>DCNL4_BRARE (Q5RHX6) DCN1-like protein 4 (Defective in cullin neddylation|
           protein 1-like protein 4) (DCUN1 domain-containing
           protein 4)
          Length = 280

 Score = 73.9 bits (180), Expect = 8e-14
 Identities = 39/73 (53%), Positives = 47/73 (64%)
 Frame = -1

Query: 401 TANIMLELLLSERWTLXXXXXXXXXXXXSCRVLNRDQWNNVLXFSRSILPDLSNYDFDGA 222
           TA  ML LLL + W L              +V+N+DQW NVL FSR+I  DLSNYD DGA
Sbjct: 204 TAKCMLGLLLGKTWPLFPVFNQFLEQSKY-KVINKDQWCNVLEFSRTINLDLSNYDEDGA 262

Query: 221 WPVLIDDFVEFVK 183
           WPVL+D+FVE+ K
Sbjct: 263 WPVLLDEFVEWYK 275

>DCNL4_MOUSE (Q8CCA0) DCN1-like protein 4 (Defective in cullin neddylation|
           protein 1-like protein 4) (DCUN1 domain-containing
           protein 4)
          Length = 292

 Score = 73.6 bits (179), Expect = 1e-13
 Identities = 39/73 (53%), Positives = 47/73 (64%)
 Frame = -1

Query: 401 TANIMLELLLSERWTLXXXXXXXXXXXXSCRVLNRDQWNNVLXFSRSILPDLSNYDFDGA 222
           TA  ML LLL + W L              +V+N+DQW NVL FSR+I  DLSNYD DGA
Sbjct: 216 TAKCMLGLLLGKIWPLFPVFHQFLEQSKY-KVINKDQWCNVLEFSRTISLDLSNYDEDGA 274

Query: 221 WPVLIDDFVEFVK 183
           WPVL+D+FVE+ K
Sbjct: 275 WPVLLDEFVEWYK 287

>DCNL4_HUMAN (Q92564) DCN1-like protein 4 (Defective in cullin neddylation|
           protein 1-like protein 4) (DCUN1 domain-containing
           protein 4)
          Length = 292

 Score = 73.2 bits (178), Expect = 1e-13
 Identities = 39/73 (53%), Positives = 47/73 (64%)
 Frame = -1

Query: 401 TANIMLELLLSERWTLXXXXXXXXXXXXSCRVLNRDQWNNVLXFSRSILPDLSNYDFDGA 222
           TA  ML LLL + W L              +V+N+DQW NVL FSR+I  DLSNYD DGA
Sbjct: 216 TAKCMLGLLLGKIWPLFPVFHQFLEQSKY-KVINKDQWCNVLEFSRTINLDLSNYDEDGA 274

Query: 221 WPVLIDDFVEFVK 183
           WPVL+D+FVE+ K
Sbjct: 275 WPVLLDEFVEWYK 287

>DCNL1_MOUSE (Q9QZ73) DCN1-like protein 1 (Defective in cullin neddylation|
           protein 1-like protein 1) (DCUN1 domain-containing
           protein 1) (Testis-specific protein 3)
          Length = 259

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 26/43 (60%), Positives = 32/43 (74%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R + +D WN +L FS  I  D+SNYD +GAWPVLIDDFVEF +
Sbjct: 206 RSIPKDTWNLLLDFSSMIADDMSNYDEEGAWPVLIDDFVEFAR 248

>DCNL1_HUMAN (Q96GG9) DCN1-like protein 1 (Defective in cullin neddylation|
           protein 1-like protein 1) (DCUN1 domain-containing
           protein 1) (Squamous cell carcinoma-related oncogene)
          Length = 259

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 26/43 (60%), Positives = 32/43 (74%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R + +D WN +L FS  I  D+SNYD +GAWPVLIDDFVEF +
Sbjct: 206 RSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFAR 248

