ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags6j14 |
|---|---|
| Clone Library Name | barley_pub |
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 110 bits (276), Expect(2) = 4e-35 Identities = 54/98 (55%), Positives = 71/98 (72%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+W +R+ I + AARG+ YLH A +IHRD+K++NIL+DE A+V+DFGLS GP+ Sbjct: 603 LNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPAD 662 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 T +S + G+ GYLDPEY+R LT KSDVYSFGVV Sbjct: 663 SGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVV 700 Score = 55.8 bits (133), Expect(2) = 4e-35 Identities = 21/38 (55%), Positives = 33/38 (86%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 S+L H HL++L+GYCE+ +E +LVY++MAHG+L +HL+ Sbjct: 556 SRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLH 593
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 120 bits (302), Expect(2) = 6e-35 Identities = 58/98 (59%), Positives = 73/98 (74%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L W RL I +GAARGL YLHT ++IHRDVK++NILLD+ AKV+DFG SK P Sbjct: 691 LDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQE 750 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++VS V+G+ GYLDPEY++ Q L+EKSDV+SFGVV Sbjct: 751 GDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVV 788 Score = 45.4 bits (106), Expect(2) = 6e-35 Identities = 18/38 (47%), Positives = 29/38 (76%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 S ++H +LV L+GYC E ++ ILVY +M++G+L + LY Sbjct: 645 SAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLY 682
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 120 bits (300), Expect(2) = 1e-34 Identities = 58/98 (59%), Positives = 72/98 (73%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L W RL I +GAARGL YLHT ++IHRDVK++NILLD AKV+DFG SK P Sbjct: 690 LDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQE 749 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++VS V+G+ GYLDPEY++ Q L+EKSDV+SFGVV Sbjct: 750 GDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVV 787 Score = 45.4 bits (106), Expect(2) = 1e-34 Identities = 18/38 (47%), Positives = 29/38 (76%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 S ++H +LV L+GYC E ++ ILVY +M++G+L + LY Sbjct: 644 SAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLY 681
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 119 bits (297), Expect(2) = 3e-34 Identities = 58/98 (59%), Positives = 72/98 (73%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LSW +RL+I + AA+GL YLH G K I+HRDVK TNILL+EK AK++DFGLS++ Sbjct: 666 LSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVE 725 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +STVV GS GYLDPEY+ + + EKSDVYS GVV Sbjct: 726 GSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVV 763 Score = 45.1 bits (105), Expect(2) = 3e-34 Identities = 17/36 (47%), Positives = 27/36 (75%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++ H +L SL+GYC E N M+L+Y+YMA+ L ++L Sbjct: 623 RVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYL 658
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 115 bits (287), Expect(2) = 5e-34 Identities = 57/99 (57%), Positives = 75/99 (75%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLSW+ RL++ +GAA+GL +LH+ ++ +I+RD KT+NILLD ++ AK+SDFGL+K GP Sbjct: 172 PLSWKLRLKVALGAAKGLAFLHS-SETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPI 230 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D +HVST V G+ GY PEY LT KSDVYSFGVV Sbjct: 231 GDKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFGVV 269 Score = 48.1 bits (113), Expect(2) = 5e-34 Identities = 19/35 (54%), Positives = 25/35 (71%) Frame = +3 Query: 21 HRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 HRHLV LIGYC E +LVY++M G+L HL++ Sbjct: 131 HRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFR 165
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 116 bits (291), Expect(2) = 7e-33 Identities = 56/99 (56%), Positives = 76/99 (76%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLSW RL++ +GAA+GL +LH A+ ++I+RD KT+NILLD ++ AK+SDFGL+K GP+ Sbjct: 173 PLSWTLRLKVALGAAKGLAFLHN-AETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPT 231 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D +HVST + G++GY PEY LT KSDVYS+GVV Sbjct: 232 GDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVV 270 Score = 42.7 bits (99), Expect(2) = 7e-33 Identities = 17/35 (48%), Positives = 24/35 (68%) Frame = +3 Query: 21 HRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 H +LV LIGYC E +LVY++M G+L HL++ Sbjct: 132 HPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFR 166
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 114 bits (286), Expect(2) = 1e-32 Identities = 56/99 (56%), Positives = 69/99 (69%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PL W R++I GAARGL YLH +I+RD+K +NILL E + K+SDFGL+K GPS Sbjct: 198 PLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPS 257 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D THVST V G++GY P+Y LT KSD+YSFGVV Sbjct: 258 GDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVV 296 Score = 43.9 bits (102), Expect(2) = 1e-32 Identities = 17/34 (50%), Positives = 26/34 (76%) Frame = +3 Query: 21 HRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 H +LV LIG+C E ++ +LVY+YM G+L +HL+ Sbjct: 157 HPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLH 190
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 114 bits (284), Expect(2) = 1e-32 Identities = 56/103 (54%), Positives = 71/103 (68%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P L W R++I GAA+GL +LH A +I+RD K++NILLDE + K+SDFGL+K Sbjct: 177 PDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAK 236 Query: 307 TGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 GP+ D +HVST V G++GY PEY LT KSDVYSFGVV Sbjct: 237 LGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVV 279 Score = 44.3 bits (103), Expect(2) = 1e-32 Identities = 18/38 (47%), Positives = 29/38 (76%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 S L H +LV+LIGYC + ++ +LVY++M G+L +HL+ Sbjct: 136 SLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLH 173
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 109 bits (272), Expect(2) = 2e-31 Identities = 55/99 (55%), Positives = 71/99 (71%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLSW R+ + +GAARGL +LH A+ +I+RD K +NILLD + AK+SDFGL++ GP Sbjct: 172 PLSWNTRVRMALGAARGLAFLHN-AQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPM 230 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D++HVST V G+ GY PEY L+ KSDVYSFGVV Sbjct: 231 GDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVV 269 Score = 45.1 bits (105), Expect(2) = 2e-31 Identities = 18/38 (47%), Positives = 27/38 (71%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 +L H +LV LIGYC E+ +LVY++M G+L HL++ Sbjct: 128 QLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFR 165
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 104 bits (259), Expect(2) = 3e-31 Identities = 51/101 (50%), Positives = 71/101 (70%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 N P W R++I IGAARGL +LH+ + +I+RD K +NILLD + AK+SDFGL+K G Sbjct: 185 NDPFPWDLRIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFGLAKLG 243 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 P+ + +HV+T + G++GY PEY L KSDV++FGVV Sbjct: 244 PADEKSHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVV 284 Score = 49.7 bits (117), Expect(2) = 3e-31 Identities = 19/37 (51%), Positives = 28/37 (75%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 L HR+LV L+GYC E E++LVY++M G+L HL++ Sbjct: 147 LSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFR 183
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 94.4 bits (233), Expect(2) = 1e-30 Identities = 48/99 (48%), Positives = 63/99 (63%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PL W+QRL + + ARG+ YLH A + IHRD+K +NILL + AKV+DFGL + P Sbjct: 685 PLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPE 744 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + T + G+FGYL PEY +T K DVYSFGV+ Sbjct: 745 -GKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVYSFGVI 782 Score = 57.4 bits (137), Expect(2) = 1e-30 Identities = 23/39 (58%), Positives = 32/39 (82%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 +K+RHRHLV+L+GYC + NE +LVY+YM GTL HL++ Sbjct: 639 TKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFE 677
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 105 bits (261), Expect(2) = 1e-29 Identities = 53/98 (54%), Positives = 69/98 (70%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L W +RL+I +GAARGL +LH G IIHRD+K +NILLD + KV+DFGL++ S Sbjct: 1012 LDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARL-ISA 1070 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +HVSTV+ G+FGY+ PEY + T K DVYSFGV+ Sbjct: 1071 CESHVSTVIAGTFGYIPPEYGQSARATTKGDVYSFGVI 1108 Score = 43.5 bits (101), Expect(2) = 1e-29 Identities = 19/40 (47%), Positives = 29/40 (72%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 K++H +LVSL+GYC E +LVY+YM +G+L +H + Q Sbjct: 967 KVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSL-DHWLRNQ 1005
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 97.4 bits (241), Expect(2) = 9e-28 Identities = 51/114 (44%), Positives = 75/114 (65%), Gaps = 1/114 (0%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 +E + T+ L W R +I IGAARGL +LH IIHRD+K++N+LLD+ +V Sbjct: 939 LETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFV 998 Query: 277 AKVSDFGLSKTGPSMD-HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 A+VSDFG+++ ++D H VST+ G+ GY+ PEY++ T K DVYS+GV+ Sbjct: 999 ARVSDFGMARLVSALDTHLSVSTLA-GTPGYVPPEYYQSFRCTAKGDVYSYGVI 1051 Score = 44.7 bits (104), Expect(2) = 9e-28 Identities = 18/38 (47%), Positives = 29/38 (76%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 K++HR+LV L+GYC+ E +LVY+YM +G+L L++ Sbjct: 908 KIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHE 945
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 94.7 bits (234), Expect(2) = 3e-27 Identities = 50/99 (50%), Positives = 69/99 (69%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+W R +I IGAARGL +LH IIHRD+K++N+LLDE A+VSDFG+++ +M Sbjct: 983 LNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAM 1042 Query: 322 D-HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D H VST+ G+ GY+ PEY++ + K DVYS+GVV Sbjct: 1043 DTHLSVSTLA-GTPGYVPPEYYQSFRCSTKGDVYSYGVV 1080 Score = 45.8 bits (107), Expect(2) = 3e-27 Identities = 18/37 (48%), Positives = 29/37 (78%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 K++HR+LV L+GYC+ E +LVY+YM +G+L + L+ Sbjct: 938 KIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLH 974
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 94.7 bits (234), Expect(2) = 3e-27 Identities = 50/99 (50%), Positives = 69/99 (69%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+W R +I IGAARGL +LH IIHRD+K++N+LLDE A+VSDFG+++ +M Sbjct: 983 LNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAM 1042 Query: 322 D-HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D H VST+ G+ GY+ PEY++ + K DVYS+GVV Sbjct: 1043 DTHLSVSTLA-GTPGYVPPEYYQSFRCSTKGDVYSYGVV 1080 Score = 45.8 bits (107), Expect(2) = 3e-27 Identities = 18/37 (48%), Positives = 29/37 (78%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 K++HR+LV L+GYC+ E +LVY+YM +G+L + L+ Sbjct: 938 KIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLH 974
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 95.1 bits (235), Expect(2) = 5e-27 Identities = 49/99 (49%), Positives = 69/99 (69%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+W R +I IG+ARGL +LH IIHRD+K++N+LLDE A+VSDFG+++ +M Sbjct: 978 LNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAM 1037 Query: 322 D-HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D H VST+ G+ GY+ PEY++ + K DVYS+GVV Sbjct: 1038 DTHLSVSTLA-GTPGYVPPEYYQSFRCSTKGDVYSYGVV 1075 Score = 44.7 bits (104), Expect(2) = 5e-27 Identities = 17/37 (45%), Positives = 30/37 (81%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 K++HR+LV L+GYC+ +E +LVY++M +G+L + L+ Sbjct: 933 KIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLH 969
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 95.9 bits (237), Expect(2) = 6e-27 Identities = 49/99 (49%), Positives = 70/99 (70%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+W R +I IGAARGL +LH IIHRD+K++N+LLDE + A+VSDFG+++ ++ Sbjct: 956 LNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSAL 1015 Query: 322 D-HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D H VST+ G+ GY+ PEY++ T K DVYS+GV+ Sbjct: 1016 DTHLSVSTLA-GTPGYVPPEYYQSFRCTAKGDVYSYGVI 1053 Score = 43.5 bits (101), Expect(2) = 6e-27 Identities = 18/38 (47%), Positives = 28/38 (73%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 K++HR+LV L+GYC+ E +LVY+YM G+L L++ Sbjct: 909 KIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHE 946
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 97.1 bits (240), Expect(2) = 8e-27 Identities = 49/98 (50%), Positives = 66/98 (67%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L W+ RL I GAA GL YLH + I+HRD+K++NILL + +VA ++DFGL++ Sbjct: 838 LDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPY 897 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D THV+T + G+ GY+ PEY + T K DVYSFGVV Sbjct: 898 D-THVTTDLVGTLGYIPPEYGQASVATYKGDVYSFGVV 934 Score = 42.0 bits (97), Expect(2) = 8e-27 Identities = 17/39 (43%), Positives = 28/39 (71%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S+ +H +LV L+GYC KN+ +L+Y YM +G+L L++ Sbjct: 792 SRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHE 830
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 100 bits (249), Expect(2) = 2e-26 Identities = 52/100 (52%), Positives = 68/100 (68%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L W+ RL I GAA+GL YLH G I+HRD+K++NILLDE + + ++DFGL++ Sbjct: 827 ALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARL-M 885 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S THVST + G+ GY+ PEY + T K DVYSFGVV Sbjct: 886 SPYETHVSTDLVGTLGYIPPEYGQASVATYKGDVYSFGVV 925 Score = 37.4 bits (85), Expect(2) = 2e-26 Identities = 16/39 (41%), Positives = 27/39 (69%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S+ +H +LV L G+C KN+ +L+Y YM +G+L L++ Sbjct: 783 SRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHE 821
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 89.7 bits (221), Expect(2) = 1e-25 Identities = 47/99 (47%), Positives = 67/99 (67%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L W +R +I GAA+GL +LH IIHRD+K++N+LLD+ A+VSDFG+++ ++ Sbjct: 935 LGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISAL 994 Query: 322 D-HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D H VST+ G+ GY+ PEY++ T K DVYS GVV Sbjct: 995 DTHLSVSTLA-GTPGYVPPEYYQSFRCTAKGDVYSIGVV 1032 Score = 45.1 bits (105), Expect(2) = 1e-25 Identities = 18/37 (48%), Positives = 29/37 (78%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 K++HR+LV L+GYC+ E +LVY++M +G+L E L+ Sbjct: 888 KIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLH 924
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 99.8 bits (247), Expect(2) = 2e-25 Identities = 50/99 (50%), Positives = 66/99 (66%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PL W +R I +G+ARGL YLH IIHRDVK NILLDE++ A V DFGL+K Sbjct: 384 PLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDY 443 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D THV+T V+G+ G++ PEY +EK+DV+ +GV+ Sbjct: 444 KD-THVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVM 481 Score = 34.7 bits (78), Expect(2) = 2e-25 Identities = 14/29 (48%), Positives = 21/29 (72%) Frame = +3 Query: 21 HRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 HR+L+ L G+C E +LVY YMA+G++ Sbjct: 343 HRNLLRLRGFCMTPTERLLVYPYMANGSV 371
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 89.7 bits (221), Expect(2) = 5e-25 Identities = 46/98 (46%), Positives = 60/98 (61%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L W R + + AA+GL YLH I+HRDVK+ NILLD + A V+DFGL+K Sbjct: 786 LQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLVDG 845 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + + + GS+GY+ PEY + EKSDVYSFGVV Sbjct: 846 AASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVV 883 Score = 43.1 bits (100), Expect(2) = 5e-25 Identities = 17/37 (45%), Positives = 28/37 (75%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 ++RHRH+V L+GY K+ +L+Y+YM +G+L E L+ Sbjct: 743 RIRHRHIVRLLGYVANKDTNLLLYEYMPNGSLGELLH 779
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 97.1 bits (240), Expect(2) = 2e-24 Identities = 47/107 (43%), Positives = 71/107 (66%), Gaps = 1/107 (0%) Frame = +1 Query: 118 YTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFG 297 + + + L+W +R +I G ARGL YLH ++ IIHRD+K +NILLD+ + K+SDFG Sbjct: 614 FGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFG 673 Query: 298 LSKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +++ D T +T+ V G++GY+ PEY +EKSDV+SFGV+ Sbjct: 674 MARIF-ERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVI 719 Score = 34.3 bits (77), Expect(2) = 2e-24 Identities = 13/38 (34%), Positives = 28/38 (73%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 ++L+H +LV ++G C E +E +L+Y+Y+ + +L +L+ Sbjct: 577 ARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLF 614
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 91.7 bits (226), Expect(2) = 3e-23 Identities = 46/99 (46%), Positives = 67/99 (67%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLSW R +I GAA G+++LH ++ IHRD+K+ NILLDE + AK+SDFGL++ Sbjct: 282 PLSWHMRCKIAQGAANGINFLH---ENHHIHRDIKSANILLDEAFTAKISDFGLARASEK 338 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 T +++ + G+ Y+ PE R + +T KSD+YSFGVV Sbjct: 339 FAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVV 376 Score = 35.4 bits (80), Expect(2) = 3e-23 Identities = 14/37 (37%), Positives = 26/37 (70%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +K +H +LV L+G+ + +++ LVY YM +G+L + L Sbjct: 238 AKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRL 274
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 94.0 bits (232), Expect(2) = 2e-22 Identities = 49/106 (46%), Positives = 63/106 (59%), Gaps = 2/106 (1%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L W +RL I + AA GL YLH I+HRDVK++NILLD + AKV+DFG++ Sbjct: 782 RKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIA 841 Query: 304 KTG--PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K G + + GS GY+ PEY + EKSD+YSFGVV Sbjct: 842 KVGQMSGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVV 887 Score = 30.0 bits (66), Expect(2) = 2e-22 Identities = 13/36 (36%), Positives = 23/36 (63%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 +RH+ +V L C + +LVY+YM +G+L + L+ Sbjct: 744 IRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLH 779
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 87.8 bits (216), Expect(2) = 1e-21 Identities = 43/99 (43%), Positives = 66/99 (66%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLSW R ++ G A G+ +LH ++ IHRD+K+ NILLD+ + AK+SDFGL++ Sbjct: 282 PLSWHTRCKVAQGTANGIRFLH---ENHHIHRDIKSANILLDKDFTAKISDFGLARASAR 338 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + T +++ + G+ Y+ PE R + +T KSD+YSFGVV Sbjct: 339 LAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVV 376 Score = 33.9 bits (76), Expect(2) = 1e-21 Identities = 13/34 (38%), Positives = 23/34 (67%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H +LV L+G+ + + + LVY YM +G+L + L Sbjct: 241 QHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRL 274
