ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags8b01 |
|---|---|
| Clone Library Name | barley_pub |
>AK1A1_RAT (P51635) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde| reductase) (Aldo-keto reductase family 1 member A1) (3-DG-reducing enzyme) Length = 324 Score = 128 bits (321), Expect = 1e-29 Identities = 63/153 (41%), Positives = 99/153 (64%), Gaps = 9/153 (5%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP+ ++G N P+N + + TW A+E L G +A+G+SNFSS+++ D Sbjct: 111 MHWPYAFERGDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDD 170 Query: 258 LLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN---VLKE 428 +L+VA V PAV QVECHP Q +L CQ+ G+ ++AYSPLGS W + + +L+E Sbjct: 171 VLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEE 230 Query: 429 PIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 P++++++EK G++PAQ+ LRW +Q +PKS Sbjct: 231 PVVLALAEKHGRSPAQILLRWQVQRKVICIPKS 263
>AK1A1_HUMAN (P14550) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde| reductase) (Aldo-keto reductase family 1 member A1) Length = 324 Score = 127 bits (320), Expect = 1e-29 Identities = 62/153 (40%), Positives = 99/153 (64%), Gaps = 9/153 (5%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP+ ++G N P+N + + TW A+E L G +A+G+SNF+S+++ D Sbjct: 111 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDD 170 Query: 258 LLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN---VLKE 428 +L+VA V PAV QVECHP Q +L CQ+ G+ ++AYSPLGS W + + +L+E Sbjct: 171 ILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEE 230 Query: 429 PIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 P++++++EK G++PAQ+ LRW +Q +PKS Sbjct: 231 PVVLALAEKYGRSPAQILLRWQVQRKVICIPKS 263
>AK1A1_PIG (P50578) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde| reductase) (Aldo-keto reductase family 1 member A1) Length = 324 Score = 127 bits (318), Expect = 3e-29 Identities = 64/153 (41%), Positives = 96/153 (62%), Gaps = 9/153 (5%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP+ ++G N P+N + TW A+E L G RA+G+SNFSS+++ D Sbjct: 111 MHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDD 170 Query: 258 LLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN---VLKE 428 +L+VA V PAV QVECHP Q +L CQ+ G+ ++AYSPLGS W + N +L+E Sbjct: 171 VLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEE 230 Query: 429 PIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 P++ +++EK ++PAQ+ LRW +Q +PKS Sbjct: 231 PVVQALAEKYNRSPAQILLRWQVQRKVICIPKS 263
>AK1A1_MOUSE (Q9JII6) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde| reductase) (Aldo-keto reductase family 1 member A1) Length = 324 Score = 126 bits (317), Expect = 3e-29 Identities = 62/155 (40%), Positives = 99/155 (63%), Gaps = 9/155 (5%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP+ ++G N P+N + + TW A+E L G +A+G+SNF+S+++ D Sbjct: 111 MHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDD 170 Query: 258 LLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN---VLKE 428 +L+VA V PAV QVECHP Q +L C + G+ ++AYSPLGS W + + +L+E Sbjct: 171 VLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEE 230 Query: 429 PIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 P++++++EK G++PAQ+ LRW +Q +PKS N Sbjct: 231 PVVLALAEKHGRSPAQILLRWQVQRKVICIPKSIN 265
>ALDR_HORVU (P23901) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| Length = 320 Score = 125 bits (315), Expect = 6e-29 Identities = 62/147 (42%), Positives = 89/147 (60%), Gaps = 2/147 (1%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPE--NFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAV 269 IHWPFR+K G + PE + D+ W ME L G + IGV N++ KL LL Sbjct: 120 IHWPFRLKDGAHMPPEAGEVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRS 179 Query: 270 ARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISIS 449 A++PPAV Q+E HP W+ K+ C+ G+H++AYSPLGS N+ +P++ ++ Sbjct: 180 AKIPPAVCQMEMHPGWKNDKIFEACKKHGIHVTAYSPLGS-----SEKNLAHDPVVEKVA 234 Query: 450 EKLGKTPAQVALRWNIQTGHSVLPKST 530 KL KTP QV ++W +Q G SV+PKS+ Sbjct: 235 NKLNKTPGQVLIKWALQRGTSVIPKSS 261
>NADO1_ORYSA (Q7G764) Probable NAD(P)H-dependent oxidoreductase 1 (EC 1.1.1.-)| Length = 321 Score = 125 bits (314), Expect = 7e-29 Identities = 66/150 (44%), Positives = 89/150 (59%), Gaps = 4/150 (2%) Frame = +3 Query: 96 IHWPFRVKKGTNNNP--ENFVTP--DIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLL 263 +HWP + G + P + + P D+ W ME+ H G ARAIGVSNFS+KKL LL Sbjct: 117 VHWPVSLTPGNYDFPFPKEVILPSFDMEGVWRGMEECHRLGLARAIGVSNFSAKKLEQLL 176 Query: 264 AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIIS 443 ++A V PAV+QVE +P WQQ L C+ GV L YSPLG+ GT W + V+ ++ Sbjct: 177 SLAAVRPAVNQVEVNPMWQQRTLREVCRREGVQLCGYSPLGAKGTPWGSAAVMDSGVLQE 236 Query: 444 ISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 I+ GKT AQ+ LRW + G +L K+ N Sbjct: 237 IAGAKGKTLAQICLRWLYEQGDVLLVKTYN 266
>NADO2_ORYSA (Q7G765) Probable NAD(P)H-dependent oxidoreductase 2 (EC 1.-.-.-)| Length = 322 Score = 124 bits (311), Expect = 2e-28 Identities = 66/150 (44%), Positives = 87/150 (58%), Gaps = 4/150 (2%) Frame = +3 Query: 96 IHWPFRVKKGTNNNP----ENFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLL 263 +HWP V G+ + P E D+ W ME+ H G ARAIGVSNFS+KKL LL Sbjct: 119 VHWPATVAPGSYDFPFPKEEMAPAFDMEGVWRGMEECHRLGLARAIGVSNFSAKKLEQLL 178 Query: 264 AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIIS 443 + A V PA +QVE +P WQQ L C+ GV L YSPLG+ GT W + V+ ++ Sbjct: 179 SFAVVRPAANQVEMNPMWQQRTLREVCRREGVQLCGYSPLGAKGTPWGSAAVMDSGVLHD 238 Query: 444 ISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 I++ GKT AQ+ LRW + G +L K+ N Sbjct: 239 IAQTKGKTLAQICLRWMYEQGDVLLVKTYN 268
>6DCS_SOYBN (P26690) NAD(P)H dependent 6'-deoxychalcone synthase (EC 2.3.1.170)| Length = 315 Score = 113 bits (282), Expect = 4e-25 Identities = 64/165 (38%), Positives = 93/165 (56%), Gaps = 3/165 (1%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNP---ENFVTPDIPATWGAMEKLHDAGKA 212 AL +S IHWP + G + P E+ + D+ W +ME+ G Sbjct: 102 ALRKSLKTLQLEYLDLYLIHWPLSSQPGKFSFPIEVEDLLPFDVKGVWESMEECQKLGLT 161 Query: 213 RAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSP 392 +AIGVSNFS KKL +LL+VA + P VDQVE + WQQ KL FC+ G+ ++A+SPL Sbjct: 162 KAIGVSNFSVKKLQNLLSVATIRPVVDQVEMNLAWQQKKLREFCKENGIIVTAFSPLRKG 221 Query: 393 GTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + N V++ ++ I+E GK+ AQV+LRW + G + +PKS Sbjct: 222 ASRGPN-EVMENDVLKEIAEAHGKSIAQVSLRWLYEQGVTFVPKS 265
>GCY_YEAST (P14065) GCY protein (EC 1.1.1.-)| Length = 312 Score = 112 bits (279), Expect = 8e-25 Identities = 66/182 (36%), Positives = 94/182 (51%), Gaps = 16/182 (8%) Frame = +3 Query: 36 QXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTP--------------DIPAT 173 + AL++S +HWP R+ N + P + T Sbjct: 91 EVALDQSLKRLGLDYVDLYLMHWPARLDPAYIKNEDILSVPTKKDGSRAVDITNWNFIKT 150 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAVDQVECHPCWQQTKLHNFCQ 347 W M++L GK +A+GVSNFS L DLLA ++ PA +QVE HP Q +L NFC+ Sbjct: 151 WELMQELPKTGKTKAVGVSNFSINNLKDLLASQGNKLTPAANQVEIHPLLPQDELINFCK 210 Query: 348 SAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 S G+ + AYSPLGS + +LKEP+I+ I++K P V + W++Q G+ VLPKS Sbjct: 211 SKGIVVEAYSPLGS-----TDAPLLKEPVILEIAKKNNVQPGHVVISWHVQRGYVVLPKS 265 Query: 528 TN 533 N Sbjct: 266 VN 267
>ALDR_BOVIN (P16116) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) Length = 315 Score = 110 bits (275), Expect = 2e-24 Identities = 66/155 (42%), Positives = 92/155 (59%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNP---ENFVTP---DIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P + V P D TW AME+L D G +AIGVSNF+ ++ Sbjct: 109 IHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEK 168 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + PAV+Q+ECHP Q KL +C S G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSIL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I +I++K KT AQV +R+ IQ V+PKS Sbjct: 229 EDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKS 263
>AK1C1_PONPY (Q5REQ0) Aldo-keto reductase family 1 member C1 homolog (EC| 1.-.-.-) (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) Length = 323 Score = 110 bits (275), Expect = 2e-24 Identities = 66/158 (41%), Positives = 98/158 (62%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +H+P VK G P++ F T D+ ATW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 VHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP + Q KL +FC+S + L AYS LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEKWVDPNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYN 273
