Clone Name	bags6e14
Clone Library Name	barley_pub

---

No.	Definition	Score (bits)	E Value
1	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	112	5e-25
2	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	107	2e-23
3	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	105	5e-23
4	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	105	6e-23
5	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	103	2e-22
6	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	102	3e-22
7	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	101	7e-22
8	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	101	7e-22
9	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	100	1e-21
10	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	100	1e-21
11	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	99	3e-21
12	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	93	2e-19
13	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	91	9e-19
14	RCC2_MOUSE (Q8BK67) Protein RCC2	91	2e-18
15	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	90	3e-18
16	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	88	8e-18
17	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	88	1e-17
18	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	86	4e-17
19	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	86	5e-17
20	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	83	2e-16
21	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	82	7e-16
22	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	81	9e-16
23	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	78	1e-14
24	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	78	1e-14
25	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	77	2e-14
26	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	75	5e-14
27	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	75	9e-14
28	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	72	6e-13
29	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	72	6e-13
30	RCC1_CANAL (P52499) Protein RCC1	71	1e-12
31	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	67	2e-11
32	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	67	2e-11
33	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	65	9e-11
34	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	64	1e-10
35	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	64	2e-10
36	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	63	3e-10
37	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	63	3e-10
38	RCC1_XENLA (P25183) Regulator of chromosome condensation	61	1e-09
39	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	58	9e-09
40	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	58	9e-09
41	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	58	1e-08
42	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	57	1e-08
43	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	56	4e-08
44	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	55	7e-08
45	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	52	6e-07
46	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	51	1e-06
47	FBX24_HUMAN (O75426) F-box only protein 24	44	2e-04
48	FBX24_MOUSE (Q9D417) F-box only protein 24	44	2e-04
49	TMPS9_RAT (P69526) Transmembrane protease, serine 9 (EC 3.4.21.-...	37	0.016
50	TMPS9_MOUSE (P69525) Transmembrane protease, serine 9 (EC 3.4.21...	34	0.17
51	YB9W_YEAST (P38352) F-box protein YBR280C	33	0.29
52	BAZ2A_MOUSE (Q91YE5) Bromodomain adjacent to zinc finger domain ...	33	0.38
53	COA1_BOVIN (Q9TTS3) Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-a...	32	0.50
54	HCN1_RAT (Q9JKB0) Potassium/sodium hyperpolarization-activated c...	31	1.1
55	HCN1_MOUSE (O88704) Potassium/sodium hyperpolarization-activated...	31	1.1
56	HCN1_RABIT (Q9MZS1) Potassium/sodium hyperpolarization-activated...	31	1.1
57	HCN1_HUMAN (O60741) Potassium/sodium hyperpolarization-activated...	31	1.1
58	VGLD_PRVRI (P07645) Protein gp50	31	1.5
59	COAC_CHICK (P11029) Acetyl-CoA carboxylase (EC 6.4.1.2) (ACC) [I...	30	2.5
60	POF9_SCHPO (O74381) F-box protein pof9	30	2.5
61	COA1_SHEEP (Q28559) Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-a...	30	3.2
62	TMPS9_HUMAN (Q7Z410) Transmembrane protease, serine 9 (EC 3.4.21...	29	4.2
63	HOXH_RALEU (P22320) NAD-reducing hydrogenase hoxS beta subunit (...	29	4.2
64	PLDP1_ARATH (Q9LRZ5) Phospholipase D p1 (EC 3.1.4.4) (AtPLDp1) (...	29	4.2
65	SRBS1_HUMAN (Q9BX66) Sorbin and SH3 domain-containing protein 1 ...	29	5.5
66	RERE_HUMAN (Q9P2R6) Arginine-glutamic acid dipeptide repeats pro...	29	5.5
67	MDC1_HUMAN (Q14676) Mediator of DNA damage checkpoint protein 1 ...	28	7.2
68	DDX20_MOUSE (Q9JJY4) Probable ATP-dependent RNA helicase DDX20 (...	28	7.2
69	MDC1_PANTR (Q7YR40) Mediator of DNA damage checkpoint protein 1	28	7.2
70	COAC_SCHPO (P78820) Acetyl-CoA carboxylase (EC 6.4.1.2) (ACC) (C...	28	7.2
71	PDC6I_XENLA (Q9W6C5) Programmed cell death 6-interacting protein...	28	7.2
72	COA1_RAT (P11497) Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alp...	28	7.2
73	MTF1_HUMAN (Q14872) Metal-regulatory transcription factor 1 (Tra...	28	7.2
74	TAM_ECOLI (P76145) Trans-aconitate 2-methyltransferase (EC 2.1.1...	28	9.4
75	PALB_NEUCR (Q7RZP7) Calpain-like protease palB/rim-13 (EC 3.4.22...	28	9.4
76	YVAP_VACCC (P20525) Hypothetical 9.9 kDa protein	28	9.4
77	Y2082_MYCTU (Q10690) Hypothetical protein Rv2082	28	9.4
78	HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (P...	28	9.4
79	YJQ0_YEAST (P46999) Uncharacterized protein YJL160C precursor	28	9.4
80	GLNE_CORDI (Q6NG61) Glutamate-ammonia-ligase adenylyltransferase...	28	9.4
81	DEOR_BACSU (P39140) Deoxyribonucleoside regulator	28	9.4
82	CP74A_ARATH (Q96242) Cytochrome P450 74A, chloroplast precursor ...	28	9.4

---

>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  112 bits (279), Expect = 5e-25
 Identities = 53/136 (38%), Positives = 80/136 (58%), Gaps = 1/136 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 204
           I Q++CG+ HCLA+   G+  +WG+N +GQLGLG    S   PQ +++ EGI +  +AAG
Sbjct: 139 ILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG 198

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 384
             H+ A++  G ++GWG    G LGL D  DR  P  V  +   K+V ++CG  HT  ++
Sbjct: 199 GAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLT 258

Query: 385 XXGSLYTYXWSKYGQL 432
             G ++T+     GQL
Sbjct: 259 KSGGVFTFGAGSCGQL 274



 Score = 98.2 bits (243), Expect = 7e-21
 Identities = 51/137 (37%), Positives = 81/137 (59%), Gaps = 2/137 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL-LPQTIQAFEGISVKMIAAG 204
           I  +ACG+SH LA++  G++ SWG   +GQLGL TTEDS+ +P+ IQ     ++  ++ G
Sbjct: 86  IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 145

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLG-DRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 381
             H  A+  DG  + WG   +G LGLG +   +  P++V S+EG  +  VA G  H+  +
Sbjct: 146 NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205

Query: 382 SXXGSLYTYXWSKYGQL 432
           S  G+++ +  +  GQL
Sbjct: 206 SLSGAVFGWGMNNAGQL 222



 Score = 95.5 bits (236), Expect = 5e-20
 Identities = 50/145 (34%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
 Frame = +1

Query: 1   RSRRCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI 180
           R R   G  + Q+A G +H  A++++G V  WG N  GQLGL   +D   P  ++     
Sbjct: 183 RVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ 242

Query: 181 SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
            V  I+ G EHTA +T+ G ++ +G G  G LG    ND   P +V  + G ++  +ACG
Sbjct: 243 KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACG 302

Query: 361 WRHTIT-VSXXGSLYTYXWSKYGQL 432
            +HT+  V   G +Y +     GQL
Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQL 327



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 41/136 (30%), Positives = 70/136 (51%), Gaps = 1/136 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           +K++ACG +H + +   GEV + G N  GQLG     +   P+ I A     +  +A G 
Sbjct: 36  VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADQHIIHVACGE 93

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF-VPEKVSSVEGDKMVLVACGWRHTITVS 384
            H+ A+++ G ++ WG G  G LGL    D   VP  +  +    ++ V+CG  H + ++
Sbjct: 94  SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALA 153

Query: 385 XXGSLYTYXWSKYGQL 432
             G  +T+  + +GQL
Sbjct: 154 ADGQFFTWGKNSHGQL 169



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 36/118 (30%), Positives = 59/118 (50%), Gaps = 2/118 (1%)
 Frame = +1

Query: 85  VLSWGRNQNGQLGLGTTEDSLL--PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 258
           +L WG    GQ G+ T    ++  PQ        SVK +A G  H+  + EDG++Y  G 
Sbjct: 1   MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 259 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
              G LG     ++  PE++ ++    ++ VACG  H++ +S  G L+++     GQL
Sbjct: 61  NTKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQL 116

---

>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score =  107 bits (266), Expect = 2e-23
 Identities = 51/136 (37%), Positives = 79/136 (58%), Gaps = 1/136 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 204
           I Q+ CGD H LA++  GE+ +WG+N +GQLG+G    S   PQ ++   G+ +  I+AG
Sbjct: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG 199

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 384
             H+ A++  G+IY WG    G LGLG    +  P  +  ++  K+  VACG  H+  ++
Sbjct: 200 EAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLT 259

Query: 385 XXGSLYTYXWSKYGQL 432
             G L+T+   K+GQL
Sbjct: 260 QDGLLFTFGAGKHGQL 275



 Score =  102 bits (253), Expect = 5e-22
 Identities = 49/139 (35%), Positives = 84/139 (60%), Gaps = 1/139 (0%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  + Q++ G++H +A++M+G + SWG+N+ GQLGLG TE    P  I+  +   V+ +A
Sbjct: 190 GVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVA 249

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            G  H+A +T+DG ++ +G G++G LG     +   P  V+ + G ++  +ACG  HT+ 
Sbjct: 250 CGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLA 309

Query: 379 -VSXXGSLYTYXWSKYGQL 432
            VS  G ++++   K GQL
Sbjct: 310 YVSDLGKVFSFGSGKDGQL 328



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 25/75 (33%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLA-VTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
           G  + Q+ACG  H LA V+  G+V S+G  ++GQLG G T D L+P  ++      +K+ 
Sbjct: 294 GYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLE 353

Query: 196 AAGAEHTAAVTEDGD 240
           +  +E    +   G+
Sbjct: 354 SHTSEKELIMIAGGN 368



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 30/134 (22%), Positives = 58/134 (43%)
 Frame = +1

Query: 31  KQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 210
           +QL C       +   G  +   +   G  G  T      P+ I+  + + +  +  GAE
Sbjct: 54  RQLCCSPGRLAVLERGGAGVQVHQLLAGSGGART------PKCIKLGKNMKIHSVDQGAE 107

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
           H   ++ DG  +      Y N  +  ++ RF     S ++  K++ + CG  H++ +S  
Sbjct: 108 HMLILSSDGKPF-----EYDNYSM--KHLRFE----SILQEKKIIQITCGDYHSLALSKG 156

Query: 391 GSLYTYXWSKYGQL 432
           G L+ +  + +GQL
Sbjct: 157 GELFAWGQNLHGQL 170

---

>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  105 bits (262), Expect = 5e-23
 Identities = 54/139 (38%), Positives = 84/139 (60%), Gaps = 4/139 (2%)
 Frame = +1

Query: 28   IKQLAC--GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAA 201
            IK++A   G  HCLA++  GEV SWG  ++G+LG G       P+ I++  GI V  +AA
Sbjct: 4039 IKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAA 4098

Query: 202  GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTI 375
            G  H+A VT  GD+Y WG GRYG LG  D  D+  P+ V +++G ++V +ACG     T+
Sbjct: 4099 GGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTL 4158

Query: 376  TVSXXGSLYTYXWSKYGQL 432
             ++   +++++    YG+L
Sbjct: 4159 CLTDDDTVWSWGDGDYGKL 4177



 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 49/141 (34%), Positives = 81/141 (57%), Gaps = 2/141 (1%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            RG  +  +A G +H   VT AG++ +WG+ + G+LG   +ED L P+ ++A +G  V  I
Sbjct: 4089 RGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDI 4148

Query: 196  AAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
            A G+    T  +T+D  ++ WG G YG LG G  +   VP K+ S+ G  +V V CG + 
Sbjct: 4149 ACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQF 4208

Query: 370  TITVSXXGSLYTYXWSKYGQL 432
            ++ ++  G++YT+    Y +L
Sbjct: 4209 SVALTKSGAVYTWGKGDYHRL 4229



 Score = 95.5 bits (236), Expect = 5e-20
 Identities = 46/136 (33%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  +  +ACG ++  A+T  GE+ +WGR   G+LG G++ED  +P  +   +G+ V  +A
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609

Query: 199 AGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            G+    T AVTE+G ++ WG G YG LG G  +    P+ +  ++   +V V CG + +
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669

Query: 373 ITVSXXGSLYTYXWSK 420
           I ++  G +Y+  W K
Sbjct: 670 IALTKDGQVYS--WGK 683



 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 45/131 (34%), Positives = 77/131 (58%), Gaps = 2/131 (1%)
 Frame = +1

Query: 46   GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
            G  H  A+T+ G+V SWG   +G+LG  +  +   P+ I+A +   ++ IA G+ H+AA+
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAL 3114

Query: 226  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWR--HTITVSXXGSL 399
            T  G++Y WG G YG LG GD   +  P+ V  + G +++ VACG R   T+ ++  G +
Sbjct: 3115 TSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLV 3174

Query: 400  YTYXWSKYGQL 432
            +++    +G+L
Sbjct: 3175 FSWGDGDFGKL 3185



 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 51/132 (38%), Positives = 74/132 (56%), Gaps = 6/132 (4%)
 Frame = +1

Query: 55  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAEHTAA 222
           H LA+   GEV SWG    G+LG G T     P+ I AF G      V  IA G+ ++AA
Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 565

Query: 223 VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSXXGS 396
           +T +G++Y WG G YG LG G   D  +P  V+ ++G K++ VACG     T+ V+  G 
Sbjct: 566 ITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQ 625

Query: 397 LYTYXWSKYGQL 432
           ++++    YG+L
Sbjct: 626 VWSWGDGDYGKL 637



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 51/139 (36%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
 Frame = +1

Query: 19   GSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
            G  + Q+ACG  D+  LA+T  G V SWG    G+LG G +E   +PQ I+   G  V  
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3209

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            I  GA+ + A+T+ G ++ WG G Y  LG G       P+ V  + G K+V VA G  H 
Sbjct: 3210 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3269

Query: 373  ITVSXXGSLYTYXWSKYGQ 429
            + V+  G +Y +  + +GQ
Sbjct: 3270 LAVTDSGQVYAWGDNDHGQ 3288



 Score = 88.2 bits (217), Expect = 8e-18
 Identities = 45/135 (33%), Positives = 76/135 (56%), Gaps = 2/135 (1%)
 Frame = +1

Query: 34   QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGA 207
            QL  G+    AVT  G++ + G    G+LG+G TE    P  +++ + + +K +A  +G 
Sbjct: 3989 QLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGG 4048

Query: 208  EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSX 387
            +H  A++ +G++Y WG    G LG G+R+    P  + S+ G ++V VA G  H+  V+ 
Sbjct: 4049 KHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTA 4108

Query: 388  XGSLYTYXWSKYGQL 432
             G LYT+   +YG+L
Sbjct: 4109 AGDLYTWGKGRYGRL 4123



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 41/137 (29%), Positives = 75/137 (54%), Gaps = 2/137 (1%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
            I+ +ACG SH  A+T +GE+ +WG  + G+LG G     L P+ ++   G  V  +A G+
Sbjct: 3101 IRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160

Query: 208  E--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 381
                T A+T++G ++ WG G +G LG G      +P+ +  + G  +  + CG + ++ +
Sbjct: 3161 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLAL 3220

Query: 382  SXXGSLYTYXWSKYGQL 432
            +  G ++T+    Y +L
Sbjct: 3221 TKSGVVWTWGKGDYFRL 3237



 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 44/141 (31%), Positives = 74/141 (52%), Gaps = 2/141 (1%)
 Frame = +1

Query: 16   RGSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
            +G  +  +ACG  D+  L +T    V SWG    G+LG G ++   +P  I +  G+ V 
Sbjct: 4141 QGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV 4200

Query: 190  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
             +  G++ + A+T+ G +Y WG G Y  LG G  +    P +V  ++G K++ +A G  H
Sbjct: 4201 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4260

Query: 370  TITVSXXGSLYTYXWSKYGQL 432
             +  +  G +YT+  +  GQL
Sbjct: 4261 CVCCTEDGEVYTWGDNDEGQL 4281



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 43/122 (35%), Positives = 66/122 (54%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
            G  + ++ CG    +A+T +G V +WG+    +LG G+ +    P+ +Q  +G  V  IA
Sbjct: 4196 GLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIA 4255

Query: 199  AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
             G+ H    TEDG++Y WG    G LG G  N    P  V++++G K+  VACG  HT+ 
Sbjct: 4256 TGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4315

Query: 379  VS 384
             S
Sbjct: 4316 WS 4317



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 42/122 (34%), Positives = 61/122 (50%)
 Frame = +1

Query: 10   RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
            R  G  + Q+ CG    LA+T +G V +WG+    +LG G+      PQ ++   G  + 
Sbjct: 3201 RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260

Query: 190  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
             +A GA H  AVT+ G +Y WG   +G  G G       P  V  +EG K+  VACG  H
Sbjct: 3261 HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSH 3320

Query: 370  TI 375
            ++
Sbjct: 3321 SV 3322



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 46/138 (33%), Positives = 76/138 (55%), Gaps = 3/138 (2%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL-LPQTIQAFEGISVKMIA-- 198
            + Q+A G     AVT+ G+V + G   NG+LGLG +  ++ +P+ I A     VK +A  
Sbjct: 2994 VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVH 3053

Query: 199  AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            +G  H  A+T DG ++ WG G  G LG   R +   P  + +++  ++  +ACG  H+  
Sbjct: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAA 3113

Query: 379  VSXXGSLYTYXWSKYGQL 432
            ++  G LYT+   +YG+L
Sbjct: 3114 LTSSGELYTWGLGEYGRL 3131



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 40/133 (30%), Positives = 72/133 (54%), Gaps = 2/133 (1%)
 Frame = +1

Query: 16  RGSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
           +G  +  +ACG  D+  LAVT  G+V SWG    G+LG G ++    P+ I+  + + V 
Sbjct: 601 KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV 660

Query: 190 MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
            +  G++ + A+T+DG +Y WG G    LG G       P+ +  ++G K++ VA G  H
Sbjct: 661 KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 720

Query: 370 TITVSXXGSLYTY 408
            + ++    ++++
Sbjct: 721 CLALTEDSEVHSW 733



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 28/76 (36%), Positives = 46/76 (60%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           + ++ CG    +A+T  G+V SWG+  N +LG GT E    P+ ++  +G  V  +AAG+
Sbjct: 659 VVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGS 718

Query: 208 EHTAAVTEDGDIYGWG 255
            H  A+TED +++ WG
Sbjct: 719 THCLALTEDSEVHSWG 734



 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 31/71 (43%), Positives = 42/71 (59%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            RG  I  +A G  HCLAVT +G+V +WG N +GQ G GTT  +  P  +Q  EG  +  +
Sbjct: 3255 RGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRV 3314

Query: 196  AAGAEHTAAVT 228
            A G+ H+ A T
Sbjct: 3315 ACGSSHSVAWT 3325



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 2/130 (1%)
 Frame = +1

Query: 49   DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVT 228
            D   L+   +G +  WG N  GQLG        +P   +A   +    +  G +   AVT
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001

Query: 229  EDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--DKMVLVACGWRHTITVSXXGSLY 402
             DG +Y  G+G  G LG+G       P  + S++    K V V  G +H + +S  G +Y
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061

Query: 403  TYXWSKYGQL 432
            ++  ++ G+L
Sbjct: 4062 SWGEAEDGKL 4071



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 28/69 (40%), Positives = 38/69 (55%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            +G  +  +A G  HC+  T  GEV +WG N  GQLG GTT     P+ + A +G  V  +
Sbjct: 4247 QGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRV 4306

Query: 196  AAGAEHTAA 222
            A G+ HT A
Sbjct: 4307 ACGSAHTLA 4315



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 39/141 (27%), Positives = 66/141 (46%), Gaps = 3/141 (2%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
            GS I++ A G     A T+  +V  WG N   QLG        +P   +    ++V  +A
Sbjct: 2941 GSLIRKKAAGLES--AATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA 2998

Query: 199  AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF-VPEKVSSVEG--DKMVLVACGWRH 369
             G++   AVT +G +Y  G    G LGLG  +    +P +++++     K V V  G RH
Sbjct: 2999 GGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRH 3058

Query: 370  TITVSXXGSLYTYXWSKYGQL 432
               ++  G ++++     G+L
Sbjct: 3059 ATALTVDGKVFSWGEGDDGKL 3079



 Score = 35.0 bits (79), Expect = 0.077
 Identities = 15/34 (44%), Positives = 20/34 (58%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQ 117
           +G  +  +A G +HCLA+T   EV SWG N   Q
Sbjct: 707 QGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740

---

>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  105 bits (261), Expect = 6e-23
 Identities = 53/139 (38%), Positives = 84/139 (60%), Gaps = 4/139 (2%)
 Frame = +1

Query: 28   IKQLAC--GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAA 201
            IK++A   G  HCLA++  GEV SWG  ++G+LG G       P+ I++  GI V  +AA
Sbjct: 4041 IKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAA 4100

Query: 202  GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTI 375
            G  H+A VT  GD+Y WG GRYG LG  D  D+  P+ V +++G +++ +ACG     T+
Sbjct: 4101 GGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTL 4160

Query: 376  TVSXXGSLYTYXWSKYGQL 432
             ++   +++++    YG+L
Sbjct: 4161 CLTDDDTVWSWGDGDYGKL 4179



 Score = 96.7 bits (239), Expect = 2e-20
 Identities = 49/141 (34%), Positives = 81/141 (57%), Gaps = 2/141 (1%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            RG  +  +A G +H   VT AG++ +WG+ + G+LG   +ED L P+ ++A +G  V  I
Sbjct: 4091 RGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDI 4150

Query: 196  AAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
            A G+    T  +T+D  ++ WG G YG LG G  +   VP K+ S+ G  +V V CG + 
Sbjct: 4151 ACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQF 4210