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 81.3 bits (199), Expect(2) = 2e-21 Identities = 44/108 (40%), Positives = 65/108 (60%), Gaps = 8/108 (7%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL----- 300 +PLSW QRL+I +G AR + +LH + ++IH D+K++N+LLDE+ + K+ DFGL Sbjct: 308 SPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLMPKLGDFGLARFSR 366 Query: 301 ---SKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +K S ST V+G+ YL EY + L +D +SFGVV Sbjct: 367 FAGAKASQSSTVARTST-VRGTLAYLPEEYIKTGRLAVDTDTFSFGVV 413 Score = 39.7 bits (91), Expect(2) = 2e-21 Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 1/45 (2%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY-KTQXCT 140 S+ RH ++V GYC E LVY ++ +G+L + L+ +TQ C+ Sbjct: 264 SRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACS 308
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 81.6 bits (200), Expect(2) = 4e-21 Identities = 43/106 (40%), Positives = 64/106 (60%), Gaps = 7/106 (6%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK---- 306 PLSW QRL+I +G AR + +LH + ++IH D+K++N+LLDE+ K+ DFGL++ Sbjct: 309 PLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF 367 Query: 307 --TGPSMDHTHVST-VVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + PS T V+G+ YL EY + L +D +SFGVV Sbjct: 368 AGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVV 413 Score = 38.1 bits (87), Expect(2) = 4e-21 Identities = 16/44 (36%), Positives = 27/44 (61%), Gaps = 1/44 (2%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY-KTQXC 137 S+ RH ++V GYC + LVY ++ +G+L + L+ +TQ C Sbjct: 264 SRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQAC 307
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 82.0 bits (201), Expect(2) = 9e-20 Identities = 42/99 (42%), Positives = 55/99 (55%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PL W R I +G A GL YLH I+HRD+K NILLD +SDFG++K Sbjct: 910 PLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQ 969 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + S V+G+ GY+ PE + +SDVYS+GVV Sbjct: 970 SATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYGVV 1008 Score = 33.1 bits (74), Expect(2) = 9e-20 Identities = 14/39 (35%), Positives = 26/39 (66%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKT 128 K+RHR+L+ L + K +++Y YM +G+L + L++T Sbjct: 867 KVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHET 905
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 84.3 bits (207), Expect(2) = 1e-18 Identities = 44/99 (44%), Positives = 61/99 (61%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP-S 318 L+W+QR I +G ARG+++LHT +IH D+K NILLD+ K+ DFGL + GP S Sbjct: 315 LTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKS 374 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +D V G+ YL PE+ + L+ DVYSFG+V Sbjct: 375 LDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIV 413 Score = 26.9 bits (58), Expect(2) = 1e-18 Identities = 12/37 (32%), Positives = 21/37 (56%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + +RH ++++L GY + + LVY M G+L L Sbjct: 267 NSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARL 303
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 69.7 bits (169), Expect(2) = 2e-17 Identities = 36/103 (34%), Positives = 57/103 (55%), Gaps = 4/103 (3%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLSW R+ + IG A+ + YLH +I +V + NILLD++ K++DF + P+ Sbjct: 274 PLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPN 333 Query: 319 MDHTHVSTVVKGS----FGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ + + G Y+ EY R L+ K+DVYSFG+V Sbjct: 334 LEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIV 376 Score = 37.4 bits (85), Expect(2) = 2e-17 Identities = 17/41 (41%), Positives = 24/41 (58%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXCT 140 RH H++ L Y E ++ LVY YM++GTL + L T T Sbjct: 233 RHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTT 273
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 77.4 bits (189), Expect(2) = 3e-17 Identities = 38/105 (36%), Positives = 65/105 (61%) Frame = +1 Query: 121 TRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 ++P L+W +R +I +G ARGL YLHTG + IIH ++++ N+L+D+ + A++++FGL Sbjct: 462 SKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGL 521 Query: 301 SKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + + K S GY PE + + +SDVY+FG++ Sbjct: 522 DKIMVQAVADEIVSQAK-SDGYKAPELHKMKKCNPRSDVYAFGIL 565 Score = 29.3 bits (64), Expect(2) = 3e-17 Identities = 13/41 (31%), Positives = 28/41 (68%), Gaps = 1/41 (2%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKN-EMILVYDYMAHGTLREHLYKTQ 131 ++RH +LV L + + K E +L+YDY+ + +L + L++++ Sbjct: 423 RIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESK 463
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 84.0 bits (206), Expect = 2e-16 Identities = 44/106 (41%), Positives = 60/106 (56%) Frame = +1 Query: 118 YTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFG 297 ++ N L W R I +G A+GL YLH +IH DVK NILLD+ + K++DFG Sbjct: 619 FSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFG 678 Query: 298 LSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 L K T + V+G+ GY+ PE+ +T K DVYS+GVV Sbjct: 679 LVKLLNRGGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVV 724
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 72.4 bits (176), Expect = 5e-13 Identities = 34/95 (35%), Positives = 58/95 (61%), Gaps = 2/95 (2%) Frame = +1 Query: 157 RLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHV 336 ++++ A++G+H+LH+ I+HRD+K+ N+LLD KW KVSDFGL+K +D Sbjct: 885 KIKMAYQASKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKT 941 Query: 337 STVVKGSFGYLDPEYFRXQXLTE--KSDVYSFGVV 435 + + G+ ++ PE + +DVYSFG++ Sbjct: 942 NDNIIGTIHWIAPEILNDSTEVDYILADVYSFGII 976 Score = 67.8 bits (164), Expect(2) = 7e-16 Identities = 37/98 (37%), Positives = 62/98 (63%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 +++ +L++ GAA G+ YLH+ + I+HRD+K NIL+DE + K++DFG ++ Sbjct: 1457 ITFANKLKLLYGAAMGIDYLHS-SNPMIVHRDIKPANILVDEHFNVKIADFGFARI--KE 1513 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+T ++ G+ + PE R + EK+DV+SFGVV Sbjct: 1514 DNTTMTRC--GTPCWTAPEVIRGEKYCEKADVFSFGVV 1549 Score = 34.3 bits (77), Expect(2) = 7e-16 Identities = 15/37 (40%), Positives = 25/37 (67%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 S+L+H ++V+ IG C +K + +V +YM G LR+ L Sbjct: 1414 SELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVL 1450
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 70.5 bits (171), Expect(2) = 3e-15 Identities = 36/104 (34%), Positives = 59/104 (56%), Gaps = 4/104 (3%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 APL W R+ I IG ++ +HYLH ++I + + NILLD+++ K++DF ++ Sbjct: 260 APLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRS 319 Query: 316 SMDHTHVSTVVKGS----FGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++H + + S Y+ EY R L+ K+DVYSFG+V Sbjct: 320 HLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIV 363 Score = 29.3 bits (64), Expect(2) = 3e-15 Identities = 12/33 (36%), Positives = 19/33 (57%) Frame = +3 Query: 21 HRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 H +++ L Y E + L+Y YM +GTL + L Sbjct: 221 HPNILELAAYFTETEKFCLIYPYMRNGTLFDRL 253
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 63.2 bits (152), Expect(2) = 4e-15 Identities = 39/110 (35%), Positives = 55/110 (50%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+S Y R + L +C+ G+ YL K +IHRD+ N L+ E V KV Sbjct: 447 CLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLE---KACVIHRDLAARNCLVGENQVIKV 503 Query: 286 SDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +T ST K + PE F + KSDV+SFGV+ Sbjct: 504 SDFGMTRFVLDDQYTS-STGTKFPVKWASPEVFSFSRYSSKSDVWSFGVL 552 Score = 36.2 bits (82), Expect(2) = 4e-15 Identities = 16/36 (44%), Positives = 23/36 (63%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL H LV L G C E+ + LV+++M HG L ++L Sbjct: 417 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYL 452
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 56.2 bits (134), Expect(2) = 5e-14 Identities = 35/100 (35%), Positives = 50/100 (50%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L+ Q L I A G+ YL A +HRD+ T N L+ E + K+ DFG+S+ Sbjct: 642 AELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY 698 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S D+ V ++ PE + T +SDV+S GVV Sbjct: 699 STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVV 738 Score = 39.7 bits (91), Expect(2) = 5e-14 Identities = 15/37 (40%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C E + +I+V++YM HG L + L Sbjct: 589 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFL 625
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 55.1 bits (131), Expect(2) = 1e-13 Identities = 34/98 (34%), Positives = 49/98 (50%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+ Q L I A G+ YL A +HRD+ T N L+ E + K+ DFG+S+ S Sbjct: 648 LTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 704 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + T +SDV+S GVV Sbjct: 705 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVV 742 Score = 39.7 bits (91), Expect(2) = 1e-13 Identities = 15/37 (40%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C E + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFL 629
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 55.1 bits (131), Expect(2) = 1e-13 Identities = 34/98 (34%), Positives = 49/98 (50%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+ Q L I A G+ YL A +HRD+ T N L+ E + K+ DFG+S+ S Sbjct: 647 LTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 703 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + T +SDV+S GVV Sbjct: 704 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVV 741 Score = 39.7 bits (91), Expect(2) = 1e-13 Identities = 15/37 (40%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C E + +I+V++YM HG L + L Sbjct: 592 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 55.1 bits (131), Expect(2) = 1e-13 Identities = 34/98 (34%), Positives = 49/98 (50%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+ Q L I A G+ YL A +HRD+ T N L+ E + K+ DFG+S+ S Sbjct: 647 LTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 703 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + T +SDV+S GVV Sbjct: 704 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVV 741 Score = 39.7 bits (91), Expect(2) = 1e-13 Identities = 15/37 (40%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C E + +I+V++YM HG L + L Sbjct: 592 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 65.1 bits (157), Expect(2) = 1e-13 Identities = 35/87 (40%), Positives = 50/87 (57%) Frame = +1 Query: 175 GAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKG 354 G A G++YLH H IIHRD+K+ N+L+ K+SDFG SK + G Sbjct: 262 GIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTKMSFAG 315 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + +L PE R + ++EK D++SFGVV Sbjct: 316 TVAWLAPEVIRNEPVSEKVDIWSFGVV 342 Score = 29.3 bits (64), Expect(2) = 1e-13 Identities = 12/36 (33%), Positives = 21/36 (58%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL+H ++++ G C + ++ +Y AHG L E L Sbjct: 210 KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 245
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 55.8 bits (133), Expect(2) = 1e-13 Identities = 34/104 (32%), Positives = 49/104 (47%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L Q L I A G+ YL A +HRD+ T N L+ + K+ DFG+S Sbjct: 647 RQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMS 703 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + S D+ V ++ PE + T +SDV+SFGV+ Sbjct: 704 RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 747 Score = 38.5 bits (88), Expect(2) = 1e-13 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 595 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 631
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 55.8 bits (133), Expect(2) = 1e-13 Identities = 34/104 (32%), Positives = 49/104 (47%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L Q L I A G+ YL A +HRD+ T N L+ + K+ DFG+S Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMS 701 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + S D+ V ++ PE + T +SDV+SFGV+ Sbjct: 702 RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 745 Score = 38.5 bits (88), Expect(2) = 1e-13 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 55.8 bits (133), Expect(2) = 1e-13 Identities = 34/104 (32%), Positives = 49/104 (47%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L Q L I A G+ YL A +HRD+ T N L+ + K+ DFG+S Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMS 701 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + S D+ V ++ PE + T +SDV+SFGV+ Sbjct: 702 RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 745 Score = 38.5 bits (88), Expect(2) = 1e-13 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 56.6 bits (135), Expect(2) = 1e-13 Identities = 29/85 (34%), Positives = 50/85 (58%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 ARG+ YL A IHRD+ N+L+ + +V K++DFGL++ S D+ +T + Sbjct: 541 ARGMDYL---ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPI 597 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + + KSDV+S+G++ Sbjct: 598 KWMAPESLQEKFYDSKSDVWSYGIL 622 Score = 37.7 bits (86), Expect(2) = 1e-13 Identities = 12/38 (31%), Positives = 25/38 (65%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 RH ++++L+G C + + ++ +Y HG L++ LYK + Sbjct: 469 RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR 506
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 73.9 bits (180), Expect = 2e-13 Identities = 41/98 (41%), Positives = 60/98 (61%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L R+RL + A+G++YLH I+HRD+K+ N+L+D+K+ KV DFGLS+ S Sbjct: 646 LDERRRLSMAYDVAKGMNYLHN-RNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKAST 704 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + S G+ ++ PE R + EKSDVYSFGV+ Sbjct: 705 FLSSKSAA--GTPEWMAPEVLRDEPSNEKSDVYSFGVI 740
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 55.5 bits (132), Expect(2) = 2e-13 Identities = 35/99 (35%), Positives = 50/99 (50%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PL Q L + A G+ YL A +HRD+ T N L+ + V K+ DFG+S+ S Sbjct: 621 PLGLGQLLAVASQVAAGMVYL---AGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS 677 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + T +SDV+SFGVV Sbjct: 678 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVV 716 Score = 38.5 bits (88), Expect(2) = 2e-13 Identities = 14/35 (40%), Positives = 22/35 (62%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 L+H+H+V G C E +++V++YM HG L L Sbjct: 567 LQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 64.3 bits (155), Expect(2) = 2e-13 Identities = 34/87 (39%), Positives = 50/87 (57%) Frame = +1 Query: 175 GAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKG 354 G A G++YLH H IIHRD+K+ N+L+ K+SDFG SK + G Sbjct: 262 GIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTKMSFAG 315 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + ++ PE R + ++EK D++SFGVV Sbjct: 316 TVAWMAPEVIRNEPVSEKVDIWSFGVV 342 Score = 29.3 bits (64), Expect(2) = 2e-13 Identities = 12/36 (33%), Positives = 21/36 (58%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL+H ++++ G C + ++ +Y AHG L E L Sbjct: 210 KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 245
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 54.7 bits (130), Expect(2) = 3e-13 Identities = 34/99 (34%), Positives = 50/99 (50%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PL Q L + A G+ YL A +HRD+ T N L+ + V K+ DFG+S+ S Sbjct: 624 PLGLGQLLAVASQVAAGMVYL---ASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS 680 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + + +SDV+SFGVV Sbjct: 681 TDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVV 719 Score = 38.5 bits (88), Expect(2) = 3e-13 Identities = 14/35 (40%), Positives = 22/35 (62%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 L+H+H+V G C E +++V++YM HG L L Sbjct: 570 LQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFL 604
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 54.3 bits (129), Expect(2) = 4e-13 Identities = 33/104 (31%), Positives = 48/104 (46%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L Q L I G+ YL A +HRD+ T N L+ + K+ DFG+S Sbjct: 645 RQAKGELGLSQMLHIASQICSGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMS 701 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + S D+ V ++ PE + T +SDV+SFGV+ Sbjct: 702 RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 745 Score = 38.5 bits (88), Expect(2) = 4e-13 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 53.5 bits (127), Expect(2) = 4e-13 Identities = 33/98 (33%), Positives = 49/98 (50%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+ L+I A G+ YL A +HRD+ T N L+ V K+ DFG+S+ S Sbjct: 605 LTLSHMLQIATQIASGMVYL---ASLHFVHRDLATRNCLVGHDLVVKIGDFGMSRDIYST 661 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + T +SD++SFGVV Sbjct: 662 DYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVV 699 Score = 39.3 bits (90), Expect(2) = 4e-13 Identities = 15/35 (42%), Positives = 22/35 (62%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 L+H H+V G C E + +I+V++YM HG L L Sbjct: 550 LQHEHIVKFYGVCTEGDPLIMVFEYMKHGDLNRFL 584
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 63.2 bits (152), Expect(2) = 8e-13 Identities = 39/106 (36%), Positives = 57/106 (53%), Gaps = 13/106 (12%) Frame = +1 Query: 157 RLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLD-------------EKWVAKVSDFG 297 RL++ + A+G++YLH G I+HRD+ + NILLD + K+SDFG Sbjct: 1392 RLKLALDIAKGMNYLH-GWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFG 1450 Query: 298 LSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 LS+ +V G Y+ PE F+ +EKSDVYS+G+V Sbjct: 1451 LSRLKKEQASQMTQSV--GCIPYMAPEVFKGDSNSEKSDVYSYGMV 1494 Score = 28.5 bits (62), Expect(2) = 8e-13 Identities = 15/39 (38%), Positives = 23/39 (58%), Gaps = 2/39 (5%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNE--MILVYDYMAHGTLREHL 119 SKLRH ++V +G C E +V ++M G+LR+ L Sbjct: 1340 SKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFL 1378
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 58.2 bits (139), Expect(2) = 8e-13 Identities = 38/113 (33%), Positives = 60/113 (53%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 ME C + TR LS++ + ARG+ YL A IHRD+ N+L+ E V Sbjct: 579 MEYCYNP-TRIPEEQLSFKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTEDNV 634 Query: 277 AKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K++DFGL++ +D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 635 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 687 Score = 33.5 bits (75), Expect(2) = 8e-13 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 538 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 571
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 63.2 bits (152), Expect(2) = 8e-13 Identities = 39/104 (37%), Positives = 56/104 (53%), Gaps = 5/104 (4%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILL---DEKWVAKVSDFGLSKT 309 PLSW RL + + ARGL YLH+ + HRD+ + N L+ D + A V DFGL++ Sbjct: 146 PLSWPVRLHLALDIARGLRYLHSKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEK 202 Query: 310 GPSMDH--THVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 P V GS ++ PE R + EK+DV++FG+V Sbjct: 203 IPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIV 246 Score = 28.5 bits (62), Expect(2) = 8e-13 Identities = 11/37 (29%), Positives = 23/37 (62%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++LRH +++ +G C + ++ + +YM GTL + L Sbjct: 105 NRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL 141