>AK1C2_HUMAN (P52895) Aldo-keto reductase family 1 member C2 (EC 1.-.-.-)| (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.213) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) ( Length = 323 Score = 110 bits (274), Expect = 3e-24 Identities = 67/158 (42%), Positives = 97/158 (61%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P VK G P++ F T D+ ATW AMEK DAG A++IGVSNF+ + L Sbjct: 116 IHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEM 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP + Q KL +FC+S + L AYS LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>AK1C1_HUMAN (Q04828) Aldo-keto reductase family 1 member C1 (EC 1.1.1.-)| (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (High-affinity hepatic bile acid-binding protei Length = 323 Score = 109 bits (273), Expect = 4e-24 Identities = 66/158 (41%), Positives = 98/158 (62%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P VK G P++ F T D+ ATW A+EK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP + Q KL +FC+S + L AYS LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>AK1C1_MACFU (Q95JH6) Aldo-keto reductase family 1 member C1 homolog (EC| 1.-.-.-) (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) (Dihydrodiol dehydrogenase 1) (DD-1) (DD1) Length = 323 Score = 108 bits (271), Expect = 7e-24 Identities = 66/158 (41%), Positives = 97/158 (61%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G P++ F T D+ ATW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPVSLKPGEELIPKDENGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP Q KL +FC+S + L AYS LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYLNQRKLLDFCKSKDIVLVAYSALGSHREKPWVDQNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>AK1C4_HUMAN (P17516) Aldo-keto reductase family 1 member C4 (EC 1.1.1.-)| (Chlordecone reductase) (EC 1.1.1.225) (CDR) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (3-alpha-HSD1) (Dihydrodiol dehydrogenase 4) (DD4) (HAKRA) Length = 323 Score = 108 bits (270), Expect = 9e-24 Identities = 67/180 (37%), Positives = 102/180 (56%), Gaps = 12/180 (6%) Frame = +3 Query: 30 MCQXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEK 191 M Q AL S +H+P +K G P++ F T D+ ATW MEK Sbjct: 94 MVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEK 153 Query: 192 LHDAGKARAIGVSNFSSKKLGDLL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHL 365 DAG A++IGVSNF+ ++L +L + P +QVECHP Q+KL +FC+S + L Sbjct: 154 CKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVL 213 Query: 366 SAYSPLGSP-GTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 A+S LG+ W++ N +L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 214 VAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>XYL1_CANTE (O74237) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 322 Score = 108 bits (270), Expect = 9e-24 Identities = 67/137 (48%), Positives = 80/137 (58%), Gaps = 9/137 (6%) Frame = +3 Query: 144 NFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCW 317 NFV D+P TW A+EKL AGK ++IGVSNF L DLL A + PAV QVE HP Sbjct: 139 NFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDLLRGATIKPAVLQVEHHPYL 198 Query: 318 QQTKLHNFCQSAGVHLSAYSPLGSPGTTWMN-GNVLKEPIII------SISEKLGKTPAQ 476 QQ KL F Q AGV ++AYS G MN G L P + +I+ K KTPA+ Sbjct: 199 QQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTLFAHDTIKAIAAKYNKTPAE 258 Query: 477 VALRWNIQTGHSVLPKS 527 V LRW Q G +V+PKS Sbjct: 259 VLLRWAAQRGIAVIPKS 275
>ALDR_HUMAN (P15121) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| Length = 315 Score = 107 bits (267), Expect = 2e-23 Identities = 66/155 (42%), Positives = 91/155 (58%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNP----ENFVTPD--IPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G P N V D I TW AME+L D G +AIG+SNF+ ++ Sbjct: 109 IHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEM 168 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + PAV+Q+ECHP Q KL +CQS G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I +I+ K KT AQV +R+ +Q V+PKS Sbjct: 229 EDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKS 263
>DDBX_BOVIN (P52898) Dihydrodiol dehydrogenase 3 (EC 1.-.-.-) (Prostaglandin F| synthase) Length = 323 Score = 107 bits (267), Expect = 2e-23 Identities = 66/158 (41%), Positives = 95/158 (60%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G P + F + D+ TW A+EK DAG ++IGVSNF+ K+L Sbjct: 116 IHFPVALKPGETLFPTDENGKPIFDSVDLCRTWEALEKCKDAGLTKSIGVSNFNHKQLEK 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPG-TTWMNGN---V 419 +L + P +QVECHP + Q+KL +FC+S + L AY LGS W+N N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYFNQSKLLDFCKSHDIVLVAYGALGSQRLKEWVNPNLPFL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ +I++K +TPA VALR+ IQ G VL KS N Sbjct: 236 LEDPVLSAIAKKHRQTPALVALRYQIQRGVVVLAKSYN 273
>AK1C1_MACFA (Q95JH7) Aldo-keto reductase family 1 member C1 homolog (EC| 1.-.-.-) (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) (Dihydrodiol dehydrogenase 1) (DD-1) (DD1) Length = 323 Score = 107 bits (267), Expect = 2e-23 Identities = 65/158 (41%), Positives = 97/158 (61%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G P++ F T D+ ATW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPVSLKPGEELIPKDENGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP Q KL +FC+S + L A+S LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYLNQRKLLDFCKSKDIVLVAFSALGSHREKPWVDQNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>ALDR_MOUSE (P45376) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| Length = 315 Score = 107 bits (266), Expect = 3e-23 Identities = 64/155 (41%), Positives = 90/155 (58%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPA------TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P + IP+ TW AME+L D G + IGVSNF+ ++ Sbjct: 109 IHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIER 168 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + PAV+Q+ECHP Q KL +C S G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I +I+ K KT AQV +R+ IQ V+PKS Sbjct: 229 EDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKS 263
>PE2R_RABIT (P80508) Prostaglandin-E(2) 9-reductase (EC 1.1.1.189)| (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) Length = 323 Score = 106 bits (264), Expect = 5e-23 Identities = 67/156 (42%), Positives = 95/156 (60%), Gaps = 12/156 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G P + F T DI ATW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPTALKPGVEIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP Q KL FC+S G+ L AYS LGS W++ + + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 L++P+I ++++K +TPA +ALR+ +Q G VL KS Sbjct: 236 LEDPLIGALAKKHQQTPALIALRYQLQRGIVVLAKS 271
>ALDR_RAT (P07943) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| Length = 315 Score = 106 bits (264), Expect = 5e-23 Identities = 64/155 (41%), Positives = 89/155 (57%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPA------TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P + IP+ TW AME+L D G +AIGVSNF+ ++ Sbjct: 109 IHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIER 168 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + PAV+Q+ECHP Q KL +C G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I I+ K KT AQV +R+ IQ V+PKS Sbjct: 229 EDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKS 263
>AK1C3_HUMAN (P42330) Aldo-keto reductase family 1 member C3 (EC 1.-.-.-)| (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (3-alpha-hydroxysteroid dehydrogenase type 2) (EC 1.1.1.213) (3-alpha-HSD type 2) (3-alpha-HSD type II, brain) (Prost Length = 323 Score = 105 bits (263), Expect = 6e-23 Identities = 63/158 (39%), Positives = 96/158 (60%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH P +K G +P + F D+ TW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSP-GTTWMNGN---V 419 +L + P +QVECHP + ++KL +FC+S + L AYS LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>ALDR_RABIT (P15122) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| Length = 315 Score = 105 bits (263), Expect = 6e-23 Identities = 63/155 (40%), Positives = 91/155 (58%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPA------TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G+ P + IP+ TW AME L D G ++IGVSNF+ ++ Sbjct: 109 IHWPTGFKHGSEYFPLDAAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIER 168 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + PAV+Q+ECHP Q KL +C S G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKYKPAVNQIECHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I +I++K KT AQV +R+ +Q V+PKS Sbjct: 229 EDPRIKAIADKHKKTTAQVLIRFPMQRNLVVIPKS 263
>AK1A1_CRIGR (O70473) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde| reductase) (Aldo-keto reductase family 1 member A1) (Fragment) Length = 228 Score = 105 bits (263), Expect = 6e-23 Identities = 52/132 (39%), Positives = 85/132 (64%), Gaps = 9/132 (6%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP+ ++G N P+N + + TW A+E L G +A+G+SNF+S+++ D Sbjct: 97 MHWPYAFERGDNPFPKNDDGTIRYDSTHYKETWKALEALVAKGLVKALGLSNFNSRQIDD 156 Query: 258 LLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN---VLKE 428 +L+VA V PAV QVECHP Q +L CQ+ G+ ++AYSPLGS W + + +L+E Sbjct: 157 ILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEE 216 Query: 429 PIIISISEKLGK 464 P++++++EK G+ Sbjct: 217 PVVLALAEKHGR 228
>XYL1_CANSH (Q9P430) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 323 Score = 105 bits (262), Expect = 8e-23 Identities = 64/138 (46%), Positives = 80/138 (57%), Gaps = 9/138 (6%) Frame = +3 Query: 141 ENFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPC 314 +NFV D+P TW A+EKL AGK R+IGVSNF L DL A + PAV QVE HP Sbjct: 139 DNFVYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLFRGATIKPAVLQVEHHPY 198 Query: 315 WQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMN-GNVLKEP------IIISISEKLGKTPA 473 QQ KL + Q G+ ++AYS G MN G L P +I +I+ K K PA Sbjct: 199 LQQPKLIEYAQKVGITVTAYSSFGPQSFVEMNQGRALNTPTLFEHDVIKAIAAKHNKVPA 258 Query: 474 QVALRWNIQTGHSVLPKS 527 +V LRW+ Q G +V+PKS Sbjct: 259 EVLLRWSAQRGIAVIPKS 276
