ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags8g23 |
|---|---|
| Clone Library Name | barley_pub |
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 171 bits (432), Expect(2) = 2e-44 Identities = 85/147 (57%), Positives = 105/147 (71%), Gaps = 1/147 (0%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 LDW R+KIA AAKG+E+LH+K P +I+RD +SSN+LL E F K++DF L P Sbjct: 182 LDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTG 241 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 STRV+GT+GY APEYAMTGQLT KSDVYSFGVV LEL+TGRK +D MP G+Q+L Sbjct: 242 DKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQNL 301 Query: 463 VTWATPRLSE-DKVKQCVDPRLKGEYP 540 V WA P ++ K + DPRLKG +P Sbjct: 302 VAWARPLFNDRRKFIKLADPRLKGRFP 328 Score = 27.7 bits (60), Expect(2) = 2e-44 Identities = 12/29 (41%), Positives = 14/29 (48%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAW 95 R+L YEF +GSL D LH W Sbjct: 156 RLLVYEFMPLGSLEDHLHDLPPDKEALDW 184
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 164 bits (416), Expect(2) = 7e-42 Identities = 80/147 (54%), Positives = 108/147 (73%), Gaps = 1/147 (0%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 LDW R+KIA AA+G+EYLH+++ P +I+RD++ SN+LL ED++ K++DF L P Sbjct: 199 LDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSG 258 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 STRV+GT+GY AP+YAMTGQLT KSD+YSFGVVLLEL+TGRK +D+T R Q+L Sbjct: 259 DKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKDQNL 318 Query: 463 VTWATPRLSEDK-VKQCVDPRLKGEYP 540 V WA P + + + VDP L+G+YP Sbjct: 319 VGWARPLFKDRRNFPKMVDPLLQGQYP 345 Score = 25.4 bits (54), Expect(2) = 7e-42 Identities = 13/25 (52%), Positives = 15/25 (60%), Gaps = 4/25 (16%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLH----GKK 71 R+L YE+ GSL D LH GKK Sbjct: 173 RLLVYEYMPQGSLEDHLHVLPSGKK 197
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 141 bits (356), Expect(2) = 1e-35 Identities = 72/146 (49%), Positives = 96/146 (65%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +LDW R+ IA+ AA+G+ YLH S+IHRD++SSN+LL + AK+ADF AP Sbjct: 690 ILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQ 749 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQS 459 S V GT GY PEY T QL++KSDV+SFGVVLLE+++GR+P++ PR + S Sbjct: 750 EGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRIEWS 809 Query: 460 LVTWATPRLSEDKVKQCVDPRLKGEY 537 LV WA P + KV + VDP +KG Y Sbjct: 810 LVEWAKPYIRASKVDEIVDPGIKGGY 835 Score = 27.3 bits (59), Expect(2) = 1e-35 Identities = 12/30 (40%), Positives = 17/30 (56%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAWP 98 +IL Y F + GSL D L+G+ + WP Sbjct: 665 QILVYPFMSNGSLLDRLYGEASKRKILDWP 694
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 141 bits (355), Expect(2) = 2e-35 Identities = 72/146 (49%), Positives = 95/146 (65%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +LDW R+ IA+ AA+G+ YLH S+IHRD++SSN+LL AK+ADF AP Sbjct: 689 ILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQ 748 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQS 459 S V GT GY PEY T QL++KSDV+SFGVVLLE+++GR+P++ PR + S Sbjct: 749 EGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRVEWS 808 Query: 460 LVTWATPRLSEDKVKQCVDPRLKGEY 537 LV WA P + KV + VDP +KG Y Sbjct: 809 LVEWAKPYIRASKVDEIVDPGIKGGY 834 Score = 27.3 bits (59), Expect(2) = 2e-35 Identities = 12/30 (40%), Positives = 17/30 (56%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAWP 98 +IL Y F + GSL D L+G+ + WP Sbjct: 664 QILVYPFMSNGSLLDRLYGEPAKRKILDWP 693
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 143 bits (361), Expect(2) = 3e-35 Identities = 74/147 (50%), Positives = 104/147 (70%), Gaps = 2/147 (1%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L W RV++A+ AA+G+ +LH QP +I+RD ++SN+LL ++ AK++DF L P M Sbjct: 173 LSWNTRVRMALGAARGLAFLHN-AQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGP-M 230 Query: 283 AARLH-STRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQS 459 H STRV+GT GY APEY TG L+ KSDVYSFGVVLLELL+GR+ +D P G+ + Sbjct: 231 GDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKNQPVGEHN 290 Query: 460 LVTWATPRL-SEDKVKQCVDPRLKGEY 537 LV WA P L ++ ++ + +DPRL+G+Y Sbjct: 291 LVDWARPYLTNKRRLLRVMDPRLQGQY 317 Score = 24.3 bits (51), Expect(2) = 3e-35 Identities = 11/30 (36%), Positives = 17/30 (56%) Frame = +3 Query: 6 YRILAYEFATMGSLHDVLHGKKRSSRCAAW 95 +R+L YEF T GSL + L + + +W Sbjct: 146 HRLLVYEFMTRGSLENHLFRRGTFYQPLSW 175
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 142 bits (358), Expect(2) = 4e-34 Identities = 71/146 (48%), Positives = 101/146 (69%), Gaps = 1/146 (0%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L W R+K+A+ AAKG+ +LH + S+I+RD ++SN+LL ++ AK++DF L P Sbjct: 174 LSWTLRLKVALGAAKGLAFLHN-AETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTG 232 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 STR++GT+GY APEY TG LT KSDVYS+GVVLLE+L+GR+ VD P G+Q L Sbjct: 233 DKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRRAVDKNRPPGEQKL 292 Query: 463 VTWATPRL-SEDKVKQCVDPRLKGEY 537 V WA P L ++ K+ + +D RL+ +Y Sbjct: 293 VEWARPLLANKRKLFRVIDNRLQDQY 318 Score = 21.9 bits (45), Expect(2) = 4e-34 Identities = 10/30 (33%), Positives = 16/30 (53%) Frame = +3 Query: 6 YRILAYEFATMGSLHDVLHGKKRSSRCAAW 95 +R+L YEF GSL + L + + +W Sbjct: 147 HRLLVYEFMPRGSLENHLFRRGSYFQPLSW 176
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 140 bits (354), Expect(2) = 1e-33 Identities = 72/146 (49%), Positives = 100/146 (68%), Gaps = 1/146 (0%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L W R+K+A+ AAKG+ +LH + +I+RD ++SN+LL ++ AK++DF L P Sbjct: 173 LSWKLRLKVALGAAKGLAFLHSS-ETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIG 231 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 STRV+GT GY APEY TG LT KSDVYSFGVVLLELL+GR+ VD P G+++L Sbjct: 232 DKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRRAVDKNRPSGERNL 291 Query: 463 VTWATPRL-SEDKVKQCVDPRLKGEY 537 V WA P L ++ K+ + +D RL+ +Y Sbjct: 292 VEWAKPYLVNKRKIFRVIDNRLQDQY 317 Score = 21.6 bits (44), Expect(2) = 1e-33 Identities = 9/18 (50%), Positives = 12/18 (66%) Frame = +3 Query: 6 YRILAYEFATMGSLHDVL 59 +R+L YEF GSL + L Sbjct: 146 HRLLVYEFMPRGSLENHL 163
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 137 bits (345), Expect = 2e-32 Identities = 66/131 (50%), Positives = 93/131 (70%) Frame = +1 Query: 79 QGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN 258 +G +P L W QR+ +A++ A+G+EYLH S IHRD++ SN+LL +D +AK+ADF Sbjct: 681 EGLKP---LLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFG 737 Query: 259 LLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHT 438 L+ AP+ + TR+ GTFGY APEYA+TG++T K DVYSFGV+L+EL+TGRK +D + Sbjct: 738 LVRLAPEGKGSIE-TRIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRKSLDES 796 Query: 439 MPRGQQSLVTW 471 P LV+W Sbjct: 797 QPEESIHLVSW 807
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 124 bits (312), Expect(2) = 2e-32 Identities = 61/146 (41%), Positives = 94/146 (64%), Gaps = 2/146 (1%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNL--LN 267 G VL W +R++IA++AA+G+ YLH P I+HRD++SSN+LL D+ AK+ADF + + Sbjct: 785 GVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVG 844 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPR 447 Q + + G+ GY APEY T ++ +KSD+YSFGVVLLEL+TG++P D + Sbjct: 845 QMSGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQPTDSEL-- 902 Query: 448 GQQSLVTWATPRLSEDKVKQCVDPRL 525 G + + W L + ++ +DP+L Sbjct: 903 GDKDMAKWVCTALDKCGLEPVIDPKL 928 Score = 33.5 bits (75), Expect(2) = 2e-32 Identities = 13/30 (43%), Positives = 18/30 (60%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAWP 98 ++L YE+ GSL DVLHG ++ WP Sbjct: 762 KLLVYEYMPNGSLADVLHGDRKGGVVLGWP 791
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 127 bits (318), Expect(2) = 2e-31 Identities = 68/141 (48%), Positives = 88/141 (62%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L+W +RV IA++AA+GIEYLH P +IHRDI+SSN+L+ ED A++ADF L P Sbjct: 603 LNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPAD 662 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 + S GT GY PEY LT KSDVYSFGVVLLE+L+GRK +D G ++ Sbjct: 663 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQFEEG--NI 720 Query: 463 VTWATPRLSEDKVKQCVDPRL 525 V WA P + + +DP L Sbjct: 721 VEWAVPLIKAGDIFAILDPVL 741 Score = 28.5 bits (62), Expect(2) = 2e-31 Identities = 12/20 (60%), Positives = 14/20 (70%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGK 68 R+L YEF GSL+ LHGK Sbjct: 576 RLLVYEFMAHGSLYQHLHGK 595
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 133 bits (334), Expect = 4e-31 Identities = 68/144 (47%), Positives = 97/144 (67%), Gaps = 1/144 (0%) Frame = +1 Query: 109 WMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAA 288 W R+KI I AA+G+ +LH +Q +I+RD ++SN+LL ++ AK++DF L P Sbjct: 190 WDLRIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEK 248 Query: 289 RLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVT 468 +TR++GT+GY APEY TG L KSDV++FGVVLLE++TG + PRGQ+SLV Sbjct: 249 SHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTKRPRGQESLVD 308 Query: 469 WATPRLS-EDKVKQCVDPRLKGEY 537 W P LS + +VKQ +D +KG+Y Sbjct: 309 WLRPELSNKHRVKQIMDKGIKGQY 332
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 132 bits (332), Expect = 6e-31 Identities = 66/141 (46%), Positives = 89/141 (63%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P LDW R++IA AA+G+ YLH+ +P I+HRDI+SSN+LL + F A +ADF L Sbjct: 836 PSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLIL 895 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQ 456 + +T ++GT GY PEY T K DVYSFGVVLLELLTGR+P+D PRG + Sbjct: 896 PYDTHV-TTDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTGRRPMDVCKPRGSR 954 Query: 457 SLVTWATPRLSEDKVKQCVDP 519 L++W +E + + DP Sbjct: 955 DLISWVLQMKTEKRESEIFDP 975
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 123 bits (309), Expect(2) = 8e-30 Identities = 64/144 (44%), Positives = 88/144 (61%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G LDW R KIAI AA+G+ +LH P IIHRD++SSNVLL +DF A+++DF + Sbjct: 951 GIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLV 1010 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + L + + GT GY PEY + + T K DVYS+GV+LLELL+G+KP+D Sbjct: 1011 SALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPEEFGED 1070 Query: 454 QSLVTWATPRLSEDKVKQCVDPRL 525 +LV WA E + + +DP L Sbjct: 1071 NNLVGWAKQLYREKRGAEILDPEL 1094 Score = 26.2 bits (56), Expect(2) = 8e-30 Identities = 11/22 (50%), Positives = 14/22 (63%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKR 74 R+L YE+ GSL VLH K + Sbjct: 927 RLLVYEYMKYGSLETVLHEKTK 948
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 128 bits (322), Expect = 9e-30 Identities = 67/143 (46%), Positives = 88/143 (61%), Gaps = 1/143 (0%) Frame = +1 Query: 94 GP-VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 GP +L W R++IA AAKG+ YLHE P I+HRDI+SSN+LL E+F + +ADF L Sbjct: 825 GPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARL 884 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRG 450 + ST ++GT GY PEY T K DVYSFGVVLLELLT ++PVD P+G Sbjct: 885 MSPYETHV-STDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKRPVDMCKPKG 943 Query: 451 QQSLVTWATPRLSEDKVKQCVDP 519 + L++W E + + DP Sbjct: 944 CRDLISWVVKMKHESRASEVFDP 966
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 123 bits (309), Expect(2) = 1e-29 Identities = 64/144 (44%), Positives = 89/144 (61%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L+W R KIAI AA+G+ +LH P IIHRD++SSNVLL EDF+A+++DF + Sbjct: 953 GIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLV 1012 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + L + + GT GY PEY + + T K DVYS+GV+LLELL+G+KP+D Sbjct: 1013 SALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGED 1072 Query: 454 QSLVTWATPRLSEDKVKQCVDPRL 525 +LV WA E + + +DP L Sbjct: 1073 NNLVGWAKQLYREKRGAEILDPEL 1096 Score = 25.8 bits (55), Expect(2) = 1e-29 Identities = 11/20 (55%), Positives = 13/20 (65%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGK 68 R+L YE+ GSL VLH K Sbjct: 928 RLLVYEYMKWGSLETVLHEK 947
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 124 bits (310), Expect(2) = 1e-29 Identities = 73/158 (46%), Positives = 98/158 (62%), Gaps = 9/158 (5%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L W R ++A+EAAKG+ YLH P I+HRD++S+N+LL DF+A +ADF L Sbjct: 783 GGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFL 842 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 D AA + + G++GY APEYA T ++ +KSDVYSFGVVLLEL+ G+KPV G Sbjct: 843 VDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGKKPVGE-FGEG- 900 Query: 454 QSLVTWATPRLSEDKVKQ---------CVDPRLKGEYP 540 +V W R +E+++ Q VDPRL G YP Sbjct: 901 VDIVRWV--RNTEEEITQPSDAAIVVAIVDPRLTG-YP 935 Score = 25.4 bits (54), Expect(2) = 1e-29 Identities = 10/20 (50%), Positives = 14/20 (70%) Frame = +3 Query: 12 ILAYEFATMGSLHDVLHGKK 71 +L YE+ GSL ++LHG K Sbjct: 763 LLLYEYMPNGSLGELLHGSK 782
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 127 bits (319), Expect = 2e-29 Identities = 65/143 (45%), Positives = 92/143 (64%), Gaps = 1/143 (0%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 VLDW +R+KIA+ AA+G+ +LH P IIHRDI++SN+LL DF+ K+ADF L Sbjct: 1011 VLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISA 1070 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ-Q 456 + + ST + GTFGY PEY + + T K DVYSFGV+LLEL+TG++P + Sbjct: 1071 CESHV-STVIAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEPTGPDFKESEGG 1129 Query: 457 SLVTWATPRLSEDKVKQCVDPRL 525 +LV WA ++++ K +DP L Sbjct: 1130 NLVGWAIQKINQGKAVDVIDPLL 1152
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 115 bits (288), Expect(2) = 5e-29 Identities = 63/149 (42%), Positives = 90/149 (60%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L+W R KIAI +A+G+ +LH P IIHRD++SSNVLL E+ +A+++DF + Sbjct: 975 GVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM 1034 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 M L + + GT GY PEY + + + K DVYS+GVVLLELLTG++P D + G Sbjct: 1035 SAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTD-SPDFGD 1093 Query: 454 QSLVTWATPRLSEDKVKQCVDPRLKGEYP 540 +LV W ++ ++ DP L E P Sbjct: 1094 NNLVGWVKQH-AKLRISDVFDPELMKEDP 1121 Score = 31.6 bits (70), Expect(2) = 5e-29 Identities = 14/29 (48%), Positives = 17/29 (58%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAW 95 R+L YEF GSL DVLH K++ W Sbjct: 952 RLLVYEFMKYGSLEDVLHDPKKAGVKLNW 980
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 110 bits (276), Expect(2) = 2e-28 Identities = 59/126 (46%), Positives = 81/126 (64%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L+W R KIAI AA+G+ +LH P IIHRD++SSNVLL E+ +A+++DF + Sbjct: 980 GIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLM 1039 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 M L + + GT GY PEY + + + K DVYS+GVVLLELLTG++P D + G Sbjct: 1040 SAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTD-SADFGD 1098 Query: 454 QSLVTW 471 +LV W Sbjct: 1099 NNLVGW 1104 Score = 34.3 bits (77), Expect(2) = 2e-28 Identities = 14/30 (46%), Positives = 19/30 (63%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAWP 98 R+L YE+ GSL DVLH +K++ WP Sbjct: 957 RLLVYEYMKYGSLEDVLHDRKKTGIKLNWP 986
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 110 bits (276), Expect(2) = 4e-28 Identities = 59/126 (46%), Positives = 81/126 (64%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L+W R KIAI AA+G+ +LH P IIHRD++SSNVLL E+ +A+++DF + Sbjct: 980 GIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLM 1039 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 M L + + GT GY PEY + + + K DVYS+GVVLLELLTG++P D + G Sbjct: 1040 SAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTD-SADFGD 1098 Query: 454 QSLVTW 471 +LV W Sbjct: 1099 NNLVGW 1104 Score = 33.1 bits (74), Expect(2) = 4e-28 Identities = 14/30 (46%), Positives = 18/30 (60%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAWP 98 R+L YE+ GSL DVLH +K+ WP Sbjct: 957 RLLVYEYMKYGSLEDVLHDRKKIGIKLNWP 986
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 111 bits (278), Expect(2) = 2e-27 Identities = 60/145 (41%), Positives = 87/145 (60%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +L W +R KIA AAKG+ +LH P IIHRD++SSNVLL +D +A+++DF + Sbjct: 934 ILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISA 993 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQS 459 + L + + GT GY PEY + + T K DVYS GVV+LE+L+G++P D G + Sbjct: 994 LDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDKE-EFGDTN 1052 Query: 460 LVTWATPRLSEDKVKQCVDPRLKGE 534 LV W+ + E K + +D L E Sbjct: 1053 LVGWSKMKAREGKHMEVIDEDLLKE 1077 Score = 30.0 bits (66), Expect(2) = 2e-27 Identities = 12/25 (48%), Positives = 16/25 (64%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSR 83 R+L YEF GSL +VLHG + + Sbjct: 907 RLLVYEFMQYGSLEEVLHGPRTGEK 931
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 117 bits (294), Expect = 2e-26 Identities = 61/149 (40%), Positives = 93/149 (62%), Gaps = 2/149 (1%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P LDW +R +IA+ +A+G+ YLH+ P IIHRD++++N+LL E+F+A + DF L + Sbjct: 383 PPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLA-KLM 441 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQ 456 D +T V GT G+ APEY TG+ ++K+DV+ +GV+LLEL+TG++ D Sbjct: 442 DYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDD 501 Query: 457 S--LVTWATPRLSEDKVKQCVDPRLKGEY 537 L+ W L E K++ VD L+G Y Sbjct: 502 DVMLLDWVKGLLKEKKLEALVDVDLQGNY 530