Query: 370  TITVSXXGSLYTYXWSKYGQL 432
            ++ ++  G++YT+    Y +L
Sbjct: 4211 SVALTKSGAVYTWGKGDYHRL 4231



 Score = 95.1 bits (235), Expect = 6e-20
 Identities = 45/136 (33%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  +  +ACG ++  A+T  GE+ +WGR   G+LG G++ED  +P  +   +G+ V  +A
Sbjct: 551 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 610

Query: 199 AGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            G+    T AVTE+G ++ WG G YG LG G  +    P+ +  ++   ++ V CG + +
Sbjct: 611 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFS 670

Query: 373 ITVSXXGSLYTYXWSK 420
           I ++  G +Y+  W K
Sbjct: 671 IALTKDGQVYS--WGK 684



 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 51/132 (38%), Positives = 74/132 (56%), Gaps = 6/132 (4%)
 Frame = +1

Query: 55  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAEHTAA 222
           H LA+   GEV SWG    G+LG G T     P+ I AF G      V  IA G+ ++AA
Sbjct: 507 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 566

Query: 223 VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSXXGS 396
           +T +G++Y WG G YG LG G   D  +P  V+ ++G K++ VACG     T+ V+  G 
Sbjct: 567 ITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQ 626

Query: 397 LYTYXWSKYGQL 432
           ++++    YG+L
Sbjct: 627 VWSWGDGDYGKL 638



 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 45/131 (34%), Positives = 76/131 (58%), Gaps = 2/131 (1%)
 Frame = +1

Query: 46   GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
            G  H  A+T+ G+V SWG   +G+LG  +  +   P+ IQA +   ++ IA G+ H+A +
Sbjct: 3056 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHSAPL 3115

Query: 226  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWR--HTITVSXXGSL 399
            T  G++Y WG G YG LG GD   +  P+ V  + G +++ VACG R   T+ ++  G +
Sbjct: 3116 TSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLV 3175

Query: 400  YTYXWSKYGQL 432
            +++    +G+L
Sbjct: 3176 FSWGDGDFGKL 3186



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 51/139 (36%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
 Frame = +1

Query: 19   GSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
            G  + Q+ACG  D+  LA+T  G V SWG    G+LG G +E   +PQ I+   G  V  
Sbjct: 3151 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3210

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            I  GA+ + A+T+ G ++ WG G Y  LG G       P+ V  + G K+V VA G  H 
Sbjct: 3211 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3270

Query: 373  ITVSXXGSLYTYXWSKYGQ 429
            + V+  G +Y +  + +GQ
Sbjct: 3271 LAVTDSGQVYAWGDNDHGQ 3289



 Score = 88.2 bits (217), Expect = 8e-18
 Identities = 45/135 (33%), Positives = 76/135 (56%), Gaps = 2/135 (1%)
 Frame = +1

Query: 34   QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGA 207
            QL  G+    AVT  G++ + G    G+LG+G TE    P  +++ + + +K +A  +G 
Sbjct: 3991 QLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGG 4050

Query: 208  EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSX 387
            +H  A++ +G++Y WG    G LG G+R+    P  + S+ G ++V VA G  H+  V+ 
Sbjct: 4051 KHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTA 4110

Query: 388  XGSLYTYXWSKYGQL 432
             G LYT+   +YG+L
Sbjct: 4111 AGDLYTWGKGRYGRL 4125



 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 44/141 (31%), Positives = 74/141 (52%), Gaps = 2/141 (1%)
 Frame = +1

Query: 16   RGSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
            +G  +  +ACG  D+  L +T    V SWG    G+LG G ++   +P  I +  G+ V 
Sbjct: 4143 QGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV 4202

Query: 190  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
             +  G++ + A+T+ G +Y WG G Y  LG G  +    P +V  ++G K++ +A G  H
Sbjct: 4203 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4262

Query: 370  TITVSXXGSLYTYXWSKYGQL 432
             +  +  G +YT+  +  GQL
Sbjct: 4263 CVCCTEDGEVYTWGDNDEGQL 4283



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 43/122 (35%), Positives = 66/122 (54%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
            G  + ++ CG    +A+T +G V +WG+    +LG G+ +    P+ +Q  +G  V  IA
Sbjct: 4198 GLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIA 4257

Query: 199  AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
             G+ H    TEDG++Y WG    G LG G  N    P  V++++G K+  VACG  HT+ 
Sbjct: 4258 TGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4317

Query: 379  VS 384
             S
Sbjct: 4318 WS 4319



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 42/122 (34%), Positives = 61/122 (50%)
 Frame = +1

Query: 10   RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
            R  G  + Q+ CG    LA+T +G V +WG+    +LG G+      PQ ++   G  + 
Sbjct: 3202 RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3261

Query: 190  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
             +A GA H  AVT+ G +Y WG   +G  G G       P  V  +EG K+  VACG  H
Sbjct: 3262 HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSH 3321

Query: 370  TI 375
            ++
Sbjct: 3322 SV 3323



 Score = 81.3 bits (199), Expect = 9e-16
 Identities = 39/137 (28%), Positives = 73/137 (53%), Gaps = 2/137 (1%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
            I+ +A G SH   +T +GE+ +WG  + G+LG G     L P+ ++   G  V  +A G+
Sbjct: 3102 IRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3161

Query: 208  E--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 381
                T A+T++G ++ WG G +G LG G      +P+ +  + G  +  + CG + ++ +
Sbjct: 3162 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLAL 3221

Query: 382  SXXGSLYTYXWSKYGQL 432
            +  G ++T+    Y +L
Sbjct: 3222 TKSGVVWTWGKGDYFRL 3238



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 46/138 (33%), Positives = 75/138 (54%), Gaps = 3/138 (2%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL-LPQTIQAFEGISVKMIA-- 198
            + Q+A G     AVT+ G+V S G   NG+LGLG +  ++ +P+ I A     VK +A  
Sbjct: 2995 VVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVH 3054

Query: 199  AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            +G  H  A+T DG ++ WG G  G LG   R +   P  + +++  ++  +A G  H+  
Sbjct: 3055 SGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHSAP 3114

Query: 379  VSXXGSLYTYXWSKYGQL 432
            ++  G LYT+   +YG+L
Sbjct: 3115 LTSSGELYTWGLGEYGRL 3132



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 40/133 (30%), Positives = 72/133 (54%), Gaps = 2/133 (1%)
 Frame = +1

Query: 16   RGSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
            +G  +  +ACG  D+  LAVT  G+V SWG    G+LG G ++    P+ I+  + + V 
Sbjct: 602  KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVI 661

Query: 190  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
             +  G++ + A+T+DG +Y WG G    LG G       P+ +  ++G K++ VA G  H
Sbjct: 662  KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 721

Query: 370  TITVSXXGSLYTY 408
             + ++    ++++
Sbjct: 722  CLVLTEDSEVHSW 734



 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 4/113 (3%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEH 213
           ++ CG    +A+T  G+V SWG+  N +LG GT E    P+ ++  +G  V  +AAG+ H
Sbjct: 662 KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 721

Query: 214 TAAVTEDGDIYGWGWG----RYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
              +TED +++ WG       +  LG+     +  P     ++   +V +ACG
Sbjct: 722 CLVLTEDSEVHSWGSNDQCQHFDTLGV----TKPEPTAFPGLDSKHIVGIACG 770



 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 31/71 (43%), Positives = 42/71 (59%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            RG  I  +A G  HCLAVT +G+V +WG N +GQ G GTT  +  P  +Q  EG  +  +
Sbjct: 3256 RGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRV 3315

Query: 196  AAGAEHTAAVT 228
            A G+ H+ A T
Sbjct: 3316 ACGSSHSVAWT 3326



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 2/130 (1%)
 Frame = +1

Query: 49   DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVT 228
            D   L+   +G +  WG N  GQLG        +P   +A   +    +  G +   AVT
Sbjct: 3944 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4003

Query: 229  EDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--DKMVLVACGWRHTITVSXXGSLY 402
             DG +Y  G+G  G LG+G       P  + S++    K V V  G +H + +S  G +Y
Sbjct: 4004 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4063

Query: 403  TYXWSKYGQL 432
            ++  ++ G+L
Sbjct: 4064 SWGEAEDGKL 4073



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 28/69 (40%), Positives = 38/69 (55%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            +G  +  +A G  HC+  T  GEV +WG N  GQLG GTT     P+ + A +G  V  +
Sbjct: 4249 QGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRV 4308

Query: 196  AAGAEHTAA 222
            A G+ HT A
Sbjct: 4309 ACGSAHTLA 4317



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
 Frame = +1

Query: 70   TMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 249
            T+  +V  WG N   QLG        +P   +    ++V  +A G++   AVT +G +Y 
Sbjct: 2957 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYS 3016

Query: 250  WGWGRYGNLGLGDRNDRF-VPEKVSSVEG--DKMVLVACGWRHTITVSXXGSLYTYXWSK 420
             G    G LGLG  +    +P +++++     K V V  G RH   ++  G ++++    
Sbjct: 3017 CGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3076

Query: 421  YGQL 432
             G+L
Sbjct: 3077 DGKL 3080



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 18/50 (36%), Positives = 25/50 (50%), Gaps = 4/50 (8%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQ----LGLGTTEDSLLP 153
           +G  +  +A G +HCL +T   EV SWG N   Q    LG+   E +  P
Sbjct: 708 QGKKVIDVAAGSTHCLVLTEDSEVHSWGSNDQCQHFDTLGVTKPEPTAFP 757

---

>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  103 bits (256), Expect = 2e-22
 Identities = 48/134 (35%), Positives = 81/134 (60%), Gaps = 1/134 (0%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAE 210
           ++ACG  H L +T  GEV +WG N +GQ+G G+T +  +P+ +    +   V  IA G  
Sbjct: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQM 215

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
            + AV + G++Y WG+   G LGLG   ++  P +V++++G ++  VACG+ HT+ ++  
Sbjct: 216 CSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDE 275

Query: 391 GSLYTYXWSKYGQL 432
           G +Y +  + YGQL
Sbjct: 276 GQIYAWGANSYGQL 289



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 50/132 (37%), Positives = 74/132 (56%), Gaps = 1/132 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           +  +ACG    +AV   GEV  WG N NGQLGLG++ +   P  + A +GI V+ +A G 
Sbjct: 207 VMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGY 266

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVS 384
            HT  +T++G IY WG   YG LG G+++++  P  V  VE D+++ + AC   HT    
Sbjct: 267 AHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPV-VVEKDRIIEIAACHSAHTSAAK 325

Query: 385 XXGSLYTYXWSK 420
             G  + Y W +
Sbjct: 326 SQGG-HVYMWGQ 336



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 46/141 (32%), Positives = 74/141 (52%), Gaps = 3/141 (2%)
 Frame = +1

Query: 19  GSXIKQLACGDS-HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKM 192
           G  I  L+ G   H +  T  GEV +WG N   QLG GTT   L+P  I        V  
Sbjct: 97  GKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIE 156

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 369
           +A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG   
Sbjct: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMC 216

Query: 370 TITVSXXGSLYTYXWSKYGQL 432
           ++ V   G +Y + ++  GQL
Sbjct: 217 SMAVVDTGEVYVWGYNGNGQL 237



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 26/81 (32%), Positives = 46/81 (56%), Gaps = 1/81 (1%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
           +G  ++++ACG +H L +T  G++ +WG N  GQLG G   +   P  +   +   +++ 
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIA 314

Query: 196 AAGAEHT-AAVTEDGDIYGWG 255
           A  + HT AA ++ G +Y WG
Sbjct: 315 ACHSAHTSAAKSQGGHVYMWG 335

---

>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  102 bits (255), Expect = 3e-22
 Identities = 48/134 (35%), Positives = 81/134 (60%), Gaps = 1/134 (0%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAE 210
           ++ACG  H L +T  GEV +WG N +GQ+G G+T +  +P+ +    +   V  IA G  
Sbjct: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQM 215

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
            + AV + G++Y WG+   G LGLG   ++  P +V++++G ++  VACG+ HT+ ++  
Sbjct: 216 CSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDE 275

Query: 391 GSLYTYXWSKYGQL 432
           G +Y +  + YGQL
Sbjct: 276 GQIYAWGANSYGQL 289



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 50/132 (37%), Positives = 74/132 (56%), Gaps = 1/132 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           +  +ACG    +AV   GEV  WG N NGQLGLG++ +   P  + A +GI V+ +A G 
Sbjct: 207 VMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGY 266

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVS 384
            HT  +T++G IY WG   YG LG G+++++  P  V  VE D+++ + AC   HT    
Sbjct: 267 AHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPV-VVEKDRIIEIAACHSAHTSAAK 325

Query: 385 XXGSLYTYXWSK 420
             G  + Y W +
Sbjct: 326 TQGG-HVYMWGQ 336



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 46/141 (32%), Positives = 74/141 (52%), Gaps = 3/141 (2%)
 Frame = +1

Query: 19  GSXIKQLACGDS-HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKM 192
           G  I  L+ G   H +  T  GEV +WG N   QLG GTT   L+P  I        V  
Sbjct: 97  GKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIE 156

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 369
           +A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG   
Sbjct: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMC 216

Query: 370 TITVSXXGSLYTYXWSKYGQL 432
           ++ V   G +Y + ++  GQL
Sbjct: 217 SMAVVDTGEVYVWGYNGNGQL 237



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 27/81 (33%), Positives = 46/81 (56%), Gaps = 1/81 (1%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
           +G  ++++ACG +H L +T  G++ +WG N  GQLG G   +   P  +   +   +++ 
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIA 314

Query: 196 AAGAEHT-AAVTEDGDIYGWG 255
           A  + HT AA T+ G +Y WG
Sbjct: 315 ACHSAHTSAAKTQGGHVYMWG 335

---

>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score =  101 bits (252), Expect = 7e-22
 Identities = 48/134 (35%), Positives = 81/134 (60%), Gaps = 1/134 (0%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAE 210
           ++ACG  H L +T  GEV +WG N +GQ+G G+T +  +P+ +    +   V  IA G  
Sbjct: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
              AV + G++Y WG+   G LGLG+  ++  P +V++++G ++  VACG+ HT+ ++  
Sbjct: 216 CCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDE 275

Query: 391 GSLYTYXWSKYGQL 432
           G +Y +  + YGQL
Sbjct: 276 GQVYAWGANSYGQL 289



 Score =  101 bits (251), Expect = 9e-22
 Identities = 50/129 (38%), Positives = 74/129 (57%), Gaps = 1/129 (0%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           +ACG   C+AV   GEV  WG N NGQLGLG + +   P  + A +GI V+ +A G  HT
Sbjct: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSXXG 393
             +T++G +Y WG   YG LG G+++++  P  V +VE D+++ + AC   HT      G
Sbjct: 270 LVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQG 328

Query: 394 SLYTYXWSK 420
             + Y W +
Sbjct: 329 G-HVYMWGQ 336



 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 45/140 (32%), Positives = 73/140 (52%), Gaps = 6/140 (4%)
 Frame = +1

Query: 31  KQLAC----GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMI 195
           K++AC       H +  T  GEV +WG N   QLG GTT   L+P  I        V  +
Sbjct: 98  KKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEV 157

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHT 372
           A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG    
Sbjct: 158 ACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCC 217

Query: 373 ITVSXXGSLYTYXWSKYGQL 432
           + V   G +Y + ++  GQL
Sbjct: 218 MAVVDTGEVYVWGYNGNGQL 237



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 28/81 (34%), Positives = 46/81 (56%), Gaps = 1/81 (1%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
           +G  ++++ACG +H L +T  G+V +WG N  GQLG G   +   P  +   +   +++ 
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIA 314

Query: 196 AAGAEHT-AAVTEDGDIYGWG 255
           A  + HT AA T+ G +Y WG
Sbjct: 315 ACHSTHTSAAKTQGGHVYMWG 335

---

>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score =  101 bits (252), Expect = 7e-22
 Identities = 48/134 (35%), Positives = 81/134 (60%), Gaps = 1/134 (0%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAE 210
           ++ACG  H L +T  GEV +WG N +GQ+G G+T +  +P+ +    +   V  IA G  
Sbjct: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
              AV + G++Y WG+   G LGLG+  ++  P +V++++G ++  VACG+ HT+ ++  
Sbjct: 216 CCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDE 275

Query: 391 GSLYTYXWSKYGQL 432
           G +Y +  + YGQL
Sbjct: 276 GQVYAWGANSYGQL 289



 Score =  101 bits (251), Expect = 9e-22
 Identities = 50/129 (38%), Positives = 74/129 (57%), Gaps = 1/129 (0%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           +ACG   C+AV   GEV  WG N NGQLGLG + +   P  + A +GI V+ +A G  HT
Sbjct: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSXXG 393
             +T++G +Y WG   YG LG G+++++  P  V +VE D+++ + AC   HT      G
Sbjct: 270 LVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQG 328

Query: 394 SLYTYXWSK 420
             + Y W +
Sbjct: 329 G-HVYMWGQ 336



 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 45/140 (32%), Positives = 73/140 (52%), Gaps = 6/140 (4%)
 Frame = +1

Query: 31  KQLAC----GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMI 195
           K++AC       H +  T  GEV +WG N   QLG GTT   L+P  I        V  +
Sbjct: 98  KKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEV 157

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHT 372
           A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG    
Sbjct: 158 ACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCC 217

Query: 373 ITVSXXGSLYTYXWSKYGQL 432
           + V   G +Y + ++  GQL
Sbjct: 218 MAVVDTGEVYVWGYNGNGQL 237



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 28/81 (34%), Positives = 46/81 (56%), Gaps = 1/81 (1%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
           +G  ++++ACG +H L +T  G+V +WG N  GQLG G   +   P  +   +   +++ 
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIA 314

Query: 196 AAGAEHT-AAVTEDGDIYGWG 255
           A  + HT AA T+ G +Y WG
Sbjct: 315 ACHSTHTSAAKTQGGHVYMWG 335

---

>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  100 bits (250), Expect = 1e-21
 Identities = 49/136 (36%), Positives = 80/136 (58%), Gaps = 2/136 (1%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
            G  +  +ACG +H  A+T +G VL+WG+ + G+LG G +ED L P+ ++A  G     IA
Sbjct: 4187 GMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIA 4246

Query: 199  AGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
             G+    T  +T+D +++ WG G YG LG G  +   +P K+ S+ G  +V V CG + +
Sbjct: 4247 CGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFS 4306

Query: 373  ITVSXXGSLYTYXWSK 420
            + ++  G++YT  W K
Sbjct: 4307 VALTKSGAVYT--WGK 4320



 Score =  100 bits (249), Expect = 1e-21
 Identities = 45/131 (34%), Positives = 80/131 (61%), Gaps = 2/131 (1%)
 Frame = +1

Query: 46   GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
            G  H LA+T+ G+V SWG  ++G+LG G       P+ ++A     ++ +A G+ H+AA+
Sbjct: 3081 GGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAI 3140

Query: 226  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWR--HTITVSXXGSL 399
            +  G++Y WG G YG LG GD   +  P+ V+++ G ++V VACG R   T+ ++  G++
Sbjct: 3141 SSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAV 3200

Query: 400  YTYXWSKYGQL 432
            +++    +G+L
Sbjct: 3201 FSWGDGDFGKL 3211



 Score = 99.0 bits (245), Expect = 4e-21
 Identities = 48/131 (36%), Positives = 77/131 (58%), Gaps = 2/131 (1%)
 Frame = +1

Query: 46   GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
            G  HCLA+T  GEV +WG  ++G+LG G       P+ ++   G+SV  IA G+ H+AA+
Sbjct: 4144 GGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAI 4203

Query: 226  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSXXGSL 399
            T  G +  WG GRYG LG GD  D+  P+ V ++ G + + +ACG     T+ ++   ++
Sbjct: 4204 TASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNV 4263

Query: 400  YTYXWSKYGQL 432
            +++    YG+L
Sbjct: 4264 WSWGDGDYGKL 4274



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 45/141 (31%), Positives = 75/141 (53%), Gaps = 2/141 (1%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            R   I+ +ACG SH  A++  GE+ +WG  + G+LG G     L P+ + A  G  V  +
Sbjct: 3123 RAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQV 3182

Query: 196  AAGAE--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
            A G+    T A+TEDG ++ WG G +G LG G       P ++  + G  +V + CG + 
Sbjct: 3183 ACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQF 3242

Query: 370  TITVSXXGSLYTYXWSKYGQL 432
            ++ ++  G ++T+    Y +L
Sbjct: 3243 SLALTRAGEVWTWGKGDYYRL 3263



 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 49/139 (35%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
 Frame = +1

Query: 19   GSXIKQLACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
            G  + Q+ACG  D+  LA+T  G V SWG    G+LG G +E S  P  I+   GI V  
Sbjct: 3176 GRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQ 3235

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            I  GA+ + A+T  G+++ WG G Y  LG G       P+ +  + G +++ VA G  H 
Sbjct: 3236 IECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHC 3295

Query: 373  ITVSXXGSLYTYXWSKYGQ 429
            + V+  G +Y +  + +GQ
Sbjct: 3296 LAVTDAGQVYAWGDNDHGQ 3314



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 48/134 (35%), Positives = 70/134 (52%), Gaps = 2/134 (1%)
 Frame = +1

Query: 37   LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGAE 210
            +A G      V+  G+V + G   NG+LGLG T +  LP  +       VK +A  +G +
Sbjct: 3024 IAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK 3083

Query: 211  HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
            H  A+T DG ++ WG G  G LG G+R     P  V ++   K+  VACG  H+  +S  
Sbjct: 3084 HALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQ 3143

Query: 391  GSLYTYXWSKYGQL 432
            G LYT+   +YG+L
Sbjct: 3144 GELYTWGLGEYGRL 3157



 Score = 88.2 bits (217), Expect = 8e-18
 Identities = 45/134 (33%), Positives = 75/134 (55%), Gaps = 2/134 (1%)
 Frame = +1