>PGFS2_BOVIN (P52897) Prostaglandin-F synthase 2 (EC 1.1.1.188) (PGF synthase 2)| (PGF 2) (Prostaglandin-D2 11 reductase 2) (PGFSII) Length = 323 Score = 105 bits (262), Expect = 8e-23 Identities = 68/186 (36%), Positives = 103/186 (55%), Gaps = 12/186 (6%) Frame = +3 Query: 12 SSCSXXMCQXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPEN------FVTPDIPAT 173 +S + + AL +S IH P +K G P++ F + D+ T Sbjct: 88 NSLQPELVRPALEKSLQNLQLDYVDLYIIHSPVSLKPGNKFVPKDESGKLIFDSVDLCHT 147 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAVDQVECHPCWQQTKLHNFCQ 347 W A+EK DAG ++IGVSNF+ K+L +L + P +QVECHP Q+KL FC+ Sbjct: 148 WEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCK 207 Query: 348 SAGVHLSAYSPLGSP-GTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGHSV 515 S + L AY+ LG+ + W+N N +L++P++ +I++K +TPA VALR+ +Q G V Sbjct: 208 SHDIVLVAYAALGAQLLSEWVNSNNPVLLEDPVLCAIAKKHKQTPALVALRYQVQRGVVV 267 Query: 516 LPKSTN 533 L KS N Sbjct: 268 LAKSFN 273
>PGFS1_BOVIN (P05980) Prostaglandin-F synthase 1 (EC 1.1.1.188) (PGF synthase 1)| (PGF 1) (Prostaglandin-D2 11 reductase 1) (PGFSI) Length = 323 Score = 105 bits (262), Expect = 8e-23 Identities = 68/186 (36%), Positives = 103/186 (55%), Gaps = 12/186 (6%) Frame = +3 Query: 12 SSCSXXMCQXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPEN------FVTPDIPAT 173 +S + + AL +S IH P +K G P++ F + D+ T Sbjct: 88 NSLQPELVRPALEKSLQNLQLDYVDLYIIHSPVSLKPGNKFVPKDESGKLIFDSVDLCHT 147 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAVDQVECHPCWQQTKLHNFCQ 347 W A+EK DAG ++IGVSNF+ K+L +L + P +QVECHP Q+KL FC+ Sbjct: 148 WEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCK 207 Query: 348 SAGVHLSAYSPLGSP-GTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGHSV 515 S + L AY+ LG+ + W+N N +L++P++ +I++K +TPA VALR+ +Q G V Sbjct: 208 SHDIVLVAYAALGAQLLSEWVNSNNPVLLEDPVLCAIAKKHKQTPALVALRYQVQRGVVV 267 Query: 516 LPKSTN 533 L KS N Sbjct: 268 LAKSFN 273
>AK1C4_MACFU (Q95JH4) Aldo-keto reductase family 1 member C4 (EC 1.1.1.-)| (Chlordecone reductase) (EC 1.1.1.225) (CDR) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (3-alpha-HSD1) (Dihydrodiol dehydrogenase 4) (DD4) (DD-4) Length = 323 Score = 105 bits (261), Expect = 1e-22 Identities = 66/180 (36%), Positives = 102/180 (56%), Gaps = 12/180 (6%) Frame = +3 Query: 30 MCQXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEK 191 + Q AL S IH+P +K G P++ F T D+ A W AMEK Sbjct: 94 LVQPALESSLKKLQLDYVDLYLIHFPMALKPGETPLPKDENGKVMFDTVDLCAIWEAMEK 153 Query: 192 LHDAGKARAIGVSNFSSKKLGDLL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHL 365 DAG A++IGVSNF+ ++L +L + P +QVECHP Q+KL +FC+S + L Sbjct: 154 CKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVL 213 Query: 366 SAYSPLGSP-GTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 A+S LG+ W++ N +L++P++ ++++K ++PA +ALR+ +Q G VL KS N Sbjct: 214 VAHSALGTQRHKLWVDQNSPALLEDPVLCALAKKHKRSPALIALRYQLQRGVVVLAKSYN 273
>AK1C4_MACFA (Q95JH5) Aldo-keto reductase family 1 member C4 (EC 1.1.1.-)| (Chlordecone reductase) (EC 1.1.1.225) (CDR) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (3-alpha-HSD1) (Dihydrodiol dehydrogenase 4) (DD4) (DD-4) Length = 323 Score = 105 bits (261), Expect = 1e-22 Identities = 66/180 (36%), Positives = 102/180 (56%), Gaps = 12/180 (6%) Frame = +3 Query: 30 MCQXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEK 191 + Q AL S IH+P +K G P++ F T D+ A W AMEK Sbjct: 94 LVQPALESSLKKLQLDYVDLYLIHFPMALKPGETPLPKDENGKVMFDTVDLCAIWEAMEK 153 Query: 192 LHDAGKARAIGVSNFSSKKLGDLL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHL 365 DAG A++IGVSNF+ ++L +L + P +QVECHP Q+KL +FC+S + L Sbjct: 154 CKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVL 213 Query: 366 SAYSPLGSP-GTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 A+S LG+ W++ N +L++P++ ++++K ++PA +ALR+ +Q G VL KS N Sbjct: 214 VAHSALGTQRHKLWVDQNSPALLEDPVLCALAKKHKRSPALIALRYQLQRGVVVLAKSYN 273
>ALDR_PIG (P80276) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase)| Length = 315 Score = 105 bits (261), Expect = 1e-22 Identities = 64/155 (41%), Positives = 91/155 (58%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNP---ENFVTPD---IPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P + V PD TW AME+L D G +AIGVSNF+ ++ Sbjct: 109 IHWPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEK 168 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + PAV+Q+E HP Q KL +C+S G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I +I+ K KT AQV +R+ +Q V+PKS Sbjct: 229 EDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKS 263
>XYL1_PICGU (O94735) NADPH-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 317 Score = 104 bits (259), Expect = 2e-22 Identities = 59/140 (42%), Positives = 84/140 (60%), Gaps = 9/140 (6%) Frame = +3 Query: 141 ENFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPC 314 + F D+P TW A+EKL + GK R+IG+SNFS + DLL A++ PAV Q+E HP Sbjct: 133 DKFHYEDVPLIDTWRALEKLVEKGKIRSIGISNFSGALIQDLLRSAKIKPAVLQIEHHPY 192 Query: 315 WQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKE-------PIIISISEKLGKTPA 473 QQ +L + QS G+ ++AYS G ++ +K+ +I S++ K+ KTPA Sbjct: 193 LQQPRLVEYVQSQGIAITAYSSFGPQSFVELDHPRVKDVKPLFEHDVIKSVAGKVKKTPA 252 Query: 474 QVALRWNIQTGHSVLPKSTN 533 QV LRW Q G +V+PKS N Sbjct: 253 QVLLRWATQRGLAVIPKSNN 272
>DHB5_MOUSE (P70694) Estradiol 17 beta-dehydrogenase 5 (EC 1.1.1.-)| (17-beta-HSD 5) Length = 323 Score = 104 bits (259), Expect = 2e-22 Identities = 64/156 (41%), Positives = 93/156 (59%), Gaps = 12/156 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G N P++ + DI TW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPMAMKPGENYLPKDENGKLIYDAVDICDTWEAMEKCKDAGLAKSIGVSNFNRRQLEK 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECHP Q KL +FC+S + L AYS LGS W++ + + Sbjct: 176 ILKKPGLKYKPVCNQVECHPYLNQGKLLDFCRSKDIVLVAYSALGSHREKQWVDQSSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 L P++ S+++K +TPA +ALR+ +Q G VL KS Sbjct: 236 LDNPVLGSMAKKYNRTPALIALRYQLQRGVVVLAKS 271
>AK1C3_PONPY (Q5R7C9) Aldo-keto reductase family 1 member C3 homolog (EC| 1.-.-.-) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (3-alpha-hydroxysteroid dehydrogenase type 2) (EC 1.1.1.213) (3-alpha-HSD type 2) (Prostaglandin F synthase) Length = 323 Score = 104 bits (259), Expect = 2e-22 Identities = 62/158 (39%), Positives = 96/158 (60%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH P +K G +P + F D+ TW AME+ DAG A++IGVSNF+ ++L Sbjct: 116 IHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEECKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSP-GTTWMNGN---V 419 +L + P +QVECHP + ++KL +FC+S + L AYS LGS W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L++P++ ++++K +TPA +ALR+ +Q G VL KS N Sbjct: 236 LEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYN 273
>YDG7_SCHPO (Q10494) Probable oxidoreductase C26F1.07 in chromosome I (EC| 1.-.-.-) Length = 321 Score = 102 bits (254), Expect = 7e-22 Identities = 60/156 (38%), Positives = 87/156 (55%), Gaps = 10/156 (6%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P++ + I TW AMEKL + GK R IG+SNF+ L Sbjct: 117 IHWPVSFKTGEDKFPKDKDGNLIYEKNPIEETWKAMEKLLETGKVRHIGLSNFNDTNLER 176 Query: 258 LLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMN--GNVLKEP 431 +L VA+V PAV Q+E HP QT+ + G+H++AYSP G+ T + + +++ Sbjct: 177 ILKVAKVKPAVHQMELHPFLPQTEFVEKHKKLGIHVTAYSPFGNQNTIYESKIPKLIEHE 236 Query: 432 IIISISEKLGK--TPAQVALRWNIQTGHSVLPKSTN 533 I I++ G+ T A +A+ W I G SV+PKS N Sbjct: 237 TIQKIAKSKGEGVTGATIAVSWAITRGTSVIPKSVN 272
>XYL1_PICST (P31867) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 318 Score = 102 bits (254), Expect = 7e-22 Identities = 61/138 (44%), Positives = 81/138 (58%), Gaps = 9/138 (6%) Frame = +3 Query: 141 ENFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPC 314 +NF D+P TW A+EKL AGK R+IGVSNF L DLL A + P+V QVE HP Sbjct: 134 DNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGATIKPSVLQVEHHPY 193 Query: 315 WQQTKLHNFCQSAGVHLSAYSPLG-------SPGTTWMNGNVLKEPIIISISEKLGKTPA 473 QQ +L F QS G+ ++AYS G + G + + I +I+ K GK+PA Sbjct: 194 LQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENETIKAIAAKHGKSPA 253 Query: 474 QVALRWNIQTGHSVLPKS 527 QV LRW+ Q G +++PKS Sbjct: 254 QVLLRWSSQRGIAIIPKS 271
>AK1BA_HUMAN (O60218) Aldo-keto reductase family 1 member B10 (EC 1.1.1.-)| (Aldose reductase-like) (ARL-1) (Small intestine reductase) (SI reductase) (Aldose reductase-related protein) (ARP) (hARP) Length = 316 Score = 102 bits (253), Expect = 9e-22 Identities = 63/155 (40%), Positives = 87/155 (56%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPA------TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P++ I W AME+L D G +A+GVSNFS ++ Sbjct: 110 IHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEK 169 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 LL + P +QVECHP Q KL +C S G+ ++AYSPLGSP W + ++L Sbjct: 170 LLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLL 229 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I I+ K KT AQV +R++IQ V+PKS Sbjct: 230 EDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKS 264
>XYL2_CANTR (P87039) NADPH-dependent D-xylose reductase II,III (EC 1.1.1.-)| (XR) Length = 324 Score = 101 bits (251), Expect = 1e-21 Identities = 57/140 (40%), Positives = 81/140 (57%), Gaps = 9/140 (6%) Frame = +3 Query: 141 ENFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPC 314 +NF D+P TW A+EKL +AGK ++IG+SNF+ + DL+ A + PAV Q+E HP Sbjct: 140 DNFHYEDVPLLDTWKALEKLVEAGKIKSIGISNFTGALIYDLIRGATIKPAVLQIEHHPY 199 Query: 315 WQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNG-------NVLKEPIIISISEKLGKTPA 473 QQ KL + Q AG+ ++ YS G + + + I SI++K GK+PA Sbjct: 200 LQQPKLIEYVQKAGIAITGYSSFGPQSFLELESKRALNTPTLFEHETIKSIADKHGKSPA 259 Query: 474 QVALRWNIQTGHSVLPKSTN 533 QV LRW Q +V+PKS N Sbjct: 260 QVLLRWATQRNIAVIPKSNN 279
