQELLDSGISVDSTFQYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQTIL 115 Query: 364 EVA--KLNSQDEVVKLLEQDVFL*SKPSDP 281 A S+++++K +E L S+ +DP Sbjct: 116 ITACSAHGSEEQILKCVE---LLLSRNADP 142
>ASZ1_PANTR (Q8WMX6) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 55.5 bits (132), Expect = 1e-07 Identities = 33/80 (41%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ LL Sbjct: 215 GKMPSEIAKRNKHHEIFNLL 234 Score = 36.2 bits (82), Expect = 0.087 Identities = 26/89 (29%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G +VD+ + TPL YAA E V +LL GA + I Sbjct: 57 GDVSLVQELLDSGISVDSTFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116 Query: 364 EVAKLN-SQDEVVKLLEQDVFL*SKPSDP 281 + S+++++K +E L S+ +DP Sbjct: 117 TACSAHGSEEQILKCVE---LLLSRNADP 142
>ASZ1_HUMAN (Q8WWH4) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 55.5 bits (132), Expect = 1e-07 Identities = 33/80 (41%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ LL Sbjct: 215 GKMPSEIAKRNKHHEIFNLL 234 Score = 35.4 bits (80), Expect = 0.15 Identities = 26/89 (29%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G +VD+ + TPL YAA E V +LL GA + I Sbjct: 57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILI 116 Query: 364 EVAKLN-SQDEVVKLLEQDVFL*SKPSDP 281 + S+++++K +E L S+ +DP Sbjct: 117 TACSAHGSEEQILKCVE---LLLSRNADP 142
>V245_FOWPV (Q9J4Z5) Putative ankyrin repeat protein FPV245| Length = 436 Score = 55.5 bits (132), Expect = 1e-07 Identities = 34/107 (31%), Positives = 54/107 (50%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 D E +K + GA+ + +D G +H A + ++LLE GA + D N+PLH Sbjct: 136 DLEVIKMLFEYGADVNIKDDNGCYPIHIATRSNSYEIIKLLLEKGAYANVKDNYGNSPLH 195 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA YG C+ L+L H + + +G TP+ A L ++ V L+ Sbjct: 196 NAAKYGDYACIKLVLDHTNNISNKCNNGVTPLHNAILYNRSAVELLI 242 Score = 50.4 bits (119), Expect = 4e-06 Identities = 30/105 (28%), Positives = 52/105 (49%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K LD G + ++ + + LH+A +L+ ++L E GA V+ D N P+H A Sbjct: 105 EMIKTILDSGVKVNTKNAKSKTFLHYAIKNNDLEVIKMLFEYGADVNIKDDNGCYPIHIA 164 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 E + LLL+ GA +++ G +P+ A +KL+ Sbjct: 165 TRSNSYEIIKLLLEKGAYANVKDNYGNSPLHNAAKYGDYACIKLV 209 Score = 43.9 bits (102), Expect = 4e-04 Identities = 35/138 (25%), Positives = 59/138 (42%), Gaps = 33/138 (23%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K L+ GA + +D G LH A YG+ C +++L+ + N TPLH A Sbjct: 171 EIIKLLLEKGAYANVKDNYGNSPLHNAAKYGDYACIKLVLDHTNNISNKCNNGVTPLHNA 230 Query: 454 AGYGRK--------------------------------ECVDLLLKHGAAVMLQNLDGKT 371 Y R + +D+LL + A + +++ +G+ Sbjct: 231 ILYNRSAVELLINNRSINDTDVDGYTPLHYALQPPCSIDIIDILLYNNADISIKDNNGRN 290 Query: 370 PIEVA-KLNSQDEVVKLL 320 PI+ A K ++D V+K L Sbjct: 291 PIDTAFKYINRDSVIKEL 308 Score = 33.1 bits (74), Expect = 0.73 Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 1/76 (1%) Frame = -3 Query: 544 GELKCAEILLE-AGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTP 368 G++ E L++ G ++ + TPL A G + V+L +KHGA V N P Sbjct: 12 GDISLVEKLIKNKGNCINISVEETTTPLIDAIRTGNAKIVELFIKHGAQVNHVNTKIPNP 71 Query: 367 IEVAKLNSQDEVVKLL 320 + A ++VKLL Sbjct: 72 LLTAIKIGSHDIVKLL 87
>Y196_THEAC (Q9HLN1) Hypothetical ANK-repeat protein Ta0196| Length = 208 Score = 55.5 bits (132), Expect = 1e-07 Identities = 29/92 (31%), Positives = 50/92 (54%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D+ D+EG AL +A ++ A+ L+ ++D D NTP+ +A +G + V LL+ Sbjct: 77 DDRDIEGNTALMWAVRNNRMESAKSLIALKCSIDIPDSAGNTPICWAVIFGYTDMVKLLI 136 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 GA + + N +G TP +A + E +K+L Sbjct: 137 SSGANINISNDEGDTPAILASKYGRSECLKML 168 Score = 42.7 bits (99), Expect = 0.001 Identities = 22/92 (23%), Positives = 49/92 (53%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D G + +A +G ++L+ +GA ++ + +TP A+ YGR EC+ +L+ Sbjct: 110 DIPDSAGNTPICWAVIFGYTDMVKLLISSGANINISNDEGDTPAILASKYGRSECLKMLI 169 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + G + +N + + + A+ + E++++L Sbjct: 170 EAGCDLNAKNHNAQNVWKAAEAFGRKEILEVL 201 Score = 42.0 bits (97), Expect = 0.002 Identities = 23/75 (30%), Positives = 39/75 (52%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + +K + GAN + + EG A YG +C ++L+EAG ++A + N Sbjct: 127 GYTDMVKLLISSGANINISNDEGDTPAILASKYGRSECLKMLIEAGCDLNAKNHNAQNVW 186 Query: 463 HYAAGYGRKECVDLL 419 A +GRKE +++L Sbjct: 187 KAAEAFGRKEILEVL 201
>ASZ1_MOUSE (Q8VD46) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 55.1 bits (131), Expect = 2e-07 Identities = 32/80 (40%), Positives = 44/80 (55%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+A D+N T L +AA G K + LL+ GA MLQ D Sbjct: 155 YAARDGHTQVVALLVAHGAEVNAQDENGYTALTWAARQGHKNVILKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 G+TP E+AK N E+ L Sbjct: 215 GRTPSEIAKRNKHLEIFNFL 234 Score = 43.5 bits (101), Expect = 5e-04 Identities = 39/149 (26%), Positives = 57/149 (38%), Gaps = 38/149 (25%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGE----------------------- 539 + GD +K+ LD G N D G L +A Sbjct: 55 TTGDISLVKELLDSGINVDSSFRYGWTPLMYAASVANAELVRFLLDRGANASFDKDKLTI 114 Query: 538 --------------LKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 LKC E+LL A + + TP+ YAA G + V LL+ HGA Sbjct: 115 LISACSARGSEEQVLKCVELLLSRNADPNTACRRLMTPIMYAARDGHTQVVALLVAHGAE 174 Query: 400 VMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 V Q+ +G T + A+ ++ ++KLLE Sbjct: 175 VNAQDENGYTALTWAARQGHKNVILKLLE 203 Score = 33.9 bits (76), Expect = 0.43 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 3/91 (3%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G VD+ + TPL YAA E V LL GA K I Sbjct: 57 GDISLVKELLDSGINVDSSFRYGWTPLMYAASVANAELVRFLLDRGANASFDK--DKLTI 114 Query: 364 EVAKLN---SQDEVVKLLEQDVFL*SKPSDP 281 ++ + S+++V+K +E L S+ +DP Sbjct: 115 LISACSARGSEEQVLKCVE---LLLSRNADP 142
>ASB9_HUMAN (Q96DX5) Ankyrin repeat and SOCS box protein 9 (ASB-9)| Length = 294 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/82 (41%), Positives = 47/82 (57%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH AC G L C +ILL+ GA V+ + + +TPL A G +CV+LLL+HGA+V ++ Sbjct: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 D +PI A E V L Sbjct: 133 -DLASPIHEAARRGHVECVNSL 153 Score = 48.5 bits (114), Expect = 2e-05 Identities = 30/95 (31%), Positives = 47/95 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + + G N D + L+ AC + C + LLE+GA V+ K +++PL Sbjct: 145 GHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPL 203 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEV 359 H A +E LL+ GA +N +GK P+E+ Sbjct: 204 HAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/84 (34%), Positives = 41/84 (48%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 +H A +G L+ G AV+ + + +PLH A G CV +LLKHGA V Sbjct: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99 Query: 385 LDGKTPIEVAKLNSQDEVVKLLEQ 314 D TP+ A ++ + V LL Q Sbjct: 100 ADWHTPLFNACVSGSWDCVNLLLQ 123 Score = 37.0 bits (84), Expect = 0.051 Identities = 26/97 (26%), Positives = 44/97 (45%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + + E D+ +H A G ++C L+ G +D + TPL+ A ++ C Sbjct: 125 GASVQPESDLAS--PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRAC 182 Query: 430 VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V LL+ GA V Q +P+ + +E+ LL Sbjct: 183 VKKLLESGADVN-QGKGQDSPLHAVARTASEELACLL 218
>ASB5_HUMAN (Q8WWX0) Ankyrin repeat and SOCS box protein 5 (ASB-5)| Length = 329 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/92 (36%), Positives = 48/92 (52%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + ++G L AC G CAE+LLE GA L+ +P H AA G Sbjct: 123 LEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHH 181 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 EC+D+L+ G V + TP+ VA ++ Q Sbjct: 182 ECLDILISWGIDVDQEIPHLGTPLYVACMSQQ 213 Score = 52.8 bits (125), Expect = 9e-07 Identities = 32/88 (36%), Positives = 45/88 (51%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G L+ L G N + ++ LH AC + CA LLEAGA V+A+ + T Sbjct: 79 SQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVT 138 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQN 386 PL A G C +LLL++GA L++ Sbjct: 139 PLFNACSQGSPSCAELLLEYGAKAQLES 166 Score = 48.9 bits (115), Expect = 1e-05 Identities = 39/109 (35%), Positives = 53/109 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E L + G + D+E L+ AC + C LL AGA V K +T Sbjct: 177 SKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDT 235 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 PLH AA E V+LLL+ GA + +N + PI+VA +S E + L Sbjct: 236 PLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284 Score = 41.2 bits (95), Expect = 0.003 Identities = 27/81 (33%), Positives = 35/81 (43%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + R LH A G L LL G V+A+ + TPLH A C Sbjct: 60 GVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACA 119 Query: 427 DLLLKHGAAVMLQNLDGKTPI 365 LL+ GA V +DG TP+ Sbjct: 120 RTLLEAGANVNAITIDGVTPL 140 Score = 37.4 bits (85), Expect = 0.039 Identities = 27/81 (33%), Positives = 37/81 (45%) Frame = -3 Query: 562 HFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL 383 H A G +C +IL+ G VD + TPL+ A + C+ LL GA V + Sbjct: 173 HEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGK 231 Query: 382 DGKTPIEVAKLNSQDEVVKLL 320 TP+ A S E+V LL Sbjct: 232 YWDTPLHAAAQQSSTEIVNLL 252
>ASB11_HUMAN (Q8WXH4) Ankyrin repeat and SOCS box protein 11 (ASB-11)| Length = 323 Score = 55.1 bits (131), Expect = 2e-07 Identities = 37/110 (33%), Positives = 55/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L N D E + L+ AC Y + C + LLE GA+VD + +TPL Sbjct: 174 GHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPL 232 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H AA E + LL +GA + +N GK+ +++A S E LL + Sbjct: 233 HAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 282 Score = 49.7 bits (117), Expect = 8e-06 Identities = 34/103 (33%), Positives = 52/103 (50%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 LK + G N + + +LH AC G + CA+ LLE GA V+ + + TPL A Sbjct: 81 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACC 140 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G CV++LL+ GA L+ + +PI A E +++L Sbjct: 141 SGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEIL 182 Score = 47.0 bits (110), Expect = 5e-05 Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G A + L+ GA K + +V +H A G +C EILL +D TPL Sbjct: 142 GSAACVNVLLEFGA-KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPL 200 Query: 463 HYAAGYGRKECVDLLLKHGAAV-MLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A Y R +CV LL+ GA+V Q LD TP+ A S EV+ LL Sbjct: 201 YVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIHLL 247
>AKR1_CRYNE (Q5KP49) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 776 Score = 54.7 bits (130), Expect = 2e-07 Identities = 29/81 (35%), Positives = 49/81 (60%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 DE+D +G AL +A G+ ++L+ GA+V++ D TPLH+AA G K + L+ Sbjct: 198 DEKDTDGHTALMWAAYQGDALSVDLLIRHGASVNSTDNAGMTPLHWAAVKGNKVSIMHLV 257 Query: 415 KHGAAVMLQNLDGKTPIEVAK 353 + GA++ + GKTP ++A+ Sbjct: 258 EAGASLDAKEEAGKTPRDMAE 278 Score = 43.5 bits (101), Expect = 5e-04 Identities = 31/106 (29%), Positives = 52/106 (49%), Gaps = 1/106 (0%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + D +G LH + +L A+D D + +T L +AA G V Sbjct: 161 GADPNIHDSQGFNTLHLITHSSAVMPLLYMLHQPVAIDEKDTDGHTALMWAAYQGDALSV 220 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKL-NSQDEVVKLLEQDVFL*SK 293 DLL++HGA+V + G TP+ A + ++ ++ L+E L +K Sbjct: 221 DLLIRHGASVNSTDNAGMTPLHWAAVKGNKVSIMHLVEAGASLDAK 266 Score = 38.1 bits (87), Expect = 0.023 Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 2/108 (1%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDAL-DKNKNTPLHYAAGYGRKECVD 425 N D + LH+A + +L+++GA +DA+ + K TPL +AA G V Sbjct: 96 NLSARDAQDVTPLHWAAINAHMGTCRLLIDSGADIDAIGGELKATPLQWAARNGHLYVVH 155 Query: 424 LLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLEQDVFL*SKPSD 284 LL+ GA + + G + + ++ ++ +L Q V + K +D Sbjct: 156 LLISRGADPNIHDSQGFNTLHLITHSSAVMPLLYMLHQPVAIDEKDTD 203 Score = 33.1 bits (74), Expect = 0.73 Identities = 20/59 (33%), Positives = 30/59 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GDA + + GA+ + D G LH+A G L+EAGA++DA ++ TP Sbjct: 215 GDALSVDLLIRHGASVNSTDNAGMTPLHWAAVKGNKVSIMHLVEAGASLDAKEEAGKTP 273
>ASB2_BOVIN (Q3SX45) Ankyrin repeat and SOCS box protein 2 (ASB-2)| Length = 633 Score = 54.7 bits (130), Expect = 2e-07 Identities = 36/110 (32%), Positives = 51/110 (46%), Gaps = 1/110 (0%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEA-GAAVDALDKNKNTPL 464 D E L + G N E + EG LH A YG+L C + L A A +D + T L Sbjct: 115 DEEALTAMIKAGKNLSEPNKEGWLPLHEAAYYGQLNCLKALHRAYPAVIDQRTLQEETAL 174 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 + A G +C+ LL+ GA + N +TP+ A E V++L Q Sbjct: 175 YLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQ 224 Score = 49.7 bits (117), Expect = 8e-06 Identities = 29/107 (27%), Positives = 50/107 (46%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 D E ++ + GGA + ++ G L A G+L+ L + GA ++ + + L+ Sbjct: 248 DLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDSASALY 307 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A G +E V+ LL GA N DG P+ +A +V++L Sbjct: 308 EACKNGHEEVVEFLLSQGADANKTNKDGMLPLHIASKKGNYRIVQML 354 Score = 49.3 bits (116), Expect = 1e-05 Identities = 31/86 (36%), Positives = 45/86 (52%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G ALH + +L+ EIL+ GA V+A + TPL AA G+ E + L K+GA + Sbjct: 236 GWTALHESVARNDLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADI 295 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 Q D + + A N +EVV+ L Sbjct: 296 NTQASDSASALYEACKNGHEEVVEFL 321 Score = 43.1 bits (100), Expect = 7e-04 Identities = 26/92 (28%), Positives = 48/92 (52%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D+ ++ AL+ A G + C + LL+AGA D +K++ TPL+ A E V +L+ Sbjct: 164 DQRTLQEETALYLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILV 223 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 ++ A + G T + + + EV+++L Sbjct: 224 QYKADTNHRCNRGWTALHESVARNDLEVMEIL 255 Score = 30.0 bits (66), Expect = 6.2 Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 4/65 (6%) Frame = -3 Query: 580 EGRR--ALHFACGYGELKCAEILLEAGAAVDALDKNKNT--PLHYAAGYGRKECVDLLLK 413 E RR AL+FA + E+LL AGA D N++ PL A +G + LLL Sbjct: 406 EDRRSSALYFAVVNNNVYATELLLLAGA-----DPNRDVINPLLVAIRHGCLRTMQLLLD 460 Query: 412 HGAAV 398 HGA + Sbjct: 461 HGANI 465
>PP16B_MOUSE (Q8VHQ3) Protein phosphatase 1 regulatory inhibitor subunit 16B| (TGF-beta-inhibited membrane-associated protein) (CAAX box protein TIMAP) Length = 568 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/97 (35%), Positives = 53/97 (54%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + D D +G LH A G L+ AE+LL+ G VD D + PLH AA +G+ Sbjct: 219 GQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMA 278 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 +LL+ HGA++ + + PI++ + ++ V LLE Sbjct: 279 ELLVSHGASLSARTSMDEMPIDLCE--EEEFKVLLLE 313 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/96 (33%), Positives = 50/96 (52%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 DAE ++ L + D + +G ALH C + ++LL GA V+A D TPLH Sbjct: 80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLH 139 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 AA G V +L+++GA ++ N DG P ++ + Sbjct: 140 AAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175 Score = 38.5 bits (88), Expect = 0.017 Identities = 22/67 (32%), Positives = 33/67 (49%) Frame = -3 Query: 520 LLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 ++ AG +D +D T LH A G +LLL HG V +++ DG P+ A Q Sbjct: 215 MIAAGQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQ 274 Query: 340 DEVVKLL 320 + +LL Sbjct: 275 MPMAELL 281 Score = 31.2 bits (69), Expect = 2.8 Identities = 26/98 (26%), Positives = 42/98 (42%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + E AL A + + L+ + D +++ T LH +E V Sbjct: 58 GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLL HGA V ++ + TP+ A +VK+L Q Sbjct: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQ 155
>ACBD6_HUMAN (Q9BR61) Acyl-CoA-binding domain-containing protein 6| Length = 282 Score = 54.7 bits (130), Expect = 2e-07 Identities = 30/77 (38%), Positives = 43/77 (55%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 +D EGR LH+AC G + +LL+ A ++ D T LHYA+ + V+LLL+ Sbjct: 188 KDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQS 247 Query: 409 GAAVMLQNLDGKTPIEV 359 GA L++ DG P EV Sbjct: 248 GADPTLRDQDGCLPEEV 264 Score = 39.3 bits (90), Expect = 0.010 Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 5/103 (4%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V+ D+ LH+A G KE V +LL+H A + Q+ +G+T + A ++V+LL Sbjct: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELL 244 Query: 319 EQDVFL*SKPSDPVLID-----PKTLPCFWSLSGVMSWHGVGR 206 Q +DP L D P+ + ++S V+ H G+ Sbjct: 245 LQ------SGADPTLRDQDGCLPEEVTGCKTVSLVLQRHTTGK 281
>ASB5_MOUSE (Q9D1A4) Ankyrin repeat and SOCS box protein 5 (ASB-5)| Length = 329 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/92 (36%), Positives = 47/92 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + ++G L AC G CAE+LLE GA L+ +P H AA G Sbjct: 123 LEAGANANAITIDGVTPLFNACSQGSASCAELLLEYGAKAQ-LESCFPSPTHEAASKGHH 181 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 EC+D+L+ G V TP+ VA ++ Q Sbjct: 182 ECLDILIAWGIDVDQDIPHLGTPLYVACMSQQ 213 Score = 52.0 bits (123), Expect = 2e-06 Identities = 31/88 (35%), Positives = 44/88 (50%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G L+ L G N + ++ LH AC + CA LLEAGA +A+ + T Sbjct: 79 SQGRLLALRTLLSQGYNVNAVTIDHVTPLHEACLGDHVACARTLLEAGANANAITIDGVT 138 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQN 386 PL A G C +LLL++GA L++ Sbjct: 139 PLFNACSQGSASCAELLLEYGAKAQLES 166 Score = 47.4 bits (111), Expect = 4e-05 Identities = 38/109 (34%), Positives = 53/109 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E L + G + D++ L+ AC + C LL AGA V K +T Sbjct: 177 SKGHHECLDILIAWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVHK-GKYWDT 235 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 PLH AA E V+LLL+ GA + +N D P+++A NS E + L Sbjct: 236 PLHAAAQQPSTEIVNLLLEFGADINAKNTDLLRPVDLATSNSAVERILL 284 Score = 39.7 bits (91), Expect = 0.008 Identities = 26/81 (32%), Positives = 35/81 (43%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G ++ + R LH A G L LL G V+A+ + TPLH A C Sbjct: 60 GVSQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTIDHVTPLHEACLGDHVACA 119 Query: 427 DLLLKHGAAVMLQNLDGKTPI 365 LL+ GA +DG TP+ Sbjct: 120 RTLLEAGANANAITIDGVTPL 140