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 109 bits (272), Expect(2) = 1e-25 Identities = 60/149 (40%), Positives = 86/149 (57%), Gaps = 1/149 (0%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P LDW R IA+ A G+ YLH P+I+HRDI+ N+LL D + I+DF + Sbjct: 907 PPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKL 966 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRG 450 A + S V GT GY APE A T +++SDVYS+GVVLLEL+T +K +D + G Sbjct: 967 LDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKKALDPSF-NG 1025 Query: 451 QQSLVTWATPRLSE-DKVKQCVDPRLKGE 534 + +V W ++ ++++ VDP L E Sbjct: 1026 ETDIVGWVRSVWTQTGEIQKIVDPSLLDE 1054 Score = 26.2 bits (56), Expect(2) = 1e-25 Identities = 9/19 (47%), Positives = 13/19 (68%) Frame = +3 Query: 6 YRILAYEFATMGSLHDVLH 62 Y ++ Y + GSLHD+LH Sbjct: 885 YGLILYTYMENGSLHDILH 903
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 111 bits (277), Expect(2) = 5e-25 Identities = 59/146 (40%), Positives = 89/146 (60%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +L W +R+KI+++AA+G+EYLH +P I+HRD++ +N+LL E +AK+ADF L Sbjct: 665 ILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSV 724 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQS 459 + ST V G+ GY PEY T Q+ +KSDVYS GVVLLE++TG +P + + Sbjct: 725 EGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITG-QPAIASSKTEKVH 783 Query: 460 LVTWATPRLSEDKVKQCVDPRLKGEY 537 + L+ ++ VD RL+ Y Sbjct: 784 ISDHVRSILANGDIRGIVDQRLRERY 809 Score = 22.3 bits (46), Expect(2) = 5e-25 Identities = 9/23 (39%), Positives = 14/23 (60%) Frame = +3 Query: 3 NYRILAYEFATMGSLHDVLHGKK 71 N+ +L YE+ +L D L GK+ Sbjct: 640 NHMVLIYEYMANENLGDYLAGKR 662
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 107 bits (267), Expect = 2e-23 Identities = 60/118 (50%), Positives = 78/118 (66%), Gaps = 1/118 (0%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P L W R KIA AA GI +LHE IHRDI+S+N+LL E F AKI+DF L + Sbjct: 281 PPLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASE 337 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD-HTMPR 447 A + ++R++GT Y APE A+ G++T KSD+YSFGVVLLE++TG VD H P+ Sbjct: 338 KFAQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQ 394
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 107 bits (267), Expect = 2e-23 Identities = 57/112 (50%), Positives = 76/112 (67%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P L W R K+A A GI +LHE IHRDI+S+N+LL +DF AKI+DF L + Sbjct: 281 PPLSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASA 337 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 +A + ++R++GT Y APE A+ G++T KSD+YSFGVVLLEL+TG VD Sbjct: 338 RLAQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSFGVVLLELITGLAAVD 388
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 100 bits (249), Expect = 3e-21 Identities = 51/139 (36%), Positives = 85/139 (61%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L+W +R I A+G+ YLH+ + IIHRD++ SN+LL ++ KI+DF + Sbjct: 622 LNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERD 681 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 ++ +V+GT+GY +PEYAM G ++KSDV+SFGV++LE+++G+K + L Sbjct: 682 ETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKKNRGFYNLDYENDL 741 Query: 463 VTWATPRLSEDKVKQCVDP 519 +++ R E + + VDP Sbjct: 742 LSYVWSRWKEGRALEIVDP 760
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 93.6 bits (231), Expect = 3e-19 Identities = 48/108 (44%), Positives = 67/108 (62%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +LDW R IA+ AKG+ YLH + +IH D++ N+LL + F+ KI DF L+ Sbjct: 626 LLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNR 685 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRK 423 + + + V GT GY APE+ + +T K DVYS+GVVLLELLTG + Sbjct: 686 GGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTR 733
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 85.5 bits (210), Expect(2) = 6e-18 Identities = 50/121 (41%), Positives = 70/121 (57%), Gaps = 7/121 (5%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 Q P L W QR+ I + A+ I++LH+ PS+IH DI+SSNVLL E K+ DF L Sbjct: 305 QACPPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLTPKLGDFGLAR 363 Query: 268 ------QAPDMAARLHSTR-VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 +P ++ + T+ V GT Y EY TG+L +D +SFGVV+LE L G++ Sbjct: 364 FSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRA 423 Query: 427 V 429 V Sbjct: 424 V 424 Score = 24.3 bits (51), Expect(2) = 6e-18 Identities = 11/28 (39%), Positives = 15/28 (53%) Frame = +3 Query: 15 LAYEFATMGSLHDVLHGKKRSSRCAAWP 98 L Y F GSL D LH + ++ +WP Sbjct: 286 LVYGFLPNGSLEDRLHCQTQACPPLSWP 313
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 89.0 bits (219), Expect = 8e-18 Identities = 48/115 (41%), Positives = 68/115 (59%), Gaps = 1/115 (0%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P P L W QR I++ A+GI +LH +IH DI+ +N+LL + + KI DF L+ + Sbjct: 311 PLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVRE 370 Query: 271 AP-DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 P + A + +V GT Y PE+ QL+ DVYSFG+VLLE+ TGR+ D Sbjct: 371 GPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTD 425
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 83.2 bits (204), Expect(2) = 2e-17 Identities = 47/116 (40%), Positives = 66/116 (56%), Gaps = 7/116 (6%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN----- 267 L W QR+ I + A+ I++LH+ PS+IH DI+SSNVLL E K+ DF L Sbjct: 310 LSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFA 368 Query: 268 --QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +A + ++ V GT Y EY TG+L +D +SFGVV+LE L G++ V Sbjct: 369 GAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAV 424 Score = 24.6 bits (52), Expect(2) = 2e-17 Identities = 11/28 (39%), Positives = 15/28 (53%) Frame = +3 Query: 15 LAYEFATMGSLHDVLHGKKRSSRCAAWP 98 L Y F GSL D LH + ++ +WP Sbjct: 286 LVYGFLPNGSLEDQLHLQTQACSPLSWP 313
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 80.1 bits (196), Expect(2) = 2e-16 Identities = 44/110 (40%), Positives = 66/110 (60%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P L+W +R KIA+ A+G+ YLH + IIH +IRS NVL+ + F A++ +F L++ Sbjct: 467 PALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFG-LDKIM 525 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 A + GY APE + +SDVY+FG++LLE+L G+KP Sbjct: 526 VQAVADEIVSQAKSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKP 575 Score = 24.6 bits (52), Expect(2) = 2e-16 Identities = 10/29 (34%), Positives = 15/29 (51%) Frame = +3 Query: 9 RILAYEFATMGSLHDVLHGKKRSSRCAAW 95 ++L Y++ SLHD+LH K W Sbjct: 443 KLLIYDYLPNISLHDLLHESKPRKPALNW 471
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 79.7 bits (195), Expect = 5e-15 Identities = 47/116 (40%), Positives = 67/116 (57%), Gaps = 1/116 (0%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +LD ++ IA++ AKG+EYLH QP IIHRD+ S N+LL+ED A +ADF Sbjct: 556 ILDLQSKLIIAVDVAKGMEYLHSLTQP-IIHRDLNSHNILLYEDGHAVVADFGESRFLQS 614 Query: 280 MAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + + T+ G + APE + + T K+DV+S+ + L ELLTG P H P Sbjct: 615 LDED-NMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLTGEIPFAHLKP 669
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 79.0 bits (193), Expect = 8e-15 Identities = 46/116 (39%), Positives = 67/116 (57%), Gaps = 1/116 (0%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +LD ++ IA++ AKG+EYLH QP IIHRD+ S N+LL+ED A +ADF Sbjct: 658 ILDLQSKLIIAVDVAKGMEYLHNLTQP-IIHRDLNSHNILLYEDGHAVVADFGESRFLQS 716 Query: 280 MAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + + T+ G + APE + + T K+DV+S+ + L E+LTG P H P Sbjct: 717 LDED-NMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 771
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 78.6 bits (192), Expect = 1e-14 Identities = 49/135 (36%), Positives = 72/135 (53%), Gaps = 13/135 (9%) Frame = +1 Query: 118 RVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLF-------------EDFKAKIADFN 258 R+K+A++ AKG+ YLH P I+HRD+ S N+LL +D K KI+DF Sbjct: 1392 RLKLALDIAKGMNYLHGWTPP-ILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFG 1450 Query: 259 LLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHT 438 L + A+++ T+ +G Y APE ++KSDVYS+G+VL ELLT +P Sbjct: 1451 LSRLKKEQASQM--TQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDM 1508 Query: 439 MPRGQQSLVTWATPR 483 P L + + R Sbjct: 1509 KPMKMAHLAAYESYR 1523
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 77.4 bits (189), Expect = 2e-14 Identities = 46/116 (39%), Positives = 66/116 (56%), Gaps = 1/116 (0%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 +LD ++ IA++ AKG+EYLH QP IIHRD+ S N+LL+ED A +ADF Sbjct: 555 ILDLQSKLIIAVDVAKGMEYLHSLTQP-IIHRDLNSHNILLYEDGHAVVADFGESRFLQS 613 Query: 280 MAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + + T+ G + APE + + T K+DV+S+ + L ELL G P H P Sbjct: 614 LDED-NMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLIGEIPFAHLKP 668
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 76.6 bits (187), Expect = 4e-14 Identities = 47/128 (36%), Positives = 70/128 (54%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 LD +R+ +A + AKG+ YLH + P I+HRD++S N+L+ + + K+ DF L Sbjct: 646 LDERRRLSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKA-- 702 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSL 462 + L S GT + APE +KSDVYSFGV+L EL T ++P + P + Sbjct: 703 STFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAA 762 Query: 463 VTWATPRL 486 V + RL Sbjct: 763 VGFKCKRL 770
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 76.3 bits (186), Expect = 5e-14 Identities = 43/112 (38%), Positives = 63/112 (56%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P + + ++K+ AA GI+YLH P I+HRDI+ +N+L+ E F KIADF Sbjct: 1453 PDIKITFANKLKLLYGAAMGIDYLHSS-NPMIVHRDIKPANILVDEHFNVKIADFGFARI 1511 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D GT + APE + +K+DV+SFGVV+ E+LTG++P Sbjct: 1512 KEDNTTMTRC----GTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKEP 1559 Score = 71.6 bits (174), Expect = 1e-12 Identities = 38/118 (32%), Positives = 65/118 (55%), Gaps = 2/118 (1%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P + + ++K+A +A+KG+ +LH I+HRD++S N+LL + K++DF L Sbjct: 878 PEIPYALKIKMAYQASKGMHFLHSS---GIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKS 934 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQ--KSDVYSFGVVLLELLTGRKPVDHTMP 444 ++ + + ++GT + APE +DVYSFG++L ELLT +P P Sbjct: 935 ELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTP 992
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 75.1 bits (183), Expect = 1e-13 Identities = 43/116 (37%), Positives = 63/116 (54%), Gaps = 3/116 (2%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 435 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQ 491 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVYS+G+VL EL+TG P H R Q Sbjct: 492 QVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIRDRDQ 547
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 74.7 bits (182), Expect = 2e-13 Identities = 39/112 (34%), Positives = 67/112 (59%), Gaps = 1/112 (0%) Frame = +1 Query: 112 MQRVKIA-IEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAA 288 M R+K A ++ + + Y+H ++HRD++ SN+++ +D + ++ DF L D AA Sbjct: 218 MGRLKDAMLQICEALAYIHGH---GLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAA 274 Query: 289 RLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + +++GT+ Y APE + L ++D+YS GV+L ELL+GR P D P Sbjct: 275 ITEAGKLVGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFDAKTP 326
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/132 (35%), Positives = 71/132 (53%), Gaps = 6/132 (4%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 444 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV 465 + G+ + APE + + +SDVYS+G+VL EL+TG P H R Q + Sbjct: 501 QVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM 560 Query: 466 T---WATPRLSE 492 +A+P LS+ Sbjct: 561 VGRGYASPDLSK 572
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/119 (36%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 + ++ + IA + A+G++YLH K SIIHRD++S+N+ L ED KI DF L + Sbjct: 549 EMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 605 Query: 286 ARLHSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVY+FG+VL EL+TG+ P + R Q Sbjct: 606 GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 664
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/119 (36%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 + ++ + IA + A+G++YLH K SIIHRD++S+N+ L ED KI DF L + Sbjct: 159 EMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 215 Query: 286 ARLHSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVY+FG+VL EL+TG+ P + R Q Sbjct: 216 GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 274
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/119 (36%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 + ++ + IA + A+G++YLH K SIIHRD++S+N+ L ED KI DF L + Sbjct: 175 EMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 231 Query: 286 ARLHSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVY+FG+VL EL+TG+ P + R Q Sbjct: 232 GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 290
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/119 (36%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 + ++ + IA + A+G++YLH K SIIHRD++S+N+ L ED KI DF L + Sbjct: 589 EMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 645 Query: 286 ARLHSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVY+FG+VL EL+TG+ P + R Q Sbjct: 646 GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 704
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/119 (36%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 + ++ + IA + A+G++YLH K SIIHRD++S+N+ L ED KI DF L + Sbjct: 111 EMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 167 Query: 286 ARLHSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVY+FG+VL EL+TG+ P + R Q Sbjct: 168 GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 226
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 73.9 bits (180), Expect = 3e-13 Identities = 47/132 (35%), Positives = 70/132 (53%), Gaps = 6/132 (4%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 444 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV 465 + G+ + APE + +SDVYS+G+VL EL+TG P H R Q + Sbjct: 501 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM 560 Query: 466 T---WATPRLSE 492 +A+P LS+ Sbjct: 561 VGRGYASPDLSK 572
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/119 (36%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 + ++ + IA + A+G++YLH K SIIHRD++S+N+ L ED KI DF L + Sbjct: 589 EMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 645 Query: 286 ARLHSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 ++ G+ + APE + +SDVY+FG+VL EL+TG+ P + R Q Sbjct: 646 GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 704
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 73.6 bits (179), Expect = 3e-13 Identities = 46/108 (42%), Positives = 64/108 (59%), Gaps = 1/108 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK-AKIADFNLLNQAPDMAAR 291 Q V+ A++ AK + YLH +P I+HRDI+ N+LL+ + KI DF L A DM+ Sbjct: 107 QAVRWALQCAKALAYLHSLDRP-IVHRDIKPQNMLLYNQHEDLKICDFGL---ATDMSN- 161 Query: 292 LHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDH 435 + T + GT Y APE + T K DVYSFG++L EL+T + P H Sbjct: 162 -NKTDMQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMTRQLPYSH 208
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 73.6 bits (179), Expect = 3e-13 Identities = 47/131 (35%), Positives = 69/131 (52%), Gaps = 6/131 (4%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 444 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV 465 + G+ + APE + +SDVYS+G+VL EL+TG P H R Q + Sbjct: 501 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM 560 Query: 466 T---WATPRLS 489 +A+P LS Sbjct: 561 VGRGYASPDLS 571
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 73.2 bits (178), Expect = 4e-13 Identities = 41/118 (34%), Positives = 64/118 (54%), Gaps = 3/118 (2%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED---FKAKIADFNLLNQA 273 L W RVK+A + A G+ YLH K I HRD+ S N L+ D + A +ADF L + Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFK---GIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPR 447 PD++ V+G+ + APE +K+DV+S+G++L E++ + +PR Sbjct: 205 PDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPR 262
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 73.2 bits (178), Expect = 4e-13 Identities = 39/113 (34%), Positives = 64/113 (56%), Gaps = 4/113 (3%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L W R+ + I AK I+YLH ++I ++ S+N+LL + + K+ DF + P++ Sbjct: 275 LSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNL 334 Query: 283 AARLHSTRVLG----TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 + + + G Y EY G+L+ K+DVYSFG+V++E+LTG K V Sbjct: 335 EQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVV 387
