ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags5n10 |
|---|---|
| Clone Library Name | barley_pub |
>MRP4_ARATH (Q7DM58) Multidrug resistance-associated protein 4 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 4) (ATP-energized glutathione S-conjugate pump 4) Length = 1516 Score = 291 bits (745), Expect = 1e-78 Identities = 135/213 (63%), Positives = 177/213 (83%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YLA+SRELTR++ +TKAP+I HF+E++ G TIR F+K+ F QEN+ R+N +LRM FHN Sbjct: 1113 YLASSRELTRMDSITKAPIIHHFSESIAGVMTIRSFRKQELFRQENVKRVNDNLRMDFHN 1172 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +NEWLGFRLEL+G+ VL I+A M+ LPSN I+ E VG+SLSYGLSLNS+++FAI +S Sbjct: 1173 NGSNEWLGFRLELVGSWVLCISALFMVLLPSNVIRPENVGLSLSYGLSLNSVLFFAIYMS 1232 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C +EN MV+VER+ QF+ +PSE+EW++++ LP NWP +G++ + DLKVRYRPNTPL+LK Sbjct: 1233 CFVENKMVSVERIKQFTDIPSESEWERKETLPPSNWPFHGNVHLEDLKVRYRPNTPLVLK 1292 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI + I+GGEK+GVVGRTGSGKSTLIQ LFRLV Sbjct: 1293 GITLDIKGGEKVGVVGRTGSGKSTLIQVLFRLV 1325 Score = 30.8 bits (68), Expect = 3.6 Identities = 13/31 (41%), Positives = 20/31 (64%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L IN ++ GE +VG GSGKS+L+ ++ Sbjct: 659 LSDINFKVKKGELTAIVGTVGSGKSSLLASV 689
>MRP10_ARATH (Q9LZJ5) Multidrug resistance-associated protein 10 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 10) (ATP-energized glutathione S-conjugate pump 10) Length = 1539 Score = 290 bits (742), Expect = 3e-78 Identities = 137/213 (64%), Positives = 175/213 (82%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YLA+SRELTRL+ +TKAPVI HF+E++ G TIR FKK+ F QEN+ R+N++LRM FHN Sbjct: 1136 YLASSRELTRLDSITKAPVIHHFSESIAGVMTIRAFKKQPMFRQENVKRVNANLRMDFHN 1195 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +NEWLGFRLELIG+ VL I+A M+ LPSN IK E VG+SLSYGLSLN ++++AI +S Sbjct: 1196 NGSNEWLGFRLELIGSWVLCISALFMVMLPSNIIKPENVGLSLSYGLSLNGVLFWAIYLS 1255 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C +EN MV+VER+ QF+ +P+EA+W+ ++ P PNWP G+I + D+KVRYRPNTPL+LK Sbjct: 1256 CFIENKMVSVERIKQFTDIPAEAKWEIKESRPPPNWPYKGNIRLEDVKVRYRPNTPLVLK 1315 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 G+ + I+GGEKIGVVGRTGSGKSTLIQ LFRLV Sbjct: 1316 GLTIDIKGGEKIGVVGRTGSGKSTLIQVLFRLV 1348 Score = 32.3 bits (72), Expect = 1.2 Identities = 36/156 (23%), Positives = 66/156 (42%), Gaps = 12/156 (7%) Frame = +2 Query: 200 WLG-FRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAI------- 355 WL F + G +++ + ++IS + F F+G+ L G + F I Sbjct: 537 WLSKFLYSIAGNIIVLWSTPVLISALT-FTTAVFLGVKLDAGTVFTTTTIFKILQEPIRT 595 Query: 356 --SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRY--RP 523 L M+++ R++ + E +E S N ++I D + Sbjct: 596 FPQSMISLSQAMISLGRLDAYMM---SRELSEETVERSQGCDGNVAVEIKDGSFSWDDED 652 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + P I + IN ++ GE +VG GSGKS+L+ ++ Sbjct: 653 DEPAI-ENINFEVKKGELAAIVGTVGSGKSSLLASV 687
>MRP14_ARATH (Q9LYS2) Multidrug resistance-associated protein 14 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 14) (ATP-energized glutathione S-conjugate pump 14) Length = 1389 Score = 215 bits (548), Expect = 8e-56 Identities = 105/213 (49%), Positives = 149/213 (69%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y T++EL R+ G T++ V +H E+V GA TIR F +E FF+++L I+++ +FH+ Sbjct: 982 YFQTAKELMRINGTTRSYVANHLAESVAGAITIRAFDEEERFFKKSLTLIDTNASPFFHS 1041 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +AANEWL RLE + +VL+ TAF MI LP+ F+GM+LSYGLSLN + +++ Sbjct: 1042 FAANEWLIQRLETVSAIVLASTAFCMILLPTGTFSSGFIGMALSYGLSLNMGLVYSVQNQ 1101 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C L N +++VER+NQ++ L EA E+ P NWP G ++ISDL++RYR +PL+LK Sbjct: 1102 CYLANWIISVERLNQYTHLTPEAPEVIEETRPPVNWPVTGRVEISDLQIRYRRESPLVLK 1161 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI+ + GG KIG+VGRTGSGK+TLI ALFRLV Sbjct: 1162 GISCTFEGGHKIGIVGRTGSGKTTLISALFRLV 1194 Score = 36.2 bits (82), Expect = 0.085 Identities = 14/31 (45%), Positives = 23/31 (74%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L+ +++ ++ GEK+ V G GSGKSTL+ A+ Sbjct: 556 LRNVSLEVKFGEKVAVCGEVGSGKSTLLAAI 586
>MRP3_ARATH (Q9LK64) Multidrug resistance-associated protein 3 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 3) (ATP-energized glutathione S-conjugate pump 3) Length = 1514 Score = 202 bits (515), Expect = 5e-52 Identities = 97/213 (45%), Positives = 146/213 (68%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A +REL+RL GV KAP+I HF+ET+ GATTIR F +E F +N+ + R F+ Sbjct: 1108 YIAAARELSRLVGVCKAPLIQHFSETISGATTIRSFSQEFRFRSDNMRLSDGYSRPKFYT 1167 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A EWL FRL+++ +L + ++S+P+ I G++++YGLSLN+L + I Sbjct: 1168 AGAMEWLCFRLDMLSSLTFVFSLVFLVSIPTGVIDPSLAGLAVTYGLSLNTLQAWLIWTL 1227 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C LEN +++VER+ Q++++PSE E + P +WP+ G+++I DL+VRY P+ PL+L+ Sbjct: 1228 CNLENKIISVERILQYASVPSEPPLVIESNRPEQSWPSRGEVEIRDLQVRYAPHMPLVLR 1287 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI + +GG + G+VGRTGSGKSTLIQ LFR+V Sbjct: 1288 GITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIV 1320