>ASZ1_HORSE (Q2QLA4) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 54.3 bits (129), Expect = 3e-07 Identities = 33/80 (41%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GKTP E+AK N E+ L Sbjct: 215 GKTPSEIAKRNKHLEIFNFL 234 Score = 50.1 bits (118), Expect = 6e-06 Identities = 42/117 (35%), Positives = 61/117 (52%), Gaps = 6/117 (5%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFAC---GYGE--LKCAEILLEAGAAVDALD 485 SV + + ++ LD GA K D + + L AC G E LKC E+LL A + Sbjct: 88 SVSNVDLVRVLLDRGA-KASFDKDKQTILITACSARGSEEQILKCVELLLSRNADPNVAC 146 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 + TP+ YAA G + V LL+ HGA V Q+ +G T + A+ ++ V+KLLE Sbjct: 147 RRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLE 203 Score = 37.0 bits (84), Expect = 0.051 Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 5/117 (4%) Frame = -3 Query: 616 LDGGANKDEEDV---EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 LD A K +E + E A G++ E LL++G +VD+ + TPL YAA Sbjct: 30 LDRAAQKLKEPLPIEEKNETFKRALTAGDVALVEELLDSGISVDSSFRYGWTPLMYAASV 89 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVA--KLNSQDEVVKLLEQDVFL*SKPSDP 281 + V +LL GA D +T + A S+++++K +E L S+ +DP Sbjct: 90 SNVDLVRVLLDRGAKASFDK-DKQTILITACSARGSEEQILKCVE---LLLSRNADP 142
>ASB2_HUMAN (Q96Q27) Ankyrin repeat and SOCS box protein 2 (ASB-2)| Length = 587 Score = 54.3 bits (129), Expect = 3e-07 Identities = 36/111 (32%), Positives = 53/111 (47%), Gaps = 1/111 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEA-GAAVDALDKNKNTP 467 GD E LK + G N E + EG LH A YG++ C ++L A +D + T Sbjct: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETA 127 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 ++ A G +C+ LL+ GA + N +TP+ A E VK+L Q Sbjct: 128 VYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178 Score = 50.8 bits (120), Expect = 3e-06 Identities = 33/107 (30%), Positives = 54/107 (50%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE +K + A+ + G ALH + +L+ +IL+ GA V++ + TPL Sbjct: 169 NAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G+ E + L K+GA + Q D + + A N +EVV+ L Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFL 275 Score = 47.0 bits (110), Expect = 5e-05 Identities = 29/110 (26%), Positives = 50/110 (45%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S D E ++ + GGA + ++ G L A G+L+ L + GA ++ + + Sbjct: 199 SRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNAS 258 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L+ A +E V+ LL GA N DG P+ +A +V++L Sbjct: 259 ALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML 308 Score = 30.0 bits (66), Expect = 6.2 Identities = 24/65 (36%), Positives = 34/65 (52%), Gaps = 4/65 (6%) Frame = -3 Query: 580 EGRR--ALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYGRKECVDLLLK 413 E RR AL+FA + E+LL+ GA D N++ +PL A +G + LLL Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGA-----DPNRDVISPLLVAIRHGCLRTMQLLLD 414 Query: 412 HGAAV 398 HGA + Sbjct: 415 HGANI 419
>GORK_ARATH (Q94A76) Potassium channel GORK (Guard cell outward rectifying K(+)| channel) (AtGORK) Length = 820 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/75 (40%), Positives = 44/75 (58%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD++ LK+ L G N + ED + R LH A G A++L+EAGA+V + D+ N+PL Sbjct: 639 GDSDFLKRLLSSGMNPNSEDYDHRTPLHVAASEGLFLMAKMLVEAGASVISKDRWGNSPL 698 Query: 463 HYAAGYGRKECVDLL 419 A G K+ + LL Sbjct: 699 DEARLCGNKKLIKLL 713 Score = 50.4 bits (119), Expect = 4e-06 Identities = 33/100 (33%), Positives = 50/100 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD LK + GA+ ++ D +GR LH A G L++ G V+ DK +TPL Sbjct: 542 GDFYQLKSLIRSGADPNKTDYDGRSPLHLAACRGYEDITLFLIQEGVDVNLKDKFGHTPL 601 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 A G++ + LL+K GA+ L++ VAK +S Sbjct: 602 FEAVKAGQEGVIGLLVKEGASFNLEDSGNFLCTTVAKGDS 641 Score = 38.1 bits (87), Expect = 0.023 Identities = 25/94 (26%), Positives = 48/94 (51%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 +++ E ++ A G+ + L+ +GA + D + +PLH AA G ++ L++ Sbjct: 526 KQEAELALKVNSAAFQGDFYQLKSLIRSGADPNKTDYDGRSPLHLAACRGYEDITLFLIQ 585 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 G V L++ G TP+ A Q+ V+ LL ++ Sbjct: 586 EGVDVNLKDKFGHTPLFEAVKAGQEGVIGLLVKE 619
>MIB2_MOUSE (Q8R516) Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb| homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike) Length = 973 Score = 54.3 bits (129), Expect = 3e-07 Identities = 32/97 (32%), Positives = 47/97 (48%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E ++ L A+ D D EG LH+ + + +LL AG AVDA + ++T Sbjct: 491 LGQVELVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTA 550 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH A G E V +L + G V L + TP+ A Sbjct: 551 LHVAVQRGFLEVVKILCERGCDVNLPDAHADTPLHSA 587 Score = 53.1 bits (126), Expect = 7e-07 Identities = 33/87 (37%), Positives = 46/87 (52%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +GR AL A G+++ +LL+A A++D D NT LHY A + E +LL G A Sbjct: 480 QGRTALQVAAYLGQVELVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCA 539 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V +N T + VA EVVK+L Sbjct: 540 VDARNGTRSTALHVAVQRGFLEVVKIL 566 Score = 40.4 bits (93), Expect = 0.005 Identities = 33/98 (33%), Positives = 44/98 (44%), Gaps = 3/98 (3%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L G D + ALH A G L+ +IL E G V+ D + +TPLH A Sbjct: 528 EATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCERGCDVNLPDAHADTPLHSA 587 Query: 454 --AGYGRKECVDLLLK-HGAAVMLQNLDGKTPIEVAKL 350 AG G V++L + G V N G T + A L Sbjct: 588 ISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASL 625
>ASB11_PONPY (Q5RFS1) Ankyrin repeat and SOCS box protein 11 (ASB-11)| Length = 323 Score = 54.3 bits (129), Expect = 3e-07 Identities = 37/108 (34%), Positives = 54/108 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L N D E + L+ AC Y + C + LLE GA+VD + +TPL Sbjct: 174 GHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPL 232 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA E + LL +GA + +N GK+ +++A S E LL Sbjct: 233 HAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 280 Score = 48.1 bits (113), Expect = 2e-05 Identities = 33/103 (32%), Positives = 51/103 (49%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 LK + G N + + +LH AC G + CA+ LLE GA V+ + + TPL A Sbjct: 81 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACC 140 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 G CV++LL+ GA + + +PI A E +++L Sbjct: 141 SGSAACVNVLLEFGAKAQFE-VHLASPIHEAVKRGHRECMEIL 182 Score = 47.0 bits (110), Expect = 5e-05 Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G A + L+ GA K + +V +H A G +C EILL +D TPL Sbjct: 142 GSAACVNVLLEFGA-KAQFEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPL 200 Query: 463 HYAAGYGRKECVDLLLKHGAAV-MLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A Y R +CV LL+ GA+V Q LD TP+ A S EV+ LL Sbjct: 201 YVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIHLL 247
>ANR18_HUMAN (Q8IVF6) Ankyrin repeat domain-containing protein 18A| Length = 992 Score = 53.9 bits (128), Expect = 4e-07 Identities = 35/101 (34%), Positives = 55/101 (54%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + +D+ G ALH+A AE LL A ++AL+K NTPL +A R+ Sbjct: 121 LECGANPNIKDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ 180 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 V+ LLK+ A + + +T + +A ++ +V LL Q Sbjct: 181 HMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQ 221 Score = 48.5 bits (114), Expect = 2e-05 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 GDA +++ L + D D + R LH AC +G ++ +LL +D D+ TP Sbjct: 45 GDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTP 104 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L A + C +LL+ GA ++++ G T + A N + + L Sbjct: 105 LMKAVHSQEEACAIVLLECGANPNIKDIYGNTALHYAVYNKGTSLAERL 153 Score = 35.8 bits (81), Expect = 0.11 Identities = 26/90 (28%), Positives = 40/90 (44%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 ++ L AN + + EG L FA E LL+ A + A+D K T L A + Sbjct: 151 ERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQH 210 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 V LLL+ + Q++ G+T + A Sbjct: 211 NLSSIVTLLLQQNIRISSQDMFGQTAEDYA 240
>AKT5_ARATH (Q9SCX5) Probable potassium channel AKT5| Length = 880 Score = 53.9 bits (128), Expect = 4e-07 Identities = 31/86 (36%), Positives = 47/86 (54%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 +L FA G+ LL+ G+ + DKN T LH AA G + CV LLL+HGA ++ Sbjct: 545 SLCFAAARGDDLLLHQLLKRGSNPNETDKNGRTALHIAASKGSQYCVVLLLEHGADPNIR 604 Query: 388 NLDGKTPIEVAKLNSQDEVVKLLEQD 311 + +G P+ A + +E KLL ++ Sbjct: 605 DSEGSVPLWEAIIGRHEENAKLLSEN 630 Score = 48.9 bits (115), Expect = 1e-05 Identities = 35/108 (32%), Positives = 52/108 (48%), Gaps = 2/108 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD L + L G+N +E D GR ALH A G C +LLE GA + D + PL Sbjct: 553 GDDLLLHQLLKRGSNPNETDKNGRTALHIAASKGSQYCVVLLLEHGADPNIRDSEGSVPL 612 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK--LNSQDEVVK 326 A +E LL ++GA + + + + V + LN+ ++VK Sbjct: 613 WEAIIGRHEENAKLLSENGATLSFDTVGYFSCLAVGQNNLNALKDIVK 660 Score = 33.1 bits (74), Expect = 0.73 Identities = 19/48 (39%), Positives = 24/48 (50%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALD 485 LK + G + DV G ALH A G L+ + LLE GA +D D Sbjct: 655 LKDIVKYGGDISLSDVNGTTALHRAVSEGNLEIVQFLLEKGADMDKPD 702
>ASZ1_BOVIN (Q8WMX8) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 53.5 bits (127), Expect = 5e-07 Identities = 32/80 (40%), Positives = 43/80 (53%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA M+Q D Sbjct: 155 YAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMIQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GKTP E+AK N E+ L Sbjct: 215 GKTPSEIAKRNKHLEIFNFL 234 Score = 52.0 bits (123), Expect = 2e-06 Identities = 43/117 (36%), Positives = 61/117 (52%), Gaps = 6/117 (5%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFAC---GYGE--LKCAEILLEAGAAVDALD 485 SV + E ++ LD GAN D + + L AC G E LKC E+LL A + Sbjct: 88 SVSNVELVRVLLDRGANASF-DKDKQTVLITACSARGSEEKILKCIELLLSRNADPNVAC 146 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 + TP+ YAA G + V LL+ HGA V Q+ +G T + A+ ++ V+KLLE Sbjct: 147 RRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLE 203
>V244_FOWPV (Q9J4Z6) Putative ankyrin repeat protein FPV244| Length = 668 Score = 53.5 bits (127), Expect = 5e-07 Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 3/106 (2%) Frame = -3 Query: 628 LKKALDGGA---NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHY 458 LK+ + G NK + +E + + EL AE+LL+ G V+A D TP+HY Sbjct: 125 LKEGISGNEISYNKINKSIEYMKLIKERIQQDELLIAEMLLKKGIDVNAKDVYCRTPIHY 184 Query: 457 AAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G + V+LLL +GA V + LD + +E A + + +K + Sbjct: 185 AAERGNTKMVNLLLSYGADVNIITLDDLSVLEYAVDSKNIDTIKAI 230 Score = 47.8 bits (112), Expect = 3e-05 Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 1/98 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAA- 452 +K +D +N ++ D+ +A+ +L+ + +L ++G +V+++D KNTPLHYA Sbjct: 227 IKAIIDNRSNINKNDLSLLKAIRNT----DLETSLLLYDSGFSVNSIDVYKNTPLHYAVQ 282 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQD 338 V LL+ G V +N+ G+TP+ + N D Sbjct: 283 APSLSRLVPKLLERGIDVNAKNIKGETPLYLMAKNGYD 320 Score = 45.4 bits (106), Expect = 1e-04 Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 2/101 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAA-GYGR 440 L+ GAN + D + +H+A + LL+ GA ++AL + T LH+A G Sbjct: 362 LELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTVLHFALYGTNP 421 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQDEVVKLL 320 V L+ GA V +N TP+ A K N + EV+K+L Sbjct: 422 YMSVKTLIDRGANVNSKNKYLSTPLHYACKKNCKPEVIKML 462 Score = 38.1 bits (87), Expect = 0.023 Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 1/82 (1%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEI-LLEAGAAVDALDKNKNTPL 464 D E ++ + GA+ + D LH A K I LLE GA V+A D TP+ Sbjct: 320 DTENIRTLIMRGADVNAADSLYITPLHQASTLDRYKDTVITLLELGANVNARDYCDKTPI 379 Query: 463 HYAAGYGRKECVDLLLKHGAAV 398 HYAA ++ LL +GA + Sbjct: 380 HYAAVRNNVVIINTLLDYGADI 401 Score = 33.1 bits (74), Expect = 0.73 Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 1/76 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYG-ELKCAEILLEAGAAVDALDKNKNTPLHYAA 452 +K +D GAN + ++ LH+AC + + ++LL+ GA V+A++ PL A Sbjct: 425 VKTLIDRGANVNSKNKYLSTPLHYACKKNCKPEVIKMLLDNGADVNAINIRNQYPLLIAL 484 Query: 451 GYGRKECVDLLLKHGA 404 Y V++LL +GA Sbjct: 485 EY--HGIVNILLHYGA 498
>V218_FOWPV (Q9J517) Putative ankyrin repeat protein FPV218| Length = 461 Score = 53.5 bits (127), Expect = 5e-07 Identities = 33/96 (34%), Positives = 51/96 (53%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN + +D +G LH A A+ILLE GA V+ D PLH G E V Sbjct: 144 GANVNVQDSKGLSPLHHAVSKKTTLTAKILLENGARVNIRDSLGRLPLH--LGANTYEMV 201 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LL+ +G+ + +++++G TP+ A S + ++LL Sbjct: 202 KLLIDYGSPIDIKDVNGSTPLHYAIWKSSLDTIRLL 237 Score = 53.1 bits (126), Expect = 7e-07 Identities = 31/92 (33%), Positives = 53/92 (57%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K +D G+ D +DV G LH+A L +L+ + ++ALD N N+PLHY Sbjct: 199 EMVKLLIDYGSPIDIKDVNGSTPLHYAIWKSSLDTIRLLVNV-STINALDNNCNSPLHYI 257 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEV 359 + V+LLL+ GA + ++++ G TP+++ Sbjct: 258 ILSETEILVELLLR-GADITIKDICGNTPLDI 288 Score = 43.5 bits (101), Expect = 5e-04 Identities = 30/102 (29%), Positives = 50/102 (49%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K L+ GA + D GR LH E+ ++L++ G+ +D D N +TPLHYA Sbjct: 171 KILLENGARVNIRDSLGRLPLHLGANTYEM--VKLLIDYGSPIDIKDVNGSTPLHYAIWK 228 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + LL+ L N + +P+ L+ + +V+LL Sbjct: 229 SSLDTIRLLVNVSTINALDN-NCNSPLHYIILSETEILVELL 269 Score = 40.0 bits (92), Expect = 0.006 Identities = 27/89 (30%), Positives = 45/89 (50%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D E R LH+A ++ L+ GA V+ D +PLH+A +LL++G Sbjct: 118 DRESRSFLHYAAKNDDVDTVISLILHGANVNVQDSKGLSPLHHAVSKKTTLTAKILLENG 177 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A V +++ G+ P+ + + E+VKLL Sbjct: 178 ARVNIRDSLGRLPLHLGA--NTYEMVKLL 204 Score = 36.2 bits (82), Expect = 0.087 Identities = 22/76 (28%), Positives = 36/76 (47%) Frame = -3 Query: 547 YGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTP 368 Y ++L+ G V+ +D+ + LHYAA + V L+ HGA V +Q+ G +P Sbjct: 98 YVSFPIIKVLVYHGIDVNVIDRESRSFLHYAAKNDDVDTVISLILHGANVNVQDSKGLSP 157 Query: 367 IEVAKLNSQDEVVKLL 320 + A K+L Sbjct: 158 LHHAVSKKTTLTAKIL 173
>AKT6_ARATH (Q8GXE6) Potassium channel AKT6 (Shaker pollen inward rectifier| K(+) channel) (Potassium channel SPIK) Length = 888 Score = 53.5 bits (127), Expect = 5e-07 Identities = 30/86 (34%), Positives = 47/86 (54%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 +L FA G+ LL G++ + +DK+ T LH AA G CV LLL+HGA ++ Sbjct: 547 SLCFAAARGDDLLLHQLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEHGADPNIR 606 Query: 388 NLDGKTPIEVAKLNSQDEVVKLLEQD 311 + +G P+ A + E+ KLL ++ Sbjct: 607 DSEGNVPLWEAIIGRHREIAKLLAEN 632 Score = 51.2 bits (121), Expect = 3e-06 Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 2/108 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 GD L + L G++ +E D +GR ALH A G C +LLE GA + D N PL Sbjct: 555 GDDLLLHQLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEHGADPNIRDSEGNVPL 614 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK--LNSQDEVVK 326 A +E LL ++GA + L ++ + + V K L++ +++K Sbjct: 615 WEAIIGRHREIAKLLAENGAKLSLDSVSYFSGLAVEKNCLDALKDIIK 662
>MIB2_HUMAN (Q96AX9) Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb| homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N) Length = 1013 Score = 53.5 bits (127), Expect = 5e-07 Identities = 32/97 (32%), Positives = 46/97 (47%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E ++ L A D D EG ALH+A + + +LL AG DA++ ++T Sbjct: 533 LGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTA 592 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 LH A G E V L + G V L + TP+ A Sbjct: 593 LHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA 629 Score = 48.5 bits (114), Expect = 2e-05 Identities = 32/87 (36%), Positives = 42/87 (48%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +GR AL A G+++ +LL+A A VD D NT LHYAA + E +LL G Sbjct: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCR 581 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 N T + VA EVV+ L Sbjct: 582 ADAINSTQSTALHVAVQRGFLEVVRAL 608 Score = 36.2 bits (82), Expect = 0.087 Identities = 29/98 (29%), Positives = 40/98 (40%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E + L G D + ALH A G L+ L E G V+ D + +TPLH A Sbjct: 570 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA 629 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 G GA+ +++ L I+V NSQ Sbjct: 630 ISAGT----------GASGIVEVLTEVPNIDVTATNSQ 657
>ASB2_MOUSE (Q8K0L0) Ankyrin repeat and SOCS box protein 2 (ASB-2)| Length = 634 Score = 53.5 bits (127), Expect = 5e-07 Identities = 34/107 (31%), Positives = 54/107 (50%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE ++ + A+ + G ALH + +L+ EIL+ GA V+A + TPL Sbjct: 217 NAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLF 276 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G+ E + L KHGA + Q D + + A N ++VV+ L Sbjct: 277 VAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFL 323 Score = 52.0 bits (123), Expect = 2e-06 Identities = 35/109 (32%), Positives = 52/109 (47%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEA-GAAVDALDKNKNTP 467 GD E LK + G N E + EG LH A YG+L C ++L +A +D + T Sbjct: 116 GDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETA 175 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L+ A +C+ LL+ GA + N +TP+ A E V++L Sbjct: 176 LYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRIL 224 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/110 (26%), Positives = 51/110 (46%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S D E ++ + GGA + ++V L A G+L+ L + GA ++ + + Sbjct: 247 SRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSAS 306 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L+ A+ ++ V+ LL GA N DG P+ VA +V++L Sbjct: 307 ALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQML 356 Score = 30.4 bits (67), Expect = 4.8 Identities = 25/65 (38%), Positives = 34/65 (52%), Gaps = 4/65 (6%) Frame = -3 Query: 580 EGRR--ALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYGRKECVDLLLK 413 E RR AL+FA + E+LL AGA D N++ +PL A +G + LLL Sbjct: 408 EDRRSSALYFAVVNNNVYATELLLLAGA-----DPNRDVISPLLVAIRHGCLRTMQLLLD 462 Query: 412 HGAAV 398 HGA + Sbjct: 463 HGANI 467
>V018_FOWPV (Q9J5I3) Putative ankyrin repeat protein FPV018| Length = 700 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/99 (36%), Positives = 48/99 (48%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K + GAN +E D G L G++ E LL GA V+ D +KNT L YA Sbjct: 445 IKVLIKNGANVNERDNYGITPLMICSREGKVSNMEYLLANGADVNQTDYDKNTALTYAIR 504 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEV 332 KEC +LL+HGA + N TPI + K + V Sbjct: 505 NKSKECTRVLLEHGADMCFMN-RFHTPITIHKTHDNPAV 542 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/110 (25%), Positives = 54/110 (49%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S+ + + ++ GA+ + + G+ +H AC Y ++ ++L++ GA V+ D T Sbjct: 405 SINTSRLTRLLINKGADVNVRNRYGKTPIHLACMYSKIGNIKVLIKNGANVNERDNYGIT 464 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PL + G+ ++ LL +GA V + D T + A N E ++L Sbjct: 465 PLMICSREGKVSNMEYLLANGADVNQTDYDKNTALTYAIRNKSKECTRVL 514 Score = 37.0 bits (84), Expect = 0.051 Identities = 19/69 (27%), Positives = 36/69 (52%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 +H A + +L+ GA V+ ++ TP+H A Y + + +L+K+GA V ++ Sbjct: 400 IHAAVSINTSRLTRLLINKGADVNVRNRYGKTPIHLACMYSKIGNIKVLIKNGANVNERD 459 Query: 385 LDGKTPIEV 359 G TP+ + Sbjct: 460 NYGITPLMI 468 Score = 33.5 bits (75), Expect = 0.56 Identities = 18/50 (36%), Positives = 27/50 (54%) Frame = -3 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 P+H A LL+ GA V ++N GKTPI +A + S+ +K+L Sbjct: 399 PIHAAVSINTSRLTRLLINKGADVNVRNRYGKTPIHLACMYSKIGNIKVL 448