Query: 37   LACG--DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 210
            +ACG  D+  L +T    V SWG    G+LG G ++   LP  I++  G+ V  +  G++
Sbjct: 4245 IACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQ 4304

Query: 211  HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
             + A+T+ G +Y WG G +  LG G  +    P+KV++++G K++ +A G  H +  S  
Sbjct: 4305 FSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDS 4364

Query: 391  GSLYTYXWSKYGQL 432
            G +YT+  +  GQL
Sbjct: 4365 GEVYTWGDNDEGQL 4378



 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 43/135 (31%), Positives = 75/135 (55%), Gaps = 2/135 (1%)
 Frame = +1

Query: 34   QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGA 207
            QLA G+    AVT  G++ + G    G+LG+G ++   +P  + + + + VK +A  +G 
Sbjct: 4086 QLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGG 4145

Query: 208  EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSX 387
            +H  A+T +G++Y WG G  G LG G+R     P+ V  + G  +  +ACG  H+  ++ 
Sbjct: 4146 KHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITA 4205

Query: 388  XGSLYTYXWSKYGQL 432
             G + T+   +YG+L
Sbjct: 4206 SGHVLTWGKGRYGRL 4220



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 45/133 (33%), Positives = 71/133 (53%), Gaps = 2/133 (1%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
            ++ + CG S+  A+T  G +L+WGR    +LG G ++D  LP  + A     V  +A G+
Sbjct: 670  VQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGS 729

Query: 208  --EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 381
               H+ A+T +G ++ WG G YG LG G+ N    P  V S+   ++  V  G + ++ +
Sbjct: 730  GDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESL--PRVQRVFAGSQFSVAL 787

Query: 382  SXXGSLYTYXWSK 420
            S  G LYT  W K
Sbjct: 788  SSEGQLYT--WGK 798



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 38/122 (31%), Positives = 65/122 (53%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
            G  + ++ CG    +A+T +G V +WG+    +LG G+ +    P+ + A +G  +  IA
Sbjct: 4293 GLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIA 4352

Query: 199  AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
             G+ H  A ++ G++Y WG    G LG G       P  V++++G  +V V CG  HT+ 
Sbjct: 4353 TGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLA 4412

Query: 379  VS 384
            +S
Sbjct: 4413 LS 4414



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 44/122 (36%), Positives = 60/122 (49%)
 Frame = +1

Query: 10   RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK 189
            R  G  + Q+ CG    LA+T AGEV +WG+    +LG G  +    PQ I    G  V 
Sbjct: 3227 RLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVI 3286

Query: 190  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH 369
             +A GA H  AVT+ G +Y WG   +G  G G+      P  V  ++   +  VACG  H
Sbjct: 3287 HVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSH 3346

Query: 370  TI 375
            +I
Sbjct: 3347 SI 3348



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 41/132 (31%), Positives = 67/132 (50%), Gaps = 2/132 (1%)
 Frame = +1

Query: 43   CGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAA 222
            C   H LA+       SWG  ++ +LG G T    +P  I A E   V+ +  G  ++AA
Sbjct: 623  CEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAA 682

Query: 223  VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSXXGS 396
            +T  G++  WG G Y  LG G+ +DR +P  V ++    +V VA G    H++ ++  G 
Sbjct: 683  ITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGL 742

Query: 397  LYTYXWSKYGQL 432
            ++ +    YG+L
Sbjct: 743  VFAWGDGDYGKL 754



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 36/130 (27%), Positives = 59/130 (45%), Gaps = 2/130 (1%)
 Frame = +1

Query: 49   DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVT 228
            D   L+   A  +  WG N  GQLG         P   +A   +    +A G +   AVT
Sbjct: 4039 DDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVT 4098

Query: 229  EDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--DKMVLVACGWRHTITVSXXGSLY 402
             DG ++  G+G  G LG+G  +   +P  + S++    K V V  G +H + ++  G +Y
Sbjct: 4099 PDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVY 4158

Query: 403  TYXWSKYGQL 432
             +   + G+L
Sbjct: 4159 AWGEGEDGKL 4168



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 27/69 (39%), Positives = 39/69 (56%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            RG  +  +A G  HCLAVT AG+V +WG N +GQ G G T  +  P  +   + + V  +
Sbjct: 3281 RGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRV 3340

Query: 196  AAGAEHTAA 222
            A G+ H+ A
Sbjct: 3341 ACGSSHSIA 3349



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 26/71 (36%), Positives = 40/71 (56%)
 Frame = +1

Query: 16   RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
            +G  I  +A G  HC+A + +GEV +WG N  GQLG GT      P+ + A +G  +  +
Sbjct: 4344 QGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKV 4403

Query: 196  AAGAEHTAAVT 228
              G+ HT A++
Sbjct: 4404 TCGSAHTLALS 4414



 Score = 37.0 bits (84), Expect = 0.020
 Identities = 15/78 (19%), Positives = 40/78 (51%), Gaps = 2/78 (2%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQ--NGQLGLGTTEDSLLPQTIQAFEGISVKMIAA 201
            ++++  G    +A++  G++ +WG+      QL   + +   +P+ + + +   +  +A 
Sbjct: 774  VQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAV 833

Query: 202  GAEHTAAVTEDGDIYGWG 255
               H  A++  G+++GWG
Sbjct: 834  SVAHCLALSSSGEVFGWG 851



 Score = 35.4 bits (80), Expect = 0.059
 Identities = 14/31 (45%), Positives = 21/31 (67%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQL 120
           I  +A   +HCLA++ +GEV  WGRN + Q+
Sbjct: 828 IVDVAVSVAHCLALSSSGEVFGWGRNDSQQI 858

---

>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score =  100 bits (249), Expect = 1e-21
 Identities = 50/144 (34%), Positives = 80/144 (55%), Gaps = 4/144 (2%)
 Frame = +1

Query: 13  CRGSXIKQL---ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI-QAFEGI 180
           C    IKQ+   ACG  H +A+   GE+ +WG N  GQ+G G+T +   P+ +       
Sbjct: 122 CTNLLIKQVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTK 181

Query: 181 SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
            V  IA G   + AV + G++YGWG+   G LGLG+  ++  P +V+++ G  +  + CG
Sbjct: 182 RVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCG 241

Query: 361 WRHTITVSXXGSLYTYXWSKYGQL 432
           + HT+ ++  G LY +  + YGQL
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQL 265



 Score = 98.2 bits (243), Expect = 7e-21
 Identities = 49/132 (37%), Positives = 72/132 (54%), Gaps = 1/132 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           +  +ACG +  +AV  +GEV  WG N NGQLGLG   + L P  + A  G+ V  I  G 
Sbjct: 183 VVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGY 242

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVS 384
            HT A+T++G +Y WG   YG LG G +N+   P ++  VE ++++ + AC   HT    
Sbjct: 243 AHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQI-MVEKERVIEIAACHSTHTSAAK 301

Query: 385 XXGSLYTYXWSK 420
             G  + Y W +
Sbjct: 302 TQGG-HVYMWGQ 312



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 4/142 (2%)
 Frame = +1

Query: 19  GSXIKQLACGDS--HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
           GS  K    G S    + VT   EV  +G N +  LG G  + +L+P+ ++A  G  +K 
Sbjct: 19  GSIRKACVFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKS 78

Query: 193 IAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWR 366
           ++ G+  H    TEDG +Y WG   Y  LG G  N    P +V +    K V+ VACG  
Sbjct: 79  LSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSH 138

Query: 367 HTITVSXXGSLYTYXWSKYGQL 432
           H++ ++  G L+ + ++  GQ+
Sbjct: 139 HSMALAADGELFAWGYNNCGQV 160



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 30/80 (37%), Positives = 45/80 (56%), Gaps = 1/80 (1%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  + Q+ CG +H LA+T  G + +WG N  GQLG G+  + L P  I   +   +++ A
Sbjct: 232 GMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAA 291

Query: 199 AGAEHT-AAVTEDGDIYGWG 255
             + HT AA T+ G +Y WG
Sbjct: 292 CHSTHTSAAKTQGGHVYMWG 311

---

>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 99.4 bits (246), Expect = 3e-21
 Identities = 51/144 (35%), Positives = 81/144 (56%), Gaps = 4/144 (2%)
 Frame = +1

Query: 13  CRGSXIKQL---ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS 183
           C    IKQ+   ACG  H +A+   GEV +WG N  GQ+G G+T +   P+ +     I 
Sbjct: 122 CTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIK 181

Query: 184 -VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
            V  IA G   + AV ++G++YGWG+   G LGLG+  ++  P +V+++    +  + CG
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241

Query: 361 WRHTITVSXXGSLYTYXWSKYGQL 432
           + HT+ ++  G LY +  + YGQL
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQL 265



 Score = 95.1 bits (235), Expect = 6e-20
 Identities = 49/129 (37%), Positives = 69/129 (53%), Gaps = 1/129 (0%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           +ACG +  +AV   GEV  WG N NGQLGLG   + L P  + A   + V  I  G  HT
Sbjct: 186 IACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHT 245

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSXXG 393
            A+T++G +Y WG   YG LG G++N+   P  +  VE +++V + AC   HT      G
Sbjct: 246 LALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI-MVEKERVVEIAACHSAHTSAAKTQG 304

Query: 394 SLYTYXWSK 420
             + Y W +
Sbjct: 305 G-HVYMWGQ 312



 Score = 72.8 bits (177), Expect = 3e-13
 Identities = 40/129 (31%), Positives = 69/129 (53%), Gaps = 2/129 (1%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA-EHTAAVT 228
           S  L VT   EV  +G N +  LG G  + +L+P+ ++   G  +K ++ G+  H    T
Sbjct: 32  SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLST 91

Query: 229 EDGDIYGWGWGRYGNLGLGDRNDRFVPEKV-SSVEGDKMVLVACGWRHTITVSXXGSLYT 405
           EDG +Y WG   Y  LG G  N    P +V +++   ++V VACG  H++ ++  G ++ 
Sbjct: 92  EDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFA 151

Query: 406 YXWSKYGQL 432
           + ++  GQ+
Sbjct: 152 WGYNNCGQV 160



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 30/77 (38%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           + Q+ CG +H LA+T  G + +WG N  GQLG G   + L P  I   +   V++ A  +
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHS 294

Query: 208 EHT-AAVTEDGDIYGWG 255
            HT AA T+ G +Y WG
Sbjct: 295 AHTSAAKTQGGHVYMWG 311



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
 Frame = +1

Query: 145 LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 324
           L PQ I +     V      A     VT++ +++ +G      LG GD     VP+K+  
Sbjct: 13  LSPQEIASIRKACV--FGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG 70

Query: 325 VEGDKMVLVACG-WRHTITVSXXGSLYTYXWSKYGQL 432
           + G K+  ++ G   H +  +  G +Y +  + Y QL
Sbjct: 71  LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQL 107

---

>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 48/140 (34%), Positives = 77/140 (55%), Gaps = 2/140 (1%)
 Frame = +1

Query: 19  GSXIKQLACGD--SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
           G  ++ +A G   +H L +T+ G++ SWGRN  GQLG G  +   +P+ I++ +G     
Sbjct: 138 GVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVH 197

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            A G  HT A+TE+G +Y +G  + G LGLG++ D           G  +  VACG   +
Sbjct: 198 AACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQPITKVACGAEFS 257

Query: 373 ITVSXXGSLYTYXWSKYGQL 432
           + +   G+LY++   +YGQL
Sbjct: 258 MIMDCKGNLYSFGCPEYGQL 277



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 41/165 (24%), Positives = 72/165 (43%), Gaps = 26/165 (15%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 195
           +G      ACG +H LA+T  G V ++G N+ GQLGLG   D++       + G  +  +
Sbjct: 191 KGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQPITKV 250

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL--------- 348
           A GAE +  +   G++Y +G   YG   LG  +D     +   +E D  ++         
Sbjct: 251 ACGAEFSMIMDCKGNLYSFGCPEYGQ--LGHNSDGKYIARAQRIEYDCELIARRIAIFIE 308

Query: 349 -----------------VACGWRHTITVSXXGSLYTYXWSKYGQL 432
                            +ACG  H++ +     ++++ +  YG+L
Sbjct: 309 KTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRL 353



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 2/131 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE--GISVKMIAA 201
           ++ +ACG +H L +     V SWG    G+LG     D ++P+ ++ F+  G     I A
Sbjct: 323 VRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIYA 382

Query: 202 GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 381
           GA  + AV+E G ++ WG           R+    P+ V  + G K+  +ACG + +I V
Sbjct: 383 GATCSFAVSEMGGLFFWGATN------TSRDSTMYPKAVQDLCGWKVRSLACG-KSSIIV 435

Query: 382 SXXGSLYTYXW 414
           +   S  T  W
Sbjct: 436 AADES--TISW 444



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 26/154 (16%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT------------EDSLLPQTI 162
           G  I ++ACG    + +   G + S+G  + GQLG  +             +  L+ + I
Sbjct: 244 GQPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRI 303

Query: 163 QAF------------EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV 306
             F              + V+ IA G  H+  +     ++ WG+G YG LG  ++ D  V
Sbjct: 304 AIFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMV 363

Query: 307 PE--KVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
           P   K+    G     +  G   +  VS  G L+
Sbjct: 364 PRLVKLFDFPGRGAAQIYAGATCSFAVSEMGGLF 397



 Score = 36.2 bits (82), Expect = 0.035
 Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQN-GQLGLGTTE--DSLLPQTIQAFEGISVK 189
           G  ++ LACG S  + V      +SWG +   G+LG G  +   S   Q ++  +GI   
Sbjct: 420 GWKVRSLACGKSSII-VAADESTISWGPSPTFGELGYGDNKAKSSTTAQEVKTLDGIYSD 478

Query: 190 MIAAGAEHTAAVTED 234
            +  G  HT  V  D
Sbjct: 479 QVIMGNSHTLVVARD 493

---

>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 91.3 bits (225), Expect = 9e-19
 Identities = 46/127 (36%), Positives = 69/127 (54%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTE 231
           +H L +T  G++ SWGRN  GQLG G T+    P+ I+      +   A G  HT A+TE
Sbjct: 133 AHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTE 192

Query: 232 DGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYX 411
           +G +Y +G  + G LG G++ D  +        G  +V VACG   ++ V   G+LY++ 
Sbjct: 193 NGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACGAEFSMIVDCKGNLYSFG 252

Query: 412 WSKYGQL 432
             +YGQL
Sbjct: 253 CPEYGQL 259



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 49/156 (31%), Positives = 74/156 (47%), Gaps = 25/156 (16%)
 Frame = +1

Query: 40  ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAGAEHT 216
           ACG +H LA+T  G V ++G N+ GQLG G   D++L P TIQ + G  +  +A GAE +
Sbjct: 181 ACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAEFS 239

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRND------------RFVPEKVS---SVEGDKMVL- 348
             V   G++Y +G   YG LG                    +P +V+       D  VL 
Sbjct: 240 MIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLP 299

Query: 349 --------VACGWRHTITVSXXGSLYTYXWSKYGQL 432
                   VACG  HT+ +     ++++ +  YG+L
Sbjct: 300 VPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRL 335



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 38/154 (24%), Positives = 65/154 (42%), Gaps = 26/154 (16%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT------------EDSLLPQTI 162
           G  I ++ACG    + V   G + S+G  + GQLG  +             +  L+P+ +
Sbjct: 226 GQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRV 285

Query: 163 QAF------------EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV 306
             F              +  + +A GA HT  +     ++ WG+G YG LG  ++ D  V
Sbjct: 286 AIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 345

Query: 307 PE--KVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
           P   K+    G     + CG++ +  +S  G L+
Sbjct: 346 PRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLF 379



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 2/96 (2%)
 Frame = +1

Query: 151 PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 324
           P        + V  + +G  A H+  +T +G ++ WG    G LG GD      P+ +  
Sbjct: 112 PHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEG 171

Query: 325 VEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
           +  + +V  ACG  HT+ ++  G++YT+  +K GQL
Sbjct: 172 LGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQL 207

---

>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 43/127 (33%), Positives = 71/127 (55%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTE 231
           +H L +T  G++ SWGRN+ GQLG G T+    P+ I+A    ++ + A G  HT A+T+
Sbjct: 158 AHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTD 217

Query: 232 DGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYX 411
            G ++ +G  + G LGLG++ D           G  +  +ACG   ++ +   G+LY++ 
Sbjct: 218 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSFG 277

Query: 412 WSKYGQL 432
             +YGQL
Sbjct: 278 CPEYGQL 284



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 44/155 (28%), Positives = 72/155 (46%), Gaps = 24/155 (15%)
 Frame = +1

Query: 40  ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTA 219
           ACG +H LA+T  G V ++G N+ GQLGLG   D++       + G  +  +A GAE + 
Sbjct: 206 ACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM 265

Query: 220 AVTEDGDIYGWGWGRYGNLGLG------------DRNDRFVPEKVS---SVEGDKMVL-- 348
            +   G++Y +G   YG LG              + +   VP +V+       D  +L  
Sbjct: 266 LMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPV 325

Query: 349 -------VACGWRHTITVSXXGSLYTYXWSKYGQL 432
                  VACG  HT+ +     ++++ +  YG+L
Sbjct: 326 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRL 360



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 29/96 (30%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
 Frame = +1

Query: 151 PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 324
           P       G+ V+ + +G  A H+  +T +G ++ WG    G LG GD      P  + +
Sbjct: 137 PHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEA 196

Query: 325 VEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
           +  + +VL ACG  HT+ ++  GS++ +  +K GQL
Sbjct: 197 LSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQL 232



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 38/154 (24%), Positives = 64/154 (41%), Gaps = 26/154 (16%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT------------EDSLLPQTI 162
           G  I ++ACG    + +   G + S+G  + GQLG  +             +  L+P+ +
Sbjct: 251 GQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 310

Query: 163 QAF------------EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV 306
             F              + V+ +A GA HT  +     ++ WG+G YG LG  ++ D  V
Sbjct: 311 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 370

Query: 307 PE--KVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
           P   K+    G     +  G+  +  VS  G L+
Sbjct: 371 PRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLF 404

---

>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 49/136 (36%), Positives = 78/136 (57%), Gaps = 1/136 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTED-SLLPQTIQAFEGISVKMIAAG 204
           +K  ACG +H L  T  G V + G N  GQLGLG T+D     Q +      ++K ++AG
Sbjct: 89  VKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAG 148

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 384
           A  +AA+TEDG ++ WG    G +GL D+++  +P +V+   G  +  ++CG+ H+  V+
Sbjct: 149 ANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVT--VGKPISWISCGYYHSAFVT 206

Query: 385 XXGSLYTYXWSKYGQL 432
             G LYT+   + G+L
Sbjct: 207 MDGELYTFGEPENGKL 222



 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 47/141 (33%), Positives = 78/141 (55%), Gaps = 3/141 (2%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI- 195
           G  I  ++CG  H   VTM GE+ ++G  +NG+LGL   E  +  ++ Q   GI  ++I 
Sbjct: 189 GKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGL-PNELLMNHRSPQRVLGIPERVIQ 247

Query: 196 -AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVLVACGWRH 369
            A G  HT  +TE   +Y +G G++G LGLG    +   P+ +  ++  K+  ++CG  H
Sbjct: 248 VACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENH 306

Query: 370 TITVSXXGSLYTYXWSKYGQL 432
           T  ++  G LYT+   ++G+L
Sbjct: 307 TALMTELGLLYTFGDGRHGKL 327



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 43/133 (32%), Positives = 66/133 (49%), Gaps = 1/133 (0%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           L+CGD H   VT   ++  +G N  GQLGLG+    + P  I+A +   VK+ A G  HT
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 99

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDR-FVPEKVSSVEGDKMVLVACGWRHTITVSXXG 393
              T+ G +Y  G    G LGLGD +DR    + V     D +  ++ G   +  ++  G
Sbjct: 100 LVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDG 159

Query: 394 SLYTYXWSKYGQL 432
            L+ +  +  GQ+
Sbjct: 160 KLFMWGDNSEGQI 172



 Score = 68.2 bits (165), Expect = 8e-12
 Identities = 44/117 (37%), Positives = 66/117 (56%), Gaps = 3/117 (2%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAE 210
           Q+ACG  H + +T    V ++G  Q GQLGLGT   ++  P+ I+  +   +  I+ G  
Sbjct: 247 QVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGEN 305

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTI 375
           HTA +TE G +Y +G GR+G LGLG  N  ++F P   S+     + L+ACG  H +
Sbjct: 306 HTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCHML 362



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
 Frame = +1

Query: 10  RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGIS 183
           R +   I  ++CG++H   +T  G + ++G  ++G+LGLG     +   P     F   +
Sbjct: 291 RIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFA 350

Query: 184 VKMIAAGAEH 213
           V++IA G  H
Sbjct: 351 VQLIACGGCH 360

---

>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 88.2 bits (217), Expect = 8e-18
 Identities = 49/136 (36%), Positives = 78/136 (57%), Gaps = 1/136 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAG 204
           +K  ACG +H L  T  G+V + G N  GQLGLG TE+      I  F     +K ++AG
Sbjct: 89  VKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAG 148

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 384
           +  +AA+TEDG+++ WG    G +GL +  +  VP++V+   G  +  ++CG+ H+  V+
Sbjct: 149 SNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVT--VGKPISWISCGYYHSAFVT 206

Query: 385 XXGSLYTYXWSKYGQL 432
             G LYT+   + G+L
Sbjct: 207 TEGQLYTFGEPECGKL 222



 Score = 81.6 bits (200), Expect = 7e-16
 Identities = 51/138 (36%), Positives = 78/138 (56%), Gaps = 3/138 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           IKQL+ G +   A+T  GE+  WG N  GQ+GL    +  +PQ  Q   G  +  I+ G 
Sbjct: 142 IKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQ--QVTVGKPISWISCGY 199

