>YIL0_YEAST (P40481) Hypothetical 42.5 kDa protein in COX5B-PFK26 intergenic|
           region
          Length = 377

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/96 (40%), Positives = 54/96 (56%), Gaps = 9/96 (9%)
 Frame = +3

Query: 234 VFGVKNSDLVPGKYEGGLKLWEGSLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIY 413
           + G  + DL    YEGGLK WE S DLV  L+ ++  DR+  +   ++E+GCG  LP  +
Sbjct: 115 LLGDTSEDLRKNIYEGGLKSWECSYDLVDLLSENV--DRISNDIDAVVEIGCGTALPSEF 172

Query: 414 ---AAL------KGAGLVHFQDFNAEVLRCLTIPNV 494
              +AL      KG   V   D+NA VLR +TIPN+
Sbjct: 173 LFRSALLRNDRSKGLKFV-LTDYNASVLRLVTIPNL 207

>NNT1_CRYNE (Q5KDV2) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 299

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
 Frame = +3

Query: 279 GGLKLWEGSL-DLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF 455
           G   LW   L +  +TL++ + +   + + +H+LELG G GLP I   L G+  V   D+
Sbjct: 64  GSHPLWGHHLWNTARTLSTYLLETPQITQSRHVLELGAGAGLPSIVCVLAGSSKVIVTDY 123

Query: 456 NAEVLRCLTIPNVKANLFKESSQ 524
           + E L      NV  NL  E  +
Sbjct: 124 SDEGLLDNLRFNVDVNLEGEEKE 146

>NNT1_GIBZE (Q4I2X5) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 594

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 21/64 (32%), Positives = 36/64 (56%), Gaps = 1/64 (1%)
 Frame = +3

Query: 291 LWEGSLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF-NAEV 467
           LW G+    K +    ++D   ++GK +LELG   GLP + AA+ GA  V   D+ + ++
Sbjct: 54  LWNGA----KMIADFFEEDLSRVKGKTVLELGAAAGLPSLVAAILGAHKVVVTDYPDPDI 109

Query: 468 LRCL 479
           +R +
Sbjct: 110 IRIM 113

>NNT1_ASPFU (Q4WYS7) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 259

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 16/34 (47%), Positives = 23/34 (67%)
 Frame = +3

Query: 354 LIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF 455
           L+EGK +LE+G   G+P I +A+KGA  V   D+
Sbjct: 73  LVEGKDVLEVGAAAGVPSIVSAVKGARTVVMTDY 106

>NNT1_YEAST (Q05874) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 261

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 25/75 (33%), Positives = 36/75 (48%)
 Frame = +3

Query: 282 GLKLWEGSLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNA 461
           G  LW   +     L+S  +    LI+GK +LELG    LP +  AL GA +V   D+  
Sbjct: 60  GHLLWNAGIYTANHLDSHPE----LIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPD 115

Query: 462 EVLRCLTIPNVKANL 506
             L      N+K+N+
Sbjct: 116 PDLMQNIDYNIKSNV 130

>YLW9_CAEEL (P34412) Hypothetical protein F22B7.9|
          Length = 243

 Score = 35.4 bits (80), Expect = 0.11
 Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
 Frame = +3

Query: 294 WEGSLDLVKTLNS--DIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEV 467
           WEG   +  T+++  +++ +    +GK +LE+G   GLP +YA   GA  +     +   
Sbjct: 59  WEGVNTICHTIDNIVNVEMETDFFDGKSVLEIGFVTGLPSVYAFENGAEEIAMHTMDKTS 118

Query: 468 LRCLTIPNVKAN 503
           L     P +K N
Sbjct: 119 LELYCRPTLKRN 130

>NNT1_SCHPO (Q9UT28) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 255

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 26/91 (28%), Positives = 43/91 (47%)
 Frame = +3