>PA2G6_HUMAN (O60733) 85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4)| (iPLA2) (CaI-PLA2) (Group VI phospholipase A2) (GVI PLA2) Length = 806 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 4/111 (3%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE + L G N + G ALH A CA +LL GA DA ++ NTPLH Sbjct: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI----EVAKLNSQDEVVKLL 320 A E + L+ GA V N G+TP ++ +L ++ ++ LL Sbjct: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLL 406
>ASB5_RABIT (Q862Z2) Ankyrin repeat and SOCS box protein 5 (ASB-5)| Length = 329 Score = 53.5 bits (127), Expect = 5e-07 Identities = 32/88 (36%), Positives = 45/88 (51%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G L+ L G N + ++ LH AC + CA LLEAGA V+A+ + T Sbjct: 79 SQGRLLALRTLLSQGYNVNAVTIDHITPLHEACLGDHVACARTLLEAGANVNAITIDGVT 138 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQN 386 PL A G C +LLL++GA L++ Sbjct: 139 PLFNACSQGSTSCTELLLEYGAKAQLES 166 Score = 50.1 bits (118), Expect = 6e-06 Identities = 33/92 (35%), Positives = 45/92 (48%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GAN + ++G L AC G C E+LLE GA L+ +P H AA G Sbjct: 123 LEAGANVNAITIDGVTPLFNACSQGSTSCTELLLEYGAKAQ-LESCLPSPTHEAASKGHH 181 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 E +DLL+ G V TP+ VA ++ Q Sbjct: 182 EFLDLLISWGIDVDQDIPHLGTPLYVACMSQQ 213 Score = 47.4 bits (111), Expect = 4e-05 Identities = 36/109 (33%), Positives = 53/109 (48%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G E L + G + D++ L+ AC + C LL AGA V K +T Sbjct: 177 SKGHHEFLDLLISWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDT 235 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 PLH AA E V+LL++ GA + +N + P++VA +S E + L Sbjct: 236 PLHAAAQQSSTEIVNLLIEFGADINAKNTELLRPVDVATTSSMVERILL 284 Score = 40.8 bits (94), Expect = 0.004 Identities = 27/81 (33%), Positives = 35/81 (43%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G + + R LH A G L LL G V+A+ + TPLH A C Sbjct: 60 GVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTIDHITPLHEACLGDHVACA 119 Query: 427 DLLLKHGAAVMLQNLDGKTPI 365 LL+ GA V +DG TP+ Sbjct: 120 RTLLEAGANVNAITIDGVTPL 140
>TRPA1_DROME (Q7Z020) Transient receptor potential cation channel subfamily A| member 1 (Ankyrin-like with transmembrane domains protein 1) (dANKTM1) Length = 1197 Score = 53.1 bits (126), Expect = 7e-07 Identities = 31/95 (32%), Positives = 47/95 (49%), Gaps = 3/95 (3%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 +E+D G LH+A G ++ E L+ GA ++ + N +PLH+AA YGR V LL Sbjct: 438 NEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLL 497 Query: 415 KHGAAVMLQNLD---GKTPIEVAKLNSQDEVVKLL 320 + N G TP+ ++ VV+LL Sbjct: 498 DSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLL 532 Score = 44.3 bits (103), Expect = 3e-04 Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 3/111 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA---VDALDKNKN 473 G L+ + GA + ++ LHFA YG LL++ ++ D Sbjct: 455 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGM 514 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPLH ++ G V LLL G A++ ++ G+ P+++A ++ E ++LL Sbjct: 515 TPLHISSQQGHTRVVQLLLNRG-ALLHRDHTGRNPLQLAAMSGYTETIELL 564 Score = 40.0 bits (92), Expect = 0.006 Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 8/94 (8%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAA--------VDALDKNKNTPLHYAAGYGRKECVDL 422 G +H A K E+ + G + D N PLH A G + V+L Sbjct: 225 GYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVEL 284 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LK GA + Q D TP+ +A ++VKL+ Sbjct: 285 CLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLM 318 Score = 37.4 bits (85), Expect = 0.039 Identities = 22/80 (27%), Positives = 38/80 (47%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 DV+ LH A + L+ GA ++ALDK +PL AA + V LL++ G Sbjct: 334 DVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLG 393 Query: 406 AAVMLQNLDGKTPIEVAKLN 347 A + +++ + + +N Sbjct: 394 ACISVKDAAARNVLHFVIMN 413 Score = 33.5 bits (75), Expect = 0.56 Identities = 20/78 (25%), Positives = 32/78 (41%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 +D +GR A H A + + + +A D NTPLH A + +D LL Sbjct: 86 KDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSI 145 Query: 409 GAAVMLQNLDGKTPIEVA 356 + N + P+ +A Sbjct: 146 PVDTGVLNEKKQAPVHLA 163 Score = 29.6 bits (65), Expect = 8.1 Identities = 20/105 (19%), Positives = 44/105 (41%), Gaps = 2/105 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 L+ D + + +D G LH A + LL L++ K P+H A Sbjct: 106 LRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATE 165 Query: 448 YGRKECVDLLLKHGAAVMLQ--NLDGKTPIEVAKLNSQDEVVKLL 320 + + + ++ ++ + +Q G+T + +A + +E ++L Sbjct: 166 LNKVKSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARIL 210
>ASB1_MOUSE (Q9WV74) Ankyrin repeat and SOCS box protein 1 (ASB-1)| Length = 336 Score = 53.1 bits (126), Expect = 7e-07 Identities = 28/70 (40%), Positives = 45/70 (64%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA D DV+G+ AL+ A G L+ EILLEAGA + +++TP+++A+ GR + + Sbjct: 102 GAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDIL 161 Query: 427 DLLLKHGAAV 398 L+++GA V Sbjct: 162 KALIRYGADV 171 Score = 40.4 bits (93), Expect = 0.005 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 8/90 (8%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKN--------TPLHYAAGYGRKECVDLLLKH 410 LH A G+L+ LL+ + +++ TPL AA G CVD L++ Sbjct: 42 LHDAAYVGDLQTLRNLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGNCVDFLIRK 101 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 GA V L ++ G+T + VA +N E ++L Sbjct: 102 GAEVDLVDVKGQTALYVAVVNGHLESTEIL 131 Score = 31.6 bits (70), Expect = 2.1 Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 2/63 (3%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY-GRKECV-DLLLKHGAAVML 392 L+ + Y L+C +LL+AGA D N N P++ Y G CV D +L+HG Sbjct: 197 LYISAAYHNLQCFRLLLQAGANPDF---NCNGPVNTQEFYRGSPGCVMDAVLRHGCEAAF 253 Query: 391 QNL 383 +L Sbjct: 254 VSL 256
>USH1G_MOUSE (Q80T11) Usher syndrome type-1G protein homolog (Scaffold protein| containing ankyrin repeats and SAM domain) (Jackson shaker protein) Length = 461 Score = 53.1 bits (126), Expect = 7e-07 Identities = 34/109 (31%), Positives = 52/109 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E LK+A N +ED G +A +G L+ +++ G D D NTPL Sbjct: 12 GYLELLKEATRKELNAPDED--GMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPL 69 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 H AA G C+ L+ GA + + D TP+++A + E V+ L+ Sbjct: 70 HLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLD 118
>USH1G_HUMAN (Q495M9) Usher syndrome type-1G protein (Scaffold protein| containing ankyrin repeats and SAM domain) Length = 461 Score = 53.1 bits (126), Expect = 7e-07 Identities = 34/109 (31%), Positives = 52/109 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E LK+A N +ED G +A +G L+ +++ G D D NTPL Sbjct: 12 GYLELLKEATRKELNAPDED--GMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPL 69 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLE 317 H AA G C+ L+ GA + + D TP+++A + E V+ L+ Sbjct: 70 HLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLD 118
>ASB9_MOUSE (Q91ZT8) Ankyrin repeat and SOCS box protein 9 (ASB-9)| Length = 290 Score = 53.1 bits (126), Expect = 7e-07 Identities = 32/88 (36%), Positives = 46/88 (52%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN D L+ AC ++ CA+ LLE+G +V+ K ++PLH A E V Sbjct: 153 GANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVNQ-GKGLDSPLHVVARMSSVELV 211 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 LL+ GA +N DGK P+++ L S Sbjct: 212 HLLMDFGANAQAKNADGKRPVDLVPLES 239 Score = 52.0 bits (123), Expect = 2e-06 Identities = 26/54 (48%), Positives = 34/54 (62%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGA 404 LH AC G L CA +LL GA V+ + + TPL A G ++CV+LLL+HGA Sbjct: 69 LHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGA 122 Score = 45.1 bits (105), Expect = 2e-04 Identities = 28/84 (33%), Positives = 41/84 (48%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A +G L L+ G V+ + + +PLH A G C +LL HGA V Sbjct: 36 LHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMT 95 Query: 385 LDGKTPIEVAKLNSQDEVVKLLEQ 314 +D +TP+ A ++ + V LL Q Sbjct: 96 IDWRTPLFNACVSGSQDCVNLLLQ 119 Score = 37.7 bits (86), Expect = 0.030 Identities = 33/108 (30%), Positives = 46/108 (42%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + + L GA E E +H A G +KC E L GA +D + TPL Sbjct: 109 GSQDCVNLLLQHGATPHPE-TELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPL 167 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A + C LL+ G +V Q +P+ V S E+V LL Sbjct: 168 YVACKNQQVACAKKLLESGVSVN-QGKGLDSPLHVVARMSSVELVHLL 214
>ASB12_HUMAN (Q8WXK4) Ankyrin repeat and SOCS box protein 12 (ASB-12)| Length = 309 Score = 53.1 bits (126), Expect = 7e-07 Identities = 30/84 (35%), Positives = 46/84 (54%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 L A YG L C ++LL GA VD+LD TPL A +G +CV +LL+ GA+ Sbjct: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127 Query: 385 LDGKTPIEVAKLNSQDEVVKLLEQ 314 + +P+ A ++D V +L++ Sbjct: 128 YNNCSPVLTA---ARDGAVAILQE 148 Score = 48.5 bits (114), Expect = 2e-05 Identities = 34/102 (33%), Positives = 48/102 (47%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G L+ L GA+ D DV+ + L A +G L C +LLEAGA+ N + Sbjct: 73 SYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCS 132 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 P+ AA G + LL HGA N+ K P+ + + S Sbjct: 133 PVLTAARDGAVAILQELLDHGAEA---NVKAKLPVWASNIAS 171 Score = 38.1 bits (87), Expect = 0.023 Identities = 19/51 (37%), Positives = 29/51 (56%) Frame = -3 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPL AA YG C+ +LL HGA V ++ +TP+ A + + V++L Sbjct: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVL 116
>ASB2_RAT (Q5U2S6) Ankyrin repeat and SOCS box protein 2 (ASB-2)| Length = 634 Score = 53.1 bits (126), Expect = 7e-07 Identities = 34/107 (31%), Positives = 54/107 (50%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE ++ + A+ + G ALH + +L+ EIL+ GA V+A + TPL Sbjct: 217 NAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLF 276 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G+ E + L KHGA + Q D + + A N ++VV+ L Sbjct: 277 VAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFL 323 Score = 52.8 bits (125), Expect = 9e-07 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 1/111 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEA-GAAVDALDKNKNTP 467 GD E LK + G N E + EG LH A YG+L C ++L A +D + T Sbjct: 116 GDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETA 175 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 L+ A +C+ LL+ GA + N +TP+ A E V++L Q Sbjct: 176 LYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQ 226 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/110 (26%), Positives = 50/110 (45%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S D E ++ + GGA + ++V L A G+L+ L + GA ++ + + Sbjct: 247 SRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSAS 306 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L+ A ++ V+ LL GA N DG P+ VA +V++L Sbjct: 307 ALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQML 356 Score = 30.4 bits (67), Expect = 4.8 Identities = 25/65 (38%), Positives = 34/65 (52%), Gaps = 4/65 (6%) Frame = -3 Query: 580 EGRR--ALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYGRKECVDLLLK 413 E RR AL+FA + E+LL AGA D N++ +PL A +G + LLL Sbjct: 408 EDRRTSALYFAVVNNNVYATELLLLAGA-----DPNRDVISPLLVAIRHGCLRTMQLLLD 462 Query: 412 HGAAV 398 HGA + Sbjct: 463 HGANI 467
>AKR1_ASPFU (Q4X251) Palmitoyltransferase akr1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein akr1) Length = 738 Score = 53.1 bits (126), Expect = 7e-07 Identities = 30/80 (37%), Positives = 42/80 (52%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D +G L +A G C ++ L GA V+A+D TPLH+A G CV L+ Sbjct: 191 DVIDQQGHTGLMWAAYKGYPACVDLFLRWGANVNAVDDGGLTPLHWALVKGSLPCVQKLI 250 Query: 415 KHGAAVMLQNLDGKTPIEVA 356 ++GA + DGK+P VA Sbjct: 251 EYGADRFAKTRDGKSPATVA 270 Score = 47.4 bits (111), Expect = 4e-05 Identities = 37/101 (36%), Positives = 49/101 (48%), Gaps = 1/101 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ DV+G LH A G +LL VD +D+ +T L +AA G Sbjct: 151 LQHGADPLLTDVQGYNILHLATIDGNAFLLVLLLHQEIPVDVIDQQGHTGLMWAAYKGYP 210 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKL-NSQDEVVKLLE 317 CVDL L+ GA V + G TP+ A + S V KL+E Sbjct: 211 ACVDLFLRWGANVNAVDDGGLTPLHWALVKGSLPCVQKLIE 251 Score = 38.5 bits (88), Expect = 0.017 Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 2/96 (2%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNK-NTPLHYAAGYGRKECVDLLLK 413 +D EG LH+A + + LL+ GA V+A + TP +AA V LLL+ Sbjct: 93 QDEEGITPLHWAAINNQYAMCKFLLDNGADVNAKGGDSVATPAMWAAQRCHYYIVHLLLQ 152 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQD-EVVKLLEQDV 308 HGA +L ++ G + +A ++ +V LL Q++ Sbjct: 153 HGADPLLTDVQGYNILHLATIDGNAFLLVLLLHQEI 188
>DDFL1_MOUSE (Q5U464) Development and differentiation enhancing factor-like 1| Length = 904 Score = 52.8 bits (125), Expect = 9e-07 Identities = 32/91 (35%), Positives = 49/91 (53%), Gaps = 3/91 (3%) Frame = -3 Query: 577 GRRALHFA---CGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 G ALH A + L + L++ G +DA + NT LH AA +G+ +C+ LLL+ Sbjct: 585 GELALHLAIRVASHASLPIVDFLIQNGGHLDAKAADGNTALHCAALHGQLDCLKLLLRGR 644 Query: 406 AAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 A V N G+T +++A+ E +LLEQ Sbjct: 645 APVGAVNDAGETALDIARNRQHKECEELLEQ 675 Score = 43.5 bits (101), Expect = 5e-04 Identities = 23/66 (34%), Positives = 34/66 (51%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 + G + D + +G ALH A +G+L C ++LL A V A++ T L A K Sbjct: 608 IQNGGHLDAKAADGNTALHCAALHGQLDCLKLLLRGRAPVGAVNDAGETALDIARNRQHK 667 Query: 436 ECVDLL 419 EC +LL Sbjct: 668 ECEELL 673
>DDFL1_HUMAN (Q8TDY4) Development and differentiation enhancing factor-like 1| (Protein up-regulated in liver cancer 1) Length = 903 Score = 52.8 bits (125), Expect = 9e-07 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 3/87 (3%) Frame = -3 Query: 565 LHFA---CGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVM 395 LH A L + +++ G +DA + NT LHYAA Y + +C+ LLLK A V Sbjct: 590 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 649 Query: 394 LQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 N G+T +++A+ E +LLEQ Sbjct: 650 TVNEAGETALDIARKKHHKECEELLEQ 676
>PA2G6_RAT (P97570) 85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4)| (iPLA2) (CaI-PLA2) (Group VI phospholipase A2) (GVI PLA2) Length = 751 Score = 52.8 bits (125), Expect = 9e-07 Identities = 35/101 (34%), Positives = 46/101 (45%), Gaps = 1/101 (0%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE + L G + D G ALH A C +LL GA A ++ NTPLH Sbjct: 295 NAEMARMLLKRGCDVDSTSASGNTALHVAVTRNRFDCVMVLLTYGANAGARGEHGNTPLH 354 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQ 341 A E V L+ GA V N G+TP +A K++ Q Sbjct: 355 LAMSKDNMEMVKALIVFGAEVDTPNDFGETPAFIASKISKQ 395 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/100 (31%), Positives = 48/100 (48%) Frame = -3 Query: 619 ALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 ++D ++ G LH+A + A +LL+ G VD+ + NT LH A R Sbjct: 272 SMDSNQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCDVDSTSASGNTALHVAVTRNR 328 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +CV +LL +GA + G TP+ +A E+VK L Sbjct: 329 FDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKAL 368
>TRPA1_CAEEL (Q18297) Transient receptor potential cation channel subfamily A| member 1 homolog Length = 1193 Score = 52.8 bits (125), Expect = 9e-07 Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 3/91 (3%) Frame = -3 Query: 574 RRALHFACGYGELKCA-EILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 R +H + G + E LL+A AV+A D + TPLHYAA YG + V LLL A Sbjct: 33 RSIIHQSAREGNVNALQEALLKAPLAVNAQDGDFMTPLHYAARYGNYDAVKLLLSKNALP 92 Query: 397 MLQNLDGKTPIEVAK--LNSQDEVVKLLEQD 311 +N +G TP+ +A + ++ ++++D Sbjct: 93 NTKNREGDTPLHIASKYIYGYSDICSIIDED 123 Score = 49.7 bits (117), Expect = 8e-06 Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 1/106 (0%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD GA+K+ ++ + L A G+L+ + L+ GA +++ K T LH AA Y Sbjct: 540 KVLLDNGADKEAKNSYQKTPLQVAVDSGKLETCQRLVAKGAQIESSSDTK-TVLHTAAFY 598 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQD 311 G + V + G + ++ +GKT ++A N +V + LE D Sbjct: 599 GNESIVRYFIAEGVTIDRRDEEGKTAFDIACENDHKDVARAFLETD 644 Score = 49.3 bits (116), Expect = 1e-05 Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 2/111 (1%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTP 467 G E LK ++ G NK+E + LH A +L+ L+E +D +D+ TP Sbjct: 305 GFLEVLKALVEAGGNKNELNEVKAVPLHVAAQMNQLEVVSYLIEEEKDNIDVVDEQGLTP 364 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEV-AKLNSQDEVVKLLE 317 L A + K+CV+ L+ A + + + D +TP+ + AK N+ V +L+ Sbjct: 365 LMMAVTHDSKKCVEYLIAKKANLTITDKDERTPVFIGAKFNALSSVEYILD 415 Score = 47.8 bits (112), Expect = 3e-05 Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 1/67 (1%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-L 323 V+ +D+++NTP+H A G E + LL KHGA++ N D +T + A + Q V+ L Sbjct: 449 VNMVDRDQNTPMHIVASNGYLEMMQLLQKHGASITQVNEDEETALHRAAIGGQTGAVRQL 508 Query: 322 LEQDVFL 302 LE D+ L Sbjct: 509 LEWDIRL 515 Score = 41.2 bits (95), Expect = 0.003 Identities = 26/88 (29%), Positives = 41/88 (46%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 +D G ALH A G ++LL+ GA +A + + TPL A G+ E L+ Sbjct: 519 KDEMGNSALHLAARSGHDATTKVLLDNGADKEAKNSYQKTPLQVAVDSGKLETCQRLVAK 578 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVK 326 GA + + D KT + A + +V+ Sbjct: 579 GAQIE-SSSDTKTVLHTAAFYGNESIVR 605 Score = 39.7 bits (91), Expect = 0.008 Identities = 23/82 (28%), Positives = 39/82 (47%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH+A L++ A VDA D NK TPL A +G +E + L+K + V ++ Sbjct: 160 LHYAAMKSNFSALHALIKLKADVDAEDDNKMTPLLLACVHGSQEIIQELIKANSNVTKRD 219 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 T + L + E ++++ Sbjct: 220 QRLNTVFHIVALRGEPEYLEMM 241 Score = 38.1 bits (87), Expect = 0.023 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 1/86 (1%) Frame = -3 Query: 574 RRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGA-AV 398 + +HFA G L+ + L+EAG + L++ K PLH AA + E V L++ + Sbjct: 295 KELIHFAAEKGFLEVLKALVEAGGNKNELNEVKAVPLHVAAQMNQLEVVSYLIEEEKDNI 354 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + G TP+ +A + + V+ L Sbjct: 355 DVVDEQGLTPLMMAVTHDSKKCVEYL 380 Score = 38.1 bits (87), Expect = 0.023 Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 24/132 (18%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFAC----GYGEL-------------------- 536 G+ + +K L A + ++ EG LH A GY ++ Sbjct: 77 GNYDAVKLLLSKNALPNTKNREGDTPLHIASKYIYGYSDICSIIDEDQADSARKYNTATK 136 Query: 535 KCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 K L+ A +D ++K + TPLHYAA + L+K A V ++ + TP+ +A Sbjct: 137 KIINALVSENAEIDPVNKYQLTPLHYAAMKSNFSALHALIKLKADVDAEDDNKMTPLLLA 196 Query: 355 KLNSQDEVVKLL 320 ++ E+++ L Sbjct: 197 CVHGSQEIIQEL 208 Score = 34.7 bits (78), Expect = 0.25 Identities = 19/64 (29%), Positives = 29/64 (45%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N D D +G L A + KC E L+ A + DK++ TP+ A + V+ Sbjct: 353 NIDVVDEQGLTPLMMAVTHDSKKCVEYLIAKKANLTITDKDERTPVFIGAKFNALSSVEY 412 Query: 421 LLKH 410 +L H Sbjct: 413 ILDH 416 Score = 33.5 bits (75), Expect = 0.56 Identities = 19/67 (28%), Positives = 33/67 (49%), Gaps = 1/67 (1%) Frame = -3 Query: 643 GDAEGLKKAL-DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G+ L++AL + +D + LH+A YG ++LL A + ++ +TP Sbjct: 43 GNVNALQEALLKAPLAVNAQDGDFMTPLHYAARYGNYDAVKLLLSKNALPNTKNREGDTP 102 Query: 466 LHYAAGY 446 LH A+ Y Sbjct: 103 LHIASKY 109