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 52.8 bits (125), Expect(2) = 1e-12 Identities = 32/98 (32%), Positives = 47/98 (47%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L Q L I A G+ YL A +HRD+ T N + + K+ DFG+S+ S Sbjct: 651 LGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCXVGANLLVKIGDFGMSRDVYST 707 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V ++ PE + T +SDV+SFGV+ Sbjct: 708 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 745 Score = 38.5 bits (88), Expect(2) = 1e-12 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) Length = 800 Score = 55.5 bits (132), Expect(2) = 1e-12 Identities = 32/104 (30%), Positives = 55/104 (52%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R PLS+ + ARG+ YL + IHRD+ N+L+ E V K++DFGL+ Sbjct: 576 RSSEGPLSFPALVSCAYQVARGMQYLES---RKCIHRDLAARNVLVTEDDVMKIADFGLA 632 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + +D+ ++ + ++ PE + T +SDV+SFG++ Sbjct: 633 RGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGIL 676 Score = 35.8 bits (81), Expect(2) = 1e-12 Identities = 12/34 (35%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 RH+++++L+G C ++ + ++ +Y A G LRE L Sbjct: 527 RHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFL 560
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (CD333 antigen) Length = 806 Score = 58.5 bits (140), Expect(2) = 1e-12 Identities = 33/104 (31%), Positives = 57/104 (54%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 +P L+++ + ARG+ YL A IHRD+ N+L+ E V K++DFGL+ Sbjct: 583 KPPEEQLTFKDLVSCAYQVARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLA 639 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + ++D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 640 RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683 Score = 32.3 bits (72), Expect(2) = 1e-12 Identities = 11/34 (32%), Positives = 23/34 (67%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y A G LRE L Sbjct: 534 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 49.7 bits (117), Expect(2) = 2e-12 Identities = 27/103 (26%), Positives = 50/103 (48%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P + Q + + + G+ YL + ++HRD++ NIL+ KV+DFGL++ Sbjct: 309 PDGKKTNLNQMVHMMAEISEGMAYLES---EKVVHRDLRADNILVANDLTRKVADFGLTE 365 Query: 307 TGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ + + PE + + T KSDV+S+G+V Sbjct: 366 LTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIV 408 Score = 40.4 bits (93), Expect(2) = 2e-12 Identities = 17/38 (44%), Positives = 28/38 (73%), Gaps = 2/38 (5%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNE--MILVYDYMAHGTLREHL 119 KLRHR +V L+G C E + M+++ +YM +G+L+E+L Sbjct: 269 KLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYL 306
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 57.0 bits (136), Expect(2) = 3e-12 Identities = 35/98 (35%), Positives = 53/98 (54%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS + L+I + + G+ YL + H +HRD+ N L++E V K+SDFGLS+ S Sbjct: 511 LSQLEFLQIALQISEGMQYL---SAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSS 567 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ V + ++ E T +SDV+SFGVV Sbjct: 568 DYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVV 605 Score = 32.7 bits (73), Expect(2) = 3e-12 Identities = 13/37 (35%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 S L+H+++V ++G K ++++YMA+G L E L Sbjct: 464 SDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFL 500
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 61.2 bits (147), Expect(2) = 3e-12 Identities = 38/104 (36%), Positives = 55/104 (52%), Gaps = 5/104 (4%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILL---DEKWVAKVSDFGLSKT 309 PLSW RL + + A+GL YLH + HRD+ + N L+ D + A V DFGL++ Sbjct: 141 PLSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEK 197 Query: 310 GPSMDH--THVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 P V GS ++ PE R + EK+DV++FG+V Sbjct: 198 IPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIV 241 Score = 28.5 bits (62), Expect(2) = 3e-12 Identities = 11/37 (29%), Positives = 23/37 (62%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++LRH +++ +G C + ++ + +YM GTL + L Sbjct: 100 NRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL 136
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 59.3 bits (142), Expect(2) = 3e-12 Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 6/104 (5%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK---TG 312 ++W R I A G++YLH ++H D+KT NILLD ++ K++DFGLSK Sbjct: 116 IAWPLRFRILHEIALGVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMS 174 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYF---RXQXLTEKSDVYSFGVV 435 S ++ S G+ Y+ PE + + + K D+YS+ V+ Sbjct: 175 LSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVI 218 Score = 30.4 bits (67), Expect(2) = 3e-12 Identities = 12/38 (31%), Positives = 24/38 (63%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 K R +++ ++G C E + +V +YM +G+L E L++ Sbjct: 72 KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHR 109
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) Length = 812 Score = 55.8 bits (133), Expect(2) = 4e-12 Identities = 36/113 (31%), Positives = 59/113 (52%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 ME C + P LS++ + ARG+ YL A IHRD+ N+L+ E + Sbjct: 575 MEYCYNPTCVPDQL-LSFKDLVSCAYQVARGMDYL---ASKKCIHRDLAARNVLVTEDNI 630 Query: 277 AKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K++DFGL++ +D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 631 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 683 Score = 33.5 bits (75), Expect(2) = 4e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 534 KHKNIINLLGACTQDGPLYVIVEYTSKGNLREYL 567
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 53.1 bits (126), Expect(2) = 4e-12 Identities = 31/92 (33%), Positives = 50/92 (54%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L++CI ++G+ YL +H IHRD+ N L+ + V KV+DFGL++ +T S Sbjct: 625 LDMCIQVSKGMTYLE---RHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTS-S 680 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + PE + KSDV+++GV+ Sbjct: 681 GGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVL 712 Score = 36.2 bits (82), Expect(2) = 4e-12 Identities = 15/37 (40%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +KL+H +LV L G C + + +V +YM HG+L +L Sbjct: 574 TKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYL 610
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 57.4 bits (137), Expect(2) = 5e-12 Identities = 35/103 (33%), Positives = 54/103 (52%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P PLS ++L I A G+ YL ++ +HRD+ T N L+ E V K++DFGLS+ Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYL---SERKFVHRDLATRNCLVGENMVVKIADFGLSR 748 Query: 307 TGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S D+ + ++ PE T +SDV+++GVV Sbjct: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVV 791 Score = 31.6 bits (70), Expect(2) = 5e-12 Identities = 13/31 (41%), Positives = 20/31 (64%) Frame = +3 Query: 27 HLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++V L+G C M L+++YMA+G L E L Sbjct: 637 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL 667
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 56.2 bits (134), Expect(2) = 5e-12 Identities = 32/98 (32%), Positives = 55/98 (56%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+++ + ARG+ YL A IHRD+ N+L+ E V K++DFGL++ ++ Sbjct: 583 LTFKDLVSCAYQVARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNI 639 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 640 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 677 Score = 32.7 bits (73), Expect(2) = 5e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 528 KHKNIINLLGACTQDGPLYVLVEYASKGNLREYL 561
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 60.5 bits (145), Expect(2) = 5e-12 Identities = 38/104 (36%), Positives = 55/104 (52%), Gaps = 5/104 (4%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILL---DEKWVAKVSDFGLSKT 309 PLSW RL + + A+GL YLH + HRD+ + N L+ D + A V DFGL++ Sbjct: 141 PLSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCLVRREDGGFTAVVGDFGLAEK 197 Query: 310 GPSMDH--THVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 P V GS ++ PE R + EK+DV++FG+V Sbjct: 198 IPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIV 241 Score = 28.5 bits (62), Expect(2) = 5e-12 Identities = 11/37 (29%), Positives = 23/37 (62%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++LRH +++ +G C + ++ + +YM GTL + L Sbjct: 100 NRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL 136
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 54.3 bits (129), Expect(2) = 7e-12 Identities = 37/103 (35%), Positives = 53/103 (51%), Gaps = 5/103 (4%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS +Q L ARG+ YL ++ IHRD+ NIL+ E +VAK++DFGLS+ Sbjct: 937 LSSQQLLHFAADVARGMDYL---SQKQFIHRDLAARNILVGENYVAKIADFGLSR----- 988 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 VK + G L + + L T SDV+S+GV+ Sbjct: 989 ---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVL 1028 Score = 34.3 bits (77), Expect(2) = 7e-12 Identities = 13/42 (30%), Positives = 24/42 (57%) Frame = +3 Query: 6 CSKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 C H ++++L+G CE + + L +Y HG L + L K++ Sbjct: 878 CKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR 919
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 54.3 bits (129), Expect(2) = 7e-12 Identities = 37/103 (35%), Positives = 53/103 (51%), Gaps = 5/103 (4%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS +Q L ARG+ YL ++ IHRD+ NIL+ E +VAK++DFGLS+ Sbjct: 936 LSSQQLLHFAADVARGMDYL---SQKQFIHRDLAARNILVGENYVAKIADFGLSR----- 987 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 VK + G L + + L T SDV+S+GV+ Sbjct: 988 ---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVL 1027 Score = 34.3 bits (77), Expect(2) = 7e-12 Identities = 13/42 (30%), Positives = 24/42 (57%) Frame = +3 Query: 6 CSKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 C H ++++L+G CE + + L +Y HG L + L K++ Sbjct: 877 CKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR 918
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 64.7 bits (156), Expect(2) = 7e-12 Identities = 35/88 (39%), Positives = 52/88 (59%) Frame = +1 Query: 172 IGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVK 351 +G A G++YLH H IIHRD+K+ N+L+ V K+SDFG SK + Sbjct: 251 MGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFA 304 Query: 352 GSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G+ ++ PE R + ++EK D++SFGVV Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVV 332 Score = 23.9 bits (50), Expect(2) = 7e-12 Identities = 10/36 (27%), Positives = 20/36 (55%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL+H ++++ G C + ++ ++ A G L E L Sbjct: 200 KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL 235
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 64.7 bits (156), Expect(2) = 7e-12 Identities = 35/88 (39%), Positives = 52/88 (59%) Frame = +1 Query: 172 IGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVK 351 +G A G++YLH H IIHRD+K+ N+L+ V K+SDFG SK + Sbjct: 251 MGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFA 304 Query: 352 GSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G+ ++ PE R + ++EK D++SFGVV Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVV 332 Score = 23.9 bits (50), Expect(2) = 7e-12 Identities = 10/36 (27%), Positives = 20/36 (55%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL+H ++++ G C + ++ ++ A G L E L Sbjct: 200 KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL 235
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 64.7 bits (156), Expect(2) = 7e-12 Identities = 35/88 (39%), Positives = 52/88 (59%) Frame = +1 Query: 172 IGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVK 351 +G A G++YLH H IIHRD+K+ N+L+ V K+SDFG SK + Sbjct: 218 MGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFA 271 Query: 352 GSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G+ ++ PE R + ++EK D++SFGVV Sbjct: 272 GTVAWMAPEVIRNEPVSEKVDIWSFGVV 299 Score = 23.9 bits (50), Expect(2) = 7e-12 Identities = 10/36 (27%), Positives = 20/36 (55%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL+H ++++ G C + ++ ++ A G L E L Sbjct: 167 KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL 202
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 55.1 bits (131), Expect(2) = 7e-12 Identities = 31/85 (36%), Positives = 50/85 (58%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 ARG+ YL A IHRD+ N+L+ E V K++DFGL++ ++D+ +T + Sbjct: 613 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 669 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + T +SDV+SFGV+ Sbjct: 670 KWMAPEALFDRVYTHQSDVWSFGVL 694 Score = 33.5 bits (75), Expect(2) = 7e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 545 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 578
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 55.1 bits (131), Expect(2) = 7e-12 Identities = 31/85 (36%), Positives = 50/85 (58%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 ARG+ YL A IHRD+ N+L+ E V K++DFGL++ ++D+ +T + Sbjct: 611 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 667 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + T +SDV+SFGV+ Sbjct: 668 KWMAPEALFDRVYTHQSDVWSFGVL 692 Score = 33.5 bits (75), Expect(2) = 7e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 543 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 576
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 55.1 bits (131), Expect(2) = 7e-12 Identities = 31/85 (36%), Positives = 50/85 (58%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 ARG+ YL A IHRD+ N+L+ E V K++DFGL++ ++D+ +T + Sbjct: 611 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 667 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + T +SDV+SFGV+ Sbjct: 668 KWMAPEALFDRVYTHQSDVWSFGVL 692 Score = 33.5 bits (75), Expect(2) = 7e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 543 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 576
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 55.5 bits (132), Expect(2) = 7e-12 Identities = 32/105 (30%), Positives = 58/105 (55%) Frame = +1 Query: 121 TRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 TR + ++++ + ARG+ YL A IHRD+ N+L+ E V K++DFGL Sbjct: 581 TRVPDEQMTFKDLVSCTYQIARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGL 637 Query: 301 SKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ ++D+ ++ + ++ PE + T +SDV+SFGV+ Sbjct: 638 ARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 682 Score = 33.1 bits (74), Expect(2) = 7e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y A G LR++L Sbjct: 533 KHKNIINLLGACTQGGTLYVIVEYAAKGNLRQYL 566
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 56.6 bits (135), Expect(2) = 7e-12 Identities = 35/111 (31%), Positives = 56/111 (50%), Gaps = 1/111 (0%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ Y R +Q LE+C + YL + +HRD+ N L++++ V KV Sbjct: 480 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES---KQFLHRDLAARNCLVNDQGVVKV 536 Query: 286 SDFGLSKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFGLS+ +D + S+V K + PE + KSD+++FGV+ Sbjct: 537 SDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVL 585 Score = 32.0 bits (71), Expect(2) = 7e-12 Identities = 13/35 (37%), Positives = 21/35 (60%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 L H LV L G C ++ + ++ +YMA+G L +L Sbjct: 451 LSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYL 485
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 56.6 bits (135), Expect(2) = 7e-12 Identities = 35/111 (31%), Positives = 56/111 (50%), Gaps = 1/111 (0%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ Y R +Q LE+C + YL + +HRD+ N L++++ V KV Sbjct: 480 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES---KQFLHRDLAARNCLVNDQGVVKV 536 Query: 286 SDFGLSKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFGLS+ +D + S+V K + PE + KSD+++FGV+ Sbjct: 537 SDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVL 585 Score = 32.0 bits (71), Expect(2) = 7e-12 Identities = 13/35 (37%), Positives = 21/35 (60%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 L H LV L G C ++ + ++ +YMA+G L +L Sbjct: 451 LSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYL 485
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 53.9 bits (128), Expect(2) = 9e-12 Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 5/103 (4%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS +Q L ARG+ YL ++ IHRD+ NIL+ E ++AK++DFGLS+ Sbjct: 934 LSSQQLLHFAADVARGMDYL---SQKQFIHRDLAARNILVGENYIAKIADFGLSR----- 985 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 VK + G L + + L T SDV+S+GV+ Sbjct: 986 ---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVL 1025 Score = 34.3 bits (77), Expect(2) = 9e-12 Identities = 13/42 (30%), Positives = 24/42 (57%) Frame = +3 Query: 6 CSKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 C H ++++L+G CE + + L +Y HG L + L K++ Sbjct: 875 CKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR 916
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 56.6 bits (135), Expect(2) = 9e-12 Identities = 35/103 (33%), Positives = 53/103 (51%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P PLS ++L I A G+ YL ++ +HRD+ T N L+ E V K++DFGLS+ Sbjct: 691 PGPPPLSCAEQLCIARQVAAGMAYL---SERKFVHRDLATRNCLVGENMVVKIADFGLSR 747 Query: 307 TGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S D+ ++ PE T +SDV+++GVV Sbjct: 748 NIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVV 790 Score = 31.6 bits (70), Expect(2) = 9e-12 Identities = 13/31 (41%), Positives = 20/31 (64%) Frame = +3 Query: 27 HLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++V L+G C M L+++YMA+G L E L Sbjct: 636 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL 666
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 54.7 bits (130), Expect(2) = 9e-12 Identities = 36/113 (31%), Positives = 58/113 (51%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 +E C + P LS + + ARG+ YL A IHRD+ N+L+ E V Sbjct: 581 LEYCYNPSHNPEEQ-LSSKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTEDNV 636 Query: 277 AKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K++DFGL++ +D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689 Score = 33.5 bits (75), Expect(2) = 9e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 573
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 54.7 bits (130), Expect(2) = 9e-12 Identities = 36/113 (31%), Positives = 58/113 (51%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 +E C + P LS + + ARG+ YL A IHRD+ N+L+ E V Sbjct: 581 LEYCYNPSHNPEEQ-LSSKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTEDNV 636 Query: 277 AKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K++DFGL++ +D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689 Score = 33.5 bits (75), Expect(2) = 9e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 573
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 54.7 bits (130), Expect(2) = 9e-12 Identities = 36/113 (31%), Positives = 58/113 (51%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 +E C + P LS + + ARG+ YL A IHRD+ N+L+ E V Sbjct: 581 LEYCYNPSHNPEEQ-LSSKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTEDNV 636 Query: 277 AKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K++DFGL++ +D+ +T + ++ PE + T +SDV+SFGV+ Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689 Score = 33.5 bits (75), Expect(2) = 9e-12 Identities = 10/34 (29%), Positives = 24/34 (70%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y + G LRE+L Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 573