>P100_LEIMA (P22045) Probable reductase (EC 1.1.-.-)| Length = 284 Score = 101 bits (251), Expect = 1e-21 Identities = 60/146 (41%), Positives = 79/146 (54%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR 275 IHWP R K + + ++ +W A E+L+ K RAIGVSNF L D+LA+ Sbjct: 111 IHWP-RGKDILSKEGKKYLD-----SWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCT 164 Query: 276 VPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEK 455 V P V+QVE HP Q L FC + + + A+SPLG G +L PI+ +I K Sbjct: 165 VTPMVNQVELHPLNNQADLRAFCDAKQIKVEAWSPLG-------QGKLLSNPILSAIGAK 217 Query: 456 LGKTPAQVALRWNIQTGHSVLPKSTN 533 KT AQV LRWNIQ +PKS + Sbjct: 218 YNKTAAQVILRWNIQKNLITIPKSVH 243
>YPR1_YEAST (Q12458) Putative reductase 1 (EC 1.1.1.-)| Length = 312 Score = 100 bits (248), Expect = 3e-21 Identities = 62/182 (34%), Positives = 89/182 (48%), Gaps = 16/182 (8%) Frame = +3 Query: 36 QXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIP--------------AT 173 + ALN+S +HWP +K + P + T Sbjct: 91 EAALNKSLKRLGLDYVDLYLMHWPVPLKTDRVTDGNVLCIPTLEDGTVDIDTKEWNFIKT 150 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAVDQVECHPCWQQTKLHNFCQ 347 W M++L GK +A+GVSNFS + +LL +V PA +Q+E HP Q +L FC+ Sbjct: 151 WELMQELPKTGKTKAVGVSNFSINNIKELLESPNNKVVPATNQIEIHPLLPQDELIAFCK 210 Query: 348 SAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 G+ + AYSP GS N +LKE II +++K G PAQ+ + W+IQ G+ VL KS Sbjct: 211 EKGIVVEAYSPFGSA-----NAPLLKEQAIIDMAKKHGVEPAQLIISWSIQRGYVVLAKS 265 Query: 528 TN 533 N Sbjct: 266 VN 267
>XYL1_ASPNG (Q9P8R5) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 319 Score = 100 bits (248), Expect = 3e-21 Identities = 59/136 (43%), Positives = 80/136 (58%), Gaps = 7/136 (5%) Frame = +3 Query: 147 FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQT 326 F I TW AME L D AR+IG+SNFS++ + DLL AR+ PA Q+E HP QT Sbjct: 139 FGNATIQETWTAMESLVDKKLARSIGISNFSAQLVMDLLRYARIRPATLQIEHHPYLTQT 198 Query: 327 KLHNFCQSAGVHLSAYSPLGSPGTTWMN-GNVLKEP------IIISISEKLGKTPAQVAL 485 +L + Q G+ ++AYS G ++ N + P ++ SI+EK G+TPAQV L Sbjct: 199 RLVEYAQKEGLTVTAYSSFGPLSFLELSVQNAVDSPPLFEHQLVKSIAEKHGRTPAQVLL 258 Query: 486 RWNIQTGHSVLPKSTN 533 RW Q G +V+PKS N Sbjct: 259 RWATQRGIAVIPKSNN 274
>XYL1_TRIRE (Q876L8) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 324 Score = 100 bits (248), Expect = 3e-21 Identities = 53/133 (39%), Positives = 81/133 (60%), Gaps = 7/133 (5%) Frame = +3 Query: 153 TPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKL 332 T + TWGAME+L D G AR+IGVSN+ ++ + D L AR+ PA Q+E HP QQ L Sbjct: 143 TTTLQQTWGAMERLVDKGLARSIGVSNYQAQSVYDALIYARIKPATLQIEHHPYLQQPDL 202 Query: 333 HNFCQSAGVHLSAYSPLGSPGTTWMN-------GNVLKEPIIISISEKLGKTPAQVALRW 491 + Q+ G+ ++AYS G G ++ ++ P+I ++++K +TPAQV LRW Sbjct: 203 VSLAQTEGIVVTAYSSFGPTGFMELDMPRAKSVAPLMDSPVIKALADKHRRTPAQVLLRW 262 Query: 492 NIQTGHSVLPKST 530 Q G +V+PK++ Sbjct: 263 ATQRGIAVIPKTS 275
>AK1D1_HUMAN (P51857) 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3)| (Delta(4)-3-ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1) Length = 326 Score = 99.8 bits (247), Expect = 4e-21 Identities = 56/128 (43%), Positives = 81/128 (63%), Gaps = 6/128 (4%) Frame = +3 Query: 168 ATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVP--PAVDQVECHPCWQQTKLHNF 341 ATW AME DAG +++GVSNF+ ++L +L + P +QVECHP + Q KL F Sbjct: 149 ATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKF 208 Query: 342 CQSAGVHLSAYSPLG-SPGTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGH 509 CQ + ++AYSPLG S W+N + +LK+ ++ S+ ++ KT AQ+ LR+NIQ G Sbjct: 209 CQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGV 268 Query: 510 SVLPKSTN 533 V+PKS N Sbjct: 269 VVIPKSFN 276
>XYL1_CANTR (O13283) NAD(P)H-dependent D-xylose reductase I,II (EC 1.1.1.-)| (XR) Length = 324 Score = 99.4 bits (246), Expect = 6e-21 Identities = 57/140 (40%), Positives = 80/140 (57%), Gaps = 9/140 (6%) Frame = +3 Query: 141 ENFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPC 314 +NF D+P TW A+EKL +AGK ++IG+SNF+ + DL+ A + PAV Q+E HP Sbjct: 140 DNFHYEDVPLLDTWKALEKLVEAGKIKSIGISNFTGALIYDLIRGATIKPAVLQIEHHPY 199 Query: 315 WQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNG-NVLKEPIIIS------ISEKLGKTPA 473 QQ KL + Q AG+ ++ YS G + L P + I++K GK+PA Sbjct: 200 LQQPKLIEYVQKAGIAITGYSSFGPQSFLELESKRALNTPTLFEHETIKLIADKHGKSPA 259 Query: 474 QVALRWNIQTGHSVLPKSTN 533 QV LRW Q +V+PKS N Sbjct: 260 QVLLRWATQRNIAVIPKSNN 279
>ALD2_CRIGR (O08782) Aldose reductase-related protein 2 (EC 1.1.1.21) (AR)| (Aldehyde reductase) (Aldo-keto reductase) Length = 315 Score = 99.0 bits (245), Expect = 7e-21 Identities = 61/155 (39%), Positives = 88/155 (56%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPE----NFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP ++ G P+ N +T I W ME+L D G +A+GVSNF+ ++ Sbjct: 109 IHWPQGLQPGKELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIER 168 Query: 258 LLAVARVP--PAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWM---NGNVL 422 +L + P +QVECHP Q KL +C S G+ ++AYSPLGSP W + ++L Sbjct: 169 ILNKPGLKHKPVTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I I+ K KT AQV +R++IQ V+PKS Sbjct: 229 EDPKIKEIAAKHKKTSAQVLIRFHIQRNVVVIPKS 263
>ALDX_SPOSA (P27800) Aldehyde reductase 1 (EC 1.1.1.2) (Aldehyde reductase I)| (Alcohol dehydrogenase [NADP+]) (ALR) Length = 322 Score = 98.2 bits (243), Expect = 1e-20 Identities = 54/119 (45%), Positives = 75/119 (63%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQS 350 TW AM KL D GK +AIGVSNF +K + ++ V P+V+Q+E HP Q +L ++ Sbjct: 141 TWKAMVKLLDTGKVKAIGVSNFDAKMVDAIIEATGVTPSVNQIERHPLLLQPELIAHHKA 200 Query: 351 AGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 +H++AYSPLG+ T +++ P I I+EK G TPAQV + W I GHSV+PKS Sbjct: 201 KNIHITAYSPLGN--NTVGAPLLVQHPEIKRIAEKNGCTPAQVLIAWAIVGGHSVIPKS 257
>AK1E1_MOUSE (Q9DCT1) Aldo-keto reductase family 1 member E1 (EC 1.1.1.-)| Length = 301 Score = 97.4 bits (241), Expect = 2e-20 Identities = 59/152 (38%), Positives = 85/152 (55%), Gaps = 8/152 (5%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPA------TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP K G + P + IP+ TW AME L G + +GVSNF+ ++L Sbjct: 101 IHWPMGFKPGEKDIPLDRNGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNHEQLER 160 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEP 431 LL RV P +Q+ECHP Q KL +FC V ++AY PLG G + +++ + Sbjct: 161 LLDKPGLRVRPITNQIECHPYLNQKKLIDFCHKRNVSVTAYRPLGGSGGGF---HLMDDT 217 Query: 432 IIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 +I I++K GK+PAQ+ +R+ IQ V+PKS Sbjct: 218 VIRKIAKKHGKSPAQILIRFQIQRNLIVIPKS 249
>AK1D1_MOUSE (Q8VCX1) 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.99.6)| (Delta(4)-3-ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1) Length = 325 Score = 97.4 bits (241), Expect = 2e-20 Identities = 53/126 (42%), Positives = 80/126 (63%), Gaps = 6/126 (4%) Frame = +3 Query: 168 ATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAVDQVECHPCWQQTKLHNF 341 ATW A+E DAG +++GVSNF+ ++L +L + P +QVECHP + QTKL F Sbjct: 148 ATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVTNQVECHPYFTQTKLLKF 207 Query: 342 CQSAGVHLSAYSPLGS-PGTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGH 509 CQ + + A+SPLG+ +W+N + +L + ++ S+ +K KT AQ+ LR+NIQ G Sbjct: 208 CQQHDIVIVAHSPLGTCRNPSWVNVSSPPLLNDELLTSLGKKYNKTQAQIVLRFNIQRGI 267 Query: 510 SVLPKS 527 V+PKS Sbjct: 268 VVIPKS 273
>AK1D1_RABIT (Q9TV64) 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.99.6)| (Delta(4)-3-ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1) Length = 326 Score = 97.4 bits (241), Expect = 2e-20 Identities = 55/128 (42%), Positives = 80/128 (62%), Gaps = 6/128 (4%) Frame = +3 Query: 168 ATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVP--PAVDQVECHPCWQQTKLHNF 341 ATW A+E DAG +++GVSNF+ ++L LL + P +QVECHP + Q KL F Sbjct: 149 ATWEALEACKDAGLVKSLGVSNFNRQQLELLLNKPGLKHKPVCNQVECHPYFTQPKLLKF 208 Query: 342 CQSAGVHLSAYSPLGS-PGTTWMNGN---VLKEPIIISISEKLGKTPAQVALRWNIQTGH 509 CQ + + AYSPLG+ W+N + +LK+ ++ S+ +K KT AQ+ LR+N+Q G Sbjct: 209 CQQHDIIIVAYSPLGTCRNPMWVNTSLPPLLKDTLLNSLGKKYKKTAAQIVLRFNVQRGV 268 Query: 510 SVLPKSTN 533 V+PKS N Sbjct: 269 VVIPKSFN 276
>CRO_RANCA (P17264) Rho crystallin| Length = 323 Score = 95.1 bits (235), Expect = 1e-19 Identities = 58/156 (37%), Positives = 89/156 (57%), Gaps = 12/156 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTP------DIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP +K ++P + P D+ ATW A+E DAG R++GVSNF+ ++L Sbjct: 116 MHWPVSLKPSGASDPSDKDKPFIYDNVDLCATWEALEARKDAGLVRSLGVSNFNRRQLER 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECH Q KLH++C+S + L YS LGS W++ + + Sbjct: 176 ILNKPGLKYKPVCNQVECHVYLNQNKLHSYCKSKDIVLVTYSVLGSHRDRNWVDLSLPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 L +PI+ I+ K +T A+VA+R+ +Q G VL KS Sbjct: 236 LDDPILNKIAAKYNRTSAEVAMRFILQKGIVVLAKS 271
