ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags7e10 |
|---|---|
| Clone Library Name | barley_pub |
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 317 bits (813), Expect = 1e-86 Identities = 156/167 (93%), Positives = 159/167 (95%) Frame = +2 Query: 23 NLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI 202 NLKK+LNW RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI Sbjct: 598 NLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI 657 Query: 203 MGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 +GP DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQ EE Sbjct: 658 LGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQFEE 717 Query: 383 GNIVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVRMR 523 GNIVEWA PLIKAGDI ILDP LSPPSD EALKKIA+VACKCVRMR Sbjct: 718 GNIVEWAVPLIKAGDIFAILDPVLSPPSDLEALKKIASVACKCVRMR 764
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 150 bits (379), Expect = 2e-36 Identities = 78/164 (47%), Positives = 111/164 (67%), Gaps = 2/164 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 +K L+W R++IA+ AARG+ YLH + VIHRD+KSSNIL+D+ A+VADFG S Sbjct: 688 RKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYA 747 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE--E 382 P + + +S GT GYLDPEYY+ L+ KSDV+SFGVVLLEI+SGR+ ++++ E Sbjct: 748 PQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRIE 807 Query: 383 GNIVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 ++VEWA P I+A + I+DP + EAL ++ VA +C+ Sbjct: 808 WSLVEWAKPYIRASKVDEIVDPGIKGGYHAEALWRVVEVALQCL 851
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 149 bits (377), Expect = 3e-36 Identities = 78/164 (47%), Positives = 110/164 (67%), Gaps = 2/164 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 +K L+W R++IA+ AARG+ YLH + VIHRD+KSSNIL+D A+VADFG S Sbjct: 687 RKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYA 746 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE--E 382 P + + +S GT GYLDPEYY+ L+ KSDV+SFGVVLLEI+SGR+ ++++ E Sbjct: 747 PQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRVE 806 Query: 383 GNIVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 ++VEWA P I+A + I+DP + EAL ++ VA +C+ Sbjct: 807 WSLVEWAKPYIRASKVDEIVDPGIKGGYHAEALWRVVEVALQCL 850
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 142 bits (357), Expect = 7e-34 Identities = 77/166 (46%), Positives = 103/166 (62%), Gaps = 3/166 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 K+ L+W R+ IA AA+G+E+LH A PPVI+RD KSSNIL+DE + +++DFGL+ +G Sbjct: 179 KEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLG 238 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG- 385 P + +S GT GY PEY LT KSDVYSFGVV LE+++GRKAID ++ G Sbjct: 239 PTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGE 298 Query: 386 -NIVEWAAPLIK-AGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 N+V WA PL + DP L AL + AVA C++ Sbjct: 299 QNLVAWARPLFNDRRKFIKLADPRLKGRFPTRALYQALAVASMCIQ 344
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 140 bits (354), Expect = 2e-33 Identities = 76/166 (45%), Positives = 104/166 (62%), Gaps = 3/166 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 KK L+W R+ IA AARG+EYLH PPVI+RD+K SNIL+ ED+ +++DFGL+ +G Sbjct: 196 KKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVG 255 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID--MQLEE 382 P T +S GT GY P+Y LT KSD+YSFGVVLLE+++GRKAID ++ Sbjct: 256 PSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKD 315 Query: 383 GNIVEWAAPLIK-AGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 N+V WA PL K + ++DP L L + A++ CV+ Sbjct: 316 QNLVGWARPLFKDRRNFPKMVDPLLQGQYPVRGLYQALAISAMCVQ 361
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 135 bits (340), Expect = 7e-32 Identities = 76/170 (44%), Positives = 106/170 (62%), Gaps = 3/170 (1%) Frame = +2 Query: 14 RXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFG 193 R + L+W RV +A+ AARG+ +LH A P VI+RD K+SNIL+D ++NA+++DFG Sbjct: 165 RRGTFYQPLSWNTRVRMALGAARGLAFLHN-AQPQVIYRDFKASNILLDSNYNAKLSDFG 223 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID-- 367 L+ GP+ + +S GT GY PEY +L+ KSDVYSFGVVLLE+LSGR+AID Sbjct: 224 LARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKN 283 Query: 368 MQLEEGNIVEWAAP-LIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 + E N+V+WA P L + ++DP L KIA +A C+ Sbjct: 284 QPVGEHNLVDWARPYLTNKRRLLRVMDPRLQGQYSLTRALKIAVLALDCI 333
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 134 bits (338), Expect = 1e-31 Identities = 68/159 (42%), Positives = 103/159 (64%), Gaps = 1/159 (0%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+W R+ I++ AA+G+EYLH PP++HRD+K +NIL++E A++ADFGLS V+ Sbjct: 666 LSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVE 725 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAI-DMQLEEGNIV 394 +S + AG++GYLDPEYY + KSDVYS GVVLLE+++G+ AI + E+ +I Sbjct: 726 GSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQPAIASSKTEKVHIS 785 Query: 395 EWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKC 511 + ++ GDI GI+D L D + K++ +A C Sbjct: 786 DHVRSILANGDIRGIVDQRLRERYDVGSAWKMSEIALAC 824
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 132 bits (333), Expect = 4e-31 Identities = 73/170 (42%), Positives = 107/170 (62%), Gaps = 3/170 (1%) Frame = +2 Query: 14 RXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFG 193 R + + L+WT R+ +A+ AA+G+ +LH A VI+RD K+SNIL+D ++NA+++DFG Sbjct: 166 RRGSYFQPLSWTLRLKVALGAAKGLAFLHN-AETSVIYRDFKTSNILLDSEYNAKLSDFG 224 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQ 373 L+ GP + +S GT GY PEY +LTTKSDVYS+GVVLLE+LSGR+A+D Sbjct: 225 LAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRRAVDKN 284 Query: 374 LEEG--NIVEWAAPLI-KAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 G +VEWA PL+ + ++D L E K+A +A +C+ Sbjct: 285 RPPGEQKLVEWARPLLANKRKLFRVIDNRLQDQYSMEEACKVATLALRCL 334
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 132 bits (333), Expect = 4e-31 Identities = 72/162 (44%), Positives = 104/162 (64%), Gaps = 3/162 (1%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+W R+ +A+ AA+G+ +LH VI+RD K+SNIL+D ++NA+++DFGL+ GP+ Sbjct: 173 LSWKLRLKVALGAAKGLAFLHSSETR-VIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIG 231 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG--NI 391 + +S GT GY PEY +LTTKSDVYSFGVVLLE+LSGR+A+D G N+ Sbjct: 232 DKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRRAVDKNRPSGERNL 291 Query: 392 VEWAAP-LIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 VEWA P L+ I ++D L E K+A ++ +C+ Sbjct: 292 VEWAKPYLVNKRKIFRVIDNRLQDQYSMEEACKVATLSLRCL 333
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 131 bits (329), Expect = 1e-30 Identities = 71/142 (50%), Positives = 96/142 (67%), Gaps = 3/142 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPV 214 LNW R IA+ AARG+ +LH P +IHRD+KSSN+L+DED ARV+DFG++ ++ + Sbjct: 956 LNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSAL 1015 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQL--EEGN 388 D+ +S L AGT GY+ PEYY+ T K DVYS+GV+LLE+LSG+K ID E+ N Sbjct: 1016 DTHLSVSTL-AGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDNN 1074 Query: 389 IVEWAAPLIKAGDISGILDPAL 454 +V WA L + + ILDP L Sbjct: 1075 LVGWAKQLYREKRGAEILDPEL 1096
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 129 bits (324), Expect = 5e-30 Identities = 73/163 (44%), Positives = 106/163 (65%), Gaps = 4/163 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPV 214 L+W+ R IA+ AARG+ +LH P +IHRD+KSSN+L+D+D ARV+DFG++ ++ + Sbjct: 954 LDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSAL 1013 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQL--EEGN 388 D+ +S L AGT GY+ PEYY+ T K DVYS+GV+LLE+LSG+K ID + E+ N Sbjct: 1014 DTHLSVSTL-AGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPEEFGEDNN 1072 Query: 389 IVEWAAPLIKAGDISGILDPAL-SPPSDPEALKKIAAVACKCV 514 +V WA L + + ILDP L + S L +A +C+ Sbjct: 1073 LVGWAKQLYREKRGAEILDPELVTDKSGDVELLHYLKIASQCL 1115
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 124 bits (312), Expect = 1e-28 Identities = 66/162 (40%), Positives = 100/162 (61%), Gaps = 3/162 (1%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPV 214 L W R+ IA AA+G+ YLH P ++HRDIKSSNIL+DE+ N+ +ADFGL+ +M P Sbjct: 829 LKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPY 888 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG--N 388 + T +S GTLGY+ PEY + T K DVYSFGVVLLE+L+ ++ +DM +G + Sbjct: 889 E--THVSTDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKRPVDMCKPKGCRD 946 Query: 389 IVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 ++ W + S + DP + + + + ++ +AC C+ Sbjct: 947 LISWVVKMKHESRASEVFDPLIYSKENDKEMFRVLEIACLCL 988
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 124 bits (312), Expect = 1e-28 Identities = 73/163 (44%), Positives = 105/163 (64%), Gaps = 6/163 (3%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGP 211 +LNW+ R IA+ +ARG+ +LH P +IHRD+KSSN+L+DE+ ARV+DFG++ +M Sbjct: 977 KLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA 1036 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDM-QLEEGN 388 +D+ +S L AGT GY+ PEYY+ +TK DVYS+GVVLLE+L+G++ D + N Sbjct: 1037 MDTHLSVSTL-AGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNN 1095 Query: 389 IVEWAAPLIKAGDISGILDPAL---SPPSDPEALKKI-AAVAC 505 +V W K IS + DP L P + E L+ + AVAC Sbjct: 1096 LVGWVKQHAKL-RISDVFDPELMKEDPALEIELLQHLKVAVAC 1137
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 124 bits (310), Expect = 2e-28 Identities = 63/154 (40%), Positives = 95/154 (61%), Gaps = 3/154 (1%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L W R+ IA+ AA G+ YLH PP++HRD+KSSNIL+D D+ A+VADFG++ +G + Sbjct: 788 LGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQM- 846 Query: 218 SGTPLSELP---AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGN 388 SG+ E AG+ GY+ PEY + KSD+YSFGVVLLE+++G++ D +L + + Sbjct: 847 SGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQPTDSELGDKD 906 Query: 389 IVEWAAPLIKAGDISGILDPALSPPSDPEALKKI 490 + +W + + ++DP L E K I Sbjct: 907 MAKWVCTALDKCGLEPVIDPKLDLKFKEEISKVI 940
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 123 bits (308), Expect = 4e-28 Identities = 68/163 (41%), Positives = 102/163 (62%), Gaps = 4/163 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPV 214 L+W++R+ IAV AARG+ +LH P +IHRDIK+SNIL+D D +VADFGL+ ++ Sbjct: 1012 LDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISAC 1071 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE---G 385 +S +S + AGT GY+ PEY + TTK DVYSFGV+LLE+++G++ +E G Sbjct: 1072 ES--HVSTVIAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEPTGPDFKESEGG 1129 Query: 386 NIVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 N+V WA I G ++DP L + + ++ +A C+ Sbjct: 1130 NLVGWAIQKINQGKAVDVIDPLLVSVALKNSQLRLLQIAMLCL 1172
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 121 bits (304), Expect = 1e-27 Identities = 72/164 (43%), Positives = 102/164 (62%), Gaps = 4/164 (2%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGP 211 +LNW R IA+ AARG+ +LH P +IHRD+KSSN+L+DE+ ARV+DFG++ +M Sbjct: 982 KLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA 1041 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID-MQLEEGN 388 +D+ +S L AGT GY+ PEYY+ +TK DVYS+GVVLLE+L+G++ D + N Sbjct: 1042 MDTHLSVSTL-AGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTDSADFGDNN 1100 Query: 389 IVEWAAPLIKAGDISGILDPAL--SPPSDPEALKKIAAVACKCV 514 +V W L G I+ + D L S L + VAC C+ Sbjct: 1101 LVGW-VKLHAKGKITDVFDRELLKEDASIEIELLQHLKVACACL 1143
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 121 bits (304), Expect = 1e-27 Identities = 72/164 (43%), Positives = 102/164 (62%), Gaps = 4/164 (2%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGP 211 +LNW R IA+ AARG+ +LH P +IHRD+KSSN+L+DE+ ARV+DFG++ +M Sbjct: 982 KLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA 1041 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID-MQLEEGN 388 +D+ +S L AGT GY+ PEYY+ +TK DVYS+GVVLLE+L+G++ D + N Sbjct: 1042 MDTHLSVSTL-AGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTDSADFGDNN 1100 Query: 389 IVEWAAPLIKAGDISGILDPAL--SPPSDPEALKKIAAVACKCV 514 +V W L G I+ + D L S L + VAC C+ Sbjct: 1101 LVGW-VKLHAKGKITDVFDRELLKEDASIEIELLQHLKVACACL 1143
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 120 bits (301), Expect = 2e-27 Identities = 64/125 (51%), Positives = 87/125 (69%), Gaps = 2/125 (1%) Frame = +2 Query: 32 KQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGP 211 K L W +R+T+A+ ARG+EYLHG A IHRD+K SNIL+ +D A+VADFGL + P Sbjct: 684 KPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAP 743 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID-MQLEEG- 385 G+ + + AGT GYL PEY +TTK DVYSFGV+L+E+++GRK++D Q EE Sbjct: 744 EGKGSIETRI-AGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRKSLDESQPEESI 802 Query: 386 NIVEW 400 ++V W Sbjct: 803 HLVSW 807
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 117 bits (294), Expect = 1e-26 Identities = 65/160 (40%), Positives = 97/160 (60%), Gaps = 2/160 (1%) Frame = +2 Query: 14 RXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFG 193 R ++ L W R IA AA+G+ +LH P +IHRD+KSSN+L+D+D ARV+DFG Sbjct: 927 RTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFG 986 Query: 194 LS-IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDM 370 ++ ++ +D+ +S L AGT GY+ PEYY+ T K DVYS GVV+LEILSG++ D Sbjct: 987 MARLISALDTHLSVSTL-AGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDK 1045 Query: 371 -QLEEGNIVEWAAPLIKAGDISGILDPALSPPSDPEALKK 487 + + N+V W+ + G ++D L E+L + Sbjct: 1046 EEFGDTNLVGWSKMKAREGKHMEVIDEDLLKEGSSESLNE 1085
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 115 bits (289), Expect = 6e-26 Identities = 66/162 (40%), Positives = 96/162 (59%), Gaps = 3/162 (1%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPV 214 L+W R+ IA AA G+ YLH P ++HRDIKSSNIL+ + A +ADFGL+ ++ P Sbjct: 838 LDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPY 897 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG--N 388 D T ++ GTLGY+ PEY + T K DVYSFGVVLLE+L+GR+ +D+ G + Sbjct: 898 D--THVTTDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTGRRPMDVCKPRGSRD 955 Query: 389 IVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 ++ W + S I DP + E + + +AC+C+ Sbjct: 956 LISWVLQMKTEKRESEIFDPFIYDKDHAEEMLLVLEIACRCL 997
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 110 bits (274), Expect = 3e-24 Identities = 58/176 (32%), Positives = 104/176 (59%), Gaps = 5/176 (2%) Frame = +2 Query: 5 CMARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVA 184 C+ + L+W +R IA+ +ARG+ YLH + P +IHRD+K++NIL+DE+ A V Sbjct: 374 CLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVG 433 Query: 185 DFGLS-IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKA 361 DFGL+ +M D T ++ GT+G++ PEY + K+DV+ +GV+LLE+++G++A Sbjct: 434 DFGLAKLMDYKD--THVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRA 491 Query: 362 IDMQL----EEGNIVEWAAPLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 D+ ++ +++W L+K + ++D L E ++++ VA C + Sbjct: 492 FDLARLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQ 547
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 107 bits (267), Expect = 2e-23 Identities = 58/160 (36%), Positives = 94/160 (58%), Gaps = 3/160 (1%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSG 223 W R+ I + AARG+ +LH VI+RD K+SNIL+D +++A+++DFGL+ +GP D Sbjct: 190 WDLRIKIVIGAARGLAFLHSLQ-REVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEK 248 Query: 224 TPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG--NIVE 397 + ++ GT GY PEY +L KSDV++FGVVLLEI++G A + + G ++V+ Sbjct: 249 SHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTKRPRGQESLVD 308 Query: 398 WAAP-LIKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 W P L + I+D + + ++A + C+ Sbjct: 309 WLRPELSNKHRVKQIMDKGIKGQYTTKVATEMARITLSCI 348
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 105 bits (262), Expect = 8e-23 Identities = 55/121 (45%), Positives = 76/121 (62%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L W R +AV+AA+G+ YLH P ++HRD+KS+NIL+D D A VADFGL+ Sbjct: 786 LQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLVDG 845 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVE 397 + + AG+ GY+ PEY + KSDVYSFGVVLLE+++G+K + E +IV Sbjct: 846 AASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGKKPVGEFGEGVDIVR 905 Query: 398 W 400 W Sbjct: 906 W 906
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 104 bits (259), Expect = 2e-22 Identities = 58/147 (39%), Positives = 88/147 (59%), Gaps = 2/147 (1%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 +N K L+W+ R IAV A G+ YLH P ++HRDIK NIL+D D ++DFG++ Sbjct: 905 TNPPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIA 964 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 + + + S GT+GY+ PE + +SDVYS+GVVLLE+++ +KA+D Sbjct: 965 KLLDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKKALDPSFN 1024 Query: 380 -EGNIVEWAAPL-IKAGDISGILDPAL 454 E +IV W + + G+I I+DP+L Sbjct: 1025 GETDIVGWVRSVWTQTGEIQKIVDPSL 1051
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 94.7 bits (234), Expect = 1e-19 Identities = 60/172 (34%), Positives = 94/172 (54%), Gaps = 9/172 (5%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 + +LNW R I ARG+ YLH + +IHRD+K SNIL+D++ +++DFG++ + Sbjct: 619 RSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIF 678 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDM-QLE-E 382 D + GT GY+ PEY + KSDV+SFGV++LEI+SG+K L+ E Sbjct: 679 ERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKKNRGFYNLDYE 738 Query: 383 GNIVEWAAPLIKAGDISGILDPAL-----SPPS--DPEALKKIAAVACKCVR 517 +++ + K G I+DP + S PS P+ + K + CV+ Sbjct: 739 NDLLSYVWSRWKEGRALEIVDPVIVDSLSSQPSIFQPQEVLKCIQIGLLCVQ 790
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 89.7 bits (221), Expect = 4e-18 Identities = 53/114 (46%), Positives = 70/114 (61%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+W R IA AA GI +LH IHRDIKS+NIL+DE A+++DFGL+ Sbjct: 283 LSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKF 339 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 + T ++ GT Y+ PE R +T KSD+YSFGVVLLEI++G A+D E Sbjct: 340 AQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEHRE 392