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDR---NDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            H+A VT +G +Y +G    G LGL ++   N R +P+ V  + G K+V VACG  HT+ 
Sbjct: 200 YHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHR-MPQPVPGIPG-KVVQVACGGGHTVV 257

Query: 379 VSXXGSLYTYXWSKYGQL 432
           ++   ++YT+   ++GQL
Sbjct: 258 LTEK-AVYTFGLGQFGQL 274



 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 44/141 (31%), Positives = 75/141 (53%), Gaps = 3/141 (2%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT--EDSLLPQTIQAFEGISVKM 192
           G  I  ++CG  H   VT  G++ ++G  + G+LGL      +  +PQ +    G  V  
Sbjct: 189 GKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPG-KVVQ 247

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVLVACGWRH 369
           +A G  HT  +TE   +Y +G G++G LGLG    +  VP+ +  ++  K+  +ACG  H
Sbjct: 248 VACGGGHTVVLTEKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENH 306

Query: 370 TITVSXXGSLYTYXWSKYGQL 432
           T  ++  G +YT+   ++G+L
Sbjct: 307 TALITDMGLMYTFGDGRHGKL 327



 Score = 75.5 bits (184), Expect = 5e-14
 Identities = 45/119 (37%), Positives = 70/119 (58%), Gaps = 3/119 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAG 204
           + Q+ACG  H + +T    V ++G  Q GQLGLGT   ++ +P+ I+  +   +  IA G
Sbjct: 245 VVQVACGGGHTVVLTEKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACG 303

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTI 375
             HTA +T+ G +Y +G GR+G LGLG  N  ++F+P   S+     + LV+CG  HT+
Sbjct: 304 ENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCGGCHTL 362



 Score = 71.6 bits (174), Expect = 7e-13
 Identities = 42/133 (31%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           L+CGD H   VT   ++  +G N  GQLGLG+      P  ++A +   VK  A G  HT
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHT 99

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD-KMVLVACGWRHTITVSXXG 393
              TE G +Y  G    G LGLGD  +R     +S      K+  ++ G   +  ++  G
Sbjct: 100 LVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDG 159

Query: 394 SLYTYXWSKYGQL 432
            L+ +  +  GQ+
Sbjct: 160 ELFMWGDNSEGQI 172

---

>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 43/127 (33%), Positives = 68/127 (53%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTE 231
           +H L +T  G++ SWGRN+ GQLG G T+    P+ I+      +   A G  HT A+TE
Sbjct: 160 AHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTE 219

Query: 232 DGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYX 411
            G ++ +G  + G LGLG++ D           G  +  +ACG   ++ +   G+LY++ 
Sbjct: 220 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFG 279

Query: 412 WSKYGQL 432
             +YGQL
Sbjct: 280 CPEYGQL 286



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/159 (28%), Positives = 73/159 (45%), Gaps = 24/159 (15%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           I   ACG +H LA+T  G V ++G N+ GQLGLG   D++       + G  +  +A GA
Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGA 263

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLG------------DRNDRFVPEKVS---SVEGDKM 342
           E +  +   G++Y +G   YG LG              + +   VP +V+       D  
Sbjct: 264 EFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQ 323

Query: 343 VL---------VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           +L         VACG  HT+ +     ++++ +  YG+L
Sbjct: 324 ILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRL 362



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 2/96 (2%)
 Frame = +1

Query: 151 PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 324
           P       G+ V+ + +G  A H+  +T +G ++ WG    G LG GD      P  +  
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198

Query: 325 VEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
           +  + +V  ACG  HT+ ++  GS++ +  +K GQL
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQL 234



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 38/154 (24%), Positives = 64/154 (41%), Gaps = 26/154 (16%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT------------EDSLLPQTI 162
           G  I ++ACG    + +   G + S+G  + GQLG  +             +  L+P+ +
Sbjct: 253 GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 312

Query: 163 QAF------------EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV 306
             F              + V+ +A GA HT  +     ++ WG+G YG LG  ++ D  V
Sbjct: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 372

Query: 307 PE--KVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
           P   K+    G     +  G+  +  VS  G L+
Sbjct: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLF 406

---

>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 43/138 (31%), Positives = 70/138 (50%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  IK +ACGD     +T  G ++++G   NG LG G   D   P  ++A  G  +  +A
Sbjct: 396 GVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVA 455

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            GA H  A++ DG+++ WG G  G LGLG R     P++V    G +   V CG   ++ 
Sbjct: 456 CGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMI 515

Query: 379 VSXXGSLYTYXWSKYGQL 432
           ++  G +     +++ +L
Sbjct: 516 LTSPGRVLACGSNRFNKL 533



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 43/152 (28%), Positives = 72/152 (47%), Gaps = 14/152 (9%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  + Q+ACG SH LA++  GE+ +WGR   G+LGLGT E    PQ +    G   + + 
Sbjct: 448 GYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVV 507

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLG--------------DRNDRFVPEKVSSVEGD 336
            G + +  +T  G +   G  R+  LGL               +    F P   + ++ +
Sbjct: 508 CGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQE 567

Query: 337 KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
            ++ V  G  H+  ++  G  YT+  +++GQL
Sbjct: 568 PLLCVDLGTAHSAAITASGDCYTFGSNQHGQL 599



 Score = 72.4 bits (176), Expect = 4e-13
 Identities = 46/153 (30%), Positives = 74/153 (48%), Gaps = 15/153 (9%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLG--TTEDSLLPQTIQAFEGISVKM 192
           G   +++ CG    + +T  G VL+ G N+  +LGL   + ++  +P   Q  E +S   
Sbjct: 500 GQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQ-QVEEALSFTP 558

Query: 193 IAA-------------GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 333
           + +             G  H+AA+T  GD Y +G  ++G LG   R     P +V  +EG
Sbjct: 559 LGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEG 618

Query: 334 DKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
            KMV+VACG   T+ V   G +Y++     G+L
Sbjct: 619 IKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRL 651



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 39/112 (34%), Positives = 58/112 (51%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
           G +H  A+T +G+  ++G NQ+GQLG  +   S  P  +Q  EGI + M+A G   T AV
Sbjct: 575 GTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAV 634

Query: 226 TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 381
             +G++Y WG G  G LG  D  D  +P  V   E    ++ +    H  T+
Sbjct: 635 GAEGEVYSWGKGTRGRLGRRD-EDAGLPRPVQLDETHPYMVTSVSCCHGNTL 685



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 23/58 (39%), Positives = 33/58 (56%)
 Frame = +1

Query: 1   RSRRCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 174
           R +   G  +  +ACGD+  +AV   GEV SWG+   G+LG    ED+ LP+ +Q  E
Sbjct: 612 RVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLG-RRDEDAGLPRPVQLDE 668

---

>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 48/136 (35%), Positives = 76/136 (55%), Gaps = 1/136 (0%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAG 204
           +K  ACG +H L  T  G V + G N  GQLGLG TE+      I  F     +K ++AG
Sbjct: 89  VKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAG 148

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 384
           +  +AA+TEDG ++ WG    G +GL + ++  VP++V+   G  +  ++CG+ H+  V+
Sbjct: 149 SNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVT 206

Query: 385 XXGSLYTYXWSKYGQL 432
             G LY +   + G+L
Sbjct: 207 TDGELYVFGEPENGKL 222



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 42/133 (31%), Positives = 66/133 (49%), Gaps = 1/133 (0%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           L+CGD H   VT   ++  +G N  GQLGLG+      P  ++A +   VK+ A G  HT
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD-KMVLVACGWRHTITVSXXG 393
              TE G++Y  G    G LGLGD  +R     +S    + K+  ++ G   +  ++  G
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 394 SLYTYXWSKYGQL 432
            L+ +  +  GQ+
Sbjct: 160 RLFMWGDNSEGQI 172



 Score = 72.8 bits (177), Expect = 3e-13
 Identities = 42/141 (29%), Positives = 73/141 (51%), Gaps = 3/141 (2%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT--TEDSLLPQTIQAFEGISVKM 192
           G  +  ++CG  H   VT  GE+  +G  +NG+LGL      +   PQ +       V  
Sbjct: 189 GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQ 247

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVLVACGWRH 369
           +A G EHT  +TE+  +Y +G G++G LGLG    +   P+ + ++    +  ++CG  H
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306

Query: 370 TITVSXXGSLYTYXWSKYGQL 432
           T  ++  G +YT+   ++G+L
Sbjct: 307 TALITDIGLMYTFGDGRHGKL 327



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 44/117 (37%), Positives = 66/117 (56%), Gaps = 3/117 (2%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAE 210
           Q+ACG  H + +T    V ++G  Q GQLGLGT   ++  P+ I+     ++  I+ G  
Sbjct: 247 QVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGEN 305

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTI 375
           HTA +T+ G +Y +G GR+G LGLG  N  + F+P   S+     + LVACG  H +
Sbjct: 306 HTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMV 362



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGISVK 189
           R   I  ++CG++H   +T  G + ++G  ++G+LGLG     +  +P     F    VK
Sbjct: 293 RDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVK 352

Query: 190 MIAAGAEH 213
           ++A G  H
Sbjct: 353 LVACGGCH 360

---

>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 51/126 (40%), Positives = 69/126 (54%), Gaps = 3/126 (2%)
 Frame = +1

Query: 64  AVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAF-EGISVKMIAAGAEHTAAVTEDGD 240
           A   A  + +WG N  GQLGLG  ED LLPQ +  F +  SV+ I  G  H+A VT+ GD
Sbjct: 10  AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGD 69

Query: 241 IYGWGWGRYGNLGLGDRND--RFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXW 414
           ++  G  + G LGLG   D   F P K  S+ G  +  VACGW  TI ++  G + +   
Sbjct: 70  LFVCGLNKDGQLGLGHTEDIPYFTPCK--SLFGCPIQQVACGWDFTIMLTENGQVLSCGS 127

Query: 415 SKYGQL 432
           + +GQL
Sbjct: 128 NSFGQL 133



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 37/132 (28%), Positives = 67/132 (50%)
 Frame = +1

Query: 13  CRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
           C+   ++++  G  H   VT  G++   G N++GQLGLG TED       ++  G  ++ 
Sbjct: 46  CKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQ 105

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
           +A G + T  +TE+G +   G   +G LG+     R V  +   +  +K+V +A G RH 
Sbjct: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHA 165

Query: 373 ITVSXXGSLYTY 408
           +  +  G ++ +
Sbjct: 166 VAATASGIVFQW 177



 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 48/146 (32%), Positives = 72/146 (49%), Gaps = 8/146 (5%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMI 195
           G  I+Q+ACG    + +T  G+VLS G N  GQLG+       ++PQ I+  +   V  I
Sbjct: 100 GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKE-KVVCI 158

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYG---NLGLGDRNDRFV----PEKVSSVEGDKMVLVA 354
           AAG  H  A T  G ++ WG G       L  G     F     P +V+ +E  K + V 
Sbjct: 159 AAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVL 218

Query: 355 CGWRHTITVSXXGSLYTYXWSKYGQL 432
            G  H+ +++  G +Y +  +K+GQL
Sbjct: 219 AGSDHSASLTDAGEVYVWGSNKHGQL 244



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 41/147 (27%), Positives = 71/147 (48%), Gaps = 15/147 (10%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP-QTIQAF------------EG 177
           +A G  H +A T +G V  WG       GL +    L P QT+  F            E 
Sbjct: 158 IAAGLRHAVAATASGIVFQWGT------GLASCGRRLCPGQTLPLFFTAKEPSRVTGLEN 211

Query: 178 ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS--VEGDKMVLV 351
                + AG++H+A++T+ G++Y WG  ++G L   +     VP+K+ +   + +K+  +
Sbjct: 212 SKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVTAI 270

Query: 352 ACGWRHTITVSXXGSLYTYXWSKYGQL 432
             GW H +  +  G ++T+  + YGQL
Sbjct: 271 WSGWTHLVAQTETGKMFTWGRADYGQL 297



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 47/147 (31%), Positives = 70/147 (47%), Gaps = 20/147 (13%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP--QTIQA--FEGISVKMIAAGAEH 213
           G  H  ++T AGEV  WG N++GQL     E + LP  Q I+A  F+   V  I +G  H
Sbjct: 220 GSDHSASLTDAGEVYVWGSNKHGQLA---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTH 276

Query: 214 TAAVTEDGDIYGWGWGRYGNLGLG---------DRNDRFVP--EKVSSVEGDKMVL---- 348
             A TE G ++ WG   YG LG           ++ D F+P     +S+      L    
Sbjct: 277 LVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGAT 336

Query: 349 -VACGWRHTITVSXXGSLYTYXWSKYG 426
            V+CG  H + +   G  Y++ W+++G
Sbjct: 337 EVSCGSEHNLAI-IGGVCYSWGWNEHG 362



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 39/130 (30%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLG--LGTTE-------DSLLP---------QTIQAF 171
           G +H +A T  G++ +WGR   GQLG  L T E       DS LP          +    
Sbjct: 273 GWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCL 332

Query: 172 EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLV 351
            G +   ++ G+EH  A+   G  Y WGW  +G  G G   + + P+ V ++     +LV
Sbjct: 333 TGATE--VSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLV 389

Query: 352 ACGWRHTITV 381
            CG  H++ +
Sbjct: 390 GCGAGHSLAL 399



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 22/66 (33%), Positives = 37/66 (56%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEH 213
           +++CG  H LA+ + G   SWG N++G  G GT  +   P+ +QA    S  ++  GA H
Sbjct: 337 EVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGH 395

Query: 214 TAAVTE 231
           + A+ +
Sbjct: 396 SLALCQ 401

---

>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 81.6 bits (200), Expect = 7e-16
 Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 4/142 (2%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKM 192
            G   + +ACG  H L ++ +G++ +WG N+ GQ G+G    S     +   +G   +++ 
Sbjct: 775  GGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVG---HSFRIANLHQVDGDWPAIEK 831

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWR 366
            IA G  H+A +  DG ++ +GWG +G LG G RN  ++ VP +V+ +   K+  +ACG  
Sbjct: 832  IACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIACGRA 890

Query: 367  HTITVSXXGSLYTYXWSKYGQL 432
            HT+ ++  G +       YGQ+
Sbjct: 891  HTVVLTDTGRVLVCGSGSYGQM 912



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 43/172 (25%), Positives = 69/172 (40%), Gaps = 38/172 (22%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNG------------QLGLGTTEDSLLP------ 153
            ++ +A    H + +T    V  WGRN                  L  TED   P      
Sbjct: 934  VRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNG 993

Query: 154  --------------------QTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 273
                                + ++ F   ++  +A G  H+A +T +G +Y WG G    
Sbjct: 994  STPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQ 1053

Query: 274  LGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQ 429
            LG G++N+R  P +V    G K V V+ G  HTI  +  GS++ +  + +GQ
Sbjct: 1054 LGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQ 1105



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 27/85 (31%), Positives = 43/85 (50%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
            I  +ACG SH   +T  G + +WG+  + QLG G   + + P  +    G     ++ G 
Sbjct: 1024 IVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGN 1083

Query: 208  EHTAAVTEDGDIYGWGWGRYGNLGL 282
             HT A T+DG ++ WG   +G  G+
Sbjct: 1084 NHTIASTDDGSVFAWGKNDFGQCGV 1108



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 32/97 (32%), Positives = 51/97 (52%), Gaps = 2/97 (2%)
 Frame = +1

Query: 148  LPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSV 327
            LP+ ++ + G   + IA GAEH   ++  G +  WG  R+G  G+G     F    +  V
Sbjct: 767  LPRVLE-YPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVG---HSFRIANLHQV 822

Query: 328  EGDKMVL--VACGWRHTITVSXXGSLYTYXWSKYGQL 432
            +GD   +  +ACG  H+  +   GSL+T+ W  +GQL
Sbjct: 823  DGDWPAIEKIACGQFHSAFICSDGSLWTFGWGVWGQL 859



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAA 201
            I+++ACG  H   +   G + ++G    GQLG G   +S  L+P  +       V  IA 
Sbjct: 829  IEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIAC 887

Query: 202  GAEHTAAVTEDGDIYGWGWGRYGNLGLGD 288
            G  HT  +T+ G +   G G YG +G+ D
Sbjct: 888  GRAHTVVLTDTGRVLVCGSGSYGQMGVDD 916



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 39/170 (22%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
            + Q+ACG +H + +T  G VL  G    GQ+G+      +   T      + V+ IA   
Sbjct: 882  VTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHY 941

Query: 208  EHTAAVTEDGDIYGWGWGRYG------------------------------------NLG 279
             H+  +TED  ++ WG                                         NL 
Sbjct: 942  YHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLN 1001

Query: 280  LG---DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSK 420
            L     R D  + E    ++G+ +V VACG  H+  ++  G+LYT  W K
Sbjct: 1002 LPAEIPREDLGLREVKHFLDGN-IVSVACGLSHSALITSEGTLYT--WGK 1048



 Score = 32.7 bits (73), Expect = 0.38
 Identities = 14/41 (34%), Positives = 25/41 (60%)
 Frame = +1

Query: 19   GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTED 141
            G+    ++ G++H +A T  G V +WG+N  GQ G+ T ++
Sbjct: 1073 GAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKN 1113

---

>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 81.3 bits (199), Expect = 9e-16
 Identities = 41/138 (29%), Positives = 69/138 (50%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  IK +ACGD     +T  G ++++G   NG LG G+  D   P  ++A  G  +  +A
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVA 449

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            GA H  A++ + +++ WG G  G LGLG R     P++V    G +   V CG   ++ 
Sbjct: 450 CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMI 509

Query: 379 VSXXGSLYTYXWSKYGQL 432
           ++  G       +++ +L
Sbjct: 510 LTVPGQALACGSNRFNKL 527



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 42/152 (27%), Positives = 72/152 (47%), Gaps = 14/152 (9%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  + Q+ACG SH LA++   E+ +WGR  +G+LGLGT E    PQ +    G   + + 
Sbjct: 442 GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVV 501

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLG--DRNDRFVPEK------------VSSVEGD 336
            G + +  +T  G     G  R+  LGL      +  VP +             + ++ +
Sbjct: 502 CGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQE 561

Query: 337 KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
            ++ +  G  H+  V+  G  YT+  +++GQL
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQL 593



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 33/83 (39%), Positives = 47/83 (56%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
           G +H  AVT +G+  ++G NQ+GQLG  T   S  P  +Q  EGI + M+A G   T A+
Sbjct: 569 GTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAI 628

Query: 226 TEDGDIYGWGWGRYGNLGLGDRN 294
             + ++Y WG G  G LG  D +
Sbjct: 629 GAESEVYSWGKGARGRLGRRDED 651



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 44/154 (28%), Positives = 74/154 (48%), Gaps = 16/154 (10%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGL---GTTEDSLLPQTIQAFEGISVK 189
           G   +++ CG    + +T+ G+ L+ G N+  +LGL      E+ +  Q ++  E +S  
Sbjct: 494 GQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVE--EALSFT 551

Query: 190 MIAA-------------GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 330
           ++ +             G  H+AAVT  GD Y +G  ++G LG   R     P KV  +E
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE 611

Query: 331 GDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
           G KM +VACG   T+ +     +Y++     G+L
Sbjct: 612 GIKMAMVACGDAFTVAIGAESEVYSWGKGARGRL 645



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 20/52 (38%), Positives = 30/52 (57%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 174
           G  +  +ACGD+  +A+    EV SWG+   G+LG    ED+ LP+ +Q  E
Sbjct: 612 GIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLDE 662

---

>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 1/123 (0%)
 Frame = +1

Query: 67  VTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAF-EGISVKMIAAGAEHTAAVTEDGDI 243
           V+ A  + +WG N  GQLGLG  ED  LPQ +  F +   +K +  G  H+A VT+ GD+
Sbjct: 11  VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDL 70

Query: 244 YGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKY 423
           +  G  + G LGLG   +         + G  +  VACGW  TI ++  G + +   + +
Sbjct: 71  FVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAF 130

Query: 424 GQL 432
           GQL
Sbjct: 131 GQL 133



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 40/132 (30%), Positives = 65/132 (49%)
 Frame = +1

Query: 13  CRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
           C+   IK +  G  H   VT  G++   G N++GQLGLG TE+ L     +   G  ++ 
Sbjct: 46  CQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQ 105

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
           +A G + T  +TE G +   G   +G LG+     + V  +      +K+V VA G RH 
Sbjct: 106 VACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAAGLRHA 165

Query: 373 ITVSXXGSLYTY 408
           +  +  GS++ +
Sbjct: 166 LATTATGSVFQW 177



 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 17/157 (10%)
 Frame = +1

Query: 13  CRGSXIKQLACGDSHCLAVTMAGEVLSWGRN-----------QNGQLGLGTTEDSLLPQT 159
           C    +  +A G  H LA T  G V  WG             QN  L L   E    P  
Sbjct: 150 CLREKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKE----PSR 205

Query: 160 IQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV----PEKVSS- 324
           +   E  +     AG++H+A++T+ G++Y WG  ++G L       R V    P+++ + 
Sbjct: 206 VTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA-----SRAVFLPLPQRIEAH 260

Query: 325 -VEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
             + +K+  V  GW H +  +  G ++T+  + YGQL
Sbjct: 261 YFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQL 297



 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 31/80 (38%), Positives = 42/80 (52%), Gaps = 2/80 (2%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA--FEGISVKMIAAGAEHTA 219
           G  H  ++T  GE+  WGRN++GQL         LPQ I+A  F+   V  + +G  H  
Sbjct: 220 GSDHSASLTDTGELYVWGRNKHGQLA-SRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLV 278

Query: 220 AVTEDGDIYGWGWGRYGNLG 279
           A TE G ++ WG   YG LG
Sbjct: 279 AKTETGKVFTWGRADYGQLG 298



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAF--EGISVKMIAAGA 207
           +++CG  H LAV +  +  SWG N++G  G GT  +   P  +QA       + ++  GA
Sbjct: 337 EISCGSEHNLAV-IRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGA 395