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 72.4 bits (176), Expect = 8e-13 Identities = 43/113 (38%), Positives = 64/113 (56%), Gaps = 11/113 (9%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKA--------KIADFNLLNQAP 276 V AI+ A+G+ YLH + SIIHRD++SSNVL++E + KI DF L Sbjct: 239 VNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGL----- 293 Query: 277 DMAARLHSTR---VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 A +++T+ GT+ + PE ++ SDV+S+GV+L EL+TG P Sbjct: 294 --AREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETP 344
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 72.4 bits (176), Expect = 8e-13 Identities = 41/118 (34%), Positives = 63/118 (53%), Gaps = 3/118 (2%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED---FKAKIADFNLLNQA 273 L W RVK+A + A G+ YLH K I HRD+ S N L+ D + A +ADF L + Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFK---GIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPR 447 PD + V+G+ + APE +K+DV+S+G++L E++ + +PR Sbjct: 205 PDASIGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPR 262
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 72.4 bits (176), Expect = 8e-13 Identities = 41/118 (34%), Positives = 63/118 (53%), Gaps = 3/118 (2%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED---FKAKIADFNLLNQA 273 L W RVK+A + A G+ YLH K I HRD+ S N L+ D + A +ADF L + Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFK---GIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPR 447 PD + V+G+ + APE +K+DV+S+G++L E++ + +PR Sbjct: 205 PDASIGREKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPR 262
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 72.0 bits (175), Expect = 1e-12 Identities = 46/132 (34%), Positives = 70/132 (53%), Gaps = 6/132 (4%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L KI DF L + Sbjct: 177 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQ 233 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV 465 + G+ + APE + + +SDVYS+G+VL EL+TG P H R Q + Sbjct: 234 QVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM 293 Query: 466 T---WATPRLSE 492 +A+P LS+ Sbjct: 294 VGRGYASPDLSK 305
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 72.0 bits (175), Expect = 1e-12 Identities = 38/117 (32%), Positives = 69/117 (58%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L+ + V+IA + + +++ H+ IIHRDI+ N+L+ ++ K+ DF + +A Sbjct: 103 GGPLEVKRAVEIASQVCRALDHAHKN---KIIHRDIKPQNILVTDEDVVKVTDFGIA-RA 158 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + A ++ V+GT Y +PE A + +++D+YS G+VL E+LTG+ P + P Sbjct: 159 ANGATITYTGDVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGKVPFEGDSP 215
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 71.6 bits (174), Expect = 1e-12 Identities = 43/119 (36%), Positives = 64/119 (53%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 +PGP LD +Q I E KG++YLH + + IHRDI+++NVLL E + K+ADF + Sbjct: 112 EPGP-LDEIQIATILREILKGLDYLHSEKK---IHRDIKAANVLLSEHGEVKLADFGVAG 167 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 Q D ++ +GT + APE K+D++S G+ +EL G P P Sbjct: 168 QLTD--TQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHP 224
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 71.6 bits (174), Expect = 1e-12 Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 3/111 (2%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN---LLNQAPDMAAR 291 +++A++ ++G+EYLH + +IHRD++S+N+LL ++ + K+ADF L Q + Sbjct: 190 LRLALDISRGMEYLHSQ---GVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGN 246 Query: 292 LHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + GT+ + APE T+K DVYSFG+VL EL T P P Sbjct: 247 M------GTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTP 291
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 70.9 bits (172), Expect = 2e-12 Identities = 41/110 (37%), Positives = 61/110 (55%), Gaps = 8/110 (7%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK--------AKIADFNLLNQAP 276 V A++ A+G+ YLHE+ I+HRD++SSN+LL E + KI DF L + Sbjct: 238 VNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE-- 295 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 R GT+ + APE + ++ SD++S+GV+L ELLTG P Sbjct: 296 --WHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVP 343
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 70.9 bits (172), Expect = 2e-12 Identities = 40/114 (35%), Positives = 61/114 (53%), Gaps = 3/114 (2%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 + I + A+G++YLH K +IIHRD++S+N+ L ED KI DF L + + Sbjct: 526 IDIGRQVAQGMDYLHAK---NIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQA 582 Query: 301 TRVLGTFGYHAPEYAMTGQLTQ---KSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + G+ + APE +L +SDVY+FG+V+ ELL P H + Q Sbjct: 583 NQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQ 636
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 70.9 bits (172), Expect = 2e-12 Identities = 44/113 (38%), Positives = 59/113 (52%), Gaps = 11/113 (9%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFE--------DFKAKIADFNLLNQAP 276 V A++ A+G+ YLH IIHRD++S N+L+ E D KI DF L Sbjct: 197 VNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGL----- 251 Query: 277 DMAARLHSTRVL---GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 A H T + GT+ + APE ++ SDV+SFGV+L ELLTG P Sbjct: 252 --AREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVP 302
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 70.9 bits (172), Expect = 2e-12 Identities = 45/119 (37%), Positives = 63/119 (52%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 QP LD ++ V A+ AA + +HRD++ NVL+ +D + K+ADF L+ Sbjct: 114 QPRAALDILEPVLAALGAAH---------RAGFVHRDMKPENVLIGDDGRVKVADFGLV- 163 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 +A D T VLGT Y APE G + DVY+ G++L E+LTG KP D P Sbjct: 164 RAVDSVTNTTGT-VLGTVSYLAPEQIEHGTADPRVDVYACGILLYEMLTGEKPHDGDSP 221
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 70.9 bits (172), Expect = 2e-12 Identities = 43/119 (36%), Positives = 63/119 (52%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 +PGP LD Q I E KG++YLH + + IHRDI+++NVLL E + K+ADF + Sbjct: 124 EPGP-LDETQIATILREILKGLDYLHSEKK---IHRDIKAANVLLSEHGEVKLADFGVAG 179 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 Q D ++ +GT + APE K+D++S G+ +EL G P P Sbjct: 180 QLTD--TQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHP 236
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 70.1 bits (170), Expect(2) = 2e-12 Identities = 40/110 (36%), Positives = 60/110 (54%), Gaps = 8/110 (7%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK--------AKIADFNLLNQAP 276 V A++ A+G+ YLH++ IIHRD++SSN+L+ + + KI DF L + Sbjct: 243 VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE-- 300 Query: 277 DMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 R GT+ + APE ++ SDV+S+GV+L ELLTG P Sbjct: 301 --WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVP 348 Score = 20.8 bits (42), Expect(2) = 2e-12 Identities = 10/19 (52%), Positives = 12/19 (63%) Frame = +3 Query: 15 LAYEFATMGSLHDVLHGKK 71 L EFA G L+ VL GK+ Sbjct: 218 LVMEFARGGPLNRVLSGKR 236
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 68.9 bits (167), Expect(2) = 2e-12 Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 4/103 (3%) Frame = +1 Query: 130 AIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS--- 300 A + AKG+ YLH + +IHRD++S NV++ D KI DF A+R H+ Sbjct: 111 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG--------ASRFHNHTT 162 Query: 301 -TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 ++GTF + APE + +++ D YS+GVVL E+LT P Sbjct: 163 HMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVP 205 Score = 21.9 bits (45), Expect(2) = 2e-12 Identities = 9/23 (39%), Positives = 17/23 (73%) Frame = +3 Query: 3 NYRILAYEFATMGSLHDVLHGKK 71 NY I+ E+A++GSL+D ++ + Sbjct: 77 NYGIVT-EYASLGSLYDYINSNR 98
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 68.9 bits (167), Expect(2) = 2e-12 Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 4/103 (3%) Frame = +1 Query: 130 AIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS--- 300 A + AKG+ YLH + +IHRD++S NV++ D KI DF A+R H+ Sbjct: 111 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG--------ASRFHNHTT 162 Query: 301 -TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 ++GTF + APE + +++ D YS+GVVL E+LT P Sbjct: 163 HMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVP 205 Score = 21.9 bits (45), Expect(2) = 2e-12 Identities = 9/23 (39%), Positives = 17/23 (73%) Frame = +3 Query: 3 NYRILAYEFATMGSLHDVLHGKK 71 NY I+ E+A++GSL+D ++ + Sbjct: 77 NYGIVT-EYASLGSLYDYINSNR 98
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.5 bits (171), Expect = 3e-12 Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 6/131 (4%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 444 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV 465 + G+ + APE + +SDVYS+G+VL EL+ G P H R Q + Sbjct: 501 QVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFM 560 Query: 466 T---WATPRLS 489 +A+P LS Sbjct: 561 VGRGYASPDLS 571
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 70.5 bits (171), Expect = 3e-12 Identities = 40/106 (37%), Positives = 57/106 (53%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 + + I + I + H Q I+HRDI+ N+L+ K+ DF + A Sbjct: 110 EALNIMEQIVSAIAHAH---QNQIVHRDIKPHNILIDHMGNIKVTDFGIAT-ALSSTTIT 165 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 H+ VLG+ Y +PE A G T+KSD+Y+ G+VL ELLTGR P D Sbjct: 166 HTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFD 211
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 70.5 bits (171), Expect = 3e-12 Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 6/131 (4%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q + IA + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 119 QLIDIARQTAQGMDYLHAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 175 Query: 295 HSTRVLGTFGYHAPEYAM---TGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV 465 + G+ + APE + +SDVYS+G+VL EL+ G P H R Q + Sbjct: 176 QVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFM 235 Query: 466 T---WATPRLS 489 +A+P LS Sbjct: 236 VGRGYASPDLS 246
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 69.7 bits (169), Expect = 5e-12 Identities = 42/113 (37%), Positives = 62/113 (54%), Gaps = 11/113 (9%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKA--------KIADFNLLNQAP 276 V A++ A+G+ YLH + +IHRD++S+N+LL + ++ KI DF L Sbjct: 216 VNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGL----- 270 Query: 277 DMAARLHSTRVL---GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 A H T + GT+ + APE ++ SDV+SFGV+L ELLTG P Sbjct: 271 --AREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVP 321
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 69.7 bits (169), Expect = 5e-12 Identities = 35/104 (33%), Positives = 56/104 (53%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q ++I +A + + + H Q IIHRD++ +N+++ K+ DF + D + Sbjct: 114 QAIEIVADACQALNFSH---QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSTSVT 170 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + V+GT Y +PE A + +SDVYS G VL E+LTG P Sbjct: 171 QTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPP 214
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 65.9 bits (159), Expect(2) = 5e-12 Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 1/134 (0%) Frame = +1 Query: 76 VQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKA-KIAD 252 + GA+P P + ++ ++G+ YLH ++IHRD++ N+LL KI D Sbjct: 116 LHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICD 175 Query: 253 FNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 F A D+ + H T G+ + APE ++K DV+S+G++L E++T RKP D Sbjct: 176 FGT---ACDI--QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFD 230 Query: 433 HTMPRGQQSLVTWA 474 G + WA Sbjct: 231 EI--GGPAFRIMWA 242 Score = 23.9 bits (50), Expect(2) = 5e-12 Identities = 10/17 (58%), Positives = 13/17 (76%) Frame = +3 Query: 15 LAYEFATMGSLHDVLHG 65 L E+A GSL++VLHG Sbjct: 102 LVMEYAEGGSLYNVLHG 118
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 65.9 bits (159), Expect(2) = 5e-12 Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 1/134 (0%) Frame = +1 Query: 76 VQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKA-KIAD 252 + GA+P P + ++ ++G+ YLH ++IHRD++ N+LL KI D Sbjct: 116 LHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICD 175 Query: 253 FNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 F A D+ + H T G+ + APE ++K DV+S+G++L E++T RKP D Sbjct: 176 FGT---ACDI--QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFD 230 Query: 433 HTMPRGQQSLVTWA 474 G + WA Sbjct: 231 EI--GGPAFRIMWA 242 Score = 23.9 bits (50), Expect(2) = 5e-12 Identities = 10/17 (58%), Positives = 13/17 (76%) Frame = +3 Query: 15 LAYEFATMGSLHDVLHG 65 L E+A GSL++VLHG Sbjct: 102 LVMEYAEGGSLYNVLHG 118
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 68.9 bits (167), Expect = 8e-12 Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 D +Q + +A + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 402 DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS 458 Query: 286 ARLHSTRVLGTFGYHAPEYAMT---GQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + G+ + A E + +SDVY++GVVL EL+TG P H R Q Sbjct: 459 GAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQ 517
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 68.9 bits (167), Expect = 8e-12 Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 D +Q + +A + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 400 DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS 456 Query: 286 ARLHSTRVLGTFGYHAPEYAMT---GQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + G+ + A E + +SDVY++GVVL EL+TG P H R Q Sbjct: 457 GAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQ 515
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 68.9 bits (167), Expect = 8e-12 Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 D +Q + +A + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 400 DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS 456 Query: 286 ARLHSTRVLGTFGYHAPEYAMT---GQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + G+ + A E + +SDVY++GVVL EL+TG P H R Q Sbjct: 457 GAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQ 515
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 68.9 bits (167), Expect = 8e-12 Identities = 36/108 (33%), Positives = 61/108 (56%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 + I I+ AK +E H+ IIHRD++ N+L+ E+ K+ DF + ++ D + H+ Sbjct: 111 ISIGIKVAKALECAHKS---GIIHRDVKPQNILVTEEGVVKVTDFGIA-KSMDSSTIAHT 166 Query: 301 TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 V+G+ Y +PE A ++D+YS G+VL E++TG P + P Sbjct: 167 NSVMGSAHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTGVVPFNGDSP 214
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 68.2 bits (165), Expect = 1e-11 Identities = 41/120 (34%), Positives = 66/120 (55%), Gaps = 1/120 (0%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E KG+++LH K +IHRDI+S N+LL D KI DF Q ++ ++ ++G Sbjct: 1056 ETLKGLKFLHSK---GVIHRDIKSDNILLNMDGNIKITDFGFCAQINEINSK--RITMVG 1110 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP-VDHTMPRGQQSLVTWATPRLSE 492 T + APE + K DV+S G++++E+L G P ++ T R + T TP+L + Sbjct: 1111 TPYWMAPEIVSRKEYGPKVDVWSLGIMIIEMLEGEPPYLNETPLRALYLIATNGTPKLKD 1170
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 68.2 bits (165), Expect = 1e-11 Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +1 Query: 106 DWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 D +Q + +A + A+G++YLH K +IIHRD++S+N+ L E KI DF L + Sbjct: 402 DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS 458 Query: 286 ARLHSTRVLGTFGYHAPEYAMT---GQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQ 453 + G+ + A E + +SDVY++GVVL EL+TG P H R Q Sbjct: 459 GAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQ 517
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 68.2 bits (165), Expect = 1e-11 Identities = 39/120 (32%), Positives = 65/120 (54%), Gaps = 1/120 (0%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E G+E+LH K ++HRDI+S N+LL + K+ DF Q ++ L T ++G Sbjct: 722 ETLSGLEFLHSK---GVLHRDIKSDNILLSMEGDIKLTDFGFCAQINEL--NLKRTTMVG 776 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP-VDHTMPRGQQSLVTWATPRLSE 492 T + APE + K D++S G++++E++ G P ++ T R + T TP+L E Sbjct: 777 TPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKE 836
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 67.8 bits (164), Expect = 2e-11 Identities = 41/112 (36%), Positives = 60/112 (53%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P ++DW + A G+ YLH IIHRD++S N+L+ D KI+DF + Sbjct: 243 PSLLVDWSMGI------AGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE 293 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D + ++ GT + APE +++K D++SFGVVL ELLTG P Sbjct: 294 LSDKSTKMSFA---GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 342
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 67.8 bits (164), Expect = 2e-11 Identities = 41/112 (36%), Positives = 60/112 (53%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P ++DW + A G+ YLH IIHRD++S N+L+ D KI+DF + Sbjct: 243 PSLLVDWSMGI------AGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE 293 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D + ++ GT + APE +++K D++SFGVVL ELLTG P Sbjct: 294 LSDKSTKMSFA---GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 342