>ASB4_HUMAN (Q9Y574) Ankyrin repeat and SOCS box protein 4 (ASB-4)| Length = 426 Score = 52.8 bits (125), Expect = 9e-07 Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 2/99 (2%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-- 473 + + + +K D GA + + G ALHF + CA+ L+ GA V+ N++ Sbjct: 117 MANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEE 176 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 TPLH AA +G E V ++HGA V N +TP+ +A Sbjct: 177 TPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIA 215 Score = 41.6 bits (96), Expect = 0.002 Identities = 25/85 (29%), Positives = 40/85 (47%), Gaps = 2/85 (2%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G+ LH AC + C +IL + GA ++ + +T LH+ C L+ GA V Sbjct: 107 GKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANV 166 Query: 397 MLQ--NLDGKTPIEVAKLNSQDEVV 329 ++ N D +TP+ A E+V Sbjct: 167 NMKTNNQDEETPLHTAAHFGLSELV 191 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/67 (31%), Positives = 34/67 (50%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH + +G ++C +LL+ A ++ K TPLH A +CV +L GA + + Sbjct: 79 LHLSVLFGHVECLLVLLDHNATINCRPNGK-TPLHVACEMANVDCVKILCDRGAKLNCYS 137 Query: 385 LDGKTPI 365 L G T + Sbjct: 138 LSGHTAL 144 Score = 33.9 bits (76), Expect = 0.43 Identities = 19/51 (37%), Positives = 30/51 (58%) Frame = -3 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LH + +G EC+ +LL H A + + +GKTP+ VA + + VK+L Sbjct: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKIL 126
>ASZ1_OTOGA (Q2QLH1) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 52.4 bits (124), Expect = 1e-06 Identities = 43/117 (36%), Positives = 61/117 (52%), Gaps = 6/117 (5%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFAC---GYGE--LKCAEILLEAGAAVDALD 485 SV + E ++ LD GAN D + + L AC G E LKC E+LL A + Sbjct: 88 SVANVELVRVLLDRGANASF-DKDKQTILITACSARGLEEQILKCVELLLSRNADPNVAC 146 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 + TP+ YAA G + V LL+ HGA V Q+ +G T + A+ ++ V+KLLE Sbjct: 147 RRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLE 203 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/80 (40%), Positives = 42/80 (52%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ L Sbjct: 215 GKIPSEIAKRNKHLEIFNFL 234 Score = 34.3 bits (77), Expect = 0.33 Identities = 31/122 (25%), Positives = 57/122 (46%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + + L G +E++ ++AL G++ + LL++G +VD+ + TP Sbjct: 27 IGYLDRASQKLKGPLPIEEKNETFKKALTT----GDISLVQELLDSGISVDSSFRYGWTP 82 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPS 287 L YAA E V +LL GA K I + +++ ++L+ L S+ + Sbjct: 83 LMYAASVANVELVRVLLDRGANASFDK--DKQTILITACSARGLEEQILKCVELLLSRNA 140 Query: 286 DP 281 DP Sbjct: 141 DP 142
>ASZ1_MICMU (Q2QL84) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 481 Score = 52.4 bits (124), Expect = 1e-06 Identities = 32/80 (40%), Positives = 42/80 (52%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D+N T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 GK P E+AK N E+ L Sbjct: 215 GKIPSEIAKRNKHLEIFNFL 234 Score = 50.4 bits (119), Expect = 4e-06 Identities = 41/117 (35%), Positives = 61/117 (52%), Gaps = 6/117 (5%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFAC---GYGE--LKCAEILLEAGAAVDALD 485 S+ + E ++ LD GAN D + + L AC G E LKC E+LL A + Sbjct: 88 SIANVELVRVLLDRGANASF-DKDKQTILITACSARGSEEQILKCVELLLSRNADPNVAC 146 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 + TP+ YAA G + V +L+ HGA V Q+ +G T + A+ ++ V+KLLE Sbjct: 147 RRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLE 203 Score = 36.2 bits (82), Expect = 0.087 Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 2/90 (2%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G++ + LL++G +VD+ + TPL YAA E V +LL GA D +T + Sbjct: 57 GDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASFDK-DKQTIL 115 Query: 364 EVA--KLNSQDEVVKLLEQDVFL*SKPSDP 281 A S+++++K +E L S+ +DP Sbjct: 116 ITACSARGSEEQILKCVE---LLLSRNADP 142
>AKR1_NEUCR (Q7S3M5) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 729 Score = 52.4 bits (124), Expect = 1e-06 Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 1/102 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G D ED G AL ++ G C ++ L GA+V A D+ T LH+A G Sbjct: 164 LHQGIPVDVEDAYGHTALMWSAYKGFPACVDVFLRWGASVHAKDEQGFTALHWALVKGSP 223 Query: 436 ECVDLLLKHGAAVMLQNLDGKTP-IEVAKLNSQDEVVKLLEQ 314 C+ L+++GA + +GKTP I +LN+ K L++ Sbjct: 224 GCIQKLIEYGADRFAKTANGKTPAITAQELNTVAAWQKALDE 265 Score = 43.5 bits (101), Expect = 5e-04 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 2/111 (1%) Frame = -3 Query: 646 VGDAEGLKKALDGGA-NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALD-KNKN 473 VGD G++K G + D EG LH+A + + L++ GA ++ ++ Sbjct: 53 VGDITGMEKLFAAGEYDATYSDDEGITPLHWAAINNQYAMCKFLIDKGAEINKKGGESVA 112 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPL +AA V LLL+HGA ++ + G + ++ N ++ LL Sbjct: 113 TPLQWAAQRCHYYTVHLLLQHGADPLITDSQGYNTLHISTFNGNVLLIVLL 163
>Y714_RICPR (Q9ZCL3) Hypothetical ANK-repeat protein RP714| Length = 107 Score = 52.4 bits (124), Expect = 1e-06 Identities = 31/80 (38%), Positives = 38/80 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+ E + L G + D D G ALH A G K A +LL GA +DA + TPL Sbjct: 19 GNIEYTSELLQNGVDIDVRDKNGNSALHIAASKGYTKIATMLLLYGATIDAPNFELATPL 78 Query: 463 HYAAGYGRKECVDLLLKHGA 404 HYAA K+ LL A Sbjct: 79 HYAAANNYKDLTQYLLNMNA 98 Score = 47.4 bits (111), Expect = 4e-05 Identities = 24/75 (32%), Positives = 39/75 (52%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G ++ LL+ G +D DKN N+ LH AA G + +LL +GA + N + TP+ Sbjct: 19 GNIEYTSELLQNGVDIDVRDKNGNSALHIAASKGYTKIATMLLLYGATIDAPNFELATPL 78 Query: 364 EVAKLNSQDEVVKLL 320 A N+ ++ + L Sbjct: 79 HYAAANNYKDLTQYL 93
>V246_FOWPV (Q9J4Z4) Putative ankyrin repeat protein FPV246| Length = 592 Score = 52.4 bits (124), Expect = 1e-06 Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 1/102 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKN-KNTP 467 G+ + K ++ GA+ + ++ G LH A YG + +LL G ++DA DK +TP Sbjct: 331 GNKDISKLLIEKGADPNISNIHGYTPLHNAAAYGSVDVVNLLLSYGVSIDAKDKIIGSTP 390 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQ 341 L + G E V LLL+ GA NL G TP++ A L S+ Sbjct: 391 LDH--GVHHPEIVKLLLEKGANPNTINLYGYTPLKNAILKSR 430 Score = 51.2 bits (121), Expect = 3e-06 Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E + + G+ D +D G L ACG ++ +++L+E GA + + + TPL Sbjct: 300 GSVETVNALISYGSTVDIKDNIGSTPLMHACGNKDI--SKLLIEKGADPNISNIHGYTPL 357 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQN-LDGKTPIEVAKLNSQDEVVKLL 320 H AA YG + V+LLL +G ++ ++ + G TP++ E+VKLL Sbjct: 358 HNAAAYGSVDVVNLLLSYGVSIDAKDKIIGSTPLDHGV--HHPEIVKLL 404 Score = 39.3 bits (90), Expect = 0.010 Identities = 25/75 (33%), Positives = 39/75 (52%) Frame = -3 Query: 544 GELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 G + LL+ G V++ D TPLH A G E V+ L+ +G+ V +++ G TP+ Sbjct: 267 GYINVIHFLLDIGFNVNSFDSFGETPLHAATRSGSVETVNALISYGSTVDIKDNIGSTPL 326 Query: 364 EVAKLNSQDEVVKLL 320 A N ++ KLL Sbjct: 327 MHACGNK--DISKLL 339 Score = 35.8 bits (81), Expect = 0.11 Identities = 22/72 (30%), Positives = 38/72 (52%) Frame = -3 Query: 541 ELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 ELK A++L+ GA +D ++ TPL G LLL +GA ++ +G T E Sbjct: 175 ELKIAQLLISRGAKLDIKNEYGYTPLRNTVINGNFALTKLLLDNGADASIK-CNGMTIFE 233 Query: 361 VAKLNSQDEVVK 326 ++ L+ +++K Sbjct: 234 ISTLSQNVDMIK 245
>ASB4_MOUSE (Q9WV71) Ankyrin repeat and SOCS box protein 4 (ASB-4)| Length = 426 Score = 52.4 bits (124), Expect = 1e-06 Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 2/99 (2%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-- 473 + + E +K D GA + + G ALHF + CA+ L+ GA V+ N++ Sbjct: 117 IANLECVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVLRGANVNMKTNNQDEE 176 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 TPLH AA +G E V +++GA V N +TP+ +A Sbjct: 177 TPLHTAAHFGLSELVAFYVENGAIVDSMNAHMETPLAIA 215 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 2/108 (1%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G E L LD A + G+ LH AC L+C +IL + GA ++ + +T Sbjct: 85 LGHVECLMVLLDHNATINCRP-NGKTPLHVACEIANLECVKILCDRGAKLNCYSLSGHTA 143 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQ--NLDGKTPIEVAKLNSQDEVV 329 LH+ C L+ GA V ++ N D +TP+ A E+V Sbjct: 144 LHFCTTPSSILCAKQLVLRGANVNMKTNNQDEETPLHTAAHFGLSELV 191 Score = 33.1 bits (74), Expect = 0.73 Identities = 20/51 (39%), Positives = 29/51 (56%) Frame = -3 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 T LH + G EC+ +LL H A + + +GKTP+ VA + E VK+L Sbjct: 77 TGLHLSVLLGHVECLMVLLDHNATINCRP-NGKTPLHVACEIANLECVKIL 126 Score = 31.2 bits (69), Expect = 2.8 Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 7/79 (8%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 LD A + D + + LH A + ++LEAGA + +D N + Y Sbjct: 239 LDNNAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSV 298 Query: 436 E-------CVDLLLKHGAA 401 C LLL HGAA Sbjct: 299 RPAAQPEICYQLLLNHGAA 317
>ASB1_HUMAN (Q9Y576) Ankyrin repeat and SOCS box protein 1 (ASB-1)| Length = 335 Score = 52.0 bits (123), Expect = 2e-06 Identities = 27/70 (38%), Positives = 45/70 (64%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA D DV+G+ AL+ A G L+ +ILLEAGA + +++TP+++A+ GR + + Sbjct: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160 Query: 427 DLLLKHGAAV 398 L+++GA V Sbjct: 161 KALIRYGADV 170 Score = 40.8 bits (94), Expect = 0.004 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 8/90 (8%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKN--------TPLHYAAGYGRKECVDLLLKH 410 LH A G+L+ LL+ + +++ TPL AA G CVD L++ Sbjct: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 GA V L ++ G+T + VA +N E ++L Sbjct: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQIL 130 Score = 31.2 bits (69), Expect = 2.8 Identities = 33/105 (31%), Positives = 47/105 (44%), Gaps = 17/105 (16%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEE-----DVEGRRA----------LHFACGYGELKCAEILLE 512 VG A+ LK + GA+ D DV+ R + L+ + Y L+C +LL Sbjct: 154 VGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLL 213 Query: 511 AGAAVDALDKNKNTPLHYAAGY-GRKECV-DLLLKHGAAVMLQNL 383 AGA D N N P++ Y G CV D +L+HG +L Sbjct: 214 AGANPDF---NCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSL 255
>YL093_MIMIV (Q5UPG5) Putative ankyrin repeat protein L93| Length = 421 Score = 52.0 bits (123), Expect = 2e-06 Identities = 30/79 (37%), Positives = 45/79 (56%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E +K LD GA+ + + EG AL FAC Y ++ ++LL+ A ++A DK+ TPL +A Sbjct: 339 EIIKLLLDKGADINTGNGEGWTALMFACKYANIEAIKLLLDKNADINAKDKDGWTPLMFA 398 Query: 454 AGYGRKECVDLLLKHGAAV 398 Y E + LLL A + Sbjct: 399 CVYANIETIKLLLDKRADI 417 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 4/109 (3%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGE----LKCAEILLEAGAAVDALDKNKNTP 467 E +K LD A+ + +D G AL AC Y ++ ++LL+ GA ++ + T Sbjct: 302 EAIKLLLDKNADINAKDKIGLTALMLACKYANTPNSIEIIKLLLDKGADINTGNGEGWTA 361 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L +A Y E + LLL A + ++ DG TP+ A + + E +KLL Sbjct: 362 LMFACKYANIEAIKLLLDKNADINAKDKDGWTPLMFACVYANIETIKLL 410 Score = 47.0 bits (110), Expect = 5e-05 Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 8/111 (7%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGY----GELKCAEILLEAGAAVDALDKNKNTPLH 461 +K L+ G+N DE D G AL AC Y +K ++LL+ GA + DK T L Sbjct: 197 VKLLLNRGSNIDELDNNGWTALMIACKYANTTSNIKTIKLLLDRGADTNIKDKIGLTALM 256 Query: 460 YAAGYGRK----ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 A Y E + LLL GA + N +G T + A + E +KLL Sbjct: 257 LACKYANTPNSIEIIKLLLDKGADINTGNGEGWTALMFACKYANIEAIKLL 307 Score = 34.7 bits (78), Expect = 0.25 Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 8/80 (10%) Frame = -3 Query: 535 KCAEILLEAGAAVDALDKNKNTPLHYAA----GYGRKECVDLLLKHGAAVMLQNLDGKTP 368 K +LL GA V+ + K T L A+ G + V LLL + A + + + DG T Sbjct: 84 KTVNLLLSKGAKVNLMKNEKQTVLMLASLNSRQIGSTDIVKLLLDYDAKIDISDEDGWTA 143 Query: 367 IEVAKLNSQDE----VVKLL 320 + A +NS + VKLL Sbjct: 144 LMYASINSNESSTIATVKLL 163
>ZDH13_PONPY (Q5NVB9) Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc| finger DHHC domain-containing protein 13) (DHHC-13) Length = 622 Score = 52.0 bits (123), Expect = 2e-06 Identities = 24/71 (33%), Positives = 47/71 (66%), Gaps = 1/71 (1%) Frame = -3 Query: 520 LLEAGAAVDALDK-NKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 LL+ +++ +DK ++NTPLH+A G VD LL+ G+++ +QN+ G+TP+++A N Sbjct: 202 LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNK 261 Query: 343 QDEVVKLLEQD 311 ++ +L+ + Sbjct: 262 NQLIIHMLKTE 272 Score = 48.5 bits (114), Expect = 2e-05 Identities = 35/109 (32%), Positives = 52/109 (47%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TP 467 G E K+ ++ G + + D E LH+A L + + GA VD L + N TP Sbjct: 60 GIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTP 119 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+A G V LLL+HGA L + +G + I +A L ++ L Sbjct: 120 LHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYL 168 Score = 32.3 bits (72), Expect = 1.3 Identities = 32/97 (32%), Positives = 42/97 (43%), Gaps = 1/97 (1%) Frame = -3 Query: 556 ACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD- 380 A YG + + L+EAG V DK + LH+AA R + V + GA V D Sbjct: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115 Query: 379 GKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 TP+ A +V LL Q +DP LID Sbjct: 116 NSTPLHWAIRQGHLPMVILLLQ------HGADPTLID 146
>ZDH13_MACFA (Q4R690) Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc| finger DHHC domain-containing protein 13) (DHHC-13) Length = 622 Score = 52.0 bits (123), Expect = 2e-06 Identities = 24/71 (33%), Positives = 47/71 (66%), Gaps = 1/71 (1%) Frame = -3 Query: 520 LLEAGAAVDALDK-NKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 LL+ +++ +DK ++NTPLH+A G VD LL+ G+++ +QN+ G+TP+++A N Sbjct: 202 LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNK 261 Query: 343 QDEVVKLLEQD 311 ++ +L+ + Sbjct: 262 NQLIIHMLKTE 272 Score = 49.3 bits (116), Expect = 1e-05 Identities = 35/109 (32%), Positives = 52/109 (47%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TP 467 G E K+ ++ G + + D E LH+A L + + GA VD L + N TP Sbjct: 60 GIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTP 119 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+A G V LLL+HGA L + +G + I +A L ++ L Sbjct: 120 LHWAIRQGHLPMVILLLQHGADPTLTDGEGFSSIHLAVLFQHMPIIAYL 168 Score = 30.4 bits (67), Expect = 4.8 Identities = 31/97 (31%), Positives = 41/97 (42%), Gaps = 1/97 (1%) Frame = -3 Query: 556 ACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD- 380 A YG + + L+EAG V DK + LH+AA R + V + GA V D Sbjct: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115 Query: 379 GKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 TP+ A +V LL Q +DP L D Sbjct: 116 NSTPLHWAIRQGHLPMVILLLQ------HGADPTLTD 146
>ZDH13_HUMAN (Q8IUH4) Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc| finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin-interacting protein HIP3RP) (Putativ Length = 622 Score = 52.0 bits (123), Expect = 2e-06 Identities = 24/71 (33%), Positives = 47/71 (66%), Gaps = 1/71 (1%) Frame = -3 Query: 520 LLEAGAAVDALDK-NKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 LL+ +++ +DK ++NTPLH+A G VD LL+ G+++ +QN+ G+TP+++A N Sbjct: 202 LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNK 261 Query: 343 QDEVVKLLEQD 311 ++ +L+ + Sbjct: 262 NQLIIHMLKTE 272 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TP 467 G E K+ ++ G + + D E LH+A L + GA VD L + N TP Sbjct: 60 GIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVRFYISKGAVVDQLGGDLNSTP 119 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+A G V LLL+HGA L + +G + I +A L ++ L Sbjct: 120 LHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYL 168 Score = 32.0 bits (71), Expect = 1.6 Identities = 32/97 (32%), Positives = 42/97 (43%), Gaps = 1/97 (1%) Frame = -3 Query: 556 ACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD- 380 A YG + + L+EAG V DK + LH+AA R + V + GA V D Sbjct: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVRFYISKGAVVDQLGGDL 115 Query: 379 GKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLID 269 TP+ A +V LL Q +DP LID Sbjct: 116 NSTPLHWAIRQGHLPMVILLLQ------HGADPTLID 146
>PA2G6_MOUSE (P97819) 85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4)| (iPLA2) (CaI-PLA2) (Group VI phospholipase A2) (GVI PLA2) Length = 752 Score = 51.6 bits (122), Expect = 2e-06 Identities = 35/101 (34%), Positives = 46/101 (45%), Gaps = 1/101 (0%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLH 461 +AE + L G + D G ALH A C +LL GA A ++ NTPLH Sbjct: 296 NAEMARMLLKRGCDVDSTSSSGNTALHVAVMRNRFDCVMVLLTYGANAGARGEHGNTPLH 355 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA-KLNSQ 341 A E V L+ GA V N G+TP +A K++ Q Sbjct: 356 LAMSKDNMEMVKALIVFGAEVDTPNDFGETPALIASKISKQ 396 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/100 (31%), Positives = 48/100 (48%) Frame = -3 Query: 619 ALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 ++D ++ G LH+A + A +LL+ G VD+ + NT LH A R Sbjct: 273 SMDSNQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCDVDSTSSSGNTALHVAVMRNR 329 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +CV +LL +GA + G TP+ +A E+VK L Sbjct: 330 FDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKAL 369
>CENG2_HUMAN (Q9UPQ3) Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like,| ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1) Length = 857 Score = 51.6 bits (122), Expect = 2e-06 Identities = 25/58 (43%), Positives = 36/58 (62%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 +GR ALH AC G + A++L+ G V A D + NT L YA +EC+D+LL++G Sbjct: 768 DGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYG 825