>MRP9_ARATH (Q9M1C7) Multidrug resistance-associated protein 9 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 9) (ATP-energized glutathione S-conjugate pump 9) Length = 1490 Score = 202 bits (514), Expect = 7e-52 Identities = 103/213 (48%), Positives = 136/213 (63%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y T+REL+R+ GV +AP++ HF E++ GATTIR F + + F NL I+S R +FH Sbjct: 1078 YTPTARELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFHV 1137 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +A EWL FRL L+ V + + L+++LP I G+ ++YGLSLN L I Sbjct: 1138 ASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNI 1197 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C EN M++VER+ Q+S +PSEA + H P NWP G I DL+VRY + P +LK Sbjct: 1198 CNAENKMISVERILQYSKIPSEAPLVIDGHRPLDNWPNVGSIVFRDLQVRYAEHFPAVLK 1257 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I GG+KIGVVGRTGSGKSTLIQALFR+V Sbjct: 1258 NITCEFPGGKKIGVVGRTGSGKSTLIQALFRIV 1290
>MRP15_ARATH (Q7FB56) Putative multidrug resistance-associated protein 15 (EC| 3.6.3.44) (Glutathione S-conjugate transporting ATPase 15) (ATP-energized glutathione S-conjugate pump 15) Length = 1037 Score = 200 bits (509), Expect = 3e-51 Identities = 103/213 (48%), Positives = 135/213 (63%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y T REL+R+ GV +AP++ HF E++ GATTIR F + + F NL I+S R +FH Sbjct: 625 YTPTERELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFHV 684 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +A EWL FRL L+ V + + L+++LP I G+ ++YGLSLN L I Sbjct: 685 ASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNI 744 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C EN M++VER+ Q S +PSEA +D P NWP G I DL+VRY + P +LK Sbjct: 745 CNAENKMISVERILQHSKIPSEAPLVIDDQRPLDNWPNVGSIVFRDLQVRYAEHFPAVLK 804 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I + GG+KIGVVGRTGSGKSTLIQALFR+V Sbjct: 805 NITCAFPGGKKIGVVGRTGSGKSTLIQALFRIV 837
>MRP6_ARATH (Q8LGU1) Multidrug resistance-associated protein 6 precursor (EC| 3.6.3.44) (Glutathione S-conjugate transporting ATPase 6) (ATP-energized glutathione S-conjugate pump 6) Length = 1295 Score = 194 bits (494), Expect = 1e-49 Identities = 96/213 (45%), Positives = 137/213 (64%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YLA++REL R+ G TKAPV+++ ET +G TIR F FF+ L+ +++ ++F + Sbjct: 884 YLASARELIRINGTTKAPVMNYAAETSLGVVTIRAFGTAERFFKNYLNLVDADAVLFFLS 943 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AA EW+ R+E + + L A L+I +P +I VG+SLSY L+L F Sbjct: 944 NAAMEWVILRIETLQNVTLFTCALLLILIPKGYIAPGLVGLSLSYALTLTQTQVFLTRWY 1003 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C L N +++VER+ Q+ +P E +D P +WP+NG I + +LK+RYRPN PL+LK Sbjct: 1004 CTLSNSIISVERIKQYMNIPEEPPAIIDDKRPPSSWPSNGTIHLQELKIRYRPNAPLVLK 1063 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI+ + R G ++GVVGRTGSGKSTLI ALFRLV Sbjct: 1064 GISCTFREGTRVGVVGRTGSGKSTLISALFRLV 1096 Score = 38.5 bits (88), Expect = 0.017 Identities = 38/151 (25%), Positives = 68/151 (45%), Gaps = 18/151 (11%) Frame = +2 Query: 233 LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAI----------------SIS 364 L + +FL P+ F+G +L LN+ F + +IS Sbjct: 342 LTKAFGSFLYWMSPTIVSSVVFLGCALLKSAPLNASTIFTVLATLRVMSEPVKIIPDAIS 401 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGD-IDISDLKVRYRPNTPL-I 538 +++ + V+ +R+N F L E K D + +G +DI + P T + Sbjct: 402 AIIQGN-VSFQRLNNF-LLDDEL---KMDEIERSGLDASGTAVDIQVGNFGWEPETKIPT 456 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L+ I++ I+ G+K+ V G G+GKS+L+ A+ Sbjct: 457 LRNIHLEIKHGQKVAVCGPVGAGKSSLLHAV 487
>MRP7_ARATH (Q9LK62) Multidrug resistance-associated protein 7 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 7) (ATP-energized glutathione S-conjugate pump 7) Length = 1493 Score = 192 bits (487), Expect = 9e-49 Identities = 94/214 (43%), Positives = 144/214 (67%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSL-RMYFH 181 Y++ +REL RL G++++P++ HF+ET+ G TTIR F +E F + ++ R+N R+ FH Sbjct: 1080 YISAARELARLSGISRSPLVQHFSETLSGITTIRSFDQEPRF-RTDIMRLNDCYSRLRFH 1138 Query: 182 NYAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 +A EWL FRL+L+ T+ +++ +++S+P I F G++++Y L+LNSL I Sbjct: 1139 AISAMEWLCFRLDLLSTVAFALSLVILVSVPEGVINPSFAGLAVTYALNLNSLQATLIWT 1198 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 C LEN M++VER+ Q+ +PSE E P +WP G+I I +L+VRY P+ P++L Sbjct: 1199 LCDLENKMISVERMLQYIDIPSEPSLVIESTRPEKSWPCRGEITICNLQVRYGPHLPMVL 1258 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +G+ + RGG K G+VGRTG GKSTLIQ LFR+V Sbjct: 1259 RGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIV 1292
>MRP5_ARATH (Q7GB25) Multidrug resistance-associated protein 5 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 5) (ATP-energized glutathione S-conjugate pump 5) Length = 1514 Score = 189 bits (481), Expect = 5e-48 Identities = 95/213 (44%), Positives = 138/213 (64%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SREL R+ + K+P+I F E++ GA TIR F +E F + NL ++ +R +F + Sbjct: 1107 YMASSRELVRIVSIQKSPIIHLFGESIAGAATIRGFGQEKRFIKRNLYLLDCFVRPFFCS 1166 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AA EWL R+EL+ TLV + L++S P I G++++YGL+LN + I Sbjct: 1167 IAAIEWLCLRMELLSTLVFAFCMVLLVSFPHGTIDPSMAGLAVTYGLNLNGRLSRWILSF 1226 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C LEN ++++ER+ Q+S + EA ED P +WP G I++ D+KVRY N P +L Sbjct: 1227 CKLENKIISIERIYQYSQIVGEAPAIIEDFRPPSSWPATGTIELVDVKVRYAENLPTVLH 1286 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 G++ GG+KIG+VGRTGSGKSTLIQALFRL+ Sbjct: 1287 GVSCVFPGGKKIGIVGRTGSGKSTLIQALFRLI 1319