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 56.2 bits (134), Expect(2) = 9e-12 Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 3/102 (2%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSD--FGLSKTG 312 PL W QR+ IC G + YLH G + IIH +VK++N+LLD+ K++ L Sbjct: 306 PLPWPQRVSICSGLLCAVEYLH-GLE--IIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVN 362 Query: 313 PSMDHTHVST-VVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +T + T +++ S YL ++ R LT++ D++S G+V Sbjct: 363 KRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIV 404 Score = 32.0 bits (71), Expect(2) = 9e-12 Identities = 11/38 (28%), Positives = 24/38 (63%) Frame = +3 Query: 6 CSKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 C + H +++ ++G+C + +Y YMA+G+L++ L Sbjct: 261 CLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRL 298
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 56.6 bits (135), Expect(2) = 9e-12 Identities = 36/85 (42%), Positives = 46/85 (54%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L YLH K +IHRD+K NILL K+SDFG S PS + T + G+ Sbjct: 197 ANALSYLH---KKHVIHRDIKPENILLGIDGEIKLSDFGWSVHAPS----NRRTTLCGTL 249 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE + TEK D++S GV+ Sbjct: 250 DYLPPEMVEGKEHTEKVDLWSLGVL 274 Score = 31.6 bits (70), Expect(2) = 9e-12 Identities = 11/41 (26%), Positives = 25/41 (60%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 S LRH++++ L G+ ++ + L+ ++ G L +HL + + Sbjct: 142 SNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAK 182
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 56.2 bits (134), Expect(2) = 1e-11 Identities = 35/103 (33%), Positives = 53/103 (51%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P PLS ++L I A G+ YL ++ +HRD+ T N L+ E V K++DFGLS+ Sbjct: 691 PGPPPLSCAEQLCIARQVAAGMAYL---SERKFVHRDLATRNCLVGETMVVKIADFGLSR 747 Query: 307 TGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S D+ ++ PE T +SDV+++GVV Sbjct: 748 NIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVV 790 Score = 31.6 bits (70), Expect(2) = 1e-11 Identities = 13/31 (41%), Positives = 20/31 (64%) Frame = +3 Query: 27 HLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++V L+G C M L+++YMA+G L E L Sbjct: 636 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL 666
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 55.5 bits (132), Expect(2) = 1e-11 Identities = 31/85 (36%), Positives = 50/85 (58%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 ARG+ YL A IHRD+ N+L+ E V K++DFGL++ ++D+ +T + Sbjct: 596 ARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 652 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + T +SDV+SFGV+ Sbjct: 653 KWMAPEALFDRVYTHQSDVWSFGVL 677 Score = 32.3 bits (72), Expect(2) = 1e-11 Identities = 11/34 (32%), Positives = 23/34 (67%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +H+++++L+G C + + ++ +Y A G LRE L Sbjct: 528 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 561
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (CD334 antigen) Length = 802 Score = 55.1 bits (131), Expect(2) = 1e-11 Identities = 32/104 (30%), Positives = 55/104 (52%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R PLS+ + ARG+ YL + IHRD+ N+L+ E V K++DFGL+ Sbjct: 578 RSSEGPLSFPVLVSCAYQVARGMQYLES---RKCIHRDLAARNVLVTEDNVMKIADFGLA 634 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + +D+ ++ + ++ PE + T +SDV+SFG++ Sbjct: 635 RGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGIL 678 Score = 32.3 bits (72), Expect(2) = 1e-11 Identities = 11/34 (32%), Positives = 23/34 (67%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 RH+++++L+G C ++ + ++ + A G LRE L Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFL 562
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 57.0 bits (136), Expect(2) = 1e-11 Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 6/104 (5%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK---TG 312 ++W R I A G++YLH ++H D+KT NILLD ++ K++DFGLSK Sbjct: 116 VAWPLRFRILHEIALGVNYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMS 174 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYF---RXQXLTEKSDVYSFGVV 435 S + S G+ Y+ PE + + + K D+YS+ V+ Sbjct: 175 LSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 218 Score = 30.4 bits (67), Expect(2) = 1e-11 Identities = 12/38 (31%), Positives = 24/38 (63%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 K R +++ ++G C E + +V +YM +G+L E L++ Sbjct: 72 KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHR 109
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 67.4 bits (163), Expect = 1e-11 Identities = 36/104 (34%), Positives = 58/104 (55%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R PL ++ +EI R L + H K+ IIHRD+K NIL+ ++ V KV+DFG++ Sbjct: 100 RENGGPLEVKRAVEIASQVCRALDHAH---KNKIIHRDIKPQNILVTDEDVVKVTDFGIA 156 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + T+ V+ G+ Y PE + + E++D+YS G+V Sbjct: 157 RAANGATITYTGDVI-GTAYYFSPEQAKGSIVDERTDIYSLGIV 199
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 53.1 bits (126), Expect(2) = 1e-11 Identities = 31/92 (33%), Positives = 47/92 (51%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L+ + + YL + +HRD+ N+L+ E +AKVSDFGL+K S T Sbjct: 292 LKFSLDVCEAMEYLEA---NNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTG-- 346 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + PE R + + KSDV+SFG++ Sbjct: 347 ---KLPVKWTAPEALREKKFSTKSDVWSFGIL 375 Score = 34.3 bits (77), Expect(2) = 1e-11 Identities = 17/38 (44%), Positives = 28/38 (73%), Gaps = 1/38 (2%) Frame = +3 Query: 9 SKLRHRHLVSLIGYC-EEKNEMILVYDYMAHGTLREHL 119 ++LRH +LV L+G EEK+ + +V +YMA G+L ++L Sbjct: 241 TQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYL 278
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 48.5 bits (114), Expect(2) = 2e-11 Identities = 34/118 (28%), Positives = 50/118 (42%), Gaps = 14/118 (11%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L Q L I A G+ YL A +HRD+ T N L+ + K+ DFG+S Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMS 701 Query: 304 KTGPSMDHTHVSTVVKGSF--------------GYLDPEYFRXQXLTEKSDVYSFGVV 435 + S D+ + F ++ PE + T +SDV+SFGV+ Sbjct: 702 RDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 759 Score = 38.5 bits (88), Expect(2) = 2e-11 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 54.7 bits (130), Expect(2) = 2e-11 Identities = 42/115 (36%), Positives = 60/115 (52%), Gaps = 14/115 (12%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL---- 300 + PLS + R I + A G+ YLH +IH+D+K NIL+D + K++D G+ Sbjct: 109 DVPLSLKGR--IIVEAIEGMCYLHDKG---VIHKDLKPENILVDRDFHIKIADLGVASFK 163 Query: 301 --SKTGPSMDH--THVSTVVK----GSFGYLDPEYFR--XQXLTEKSDVYSFGVV 435 SK D+ VS+ K G+ Y+ PE+ TEKSDVYSFG+V Sbjct: 164 TWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIV 218 Score = 32.3 bits (72), Expect(2) = 2e-11 Identities = 17/40 (42%), Positives = 23/40 (57%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 +LRH +V L+G E+ LV +YM G L H+ KTQ Sbjct: 69 RLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLM-HVLKTQ 107
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 47.0 bits (110), Expect(2) = 2e-11 Identities = 29/92 (31%), Positives = 47/92 (51%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 +++ A G+ +L IHRD+ NIL+ E ++ KV+DFGL++ ++T Sbjct: 338 IDMAAQVASGMAFLEAQG---YIHRDLAARNILVGENYICKVADFGLARLIEDDEYT-AH 393 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + PE T KSDV+SFG++ Sbjct: 394 EGAKFPIKWTAPEAALYNRFTIKSDVWSFGIL 425 Score = 39.7 bits (91), Expect(2) = 2e-11 Identities = 16/38 (42%), Positives = 26/38 (68%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 KLRH+HLV L C ++ + +V +YM+ G+L ++L K Sbjct: 289 KLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSK 326
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 52.8 bits (125), Expect(2) = 2e-11 Identities = 32/92 (34%), Positives = 47/92 (51%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L+ + + YL + +HRD+ N+L+ E VAKVSDFGL+K S T Sbjct: 292 LKFSLDVCEAMEYLEG---NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-- 346 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + PE R + + KSDV+SFG++ Sbjct: 347 ---KLPVKWTAPEALREKKFSTKSDVWSFGIL 375 Score = 33.9 bits (76), Expect(2) = 2e-11 Identities = 17/38 (44%), Positives = 27/38 (71%), Gaps = 1/38 (2%) Frame = +3 Query: 9 SKLRHRHLVSLIGYC-EEKNEMILVYDYMAHGTLREHL 119 ++LRH +LV L+G EEK + +V +YMA G+L ++L Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 52.8 bits (125), Expect(2) = 2e-11 Identities = 32/92 (34%), Positives = 47/92 (51%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L+ + + YL + +HRD+ N+L+ E VAKVSDFGL+K S T Sbjct: 292 LKFSLDVCEAMEYLEG---NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-- 346 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + PE R + + KSDV+SFG++ Sbjct: 347 ---KLPVKWTAPEALREKKFSTKSDVWSFGIL 375 Score = 33.9 bits (76), Expect(2) = 2e-11 Identities = 17/38 (44%), Positives = 27/38 (71%), Gaps = 1/38 (2%) Frame = +3 Query: 9 SKLRHRHLVSLIGYC-EEKNEMILVYDYMAHGTLREHL 119 ++LRH +LV L+G EEK + +V +YMA G+L ++L Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 66.6 bits (161), Expect = 3e-11 Identities = 38/101 (37%), Positives = 57/101 (56%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 N PL ++ L I + + H ++ I+HRD+K NIL+D KV+DFG++ Sbjct: 103 NGPLHPKEALNIMEQIVSAIAHAH---QNQIVHRDIKPHNILIDHMGNIKVTDFGIATAL 159 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S TH ++V+ GS YL PE R T+KSD+Y+ G+V Sbjct: 160 SSTTITHTNSVL-GSVHYLSPEQARGGLATKKSDIYALGIV 199
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 52.4 bits (124), Expect(2) = 3e-11 Identities = 32/92 (34%), Positives = 47/92 (51%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L+ + + YL + +HRD+ N+L+ E VAKVSDFGL+K S T Sbjct: 292 LKFSLDVLEAMEYLEG---NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-- 346 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 K + PE R + + KSDV+SFG++ Sbjct: 347 ---KLPVKWTAPEALREKKFSTKSDVWSFGIL 375 Score = 33.9 bits (76), Expect(2) = 3e-11 Identities = 17/38 (44%), Positives = 27/38 (71%), Gaps = 1/38 (2%) Frame = +3 Query: 9 SKLRHRHLVSLIGYC-EEKNEMILVYDYMAHGTLREHL 119 ++LRH +LV L+G EEK + +V +YMA G+L ++L Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 53.1 bits (126), Expect(2) = 4e-11 Identities = 33/101 (32%), Positives = 53/101 (52%), Gaps = 2/101 (1%) Frame = +1 Query: 139 PLSWRQRLEICIG--AARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 PL+ ++CI A G+ YL ++ +HRD+ T N L+ E V K++DFGLS+ Sbjct: 772 PLALCCTSQLCIAKQVAAGMAYL---SERKFVHRDLATRNCLVGENMVVKIADFGLSRNM 828 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S D+ + ++ PE T +SDV+++GVV Sbjct: 829 YSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVV 869 Score = 32.7 bits (73), Expect(2) = 4e-11 Identities = 13/31 (41%), Positives = 21/31 (67%) Frame = +3 Query: 27 HLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++V L+G C M L+++YMA+G L E+L Sbjct: 717 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEYL 747
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 62.0 bits (149), Expect(2) = 5e-11 Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 8/96 (8%) Frame = +1 Query: 172 IGAARGLHYLHTGAKHTIIHRDVKTTNILLDE--------KWVAKVSDFGLSKTGPSMDH 327 + ARG++YLH A IIHRD+K+ NIL+ E V K++DFGL++ H Sbjct: 201 VQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW----H 256 Query: 328 THVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G++ ++ PE R ++ SDV+SFGV+ Sbjct: 257 KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVL 292 Score = 23.5 bits (49), Expect(2) = 5e-11 Identities = 10/31 (32%), Positives = 17/31 (54%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 L+H ++++L G C + LV +Y G L Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGAL 182
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 53.9 bits (128), Expect(2) = 7e-11 Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 5/103 (4%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS RQ L AA G+ YL ++ IHRD+ N+L+ E +K++DFGLS+ Sbjct: 949 LSSRQLLRFASDAANGMQYL---SEKQFIHRDLAARNVLVGENLASKIADFGLSR----- 1000 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 VK + G L + + L T KSDV+SFGV+ Sbjct: 1001 ---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVL 1040 Score = 31.2 bits (69), Expect(2) = 7e-11 Identities = 11/42 (26%), Positives = 24/42 (57%) Frame = +3 Query: 6 CSKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 C H ++++L+G CE + + + +Y +G L + L K++ Sbjct: 890 CKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSR 931
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 53.9 bits (128), Expect(2) = 7e-11 Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 5/103 (4%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS RQ L AA G+ YL ++ IHRD+ N+L+ E +K++DFGLS+ Sbjct: 947 LSSRQLLRFASDAANGMQYL---SEKQFIHRDLAARNVLVGENLASKIADFGLSR----- 998 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 VK + G L + + L T KSDV+SFGV+ Sbjct: 999 ---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVL 1038 Score = 31.2 bits (69), Expect(2) = 7e-11 Identities = 11/42 (26%), Positives = 24/42 (57%) Frame = +3 Query: 6 CSKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 C H ++++L+G CE + + + +Y +G L + L K++ Sbjct: 888 CKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSR 929
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 56.2 bits (134), Expect(2) = 7e-11 Identities = 32/92 (34%), Positives = 48/92 (52%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L I I A G+ YL + H +H+D+ NIL+ E+ K+SD GLS+ S D+ V Sbjct: 593 LHIAIQIAAGMEYL---SSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQ 649 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + ++ PE + SD++SFGVV Sbjct: 650 SKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVV 681 Score = 28.9 bits (63), Expect(2) = 7e-11 Identities = 11/37 (29%), Positives = 23/37 (62%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++L H ++V L+G ++ + ++++YM G L E L Sbjct: 528 AELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFL 564
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 65.1 bits (157), Expect = 7e-11 Identities = 36/97 (37%), Positives = 51/97 (52%), Gaps = 6/97 (6%) Frame = +1 Query: 163 EICIGAARGLHYLH------TGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMD 324 ++ AA GL Y H TG +IHRDV NIL+ + KV DFG++K Sbjct: 113 KVVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKVVDFGIAKVA-GQG 171 Query: 325 HTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 H ++ VVKG Y+ PE + + + + DVY+ GVV Sbjct: 172 HRTLTGVVKGKVAYMPPEQLQAKAMDRRVDVYALGVV 208
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 52.4 bits (124), Expect(2) = 9e-11 Identities = 31/104 (29%), Positives = 54/104 (51%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R PLS+ + ARG+ YL + IHRD+ N+L+ E V K++DFGL+ Sbjct: 575 RSSEGPLSFPALVSCAYQVARGMQYLES---RKCIHRDLAARNVLVTEDDVMKIADFGLA 631 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + +D+ ++ + ++ PE + T +SDV+SF ++ Sbjct: 632 RGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEIL 675 Score = 32.3 bits (72), Expect(2) = 9e-11 Identities = 11/34 (32%), Positives = 23/34 (67%) Frame = +3 Query: 18 RHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 RH+++++L+G C ++ + ++ + A G LRE L Sbjct: 526 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFL 559
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 55.1 bits (131), Expect(2) = 9e-11 Identities = 35/102 (34%), Positives = 55/102 (53%), Gaps = 4/102 (3%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK-TGPS 318 L W +L I + +++LH+ K ++H D+K NILLD K+SDFGLSK S Sbjct: 127 LCWPLKLRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQS 185 Query: 319 MDHTHVS-TVVKGSFGYLDPEYF--RXQXLTEKSDVYSFGVV 435 ++ + ++G+ Y+ PE F + + DVYSF +V Sbjct: 186 TQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIV 227 Score = 29.6 bits (65), Expect(2) = 9e-11 Identities = 14/42 (33%), Positives = 25/42 (59%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXC 137 K++ +H+VS+ G C K + +V ++MA G+L + L C Sbjct: 89 KIKFQHIVSIYGVC--KQPLGIVMEFMASGSLEKTLPTHSLC 128
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 64.7 bits (156), Expect = 1e-10 Identities = 36/101 (35%), Positives = 54/101 (53%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 NAPL+ + +EI + H+ H IIHRD+K N+L+ KV+DFG++K Sbjct: 105 NAPLANDEAIEIITEILSAMDMAHS---HGIIHRDLKPQNVLVSSSGTVKVTDFGIAKAL 161 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 T +T+ GS YL PE R T +SD+Y+ G++ Sbjct: 162 SETSLTQTNTMF-GSVHYLSPEQARGSNATVQSDIYAIGII 201
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 64.7 bits (156), Expect = 1e-10 Identities = 41/102 (40%), Positives = 54/102 (52%), Gaps = 3/102 (2%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK-TGP 315 PL W R I A G+++LH A ++H D+K NILLD + K+SDFGL+K G Sbjct: 112 PLPWDLRFRIIHETAVGMNFLHCMAP-PLLHLDLKPANILLDAHYHVKISDFGLAKCNGL 170 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFR--XQXLTEKSDVYSFGVV 435 S H + G+ YL PE R + K DVYSF +V Sbjct: 171 SHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIV 212
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 64.3 bits (155), Expect = 1e-10 Identities = 34/85 (40%), Positives = 52/85 (61%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A+G+HYLH A +IHRD+K+ N+++ V K+ DFG S+ TH+S V G+F Sbjct: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF--HNHTTHMSLV--GTF 170 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + ++E D YS+GVV Sbjct: 171 PWMAPEVIQSLPVSETCDTYSYGVV 195
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 64.3 bits (155), Expect = 1e-10 Identities = 34/85 (40%), Positives = 52/85 (61%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A+G+HYLH A +IHRD+K+ N+++ V K+ DFG S+ TH+S V G+F Sbjct: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF--HNHTTHMSLV--GTF 170 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + ++E D YS+GVV Sbjct: 171 PWMAPEVIQSLPVSETCDTYSYGVV 195
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 59.7 bits (143), Expect(2) = 2e-10 Identities = 33/93 (35%), Positives = 54/93 (58%), Gaps = 8/93 (8%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEK--------WVAKVSDFGLSKTGPSMDHTHV 336 ARG++YLH A IIHRD+K++NIL+ +K + K++DFGL++ H Sbjct: 250 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW----HRTT 305 Query: 337 STVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G++ ++ PE R ++ SDV+S+GV+ Sbjct: 306 KMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVL 338 Score = 23.9 bits (50), Expect(2) = 2e-10 Identities = 10/35 (28%), Positives = 20/35 (57%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 L+H ++++L G C ++ + LV ++ G L L Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL 232
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 48.9 bits (115), Expect(2) = 3e-10 Identities = 29/85 (34%), Positives = 43/85 (50%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L Y+H + I+HRD+K NI++ K++DFG S P + G+ Sbjct: 217 ADALDYMH---ERNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSK---RKTLCGTV 270 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE R + EK DV++ GV+ Sbjct: 271 DYLSPELIRSREYNEKVDVWALGVL 295 Score = 34.3 bits (77), Expect(2) = 3e-10 Identities = 14/37 (37%), Positives = 23/37 (62%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 S LRH +L L GY ++ + L+ +Y+ +G L +HL Sbjct: 162 SSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHL 198
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 63.2 bits (152), Expect = 3e-10 Identities = 38/98 (38%), Positives = 55/98 (56%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L + + I I A+ L H K IIHRDVK NIL+ E+ V KV+DFG++K+ S Sbjct: 105 LPYEVAISIGIKVAKALECAH---KSGIIHRDVKPQNILVTEEGVVKVTDFGIAKSMDSS 161 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 H ++V+ GS Y PE + ++D+YS G+V Sbjct: 162 TIAHTNSVM-GSAHYFSPEQAKGTYTDYRTDLYSLGIV 198