Query: 208 EHTAAVTE 231
            H+ AV +
Sbjct: 396 GHSLAVCQ 403

---

>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 39/143 (27%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
 Frame = +1

Query: 10  RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGIS 183
           + +G  I Q++CGD   + VT  G++ ++G +  G +G+      + L P  +  F    
Sbjct: 422 KLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNP 481

Query: 184 VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 363
           V+ ++ G  H   +T + ++Y WG G YG LGL    D + P+KV   +   +V V CG 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGC 541

Query: 364 RHTITVSXXGSLYTYXWSKYGQL 432
             T  ++  G +     +++ +L
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKL 564



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 13/148 (8%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           ++Q++CGD+H + +T   EV SWG  + G+LGL + ED   PQ +   + + +  +  G 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGC 541

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK-------------VSSVEGDKMVL 348
           + T  +T+ G +   G   +  LGL       +  +                +   K+  
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           +A G  HT  +   G L T+  +K GQL
Sbjct: 602 IAPGKTHTAAIDERGRLLTFGCNKCGQL 629



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
 Frame = +1

Query: 151 PQTIQAFE-GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPE 312
           PQ +   + G S + + AG  H A VT + ++Y W     G   +G LG GD+     P+
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418

Query: 313 KVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYG 426
            V  ++G  +  V+CG   T+ V+  G LY +    YG
Sbjct: 419 HVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYG 456



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 39/149 (26%), Positives = 65/149 (43%), Gaps = 14/149 (9%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL--------PQTI-----QA 168
           I  + CG      +T +G+VL+ G N+  +LGL      ++        P T      + 
Sbjct: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593

Query: 169 FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 348
                ++ IA G  HTAA+ E G +  +G  + G LG+G+   R     +    G K V+
Sbjct: 594 LSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVI 653

Query: 349 -VACGWRHTITVSXXGSLYTYXWSKYGQL 432
            V+CG   TI  +    ++ +     G+L
Sbjct: 654 RVSCGDEFTIAATDDNHIFAWGNGGNGRL 682



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 1/86 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAG 204
           I+ +A G +H  A+   G +L++G N+ GQLG+G  +  L    +     G  V  ++ G
Sbjct: 599 IRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCG 658

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGL 282
            E T A T+D  I+ WG G  G L +
Sbjct: 659 DEFTIAATDDNHIFAWGNGGNGRLAM 684



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 13/40 (32%), Positives = 22/40 (55%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 138
           G  + +++CGD   +A T    + +WG   NG+L +  TE
Sbjct: 649 GKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688

---

>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 38/143 (26%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
 Frame = +1

Query: 10  RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGIS 183
           + +G  I Q++CGD   + VT  G++ ++G +  G +G+      + L P  +  F    
Sbjct: 422 KLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNP 481

Query: 184 VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 363
           V+ ++ G  H   +T + ++Y WG G YG LGL    D + P++V   +   +V V CG 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGC 541

Query: 364 RHTITVSXXGSLYTYXWSKYGQL 432
             T  ++  G +     +++ +L
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKL 564



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 13/148 (8%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           ++Q++CGD+H + +T   EV SWG  + G+LGL + ED   PQ +   + + +  +  G 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGC 541

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK-------------VSSVEGDKMVL 348
           + T  +T+ G +   G   +  LGL       +  +                +   K+  
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           +A G  HT  +   G L T+  +K GQL
Sbjct: 602 IAPGKTHTAAIDERGRLLTFGCNKCGQL 629



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
 Frame = +1

Query: 151 PQTIQAFE-GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPE 312
           PQ +   + G S + + AG  H A VT + ++Y W     G   +G LG GD+     P+
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418

Query: 313 KVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYG 426
            V  ++G  +  V+CG   T+ V+  G LY +    YG
Sbjct: 419 HVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYG 456



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 39/149 (26%), Positives = 65/149 (43%), Gaps = 14/149 (9%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL--------PQTI-----QA 168
           I  + CG      +T +G+VL+ G N+  +LGL      ++        P T      + 
Sbjct: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593

Query: 169 FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 348
                ++ IA G  HTAA+ E G +  +G  + G LG+G+   R     +    G K V+
Sbjct: 594 LSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVI 653

Query: 349 -VACGWRHTITVSXXGSLYTYXWSKYGQL 432
            V+CG   TI  +    ++ +     G+L
Sbjct: 654 RVSCGDEFTIAATDDNHIFAWGNGGNGRL 682



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 1/86 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAG 204
           I+ +A G +H  A+   G +L++G N+ GQLG+G  +  L    +     G  V  ++ G
Sbjct: 599 IRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCG 658

Query: 205 AEHTAAVTEDGDIYGWGWGRYGNLGL 282
            E T A T+D  I+ WG G  G L +
Sbjct: 659 DEFTIAATDDNHIFAWGNGGNGRLAM 684



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 13/40 (32%), Positives = 22/40 (55%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 138
           G  + +++CGD   +A T    + +WG   NG+L +  TE
Sbjct: 649 GKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688

---

>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 75.5 bits (184), Expect = 5e-14
 Identities = 37/114 (32%), Positives = 59/114 (51%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  IK ++CGD     +T  G ++++G   NG LG G   D   P+ ++A  G  +  ++
Sbjct: 397 GVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVS 456

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
            GA H  AVT + +++ WG G  G LGL  ++    P++VS     +   V CG
Sbjct: 457 CGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCG 510



 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 14/152 (9%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 198
           G  + Q++CG SH LAVT   EV SWGR  NG+LGL T +    PQ +        + + 
Sbjct: 449 GYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVL 508

Query: 199 AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE--------------GD 336
            G + +  ++    I   G  R+  LGL   +    P     VE               +
Sbjct: 509 CGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTE 568

Query: 337 KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
           K+V +  G  H++ V+  G  +T+  +++GQL
Sbjct: 569 KIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQL 600



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 38/112 (33%), Positives = 58/112 (51%), Gaps = 2/112 (1%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
           G +H +AVT  G+  ++G NQ+GQLG      S +P  +   +GI+  M A G   T A+
Sbjct: 576 GTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGIT--MAACGDAFTLAI 633

Query: 226 TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL--VACGWRHTI 375
             +G++Y WG G  G LG  +  D  +P+ V   E     +  VAC   +T+
Sbjct: 634 GAEGEVYTWGKGARGRLGRKE-EDFGIPKPVQLDESHAFTVTSVACCHGNTL 684



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 41/148 (27%), Positives = 71/148 (47%), Gaps = 14/148 (9%)
 Frame = +1

Query: 31  KQLACGDSHCLAVTMAGEVLSWGRNQNGQLGL----GTTEDSLLPQT--IQAFEGIS--- 183
           +++ CG    + ++   ++L+ G N+  +LGL    GT E S   Q   +  F+ +    
Sbjct: 505 QRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAP 564

Query: 184 -----VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 348
                +  I  G  H+ AVTE G  + +G  ++G LG   R    VP +VS ++G  + +
Sbjct: 565 LNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQG--ITM 622

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
            ACG   T+ +   G +YT+     G+L
Sbjct: 623 AACGDAFTLAIGAEGEVYTWGKGARGRL 650



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 21/62 (33%), Positives = 32/62 (51%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           I   ACGD+  LA+   GEV +WG+   G+LG    ED  +P+ +Q  E  +  + +   
Sbjct: 620 ITMAACGDAFTLAIGAEGEVYTWGKGARGRLG-RKEEDFGIPKPVQLDESHAFTVTSVAC 678

Query: 208 EH 213
            H
Sbjct: 679 CH 680

---

>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 39/143 (27%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
 Frame = +1

Query: 10  RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGIS 183
           + +G  +++++CG    + +T  G++ S+G +  G LG+  +  S  L P  +  F    
Sbjct: 404 KLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEP 463

Query: 184 VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 363
           V  ++ G  H  A+T    +Y WG G YG LGL   +D + P+KV    G  +V V CG 
Sbjct: 464 VDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGS 523

Query: 364 RHTITVSXXGSLYTYXWSKYGQL 432
             +  ++  G +     +++ +L
Sbjct: 524 DGSFLLTLTGKVLACGLNEHNKL 546



 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 42/148 (28%), Positives = 72/148 (48%), Gaps = 13/148 (8%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           + Q++CGDSH +A+T +  V SWG  + G+LGL + +D   PQ ++   G+ +  +  G+
Sbjct: 464 VDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGS 523

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGD------RNDRF--VPEKVS-----SVEGDKMVL 348
           + +  +T  G +   G   +  LGL         ++ F  VP   S      +   K+  
Sbjct: 524 DGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRS 583

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           ++ G  HT  +   G L T+  +K GQL
Sbjct: 584 ISPGRTHTAAIDERGRLLTFGSNKCGQL 611



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 39/130 (30%), Positives = 60/130 (46%), Gaps = 6/130 (4%)
 Frame = +1

Query: 61  LAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAGAEHTAAVTEDG 237
           +  + + EV  WG       G  TT     PQ +  F+G    + + AG  H A VT + 
Sbjct: 323 VVTSRSSEVYVWG-------GGKTT-----PQKLDVFKGGWRARQVCAGDAHFAVVTVEK 370

Query: 238 DIYGW-----GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
           ++Y W     G   +G LG GDR     P+ V  ++G  +  V+CG   T+ ++  G LY
Sbjct: 371 ELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLY 430

Query: 403 TYXWSKYGQL 432
           ++    YG L
Sbjct: 431 SFGSDYYGCL 440



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 39/155 (25%), Positives = 68/155 (43%), Gaps = 16/155 (10%)
 Frame = +1

Query: 16  RGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI----- 180
           RG  I  + CG      +T+ G+VL+ G N++ +LGL      ++    +AF+ +     
Sbjct: 512 RGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINH--EAFQEVPYTTS 569

Query: 181 ----------SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 330
                      ++ I+ G  HTAA+ E G +  +G  + G LG+GD         +    
Sbjct: 570 LTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPL 629

Query: 331 GDKMVL-VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           G K V+ V+CG   T   +    ++ +     G+L
Sbjct: 630 GGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRL 664



 Score = 32.3 bits (72), Expect = 0.50
 Identities = 12/40 (30%), Positives = 20/40 (50%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 138
           G  + +++CGD    A T    + +WG   NG+L +   E
Sbjct: 631 GKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRLAMTPNE 670

---

>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 46/147 (31%), Positives = 74/147 (50%), Gaps = 6/147 (4%)
 Frame = +1

Query: 10  RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQT-----IQAFE 174
           R + + + Q++CG +H L +T    V S G N  GQ G    E+ +  ++     +Q F+
Sbjct: 170 RPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD 229

Query: 175 GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV-SSVEGDKMVLV 351
           G  V  +A G +H+  +T+ G++Y  GWG  G  GLG  N    P K+   + G  ++ V
Sbjct: 230 G-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288

Query: 352 ACGWRHTITVSXXGSLYTYXWSKYGQL 432
           A      + VS  G L+ +  S+Y QL
Sbjct: 289 ATYGDCCLAVSADGGLFGWGNSEYLQL 315



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 42/128 (32%), Positives = 64/128 (50%), Gaps = 9/128 (7%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT-EDSLLPQTI--------QAFEGI 180
           ++Q ACG + C  +   G V  WG    G LG G    +S +P+ I        +    I
Sbjct: 338 VRQAACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEI 394

Query: 181 SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
            V  I  G  H AA+T  G+++ WG    G LG+G   D++ P +V ++ G+  V VACG
Sbjct: 395 QVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEP-VDVACG 452

Query: 361 WRHTITVS 384
             H +T++
Sbjct: 453 VDHMVTLA 460



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 23/68 (33%), Positives = 35/68 (51%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           + ++ CG SH  A+T  GE+  WG+N  G LG+G  ED   P  +    G  V  +A G 
Sbjct: 396 VSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGV 453

Query: 208 EHTAAVTE 231
           +H   + +
Sbjct: 454 DHMVTLAK 461



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 36/141 (25%), Positives = 57/141 (40%), Gaps = 7/141 (4%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI-SVKMI 195
           G  + Q+A     CLAV+  G +  WG ++  QL   T    +       F G+  V+  
Sbjct: 282 GVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 341

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYG---NLGLGDRNDRFVPEKVSSVEGDKMVLVA---C 357
           A G    A +  +G ++ WG+G  G   NL      +   P      E +  + V+   C
Sbjct: 342 ACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 401

Query: 358 GWRHTITVSXXGSLYTYXWSK 420
           G  H   ++  G L+   W K
Sbjct: 402 GLSHFAALTNKGELFV--WGK 420

---

>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 6/147 (4%)
 Frame = +1

Query: 10  RCRGSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQT-----IQAFE 174
           R + + + Q++CG +H L +T    V S G N +GQ G    ED +  ++     +Q F+
Sbjct: 167 RPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFD 226

Query: 175 GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV-SSVEGDKMVLV 351
           G  V  +  G +H+  +T+ G++Y  GWG  G  GLG  N    P K+   + G  +V V
Sbjct: 227 G-QVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQV 285

Query: 352 ACGWRHTITVSXXGSLYTYXWSKYGQL 432
           A      + +S  G ++ +  S+Y QL
Sbjct: 286 ATYGDCCLALSADGGVFGWGNSEYLQL 312



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 42/128 (32%), Positives = 64/128 (50%), Gaps = 9/128 (7%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLG-----TTEDSLLPQTIQAFEG----I 180
           +KQ+ACG + C  +   G V  WG    G LG G     T    ++P T+         +
Sbjct: 335 VKQVACGGTGCAVLNAEGHVFVWGY---GILGKGPKLLETAIPEMIPPTLFGLTEFNPEV 391

Query: 181 SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 360
            V  I  G  H AA+T  G+++ WG    G LG+G   D++ P +V ++ G+  V VACG
Sbjct: 392 QVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEP-VDVACG 449

Query: 361 WRHTITVS 384
             H +T++
Sbjct: 450 VDHMVTLA 457



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 40/144 (27%), Positives = 62/144 (43%), Gaps = 10/144 (6%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI-SVKMI 195
           G  + Q+A     CLA++  G V  WG ++  QL   T    +       F G+  VK +
Sbjct: 279 GVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQV 338

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKV-----SSVEGDKMVLVA- 354
           A G    A +  +G ++ WG   YG LG G +  +  +PE +        E +  V V+ 
Sbjct: 339 ACGGTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQ 395

Query: 355 --CGWRHTITVSXXGSLYTYXWSK 420
             CG  H   ++  G L+   W K
Sbjct: 396 IRCGLSHFAALTNKGELFV--WGK 417



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 24/68 (35%), Positives = 35/68 (51%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           + Q+ CG SH  A+T  GE+  WG+N  G LG+G  ED   P  +    G  V  +A G 
Sbjct: 393 VSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGV 450

Query: 208 EHTAAVTE 231
           +H   + +
Sbjct: 451 DHMVTLAK 458

---

>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 22/155 (14%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGL----GTTEDS---LLPQTIQAFEGISV 186
           IK +A GD HC A+  +  V +WG NQ GQ  L    G  ED    + P  I       +
Sbjct: 253 IKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGI 312

Query: 187 KMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE------------ 330
           K IAAG  HT A+TEDG +Y   WGRY    +G   D+ +P+    +             
Sbjct: 313 KEIAAGEHHTLALTEDGQVY--AWGRYDMKEIGIPKDK-LPKSTFKINTGTHGSFSFLQN 369

Query: 331 --GDKMVLVACGWRHTITVSXXGSLYTYXWSK-YG 426
               K+  +  G  H+  V+  G +Y + +++ YG
Sbjct: 370 LFAVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYG 404



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 38/133 (28%), Positives = 69/133 (51%), Gaps = 16/133 (12%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG---------- 177
           IK++A G+ H LA+T  G+V +WGR    ++G+   +D L   T +   G          
Sbjct: 312 IKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGI--PKDKLPKSTFKINTGTHGSFSFLQN 369

Query: 178 ---ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKV--SSVEGDK 339
              + +K I  G+ H+ AVTEDG +Y WG+      GLG   +D   P ++  ++ + + 
Sbjct: 370 LFAVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNED 429

Query: 340 MVLVACGWRHTIT 378
           ++L+  G + +++
Sbjct: 430 ILLIGAGGQFSVS 442



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 7/94 (7%)
 Frame = +1

Query: 163 QAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL----GDRNDRFV---PEKVS 321
           Q F   ++K IA+G  H  A+    ++Y WG  +YG   L    G+  D  V   P  + 
Sbjct: 246 QQFGLYNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIP 305

Query: 322 SVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKY 423
            +    +  +A G  HT+ ++  G +  Y W +Y
Sbjct: 306 ELSHKGIKEIAAGEHHTLALTEDGQV--YAWGRY 337



 Score = 35.4 bits (80), Expect = 0.059
 Identities = 30/126 (23%), Positives = 43/126 (34%), Gaps = 27/126 (21%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT---------------------- 132
           G+ I   A G  H LA+     + SWG N +  LG  T                      
Sbjct: 64  GTKIVDFAVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDD 123

Query: 133 -----TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRND 297
                 E    P  ++      +  +AA    +AA+  +GD+Y WG  R     LG   D
Sbjct: 124 EDGDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLGFLRD 183

Query: 298 RFVPEK 315
               +K
Sbjct: 184 EIKLQK 189

---

>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 42/147 (28%), Positives = 71/147 (48%), Gaps = 16/147 (10%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLG-TTEDSLL---PQTIQAFEGISVKMI 195
           +K +A G++HC A+T   +++SWG NQ GQ G+    ED  L   P+ +   + + ++ I
Sbjct: 276 VKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSI 335

Query: 196 AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN------------DRFVPEKVSSVEGDK 339
           AAG  H+  +++DGD+Y  G      +G+   N             R VP         K
Sbjct: 336 AAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPK 395

Query: 340 MVLVACGWRHTITVSXXGSLYTYXWSK 420
              VA G  H++ V+  G  Y++ + +
Sbjct: 396 FKSVAAGSHHSVAVAQNGIAYSWGFGE 422



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 36/134 (26%), Positives = 69/134 (51%), Gaps = 17/134 (12%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS-------- 183
           I+ +A G+ H L ++  G++ S GR    ++G+   +D+L   T +   G +        
Sbjct: 332 IRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGI--PKDNLPEYTYKDVHGKARAVPLPTK 389

Query: 184 ------VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKV--SSVEGD 336
                  K +AAG+ H+ AV ++G  Y WG+G    +GLG   +D  VP ++  ++ +  
Sbjct: 390 LNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDH 449

Query: 337 KMVLVACGWRHTIT 378
            ++LV CG + +++
Sbjct: 450 NIILVGCGGQFSVS 463



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 11/148 (7%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL----LPQTIQAFEGISV 186
           G  + QLA  D+   A+   GEV +WG  +  +  LG  +D +     P  +  F   ++
Sbjct: 164 GHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNI 223

Query: 187 KMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD-------KMV 345
             +A G +H   + E+G ++ WG G+   LG      R V E+      D        + 
Sbjct: 224 VQLAPGKDHILFLDEEGMVFAWGNGQQNQLG------RKVMERFRLKTLDPRPFGLRHVK 277

Query: 346 LVACGWRHTITVSXXGSLYTYXWSKYGQ 429
            +A G  H   ++    L ++  +++GQ
Sbjct: 278 YIASGENHCFALTKDNKLVSWGLNQFGQ 305



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 45/168 (26%), Positives = 65/168 (38%), Gaps = 33/168 (19%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT-----------------EDSLL-- 150
           I   A G  H LA+     V SWG N  G LG  T+                 ED  L  
Sbjct: 86  IISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNE 145

Query: 151 ----PQTI--QAF----EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR 300
               P  I  ++F    EG  V  +AA    + A+  +G++Y WG  R     LG   D+
Sbjct: 146 LESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDK 205

Query: 301 F----VPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
                 P KV +     +V +A G  H + +   G ++ +   +  QL
Sbjct: 206 IKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQL 253



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 5/90 (5%)
 Frame = +1

Query: 82  EVLSWGRNQNGQLGLGT---TEDSLLPQTIQAFEGISVKMI--AAGAEHTAAVTEDGDIY 246
           ++  WG     +LGLG     ++   P+          K+I  A G  HT A+ E+ +++
Sbjct: 47  DIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPRDEAKIISFAVGGMHTLALDEESNVW 106

Query: 247 GWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 336
            WG    G LG    N +   E++  ++ D
Sbjct: 107 SWGCNDVGALGRDTSNAK---EQLKDMDAD 133

---

>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 40/134 (29%), Positives = 68/134 (50%), Gaps = 2/134 (1%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           ++ G  H L +T +G++ S+G N  G LG  T+ED    +            I+AG  H+
Sbjct: 79  ISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHS 138

Query: 217 AAVTEDGDIYGWGWGR--YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXX 390
           A + EDG ++ WG  R  +GN+GL    ++  P  +  +EG     +A G  H + ++  
Sbjct: 139 ACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTP--IDLMEGTVCCSIASGADHLVILTTA 196

Query: 391 GSLYTYXWSKYGQL 432
           G ++T   ++ GQL
Sbjct: 197 GKVFTVGCAEQGQL 210



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           I+ +A G  H + +T   +    GR + G+LGLG  +D +   TI       +  +  G 
Sbjct: 295 IRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGE 354

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS--VEGDKMVLVACGWRHTI 375
             + AVT DG +Y WG G    LG+GD +D   P  V S   +G  M+L + G +H I
Sbjct: 355 VCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAI 412



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 25/81 (30%), Positives = 37/81 (45%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHT 216
           ++ GDSH   +   G V +WG  ++    +G T D      I   EG     IA+GA+H 
Sbjct: 131 ISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHL 190

Query: 217 AAVTEDGDIYGWGWGRYGNLG 279
             +T  G ++  G    G LG
Sbjct: 191 VILTTAGKVFTVGCAEQGQLG 211



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 1/114 (0%)
 Frame = +1

Query: 70  TMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM-IAAGAEHTAAVTEDGDIY 246
           T+ G VL  G    GQLGLG  ED L  + +    GI   + I+AG  H   +T+ GDIY
Sbjct: 39  TVLGNVLVCGNGDVGQLGLG--EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIY 96