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 67.8 bits (164), Expect = 2e-11 Identities = 41/112 (36%), Positives = 60/112 (53%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P ++DW + A G+ YLH IIHRD++S N+L+ D KI+DF + Sbjct: 210 PSLLVDWSMGI------AGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE 260 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D + ++ GT + APE +++K D++SFGVVL ELLTG P Sbjct: 261 LSDKSTKMSFA---GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 309
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 67.4 bits (163), Expect = 2e-11 Identities = 40/105 (38%), Positives = 64/105 (60%), Gaps = 1/105 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q ++ A+ A+G+EYL K ++HRD+ + N+L+ ED AK++DF L ++ L Sbjct: 287 QLLQFALHVAEGMEYLESK---KLVHRDLAARNILVSEDLVAKVSDFGLAK--AELRKGL 341 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 S+R+ + APE G+ + KSDV+SFGV+L E+ + GR P Sbjct: 342 DSSRL--PVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAP 384
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 67.0 bits (162), Expect = 3e-11 Identities = 46/135 (34%), Positives = 73/135 (54%), Gaps = 5/135 (3%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK---AKIADFNL 261 PG L +Q++ A+G+ +H+K IIHRD++ NV + + + A++ DF + Sbjct: 109 PGRALPLLQQL------AEGLAAIHDK---GIIHRDLKPENVFISKSARGEQARLLDFGI 159 Query: 262 LNQA-PDMAARLHSTRV-LGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDH 435 PD A+ + V LGT Y +PE A+ ++ +SD+YSFGV+ +L+GR P D Sbjct: 160 ARLVEPDAASSVSQIGVVLGTPEYLSPEQAVGAKVDTRSDLYSFGVLTYRVLSGRLPFDG 219 Query: 436 TMPRGQQSLVTWATP 480 +PR S A P Sbjct: 220 PLPRNFLSQHASAAP 234
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 67.0 bits (162), Expect = 3e-11 Identities = 39/113 (34%), Positives = 62/113 (54%), Gaps = 4/113 (3%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L W R+ I I +K I YLH S+I I S+N+LL + F+ K+ DF + + + Sbjct: 262 LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHL 321 Query: 283 AARLHSTRVLGTFGYH----APEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 + + + + H EY G+L+ K+DVYSFG+V++E+LTG + V Sbjct: 322 EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVV 374
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 67.0 bits (162), Expect = 3e-11 Identities = 42/122 (34%), Positives = 62/122 (50%), Gaps = 3/122 (2%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL-HS 300 ++ + ++Y H IIHRDI+ N+++ E K+ DF + D AA + S Sbjct: 125 QVMLGVLNALDYSHRM---GIIHRDIKPGNIMISEQGVVKVMDFGIARALDDSAATMTQS 181 Query: 301 TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV--DHTMPRGQQSLVTWA 474 V+GT Y +PE A + +SD+YS G VL E+LTGR P D + Q + A Sbjct: 182 QGVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYEMLTGRPPFTGDSAVAIAYQHVSEVA 241 Query: 475 TP 480 TP Sbjct: 242 TP 243
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 66.6 bits (161), Expect = 4e-11 Identities = 36/82 (43%), Positives = 50/82 (60%), Gaps = 1/82 (1%) Frame = +1 Query: 184 IIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRV-LGTFGYHAPEYAMTGQL 360 ++HRD++ N+L+ +D K+ADF L+ AA + ST V LGT Y +PE G Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGLVRAVA--AASITSTGVILGTAAYLSPEQVRDGNA 195 Query: 361 TQKSDVYSFGVVLLELLTGRKP 426 +SDVYS GV++ ELLTG P Sbjct: 196 DPRSDVYSVGVLVYELLTGHTP 217
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 66.6 bits (161), Expect = 4e-11 Identities = 36/82 (43%), Positives = 50/82 (60%), Gaps = 1/82 (1%) Frame = +1 Query: 184 IIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRV-LGTFGYHAPEYAMTGQL 360 ++HRD++ N+L+ +D K+ADF L+ AA + ST V LGT Y +PE G Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGLVRAVA--AASITSTGVILGTAAYLSPEQVRDGNA 195 Query: 361 TQKSDVYSFGVVLLELLTGRKP 426 +SDVYS GV++ ELLTG P Sbjct: 196 DPRSDVYSVGVLVYELLTGHTP 217
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 66.6 bits (161), Expect = 4e-11 Identities = 39/118 (33%), Positives = 63/118 (53%), Gaps = 6/118 (5%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN--- 267 P + W R +I E A G+ YLH + P ++H D+++ N+LL +F KIADF L Sbjct: 114 PDIAWPLRFRILHEIALGVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRM 172 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQ---KSDVYSFGVVLLELLTGRKPVD 432 + + S GT Y PE GQ ++ K D+YS+ V++ E+L+ ++P + Sbjct: 173 MSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFE 230
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 66.6 bits (161), Expect = 4e-11 Identities = 41/112 (36%), Positives = 59/112 (52%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P ++DW + A G+ YLH IIHRD++S NVL+ KI+DF + Sbjct: 253 PRLLVDWSTGI------ASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKE 303 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D + ++ GT + APE +++K D++SFGVVL ELLTG P Sbjct: 304 LSDKSTKMSFA---GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 352
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 66.6 bits (161), Expect = 4e-11 Identities = 44/134 (32%), Positives = 69/134 (51%), Gaps = 1/134 (0%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 L+ Q I E KG+++LH+K IIHRDI+S NVLL KI DF + D Sbjct: 775 LNEKQIATICFETLKGLQHLHKK---HIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQ 831 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQS 459 R ++GT + APE + +K DV+S G++ +E++ G P + P + Sbjct: 832 --RNKRATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYL 889 Query: 460 LVTWATPRLSEDKV 501 + T TP+L + ++ Sbjct: 890 IATNGTPKLKKPEL 903
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 66.2 bits (160), Expect = 5e-11 Identities = 34/114 (29%), Positives = 66/114 (57%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM 282 +++ + + A + AK + + H+ I+HRDI+ N+++ +D K+ DF + +A + Sbjct: 105 IEFNKIIDYATQIAKALNFAHKN---GIVHRDIKPHNIMVTDDDIIKVTDFGIA-KASNE 160 Query: 283 AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 + + +V+G+ Y +PE A + ++D+YSFG+VL E+ TG+ P D P Sbjct: 161 STITTTNKVVGSAHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVPYDADTP 214
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 66.2 bits (160), Expect = 5e-11 Identities = 45/110 (40%), Positives = 60/110 (54%), Gaps = 1/110 (0%) Frame = +1 Query: 100 VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPD 279 VL Q V +A + A G+ YL Q + IHRD+ + N+L+ E K+ADF L + Sbjct: 330 VLKIEQLVDVAAQVASGMSYLE---QQNYIHRDLAARNILVGEHGICKVADFGLARVIDE 386 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 H T + APE AM + T KSDV+SFGVVL E++T GR P Sbjct: 387 EIYEAH-TGAKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYGRFP 435
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 66.2 bits (160), Expect = 5e-11 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 5/121 (4%) Frame = +1 Query: 85 AQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED---FKAKIADF 255 + P P L W R+ +A++ A+G+ YLH K + HRD+ S N L+ + F A + DF Sbjct: 142 SSPEP-LSWPVRLHLALDIARGLRYLHSK---GVFHRDLTSKNCLVRREDRGFTAVVGDF 197 Query: 256 NLLNQAPDM--AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 L + P AR V+G+ + APE +K+DV++FG+VL EL+ R P Sbjct: 198 GLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI-ARVPA 256 Query: 430 D 432 D Sbjct: 257 D 257
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 66.2 bits (160), Expect = 5e-11 Identities = 41/112 (36%), Positives = 59/112 (52%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P ++DW + A G+ YLH IIHRD++S NVL+ KI+DF + Sbjct: 253 PRLLVDWSTGI------ASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKE 303 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D + ++ GT + APE +++K D++SFGVVL ELLTG P Sbjct: 304 LSDKSTKMSFA---GTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 352
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 66.2 bits (160), Expect = 5e-11 Identities = 39/101 (38%), Positives = 56/101 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KIA +G+ YLHEK +IHRDI+ N+LL E+ + K+ DF + +A + A T Sbjct: 328 KIAEAVLRGLSYLHEK---KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLA----T 380 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 GT Y APE + SDV+S G+ +LE+ G+ P Sbjct: 381 TFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFP 421
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 65.9 bits (159), Expect = 7e-11 Identities = 41/105 (39%), Positives = 63/105 (60%), Gaps = 1/105 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q ++ A+ A+G+EYL K ++HRD+ + N+L+ ED AK++DF L A L Sbjct: 326 QLLQFALHVAEGMEYLESK---KLVHRDLAARNILVSEDLVAKVSDFGL---AKAERKGL 379 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 S+R+ + APE G+ + KSDV+SFGV+L E+ + GR P Sbjct: 380 DSSRL--PVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAP 422
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 65.9 bits (159), Expect = 7e-11 Identities = 43/147 (29%), Positives = 78/147 (53%), Gaps = 11/147 (7%) Frame = +1 Query: 19 HMNLQQWVLF----TMFCMXRKGVQGAQPGPVLDWMQRVK------IAIEAAKGIEYLHE 168 H+N+ Q++ F ++ + + V G G ++ R + + KG+ YLH Sbjct: 1237 HLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHS 1296 Query: 169 KVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAM 348 K I+HRD+++ N+LL +D KI+DF + ++ D+ + T + GT + APE Sbjct: 1297 K---GILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMT-MRGTVFWMAPEMVD 1352 Query: 349 TGQ-LTQKSDVYSFGVVLLELLTGRKP 426 T Q + K D++S G ++LE+ G++P Sbjct: 1353 TKQGYSAKVDIWSLGCIVLEMFAGKRP 1379
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 65.9 bits (159), Expect = 7e-11 Identities = 42/126 (33%), Positives = 66/126 (52%), Gaps = 1/126 (0%) Frame = +1 Query: 127 IAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTR 306 I E +G+++LH+K IIHRDI+S NVLL + KI DF + D R Sbjct: 624 IVRETCQGLKFLHDK---HIIHRDIKSDNVLLDTHGRVKITDFGFCAKLTD--KRSKRAT 678 Query: 307 VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQSLVTWATPR 483 ++GT + APE + +K DV+S G++ +E+L G P + P + + T TP+ Sbjct: 679 MVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLEGEPPYLNEEPLKALYLIATNGTPK 738 Query: 484 LSEDKV 501 L ++ Sbjct: 739 LKHPEL 744
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 65.9 bits (159), Expect = 7e-11 Identities = 39/118 (33%), Positives = 64/118 (54%), Gaps = 6/118 (5%) Frame = +1 Query: 97 PVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAP 276 P + W R +I E A G+ YLH + P ++H D+++ N+LL +F KIADF L Sbjct: 114 PDVAWPLRFRILHEIALGVNYLHN-MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRM 172 Query: 277 DMAARLHSTRVL---GTFGYHAPEYAMTGQLTQ---KSDVYSFGVVLLELLTGRKPVD 432 ++ S++ GT Y PE GQ ++ K D+YS+ V+ E+L+ ++P + Sbjct: 173 MSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE 230
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 65.9 bits (159), Expect = 7e-11 Identities = 36/102 (35%), Positives = 59/102 (57%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 +I++ +G+ YL ++++ I+HRD++ SN+L+ + + K+ DF + D A Sbjct: 173 RISVAVVRGLTYLKDEIK--ILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMAN---- 226 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y APE T SD++SFG+ L+ELL GR PV Sbjct: 227 SFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPV 268
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 65.5 bits (158), Expect = 9e-11 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 5/121 (4%) Frame = +1 Query: 85 AQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED---FKAKIADF 255 + P P L W R+ +A++ A+G+ YLH K + HRD+ S N L+ + F A + DF Sbjct: 137 SSPEP-LSWPVRLHLALDIAQGLRYLHAK---GVFHRDLTSKNCLVRREDGGFTAVVGDF 192 Query: 256 NLLNQAPDM--AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 L + P AR V+G+ + APE +K+DV++FG+VL EL+ R P Sbjct: 193 GLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI-ARVPA 251 Query: 430 D 432 D Sbjct: 252 D 252
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 65.5 bits (158), Expect = 9e-11 Identities = 43/115 (37%), Positives = 61/115 (53%), Gaps = 3/115 (2%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNL-- 261 QP W ++ E G+ YLH + PS++HRD++ SNVLL + AK+ADF L Sbjct: 108 QPSCPRPWPLLCRLLEEVVLGMCYLHS-LNPSLLHRDLKPSNVLLDLELHAKLADFGLST 166 Query: 262 LNQAPDMAARLHSTRVLGTFGYHAPEYA-MTGQLTQKSDVYSFGVVLLELLTGRK 423 + S GT Y APE G+ ++ SDVYSFGV++ +L GR+ Sbjct: 167 FQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGRE 221
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 65.5 bits (158), Expect = 9e-11 Identities = 41/105 (39%), Positives = 63/105 (60%), Gaps = 1/105 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q ++ ++ A+G+EYL K ++HRD+ + N+L+ ED AK++DF L A L Sbjct: 328 QLLQFSLHVAEGMEYLESK---KLVHRDLAARNILVSEDLVAKVSDFGL---AKAERKGL 381 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 S+R+ + APE G+ T KSDV+SFGV+L E+ + GR P Sbjct: 382 DSSRL--PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAP 424
>STK25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 65.1 bits (157), Expect = 1e-10 Identities = 49/157 (31%), Positives = 75/157 (47%), Gaps = 10/157 (6%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 +PGP L+ I E KG++YLH + + IHRDI+++NVLL E K+ADF + Sbjct: 108 KPGP-LEETYIATILREILKGLDYLHSERK---IHRDIKAANVLLSEQGDVKLADFGVAG 163 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPR 447 Q D ++ +GT + APE K+D++S G+ +EL G P P Sbjct: 164 QLTD--TQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPM 221 Query: 448 GQQSLVTWATPRLSEDK--------VKQCV--DPRLK 528 L+ +P E + V+ C+ DPR + Sbjct: 222 RVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFR 258
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 65.1 bits (157), Expect = 1e-10 Identities = 42/121 (34%), Positives = 64/121 (52%), Gaps = 1/121 (0%) Frame = +1 Query: 127 IAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTR 306 I E +G+++LH+K IIHRDI+S NVLL + KI DF + D R Sbjct: 673 IVRETCQGLKFLHDK---HIIHRDIKSDNVLLDTRARVKITDFGFCARLTD--KRSKRAT 727 Query: 307 VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQSLVTWATPR 483 ++GT + APE + +K DV+S G++ +E+L G P + P + + T TP+ Sbjct: 728 MVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPK 787 Query: 484 L 486 L Sbjct: 788 L 788
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 64.7 bits (156), Expect = 2e-10 Identities = 51/150 (34%), Positives = 75/150 (50%), Gaps = 11/150 (7%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ ++ KIADF L Sbjct: 357 GRYLKLPQLVDMAAQIAAGMAYIERM---NYIHRDLRAANILVGDNLVCKIADFGLARLI 413 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP------ 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 414 EDNE---YTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTELVTKGRVPYPGMNN 470 Query: 427 --VDHTMPRGQQSLVTWATPRLSEDKVKQC 510 V + RG + P D + QC Sbjct: 471 REVLEQVERGYRMQCPGGCPPSLHDVMVQC 500
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 64.7 bits (156), Expect = 2e-10 Identities = 39/111 (35%), Positives = 58/111 (52%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 GP D Q + E KG++YLH + + IHRDI+++NVLL E K+ADF + Q Sbjct: 114 GP-FDEFQIATMLKEILKGLDYLHSEKK---IHRDIKAANVLLSEQGDVKLADFGVAGQL 169 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D ++ +GT + APE K+D++S G+ +EL G P Sbjct: 170 TD--TQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPP 218
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 64.7 bits (156), Expect = 2e-10 Identities = 39/111 (35%), Positives = 58/111 (52%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 GP D Q + E KG++YLH + + IHRDI+++NVLL E K+ADF + Q Sbjct: 114 GP-FDEFQIATMLKEILKGLDYLHSEKK---IHRDIKAANVLLSEQGDVKLADFGVAGQL 169 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 D ++ +GT + APE K+D++S G+ +EL G P Sbjct: 170 TD--TQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPP 218
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 64.7 bits (156), Expect = 2e-10 Identities = 44/114 (38%), Positives = 65/114 (57%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ ++ KIADF L Sbjct: 355 GKFLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGDNLVCKIADFGLARLI 411 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 412 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 462
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 64.7 bits (156), Expect = 2e-10 Identities = 44/114 (38%), Positives = 65/114 (57%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ ++ KIADF L Sbjct: 362 GKFLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGDNLVCKIADFGLARLI 418 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 419 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 469
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 64.7 bits (156), Expect = 2e-10 Identities = 38/111 (34%), Positives = 58/111 (52%), Gaps = 1/111 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 + +++ E G+ H + ++HRDI+ N+L+ + +I DF L A A L Sbjct: 116 ETLRVVAETLDGLASAH---RAGVVHRDIKPENILINDRGHVQITDFGLAKAASQ--ATL 170 Query: 295 HST-RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 ST +LGT Y APE Q T + D+YS G++ E+LTG+ P D P Sbjct: 171 SSTGMLLGTAAYLAPEMIENNQATAQGDLYSVGIMAWEMLTGKVPFDSDNP 221
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 64.7 bits (156), Expect = 2e-10 Identities = 37/102 (36%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I +G+ YL EK Q I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 172 KVSIAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 225 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y APE + +SD++S G+ L+EL GR P+ Sbjct: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPI 267