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 55.5 bits (132), Expect(2) = 3e-10 Identities = 32/92 (34%), Positives = 48/92 (52%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L I I A G+ YL + H +H+D+ NIL+ E+ K+SD GLS+ S D+ V Sbjct: 593 LHIAIQIAAGMEYL---SSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQ 649 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + ++ PE + SD++SFGVV Sbjct: 650 SKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVV 681 Score = 27.3 bits (59), Expect(2) = 3e-10 Identities = 10/37 (27%), Positives = 23/37 (62%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++L H ++V L+G ++ + ++++Y+ G L E L Sbjct: 528 AELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFL 564
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 51.2 bits (121), Expect(2) = 3e-10 Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 2/108 (1%) Frame = +1 Query: 118 YTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFG 297 Y R L +++C A G+ YL + IHRD+ NIL+ E + KV+DFG Sbjct: 323 YLRGDGRSLKLPDLVDMCSQVASGMSYLE---QQNYIHRDLAARNILVGEHKICKVADFG 379 Query: 298 LSKTGPSMDHTHVSTVVKGSF--GYLDPEYFRXQXLTEKSDVYSFGVV 435 L++ +D + F + PE T KSDV+SFG+V Sbjct: 380 LARV---IDEEIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVWSFGIV 424 Score = 31.6 bits (70), Expect(2) = 3e-10 Identities = 13/36 (36%), Positives = 22/36 (61%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +LRH L+ L C ++ + +V + M HG+L E+L Sbjct: 289 QLRHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYL 324
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 56.6 bits (135), Expect(2) = 4e-10 Identities = 32/93 (34%), Positives = 52/93 (55%), Gaps = 8/93 (8%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEK--------WVAKVSDFGLSKTGPSMDHTHV 336 ARG+ YLH A I+HRD+K++NILL EK K++DFGL++ H Sbjct: 245 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW----HRTT 300 Query: 337 STVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G++ ++ PE + ++ SD++S+GV+ Sbjct: 301 KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVL 333 Score = 25.8 bits (55), Expect(2) = 4e-10 Identities = 11/35 (31%), Positives = 19/35 (54%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 LRH +++ L G C ++ + LV ++ G L L Sbjct: 178 LRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL 212
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 43.9 bits (102), Expect(2) = 4e-10 Identities = 36/143 (25%), Positives = 51/143 (35%), Gaps = 39/143 (27%) Frame = +1 Query: 124 RPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS 303 R L Q L I A G+ YL A +HRD+ T N L+ + K+ DFG+S Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMS 701 Query: 304 KTGPSMDHTHVSTVVKGSFG---------------------------------------Y 366 + S D+ KG F + Sbjct: 702 RDVYSTDYYREGPYQKGPFSVSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRW 761 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 + PE + T +SDV+SFGV+ Sbjct: 762 MPPESIMYRKFTTESDVWSFGVI 784 Score = 38.5 bits (88), Expect(2) = 4e-10 Identities = 14/37 (37%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 + L+H H+V G C + + +I+V++YM HG L + L Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 62.4 bits (150), Expect = 5e-10 Identities = 34/92 (36%), Positives = 53/92 (57%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L++ AA GL +H + ++HRD+K N+L+ + K++DFG++K S+ T Sbjct: 126 LDVMEQAAHGLSVIH---RMGLVHRDIKPGNMLITANGILKITDFGIAKAAASVPLTRTG 182 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 VV G+ Y+ PE + +T SDVYS GVV Sbjct: 183 MVV-GTAQYVSPEQAQGHQVTPASDVYSLGVV 213
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 62.4 bits (150), Expect = 5e-10 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 12/110 (10%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ EK V K+SDFG Sbjct: 161 PLSCREQLSLGKCLKYSLDIVNGLLFLHS---QSILHLDLKPANILISEKDVCKISDFGC 217 Query: 301 S------KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S + PS+ H + G++ + PE + + T K+D+YSFG+ Sbjct: 218 SQKLQDLRCRPSLHH------IGGTYTHQAPELLKGEIATPKADIYSFGI 261
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 62.0 bits (149), Expect = 6e-10 Identities = 35/101 (34%), Positives = 53/101 (52%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 + P+ +Q +EI A + L++ H ++ IIHRDVK NI++ KV DFG+++ Sbjct: 107 DGPMPPQQAIEIVADACQALNFSH---QNGIIHRDVKPANIMISATNAVKVMDFGIARAI 163 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + V G+ YL PE R + +SDVYS G V Sbjct: 164 ADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCV 204
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 62.0 bits (149), Expect = 6e-10 Identities = 38/110 (34%), Positives = 54/110 (49%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+S Y R + L +C+ G+ YL +IHRD+ N L+ E V KV Sbjct: 442 CLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC---VIHRDLAARNCLVGENQVIKV 498 Query: 286 SDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +T ST K + PE F + KSDV+SFGV+ Sbjct: 499 SDFGMTRFVLDDQYTS-STGTKFPVKWASPEVFSFSRYSSKSDVWSFGVL 547 Score = 37.0 bits (84), Expect = 0.021 Identities = 23/70 (32%), Positives = 32/70 (45%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXCTA*LEAAFGDLHRCCSWA 191 KL H LV L G C E+ + LV+++M HG L ++L +TQ E G C Sbjct: 412 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYL-RTQRGLFAAETLLGMCLDVCEGM 470 Query: 192 SLPSYRCKAH 221 + C H Sbjct: 471 AYLEEACVIH 480
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 48.9 bits (115), Expect(2) = 7e-10 Identities = 31/85 (36%), Positives = 44/85 (51%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 + L YLH IIHRD+K NILL K+SDFG S PS + + + G+ Sbjct: 207 SEALLYLHG---KNIIHRDIKPENILLHFNDTIKISDFGWSVHAPS----NRRSTLCGTM 259 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE + + + DV+S G++ Sbjct: 260 DYLPPEIVQSRPYDKNVDVWSLGIL 284 Score = 32.7 bits (73), Expect(2) = 7e-10 Identities = 12/33 (36%), Positives = 22/33 (66%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 S LRH +++ L G+ +K+ + L+ +Y+ HG L Sbjct: 152 SNLRHTNVLRLFGHFHDKDRVYLILEYVVHGEL 184
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 61.6 bits (148), Expect = 8e-10 Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 1/111 (0%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ Y R L Q LE+C G+ +L + H IHRD+ N L+D KV Sbjct: 496 CLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES---HQFIHRDLAARNCLVDRDLCVKV 552 Query: 286 SDFGLSKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +D +VS+V K + PE F + KSDV++FG++ Sbjct: 553 SDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGIL 601
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 61.6 bits (148), Expect = 8e-10 Identities = 32/92 (34%), Positives = 54/92 (58%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 L++ AA GL +H + ++HRD+K N+L+ + K++DFG++K ++ T Sbjct: 126 LDVMEQAAHGLSVIH---RMDMVHRDIKPGNMLITANGIVKITDFGIAKAAAAVPLTRTG 182 Query: 340 TVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 VV G+ Y+ PE + + +T SD+YS GVV Sbjct: 183 MVV-GTAQYVSPEQAQGKEVTAASDIYSLGVV 213
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 48.9 bits (115), Expect(2) = 9e-10 Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 5/113 (4%) Frame = +1 Query: 112 STYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSD 291 S+ P L+ + +RG+ YL A+ ++HRD+ NIL+ E K+SD Sbjct: 837 SSLDHPDERVLTMGDLISFAWQISRGMQYL---AEMKLVHRDLAARNILVAEGRKMKISD 893 Query: 292 FGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 FGLS+ D + VK S G + ++ + L T +SDV+SFGV+ Sbjct: 894 FGLSR-----DVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVL 941 Score = 32.3 bits (72), Expect(2) = 9e-10 Identities = 11/36 (30%), Positives = 22/36 (61%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 ++ H H++ L G C + ++L+ +Y +G+LR L Sbjct: 782 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL 817
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 51.2 bits (121), Expect(2) = 1e-09 Identities = 31/85 (36%), Positives = 43/85 (50%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L Y H+ +IHRD+K N+LL K++DFG S PS T + G+ Sbjct: 248 AEALLYCHS---KKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----TTLCGTL 300 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE + EK D++S GV+ Sbjct: 301 DYLPPEMIEGRMHDEKVDLWSLGVL 325 Score = 30.0 bits (66), Expect(2) = 1e-09 Identities = 14/39 (35%), Positives = 21/39 (53%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S LRH +++ L GY + + + L+ DY G L L K Sbjct: 193 SHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQK 231
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 52.0 bits (123), Expect(2) = 1e-09 Identities = 31/85 (36%), Positives = 43/85 (50%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L Y H+ +IHRD+K N+LL K++DFG S PS T + G+ Sbjct: 232 ANALSYCHS---KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----TTMCGTL 284 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE + EK D++S GV+ Sbjct: 285 DYLPPEMIEGRMHDEKVDLWSLGVL 309 Score = 29.3 bits (64), Expect(2) = 1e-09 Identities = 13/39 (33%), Positives = 21/39 (53%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S LRH +++ L GY + + L+ +Y GT+ L K Sbjct: 177 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 215
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 61.2 bits (147), Expect = 1e-09 Identities = 34/93 (36%), Positives = 51/93 (54%), Gaps = 8/93 (8%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILL--------DEKWVAKVSDFGLSKTGPSMDHTHV 336 ARG+HYLH A +IHRD+K+ NILL E K++DFGL++ H Sbjct: 223 ARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREW----HKTT 278 Query: 337 STVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G++ ++ PE + ++ SDV+SFGV+ Sbjct: 279 QMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVL 311
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 61.2 bits (147), Expect = 1e-09 Identities = 38/102 (37%), Positives = 54/102 (52%), Gaps = 1/102 (0%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 N LS R ++ +G L Y H + IIHRD+K NI++ E+ V KV DFG+++ Sbjct: 115 NGALSQRDCEQVMLGVLNALDYSH---RMGIIHRDIKPGNIMISEQGVVKVMDFGIARAL 171 Query: 313 PSMDHTHV-STVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 T S V G+ YL PE R + + +SD+YS G V Sbjct: 172 DDSAATMTQSQGVVGTAQYLSPEQARGETVDMRSDLYSAGCV 213
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 61.2 bits (147), Expect = 1e-09 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 ++I A+G+ YLH +IIHRD+K+ NI L E K+ DFGL+ +H Sbjct: 594 IDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 650 Query: 340 TVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVY+FG+V Sbjct: 651 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV 685
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 61.2 bits (147), Expect = 1e-09 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 ++I A+G+ YLH +IIHRD+K+ NI L E K+ DFGL+ +H Sbjct: 116 IDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 172 Query: 340 TVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVY+FG+V Sbjct: 173 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV 207
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 61.2 bits (147), Expect = 1e-09 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 ++I A+G+ YLH +IIHRD+K+ NI L E K+ DFGL+ +H Sbjct: 594 IDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 650 Query: 340 TVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVY+FG+V Sbjct: 651 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV 685
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 61.2 bits (147), Expect = 1e-09 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 ++I A+G+ YLH +IIHRD+K+ NI L E K+ DFGL+ +H Sbjct: 164 IDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 220 Query: 340 TVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVY+FG+V Sbjct: 221 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV 255
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 61.2 bits (147), Expect = 1e-09 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 ++I A+G+ YLH +IIHRD+K+ NI L E K+ DFGL+ +H Sbjct: 554 IDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 610 Query: 340 TVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVY+FG+V Sbjct: 611 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV 645
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 61.2 bits (147), Expect = 1e-09 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 ++I A+G+ YLH +IIHRD+K+ NI L E K+ DFGL+ +H Sbjct: 180 IDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 236 Query: 340 TVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVY+FG+V Sbjct: 237 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV 271
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 57.4 bits (137), Expect(2) = 1e-09 Identities = 32/82 (39%), Positives = 49/82 (59%) Frame = +1 Query: 190 LHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYL 369 L+YLH+ + I+HRD+K N+LLD+ AK+ DFGL++ THV T +KG+ Y+ Sbjct: 113 LYYLHS---NRILHRDLKPQNVLLDKNMHAKLCDFGLARN--MTLGTHVLTSIKGTPLYM 167 Query: 370 DPEYFRXQXLTEKSDVYSFGVV 435 PE Q +D++S G + Sbjct: 168 APELLAEQPYDHHADMWSLGCI 189 Score = 23.5 bits (49), Expect(2) = 1e-09 Identities = 7/27 (25%), Positives = 18/27 (66%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDY 89 ++L+H H++ +I E K ++ +V ++ Sbjct: 56 ARLKHPHVIEMIESFESKTDLFVVTEF 82
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 51.6 bits (122), Expect(2) = 1e-09 Identities = 31/85 (36%), Positives = 43/85 (50%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L Y H+ +IHRD+K N+LL K++DFG S PS T + G+ Sbjct: 241 ANALSYCHS---KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR----TTLCGTL 293 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE + EK D++S GV+ Sbjct: 294 DYLPPEMIEGRMHDEKVDLWSLGVL 318 Score = 29.3 bits (64), Expect(2) = 1e-09 Identities = 13/39 (33%), Positives = 21/39 (53%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S LRH +++ L GY + + L+ +Y GT+ L K Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 224
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 47.8 bits (112), Expect(2) = 2e-09 Identities = 35/113 (30%), Positives = 56/113 (49%), Gaps = 5/113 (4%) Frame = +1 Query: 112 STYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSD 291 S+ P L+ + ++G+ YL A+ ++HRD+ NIL+ E K+SD Sbjct: 836 SSLDHPDERALTMGDLISFAWQISQGMQYL---AEMKLVHRDLAARNILVAEGRKMKISD 892 Query: 292 FGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXL-----TEKSDVYSFGVV 435 FGLS+ D + VK S G + ++ + L T +SDV+SFGV+ Sbjct: 893 FGLSR-----DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVL 940 Score = 32.7 bits (73), Expect(2) = 2e-09 Identities = 11/40 (27%), Positives = 25/40 (62%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 ++ H H++ L G C + ++L+ +Y +G+LR L +++ Sbjct: 781 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 60.5 bits (145), Expect = 2e-09 Identities = 34/104 (32%), Positives = 57/104 (54%), Gaps = 6/104 (5%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG Sbjct: 163 PLSCREQLSLGKCLKYSLDVVNGLLFLHS---QSILHLDLKPANILISEQDVCKISDFGC 219 Query: 301 SKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S+ + + G++ + PE + + T K+D+YSFG+ Sbjct: 220 SQKLQDLRCRQSPHHIGGTYTHQAPEILKGEIATPKADIYSFGI 263
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.5 bits (145), Expect = 2e-09 Identities = 33/101 (32%), Positives = 58/101 (57%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 N + + + ++ A+ L++ H K+ I+HRD+K NI++ + + KV+DFG++K Sbjct: 102 NGKIEFNKIIDYATQIAKALNFAH---KNGIVHRDIKPHNIMVTDDDIIKVTDFGIAKAS 158 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 T + VV GS YL PE + + ++D+YSFG+V Sbjct: 159 NESTITTTNKVV-GSAHYLSPEQAQGIPVDCRTDIYSFGIV 198
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 60.5 bits (145), Expect = 2e-09 Identities = 34/98 (34%), Positives = 55/98 (56%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS L + + +RG+ YLH+ +IHRD+K+ N+LL+++ KV+DFG S Sbjct: 184 LSIETVLRLALDISRGMEYLHSQG---VIHRDLKSNNLLLNDEMRVKVADFGTSCLETQC 240 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + G++ ++ PE + + T K DVYSFG+V Sbjct: 241 REAKGN---MGTYRWMAPEMIKEKPYTRKVDVYSFGIV 275
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 52.0 bits (123), Expect(2) = 2e-09 Identities = 35/102 (34%), Positives = 52/102 (50%), Gaps = 6/102 (5%) Frame = +1 Query: 148 WRQRLEICIGAARGLHYL-HTGAKHTIIH-RDVKTTNILLDEKWVAKVSDFGLSK----T 309 W + E+ G A G+ YL G H + RD+ N+LLD + K++DFGLS+ Sbjct: 818 WEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSRGVRSE 877 Query: 310 GPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G S++ + + K + PE + T SDV+SFGVV Sbjct: 878 GSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVV 919 Score = 28.1 bits (61), Expect(2) = 2e-09 Identities = 12/36 (33%), Positives = 22/36 (61%) Frame = +3 Query: 21 HRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKT 128 H +++ LIG +++V +YMA+G+L + L T Sbjct: 774 HPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNT 809
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 60.1 bits (144), Expect = 2e-09 Identities = 34/83 (40%), Positives = 50/83 (60%), Gaps = 1/83 (1%) Frame = +1 Query: 190 LHYLHTGAKHTIIHRDVKTTNILLDE-KWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 LH++HT H I+HRD+KT NILLD+ + V K+ DFG+SK S + V G+ Y Sbjct: 116 LHHVHT---HLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAY---TVVGTPCY 169 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 + PE + +KSD+++ G V Sbjct: 170 ISPELCEGKPYNQKSDIWALGCV 192
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 60.1 bits (144), Expect = 2e-09 Identities = 34/83 (40%), Positives = 50/83 (60%), Gaps = 1/83 (1%) Frame = +1 Query: 190 LHYLHTGAKHTIIHRDVKTTNILLDE-KWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 LH++HT H I+HRD+KT NILLD+ + V K+ DFG+SK S + V G+ Y Sbjct: 116 LHHVHT---HLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAY---TVVGTPCY 169 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 + PE + +KSD+++ G V Sbjct: 170 ISPELCEGKPYNQKSDIWALGCV 192
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 59.7 bits (143), Expect = 3e-09 Identities = 37/111 (33%), Positives = 57/111 (51%), Gaps = 1/111 (0%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ Y + L Q LE+C G+ +L + H IHRD+ N L+D KV Sbjct: 472 CLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLES---HQFIHRDLAARNCLVDSDLSVKV 528 Query: 286 SDFGLSKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +D +VS+V K + PE F + KSDV++FG++ Sbjct: 529 SDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGIL 577
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 59.7 bits (143), Expect = 3e-09 Identities = 36/110 (32%), Positives = 55/110 (50%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ + R S L +C G+ YL +++ IHRD+ N L++E V KV Sbjct: 448 CLLNFLRQRQGHFSRDMLLSMCQDVCEGMEYLE---RNSFIHRDLAARNCLVNEAGVVKV 504 Query: 286 SDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +T S+ K + PE F + KSDV+SFGV+ Sbjct: 505 SDFGMARYVLDDQYTS-SSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVL 553
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 46.2 bits (108), Expect(2) = 3e-09 Identities = 29/97 (29%), Positives = 47/97 (48%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 +S+ L + A G+ YL T +HRD+ T N L+ E + K++DFG+S+ + Sbjct: 738 ISYPMLLHVAAQIASGMRYLAT---LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 794 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 D+ V ++ E T SDV++FGV Sbjct: 795 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 831 Score = 33.1 bits (74), Expect(2) = 3e-09 Identities = 16/53 (30%), Positives = 29/53 (54%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXCTA*LEAAFGD 167 S+L+ +++ L+G C + + + ++ DYM +G L + L Q E A GD Sbjct: 677 SRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGD 729