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 89.4 bits (220), Expect = 6e-18 Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 1/160 (0%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+W R +A A GI +LH IHRDIKS+NIL+D+D A+++DFGL+ Sbjct: 283 LSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASARL 339 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVE 397 + T ++ GT Y+ PE R +T KSD+YSFGVVLLE+++G A+D E +++ Sbjct: 340 AQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLELITGLAAVDENREPQLLLD 398 Query: 398 WAAPL-IKAGDISGILDPALSPPSDPEALKKIAAVACKCV 514 + + I D +S +DP +++ + + A +C+ Sbjct: 399 IKEEIEDEEKTIEDYTDEKMS-DADPASVEAMYSAASQCL 437
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 89.0 bits (219), Expect = 7e-18 Identities = 49/120 (40%), Positives = 73/120 (60%), Gaps = 2/120 (1%) Frame = +2 Query: 14 RXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFG 193 + N L W +R +I++ ARGI +LH P+IH DIK +NIL+D+ ++ DFG Sbjct: 307 KAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFG 366 Query: 194 LSIMGP--VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 L GP +D+ ++++ GT YL PE+ L+T DVYSFG+VLLE+ +GR+ D Sbjct: 367 LVREGPKSLDAVVEVNKV-FGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTD 425
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 86.3 bits (212), Expect = 5e-17 Identities = 55/169 (32%), Positives = 84/169 (49%), Gaps = 10/169 (5%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+W R IA+ A+G+ YLH VIH D+K NIL+D+ ++ DFGL + Sbjct: 627 LDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRG 686 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVE 397 T GTLGY+ PE+ +T K DVYS+GVVLLE+L+G + ++ + Sbjct: 687 GSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTRVSELVGGTDEVHS 746 Query: 398 WAAPLIK------AGD----ISGILDPALSPPSDPEALKKIAAVACKCV 514 L++ G+ I G LD L+ P + + + +A C+ Sbjct: 747 MLRKLVRMLSAKLEGEEQSWIDGYLDSKLNRPVNYVQARTLIKLAVSCL 795
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 85.9 bits (211), Expect = 6e-17 Identities = 59/155 (38%), Positives = 85/155 (54%), Gaps = 1/155 (0%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGL-SIM 205 K LNW RR IA+ ARG+ YLH P+IH +I+S N+L+D+ AR+ +FGL IM Sbjct: 466 KPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIM 525 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG 385 + +S+ A + GY PE +++ +SDVY+FG++LLEIL G+K G Sbjct: 526 VQAVADEIVSQ--AKSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKP-GKSGRNG 582 Query: 386 NIVEWAAPLIKAGDISGILDPALSPPSDPEALKKI 490 N L+KA +L+ D EA+K I Sbjct: 583 NEFVDLPSLVKA----AVLEETTMEVFDLEAMKGI 613
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 82.8 bits (203), Expect = 5e-16 Identities = 46/108 (42%), Positives = 68/108 (62%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 S ++QL+ RR+++A A+G+ YLH PP++HRD+KS N+L+D+ + +V DFGLS Sbjct: 640 SGAREQLDERRRLSMAYDVAKGMNYLHNRN-PPIVHRDLKSPNLLVDKKYTVKVCDFGLS 698 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEI 343 + S S+ AGT ++ PE R KSDVYSFGV+L E+ Sbjct: 699 RLKA--STFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWEL 744
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 82.8 bits (203), Expect = 5e-16 Identities = 62/198 (31%), Positives = 92/198 (46%), Gaps = 36/198 (18%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+W +R+ I + AR I++LH + P +IH DIKSSN+L+DE ++ DFGL+ Sbjct: 310 LSWPQRLDILLGTARAIQFLHQDS-PSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFA 368 Query: 218 SGTPL-------SELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKA----- 361 +P ++ GTL YL EY + L +D +SFGVV+LE L+G++A Sbjct: 369 GSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHG 428 Query: 362 ---------IDMQLEEGNIV---------------EWAAPLIKAGDISGILDPALSPPSD 469 ++ + EE + WAAP I LDP P Sbjct: 429 ARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAP-IAMQIYKKHLDPR-PGPCP 486 Query: 470 PEALKKIAAVACKCVRMR 523 PE + +AC C+ R Sbjct: 487 PELGLGLGQLACCCLHRR 504
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 80.1 bits (196), Expect = 3e-15 Identities = 46/119 (38%), Positives = 68/119 (57%), Gaps = 7/119 (5%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS------ 199 L+W +R+ I + AR I++LH + P +IH DIKSSN+L+DE ++ DFGL+ Sbjct: 310 LSWPQRLDILLGTARAIQFLHQDS-PSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFA 368 Query: 200 -IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQ 373 S + GTL YL EY + L +D +SFGVV+LE L+G++A+ Q Sbjct: 369 GAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQ 427
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/166 (32%), Positives = 92/166 (55%), Gaps = 5/166 (3%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 ++ + + + IA Q A+G++YLH + +IHRD+KS+NI + ED ++ DFGL+ + Sbjct: 544 IETKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATV 600 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQL 376 SG+ E +G++ ++ PE R+ + + +SDVY+FG+VL E+++G QL Sbjct: 601 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTG------QL 654 Query: 377 EEGNIVEWAAPLIKAGDISGILDPALSP--PSDPEALKKIAAVACK 508 NI + G G L P LS + P+A+K++ A K Sbjct: 655 PYSNINNRDQIIFMVG--RGYLSPDLSKVRSNCPKAMKRLMAECLK 698
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/166 (32%), Positives = 92/166 (55%), Gaps = 5/166 (3%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 ++ + + + IA Q A+G++YLH + +IHRD+KS+NI + ED ++ DFGL+ + Sbjct: 106 IETKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATV 162 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQL 376 SG+ E +G++ ++ PE R+ + + +SDVY+FG+VL E+++G QL Sbjct: 163 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTG------QL 216 Query: 377 EEGNIVEWAAPLIKAGDISGILDPALSP--PSDPEALKKIAAVACK 508 NI + G G L P LS + P+A+K++ A K Sbjct: 217 PYSNINNRDQIIFMVG--RGYLSPDLSKVRSNCPKAMKRLMAECLK 260
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/166 (32%), Positives = 92/166 (55%), Gaps = 5/166 (3%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 ++ + + + IA Q A+G++YLH + +IHRD+KS+NI + ED ++ DFGL+ + Sbjct: 154 IETKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATV 210 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQL 376 SG+ E +G++ ++ PE R+ + + +SDVY+FG+VL E+++G QL Sbjct: 211 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTG------QL 264 Query: 377 EEGNIVEWAAPLIKAGDISGILDPALSP--PSDPEALKKIAAVACK 508 NI + G G L P LS + P+A+K++ A K Sbjct: 265 PYSNINNRDQIIFMVG--RGYLSPDLSKVRSNCPKAMKRLMAECLK 308
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/166 (32%), Positives = 92/166 (55%), Gaps = 5/166 (3%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 ++ + + + IA Q A+G++YLH + +IHRD+KS+NI + ED ++ DFGL+ + Sbjct: 584 IETKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATV 640 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQL 376 SG+ E +G++ ++ PE R+ + + +SDVY+FG+VL E+++G QL Sbjct: 641 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTG------QL 694 Query: 377 EEGNIVEWAAPLIKAGDISGILDPALSP--PSDPEALKKIAAVACK 508 NI + G G L P LS + P+A+K++ A K Sbjct: 695 PYSNINNRDQIIFMVG--RGYLSPDLSKVRSNCPKAMKRLMAECLK 738
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/166 (32%), Positives = 92/166 (55%), Gaps = 5/166 (3%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 ++ + + + IA Q A+G++YLH + +IHRD+KS+NI + ED ++ DFGL+ + Sbjct: 584 IETKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATV 640 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQL 376 SG+ E +G++ ++ PE R+ + + +SDVY+FG+VL E+++G QL Sbjct: 641 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTG------QL 694 Query: 377 EEGNIVEWAAPLIKAGDISGILDPALSP--PSDPEALKKIAAVACK 508 NI + G G L P LS + P+A+K++ A K Sbjct: 695 PYSNINNRDQIIFMVG--RGYLSPDLSKVRSNCPKAMKRLMAECLK 738
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/166 (32%), Positives = 92/166 (55%), Gaps = 5/166 (3%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 ++ + + + IA Q A+G++YLH + +IHRD+KS+NI + ED ++ DFGL+ + Sbjct: 170 IETKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATV 226 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQL 376 SG+ E +G++ ++ PE R+ + + +SDVY+FG+VL E+++G QL Sbjct: 227 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTG------QL 280 Query: 377 EEGNIVEWAAPLIKAGDISGILDPALSP--PSDPEALKKIAAVACK 508 NI + G G L P LS + P+A+K++ A K Sbjct: 281 PYSNINNRDQIIFMVG--RGYLSPDLSKVRSNCPKAMKRLMAECLK 324
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 77.0 bits (188), Expect = 3e-14 Identities = 47/112 (41%), Positives = 70/112 (62%), Gaps = 6/112 (5%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPVDS 220 W + + G+ YLH PP++HRD+K SNIL+D + +A++ADFGLS G S Sbjct: 115 WPLLCRLLQEVVLGMCYLHSLD-PPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQS 173 Query: 221 GTPL---SELPAGTLGYLDPE-YYRLHYLTTK-SDVYSFGVVLLEILSGRKA 361 G+ S GTL YLDPE ++++ +K SDVYSFG+++ +L+GR+A Sbjct: 174 GSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREA 225
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 75.9 bits (185), Expect = 6e-14 Identities = 49/157 (31%), Positives = 84/157 (53%), Gaps = 3/157 (1%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG+ Sbjct: 446 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 502 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P G++ ++ PE R+ + + +SDVYS+G+VL E+++G I+ Sbjct: 503 EQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG 562 Query: 407 PLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 + D+S + + P+A+K++ A K VR Sbjct: 563 RGYASPDLSKLY------KNCPKAMKRLVADCLKKVR 593
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 75.5 bits (184), Expect = 8e-14 Identities = 47/121 (38%), Positives = 70/121 (57%), Gaps = 3/121 (2%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPVDS 220 W + + G+ YLH P ++HRD+K SN+L D + + ++ADFGLS G S Sbjct: 114 WPLLCRLLKEVVLGMFYLHDQN-PVLLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQS 172 Query: 221 GTPLSELPAGTLGYLDPEYY--RLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIV 394 GT E P GTLGYL PE + +T SDVYSFG+++ +L+GR+ +++ E + Sbjct: 173 GTGSGE-PGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE-VELPTEPSLVY 230 Query: 395 E 397 E Sbjct: 231 E 231
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 75.5 bits (184), Expect = 8e-14 Identities = 52/151 (34%), Positives = 83/151 (54%), Gaps = 5/151 (3%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + I Q A+G++YLH +IHRD+KS+NI + ED + ++ DFGL+ SG + Sbjct: 526 IDIGRQVAQGMDYLHA---KNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQA 582 Query: 236 ELPAGTLGYLDPEYYRLHYL---TTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 P G++ ++ PE R+ L + +SDVY+FG+V+ E+L+ L G+I Sbjct: 583 NQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLA------ECLPYGHISNKDQ 636 Query: 407 PLIKAGDISGILDPALSP--PSDPEALKKIA 493 L G G+L P +S P+ALK++A Sbjct: 637 ILFMVG--RGLLRPDMSQVRSDAPQALKRLA 665
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 75.1 bits (183), Expect = 1e-13 Identities = 49/107 (45%), Positives = 64/107 (59%), Gaps = 8/107 (7%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI---DEDHN-----ARVADFGLSIMGP 211 V AVQ ARG+ YLH A P+IHRD+KS NILI E+HN ++ DFGL+ Sbjct: 197 VNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLA--RE 254 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T +S AGT ++ PE RL + SDV+SFGV+L E+L+G Sbjct: 255 WHKTTKMS--AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTG 299
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 75.1 bits (183), Expect = 1e-13 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 3/153 (1%) Frame = +2 Query: 8 MARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVAD 187 + R +L + R +Q + Y+HG+ ++HRD+K SNI++D+D R+ D Sbjct: 206 VVREEDLNRPERMGRLKDAMLQICEALAYIHGHG---LVHRDLKPSNIMVDDDRQVRLMD 262 Query: 188 FGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 FGL+ D+ + GT Y+ PE L ++D+YS GV+L E+LSGR D Sbjct: 263 FGLAKFLADDAAITEAGKLVGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFD 322 Query: 368 MQLEE---GNIVEWAAPLIKAGDISGILDPALS 457 + ++E P + A ++ G DP L+ Sbjct: 323 AKTPHELWRQVLETEPPPVLALNLHG--DPQLA 353
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 74.3 bits (181), Expect = 2e-13 Identities = 40/108 (37%), Positives = 67/108 (62%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPV 214 ++ + ++ + AA GI+YLH + P ++HRDIK +NIL+DE N ++ADFG + + Sbjct: 1456 KITFANKLKLLYGAAMGIDYLHS-SNPMIVHRDIKPANILVDEHFNVKIADFGFARI--K 1512 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRK 358 + T ++ GT + PE R K+DV+SFGVV+ E+L+G++ Sbjct: 1513 EDNTTMTR--CGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKE 1558 Score = 63.5 bits (153), Expect = 3e-10 Identities = 35/114 (30%), Positives = 67/114 (58%), Gaps = 4/114 (3%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + L ++ + ++ +A QA++G+ +LH ++HRD+KS N+L+D N +V+DFGL+ Sbjct: 874 NELIPEIPYALKIKMAYQASKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKVSDFGLT 930 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYY----RLHYLTTKSDVYSFGVVLLEILS 349 + ++ GT+ ++ PE + Y+ +DVYSFG++L E+L+ Sbjct: 931 KVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYIL--ADVYSFGIILWELLT 982
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 74.3 bits (181), Expect = 2e-13 Identities = 48/157 (30%), Positives = 84/157 (53%), Gaps = 3/157 (1%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG+ Sbjct: 446 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 502 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P G++ ++ PE R+ + + +SDVYS+G+VL E+++G I+ Sbjct: 503 EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG 562 Query: 407 PLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 + D+S + + P+A+K++ A K V+ Sbjct: 563 RGYASPDLSRLY------KNCPKAMKRLVADCVKKVK 593
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 74.3 bits (181), Expect = 2e-13 Identities = 48/157 (30%), Positives = 84/157 (53%), Gaps = 3/157 (1%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG+ Sbjct: 446 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 502 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P G++ ++ PE R+ + + +SDVYS+G+VL E+++G I+ Sbjct: 503 EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG 562 Query: 407 PLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 + D+S + + P+A+K++ A K V+ Sbjct: 563 RGYASPDLSKLY------KNCPKAMKRLVADCVKKVK 593
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 73.9 bits (180), Expect = 2e-13 Identities = 52/159 (32%), Positives = 87/159 (54%), Gaps = 5/159 (3%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG+ Sbjct: 446 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 502 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P G++ ++ PE R+ + + +SDVYS+G+VL E+++G +L +I Sbjct: 503 EQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAG------ELPYAHINNRDQ 556 Query: 407 PLIKAGDISGILDPALSP--PSDPEALKKIAAVACKCVR 517 + G G P LS + P+A+K++ A K V+ Sbjct: 557 IIFMVG--RGYASPDLSRLYKNCPKAMKRLVADCVKKVK 593
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 73.9 bits (180), Expect = 2e-13 Identities = 52/159 (32%), Positives = 87/159 (54%), Gaps = 5/159 (3%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG+ Sbjct: 121 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 177 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P G++ ++ PE R+ + + +SDVYS+G+VL E+++G +L +I Sbjct: 178 EQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAG------ELPYAHINNRDQ 231 Query: 407 PLIKAGDISGILDPALSP--PSDPEALKKIAAVACKCVR 517 + G G P LS + P+A+K++ A K V+ Sbjct: 232 IIFMVG--RGYASPDLSRLYKNCPKAIKRLVADCVKKVK 268
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 3/157 (1%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + ++ DFGL+ + SG+ Sbjct: 179 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQV 235 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P G++ ++ PE R+ + + +SDVYS+G+VL E+++G I+ Sbjct: 236 EQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG 295 Query: 407 PLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 + D+S + + P+A+K++ A K VR Sbjct: 296 RGYASPDLSKLY------KNCPKAMKRLVADCLKKVR 326
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 72.8 bits (177), Expect = 5e-13 Identities = 40/114 (35%), Positives = 64/114 (56%), Gaps = 6/114 (5%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS---IMGPV 214 W R I + A G+ YLH PP++H D+K+ NIL+D + + ++ADFGLS +M Sbjct: 118 WPLRFRILHEIALGVNYLHNMT-PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLS 176 Query: 215 DSGTPLSELPAGTLGYLDPEYY---RLHYLTTKSDVYSFGVVLLEILSGRKAID 367 S + S GT+ Y+ PE Y + + K D+YS+ V+ E+LS ++ + Sbjct: 177 QSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE 230
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 72.8 bits (177), Expect = 5e-13 Identities = 40/114 (35%), Positives = 65/114 (57%), Gaps = 6/114 (5%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS---IMGPV 214 W R I + A G+ YLH PP++H D+K+ NIL+D + + ++ADFGLS +M Sbjct: 118 WPLRFRILHEIALGVNYLHNMN-PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLS 176 Query: 215 DSGTPLSELPAGTLGYLDPEYY---RLHYLTTKSDVYSFGVVLLEILSGRKAID 367 S + S GT+ Y+ PE Y + + K D+YS+ V++ E+LS ++ + Sbjct: 177 QSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFE 230
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 72.4 bits (176), Expect = 7e-13 Identities = 51/169 (30%), Positives = 89/169 (52%), Gaps = 10/169 (5%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGP-V 214 L+W R+++ + A+ I+YLH VI ++ S+NIL+D+ ++ DF + P + Sbjct: 275 LSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNL 334 Query: 215 DSGTPLSELPAGT---LGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG 385 + + + G L Y+ EY R L+ K+DVYSFG+V++E+L+G K + L++ Sbjct: 335 EQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVV---LDDP 391 Query: 386 NIVEWAAPLIKAGDISGILDPALS------PPSDPEALKKIAAVACKCV 514 V+ L++ + G LD LS PP K+ ++A +CV Sbjct: 392 KHVQLRDLLMELMEKRG-LDSCLSFLDRKIPPCPRNFSAKLFSLAGRCV 439