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 64.7 bits (156), Expect = 2e-10 Identities = 32/102 (31%), Positives = 56/102 (54%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +K +++ G+ +LH + SI+H D++ +N+L+ E KI+DF + D+ R Sbjct: 176 LKYSLDVVNGLLFLHSQ---SILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQSP 232 Query: 301 TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + GT+ + APE T K+D+YSFG+ L ++ T P Sbjct: 233 HHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVP 274
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 64.7 bits (156), Expect = 2e-10 Identities = 43/114 (37%), Positives = 65/114 (57%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V++A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 351 GKYLRLPQLVEMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 407 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 408 EDNE---YTARPGARFPVKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 458
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 64.7 bits (156), Expect = 2e-10 Identities = 45/116 (38%), Positives = 65/116 (56%), Gaps = 3/116 (2%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 Q G L Q V +A + A+G+ Y+ IHRD+R++N+L+ E KIADF L Sbjct: 372 QEGQDLTLPQLVDMAAQVAEGMAYMERM---DYIHRDLRAANILVGERLVCKIADFGLAR 428 Query: 268 QAPDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL++ GR P Sbjct: 429 LIEDNE---YNPRQGAKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELISKGRVP 481
>PKNF_MYCTU (P72003) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 64.7 bits (156), Expect = 2e-10 Identities = 41/153 (26%), Positives = 68/153 (44%), Gaps = 4/153 (2%) Frame = +1 Query: 61 MXRKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFE---- 228 + R PGP + +I A+ ++Y HE+ ++HRD++ +N+L+ Sbjct: 100 LLRDRYPNGMPGPEV-----TEIITAVAEALDYAHER---RLLHRDVKPANILIANPDSP 151 Query: 229 DFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLEL 408 D + +ADF + D + + +GT Y APE M +L ++D Y+ L Sbjct: 152 DRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHL 211 Query: 409 LTGRKPVDHTMPRGQQSLVTWATPRLSEDKVKQ 507 LTG P H P S A+P D+V + Sbjct: 212 LTGSPPFQHANPAVVISQHLSASPPAIGDRVPE 244
>PKNF_MYCBO (Q7TZN1) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 64.7 bits (156), Expect = 2e-10 Identities = 41/153 (26%), Positives = 68/153 (44%), Gaps = 4/153 (2%) Frame = +1 Query: 61 MXRKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFE---- 228 + R PGP + +I A+ ++Y HE+ ++HRD++ +N+L+ Sbjct: 100 LLRDRYPNGMPGPEV-----TEIITAVAEALDYAHER---RLLHRDVKPANILIANPDSP 151 Query: 229 DFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLEL 408 D + +ADF + D + + +GT Y APE M +L ++D Y+ L Sbjct: 152 DRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHL 211 Query: 409 LTGRKPVDHTMPRGQQSLVTWATPRLSEDKVKQ 507 LTG P H P S A+P D+V + Sbjct: 212 LTGSPPFQHANPAVVISQHLSASPPAIGDRVPE 244
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 64.3 bits (155), Expect = 2e-10 Identities = 43/116 (37%), Positives = 65/116 (56%), Gaps = 3/116 (2%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 + G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 355 ETGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLAR 411 Query: 268 QAPDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 412 LIEDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 464
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 1/103 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +++ I + +EY H + I+HRDI+ +NV+L + + K+ DF + D + Sbjct: 116 LEMTIGILQALEYSH---RAGIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQ 172 Query: 301 TR-VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T V+GT Y +PE A Q+ +SD+YS G +L ELLT R P Sbjct: 173 TAAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPP 215
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 64.3 bits (155), Expect = 2e-10 Identities = 44/114 (38%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L V +A + A G+ Y+ + IHRD+RS+N+L+ ++ KIADF L Sbjct: 358 GRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANILVGDNLVCKIADFGLARLI 414 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 415 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/97 (38%), Positives = 55/97 (56%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 +AA G+ +H ++HRDI+ N+L+ + KI DF + A + + V+G Sbjct: 131 QAAHGLSVIHRM---GLVHRDIKPGNMLITANGILKITDFGIAKAAASVPLT-RTGMVVG 186 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y +PE A Q+T SDVYS GVV E+L+GR+P Sbjct: 187 TAQYVSPEQAQGHQVTPASDVYSLGVVGYEMLSGRRP 223
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/120 (33%), Positives = 65/120 (54%), Gaps = 14/120 (11%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN---------LLNQAP 276 +I +EA +G+ YLH+K +IH+D++ N+L+ DF KIAD L + Sbjct: 117 RIIVEAIEGMCYLHDK---GVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKD 173 Query: 277 DMAARLHSTRVL---GTFGYHAPEYA--MTGQLTQKSDVYSFGVVLLELLTGRKPVDHTM 441 + + ST GT Y APE+ + + T+KSDVYSFG+VL + ++P ++ + Sbjct: 174 NKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVI 233
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 63.9 bits (154), Expect = 3e-10 Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 1/109 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +++ +A + + + H Q IIHRD++ +N+++ K+ DF + D + Sbjct: 116 IEVIADACQALNFSH---QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQ 172 Query: 301 TR-VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 T V+GT Y +PE A + +SDVYS G VL E+LTG P P Sbjct: 173 TAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSP 221
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 63.9 bits (154), Expect = 3e-10 Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 1/109 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +++ +A + + + H Q IIHRD++ +N+++ K+ DF + D + Sbjct: 116 IEVIADACQALNFSH---QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQ 172 Query: 301 TR-VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 T V+GT Y +PE A + +SDVYS G VL E+LTG P P Sbjct: 173 TAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSP 221
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/111 (35%), Positives = 56/111 (50%), Gaps = 6/111 (5%) Frame = +1 Query: 124 KIAIEAAKGIEYLHE-----KVQP-SIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMA 285 K+ AA+G+ Y HE +P +IHRD+ N+L+ K+ DF + A Sbjct: 113 KVVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKVVDFGIAKVA-GQG 171 Query: 286 ARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHT 438 R + V G Y PE + ++ DVY+ GVVL ELLTG++P D T Sbjct: 172 HRTLTGVVKGKVAYMPPEQLQAKAMDRRVDVYALGVVLYELLTGKRPFDAT 222
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/97 (40%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A +++LH II+RD++ N+LL E+ KI DF L +A D R +S G Sbjct: 167 ELALALDHLHGL---GIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYS--FCG 221 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE TQ +D +SFGV++ E+LTG P Sbjct: 222 TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLP 258 Score = 38.5 bits (88), Expect = 0.012 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 4/99 (4%) Frame = +1 Query: 142 AKGIEYLHEKVQPSIIHRDIRSSNVLLFEDF----KAKIADFNLLNQAPDMAARLHSTRV 309 A+ ++YLH + ++HRD++ SN+L ++ +I DF Q L + Sbjct: 517 ARTMDYLHSQ---GVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCY 573 Query: 310 LGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE DV+S G++L +L G P Sbjct: 574 --TANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTP 610
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/97 (40%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A +++LH II+RD++ N+LL E+ KI DF L +A D R +S G Sbjct: 167 ELALALDHLHSL---GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYS--FCG 221 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE TQ +D +SFGV++ E+LTG P Sbjct: 222 TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLP 258 Score = 35.8 bits (81), Expect = 0.079 Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 4/98 (4%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDF----KAKIADFNLLNQAPDMAARLHSTRVL 312 K ++YLH + ++HRD++ SN+L ++ ++ DF Q L + Sbjct: 518 KTMDYLHSQ---GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTP--C 572 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE D++S G++L +L G P Sbjct: 573 YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 610
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/113 (35%), Positives = 60/113 (53%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 +PGP L+ I E KG++YLH + + IHRDI+++NVLL E K+ADF + Sbjct: 108 KPGP-LEETYIATILREILKGLDYLHSERK---IHRDIKAANVLLSEQGDVKMADFGVAG 163 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 Q D ++ +GT + APE K+D++S G+ +EL G P Sbjct: 164 QLTD--TQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP 214
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 63.9 bits (154), Expect = 3e-10 Identities = 33/100 (33%), Positives = 54/100 (54%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q V + E ++G+ YL + ++HRD+R+ N+L+ D K+ADF L Sbjct: 318 QMVHMMAEISEGMAYLESE---KVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQ 374 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 + + + APE A + T KSDV+S+G+V+ E+LT Sbjct: 375 EKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILT 414
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>PKSC_STRCO (Q9S2C0) Serine/threonine protein kinase pksC (EC 2.7.11.1)| Length = 556 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/123 (31%), Positives = 62/123 (50%), Gaps = 1/123 (0%) Frame = +1 Query: 79 QGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN 258 QGA P + +KI + +E HE ++HRDI+ NV++ + K+ DF Sbjct: 120 QGAMPAD-----KALKITADVLAALEISHEM---GLVHRDIKPGNVMMTKRGVVKVMDFG 171 Query: 259 LLNQAPDMAARLHST-RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDH 435 + + T V+GT Y +PE A+ + +SD+YS G++L +L+TGR P D Sbjct: 172 IARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVTGRLPFDA 231 Query: 436 TMP 444 P Sbjct: 232 DSP 234
>E2AK2_HUMAN (P19525) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) Length = 551 Score = 63.9 bits (154), Expect = 3e-10 Identities = 35/106 (33%), Positives = 59/106 (55%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G LD + +++ + KG++Y+H K +IHRD++ SN+ L + + KI DF L+ Sbjct: 383 GEKLDKVLALELFEQITKGVDYIHSK---KLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELL 411 + R TR GT Y +PE + ++ D+Y+ G++L ELL Sbjct: 440 KNDGKR---TRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 482
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 354 GKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 410 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 411 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 63.9 bits (154), Expect = 3e-10 Identities = 42/121 (34%), Positives = 64/121 (52%), Gaps = 5/121 (4%) Frame = +1 Query: 85 AQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED---FKAKIADF 255 + P P L W R+ +A++ A+G+ YLH K + HRD+ S N L+ + F A + DF Sbjct: 137 SSPEP-LSWPVRLHLALDIAQGLRYLHAK---GVFHRDLTSKNCLVRREDRGFTAVVGDF 192 Query: 256 NLLNQAPDM--AARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 L + P R V+G+ + APE +K+DV++FG+VL EL+ R P Sbjct: 193 GLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI-ARVPA 251 Query: 430 D 432 D Sbjct: 252 D 252
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 63.5 bits (153), Expect = 4e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 353 GRYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 409 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 410 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 460
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 63.5 bits (153), Expect = 4e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 353 GRYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLI 409 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 410 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 460
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 63.5 bits (153), Expect = 4e-10 Identities = 44/114 (38%), Positives = 63/114 (55%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L V +A + A+G+ Y+ + IHRD+RS+N+L+ KIADF L Sbjct: 358 GRALKLPNLVDMAAQVARGMAYIERM---NYIHRDLRSANILVGNGLICKIADFGLARLI 414 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 415 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 63.5 bits (153), Expect = 4e-10 Identities = 49/150 (32%), Positives = 76/150 (50%), Gaps = 11/150 (7%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ ++ + IHRD+R++N+L+ ++ KIADF L Sbjct: 365 GKHLKLPQLVDMASQIADGMAFIERM---NYIHRDLRAANILVADNLVCKIADFGLARLI 421 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP------ 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 422 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVN 478 Query: 427 --VDHTMPRGQQSLVTWATPRLSEDKVKQC 510 V + RG + P + ++QC Sbjct: 479 REVLEQVDRGYRMPCPQGCPESLHEMMRQC 508
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 63.5 bits (153), Expect = 4e-10 Identities = 44/114 (38%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ E+ KIADF L Sbjct: 364 GKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGENLVCKIADFGLARLI 420 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++ EL+T GR P Sbjct: 421 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP 471
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 63.2 bits (152), Expect = 5e-10 Identities = 36/102 (35%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I +G+ YL EK Q I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 172 KVSIAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 225 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+EL GR P+ Sbjct: 226 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPI 267
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 63.2 bits (152), Expect = 5e-10 Identities = 44/114 (38%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ E+ KIADF L Sbjct: 362 GKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGENLICKIADFGLARLI 418 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++ EL+T GR P Sbjct: 419 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP 469
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 63.2 bits (152), Expect = 5e-10 Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 3/116 (2%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 + G L Q V ++ + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 360 ETGKYLRLPQLVDMSAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLAR 416 Query: 268 QAPDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 417 LIEDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 469
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 63.2 bits (152), Expect = 5e-10 Identities = 36/102 (35%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I +G+ YL EK Q I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 172 KVSIAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 225 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+EL GR P+ Sbjct: 226 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPI 267
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 63.2 bits (152), Expect = 5e-10 Identities = 32/102 (31%), Positives = 56/102 (54%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +K +++ G+ +LH + SI+H D++ +N+L+ E KI+DF + D+ R Sbjct: 174 LKYSLDIVNGLLFLHSQ---SILHLDLKPANILISEKDVCKISDFGCSQKLQDLRCRPSL 230 Query: 301 TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + GT+ + APE T K+D+YSFG+ L ++ T P Sbjct: 231 HHIGGTYTHQAPELLKGEIATPKADIYSFGITLWQMTTREVP 272
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 62.8 bits (151), Expect = 6e-10 Identities = 37/102 (36%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I +G+ YL EK Q I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 169 KVSIAVLRGLVYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 222 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SDV+S G+ L+EL GR P+ Sbjct: 223 SFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRFPI 264
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 62.8 bits (151), Expect = 6e-10 Identities = 43/114 (37%), Positives = 64/114 (56%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ ++ KIADF L Sbjct: 358 GKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGDNLVCKIADFGLARLI 414 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+ GR P Sbjct: 415 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVAKGRVP 465
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 62.8 bits (151), Expect = 6e-10 Identities = 44/114 (38%), Positives = 63/114 (55%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L Q V +A + A G+ Y+ + IHRD+R++N+L+ E+ KIADF L Sbjct: 360 GKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGENLVCKIADFGLARLI 416 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++ EL T GR P Sbjct: 417 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELTTKGRVP 467