>DIDH_RAT (P23457) 3-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.213)| (3-alpha-HSD) (Hydroxyprostaglandin dehydrogenase) Length = 322 Score = 94.7 bits (234), Expect = 1e-19 Identities = 60/158 (37%), Positives = 92/158 (58%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P ++ G P + F T DI TW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLER 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSP-GTTWMNGN---V 419 +L + P +QVECH Q+K+ ++C+S + L +Y LGS TW++ + Sbjct: 176 ILNKPGLKYKPVCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L +P++ +I++K +TPA VALR+ +Q G L +S N Sbjct: 236 LDDPVLCAIAKKYKQTPALVALRYQLQRGVVPLIRSFN 273
>CRO_RANTE (P02532) Rho crystallin| Length = 323 Score = 94.4 bits (233), Expect = 2e-19 Identities = 56/156 (35%), Positives = 89/156 (57%), Gaps = 12/156 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTP------DIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP +K ++P + P D+ ATW A+E DAG R++GVSNF+ ++L Sbjct: 116 MHWPVSLKPSGASDPSDKDKPFIYDNVDLCATWEALEARKDAGLVRSLGVSNFNRRQLER 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS-PGTTWMNGN---V 419 +L + P +QVECH Q KLH++C+S + L YS LGS W++ + + Sbjct: 176 ILNKPGLKYKPVCNQVECHVYLNQNKLHSYCKSKDIVLVTYSVLGSHRDRNWVDLSLPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 L +PI+ ++ K +T A++A+R+ +Q G VL KS Sbjct: 236 LDDPILNKVAAKYNRTSAEIAMRFILQKGIVVLAKS 271
>XYL1_PACTA (P78736) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 318 Score = 94.4 bits (233), Expect = 2e-19 Identities = 57/139 (41%), Positives = 77/139 (55%), Gaps = 9/139 (6%) Frame = +3 Query: 141 ENFVTPDIPA--TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPC 314 + F+ D+P TW AME L D G ++IGVSN S L DL+ AR+ PA Q+E HP Sbjct: 134 DKFIYEDVPIIETWRAMENLVDEGLVKSIGVSNVSGGLLEDLIKAARIKPASLQIEHHPY 193 Query: 315 WQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLK--EPI-----IISISEKLGKTPA 473 QQ KL + Q G+ ++ YS G + K +P+ I +I+ K GKTP Sbjct: 194 LQQNKLVEYAQLKGIVVTGYSNFGPLSFLELGNETAKKTQPLYENKTITTIAAKHGKTPF 253 Query: 474 QVALRWNIQTGHSVLPKST 530 QV LRW Q G +++PKST Sbjct: 254 QVLLRWVNQRGIAIIPKST 272
>S6PD_MALDO (P28475) NADP-dependent D-sorbitol-6-phosphate dehydrogenase (EC| 1.1.1.200) (Aldose-6-phosphate reductase [NADPH]) (NADP-S6PDH) Length = 310 Score = 94.4 bits (233), Expect = 2e-19 Identities = 52/130 (40%), Positives = 76/130 (58%), Gaps = 3/130 (2%) Frame = +3 Query: 150 VTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTK 329 VT + TW MEK G R+IG+SN+ D LA +++ PAV Q E HP +Q+ Sbjct: 135 VTISLQQTWEGMEKTVSLGLVRSIGLSNYELFLTRDCLAYSKIKPAVSQFETHPYFQRDS 194 Query: 330 LHNFCQSAGVHLSAYSPLGSPGTTW-MNGNV--LKEPIIISISEKLGKTPAQVALRWNIQ 500 L FC GV +A++PLG M G+V L +P++ +++K GK+ AQ+ LRW IQ Sbjct: 195 LVKFCMKHGVLPTAHTPLGGAAANKDMFGSVSPLDDPVLNDVAKKYGKSVAQICLRWGIQ 254 Query: 501 TGHSVLPKST 530 +V+PKS+ Sbjct: 255 RKTAVIPKSS 264
>ALD2_MOUSE (P45377) Aldose reductase-related protein 2 (EC 1.1.1.21) (AR)| (Aldehyde reductase) (Fibroblast growth factor-regulated protein) (FR-1 protein) Length = 315 Score = 91.3 bits (225), Expect = 2e-18 Identities = 58/155 (37%), Positives = 86/155 (55%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPA------TWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IHWP ++ G P++ + + W ME+L D G +A+GVSNF+ ++ Sbjct: 109 IHWPQGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIER 168 Query: 258 LLAVARVP--PAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGS---PGTTWMNGNVL 422 LL + P +QVECHP Q KL +C S G+ ++AYSPLGS P + ++L Sbjct: 169 LLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLL 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 ++P I I+ K KT AQV +R++IQ V+PKS Sbjct: 229 EDPKIKEIAAKHEKTSAQVLIRFHIQRNVVVIPKS 263
>YOF5_CAEEL (Q09632) Probable oxidoreductase ZK1290.5 in chromosome II (EC| 1.-.-.-) Length = 321 Score = 90.9 bits (224), Expect = 2e-18 Identities = 47/121 (38%), Positives = 67/121 (55%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQS 350 TW ME L++ R+IGVSN+S + L +LL A + P +QVE HP + Q L N+C Sbjct: 124 TWRQMELLYEDEHVRSIGVSNYSIEDLDELLEFASILPHANQVELHPWFHQADLKNYCDE 183 Query: 351 AGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 G+ Y PL G L++ + I+ K K+PAQ+ LRW+IQ +PKST Sbjct: 184 LGILTMGYCPLA-------KGKYLEDETLCKIASKYQKSPAQICLRWSIQQNVPTVPKST 236 Query: 531 N 533 + Sbjct: 237 D 237
>AK1D1_RAT (P31210) 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.99.6)| (Delta(4)-3-ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1) Length = 326 Score = 89.7 bits (221), Expect = 4e-18 Identities = 58/158 (36%), Positives = 89/158 (56%), Gaps = 13/158 (8%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 I P K G P++ + ++ ATW A+E DAG +++GVSNF+ ++L Sbjct: 118 IEMPMAFKPGEEFYPKDENGRVIYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLEV 177 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVH-LSAYSPLGS-PGTTWMNGN--- 416 +L + P +QVECHP + QTKL S+ + AYSPLG+ W+N + Sbjct: 178 ILNKPGLKYKPVTNQVECHPYFTQTKLLEVSASSMTSFIVAYSPLGTCRNPLWVNVSSPP 237 Query: 417 VLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 +LK+ ++ S+ +K KT AQ+ LR++IQ G V+PKST Sbjct: 238 LLKDELLTSLGKKYNKTQAQIVLRFDIQRGLVVIPKST 275
>AKC1H_MOUSE (Q8K023) Aldo-keto reductase family 1 member C18 (EC 1.1.-.-)| (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) Length = 323 Score = 89.7 bits (221), Expect = 4e-18 Identities = 56/158 (35%), Positives = 87/158 (55%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G P++ F T D+ TW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN----V 419 +L + P +QVECH Q+KL +C+ + L AY LG+ + + Sbjct: 176 ILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L +P++ ++++K +TPA +ALR+ + G L KS N Sbjct: 236 LDDPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFN 273
>XYL1_CANPA (Q6Y0Z3) NADH-dependent D-xylose reductase (EC 1.1.1.175) (XR)| Length = 324 Score = 89.4 bits (220), Expect = 6e-18 Identities = 49/128 (38%), Positives = 75/128 (58%), Gaps = 7/128 (5%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQS 350 TW A+EKL D G A++IG+SNFS++ + DL+ + P Q+E HP Q KL + Q Sbjct: 152 TWRALEKLVDQGLAKSIGISNFSAQLIYDLIRGCTIKPVALQIEHHPYLTQPKLVEYVQL 211 Query: 351 AGVHLSAYSPLGSPGTTWMNGN-------VLKEPIIISISEKLGKTPAQVALRWNIQTGH 509 + ++ YS G M+ +L+EP + SI++K GK+PAQV LR+ Q G Sbjct: 212 HDIQITGYSSFGPQSFLEMDLKRALDTPVLLEEPTVKSIADKHGKSPAQVLLRYQTQRGI 271 Query: 510 SVLPKSTN 533 +V+P+S + Sbjct: 272 AVIPRSNS 279
>AKC1H_RAT (P51652) Aldo-keto reductase family 1 member C18 (EC 1.1.-.-)| (20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) (HSD1) Length = 323 Score = 88.2 bits (217), Expect = 1e-17 Identities = 56/158 (35%), Positives = 87/158 (55%), Gaps = 12/158 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 IH+P +K G P++ T D+ TW AMEK DAG A++IGVSNF+ ++L Sbjct: 116 IHFPVSLKPGDELLPQDEHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEK 175 Query: 258 LLAVARVP--PAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN----V 419 +L + P +QVECH Q+KL +C+ + L AY LG+ + + Sbjct: 176 ILNKPGLKHRPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 L +PI+ ++++K +TPA +ALR+ ++ G L KS N Sbjct: 236 LDDPILCTMAKKYKRTPALIALRYQLERGIVTLVKSFN 273
>XYL1_KLULA (P49378) NAD(P)H-dependent D-xylose reductase (EC 1.1.1.-) (XR)| Length = 329 Score = 88.2 bits (217), Expect = 1e-17 Identities = 50/127 (39%), Positives = 71/127 (55%), Gaps = 7/127 (5%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQS 350 TW A+EKL D GK +++G+SNFS + DLL AR+ P Q+E HP Q +L + ++ Sbjct: 154 TWRALEKLVDQGKIKSLGISNFSGALIQDLLRGARIKPVALQIEHHPYLTQERLIKYVKN 213 Query: 351 AGVHLSAYSPLGSPGTTWM-NGNVLKEPIII------SISEKLGKTPAQVALRWNIQTGH 509 AG+ + AYS G + N L P + SI+ K TP QV LRW Q G Sbjct: 214 AGIQVVAYSSFGPVSFLELENKKALNTPTLFEHDTIKSIASKHKVTPQQVLLRWATQNGI 273 Query: 510 SVLPKST 530 +++PKS+ Sbjct: 274 AIIPKSS 280
>AK1CD_MOUSE (Q8VC28) Aldo-keto reductase family 1 member C13 (EC 1.1.1.-)| Length = 323 Score = 87.0 bits (214), Expect = 3e-17 Identities = 54/156 (34%), Positives = 87/156 (55%), Gaps = 12/156 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +H+P +K G N+ P N T D TW +E+ DAG ++IGVSNF+ ++L Sbjct: 116 MHYPVPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLER 175 Query: 258 LLAVA--RVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPG-TTWMNGN---V 419 +L + P +QVECH Q KL ++C+S + L AY LG+ W++ N + Sbjct: 176 ILNKPGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 L +P++ +++K ++PA +ALR+ IQ G L +S Sbjct: 236 LNDPVLCDVAKKNKRSPALIALRYLIQRGIVPLAQS 271
>ALD1_MOUSE (P21300) Aldose reductase-related protein 1 (EC 1.1.1.21) (AR)| (Aldehyde reductase) (VAS deferens androgen-dependent protein) (MVDP) (Aldo-keto reductase family 1 member B7) Length = 315 Score = 87.0 bits (214), Expect = 3e-17 Identities = 55/155 (35%), Positives = 82/155 (52%), Gaps = 11/155 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +HWP + G P++ W AME+L D G +A+G+SNF+ ++ Sbjct: 109 VHWPQGFQAGNALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIER 168 Query: 258 LLAVARVP--PAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGN---VL 422 LL + P +Q+E HP Q KL +CQS G+ ++AYSPLGSP + V+ Sbjct: 169 LLNKPGLKHKPVTNQIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVM 228 Query: 423 KEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + P I I+ K KT AQV +R+++Q V+PKS Sbjct: 229 EIPKIKEIAAKHKKTVAQVLIRFHVQRNVVVIPKS 263