>DCNL1_CHICK (Q5ZKU1) DCN1-like protein 1 (Defective in cullin neddylation|
           protein 1-like protein 1) (DCUN1 domain-containing
           protein 1)
          Length = 259

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 26/43 (60%), Positives = 32/43 (74%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R + +D WN +L FS  I  D+SNYD +GAWPVLIDDFVEF +
Sbjct: 206 RSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFAR 248

>DCNL2_MOUSE (Q8BZJ7) DCN1-like protein 2 (Defective in cullin neddylation|
           protein 2-like protein 2) (DCUN1 domain-containing
           protein 2)
          Length = 258

 Score = 59.3 bits (142), Expect = 2e-09
 Identities = 26/43 (60%), Positives = 31/43 (72%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R + RD WN +L F   I  DLSNYD +GAWPVLIDDFVE+ +
Sbjct: 205 RSIPRDTWNLLLDFGNMIADDLSNYDEEGAWPVLIDDFVEYAR 247

>DCNL2_HUMAN (Q6PH85) DCN1-like protein 2 (Defective in cullin neddylation|
           protein 2-like protein 2) (DCUN1 domain-containing
           protein 2)
          Length = 259

 Score = 58.5 bits (140), Expect = 4e-09
 Identities = 25/43 (58%), Positives = 31/43 (72%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R + RD WN +L F   I  D+SNYD +GAWPVLIDDFVE+ +
Sbjct: 206 RSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLIDDFVEYAR 248

>DCN1L_DROME (Q9VUQ8) DCN1-like protein (Defective in cullin neddylation protein|
           1-like protein)
          Length = 288

 Score = 55.8 bits (133), Expect = 2e-08
 Identities = 24/41 (58%), Positives = 32/41 (78%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEF 189
           R ++RD WN +L F+ +I   +SNYD +GAWPVLIDDFVE+
Sbjct: 202 RAISRDTWNLLLDFATNIDDRMSNYDSEGAWPVLIDDFVEW 242

>DCN1_USTMA (Q4PF67) Defective in cullin neddylation protein 1|
          Length = 319

 Score = 51.6 bits (122), Expect = 4e-07
 Identities = 21/43 (48%), Positives = 30/43 (69%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R +++D W   L F++ I  D SN+DFD AWP +IDDFV +V+
Sbjct: 265 RAVSKDTWMQFLDFTKEINSDFSNHDFDAAWPSIIDDFVLWVR 307

>DCN1_CRYNE (Q5KHV1) Defective in cullin neddylation protein 1|
          Length = 279

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 20/43 (46%), Positives = 30/43 (69%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           + +++D W  ++ F+R I  D   YD DGAWP +IDDFVE+V+
Sbjct: 231 KAVSKDTWALLVDFARGIDKDFKEYDEDGAWPSMIDDFVEYVR 273

>DCN1_CAEEL (Q9U3C8) Defective in cullin neddylation protein 1|
          Length = 295

 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 21/41 (51%), Positives = 28/41 (68%)
 Frame = -1

Query: 305 LNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           ++RD WN    F     PDLS+YD +GAWPVLID FV++ +
Sbjct: 232 ISRDTWNLFWDFILLSKPDLSDYDDEGAWPVLIDQFVDYCR 272

>DCN1_SCHPO (Q8WZK4) Defective in cullin neddylation protein 1|
          Length = 251

 Score = 48.1 bits (113), Expect = 5e-06
 Identities = 21/43 (48%), Positives = 29/43 (67%), Gaps = 2/43 (4%)
 Frame = -1

Query: 305 LNRDQWNNVLXFSRSIL--PDLSNYDFDGAWPVLIDDFVEFVK 183
           L +D WN +  FS  +   P+ SNYDF+GAWP LID+FV + +
Sbjct: 200 LPKDTWNELWDFSVFVKSDPNCSNYDFEGAWPTLIDEFVSYYR 242

>DCN1_YARLI (Q6C0B6) Defective in cullin neddylation protein 1|
          Length = 240