Query: 291 LWEGSLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEVL 470
           LW   ++L   ++ +       +  K +LELG G GLP I +A  GA  V   D+    L
Sbjct: 57  LWNSGIELANYIDKNPDT----VRAKKVLELGAGAGLPSIVSAFDGAKFVVSTDYPDPAL 112

Query: 471 RCLTIPNVKANLFKESSQGTFTSRSVGFYAG 563
               I N++ N+ K+ ++      +VG+  G
Sbjct: 113 ----IDNLEHNV-KQYAEIASKISAVGYLWG 138

>NNT1_YARLI (Q6CHE9) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 273

 Score = 33.5 bits (75), Expect = 0.43
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
 Frame = +3

Query: 291 LWEGSLDLVKTLNSDIKDD--RLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF 455
           LW   L     + SD  D+  + L+EGK ++E G G GLP +     GA  V   D+
Sbjct: 59  LWGHLLWNAGKVTSDYLDEHSKELVEGKKVIEFGAGAGLPSLLCHAVGAKQVVITDY 115

>PRMA_WOLSU (P60095) Ribosomal protein L11 methyltransferase (EC 2.1.1.-) (L11|
           Mtase)
          Length = 275

 Score = 33.1 bits (74), Expect = 0.56
 Identities = 14/27 (51%), Positives = 20/27 (74%)
 Frame = +3

Query: 351 LLIEGKHILELGCGHGLPGIYAALKGA 431
           L +EGK +L++GCG G+  I +A KGA
Sbjct: 140 LELEGKRVLDVGCGSGILAIASAKKGA 166

>UBIG_PSEPK (Q88M10) 3-demethylubiquinone-9 3-methyltransferase (EC 2.1.1.64)|
           (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase)
           (DHHB methyltransferase)
          Length = 232

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 13/30 (43%), Positives = 21/30 (70%)
 Frame = +3

Query: 342 DDRLLIEGKHILELGCGHGLPGIYAALKGA 431
           D+R+ + GK +L++GCG G+     AL+GA
Sbjct: 41  DERVSLAGKKVLDVGCGGGILSEAMALRGA 70

>UBIG_COXBU (Q820B5) 3-demethylubiquinone-9 3-methyltransferase (EC 2.1.1.64)|
           (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase)
           (DHHB methyltransferase)
          Length = 234

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 14/42 (33%), Positives = 24/42 (57%)
 Frame = +3

Query: 306 LDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGA 431
           L L+  +     + ++ ++GKH+L++GCG GL     A  GA
Sbjct: 33  LHLINPVRLKYIEQQITLKGKHVLDVGCGGGLLSEALAKHGA 74

>NNT1_EMENI (Q5BAD0) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 262

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 14/34 (41%), Positives = 20/34 (58%)
 Frame = +3

Query: 354 LIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF 455
           LI GK +LE+G   G+P I +A+ GA      D+
Sbjct: 73  LIAGKDVLEIGAAAGVPSIVSAIMGARTTVMTDY 106

>TEHB_HAEIN (P45134) Tellurite resistance protein tehB homolog|
          Length = 286

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/61 (29%), Positives = 29/61 (47%)
 Frame = +3

Query: 324 LNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEVLRCLTIPNVKAN 503
           ++ D+ D   +I    +L+LGCG G   +Y +L G  +  + D N   +  L     K N
Sbjct: 108 IHGDVVDAAKIISPCKVLDLGCGQGRNSLYLSLLGYDVTSW-DHNENSIAFLNETKEKEN 166

Query: 504 L 506
           L
Sbjct: 167 L 167

>Y1172_PYRFU (Q8U1N4) Hypothetical RNA methyltransferase PF1172 (EC 2.1.1.-)|
          Length = 411

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
 Frame = +3

Query: 303 SLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEVLRCLT 482
           +++LVKT+          +EG+ ++++  G G  G+Y A KG  +V F D NA  +    
Sbjct: 260 AVNLVKTVEK-------FVEGEKVVDMYSGVGTFGVYLAKKGMKVVGF-DSNAFAIEMAN 311