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 71.6 bits (174), Expect = 1e-12 Identities = 39/112 (34%), Positives = 65/112 (58%), Gaps = 13/112 (11%) Frame = +2 Query: 53 RVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILID-------------EDHNARVADFG 193 R+ +A+ A+G+ YLHG+ PP++HRD+ S NIL+D +D +++DFG Sbjct: 1392 RLKLALDIAKGMNYLHGWT-PPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFG 1450 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 LS + + + G + Y+ PE ++ + KSDVYS+G+VL E+L+ Sbjct: 1451 LSRLKKEQASQMTQSV--GCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLT 1500
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 71.2 bits (173), Expect = 2e-12 Identities = 48/157 (30%), Positives = 87/157 (55%), Gaps = 3/157 (1%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + IA Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG+ Sbjct: 437 IDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQV 493 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E G++ ++ PE R+ + + +SDVYS+G+VL E+++G +L +I + Sbjct: 494 EQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTG------ELPYSHIRDRDQ 547 Query: 407 PLIKAGDISGILDPALSPPSDPEALKKIAAVACKCVR 517 + G + D + + P+A+K++ A + K +R Sbjct: 548 IIFLVGRGGVVPDLSKLYKNCPKAMKRLVADSIKKLR 584
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 70.9 bits (172), Expect = 2e-12 Identities = 45/130 (34%), Positives = 71/130 (54%), Gaps = 3/130 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L W R I + A G+ +LH A PP++H D+K +NIL+D ++ +++DFGL+ + Sbjct: 113 LPWDLRFRIIHETAVGMNFLHCMA-PPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLS 171 Query: 218 SGTPLS-ELPAGTLGYLDPEYYR--LHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGN 388 LS + GT+ YL PE R TK DVYSF +V+ +L+ +K +E N Sbjct: 172 HSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF---ADEKN 228 Query: 389 IVEWAAPLIK 418 I+ ++K Sbjct: 229 ILHIMVKVVK 238
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 70.5 bits (171), Expect = 3e-12 Identities = 46/107 (42%), Positives = 63/107 (58%), Gaps = 8/107 (7%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI-------DEDHNA-RVADFGLSIMGP 211 V AVQ ARG+ YLH A PVIHRD+KS+NIL+ D +H ++ DFGL+ Sbjct: 216 VNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLA--RE 273 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T +S AGT ++ PE + + SDV+SFGV+L E+L+G Sbjct: 274 WHKTTQMS--AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTG 318
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 69.3 bits (168), Expect = 6e-12 Identities = 44/110 (40%), Positives = 66/110 (60%), Gaps = 2/110 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 K+ L+ ++ IAV A+G+EYLH P+IHRD+ S NIL+ ED +A VADFG S + Sbjct: 656 KRILDLQSKLIIAVDVAKGMEYLHNLT-QPIIHRDLNSHNILLYEDGHAVVADFGESRFL 714 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSG 352 +D + G L ++ PE + + T K+DV+S+ + L EIL+G Sbjct: 715 QSLDEDNMTKQ--PGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTG 762
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 69.3 bits (168), Expect = 6e-12 Identities = 45/109 (41%), Positives = 64/109 (58%), Gaps = 3/109 (2%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPVDS 220 W + + G+ YLH P ++HRD+K SN+L+D + +A++ADFGLS G S Sbjct: 115 WPLLCRLLEEVVLGMCYLHSLN-PSLLHRDLKPSNVLLDLELHAKLADFGLSTFQGGSQS 173 Query: 221 GTPL-SELPAGTLGYLDPEYYRLHYLTTK-SDVYSFGVVLLEILSGRKA 361 G+ S GTL YL PE +K SDVYSFGV++ +L+GR+A Sbjct: 174 GSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREA 222
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 69.3 bits (168), Expect = 6e-12 Identities = 45/107 (42%), Positives = 62/107 (57%), Gaps = 8/107 (7%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDE--------DHNARVADFGLSIMGP 211 V AVQ ARG+ YLH A P+IHRD+KSSNILI + + ++ DFGL+ Sbjct: 243 VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLA--RE 300 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T +S AGT ++ PE R + SDV+S+GV+L E+L+G Sbjct: 301 WHRTTKMS--AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTG 345
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 68.9 bits (167), Expect = 8e-12 Identities = 50/159 (31%), Positives = 85/159 (53%), Gaps = 5/159 (3%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + +A Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG Sbjct: 407 IDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPL 463 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAA 406 E P+G++ ++ E R+ + + +SDVY++GVVL E+++G L +I Sbjct: 464 EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG------SLPYSHIGSRDQ 517 Query: 407 PLIKAGDISGILDPALSPPSD--PEALKKIAAVACKCVR 517 + G G L P LS S P+A++++ + K R Sbjct: 518 IIFMVG--RGYLSPDLSKISSNCPKAMRRLLSDCLKFQR 554
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 68.6 bits (166), Expect = 1e-11 Identities = 37/102 (36%), Positives = 64/102 (62%), Gaps = 3/102 (2%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + +A Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG Sbjct: 405 IDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPL 461 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSG 352 E P+G++ ++ E R+ + + +SDVY++GVVL E+++G Sbjct: 462 EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 503
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 68.6 bits (166), Expect = 1e-11 Identities = 37/102 (36%), Positives = 64/102 (62%), Gaps = 3/102 (2%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + +A Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG Sbjct: 405 IDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPL 461 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSG 352 E P+G++ ++ E R+ + + +SDVY++GVVL E+++G Sbjct: 462 EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 503
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 68.6 bits (166), Expect = 1e-11 Identities = 43/110 (39%), Positives = 66/110 (60%), Gaps = 2/110 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 K+ L+ ++ IAV A+G+EYLH P+IHRD+ S NIL+ ED +A VADFG S + Sbjct: 554 KRILDLQSKLIIAVDVAKGMEYLHSLT-QPIIHRDLNSHNILLYEDGHAVVADFGESRFL 612 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSG 352 +D + G L ++ PE + + T K+DV+S+ + L E+L+G Sbjct: 613 QSLDEDNMTKQ--PGNLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLTG 660
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 68.6 bits (166), Expect = 1e-11 Identities = 37/102 (36%), Positives = 64/102 (62%), Gaps = 3/102 (2%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + +A Q A+G++YLH +IHRD+KS+NI + E ++ DFGL+ + SG Sbjct: 407 IDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPL 463 Query: 236 ELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILSG 352 E P+G++ ++ E R+ + + +SDVY++GVVL E+++G Sbjct: 464 EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 505
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 67.4 bits (163), Expect = 2e-11 Identities = 43/110 (39%), Positives = 65/110 (59%), Gaps = 2/110 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 K+ L+ ++ IAV A+G+EYLH P+IHRD+ S NIL+ ED +A VADFG S + Sbjct: 553 KRILDLQSKLIIAVDVAKGMEYLHSLT-QPIIHRDLNSHNILLYEDGHAVVADFGESRFL 611 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSG 352 +D + G L ++ PE + + T K+DV+S+ + L E+L G Sbjct: 612 QSLDEDNMTKQ--PGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLIG 659
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 67.4 bits (163), Expect = 2e-11 Identities = 46/142 (32%), Positives = 76/142 (53%), Gaps = 2/142 (1%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSEL 241 I+V RG+ YL ++HRD+K SN+L++ + ++ DFG+S M +DS ++ Sbjct: 174 ISVAVVRGLTYLKDEI--KILHRDVKPSNMLVNSNGEIKLCDFGVSGM-LIDS---MANS 227 Query: 242 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAI--DMQLEEGNIVEWAAPLI 415 GT Y+ PE + T SD++SFG+ L+E+L GR + Q E + A I Sbjct: 228 FVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENEI 287 Query: 416 KAGDISGILDPALSPPSDPEAL 481 + D + +P PPS+P ++ Sbjct: 288 ELAD--SLEEPNYHPPSNPASM 307
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 67.0 bits (162), Expect = 3e-11 Identities = 37/94 (39%), Positives = 59/94 (62%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSEL 241 +A+ +RG+EYLH VIHRD+KS+N+L++++ +VADFG S + ++ ++ Sbjct: 192 LALDISRGMEYLHSQG---VIHRDLKSNNLLLNDEMRVKVADFGTSCL---ETQCREAKG 245 Query: 242 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEI 343 GT ++ PE + T K DVYSFG+VL E+ Sbjct: 246 NMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWEL 279
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 66.2 bits (160), Expect = 5e-11 Identities = 42/107 (39%), Positives = 62/107 (57%), Gaps = 8/107 (7%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDE--------DHNARVADFGLSIMGP 211 V AVQ ARG+ YLH A P++HRD+KSSNIL+ E + ++ DFGL+ Sbjct: 238 VNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA--RE 295 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T +S AGT ++ PE + + SD++S+GV+L E+L+G Sbjct: 296 WHRTTKMS--TAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTG 340
>PKPA_PHYBL (Q01577) Serine/threonine-protein kinase pkpA (EC 2.7.11.1)| Length = 613 Score = 65.9 bits (159), Expect = 7e-11 Identities = 45/145 (31%), Positives = 68/145 (46%), Gaps = 1/145 (0%) Frame = +2 Query: 23 NLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNA-RVADFGLS 199 N+K W R++ +G+ YLHG+ PP+IHRDIK NI I+ H ++ D G + Sbjct: 111 NIKIVKRWCRQIL------KGLAYLHGHE-PPIIHRDIKCDNIFINGAHGEIKIGDMGTA 163 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 M T + GT ++ PE Y K D+Y+FG+ LLE+ +G Sbjct: 164 EMKNGKKYTVI-----GTPEFMAPEMYEEQGYNEKVDIYAFGMCLLEMATGEYPYGECTN 218 Query: 380 EGNIVEWAAPLIKAGDISGILDPAL 454 + + IK +S + DP L Sbjct: 219 AVQVFKKVTQTIKPECLSRVQDPEL 243
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 64.7 bits (156), Expect = 1e-10 Identities = 35/83 (42%), Positives = 50/83 (60%) Frame = +2 Query: 119 VIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLT 298 ++HRDIK NILID N +V DFG++ + T + + G++ YL PE R T Sbjct: 130 IVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHTNSV-LGSVHYLSPEQARGGLAT 188 Query: 299 TKSDVYSFGVVLLEILSGRKAID 367 KSD+Y+ G+VL E+L+GR D Sbjct: 189 KKSDIYALGIVLFELLTGRIPFD 211
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 2/103 (1%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R + + A + + + H +IHRD+K +NI+I + +V DFG++ DSG Sbjct: 114 RAIEVIADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIA-RAIADSGNS 169 Query: 230 LSELPA--GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 +++ A GT YL PE R + +SDVYS G VL E+L+G Sbjct: 170 VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTG 212
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 2/103 (1%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R + + A + + + H +IHRD+K +NI+I + +V DFG++ DSG Sbjct: 114 RAIEVIADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIA-RAIADSGNS 169 Query: 230 LSELPA--GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 +++ A GT YL PE R + +SDVYS G VL E+L+G Sbjct: 170 VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTG 212
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 64.3 bits (155), Expect = 2e-10 Identities = 33/94 (35%), Positives = 53/94 (56%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+ YLH + HRD+K N+L+DE N +++DFG++ M L + G Sbjct: 126 QLLSGLNYLHQRG---IAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCG 182 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 TL Y+ PE + Y +D++S GV+L+ +L+G Sbjct: 183 TLPYVAPEVLQKAYHAQPADLWSCGVILVTMLAG 216
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 64.3 bits (155), Expect = 2e-10 Identities = 38/98 (38%), Positives = 56/98 (57%), Gaps = 2/98 (2%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSE--LP 244 QAA G+ +H ++HRDIK N+LI + ++ DFG++ + PL+ + Sbjct: 131 QAAHGLSVIHRMG---LVHRDIKPGNMLITANGILKITDFGIA---KAAASVPLTRTGMV 184 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRK 358 GT Y+ PE + H +T SDVYS GVV E+LSGR+ Sbjct: 185 VGTAQYVSPEQAQGHQVTPASDVYSLGVVGYEMLSGRR 222
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 63.9 bits (154), Expect = 3e-10 Identities = 38/97 (39%), Positives = 59/97 (60%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSE 238 T Q G++YLHG VIHRDIK++NIL+ D+ ++ADFG+S + V+S + Sbjct: 125 TYVTQTLLGLKYLHGEG---VIHRDIKAANILLSADNTVKLADFGVSTI--VNSS---AL 176 Query: 239 LPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 AGTL ++ PE +T SD++S G ++E+L+ Sbjct: 177 TLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLT 213
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/92 (42%), Positives = 57/92 (61%) Frame = +2 Query: 77 ARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTL 256 A G+ YLH + +IHRD+KS N+LI D +++DFG S D T +S AGT+ Sbjct: 254 AGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTS-KELSDKSTKMSF--AGTV 307 Query: 257 GYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 ++ PE R ++ K D++SFGVVL E+L+G Sbjct: 308 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 339
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/92 (42%), Positives = 57/92 (61%) Frame = +2 Query: 77 ARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTL 256 A G+ YLH + +IHRD+KS N+LI D +++DFG S D T +S AGT+ Sbjct: 254 AGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTS-KELSDKSTKMSF--AGTV 307 Query: 257 GYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 ++ PE R ++ K D++SFGVVL E+L+G Sbjct: 308 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 339
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/92 (42%), Positives = 57/92 (61%) Frame = +2 Query: 77 ARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTL 256 A G+ YLH + +IHRD+KS N+LI D +++DFG S D T +S AGT+ Sbjct: 221 AGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTS-KELSDKSTKMSF--AGTV 274 Query: 257 GYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 ++ PE R ++ K D++SFGVVL E+L+G Sbjct: 275 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 306
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 63.9 bits (154), Expect = 3e-10 Identities = 38/92 (41%), Positives = 56/92 (60%) Frame = +2 Query: 77 ARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTL 256 A G+ YLH + +IHRD+KS N+L+ +++DFG S D T +S AGT+ Sbjct: 264 ASGMNYLHLHK---IIHRDLKSPNVLVTHTDAVKISDFGTS-KELSDKSTKMSF--AGTV 317 Query: 257 GYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 +L PE R ++ K D++SFGVVL E+L+G Sbjct: 318 AWLAPEVIRNEPVSEKVDIWSFGVVLWELLTG 349
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 63.9 bits (154), Expect = 3e-10 Identities = 49/172 (28%), Positives = 82/172 (47%), Gaps = 10/172 (5%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGL----SIM 205 L W R+ I + ++ I YLH VI I S+NIL+D+ ++ DF + S + Sbjct: 262 LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHL 321 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG 385 ++ + L Y+ EY R L+ K+DVYSFG+V++E+L+G + + L++ Sbjct: 322 EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVV---LDDP 378 Query: 386 NIVEWAAPLIKAGDISGILDPALS------PPSDPEALKKIAAVACKCVRMR 523 ++ L + + G LD LS PP K+ +A +C R Sbjct: 379 KHIQLRDLLRELMEKRG-LDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATR 429
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 63.5 bits (153), Expect = 3e-10 Identities = 42/127 (33%), Positives = 66/127 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 SN ++++ +T A A+G+ YLH A VIHRD+KS N++I D ++ DFG S Sbjct: 96 SNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGAS 155 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 + L GT ++ PE + ++ D YS+GVVL E+L+ + + + Sbjct: 156 RFHNHTTHMSL----VGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT--REVPFKGL 209 Query: 380 EGNIVEW 400 EG V W Sbjct: 210 EGLQVAW 216
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 63.5 bits (153), Expect = 3e-10 Identities = 39/107 (36%), Positives = 58/107 (54%), Gaps = 8/107 (7%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDE--------DHNARVADFGLSIMGP 211 V A+Q ARG+ YLH A +IHRD+KSSN+LI E ++ DFGL+ Sbjct: 239 VNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA---- 294 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + AGT ++ PE + + SDV+S+GV+L E+++G Sbjct: 295 REMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITG 341
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 63.5 bits (153), Expect = 3e-10 Identities = 42/127 (33%), Positives = 66/127 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 SN ++++ +T A A+G+ YLH A VIHRD+KS N++I D ++ DFG S Sbjct: 96 SNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGAS 155 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 + L GT ++ PE + ++ D YS+GVVL E+L+ + + + Sbjct: 156 RFHNHTTHMSL----VGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT--REVPFKGL 209 Query: 380 EGNIVEW 400 EG V W Sbjct: 210 EGLQVAW 216
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 63.2 bits (152), Expect = 4e-10 Identities = 37/114 (32%), Positives = 66/114 (57%), Gaps = 4/114 (3%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L W +RV+I +EYLHG +IH ++KSSN+L+D++ ++A ++ + PV+ Sbjct: 307 LPWPQRVSICSGLLCAVEYLHGLE---IIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVN 362 Query: 218 SGTPLSELPAGTL----GYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 + + + L YL ++ R+ LT + D++S G+VL E+L+G A+D Sbjct: 363 KRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMD 416
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 63.2 bits (152), Expect = 4e-10 Identities = 37/92 (40%), Positives = 56/92 (60%) Frame = +2 Query: 77 ARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTL 256 A G+ YLH + +IHRD+KS N+L+ +++DFG S D T +S AGT+ Sbjct: 264 ASGMNYLHLHK---IIHRDLKSPNVLVTHTDAVKISDFGTS-KELSDKSTKMSF--AGTV 317 Query: 257 GYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 ++ PE R ++ K D++SFGVVL E+L+G Sbjct: 318 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 349