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 46.2 bits (108), Expect(2) = 3e-09 Identities = 29/97 (29%), Positives = 47/97 (48%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 +S+ L + A G+ YL T +HRD+ T N L+ E + K++DFG+S+ + Sbjct: 734 ISYPMLLHVAAQIASGMRYLAT---LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 790 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 D+ V ++ E T SDV++FGV Sbjct: 791 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 827 Score = 33.1 bits (74), Expect(2) = 3e-09 Identities = 16/53 (30%), Positives = 29/53 (54%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXCTA*LEAAFGD 167 S+L+ +++ L+G C + + + ++ DYM +G L + L Q E A GD Sbjct: 673 SRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGD 725
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 59.3 bits (142), Expect = 4e-09 Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 1/84 (1%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS-KTGPSMDHTHVSTVVKGSFG 363 G+ YLH K IIHRD+K NIL+D K K++DFG+S K P + ++GS Sbjct: 587 GVAYLH---KKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVF 643 Query: 364 YLDPEYFRXQXLTEKSDVYSFGVV 435 ++ PE + T K+D++S G V Sbjct: 644 WMSPEVVKQTATTAKADIWSTGCV 667
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 59.3 bits (142), Expect = 4e-09 Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 1/100 (1%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKT-GP 315 P++ ++ +E+ A + L++ H ++ IIHRDVK NI++ KV DFG+++ Sbjct: 109 PMTPKRAIEVIADACQALNFSH---QNGIIHRDVKPANIMISATNAVKVMDFGIARAIAD 165 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S + + V G+ YL PE R + +SDVYS G V Sbjct: 166 SGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCV 205
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 59.3 bits (142), Expect = 4e-09 Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 1/100 (1%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKT-GP 315 P++ ++ +E+ A + L++ H ++ IIHRDVK NI++ KV DFG+++ Sbjct: 109 PMTPKRAIEVIADACQALNFSH---QNGIIHRDVKPANIMISATNAVKVMDFGIARAIAD 165 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 S + + V G+ YL PE R + +SDVYS G V Sbjct: 166 SGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCV 205
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 59.3 bits (142), Expect = 4e-09 Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 7/105 (6%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG Sbjct: 194 PLSCRKQLSLGKCLKYSLDVVNGLLFLHS---QSILHLDLKPANILISEQDVCKISDFGC 250 Query: 301 SKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S+ + S + G++ + PE + + T K+D+YSFG+ Sbjct: 251 SQKLQDLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGI 295
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 45.1 bits (105), Expect(2) = 4e-09 Identities = 29/85 (34%), Positives = 44/85 (51%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A G+ YL A+H IHRD+ N L+ E + K++DFGL++ +T K Sbjct: 417 ASGMSYLE--ARH-FIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYT-AHAGAKFPI 472 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 + PE + KSDV++FGV+ Sbjct: 473 KWTAPEGLAFNTFSSKSDVWAFGVL 497 Score = 33.9 bits (76), Expect(2) = 4e-09 Identities = 13/38 (34%), Positives = 24/38 (63%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKT 128 L H++LV L+G C + ++ ++M +G L E+L +T Sbjct: 362 LHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRT 399
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 56.2 bits (134), Expect(2) = 5e-09 Identities = 37/100 (37%), Positives = 52/100 (52%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A +S Q L+ + A G+ YL + ++HRD+ NIL+ E VAKVSDFGL+K Sbjct: 281 ALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLAKAEL 337 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 VK + PE + + KSDV+SFGV+ Sbjct: 338 RKGLDSSRLPVK----WTAPEALKNGRFSSKSDVWSFGVL 373 Score = 22.7 bits (47), Expect(2) = 5e-09 Identities = 11/33 (33%), Positives = 22/33 (66%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 +KL+HR+LV L+G + + +V ++++ G L Sbjct: 240 TKLQHRNLVRLLGVILH-HGLYIVMEHVSKGNL 271
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 48.9 bits (115), Expect(2) = 5e-09 Identities = 30/85 (35%), Positives = 42/85 (49%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L Y H+ +IHRD+K N+LL K++DFG S PS T + G+ Sbjct: 248 AEALLYCHS---KKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----TTLCGTL 300 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE + E D++S GV+ Sbjct: 301 DYLPPEMIEGRMHDETVDLWSLGVL 325 Score = 30.0 bits (66), Expect(2) = 5e-09 Identities = 14/39 (35%), Positives = 21/39 (53%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S LRH +++ L GY + + + L+ DY G L L K Sbjct: 193 SHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQK 231
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 49.7 bits (117), Expect(2) = 5e-09 Identities = 30/85 (35%), Positives = 42/85 (49%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L Y H+ +IHRD+K N+LL K++DFG S PS T + G+ Sbjct: 234 ANALSYCHS---KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----TTLCGTL 286 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y PE + EK D++S GV+ Sbjct: 287 DYQPPEMIEGRMHDEKVDLWSLGVL 311 Score = 29.3 bits (64), Expect(2) = 5e-09 Identities = 13/39 (33%), Positives = 21/39 (53%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYK 125 S LRH +++ L GY + + L+ +Y GT+ L K Sbjct: 179 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 217
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 3/104 (2%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILL---DEKWVAKVSDFGLS 303 N L W R+++ A GL YLH I HRD+ + N L+ + + A V+DFGL+ Sbjct: 145 NLHLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLA 201 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + P + V GS ++ PE R + EK+DV+S+G++ Sbjct: 202 EKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGII 245
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 7/105 (6%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG Sbjct: 194 PLSCREQLSLGKCLKYSLDVVNGLLFLHS---QSILHLDLKPANILISEQDVCKISDFGC 250 Query: 301 SKTGPSMDHTHVST-VVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S+ + S + G++ + PE + + T K+D+YSFG+ Sbjct: 251 SQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGI 295
>GUC2C_HUMAN (P25092) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR) Length = 1073 Score = 58.9 bits (141), Expect = 5e-09 Identities = 31/114 (27%), Positives = 56/114 (49%) Frame = +1 Query: 94 LMEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKW 273 L E T + P + W ++ + A+G+ YLH+ T +H +K+TN ++D + Sbjct: 569 LREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSK--TEVHGRLKSTNCVVDSRM 626 Query: 274 VAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 V K++DFG + P + PE+ R +++K DVYS+G++ Sbjct: 627 VVKITDFGCNSILPPKKDL-----------WTAPEHLRQANISQKGDVYSYGII 669
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 7/105 (6%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG Sbjct: 194 PLSCREQLSLGKCLKYSLDVVNGLLFLHS---QSILHLDLKPANILISEQDVCKISDFGC 250 Query: 301 SKTGPSMDHTHVST-VVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S+ + S + G++ + PE + + T K+D+YSFG+ Sbjct: 251 SQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGI 295
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 47.8 bits (112), Expect(2) = 6e-09 Identities = 34/85 (40%), Positives = 44/85 (51%), Gaps = 3/85 (3%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGS--- 357 G+ YLH A+H IHRD+ N+LLD + K+ DFGL+K P H + G Sbjct: 1010 GMAYLH--AQH-YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE-GHEYYRVREDGDSPV 1065 Query: 358 FGYLDPEYFRXQXLTEKSDVYSFGV 432 F Y PE + SDV+SFGV Sbjct: 1066 FWYA-PECLKEYKFYYASDVWSFGV 1089 Score = 30.8 bits (68), Expect(2) = 6e-09 Identities = 14/37 (37%), Positives = 24/37 (64%), Gaps = 2/37 (5%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNE--MILVYDYMAHGTLREHL 119 L H H++ G CE++ E + LV +Y+ G+LR++L Sbjct: 954 LYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL 990 Score = 29.6 bits (65), Expect = 3.4 Identities = 13/33 (39%), Positives = 19/33 (57%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 S++ H HL + G C E I+V +Y+ HG L Sbjct: 663 SQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL 695
>PKN2_HUMAN (Q16513) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 984 Score = 51.6 bits (122), Expect(2) = 6e-09 Identities = 30/83 (36%), Positives = 45/83 (54%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH +H I++RD+K N+LLD + K++DFGL K G M + ++ G+ + Sbjct: 769 GLQYLH---EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEG--MGYGDRTSTFCGTPEF 823 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 L PE T D + GV+ Sbjct: 824 LAPEVLTETSYTRAVDWWGLGVL 846 Score = 26.9 bits (58), Expect(2) = 6e-09 Identities = 12/38 (31%), Positives = 20/38 (52%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 + +RH LV+L + K + V +Y A G L H++ Sbjct: 713 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH 750
>PKN2_MOUSE (Q8BWW9) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 983 Score = 51.6 bits (122), Expect(2) = 6e-09 Identities = 30/83 (36%), Positives = 45/83 (54%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH +H I++RD+K N+LLD + K++DFGL K G M + ++ G+ + Sbjct: 768 GLQYLH---EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEG--MGYGDRTSTFCGTPEF 822 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 L PE T D + GV+ Sbjct: 823 LAPEVLTETSYTRAVDWWGLGVL 845 Score = 26.9 bits (58), Expect(2) = 6e-09 Identities = 12/38 (31%), Positives = 20/38 (52%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 + +RH LV+L + K + V +Y A G L H++ Sbjct: 712 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH 749
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 47.4 bits (111), Expect(2) = 6e-09 Identities = 38/114 (33%), Positives = 56/114 (49%), Gaps = 13/114 (11%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTG 312 + PLS + R I + G+ YLH +IH+D+K NIL+D + K++D GL+ Sbjct: 109 STPLSVKGR--IILEIIEGMCYLHGKG---VIHKDLKPENILVDNDFHIKIADLGLASFK 163 Query: 313 -----PSMDHTHVSTV------VKGSFGYLDPEYFRXQXL--TEKSDVYSFGVV 435 + +H + V G+ Y+ PE+ TEKSDVYSF VV Sbjct: 164 MWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVV 217 Score = 31.2 bits (69), Expect(2) = 6e-09 Identities = 16/44 (36%), Positives = 25/44 (56%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXCT 140 ++LRH +V L+G E+ + LV +YM G L H+ K + T Sbjct: 68 NRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLM-HVLKAEMST 110
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 55.8 bits (133), Expect(2) = 6e-09 Identities = 36/101 (35%), Positives = 54/101 (53%), Gaps = 1/101 (0%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKT-G 312 A +S Q L+ + A G+ YL + ++HRD+ NIL+ E VAKVSDFGL+K Sbjct: 320 ALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLAKAER 376 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +D + + + PE + + KSDV+SFGV+ Sbjct: 377 KGLDSSRLPV------KWTAPEALKNGRFSSKSDVWSFGVL 411 Score = 22.7 bits (47), Expect(2) = 6e-09 Identities = 11/33 (33%), Positives = 22/33 (66%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 +KL+HR+LV L+G + + +V ++++ G L Sbjct: 279 TKLQHRNLVRLLGVILH-HGLYIVMEHVSKGNL 310
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 47.8 bits (112), Expect(2) = 6e-09 Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 2/96 (2%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKT--GPSMDH 327 Q++++ A G+ YL + IHRD+ N+L+ E + KV+DFGL++ + D Sbjct: 330 QQVDMAAQVASGMAYLES---RNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDI 386 Query: 328 THVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +K + PE R + KSDV+SFG++ Sbjct: 387 YESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGIL 422 Score = 30.8 bits (68), Expect(2) = 6e-09 Identities = 12/35 (34%), Positives = 22/35 (62%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 LRH L+ L C ++ + ++ + M HG+L+E+L Sbjct: 284 LRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYL 318
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 58.5 bits (140), Expect = 7e-09 Identities = 32/87 (36%), Positives = 48/87 (55%) Frame = +1 Query: 175 GAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKG 354 G A G++YL + H +HRD+ NIL+++ KVSDFGL++ D T+ + K Sbjct: 732 GIASGMNYL---SNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKI 788 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + PE + T SDV+SFG+V Sbjct: 789 PIRWTAPEAIAHRIFTTASDVWSFGIV 815
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 58.5 bits (140), Expect = 7e-09 Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 3/97 (3%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q ++I A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + Sbjct: 435 QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQ 491 Query: 334 VSTVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 + GS ++ PE R Q + +SDVYS+G+V Sbjct: 492 QVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIV 528
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 58.5 bits (140), Expect = 7e-09 Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 7/105 (6%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG Sbjct: 174 PLSCRKQLSLGKCLKYSLDVVNGLLFLHS---QSILHLDLKPANILISEQDVCKISDFGC 230 Query: 301 SKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S+ + S + G++ + PE + + T K+D+YSFG+ Sbjct: 231 SQKLQVLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGI 275
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 58.5 bits (140), Expect = 7e-09 Identities = 36/110 (32%), Positives = 54/110 (49%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ + R S L +C G+ YL +++ IHRD+ N L+ E V KV Sbjct: 449 CLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLE---RNSFIHRDLAARNCLVSEAGVVKV 505 Query: 286 SDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +T S+ K + PE F + KSDV+SFGV+ Sbjct: 506 SDFGMARYFLDDQYTS-SSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVL 554
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 47.4 bits (111), Expect(2) = 7e-09 Identities = 37/101 (36%), Positives = 49/101 (48%), Gaps = 13/101 (12%) Frame = +1 Query: 169 CIGAAR----------GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 C+G A+ G+ YLH A+H IHRD+ N+LLD + K+ DFGL+K P Sbjct: 987 CVGLAQLLLFAQQICEGMAYLH--AQH-YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE 1043 Query: 319 MDHTHVSTVVKGS---FGYLDPEYFRXQXLTEKSDVYSFGV 432 H + G F Y PE + SDV+SFGV Sbjct: 1044 -GHEYYRVREDGDSPVFWYA-PECLKECKFYYASDVWSFGV 1082 Score = 30.8 bits (68), Expect(2) = 7e-09 Identities = 15/37 (40%), Positives = 24/37 (64%), Gaps = 2/37 (5%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNE--MILVYDYMAHGTLREHL 119 L H H+V G CE++ E + LV +Y+ G+LR++L Sbjct: 947 LYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL 983 Score = 30.4 bits (67), Expect = 2.0 Identities = 13/33 (39%), Positives = 20/33 (60%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTL 107 S++ H HL L G C +E I+V +++ HG L Sbjct: 656 SQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPL 688
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 58.2 bits (139), Expect = 9e-09 Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 7/105 (6%) Frame = +1 Query: 139 PLSWRQRLEI------CIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGL 300 PLS R++L + + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG Sbjct: 210 PLSCREQLSLGKCLKYSLDVVNGLLFLHS---QSILHLDLKPANILISEQDVCKISDFGC 266 Query: 301 SKTGPSMDHTHVST-VVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 S+ + S + G++ + PE + + T K+D+YSFG+ Sbjct: 267 SQKLQVLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGI 311
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 58.2 bits (139), Expect = 9e-09 Identities = 34/87 (39%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGVV Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVV 1272
>GUC2C_PIG (P55204) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) Length = 1073 Score = 58.2 bits (139), Expect = 9e-09 Identities = 33/115 (28%), Positives = 57/115 (49%), Gaps = 1/115 (0%) Frame = +1 Query: 94 LMEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKW 273 L E T + P + W ++ + A+G+ YLH+ T +H +K+TN ++D + Sbjct: 569 LREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSK--TEVHGRLKSTNCVVDSRM 626 Query: 274 VAKVSDFGL-SKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 V K++DFG S P D + PE+ R +++K DVYS+G++ Sbjct: 627 VVKITDFGCNSILAPKKDL------------WTAPEHLRRASVSQKGDVYSYGII 669
>LET23_CAEEL (P24348) Receptor tyrosine-protein kinase let-23 precursor (EC| 2.7.10.1) (Lethal protein 23) Length = 1367 Score = 50.4 bits (119), Expect(2) = 9e-09 Identities = 33/100 (33%), Positives = 52/100 (52%), Gaps = 3/100 (3%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L R+++ C A G+ YL K ++HRD+ T N+L+ + +++DFGLSK + Sbjct: 1026 LGAREQVLYCYQIASGMQYLE---KQRVVHRDLATRNVLVKKFNHVEITDFGLSKI---L 1079 Query: 322 DHTHVSTVVKG---SFGYLDPEYFRXQXLTEKSDVYSFGV 432 H S +K + +L E F T SDV++FGV Sbjct: 1080 KHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGV 1119 Score = 27.3 bits (59), Expect(2) = 9e-09 Identities = 12/36 (33%), Positives = 21/36 (58%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +LRH +L+ +IG+C + + +V Y G L+ L Sbjct: 984 RLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL 1019
>PKN2_RAT (O08874) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) (Protease-activated kinase 2) (PAK-2) (Fragment) Length = 842 Score = 50.8 bits (120), Expect(2) = 1e-08 Identities = 30/83 (36%), Positives = 45/83 (54%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH +H I++RD+K N+LLD + K++DFGL K G M + ++ G+ + Sbjct: 633 GLQYLH---EHKIVYRDLKLDNLLLDTEASVKIADFGLCKEG--MGYGDRTSTFCGTPEF 687 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 L PE T D + GV+ Sbjct: 688 LAPEVLTETSYTRAVDWWGLGVL 710 Score = 26.9 bits (58), Expect(2) = 1e-08 Identities = 12/38 (31%), Positives = 20/38 (52%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLY 122 + +RH LV+L + K + V +Y A G L H++ Sbjct: 577 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH 614
>GUC2C_CAVPO (P70106) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (Guanylyl cyclase C) Length = 1076 Score = 57.8 bits (138), Expect = 1e-08 Identities = 31/114 (27%), Positives = 54/114 (47%) Frame = +1 Query: 94 LMEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKW 273 L E T + P + W ++ + A+G+ YLH+ +H +K+TN ++D + Sbjct: 572 LREVLNETISYPDGTIMGWEFKISVLYDIAKGMSYLHSSKIE--VHGRLKSTNCVVDSRM 629 Query: 274 VAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 V K++DFG + P + PE+ R ++K DVYSFG++ Sbjct: 630 VVKITDFGYNSILPPKKDL-----------WTAPEHLRQASTSQKGDVYSFGII 672
>RIPK5_CHICK (Q6XUX0) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 57.8 bits (138), Expect = 1e-08 Identities = 34/100 (34%), Positives = 53/100 (53%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L RL+I + G+ YLH+ ++HRD+K N+LLD+K AK++D G K Sbjct: 748 AGLELETRLQIALDVVEGIRYLHSQG---LVHRDIKLKNVLLDKKNRAKITDLGFCKPEA 804 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 805 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 838
>RIPK5_XENLA (Q67E01) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 916 Score = 57.8 bits (138), Expect = 1e-08 Identities = 33/98 (33%), Positives = 52/98 (53%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS RL+I + G+ +LH ++HRD+K N+LLD+K AK++D G K M Sbjct: 738 LSLETRLQIALDVVEGIRFLHNQG---VVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMM 794 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + V T + ++ PE F + DVY+FG++ Sbjct: 795 SGSIVGTPI-----HMAPELFSGK-YDNSVDVYAFGIL 826