>MORA_PSEPU (Q02198) Morphine 6-dehydrogenase (EC 1.1.1.218) (Naloxone| reductase) Length = 295 Score = 86.7 bits (213), Expect = 4e-17 Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 6/170 (3%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 A +ES +HWP + T + W A EK+ G+ARAI Sbjct: 90 AFDESLGRLGLDYVDLYLLHWPTKDWNATIQS------------WKAAEKILGDGRARAI 137 Query: 222 GVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLG---SP 392 GV NF +L +L+A + V PAV+Q+E HP + Q L ++ G+ A+SP+G + Sbjct: 138 GVCNFLEDQLDELIAASDVVPAVNQIELHPYFAQKPLLAKNRALGIVTEAWSPIGGAIND 197 Query: 393 GTTWMNG---NVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKSTN 533 G +G + L +P+I +I+E G++ AQV LRW+ Q +PKS N Sbjct: 198 GDGDNHGGRKHPLTDPVITTIAEAHGRSAAQVILRWHFQNDVVAIPKSVN 247
>DTDH_MUCMU (Q01213) 4-dihydromethyl-trisporate dehydrogenase (EC 1.1.1.-)| (4-dihydromethyl-TA dehydrogenase) Length = 321 Score = 85.1 bits (209), Expect = 1e-16 Identities = 49/137 (35%), Positives = 75/137 (54%), Gaps = 8/137 (5%) Frame = +3 Query: 147 FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQT 326 F I W +EK+ DAG AR IGV+NF+ + + DLL AR+ PAV Q+E HP Q Sbjct: 141 FEQSPIHECWAELEKIVDAGLARNIGVANFNCQAILDLLTYARIKPAVLQIELHPYLPQE 200 Query: 327 KLHNFCQSAGVHLSAYSPLG--------SPGTTWMNGNVLKEPIIISISEKLGKTPAQVA 482 +L + + G+ ++AYS G G T+ ++L+ + S+++K + QV Sbjct: 201 RLVKWVKEQGIQITAYSSFGPTSYVDLTESGKTYT--SLLEHASVKSVADKHNVSTGQVL 258 Query: 483 LRWNIQTGHSVLPKSTN 533 LRW + +V+PKS N Sbjct: 259 LRWALDREFAVIPKSVN 275
>DKGB_CORSS (P15339) 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274)| (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (AKR5D) Length = 276 Score = 83.2 bits (204), Expect = 4e-16 Identities = 52/146 (35%), Positives = 71/146 (48%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR 275 IHWP NP D TW M +AG R+IGVSNF+ L L+ Sbjct: 107 IHWP---------NPSVGRWLD---TWRGMIDAREAGLVRSIGVSNFTEPMLKTLIDETG 154 Query: 276 VPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEK 455 V PAV+QVE HP + Q L F G+ ++SPL +L E ++ ++ Sbjct: 155 VTPAVNQVELHPYFPQAALRAFHDEHGIRTESWSPLA------RRSELLTEQLLQELAVV 208 Query: 456 LGKTPAQVALRWNIQTGHSVLPKSTN 533 G TP QV LRW++Q G + +PKS + Sbjct: 209 YGVTPTQVVLRWHVQLGSTPIPKSAD 234
>AK1CD_MESAU (P82809) Aldo-keto reductase family 1 member C13 (EC 1.1.1.-)| (Morphine 6-dehydrogenase) (EC 1.1.1.218) Length = 322 Score = 82.4 bits (202), Expect = 7e-16 Identities = 52/156 (33%), Positives = 88/156 (56%), Gaps = 12/156 (7%) Frame = +3 Query: 96 IHWPFRVKKGTNNNPEN------FVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGD 257 +H+P +K G N+ P + T D ATW A+EK DAG ++IGVSNF+ ++L Sbjct: 116 MHYPVPMKAGDNDFPLDEQGKLLLDTVDFCATWEALEKXXDAGLVKSIGVSNFNMRQLER 175 Query: 258 LL--AVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPG-TTWMNGN---V 419 +L + P +QVECH Q+KL ++C+S + L A+ LG+ W++ + + Sbjct: 176 ILNKPGLKYKPVCNQVECHVYNNQSKLLDYCKSKDIVLVAFGALGTQRYKEWVDQDSPVL 235 Query: 420 LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 L +P++ ++ ++PA +ALR+ +Q G L +S Sbjct: 236 LNDPVLCGGAKXXXRSPALIALRYLVQRGVVPLAQS 271
>DKGA_SALTI (P58744) 2,5-diketo-D-gluconic acid reductase A (EC 1.1.1.274)| (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) Length = 275 Score = 82.0 bits (201), Expect = 9e-16 Identities = 42/118 (35%), Positives = 63/118 (53%) Frame = +3 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSA 353 W M L G ++IGV NF L L+ VPP ++Q+E HP QQ +LH + Sbjct: 120 WKGMIALQKEGLVKSIGVCNFQIHHLQRLIDETGVPPVINQIELHPLMQQRQLHAXNATH 179 Query: 354 GVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + ++SPL G V + +I +++K GKTPAQ+ +RW++ G V+PKS Sbjct: 180 KIQTESWSPLAQGGE-----GVFDQKVIRELADKYGKTPAQIVIRWHLDCGLVVIPKS 232
>DKGA_ECOLI (Q46857) 2,5-diketo-D-gluconic acid reductase A (EC 1.1.1.274)| (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) Length = 275 Score = 80.9 bits (198), Expect = 2e-15 Identities = 41/118 (34%), Positives = 65/118 (55%) Frame = +3 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSA 353 W M +L G ++IGV NF L L+ V P ++Q+E HP QQ +LH + + Sbjct: 120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATH 179 Query: 354 GVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + ++SPL G V + +I +++K GKTPAQ+ +RW++ +G V+PKS Sbjct: 180 KIQTESWSPLAQGGK-----GVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKS 232
>DKGA_ECO57 (Q8XBT6) 2,5-diketo-D-gluconic acid reductase A (EC 1.1.1.274)| (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) Length = 275 Score = 80.9 bits (198), Expect = 2e-15 Identities = 41/118 (34%), Positives = 65/118 (55%) Frame = +3 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSA 353 W M +L G ++IGV NF L L+ V P ++Q+E HP QQ +LH + + Sbjct: 120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATH 179 Query: 354 GVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + ++SPL G V + +I +++K GKTPAQ+ +RW++ +G V+PKS Sbjct: 180 KIQTESWSPLAQGGK-----GVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKS 232
>DKGA_SALTY (Q8ZM06) 2,5-diketo-D-gluconic acid reductase A (EC 1.1.1.274)| (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) Length = 275 Score = 79.7 bits (195), Expect = 5e-15 Identities = 41/118 (34%), Positives = 63/118 (53%) Frame = +3 Query: 174 WGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSA 353 W M L G ++IGV NF L L+ V P ++Q+E HP QQ +LH + + Sbjct: 120 WKGMIALQKEGLVKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATH 179 Query: 354 GVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + ++SPL G V + +I +++K GKTPAQ+ +RW++ G V+PKS Sbjct: 180 KIQTESWSPLAQGGE-----GVFDQKVIRELADKYGKTPAQIVIRWHLDCGLVVIPKS 232
>DKGA_CORSC (P06632) 2,5-diketo-D-gluconic acid reductase A (EC 1.1.1.274)| (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) Length = 277 Score = 79.3 bits (194), Expect = 6e-15 Identities = 54/162 (33%), Positives = 79/162 (48%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 A+ ES +HWP +N+V W M +L AG R+I Sbjct: 88 AIAESLAKLALDQVDLYLVHWPTPAA-------DNYVH-----AWEKMIELRAAGLTRSI 135 Query: 222 GVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTT 401 GVSN L ++A V PAV+Q+E HP +QQ ++ ++ + V + ++ PLG G Sbjct: 136 GVSNHLVPHLERIVAATGVVPAVNQIELHPAYQQREITDWAAAHDVKIESWGPLGQ-GKY 194 Query: 402 WMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 + G EP+ + + GKTPAQ LRW++Q G V PKS Sbjct: 195 DLFG---AEPVTAAAAAH-GKTPAQAVLRWHLQKGFVVFPKS 232
>ARA1_YEAST (P38115) D-arabinose dehydrogenase [NAD(P)+] heavy chain (EC| 1.1.1.117) Length = 344 Score = 79.0 bits (193), Expect = 8e-15 Identities = 49/128 (38%), Positives = 72/128 (56%), Gaps = 3/128 (2%) Frame = +3 Query: 159 DIPATWGAMEKLH---DAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTK 329 D T+ +EK++ + + RAIGVSNFS + L L+ RV P V+QVE HP Q + Sbjct: 166 DYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQME 225 Query: 330 LHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGH 509 L FC + L+AYSPLGS G LK P++ ++EK T + + ++I+ G Sbjct: 226 LRKFCFMHDILLTAYSPLGSHGAP-----NLKIPLVKKLAEKYNVTGNDLLISYHIRQGT 280 Query: 510 SVLPKSTN 533 V+P+S N Sbjct: 281 IVIPRSLN 288
>DKGA_YERPE (Q8ZI40) 2,5-diketo-D-gluconic acid reductase A (EC 1.1.1.274)| (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) Length = 277 Score = 78.6 bits (192), Expect = 1e-14 Identities = 49/164 (29%), Positives = 78/164 (47%) Frame = +3 Query: 36 QXALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKAR 215 Q AL S IHWP + +++V+ W + L + G R Sbjct: 86 QQALETSLQKLQLDYVDLYLIHWP-------DPKQDHYVS-----AWRELVTLKEQGLIR 133 Query: 216 AIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPG 395 +IGV NF L L+ + P V+Q+E HP QQ +LH + + + ++SPL G Sbjct: 134 SIGVCNFHIPHLQRLIDETGIAPTVNQIELHPLLQQRQLHAWNATHHIATESWSPLAQGG 193 Query: 396 TTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 V + II ++++ KTPAQ+ +RW++ +G V+PKS Sbjct: 194 K-----GVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKS 232
>YJ66_YEAST (P47137) Probable oxidoreductase YJR096W (EC 1.-.-.-)| Length = 282 Score = 75.9 bits (185), Expect = 7e-14 Identities = 38/121 (31%), Positives = 71/121 (58%), Gaps = 2/121 (1%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVP--PAVDQVECHPCWQQTKLHNFC 344 TW AM++ D G ++IGVSN+ K + +LL + P V+Q+E P + +L ++C Sbjct: 127 TWRAMQEAVDEGLVKSIGVSNYGKKHIDELLNWPELKHKPVVNQIEISPWIMRQELADYC 186 Query: 345 QSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPK 524 +S G+ + A++PL +G + P ++ + +++ + P QV +RW++Q G+ LPK Sbjct: 187 KSKGLVVEAFAPL-------CHGYKMTNPDLLKVCKEVDRNPGQVLIRWSLQHGYLPLPK 239 Query: 525 S 527 + Sbjct: 240 T 240
>GRE3_YEAST (P38715) NADPH-dependent aldose reductase GRE3 (EC 1.1.1.21)| (NADPH-dependent aldo-keto reductase GRE3) (NADPH-dependent methylglyoxal reductase GRE3) (EC 1.1.1.-) (Xylose reductase) (EC 1.1.1.-) (Genes de respuesta a estres protein 3) Length = 327 Score = 71.6 bits (174), Expect = 1e-12 Identities = 45/128 (35%), Positives = 65/128 (50%), Gaps = 8/128 (6%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQS 350 T+ A+E+ D G ++IGVSNF + DLL R+ P Q+E HP Q L FC+ Sbjct: 151 TYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHHPYLTQEHLVEFCKL 210 Query: 351 AGVHLSAYSPLGSPGTTWMNGNVLK-------EPIIISISEK-LGKTPAQVALRWNIQTG 506 + + AYS G M+ + K +I +S+ G T +QV LRW Q G Sbjct: 211 HDIQVVAYSSFGPQSFIEMDLQLAKTTPTLFENDVIKKVSQNHPGSTTSQVLLRWATQRG 270 Query: 507 HSVLPKST 530 +V+PKS+ Sbjct: 271 IAVIPKSS 278