Query: 483 ----IPNVKANLFKESSQ 524
               I NV+A  F  S +
Sbjct: 312 KNAEINNVEAEFFVASDR 329

>UBIG_CHRVO (Q7NZ91) 3-demethylubiquinone-9 3-methyltransferase (EC 2.1.1.64)|
           (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase)
           (DHHB methyltransferase)
          Length = 232

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 15/39 (38%), Positives = 21/39 (53%)
 Frame = +3

Query: 315 VKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGA 431
           +  L  D  D    I GK +L++GCG G+     AL+GA
Sbjct: 32  INPLRLDFIDRHASIAGKKVLDVGCGGGILAESMALRGA 70

>UBIG_PSESM (Q885T9) 3-demethylubiquinone-9 3-methyltransferase (EC 2.1.1.64)|
           (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase)
           (DHHB methyltransferase)
          Length = 232

 Score = 30.8 bits (68), Expect = 2.8
 Identities = 13/30 (43%), Positives = 20/30 (66%)
 Frame = +3

Query: 342 DDRLLIEGKHILELGCGHGLPGIYAALKGA 431
           D+R  + GK +L++GCG G+     AL+GA
Sbjct: 41  DERANLAGKKVLDVGCGGGILSEAMALRGA 70

>GIDB_LEGPL (Q5WSS3) Methyltransferase gidB (EC 2.1.-.-) (Glucose-inhibited|
           division protein B)
          Length = 208

 Score = 30.4 bits (67), Expect = 3.6
 Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 8/55 (14%)
 Frame = +3

Query: 357 IEGKHILELGCGHGLPGIYAALKGAGLVHFQ--------DFNAEVLRCLTIPNVK 497
           I+G HI+++G G GLPGI  A+    L             F  EV R L I N++
Sbjct: 67  IKGNHIIDVGTGPGLPGIPLAIAKPDLQFVLLDSNGKKISFLNEVKRQLNIKNIE 121

>GIDB_LEGPA (Q5X0Z7) Methyltransferase gidB (EC 2.1.-.-) (Glucose-inhibited|
           division protein B)
          Length = 208

 Score = 30.4 bits (67), Expect = 3.6
 Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 8/55 (14%)
 Frame = +3

Query: 357 IEGKHILELGCGHGLPGIYAALKGAGLVHFQ--------DFNAEVLRCLTIPNVK 497
           I+G HI+++G G GLPGI  A+    L             F  EV R L I N++
Sbjct: 67  IKGNHIIDVGTGPGLPGIPLAIAKPDLQFVLLDSNGKKISFLNEVKRQLNIKNIE 121

>MMT1_WOLBI (Q9SWR3) Methionine S-methyltransferase (EC 2.1.1.12) (AdoMet:Met|
           S-methyltransferase)
          Length = 1088

 Score = 30.4 bits (67), Expect = 3.6
 Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
 Frame = +3

Query: 354 LIEGKHILELGCGHGLPGIYAALKGAGL-VHFQDFNAEVLRCLTIPNVKANLFKESSQGT 530
           + + K + ELGCG+G   I  A K   L V+  D N   ++   I N+  N F E  Q  
Sbjct: 121 IFKDKTVAELGCGNGWISIAIAEKWLPLKVYGLDINPRAVKISWI-NLYLNAFDEDGQPV 179

Query: 531 FTSRS 545
           + S S
Sbjct: 180 YDSES 184

>FLGH_HELPJ (Q9ZMB3) Flagellar L-ring protein precursor (Basal body L-ring|
           protein)
          Length = 237

 Score = 30.4 bits (67), Expect = 3.6
 Identities = 16/46 (34%), Positives = 27/46 (58%), Gaps = 6/46 (13%)
 Frame = -2