 Score = 45.8 bits (107), Expect = 2e-05
 Identities = 21/45 (46%), Positives = 31/45 (68%), Gaps = 2/45 (4%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFS--RSILPDLSNYDFDGAWPVLIDDFVEFVK 183
           R ++RD WN +  F   ++  P L +YD DGAWP +ID++VEF+K
Sbjct: 195 RNISRDAWNMLYEFMLFQAKDPSLESYDEDGAWPSVIDEYVEFLK 239

>DCN1_CAEBR (Q60YT5) Defective in cullin neddylation protein 1|
          Length = 292

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 20/38 (52%), Positives = 24/38 (63%)
 Frame = -1

Query: 305 LNRDQWNNVLXFSRSILPDLSNYDFDGAWPVLIDDFVE 192
           + RD WN    F      DLS+YD +GAWPVLID FV+
Sbjct: 230 ITRDTWNLFWDFIVLGKEDLSDYDEEGAWPVLIDQFVD 267

>DCN1_MAGGR (Q52DM9) Defective in cullin neddylation protein 1|
          Length = 281

 Score = 37.0 bits (84), Expect = 0.011
 Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 2/45 (4%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPD--LSNYDFDGAWPVLIDDFVEFVK 183
           R +++D WN  L F+     D  LS +  +G+WP +ID FVE+++
Sbjct: 223 RTVSKDMWNQTLDFAVKSTADSTLSFWTPEGSWPSVIDGFVEWLR 267

>DCN1_EMENI (Q5AWS1) Defective in cullin neddylation protein 1|
          Length = 308

 Score = 34.3 bits (77), Expect = 0.073
 Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
 Frame = -1

Query: 305 LNRDQWNNVLXFSRSILPD--LSNYDFDGAWPVLIDDFVEFVK 183
           +N+D W  V  F R    D     +  DGAWP  +DDFV +V+
Sbjct: 255 VNKDLWQQVEVFMRKTHEDEAFGWWSEDGAWPGTLDDFVAWVR 297

>DCN1_YEAST (Q12395) Defective in cullin neddylation protein 1|
          Length = 269

 Score = 33.5 bits (75), Expect = 0.12
 Identities = 15/41 (36%), Positives = 25/41 (60%), Gaps = 3/41 (7%)
 Frame = -1

Query: 305 LNRDQWNNVLXFSR---SILPDLSNYDFDGAWPVLIDDFVE 192
           +++D W  +L F +   +I   +S+YD   AWP +ID+F E
Sbjct: 223 ISKDTWRMLLLFFKRYPTIQKIISDYDETAAWPFIIDEFYE 263

>DCN1_ASHGO (Q750Y3) Defective in cullin neddylation protein 1|
          Length = 256

 Score = 33.1 bits (74), Expect = 0.16
 Identities = 15/45 (33%), Positives = 28/45 (62%), Gaps = 3/45 (6%)
 Frame = -1

Query: 305 LNRDQWNNVLXFSRSILPD---LSNYDFDGAWPVLIDDFVEFVKG 180
           ++RD W+    F++    D   L +Y+   +WP++ID++ E+VKG
Sbjct: 208 VSRDTWDMFPRFAQRFPDDTELLEHYNELASWPLVIDEYYEWVKG 252

>DCN1_CANGA (Q6FJR2) Defective in cullin neddylation protein 1|
          Length = 273

 Score = 30.0 bits (66), Expect = 1.4
 Identities = 14/47 (29%), Positives = 27/47 (57%), Gaps = 4/47 (8%)
 Frame = -1

Query: 311 RVLNRDQWNNVLXFSRSILPDL----SNYDFDGAWPVLIDDFVEFVK 183
           +++++D W  +L F +   P L    + Y+   AWP  ID+F E+++
Sbjct: 223 KLIHKDTWQMLLLFFKKF-PSLDAIKTEYNEADAWPYTIDEFYEYLE 268