>PME5_CAEEL (Q9TXQ1) Poly(ADP-ribose) polymerase pme-5 (EC 2.4.2.30) (Poly| ADP-ribose metabolism enzyme 5) Length = 2276 Score = 51.6 bits (122), Expect = 2e-06 Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 1/116 (0%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 L ACG G L+ A+ L+E GA V+ DK K TPL +A G+ LL GA++ L + Sbjct: 503 LMMACGKGYLEMAKKLVEKGALVEGKDKKKRTPLIHAMLNGQIHTAAFLLAKGASLTLAD 562 Query: 385 LDGKTPIEVAKLNSQDEVVKLLEQ-DVFL*SKPSDPVLIDPKTLPCFWSLSGVMSW 221 G T A + +KLL D + S+P+D L P ++ G+++W Sbjct: 563 SSGNTAAHYAAAYGFLDCLKLLASIDDNILSEPNDWQLY-PLSVAYLKGHYGIVTW 617 Score = 49.7 bits (117), Expect = 8e-06 Identities = 35/109 (32%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E KK ++ GA + +D + R L A G++ A LL GA++ D + NT Sbjct: 510 GYLEMAKKLVEKGALVEGKDKKKRTPLIHAMLNGQIHTAAFLLAKGASLTLADSSGNTAA 569 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKT-PIEVAKLNSQDEVVKLL 320 HYAA YG +C+ LL ++ + D + P+ VA L +V L Sbjct: 570 HYAAAYGFLDCLKLLASIDDNILSEPNDWQLYPLSVAYLKGHYGIVTWL 618 Score = 39.7 bits (91), Expect = 0.008 Identities = 19/40 (47%), Positives = 23/40 (57%) Frame = -3 Query: 535 KCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 KC L++AGA VD D NTPLHYA G +L+L Sbjct: 711 KCFNTLIKAGAKVDVYDHEDNTPLHYALTNGNLMLFNLML 750 Score = 35.4 bits (80), Expect = 0.15 Identities = 29/83 (34%), Positives = 39/83 (46%), Gaps = 4/83 (4%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILL-EAGAAVD---ALDKNKNTPLHYAAGYGRKECVDLLLKH 410 G ALH A L + LL E VD + +N+ TPL A G G E L++ Sbjct: 462 GNSALHLAVLRNNLDVVDALLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVEK 521 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQ 341 GA V ++ +TP+ A LN Q Sbjct: 522 GALVEGKDKKKRTPLIHAMLNGQ 544 Score = 35.0 bits (79), Expect = 0.19 Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 16/96 (16%) Frame = -3 Query: 595 DEEDVEGRRALHFACG-----------YGELKCAEIL-----LEAGAAVDALDKNKNTPL 464 D D R ALH+A G +GE ++ L ++ D N NT L Sbjct: 1117 DAVDKFNRTALHYAFGNENDFKEGNVPFGESDPIAVVSLLSSLIRPEQIEIADVNGNTIL 1176 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H AA C+ L++ V L+N DG TP+ +A Sbjct: 1177 HLAAIKNSTICLMTLIRKKCHVDLKNKDGNTPLALA 1212 Score = 34.7 bits (78), Expect = 0.25 Identities = 21/63 (33%), Positives = 28/63 (44%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 DV G LH A C L+ VD +K+ NTPL A +GR+ L++ Sbjct: 1169 DVNGNTILHLAAIKNSTICLMTLIRKKCHVDLKNKDGNTPLALAVHHGRQSSALTLIQAN 1228 Query: 406 AAV 398 A V Sbjct: 1229 ADV 1231 Score = 32.3 bits (72), Expect = 1.3 Identities = 20/58 (34%), Positives = 26/58 (44%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLK 413 D + +H+A E LL+ G +V L K TPLH AA GR L+K Sbjct: 376 DQDNWYTMHYAACAPGTAPMEFLLKNGGSVTMLTKQTETPLHVAARAGRAVNCTFLMK 433 Score = 31.6 bits (70), Expect = 2.1 Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 5/66 (7%) Frame = -3 Query: 631 GLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEIL-----LEAGAAVDALDKNKNTP 467 GL K ++ + E + +GR LH A + +L L +DA+DK T Sbjct: 1067 GLFKMIESKGVRRETNDDGRSVLHVATLACDGSADSVLEPIAWLSTRCPIDAVDKFNRTA 1126 Query: 466 LHYAAG 449 LHYA G Sbjct: 1127 LHYAFG 1132
>ASB11_MOUSE (Q9CQ31) Ankyrin repeat and SOCS box protein 11 (ASB-11)| Length = 323 Score = 51.6 bits (122), Expect = 2e-06 Identities = 35/110 (31%), Positives = 56/110 (50%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E ++ L N ++E + L+ AC Y + C + LLE GA+VD + +TPL Sbjct: 174 GHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPL 232 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 H A E ++LL +GA + L+N GK+ +++A S LL + Sbjct: 233 HAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLLHE 282 Score = 50.4 bits (119), Expect = 4e-06 Identities = 36/107 (33%), Positives = 52/107 (48%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 LK + G N + + +LH AC G + CA+ LLE GA V+A + TPL A Sbjct: 81 LKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACC 140 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDV 308 G CV++LL+ GA L+ E K ++ + LL +DV Sbjct: 141 SGSAACVNVLLEFGAKAQLEIYLASPIHEAVKRGHRECMEILLTKDV 187 Score = 44.7 bits (104), Expect = 2e-04 Identities = 38/109 (34%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G A + L+ GA K + ++ +H A G +C EILL ++ TPL Sbjct: 142 GSAACVNVLLEFGA-KAQLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPL 200 Query: 463 HYAAGYGRKECVDLLLKHGAAV-MLQNLDGKTPIEVAKLNSQDEVVKLL 320 + A Y R +CV LL+ GA+V Q LD TP+ A S EV+ LL Sbjct: 201 YVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAVRQSSVEVINLL 247
>ANKH_CHRVI (Q06527) Ankyrin homolog precursor| Length = 323 Score = 51.6 bits (122), Expect = 2e-06 Identities = 42/126 (33%), Positives = 62/126 (49%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +GD E + LD GA+ D + G+ AL FA +L+ +LL GA V+A TP Sbjct: 42 IGDTETAAELLDQGAHVDAPNQFGKTALMFAVEGDDLETVALLLSRGADVNARTVAGCTP 101 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPS 287 L +AA G LLL+ GA V + G + +A S+ + ++EQ +F K + Sbjct: 102 LTFAAEAGHIGISALLLERGAHVHDRTRSGWDALMIA---SRHGITDMVEQLLF---KGA 155 Query: 286 DPVLID 269 DP D Sbjct: 156 DPKAAD 161
>Y3287_PSEAE (Q9HYV6) Hypothetical ANK-repeat protein PA3287| Length = 171 Score = 51.2 bits (121), Expect = 3e-06 Identities = 34/110 (30%), Positives = 54/110 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G A+ ++ L A+ D ++ G+ L A G+L E+LL GA V+ + T L Sbjct: 60 GHADTVRLLLAYKADPDLRNLAGQTPLAGAAFKGDLAMVELLLAGGADVEGASADGKTAL 119 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 AA + + E LL HGA Q+ G TP+ A++ + + V LL + Sbjct: 120 MMAAMFNQAEVAASLLAHGARRDAQDAAGLTPLAAARMMNAEATVALLSR 169 Score = 42.4 bits (98), Expect = 0.001 Identities = 34/108 (31%), Positives = 51/108 (47%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G+++ L++ L G + + +G L A +G +LL A D + TPL Sbjct: 27 GNSQRLEQLLQQGLPPNLRNHKGDSLLMLASYHGHADTVRLLLAYKADPDLRNLAGQTPL 86 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 AA G V+LLL GA V + DGKT + +A + +Q EV L Sbjct: 87 AGAAFKGDLAMVELLLAGGADVEGASADGKTALMMAAMFNQAEVAASL 134
>ANR10_HUMAN (Q9NXR5) Ankyrin repeat domain-containing protein 10| Length = 420 Score = 51.2 bits (121), Expect = 3e-06 Identities = 28/81 (34%), Positives = 42/81 (51%) Frame = -3 Query: 562 HFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNL 383 H A G +C L++AGA ++ D TP+H AA G EC+ L+ +GA V L+N Sbjct: 97 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156 Query: 382 DGKTPIEVAKLNSQDEVVKLL 320 G T ++A+ E + L Sbjct: 157 SGLTAADIAQTQGFQECAQSL 177 Score = 49.3 bits (116), Expect = 1e-05 Identities = 28/92 (30%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = -3 Query: 592 EEDVEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTPLHYAAGYGRKECVDLLL 416 E+ G +H+A +G+L+C L+ AGA ++ + + TP H AA G +C+ L+ Sbjct: 53 EDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLI 112 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + GA + + +G+TPI A + E + L Sbjct: 113 QAGANINKPDCEGETPIHKAARSGSLECISAL 144 Score = 40.8 bits (94), Expect = 0.004 Identities = 25/76 (32%), Positives = 35/76 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + L + GAN ++ D EG +H A G L+C L+ GA VD + + T Sbjct: 103 GHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162 Query: 463 HYAAGYGRKECVDLLL 416 A G +EC LL Sbjct: 163 DIAQTQGFQECAQSLL 178
>AKR_ARATH (Q05753) Ankyrin repeat protein, chloroplast precursor (AKRP)| Length = 435 Score = 51.2 bits (121), Expect = 3e-06 Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 4/101 (3%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 AN D EG +H+A ++LL A ++A D++ TPLH A R + V Sbjct: 317 ANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVK 376 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQD----EVVKLLEQ 314 LLL GA + ++N DG TP+ + ++ EV+KLL++ Sbjct: 377 LLLIKGADIEVKNKDGLTPLGLCLYLGREIRTYEVMKLLKE 417 Score = 43.9 bits (102), Expect = 4e-04 Identities = 35/103 (33%), Positives = 45/103 (43%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 LK LD A DV G LH A + LL A LD T +HYA Sbjct: 280 LKHNLDINAT----DVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQ 335 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + LLL + A + Q+ DG TP+ VA + ++VKLL Sbjct: 336 TASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLL 378
>VB04_VACCV (P24769) Ankyrin repeat protein B4| Length = 558 Score = 51.2 bits (121), Expect = 3e-06 Identities = 35/113 (30%), Positives = 56/113 (49%), Gaps = 2/113 (1%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGY--GELKCAEILLEAGAAVDALDKNKNTPLH 461 E +K L+ G++ D++D G C + ++ EI LE A +D++D N+ TPLH Sbjct: 191 ELIKILLNNGSDVDKKDTYGNTPFILLCKHDINNVELFEICLE-NANIDSVDFNRYTPLH 249 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL 302 Y + + + V LL+ GA V +N G TP ++ + LE D L Sbjct: 250 YVSCRNKYDFVKLLISKGANVNARNRFGTTPFYCGIIHGISLIKLYLESDTEL 302
>VB04_VACCC (P21001) Ankyrin repeat protein B4| Length = 558 Score = 51.2 bits (121), Expect = 3e-06 Identities = 35/113 (30%), Positives = 56/113 (49%), Gaps = 2/113 (1%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGY--GELKCAEILLEAGAAVDALDKNKNTPLH 461 E +K L+ G++ D++D G C + ++ EI LE A +D++D N+ TPLH Sbjct: 191 ELIKILLNNGSDVDKKDTYGNTPFILLCKHDINNVELFEICLE-NANIDSVDFNRYTPLH 249 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL 302 Y + + + V LL+ GA V +N G TP ++ + LE D L Sbjct: 250 YVSCRNKYDFVKLLISKGANVNARNKFGTTPFYCGIIHGISLIKLYLESDTEL 302
>CENG2_MOUSE (Q8BXK8) Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like,| ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) Length = 857 Score = 50.8 bits (120), Expect = 3e-06 Identities = 25/58 (43%), Positives = 36/58 (62%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 +GR ALH AC G + A++L+ G V A D + NT L YA +EC+D+LL++G Sbjct: 768 DGRTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALAYARQASSQECIDVLLQYG 825
>ANKR7_HUMAN (Q92527) Ankyrin repeat domain-containing protein 7| (Testis-specific protein TSA806) Length = 201 Score = 50.8 bits (120), Expect = 3e-06 Identities = 30/71 (42%), Positives = 40/71 (56%) Frame = -3 Query: 532 CAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 CA ILL GA D D NT LHYA V+ LL++ A + +N DG TP+ VA Sbjct: 54 CATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAV 113 Query: 352 LNSQDEVVKLL 320 +N+ ++VK L Sbjct: 114 INNNPKMVKFL 124 Score = 41.6 bits (96), Expect = 0.002 Identities = 33/101 (32%), Positives = 48/101 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ D D+ LH+A L E LLE A ++A +K+ TPL A Sbjct: 59 LNFGADPDLRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNP 118 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 + V LL+ GA V + +T + +A +VKLL Q Sbjct: 119 KMVKFLLEKGADVNASDNYQRTALILAVSGEPPCLVKLLLQ 159 Score = 30.4 bits (67), Expect = 4.8 Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 1/83 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 ++K L+ A+ + ++ +G L A K + LLE GA V+A D + T L A Sbjct: 88 VEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVS 147 Query: 448 YGRKEC-VDLLLKHGAAVMLQNL 383 G C V LLL+ G + + + Sbjct: 148 -GEPPCLVKLLLQQGVELCYEGI 169
>YMV8_YEAST (Q04749) Hypothetical 47.1 kDa protein in NCA1-HMS1 intergenic| region Length = 426 Score = 50.8 bits (120), Expect = 3e-06 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 3/78 (3%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 GR +H AC +C +L+ GA + +D N +TPLH YG C+ +LL G Sbjct: 109 GRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVS 168 Query: 397 MLQNLDGK---TPIEVAK 353 + N+ K PI+VA+ Sbjct: 169 LDDNVRDKGNWKPIDVAQ 186 Score = 33.1 bits (74), Expect = 0.73 Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 1/88 (1%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAA-VDALDKNKNTPLHYAAGYGRKECVDLLLKHGA 404 +G +H A G + +LL+ ++ +N P+H A +C+ LL+ GA Sbjct: 74 KGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGA 133 Query: 403 AVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 + + + +G TP+ V +K+L Sbjct: 134 DLWVMDTNGDTPLHVCLEYGSISCMKML 161
>CMTA3_ARATH (Q8GSA7) Calmodulin-binding transcription activator 3| (Signal-responsive protein 1) (Ethylene-induced calmodulin-binding protein a) (EICBP.a) (Ethylene-induced calmodulin-binding protein 1) (EICBP1) Length = 1032 Score = 50.4 bits (119), Expect = 4e-06 Identities = 37/111 (33%), Positives = 52/111 (46%), Gaps = 6/111 (5%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 L+K +GG D G+ LHFA G E + AG +VD D N T LH+AA Sbjct: 645 LQKIAEGGKGPSVLDEGGQGVLHFAASLGYNWALEPTIIAGVSVDFRDVNGWTALHWAAF 704 Query: 448 YGRKECVDLLLKHGAA---VMLQNLD---GKTPIEVAKLNSQDEVVKLLEQ 314 +GR+ + L+ GAA + N D G TP ++A N + L + Sbjct: 705 FGRERIIGSLIALGAAPGTLTDPNPDFPSGSTPSDLAYANGHKGIAGYLSE 755 Score = 32.0 bits (71), Expect = 1.6 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 8/100 (8%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDAL-DKNK- 476 S+G L+ + G + D DV G ALH+A +G + L+ GAA L D N Sbjct: 671 SLGYNWALEPTIIAGVSVDFRDVNGWTALHWAAFFGRERIIGSLIALGAAPGTLTDPNPD 730 Query: 475 ----NTPLHYAAGYGRKECVDLLLKHG--AAVMLQNLDGK 374 +TP A G K L ++ A V L +L+ K Sbjct: 731 FPSGSTPSDLAYANGHKGIAGYLSEYALRAHVSLLSLNDK 770
>LITA_LATMA (Q02989) Alpha-latroinsectotoxin precursor (Alpha-LIT) (Fragment)| Length = 1411 Score = 50.4 bits (119), Expect = 4e-06 Identities = 28/88 (31%), Positives = 47/88 (53%), Gaps = 1/88 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 ++ GAN +++ G LHFA G G+ +LL GA + A D N P+H A G Sbjct: 790 VEKGANVNDKTNSGVTPLHFAAGLGKANIFRLLLSRGADIKAEDINSQMPIHEAVSNGHL 849 Query: 436 ECVDLLLKHGAAVM-LQNLDGKTPIEVA 356 E V +L++ ++M ++N+ + P +A Sbjct: 850 EIVRILIEKDPSLMNVKNIRNEYPFYLA 877 Score = 50.1 bits (118), Expect = 6e-06 Identities = 33/108 (30%), Positives = 53/108 (49%) Frame = -3 Query: 580 EGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA 401 +G ALH + L+E GA V+ + TPLH+AAG G+ LLL GA Sbjct: 769 KGFSALHLGIIGKNEEIPFFLVEKGANVNDKTNSGVTPLHFAAGLGKANIFRLLLSRGAD 828 Query: 400 VMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLIDPKTL 257 + ++++ + PI A N E+V++L + DP L++ K + Sbjct: 829 IKAEDINSQMPIHEAVSNGHLEIVRILIE--------KDPSLMNVKNI 868 Score = 43.5 bits (101), Expect = 5e-04 Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 2/101 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGA-AVDALDKNKNTPLHYAAGYGR 440 + GAN E GR A+H A G E+LL ++ DKN TPLH AA + Sbjct: 487 IQNGANVSETFELGRGAIHAAASAGNYDVGELLLNKDINLLEKADKNGYTPLHIAADSNK 546 Query: 439 KECVDLLLKHGAAVMLQ-NLDGKTPIEVAKLNSQDEVVKLL 320 + V L+ + A V ++ D TP+ +A +V + L Sbjct: 547 NDFVMFLIGNNADVNVRTKSDLFTPLHLAARRDLTDVTQTL 587 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 2/91 (2%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 G LH A L +++L GA ++ D N TPLHYAA G E VD LL Sbjct: 635 GLTPLHLATLQNNLSVSKLLAGKGAYLNDGDANGMTPLHYAAMTGNLEMVDFLLNQQYIN 694 Query: 397 MLQNLDGK--TPIEVAKLNSQDEVVKLLEQD 311 + K TP+ +A L +++V + L D Sbjct: 695 INAATKEKKWTPLHLAILFKKNDVAERLLSD 725 Score = 31.6 bits (70), Expect = 2.1 Identities = 23/90 (25%), Positives = 35/90 (38%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 +D G LH + A ++ A ++ K TPLH A LL Sbjct: 598 QDKSGFTPLHLSISSTSETAAILIRNTNAVINIKSKVGLTPLHLATLQNNLSVSKLLAGK 657 Query: 409 GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 GA + + +G TP+ A + E+V L Sbjct: 658 GAYLNDGDANGMTPLHYAAMTGNLEMVDFL 687 Score = 31.6 bits (70), Expect = 2.1 Identities = 18/60 (30%), Positives = 31/60 (51%) Frame = -3 Query: 499 VDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 ++A DK+ TPLH + + L+ A + +++ G TP+ +A L + V KLL Sbjct: 595 LNAQDKSGFTPLHLSISSTSETAAILIRNTNAVINIKSKVGLTPLHLATLQNNLSVSKLL 654 Score = 30.0 bits (66), Expect = 6.2 Identities = 21/78 (26%), Positives = 31/78 (39%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 AN +E D G LH GEL+ + L++ GA + + T A GR V Sbjct: 894 ANVNEVDHNGNTLLHLFSSTGELEVVQFLMQNGANFRLKNNERKTFFDLAIENGRLNIVA 953 Query: 424 LLLKHGAAVMLQNLDGKT 371 ++ + GKT Sbjct: 954 FAVEKNKVNLQAAHRGKT 971
>HOS4_YEAST (P40480) Protein HOS4| Length = 1083 Score = 50.4 bits (119), Expect = 4e-06 Identities = 33/97 (34%), Positives = 55/97 (56%), Gaps = 3/97 (3%) Frame = -3 Query: 643 GDAEGLKKALD-GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVD--ALDKNKN 473 G + +KK ++ GG + +++D G ALH A G ++ E+L+E GA V+ +++ + Sbjct: 341 GKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGD 400 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE 362 TPL A+ G + V LLK+GA ++N G T E Sbjct: 401 TPLIDASANGHLDVVKYLLKNGADPTIRNAKGLTAFE 437 Score = 32.0 bits (71), Expect = 1.6 Identities = 18/38 (47%), Positives = 21/38 (55%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 AL A G G L ++LLEAGA DK T L+YA Sbjct: 597 ALMVAVGRGHLGTVKLLLEAGADPTKRDKKGRTALYYA 634 Score = 30.4 bits (67), Expect = 4.8 Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 5/87 (5%) Frame = -3 Query: 553 CGYGELKCAEILLEAGAAVDALDK-NKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDG 377 CG+ ++ I L G V+ + NK + L A G G V LLL+ GA ++ G Sbjct: 570 CGHEDI--TSIFLAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLEAGADPTKRDKKG 627 Query: 376 KTPIEVAKLN----SQDEVVKLLEQDV 308 +T + AK + + E ++L+E + Sbjct: 628 RTALYYAKNSIMGITNSEEIQLIENAI 654
>V034_FOWPV (Q9J5G9) Putative ankyrin repeat protein FPV034| Length = 415 Score = 50.4 bits (119), Expect = 4e-06 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = -3 Query: 577 GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAV 398 GR +LH A + A +L+ GA VD+ D NTP+ AA + LLL +GA + Sbjct: 238 GRTSLHLAIKERNYEAAFVLINNGANVDSFDDVGNTPIFIAASLQDVRFMKLLLDNGADI 297 Query: 397 MLQNLDGKTPIEVAKLNSQDEVVK 326 ++N+ G+TP+ + EV + Sbjct: 298 NVRNVFGETPVNMVITGGSKEVTQ 321 Score = 40.8 bits (94), Expect = 0.004 Identities = 35/135 (25%), Positives = 64/135 (47%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 +D N + D G L +A ++ A+ILL+AG+ ++ KN LH A + K Sbjct: 64 IDKNFNINIADSVGYTLLRYAVEVDDVNIAKILLDAGSIIN---KNDYRLLHSAITHENK 120 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLIDPKTL 257 + ++LL HG + +++ G T + N+ ++V FL K +D +++ ++ Sbjct: 121 KMIELLCLHGININVKDDKGYTALYYTICNNNYDMV------CFLLEKNADISIVNKYSM 174 Query: 256 PCFWSLSGVMSWHGV 212 F S S +H V Sbjct: 175 LHFLSTSN--KYHNV 187
>NOTC3_HUMAN (Q9UM47) Neurogenic locus notch homolog protein 3 precursor (Notch 3)| [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain] Length = 2321 Score = 50.4 bits (119), Expect = 4e-06 Identities = 32/97 (32%), Positives = 49/97 (50%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A ++ LL+ GA D D + TPL AA G E Sbjct: 1930 ADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAK 1989 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLL H A + + + P +VA+ ++V+LL+Q Sbjct: 1990 LLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQ 2026 Score = 42.7 bits (99), Expect = 0.001 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 2/109 (1%) Frame = -3 Query: 640 DAEGLKKAL--DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 DA+G+ + L + + D +G AL A E L+ + A V+A+D+ + Sbjct: 1883 DAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSA 1942 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+AA E LLK+GA +Q+ +TP+ +A E KLL Sbjct: 1943 LHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLL 1991 Score = 40.0 bits (92), Expect = 0.006 Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 1/78 (1%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A Y A+ LL+AGA +A D + TPLH A + +L+++ Sbjct: 1836 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNR 1895 Query: 406 AAVM-LQNLDGKTPIEVA 356 + + + DG T + +A Sbjct: 1896 STDLDARMADGSTALILA 1913 Score = 35.0 bits (79), Expect = 0.19 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 1/68 (1%) Frame = -3 Query: 520 LLEAGAAVDA-LDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 L+ GA + A D+ T LH AA Y R + LL GA Q+ G+TP+ A Sbjct: 1824 LICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTAD 1883 Query: 343 QDEVVKLL 320 V ++L Sbjct: 1884 AQGVFQIL 1891