Query: 310 SNDPSHSFNPPSYFPGTKSEFFTPKTSEVLTL------PL*IDRES 191
           +N+P+  FNPP+Y   T S+ F P+ +++ +L      PL  DR +
Sbjct: 21  ANEPNIDFNPPNYVEETPSKEFIPELNKLGSLFGQGERPLFADRRA 66

>NNT1_NEUCR (Q7S634) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 282

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 16/55 (29%), Positives = 29/55 (52%)
 Frame = +3

Query: 291 LWEGSLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF 455
           LW G++ + +      ++    ++ + +LE+G   GLP + AA+ GA  V   DF
Sbjct: 66  LWNGAVIISQYFEEHPEE----VKDRTVLEIGAAAGLPSLVAAVLGAKKVVVTDF 116

>GIDB_LEGPH (Q5ZRJ1) Methyltransferase gidB (EC 2.1.-.-) (Glucose-inhibited|
           division protein B)
          Length = 208

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 12/22 (54%), Positives = 17/22 (77%)
 Frame = +3

Query: 357 IEGKHILELGCGHGLPGIYAAL 422
           I+G HI+++G G GLPGI  A+
Sbjct: 67  IKGNHIIDVGTGPGLPGIPLAI 88

>COQ3_SCHPO (O74421) Hexaprenyldihydroxybenzoate methyltransferase,|
           mitochondrial precursor (EC 2.1.1.114)
           (Dihydroxyhexaprenylbenzoate methyltransferase)
           (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase)
           (DHHB methyltransferase) (DHHB-MT) (DHHB-MTas
          Length = 271

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
 Frame = +3

Query: 294 WEGSLDLVKTLNSDIKD-------DRLLIEGKHILELGCGHGLPGIYAALKGAGL 437
           W+G   L+  +NS   D       +R    GK IL++GCG G+     A  GA +
Sbjct: 48  WDGGSRLLHLMNSTRLDFMTEVFRERNCFSGKKILDIGCGGGILSESMARLGASV 102

>NNT1_CANAL (Q5A013) Putative nicotinamide N-methyltransferase (EC 2.1.1.1)|
          Length = 262

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 19/58 (32%), Positives = 26/58 (44%)
 Frame = +3

Query: 282 GLKLWEGSLDLVKTLNSDIKDDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDF 455
           G  LW   +     L+   K    L++GK ILELG    LP +  +L  A  V   D+
Sbjct: 55  GHLLWNAGIYTADYLD---KHSDTLVQGKKILELGAASALPSLVCSLNHAKEVIVTDY 109

>FLGH_HELPY (O25092) Flagellar L-ring protein precursor (Basal body L-ring|
           protein)
          Length = 237

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 6/46 (13%)
 Frame = -2

Query: 310 SNDPSHSFNPPSYFPGTKSEFFTPKTSEVLTL------PL*IDRES 191
           +N+P   FNPP+Y   T S+ F P+ +++ +L      PL  DR +
Sbjct: 21  ANEPKIDFNPPNYVEETPSKEFIPELNKLGSLFGQGERPLFADRRA 66

>PRMA_PHOLL (P60092) Ribosomal protein L11 methyltransferase (EC 2.1.1.-) (L11|
           Mtase)
          Length = 296

 Score = 29.6 bits (65), Expect = 6.1
 Identities = 13/29 (44%), Positives = 18/29 (62%)
 Frame = +3

Query: 345 DRLLIEGKHILELGCGHGLPGIYAALKGA 431
           D L +EGK +++ GCG G+  I A   GA
Sbjct: 153 DSLNLEGKTVIDFGCGSGILAIAALKLGA 181

>Y928_METJA (Q58338) Hypothetical protein MJ0928 (M.MjaHemkP)|
          Length = 197

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 18/49 (36%), Positives = 25/49 (51%)
 Frame = +3

Query: 357 IEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEVLRCLTIPNVKAN 503
           ++ K +LE+G G GL  I  A KGA  +   D N   ++ L   N K N
Sbjct: 33  VKNKDVLEIGVGTGLISIACAKKGAKKIVGVDINPYAVK-LAKENAKLN 80