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 62.8 bits (151), Expect = 6e-10 Identities = 36/102 (35%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I +G+ YL EK Q I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 170 KVSIAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 223 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+EL GR P+ Sbjct: 224 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPI 265
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 62.8 bits (151), Expect = 6e-10 Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 3/116 (2%) Frame = +1 Query: 88 QPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLN 267 + G L Q V ++ + A G+ Y+ + +HRD+R++N+L+ E+ K+ADF L Sbjct: 355 ETGKYLRLPQLVDMSAQIASGMAYVDRM---NYVHRDLRAANILVGENLVCKVADFGLAR 411 Query: 268 QAPDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL T GR P Sbjct: 412 LIEDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 464
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 55.5 bits (132), Expect(2) = 7e-10 Identities = 37/137 (27%), Positives = 66/137 (48%), Gaps = 10/137 (7%) Frame = +1 Query: 130 AIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK-AKIADFNLLNQAPDMAARLHSTR 306 A + A+G+ YLH +IHRD++ N+LL + KI DF + M T Sbjct: 118 ARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTM-----MTN 172 Query: 307 VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP---------VDHTMPRGQQS 459 G+ + APE + T+K D++S+ +VL E+L+ ++P + + +G++ Sbjct: 173 NRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP 232 Query: 460 LVTWATPRLSEDKVKQC 510 + P+ ED + C Sbjct: 233 PLLTTCPKRIEDLMTAC 249 Score = 26.9 bits (58), Expect(2) = 7e-10 Identities = 12/18 (66%), Positives = 13/18 (72%) Frame = +3 Query: 15 LAYEFATMGSLHDVLHGK 68 L EFA GSLH+ LHGK Sbjct: 87 LIMEFAEGGSLHNFLHGK 104
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 62.4 bits (150), Expect = 8e-10 Identities = 38/103 (36%), Positives = 55/103 (53%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KIA +G+ YLHE+ +IHRDI+ N+LL E + K+ DF + +A + A + Sbjct: 321 KIAESVLRGLSYLHER---KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFT- 376 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 GT Y APE + DV+S G+ LLE+ GR P + Sbjct: 377 ---GTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFE 416
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 62.4 bits (150), Expect = 8e-10 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 168 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 221 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/114 (38%), Positives = 62/114 (54%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L V +A + A G+ Y+ + IHRD+RS+N+L+ KIADF L Sbjct: 358 GRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANILVGNGLICKIADFGLARLI 414 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 415 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 62.4 bits (150), Expect = 8e-10 Identities = 37/101 (36%), Positives = 53/101 (52%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KIA G+ YLH++ IIHRDI+ SN+LL + K+ DF + + + A + Sbjct: 185 KIAFGVLSGLSYLHDR---KIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSLAGTFT- 240 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 GT Y APE G T SD++S G+ L+E+ R P Sbjct: 241 ---GTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFP 278
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 62.4 bits (150), Expect = 8e-10 Identities = 40/103 (38%), Positives = 58/103 (56%), Gaps = 1/103 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 V +A + A+G+ Y+ + IHRD+R++N+L+ E KIADF L D Sbjct: 348 VDMAAQVAEGMAYMERM---NYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQ 404 Query: 301 TRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 405 GTKF-PIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVP 446
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/114 (38%), Positives = 62/114 (54%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L V +A + A G+ Y+ + IHRD+RS+N+L+ KIADF L Sbjct: 355 GRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANILVGNGLICKIADFGLARLI 411 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 412 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 462
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/114 (38%), Positives = 62/114 (54%), Gaps = 3/114 (2%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQA 273 G L V +A + A G+ Y+ + IHRD+RS+N+L+ KIADF L Sbjct: 355 GRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANILVGNGLICKIADFGLARLI 411 Query: 274 PDMAARLHSTRVLGTFG--YHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 D ++ R F + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 412 EDNE---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 462
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 62.4 bits (150), Expect = 8e-10 Identities = 41/105 (39%), Positives = 59/105 (56%), Gaps = 1/105 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q V +A + A+G+ Y+ + IHRD+R++N+L+ E KIADF L D Sbjct: 358 QLVDMAAQVAEGMAYMERM---NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNP 414 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKP 426 + APE A+ G+ T KSDV+SFG++L EL+T GR P Sbjct: 415 CQGSKF-PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIP 458
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 62.4 bits (150), Expect = 8e-10 Identities = 37/111 (33%), Positives = 55/111 (49%), Gaps = 1/111 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q I I ++ HE IIHRD++ +N+++ K+ DF + D + + Sbjct: 112 QAATIMIPVCHALQSSHEA---GIIHRDVKPANIMINNTGGVKVMDFGIARALDDSTSAM 168 Query: 295 HSTR-VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 T V+GT Y +PE A +SDVY+ G VL EL+TGR P + P Sbjct: 169 TQTAAVIGTAQYLSPEQARGKPADARSDVYAAGCVLYELVTGRPPFEGESP 219
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.4 bits (150), Expect = 8e-10 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 220 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.4 bits (150), Expect = 8e-10 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 220 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.4 bits (150), Expect = 8e-10 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 220 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.4 bits (150), Expect = 8e-10 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 220 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 62.4 bits (150), Expect = 8e-10 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 3/123 (2%) Frame = +1 Query: 76 VQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIAD- 252 +QG L W QRV I +EYLH IIH +++SSNVLL ++ K+A Sbjct: 298 LQGQGGSDPLPWPQRVSICSGLLCAVEYLHGL---EIIHSNVKSSNVLLDQNLTPKLAHP 354 Query: 253 -FNLLNQAPDMAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 +L + T +L T + PE + GQLT++ D++S G+VL E+LTG Sbjct: 355 MAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPA 414 Query: 427 VDH 435 +D+ Sbjct: 415 MDN 417
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 12/120 (10%) Frame = +1 Query: 109 WMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLL-------N 267 W QRV A + A G+ YLH +IIHRD+ S N L+ E+ +ADF L N Sbjct: 434 WSQRVSFAKDIASGMAYLHSM---NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKN 490 Query: 268 QAPDMAA-----RLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 Q+ D+ + R V+G + APE +K DV+SFG+VL E++ GR D Sbjct: 491 QSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549
>MP2K6_MOUSE (P70236) Dual specificity mitogen-activated protein kinase kinase 6| (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3) Length = 334 Score = 62.4 bits (150), Expect = 8e-10 Identities = 47/132 (35%), Positives = 69/132 (52%), Gaps = 7/132 (5%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KIA+ K +E+LH K+ S+IHRD++ SNVL+ + K+ DF + D A+ T Sbjct: 157 KIAVSIVKALEHLHSKL--SVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAK---T 211 Query: 304 RVLGTFGYHAPEYAMTGQLTQ-----KSDVYSFGVVLLELLTGRKPVDHTMPRGQQ--SL 462 G Y APE + +L Q KSD++S G+ ++EL R P D QQ + Sbjct: 212 IDAGCKPYMAPE-RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 Query: 463 VTWATPRLSEDK 498 V +P+L DK Sbjct: 271 VEEPSPQLPADK 282
>MP2K6_HUMAN (P52564) Dual specificity mitogen-activated protein kinase kinase 6| (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3) Length = 334 Score = 62.4 bits (150), Expect = 8e-10 Identities = 47/132 (35%), Positives = 69/132 (52%), Gaps = 7/132 (5%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KIA+ K +E+LH K+ S+IHRD++ SNVL+ + K+ DF + D A+ T Sbjct: 157 KIAVSIVKALEHLHSKL--SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK---T 211 Query: 304 RVLGTFGYHAPEYAMTGQLTQ-----KSDVYSFGVVLLELLTGRKPVDHTMPRGQQ--SL 462 G Y APE + +L Q KSD++S G+ ++EL R P D QQ + Sbjct: 212 IDAGCKPYMAPE-RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 Query: 463 VTWATPRLSEDK 498 V +P+L DK Sbjct: 271 VEEPSPQLPADK 282
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 220 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 221 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPI 262
>STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC 2.7.12.2)| Length = 515 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 6/132 (4%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KIA G+++L+ Q IIHRDI+ SNVL+ + K+ DF + + + A Sbjct: 309 KIAYGVLNGLDHLYR--QYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIA----D 362 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV--DHTMPRG----QQSLV 465 +GT Y +PE + K DV+S G++++EL+TG P+ + P G Q +V Sbjct: 363 TFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIV 422 Query: 466 TWATPRLSEDKV 501 +PRL +D++ Sbjct: 423 NEPSPRLPKDRI 434
>LRRK1_MOUSE (Q3UHC2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2014 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/113 (36%), Positives = 63/113 (55%), Gaps = 5/113 (4%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLF-----EDFKAKIADFNLLN 267 L M KIA + A G+ YLH+K +II D++S N+L++ E K++D+ + Sbjct: 1358 LGHMLTQKIAYQIASGLAYLHKK---NIIFCDLKSDNILVWSLSAKEHINIKLSDYGISR 1414 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 Q+ A V GT GY APE +K D++S+G+VL ELL+G++P Sbjct: 1415 QSFHEGA----LGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP 1463
>RON_HUMAN (Q04912) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Length = 1400 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/112 (37%), Positives = 59/112 (52%), Gaps = 4/112 (3%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM---AAR 291 + ++ A+G+EYL E+ +HRD+ + N +L E F K+ADF L D + + Sbjct: 1186 ISFGLQVARGMEYLAEQ---KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQ 1242 Query: 292 LHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKPVDHTMP 444 H L + A E T + T KSDV+SFGV+L ELLT G P H P Sbjct: 1243 QHRHARLPV-KWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDP 1293
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/134 (30%), Positives = 66/134 (49%), Gaps = 1/134 (0%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q I E +G+++LHE I+HRDI+S N+LL K+ DF Q + Sbjct: 481 QIAAICKETLEGLQHLHEN---GIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTK- 536 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQSLVTW 471 T ++GT + APE + K DV+S G++ +E++ G P + P R + T Sbjct: 537 -RTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATI 595 Query: 472 ATPRLSEDKVKQCV 513 TP++S ++ V Sbjct: 596 GTPKISRPELLSSV 609
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/132 (30%), Positives = 67/132 (50%), Gaps = 4/132 (3%) Frame = +1 Query: 133 IEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVL 312 ++ ++Y+H ++HRDI+S+NVLL K+ DF +Q D + + ++ Sbjct: 129 LQLCLALDYIHSH---KMLHRDIKSANVLLTSTGLVKLGDFGFSHQYEDTVSGVVASTFC 185 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVTWAT----P 480 GT Y APE + +K+DV+S GV+L E++ +KP + +G S V T P Sbjct: 186 GTPYYLAPELWNNKRYNKKADVWSLGVLLYEIMGMKKPFSASNLKGLMSKVLAGTYAPLP 245 Query: 481 RLSEDKVKQCVD 516 + K+ VD Sbjct: 246 DSFSSEFKRVVD 257
>RON_MOUSE (Q62190) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating prote Length = 1378 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 4/112 (3%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDM---AAR 291 V ++ A G+EYL E+ +HRD+ + N +L E F K+ADF L D + R Sbjct: 1163 VSFGLQVACGMEYLAEQ---KFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVR 1219 Query: 292 LHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKPVDHTMP 444 H L + A E T + T KSDV+SFGV+L ELLT G P H P Sbjct: 1220 QHRHARLPV-KWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDP 1270
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/108 (37%), Positives = 60/108 (55%), Gaps = 1/108 (0%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ- 270 G L + + IA + A G+EYL K +IHRD+ + NVL+ E+ AKI DF L Sbjct: 373 GRYLHFEDLIYIATQVASGMEYLESK---QLIHRDLAARNVLIGENNVAKICDFGLARVI 429 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 A D +R + APE + G+ + KSDV+S+G++L+EL T Sbjct: 430 ADDEYCPKQGSRF--PVKWTAPEAIIYGKFSIKSDVWSYGILLMELFT 475
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/103 (32%), Positives = 57/103 (55%), Gaps = 1/103 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +K +++ G+ +LH + SI+H D++ +N+L+ E KI+DF + D+ R S Sbjct: 207 LKYSLDVVNGLLFLHSQ---SILHLDLKPANILISEQDVCKISDFGCSQKLQDLRGRQAS 263 Query: 301 T-RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + GT+ + APE T K+D+YSFG+ L ++ T P Sbjct: 264 PPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVP 306
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/103 (32%), Positives = 57/103 (55%), Gaps = 1/103 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +K +++ G+ +LH + SI+H D++ +N+L+ E KI+DF + D+ R S Sbjct: 207 LKYSLDVVNGLLFLHSQ---SILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQAS 263 Query: 301 TRVLG-TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 +G T+ + APE T K+D+YSFG+ L ++ T P Sbjct: 264 PHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVP 306
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K++I KG+ YL EK + I+HRD++ SN+L+ + K+ DF + Q D A Sbjct: 161 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---- 214 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE + +SD++S G+ L+E+ GR P+ Sbjct: 215 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPI 256
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/103 (32%), Positives = 57/103 (55%), Gaps = 1/103 (0%) Frame = +1 Query: 121 VKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +K +++ G+ +LH + SI+H D++ +N+L+ E KI+DF + D+ R S Sbjct: 207 LKYSLDVVNGLLFLHSQ---SILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQAS 263 Query: 301 TRVLG-TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 +G T+ + APE T K+D+YSFG+ L ++ T P Sbjct: 264 PHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVP 306
>LRRK1_HUMAN (Q38SD2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2038 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/113 (36%), Positives = 63/113 (55%), Gaps = 5/113 (4%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLF-----EDFKAKIADFNLLN 267 L M KIA + A G+ YLH+K +II D++S N+L++ E K++D+ + Sbjct: 1381 LGHMLTQKIAYQIASGLAYLHKK---NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISR 1437 Query: 268 QAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 Q+ A V GT GY APE +K D++S+G+VL ELL+G++P Sbjct: 1438 QSFHEGA----LGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP 1486
>MP2K7_HUMAN (O14733) Dual specificity mitogen-activated protein kinase kinase 7| (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Length = 419 Score = 61.6 bits (148), Expect = 1e-09 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 5/125 (4%) Frame = +1 Query: 67 RKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKI 246 +K +QG P +L K+ + K + YL EK +IHRD++ SN+LL E + K+ Sbjct: 207 KKRMQGPIPERILG-----KMTVAIVKALYYLKEK--HGVIHRDVKPSNILLDERGQIKL 259 Query: 247 ADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQ-----KSDVYSFGVVLLELL 411 DF + + D A+ TR G Y APE T+ ++DV+S G+ L+EL Sbjct: 260 CDFGISGRLVDSKAK---TRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELA 316 Query: 412 TGRKP 426 TG+ P Sbjct: 317 TGQFP 321
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 4/120 (3%) Frame = +1 Query: 79 QGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN 258 +G VLD I E +G+EYLH+ Q IHRD+++ N+LL ED +IADF Sbjct: 110 KGEHKSGVLDESTIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFG 166 Query: 259 L---LNQAPDMAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + L D+ +GT + APE K+D++SFG+ +EL TG P Sbjct: 167 VSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAP 226
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 4/120 (3%) Frame = +1 Query: 79 QGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN 258 +G VLD I E +G+EYLH+ Q IHRD+++ N+LL ED +IADF Sbjct: 110 KGEHKSGVLDESTIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFG 166 Query: 259 L---LNQAPDMAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + L D+ +GT + APE K+D++SFG+ +EL TG P Sbjct: 167 VSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAP 226
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 4/120 (3%) Frame = +1 Query: 79 QGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN 258 +G VLD I E +G+EYLH+ Q IHRD+++ N+LL ED +IADF Sbjct: 110 KGEHKSGVLDEATIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFG 166 Query: 259 L---LNQAPDMAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + L D+ +GT + APE K+D++SFG+ +EL TG P Sbjct: 167 VSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAP 226