>DKGB_YERPE (Q8ZH36) 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274)| (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (AKR5D) Length = 267 Score = 69.3 bits (168), Expect = 6e-12 Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 1/164 (0%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 +L ES IHWP +P + V+ + + K G R I Sbjct: 78 SLRESIQKLKTDYVDLTLIHWP---------SPNDEVS--VAEFMSELLKAKGLGLTRQI 126 Query: 222 GVSNFSSKKLGDLLA-VARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGT 398 G+SNF+ + +A V A +Q+E P Q + +F + G+ +++Y L Sbjct: 127 GISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQNRNVVDFAKQNGIAVTSYMTLAY--- 183 Query: 399 TWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 G L EP+I +I+E+ G TPAQV L W +Q G+ V+P ST Sbjct: 184 ----GKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSST 223
>DKGB_SALTY (Q8ZRM7) 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274)| (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (AKR5D) Length = 267 Score = 66.6 bits (161), Expect = 4e-11 Identities = 48/164 (29%), Positives = 74/164 (45%), Gaps = 1/164 (0%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 +L ES IHWP G + E F+ A+ + G R I Sbjct: 78 SLKESLKKLRTDYVDLTLIHWP---SPGDAVSVEEFMQ--------ALLEAKKQGLTREI 126 Query: 222 GVSNFSSKKLGDLLAVARVPP-AVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGT 398 G+SNF+ + +A A +Q+E P Q K+ ++ ++ G+H+++Y L Sbjct: 127 GISNFTIPLMEKAIAAVGADNIATNQIELSPYLQNRKVVDWAKAHGIHITSYMTLAY--- 183 Query: 399 TWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 G LK+ +I I+ K TPAQV L W + G+SV+P ST Sbjct: 184 ----GKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSST 223
>DKGB_SALTI (Q8Z988) 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274)| (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (AKR5D) Length = 267 Score = 64.7 bits (156), Expect = 2e-10 Identities = 47/164 (28%), Positives = 73/164 (44%), Gaps = 1/164 (0%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 +L ES IHWP G + E F+ A+ + G R I Sbjct: 78 SLKESLKKLRTDYVDLTLIHWP---SPGDAVSVEEFMQ--------ALLEAKKQGLTREI 126 Query: 222 GVSNFSSKKLGDLLAVARVPP-AVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGT 398 G+SNF+ + +A A +Q+E P Q K+ ++ ++ G+H+++Y L Sbjct: 127 GISNFTIPLMEKAIAAVGADHIATNQIELSPYLQNRKVVDWAKAHGIHITSYMTLAY--- 183 Query: 399 TWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 G LK+ +I I+ K TP QV L W + G+SV+P ST Sbjct: 184 ----GKALKDEVIARIAVKHNATPVQVILAWAMGEGYSVIPSST 223
>DKGB_ECOLI (P30863) 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274)| (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (AKR5D) Length = 267 Score = 64.7 bits (156), Expect = 2e-10 Identities = 48/164 (29%), Positives = 74/164 (45%), Gaps = 1/164 (0%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 +L ES IHWP +P + V+ + A+ + G R I Sbjct: 78 SLKESLQKLRTDYVDLTLIHWP---------SPNDEVS--VEEFMQALLEAKKQGLTREI 126 Query: 222 GVSNFSSKKLGDLLA-VARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGT 398 G+SNF+ + +A V A +Q+E P Q K+ + + G+H+++Y L Sbjct: 127 GISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRKVVAWAKQHGIHITSYMTLAY--- 183 Query: 399 TWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 G LK+ +I I+ K TPAQV L W + G+SV+P ST Sbjct: 184 ----GKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSST 223
>DKGB_ECO57 (Q8X7Z7) 2,5-diketo-D-gluconic acid reductase B (EC 1.1.1.274)| (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (AKR5D) Length = 267 Score = 64.7 bits (156), Expect = 2e-10 Identities = 48/164 (29%), Positives = 74/164 (45%), Gaps = 1/164 (0%) Frame = +3 Query: 42 ALNESXXXXXXXXXXXXXIHWPFRVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAI 221 +L ES IHWP +P + V+ + A+ + G R I Sbjct: 78 SLKESLQKLRTDYVDLTLIHWP---------SPNDEVS--VEEFMQALLEAKKEGLTREI 126 Query: 222 GVSNFSSKKLGDLLA-VARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGT 398 G+SNF+ + +A V A +Q+E P Q K+ + + G+H+++Y L Sbjct: 127 GISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRKVVAWAKQHGIHITSYMTLAY--- 183 Query: 399 TWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKST 530 G LK+ +I I+ K TPAQV L W + G+SV+P ST Sbjct: 184 ----GKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSST 223
>YEAE_ECOLI (P76234) Hypothetical protein yeaE| Length = 284 Score = 41.2 bits (95), Expect = 0.002 Identities = 40/126 (31%), Positives = 58/126 (46%), Gaps = 7/126 (5%) Frame = +3 Query: 171 TWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPP----AVDQVECHPCWQ--QTKL 332 T AMEKL GK R GVSN D+ + ++P A +QV H + + L Sbjct: 123 TVAAMEKLIAQGKIRRWGVSNLD---YADMQELWQLPGGNQCATNQVLYHLGSRGIEYDL 179 Query: 333 HNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNI-QTGH 509 +CQ + + AYSPL G + +LK ++ I+ + AQV L W I G Sbjct: 180 LPWCQQQQMPVMAYSPLAQAGR--LRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGV 237 Query: 510 SVLPKS 527 +PK+ Sbjct: 238 MAIPKA 243
>MORA_RABIT (P82810) Morphine 6-dehydrogenase (EC 1.1.1.218) (Fragments)| Length = 125 Score = 39.3 bits (90), Expect = 0.007 Identities = 33/105 (31%), Positives = 46/105 (43%) Frame = +3 Query: 213 RAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSP 392 ++IGVSNF+ K++ + QVE HP Q+K + L AYS LGS Sbjct: 40 KSIGVSNFNHKRVXN------------QVEXHPYLNQSK--------DIVLVAYSALGSS 79 Query: 393 GTTWMNGNVLKEPIIISISEKLGKTPAQVALRWNIQTGHSVLPKS 527 W ++PA +ALR+ +Q G VL KS Sbjct: 80 RDPWK------------------QSPALIALRYQLQRGVVVLAKS 106
>GS69_BACSU (P80874) General stress protein 69 (EC 1.1.1.-) (GSP69) (AKR11B)| Length = 331 Score = 38.5 bits (88), Expect = 0.012 Identities = 20/37 (54%), Positives = 26/37 (70%) Frame = +3 Query: 162 IPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVA 272 I T M++L+DAGK RAIGVSNFS +++ AVA Sbjct: 133 IEETAEVMKELYDAGKIRAIGVSNFSIEQMDTFRAVA 169
>YAKC_SCHPO (Q09923) Aldo-keto reductase yakc [NADP+] (EC 1.1.1.-)| Length = 340 Score = 38.1 bits (87), Expect = 0.015 Identities = 37/144 (25%), Positives = 60/144 (41%), Gaps = 29/144 (20%) Frame = +3 Query: 177 GAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTK-----LHNF 341 GA++K +AGK R IG+S S+ + AV P + QVE P + + + Sbjct: 139 GALKKCVEAGKIRYIGLSECSANTIRRAAAV--YPVSAVQVEYSPFSLEIERPEIGVMKA 196 Query: 342 CQSAGVHLSAYSPLG---------SP-----------GTTWMNGNVLKEPIIISISEKLG 461 C+ + + Y+PLG SP + N K +++ EK+ Sbjct: 197 CRENNITIVCYAPLGRGFLTGAYKSPDDFPEGDFRRKAPRYQKENFYKNLELVTKIEKIA 256 Query: 462 K----TPAQVALRWNIQTGHSVLP 521 TP Q++L W + G +LP Sbjct: 257 TANNITPGQLSLAWLLAQGDDILP 280
>A115_TOBAC (P40691) Auxin-induced protein PCNT115| Length = 307 Score = 35.8 bits (81), Expect = 0.076 Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 29/149 (19%) Frame = +3 Query: 162 IPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQ---QTKL 332 I T G ++KL + GK + IG+S S+ + AV P Q+E W + ++ Sbjct: 144 IEITVGELKKLVEEGKLKYIGLSEASASTIRRAHAVH--PITAVQLEWS-LWSRDVEEEI 200 Query: 333 HNFCQSAGVHLSAYSPLG----SPGTTWM----------------------NGNVLKEPI 434 C+ G+ + AYSPLG S G + N N+ + Sbjct: 201 IPTCRELGIGIVAYSPLGRGFLSSGPKLLEDMSNEDYRKYLPRFQAENLENNKNLYER-- 258 Query: 435 IISISEKLGKTPAQVALRWNIQTGHSVLP 521 I ++ + G TP+Q+AL W G+ V P Sbjct: 259 ICEMAVRKGCTPSQLALAWVHHQGNDVCP 287
>KCAB2_RAT (P62483) Voltage-gated potassium channel beta-2 subunit (K(+)| channel beta-2 subunit) (Kv-beta-2) Length = 367 Score = 35.0 bits (79), Expect = 0.13 Identities = 36/139 (25%), Positives = 57/139 (41%), Gaps = 35/139 (25%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ---TKLHN 338 AM + + G A G S +SS ++ + +VAR +PP +Q E H ++ +L Sbjct: 172 AMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPE 231 Query: 339 FCQSAGVHLSAYSPL-----------GSP--------GTTWMNGNVLKEP---------I 434 GV +SPL G P G W+ +L E Sbjct: 232 LFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE 291 Query: 435 IISISEKLGKTPAQVALRW 491 + +I+E+LG T Q+A+ W Sbjct: 292 LQAIAERLGCTLPQLAIAW 310
>KCAB2_MOUSE (P62482) Voltage-gated potassium channel beta-2 subunit (K(+)| channel beta-2 subunit) (Kv-beta-2) (Neuroimmune protein F5) Length = 367 Score = 35.0 bits (79), Expect = 0.13 Identities = 36/139 (25%), Positives = 57/139 (41%), Gaps = 35/139 (25%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ---TKLHN 338 AM + + G A G S +SS ++ + +VAR +PP +Q E H ++ +L Sbjct: 172 AMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPE 231 Query: 339 FCQSAGVHLSAYSPL-----------GSP--------GTTWMNGNVLKEP---------I 434 GV +SPL G P G W+ +L E Sbjct: 232 LFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE 291 Query: 435 IISISEKLGKTPAQVALRW 491 + +I+E+LG T Q+A+ W Sbjct: 292 LQAIAERLGCTLPQLAIAW 310
>KCAB2_BOVIN (Q27955) Voltage-gated potassium channel beta-2 subunit (K(+)| channel beta-2 subunit) (Kv-beta-2) Length = 367 Score = 35.0 bits (79), Expect = 0.13 Identities = 36/139 (25%), Positives = 57/139 (41%), Gaps = 35/139 (25%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ---TKLHN 338 AM + + G A G S +SS ++ + +VAR +PP +Q E H ++ +L Sbjct: 172 AMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPE 231 Query: 339 FCQSAGVHLSAYSPL-----------GSP--------GTTWMNGNVLKEP---------I 434 GV +SPL G P G W+ +L E Sbjct: 232 LFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE 291 Query: 435 IISISEKLGKTPAQVALRW 491 + +I+E+LG T Q+A+ W Sbjct: 292 LQAIAERLGCTLPQLAIAW 310
>YDBC_ECOLI (P25906) Putative oxidoreductase ydbC (EC 1.-.-.-)| Length = 286 Score = 34.7 bits (78), Expect = 0.17 Identities = 30/136 (22%), Positives = 56/136 (41%) Frame = +3 Query: 111 RVKKGTNNNPENFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAV 290 RV G + P I A+ + ++ G + IG+SN + ++ + +A + Sbjct: 126 RVMMGDGHGPAE---GSIEASLTVLAEMQQQGLVKHIGLSNVTPTQVAEARKIAEIVCVQ 182 Query: 291 DQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKLGKTP 470 ++ + G+ + PLG G T + + L + ++ LG TP Sbjct: 183 NEYNIAHRADDAMIDALAHD-GIAYVPFFPLG--GFTPLQSSTLSD-----VAASLGATP 234 Query: 471 AQVALRWNIQTGHSVL 518 QVAL W +Q ++L Sbjct: 235 MQVALAWLLQRSPNIL 250