>NOTC3_RAT (Q9R172) Neurogenic locus notch homolog protein 3 precursor (Notch 3)| [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain] Length = 2319 Score = 50.4 bits (119), Expect = 4e-06 Identities = 32/97 (32%), Positives = 49/97 (50%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A ++ LL+ GA D D + TPL AA G E Sbjct: 1932 ADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAK 1991 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLL H A + + + P +VA+ ++V+LL+Q Sbjct: 1992 LLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQ 2028 Score = 42.7 bits (99), Expect = 0.001 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 2/109 (1%) Frame = -3 Query: 640 DAEGLKKAL--DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 DA+G+ + L + + D +G AL A E L+ + A V+A+D+ + Sbjct: 1885 DAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSA 1944 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+AA E LLK+GA +Q+ +TP+ +A E KLL Sbjct: 1945 LHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLL 1993 Score = 40.0 bits (92), Expect = 0.006 Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 1/78 (1%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A Y A+ LL+AGA +A D + TPLH A + +L+++ Sbjct: 1838 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNR 1897 Query: 406 AAVM-LQNLDGKTPIEVA 356 + + + DG T + +A Sbjct: 1898 STDLDARMADGSTALILA 1915 Score = 35.0 bits (79), Expect = 0.19 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 1/68 (1%) Frame = -3 Query: 520 LLEAGAAVDA-LDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 L+ GA + A D+ T LH AA Y R + LL GA Q+ G+TP+ A Sbjct: 1826 LICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTAD 1885 Query: 343 QDEVVKLL 320 V ++L Sbjct: 1886 AQGVFQIL 1893
>V231_FOWPV (Q9J504) Putative ankyrin repeat protein FPV231| Length = 256 Score = 50.1 bits (118), Expect = 6e-06 Identities = 29/88 (32%), Positives = 50/88 (56%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 +K L+ G + + D G ALH+A + ++LL +GA + ++ K+TPL++A Sbjct: 74 VKLLLNHGIDYNLRDNHGYTALHYAITLQNREITDMLLSSGADPNIMNNEKHTPLYHALL 133 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPI 365 Y R V+ L+ HGA + + + GKTP+ Sbjct: 134 Y-RSSNVESLILHGADINIVDDTGKTPL 160 Score = 47.0 bits (110), Expect = 5e-05 Identities = 30/96 (31%), Positives = 43/96 (44%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + D R LH A G + ++LL G + D + T LHYA +E Sbjct: 48 GADTNIVDKYNRSVLHKAIGNNNITSVKLLLNHGIDYNLRDNHGYTALHYAITLQNREIT 107 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 D+LL GA + N + TP+ A L V L+ Sbjct: 108 DMLLSSGADPNIMNNEKHTPLYHALLYRSSNVESLI 143 Score = 42.0 bits (97), Expect = 0.002 Identities = 30/102 (29%), Positives = 42/102 (41%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD GA D + E L+ A + + L GA + +DK + LH A G Sbjct: 9 KMLLDYGARIDSRNKEECLPLNHAIATNNKELTSLFLARGADTNIVDKYNRSVLHKAIGN 68 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 V LLL HG L++ G T + A E+ +L Sbjct: 69 NNITSVKLLLNHGIDYNLRDNHGYTALHYAITLQNREITDML 110
>ANKS1_HUMAN (Q92625) Ankyrin repeat and SAM domain-containing protein 1A (Odin)| Length = 1133 Score = 50.1 bits (118), Expect = 6e-06 Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 3/111 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANK---DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN 473 GDA+ ++ + G + +E++ + ALH A YG + ++LLE + Sbjct: 123 GDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFE 182 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPL AA YGR E V +LL ++ N TP+ +A N VV++L Sbjct: 183 TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL 233 Score = 45.4 bits (106), Expect = 1e-04 Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 3/103 (2%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G N + D G LH A G E+LL A + D PLH AA G + V Sbjct: 69 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 128 Query: 427 DLLLKHGAA---VMLQNLDGKTPIEVAKLNSQDEVVKLLEQDV 308 LL+ G + V QN D +T + A EVVK+L +++ Sbjct: 129 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEEL 171 Score = 40.4 bits (93), Expect = 0.005 Identities = 33/108 (30%), Positives = 46/108 (42%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E +K L+ + + + L A YG L+ ++LL A + + + K+TPL Sbjct: 159 GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPL 218 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G K V +LL G Q G E A D V LL Sbjct: 219 HLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILL 266
>NOTC3_MOUSE (Q61982) Neurogenic locus notch homolog protein 3 precursor (Notch 3)| [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain] Length = 2318 Score = 50.1 bits (118), Expect = 6e-06 Identities = 32/97 (32%), Positives = 49/97 (50%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A ++ LL+ GA D D + TPL AA G E Sbjct: 1931 ADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAK 1990 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LLL H A + + + P +VA+ ++V+LL+Q Sbjct: 1991 LLLDHLANREITDHLDRLPRDVAQERLHQDIVRLLDQ 2027 Score = 42.7 bits (99), Expect = 0.001 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 2/109 (1%) Frame = -3 Query: 640 DAEGLKKAL--DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 DA+G+ + L + + D +G AL A E L+ + A V+A+D+ + Sbjct: 1884 DAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSA 1943 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+AA E LLK+GA +Q+ +TP+ +A E KLL Sbjct: 1944 LHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLL 1992 Score = 40.0 bits (92), Expect = 0.006 Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 1/78 (1%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHG 407 D G ALH A Y A+ LL+AGA +A D + TPLH A + +L+++ Sbjct: 1837 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNR 1896 Query: 406 AAVM-LQNLDGKTPIEVA 356 + + + DG T + +A Sbjct: 1897 STDLDARMADGSTALILA 1914 Score = 35.0 bits (79), Expect = 0.19 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 1/68 (1%) Frame = -3 Query: 520 LLEAGAAVDA-LDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS 344 L+ GA + A D+ T LH AA Y R + LL GA Q+ G+TP+ A Sbjct: 1825 LICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTAD 1884 Query: 343 QDEVVKLL 320 V ++L Sbjct: 1885 AQGVFQIL 1892
>NOTC2_MOUSE (O35516) Neurogenic locus notch homolog protein 2 precursor (Notch 2)| (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] Length = 2470 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/97 (30%), Positives = 50/97 (51%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A ++ +LL+ GA D D + TPL AA G E Sbjct: 1966 ADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAK 2025 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 +LL H A + + + P +VA+ ++V+LL++ Sbjct: 2026 ILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDE 2062 Score = 41.2 bits (95), Expect = 0.003 Identities = 36/140 (25%), Positives = 56/140 (40%), Gaps = 34/140 (24%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE------------------ 512 A+ K+ LD GA+++ +D GR LH A +IL+ Sbjct: 1888 ADAAKRLLDAGADRNAQDNMGRCPLHAAVAGDAQGVFQILIRNRVTDLDARMNDGTTPLI 1947 Query: 511 ----------------AGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 A V+A+D + + LH+AA E LLLK+GA +Q+ Sbjct: 1948 LAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNK 2007 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 +TP+ +A E K+L Sbjct: 2008 EETPLFLAAREGSYEAAKIL 2027 Score = 40.4 bits (93), Expect = 0.005 Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 2/99 (2%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + + + D G ALH A Y A+ LL+AGA +A D PLH A + Sbjct: 1864 GASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADRNAQDNMGRCPLHAAVAGDAQGV 1923 Query: 430 VDLLLKHGAAVMLQNL-DGKTP-IEVAKLNSQDEVVKLL 320 +L+++ + + DG TP I A+L + V +L+ Sbjct: 1924 FQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELI 1962 Score = 31.2 bits (69), Expect = 2.8 Identities = 23/77 (29%), Positives = 32/77 (41%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +V + E L GAN+D +D + L A G + A+ILL+ A D D Sbjct: 1984 AVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRL 2043 Query: 469 PLHYAAGYGRKECVDLL 419 P A + V LL Sbjct: 2044 PRDVARDRMHHDIVRLL 2060
>EHMT2_HUMAN (Q96KQ7) Histone-lysine N-methyltransferase, H3 lysine-9 specific 3| (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a) Length = 1210 Score = 50.1 bits (118), Expect = 6e-06 Identities = 32/88 (36%), Positives = 45/88 (51%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYA 455 E ++ L GA+ D E LH+A G AE+LL A + A++ + +TPLH A Sbjct: 799 EVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKT 371 A +CV L L GA L+N +G T Sbjct: 859 ARESYHDCVLLFLSRGANPELRNKEGDT 886 Score = 47.8 bits (112), Expect = 3e-05 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L GAN + D + R L A L+ A +++ G V + +++ +T L Sbjct: 696 GSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCL 755 Query: 463 HYAAGYGRKECVDLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G E V LLL G V Q+ G TPI A + EV+++L Sbjct: 756 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 804 Score = 47.4 bits (111), Expect = 4e-05 Identities = 29/94 (30%), Positives = 44/94 (46%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + R LH A G ++ +LL+AGA ++A+DK + TPL A E Sbjct: 677 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARY 736 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +++ G V + DG T + A E+V LL Sbjct: 737 MVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770 Score = 39.7 bits (91), Expect = 0.008 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 7/93 (7%) Frame = -3 Query: 571 RALHFACGYGELKCAEILLEAGAAVDALDKN-------KNTPLHYAAGYGRKECVDLLLK 413 R L+ + GEL+ ++L +D LD N K TPLH AA G E +LL+ Sbjct: 652 RQLYLSVKQGELQKVILML-----LDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQ 706 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 GA + + +TP+ A +N+ EV + + Q Sbjct: 707 AGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ 739 Score = 39.3 bits (90), Expect = 0.010 Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 1/109 (0%) Frame = -3 Query: 646 VGDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +G+ E + L G + + +D G + +A + ++ +LL GA V D +N Sbjct: 761 IGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI 820 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 LH+A+ G ++LL + N G TP+ +A S + V L Sbjct: 821 CLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
>NOTC2_RAT (Q9QW30) Neurogenic locus notch homolog protein 2 precursor (Notch 2)| [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] Length = 2471 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/97 (30%), Positives = 50/97 (51%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A ++ +LL+ GA D D + TPL AA G E Sbjct: 1968 ADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAK 2027 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 +LL H A + + + P +VA+ ++V+LL++ Sbjct: 2028 ILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDE 2064 Score = 42.0 bits (97), Expect = 0.002 Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 2/99 (2%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + + + D G ALH A Y A+ LL+AGA +A D PLH A + Sbjct: 1866 GASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGV 1925 Query: 430 VDLLLKHGAAVMLQNL-DGKTP-IEVAKLNSQDEVVKLL 320 +L+++ + + DG TP I A+L + V +L+ Sbjct: 1926 FQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELI 1964 Score = 40.4 bits (93), Expect = 0.005 Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 34/140 (24%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE------------------ 512 A+ K+ LD GA+ + +D GR LH A +IL+ Sbjct: 1890 ADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLI 1949 Query: 511 ----------------AGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 A V+A+D + + LH+AA E LLLK+GA +Q+ Sbjct: 1950 LAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNK 2009 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 +TP+ +A E K+L Sbjct: 2010 EETPLFLAAREGSYEAAKIL 2029 Score = 31.2 bits (69), Expect = 2.8 Identities = 23/77 (29%), Positives = 32/77 (41%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +V + E L GAN+D +D + L A G + A+ILL+ A D D Sbjct: 1986 AVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRL 2045 Query: 469 PLHYAAGYGRKECVDLL 419 P A + V LL Sbjct: 2046 PRDVARDRMHHDIVRLL 2062
>NOTC2_HUMAN (Q04721) Neurogenic locus notch homolog protein 2 precursor (Notch 2)| (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] Length = 2471 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/97 (30%), Positives = 50/97 (51%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A ++ +LL+ GA D D + TPL AA G E Sbjct: 1968 ADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAK 2027 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 +LL H A + + + P +VA+ ++V+LL++ Sbjct: 2028 ILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDE 2064 Score = 42.0 bits (97), Expect = 0.002 Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 2/99 (2%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + + + D G ALH A Y A+ LL+AGA +A D PLH A + Sbjct: 1866 GASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGV 1925 Query: 430 VDLLLKHGAAVMLQNL-DGKTP-IEVAKLNSQDEVVKLL 320 +L+++ + + DG TP I A+L + V +L+ Sbjct: 1926 FQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELI 1964 Score = 40.4 bits (93), Expect = 0.005 Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 34/140 (24%) Frame = -3 Query: 637 AEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLE------------------ 512 A+ K+ LD GA+ + +D GR LH A +IL+ Sbjct: 1890 ADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLI 1949 Query: 511 ----------------AGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 A V+A+D + + LH+AA E LLLK+GA +Q+ Sbjct: 1950 LAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNK 2009 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 +TP+ +A E K+L Sbjct: 2010 EETPLFLAAREGSYEAAKIL 2029 Score = 31.2 bits (69), Expect = 2.8 Identities = 23/77 (29%), Positives = 32/77 (41%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +V + E L GAN+D +D + L A G + A+ILL+ A D D Sbjct: 1986 AVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRL 2045 Query: 469 PLHYAAGYGRKECVDLL 419 P A + V LL Sbjct: 2046 PRDVARDRMHHDIVRLL 2062
>POT15_HUMAN (Q6S5H4) Prostate, ovary, testis expressed protein on chromosome 15| Length = 581 Score = 50.1 bits (118), Expect = 6e-06 Identities = 30/92 (32%), Positives = 45/92 (48%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 ++ D + R ALH A G + ++LL+ ++ LD K T L A ECV +LL Sbjct: 167 NKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLL 226 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +HGA +Q+ G T + A N + K L Sbjct: 227 EHGADGNIQDEYGNTALHYAIYNEDKLMAKAL 258 Score = 47.0 bits (110), Expect = 5e-05 Identities = 36/108 (33%), Positives = 53/108 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G++E ++ LD + D + R AL A E +C +LLE GA + D+ NT L Sbjct: 184 GNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTAL 243 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 HYA K LL +GA + +N G TP+ + + +VVK L Sbjct: 244 HYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFL 291 Score = 39.3 bits (90), Expect = 0.010 Identities = 31/104 (29%), Positives = 53/104 (50%), Gaps = 1/104 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ GA+ + +D G ALH+A + A+ LL GA +++ +K TPL ++ Sbjct: 226 LEHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQ 285 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQDV 308 + V L+K A + + G+T + +A +V LLEQ+V Sbjct: 286 QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNV 329
>MIB2_CHICK (Q5ZIJ9) Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb| homolog 2) Length = 954 Score = 49.7 bits (117), Expect = 8e-06 Identities = 35/110 (31%), Positives = 55/110 (50%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 ++ +A +++ L +K + +GR AL A G L +ILL+A A V+ D+ +T Sbjct: 441 ALNNAAKVRELLQKYPDKVDNKNQGRTALQIASYQGHLDVVKILLQAHATVNLRDEEGDT 500 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LHYAA + + +L+ GA L N T + VA EVV+ L Sbjct: 501 ALHYAAFGNQADVARVLMAKGAGADLLNNAKCTALYVAVSQGFTEVVQAL 550 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 1/95 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN-TPLHYAAGYGRKECVDLL 419 D + +G ALH A + AEIL++ G + N+N TPLH A G V LL Sbjct: 626 DSKKEDGFTALHLAALNNHKEVAEILIKEGRCDVNVKNNRNQTPLHLAIIQGHVGLVQLL 685 Query: 418 LKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 + G+ V ++ DG T + +A L Q + L+E+ Sbjct: 686 VSEGSDVNAEDEDGDTAMHIA-LERQQLMSVLMEK 719 Score = 30.8 bits (68), Expect = 3.6 Identities = 31/140 (22%), Positives = 48/140 (34%), Gaps = 34/140 (24%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDAL-------- 488 G + +K L A + D EG ALH+A + A +L+ GA D L Sbjct: 476 GHLDVVKILLQAHATVNLRDEEGDTALHYAAFGNQADVARVLMAKGAGADLLNNAKCTAL 535 Query: 487 -------------------------DKNKNTPLHYAAGYGRKECVDLLLK-HGAAVMLQN 386 D + +TPLHYA K +++L + +QN Sbjct: 536 YVAVSQGFTEVVQALCELNCDVNLPDSHGDTPLHYAITADYKVIIEILTEVPNIDFTVQN 595 Query: 385 LDGKTPIEVAKLNSQDEVVK 326 G + + L +K Sbjct: 596 CQGFNLLHYSALKGNKLAIK 615
>BCL3_MOUSE (Q9Z2F6) B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3)| Length = 440 Score = 49.7 bits (117), Expect = 8e-06 Identities = 33/92 (35%), Positives = 45/92 (48%), Gaps = 1/92 (1%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALD-KNKNTPLHYAA 452 L A G + + + EG ALH A G + +LLE GA +DA+D K+ +PL +A Sbjct: 212 LDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAV 271 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 V LLL HGA V Q G + + A Sbjct: 272 ENNSLNMVQLLLLHGANVNAQMYSGSSALHSA 303 Score = 43.5 bits (101), Expect = 5e-04 Identities = 33/101 (32%), Positives = 53/101 (52%), Gaps = 5/101 (4%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEA--GAAVDALDKNKN--TPLHYAAGYGR 440 GA+ D G+ A+H AC + C + LL++ +VD +N T LH A G Sbjct: 182 GASPMALDRHGQTAIHLACEHRSPSCLQALLDSATSGSVDLEVRNYEGLTALHVAVNTGC 241 Query: 439 KECVDLLLKHGAAVMLQNL-DGKTPIEVAKLNSQDEVVKLL 320 +E V LLL+ GA + ++ G++P+ A N+ +V+LL Sbjct: 242 QEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNMVQLL 282 Score = 35.4 bits (80), Expect = 0.15 Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = -3 Query: 523 ILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAA----VMLQNLDGKTPIEVA 356 +L+ AGA+ ALD++ T +H A + C+ LL + + ++N +G T + VA Sbjct: 177 LLVTAGASPMALDRHGQTAIHLACEHRSPSCLQALLDSATSGSVDLEVRNYEGLTALHVA 236 Query: 355 -KLNSQDEVVKLLEQ 314 Q+ V+ LLE+ Sbjct: 237 VNTGCQEAVLLLLER 251 Score = 34.3 bits (77), Expect = 0.33 Identities = 33/120 (27%), Positives = 46/120 (38%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GAN + + G ALH A G G L L+ +GA + + +TPL A + + Sbjct: 286 GANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKNCHNDTPLMVARS---RRVI 342 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPVLIDPKTLPCF 248 D+L G A + P + E L + S S P L PK P F Sbjct: 343 DIL--RGKASRAASGSQPEPSPDQSATNSPESSSRLSSNGLQSSPSSSPSLSPPKDAPGF 400 Score = 29.6 bits (65), Expect = 8.1 Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 4/81 (4%) Frame = -3 Query: 586 DVEGRRALHFACGYGELKCAEILLE----AGAAVDALDKNKNTPLHYAAGYGRKECVDLL 419 D +G LH A + +L VD + + TPLH A + V LL Sbjct: 119 DEDGDTPLHIAVVQNNIAAVYRILSLFKLGSREVDVHNNLRQTPLHLAVITTLPDMVRLL 178 Query: 418 LKHGAAVMLQNLDGKTPIEVA 356 + GA+ M + G+T I +A Sbjct: 179 VTAGASPMALDRHGQTAIHLA 199