Query: 247 GWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTY 408
            +G    G LG     D    +        K + ++ G  H+  +   G ++ +
Sbjct: 97  SFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAW 150



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 31/85 (36%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
 Frame = +1

Query: 184 VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE--GDKMVLVAC 357
           ++ IA G  HT  +T D      G   YG LGLGD  D  V EK + V+   +K+V V C
Sbjct: 295 IRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKD--VVEKPTIVKKLTEKIVSVGC 352

Query: 358 GWRHTITVSXXGSLYTYXWSKYGQL 432
           G   +  V+  G LY++      QL
Sbjct: 353 GEVCSYAVTIDGKLYSWGSGVNNQL 377

---

>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 45/140 (32%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAA 201
           + Q   G  H + ++ +G+V S+G N  G LG  T+ +   ++P  ++  E   V  ++A
Sbjct: 69  VVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSA 126

Query: 202 GAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
           G  HTAA+TEDG ++ WG  R  N  +G         VP +V       +V VA G  H 
Sbjct: 127 GDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DAPVVKVASGNDHL 184

Query: 373 ITVSXXGSLYTYXWSKYGQL 432
           + ++  G LYT    + GQL
Sbjct: 185 VMLTNDGDLYTLGCGEQGQL 204



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 3/113 (2%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAA 222
           G  H + +   G+  S GR + G+LGLG   E+  +P  I     +S   +A GA    A
Sbjct: 302 GQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVS--SVACGASVGYA 359

Query: 223 VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVS--SVEGDKMVLVACGWRHTI 375
           V++DG ++ WG G    LG G   D + P +++   +E   ++ V+ G +HT+
Sbjct: 360 VSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTV 412



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 42/148 (28%), Positives = 66/148 (44%), Gaps = 4/148 (2%)
 Frame = +1

Query: 1   RSRRCRGSXIKQLA-CGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG 177
           +SR  RG    Q A CG     A++  G V  +G +   QLG   T    +PQ + +F+ 
Sbjct: 232 KSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKN 291

Query: 178 ISVKMI--AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVL 348
            +   +  + G  HT  +  +G  Y  G   YG LGLG+   ++ +P  +S +    +  
Sbjct: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSS 349

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           VACG      VS  G ++ +      QL
Sbjct: 350 VACGASVGYAVSKDGRVFAWGMGTNYQL 377



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 38/156 (24%), Positives = 71/156 (45%), Gaps = 21/156 (13%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLG--------------LGTTEDSLLPQTI- 162
           + ++A G+ H + +T  G++ + G  + GQLG              LG     L+P+ + 
Sbjct: 174 VVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRL---LVPRCVL 230

Query: 163 ---QAFEG-ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 330
              +   G +  +    GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +
Sbjct: 231 LKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFK 290

Query: 331 GD--KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
                 V  + G  HT+ +   G  Y+   ++YG+L
Sbjct: 291 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 326



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 4/123 (3%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKMIAAGAEHTAAV 225
           SH    T  G VL+ G+   GQLGLG   +S+L +   A   +   V    AG  HT  +
Sbjct: 26  SHRSHNTEPGLVLTLGQGDVGQLGLG---ESVLERKKPALVPLLQDVVQAEAGGMHTVCL 82

Query: 226 TEDGDIYGWGWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSL 399
           ++ G +Y +G    G LG          VP KV   E  K+V V+ G  HT  ++  G +
Sbjct: 83  SQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTEDGRV 140

Query: 400 YTY 408
           + +
Sbjct: 141 FLW 143



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 25/71 (35%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP--QTIQAFEGISVKMIAA 201
           +  +ACG S   AV+  G V +WG   N QLG G  ED+  P   T +  E   V  +++
Sbjct: 347 VSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSS 406

Query: 202 GAEHTAAVTED 234
           G +HT  + +D
Sbjct: 407 GGQHTVLLVKD 417

---

>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 45/140 (32%), Positives = 69/140 (49%), Gaps = 5/140 (3%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAA 201
           + Q   G  H + +  +G+V S+G N  G LG  T+ +   ++P  ++  E   V  ++A
Sbjct: 69  VVQAEAGGMHTVCLNQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSA 126

Query: 202 GAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
           G  HTAA+TEDG ++ WG  R  N  +G         VP +V       +V VA G  H 
Sbjct: 127 GDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DMPVVKVASGNDHL 184

Query: 373 ITVSXXGSLYTYXWSKYGQL 432
           + ++  G LYT    + GQL
Sbjct: 185 VMLTTDGDLYTLGCGEQGQL 204



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 3/113 (2%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAA 222
           G  H + +   G+  S GR + G+LGLG   E+  +P  I     +S   +A GA    A
Sbjct: 302 GQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVS--SVACGASVGYA 359

Query: 223 VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVS--SVEGDKMVLVACGWRHTI 375
           V++DG ++ WG G    LG G   D + P +++   +E   ++ V+ G +HT+
Sbjct: 360 VSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTV 412



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 42/148 (28%), Positives = 66/148 (44%), Gaps = 4/148 (2%)
 Frame = +1

Query: 1   RSRRCRGSXIKQLA-CGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG 177
           +SR  RG    Q A CG     A++  G V  +G +   QLG   T    +PQ + +F+ 
Sbjct: 232 KSRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKN 291

Query: 178 ISVKMI--AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVL 348
            +   +  + G  HT  +  +G  Y  G   YG LGLG+   ++ +P  +S +    +  
Sbjct: 292 STKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSS 349

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           VACG      VS  G ++ +      QL
Sbjct: 350 VACGASVGYAVSKDGRVFAWGMGTNYQL 377



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 38/153 (24%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT-----------EDSLLPQTI---- 162
           + ++A G+ H + +T  G++ + G  + GQLG               E  L+P+ +    
Sbjct: 174 VVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVLLKS 233

Query: 163 QAFEG-ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD- 336
           +   G +  +    GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +   
Sbjct: 234 RGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNST 293

Query: 337 -KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
              V  + G  HTI +   G  Y+   ++YG+L
Sbjct: 294 KSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRL 326



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 4/123 (3%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKMIAAGAEHTAAV 225
           SH    T  G VL+ G+   GQLGLG   +S+L +   A   +   V    AG  HT  +
Sbjct: 26  SHRSHKTEPGLVLTLGQGDVGQLGLG---ESVLERKKPALVPLLQDVVQAEAGGMHTVCL 82

Query: 226 TEDGDIYGWGWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSL 399
            + G +Y +G    G LG          VP KV   E  K+V V+ G  HT  ++  G +
Sbjct: 83  NQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTEDGRV 140

Query: 400 YTY 408
           + +
Sbjct: 141 FLW 143



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 25/71 (35%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP--QTIQAFEGISVKMIAA 201
           +  +ACG S   AV+  G V +WG   N QLG G  ED+  P   T +  E   V  +++
Sbjct: 347 VSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSS 406

Query: 202 GAEHTAAVTED 234
           G +HT  + +D
Sbjct: 407 GGQHTVLLVKD 417

---

>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 41/147 (27%), Positives = 60/147 (40%), Gaps = 20/147 (13%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS-----LLPQTIQAFEGISVKM 192
           I  +  G  H  A+   G V +WG N   Q G+   ++        P  + A EG +VK 
Sbjct: 281 IISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKS 340

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG------------- 333
           I  G  HT A+ EDG +  WG      LG+    D  +PE V   E              
Sbjct: 341 ITGGEHHTLALLEDGRVLAWGRDDRHQLGI---PDNALPETVVKDEKGNNYYLSTPTIIP 397

Query: 334 --DKMVLVACGWRHTITVSXXGSLYTY 408
               ++ V CG  H + V+  G +Y++
Sbjct: 398 GLTNVIQVVCGTHHNLAVTSDGKVYSW 424



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 39/118 (33%), Positives = 54/118 (45%), Gaps = 16/118 (13%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG------- 177
           G  +K +  G+ H LA+   G VL+WGR+   QLG+    D+ LP+T+   E        
Sbjct: 335 GYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGI---PDNALPETVVKDEKGNNYYLS 391

Query: 178 --------ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN-DRFVPEKVSS 324
                    +V  +  G  H  AVT DG +Y WG      +G GD + D  VP  V S
Sbjct: 392 TPTIIPGLTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRS 449



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 9/136 (6%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE----DSLLPQTIQAFEGISVKMI 195
           I QLA G  H +A+T  G+V +WG  Q  QLG    E      L PQ +     ISV   
Sbjct: 228 ICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISV--- 284

Query: 196 AAGAEHTAAVTEDGDIYGWGWG--RYGNLGLGDRNDRFV---PEKVSSVEGDKMVLVACG 360
            AG+ H+ A+   G +Y WG    R   + + D  +  V   P  V ++EG  +  +  G
Sbjct: 285 GAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGG 344

Query: 361 WRHTITVSXXGSLYTY 408
             HT+ +   G +  +
Sbjct: 345 EHHTLALLEDGRVLAW 360



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 14/149 (9%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGT----------TEDSLLPQTIQAFEG 177
           +  LA G  H  A++  G V +WG N +  LG  T           ++ LL  T    EG
Sbjct: 110 VVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEG 169

Query: 178 ----ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 345
               + V  +      TAA+T++G  + WG  R  +  LG  + +    + + +   ++ 
Sbjct: 170 ALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEIC 229

Query: 346 LVACGWRHTITVSXXGSLYTYXWSKYGQL 432
            +A G  H I ++  G +YT+   +  QL
Sbjct: 230 QLATGTDHIIALTTTGKVYTWGNGQQFQL 258



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 20/62 (32%), Positives = 37/62 (59%), Gaps = 3/62 (4%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI---QAFEGISVKMIAAG 204
           Q+ CG  H LAVT  G+V SWG  +N ++G G  ++ +   T+   +A + +++++  AG
Sbjct: 404 QVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEVAIRVAGAG 463

Query: 205 AE 210
            +
Sbjct: 464 GQ 465



 Score = 36.2 bits (82), Expect = 0.035
 Identities = 33/126 (26%), Positives = 55/126 (43%), Gaps = 18/126 (14%)
 Frame = +1

Query: 85  VLSWGRNQNGQLGLGTTEDSLLPQT----IQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 252
           V  +G     +LG+G  E  ++ +     I + + + V  +A G  H+AA++ DG +Y W
Sbjct: 73  VYVFGSGSMNELGMGEEEMDVVYRPRLNPILSTDKVGVVDLAVGGMHSAALSHDGRVYTW 132

Query: 253 GWGRYGNLGL---------GDRNDRFVPEKV-SSVEGD----KMVLVACGWRHTITVSXX 390
           G      LG          GD+ D  + E   S VEG     ++  V C    T  ++  
Sbjct: 133 GVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITDN 192

Query: 391 GSLYTY 408
           G  +T+
Sbjct: 193 GCCFTW 198

---

>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 44/140 (31%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAA 201
           + Q   G  H + ++ +G+V S+G N  G LG  T+ +   ++P  ++  E   V  ++A
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSA 126

Query: 202 GAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
           G  HTAA+T+DG ++ WG  R  N  +G         VP +V       +V VA G  H 
Sbjct: 127 GDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHL 184

Query: 373 ITVSXXGSLYTYXWSKYGQL 432
           + ++  G LYT    + GQL
Sbjct: 185 VMLTADGDLYTLGCGEQGQL 204



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 3/113 (2%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAA 222
           G  H + +   G+  S GR + G+LGLG   E+  +P  I     +S   +A GA    A
Sbjct: 302 GQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASVGYA 359

Query: 223 VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV--SSVEGDKMVLVACGWRHTI 375
           VT+DG ++ WG G    LG G   D + P ++    +E   ++ V+ G +HT+
Sbjct: 360 VTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 4/148 (2%)
 Frame = +1

Query: 1   RSRRCRGSXIKQLA-CGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG 177
           +SR  RG    Q A CG     A++  G V  +G +   QLG   TE   +PQ + +F+ 
Sbjct: 232 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 291

Query: 178 ISVKMI--AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVL 348
            +   +  + G  HT  +  +G  Y  G   YG LGLG+   ++ +P  +S +    +  
Sbjct: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSS 349

Query: 349 VACGWRHTITVSXXGSLYTYXWSKYGQL 432
           VACG      V+  G ++ +      QL
Sbjct: 350 VACGASVGYAVTKDGRVFAWGMGTNYQL 377



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 18/153 (11%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT-----------EDSLLPQTIQAFE 174
           + ++A G+ H + +T  G++ + G  + GQLG               E  L+P+ +    
Sbjct: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233

Query: 175 G-----ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD- 336
                 +  +    GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +   
Sbjct: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293

Query: 337 -KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
              V  + G  HT+ +   G  Y+   ++YG+L
Sbjct: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRL 326



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 38/123 (30%), Positives = 57/123 (46%), Gaps = 4/123 (3%)
 Frame = +1

Query: 52  SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKMIAAGAEHTAAV 225
           SH    T  G VL+ G+   GQLGLG   ++++ +   A   I   V    AG  HT  +
Sbjct: 26  SHRSHSTEPGLVLTLGQGDVGQLGLG---ENVMERKKPALVSIPEDVVQAEAGGMHTVCL 82

Query: 226 TEDGDIYGWGWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSL 399
           ++ G +Y +G    G LG          VP KV   E  K+V V+ G  HT  ++  G +
Sbjct: 83  SKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRV 140

Query: 400 YTY 408
           + +
Sbjct: 141 FLW 143



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 25/71 (35%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI--QAFEGISVKMIAA 201
           +  +ACG S   AVT  G V +WG   N QLG G  ED+  P  +  +  E   V  +++
Sbjct: 347 VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSS 406

Query: 202 GAEHTAAVTED 234
           G +HT  + +D
Sbjct: 407 GGQHTVLLVKD 417

---

>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 35/86 (40%), Positives = 50/86 (58%)
 Frame = +1

Query: 22   SXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAA 201
            S + Q+ACG  H + +T+AGEV ++G NQ GQLG G  +    P  +Q    IS   +AA
Sbjct: 966  SPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAIS--QVAA 1023

Query: 202  GAEHTAAVTEDGDIYGWGWGRYGNLG 279
            G+ HT  +T  G +Y +G  + G LG
Sbjct: 1024 GSNHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 34/96 (35%), Positives = 49/96 (51%)
 Frame = +1

Query: 145  LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 324
            L PQ +Q      V  +A G  HT  +T  G++Y +G  +YG LG GD      P +V  
Sbjct: 955  LAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRV-Q 1013

Query: 325  VEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
            V G  +  VA G  HT+ ++  G +YT+   + GQL
Sbjct: 1014 VPG-AISQVAAGSNHTVLLTSKGMVYTFGNYQKGQL 1048



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 9/133 (6%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGL---GTTEDSLLPQTIQAFEGISVKMIAAGA 207
           +ACG    L     G V  +G++    LGL   G T    L + + + +  ++  +A G 
Sbjct: 602 MACGKEFGLVRASNGRVYYYGKS--AALGLKCVGRTPTLKLTELVIS-KAANIVHVAVGH 658

Query: 208 E--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRH 369
           +  H   V +DG ++  G  R G  G   +N R      P+K++ ++G  +V  AC    
Sbjct: 659 DGIHALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGT 718

Query: 370 TITVSXXGSLYTY 408
           +  V+  G L  Y
Sbjct: 719 SAFVTKTGKLIMY 731

---

>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 42/138 (30%), Positives = 66/138 (47%), Gaps = 3/138 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           I Q A G  H + +  +G + ++G N  G LG  T+E+    Q  +      V  ++AG 
Sbjct: 75  IVQAAAGGMHTVCLGASGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAEKVVQVSAGD 134

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHTIT 378
            HTAA+TEDG ++ +G  R  N  +G         VP +V       ++ +A G  H + 
Sbjct: 135 SHTAALTEDGRVFVFGSFRDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVL 192

Query: 379 VSXXGSLYTYXWSKYGQL 432
           ++  G LYT    + GQL
Sbjct: 193 LTVDGDLYTSGCGEQGQL 210



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 37/113 (32%), Positives = 61/113 (53%), Gaps = 3/113 (2%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLG-TTEDSLLPQTIQAFEGISVKMIAAGAEHTAA 222
           G  H + V   G+  S GR + G+LGLG   E+   P  I     I+   +A+GA  + A
Sbjct: 307 GQHHTVCVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDLPKIN--SVASGASVSYA 364

Query: 223 VTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS--VEGDKMVLVACGWRHTI 375
           V+ DG ++ WG G    LG G+  D + PE+++   +E  +++ V+ G +HT+
Sbjct: 365 VSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQHTV 417



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 38/150 (25%), Positives = 70/150 (46%), Gaps = 17/150 (11%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTT-----------EDSLLPQTI----QA 168
           ++A G+ H + +T+ G++ + G  + GQLG               E  L+PQ I    + 
Sbjct: 182 KIASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLKAKG 241

Query: 169 FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 348
              +  + +  GA  T AV+++G +YG+G   Y  LG  +    + P+ ++S +      
Sbjct: 242 SGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSW 301

Query: 349 VAC--GWRHTITVSXXGSLYTYXWSKYGQL 432
           +    G  HT+ V   G  Y+   ++YG+L
Sbjct: 302 IGFSGGQHHTVCVDSEGKAYSLGRAEYGRL 331



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 37/124 (29%), Positives = 54/124 (43%), Gaps = 2/124 (1%)
 Frame = +1

Query: 43  CGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI--AAGAEHT 216
           CG     AV+  G V  +G +   QLG   T+    PQ + +F+  +   I  + G  HT
Sbjct: 252 CGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHT 311

Query: 217 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGS 396
             V  +G  Y  G   YG LGLG+ N     E     +  K+  VA G   +  VS  G 
Sbjct: 312 VCVDSEGKAYSLGRAEYGRLGLGE-NAEEQSEPTPIPDLPKINSVASGASVSYAVSTDGC 370

Query: 397 LYTY 408
           ++ +
Sbjct: 371 VFAW 374



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 5/118 (4%)
 Frame = +1

Query: 70  TMAGEVLSWGRNQNGQLGLGTTEDSL---LPQTIQAFEGISVKMIAAGAEHTAAVTEDGD 240
           T+ G+VL+ G+   GQLGLG  ED +    P  +   E   +   AAG  HT  +   G 
Sbjct: 38  TVGGQVLTLGQGDVGQLGLG--EDIMERKKPALVTLTE--DIVQAAAGGMHTVCLGASGS 93

Query: 241 IYGWGWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTY 408
           IY +G    G LG    +      P KV   E  K+V V+ G  HT  ++  G ++ +
Sbjct: 94  IYTFGCNDEGALGRDTSEEGSEMQPGKVELAE--KVVQVSAGDSHTAALTEDGRVFVF 149



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 24/65 (36%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQ--TIQAFEGISVKMIAA 201
           I  +A G S   AV+  G V +WG   N QLG G  ED   P+  T +  E   V  +++
Sbjct: 352 INSVASGASVSYAVSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSS 411

Query: 202 GAEHT 216
           G +HT
Sbjct: 412 GGQHT 416



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 26/75 (34%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
 Frame = +1

Query: 211 HTAAVTEDGDIYGWGWGRYGNLGLG-DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSX 387
           H +  T  G +   G G  G LGLG D  +R  P  V+  E   +V  A G  HT+ +  
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLTED--IVQAAAGGMHTVCLGA 90

Query: 388 XGSLYTYXWSKYGQL 432
            GS+YT+  +  G L
Sbjct: 91  SGSIYTFGCNDEGAL 105

---

>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 27/81 (33%), Positives = 42/81 (51%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
           G++  L  ++  EV +WG+ + GQLG G     L P  ++  +G  V  + AG  H+ A+
Sbjct: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574

Query: 226 TEDGDIYGWGWGRYGNLGLGD 288
           T    +Y WG   +G LG  D
Sbjct: 575 TAKSQVYSWGSNTFGQLGHSD 595



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 36/131 (27%), Positives = 56/131 (42%), Gaps = 10/131 (7%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG------- 177
           G  +  +A G  H  AVT  G    WG N  GQ  +   +    P  +   +        
Sbjct: 90  GQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA 149

Query: 178 ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF---VPEKVSSVEGDKMVL 348
           + +  +A G EHT A++   +I+ WG G      LG     F    P+KV  + G  ++ 
Sbjct: 150 VRILQLACGEEHTLALSISREIWAWGTG----CQLGLITTAFPVTKPQKVEHLAGRVVLQ 205

Query: 349 VACGWRHTITV 381
           VACG  H++ +
Sbjct: 206 VACGAFHSLAL 216



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 38/141 (26%), Positives = 66/141 (46%), Gaps = 11/141 (7%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRN--QNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
           G  + Q A G  H + +T  GEV S+G    ++G + +  +     P    A  G  V  
Sbjct: 40  GKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSS----PILENALVGQYVVT 95

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE---------KVSSVEGDKMV 345
           +A G+ H+ AVT++G  Y WG    G   +   N ++VPE         + S +   +++
Sbjct: 96  VATGSFHSGAVTDNGVAYMWGENSAGQCAVA--NQQYVPEPNPVSIADSEASPLLAVRIL 153

Query: 346 LVACGWRHTITVSXXGSLYTY 408
            +ACG  HT+ +S    ++ +
Sbjct: 154 QLACGEEHTLALSISREIWAW 174



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 1/69 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 204
           I QLACG+ H LA++++ E+ +WG     QLGL TT   +  PQ ++   G  V  +A G
Sbjct: 152 ILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209

Query: 205 AEHTAAVTE 231
           A H+ A+ +
Sbjct: 210 AFHSLALVQ 218



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 26/78 (33%), Positives = 36/78 (46%), Gaps = 4/78 (5%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----V 186
           G  +  L  G  H LA+T   +V SWG N  GQLG      S  P T+     IS    V
Sbjct: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-----HSDFPTTVPRLAKISSENGV 612