>YDHF_ECOLI (P76187) Oxidoreductase ydhF (EC 1.-.-.-)| Length = 298 Score = 34.3 bits (77), Expect = 0.22 Identities = 34/120 (28%), Positives = 50/120 (41%), Gaps = 6/120 (5%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLH---NFCQS 350 A + LH +GK R GVSNF+ + L + A +QVE P Q L + Q Sbjct: 142 AFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQ 201 Query: 351 AGVHLSAYSPLGSPGTTWMNGNV---LKEPIIISISEKLGKTPAQVALRWNIQTGHSVLP 521 V A+S LG G N + L++ + + E + QV W ++ LP Sbjct: 202 LRVRPMAWSCLG--GGRLFNDDYFQPLRDELAVVAEELNAGSIEQVVYAWVLRLPSQPLP 259
>KCAB2_XENLA (Q9PTM5) Voltage-gated potassium channel beta-2 subunit (K(+)| channel beta-2 subunit) (Kv-beta-2) Length = 367 Score = 34.3 bits (77), Expect = 0.22 Identities = 36/139 (25%), Positives = 56/139 (40%), Gaps = 35/139 (25%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ---TKLHN 338 AM + + G A G S +SS ++ + +VAR +PP +Q E H ++ +L Sbjct: 172 AMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPE 231 Query: 339 FCQSAGVHLSAYSPL-----------GSP--------GTTWMNGNVLKEP---------I 434 GV +SPL G P G W+ +L E Sbjct: 232 LFHKIGVGAMTWSPLACGIVSGKYDGGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE 291 Query: 435 IISISEKLGKTPAQVALRW 491 +I+E+LG T Q+A+ W Sbjct: 292 FQAIAERLGCTLPQLAIAW 310
>KCAB2_HUMAN (Q13303) Voltage-gated potassium channel beta-2 subunit (K(+)| channel beta-2 subunit) (Kv-beta-2) (HKvbeta2) Length = 367 Score = 33.9 bits (76), Expect = 0.29 Identities = 36/139 (25%), Positives = 56/139 (40%), Gaps = 35/139 (25%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ---TKLHN 338 AM + + G A G S +SS ++ + +VAR PP +Q E H ++ +L Sbjct: 172 AMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPE 231 Query: 339 FCQSAGVHLSAYSPL-----------GSP--------GTTWMNGNVLKEP---------I 434 GV +SPL G P G W+ +L E Sbjct: 232 LFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE 291 Query: 435 IISISEKLGKTPAQVALRW 491 + +I+E+LG T Q+A+ W Sbjct: 292 LQAIAERLGCTLPQLAIAW 310
>YAJO_ECOLI (P77735) Hypothetical oxidoreductase yajO (EC 1.-.-.-)| Length = 324 Score = 33.1 bits (74), Expect = 0.50 Identities = 37/144 (25%), Positives = 58/144 (40%), Gaps = 28/144 (19%) Frame = +3 Query: 144 NFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCW-- 317 ++ TP I T A+ + AGKAR IG S+ + + L + + V + Sbjct: 130 DYNTP-IEETLEALNDVVKAGKARYIGASSMHASQFAQALELQKQHGWAQFVSMQDHYNL 188 Query: 318 ----QQTKLHNFCQSAGVHLSAYSPLGSPGTT--W-----------MNGNVLKEPI---- 434 ++ ++ C GV + +SPL T W + N+ KE Sbjct: 189 IYREEEREMLPLCYQEGVAVIPWSPLARGRLTRPWGETTARLVSDEVGKNLYKESDENDA 248 Query: 435 -----IISISEKLGKTPAQVALRW 491 + +SE+LG T AQVAL W Sbjct: 249 QIAERLTGVSEELGATRAQVALAW 272
>IN22_MAIZE (P49249) IN2-2 protein| Length = 306 Score = 32.3 bits (72), Expect = 0.85 Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 3/78 (3%) Frame = +3 Query: 162 IPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNF 341 I T G ++KL + GK + IG+S S+ + AV P Q+E W + + Sbjct: 139 IEVTIGELKKLVEEGKIKYIGLSEASASTIRRAHAVH--PITAVQLEWS-LWSRDAEEDI 195 Query: 342 ---CQSAGVHLSAYSPLG 386 C+ G+ + AYSPLG Sbjct: 196 IPTCRELGIGIVAYSPLG 213
>AFR_PIG (P82125) 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) (AF| reductase) (Fragments) Length = 206 Score = 31.2 bits (69), Expect = 1.9 Identities = 18/59 (30%), Positives = 33/59 (55%) Frame = +3 Query: 282 PAVDQVECHPCWQQTKLHNFCQSAGVHLSAYSPLGSPGTTWMNGNVLKEPIIISISEKL 458 P +Q+E HP T+ +F QS V ++AY PLG +L++P+I + ++++ Sbjct: 109 PVTNQIESHP--YLTQKISFXQSRNVSVTAYRPLGGSSE---GVPLLEDPVIQTXAKRI 162
>ARK72_HUMAN (O43488) Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-)| (AFB1-AR 1) (Aldoketoreductase 7) Length = 359 Score = 30.8 bits (68), Expect = 2.5 Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 6/80 (7%) Frame = +3 Query: 162 IPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ-- 323 + T A ++LH GK +G+SN++S ++ ++ + + + P V Q + +Q Sbjct: 149 VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVE 208 Query: 324 TKLHNFCQSAGVHLSAYSPL 383 T+L + G+ AY+PL Sbjct: 209 TELFPCLRHFGLRFYAYNPL 228
>ETR1_BRAOL (O49230) Ethylene receptor (EC 2.7.13.3)| Length = 735 Score = 30.0 bits (66), Expect = 4.2 Identities = 17/55 (30%), Positives = 28/55 (50%) Frame = -3 Query: 305 AFHLINSWRYTSYGKQVTQLL**KVTHTNRASFASIM*LLHCPPSSRYVRCNEVF 141 A HLIN W +T++ + V ++ T S A+ + L+H P V+ E+F Sbjct: 67 ATHLINLWTFTTHSRTVALVMTTAKVLTAVVSCATALMLVHIIPDLLSVKTRELF 121
>ETR1_ARATH (P49333) Ethylene receptor (EC 2.7.13.3)| Length = 738 Score = 30.0 bits (66), Expect = 4.2 Identities = 17/55 (30%), Positives = 28/55 (50%) Frame = -3 Query: 305 AFHLINSWRYTSYGKQVTQLL**KVTHTNRASFASIM*LLHCPPSSRYVRCNEVF 141 A HLIN W +T++ + V ++ T S A+ + L+H P V+ E+F Sbjct: 67 ATHLINLWTFTTHSRTVALVMTTAKVLTAVVSCATALMLVHIIPDLLSVKTRELF 121
>IOLS_BACSU (P46336) Protein iolS (EC 1.1.1.-) (Vegetative protein 147)| (VEG147) (AKR11A) Length = 310 Score = 29.6 bits (65), Expect = 5.5 Identities = 13/24 (54%), Positives = 19/24 (79%) Frame = +3 Query: 180 AMEKLHDAGKARAIGVSNFSSKKL 251 A+ ++ AGK R+IGVSNFS ++L Sbjct: 139 ALNEMKKAGKIRSIGVSNFSLEQL 162
>ETR1_PASED (Q9ZWL6) Ethylene receptor (EC 2.7.13.3) (PE-ETR1)| Length = 738 Score = 29.6 bits (65), Expect = 5.5 Identities = 17/55 (30%), Positives = 27/55 (49%) Frame = -3 Query: 305 AFHLINSWRYTSYGKQVTQLL**KVTHTNRASFASIM*LLHCPPSSRYVRCNEVF 141 A HLIN W +T + + V ++ T S A+ + L+H P V+ E+F Sbjct: 67 ATHLINLWTFTMHSRTVATVMTIAKVLTAVVSCATALMLVHIIPDLLSVKTRELF 121
>ARK74_HUMAN (Q8NHP1) Aflatoxin B1 aldehyde reductase member 4 (EC 1.-.-.-)| (Fragment) Length = 319 Score = 29.6 bits (65), Expect = 5.5 Identities = 20/80 (25%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Frame = +3 Query: 162 IPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ-- 323 + T A +LH GK +G+SN+++ ++ ++ + + + P V Q +Q Sbjct: 109 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVE 168 Query: 324 TKLHNFCQSAGVHLSAYSPL 383 T+L + + G+ AY+PL Sbjct: 169 TELFPYLRHFGLRFYAYNPL 188
>CLUS_HUMAN (P10909) Clusterin precursor (Complement-associated protein| SP-40,40) (Complement cytolysis inhibitor) (CLI) (NA1/NA2) (Apolipoprotein J) (Apo-J) (Testosterone-repressed prostate message 2) (TRPM-2) [Contains: Clusterin beta chain (ApoJalpha) Length = 449 Score = 29.6 bits (65), Expect = 5.5 Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 9/87 (10%) Frame = +3 Query: 183 MEKLHDAGKAR--AIGVSNFSSKKLGDLLAVARVPPAVDQVECHPCWQQTKLHNF---CQ 347 + L +A K + A+ + S KL +L V EC PC +QT + + C+ Sbjct: 71 LSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCR 130 Query: 348 S----AGVHLSAYSPLGSPGTTWMNGN 416 S G L + SP WMNG+ Sbjct: 131 SGSGLVGRQLEEFLNQSSPFYFWMNGD 157
>ETR1_CUCSA (Q9SSY6) Ethylene receptor (EC 2.7.13.3) (CS-ETR1)| Length = 740 Score = 29.3 bits (64), Expect = 7.2 Identities = 17/55 (30%), Positives = 27/55 (49%) Frame = -3 Query: 305 AFHLINSWRYTSYGKQVTQLL**KVTHTNRASFASIM*LLHCPPSSRYVRCNEVF 141 A HLIN W +T + + V ++ T S A+ + L+H P V+ E+F Sbjct: 67 ATHLINLWTFTMHSRTVAVVMTTAKVLTAVVSCATALMLVHIIPDLLSVKTRELF 121
>ETR1_CUCMR (O82436) Ethylene receptor (EC 2.7.13.3) (MEETR1) (Cm-ETR1)| Length = 740 Score = 29.3 bits (64), Expect = 7.2 Identities = 17/55 (30%), Positives = 27/55 (49%) Frame = -3 Query: 305 AFHLINSWRYTSYGKQVTQLL**KVTHTNRASFASIM*LLHCPPSSRYVRCNEVF 141 A HLIN W +T + + V ++ T S A+ + L+H P V+ E+F Sbjct: 67 ATHLINLWTFTMHSRTVAVVMTTAKVLTAVVSCATALMLVHIIPDLLSVKTRELF 121
>ARK72_RAT (Q8CG45) Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-)| (rAFAR2) Length = 367 Score = 29.3 bits (64), Expect = 7.2 Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 6/80 (7%) Frame = +3 Query: 162 IPATWGAMEKLHDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPCWQQ-- 323 I T A ++LH GK +G+SN++S ++ ++ + + + P V Q + +Q Sbjct: 157 IVETLQACQQLHQEGKFVELGLSNYASWEVAEIYTLCKSNGWILPTVYQGMYNATTRQVE 216 Query: 324 TKLHNFCQSAGVHLSAYSPL 383 T+L + G+ AY+PL Sbjct: 217 TELLPCLRYFGLRFYAYNPL 236
>ECTA_HALEL (O52249) L-2,4-diaminobutyric acid acetyltransferase (EC 2.3.1.-)| (DABA acetyltransferase) Length = 192 Score = 28.9 bits (63), Expect = 9.3 Identities = 14/38 (36%), Positives = 20/38 (52%) Frame = +3 Query: 141 ENFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLG 254 E +TPD A+WG +L D +A FS+ +LG Sbjct: 136 ETTITPDNQASWGLFRRLADRWQAPLNSREYFSTDQLG 173
>ECTA_CHRSL (Q9ZEU8) L-2,4-diaminobutyric acid acetyltransferase (EC 2.3.1.-)| (DABA acetyltransferase) Length = 192 Score = 28.9 bits (63), Expect = 9.3 Identities = 14/38 (36%), Positives = 21/38 (55%) Frame = +3 Query: 141 ENFVTPDIPATWGAMEKLHDAGKARAIGVSNFSSKKLG 254 E +TPD A+WG ++L D +A FS+ +LG Sbjct: 136 ETTITPDNEASWGLFKRLADRWQAPLNSREYFSTGQLG 173 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 69,735,584 Number of Sequences: 219361 Number of extensions: 1250709 Number of successful extensions: 3481 Number of sequences better than 10.0: 108 Number of HSP's better than 10.0 without gapping: 3291 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 3356 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4142954952 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