>V155_FOWPV (Q9J5A7) Putative ankyrin repeat protein FPV115| Length = 542 Score = 49.7 bits (117), Expect = 8e-06 Identities = 34/110 (30%), Positives = 59/110 (53%), Gaps = 3/110 (2%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEA---GAAVDALDKNKNT 470 +A+ L ++ G + + +D +G+ ALH+AC + C E + E GA ++ D+ T Sbjct: 231 NADMLLFLIEIGLDINTKDKKGKTALHYACN--SINCIETVKEIMKYGADINVKDREGLT 288 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH A YG + LL+++GA V ++ T + +A + E+VK L Sbjct: 289 PLHSACKYGDLKLSKLLIEYGADVKVKTT--STVLNLAVESGNVELVKFL 336 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/79 (36%), Positives = 45/79 (56%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S+ E +K+ + GA+ + +D EG LH AC YG+LK +++L+E GA D K +T Sbjct: 262 SINCIETVKEIMKYGADINVKDREGLTPLHSACKYGDLKLSKLLIEYGA--DVKVKTTST 319 Query: 469 PLHYAAGYGRKECVDLLLK 413 L+ A G E V L++ Sbjct: 320 VLNLAVESGNVELVKFLIE 338 Score = 41.2 bits (95), Expect = 0.003 Identities = 27/89 (30%), Positives = 44/89 (49%) Frame = -3 Query: 568 ALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 +L A ++ +LL+AG V++ K +TPLH G V LLL HGA + Sbjct: 350 SLSLAIRCKDINIVLLLLDAGMDVNS-SKCISTPLHLGVILGNSNIVKLLLDHGANINAI 408 Query: 388 NLDGKTPIEVAKLNSQDEVVKLLEQDVFL 302 + G+TP+E A + +L + + F+ Sbjct: 409 DKYGETPLEAANKRINIDYAELYKSNRFI 437 Score = 31.6 bits (70), Expect = 2.1 Identities = 20/50 (40%), Positives = 29/50 (58%) Frame = -3 Query: 541 ELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVML 392 EL ++LL GA ++ K+ PL++AA G E V+LLL +GA L Sbjct: 138 ELCIMDLLLRYGALPNSR-KDGLLPLYHAAAAGNTEMVELLLSYGAKTNL 186
>V026_FOWPV (Q9J5H5) Putative ankyrin repeat protein FPV026| Length = 436 Score = 49.7 bits (117), Expect = 8e-06 Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 6/111 (5%) Frame = -3 Query: 628 LKKALDGGANKDE-----EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKN-KNTP 467 +K L+ G N +E E++ LHFA G ILL AGA V+ +NTP Sbjct: 80 IKILLEYGVNVNENEYYEEELTCYSVLHFAVDIGNKDIVSILLYAGADVNNTRCYLRNTP 139 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 LH A + LLL GA + N +G PI++A + +++V +L Q Sbjct: 140 LHLAIQQKNTDIAKLLLDSGADQNITNENGNIPIQIAVTYNDEKMVNILLQ 190 Score = 43.9 bits (102), Expect = 4e-04 Identities = 23/82 (28%), Positives = 45/82 (54%) Frame = -3 Query: 565 LHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQN 386 LH A A++LL++GA + ++N N P+ A Y ++ V++LL++ + + + Sbjct: 140 LHLAIQQKNTDIAKLLLDSGADQNITNENGNIPIQIAVTYNDEKMVNILLQYSPNLEIAD 199 Query: 385 LDGKTPIEVAKLNSQDEVVKLL 320 +G+T + A L+ +V LL Sbjct: 200 YNGRTVLHNAVLDKNINIVSLL 221 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 1/103 (0%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K LD GA+++ + G + A Y + K ILL+ ++ D N T LH A Sbjct: 153 KLLLDSGADQNITNENGNIPIQIAVTYNDEKMVNILLQYSPNLEIADYNGRTVLHNAVLD 212 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDE-VVKLL 320 V LLL++GA V + ++G T I ++ +N D ++K+L Sbjct: 213 KNINIVSLLLENGALVDSKCIEGYT-ILLSSVNRTDPFIIKML 254
>AKT2_ARATH (Q38898) Potassium channel AKT2/3| Length = 802 Score = 49.7 bits (117), Expect = 8e-06 Identities = 30/101 (29%), Positives = 49/101 (48%) Frame = -3 Query: 622 KALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYG 443 KA G N D L G + LL+A + D D TPLH AA G Sbjct: 526 KAQQNGENTDVVPPNIASNLIAVVTTGNAALLDELLKAKLSPDITDSKGKTPLHVAASRG 585 Query: 442 RKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 ++CV +LLKHG + +++++G + + A ++ E+ ++L Sbjct: 586 YEDCVLVLLKHGCNIHIRDVNGNSALWEAIISKHYEIFRIL 626
>NOTC1_BRARE (P46530) Neurogenic locus notch homolog protein 1 precursor| Length = 2437 Score = 49.7 bits (117), Expect = 8e-06 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 2/117 (1%) Frame = -3 Query: 604 ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVD 425 A+ + D G+ ALH+A + A +LL+ GA D + + TPL AA G E Sbjct: 2007 ADPNAVDDSGKSALHWAAAVNNVDAAVVLLKNGANKDLQNNKEETPLFLAAREGSYETAK 2066 Query: 424 LLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SK--PSDPVLIDPKT 260 +LL H A + + + P ++A ++V+LLE+ + S P P L P T Sbjct: 2067 VLLDHLANRDIADHLDQLPRDIAHERMHHDIVRLLEEYNLVRSPPLPLSPPLCCPNT 2123 Score = 40.4 bits (93), Expect = 0.005 Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 2/86 (2%) Frame = -3 Query: 607 GAN-KDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 GAN ++ D G ALH A Y A+ LLE+ A + D TPLH A + Sbjct: 1905 GANLHNQTDRTGETALHLAARYARSDAAKRLLESCADANVQDNMGRTPLHAAVAADAQGV 1964 Query: 430 VDLLLKHGAAVMLQNL-DGKTPIEVA 356 +L+++ A + + DG TP+ +A Sbjct: 1965 FQILIRNRATDLDARMHDGTTPLILA 1990 Score = 38.9 bits (89), Expect = 0.013 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 2/109 (1%) Frame = -3 Query: 640 DAEGLKKAL--DGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 DA+G+ + L + + D +G L A E L+ A +A+D + + Sbjct: 1960 DAQGVFQILIRNRATDLDARMHDGTTPLILATRLAVEGMVEELINCHADPNAVDDSGKSA 2019 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LH+AA + +LLK+GA LQN +TP+ +A E K+L Sbjct: 2020 LHWAAAVNNVDAAVVLLKNGANKDLQNNKEETPLFLAAREGSYETAKVL 2068 Score = 32.3 bits (72), Expect = 1.3 Identities = 18/56 (32%), Positives = 27/56 (48%) Frame = -3 Query: 487 DKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 D+ T LH AA Y R + LL+ A +Q+ G+TP+ A V ++L Sbjct: 1913 DRTGETALHLAARYARSDAAKRLLESCADANVQDNMGRTPLHAAVAADAQGVFQIL 1968
>EHMT2_MOUSE (Q9Z148) Histone-lysine N-methyltransferase, H3 lysine-9 specific 3| (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a) Length = 1263 Score = 49.3 bits (116), Expect = 1e-05 Identities = 31/86 (36%), Positives = 44/86 (51%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 ++ L GA+ D E LH+A G AE+LL A + A++ + +TPLH AA Sbjct: 854 IRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAAR 913 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKT 371 +CV L L GA L+N +G T Sbjct: 914 ESYHDCVLLFLSRGANPELRNKEGDT 939 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/109 (32%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G E L GAN + D + R L A L+ A +++ G V + +++ +T L Sbjct: 749 GSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCL 808 Query: 463 HYAAGYGRKECVDLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H+AA G E V LLL G V Q+ G TPI A + +V+++L Sbjct: 809 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRML 857 Score = 46.2 bits (108), Expect = 8e-05 Identities = 29/94 (30%), Positives = 44/94 (46%) Frame = -3 Query: 601 NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDL 422 N + R LH A G ++ +LL+AGA ++A+DK + TPL A E Sbjct: 730 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARY 789 Query: 421 LLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +++ G V + DG T + A E+V LL Sbjct: 790 MVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 823 Score = 39.7 bits (91), Expect = 0.008 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 7/93 (7%) Frame = -3 Query: 571 RALHFACGYGELKCAEILLEAGAAVDALDKN-------KNTPLHYAAGYGRKECVDLLLK 413 R L+ + GEL+ ++L +D LD N K TPLH AA G E +LL+ Sbjct: 705 RQLYLSVKQGELQKVILML-----LDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQ 759 Query: 412 HGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 GA + + +TP+ A +N+ EV + + Q Sbjct: 760 AGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ 792 Score = 38.5 bits (88), Expect = 0.017 Identities = 28/109 (25%), Positives = 48/109 (44%), Gaps = 1/109 (0%) Frame = -3 Query: 646 VGDAEGLKKALDGG-ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 +G+ E + L G + + +D G + +A + + +LL GA V D +N Sbjct: 814 IGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENI 873 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKL 323 LH+A+ G ++LL + N G TP+ +A S + V L Sbjct: 874 CLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLL 922
>NOTC1_HUMAN (P46531) Neurogenic locus notch homolog protein 1 precursor (Notch 1)| (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain] Length = 2556 Score = 49.3 bits (116), Expect = 1e-05 Identities = 30/105 (28%), Positives = 54/105 (51%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 L+ ++ A+ + D G+ ALH+A + A +LL+ GA D + + TPL AA Sbjct: 2012 LEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAR 2071 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 G E +LL H A + + + P ++A+ ++V+LL++ Sbjct: 2072 EGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDE 2116 Score = 42.4 bits (98), Expect = 0.001 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + ++ D G ALH A Y A+ LLEA A + D TPLH A + Sbjct: 1918 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGV 1977 Query: 430 VDLLLKHGAAVMLQNL-DGKTPIEVA 356 +L+++ A + + DG TP+ +A Sbjct: 1978 FQILIRNRATDLDARMHDGTTPLILA 2003 Score = 33.9 bits (76), Expect = 0.43 Identities = 18/70 (25%), Positives = 33/70 (47%) Frame = -3 Query: 529 AEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKL 350 ++ + + + + D+ T LH AA Y R + LL+ A +Q+ G+TP+ A Sbjct: 1912 SDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVS 1971 Query: 349 NSQDEVVKLL 320 V ++L Sbjct: 1972 ADAQGVFQIL 1981
>NOTC1_RAT (Q07008) Neurogenic locus notch homolog protein 1 precursor (Notch 1)| [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain] Length = 2531 Score = 49.3 bits (116), Expect = 1e-05 Identities = 30/105 (28%), Positives = 54/105 (51%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 L+ ++ A+ + D G+ ALH+A + A +LL+ GA D + + TPL AA Sbjct: 2001 LEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAR 2060 Query: 448 YGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ 314 G E +LL H A + + + P ++A+ ++V+LL++ Sbjct: 2061 EGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDE 2105 Score = 43.1 bits (100), Expect = 7e-04 Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Frame = -3 Query: 610 GGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC 431 G + ++ D G ALH A Y A+ LLEA A + D TPLH A + Sbjct: 1907 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGV 1966 Query: 430 VDLLLKHGAAVMLQNL-DGKTPIEVA 356 +LL++ A + + DG TP+ +A Sbjct: 1967 FQILLRNRATDLDARMHDGTTPLILA 1992 Score = 33.9 bits (76), Expect = 0.43 Identities = 18/70 (25%), Positives = 33/70 (47%) Frame = -3 Query: 529 AEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKL 350 ++ + + + + D+ T LH AA Y R + LL+ A +Q+ G+TP+ A Sbjct: 1901 SDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVS 1960 Query: 349 NSQDEVVKLL 320 V ++L Sbjct: 1961 ADAQGVFQIL 1970
>ANR10_MOUSE (Q99LW0) Ankyrin repeat domain-containing protein 10| Length = 415 Score = 49.3 bits (116), Expect = 1e-05 Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 1/109 (0%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVE-GRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G E L + + GA+ + + H A G +C L++AGA ++ D TP Sbjct: 68 GKLECLMQLVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETP 127 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +H AA G EC+ L+ GA L+N G T ++A+ E + L Sbjct: 128 IHKAARSGSLECITALVGSGAHTDLRNASGLTAADIAQTQGFQECTQFL 176 Score = 40.4 bits (93), Expect = 0.005 Identities = 24/76 (31%), Positives = 35/76 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + L + GAN ++ D EG +H A G L+C L+ +GA D + + T Sbjct: 102 GHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNASGLTAA 161 Query: 463 HYAAGYGRKECVDLLL 416 A G +EC LL Sbjct: 162 DIAQTQGFQECTQFLL 177 Score = 35.0 bits (79), Expect = 0.19 Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 4/110 (3%) Frame = -3 Query: 631 GLKKALDGGANKDEEDVEGRRALHFACGYGELK--CAEILLEAGAAVDALDKNKN-TPLH 461 G A++ G + EE + R LH AC G+L C+ + A + A D TP+H Sbjct: 4 GAGVAVEAGFSS-EELLSLRFPLHRACRDGDLVALCSLLPHTPRAHLAAEDSFYGWTPVH 62 Query: 460 YAAGYGRKECVDLLLKHGAAVMLQNLD-GKTPIEVAKLNSQDEVVKLLEQ 314 +AA +G+ EC+ L++ GA++ + +TP +A + + L Q Sbjct: 63 WAAHFGKLECLMQLVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQ 112
>AKR1_SACBA (Q876L5) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 763 Score = 49.3 bits (116), Expect = 1e-05 Identities = 33/84 (39%), Positives = 44/84 (52%), Gaps = 4/84 (4%) Frame = -3 Query: 643 GDAEGLKKALDGG---ANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN 473 GD +K+ + G NKD + VE LH+A L + L+ GA V++ + Sbjct: 83 GDLATVKEMIHGKLLEVNKDGDSVEHITGLHWASINNRLSVVDFLVSQGADVNSRAGALH 142 Query: 472 -TPLHYAAGYGRKECVDLLLKHGA 404 TPLH+AA YG VD LLKHGA Sbjct: 143 ATPLHWAARYGYVYIVDFLLKHGA 166 Score = 40.8 bits (94), Expect = 0.004 Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 5/107 (4%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAA-----VDALDKNKNTPLHYAA 452 L GA+ D +G LH + + +L + + VD D T L +AA Sbjct: 162 LKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFSVVSKGLLDVDCQDPKGRTSLLWAA 221 Query: 451 GYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 G V +LLK GA + + + +G TP+ + Q V+K L QD Sbjct: 222 YQGDSLTVAVLLKFGANIKIADTEGFTPLHWGTVKGQPHVLKYLIQD 268 Score = 38.1 bits (87), Expect = 0.023 Identities = 23/81 (28%), Positives = 39/81 (48%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D +D +GR +L +A G+ +LL+ GA + D TPLH+ G+ + L+ Sbjct: 207 DCQDPKGRTSLLWAAYQGDSLTVAVLLKFGANIKIADTEGFTPLHWGTVKGQPHVLKYLI 266 Query: 415 KHGAAVMLQNLDGKTPIEVAK 353 + GA + GK +A+ Sbjct: 267 QDGADFFQKTDAGKDCFAIAQ 287
>POTE2_HUMAN (Q6S8J3) Prostate, ovary, testis expressed protein on chromosome 2| (Fragment) Length = 712 Score = 49.3 bits (116), Expect = 1e-05 Identities = 37/108 (34%), Positives = 53/108 (49%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G++E +K LD + D + R AL A E +CA +LLE G + D+ NT L Sbjct: 184 GNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTL 243 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 HYA K LL +GA + +N G TP+ + + +VVK L Sbjct: 244 HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFL 291 Score = 45.1 bits (105), Expect = 2e-04 Identities = 27/92 (29%), Positives = 43/92 (46%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 +++D + R ALH A G + ++LL+ ++ LD K T L A EC +LL Sbjct: 167 NKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLL 226 Query: 415 KHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +HG + + G T + A N + K L Sbjct: 227 EHGTDPNIPDEYGNTTLHYAIYNEDKLMAKAL 258 Score = 36.6 bits (83), Expect = 0.066 Identities = 28/104 (26%), Positives = 51/104 (49%), Gaps = 1/104 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L+ G + + D G LH+A + A+ LL GA +++ +K+ TPL ++ Sbjct: 226 LEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQ 285 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVK-LLEQDV 308 + V L+K A + + G+T + +A +V LLEQ++ Sbjct: 286 QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNI 329 Score = 34.3 bits (77), Expect = 0.33 Identities = 26/96 (27%), Positives = 44/96 (45%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + ++ G L + + + L++ A ++ALD+ T L A G V Sbjct: 262 GADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIV 321 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LLL+ V Q+L G+T E A + + +LL Sbjct: 322 SLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLL 357 Score = 32.3 bits (72), Expect = 1.3 Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Frame = -3 Query: 565 LHFACGYGELKCAE-ILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 LH A +G++ + I++ V+ DK K T LH A+ G E V LLL + + Sbjct: 143 LHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVL 202 Query: 388 NLDGKTPIEVAKLNSQDEVVKLL 320 + +T + A +DE +L Sbjct: 203 DNKKRTALIKAVQCQEDECALML 225
>V222_FOWPV (Q9J513) Putative ankyrin repeat protein FPV222| Length = 747 Score = 49.3 bits (116), Expect = 1e-05 Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 1/97 (1%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + + +GR LH AC Y + + L+E+G + +D TPL+YA Y R++ V Sbjct: 388 GASFNLTNRKGRTPLHTACKYNNTEAVKYLIESGCDTNIVDVMSFTPLNYAVYYEREDTV 447 Query: 427 DLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL+ G L + +PI A + ++K+L Sbjct: 448 KILLESGCVDPNLCDYKEVSPIIQAIKRNNKNIIKML 484 Score = 48.5 bits (114), Expect = 2e-05 Identities = 37/112 (33%), Positives = 50/112 (44%), Gaps = 4/112 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDE-EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 G E L+ L+ G N D E A+H+A + IL+ A D D+ +NTP Sbjct: 306 GSKELLEILLEYGCNPDICEKTTSTYAMHYAVIRKHYEMLNILIRYDAYTDVKDRQQNTP 365 Query: 466 LHYAAGYGRKEC---VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 HYA E + LL GA+ L N G+TP+ A + E VK L Sbjct: 366 AHYAVKLPISESCKYLKLLKLAGASFNLTNRKGRTPLHTACKYNNTEAVKYL 417 Score = 46.2 bits (108), Expect = 8e-05 Identities = 30/102 (29%), Positives = 48/102 (47%) Frame = -3 Query: 625 KKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGY 446 K + GA + +++ LH A G K E+LL GA +AL T LHY+ Sbjct: 121 KMLIQNGALVNMNNMKNITPLHIASSSGSYKMVELLLLHGANTNALTSYGETSLHYSVSS 180 Query: 445 GRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL+++G V + N D T + +A ++V+LL Sbjct: 181 NDLNISELLIENGTNVNVANKDSITALIIAVEIMSIDLVRLL 222 Score = 40.4 bits (93), Expect = 0.005 Identities = 28/91 (30%), Positives = 44/91 (48%) Frame = -3 Query: 535 KCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 K ++L AGA+ + ++ TPLH A Y E V L++ G + ++ TP+ A Sbjct: 379 KYLKLLKLAGASFNLTNRKGRTPLHTACKYNNTEAVKYLIESGCDTNIVDVMSFTPLNYA 438 Query: 355 KLNSQDEVVKLLEQDVFL*SKPSDPVLIDPK 263 +++ VK+L L S DP L D K Sbjct: 439 VYYEREDTVKIL-----LESGCVDPNLCDYK 464 Score = 39.7 bits (91), Expect = 0.008 Identities = 23/73 (31%), Positives = 40/73 (54%) Frame = -3 Query: 538 LKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEV 359 L+ A++L++ GA V+ + TPLH A+ G + V+LLL HGA G+T + Sbjct: 117 LEIAKMLIQNGALVNMNNMKNITPLHIASSSGSYKMVELLLLHGANTNALTSYGETSLHY 176 Query: 358 AKLNSQDEVVKLL 320 + ++ + +LL Sbjct: 177 SVSSNDLNISELL 189 Score = 37.0 bits (84), Expect = 0.051 Identities = 29/110 (26%), Positives = 51/110 (46%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNT 470 S G + ++ L GAN + G +LH++ +L +E+L+E G V+ +K+ T Sbjct: 146 SSGSYKMVELLLLHGANTNALTSYGETSLHYSVSSNDLNISELLIENGTNVNVANKDSIT 205 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 L A + V LLL GA L+ + + V + + ++K L Sbjct: 206 ALIIAVEIMSIDLVRLLLDKGADTNAIGLE-RFKLYVTETKQNNNILKYL 254