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/104 (33%), Positives = 54/104 (51%), Gaps = 3/104 (2%) Frame = +1 Query: 133 NAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILL---DEKWVAKVSDFGLS 303 N L W R+++ A GL YLH I HRD+ + N L+ + + A V+DFGL+ Sbjct: 145 NLYLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLA 201 Query: 304 KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + P V GS ++ PE R + EK+DV+S+G++ Sbjct: 202 EKIPDASIGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGII 245
>RIPK5_XENTR (Q67E00) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 918 Score = 57.4 bits (137), Expect = 2e-08 Identities = 33/98 (33%), Positives = 52/98 (53%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 LS RL+I + G+ +LH ++HRD+K N+LLD+K AK++D G K M Sbjct: 740 LSLETRLQIALDVVEGIRFLHNQG---LVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMM 796 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + V T + ++ PE F + DVY+FG++ Sbjct: 797 SGSIVGTPI-----HMAPELFSGK-YDNSVDVYAFGIL 828
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 3/97 (3%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q ++I A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + Sbjct: 444 QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 334 VSTVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 GS ++ PE R Q + +SDVYS+G+V Sbjct: 501 QVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIV 537
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 1/111 (0%) Frame = +1 Query: 106 CVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKV 285 C+ Y R L L +C G+ YL ++ IHRD+ N L+ + K+ Sbjct: 350 CLLNYLRENKGKLRKEMLLSVCQDICEGMEYLE---RNGYIHRDLAARNCLVSSTCIVKI 406 Query: 286 SDFGLSKTGPSMDHTHVSTV-VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 SDFG+++ +D +VS+ K + PE F + KSDV+SFGV+ Sbjct: 407 SDFGMTRY--VLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVL 455
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 57.4 bits (137), Expect = 2e-08 Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 5/87 (5%) Frame = +1 Query: 184 RGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVST-----VV 348 +GL YLH+ I+HRD+K NIL+D K K+SDFG+SK ++ T T Sbjct: 508 KGLEYLHSRG---IVHRDIKGANILVDNKGKIKISDFGISKK-LELNSTSTKTGGARPSF 563 Query: 349 KGSFGYLDPEYFRXQXLTEKSDVYSFG 429 +GS ++ PE + TEK+D++S G Sbjct: 564 QGSSFWMAPEVVKQTMHTEKTDIWSLG 590
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 44.7 bits (104), Expect(2) = 2e-08 Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 5/108 (4%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P P + ++ +++ A G+ YL+ +HRD+ N ++ + K+ DFG+++ Sbjct: 1116 PGRPPPTLQEMIQMTAEIADGMAYLNA---KKFVHRDLAARNCMVAHDFTVKIGDFGMTR 1172 Query: 307 TGPSMDHTHVSTVVKGSFG-----YLDPEYFRXQXLTEKSDVYSFGVV 435 D+ KG G ++ PE + T SD++SFGVV Sbjct: 1173 DIYETDYYR-----KGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVV 1215 Score = 32.3 bits (72), Expect(2) = 2e-08 Identities = 13/31 (41%), Positives = 20/31 (64%) Frame = +3 Query: 27 HLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 H+V L+G + M++V + MAHG L+ HL Sbjct: 1075 HVVRLLGVVSKGQPMLVVMELMAHGDLKSHL 1105
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 50.1 bits (118), Expect(2) = 2e-08 Identities = 33/88 (37%), Positives = 44/88 (50%), Gaps = 1/88 (1%) Frame = +1 Query: 175 GAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKG 354 G A L YLH + I+HRD+K NI++ + K+ DFGLS S H G Sbjct: 252 GIASALIYLHA---NNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFC---G 305 Query: 355 SFGYLDPEYFRXQXLT-EKSDVYSFGVV 435 S + PE + T + DV+SFGVV Sbjct: 306 SLYFAAPELLKANPYTGPEVDVWSFGVV 333 Score = 26.9 bits (58), Expect(2) = 2e-08 Identities = 12/44 (27%), Positives = 21/44 (47%), Gaps = 10/44 (22%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMA----------HGTLREH 116 L H H+ L C N ++++Y++ HG++REH Sbjct: 201 LYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREH 244
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 47.4 bits (111), Expect(2) = 2e-08 Identities = 30/99 (30%), Positives = 48/99 (48%) Frame = +1 Query: 139 PLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS 318 PLS + ++ +C A G+ +L G +HRD+ N L+ + KVS LSK + Sbjct: 882 PLSTKHKVSLCTQVALGMEHLSNGR---FVHRDLAARNCLVSAQRQVKVSALSLSKDVYN 938 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ H ++ PE + KSDV+SFGV+ Sbjct: 939 SEYYHFRQAWI-PLRWMPPEAVLEDEFSTKSDVWSFGVL 976 Score = 29.6 bits (65), Expect(2) = 2e-08 Identities = 13/36 (36%), Positives = 21/36 (58%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 KL H ++V L+G C E +V +Y+ G L++ L Sbjct: 833 KLNHVNVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 868
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 52.0 bits (123), Expect(2) = 2e-08 Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 6/102 (5%) Frame = +1 Query: 148 WRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPS--- 318 W QR+ A G+ YLH+ IIHRD+ + N L+ E V++FGLS+ P Sbjct: 409 WNQRVSFARDIAAGMTYLHS---MNIIHRDLNSHNCLVREDGGLVVANFGLSRLIPEETR 465 Query: 319 ---MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D TVV G+ ++ PE + E DV+SFG+V Sbjct: 466 DLRKDRRKRYTVV-GNPYWMAPEMINGRSYDESVDVFSFGIV 506 Score = 25.0 bits (53), Expect(2) = 2e-08 Identities = 10/32 (31%), Positives = 17/32 (53%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLR 110 L H H++ IG + + + +Y+ GTLR Sbjct: 366 LEHPHVLKFIGVLYKDKRLNFITEYIPGGTLR 397
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 50.1 bits (118), Expect(2) = 2e-08 Identities = 35/86 (40%), Positives = 46/86 (53%), Gaps = 1/86 (1%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS-KTGPSMDHTHVSTVVKGS 357 A L YLHT KH IIHRD+K NILL K+SDFG S K+ PS ++ + G+ Sbjct: 256 ALALDYLHT--KH-IIHRDIKPENILLSTDNCIKLSDFGWSVKSLPSSSTKRLT--ICGT 310 Query: 358 FGYLDPEYFRXQXLTEKSDVYSFGVV 435 YL PE D++S G++ Sbjct: 311 LDYLPPEMIESNEHDYTVDIWSLGIL 336 Score = 26.9 bits (58), Expect(2) = 2e-08 Identities = 12/37 (32%), Positives = 18/37 (48%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 S L H + L G+ + + L+ +Y HG L HL Sbjct: 201 SNLIHPKISRLYGFFYDHKNVYLILEYSIHGELYHHL 237
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1187 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1243 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1244 PVKWMALESLQTQKFTTKSDVWSFGVL 1270
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVL 1272
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVL 1272
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVL 1272
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVL 1272
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/85 (41%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A GL +LH+ II+RD+K NILLDE+ K++DFGLSK ++DH + G+ Sbjct: 172 ALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTV 226 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE Q T +D +S+GV+ Sbjct: 227 EYMAPEVVNRQGHTHSADWWSYGVL 251 Score = 35.4 bits (80), Expect = 0.062 Identities = 24/89 (26%), Positives = 47/89 (52%), Gaps = 4/89 (4%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTGPSMDHTHVSTVV 348 ++ + YLH+ ++HRD+K +NIL +DE ++ DFG +K + + ++ Sbjct: 509 SKTVEYLHSQG---VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY 565 Query: 349 KGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +F + PE + Q E D++S G++ Sbjct: 566 TANF--VAPEVLKRQGYDEGCDIWSLGIL 592
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 57.0 bits (136), Expect = 2e-08 Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 3/101 (2%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILL---DEKWVAKVSDFGLSKTG 312 L W R+++ A GL YLH I HRD+ + N L+ + + A V+DFGL++ Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKI 204 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 P V GS ++ PE R + EK+DV+S+G++ Sbjct: 205 PDASIGREKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGII 245
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 3/97 (3%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q ++I A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + Sbjct: 119 QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 175 Query: 334 VSTVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 GS ++ PE R Q + +SDVYS+G+V Sbjct: 176 QVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIV 212
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 57.0 bits (136), Expect = 2e-08 Identities = 34/88 (38%), Positives = 46/88 (52%), Gaps = 3/88 (3%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + GS Sbjct: 533 AQGMDYLHA---KNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSI 589 Query: 361 GYLDPEYFRXQXLTE---KSDVYSFGVV 435 ++ PE R Q L +SDVY+FG+V Sbjct: 590 LWMAPEVIRMQELNPYSFQSDVYAFGIV 617
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/85 (41%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A GL +LH+ II+RD+K NILLDE+ K++DFGLSK ++DH + G+ Sbjct: 172 ALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTV 226 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE Q T +D +S+GV+ Sbjct: 227 EYMAPEVVNRQGHTHSADWWSYGVL 251 Score = 35.8 bits (81), Expect = 0.047 Identities = 25/89 (28%), Positives = 47/89 (52%), Gaps = 4/89 (4%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTGPSMDHTHVSTVV 348 ++ + YLH+ ++HRD+K +NIL +DE ++ DFG +K + + ++ Sbjct: 520 SKTVEYLHSQG---VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY 576 Query: 349 KGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 +F + PE + Q E D++S GV+ Sbjct: 577 TANF--VAPEVLKRQGYDEGCDIWSLGVL 603
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVL 1272
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1189 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1245 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1246 PVKWMALESLQTQKFTTKSDVWSFGVL 1272
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1190 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1246 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1247 PVKWMALESLQTQKFTTKSDVWSFGVL 1273
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1190 AKGMKYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1246 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1247 PVKWMALESLQTQKFTTKSDVWSFGVL 1273
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 3/97 (3%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q ++I A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + Sbjct: 444 QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 334 VSTVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 GS ++ PE R Q + +SDVYS+G+V Sbjct: 501 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV 537
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 3/97 (3%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q ++I A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + Sbjct: 444 QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 334 VSTVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 GS ++ PE R Q + +SDVYS+G+V Sbjct: 501 QVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIV 537
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 3/97 (3%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q ++I A+G+ YLH IIHRD+K+ NI L E K+ DFGL+ + Sbjct: 444 QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 500 Query: 334 VSTVVKGSFGYLDPEYFRXQX---LTEKSDVYSFGVV 435 GS ++ PE R Q + +SDVYS+G+V Sbjct: 501 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV 537
>RIPK5_FUGRU (Q4VSN2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 921 Score = 57.0 bits (136), Expect = 2e-08 Identities = 33/100 (33%), Positives = 55/100 (55%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A LS ++RL+I + G+ +LH ++HRD+K N+LLD++ AK++D G K Sbjct: 740 AGLSLQERLQIALDVVEGIRFLHNQG---LLHRDIKLKNVLLDKQNRAKITDLGFCKPEA 796 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 797 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 830
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 49.7 bits (117), Expect(2) = 2e-08 Identities = 31/88 (35%), Positives = 44/88 (50%), Gaps = 1/88 (1%) Frame = +1 Query: 175 GAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKG 354 G A L YLH + I+HRD+K NI++ K+ DFGLS D+ G Sbjct: 231 GIASALQYLHA---NNIVHRDLKIENIMISSSGEIKIIDFGLSNI---FDYRKQLHTFCG 284 Query: 355 SFGYLDPEYFRXQXLT-EKSDVYSFGVV 435 S + PE + Q T + D++SFG+V Sbjct: 285 SLYFAAPELLKAQPYTGPEVDIWSFGIV 312 Score = 26.9 bits (58), Expect(2) = 2e-08 Identities = 12/44 (27%), Positives = 21/44 (47%), Gaps = 10/44 (22%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMA----------HGTLREH 116 L H H+ L C N ++++Y++ HG+L+EH Sbjct: 180 LYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEH 223
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 45.1 bits (105), Expect(2) = 2e-08 Identities = 29/97 (29%), Positives = 47/97 (48%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 +S+ L + A G+ YL T +HRD+ T N L+ E + K++DFG+S+ + Sbjct: 736 ISYPMLLHVGAQIASGMRYLAT---LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 792 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 D+ V ++ E T SDV++FGV Sbjct: 793 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 829 Score = 31.6 bits (70), Expect(2) = 2e-08 Identities = 12/41 (29%), Positives = 25/41 (60%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 S+L+ +++ L+G C + + + ++ DYM +G L + L Q Sbjct: 675 SRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQ 715
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 56.6 bits (135), Expect = 3e-08 Identities = 40/118 (33%), Positives = 60/118 (50%), Gaps = 5/118 (4%) Frame = +1 Query: 97 MEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWV 276 +E +ST++ L W+ R I + +++LH+ K ++H D+K NILLD Sbjct: 106 LEKVLSTHS------LCWKLRFRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLDSNMH 158 Query: 277 AKVSDFGLSK---TGPSMDHTHVSTVVKGSFGYLDPEYF--RXQXLTEKSDVYSFGVV 435 K+SDFGLSK M + S ++G Y+ PE F + K DVYSF +V Sbjct: 159 VKISDFGLSKWMEQSTRMQYIERS-ALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIV 215 Score = 30.4 bits (67), Expect = 2.0 Identities = 14/42 (33%), Positives = 26/42 (61%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQXC 137 K++ +H+VS+ G C K + +V ++MA+G+L + L C Sbjct: 77 KIKFQHIVSIYGVC--KQPLGIVMEFMANGSLEKVLSTHSLC 116
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 56.6 bits (135), Expect = 3e-08 Identities = 33/85 (38%), Positives = 48/85 (56%), Gaps = 2/85 (2%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH+ IIHRD+K N+L+D V K+SDFG+SK ++ + ++GS + Sbjct: 942 GLSYLHSKG---IIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFW 998 Query: 367 LDPEYFR--XQXLTEKSDVYSFGVV 435 + PE Q + K DV+S G V Sbjct: 999 MAPEVIHNDHQGYSAKVDVWSLGCV 1023
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 56.6 bits (135), Expect = 3e-08 Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 8/96 (8%) Frame = +1 Query: 172 IGAARGLHYLHTGAKHTIIHRDVKTTNILLDE--------KWVAKVSDFGLSKTGPSMDH 327 I ARG++YLH A +IIHRD+K++N+L+ E + K++DFGL++ M + Sbjct: 243 IQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR---EMYN 299 Query: 328 THVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 T + G++ ++ PE ++ SDV+S+GV+ Sbjct: 300 TQRMSAA-GTYAWMPPEVISVSTYSKFSDVWSYGVL 334
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 56.6 bits (135), Expect = 3e-08 Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 1/75 (1%) Frame = +1 Query: 214 KHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVST-VVKGSFGYLDPEYFRX 390 K +++HRD+K NI LDE K+ DFGLSK +D+T V T G+ Y+ PE R Sbjct: 144 KQSVLHRDIKPANIFLDENNSVKLGDFGLSKL---LDNTRVFTQSYVGTPYYMSPEIIRS 200 Query: 391 QXLTEKSDVYSFGVV 435 + KSDV++ G V Sbjct: 201 SPYSAKSDVWALGCV 215
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 45.1 bits (105), Expect(2) = 3e-08 Identities = 29/97 (29%), Positives = 47/97 (48%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 +S+ L + A G+ YL T +HRD+ T N L+ E + K++DFG+S+ + Sbjct: 735 ISYPMLLHVGAQIASGMRYLAT---LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 791 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 D+ V ++ E T SDV++FGV Sbjct: 792 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 828 Score = 31.2 bits (69), Expect(2) = 3e-08 Identities = 11/37 (29%), Positives = 24/37 (64%) Frame = +3 Query: 9 SKLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 S+L+ +++ L+G C + + + ++ DYM +G L + L Sbjct: 674 SRLKDLNIIRLLGVCVQDDPLCMITDYMENGDLNQFL 710
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 56.2 bits (134), Expect = 3e-08 Identities = 32/94 (34%), Positives = 51/94 (54%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTH 333 Q + + +G A G++ L + H +HRD+ NIL+++ KVSDFGL++ D T+ Sbjct: 726 QLVAMLLGIASGMNCL---SGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTY 782 Query: 334 VSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + K + PE + T SDV+SFG+V Sbjct: 783 ETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIV 816
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 56.2 bits (134), Expect = 3e-08 Identities = 33/98 (33%), Positives = 52/98 (53%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L+ +Q IC +GL +LH K IIHRD+K+ N+LLD K++DFG Sbjct: 775 LNEKQIATICFETLKGLQHLH---KKHIIHRDIKSDNVLLDAYGNVKITDFGF--CAKLT 829 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D + + G+ ++ PE + + EK DV+S G++ Sbjct: 830 DQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIM 867
>RIPK5_RAT (Q6XUX2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 56.2 bits (134), Expect = 3e-08 Identities = 33/100 (33%), Positives = 54/100 (54%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A LS RL+I + G+ +LH+ ++HRD+K N+LLD++ AK++D G K Sbjct: 745 AGLSLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFCKPEA 801 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 802 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 835
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 56.2 bits (134), Expect = 3e-08 Identities = 35/85 (41%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L +LH+ II+RD+K NILLDE+ K++DFGLSK S+DH + G+ Sbjct: 178 ALALDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--ESIDHEKKAYSFCGTV 232 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE + T+ +D +SFGV+ Sbjct: 233 EYMAPEVVNRRGHTQSADWWSFGVL 257 Score = 33.9 bits (76), Expect = 0.18 Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 4/101 (3%) Frame = +1 Query: 145 SWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTG 312 S R+ + + + YLH ++HRD+K +NIL +DE ++ DFG +K Sbjct: 512 SEREASAVLFTITKTVEYLHAQG---VVHRDLKPSNILYVDESGNPESIRICDFGFAKQL 568 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + + ++ +F + PE + Q D++S GV+ Sbjct: 569 RAENGLLMTPCYTANF--VAPEVLKRQGYDAACDIWSLGVL 607
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 56.2 bits (134), Expect = 3e-08 Identities = 35/85 (41%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L +LH+ II+RD+K NILLDE+ K++DFGLSK S+DH + G+ Sbjct: 178 ALALDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--ESIDHEKKAYSFCGTV 232 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE + T+ +D +SFGV+ Sbjct: 233 EYMAPEVVNRRGHTQSADWWSFGVL 257 Score = 33.9 bits (76), Expect = 0.18 Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 4/101 (3%) Frame = +1 Query: 145 SWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTG 312 S R+ + + + YLH ++HRD+K +NIL +DE ++ DFG +K Sbjct: 512 SEREASAVLFTITKTVEYLHAQG---VVHRDLKPSNILYVDESGNPESIRICDFGFAKQL 568 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + + ++ +F + PE + Q D++S GV+ Sbjct: 569 RAENGLLMTPCYTANF--VAPEVLKRQGYDAACDIWSLGVL 607