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 61.6 bits (148), Expect = 1e-09 Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 2/107 (1%) Frame = +1 Query: 109 WMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAA 288 W ++ E G+ YLH++ P ++HRD++ SNVL + K+ADF L + Sbjct: 114 WPLLCRLLKEVVLGMFYLHDQ-NPVLLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQS 172 Query: 289 RLHSTRVLGTFGYHAPE--YAMTGQLTQKSDVYSFGVVLLELLTGRK 423 S GT GY APE + + + SDVYSFG+++ +L GR+ Sbjct: 173 GTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE 219
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 61.6 bits (148), Expect = 1e-09 Identities = 38/111 (34%), Positives = 58/111 (52%) Frame = +1 Query: 82 GAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNL 261 G+ G L + A + A+G+ YL E+ ++HRD+ + NVL+ +D K+ADF L Sbjct: 319 GSSEGKALSLPHLLGFACQVAEGMSYLEER---RVVHRDLAARNVLVGDDLTCKVADFGL 375 Query: 262 LNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 D S + + APE A +QKSDV+SFG++L E+ T Sbjct: 376 ARLLKDDVYSPSSGSKI-PVKWTAPEAANYRVFSQKSDVWSFGILLYEVFT 425
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 61.6 bits (148), Expect = 1e-09 Identities = 43/125 (34%), Positives = 60/125 (48%) Frame = +1 Query: 52 MFCMXRKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED 231 +F + RK + P PV + A E +EYLH K II+RD++ N+LL ++ Sbjct: 173 LFSLLRKSQRF--PNPVAKFY-----AAEVCLALEYLHSK---DIIYRDLKPENILLDKN 222 Query: 232 FKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELL 411 KI DF PD+ L GT Y APE T + D +SFGV++ E+L Sbjct: 223 GHIKITDFGFAKYVPDVTYTL-----CGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEML 277 Query: 412 TGRKP 426 G P Sbjct: 278 AGYTP 282
>MP2K4_HUMAN (P45985) Dual specificity mitogen-activated protein kinase kinase 4| (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) Length = 399 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/105 (39%), Positives = 54/105 (51%), Gaps = 4/105 (3%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KI + K + +L E ++ IIHRDI+ SN+LL K+ DF + Q D A+ T Sbjct: 207 KITLATVKALNHLKENLK--IIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAK---T 261 Query: 304 RVLGTFGYHAPEYAMTGQLTQ----KSDVYSFGVVLLELLTGRKP 426 R G Y APE Q +SDV+S G+ L EL TGR P Sbjct: 262 RDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFP 306
>MP2K4_MOUSE (P47809) Dual specificity mitogen-activated protein kinase kinase 4| (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SE Length = 397 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/105 (39%), Positives = 54/105 (51%), Gaps = 4/105 (3%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KI + K + +L E ++ IIHRDI+ SN+LL K+ DF + Q D A+ T Sbjct: 205 KITLATVKALNHLKENLK--IIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAK---T 259 Query: 304 RVLGTFGYHAPEYAMTGQLTQ----KSDVYSFGVVLLELLTGRKP 426 R G Y APE Q +SDV+S G+ L EL TGR P Sbjct: 260 RDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFP 304
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/125 (33%), Positives = 60/125 (48%) Frame = +1 Query: 52 MFCMXRKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFED 231 +F + RK + P PV + A E +EYLH K II+RD++ N+LL ++ Sbjct: 172 LFSLLRKSQRF--PNPVAKFY-----AAEVCLALEYLHSK---DIIYRDLKPENILLDKN 221 Query: 232 FKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELL 411 KI DF PD+ L GT Y APE T + D +SFG+++ E+L Sbjct: 222 GHIKITDFGFAKYVPDVTYTL-----CGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEML 276 Query: 412 TGRKP 426 G P Sbjct: 277 AGYTP 281
>NRKB_TRYBB (Q03428) Putative serine/threonine-protein kinase B (EC 2.7.11.1)| Length = 431 Score = 61.2 bits (147), Expect = 2e-09 Identities = 40/132 (30%), Positives = 67/132 (50%), Gaps = 4/132 (3%) Frame = +1 Query: 133 IEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVL 312 ++ ++Y+H ++HRDI+S+NVLL K+ DF +Q D + + ++ Sbjct: 129 LQLCLALDYIHSH---KMLHRDIKSANVLLTSTGLVKLGDFGFSHQYEDTVSGVVASTFC 185 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVTWAT----P 480 GT Y APE + +K+DV+S GV+L E++ +KP + +G S V T P Sbjct: 186 GTPYYLAPELWNNLRYNKKADVWSLGVLLYEIMGMKKPFSASNLKGLMSKVLAGTYAPLP 245 Query: 481 RLSEDKVKQCVD 516 + K+ VD Sbjct: 246 DSFSSEFKRVVD 257
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 4/120 (3%) Frame = +1 Query: 79 QGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFN 258 +G VLD I E +G+EYLH+ Q IHRD+++ N+LL ED +IADF Sbjct: 110 KGEHKSGVLDEPTIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGSVQIADFG 166 Query: 259 L---LNQAPDMAARLHSTRVLGTFGYHAPE-YAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + L D+ +GT + APE K+D++SFG+ +EL TG P Sbjct: 167 VSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAP 226
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 61.2 bits (147), Expect = 2e-09 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 10/133 (7%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFG 324 KG+EYLH + IHRDI++ N+LL + AK+ADF + Q D A+ ++ V+GT Sbjct: 135 KGLEYLHFMRK---IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT--VIGTPF 189 Query: 325 YHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV------TWATPRL 486 + APE +D++S G+ +E+ G+ P P ++ T+ P L Sbjct: 190 WMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 249 Query: 487 SEDK----VKQCV 513 D VKQC+ Sbjct: 250 WSDNFTDFVKQCL 262
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 61.2 bits (147), Expect = 2e-09 Identities = 34/104 (32%), Positives = 56/104 (53%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q +I +E KGI++LH + +IIHRDI+S NVLL KI DF + + + Sbjct: 410 QIARICLETCKGIQHLHAR---NIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNK- 465 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 ++GT + APE + K D++S G++++E++ P Sbjct: 466 -RVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPP 508
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 61.2 bits (147), Expect = 2e-09 Identities = 33/106 (31%), Positives = 55/106 (51%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 + ++I E ++ H IIHRD++ NVL+ K+ DF + + + Sbjct: 112 EAIEIITEILSAMDMAHSH---GIIHRDLKPQNVLVSSSGTVKVTDFGIAKALSETSLTQ 168 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 +T + G+ Y +PE A T +SD+Y+ G++L ELLTG+ P D Sbjct: 169 TNT-MFGSVHYLSPEQARGSNATVQSDIYAIGIILFELLTGQIPFD 213
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 61.2 bits (147), Expect = 2e-09 Identities = 36/97 (37%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A G+++LH II+RD++ N+LL E+ K+ DF L +A D + +S G Sbjct: 170 ELALGLDHLHSL---GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE T +D +S+GV++ E+LTG P Sbjct: 225 TVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLP 261 Score = 40.4 bits (93), Expect = 0.003 Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 4/99 (4%) Frame = +1 Query: 142 AKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK----AKIADFNLLNQAPDMAARLHSTRV 309 +K +EYLH + ++HRD++ SN+L ++ +I DF Q L + Sbjct: 520 SKTVEYLHSQ---GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTP-- 574 Query: 310 LGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE + D++S GV+L +L G P Sbjct: 575 CYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTP 613
>MP2K2_XENLA (Q07192) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (MAPK-ERK kinase 2) (Fragment) Length = 446 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/105 (39%), Positives = 55/105 (52%), Gaps = 4/105 (3%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 KI + K + +L E ++ IIHRDI+ SN+LL + K+ DF + Q D A+ T Sbjct: 254 KITLATVKALNHLKENLK--IIHRDIKPSNILLDTNGNIKLCDFGISGQLVDSIAK---T 308 Query: 304 RVLGTFGYHAPEYAMTGQLTQ----KSDVYSFGVVLLELLTGRKP 426 R G Y APE Q +SDV+S G+ L EL TGR P Sbjct: 309 RDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFP 353
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 60.8 bits (146), Expect = 2e-09 Identities = 38/106 (35%), Positives = 54/106 (50%), Gaps = 5/106 (4%) Frame = +1 Query: 109 WMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAA 288 W QRV A + A G+ YLH +IIHRD+ S N L+ ED +A+F L P+ Sbjct: 409 WNQRVSFARDIAAGMTYLHSM---NIIHRDLNSHNCLVREDGGLVVANFGLSRLIPEETR 465 Query: 289 RLHSTR-----VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELL 411 L R V+G + APE + DV+SFG+V+ E++ Sbjct: 466 DLRKDRRKRYTVVGNPYWMAPEMINGRSYDESVDVFSFGIVICEII 511
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 60.8 bits (146), Expect = 2e-09 Identities = 34/97 (35%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 +AA G+ +H ++HRDI+ N+L+ + KI DF + A + + V+G Sbjct: 131 QAAHGLSVIHRM---DMVHRDIKPGNMLITANGIVKITDFGIAKAAAAVPLT-RTGMVVG 186 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y +PE A ++T SD+YS GVV E++ GR+P Sbjct: 187 TAQYVSPEQAQGKEVTAASDIYSLGVVGYEMMAGRRP 223
>AVR2B_PIG (Q66T47) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/126 (33%), Positives = 62/126 (49%), Gaps = 13/126 (10%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKV--------QPSIIHRDIRSSNVLLFEDFKAKIA 249 G ++ W + +A ++G+ YLHE V +PSI HRD +S NVLL D A +A Sbjct: 279 GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLA 338 Query: 250 DFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKS-----DVYSFGVVLLELLT 414 DF L + + +GT Y APE Q++ D+Y+ G+VL EL++ Sbjct: 339 DFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRNAFLRIDMYAMGLVLWELVS 398 Query: 415 GRKPVD 432 K D Sbjct: 399 RCKAAD 404
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 60.8 bits (146), Expect = 2e-09 Identities = 36/97 (37%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A +++LH II+RD++ N+LL E+ K+ DF L ++ D + +S G Sbjct: 176 ELALALDHLHSL---GIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYS--FCG 230 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE TQ +D +SFGV++ E+LTG P Sbjct: 231 TVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLP 267 Score = 41.6 bits (96), Expect = 0.001 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDF----KAKIADFNLLNQAPDMAARLHSTRVL 312 K +EYLH + ++HRD++ SN+L ++ +I DF Q L + Sbjct: 525 KTVEYLHAQ---GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY- 580 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE D++S GV+L +LTG P Sbjct: 581 -TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTP 617
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 60.8 bits (146), Expect = 2e-09 Identities = 36/97 (37%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A +++LH II+RD++ N+LL E+ K+ DF L ++ D + +S G Sbjct: 176 ELALALDHLHSL---GIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYS--FCG 230 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE TQ +D +SFGV++ E+LTG P Sbjct: 231 TVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLP 267 Score = 41.6 bits (96), Expect = 0.001 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDF----KAKIADFNLLNQAPDMAARLHSTRVL 312 K +EYLH + ++HRD++ SN+L ++ +I DF Q L + Sbjct: 525 KTVEYLHAQ---GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY- 580 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE D++S GV+L +LTG P Sbjct: 581 -TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTP 617
>SPKA_SYNY3 (Q9FAB3) Serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 521 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/102 (40%), Positives = 55/102 (53%), Gaps = 5/102 (4%) Frame = +1 Query: 139 AAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK----AKIADFNLLNQAPDMAARLHSTR 306 A KGI Y E ++HRDI+ SNVLL ED KI DF + AA T+ Sbjct: 131 AHKGIIYQGEACP--VVHRDIKPSNVLLVEDPALGELVKILDFGIAKLV--QAAEESKTQ 186 Query: 307 V-LGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPV 429 +GT Y +PE +L +SD+YS GV++ E+LTG P+ Sbjct: 187 AFMGTLAYCSPEQMEGKELDSRSDIYSLGVMMYEMLTGEMPL 228
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 60.8 bits (146), Expect = 2e-09 Identities = 31/81 (38%), Positives = 49/81 (60%) Frame = +1 Query: 184 IIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT 363 ++HRD++ N+L+ + KI DF + +A D A + V+GT Y APE A+ T Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIA-KAVDAAPVTQTGMVMGTAQYIAPEQALGHDAT 195 Query: 364 QKSDVYSFGVVLLELLTGRKP 426 SDVYS GV+ E+++G++P Sbjct: 196 PASDVYSLGVIGYEVVSGKRP 216
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/103 (34%), Positives = 52/103 (50%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K + A + YLH+K +IHRDI+ N+LL D + K++DF AP T Sbjct: 191 KYIFQMANALSYLHKK---HVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSN----RRT 243 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 + GT Y PE + T+K D++S GV+ E L G P + Sbjct: 244 TLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFE 286
>AVR2B_MOUSE (P27040) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 536 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 14/127 (11%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKV--------QPSIIHRDIRSSNVLLFEDFKAKIA 249 G ++ W + +A ++G+ YLHE V +PSI HRD +S NVLL D A +A Sbjct: 303 GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLA 362 Query: 250 DFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT------QKSDVYSFGVVLLELL 411 DF L + + +GT Y APE + G + + D+Y+ G+VL EL+ Sbjct: 363 DFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELV 421 Query: 412 TGRKPVD 432 + K D Sbjct: 422 SRCKAAD 428
>AVR2B_RAT (P38445) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 513 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 14/127 (11%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKV--------QPSIIHRDIRSSNVLLFEDFKAKIA 249 G ++ W + +A ++G+ YLHE V +PSI HRD +S NVLL D A +A Sbjct: 280 GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLA 339 Query: 250 DFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT------QKSDVYSFGVVLLELL 411 DF L + + +GT Y APE + G + + D+Y+ G+VL EL+ Sbjct: 340 DFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELV 398 Query: 412 TGRKPVD 432 + K D Sbjct: 399 SRCKAAD 405
>AVR2B_HUMAN (Q13705) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 14/127 (11%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKV--------QPSIIHRDIRSSNVLLFEDFKAKIA 249 G ++ W + +A ++G+ YLHE V +PSI HRD +S NVLL D A +A Sbjct: 279 GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLA 338 Query: 250 DFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT------QKSDVYSFGVVLLELL 411 DF L + + +GT Y APE + G + + D+Y+ G+VL EL+ Sbjct: 339 DFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELV 397 Query: 412 TGRKPVD 432 + K D Sbjct: 398 SRCKAAD 404
>AVR2B_BOVIN (Q95126) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 14/127 (11%) Frame = +1 Query: 94 GPVLDWMQRVKIAIEAAKGIEYLHEKV--------QPSIIHRDIRSSNVLLFEDFKAKIA 249 G ++ W + +A ++G+ YLHE V +PSI HRD +S NVLL D A +A Sbjct: 279 GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLA 338 Query: 250 DFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT------QKSDVYSFGVVLLELL 411 DF L + + +GT Y APE + G + + D+Y+ G+VL EL+ Sbjct: 339 DFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELV 397 Query: 412 TGRKPVD 432 + K D Sbjct: 398 SRCKAAD 404
>KPCT_HUMAN (Q04759) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 706 Score = 60.5 bits (145), Expect = 3e-09 Identities = 35/99 (35%), Positives = 54/99 (54%) Frame = +1 Query: 130 AIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRV 309 A E G+++LH K I++RD++ N+LL +D KIADF + + +M + Sbjct: 485 AAEIILGLQFLHSK---GIVYRDLKLDNILLDKDGHIKIADFGMCKE--NMLGDAKTNTF 539 Query: 310 LGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 GT Y APE + + D +SFGV+L E+L G+ P Sbjct: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSP 578
>FGFR2_DROME (Q09147) Fibroblast growth factor receptor homolog 2 precursor (EC| 2.7.10.1) (Protein breathless) (dFGF-R1) Length = 1052 Score = 60.5 bits (145), Expect = 3e-09 Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 1/107 (0%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 K A + A+G+EYL + IHRD+ + NVL+ + + KIADF L D +T Sbjct: 843 KFAFQIARGMEYLASR---RCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNT 899 Query: 304 RVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKPVDHTM 441 + APE + +SDV+S+GV+L E++T G +P H + Sbjct: 900 NGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHIL 946
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 60.1 bits (144), Expect = 4e-09 Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 6/103 (5%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK-----AKIADFNLLNQAPDMAA 288 +IA+ A G+ YLH + II+RD++ NVLLF + AKIAD+ + M Sbjct: 1973 RIALHVADGLRYLHSAM---IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI 2029 Query: 289 RLHSTRVLGTFGYHAPEYAMTGQL-TQKSDVYSFGVVLLELLT 414 + GT G+ APE A + Q++DVYSFG++L ++LT Sbjct: 2030 KTSE----GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT 2068
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 60.1 bits (144), Expect = 4e-09 Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 1/98 (1%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ-APDMAARLHSTRVL 312 E + +E+LH + +IHRDI+S N+LL D K+ DF Q +P+ R T ++ Sbjct: 397 EVLQALEFLHSR---HVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKR---TTMV 450 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 GT + APE Q K DV+S G++ +E++ G P Sbjct: 451 GTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPP 488