>GIDB_PASMU (P57946) Methyltransferase gidB (EC 2.1.-.-) (Glucose-inhibited|
           division protein B)
          Length = 210

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 10/22 (45%), Positives = 17/22 (77%)
 Frame = +3

Query: 357 IEGKHILELGCGHGLPGIYAAL 422
           ++GKH +++G G GLPG+  A+
Sbjct: 71  LQGKHFIDVGTGPGLPGLPLAI 92

>PRMA_SYNY3 (P73820) Ribosomal protein L11 methyltransferase (EC 2.1.1.-) (L11|
           Mtase)
          Length = 300

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 4/97 (4%)
 Frame = +3

Query: 174 EPVVVDDSLSIYKGRVNTSDVFGVKNSDLVPGKYEGGLKLWEGSLDL----VKTLNSDIK 341
           +P  V D   IY   ++  +     NSD +  + + G+    G+       +++L   ++
Sbjct: 99  QPTPVGDRFIIYPAWIDPPE-----NSDRLILRLDPGVAFGTGTHATTQLCLESLEMRVE 153

Query: 342 DDRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQD 452
            D+  +    + +LGCG G+ GI A L GA  V+  D
Sbjct: 154 PDKHQV----LADLGCGSGILGIGAVLLGAAKVYGVD 186

>PRMA_NEIMB (Q9JXW2) Ribosomal protein L11 methyltransferase (EC 2.1.1.-) (L11|
           Mtase)
          Length = 295

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 15/43 (34%), Positives = 22/43 (51%)
 Frame = +3

Query: 345 DRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEVLR 473
           D  L  G+ +L+ GCG G+  I A   GAG     D + + +R
Sbjct: 158 DTQLKNGESVLDYGCGSGILTIAALKLGAGFAVGVDIDEQAVR 200

>PRMA_NEIMA (Q9JW08) Ribosomal protein L11 methyltransferase (EC 2.1.1.-) (L11|
           Mtase)
          Length = 295

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 15/43 (34%), Positives = 22/43 (51%)
 Frame = +3

Query: 345 DRLLIEGKHILELGCGHGLPGIYAALKGAGLVHFQDFNAEVLR 473
           D  L  G+ +L+ GCG G+  I A   GAG     D + + +R
Sbjct: 158 DTQLKNGESVLDYGCGSGILTIAALKLGAGFAVGVDIDEQAVR 200

>PRMA_ERWCT (Q6DAJ5) Ribosomal protein L11 methyltransferase (EC 2.1.1.-) (L11|
           Mtase)
          Length = 295

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 14/29 (48%), Positives = 18/29 (62%)
 Frame = +3

Query: 345 DRLLIEGKHILELGCGHGLPGIYAALKGA 431
           D L +EGK I++ GCG G+  I A   GA
Sbjct: 153 DGLDLEGKTIIDFGCGSGILAIAALKLGA 181

>CUBN_MOUSE (Q9JLB4) Cubilin precursor (Intrinsic factor-cobalamin receptor)|
          Length = 3623

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 25/75 (33%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
 Frame = +3

Query: 222  NTSDVFGVKNSDLVPGKYEGGLKLWEGSLDLVKTLNSDIKDDRLLIEGK---HILELGCG 392
            NT  V+ + +S   PG +   L+L   S  L  +LN + KD   + EG    H++   CG
Sbjct: 1761 NTECVWNIASS---PGNH---LQLSFLSFQLENSLNCN-KDFVEIREGNATGHLMGRYCG 1813

Query: 393  HGLPGIYAALKGAGL 437
            + LPG Y++++G  L
Sbjct: 1814 NSLPGNYSSIEGHNL 1828


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,636,713
Number of Sequences: 219361
Number of extensions: 1399084
Number of successful extensions: 3653
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 3552
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3649
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 4643056080
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)