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 56.2 bits (134), Expect = 3e-08 Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 1/91 (1%) Frame = +1 Query: 160 LEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVS 339 LE+ IG + L Y H I+HRD+K N++L KV DFG+++ T Sbjct: 116 LEMTIGILQALEYSHRAG---IVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQ 172 Query: 340 T-VVKGSFGYLDPEYFRXQXLTEKSDVYSFG 429 T V G+ YL PE + + + +SD+YS G Sbjct: 173 TAAVIGTAQYLSPEQAKGEQVDARSDLYSTG 203
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 45.1 bits (105), Expect(2) = 3e-08 Identities = 27/74 (36%), Positives = 37/74 (50%) Frame = +1 Query: 214 KHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQ 393 K IHRD+ N L+ E V KV+DFGLS+ +T K + PE Sbjct: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT-AHAGAKFPIKWTAPESLAYN 460 Query: 394 XLTEKSDVYSFGVV 435 + KSDV++FGV+ Sbjct: 461 TFSIKSDVWAFGVL 474 Score = 30.8 bits (68), Expect(2) = 3e-08 Identities = 12/36 (33%), Positives = 23/36 (63%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +++H +LV L+G C + +V +YM +G L ++L Sbjct: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 373
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 55.8 bits (133), Expect = 4e-08 Identities = 34/85 (40%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A L +LH+ II+RD+K NILLDE+ K++DFGLSK ++DH + G+ Sbjct: 169 ALALDHLHSLG---IIYRDLKPENILLDEEGHIKITDFGLSK--EAIDHDKRAYSFCGTI 223 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE + T+ +D +SFGV+ Sbjct: 224 EYMAPEVVNRRGHTQSADWWSFGVL 248 Score = 34.3 bits (77), Expect = 0.14 Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 7/104 (6%) Frame = +1 Query: 145 SWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVA----KVSDFGLSK-- 306 S R+ ++ + + YLH+ ++HRD+K +NIL ++ + +V DFG +K Sbjct: 505 SEREASDVLCTITKTMDYLHSQG---VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQL 561 Query: 307 -TGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 G + T T ++ PE + Q D++S G++ Sbjct: 562 RAGNGLLMTPCYTA-----NFVAPEVLKRQGYDAACDIWSLGIL 600
>RIPK5_BRARE (Q4VSN1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 885 Score = 55.8 bits (133), Expect = 4e-08 Identities = 33/100 (33%), Positives = 55/100 (55%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A LS ++RL I + G+ +LH+ ++HRD+K N+LLD++ AK++D G K Sbjct: 709 AGLSLKERLLIALDVVEGIRFLHSQG---LLHRDIKLKNVLLDKQNRAKITDLGFCKPEA 765 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 766 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 799
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 55.8 bits (133), Expect = 4e-08 Identities = 35/95 (36%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +1 Query: 154 QRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKT-GPSMDHT 330 Q L+ + A G+ YL + ++HRD+ NIL+ E VAKVSDFGL+K +D + Sbjct: 328 QLLQFSLHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS 384 Query: 331 HVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + + PE + T KSDV+SFGV+ Sbjct: 385 RLPV------KWTAPEALKHGKFTSKSDVWSFGVL 413
>MOS_HUMAN (P00540) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 55.8 bits (133), Expect = 4e-08 Identities = 33/98 (33%), Positives = 55/98 (56%), Gaps = 1/98 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLS-KTGPS 318 LS + L+ + GL +LH+ +I+H D+K NIL+ E+ V K+SDFG S K Sbjct: 173 LSLGKCLKYSLDVVNGLLFLHS---QSIVHLDLKPANILISEQDVCKISDFGCSEKLEDL 229 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 + S + G++ + PE + + +T K+D+YSF + Sbjct: 230 LCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAI 267
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 42.7 bits (99), Expect(2) = 4e-08 Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 1/86 (1%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTV-VKGS 357 A G+ YL + IHRD+ N L+ + + KV+DFGL++ D T+ + K Sbjct: 477 ASGMSYLES---RNYIHRDLAARNCLVGDNKLVKVADFGLARL--MRDDTYTAHAGAKFP 531 Query: 358 FGYLDPEYFRXQXLTEKSDVYSFGVV 435 + PE + KSDV++FGV+ Sbjct: 532 IKWTAPEGLAYNKFSTKSDVWAFGVL 557 Score = 32.7 bits (73), Expect(2) = 4e-08 Identities = 12/36 (33%), Positives = 23/36 (63%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +++H +LV LIG C + ++ ++M+HG L + L Sbjct: 421 EMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFL 456
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 49.7 bits (117), Expect(2) = 5e-08 Identities = 29/83 (34%), Positives = 43/83 (51%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH + I+HRD+K N ++E KV DFGL+ ++H + G+ Y Sbjct: 192 GLKYLH---EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRR--RTICGTPNY 246 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 L PE Q +SD+++ G V Sbjct: 247 LSPEVLNKQGHGCESDIWALGCV 269 Score = 25.8 bits (55), Expect(2) = 5e-08 Identities = 10/39 (25%), Positives = 22/39 (56%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 L H+H+V Y E+K + ++ +Y + ++ H+ K + Sbjct: 137 LHHKHVVQFYHYFEDKENIYILLEYCSRRSM-AHILKAR 174
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 49.7 bits (117), Expect(2) = 5e-08 Identities = 29/83 (34%), Positives = 43/83 (51%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH + I+HRD+K N ++E KV DFGL+ ++H + G+ Y Sbjct: 189 GLKYLH---EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRR--RTICGTPNY 243 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 L PE Q +SD+++ G V Sbjct: 244 LSPEVLNKQGHGCESDIWALGCV 266 Score = 25.8 bits (55), Expect(2) = 5e-08 Identities = 10/39 (25%), Positives = 22/39 (56%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 L H+H+V Y E+K + ++ +Y + ++ H+ K + Sbjct: 134 LHHKHVVQFYHYFEDKENIYILLEYCSRRSM-AHILKAR 171
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 49.7 bits (117), Expect(2) = 5e-08 Identities = 29/83 (34%), Positives = 43/83 (51%) Frame = +1 Query: 187 GLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGY 366 GL YLH + I+HRD+K N ++E KV DFGL+ ++H + G+ Y Sbjct: 189 GLKYLH---EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRR--RTICGTPNY 243 Query: 367 LDPEYFRXQXLTEKSDVYSFGVV 435 L PE Q +SD+++ G V Sbjct: 244 LSPEVLNKQGHGCESDIWALGCV 266 Score = 25.8 bits (55), Expect(2) = 5e-08 Identities = 10/39 (25%), Positives = 22/39 (56%) Frame = +3 Query: 15 LRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHLYKTQ 131 L H+H+V Y E+K + ++ +Y + ++ H+ K + Sbjct: 134 LHHKHVVQFYHYFEDKENIYILLEYCSRRSM-AHILKAR 171
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 45.1 bits (105), Expect(2) = 5e-08 Identities = 28/75 (37%), Positives = 39/75 (52%), Gaps = 1/75 (1%) Frame = +1 Query: 214 KHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHT-HVSTVVKGSFGYLDPEYFRX 390 K IHRD+ N L+ E + KV+DFGLS+ +T H T K + PE Sbjct: 305 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGT--KFPIKWTAPESLAY 362 Query: 391 QXLTEKSDVYSFGVV 435 + KSDV++FGV+ Sbjct: 363 NKFSIKSDVWAFGVL 377 Score = 30.4 bits (67), Expect(2) = 5e-08 Identities = 10/36 (27%), Positives = 23/36 (63%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 +++H +LV L+G C + ++ ++M +G L ++L Sbjct: 241 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL 276
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 55.5 bits (132), Expect = 6e-08 Identities = 34/85 (40%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A GL +LH+ II+RD+K NILLDE+ K++DFGLSK ++DH + G+ Sbjct: 172 ALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTV 226 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE Q + +D +S+GV+ Sbjct: 227 EYMAPEVVNRQGHSHSADWWSYGVL 251 Score = 32.7 bits (73), Expect = 0.40 Identities = 25/101 (24%), Positives = 49/101 (48%), Gaps = 4/101 (3%) Frame = +1 Query: 145 SWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTG 312 S R+ + + + LH+ ++HRD+K +NIL +DE ++ DFG +K Sbjct: 506 SEREASSVLFTVCKTVENLHSQG---VVHRDLKPSNILYVDESGDPESIRICDFGFAKQL 562 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + + ++ +F + PE + Q E D++S G++ Sbjct: 563 RADNGLLMTPCYTANF--VAPEVLKRQGYDEGCDIWSLGIL 601
>RIPK5_BOVIN (Q4TVR5) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 928 Score = 55.5 bits (132), Expect = 6e-08 Identities = 33/100 (33%), Positives = 54/100 (54%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L+ RL+I + G+ +LH+ ++HRDVK N+LLD++ AK++D G K Sbjct: 746 AGLALETRLQIALDVVEGIRFLHSQG---LVHRDVKLKNVLLDKQNRAKITDLGFCKPEA 802 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 803 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 836
>KPC1_CAEEL (P34722) Protein kinase C-like 1 (EC 2.7.11.13) (PKC)| (Tetradecanoyl phorbol acetate resistant protein 1) Length = 704 Score = 55.5 bits (132), Expect = 6e-08 Identities = 32/82 (39%), Positives = 49/82 (59%) Frame = +1 Query: 190 LHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYL 369 L +LHT + II+RD+K N+LLD K++DFG++KT + ++ ST G+ Y+ Sbjct: 487 LQFLHT---NNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFC-GTPDYI 542 Query: 370 DPEYFRXQXLTEKSDVYSFGVV 435 PE + Q E D +SFGV+ Sbjct: 543 SPEIIKGQLYNEAVDFWSFGVL 564
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 55.5 bits (132), Expect = 6e-08 Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 1/99 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKW-VAKVSDFGLSKTGPS 318 +SW ++ A GL YLH +IHRDVK N+LL K K+ DF G Sbjct: 115 MSWARQ------CAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDF-----GTV 163 Query: 319 MDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D + + T +GS ++ PE F TEK D++S+ +V Sbjct: 164 ADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIV 202
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 55.5 bits (132), Expect = 6e-08 Identities = 34/85 (40%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A GL +LH+ II+RD+K NILLDE+ K++DFGLSK ++DH + G+ Sbjct: 172 ALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTV 226 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE Q + +D +S+GV+ Sbjct: 227 EYMAPEVVNRQGHSHSADWWSYGVL 251 Score = 35.0 bits (79), Expect = 0.081 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 4/86 (4%) Frame = +1 Query: 190 LHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTGPSMDHTHVSTVVKGS 357 + YLH+ ++HRD+K +NIL +DE ++ DFG +K + + ++ + Sbjct: 523 VEYLHSQG---VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTAN 579 Query: 358 FGYLDPEYFRXQXLTEKSDVYSFGVV 435 F + PE + Q E D++S G++ Sbjct: 580 F--VAPEVLKRQGYDEGCDIWSLGIL 603
>MP2K7_HUMAN (O14733) Dual specificity mitogen-activated protein kinase kinase 7| (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Length = 419 Score = 55.5 bits (132), Expect = 6e-08 Identities = 39/118 (33%), Positives = 59/118 (50%), Gaps = 5/118 (4%) Frame = +1 Query: 94 LMEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKW 273 LM C + P+ R ++ + + L+YL KH +IHRDVK +NILLDE+ Sbjct: 198 LMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE--KHGVIHRDVKPSNILLDERG 255 Query: 274 VAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTE-----KSDVYSFGV 432 K+ DFG+S G +D + T G Y+ PE T+ ++DV+S G+ Sbjct: 256 QIKLCDFGIS--GRLVD-SKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGI 310
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 55.5 bits (132), Expect = 6e-08 Identities = 34/85 (40%), Positives = 51/85 (60%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVSTVVKGSF 360 A GL +LH+ II+RD+K NILLDE+ K++DFGLSK ++DH + G+ Sbjct: 190 ALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTV 244 Query: 361 GYLDPEYFRXQXLTEKSDVYSFGVV 435 Y+ PE Q + +D +S+GV+ Sbjct: 245 EYMAPEVVNRQGHSHSADWWSYGVL 269 Score = 35.4 bits (80), Expect = 0.062 Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 4/101 (3%) Frame = +1 Query: 145 SWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNIL-LDEKW---VAKVSDFGLSKTG 312 S R+ + + + YLH+ ++HRD+K +NIL +DE ++ DFG +K Sbjct: 525 SEREASSVLHTICKTVEYLHSQG---VVHRDLKPSNILYVDESGNPESIRICDFGFAKQL 581 Query: 313 PSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 + + ++ +F + PE + Q E D++S GV+ Sbjct: 582 RAENGLLMTPCYTANF--VAPEVLKRQGYDEGCDIWSLGVL 620
>GUC2C_RAT (P23897) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) Length = 1072 Score = 55.5 bits (132), Expect = 6e-08 Identities = 30/114 (26%), Positives = 54/114 (47%) Frame = +1 Query: 94 LMEPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKW 273 L E T + P + W ++ + A+G+ YLH+ +H +K+TN ++D + Sbjct: 568 LREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIE--VHGRLKSTNCVVDSRM 625 Query: 274 VAKVSDFGLSKTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 V K++DFG + P + PE+ R +++K DVYSF ++ Sbjct: 626 VVKITDFGCNSILPPKKDL-----------WTAPEHLRQATISQKGDVYSFSII 668
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 55.5 bits (132), Expect = 6e-08 Identities = 32/87 (36%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL +HRD+ N +LDEK+ KV+DFGL++ ++ H T K Sbjct: 1190 AKGMKYL---VSKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1246 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1247 PVKWMALESLQTQKFTTKSDVWSFGVL 1273
>MOS_CERAE (P10650) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 55.5 bits (132), Expect = 6e-08 Identities = 36/112 (32%), Positives = 59/112 (52%), Gaps = 1/112 (0%) Frame = +1 Query: 100 EPCVSTYTRPXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVA 279 EP ST PL+ + L+ + GL +LH+ +I+H D+K NIL+ E+ V Sbjct: 164 EPHCST-----GGPLTLGKCLKYSLDVVNGLLFLHS---QSIVHLDLKPANILISEQDVC 215 Query: 280 KVSDFGLS-KTGPSMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 K+SDFG S K + + G++ + PE + + +T K+D+YSF + Sbjct: 216 KISDFGCSEKLEDLLCFQTPLYPLGGTYTHRAPELLKGEGVTPKADIYSFAI 267
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 42.4 bits (98), Expect(2) = 6e-08 Identities = 29/98 (29%), Positives = 48/98 (48%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L + + I A G+ YL + +IHRD+ N+L+ E VAK+ DFGL++ + Sbjct: 376 LHFEDLIYIATQVASGMEYLES---KQLIHRDLAARNVLIGENNVAKICDFGLARV-IAD 431 Query: 322 DHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 D + + PE + KSDV+S+G++ Sbjct: 432 DEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGIL 469 Score = 32.7 bits (73), Expect(2) = 6e-08 Identities = 13/36 (36%), Positives = 22/36 (61%) Frame = +3 Query: 12 KLRHRHLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 K RH LV+L C ++ + +V +YM+ G+L + L Sbjct: 333 KFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFL 368
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 44.7 bits (104), Expect(2) = 8e-08 Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 5/108 (4%) Frame = +1 Query: 127 PXNAPLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSK 306 P P + ++ +++ A G+ YL+ +HRD+ N ++ + K+ DFG+++ Sbjct: 1127 PGRPPPTLQEMIQMTAEIADGMAYLNA---KKFVHRDLAARNCMVAHDFTVKIGDFGMTR 1183 Query: 307 TGPSMDHTHVSTVVKGSFG-----YLDPEYFRXQXLTEKSDVYSFGVV 435 D+ KG G ++ PE + T SD++SFGVV Sbjct: 1184 DIYETDYYR-----KGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVV 1226 Score = 30.0 bits (66), Expect(2) = 8e-08 Identities = 12/31 (38%), Positives = 19/31 (61%) Frame = +3 Query: 27 HLVSLIGYCEEKNEMILVYDYMAHGTLREHL 119 H+V L+G + ++V + MAHG L+ HL Sbjct: 1086 HVVRLLGVVSKGQPTLVVMELMAHGDLKSHL 1116
>RIPK5_CANFA (Q4VSN4) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 931 Score = 55.1 bits (131), Expect = 8e-08 Identities = 32/100 (32%), Positives = 54/100 (54%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L+ RL+I + G+ +LH+ ++HRD+K N+LLD++ AK++D G K Sbjct: 749 AGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFCKPEA 805 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 806 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 839
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 55.1 bits (131), Expect = 8e-08 Identities = 34/90 (37%), Positives = 52/90 (57%) Frame = +1 Query: 163 EICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVST 342 +I RGL YLH + +IHRD+K NILL+E K+ DFG+S G +++ ++T Sbjct: 328 KIAEAVLRGLSYLH---EKKVIHRDIKPQNILLNENGQVKLCDFGVS--GEAVN--SLAT 380 Query: 343 VVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 G+ Y+ PE + Q + SDV+S G+ Sbjct: 381 TFTGTSFYMAPERIQGQPYSVTSDVWSLGL 410
>RIPK5_MOUSE (Q6XUX1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 55.1 bits (131), Expect = 8e-08 Identities = 32/100 (32%), Positives = 54/100 (54%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L+ RL+I + G+ +LH+ ++HRD+K N+LLD++ AK++D G K Sbjct: 745 AGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFCKPEA 801 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 802 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 835
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 55.1 bits (131), Expect = 8e-08 Identities = 36/98 (36%), Positives = 57/98 (58%), Gaps = 1/98 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L + +L I + A+G+ YLH+ IIHRD+ + NILL E A V+DFG S+ S+ Sbjct: 556 LDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 614 Query: 322 DHTHVSTVVKGSFGYLDPEYF-RXQXLTEKSDVYSFGV 432 D ++ T G+ ++ PE F + T K+DV+S+ + Sbjct: 615 DEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYAL 651
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 55.1 bits (131), Expect = 8e-08 Identities = 36/98 (36%), Positives = 57/98 (58%), Gaps = 1/98 (1%) Frame = +1 Query: 142 LSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSM 321 L + +L I + A+G+ YLH+ IIHRD+ + NILL E A V+DFG S+ S+ Sbjct: 557 LDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 615 Query: 322 DHTHVSTVVKGSFGYLDPEYF-RXQXLTEKSDVYSFGV 432 D ++ T G+ ++ PE F + T K+DV+S+ + Sbjct: 616 DEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYSL 652
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 55.1 bits (131), Expect = 8e-08 Identities = 34/90 (37%), Positives = 52/90 (57%) Frame = +1 Query: 163 EICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDHTHVST 342 ++ I RGL YL KH I+HRDVK +NIL++ + K+ DFG+S G +D S Sbjct: 170 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLIDSMANSF 225 Query: 343 VVKGSFGYLDPEYFRXQXLTEKSDVYSFGV 432 V G+ Y+ PE + + +SD++S G+ Sbjct: 226 V--GTRSYMSPERLQGTHYSVQSDIWSMGL 253
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 55.1 bits (131), Expect = 8e-08 Identities = 33/90 (36%), Positives = 51/90 (56%), Gaps = 1/90 (1%) Frame = +1 Query: 169 CIGAARGLHYLHTGAKHTIIHRDVKTTNILL-DEKWVAKVSDFGLSKTGPSMDHTHVSTV 345 C+ ++G+ YLH+ +IHRD+K N+LL V K+ DFG + TH+ T Sbjct: 134 CLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA----CDIQTHM-TN 188 Query: 346 VKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 KGS ++ PE F +EK DV+S+G++ Sbjct: 189 NKGSAAWMAPEVFEGSNYSEKCDVFSWGII 218
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 55.1 bits (131), Expect = 8e-08 Identities = 32/87 (36%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +1 Query: 181 ARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSMDH--THVSTVVKG 354 A+G+ YL A +HRD+ N +LDE + KV+DFGL++ ++ H T K Sbjct: 1190 AKGMKYL---ASKKFVHRDLAARNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKL 1246 Query: 355 SFGYLDPEYFRXQXLTEKSDVYSFGVV 435 ++ E + Q T KSDV+SFGV+ Sbjct: 1247 PVKWMALESLQTQKFTTKSDVWSFGVL 1273
>RIPK5_HUMAN (Q6XUX3) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) Length = 929 Score = 55.1 bits (131), Expect = 8e-08 Identities = 32/100 (32%), Positives = 54/100 (54%) Frame = +1 Query: 136 APLSWRQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGP 315 A L+ RL+I + G+ +LH+ ++HRD+K N+LLD++ AK++D G K Sbjct: 747 AGLTLETRLQIALDVVEGIRFLHSQG---LVHRDIKLKNVLLDKQNRAKITDLGFCKPEA 803 Query: 316 SMDHTHVSTVVKGSFGYLDPEYFRXQXLTEKSDVYSFGVV 435 M + V T + ++ PE F + DVY+FG++ Sbjct: 804 MMSGSIVGTPI-----HMAPELFTGK-YDNSVDVYAFGIL 837 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 63,985,771 Number of Sequences: 219361 Number of extensions: 1315184 Number of successful extensions: 5753 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 4683 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5170 length of database: 80,573,946 effective HSP length: 101 effective length of database: 58,418,485 effective search space used: 2570413340 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