>MRP8_ARATH (Q8VZZ4) Multidrug resistance-associated protein 8 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 8) (ATP-energized glutathione S-conjugate pump 8) Length = 1466 Score = 185 bits (470), Expect = 9e-47 Identities = 91/213 (42%), Positives = 137/213 (64%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y++ +REL RL G++++PV+ HF+ET+ G TTIR F +E F + + + R+ FH+ Sbjct: 1058 YISAARELARLAGISRSPVVHHFSETLSGITTIRSFDQEPRFRGDIMRLSDCYSRLKFHS 1117 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A EWL FRLEL+ T + + +++S P I G++++Y L+LN+L I Sbjct: 1118 TGAMEWLCFRLELLSTFAFASSLVILVSAPEGVINPSLAGLAITYALNLNTLQATLIWTL 1177 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 C LEN M++VER+ Q++ +PSE E P +WP+ G+I I +L+VRY P+ P++L Sbjct: 1178 CDLENKMISVERMLQYTNIPSEPPLVIETTRPEKSWPSRGEITICNLQVRYGPHLPMVLH 1237 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 G+ + GG K G+VGRTG GKSTLIQ LFR+V Sbjct: 1238 GLTCTFPGGLKTGIVGRTGCGKSTLIQTLFRIV 1270
>MRP1_CHICK (Q5F364) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1525 Score = 180 bits (457), Expect = 3e-45 Identities = 81/212 (38%), Positives = 137/212 (64%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ATSR+L RLE V+++PV HF ET++G + IR F+++ F ++N +++ + + Y+ + Sbjct: 1127 YVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDMKVDENQKAYYPS 1186 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AN WL RLE +G ++ A + + N + +G+S+SY L + + + + + ++ Sbjct: 1187 IVANRWLAVRLEFVGNCIVLFAALFAV-IARNKLSPGLIGLSVSYSLQITAYLNWLVRMT 1245 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 LE ++VAVERV +++ + EAEW E+ P+ WP G ++ +RYR + L+LK Sbjct: 1246 SDLETNIVAVERVKEYAEMEKEAEWSIEETAPASTWPQEGKVEFRGFGLRYREDLDLVLK 1305 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 IN++I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1306 NINITINGGEKVGIVGRTGAGKSSLTLGLFRI 1337 Score = 39.7 bits (91), Expect = 0.008 Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = +2 Query: 323 LSLNSLVYFAISISCMLENDMV-AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDIS 499 L+L +++ F ++I M+ + +V A + + S E + + P G I + Sbjct: 585 LALFNILRFPLNILPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITNAEGSIVVK 644 Query: 500 DLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + + P L IN ++ G I VVG+ G GKS+L+ AL Sbjct: 645 NATFSWSKTDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSAL 688
>YBT1_YEAST (P32386) ATP-dependent bile acid permease| Length = 1661 Score = 178 bits (451), Expect = 1e-44 Identities = 86/213 (40%), Positives = 136/213 (63%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A SREL R E ++++P+ HF+ET+VG TTIR F E F QENL +I+ + + +F+ Sbjct: 1222 YMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYL 1281 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + AN WL FR+++IG+LV+ A L I N + G+SL+Y +S + + + Sbjct: 1282 WVANRWLAFRIDMIGSLVI-FGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLY 1340 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 +E +M +VERV ++ + E + + +P P WP +G I+++DL +RY PN P ++K Sbjct: 1341 SEVEMNMNSVERVKEYMEIEQE-PYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIK 1399 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 ++ S+ KIG+VGRTG+GKST+I ALFR + Sbjct: 1400 NVSFSVDAQSKIGIVGRTGAGKSTIITALFRFL 1432 Score = 39.7 bits (91), Expect = 0.008 Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 16/155 (10%) Frame = +2 Query: 215 LELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYF-AISISCMLENDM-- 385 L L+ ++V SI++FL P+ F G L + V F A+S+ +L + + Sbjct: 593 LLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLRDPLDR 652 Query: 386 ------------VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRY-RPN 526 V+++RV F +E + KK D L P + + + + N Sbjct: 653 LSDMLSFVVQSKVSLDRVQDFL---NENDTKKYDQLTID--PNGNRFAFENSTISWDKDN 707 Query: 527 TPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 LK +N+ + G+ V+G TGSGK++L+ AL Sbjct: 708 QDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMAL 742
>YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium factor 1)| Length = 1515 Score = 175 bits (444), Expect = 9e-44 Identities = 85/214 (39%), Positives = 136/214 (63%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YL TSREL RL+ +T++P+ HF ET+ G T+R + ++ F N RI++++ ++ + Sbjct: 1110 YLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPS 1169 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMI-SLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 AN WL +RLELIG++++ A L + L + VG+SLSY L + + + + + Sbjct: 1170 INANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRM 1229 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 + +E ++V+VER+ +++ L SEA E H P WP+ GDI ++ RYRP L+L Sbjct: 1230 TVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDIKFNNYSTRYRPELDLVL 1289 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 K IN+ I+ EK+G+VGRTG+GKS+L ALFR++ Sbjct: 1290 KHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMI 1323 Score = 34.3 bits (77), Expect = 0.32 Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 6/109 (5%) Frame = +2 Query: 323 LSLNSLVYFAISISCMLENDMV-AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDI--- 490 L+L +L+ F + I M+ N + A + + T + E + + P GD+ Sbjct: 568 LTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAIN 627 Query: 491 --DISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 D + + +P + LK IN + G +VG+ GSGK+ L+ + Sbjct: 628 IGDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCM 676