>MP2K3_MOUSE (O09110) Dual specificity mitogen-activated protein kinase kinase 3| (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) Length = 347 Score = 60.1 bits (144), Expect = 4e-09 Identities = 43/142 (30%), Positives = 71/142 (50%), Gaps = 5/142 (3%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 +IA+ + +E+LH K+ S+IHRD++ SNVL+ ++ K+ DF + D A+ T Sbjct: 168 EIAVSIVRALEHLHSKL--SVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAK---T 222 Query: 304 RVLGTFGYHAPEYAMTGQLTQ-----KSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVT 468 G Y APE + +L Q KSDV+S G+ ++E+ R P + + Sbjct: 223 MDAGCKPYMAPE-RINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE-----------S 270 Query: 469 WATPRLSEDKVKQCVDPRLKGE 534 W TP +V + P+L + Sbjct: 271 WGTPFQQLKQVVEEPSPQLPAD 292
>MP2K3_HUMAN (P46734) Dual specificity mitogen-activated protein kinase kinase 3| (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) Length = 347 Score = 60.1 bits (144), Expect = 4e-09 Identities = 43/142 (30%), Positives = 71/142 (50%), Gaps = 5/142 (3%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHST 303 +IA+ + +E+LH K+ S+IHRD++ SNVL+ ++ K+ DF + D A+ T Sbjct: 168 EIAVSIVRALEHLHSKL--SVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAK---T 222 Query: 304 RVLGTFGYHAPEYAMTGQLTQ-----KSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVT 468 G Y APE + +L Q KSDV+S G+ ++E+ R P + + Sbjct: 223 MDAGCKPYMAPE-RINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE-----------S 270 Query: 469 WATPRLSEDKVKQCVDPRLKGE 534 W TP +V + P+L + Sbjct: 271 WGTPFQQLKQVVEEPSPQLPAD 292
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 60.1 bits (144), Expect = 4e-09 Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 2/130 (1%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ-APD 279 +D Q + E + +E+LH +IHRDI+S N+LL D K+ DF Q P+ Sbjct: 361 MDEGQIAAVCRECLQALEFLHSN---QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 417 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQ 456 + R + ++GT + APE K D++S G++ +E++ G P + P R Sbjct: 418 QSKR---STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALY 474 Query: 457 SLVTWATPRL 486 + T TP L Sbjct: 475 LIATNGTPEL 484
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 60.1 bits (144), Expect = 4e-09 Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 2/130 (1%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ-APD 279 +D Q + E + +E+LH +IHRDI+S N+LL D K+ DF Q P+ Sbjct: 361 MDEGQIAAVCRECLQALEFLHSN---QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 417 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQ 456 + R + ++GT + APE K D++S G++ +E++ G P + P R Sbjct: 418 QSKR---STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALY 474 Query: 457 SLVTWATPRL 486 + T TP L Sbjct: 475 LIATNGTPEL 484
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 60.1 bits (144), Expect = 4e-09 Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 2/130 (1%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ-APD 279 +D Q + E + +E+LH +IHRDI+S N+LL D K+ DF Q P+ Sbjct: 360 MDEGQIAAVCRECLQALEFLHSN---QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 416 Query: 280 MAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP-RGQQ 456 + R + ++GT + APE K D++S G++ +E++ G P + P R Sbjct: 417 QSKR---STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALY 473 Query: 457 SLVTWATPRL 486 + T TP L Sbjct: 474 LIATNGTPEL 483
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.1 bits (144), Expect = 4e-09 Identities = 43/120 (35%), Positives = 60/120 (50%), Gaps = 12/120 (10%) Frame = +1 Query: 109 WMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLL-------N 267 W QRV A + A G+ YLH +IIHRD+ S N L+ E+ +ADF L Sbjct: 434 WSQRVSFAKDIASGMAYLHSM---NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKG 490 Query: 268 QAPDMAA-----RLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 Q+ D+ + R V+G + APE +K DV+SFG+VL E++ GR D Sbjct: 491 QSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.1 bits (144), Expect = 4e-09 Identities = 42/120 (35%), Positives = 57/120 (47%), Gaps = 12/120 (10%) Frame = +1 Query: 109 WMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAA 288 W QRV A + A G+ YLH +IIHRD+ S N L+ E+ +ADF L D Sbjct: 434 WSQRVSFAKDIASGMAYLHSM---NIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKT 490 Query: 289 RLHSTR------------VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVD 432 + R V+G + APE +K DV+SFG+VL E++ GR D Sbjct: 491 QPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 60.1 bits (144), Expect = 4e-09 Identities = 39/122 (31%), Positives = 62/122 (50%), Gaps = 11/122 (9%) Frame = +1 Query: 94 GP-VLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 GP +L + Q K+ ++ G+EYLH + I HRDI+ SN+L+ + KI+DF + Sbjct: 157 GPSILTFQQSRKVVLDVVSGLEYLHSQ---GITHRDIKPSNLLISSNGTVKISDFGVAMS 213 Query: 271 APDMAARLHS-------TRVLGTFGYHAPEYAMTGQ---LTQKSDVYSFGVVLLELLTGR 420 + + S +R LGT + APE T + + D++S GV + LL G+ Sbjct: 214 TATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGK 273 Query: 421 KP 426 P Sbjct: 274 LP 275
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 60.1 bits (144), Expect = 4e-09 Identities = 47/141 (33%), Positives = 61/141 (43%), Gaps = 23/141 (16%) Frame = +1 Query: 85 AQPGPVLDWMQRVKIAIEA---------AKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK 237 AQ G VL+W+QR E A GI YLH K I+HRD++ N+LL + Sbjct: 105 AQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSK---GIVHRDLKLENLLLDKREN 161 Query: 238 AKIADFNLLNQAP------------DMAARLH-STRVLGTFGYHAPEYAMTGQLTQ-KSD 375 KI+DF P M + H S G+F Y PE + SD Sbjct: 162 VKISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAYACPEILLGLPYNPFLSD 221 Query: 376 VYSFGVVLLELLTGRKPVDHT 438 +S GV+L L+ R P D T Sbjct: 222 TWSMGVILYTLVVARLPFDDT 242
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 60.1 bits (144), Expect = 4e-09 Identities = 35/104 (33%), Positives = 55/104 (52%) Frame = +1 Query: 115 QRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARL 294 Q I E +G+++LH K IIHRDI+S N+LL KI DF + + ++ Sbjct: 483 QMAYIVKETCQGLKFLHNK---KIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSK- 538 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 ++GT + APE +K DV+S G++L+E++ G P Sbjct: 539 -RATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPP 581
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 59.7 bits (143), Expect = 5e-09 Identities = 35/97 (36%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A G+++LH II+RD++ N+LL E+ K+ DF L +A D + +S G Sbjct: 170 ELALGLDHLHSL---GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE + +D +S+GV++ E+LTG P Sbjct: 225 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLP 261 Score = 37.0 bits (84), Expect = 0.035 Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 4/104 (3%) Frame = +1 Query: 127 IAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDF----KAKIADFNLLNQAPDMAARL 294 + K +E LH + ++HRD++ SN+L ++ +I DF Q L Sbjct: 513 VLFTVCKTVENLHSQ---GVVHRDLKPSNILYVDESGDPESIRICDFGFAKQLRADNGLL 569 Query: 295 HSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 + T + APE + D++S G++L +L G P Sbjct: 570 MTP--CYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 611
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (CD333 antigen) Length = 806 Score = 59.7 bits (143), Expect = 5e-09 Identities = 39/108 (36%), Positives = 55/108 (50%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P L + V A + A+G+EYL + IHRD+ + NVL+ ED KIADF L Sbjct: 585 PEEQLTFKDLVSCAYQVARGMEYLASQ---KCIHRDLAARNVLVTEDNVMKIADFGLARD 641 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 ++ +T + APE T +SDV+SFGV+L E+ T Sbjct: 642 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 689
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 59.7 bits (143), Expect = 5e-09 Identities = 39/119 (32%), Positives = 63/119 (52%), Gaps = 13/119 (10%) Frame = +1 Query: 124 KIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLL---------NQAP 276 +I +E +G+ YLH K +IH+D++ N+L+ DF KIAD L N+ Sbjct: 117 RIILEIIEGMCYLHGK---GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 173 Query: 277 DMAARLHST--RVLGTFGYHAPEYA--MTGQLTQKSDVYSFGVVLLELLTGRKPVDHTM 441 + + T + GT Y APE+ + + T+KSDVYSF VVL + ++P ++ + Sbjct: 174 NELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAI 232
>PKN1_CORGL (Q8NU98) Probable serine/threonine protein kinase pknB (EC| 2.7.11.1) Length = 646 Score = 59.7 bits (143), Expect = 5e-09 Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 5/109 (4%) Frame = +1 Query: 133 IEAAKGIEYLHEKVQPS----IIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHS 300 +EAA + + E +Q S IIHRD++ +N+++ K+ DF + D + + Sbjct: 111 VEAANILIPVCEALQASHDAGIIHRDVKPANIMITNTGGVKVMDFGIARAVNDSTSAMTQ 170 Query: 301 TR-VLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMP 444 T V+GT Y +PE A +SD+Y+ G V+ EL+TG+ P + P Sbjct: 171 TSAVIGTAQYLSPEQARGKPADARSDIYATGCVMYELVTGKPPFEGESP 219
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 59.7 bits (143), Expect = 5e-09 Identities = 40/108 (37%), Positives = 54/108 (50%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P L + V A + A+G+EYL K IHRD+ + NVL+ ED KIADF L Sbjct: 589 PEEQLSFKDLVSCAYQVARGMEYLASK---KCIHRDLAARNVLVTEDNVMKIADFGLARD 645 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 + +T + APE T +SDV+SFGV+L E+ T Sbjct: 646 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 693
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) Length = 812 Score = 59.7 bits (143), Expect = 5e-09 Identities = 39/108 (36%), Positives = 55/108 (50%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P +L + V A + A+G++YL K IHRD+ + NVL+ ED KIADF L Sbjct: 585 PDQLLSFKDLVSCAYQVARGMDYLASK---KCIHRDLAARNVLVTEDNIMKIADFGLARD 641 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 + +T + APE T +SDV+SFGV+L E+ T Sbjct: 642 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 689
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 59.7 bits (143), Expect = 5e-09 Identities = 42/141 (29%), Positives = 68/141 (48%), Gaps = 1/141 (0%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P V+ +K A + A+G++YL + IHRD+ + NVL+ +D+ KIADF L Sbjct: 524 PAHVITEKDLIKFAHQIARGMDYLASR---RCIHRDLAARNVLVSDDYVLKIADFGLARD 580 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKPVDHTMPR 447 +T + APE KSDV+S+G++L E++T G++P M Sbjct: 581 IQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM-- 638 Query: 448 GQQSLVTWATPRLSEDKVKQC 510 + L T+ +K +C Sbjct: 639 SAEELYTYLMSGQRMEKPAKC 659
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 59.7 bits (143), Expect = 5e-09 Identities = 35/97 (36%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A G+++LH II+RD++ N+LL E+ K+ DF L +A D + +S G Sbjct: 188 ELALGLDHLHSL---GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 242 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE + +D +S+GV++ E+LTG P Sbjct: 243 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLP 279 Score = 40.4 bits (93), Expect = 0.003 Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDF----KAKIADFNLLNQAPDMAARLHSTRVL 312 K +EYLH + ++HRD++ SN+L ++ +I DF Q L + Sbjct: 538 KTVEYLHSQ---GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP--C 592 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE + D++S GV+L +L G P Sbjct: 593 YTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCTP 630
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 59.7 bits (143), Expect = 5e-09 Identities = 36/126 (28%), Positives = 62/126 (49%), Gaps = 4/126 (3%) Frame = +1 Query: 61 MXRKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKA 240 M ++ P L W +++I E + + +LH ++P ++H D++ N+LL + Sbjct: 113 MASGSLEKTLPTHSLCWPLKLRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLDNNMHV 171 Query: 241 KIADFNLLNQAPDMAARLHSTR--VLGTFGYHAPEYAMTGQLT--QKSDVYSFGVVLLEL 408 KI+DF L + + R + GT Y PE + + DVYSF +V+ E+ Sbjct: 172 KISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEI 231 Query: 409 LTGRKP 426 LT +KP Sbjct: 232 LTQKKP 237
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 59.7 bits (143), Expect = 5e-09 Identities = 35/97 (36%), Positives = 54/97 (55%) Frame = +1 Query: 136 EAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLG 315 E A G+++LH II+RD++ N+LL E+ K+ DF L +A D + +S G Sbjct: 170 ELALGLDHLHSL---GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 316 TFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T Y APE + +D +S+GV++ E+LTG P Sbjct: 225 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLP 261 Score = 39.7 bits (91), Expect = 0.005 Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDFK----AKIADFNLLNQAPDMAARLHSTRVL 312 K +EYLH + ++HRD++ SN+L ++ +I DF Q L + Sbjct: 521 KTVEYLHSQ---GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTP--C 575 Query: 313 GTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 T + APE + D++S G++L +L G P Sbjct: 576 YTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 613
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 59.3 bits (142), Expect = 7e-09 Identities = 37/113 (32%), Positives = 59/113 (52%), Gaps = 5/113 (4%) Frame = +1 Query: 103 LDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNL---LNQA 273 L W R +I E + + +LH ++P ++H D++ N+LL + KI+DF L + Q+ Sbjct: 115 LCWKLRFRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQS 173 Query: 274 PDMAARLHSTRVLGTFGYHAPEYAMTGQLT--QKSDVYSFGVVLLELLTGRKP 426 M + + + G Y PE + K DVYSF +V+ ELLT +KP Sbjct: 174 TRM-QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKP 225
>KPCT_MOUSE (Q02111) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 707 Score = 59.3 bits (142), Expect = 7e-09 Identities = 34/99 (34%), Positives = 53/99 (53%) Frame = +1 Query: 130 AIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRV 309 A E G+++LH K I++RD++ N+LL D KIADF + + +M + Sbjct: 485 AAEVILGLQFLHSK---GIVYRDLKLDNILLDRDGHIKIADFGMCKE--NMLGDAKTNTF 539 Query: 310 LGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKP 426 GT Y APE + + D +SFGV++ E+L G+ P Sbjct: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSP 578
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 59.3 bits (142), Expect = 7e-09 Identities = 39/108 (36%), Positives = 55/108 (50%) Frame = +1 Query: 91 PGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQ 270 P L + V A + A+G+EYL + IHRD+ + NVL+ ED KIADF L Sbjct: 579 PEEQLTFKDLVSCAYQVARGMEYLASQ---KCIHRDLAARNVLVTEDNVMKIADFGLARD 635 Query: 271 APDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT 414 ++ +T + APE T +SDV+SFGV+L E+ T Sbjct: 636 VHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 683
>RIPK5_CHICK (Q6XUX0) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 58.9 bits (141), Expect = 9e-09 Identities = 43/136 (31%), Positives = 67/136 (49%) Frame = +1 Query: 40 VLFTMFCMXRKGVQGAQPGPVLDWMQRVKIAIEAAKGIEYLHEKVQPSIIHRDIRSSNVL 219 VL M + R G + G L+ R++IA++ +GI YLH + ++HRDI+ NVL Sbjct: 731 VLLIMERLHRDLYTGLKAG--LELETRLQIALDVVEGIRYLHSQ---GLVHRDIKLKNVL 785 Query: 220 LFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVL 399 L + +AKI D M S ++GT + APE TG+ DVY+FG++ Sbjct: 786 LDKKNRAKITDLGFCKPEAMM-----SGSIVGTPIHMAPE-LFTGKYDNSVDVYAFGILF 839 Query: 400 LELLTGRKPVDHTMPR 447 + +G + R Sbjct: 840 WYICSGHVKLPEAFER 855
>PKNA_MYCTU (P65726) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 58.9 bits (141), Expect = 9e-09 Identities = 31/81 (38%), Positives = 48/81 (59%) Frame = +1 Query: 184 IIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT 363 ++HRD++ N+L+ + KI DF + +A D A + V+GT Y APE A+ + Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIA-KAVDAAPVTQTGMVMGTAQYIAPEQALGHDAS 195 Query: 364 QKSDVYSFGVVLLELLTGRKP 426 SDVYS GVV E ++G++P Sbjct: 196 PASDVYSLGVVGYEAVSGKRP 216
>PKNA_MYCBO (P65727) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 58.9 bits (141), Expect = 9e-09 Identities = 31/81 (38%), Positives = 48/81 (59%) Frame = +1 Query: 184 IIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLT 363 ++HRD++ N+L+ + KI DF + +A D A + V+GT Y APE A+ + Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIA-KAVDAAPVTQTGMVMGTAQYIAPEQALGHDAS 195 Query: 364 QKSDVYSFGVVLLELLTGRKP 426 SDVYS GVV E ++G++P Sbjct: 196 PASDVYSLGVVGYEAVSGKRP 216
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 58.9 bits (141), Expect = 9e-09 Identities = 42/133 (31%), Positives = 67/133 (50%), Gaps = 10/133 (7%) Frame = +1 Query: 145 KGIEYLHEKVQPSIIHRDIRSSNVLLFEDFKAKIADFNLLNQAPDMAARLHSTRVLGTFG 324 KG+EYLH + IHRDI++ N+LL + AK+ADF + Q D A+ ++ V+GT Sbjct: 132 KGLEYLHFMRK---IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT--VIGTPF 186 Query: 325 YHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLV------TWATPRL 486 + APE +D++S G+ +E+ G+ P P ++ T+ P L Sbjct: 187 WMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 246 Query: 487 SEDK----VKQCV 513 D VK+C+ Sbjct: 247 WSDDFTDFVKKCL 259 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 79,791,418 Number of Sequences: 219361 Number of extensions: 1617124 Number of successful extensions: 6848 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5441 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5671 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4258037034 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