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 63.2 bits (152), Expect = 4e-10 Identities = 38/104 (36%), Positives = 57/104 (54%), Gaps = 1/104 (0%) Frame = +2 Query: 83 GIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTLGY 262 G+ Y H ++HRD+K N+L+D +N ++ADFG M +++ L E G+ Y Sbjct: 143 GVSYCHALG---IVHRDLKPENLLLDHKYNIKIADFG---MAALETEGKLLETSCGSPHY 196 Query: 263 LDPEYYR-LHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNI 391 PE + Y SDV+S GV+L +L+GR D E+GNI Sbjct: 197 AAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDE--EDGNI 238
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 62.8 bits (151), Expect = 6e-10 Identities = 41/121 (33%), Positives = 60/121 (49%), Gaps = 13/121 (10%) Frame = +2 Query: 23 NLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI 202 N+ Q W++RV+ A A G+ YLH +IHRD+ S N L+ E+ N VADFGL+ Sbjct: 427 NMDSQYPWSQRVSFAKDIASGMAYLHSMN---IIHRDLNSHNCLVRENRNVVVADFGLAR 483 Query: 203 MGPVDSGTPLSELPA-------------GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEI 343 + +D +L + G ++ PE K DV+SFG+VL EI Sbjct: 484 L-MIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEI 542 Query: 344 L 346 + Sbjct: 543 I 543
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 62.8 bits (151), Expect = 6e-10 Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 7/128 (5%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDED---HNARVADFGLSIMGPVDS 220 R + + Q A G+ +H +IHRD+K N+ I + AR+ DFG++ + D+ Sbjct: 111 RALPLLQQLAEGLAAIHDKG---IIHRDLKPENVFISKSARGEQARLLDFGIARLVEPDA 167 Query: 221 GTPLSELPA--GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIV 394 + +S++ GT YL PE + T+SD+YSFGV+ +LSGR D L + Sbjct: 168 ASSVSQIGVVLGTPEYLSPEQAVGAKVDTRSDLYSFGVLTYRVLSGRLPFDGPLPRNFLS 227 Query: 395 EW--AAPL 412 + AAPL Sbjct: 228 QHASAAPL 235
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 62.8 bits (151), Expect = 6e-10 Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 1/122 (0%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 ++ +N R++ I GI Y H ++HRD+K N+L+D +N ++ADFG M Sbjct: 127 REAINCFRQIII------GISYCHALG---IVHRDLKPENLLLDSFYNIKIADFG---MA 174 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYR-LHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEG 385 + + L E G+ Y PE L Y SDV+S GV+L +L+GR D E G Sbjct: 175 ALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDE--ENG 232 Query: 386 NI 391 N+ Sbjct: 233 NV 234
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 62.8 bits (151), Expect = 6e-10 Identities = 44/118 (37%), Positives = 66/118 (55%), Gaps = 3/118 (2%) Frame = +2 Query: 5 CMARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVA 184 C N ++QL+ V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++A Sbjct: 584 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC---IHRDLAARNVLVTEDNVMKIA 640 Query: 185 DFGLS-IMGPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 DFGL+ + +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLP---VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 695
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 62.8 bits (151), Expect = 6e-10 Identities = 44/118 (37%), Positives = 66/118 (55%), Gaps = 3/118 (2%) Frame = +2 Query: 5 CMARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVA 184 C N ++QL+ V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++A Sbjct: 584 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC---IHRDLAARNVLVTEDNVMKIA 640 Query: 185 DFGLS-IMGPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 DFGL+ + +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLP---VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 695
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 62.8 bits (151), Expect = 6e-10 Identities = 44/118 (37%), Positives = 66/118 (55%), Gaps = 3/118 (2%) Frame = +2 Query: 5 CMARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVA 184 C N ++QL+ V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++A Sbjct: 584 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC---IHRDLAARNVLVTEDNVMKIA 640 Query: 185 DFGLS-IMGPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 DFGL+ + +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLP---VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 695
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 62.8 bits (151), Expect = 6e-10 Identities = 39/100 (39%), Positives = 55/100 (55%) Frame = +2 Query: 68 VQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPA 247 V AA G + G+ +HRD+K N+LI +D +VADFGL + VDS T + Sbjct: 125 VLAALGAAHRAGF-----VHRDMKPENVLIGDDGRVKVADFGL--VRAVDSVTNTTGTVL 177 Query: 248 GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 GT+ YL PE + DVY+ G++L E+L+G K D Sbjct: 178 GTVSYLAPEQIEHGTADPRVDVYACGILLYEMLTGEKPHD 217
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 62.8 bits (151), Expect = 6e-10 Identities = 36/96 (37%), Positives = 57/96 (59%), Gaps = 1/96 (1%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDH-NARVADFGLSIMGPVDSGTPLSEL 241 A+Q A+ + YLH P++HRDIK N+L+ H + ++ DFGL+ D +++ Sbjct: 112 ALQCAKALAYLHSLD-RPIVHRDIKPQNMLLYNQHEDLKICDFGLA----TDMSNNKTDM 166 Query: 242 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 GTL Y+ PE + T K DVYSFG++L E+++ Sbjct: 167 Q-GTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMT 201
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 62.4 bits (150), Expect = 7e-10 Identities = 36/102 (35%), Positives = 60/102 (58%), Gaps = 8/102 (7%) Frame = +2 Query: 119 VIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLT 298 V+HRDIK +NI +DE+++ ++ DFGLS + +D+ ++ GT Y+ PE R + Sbjct: 147 VLHRDIKPANIFLDENNSVKLGDFGLSKL--LDNTRVFTQSYVGTPYYMSPEIIRSSPYS 204 Query: 299 TKSDVYSFGVVLLEI------LSGRKAIDMQ--LEEGNIVEW 400 KSDV++ G V+ EI GR +++Q + +GN+ W Sbjct: 205 AKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCW 246
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 62.4 bits (150), Expect = 7e-10 Identities = 36/95 (37%), Positives = 53/95 (55%), Gaps = 1/95 (1%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+ YLHG + HRDIK N+L+DE N +++DFGL+ + ++ L G Sbjct: 113 QLMAGVVYLHGIG---ITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCG 169 Query: 251 TLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSG 352 TL Y+ PE R + DV+S G+VL +L+G Sbjct: 170 TLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAG 204
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 62.4 bits (150), Expect = 7e-10 Identities = 44/113 (38%), Positives = 59/113 (52%), Gaps = 3/113 (2%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHN---ARVADF 190 SNL L WT RV +A A G+ YLH + HRD+ S N LI D N A VADF Sbjct: 144 SNL--HLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADF 198 Query: 191 GLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 GL+ P S G+ ++ PE R K+DV+S+G++L EI++ Sbjct: 199 GLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 62.4 bits (150), Expect = 7e-10 Identities = 47/151 (31%), Positives = 74/151 (49%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R V IA Q R +++ H +IHRDIK NIL+ ++ +V DFG++ + T Sbjct: 110 RAVEIASQVCRALDHAHKNK---IIHRDIKPQNILVTDEDVVKVTDFGIARAANGATITY 166 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAAP 409 ++ GT Y PE + + ++D+YS G+VL E+L+G+ + E + + A Sbjct: 167 TGDV-IGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGK----VPFEGDSPISVALK 221 Query: 410 LIKAGDISGILDPALSPPSDPEALKKIAAVA 502 I+ IL P+ PE L KI A Sbjct: 222 HIQ----EDILPPSRLNEKVPEELDKIVLKA 248
>SPKA_SYNY3 (Q9FAB3) Serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 521 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/120 (35%), Positives = 67/120 (55%), Gaps = 7/120 (5%) Frame = +2 Query: 14 RXSNLKKQLNWTRRVTIAVQAA-RGIEYLHGYACPPVIHRDIKSSNILIDED----HNAR 178 R +++ L R++ + A +GI Y G ACP V+HRDIK SN+L+ ED + Sbjct: 110 RPLKVERFLKIARQICFGLDCAHKGIIY-QGEACP-VVHRDIKPSNVLLVEDPALGELVK 167 Query: 179 VADFGLS--IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + DFG++ + +S T + GTL Y PE L ++SD+YS GV++ E+L+G Sbjct: 168 ILDFGIAKLVQAAEESKT---QAFMGTLAYCSPEQMEGKELDSRSDIYSLGVMMYEMLTG 224
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/110 (38%), Positives = 65/110 (59%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++QL++ V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++ADFGL+ + Sbjct: 590 EEQLSFKDLVSCAYQVARGMEYLASKKC---IHRDLAARNVLVTEDNVMKIADFGLARDI 646 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 647 HHIDYYKKTTNGRLP---VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 693
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 62.0 bits (149), Expect = 1e-09 Identities = 38/127 (29%), Positives = 65/127 (51%), Gaps = 1/127 (0%) Frame = +2 Query: 23 NLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI-DEDHNARVADFGLS 199 +L ++W R Q A G+ YLH P+IHRD+K N+L+ ++ N ++ DFG Sbjct: 110 SLAHAMSWAR------QCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGT- 162 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 D T ++ G+ ++ PE + T K D++S+ +VL E+LS RK ++ Sbjct: 163 ---VADKSTMMTN-NRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLS-RKQPFKGID 217 Query: 380 EGNIVEW 400 ++W Sbjct: 218 NAYTIQW 224
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/110 (38%), Positives = 64/110 (58%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++QL + V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++ADFGL+ + Sbjct: 580 EEQLTFKDLVSCAYQVARGMEYLASQKC---IHRDLAARNVLVTEDNVMKIADFGLARDV 636 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 637 HNIDYYKKTTNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 683
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/107 (38%), Positives = 56/107 (52%), Gaps = 3/107 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHN---ARVADFGLSIMG 208 L WT RV +A A G+ YLH + HRD+ S N LI D N A VADFGL+ Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P S G+ ++ PE R K+DV+S+G++L EI++ Sbjct: 205 PDASIGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 61.6 bits (148), Expect = 1e-09 Identities = 36/95 (37%), Positives = 53/95 (55%), Gaps = 1/95 (1%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+ YLHG + HRDIK N+L+DE N +++DFGL+ + ++ L G Sbjct: 113 QLMAGVVYLHGIG---ITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCG 169 Query: 251 TLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSG 352 TL Y+ PE R + DV+S G+VL +L+G Sbjct: 170 TLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAG 204
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 61.6 bits (148), Expect = 1e-09 Identities = 36/95 (37%), Positives = 53/95 (55%), Gaps = 1/95 (1%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+ YLHG + HRDIK N+L+DE N +++DFGL+ + ++ L G Sbjct: 113 QLMAGVVYLHGIG---ITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCG 169 Query: 251 TLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSG 352 TL Y+ PE R + DV+S G+VL +L+G Sbjct: 170 TLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAG 204
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/107 (38%), Positives = 56/107 (52%), Gaps = 3/107 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHN---ARVADFGLSIMG 208 L WT RV +A A G+ YLH + HRD+ S N LI D N A VADFGL+ Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P S G+ ++ PE R K+DV+S+G++L EI++ Sbjct: 205 PDASIGREKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/94 (41%), Positives = 49/94 (52%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A + YLH VIHRDIK NIL+ D +++DFG S+ P + T L G Sbjct: 195 QMANALSYLHK---KHVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRTTL----CG 247 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 TL YL PE T K D++S GV+ E L G Sbjct: 248 TLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVG 281
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/111 (33%), Positives = 61/111 (54%), Gaps = 4/111 (3%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L W ++ I + + + +LH PP++H D+K NIL+D + + +++DFGLS Sbjct: 127 LCWPLKLRIIHETSLAMNFLHSIK-PPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQS 185 Query: 218 SGTPLSELPA--GTLGYLDPEYYRLHYLT--TKSDVYSFGVVLLEILSGRK 358 + E A GTL Y+ PE + + + DVYSF +V+ EIL+ +K Sbjct: 186 TQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKK 236
>JAK3_HUMAN (P52333) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 61.2 bits (147), Expect = 2e-09 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 + +L+ +R + + Q +G+EYL C +HRD+ + NIL++ + + ++ADFGL+ + Sbjct: 918 RARLDASRLLLYSSQICKGMEYLGSRRC---VHRDLAARNILVESEAHVKIADFGLAKLL 974 Query: 209 PVDSGTPLSELPA-GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P+D + P + + PE + + +SDV+SFGVVL E+ + Sbjct: 975 PLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT 1022
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (CD333 antigen) Length = 806 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/110 (38%), Positives = 64/110 (58%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++QL + V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++ADFGL+ + Sbjct: 586 EEQLTFKDLVSCAYQVARGMEYLASQKC---IHRDLAARNVLVTEDNVMKIADFGLARDV 642 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 643 HNLDYYKKTTNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 689
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/121 (34%), Positives = 60/121 (49%), Gaps = 13/121 (10%) Frame = +2 Query: 23 NLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI 202 ++ Q W++RV+ A A G+ YLH +IHRD+ S N L+ E+ N VADFGL+ Sbjct: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMN---IIHRDLNSHNCLVRENKNVVVADFGLAR 483 Query: 203 MGPVDSGTPLSELPA-------------GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEI 343 + VD T L + G ++ PE K DV+SFG+VL EI Sbjct: 484 L-MVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEI 542 Query: 344 L 346 + Sbjct: 543 I 543
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/150 (27%), Positives = 75/150 (50%), Gaps = 3/150 (2%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPVDSGT 226 R + + + + +EY H ++HRDIK +N+++ + +V DFG++ MG DSG Sbjct: 114 RTLEMTIGILQALEYSHRAG---IVHRDIKPANVMLTRNGQVKVMDFGIARAMG--DSGM 168 Query: 227 PLSELPA--GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEW 400 +++ A GT YL PE + + +SD+YS G +L E+L+ R + + + Sbjct: 169 TMTQTAAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPF---VGDSPVAVA 225 Query: 401 AAPLIKAGDISGILDPALSPPSDPEALKKI 490 + + + DP ++P D LK + Sbjct: 226 YQHVREEPQAPSVFDPEITPEMDAIVLKAL 255
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.8 bits (146), Expect = 2e-09 Identities = 32/111 (28%), Positives = 62/111 (55%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPV 214 ++ + + + A Q A+ + + H ++HRDIK NI++ +D +V DFG++ Sbjct: 104 KIEFNKIIDYATQIAKALNFAHKNG---IVHRDIKPHNIMVTDDDIIKVTDFGIAKASNE 160 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 + T +++ G+ YL PE + + ++D+YSFG+VL E+ +G+ D Sbjct: 161 STITTTNKV-VGSAHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVPYD 210
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 60.5 bits (145), Expect = 3e-09 Identities = 40/110 (36%), Positives = 58/110 (52%), Gaps = 6/110 (5%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI---DEDHNARVADFGLSIMG 208 L+W R+ +A+ ARG+ YLH V HRD+ S N L+ D A V DFGL+ Sbjct: 147 LSWPVRLHLALDIARGLRYLHSKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI 203 Query: 209 PVDSGTPLSELPAGTLG---YLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 PV E P +G ++ PE R K+DV++FG+VL E+++ Sbjct: 204 PVYREGARKE-PLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 252
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 60.5 bits (145), Expect = 3e-09 Identities = 39/108 (36%), Positives = 61/108 (56%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 +N + + ++ A G+EYL ++HRD+ + NIL+ ED A+V+DFGL+ Sbjct: 324 VNTAQLLQFSLHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLA--KAER 378 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKA 361 G S LP + + PE + T+KSDV+SFGV+L E+ S +A Sbjct: 379 KGLDSSRLP---VKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRA 423
>RIPK5_XENLA (Q67E01) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 916 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/109 (34%), Positives = 57/109 (52%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 LK L+ R+ IA+ GI +LH V+HRDIK N+L+D+ H A++ D G Sbjct: 734 LKTGLSLETRLQIALDVVEGIRFLHNQG---VVHRDIKLKNVLLDKKHRAKITDLGFCKP 790 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 791 EAMMSGSIV-----GTPIHMAPELFSGKY-DNSVDVYAFGILFWYICSG 833
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 60.5 bits (145), Expect = 3e-09 Identities = 37/104 (35%), Positives = 61/104 (58%), Gaps = 6/104 (5%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNI-LIDEDHNARVADFGLSIMGP--VDSGT 226 + I Q + G+ YLH +IHRD+K++NI L+D+ ++ DFGL+ + +G Sbjct: 580 IDILKQVSLGMNYLHS---KNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGG 636 Query: 227 PLSELPAGTLGYLDPEYYRL---HYLTTKSDVYSFGVVLLEILS 349 + P G++ ++ PE R+ + T +SDVYSFG+ + EILS Sbjct: 637 QQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILS 680
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/110 (34%), Positives = 58/110 (52%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSEL 241 IA RG+ YLH VIHRDIK NIL++E+ ++ DFG+S ++ L+ Sbjct: 329 IAEAVLRGLSYLHE---KKVIHRDIKPQNILLNENGQVKLCDFGVS----GEAVNSLATT 381 Query: 242 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNI 391 GT Y+ PE + + SDV+S G+ +LE+ +G+ + NI Sbjct: 382 FTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANI 431
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 60.5 bits (145), Expect = 3e-09 Identities = 39/118 (33%), Positives = 60/118 (50%), Gaps = 1/118 (0%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q R +++ H V HRD+K N+L+DE N +++DFGLS + L G Sbjct: 117 QLVRAVDFCHSRG---VCHRDLKPENLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCG 173 Query: 251 TLGYLDPEYY-RLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAAPLIKA 421 T Y+ PE R Y K+DV+S GV+L +L+G + + N++E + KA Sbjct: 174 TPAYVAPEVISRNGYDGFKADVWSCGVILFVLLAGY----LPFRDSNLMELYKKIGKA 227