>MRP1_RAT (Q8CG09) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1532 Score = 172 bits (437), Expect = 6e-43 Identities = 84/213 (39%), Positives = 139/213 (65%), Gaps = 1/213 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SR+L RLE V+++PV HF ET++G + IR F+++ F +++ +++ + + Y+ + Sbjct: 1134 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPS 1193 Query: 185 YAANEWLGFRLELIGT-LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 AN WL RLE +G +VL F +IS S + VG+S+SY L + + + + + + Sbjct: 1194 IVANRWLAVRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQITAYLNWLVRM 1251 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S +E ++VAVER+ ++S EA W+ ++ P WP +G ++ D +RYR + L+L Sbjct: 1252 SSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVL 1311 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 K INV+I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1312 KHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRI 1344 Score = 33.9 bits (76), Expect = 0.42 Identities = 17/48 (35%), Positives = 26/48 (54%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I + + + + P L GI +I G + VVG+ G GKS+L+ AL Sbjct: 645 ITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSAL 692
>MRP1_BOVIN (Q8HXQ5) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1530 Score = 172 bits (437), Expect = 6e-43 Identities = 85/213 (39%), Positives = 140/213 (65%), Gaps = 1/213 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SR+L RLE V+++PV HF ET++G + IR F+++ F +++ +++ + + Y+ + Sbjct: 1132 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPS 1191 Query: 185 YAANEWLGFRLELIGT-LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 AN WL RLE +G +VL + F +IS S + VG+S+SY L + + + + + + Sbjct: 1192 IVANRWLAVRLECVGNCIVLFASLFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRM 1249 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S +E ++VAVER+ ++S EA W+ +D P +WP G ++ D +RYR + L+L Sbjct: 1250 SSEMETNIVAVERLKEYSETEKEAPWQIQDMAPPKDWPQVGRVEFRDYGLRYREDLDLVL 1309 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 K INV+I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1310 KHINVTIDGGEKVGIVGRTGAGKSSLTLGLFRI 1342 Score = 37.0 bits (84), Expect = 0.050 Identities = 38/154 (24%), Positives = 69/154 (44%), Gaps = 15/154 (9%) Frame = +2 Query: 215 LELIGTLVLSITAFLM--------ISLPSNFI---KKEFVGMSLSYGLSLNSLVYFAISI 361 L +GT T FL+ +++ N I +K FV L+L +++ F ++I Sbjct: 545 LAAVGTFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVS------LALFNILRFPLNI 598 Query: 362 SCMLENDMV----AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNT 529 M+ + +V +++R+ F + + + P + I + + + N Sbjct: 599 LPMVISSIVQASVSLKRLRVFLS-HEDLDPDSIQRRPIKDAGATNSITVKNATFTWARND 657 Query: 530 PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 P L GI S+ G + VVG+ G GKS+L+ AL Sbjct: 658 PPTLHGITFSVPEGSLVAVVGQVGCGKSSLLSAL 691
>MRP1_CANFA (Q6UR05) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1531 Score = 172 bits (436), Expect = 8e-43 Identities = 79/212 (37%), Positives = 136/212 (64%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SR+L RLE V+++PV HF ET++G + IR F+++ F +++ +++ + + Y+ + Sbjct: 1133 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPS 1192 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AN WL RLE +G ++ A + + + + VG+S+SY L + + + + + +S Sbjct: 1193 IVANRWLAVRLECVGNCIVLFAALFSV-ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMS 1251 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 +E ++VAVER+ ++S EA W+ ++ P WP G ++ D +RYR N L+LK Sbjct: 1252 SEMETNIVAVERLKEYSETEKEAPWQIQEMAPPSTWPQVGRVEFRDYGLRYRENLDLVLK 1311 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 IN++I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1312 HINITINGGEKVGIVGRTGAGKSSLTLGLFRI 1343 Score = 37.4 bits (85), Expect = 0.038 Identities = 40/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%) Frame = +2 Query: 215 LELIGTLVLSITAFLM--------ISLPSNFI---KKEFVGMSLSYGLSLNSLVYFAISI 361 L +GT T FL+ +++ N I +K FV L+L +++ F ++I Sbjct: 545 LAAVGTFTWVCTPFLVALSTFAVYVTVDKNNILDAQKAFVS------LALFNILRFPLNI 598 Query: 362 SCMLENDMV----AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNT 529 M+ + +V +++R+ F + E E + P + I + + + + Sbjct: 599 LPMVISSIVQASVSLKRLRIFLS-HEELEPDSIERRPVKDGGGANSITVKNATFTWARSD 657 Query: 530 PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 P L GI SI G + VVG+ G GKS+L+ AL Sbjct: 658 PPTLSGITFSIPEGSLVAVVGQVGCGKSSLLSAL 691
>MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1528 Score = 172 bits (435), Expect = 1e-42 Identities = 84/213 (39%), Positives = 138/213 (64%), Gaps = 1/213 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SR+L RLE V+++PV HF ET++G + IR F+++ F ++ +++ + + Y+ + Sbjct: 1130 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1189 Query: 185 YAANEWLGFRLELIGT-LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 AN WL RLE +G +VL F +IS S + VG+S+SY L + + + + + + Sbjct: 1190 IVANRWLAVRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQITAYLNWLVRM 1247 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S +E ++VAVER+ ++S EA W+ ++ P WP +G ++ D +RYR + L+L Sbjct: 1248 SSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVL 1307 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 K INV+I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1308 KHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRI 1340 Score = 34.3 bits (77), Expect = 0.32 Identities = 18/48 (37%), Positives = 25/48 (52%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I + + + P L GI SI G + VVG+ G GKS+L+ AL Sbjct: 644 ITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSAL 691
>YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c| Length = 1478 Score = 171 bits (432), Expect = 2e-42 Identities = 91/214 (42%), Positives = 135/214 (63%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y TSREL RL+ VT++P+ HF E++ G +TIR + E+ F EN R++++ R++F Sbjct: 1077 YTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLY 1136 Query: 185 YAANEWLGFRLELIGTLVLSITAFL-MISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 +++N W R+E IG LV+ +AF ++S VG+SLSY + + + F + Sbjct: 1137 FSSNRWQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTFVVRQ 1196 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S +E ++V+VER+ ++ LPSEA DH P WP++G I VRYR N PL+L Sbjct: 1197 SVDVETNIVSVERMLEYIGLPSEAPSIIPDHRPPEGWPSHGAIKFDHYSVRYRENLPLVL 1256 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+V+I+ EKIG+VGRTG+GKSTL ALFRL+ Sbjct: 1257 NDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLI 1290 Score = 35.0 bits (79), Expect = 0.19 Identities = 49/193 (25%), Positives = 81/193 (41%), Gaps = 8/193 (4%) Frame = +2 Query: 74 TETVVGATTIRCFKKENEFFQENLDRINS-SLRMYFHNYAANEWLGFRLELIGTLVLSIT 250 TE + +I+ + EN F Q+ L N+ LRM N F LV + T Sbjct: 453 TEIINNIRSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSAAT 512 Query: 251 --AFLMISLPSNFIKKEFVGMSLS-YGLSLNSLVYFAISISCMLENDMVAVERVNQFSTL 421 F+++ + + + V LS + L L I +S +LE VA+ R+ F T Sbjct: 513 FGTFIVLYGKTRVLSVDIVFACLSLFNLLQFPLTMLPIVVSSVLEAS-VAISRIYGFLTA 571 Query: 422 PSEAEWKKEDHLPSPNWPTNGDIDISDLKVRY----RPNTPLILKGINVSIRGGEKIGVV 589 E + P+ P+ ++I + + L+ I+ R GE +V Sbjct: 572 -GELDSNAVQRYPANKEPSGVCLEIKKGTFSWSGPGQNAAEPTLRDIDFVARRGELCCIV 630 Query: 590 GRTGSGKSTLIQA 628 G+ G GKS+L++A Sbjct: 631 GKVGMGKSSLLEA 643
>MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion transporter 1| (ATP-binding cassette sub-family C member 2) Length = 1543 Score = 170 bits (430), Expect = 4e-42 Identities = 84/213 (39%), Positives = 136/213 (63%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ATSR+L RL+ VTK+P+ HF+ETV G IR F+ + F + +I+++ + F Sbjct: 1139 YVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSW 1198 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +N WL RLEL+G L++ +A L++ + N + + VG LS L++ + + + ++ Sbjct: 1199 ITSNRWLAIRLELVGNLIVFCSALLLV-IYKNSLTGDTVGFVLSNALNITQTLNWLVRMT 1257 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 +E ++VAVER+N++ + +EA W D P +WP G+I ++ +VRYRP L+LK Sbjct: 1258 SEVETNIVAVERINEYINVDNEAPW-VTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLK 1316 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI +I+ EK+GVVGRTG+GKS+L LFR++ Sbjct: 1317 GITCNIKSTEKVGVVGRTGAGKSSLTNCLFRIL 1349 Score = 35.8 bits (81), Expect = 0.11 Identities = 43/196 (21%), Positives = 83/196 (42%), Gaps = 11/196 (5%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSITAF 256 E + G ++ F E F ++ LR L F L L TLV IT Sbjct: 502 EILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFS 561 Query: 257 LMISLPSNFI---KKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQF----- 412 + + + S + +K F ++L + + L + IS +++ V+V+R+ ++ Sbjct: 562 VYVLVDSQNVLNAEKAFTSITL-FNILRFPLAMLPMVISSVIQAS-VSVDRLERYLGSDD 619 Query: 413 ---STLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIG 583 S + + K ++ + D++ + ++ +N+ I+ G+ + Sbjct: 620 LDLSAIRHVCHFDKAVQFSEASFTWDRDLEAT-------------IQDVNLDIKPGQLVA 666 Query: 584 VVGRTGSGKSTLIQAL 631 VVG GSGKS+LI A+ Sbjct: 667 VVGTVGSGKSSLISAM 682
>MRP2_RAT (Q63120) Canalicular multispecific organic anion transporter 1| (ATP-binding cassette sub-family C member 2) (Multidrug resistance-associated protein 2) (Canalicular multidrug resistance protein) Length = 1541 Score = 169 bits (427), Expect = 8e-42 Identities = 85/213 (39%), Positives = 135/213 (63%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ATSR+L RL+ VTK+P+ HF+ETV G IR F+ + F N +I+ + + F Sbjct: 1137 YVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSW 1196 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +N WL RLEL+G LV+ +A L++ + + + VG LS L++ + + + ++ Sbjct: 1197 ITSNRWLAIRLELVGNLVVFCSALLLV-IYRKTLTGDVVGFVLSNALNITQTLNWLVRMT 1255 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 E ++VAVER++++ + +EA W D P +WP +G+I ++ +VRYRP L+LK Sbjct: 1256 SEAETNIVAVERISEYINVENEAPWVT-DKRPPADWPRHGEIQFNNYQVRYRPELDLVLK 1314 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI +I+ GEK+GVVGRTG+GKS+L LFR++ Sbjct: 1315 GITCNIKSGEKVGVVGRTGAGKSSLTNCLFRIL 1347 Score = 37.7 bits (86), Expect = 0.029 Identities = 15/48 (31%), Positives = 29/48 (60%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + S+ + P+ ++ +N+ I+ G+ + VVG GSGKS+L+ A+ Sbjct: 633 VKFSEASFTWDPDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAM 680