>CSE1_DROME (Q9XZU1) Importin-alpha re-exporter (Cellular apoptosis|
           susceptibility protein homolog)
          Length = 975

 Score = 29.3 bits (64), Expect = 2.3
 Identities = 13/25 (52%), Positives = 15/25 (60%), Gaps = 1/25 (4%)
 Frame = -1

Query: 248 LSNYDFDGAWPVLIDDFVE-FVKGD 177
           +  YDF   WP LID+ VE F  GD
Sbjct: 121 IGKYDFPKKWPQLIDEMVERFASGD 145

>DCN1_CANAL (Q5ADL9) Defective in cullin neddylation protein 1|
          Length = 304

 Score = 28.9 bits (63), Expect = 3.1
 Identities = 14/44 (31%), Positives = 25/44 (56%), Gaps = 4/44 (9%)
 Frame = -1

Query: 305 LNRDQWNNV-LXFSRSILPD---LSNYDFDGAWPVLIDDFVEFV 186
           ++ D W+   L F   +L D     +YD   AWP ++D+F+E++
Sbjct: 255 ISYDSWSMFYLFFKEIVLIDPIKFKDYDEMAAWPSVVDEFLEYL 298

>KDSB_HELPY (O25016) 3-deoxy-manno-octulosonate cytidylyltransferase (EC|
           2.7.7.38) (CMP-KDO synthetase)
           (CMP-2-keto-3-deoxyoctulosonic acid synthetase) (CKS)
          Length = 243

 Score = 28.9 bits (63), Expect = 3.1
 Identities = 13/29 (44%), Positives = 18/29 (62%)
 Frame = -1

Query: 296 DQWNNVLXFSRSILPDLSNYDFDGAWPVL 210
           D  NN L FSRS++P L ++D     P+L
Sbjct: 140 DSQNNALYFSRSLIPFLRDFDAKRQTPLL 168

>KDSB_HELPJ (Q9ZMK4) 3-deoxy-manno-octulosonate cytidylyltransferase (EC|
           2.7.7.38) (CMP-KDO synthetase)
           (CMP-2-keto-3-deoxyoctulosonic acid synthetase) (CKS)
          Length = 243

 Score = 28.9 bits (63), Expect = 3.1
 Identities = 13/29 (44%), Positives = 18/29 (62%)
 Frame = -1

Query: 296 DQWNNVLXFSRSILPDLSNYDFDGAWPVL 210
           D  NN L FSRS++P L ++D     P+L
Sbjct: 140 DSQNNALYFSRSLIPFLRDFDAKRQTPLL 168

>SYV_METMA (Q8Q024) Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase)|
           (ValRS)
          Length = 869

 Score = 27.7 bits (60), Expect = 6.8
 Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 10/49 (20%)
 Frame = -1

Query: 296 DQW--NNVLXFSRSILPDLSNYDFDG--------AWPVLIDDFVEFVKG 180
           D+W  + +     S   +L  Y FD         AW VL D+++E VKG
Sbjct: 606 DRWLLSKLNRLVESTTKELDGYQFDSTFKAIRGFAWEVLADNYLELVKG 654

>SYV_METBF (Q46B32) Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase)|
           (ValRS)
          Length = 869

 Score = 27.3 bits (59), Expect = 8.9
 Identities = 13/32 (40%), Positives = 18/32 (56%), Gaps = 8/32 (25%)
 Frame = -1

Query: 251 DLSNYDFDG--------AWPVLIDDFVEFVKG 180
           +L +Y FD         AW VL D+++E VKG
Sbjct: 623 ELDDYQFDSTFKAIRGFAWEVLADNYLELVKG 654


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,675,591
Number of Sequences: 219361
Number of extensions: 616399
Number of successful extensions: 1183
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 1175
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1182
length of database: 80,573,946
effective HSP length: 109
effective length of database: 56,663,597
effective search space used: 1359926328
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)