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/99 (38%), Positives = 58/99 (58%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 A+ A G+EYL ++HRD+ + NIL+ ED A+V+DFGL+ + G S LP Sbjct: 292 ALHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLA-KAELRKGLDSSRLP 347 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKA 361 + + PE + ++KSDV+SFGV+L E+ S +A Sbjct: 348 ---VKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRA 383
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 60.1 bits (144), Expect = 4e-09 Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++QL V+ A Q ARG+EYL C IHRD+ + N+L+ ED+ ++ADFGL+ + Sbjct: 580 EEQLTCKDLVSCAYQVARGMEYLASQKC---IHRDLAARNVLVTEDNVMKIADFGLARDV 636 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 637 HNLDYYKKTTNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 683
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 60.1 bits (144), Expect = 4e-09 Identities = 34/99 (34%), Positives = 51/99 (51%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + I A + + + H +IHRD+K +NI+I + +V DFG++ + + Sbjct: 116 IEIVADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSTSVTQT 172 Query: 236 ELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 GT YL PE R + +SDVYS G VL EIL+G Sbjct: 173 AAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTG 211
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 60.1 bits (144), Expect = 4e-09 Identities = 34/106 (32%), Positives = 57/106 (53%) Frame = +2 Query: 32 KQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGP 211 K+ N + V + + + G+ YL V+HRD+++ NIL+ D +VADFGL+ + Sbjct: 312 KKTNLNQMVHMMAEISEGMAYLES---EKVVHRDLRADNILVANDLTRKVADFGLTELTD 368 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 G + + PE + T+KSDV+S+G+V+ EIL+ Sbjct: 369 GSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILT 414
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.1 bits (144), Expect = 4e-09 Identities = 41/120 (34%), Positives = 59/120 (49%), Gaps = 12/120 (10%) Frame = +2 Query: 23 NLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI 202 ++ Q W++RV+ A A G+ YLH +IHRD+ S N L+ E+ N VADFGL+ Sbjct: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMN---IIHRDLNSHNCLVRENRNVVVADFGLAR 483 Query: 203 MGPVDSG--TPLSELP----------AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEIL 346 + + G L L G ++ PE K DV+SFG+VL EI+ Sbjct: 484 LMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII 543
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 60.1 bits (144), Expect = 4e-09 Identities = 32/106 (30%), Positives = 58/106 (54%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 K +L + I ++ +GI++LH +IHRDIKS N+L+D N ++ DFG Sbjct: 403 KSKLTEAQIARICLETCKGIQHLHARN---IIHRDIKSDNVLLDNSGNIKITDFG--FCA 457 Query: 209 PVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEIL 346 + + T GT ++ PE + + TK D++S G++++E++ Sbjct: 458 RLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMI 503
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 60.1 bits (144), Expect = 4e-09 Identities = 40/109 (36%), Positives = 59/109 (54%), Gaps = 5/109 (4%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI---DEDHNARVADFGLSIMG 208 L+W R+ +A+ A+G+ YLH V HRD+ S N L+ D A V DFGL+ Sbjct: 142 LSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI 198 Query: 209 PV-DSGTPLSELPA-GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 PV GT L G+ ++ PE R K+DV++FG+VL E+++ Sbjct: 199 PVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 247
>JAK3_RAT (Q63272) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1100 Score = 60.1 bits (144), Expect = 4e-09 Identities = 34/108 (31%), Positives = 62/108 (57%), Gaps = 1/108 (0%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 + +L+ R + A Q +G+EYL C +HRD+ + NIL++ + + ++ADFGL+ + Sbjct: 914 RARLHNDRLLLFAWQICKGMEYLGARRC---VHRDLAARNILVESEAHVKIADFGLAKLL 970 Query: 209 PVDSGTPLSELPA-GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P+ + +P + + PE + + +SDV+SFGVVL E+ + Sbjct: 971 PLGKDYYVVRVPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT 1018
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 59.7 bits (143), Expect = 5e-09 Identities = 31/78 (39%), Positives = 47/78 (60%) Frame = +2 Query: 119 VIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLT 298 ++HRD+K NILI +D + ++ADFGL + + + + GT YL PE R Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGL-VRAVAAASITSTGVILGTAAYLSPEQVRDGNAD 196 Query: 299 TKSDVYSFGVVLLEILSG 352 +SDVYS GV++ E+L+G Sbjct: 197 PRSDVYSVGVLVYELLTG 214
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 59.7 bits (143), Expect = 5e-09 Identities = 31/78 (39%), Positives = 47/78 (60%) Frame = +2 Query: 119 VIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLT 298 ++HRD+K NILI +D + ++ADFGL + + + + GT YL PE R Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGL-VRAVAAASITSTGVILGTAAYLSPEQVRDGNAD 196 Query: 299 TKSDVYSFGVVLLEILSG 352 +SDVYS GV++ E+L+G Sbjct: 197 PRSDVYSVGVLVYELLTG 214
>AVR2A_XENLA (P27039) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type II) (ACTR-II) Length = 514 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/130 (33%), Positives = 65/130 (50%), Gaps = 15/130 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH--------GYACPPVIHRDIKSSNILIDEDHNARVADFG 193 ++W IA ARG+ +LH G+ P V HRDIKS N+L+ + A +ADFG Sbjct: 285 VSWNELCLIAETMARGLSHLHEDIPGLKDGHK-PAVAHRDIKSKNVLLKNNLTACIADFG 343 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEILSG 352 L++ + GT Y+ PE + R +L + D+Y+FG+VL E+ S Sbjct: 344 LALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAFGLVLWELASR 401 Query: 353 RKAIDMQLEE 382 A D ++E Sbjct: 402 CTASDGPVDE 411
>AVR2B_PIG (Q66T47) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 18/133 (13%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH---------GYACPPVIHRDIKSSNILIDEDHNARVADF 190 + W +A +RG+ YLH G+ P + HRD KS N+L+ D A +ADF Sbjct: 282 ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHK-PSIAHRDFKSKNVLLKSDLTAVLADF 340 Query: 191 GLSIMGPVDSGTPLSEL--PAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEI 343 GL++ + G P + GT Y+ PE + R +L + D+Y+ G+VL E+ Sbjct: 341 GLAVR--FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRNAFL--RIDMYAMGLVLWEL 396 Query: 344 LSGRKAIDMQLEE 382 +S KA D ++E Sbjct: 397 VSRCKAADGPVDE 409
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 59.7 bits (143), Expect = 5e-09 Identities = 37/102 (36%), Positives = 48/102 (47%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R T + A + Y H VIHRDIK N+L+ ++ADFG S+ P T Sbjct: 232 RTATYITELANALSYCHSKR---VIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT 288 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 L GTL YL PE K D++S GV+ E L G+ Sbjct: 289 L----CGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGK 326
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 59.7 bits (143), Expect = 5e-09 Identities = 51/167 (30%), Positives = 77/167 (46%), Gaps = 13/167 (7%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSG 223 W++RV+ A A G+ YLH +IHRD+ S N L+ E+ + VADFGL+ + + Sbjct: 441 WSQRVSFAKDIAAGMAYLHSMN---IIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKN 497 Query: 224 TP--LSELP----------AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 P L L G ++ PE K D++SFG+VL EI+ GR + D Sbjct: 498 QPEHLQNLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDIFSFGIVLCEII-GRVSAD 556 Query: 368 MQLEEGNIVEWAAPLIKAG-DISGILDPALSPPSDPEALKKIAAVAC 505 ++ G ++ G L+ PP+ P + IAA C Sbjct: 557 --------PDYLPRTTDFGLNVRGFLE-RYCPPACPPSFFPIAACCC 594
>KIN15_CAEEL (P34891) Receptor-like tyrosine-protein kinase kin-15 precursor (EC| 2.7.10.1) Length = 488 Score = 59.3 bits (142), Expect = 6e-09 Identities = 40/106 (37%), Positives = 59/106 (55%), Gaps = 8/106 (7%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDS----- 220 ++ + Q A G+EYL A P +HRD+ N+L++++ R+ADFGL+ VD Sbjct: 297 LSFSYQIAEGMEYL---ASIPCVHRDLALRNVLLNKNKTIRIADFGLARKYQVDGYYRIT 353 Query: 221 ---GTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 GTP +PA ++ PE R T KSDV+S+GV L E+ S Sbjct: 354 KGVGTP---MPA---RWMAPEVMREGKCTEKSDVWSYGVSLYEMFS 393
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 59.3 bits (142), Expect = 6e-09 Identities = 36/101 (35%), Positives = 48/101 (47%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R T + A + Y H VIHRDIK N+L+ + ++ADFG S+ P T Sbjct: 223 RTATYITELANALSYCHSKR---VIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTT 279 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + GTL YL PE K D++S GV+ E L G Sbjct: 280 M----CGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVG 316
>AVR2B_RAT (P38445) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 513 Score = 59.3 bits (142), Expect = 6e-09 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 18/133 (13%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH---------GYACPPVIHRDIKSSNILIDEDHNARVADF 190 + W +A +RG+ YLH G+ P + HRD KS N+L+ D A +ADF Sbjct: 283 ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHK-PSIAHRDFKSKNVLLKSDLTAVLADF 341 Query: 191 GLSIMGPVDSGTPLSEL--PAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEI 343 GL++ + G P + GT Y+ PE + R +L + D+Y+ G+VL E+ Sbjct: 342 GLAVR--FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWEL 397 Query: 344 LSGRKAIDMQLEE 382 +S KA D ++E Sbjct: 398 VSRCKAADGPVDE 410
>RIPK5_XENTR (Q67E00) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 918 Score = 59.3 bits (142), Expect = 6e-09 Identities = 37/109 (33%), Positives = 57/109 (52%) Frame = +2 Query: 26 LKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM 205 LK L+ R+ IA+ GI +LH ++HRDIK N+L+D+ H A++ D G Sbjct: 736 LKTGLSLETRLQIALDVVEGIRFLHNQG---LVHRDIKLKNVLLDKKHRAKITDLGFCKP 792 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 793 EAMMSGSIV-----GTPIHMAPELFSGKY-DNSVDVYAFGILFWYICSG 835
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 59.3 bits (142), Expect = 6e-09 Identities = 41/117 (35%), Positives = 58/117 (49%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSEL 241 IA RG+ YLH VIHRDIK NIL++E ++ DFG+S ++ L+ Sbjct: 322 IAESVLRGLSYLHERK---VIHRDIKPQNILLNEKGEIKLCDFGVS----GEAVNSLAMT 374 Query: 242 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAAPL 412 GT Y+ PE + + DV+S G+ LLE+ GR E I + AP+ Sbjct: 375 FTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGR----FPFESDKITQNVAPI 427
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 59.3 bits (142), Expect = 6e-09 Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 4/111 (3%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L W R I + + + +LH PP++H D+K NIL+D + + +++DFGLS Sbjct: 115 LCWKLRFRIIHETSLAMNFLHSIK-PPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQS 173 Query: 218 SGTPLSELPA--GTLGYLDPEYYRLHYLT--TKSDVYSFGVVLLEILSGRK 358 + E A G L Y+ PE + K DVYSF +V+ E+L+ +K Sbjct: 174 TRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKK 224
>AVR2B_HUMAN (Q13705) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 59.3 bits (142), Expect = 6e-09 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 18/133 (13%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH---------GYACPPVIHRDIKSSNILIDEDHNARVADF 190 + W +A +RG+ YLH G+ P + HRD KS N+L+ D A +ADF Sbjct: 282 ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHK-PSIAHRDFKSKNVLLKSDLTAVLADF 340 Query: 191 GLSIMGPVDSGTPLSEL--PAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEI 343 GL++ + G P + GT Y+ PE + R +L + D+Y+ G+VL E+ Sbjct: 341 GLAVR--FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWEL 396 Query: 344 LSGRKAIDMQLEE 382 +S KA D ++E Sbjct: 397 VSRCKAADGPVDE 409
>AVR2B_BOVIN (Q95126) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 59.3 bits (142), Expect = 6e-09 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 18/133 (13%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH---------GYACPPVIHRDIKSSNILIDEDHNARVADF 190 + W +A +RG+ YLH G+ P + HRD KS N+L+ D A +ADF Sbjct: 282 ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHK-PSIAHRDFKSKNVLLKSDLTAVLADF 340 Query: 191 GLSIMGPVDSGTPLSEL--PAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEI 343 GL++ + G P + GT Y+ PE + R +L + D+Y+ G+VL E+ Sbjct: 341 GLAVR--FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWEL 396 Query: 344 LSGRKAIDMQLEE 382 +S KA D ++E Sbjct: 397 VSRCKAADGPVDE 409
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 59.3 bits (142), Expect = 6e-09 Identities = 37/115 (32%), Positives = 56/115 (48%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 LN T Q A ++Y+H ++HRDIK NILI ++ ++ DFG S+ + Sbjct: 195 LNETLASYFVYQMANALDYMHS---KNILHRDIKPENILIGFNNTIKLTDFGWSVYN--E 249 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 G L GT+ YL PE + K DV++ GV+ E+L G + +E Sbjct: 250 DGQKRKTL-CGTIDYLSPELIKSREYNNKVDVWALGVLTYELLVGSPPFEEDTKE 303
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 59.3 bits (142), Expect = 6e-09 Identities = 36/100 (36%), Positives = 53/100 (53%), Gaps = 1/100 (1%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q +++ H ++ + HRD+K N+L+DE +N R+ADFG M + G L E G Sbjct: 124 QIISALDFCHSHS---ICHRDLKPENLLLDEKNNIRIADFG---MASLQVGDSLLETSCG 177 Query: 251 TLGYLDPEYYR-LHYLTTKSDVYSFGVVLLEILSGRKAID 367 + Y PE R Y K+DV+S GV+L +L G D Sbjct: 178 SPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFD 217
>AVR2B_MOUSE (P27040) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 536 Score = 59.3 bits (142), Expect = 6e-09 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 18/133 (13%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH---------GYACPPVIHRDIKSSNILIDEDHNARVADF 190 + W +A +RG+ YLH G+ P + HRD KS N+L+ D A +ADF Sbjct: 306 ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHK-PSIAHRDFKSKNVLLKSDLTAVLADF 364 Query: 191 GLSIMGPVDSGTPLSEL--PAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEI 343 GL++ + G P + GT Y+ PE + R +L + D+Y+ G+VL E+ Sbjct: 365 GLAVR--FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWEL 420 Query: 344 LSGRKAIDMQLEE 382 +S KA D ++E Sbjct: 421 VSRCKAADGPVDE 433
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 58.9 bits (141), Expect = 8e-09 Identities = 35/106 (33%), Positives = 60/106 (56%), Gaps = 1/106 (0%) Frame = +2 Query: 41 NWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPVD 217 N+TR++ I G+ YLH +IHRDIK +NILID ++ DFG+S + P++ Sbjct: 579 NFTRQILI------GVAYLHK---KNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLN 629 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 G++ ++ PE + T K+D++S G V++E+ +G+ Sbjct: 630 KKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGK 675
>TLK1_MOUSE (Q8C0V0) Serine/threonine-protein kinase tousled-like 1 (EC| 2.7.11.1) (Tousled-like kinase 1) Length = 766 Score = 58.9 bits (141), Expect = 8e-09 Identities = 44/144 (30%), Positives = 73/144 (50%), Gaps = 11/144 (7%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDH---NARVADFGLSIMGPVDS--- 220 +I +Q + YL+ PP+IH D+K NIL+ + ++ DFGLS + DS Sbjct: 563 SIVMQIVNALRYLNEIK-PPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGV 621 Query: 221 -GTPLSELPAGTLGYLDPEYYRLHY----LTTKSDVYSFGVVLLEILSGRKAIDMQLEEG 385 G L+ AGT YL PE + + ++ K DV+S GV+ + L GRK + Sbjct: 622 DGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQ 681 Query: 386 NIVEWAAPLIKAGDISGILDPALS 457 +I++ ++KA ++ + P +S Sbjct: 682 DILQ-ENTILKATEVQFPVKPVVS 704
>TLK1_HUMAN (Q9UKI8) Serine/threonine-protein kinase tousled-like 1 (EC| 2.7.11.1) (Tousled-like kinase 1) (PKU-beta) Length = 766 Score = 58.9 bits (141), Expect = 8e-09 Identities = 44/144 (30%), Positives = 73/144 (50%), Gaps = 11/144 (7%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDH---NARVADFGLSIMGPVDS--- 220 +I +Q + YL+ PP+IH D+K NIL+ + ++ DFGLS + DS Sbjct: 563 SIVMQIVNALRYLNEIK-PPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGV 621 Query: 221 -GTPLSELPAGTLGYLDPEYYRLHY----LTTKSDVYSFGVVLLEILSGRKAIDMQLEEG 385 G L+ AGT YL PE + + ++ K DV+S GV+ + L GRK + Sbjct: 622 DGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQ 681 Query: 386 NIVEWAAPLIKAGDISGILDPALS 457 +I++ ++KA ++ + P +S Sbjct: 682 DILQ-ENTILKATEVQFPVKPVVS 704
>PKH1_YEAST (Q03407) Serine/threonine-protein kinase PKH1 (EC 2.7.11.1)| (3-phosphoinositide-dependent protein kinase 1) Length = 766 Score = 58.9 bits (141), Expect = 8e-09 Identities = 37/117 (31%), Positives = 61/117 (52%), Gaps = 11/117 (9%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 LN T A Q ++ LH +IHRDIK NIL+D++ ++ DFG + + P + Sbjct: 221 LNETCARYYASQIIDAVDSLHNIG---IIHRDIKPENILLDKNMKVKLTDFGTAKILPEE 277 Query: 218 -----SGTPLSELPA------GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 G P +L A GT Y+ PE +Y ++ D+++FG +L ++L+G+ Sbjct: 278 PSNTADGKPYFDLYAKSKSFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGK 334
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 58.9 bits (141), Expect = 8e-09 Identities = 33/108 (30%), Positives = 55/108 (50%), Gaps = 6/108 (5%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPP------VIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSG 223 + AA G+ Y H + +IHRD+ NIL+ +V DFG++ + Sbjct: 114 VVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKVVDFGIAKVAGQGHR 173 Query: 224 TPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 T L+ + G + Y+ PE + + + DVY+ GVVL E+L+G++ D Sbjct: 174 T-LTGVVKGKVAYMPPEQLQAKAMDRRVDVYALGVVLYELLTGKRPFD 220
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 58.9 bits (141), Expect = 8e-09 Identities = 36/109 (33%), Positives = 61/109 (55%), Gaps = 2/109 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM- 205 K +L + V ++ A G+ YL G C IHRD+ + N L+ E++ +++DFG+S Sbjct: 154 KDELKLKQLVRFSLDVAAGMLYLEGKNC---IHRDLAARNCLVGENNTLKISDFGMSRQE 210 Query: 206 -GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 G V S + L ++P + + PE +++SDV+SFG++L E S Sbjct: 211 DGGVYSSSGLKQIP---IKWTAPEALNYGRYSSESDVWSFGILLWETFS 256