>POTE8_HUMAN (Q6S8J7) Prostate, ovary, testis expressed protein on chromosome 8| Length = 498 Score = 49.3 bits (116), Expect = 1e-05 Identities = 29/96 (30%), Positives = 42/96 (43%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 G ++ D + R ALH AC G + +LL+ + D K T L A EC Sbjct: 89 GPGINKRDKKKRTALHLACANGNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECA 148 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL+HG L ++ G T + A N + K L Sbjct: 149 LMLLQHGTDPNLPDMYGNTALHYAVYNEDKLMAKTL 184 Score = 45.1 bits (105), Expect = 2e-04 Identities = 35/108 (32%), Positives = 50/108 (46%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G++E + LD D + R AL A E +CA +LL+ G + D NT L Sbjct: 110 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL 169 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 HYA K LL +GA + +N G TP+ +A + +VK L Sbjct: 170 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFL 217 Score = 39.3 bits (90), Expect = 0.010 Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 1/85 (1%) Frame = -3 Query: 565 LHFACGYGELKCAE-ILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQ 389 LH A +GE+ A+ I++ G ++ DK K T LH A G E V LLL + + Sbjct: 69 LHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANGNSEVVSLLLDRQCQLHVF 128 Query: 388 NLDGKTPIEVAKLNSQDEVVKLLEQ 314 + +T + A +DE +L Q Sbjct: 129 DSKKRTALIKAVQCQEDECALMLLQ 153 Score = 38.9 bits (89), Expect = 0.013 Identities = 32/107 (29%), Positives = 51/107 (47%), Gaps = 3/107 (2%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G + + D+ G ALH+A + A+ LL GA +++ +K TPL A ++ Sbjct: 152 LQHGTDPNLPDMYGNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQ 211 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQ---DVF 305 V L+K A + + G+T + +A +V LL Q DVF Sbjct: 212 RMVKFLIKKKANLNALDRFGRTALILAVRCGSASIVSLLLQQNIDVF 258 Score = 32.0 bits (71), Expect = 1.6 Identities = 25/96 (26%), Positives = 45/96 (46%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA+ + ++ G L A + + + L++ A ++ALD+ T L A G V Sbjct: 188 GADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRFGRTALILAVRCGSASIV 247 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 LLL+ V Q++ G+T + A + + +LL Sbjct: 248 SLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLL 283
>AKR2_SACBA (Q876L4) Probable palmitoyltransferase AKR2 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR2) Length = 730 Score = 48.9 bits (115), Expect = 1e-05 Identities = 33/91 (36%), Positives = 49/91 (53%), Gaps = 2/91 (2%) Frame = -3 Query: 640 DAEGLKKALDGGANKDEED-VEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNTP 467 D + +K+ ++ GA +D ++ LH+AC A+ L+ GA V+ + T Sbjct: 45 DLKVVKEVVESGAIDINKDCIDELPGLHWACIKNRFSIAKFLIRRGANVNQTAGPERATA 104 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGK 374 LH+AA YG VDLLLKHGA L +DG+ Sbjct: 105 LHWAARYGHVYIVDLLLKHGANPTL--IDGQ 133 Score = 38.5 bits (88), Expect = 0.017 Identities = 30/102 (29%), Positives = 42/102 (41%), Gaps = 6/102 (5%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILL------EAGAAVDALDKNKNTPLHYA 455 L GAN D +G LHF+ + +L +D+ D N TPL +A Sbjct: 121 LKHGANPTLIDGQGLNILHFSVYSSNIMLVVYVLYFVVSNNNNVDIDSRDYNNRTPLLWA 180 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVV 329 A G V+LLLK GA V L + G + A + + Sbjct: 181 AYQGDFLTVELLLKFGATVALTDNRGFNALHCALVGGDQRAI 222
>PSDA_YEAST (P50086) Probable 26S proteasome regulatory subunit p28 (Proteasome| non-ATPase subunit 6) Length = 228 Score = 48.9 bits (115), Expect = 1e-05 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 3/113 (2%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDV--EGRRALHFACGYGELKCAEILLEAGAAVDALDKNK 476 SVG+ E +K D D + +G LH A G + ++ L+E GA+V DK Sbjct: 81 SVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFN 140 Query: 475 NTPLHYAAGYGRKECVDLLLKHG-AAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 PLH AA G + ++LL G +AV Q+ G TP+ A + LL Sbjct: 141 QIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193
>AKR1_GIBZE (Q4I8B6) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 702 Score = 48.9 bits (115), Expect = 1e-05 Identities = 33/93 (35%), Positives = 47/93 (50%), Gaps = 1/93 (1%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L G D D G AL +A G +C ++ L GA+V A D+ T LH+A G Sbjct: 149 LHQGIPVDVIDTFGHTALMWAAYKGFPQCVDLFLRWGASVHATDEQGFTALHWALVKGSP 208 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAK-LNSQ 341 C+ L+++GA + GKTP AK LN++ Sbjct: 209 GCILKLIEYGADRFAKTQTGKTPSVTAKELNTE 241 Score = 43.5 bits (101), Expect = 5e-04 Identities = 31/111 (27%), Positives = 54/111 (48%), Gaps = 2/111 (1%) Frame = -3 Query: 646 VGDAEGLKKALDGGA-NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALD-KNKN 473 VGD ++K + G + D EG LH+A + + L+E GA ++ ++ Sbjct: 38 VGDVPAMEKLFESGEYDATYHDDEGITPLHWAAINNQYAMCKFLIEHGAEINRKGGESIA 97 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TPL +AA V+LLL+HGA ++ + G + ++ N ++ LL Sbjct: 98 TPLQWAAQRCHYYTVNLLLQHGADPLVTDAQGYNTLHISTFNGNVLLLVLL 148
>AKR1_ASPOR (Q7Z8U2) Palmitoyltransferase akr1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein akr1) Length = 737 Score = 48.9 bits (115), Expect = 1e-05 Identities = 29/80 (36%), Positives = 41/80 (51%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D +G L +A G ++ L GA +A+D+ TPLH+A G CV L+ Sbjct: 191 DVVDQQGHTGLMWAAYKGYPALVDLFLRWGAHANAVDEGGLTPLHWALVKGSLPCVLKLI 250 Query: 415 KHGAAVMLQNLDGKTPIEVA 356 ++GA + DGKTP VA Sbjct: 251 EYGADKFAKTRDGKTPAVVA 270 Score = 43.1 bits (100), Expect = 7e-04 Identities = 35/101 (34%), Positives = 48/101 (47%), Gaps = 1/101 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ DV+G LH A G +LL VD +D+ +T L +AA G Sbjct: 151 LQRGADPLLTDVQGYNILHLATIDGNAFLLVLLLHQEIPVDVVDQQGHTGLMWAAYKGYP 210 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKL-NSQDEVVKLLE 317 VDL L+ GA + G TP+ A + S V+KL+E Sbjct: 211 ALVDLFLRWGAHANAVDEGGLTPLHWALVKGSLPCVLKLIE 251
>AKR1_CANGA (Q6FJ70) Palmitoyltransferase AKR1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR1) Length = 763 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/92 (34%), Positives = 47/92 (51%), Gaps = 3/92 (3%) Frame = -3 Query: 643 GDAEGLKKALDGGANK--DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDA-LDKNKN 473 GD E +++ + GG + D EG LH+A L + L+ GA V++ + Sbjct: 69 GDLEVVREMIHGGQVNVSSDADREGVTGLHWAAINNRLNVVDFLVREGANVESKAGALEA 128 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDG 377 TPLH+AA YG VD LL+HGA+ + G Sbjct: 129 TPLHWAARYGFVYVVDYLLQHGASATTTDKQG 160 Score = 37.0 bits (84), Expect = 0.051 Identities = 23/81 (28%), Positives = 38/81 (46%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D +GR AL +A G+ L++ A+V D+ TPLH+ G+ + L+ Sbjct: 192 DYVDPKGRTALLWAAYQGDSLTVAALIKFNASVKIADEGGFTPLHWGTVKGQPHVLKYLI 251 Query: 415 KHGAAVMLQNLDGKTPIEVAK 353 + GA + D K +A+ Sbjct: 252 QDGADFFQKTNDNKDCFVIAE 272 Score = 35.4 bits (80), Expect = 0.15 Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 2/72 (2%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKN--TPLHYAAGYGRKE 434 G N +E+D H AC G+L+ ++ G + D ++ T LH+AA R Sbjct: 48 GENGNEDDDPILSKYHNACQRGDLEVVREMIHGGQVNVSSDADREGVTGLHWAAINNRLN 107 Query: 433 CVDLLLKHGAAV 398 VD L++ GA V Sbjct: 108 VVDFLVREGANV 119
>ANFY1_MOUSE (Q810B6) Ankyrin repeat and FYVE domain-containing protein 1| (Ankyrin repeats hooked to a zinc finger motif) Length = 1169 Score = 48.9 bits (115), Expect = 1e-05 Identities = 23/55 (41%), Positives = 35/55 (63%) Frame = -3 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 ++ TPLH AA +G +E V LL+ GA V Q+ +G+TP+ VA N +++LL Sbjct: 768 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPVHVAISNQHSVIIQLL 822 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 1/81 (1%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 +EE +G+ LH A +G + + LLE GA V+A D TP+H A + LL+ Sbjct: 764 EEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPVHVAISNQHSVIIQLLI 823 Query: 415 KH-GAAVMLQNLDGKTPIEVA 356 H + +++ G TP A Sbjct: 824 SHPNIELSVRDRQGLTPFACA 844 Score = 40.4 bits (93), Expect = 0.005 Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 1/118 (0%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG 449 ++ L GA +E + ALH A +LLE G A+D+N N LH A Sbjct: 922 VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 981 Query: 448 YGRKECVDLLLKHGAA-VMLQNLDGKTPIEVAKLNSQDEVVKLLEQDVFL*SKPSDPV 278 +GR + LL NL G++P+ + ++ + D+FL P P+ Sbjct: 982 HGRLNNIRALLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF--DLFLECMPEYPL 1037 Score = 37.7 bits (86), Expect = 0.030 Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 3/113 (2%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILL-EAGAAVDALDKNKN 473 S G E ++ L+ GAN + +D EGR +H A ++L+ + D+ Sbjct: 779 SWGLEETVQCLLEFGANVNAQDAEGRTPVHVAISNQHSVIIQLLISHPNIELSVRDRQGL 838 Query: 472 TPLHYAAGYGRKECVDLLLKH--GAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 TP A Y + + +LK GAA + N G+ + VA NS E V L Sbjct: 839 TPFACAMTYKNNKAAEAILKRESGAAEQVDN-KGRNFLHVAVQNSDIESVLFL 890 Score = 36.6 bits (83), Expect = 0.066 Identities = 25/100 (25%), Positives = 43/100 (43%) Frame = -3 Query: 619 ALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGR 440 ++ N +D LH A G LL AGA V+ L K++ T LH AA Sbjct: 892 SVQANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 951 Query: 439 KECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 +LL++G + +G + +A ++ + ++ L Sbjct: 952 PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRAL 991 Score = 35.0 bits (79), Expect = 0.19 Identities = 24/99 (24%), Positives = 46/99 (46%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ ++ +G+ LH A + K A LLE A ++ ++ T L A + Sbjct: 609 LGSGASINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIKHQLP 668 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 VD + GA + + + G P+ +A ++ +++ L Sbjct: 669 LVVDAICTRGADMSVPDEKGNPPLWLALASNLEDIASTL 707 Score = 30.4 bits (67), Expect = 4.8 Identities = 21/78 (26%), Positives = 37/78 (47%) Frame = -3 Query: 589 EDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKH 410 +D + L A G A LL +GA+++ + T LH A + LL+H Sbjct: 585 KDSRDQTVLGLALWTGMHTIAAQLLGSGASINDTMSDGQTLLHMAIQRQDSKSALFLLEH 644 Query: 409 GAAVMLQNLDGKTPIEVA 356 A + ++ DG+T +++A Sbjct: 645 QADINVRTQDGETALQLA 662
>ASZ1_CARPS (Q2QLC6) Ankyrin repeat, SAM and basic leucine zipper| domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) Length = 475 Score = 48.5 bits (114), Expect = 2e-05 Identities = 41/117 (35%), Positives = 60/117 (51%), Gaps = 6/117 (5%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFAC---GYGE--LKCAEILLEAGAAVDALD 485 SV + E ++ LD GAN + D + + L C G E +KC E+LL A + Sbjct: 88 SVSNVELVRVLLDRGANANF-DKDKQTILITTCSSRGSEEQIVKCVELLLSRNADPNVPC 146 Query: 484 KNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIE-VAKLNSQDEVVKLLE 317 + TP+ YAA G + V LL+ HGA V Q+ G T + A+ ++ V+KLLE Sbjct: 147 RRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDESGYTALTWAARQGHKNVVLKLLE 203 Score = 46.6 bits (109), Expect = 6e-05 Identities = 30/80 (37%), Positives = 41/80 (51%) Frame = -3 Query: 559 FACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLLKHGAAVMLQNLD 380 +A G + +L+ GA V+ D++ T L +AA G K V LL+ GA MLQ D Sbjct: 155 YAARDGHPQVVALLVAHGAEVNTQDESGYTALTWAARQGHKNVVLKLLELGADKMLQTKD 214 Query: 379 GKTPIEVAKLNSQDEVVKLL 320 G P E+AK E+ LL Sbjct: 215 GNIPSEIAKRYKHLEIFSLL 234 Score = 37.0 bits (84), Expect = 0.051 Identities = 37/142 (26%), Positives = 67/142 (47%), Gaps = 2/142 (1%) Frame = -3 Query: 646 VGDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTP 467 +G + + L G +E++ ++AL G++ + LL +G +VD+ + TP Sbjct: 27 IGYLDRASQKLKGVLPTEEKNETFKKALTT----GDISLVQELLNSGISVDSSFRYGWTP 82 Query: 466 LHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI--EVAKLNSQDEVVKLLEQDVFL*SK 293 L YAA E V +LL GA D +T + + S++++VK +E L S+ Sbjct: 83 LMYAASVSNVELVRVLLDRGANANFDK-DKQTILITTCSSRGSEEQIVKCVE---LLLSR 138 Query: 292 PSDPVLIDPKTLPCFWSLSGVM 227 +DP +PC ++ +M Sbjct: 139 NADP------NVPCRRLMTPIM 154 Score = 30.8 bits (68), Expect = 3.6 Identities = 29/99 (29%), Positives = 40/99 (40%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECV 428 GA + +D G AL +A G LLE GA K+ N P A Y E Sbjct: 172 GAEVNTQDESGYTALTWAARQGHKNVVLKLLELGADKMLQTKDGNIPSEIAKRYKHLEIF 231 Query: 427 DLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLLEQD 311 LL ++ L L GK + + ++ + KLL D Sbjct: 232 SLL-----SLSLNPLKGK----LQQQTKEETICKLLATD 261
>AKR2_YEAST (Q12013) Probable palmitoyltransferase AKR2 (EC 2.3.1.-) (Ankyrin| repeat-containing protein AKR2) Length = 749 Score = 48.5 bits (114), Expect = 2e-05 Identities = 34/91 (37%), Positives = 46/91 (50%), Gaps = 2/91 (2%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEED-VEGRRALHFACGYGELKCAEILLEAGAAVD-ALDKNKNT 470 GD + +K ++ GA D ++ LH+AC A+ LL GA + A T Sbjct: 61 GDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGAT 120 Query: 469 PLHYAAGYGRKECVDLLLKHGAAVMLQNLDG 377 LH+AA YG VDLLLKHGA L++ G Sbjct: 121 ALHWAARYGNIYIVDLLLKHGADPTLKDEQG 151 Score = 36.2 bits (82), Expect = 0.087 Identities = 27/102 (26%), Positives = 43/102 (42%), Gaps = 6/102 (5%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILL------EAGAAVDALDKNKNTPLHYA 455 L GA+ +D +G +HF+ + +L +D+ D N TPL +A Sbjct: 138 LKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWA 197 Query: 454 AGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVV 329 A G V+LLLK G+ V + G + A + V+ Sbjct: 198 AYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVI 239
>V232_FOWPV (Q9J503) Putative ankyrin repeat protein FPV232| Length = 482 Score = 48.5 bits (114), Expect = 2e-05 Identities = 31/96 (32%), Positives = 53/96 (55%), Gaps = 1/96 (1%) Frame = -3 Query: 640 DAEGLKKALDGGAN-KDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 D + +K L GA+ K + + + + ALH+A K AE LL GA V++ D N+P+ Sbjct: 145 DTKIIKLLLAYGADTKIKTEDKLKTALHYASTNKNYKLAEYLLIYGAEVNSPDIGNNSPM 204 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H A + ++ V +LL++G+ N G TP+ ++ Sbjct: 205 HEAVRHRNEDVVKILLQYGSNTDHMNSCGTTPLHIS 240 Score = 40.0 bits (92), Expect = 0.006 Identities = 28/102 (27%), Positives = 53/102 (51%), Gaps = 5/102 (4%) Frame = -3 Query: 607 GANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAG----YGR 440 GA + D+ +H A + +ILL+ G+ D ++ TPLH + G Sbjct: 190 GAEVNSPDIGNNSPMHEAVRHRNEDVVKILLQYGSNTDHMNSCGTTPLHISVGRVLNRNN 249 Query: 439 KECVDLLLKHGAAVMLQ-NLDGKTPIEVAKLNSQDEVVKLLE 317 + +LL+HG +V +Q ++ G T + ++ ++S+D++ LLE Sbjct: 250 YSILKILLEHGTSVNIQSSILGFTALHLS-IHSEDKLNLLLE 290 Score = 35.4 bits (80), Expect = 0.15 Identities = 23/77 (29%), Positives = 40/77 (51%), Gaps = 1/77 (1%) Frame = -3 Query: 541 ELKCAEILLEAGAAVDALDKNK-NTPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPI 365 + K ++LL GA ++K T LHYA+ + + LL +GA V ++ +P+ Sbjct: 145 DTKIIKLLLAYGADTKIKTEDKLKTALHYASTNKNYKLAEYLLIYGAEVNSPDIGNNSPM 204 Query: 364 EVAKLNSQDEVVKLLEQ 314 A + ++VVK+L Q Sbjct: 205 HEAVRHRNEDVVKILLQ 221 Score = 31.2 bits (69), Expect = 2.8 Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 5/96 (5%) Frame = -3 Query: 628 LKKALDGGANKDEEDVEGRRALHFACGY----GELKCAEILLEAGAAVDALDKNKN-TPL 464 +K L G+N D + G LH + G +ILLE G +V+ T L Sbjct: 216 VKILLQYGSNTDHMNSCGTTPLHISVGRVLNRNNYSILKILLEHGTSVNIQSSILGFTAL 275 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVA 356 H + K ++LLL++GA + N + +TP+ +A Sbjct: 276 HLSIHSEDK--LNLLLEYGADPNILNFEKETPLSMA 309
>FEM1_CAEEL (P17221) Sex-determining protein fem-1 (Feminization of XX and XO| animals protein 1) Length = 656 Score = 48.5 bits (114), Expect = 2e-05 Identities = 34/108 (31%), Positives = 56/108 (51%) Frame = -3 Query: 643 GDAEGLKKALDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPL 464 G + +K L+ GA+ + G L A ++ E LL+ G V+ + NT L Sbjct: 134 GHLDIVKYLLEKGADPHIPNRHGHTCLMIASYRNKVGIVEELLKTGIDVNKKTERGNTAL 193 Query: 463 HYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDEVVKLL 320 H AA G E V +LLKHG +V+++++ G P+ A L+ +V+ +L Sbjct: 194 HDAAESGNVEVVKILLKHG-SVLMKDIQGVDPLMGAALSGFLDVLNVL 240 Score = 33.9 bits (76), Expect = 0.43 Identities = 23/60 (38%), Positives = 29/60 (48%), Gaps = 2/60 (3%) Frame = -3 Query: 526 EILLEAGAAVDALDKNKNTPLH--YAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAK 353 E LLE V+A DKN +TP+H A RK V LL G + +N G + V K Sbjct: 542 EQLLELDLDVNATDKNNDTPMHILLRAREFRKSLVRALLVRGTWLFARNRHGDVVLNVMK 601
>AKR1_EMENI (Q5B0V6) Palmitoyltransferase akr1 (EC 2.3.1.-) (Ankyrin| repeat-containing protein akr1) Length = 737 Score = 48.5 bits (114), Expect = 2e-05 Identities = 29/81 (35%), Positives = 40/81 (49%) Frame = -3 Query: 595 DEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKECVDLLL 416 D D +G L +A G C ++ L GA +A+D PLH+A G CV +L Sbjct: 192 DVVDQQGHTGLMWAAYKGYPACVDLFLRWGANPNAVDDGGLAPLHWALVKGSLPCVLKIL 251 Query: 415 KHGAAVMLQNLDGKTPIEVAK 353 ++GA DGKTP VA+ Sbjct: 252 EYGADRFATTTDGKTPALVAQ 272 Score = 43.5 bits (101), Expect = 5e-04 Identities = 35/101 (34%), Positives = 48/101 (47%), Gaps = 1/101 (0%) Frame = -3 Query: 616 LDGGANKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRK 437 L GA+ DV+G LH A G +LL VD +D+ +T L +AA G Sbjct: 152 LQYGADPLLTDVQGYNILHLATIDGNAFLLVLLLHQEIPVDVVDQQGHTGLMWAAYKGYP 211 Query: 436 ECVDLLLKHGAAVMLQNLDGKTPIEVAKL-NSQDEVVKLLE 317 CVDL L+ GA + G P+ A + S V+K+LE Sbjct: 212 ACVDLFLRWGANPNAVDDGGLAPLHWALVKGSLPCVLKILE 252 Score = 37.0 bits (84), Expect = 0.051 Identities = 31/116 (26%), Positives = 58/116 (50%), Gaps = 3/116 (2%) Frame = -3 Query: 646 VGDAEGLKKALDGGA-NKDEEDVEGRRALHFACGYGELKCAEILLEAGAAVDALD-KNKN 473 +G+ ++K D + D EG LH+A + + L+++GA V+A ++ Sbjct: 74 IGEVSVMQKLFDEKKFTANYSDEEGITPLHWAAINNQYAMCKFLIDSGADVNAKGGESVA 133 Query: 472 TPLHYAAGYGRKECVDLLLKHGAAVMLQNLDGKTPIEVAKLNSQD-EVVKLLEQDV 308 TP +AA V LLL++GA +L ++ G + +A ++ +V LL Q++ Sbjct: 134 TPAMWAAQRCHYYIVHLLLQYGADPLLTDVQGYNILHLATIDGNAFLLVLLLHQEI 189
>YL088_MIMIV (Q5UPF8) Putative ankyrin repeat protein L88| Length = 879 Score = 48.5 bits (114), Expect = 2e-05 Identities = 36/117 (30%), Positives = 58/117 (49%), Gaps = 7/117 (5%) Frame = -3 Query: 649 SVGDAEGLKKALDGGANKDEEDVEGRRALHFACGY--GELKCAEILLEAGAAVDALDKNK 476 S+ E ++ ++ GAN + + + R L +AC Y ++LL+ GA ++ D Sbjct: 259 SINSVEVVEILINRGANIEARNEKLRTPLMYACKYSHNNTSVIKLLLDKGANIETTDLRN 318 Query: 475 NTPLHYAAGYGRK-ECVDLLLKHGAAVMLQNLDGKTPIEVAKLNS----QDEVVKLL 320 NT L A+ Y E + LLL GA + N +G + +A +NS E+VKLL Sbjct: 319 NTALILASTYSSSVEPIKLLLDKGANINHTNDEGCNALNLACINSSYNNNSEIVKLL 375 Score = 42.7 bits (99), Expect = 0.001 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 7/112 (6%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFACGYG----ELKCAEILLEAGAAVDALDKNKNTP 467 E ++ L+ GA+ + D +G L A Y ++ EIL+ GA ++A ++ TP Sbjct: 227 ELIELLLNRGADIEAVDYKGLTCLMIASKYAGSINSVEVVEILINRGANIEARNEKLRTP 286 Query: 466 LHYAAGYGRK--ECVDLLLKHGAAVMLQNLDGKTPIEVAK-LNSQDEVVKLL 320 L YA Y + LLL GA + +L T + +A +S E +KLL Sbjct: 287 LMYACKYSHNNTSVIKLLLDKGANIETTDLRNNTALILASTYSSSVEPIKLL 338 Score = 35.8 bits (81), Expect = 0.11 Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 13/105 (12%) Frame = -3 Query: 595 DEEDVEGRRALHFA---CG-YGELKCAEILLEAGAAVDALDKNKNTPLHYAAGYGRKEC- 431 ++++ +G AL A CG + K ILLE GA + + TPL +A+ + + C Sbjct: 58 NQKNKKGYTALSIAVRNCGNWCSYKTVRILLEKGAKTNIKNNEGITPLIFAS-FNSRFCE 116 Query: 430 ----VDLLLKHGAAVMLQNLDGKTPIEVAKLNSQDE----VVKLL 320 ++LLLK+GA + ++ +G T + A NS VKLL Sbjct: 117 GFNVINLLLKYGADINARDNNGYTALMNASSNSNSSSTYTTVKLL 161 Score = 33.1 bits (74), Expect = 0.73 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 7/97 (7%) Frame = -3 Query: 634 EGLKKALDGGANKDEEDVEGRRALHFAC---GY-GELKCAEILLEAGAAVDALDKNKNTP 467 E +K LD GAN + + EG AL+ AC Y + ++L++ G+ ++ +D + Sbjct: 333 EPIKLLLDKGANINHTNDEGCNALNLACINSSYNNNSEIVKLLIDRGSNINNMDSERTIL 392 Query: 466 LHYAAGYGRKECVD---LLLKHGAAVMLQNLDGKTPI 365 G+ +D +LL + A + N +G T + Sbjct: 393 TSTCEFIGKGSNIDTVKILLDNNADPNIPNTNGNTTL 429 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 93,923,047 Number of Sequences: 219361 Number of extensions: 1938978 Number of successful extensions: 7401 Number of sequences better than 10.0: 462 Number of HSP's better than 10.0 without gapping: 5592 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7074 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6143359464 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