Query: 187 KMIAAGAEHTAAVTEDGD 240
             +AAG +++  + +  D
Sbjct: 613 WSVAAGRDYSLFLVDTED 630



 Score = 37.7 bits (86), Expect = 0.012
 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
 Frame = +1

Query: 145 LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG---WGRYGNLGLGDRNDRFVPEK 315
           + P+ +  + G +V   A G +H   +TEDG++Y +G   W R G + +   +    P  
Sbjct: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPSS----PIL 84

Query: 316 VSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQ 429
            +++ G  +V VA G  H+  V+  G  Y +  +  GQ
Sbjct: 85  ENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQ 122

---

>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 27/81 (33%), Positives = 42/81 (51%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
           G++  L  ++  EV +WG+ + GQLG G     L P  ++  +G  V  + AG  H+ A+
Sbjct: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574

Query: 226 TEDGDIYGWGWGRYGNLGLGD 288
           T    +Y WG   +G LG  D
Sbjct: 575 TAKSQVYSWGSNTFGQLGHSD 595



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 36/131 (27%), Positives = 56/131 (42%), Gaps = 10/131 (7%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG------- 177
           G  +  +A G  H  AVT  G    WG N  GQ  +   +    P  +   +        
Sbjct: 90  GQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA 149

Query: 178 ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF---VPEKVSSVEGDKMVL 348
           + +  +A G EHT A++   +I+ WG G      LG     F    P+KV  + G  ++ 
Sbjct: 150 VRILQLACGEEHTLALSISREIWAWGTG----CQLGLITTAFPVTKPQKVEHLAGRVVLQ 205

Query: 349 VACGWRHTITV 381
           VACG  H++ +
Sbjct: 206 VACGAFHSLAL 216



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 38/141 (26%), Positives = 66/141 (46%), Gaps = 11/141 (7%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRN--QNGQLGLGTTEDSLLPQTIQAFEGISVKM 192
           G  + Q A G  H + +T  GEV S+G    ++G + +  +     P    A  G  V  
Sbjct: 40  GKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSS----PILENALVGQYVIT 95

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE---------KVSSVEGDKMV 345
           +A G+ H+ AVT++G  Y WG    G   +   N ++VPE         + S +   +++
Sbjct: 96  VATGSFHSGAVTDNGVAYMWGENSAGQCAVA--NQQYVPEPNPVSIADSEASPLLAVRIL 153

Query: 346 LVACGWRHTITVSXXGSLYTY 408
            +ACG  HT+ +S    ++ +
Sbjct: 154 QLACGEEHTLALSISREIWAW 174



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 1/69 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 204
           I QLACG+ H LA++++ E+ +WG     QLGL TT   +  PQ ++   G  V  +A G
Sbjct: 152 ILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209

Query: 205 AEHTAAVTE 231
           A H+ A+ +
Sbjct: 210 AFHSLALVQ 218



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 27/78 (34%), Positives = 36/78 (46%), Gaps = 4/78 (5%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----V 186
           G  +  L  G  H LA+T   +V SWG N  GQLG      S  P T+     IS    V
Sbjct: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-----HSDFPTTVPRLAKISSENGV 612

Query: 187 KMIAAGAEHTAAVTEDGD 240
             IAAG +++  + +  D
Sbjct: 613 WSIAAGRDYSLFLVDTED 630



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 26/98 (26%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
 Frame = +1

Query: 145 LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG---WGRYGNLGLGDRNDRFVPEK 315
           + P+ +  + G +V   A G +H   +TEDG++Y +G   W R G + +   +    P  
Sbjct: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPSS----PIL 84

Query: 316 VSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQ 429
            +++ G  ++ VA G  H+  V+  G  Y +  +  GQ
Sbjct: 85  ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQ 122

---

>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 26/78 (33%), Positives = 41/78 (52%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAV 225
           G++  L  ++  EV +WG+ + GQLG G     L P  ++  +G  V  + AG  H+ A+
Sbjct: 509 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLAL 568

Query: 226 TEDGDIYGWGWGRYGNLG 279
           T    +Y WG   +G LG
Sbjct: 569 TAKSQVYSWGSNTFGQLG 586



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 8/129 (6%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG------- 177
           G  +  +A G  H  AVT +G V  WG N  GQ  +   +    P  +   +        
Sbjct: 90  GHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLA 149

Query: 178 ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV-PEKVSSVEGDKMVLVA 354
           + +  +A G EHT A++   +I  W WG    LGL         P+KV  + G  ++ VA
Sbjct: 150 VRILQLACGEEHTLALSLSREI--WAWGTGCQLGLITTTFPVTKPQKVEHLAGRVVLQVA 207

Query: 355 CGWRHTITV 381
           CG  H++ +
Sbjct: 208 CGAFHSLAL 216



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 39/143 (27%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWG----RNQNGQLGLGTTEDSLLPQTIQAFEGISV 186
           G  + Q A G  H + +T  GEV S+G    ++++ ++   +      P    A  G  V
Sbjct: 40  GKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEICPSS------PLLESALVGHHV 93

Query: 187 KMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE----KVSSVEGD-----K 339
             +A G+ H+ AVTE G +Y WG    G   +   N ++VPE     +S  E       +
Sbjct: 94  ITVATGSFHSGAVTESGVVYMWGENAAGQCAVA--NQQYVPEPSPVSISDSETSPSLAVR 151

Query: 340 MVLVACGWRHTITVSXXGSLYTY 408
           ++ +ACG  HT+ +S    ++ +
Sbjct: 152 ILQLACGEEHTLALSLSREIWAW 174



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 1/69 (1%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 204
           I QLACG+ H LA++++ E+ +WG     QLGL TT   +  PQ ++   G  V  +A G
Sbjct: 152 ILQLACGEEHTLALSLSREIWAWG--TGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACG 209

Query: 205 AEHTAAVTE 231
           A H+ A+ +
Sbjct: 210 AFHSLALVQ 218



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----V 186
           G  +  L  G SH LA+T   +V SWG N  GQLG      S  P T+     +S    V
Sbjct: 552 GKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLG-----HSEFPTTVPRLSKVSSENGV 606

Query: 187 KMIAAGAEHTAAVTEDGD 240
             +AAG +++  + +  D
Sbjct: 607 WSVAAGQDYSLFLVDTED 624



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
 Frame = +1

Query: 142 SLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK-- 315
           SL P+ +  + G +V   A G  H   +TEDG++Y      +G L     +    P    
Sbjct: 29  SLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYS-----FGTLPWKSESAEICPSSPL 83

Query: 316 -VSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWSKYGQ 429
             S++ G  ++ VA G  H+  V+  G +Y +  +  GQ
Sbjct: 84  LESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQ 122

---

>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 27/80 (33%), Positives = 44/80 (55%)
 Frame = +1

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            ++ G  H+  + E+GD+Y +G+G++G LG GD N R  P  V ++ G    + AC   HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTACS-NHT 965

Query: 373  ITVSXXGSLYTYXWSKYGQL 432
              +   G ++T+     GQL
Sbjct: 966  AVLLMDGQVFTFGSFSKGQL 985



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 28/82 (34%), Positives = 44/82 (53%)
 Frame = +1

Query: 34   QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEH 213
            Q++CG  H + +   G+V ++G  Q+GQLG G       P  +QA  G S + + A + H
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTACSNH 964

Query: 214  TAAVTEDGDIYGWGWGRYGNLG 279
            TA +  DG ++ +G    G LG
Sbjct: 965  TAVLLMDGQVFTFGSFSKGQLG 986



 Score = 36.2 bits (82), Expect = 0.035
 Identities = 32/131 (24%), Positives = 52/131 (39%), Gaps = 7/131 (5%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGL---GTTEDSLLPQTIQAFEGISVKMIAAGA 207
           L  G    L  T  G++   G+ Q+  LG+   G +    +   I     I    +    
Sbjct: 496 LGAGREFALMKTANGKIYYTGKYQS--LGIKQGGPSAGKWVELPITKSPKIVHFSVGHDG 553

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTI 375
            H   V EDG ++  G    G  G   ++ R    + P+K+  +EG  +V  AC    + 
Sbjct: 554 SHALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSS 613

Query: 376 TVSXXGSLYTY 408
            +S  G LY +
Sbjct: 614 VISKDGELYMF 624



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 16/59 (27%), Positives = 31/59 (52%), Gaps = 7/59 (11%)
 Frame = +1

Query: 277  GLGDRNDRFVPEKVSSVEGD-------KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
            G GDR ++   +  +   G        + V V+CG+ H++ +   G +YT+ + ++GQL
Sbjct: 876  GSGDRGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQL 934

---

>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 29/82 (35%), Positives = 45/82 (54%)
 Frame = +1

Query: 34   QLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEH 213
            Q++CG  H + +   G+V ++G  Q+GQLG G       P  +QA  G S + + AG+ H
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTAGSNH 964

Query: 214  TAAVTEDGDIYGWGWGRYGNLG 279
            TA +  DG ++ +G    G LG
Sbjct: 965  TAVLLMDGQVFTFGSFSKGQLG 986



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 27/80 (33%), Positives = 43/80 (53%)
 Frame = +1

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            ++ G  H+  + E+GD+Y +G+G++G LG GD N R  P  V ++ G     V  G  HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965

Query: 373  ITVSXXGSLYTYXWSKYGQL 432
              +   G ++T+     GQL
Sbjct: 966  AVLLMDGQVFTFGSFSKGQL 985



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 33/131 (25%), Positives = 52/131 (39%), Gaps = 7/131 (5%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQNGQLGL---GTTEDSLLPQTIQAFEGISVKMIAAGA 207
           L  G    L  T  G++   G+ Q+  LG+   G +    +   I     I    +    
Sbjct: 496 LGAGREFALMKTANGKIYYTGKYQS--LGIKQGGPSAGKWVELPITKSPKIVHFSVGHDG 553

Query: 208 EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTI 375
            H   V EDG I+  G    G  G   ++ R    + P+K+  +EG  +V  AC    + 
Sbjct: 554 SHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSS 613

Query: 376 TVSXXGSLYTY 408
            +S  G LY +
Sbjct: 614 VISKDGELYMF 624



 Score = 33.5 bits (75), Expect = 0.22
 Identities = 11/32 (34%), Positives = 22/32 (68%)
 Frame = +1

Query: 337 KMVLVACGWRHTITVSXXGSLYTYXWSKYGQL 432
           + V V+CG+ H++ +   G +YT+ + ++GQL
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQL 934

---

>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 36/107 (33%), Positives = 52/107 (48%), Gaps = 1/107 (0%)
 Frame = +1

Query: 85  VLSWGRNQNGQLGLGTTEDSLLPQ-TIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWG 261
           V ++G N   QLGLG  ED   PQ ++   +G  V+ IA G  H+  +T DG++ G G  
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 262 RYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
           R G L       +    +   V    +V VACGW  T+ V   G ++
Sbjct: 64  RRGELDSAQALRQVHDWRPVEVPAP-VVDVACGWDTTVIVDADGRVW 109



 Score = 36.2 bits (82), Expect = 0.035
 Identities = 21/87 (24%), Positives = 43/87 (49%), Gaps = 4/87 (4%)
 Frame = +1

Query: 19  GSXIKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM-- 192
           G+ ++++ACG +H + +T  G ++  G N+ G+L     + +   + +  +  + V    
Sbjct: 35  GAIVRKIACGGNHSVMLTNDGNLVGCGDNRRGEL-----DSAQALRQVHDWRPVEVPAPV 89

Query: 193 --IAAGAEHTAAVTEDGDIYGWGWGRY 267
             +A G + T  V  DG ++  G G Y
Sbjct: 90  VDVACGWDTTVIVDADGRVWQRGGGCY 116



 Score = 33.5 bits (75), Expect = 0.22
 Identities = 21/67 (31%), Positives = 34/67 (50%), Gaps = 3/67 (4%)
 Frame = +1

Query: 241 IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLV---ACGWRHTITVSXXGSLYTYX 411
           +Y +G      LGLG   D   P++  SV GD   +V   ACG  H++ ++  G+L    
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQR--SVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCG 61

Query: 412 WSKYGQL 432
            ++ G+L
Sbjct: 62  DNRRGEL 68



 Score = 33.1 bits (74), Expect = 0.29
 Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
 Frame = +1

Query: 133 TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGD-------IYGWGWGRYGNLG 279
           T   L PQ    F  + V   A G+EH    T + +       +Y WGWG +GN G
Sbjct: 249 THSQLFPQERLDFPIVGV---ATGSEHGILTTANQEGKSHCYNVYCWGWGEHGNCG 301

---

>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 38/126 (30%), Positives = 66/126 (52%), Gaps = 13/126 (10%)
 Frame = +1

Query: 46  GDSHCLAVTMAGEVLSWGRNQNGQLGLGT-----TEDSLLPQTIQAFEGISVKMIAAGAE 210
           G  H + +   G+V + G+N +  LGLG       +   L  TIQ  E  S K++   A+
Sbjct: 442 GVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDS-KIVGVSAK 500

Query: 211 HTAAV--TEDGDIYGWGWGRYGNLGLG--DRNDRFV--PEKVSS--VEGDKMVLVACGWR 366
              ++  +EDG  Y WG+   G LGLG  D +++ V  PE++SS  ++G  ++  +   +
Sbjct: 501 LATSIAWSEDGTAYAWGFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGYSIIGASISDQ 560

Query: 367 HTITVS 384
           HT+ ++
Sbjct: 561 HTLIIA 566



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 40/144 (27%), Positives = 63/144 (43%), Gaps = 11/144 (7%)
 Frame = +1

Query: 34  QLACGDSHCLAVTMAGEVLSWGRNQNGQLGL------GTTEDSLLPQTIQAFEGIS-VKM 192
           Q   G  H   +T  GEV   G N+ G +        G+T++    +  +  E    + M
Sbjct: 189 QAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEKEGKIVM 248

Query: 193 IAAGAEHTAAVTEDGDIYGWGWGR--YGNLGLGDRNDRF--VPEKVSSVEGDKMVLVACG 360
           +AAGA  TAA+T+ G +  WG  R   GN+ +     +    P  +      K+V +A G
Sbjct: 249 LAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKIAAG 308

Query: 361 WRHTITVSXXGSLYTYXWSKYGQL 432
             H + +   G L T+   + GQL
Sbjct: 309 ENHLVMLDEKGCLLTFGDGEMGQL 332



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 33/137 (24%), Positives = 54/137 (39%), Gaps = 19/137 (13%)
 Frame = +1

Query: 79  GEVLSWGRNQNGQLGLGTTEDSL-------------LPQTIQAFEGISVKMIAAGAEHTA 219
           G+  ++G N   QLG+   E  +             LP    AF      +   G +H  
Sbjct: 388 GKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLPAEAPAFGAERTFVNIEGVQHVV 447

Query: 220 AVTEDGDIYGWGWGRYGNLGLG-----DRNDRFVPEKVSSVEGD-KMVLVACGWRHTITV 381
            +  DG ++  G      LGLG     D    ++ + +  +E D K+V V+     +I  
Sbjct: 448 ILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDSKIVGVSAKLATSIAW 507

Query: 382 SXXGSLYTYXWSKYGQL 432
           S  G+ Y + +   GQL
Sbjct: 508 SEDGTAYAWGFDTTGQL 524



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 32/155 (20%), Positives = 61/155 (39%), Gaps = 30/155 (19%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--------------LLPQTIQ 165
           I ++A G++H + +   G +L++G  + GQLG  +   +              L+P   +
Sbjct: 302 IVKIAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFK 361

Query: 166 ---AFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL--------GDRNDR---- 300
               F  +  K + A    T    EDG  Y +G   Y  LG+         D  D     
Sbjct: 362 HKGKFFDVVAKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELR 421

Query: 301 -FVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLY 402
            F+P +  +   ++  +   G +H + +   G ++
Sbjct: 422 VFLPAEAPAFGAERTFVNIEGVQHVVILGSDGKVF 456



 Score = 33.9 bits (76), Expect = 0.17
 Identities = 33/119 (27%), Positives = 53/119 (44%), Gaps = 11/119 (9%)
 Frame = +1

Query: 85  VLSWGRNQN-GQLGLGTTEDSLLPQTIQAFE--GISVKMIAAGAEHTAAVTEDGDIYGWG 255
           VLS G  +  G  G  TT+    P+ +  FE  G+      AG  H+A +T +G++Y  G
Sbjct: 154 VLSCGEGEALGHPGRTTTKK---PRKVDIFEEEGLKPLQAVAGGVHSAVLTSEGEVYMCG 210

Query: 256 WGRYGNL--------GLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTY 408
               G +        G  D   +   E+    EG K+V++A G   T  ++  GS+  +
Sbjct: 211 INEKGTVPAEGVEKEGSTDEFAKVKFEEDIEKEG-KIVMLAAGASFTAALTDQGSVIAW 268

---

>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 3/101 (2%)
 Frame = +1

Query: 28   IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
            +  ++CG+ H + +     V ++G N +GQLG+G T     PQ +       +  +AAG+
Sbjct: 769  VSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAGS 828

Query: 208  EHTAAVTEDGDIYGWGWGRYGNLG--LGDRND-RFVPEKVS 321
             HT     DG ++ +G    G L    G++     +PEKVS
Sbjct: 829  NHTILRANDGSVFTFGAFGKGQLARPAGEKAGWNAIPEKVS 869



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 40/140 (28%), Positives = 63/140 (45%), Gaps = 11/140 (7%)
 Frame = +1

Query: 46   GDSHCLAVTMA---GEVLSW---GRNQNGQLG--LGTTEDSLLPQTIQAFEG---ISVKM 192
            G+S CL   +    GEV      GR Q+ Q          +L P  +   +G   + V  
Sbjct: 712  GESTCLRCGLCRPCGEVTEPAQPGRAQHVQFSSTAAPQRSTLHPSRVILSQGPHDVKVSS 771

Query: 193  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 372
            ++ G  HT  +  D  ++ +G   +G LG+GD   +  P++V       +V VA G  HT
Sbjct: 772  VSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAGSNHT 831

Query: 373  ITVSXXGSLYTYXWSKYGQL 432
            I  +  GS++T+     GQL
Sbjct: 832  ILRANDGSVFTFGAFGKGQL 851



 Score = 35.8 bits (81), Expect = 0.045
 Identities = 16/62 (25%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
 Frame = +1

Query: 103 NQNGQL---GLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 273
           ++NG++   GL T   ++  Q +   + + +  +A G  H  AVT +G ++ WG      
Sbjct: 585 SENGKIFMGGLHTMRVNVSSQMLNGLDNVMISSLALGKSHGVAVTRNGHLFTWGLNNMNQ 644

Query: 274 LG 279
            G
Sbjct: 645 CG 646



 Score = 32.7 bits (73), Expect = 0.38
 Identities = 15/32 (46%), Positives = 18/32 (56%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLG 123
           I  LA G SH +AVT  G + +WG N   Q G
Sbjct: 615 ISSLALGKSHGVAVTRNGHLFTWGLNNMNQCG 646

---

>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 28/88 (31%), Positives = 43/88 (48%), Gaps = 12/88 (13%)
 Frame = +1

Query: 157 TIQAFEGISVKM------------IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR 300
           T+QAF+ +  +M             A G  H   V E G I+  G  RYG LG GD+ DR
Sbjct: 338 TLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDR 397

Query: 301 FVPEKVSSVEGDKMVLVACGWRHTITVS 384
             P +V  ++  + + + CG  H++ +S
Sbjct: 398 GEPTQVCYLQ--RPITLWCGLNHSLVLS 423

---

>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 28/88 (31%), Positives = 43/88 (48%), Gaps = 12/88 (13%)
 Frame = +1

Query: 157 TIQAFEGISVKM------------IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR 300
           T+QAF+ +  +M             A G  H   V E G I+  G  RYG LG GD+ DR
Sbjct: 348 TLQAFDPLDHQMPLALSLPAKVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDR 407

Query: 301 FVPEKVSSVEGDKMVLVACGWRHTITVS 384
             P +V  ++  + + + CG  H++ +S
Sbjct: 408 GEPTQVHYLQ--RPIALWCGLNHSLVLS 433



 Score = 28.1 bits (61), Expect = 9.4
 Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 6/85 (7%)
 Frame = +1

Query: 40  ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGAEH 213
           A G +H   V   G +   G N+ GQLG G   D   P  +   +    + IA   G  H
Sbjct: 373 ALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQ----RPIALWCGLNH 428

Query: 214 TAAVTEDGD----IYGWGWGRYGNL 276
           +  +++  D    + G G G  G L
Sbjct: 429 SLVLSQTSDFSKELLGCGCGAGGRL 453

---

>TMPS9_RAT (P69526) Transmembrane protease, serine 9 (EC 3.4.21.-)|
            (Polyserase-1) (Polyserine protease 1) (Polyserase-I)
            [Contains: Serase-1; Serase-2; Serase-3]
          Length = 1061

 Score = 37.4 bits (85), Expect = 0.016
 Identities = 37/141 (26%), Positives = 55/141 (39%), Gaps = 24/141 (17%)
 Frame = -3

Query: 362  HPHATSTILSPSTEDTFS--GTNRSFRSPRP-------KFPYRPQPHP*ISPSSVTAAVC 210
            HPH +ST L PS   T +  G      + RP       +   RP      + S+ T    
Sbjct: 746  HPHTSSTRLIPSQPPTTTAAGLIPEASTGRPATLRATIRVTTRPLNTTLSARSTTTRRQT 805

Query: 209  SAPAAIIFTEIPSKA*IVCGSSESSVVPR---------PSWPF----WLRPQLSTSPAMV 69
             AP   +F+ +P      CG +    + R           WP+    WLR +     A++
Sbjct: 806  PAPGTTVFSHLPD-----CGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVL 860