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 58.9 bits (141), Expect = 8e-09 Identities = 32/100 (32%), Positives = 55/100 (55%) Frame = +2 Query: 68 VQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPA 247 + +A + + HG +IHRD+K N+L+ +V DFG++ S T + + Sbjct: 120 ILSAMDMAHSHG-----IIHRDLKPQNVLVSSSGTVKVTDFGIAKALSETSLTQTNTM-F 173 Query: 248 GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 G++ YL PE R T +SD+Y+ G++L E+L+G+ D Sbjct: 174 GSVHYLSPEQARGSNATVQSDIYAIGIILFELLTGQIPFD 213
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 58.9 bits (141), Expect = 8e-09 Identities = 35/98 (35%), Positives = 57/98 (58%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSEL 241 IAV + G+ YL Y +IHRD+K SNIL++ ++ DFG+S G + + +++ Sbjct: 210 IAVAVSHGLTYL--YDVHRIIHRDVKPSNILVNGAGQIKICDFGVS--GELINS--IADT 263 Query: 242 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 GT Y+ PE + + KSDV+S GV ++++ GR Sbjct: 264 FVGTSTYMSPERIQGDQYSVKSDVWSLGVSIIDVALGR 301
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 58.9 bits (141), Expect = 8e-09 Identities = 36/109 (33%), Positives = 59/109 (54%), Gaps = 1/109 (0%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMG 208 K L + ++I ++ A+ +E H +IHRD+K NIL+ E+ +V DFG I Sbjct: 102 KGALPYEVAISIGIKVAKALECAHKSG---IIHRDVKPQNILVTEEGVVKVTDFG--IAK 156 Query: 209 PVDSGT-PLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 +DS T + G+ Y PE + Y ++D+YS G+VL E+++G Sbjct: 157 SMDSSTIAHTNSVMGSAHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTG 205
>TLK1_CAEEL (P34314) Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1)| (Tousled-like kinase 1) Length = 965 Score = 58.9 bits (141), Expect = 8e-09 Identities = 44/143 (30%), Positives = 76/143 (53%), Gaps = 10/143 (6%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNA---RVADFGLSIMGPVDS--- 220 +I +Q + YL+ + P +IH D+K +NIL++ + + ++ DFGLS + +S Sbjct: 758 SIIMQVVSALVYLNEKSTP-IIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDH 816 Query: 221 --GTPLSELPAGTLGYLDPEYYRLH--YLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGN 388 G L+ AGT YL PE + + +T K DV+S GV+ + + G+K L + Sbjct: 817 DLGIELTSQFAGTYWYLPPETFIVPPPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQK 876 Query: 389 IVEWAAPLIKAGDISGILDPALS 457 I+E+ +I A ++S P +S Sbjct: 877 ILEYNT-IINAREVSFPSKPQVS 898
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 58.5 bits (140), Expect = 1e-08 Identities = 38/99 (38%), Positives = 57/99 (57%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 A+ A G+EYL ++HRD+ + NIL+ ED A+V+DFGL+ G S LP Sbjct: 331 ALHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLA--KAERKGLDSSRLP 385 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKA 361 + + PE + ++KSDV+SFGV+L E+ S +A Sbjct: 386 ---VKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRA 421
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 58.5 bits (140), Expect = 1e-08 Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 5/110 (4%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPV 214 +++ T++V +A Q A G+ YL IHRD+ + N+L+ E + +VADFGL+ + V Sbjct: 325 KIHLTQQVDMAAQVASGMAYLESRN---YIHRDLAARNVLVGEHNIYKVADFGLARVFKV 381 Query: 215 DSGTPLS-----ELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 D+ +LP + + PE R + + KSDV+SFG++L EI++ Sbjct: 382 DNEDIYESRHEIKLP---VKWTAPEAIRSNKFSIKSDVWSFGILLYEIIT 428
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 58.5 bits (140), Expect = 1e-08 Identities = 34/98 (34%), Positives = 55/98 (56%), Gaps = 2/98 (2%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSE--LP 244 QAA G+ +H ++HRDIK N+LI + ++ DFG++ + PL+ + Sbjct: 131 QAAHGLSVIHRM---DMVHRDIKPGNMLITANGIVKITDFGIA---KAAAAVPLTRTGMV 184 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRK 358 GT Y+ PE + +T SD+YS GVV E+++GR+ Sbjct: 185 VGTAQYVSPEQAQGKEVTAASDIYSLGVVGYEMMAGRR 222
>YS3J_CAEEL (Q19238) Putative tyrosine-protein kinase F09A5.2 in chromosome X| (EC 2.7.10.1) Length = 894 Score = 58.5 bits (140), Expect = 1e-08 Identities = 38/98 (38%), Positives = 58/98 (59%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 V+IA Q A G+ YL A IHRD+ + NIL+ + A+V+DFGL +DS + Sbjct: 631 VSIAWQVADGMSYL---ASKNFIHRDLAARNILLTKSLTAKVSDFGLCRY--MDSALYTA 685 Query: 236 ELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + + ++ E +L+ +TK+DV+SFGV+L EI S Sbjct: 686 KGGRLPIKWMSVEALKLYEFSTKTDVWSFGVLLFEIFS 723
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 58.5 bits (140), Expect = 1e-08 Identities = 36/95 (37%), Positives = 47/95 (49%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A + Y H VIHRDIK N+L+ + ++ADFG S+ P T L G Sbjct: 246 QLAEALLYCHS---KKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTL----CG 298 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 TL YL PE K D++S GV+ E L G+ Sbjct: 299 TLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGK 333
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 58.5 bits (140), Expect = 1e-08 Identities = 36/104 (34%), Positives = 53/104 (50%), Gaps = 1/104 (0%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+EYLH + HRDIK N+L+DE +++DFGL+ + + L G Sbjct: 113 QLIAGVEYLHSIG---ITHRDIKPENLLLDERDQLKISDFGLATVFRHNGKERLLNKMCG 169 Query: 251 TLGYLDPEYYRLH-YLTTKSDVYSFGVVLLEILSGRKAIDMQLE 379 TL Y+ PE + + DV+S G+VL +L+G D E Sbjct: 170 TLPYVAPELIKSRAFHADPVDVWSCGIVLTAMLAGELPWDQPNE 213
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 58.5 bits (140), Expect = 1e-08 Identities = 33/94 (35%), Positives = 50/94 (53%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q + + YLHG +IHRDIK NIL+ + +++DFG S+ P + + L G Sbjct: 205 QMSEALLYLHG---KNIIHRDIKPENILLHFNDTIKISDFGWSVHAPSNRRSTL----CG 257 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T+ YL PE + DV+S G+++ E L G Sbjct: 258 TMDYLPPEIVQSRPYDKNVDVWSLGILMYEFLCG 291
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 58.5 bits (140), Expect = 1e-08 Identities = 35/104 (33%), Positives = 56/104 (53%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A ++Y+H ++HRDIK NI+I ++ ++ DFG S++ P G+ L G Sbjct: 215 QMADALDYMHERN---ILHRDIKPENIIIGFNNTIKLTDFGWSVITP--KGSKRKTL-CG 268 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 T+ YL PE R K DV++ GV+ E+L G + + +E Sbjct: 269 TVDYLSPELIRSREYNEKVDVWALGVLTYELLVGSPPFEEESKE 312
>RK_RAT (Q63651) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 58.5 bits (140), Expect = 1e-08 Identities = 32/102 (31%), Positives = 55/102 (53%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R + Q G+E+LH +++RD+K N+L+D D N R++D GL++ + G Sbjct: 293 RAIYYTAQIISGLEHLHQRR---IVYRDLKPENVLLDNDGNIRISDLGLAV--ELKEGQN 347 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 ++ AGT G++ PE R D ++ GV L E+++ R Sbjct: 348 KTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAAR 389
>RK_MOUSE (Q9WVL4) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 58.5 bits (140), Expect = 1e-08 Identities = 32/102 (31%), Positives = 55/102 (53%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R + Q G+E+LH +++RD+K N+L+D D N R++D GL++ + G Sbjct: 293 RAIYYTAQIISGLEHLHQRR---IVYRDLKPENVLLDNDGNIRISDLGLAV--ELKEGQN 347 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 ++ AGT G++ PE R D ++ GV L E+++ R Sbjct: 348 KTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAAR 389
>TAOK3_PONPY (Q5R4F3) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 58.5 bits (140), Expect = 1e-08 Identities = 43/127 (33%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +2 Query: 5 CMARXSNL----KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHN 172 C+ S+L KK L I A G+ YLH +A +IHRDIK+ NIL+ E Sbjct: 104 CLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHA---LIHRDIKAGNILLTEPGQ 160 Query: 173 ARVADFG-LSIMGPVDS--GTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEI 343 ++ADFG S+ P +S GTP P L + +Y K DV+S G+ +E+ Sbjct: 161 VKLADFGSASVASPANSFVGTPYWMAPEVILAMDEGQY------DGKVDVWSLGITCIEL 214 Query: 344 LSGRKAI 364 + A+ Sbjct: 215 AERKPAL 221
>JAK3_MOUSE (Q62137) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1299 Score = 58.5 bits (140), Expect = 1e-08 Identities = 34/105 (32%), Positives = 59/105 (56%), Gaps = 1/105 (0%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVD 217 L+ R + A Q +G+EYL C +HRD+ + NIL++ + + ++ADFGL+ + P+ Sbjct: 1130 LHTDRLLLFAWQICKGMEYLGARRC---VHRDLAARNILVESEAHVKIADFGLAKLLPLG 1186 Query: 218 SGTPLSELPA-GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + P + + PE + + +SDV+SFGVVL E+ + Sbjct: 1187 KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT 1231
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) Length = 800 Score = 58.2 bits (139), Expect = 1e-08 Identities = 39/107 (36%), Positives = 61/107 (57%), Gaps = 3/107 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI-MGPV 214 L++ V+ A Q ARG++YL C IHRD+ + N+L+ ED ++ADFGL+ + + Sbjct: 582 LSFPALVSCAYQVARGMQYLESRKC---IHRDLAARNVLVTEDDVMKIADFGLARGVHHI 638 Query: 215 D--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 D T LP + ++ PE T +SDV+SFG++L EI + Sbjct: 639 DYYKKTSNGRLP---VKWMAPEALFDRVYTHQSDVWSFGILLWEIFT 682
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 58.2 bits (139), Expect = 1e-08 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+ YLH + HRD+K N+L+DE N +++DFGL+ + + L G Sbjct: 113 QLIAGVVYLHSMG---ITHRDLKPENLLLDERDNLKISDFGLATVFKHNGRERLLNKMCG 169 Query: 251 TLGYLDPEYYRL-HYLTTKSDVYSFGVVLLEILSG 352 TL Y+ PE R + DV++ GVVL +L+G Sbjct: 170 TLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAG 204
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 58.2 bits (139), Expect = 1e-08 Identities = 33/94 (35%), Positives = 53/94 (56%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 + A +++LHG +I+RD+K NIL+DE+ + ++ DFGLS S G Sbjct: 167 ELALALDHLHGLG---IIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSF--CG 221 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T+ Y+ PE T +D +SFGV++ E+L+G Sbjct: 222 TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 255 Score = 50.4 bits (119), Expect = 3e-06 Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 4/96 (4%) Frame = +2 Query: 77 ARGIEYLHGYACPPVIHRDIKSSNIL-IDEDHN---ARVADFGLSIMGPVDSGTPLSELP 244 AR ++YLH V+HRD+K SNIL +DE N R+ DFG + ++G L P Sbjct: 517 ARTMDYLHSQG---VVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENG--LLMTP 571 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T ++ PE + DV+S G++L +L+G Sbjct: 572 CYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAG 607
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 58.2 bits (139), Expect = 1e-08 Identities = 33/102 (32%), Positives = 56/102 (54%) Frame = +2 Query: 47 TRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGT 226 TR T + +A +EYLHG +IHRD+K NIL++ED + ++ DFG + + DS Sbjct: 185 TRFYTAEIVSA--LEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPDSKQ 239 Query: 227 PLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + GT Y+ PE SD+++ G ++ ++++G Sbjct: 240 ARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAG 281
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 15/130 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH--------GYACPPVIHRDIKSSNILIDEDHNARVADFG 193 ++W IA ARG+ YLH G+ P + HRDIKS N+L+ + A +ADFG Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHK-PAISHRDIKSKNVLLKNNLTACIADFG 342 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEILSG 352 L++ + GT Y+ PE + R +L + D+Y+ G+VL E+ S Sbjct: 343 LALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWELASR 400 Query: 353 RKAIDMQLEE 382 A D ++E Sbjct: 401 CTAADGPVDE 410
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 15/130 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH--------GYACPPVIHRDIKSSNILIDEDHNARVADFG 193 ++W IA ARG+ YLH G+ P + HRDIKS N+L+ + A +ADFG Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHK-PAISHRDIKSKNVLLKNNLTACIADFG 342 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEILSG 352 L++ + GT Y+ PE + R +L + D+Y+ G+VL E+ S Sbjct: 343 LALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWELASR 400 Query: 353 RKAIDMQLEE 382 A D ++E Sbjct: 401 CTAADGPVDE 410
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 15/130 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH--------GYACPPVIHRDIKSSNILIDEDHNARVADFG 193 ++W IA ARG+ YLH G+ P + HRDIKS N+L+ + A +ADFG Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHK-PAISHRDIKSKNVLLKNNLTACIADFG 342 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEILSG 352 L++ + GT Y+ PE + R +L + D+Y+ G+VL E+ S Sbjct: 343 LALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWELASR 400 Query: 353 RKAIDMQLEE 382 A D ++E Sbjct: 401 CTAADGPVDE 410
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 15/130 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH--------GYACPPVIHRDIKSSNILIDEDHNARVADFG 193 ++W IA ARG+ YLH G+ P + HRDIKS N+L+ + A +ADFG Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHK-PAISHRDIKSKNVLLKNNLTACIADFG 342 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEILSG 352 L++ + GT Y+ PE + R +L + D+Y+ G+VL E+ S Sbjct: 343 LALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWELASR 400 Query: 353 RKAIDMQLEE 382 A D ++E Sbjct: 401 CTAADGPVDE 410
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/95 (38%), Positives = 55/95 (57%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 A ARG++YL + IHRD+ + NIL+ E++ A++ADFGLS V + LP Sbjct: 946 AADVARGMDYL---SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLP 1002 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + ++ E TT SDV+S+GV+L EI+S Sbjct: 1003 ---VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 1034
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 58.2 bits (139), Expect = 1e-08 Identities = 39/110 (35%), Positives = 58/110 (52%), Gaps = 6/110 (5%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI---DEDHNARVADFGLSIMG 208 L+W R+ +A+ A+G+ YLH V HRD+ S N L+ D A V DFGL+ Sbjct: 142 LSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKI 198 Query: 209 PVDSGTPLSELPAGTLG---YLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 PV E P +G ++ PE R K+DV++FG+VL E+++ Sbjct: 199 PVYREGARKE-PLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 247
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (CD334 antigen) Length = 802 Score = 58.2 bits (139), Expect = 1e-08 Identities = 38/101 (37%), Positives = 59/101 (58%), Gaps = 3/101 (2%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI-MGPVD--SGT 226 V+ A Q ARG++YL C IHRD+ + N+L+ ED+ ++ADFGL+ + +D T Sbjct: 590 VSCAYQVARGMQYLESRKC---IHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT 646 Query: 227 PLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 LP + ++ PE T +SDV+SFG++L EI + Sbjct: 647 SNGRLP---VKWMAPEALFDRVYTHQSDVWSFGILLWEIFT 684
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 58.2 bits (139), Expect = 1e-08 Identities = 34/100 (34%), Positives = 53/100 (53%), Gaps = 1/100 (1%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q +++ H Y+ + HRD+K N+L+DE +N R+ADFG M + G L E G Sbjct: 155 QIVSALDFCHSYS---ICHRDLKPENLLLDEKNNIRIADFG---MASLQVGDSLLETSCG 208 Query: 251 TLGYLDPEYYR-LHYLTTKSDVYSFGVVLLEILSGRKAID 367 + Y PE + Y ++D++S GV+L +L G D Sbjct: 209 SPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFD 248
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 58.2 bits (139), Expect = 1e-08 Identities = 34/105 (32%), Positives = 60/105 (57%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPV 214 +L+ R + ++ Q A G+ Y+ IHRD++++NIL+ E ++ADFGL+ + + Sbjct: 330 RLSLPRLIDMSAQIAEGMAYIERMNS---IHRDLRAANILVSEALCCKIADFGLARI--I 384 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 DS E + + PE T K+DV+SFGV+L+E+++ Sbjct: 385 DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVT 429
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/113 (35%), Positives = 60/113 (53%) Frame = +2 Query: 11 ARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADF 190 AR L+ + + A AA G++YL IHRD+ + N+L+ E+ +++ADF Sbjct: 940 AREHGTASTLSSRQLLRFASDAANGMQYLSE---KQFIHRDLAARNVLVGENLASKIADF 996 Query: 191 GLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 GLS V + LP + ++ E TTKSDV+SFGV+L EI+S Sbjct: 997 GLSRGEEVYVKKTMGRLP---VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS 1046
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 8/106 (7%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSEL 241 + Q RG++Y+H VIHRD+K SNI ++ED R+ DFGL+ P +S Sbjct: 133 LVYQILRGLKYIHSAG---VIHRDLKPSNIAVNEDCELRILDFGLA--RPAES------- 180 Query: 242 PAGTLGYLDPEYYR--------LHYLTTKSDVYSFGVVLLEILSGR 355 GY+ +YR +HY T +D++S G ++ E+L+GR Sbjct: 181 --EMTGYVATRWYRAPEIMLNWMHYNQT-ADIWSVGCIMAELLTGR 223
>RIPK5_CHICK (Q6XUX0) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/111 (33%), Positives = 57/111 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L R+ IA+ GI YLH ++HRDIK N+L+D+ + A++ D G Sbjct: 744 TGLKAGLELETRLQIALDVVEGIRYLHSQG---LVHRDIKLKNVLLDKKNRAKITDLGFC 800 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 801 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYICSG 845
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/95 (38%), Positives = 55/95 (57%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 A ARG++YL + IHRD+ + NIL+ E++ A++ADFGLS V + LP Sbjct: 943 AADVARGMDYL---SQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLP 999 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + ++ E TT SDV+S+GV+L EI+S Sbjct: 1000 ---VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 1031
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/95 (38%), Positives = 55/95 (57%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 A ARG++YL + IHRD+ + NIL+ E++ A++ADFGLS V + LP Sbjct: 945 AADVARGMDYL---SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLP 1001 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + ++ E TT SDV+S+GV+L EI+S Sbjct: 1002 ---VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 1033
>RK_BOVIN (P28327) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 561 Score = 58.2 bits (139), Expect = 1e-08 Identities = 32/102 (31%), Positives = 56/102 (54%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R + Q G+E+LH +I+RD+K N+L+D+D N R++D GL++ + +G Sbjct: 290 RAIFYTAQIVSGLEHLHQRN---IIYRDLKPENVLLDDDGNVRISDLGLAV--ELKAGQT 344 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 ++ AGT G++ PE D ++ GV L E+++ R Sbjct: 345 KTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAAR 386
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) Length = 812 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/107 (37%), Positives = 62/107 (57%), Gaps = 3/107 (2%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMGPV 214 L++ V+ A Q ARG++YL C IHRD+ + N+L+ ED+ ++ADFGL+ + + Sbjct: 589 LSFKDLVSCAYQVARGMDYLASKKC---IHRDLAARNVLVTEDNIMKIADFGLARDIHHI 645 Query: 215 D--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 D T LP + ++ PE T +SDV+SFGV+L EI + Sbjct: 646 DYYKKTTNGRLP---VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 689
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/113 (35%), Positives = 60/113 (53%) Frame = +2 Query: 11 ARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADF 190 AR L+ + + A AA G++YL IHRD+ + N+L+ E+ +++ADF Sbjct: 942 AREHGTASTLSSRQLLRFASDAANGMQYLSE---KQFIHRDLAARNVLVGENLASKIADF 998 Query: 191 GLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 GLS V + LP + ++ E TTKSDV+SFGV+L EI+S Sbjct: 999 GLSRGEEVYVKKTMGRLP---VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS 1048
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/113 (35%), Positives = 60/113 (53%) Frame = +2 Query: 11 ARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADF 190 AR L+ + + A AA G++YL IHRD+ + N+L+ E+ +++ADF Sbjct: 938 AREHGTASTLSSRQLLRFASDAANGMQYLSE---KQFIHRDLAARNVLVGENLASKIADF 994 Query: 191 GLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 GLS V + LP + ++ E TTKSDV+SFGV+L EI+S Sbjct: 995 GLSRGEEVYVKKTMGRLP---VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS 1044
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 57.8 bits (138), Expect = 2e-08 Identities = 34/100 (34%), Positives = 59/100 (59%), Gaps = 2/100 (2%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS 235 + A Q ARG++YL C IHRD+ + N+L+ +D+ ++ADFGL+ + S Sbjct: 534 IKFAHQIARGMDYLASRRC---IHRDLAARNVLVSDDYVLKIADFGLA--RDIQSTDYYR 588 Query: 236 ELPAGTL--GYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + G L ++ PE + + +KSDV+S+G++L EI++ Sbjct: 589 KNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMT 628
>AMHR2_RAT (Q62893) Anti-Muellerian hormone type-2 receptor precursor (EC| 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII) (C14) Length = 557 Score = 57.8 bits (138), Expect = 2e-08 Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 23/126 (18%) Frame = +2 Query: 41 NWTRRVTIAVQAARGIEYLHGYAC------PPVIHRDIKSSNILIDEDHNARVADFGLSI 202 +W + +A+ A G+ +LHG P + HRD+ S N+LI ED + + D GL++ Sbjct: 295 DWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLAL 354 Query: 203 ----------MGPVDSGTPLSELPAGTLGYLDPEYYRLHY-------LTTKSDVYSFGVV 331 + P P + L AGT Y+ PE ++DVYS ++ Sbjct: 355 VLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALL 414 Query: 332 LLEILS 349 L EILS Sbjct: 415 LWEILS 420
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 57.8 bits (138), Expect = 2e-08 Identities = 36/101 (35%), Positives = 47/101 (46%) Frame = +2 Query: 50 RRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTP 229 R T + A + Y H VIHRDIK N+L+ + ++ADFG S+ P T Sbjct: 225 RTATYITELANALSYCHSKR---VIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTT 281 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 L GTL Y PE K D++S GV+ E L G Sbjct: 282 L----CGTLDYQPPEMIEGRMHDEKVDLWSLGVLCYEFLVG 318
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 57.8 bits (138), Expect = 2e-08 Identities = 47/166 (28%), Positives = 79/166 (47%), Gaps = 9/166 (5%) Frame = +2 Query: 2 ICMARXS--NLKKQLNWTRRVT------IAVQAARGIEYLHGYACPPVIHRDIKSSNILI 157 ICM +L + L RR+ +++ RG+ YL ++HRD+K SNIL+ Sbjct: 142 ICMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLVYLREKH--QIMHRDVKPSNILV 199 Query: 158 DEDHNARVADFGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLL 337 + ++ DFG+S +DS ++ GT Y+ PE + + + +SDV+S G+ L+ Sbjct: 200 NSRGEIKLCDFGVSGQ-LIDS---MANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLV 255 Query: 338 EILSGRKAIDMQLEEGNIVEWAAPLIKAGDISG-ILDPALSPPSDP 472 E+ GR I + + P++ G G + P PP P Sbjct: 256 ELAIGRFPIPPPDAKELEAIFGRPVLDKGGAEGHSMSPRQRPPGRP 301
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 57.8 bits (138), Expect = 2e-08 Identities = 36/116 (31%), Positives = 59/116 (50%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A ++Y+H +IHRDIK NILI ++ ++ DFG SI+ P ++ + G Sbjct: 210 QIANALDYMHK---KNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPEN---RRKTVCG 263 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAAPLIK 418 T+ YL PE D ++ GV+ E+L+G + ++++ AA IK Sbjct: 264 TIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIK 319
>TGFR2_HUMAN (P37173) TGF-beta receptor type-2 precursor (EC 2.7.11.30)| (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) Length = 567 Score = 57.8 bits (138), Expect = 2e-08 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 14/123 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACP------PVIHRDIKSSNILIDEDHNARVADFGLS 199 ++W + ARGI +LH P P++HRD+KSSNIL+ D + DFGLS Sbjct: 342 ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLS 401 Query: 200 I-MGPVDSGTPLSEL-PAGTLGYLDPEYY--RLHYLTTKS----DVYSFGVVLLEILSGR 355 + + P S L+ GT Y+ PE R++ +S DVYS +VL E+ S Sbjct: 402 LRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENAESFKQTDVYSMALVLWEMTSRC 461 Query: 356 KAI 364 A+ Sbjct: 462 NAV 464
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 57.8 bits (138), Expect = 2e-08 Identities = 34/95 (35%), Positives = 50/95 (52%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A ++YLH +IHRDIK NIL+ D+ +++DFG S+ S T + G Sbjct: 254 QVALALDYLH---TKHIIHRDIKPENILLSTDNCIKLSDFGWSVKSLPSSSTKRLTI-CG 309 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 TL YL PE + D++S G++ E L G+ Sbjct: 310 TLDYLPPEMIESNEHDYTVDIWSLGILCYEFLVGK 344
>TGFR2_MOUSE (Q62312) TGF-beta receptor type-2 precursor (EC 2.7.11.30)| (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) Length = 592 Score = 57.8 bits (138), Expect = 2e-08 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 14/123 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACP------PVIHRDIKSSNILIDEDHNARVADFGLS 199 ++W + ARGI +LH P P++HRD+KSSNIL+ D + DFGLS Sbjct: 367 ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLS 426 Query: 200 I-MGPVDSGTPLSEL-PAGTLGYLDPEYY--RLHYLTTKS----DVYSFGVVLLEILSGR 355 + + P S L+ GT Y+ PE R++ +S DVYS +VL E+ S Sbjct: 427 LRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRC 486 Query: 356 KAI 364 A+ Sbjct: 487 NAV 489
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 57.4 bits (137), Expect = 2e-08 Identities = 38/110 (34%), Positives = 63/110 (57%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++Q+ + V+ Q ARG+EYL C IHRD+ + N+L+ E++ ++ADFGL+ + Sbjct: 595 EEQMTFKDLVSCTYQLARGMEYLASQKC---IHRDLAARNVLVTENNVMKIADFGLARDI 651 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV++ EI + Sbjct: 652 NNIDYYKKTTNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 57.4 bits (137), Expect = 2e-08 Identities = 38/110 (34%), Positives = 63/110 (57%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++Q+ + V+ Q ARG+EYL C IHRD+ + N+L+ E++ ++ADFGL+ + Sbjct: 595 EEQMTFKDLVSCTYQLARGMEYLASQKC---IHRDLAARNVLVTENNVMKIADFGLARDI 651 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV++ EI + Sbjct: 652 NNIDYYKKTTNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
>VGFR1_RAT (P53767) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) Length = 1336 Score = 57.4 bits (137), Expect = 2e-08 Identities = 39/110 (35%), Positives = 60/110 (54%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS--- 199 K+ L ++ + Q ARG+E+L C IHRD+ + NIL+ E++ ++ DFGL+ Sbjct: 991 KQPLTMEDLISYSFQVARGMEFLSSRKC---IHRDLAARNILLSENNVVKICDFGLARDI 1047 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P + LP L ++ PE +TKSDV+S+GV+L EI S Sbjct: 1048 YKNPDYVRRGDTRLP---LKWMAPESIFDKVYSTKSDVWSYGVLLWEIFS 1094
>TLK2_HUMAN (Q86UE8) Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1)| (Tousled-like kinase 2) (PKU-alpha) Length = 772 Score = 57.4 bits (137), Expect = 2e-08 Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 12/146 (8%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDED---HNARVADFGLSIMGPVDS--- 220 +I +Q ++YL+ PP+IH D+K NIL+ ++ DFGLS + DS Sbjct: 569 SIIMQIVNALKYLNEIK-PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNS 627 Query: 221 --GTPLSELPAGTLGYLDPEYYRL----HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 G L+ AGT YL PE + + ++ K DV+S GV+ + L GRK + Sbjct: 628 VDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQ 687 Query: 383 GNIVEWAAPLIKAGDISGILDPALSP 460 +I++ ++KA ++ P ++P Sbjct: 688 QDILQ-ENTILKATEVQFPPKPVVTP 712
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 57.4 bits (137), Expect = 2e-08 Identities = 34/80 (42%), Positives = 46/80 (57%), Gaps = 1/80 (1%) Frame = +2 Query: 119 VIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPL-SELPAGTLGYLDPEYYRLHYL 295 +IHRDIK NI+I E +V DFG++ + T S+ GT YL PE R + Sbjct: 142 IIHRDIKPGNIMISEQGVVKVMDFGIARALDDSAATMTQSQGVVGTAQYLSPEQARGETV 201 Query: 296 TTKSDVYSFGVVLLEILSGR 355 +SD+YS G VL E+L+GR Sbjct: 202 DMRSDLYSAGCVLYEMLTGR 221
>VGFR1_MOUSE (P35969) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) Length = 1333 Score = 57.4 bits (137), Expect = 2e-08 Identities = 39/110 (35%), Positives = 60/110 (54%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS--- 199 K+ L ++ + Q ARG+E+L C IHRD+ + NIL+ E++ ++ DFGL+ Sbjct: 991 KQPLTMEDLISYSFQVARGMEFLSSRKC---IHRDLAARNILLSENNVVKICDFGLARDI 1047 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P + LP L ++ PE +TKSDV+S+GV+L EI S Sbjct: 1048 YKNPDYVRRGDTRLP---LKWMAPESIFDKVYSTKSDVWSYGVLLWEIFS 1094
>AVR2A_RAT (P38444) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 57.4 bits (137), Expect = 2e-08 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 15/130 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH--------GYACPPVIHRDIKSSNILIDEDHNARVADFG 193 ++W IA ARG+ YLH G+ P + HRDIKS N+L+ + A +ADFG Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHK-PAISHRDIKSKNVLLKNNLTACIADFG 342 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEILSG 352 L++ + GT Y+ PE + R +L + D+Y+ G+VL E+ S Sbjct: 343 LALKFEAGKSGGDTHGQVGTRRYMAPEVLEGAINFQRDAFL--RIDMYAMGLVLWELASR 400 Query: 353 RKAIDMQLEE 382 A D ++E Sbjct: 401 CTAADGPVDE 410
>TLK2_MOUSE (O55047) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) Length = 718 Score = 57.4 bits (137), Expect = 2e-08 Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 12/146 (8%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDED---HNARVADFGLSIMGPVDS--- 220 +I +Q ++YL+ PP+IH D+K NIL+ ++ DFGLS + DS Sbjct: 515 SIIMQIVNALKYLNEIK-PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNS 573 Query: 221 --GTPLSELPAGTLGYLDPEYYRL----HYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 G L+ AGT YL PE + + ++ K DV+S GV+ + L GRK + Sbjct: 574 VDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQ 633 Query: 383 GNIVEWAAPLIKAGDISGILDPALSP 460 +I++ ++KA ++ P ++P Sbjct: 634 QDILQ-ENTILKATEVQFPPKPVVTP 658
>AVR2B_XENLA (P27041) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 511 Score = 57.4 bits (137), Expect = 2e-08 Identities = 44/133 (33%), Positives = 66/133 (49%), Gaps = 18/133 (13%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLH---------GYACPPVIHRDIKSSNILIDEDHNARVADF 190 ++W I ARG+ YLH G+ P + HRD KS N+L+ D A +ADF Sbjct: 281 VSWNELCHITETMARGLAYLHEDVPRCKGEGHK-PAIAHRDFKSKNVLLRNDLTAILADF 339 Query: 191 GLSIMGPVDSGTPLSEL--PAGTLGYLDPE-------YYRLHYLTTKSDVYSFGVVLLEI 343 GL++ + G P + GT Y+ PE + R +L + D+Y+ G+VL EI Sbjct: 340 GLAVR--FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDSFL--RIDMYAMGLVLWEI 395 Query: 344 LSGRKAIDMQLEE 382 +S A D ++E Sbjct: 396 VSRCTAADGPVDE 408
>RIPK5_RAT (Q6XUX2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 57.4 bits (137), Expect = 2e-08 Identities = 36/111 (32%), Positives = 58/111 (52%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L+ R+ IA+ GI +LH ++HRDIK N+L+D+ + A++ D G Sbjct: 741 TGLKAGLSLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFC 797 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 798 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYICSG 842
>PKN3_MYXXA (Q9XBQ0) Serine/threonine-protein kinase pkn3 (EC 2.7.11.1)| Length = 547 Score = 57.4 bits (137), Expect = 2e-08 Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 7/112 (6%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHN----ARVADFGLS-I 202 LN R V I Q + HG VIHRD+K NI+++ N +V DFG++ I Sbjct: 114 LNEGRVVRIVSQVLSALSDAHGAG---VIHRDLKPENIMVEPRRNEPDFVKVLDFGIAKI 170 Query: 203 MGPVDSGTPLSE--LPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 D G L+ GT Y+ PE R L +SD+Y+ GV+L ++++G Sbjct: 171 TDSTDDGPALTRAGFVCGTPEYMSPEQARGSQLDHRSDLYAVGVILYQLMTG 222
>TGFR2_RAT (P38438) TGF-beta receptor type-2 precursor (EC 2.7.11.30)| (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor) Length = 567 Score = 57.4 bits (137), Expect = 2e-08 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 14/123 (11%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACP------PVIHRDIKSSNILIDEDHNARVADFGLS 199 ++W + ARGI +LH P P++HRD+KSSNIL+ D + DFGLS Sbjct: 342 ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLS 401 Query: 200 I-MGPVDSGTPLSEL-PAGTLGYLDPEYY--RLHYLTTKS----DVYSFGVVLLEILSGR 355 + + P S L+ GT Y+ PE R++ +S DVYS +VL E+ S Sbjct: 402 LRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRC 461 Query: 356 KAI 364 A+ Sbjct: 462 NAV 464
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 57.4 bits (137), Expect = 2e-08 Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 1/115 (0%) Frame = +2 Query: 14 RXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFG 193 R S K+ + R+ I Q RG++Y+H V+HRD+K NI ++ + R+ DFG Sbjct: 112 RYSRSKRMSDQEIRI-ILYQILRGLKYIHSAG---VVHRDLKPCNIAVNGNSEVRILDFG 167 Query: 194 LSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKS-DVYSFGVVLLEILSGR 355 LS M D T GT+ YL PE L TK+ DV+S G +L E+++ R Sbjct: 168 LSRM-CADKMTD----HVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITDR 217
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 57.4 bits (137), Expect = 2e-08 Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 12/102 (11%) Frame = +2 Query: 86 IEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGL-----SIMGPVDSGTPLSELP-- 244 I+Y+HG VIHRD+K NIL+D++ ++ DFG S G + T ++ P Sbjct: 211 IDYMHGRG---VIHRDLKPENILLDDNMRTKITDFGSAKILNSSHGSHEEDTHHADKPQA 267 Query: 245 -----AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 GT Y+ PE T SD+++FG +L ++L+G+ Sbjct: 268 HSRSFVGTARYVSPEVLSDKIAGTASDIWAFGCILFQMLAGK 309
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 57.4 bits (137), Expect = 2e-08 Identities = 38/110 (34%), Positives = 63/110 (57%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IM 205 ++Q+ + V+ Q ARG+EYL C IHRD+ + N+L+ E++ ++ADFGL+ + Sbjct: 597 EEQMTFKDLVSCTYQLARGMEYLASQKC---IHRDLAARNVLVTENNVMKIADFGLARDI 653 Query: 206 GPVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV++ EI + Sbjct: 654 NNIDYYKKTTNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 700
>RIPK5_CANFA (Q4VSN4) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 931 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/111 (32%), Positives = 57/111 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L R+ IA+ GI +LH ++HRDIK N+L+D+ + A++ D G Sbjct: 745 TGLKAGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFC 801 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 802 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYICSG 846
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/109 (33%), Positives = 61/109 (55%), Gaps = 2/109 (1%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIM- 205 K +L + V ++ AA G+ YL C IHRD+ + N L+ E++ +++DFG+S Sbjct: 653 KDELKLKQLVKFSLDAAAGMLYLESKNC---IHRDLAARNCLVGENNVLKISDFGMSRQE 709 Query: 206 -GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 G V S + L ++P + + PE +++SDV+SFG++L E S Sbjct: 710 DGGVYSSSGLKQIP---IKWTAPEALNYGRYSSESDVWSFGILLWETFS 755
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 57.0 bits (136), Expect = 3e-08 Identities = 37/106 (34%), Positives = 59/106 (55%) Frame = +2 Query: 32 KQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGP 211 K + + V ++ Q A G+ YL ++ IHRD+ + NIL+ E + +VADFGL+ + Sbjct: 156 KNITLHQMVDMSAQIASGMTYLEAHS---YIHRDLAARNILVGEGNVCKVADFGLARVIK 212 Query: 212 VDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 D P E + + PE + T KSDV+SFGV++ EI++ Sbjct: 213 EDIYNP-REGTKFPIKWTAPEAALYNRFTIKSDVWSFGVLISEIVT 257
>RIPK5_HUMAN (Q6XUX3) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) Length = 929 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/111 (32%), Positives = 57/111 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L R+ IA+ GI +LH ++HRDIK N+L+D+ + A++ D G Sbjct: 743 TGLKAGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFC 799 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 800 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYICSG 844
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/108 (33%), Positives = 59/108 (54%), Gaps = 2/108 (1%) Frame = +2 Query: 32 KQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS--IM 205 K L+ + A Q A G+ YL V+HRD+ + N+L+ +D +VADFGL+ + Sbjct: 324 KALSLPHLLGFACQVAEGMSYLEERR---VVHRDLAARNVLVGDDLTCKVADFGLARLLK 380 Query: 206 GPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 V S + S++P + + PE + KSDV+SFG++L E+ + Sbjct: 381 DDVYSPSSGSKIP---VKWTAPEAANYRVFSQKSDVWSFGILLYEVFT 425
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 57.0 bits (136), Expect = 3e-08 Identities = 38/109 (34%), Positives = 62/109 (56%), Gaps = 3/109 (2%) Frame = +2 Query: 32 KQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS-IMG 208 +Q+ + V+ Q ARG+EYL C IHRD+ + N+L+ E++ ++ADFGL+ + Sbjct: 586 EQMTFKDLVSCTYQIARGMEYLASQKC---IHRDLAARNVLVTENNVMKIADFGLARDVN 642 Query: 209 PVD--SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 +D T LP + ++ PE T +SDV+SFGV++ EI + Sbjct: 643 NIDYYKKTSNGRLP---VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 688