Query: 68   TARQWLSPQASCLXL--DPLQ 12
             A +WL   A C  +  DP+Q
Sbjct: 861  VAERWLLSAAHCFDVYGDPMQ 881

---

>TMPS9_MOUSE (P69525) Transmembrane protease, serine 9 (EC 3.4.21.-)|
            (Polyserase-1) (Polyserine protease 1) (Polyserase-I)
            [Contains: Serase-1; Serase-2; Serase-3]
          Length = 1065

 Score = 33.9 bits (76), Expect = 0.17
 Identities = 39/144 (27%), Positives = 57/144 (39%), Gaps = 28/144 (19%)
 Frame = -3

Query: 359  PHATSTILSPST--EDTFSG------TNRSFRSPRPKFPYRPQP-HP*ISPSSVTA---- 219
            PH +ST L PS   + T +G      T     +PR       +P +  +S  S T     
Sbjct: 747  PHTSSTRLIPSEPPKTTAAGLIIPEATTSRLATPRATIRVTTRPLNTTLSARSTTTRGQT 806

Query: 218  AVCSAPAAIIFTEIPSKA*IVCGSSESSVVPR---------PSWPF----WLRPQLSTSP 78
            A  SAP   I + +P      CG +    + R           WP+    WLR +     
Sbjct: 807  AAPSAPGTTIHSHLPD-----CGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCG 861

Query: 77   AMVTARQWLSPQASCLXL--DPLQ 12
            A++ A +WL   A C  +  DP+Q
Sbjct: 862  AVLVAERWLLSAAHCFDIYGDPMQ 885

---

>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 33.1 bits (74), Expect = 0.29
 Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
 Frame = +1

Query: 181 SVKMIAAGAEHTAAVTEDGDIYGWGWGRY--GNLGLGDRNDRFVPE-KVSSVEGDKMVLV 351
           +V  +A+G  HT A+TE G +Y WG      G LGLG  +++ V E  + + EG + + V
Sbjct: 547 NVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGP-SEKIVNELHIGNWEGQRNIRV 605



 Score = 31.6 bits (70), Expect = 0.85
 Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 2/49 (4%)
 Frame = +1

Query: 37  LACGDSHCLAVTMAGEVLSWGRNQN--GQLGLGTTEDSLLPQTIQAFEG 177
           +A GD H +A+T  G + SWG      G LGLG +E  +    I  +EG
Sbjct: 551 VASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEG 599

---

>BAZ2A_MOUSE (Q91YE5) Bromodomain adjacent to zinc finger domain 2A|
           (Transcription termination factor I-interacting protein
           5) (TTF-I-interacting protein 5) (Tip5)
          Length = 1850

 Score = 32.7 bits (73), Expect = 0.38
 Identities = 31/119 (26%), Positives = 45/119 (37%), Gaps = 12/119 (10%)
 Frame = -3

Query: 323 EDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAPAAI-------IFTEIPSKA 165
           E   S   R    P P  P   Q HP +SP++  AA  +A A I         + +P + 
Sbjct: 359 ETQSSNFQRPLTEPAPDQPPSTQLHPAVSPTASPAASLTASAEISPAVSPVASSPVPPEV 418

Query: 164 *IVCGSSESSVVPRPSWPFWL-----RPQLSTSPAMVTARQWLSPQASCLXLDPLQRLD 3
            +    + S  +P  S    +      PQ S  P+   A Q +SP    +   P  R D
Sbjct: 419 FVAVSPASSPALPAISLEASMTTPVTSPQGSPEPSPAAAFQTVSPARKNVSSAPKARAD 477

---

>COA1_BOVIN (Q9TTS3) Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha)|
           [Includes: Biotin carboxylase (EC 6.3.4.14)]
          Length = 2346

 Score = 32.3 bits (72), Expect = 0.50
 Identities = 31/131 (23%), Positives = 47/131 (35%), Gaps = 5/131 (3%)
 Frame = +1

Query: 40  ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM-IAAGAEHT 216
           A G  H  A +  G   SWG N+          +  +   + A + +S++       E+ 
Sbjct: 545 AAGGLHEFADSQFGHCFSWGENR----------EEAISNMVVALKELSIRGDFRTTVEYL 594

Query: 217 AAVTEDGDIY----GWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 384
             + E         G GW            DR + EKV +   D M+ V CG  H   VS
Sbjct: 595 IKLLETESFQLNRIGTGW-----------LDRLIAEKVQAERPDTMLGVVCGALHVADVS 643

Query: 385 XXGSLYTYXWS 417
              S+  +  S
Sbjct: 644 LRNSISNFLHS 654

---

>HCN1_RAT (Q9JKB0) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1
          Length = 910

 Score = 31.2 bits (69), Expect = 1.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 335 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 201
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 653 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 696

---

>HCN1_MOUSE (O88704) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (Brain cyclic nucleotide
           gated channel 1) (BCNG-1) (Hyperpolarization-activated
           cation channel 2) (HAC-2)
          Length = 910

 Score = 31.2 bits (69), Expect = 1.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 335 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 201
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 653 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 696

---

>HCN1_RABIT (Q9MZS1) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (rbHCN1)
          Length = 822

 Score = 31.2 bits (69), Expect = 1.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 335 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 201
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 600 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 643

---

>HCN1_HUMAN (O60741) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (Brain cyclic nucleotide
           gated channel 1) (BCNG-1)
          Length = 890

 Score = 31.2 bits (69), Expect = 1.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 335 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 201
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 664 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 707

---

>VGLD_PRVRI (P07645) Protein gp50|
          Length = 402

 Score = 30.8 bits (68), Expect = 1.5
 Identities = 15/43 (34%), Positives = 22/43 (51%)
 Frame = -3

Query: 359 PHATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPS 231
           P     +  P+T D  +G   + R PRP+ P+RP   P + PS
Sbjct: 288 PAPPDRLPEPATRDHAAGGRPTPRPPRPETPHRPFAPPAVVPS 330

---

>COAC_CHICK (P11029) Acetyl-CoA carboxylase (EC 6.4.1.2) (ACC) [Includes:|
           Biotin carboxylase (EC 6.3.4.14)]
          Length = 2324

 Score = 30.0 bits (66), Expect = 2.5
 Identities = 31/126 (24%), Positives = 49/126 (38%)
 Frame = +1

Query: 40  ACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTA 219
           A G  H  A +  G   SWG N+  +  +     +L   +I+     +V+ +    E T 
Sbjct: 545 AAGGLHEFADSQFGHCFSWGENR--EEAISNMVVALKELSIRGDFRTTVEYLIKLLE-TE 601

Query: 220 AVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSL 399
           +  ++    GW              DR + EKV +   D M+ V CG  H   VS   S+
Sbjct: 602 SFQQNRIDTGW-------------LDRLIAEKVQAERPDTMLGVVCGALHVADVSFRNSV 648

Query: 400 YTYXWS 417
             +  S
Sbjct: 649 SNFLHS 654

---

>POF9_SCHPO (O74381) F-box protein pof9|
          Length = 467

 Score = 30.0 bits (66), Expect = 2.5
 Identities = 18/37 (48%), Positives = 21/37 (56%), Gaps = 2/37 (5%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQN--GQLGLGT 132
           IKQLA GD H L +T    + SWG      G LGLG+
Sbjct: 339 IKQLAHGDHHHLYLTSDHSIWSWGVELRYCGCLGLGS 375

---

>COA1_SHEEP (Q28559) Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha)|
           [Includes: Biotin carboxylase (EC 6.3.4.14)]
          Length = 2346

 Score = 29.6 bits (65), Expect = 3.2
 Identities = 15/41 (36%), Positives = 20/41 (48%)
 Frame = +1

Query: 295 DRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWS 417
           DR + EKV +   D M+ V CG  H   VS   S+  +  S
Sbjct: 614 DRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSISNFLHS 654

---

>TMPS9_HUMAN (Q7Z410) Transmembrane protease, serine 9 (EC 3.4.21.-)|
            (Polyserase-1) (Polyserase-I) (Polyserine protease 1)
            [Contains: Serase-1; Serase-2; Serase-3]
          Length = 1059

 Score = 29.3 bits (64), Expect = 4.2
 Identities = 34/123 (27%), Positives = 48/123 (39%), Gaps = 7/123 (5%)
 Frame = -3

Query: 359  PHATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCS-APAAIIFT 183
            P A S +       T S  + + R   P FP  P+     + +      C  APAA+   
Sbjct: 774  PGAASRVTGQPANSTLSAVSTTARGQTP-FPDAPE-----ATTHTQLPDCGLAPAALTR- 826

Query: 182  EIPSKA*IVCGSSESSVVPRPSWPF----WLRPQLSTSPAMVTARQWLSPQASCLXL--D 21
                   IV GS+      R  WP+    WLR +     A++ A +WL   A C  +  D
Sbjct: 827  -------IVGGSAAG----RGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875

Query: 20   PLQ 12
            P Q
Sbjct: 876  PKQ 878

---

>HOXH_RALEU (P22320) NAD-reducing hydrogenase hoxS beta subunit (EC 1.12.1.2)|
          Length = 487

 Score = 29.3 bits (64), Expect = 4.2
 Identities = 25/93 (26%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
 Frame = -2

Query: 291 PITKTQVSISTPAPSIDIAIFSYCSSMFGTSSNH-LHRNTLKSLNRLW-----EQRIFSS 130
           P+ +  V+ S P P    A+  + +   G ++N  LH N  +++  L      ++ +   
Sbjct: 303 PLGRMNVTKSLPTPLAQEALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELLHDP 362

Query: 129 SKTKLAILVTPPTEHFTGHGDGQAVAIPTG*LL 31
              K  +++TPP   +TG G G  V  P G LL
Sbjct: 363 DLQKDQLVLTPPPNAWTGEGVG-VVEAPRGTLL 394

---

>PLDP1_ARATH (Q9LRZ5) Phospholipase D p1 (EC 3.1.4.4) (AtPLDp1) (Phospholipase|
           D1 PHOX and PX containing domain) (Phospholipase D zeta
           1) (PLDzeta1)
          Length = 1096

 Score = 29.3 bits (64), Expect = 4.2
 Identities = 8/18 (44%), Positives = 11/18 (61%)
 Frame = +3

Query: 195 CCWCRTYCCSN*RWRYLW 248
           CC C  +CC N  W+ +W
Sbjct: 239 CCGCCWFCCCNDNWQKVW 256

---

>SRBS1_HUMAN (Q9BX66) Sorbin and SH3 domain-containing protein 1 (Ponsin)|
           (c-Cbl-associated protein) (CAP) (SH3 domain protein 5)
           (SH3P12)
          Length = 1292

 Score = 28.9 bits (63), Expect = 5.5
 Identities = 18/65 (27%), Positives = 28/65 (43%)
 Frame = -3

Query: 365 RHPHATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAPAAIIF 186
           R PH +    +  +    S T  SF  P P  P  P+    +S   +T AV S  ++ + 
Sbjct: 217 RWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLL 276

Query: 185 TEIPS 171
            E+ S
Sbjct: 277 NEVSS 281

---

>RERE_HUMAN (Q9P2R6) Arginine-glutamic acid dipeptide repeats protein|
            (Atrophin-1-like protein) (Atrophin-1-related protein)
          Length = 1566

 Score = 28.9 bits (63), Expect = 5.5
 Identities = 32/104 (30%), Positives = 38/104 (36%), Gaps = 11/104 (10%)
 Frame = -3

Query: 290  RSPRPKFPYRPQPHP*ISPSSVTAAVCSAPA----AIIFTEIPSKA*IVCGSSESSVVPR 123
            R P P  P  P PHP + P + +A   SAP+     +     P    +  G       P 
Sbjct: 810  RPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQH--PG 867

Query: 122  PSWPFWLRPQ-------LSTSPAMVTARQWLSPQASCLXLDPLQ 12
            P  PF L PQ       L TSPA       L   AS   L   Q
Sbjct: 868  PPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQ 911

---

>MDC1_HUMAN (Q14676) Mediator of DNA damage checkpoint protein 1 (Nuclear factor|
            with BRCT domains 1)
          Length = 2089

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 13/30 (43%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
 Frame = -3

Query: 332  PSTEDTFSGTNRS-FRSPRPKFPYRPQPHP 246
            P++  T   TNRS  ++P P  P  P+PHP
Sbjct: 1592 PTSRATRCRTNRSSVKTPEPVVPTAPEPHP 1621

---

>DDX20_MOUSE (Q9JJY4) Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-)|
           (DEAD box protein 20) (DEAD box protein DP 103)
           (Component of gems 3) (Gemin-3) (Regulator of
           steroidogenic factor 1) (ROSF-1)
          Length = 825

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
 Frame = -3

Query: 362 HPHATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAPAAIIFT 183
           H +++ T+ + S +       R+F+S R      P      SP + +A+  SA       
Sbjct: 461 HTYSSPTVATQSPKKQVQKLERAFQSQRTPGNQTP------SPRNTSASALSARPKHSKP 514

Query: 182 EIPSKA*IVCGSSESSVVPRPS-WPFWLRPQLSTS 81
           ++P K+   CG  E +  P+ S  P  L  Q+  S
Sbjct: 515 KLPVKSHSECGVLEKAAPPQESGCPAQLEEQVKNS 549

---

>MDC1_PANTR (Q7YR40) Mediator of DNA damage checkpoint protein 1|
          Length = 2171

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 13/30 (43%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
 Frame = -3

Query: 332  PSTEDTFSGTNRS-FRSPRPKFPYRPQPHP 246
            P++  T   TNRS  ++P P  P  P+PHP
Sbjct: 1674 PTSRATRCRTNRSSVKTPEPVVPTAPEPHP 1703

---

>COAC_SCHPO (P78820) Acetyl-CoA carboxylase (EC 6.4.1.2) (ACC) (Cell untimely|
           torn protein 6) [Includes: Biotin carboxylase (EC
           6.3.4.14)]
          Length = 2280

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 11/22 (50%), Positives = 15/22 (68%)
 Frame = +1

Query: 295 DRFVPEKVSSVEGDKMVLVACG 360
           DR + +KV+S   DKM+ V CG
Sbjct: 573 DRLIAQKVTSARPDKMLAVVCG 594

---

>PDC6I_XENLA (Q9W6C5) Programmed cell death 6-interacting protein (Signal|
           transduction protein Xp95)
          Length = 867

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 26/81 (32%), Positives = 34/81 (41%)
 Frame = -3

Query: 353 ATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAPAAIIFTEIP 174
           ATS+I +P+    FS        PRP  P  P   P   P+S   A   AP A   +  P
Sbjct: 739 ATSSIPTPAPRTVFSAKQ---PPPRPPPPAMPSASP--VPASAAQASNPAPTAAADSSQP 793

Query: 173 SKA*IVCGSSESSVVPRPSWP 111
               I    S++   P PS+P
Sbjct: 794 PSNTI---PSQAQGPPYPSYP 811

---

>COA1_RAT (P11497) Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha)|
           [Includes: Biotin carboxylase (EC 6.3.4.14)]
          Length = 2345

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 14/41 (34%), Positives = 20/41 (48%)
 Frame = +1

Query: 295 DRFVPEKVSSVEGDKMVLVACGWRHTITVSXXGSLYTYXWS 417
           DR + EKV +   D M+ V CG  H   V+   S+  +  S
Sbjct: 613 DRLIAEKVQAERPDTMLGVVCGALHVADVNLRNSISNFLHS 653

---

>MTF1_HUMAN (Q14872) Metal-regulatory transcription factor 1 (Transcription|
           factor MTF-1) (MRE-binding transcription factor)
          Length = 753

 Score = 28.5 bits (62), Expect = 7.2
 Identities = 18/61 (29%), Positives = 26/61 (42%)
 Frame = -3

Query: 269 PYRPQPHP*ISPSSVTAAVCSAPAAIIFTEIPSKA*IVCGSSESSVVPRPSWPFWLRPQL 90
           P  P P P + P S  AA  + PA +   E+P        ++    +P P  P  + P L
Sbjct: 440 PSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPQPIVPGL 499

Query: 89  S 87
           S
Sbjct: 500 S 500

---

>TAM_ECOLI (P76145) Trans-aconitate 2-methyltransferase (EC 2.1.1.144)|
          Length = 251

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 20/79 (25%), Positives = 33/79 (41%), Gaps = 10/79 (12%)
 Frame = -3

Query: 209 SAPAAIIFTEIPSK-----A*IVCGSSESSVVPRPSWPFWLRPQLSTSPAMVTARQWLSP 45
           S PA  +   +P +     A + CG   S+ + +  WP      + +SPAM+   +   P
Sbjct: 16  SRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALP 75

Query: 44  QASCLXLD-----PLQRLD 3
               +  D     P+Q LD
Sbjct: 76  DCQFVEADIRNWQPVQALD 94

---

>PALB_NEUCR (Q7RZP7) Calpain-like protease palB/rim-13 (EC 3.4.22.-) (Cysteine|
            protease rim-13)
          Length = 986

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 19/58 (32%), Positives = 25/58 (43%)
 Frame = +1

Query: 97   GRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 270
            G   +  LGL T E  L P  I+ + G+ + +   G      VTE  D  G G G  G
Sbjct: 905  GEFADASLGLRTREVDLDPDVIRVYGGLWLVVEQIGGGGQGHVTEGSDDDGGGGGGGG 962

---

>YVAP_VACCC (P20525) Hypothetical 9.9 kDa protein|
          Length = 89

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 20/71 (28%), Positives = 29/71 (40%), Gaps = 7/71 (9%)
 Frame = -2

Query: 234 IFSYCSSMFGTSSNHLHRNTLKSLNRLWEQRIFSSSKTKLAI-------LVTPPTEHFTG 76
           ++S CS  F   SNHL  +    +  L +  I SSS    ++          P  +H  G
Sbjct: 5   LYSRCSFSFSFISNHLTPDGPSKIGWLDKGFIISSSTLYFSMTSNVVCETTFPAGKHIPG 64

Query: 75  HGDGQAVAIPT 43
            GDG     P+
Sbjct: 65  AGDGNCFVYPS 75

---

>Y2082_MYCTU (Q10690) Hypothetical protein Rv2082|
          Length = 721

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 23/79 (29%), Positives = 33/79 (41%), Gaps = 4/79 (5%)
 Frame = -3

Query: 269 PYRPQPHP*ISPSSVTAAVCSAPAAIIFTEIPSKA*IVCGSSESSVVPRPSWPFWLRPQL 90
           P RP+P   ++   +T+   ++PA   F   PS       +S     P P+ PF   P +
Sbjct: 184 PARPRP---VTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMV 240

Query: 89  ----STSPAMVTARQWLSP 45
               STS    TA    SP
Sbjct: 241 LSSSSTSSGPPTAPTPTSP 259

---

>HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (Protein|
           hyperplastic discs)
          Length = 2885

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 18/66 (27%), Positives = 24/66 (36%)
 Frame = +1

Query: 58  CLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDG 237
           C  VT    V +W   Q G +G               F   S+  I   + +T   TE  
Sbjct: 424 CSVVTETNRVATWMDEQLGYIGAKLEHSCC---AFNEFISDSITKIYVCSLYTVVKTESN 480

Query: 238 DIYGWG 255
           +IY WG
Sbjct: 481 NIYWWG 486

---

>YJQ0_YEAST (P46999) Uncharacterized protein YJL160C precursor|
          Length = 287

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 2/94 (2%)
 Frame = +1

Query: 28  IKQLACGDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 207
           IK  AC  S  LA+T+ G VL    + +G++G      S++      F+G          
Sbjct: 185 IKVQACKSSGTLAITLQGGVLI---DSSGRIG------SIVANRQFQFDG---------- 225

Query: 208 EHTAAVTEDGDIYGWGWG--RYGNLGLGDRNDRF 303
                  + G IY  GW   ++G L +GD ND F
Sbjct: 226 ----PPPQAGAIYAGGWSITKHGTLAIGD-NDVF 254

---

>GLNE_CORDI (Q6NG61) Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42)|
           ([Glutamate--ammonia-ligase] adenylyltransferase)
           (Glutamine-synthetase adenylyltransferase) (ATase)
          Length = 1054

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
 Frame = -2

Query: 342 HLVSLHRRYFFRN--KSVIPITKTQVSISTPAPSIDIAIFSYCSSMFGTSSNHLH 184
           H+ SLHR+ F+R    SV+ I+   + +S  A  + +A   Y       + +HLH
Sbjct: 522 HISSLHRKLFYRPLLDSVVNISVGTLKLSPAAAKLQLAALGYVFP--DRAMDHLH 574

---

>DEOR_BACSU (P39140) Deoxyribonucleoside regulator|
          Length = 313

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 12/31 (38%), Positives = 17/31 (54%)
 Frame = +1

Query: 169 FEGISVKMIAAGAEHTAAVTEDGDIYGWGWG 261
           + GI+  +   GAE+     +DGDI G  WG
Sbjct: 87  YAGITHDLSRYGAEYMHETVKDGDIVGVSWG 117

---

>CP74A_ARATH (Q96242) Cytochrome P450 74A, chloroplast precursor (EC 4.2.1.92)|
           (Allene oxide synthase) (Hydroperoxide dehydrase)
          Length = 518

 Score = 28.1 bits (61), Expect = 9.4
 Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 12/103 (11%)
 Frame = +1

Query: 73  MAGEVLSWGRNQNGQLGLGTTEDSLLPQTI-----------QAFEGISVKMIAAGAEHTA 219
           +A E+ S  ++  G+L +G  E   L +++            A  G + K +   +   A
Sbjct: 348 LAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIESHDAA 407

Query: 220 AVTEDGD-IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 345
              + G+ +YG+      +  + DR D FVPE+    EG+K++
Sbjct: 408 FKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLL 450


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,078,425
Number of Sequences: 219361
Number of extensions: 1449299
Number of successful extensions: 5533
Number of sequences better than 10.0: 82
Number of HSP's better than 10.0 without gapping: 4779
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5308
length of database: 80,573,946
effective HSP length: 101
effective length of database: 58,418,485
effective search space used: 2453576370
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

---