>RIPK5_PANTR (Q4VSN5) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/111 (32%), Positives = 57/111 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L R+ IA+ GI +LH ++HRDIK N+L+D+ + A++ D G Sbjct: 744 TGLKAGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFC 800 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 801 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYICSG 845
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 57.0 bits (136), Expect = 3e-08 Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 16/159 (10%) Frame = +2 Query: 62 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSI------------- 202 I ++ G+ YLHG VIH+D+K NIL+D D + ++AD GL+ Sbjct: 118 IILEIIEGMCYLHGKG---VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHN 174 Query: 203 -MGPVDSGTPLSELPAGTLGYLDPEYYR--LHYLTTKSDVYSFGVVLLEILSGRKAIDMQ 373 + VD GT ++ GTL Y+ PE+ T KSDVYSF VVL I + ++ + Sbjct: 175 ELREVD-GT--AKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENA 231 Query: 374 LEEGNIVEWAAPLIKAGDISGILDPALSPPSDPEALKKI 490 + E ++ IK+G+ + D P + +L K+ Sbjct: 232 ICEQQLI----MCIKSGNRPDVDDITEYCPREIISLMKL 266
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 57.0 bits (136), Expect = 3e-08 Identities = 35/95 (36%), Positives = 54/95 (56%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 ++ +EYL G +HRD+ + N+L+ ED+ A+V+DFGL+ S +LP Sbjct: 295 SLDVCEAMEYLEGNN---FVHRDLAARNVLVSEDNVAKVSDFGLT--KEASSTQDTGKLP 349 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + + PE R +TKSDV+SFG++L EI S Sbjct: 350 ---VKWTAPEALREKKFSTKSDVWSFGILLWEIYS 381
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 57.0 bits (136), Expect = 3e-08 Identities = 35/95 (36%), Positives = 54/95 (56%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 ++ +EYL G +HRD+ + N+L+ ED+ A+V+DFGL+ S +LP Sbjct: 295 SLDVCEAMEYLEGNN---FVHRDLAARNVLVSEDNVAKVSDFGLT--KEASSTQDTGKLP 349 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + + PE R +TKSDV+SFG++L EI S Sbjct: 350 ---VKWTAPEALREKKFSTKSDVWSFGILLWEIYS 381
>SPEG_HUMAN (Q15772) Striated muscle preferentially expressed protein kinase (EC| 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Length = 3223 Score = 57.0 bits (136), Expect = 3e-08 Identities = 38/115 (33%), Positives = 60/115 (52%), Gaps = 3/115 (2%) Frame = +2 Query: 59 TIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSE 238 T VQ +G++YLHG+ V+H DIK N+L+ D+ ++ DFG + + PL Sbjct: 3064 TYMVQLLQGLDYLHGHH---VLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGH 3120 Query: 239 LPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAI---DMQLEEGNIV 394 GTL ++ PE + + + +D++ GV+ +LSGR D Q E IV Sbjct: 3121 -RTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIV 3174 Score = 35.4 bits (80), Expect = 0.096 Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDE----DHNARVADFGLSIMGPVDSGTPLSE 238 Q GI YLH V+H D+K N+L+ + + R+ DFG + + G P Sbjct: 1702 QVLEGIHYLHQ---SHVLHLDVKPENLLVWDGAAGEQQVRICDFGNA--QELTPGEP-QY 1755 Query: 239 LPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 GT ++ PE ++ +D++ GVV L+G Sbjct: 1756 CQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTG 1793
>RIPK5_MOUSE (Q6XUX1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/111 (32%), Positives = 57/111 (51%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L R+ IA+ GI +LH ++HRDIK N+L+D+ + A++ D G Sbjct: 741 TGLKAGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFC 797 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ I SG Sbjct: 798 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYICSG 842
>PGFRB_CANFA (Q6QNF3) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1103 Score = 57.0 bits (136), Expect = 3e-08 Identities = 39/115 (33%), Positives = 57/115 (49%) Frame = +2 Query: 5 CMARXSNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVA 184 C A N L++T V + Q A G+E+L C +HRD+ + N+LI E ++ Sbjct: 787 CRATLINESPVLSYTDLVGFSYQVANGMEFLASKNC---VHRDLAARNVLICEGKLVKIC 843 Query: 185 DFGLSIMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 DFGL+ DS L ++ PE TT SDV+SFG++L EI + Sbjct: 844 DFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT 898
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 56.6 bits (135), Expect = 4e-08 Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 5/106 (4%) Frame = +2 Query: 44 WTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSG 223 W +RV+ A A G+ YLH +IHRD+ S N L+ ED VA+FGLS + P ++ Sbjct: 409 WNQRVSFARDIAAGMTYLHSMN---IIHRDLNSHNCLVREDGGLVVANFGLSRLIPEETR 465 Query: 224 TPLSE-----LPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEIL 346 + G ++ PE DV+SFG+V+ EI+ Sbjct: 466 DLRKDRRKRYTVVGNPYWMAPEMINGRSYDESVDVFSFGIVICEII 511
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/97 (39%), Positives = 50/97 (51%), Gaps = 2/97 (2%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A + Y H VIHRDIK N+L+ + ++ADFG S+ P T L G Sbjct: 246 QLAEALLYCHS---KKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTL----CG 298 Query: 251 TLGYLDPEYY--RLHYLTTKSDVYSFGVVLLEILSGR 355 TL YL PE R+H T D++S GV+ E L G+ Sbjct: 299 TLDYLPPEMIEGRMHDETV--DLWSLGVLCYEFLVGK 333
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 56.6 bits (135), Expect = 4e-08 Identities = 32/102 (31%), Positives = 56/102 (54%) Frame = +2 Query: 47 TRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGT 226 TR T + +A +EYLHG +IHRD+K NIL++ED + ++ DFG + + +S Sbjct: 185 TRFYTAEIVSA--LEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQ 239 Query: 227 PLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + GT Y+ PE SD+++ G ++ ++++G Sbjct: 240 ARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAG 281
>RON_HUMAN (Q04912) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Length = 1400 Score = 56.6 bits (135), Expect = 4e-08 Identities = 35/100 (35%), Positives = 56/100 (56%), Gaps = 2/100 (2%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS--IMGPVDSGTP 229 ++ +Q ARG+EYL A +HRD+ + N ++DE +VADFGL+ I+ Sbjct: 1186 ISFGLQVARGMEYL---AEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQ 1242 Query: 230 LSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + ++ E + + TTKSDV+SFGV+L E+L+ Sbjct: 1243 QHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLT 1282
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 56.6 bits (135), Expect = 4e-08 Identities = 35/105 (33%), Positives = 57/105 (54%), Gaps = 2/105 (1%) Frame = +2 Query: 47 TRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGT 226 ++ TI + ++ H +IHRD+K +NI+I+ +V DFG++ DS + Sbjct: 111 SQAATIMIPVCHALQSSHEAG---IIHRDVKPANIMINNTGGVKVMDFGIA-RALDDSTS 166 Query: 227 PLSELPA--GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 +++ A GT YL PE R +SDVY+ G VL E+++GR Sbjct: 167 AMTQTAAVIGTAQYLSPEQARGKPADARSDVYAAGCVLYELVTGR 211
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 56.6 bits (135), Expect = 4e-08 Identities = 36/108 (33%), Positives = 61/108 (56%), Gaps = 2/108 (1%) Frame = +2 Query: 32 KQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGP 211 + L++ + IA Q A G+EYL +IHRD+ + N+LI E++ A++ DFGL+ + Sbjct: 374 RYLHFEDLIYIATQVASGMEYLES---KQLIHRDLAARNVLIGENNVAKICDFGLARVIA 430 Query: 212 VDSGTPL--SELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 D P S P + + PE + KSDV+S+G++L+E+ + Sbjct: 431 DDEYCPKQGSRFP---VKWTAPEAIIYGKFSIKSDVWSYGILLMELFT 475
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 56.6 bits (135), Expect = 4e-08 Identities = 35/95 (36%), Positives = 54/95 (56%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 ++ +EYL G +HRD+ + N+L+ ED+ A+V+DFGL+ S +LP Sbjct: 295 SLDVLEAMEYLEGNN---FVHRDLAARNVLVSEDNVAKVSDFGLT--KEASSTQDTGKLP 349 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 + + PE R +TKSDV+SFG++L EI S Sbjct: 350 ---VKWTAPEALREKKFSTKSDVWSFGILLWEIYS 381
>CHK1_USTMA (P0C198) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 662 Score = 56.6 bits (135), Expect = 4e-08 Identities = 35/94 (37%), Positives = 47/94 (50%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q G+EY+H V HRDIK N+L+D + N ++ADFGL + G Sbjct: 176 QLLAGLEYIHSQG---VTHRDIKPENMLLDAEGNLKIADFGLCSVYKYKGKERELTGACG 232 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 +L Y+ PE Y DV+S GVVL +L G Sbjct: 233 SLPYIAPEMNGKPYRGEPVDVWSSGVVLFAMLVG 266
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 56.6 bits (135), Expect = 4e-08 Identities = 43/124 (34%), Positives = 65/124 (52%), Gaps = 9/124 (7%) Frame = +2 Query: 23 NLKKQLN----WTRRVTIAVQAARGIEYLHGYACPP---VIHRDIKSSNILIDEDHNARV 181 NL+ ++N ++ R T+ V A E L G A V+HRDIK NILI++ + ++ Sbjct: 101 NLRHEMNAQGTFSVRETLRVVA----ETLDGLASAHRAGVVHRDIKPENILINDRGHVQI 156 Query: 182 ADFGLSIMGPVDSGTPLSE--LPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 DFGL+ S LS + GT YL PE + T + D+YS G++ E+L+G+ Sbjct: 157 TDFGLA---KAASQATLSSTGMLLGTAAYLAPEMIENNQATAQGDLYSVGIMAWEMLTGK 213 Query: 356 KAID 367 D Sbjct: 214 VPFD 217
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 56.6 bits (135), Expect = 4e-08 Identities = 34/94 (36%), Positives = 51/94 (54%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELPAG 250 Q A + Y+H +IHRD+K N+LI D+ ++ADFG SI+ P G+ L G Sbjct: 206 QIADALHYMHKKR---IIHRDVKPENVLIGFDNVVKLADFGWSILNP--EGSKRKTL-CG 259 Query: 251 TLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T+ YL PE + DV++ GV+ E++ G Sbjct: 260 TIDYLSPEMITPREYDEQVDVWALGVLAYELVVG 293
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 56.6 bits (135), Expect = 4e-08 Identities = 32/102 (31%), Positives = 56/102 (54%) Frame = +2 Query: 47 TRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGT 226 TR T + +A +EYLHG +IHRD+K NIL++ED + ++ DFG + + +S Sbjct: 182 TRFYTAEIVSA--LEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQ 236 Query: 227 PLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + GT Y+ PE SD+++ G ++ ++++G Sbjct: 237 ARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAG 278
>GPRK2_DROME (P32866) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 714 Score = 56.6 bits (135), Expect = 4e-08 Identities = 32/106 (30%), Positives = 56/106 (52%) Frame = +2 Query: 65 AVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSELP 244 A + A G+++LH +++RD K NIL+D+ + R++D GL++ P + Sbjct: 416 AAEVACGLQHLHKQG---IVYRDCKPENILLDDHGHVRISDLGLAVEIPEGE---MVRGR 469 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 GT+GY+ PE D +SFG +L E++ G+ M+ E+ Sbjct: 470 VGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEK 515
>RIPK5_BRARE (Q4VSN1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 885 Score = 56.6 bits (135), Expect = 4e-08 Identities = 35/111 (31%), Positives = 58/111 (52%) Frame = +2 Query: 20 SNLKKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS 199 + LK L+ R+ IA+ GI +LH ++HRDIK N+L+D+ + A++ D G Sbjct: 705 TGLKAGLSLKERLLIALDVVEGIRFLHSQG---LLHRDIKLKNVLLDKQNRAKITDLGFC 761 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 + SG+ + GT ++ PE + Y DVY+FG++ + SG Sbjct: 762 KPEAMMSGSIV-----GTPIHMAPELFTGKY-DNSVDVYAFGILFWYLCSG 806
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 56.6 bits (135), Expect = 4e-08 Identities = 34/105 (32%), Positives = 59/105 (56%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPV 214 +L+ R + ++ Q A G+ Y+ IHRD++++NIL+ E ++ADFGL+ + + Sbjct: 324 RLSLPRLIDMSAQVAEGMAYIERMNS---IHRDLRAANILVSETLCCKIADFGLARI--I 378 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 DS E + + PE T K+DV+SFGV+L+ I++ Sbjct: 379 DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMVIVT 423
>VGFR1_HUMAN (P17948) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) Length = 1338 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 3/110 (2%) Frame = +2 Query: 29 KKQLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS--- 199 K+ + ++ + Q ARG+E+L C IHRD+ + NIL+ E++ ++ DFGL+ Sbjct: 991 KEPITMEDLISYSFQVARGMEFLSSRKC---IHRDLAARNILLSENNVVKICDFGLARDI 1047 Query: 200 IMGPVDSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILS 349 P + LP L ++ PE +TKSDV+S+GV+L EI S Sbjct: 1048 YKNPDYVRKGDTRLP---LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094
>PHY1_CERPU (P25848) Light-sensor Protein kinase [Includes: Phytochrome; Protein| kinase (EC 2.7.11.1)] Length = 1307 Score = 56.6 bits (135), Expect = 4e-08 Identities = 46/125 (36%), Positives = 60/125 (48%), Gaps = 26/125 (20%) Frame = +2 Query: 56 VTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDH---------NARVADFGLSIMG 208 V I +Q + G+ YLH +IHRD+KS NIL+ + +VADFGLS Sbjct: 1105 VDIILQTSEGMNYLHEKG---IIHRDLKSMNILVKSVKVTKSEIGYVHVKVADFGLS--K 1159 Query: 209 PVDSGTPLSELP--AGTLGYLDPEYYRLHYLTT---------------KSDVYSFGVVLL 337 DS T S GT ++ PE L Y +T KSDVYSFG+V Sbjct: 1160 TKDSSTRYSNQTWNRGTNRWMAPEVINLGYESTEGEISFDGKVPKYPLKSDVYSFGMVCY 1219 Query: 338 EILSG 352 E+L+G Sbjct: 1220 EVLTG 1224
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 56.6 bits (135), Expect = 4e-08 Identities = 32/106 (30%), Positives = 55/106 (51%) Frame = +2 Query: 35 QLNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPV 214 ++N + T+ + R + YLH VIHRDIKS +IL+ D +++DFG V Sbjct: 539 RMNEEQIATVCLSVLRALSYLHNQG---VIHRDIKSDSILLTSDGRIKLSDFG--FCAQV 593 Query: 215 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 P + GT ++ PE T+ D++S G++++E++ G Sbjct: 594 SKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDG 639
>KPCT_HUMAN (Q04759) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 706 Score = 56.2 bits (134), Expect = 5e-08 Identities = 36/115 (31%), Positives = 60/115 (52%), Gaps = 3/115 (2%) Frame = +2 Query: 47 TRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGL---SIMGPVD 217 +R A + G+++LH +++RD+K NIL+D+D + ++ADFG+ +++G Sbjct: 479 SRATFYAAEIILGLQFLHSKG---IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAK 535 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEE 382 + T GT Y+ PE D +SFGV+L E+L G+ Q EE Sbjct: 536 TNT-----FCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEE 585
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 56.2 bits (134), Expect = 5e-08 Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 2/98 (2%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLSE--LP 244 Q R ++ H ++HRD+K NILI ++ DFG++ VD+ P+++ + Sbjct: 124 QTGRALQIAHAAG---LVHRDVKPGNILITPTGQVKITDFGIA--KAVDAA-PVTQTGMV 177 Query: 245 AGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRK 358 GT Y+ PE H T SDVYS GV+ E++SG++ Sbjct: 178 MGTAQYIAPEQALGHDATPASDVYSLGVIGYEVVSGKR 215
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/113 (32%), Positives = 56/113 (49%), Gaps = 14/113 (12%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGP------------- 211 Q A GI YLH ++HRD+K N+L+D+ N +++DFG + M P Sbjct: 131 QMALGIAYLHSKG---IVHRDLKLENLLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQ 187 Query: 212 VDSGTPLSELPAGTLGYLDPE-YYRLHYLTTKSDVYSFGVVLLEILSGRKAID 367 ++S + LS+ G+ Y PE L Y SD +S GV+L ++ R D Sbjct: 188 MNSLSHLSQTYCGSFAYACPEILLGLPYNPFLSDTWSMGVILYTLVVARLPFD 240
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 3/105 (2%) Frame = +2 Query: 47 TRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNIL---IDEDHNARVADFGLSIMGPVD 217 T T+ Q A G+E +H ++HRD+K N L + +D ++ DFGLS V+ Sbjct: 146 TEAATVVHQIASGLEAVHR---ANIVHRDLKPENCLFLDVRKDSPLKIMDFGLS---SVE 199 Query: 218 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSG 352 T G++ Y+ PE +TTKSD++S GV+L +LSG Sbjct: 200 EFTDPVVGLFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSG 244
>WNK3_HUMAN (Q9BYP7) Serine/threonine-protein kinase WNK3 (EC 2.7.11.1)| (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) Length = 1743 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 1/127 (0%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILI-DEDHNARVADFGLSIMGPVDSGTPLSELPA 247 Q +G+++LH PP+IHRD+K NI I + ++ D GL+ + T ++ Sbjct: 256 QILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTGSVKIGDLGLATL----MRTSFAKSVI 310 Query: 248 GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQLEEGNIVEWAAPLIKAGD 427 GT ++ PE Y HY DVY+FG+ +LE+ + I IK Sbjct: 311 GTPEFMAPEMYEEHY-DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPAS 369 Query: 428 ISGILDP 448 + + DP Sbjct: 370 FNKVTDP 376
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 56.2 bits (134), Expect = 5e-08 Identities = 48/145 (33%), Positives = 66/145 (45%), Gaps = 35/145 (24%) Frame = +2 Query: 38 LNWTRRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGL--SIMGP 211 L W +RV +A A G+ YLH +IHRD+ S N L+ ED + VADFGL S+ P Sbjct: 494 LPWPQRVRLARDIACGMSYLHSMN---IIHRDLNSMNCLVREDRSVIVADFGLARSVDAP 550 Query: 212 ---------------VDSGTPLSELPAGTLG------------------YLDPEYYRLHY 292 +S P+S P+GTL ++ PE + Sbjct: 551 RLPSGNMTPGGYGSGANSDAPMS--PSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLK 608 Query: 293 LTTKSDVYSFGVVLLEILSGRKAID 367 K DV+SFG++L EI+ GR D Sbjct: 609 YDEKVDVFSFGIMLCEII-GRVEAD 632
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 56.2 bits (134), Expect = 5e-08 Identities = 31/99 (31%), Positives = 59/99 (59%), Gaps = 4/99 (4%) Frame = +2 Query: 71 QAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSIMGPVDSGTPLS--ELP 244 Q +G+EYLH ++HRDIK +NIL+D +++DFG+S ++S + + P Sbjct: 505 QTLKGLEYLHSRG---IVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARP 561 Query: 245 A--GTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGR 355 + G+ ++ PE + T K+D++S G +++E+L+ + Sbjct: 562 SFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSK 600 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 80,119,327 Number of Sequences: 219361 Number of extensions: 1738144 Number of successful extensions: 7871 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6643 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6954 length of database: 80,573,946 effective HSP length: 104 effective length of database: 57,760,402 effective search space used: 3985467738 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