>MRP2_RABIT (Q28689) Canalicular multispecific organic anion transporter 1| (ATP-binding cassette sub-family C member 2) (Multidrug resistance-associated protein 2) (Canalicular multidrug resistance protein) (Epithelial basolateral chloride conductance reg Length = 1564 Score = 169 bits (427), Expect = 8e-42 Identities = 87/213 (40%), Positives = 134/213 (62%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ATSR+L RL+ VT++P+ HFTETV G IR F+ + F ++N I+++ + Sbjct: 1139 YVATSRQLRRLDSVTRSPIYSHFTETVSGLPVIRAFEHQQRFLKQNEIGIDTNQKCVSSW 1198 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +N WL FRLEL+G LV+ +A +M+ + + + + VG LS L++ + + + ++ Sbjct: 1199 ITSNRWLAFRLELVGNLVVFSSALMMV-IYRDTLSGDVVGFVLSNALNITQTLNWLVRMT 1257 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 E ++VAVER+ ++ + +EA W D P WP G+I S+ +VRYRP L+LK Sbjct: 1258 SETETNIVAVERITEYIKVENEAPW-VTDKRPPAGWPHKGEIQFSNYQVRYRPELDLVLK 1316 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GIN I+ EKIGVVGRTG+GKS+L LFR++ Sbjct: 1317 GINCDIKSMEKIGVVGRTGAGKSSLTNCLFRIL 1349 Score = 35.0 bits (79), Expect = 0.19 Identities = 38/147 (25%), Positives = 70/147 (47%), Gaps = 6/147 (4%) Frame = +2 Query: 209 FRLELIGTLVLSITAFLMISLPSNFI---KKEFVGMSLSYGLSLNSLVYFAISISCMLEN 379 F L L LV T + + + SN I +K F ++L + + + IS ML+ Sbjct: 546 FLLYLTPVLVSVTTFSVYVLVDSNNILDAEKAFTSITL-FNILRFPMSMLPNVISAMLQA 604 Query: 380 DMVAVERVNQFST---LPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGI 550 V+V+R+ ++ + L + A + PN+ + + S+ + N ++ + Sbjct: 605 S-VSVDRLEKYLSGDDLDTSAIQR------DPNF--DKAVQFSEASFTWDRNLEPTIRNV 655 Query: 551 NVSIRGGEKIGVVGRTGSGKSTLIQAL 631 N+ I G+ + VVG GSGKS+L+ A+ Sbjct: 656 NLDIMPGQLVAVVGTVGSGKSSLMSAM 682
>MRP1_MACFA (Q864R9) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1531 Score = 168 bits (425), Expect = 1e-41 Identities = 82/213 (38%), Positives = 137/213 (64%), Gaps = 1/213 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SR+L RLE V+++PV HF ET++G + IR F+++ F ++ +++ + + Y+ + Sbjct: 1133 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1192 Query: 185 YAANEWLGFRLELIGT-LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 AN WL RLE +G +VL F +IS S + VG+S+SY L + + + + + + Sbjct: 1193 IVANRWLAVRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRM 1250 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S +E ++VAVER+ ++S EA W+ ++ P NWP G ++ + +RYR + +L Sbjct: 1251 SSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSNWPQVGRVEFRNYCLRYREDLDFVL 1310 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 + INV+I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1311 RHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1343 Score = 37.7 bits (86), Expect = 0.029 Identities = 39/154 (25%), Positives = 70/154 (45%), Gaps = 15/154 (9%) Frame = +2 Query: 215 LELIGTLVLSITAFLM--------ISLPSNFI---KKEFVGMSLSYGLSLNSLVYFAISI 361 L +GT T FL+ +++ N + +K FV L+L +++ F ++I Sbjct: 545 LAAVGTFTWVCTPFLVALCTFAVYVTIDKNNVLDAQKAFVS------LALFNILRFPLNI 598 Query: 362 SCMLENDMV----AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNT 529 M+ + +V +++R+ F + E E + P + I + + + + Sbjct: 599 LPMVISSIVQASVSLKRLRIFLS-HEELEPDSIERRPVKDGGDTNSITVRNATFTWARSD 657 Query: 530 PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 P L GI SI G + VVG+ G GKS+L+ AL Sbjct: 658 PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSAL 691
>MRP2_HUMAN (Q92887) Canalicular multispecific organic anion transporter 1| (ATP-binding cassette sub-family C member 2) (Multidrug resistance-associated protein 2) (Canalicular multidrug resistance protein) Length = 1545 Score = 167 bits (423), Expect = 2e-41 Identities = 83/213 (38%), Positives = 135/213 (63%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y++TSR+L RL+ VT++P+ HF+ETV G IR F+ + F + N RI+++ + F Sbjct: 1141 YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW 1200 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +N WL RLEL+G L + +A +M+ + + + + VG LS L++ + + + ++ Sbjct: 1201 ITSNRWLAIRLELVGNLTVFFSALMMV-IYRDTLSGDTVGFVLSNALNITQTLNWLVRMT 1259 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 +E ++VAVER+ +++ + +EA W D P P+WP+ G I ++ +VRYRP L+L+ Sbjct: 1260 SEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLR 1318 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 GI I EKIGVVGRTG+GKS+L LFR++ Sbjct: 1319 GITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351 Score = 36.2 bits (82), Expect = 0.085 Identities = 35/152 (23%), Positives = 68/152 (44%), Gaps = 11/152 (7%) Frame = +2 Query: 209 FRLELIGTLVLSITAFLMISLPSNFI---KKEFVGMSLSYGLSLNSLVYFAISISCMLEN 379 F +L LV +T + + + SN I +K F ++L + + L + IS ML+ Sbjct: 548 FVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITL-FNILRFPLSMLPMMISSMLQA 606 Query: 380 DMVAVERVNQF--------STLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL 535 V+ ER+ ++ S + + + K + S+ + ++ Sbjct: 607 S-VSTERLEKYLGGDDLDTSAIRHDCNFDKA-------------MQFSEASFTWEHDSEA 652 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++ +N+ I G+ + V+G GSGKS+LI A+ Sbjct: 653 TVRDVNLDIMAGQLVAVIGPVGSGKSSLISAM 684
>MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1 (ATP-binding| cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Length = 1531 Score = 166 bits (420), Expect = 5e-41 Identities = 81/213 (38%), Positives = 137/213 (64%), Gaps = 1/213 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+A+SR+L RLE V+++PV HF ET++G + IR F+++ F ++ +++ + + Y+ + Sbjct: 1133 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1192 Query: 185 YAANEWLGFRLELIGT-LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 AN WL RLE +G +VL F +IS S + VG+S+SY L + + + + + + Sbjct: 1193 IVANRWLAVRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRM 1250 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S +E ++VAVER+ ++S EA W+ ++ P +WP G ++ + +RYR + +L Sbjct: 1251 SSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVL 1310 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 + INV+I GGEK+G+VGRTG+GKS+L LFR+ Sbjct: 1311 RHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1343 Score = 36.6 bits (83), Expect = 0.065 Identities = 29/107 (27%), Positives = 53/107 (49%), Gaps = 4/107 (3%) Frame = +2 Query: 323 LSLNSLVYFAISISCMLENDMV----AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDI 490 L+L +++ F ++I M+ + +V +++R+ F + E E + P + I Sbjct: 586 LALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS-HEELEPDSIERRPVKDGGGTNSI 644 Query: 491 DISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + + + + P L GI SI G + VVG+ G GKS+L+ AL Sbjct: 645 TVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSAL 691
>MRP3_RAT (O88563) Canalicular multispecific organic anion transporter 2| (Multidrug resistance-associated protein 3) (MRP-like protein 2) (MLP-2) Length = 1522 Score = 160 bits (406), Expect = 2e-39 Identities = 77/213 (36%), Positives = 132/213 (61%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ATSR+L RLE V+++P+ HF+ETV G + IR + + +F + +++S+ + + Sbjct: 1124 YVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPY 1183 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A+N WLG +E +G V+ +A + + N + VG+S+SY L + + + I Sbjct: 1184 IASNRWLGVHVEFVGNCVVLFSALFAV-IGRNSLNPGLVGLSVSYALQVTLSLNWMIRTL 1242 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 LE++++AVERV ++S +EA W E + WP +G ++ + VRYRP L+LK Sbjct: 1243 SDLESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGVVEFRNYSVRYRPGLELVLK 1302 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + ++GGEK+G+VGRTG+GKS++ LFR++ Sbjct: 1303 NLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRIL 1335 Score = 33.1 bits (74), Expect = 0.72 Identities = 32/131 (24%), Positives = 55/131 (41%) Frame = +2 Query: 239 LSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFST 418 +S++ F ++ +P N + + GM+ + +SL + F L D + + V + + Sbjct: 568 VSLSLFNILKIPLNLLPQLISGMTQT-SVSLKRIQDF-------LNQDELDPQCVERKTI 619 Query: 419 LPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRT 598 P A I I + + + P L IN+ I G + VVG Sbjct: 620 SPGRA------------------ITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVVGPV 661 Query: 599 GSGKSTLIQAL 631 G GKS+L+ AL Sbjct: 662 GCGKSSLVSAL 672
>MRP3_HUMAN (O15438) Canalicular multispecific organic anion transporter 2| (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D) Length = 1527 Score = 159 bits (403), Expect = 5e-39 Identities = 76/213 (35%), Positives = 130/213 (61%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y ATSR+L RLE V+++P+ HF+ETV GA+ IR + + +F + +++++ R + Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +N WL +E +G V+ A + + + + VG+S+SY L + + + I + Sbjct: 1189 IISNRWLSIGVEFVGNCVVLFAALFAV-IGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM 1247 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 LE+++VAVERV ++S +EA W E P WP G+++ + VRYRP L+L+ Sbjct: 1248 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR 1307 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +++ + GGEK+G+VGRTG+GKS++ LFR++ Sbjct: 1308 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRIL 1340 Score = 35.0 bits (79), Expect = 0.19 Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 5/138 (3%) Frame = +2 Query: 233 LVLSITAFLMISLPSNFI---KKEFVGMSLS--YGLSLNSLVYFAISISCMLENDMVAVE 397 LV IT ++ + + N + +K FV +SL L LN L +++ V+++ Sbjct: 545 LVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT----QASVSLK 600 Query: 398 RVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEK 577 R+ QF + E SP + I I + + P L +++ + G Sbjct: 601 RIQQFLSQEELDPQSVERKTISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGAL 656 Query: 578 IGVVGRTGSGKSTLIQAL 631 + VVG G GKS+L+ AL Sbjct: 657 VAVVGPVGCGKSSLVSAL 674
>YHD5_YEAST (P38735) Probable ATP-dependent permease YHL035C| Length = 1592 Score = 159 bits (401), Expect = 9e-39 Identities = 79/218 (36%), Positives = 136/218 (62%), Gaps = 5/218 (2%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YL SREL RL+ +TK+P+ HF+ET+VG TIR F E F EN+++I+ + R +F+ Sbjct: 1159 YLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYL 1218 Query: 185 YAANEWLGFRLELIGT-LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 +W FR+++IG +VL+ +F+++++ + I G+SL+Y + + + + Sbjct: 1219 SVTVKWFSFRVDMIGAFIVLASGSFILLNIAN--IDSGLAGISLTYAILFTDGALWLVRL 1276 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDH----LPSPNWPTNGDIDISDLKVRYRPNT 529 E +M +VER+ ++S++ E ++ L P+WP +G+I+I +L +RY PN Sbjct: 1277 YSTFEMNMNSVERLKEYSSIEQENYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNL 1336 Query: 530 PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 P +++ ++ + KIG+VGRTG+GKST+I ALFRL+ Sbjct: 1337 PPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLL 1374 Score = 33.5 bits (75), Expect = 0.55 Identities = 37/153 (24%), Positives = 70/153 (45%), Gaps = 19/153 (12%) Frame = +2 Query: 230 TLVLSITAFLMISLPS----------NFIKKEFVGMSLSYG-LSLNSLVYFAIS-ISCML 373 +LV S+T+FL P+ F++ E + L++ LSL +L+ + +S ML Sbjct: 568 SLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAPLAFTTLSLFTLLKTPLDQLSNML 627 Query: 374 E---NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPN----TP 532 V+++R++ F + ++ + P N I+ + + + N Sbjct: 628 SFINQSKVSLKRISDFLRMDDTEKYNQLTISPDKN-----KIEFKNATLTWNENDSDMNA 682 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L G+N+ + G+ ++G TGSGKS L+ L Sbjct: 683 FKLCGLNIKFQIGKLNLILGSTGSGKSALLLGL 715
>MRP1_ARATH (Q9C8G9) Multidrug resistance-associated protein 1 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 1) (ATP-energized glutathione S-conjugate pump 1) Length = 1622 Score = 157 bits (398), Expect = 2e-38 Identities = 81/217 (37%), Positives = 133/217 (61%), Gaps = 4/217 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y TSRE+ R++ T++PV F E + G ++IR +K + + N +++++R N Sbjct: 1072 YQNTSREIKRMDSTTRSPVYAQFGEALNGLSSIRAYKAYDRMAEINGRSMDNNIRFTLVN 1131 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEF----VGMSLSYGLSLNSLVYFA 352 AAN WLG RLE++G L++ +TA L + ++ +G+ LSY LS+ S + Sbjct: 1132 MAANRWLGIRLEVLGGLMVWLTASLAVMQNGKAANQQAYASTMGLLLSYALSITSSLTAV 1191 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTP 532 + ++ + EN + +VERV + +PSEA E++ P P WP++G I D+ +RYRP P Sbjct: 1192 LRLASLAENSLNSVERVGNYIEIPSEAPLVIENNRPPPGWPSSGSIKFEDVVLRYRPELP 1251 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +L G++ I +K+G+VGRTG+GKS+L+ ALFR+V Sbjct: 1252 PVLHGVSFLISPMDKVGIVGRTGAGKSSLLNALFRIV 1288 Score = 38.9 bits (89), Expect = 0.013 Identities = 47/216 (21%), Positives = 94/216 (43%), Gaps = 8/216 (3%) Frame = +2 Query: 8 LATSRELTRLEGVTKAPV-IDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 ++ +++LT+ EG+ + I E + T++C+ EN F Q + + +F Sbjct: 460 ISKTQKLTK-EGLQRTDKRIGLMNEVLAAMDTVKCYAWENSF-QSKVQTVRDDELSWFRK 517 Query: 185 YAANEWLGFRLELIGTL--VLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAIS 358 A F + ++ ++ ++++ +F + SL + SLS L ++ + Sbjct: 518 --AQLLSAFNMFILNSIPVLVTVVSFGVFSLLGGDLTPARAFTSLSLFSVLRFPLFMLPN 575 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRY-----RP 523 I + N V++ R+ + + E+ + PN P ++ Y + Sbjct: 576 IITQMVNANVSLNRLEEVLST--------EERVLLPNPPIEPGQPAISIRNGYFSWDSKA 627 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + P L IN+ I G + VVG TG GK++LI A+ Sbjct: 628 DRPT-LSNINLDIPLGSLVAVVGSTGEGKTSLISAM 662
>MRP2_ARATH (Q42093) Multidrug resistance-associated protein 2 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 2) (ATP-energized glutathione S-conjugate pump 2) Length = 1623 Score = 152 bits (384), Expect = 8e-37 Identities = 78/217 (35%), Positives = 130/217 (59%), Gaps = 4/217 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y T+RE+ R++ ++++PV F E + G +TIR +K + N +++++R N Sbjct: 1077 YQNTAREVKRMDSISRSPVYAQFGEALNGLSTIRAYKAYDRMADINGRSMDNNIRFTLVN 1136 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEF----VGMSLSYGLSLNSLVYFA 352 AN WLG RLE +G L++ +TA + ++ +G+ LSY L++ SL+ Sbjct: 1137 MGANRWLGIRLETLGGLMIWLTASFAVMQNGRAENQQAFASTMGLLLSYALNITSLLTGV 1196 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTP 532 + ++ + EN + AVERV + +P EA E++ P P WP++G I D+ +RYRP P Sbjct: 1197 LRLASLAENSLNAVERVGNYIEIPPEAPPVIENNRPPPGWPSSGSIKFEDVVLRYRPQLP 1256 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +L G++ I +K+G+VGRTG+GKS+L+ ALFR+V Sbjct: 1257 PVLHGVSFFIHPTDKVGIVGRTGAGKSSLLNALFRIV 1293 Score = 37.0 bits (84), Expect = 0.050 Identities = 47/197 (23%), Positives = 80/197 (40%), Gaps = 12/197 (6%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLG----FRLELIGTLVLS 244 E + T++C+ EN F Q + + +F ++ LG F L I LV + Sbjct: 483 EVLAAMDTVKCYAWENSF-QSKVQTVRDDELSWFRK---SQLLGALNMFILNSIPVLV-T 537 Query: 245 ITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLP 424 I +F + +L + SLS L ++ +I + N V+++R+ + Sbjct: 538 IVSFGVFTLLGGDLTPARAFTSLSLFAVLRFPLFMLPNIITQVVNANVSLKRLEEVLAT- 596 Query: 425 SEAEWKKEDHLPSPNWPTNGDIDISDLKVRY--------RPNTPLILKGINVSIRGGEKI 580 E+ + PN P ++ Y RP L IN+ + G + Sbjct: 597 -------EERILLPNPPIEPGEPAISIRNGYFSWDSKGDRPT----LSNINLDVPLGSLV 645 Query: 581 GVVGRTGSGKSTLIQAL 631 VVG TG GK++LI A+ Sbjct: 646 AVVGSTGEGKTSLISAI 662
>MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5 (Multi-specific| organic anion transporter-C) (MOAT-C) (pABC11) (SMRP) Length = 1437 Score = 150 bits (380), Expect = 2e-36 Identities = 79/209 (37%), Positives = 123/209 (58%), Gaps = 1/209 (0%) Frame = +2 Query: 20 RELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANE 199 REL RL+ +T++P + H T ++ G TI + K EF + ++ + +F A Sbjct: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMR 1096 Query: 200 WLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLEN 379 WL RL+LI +++ T LMI L I + G+++SY + L L F + ++ E Sbjct: 1097 WLAVRLDLISIALITTTG-LMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEA 1155 Query: 380 DMVAVERVNQF-STLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 +VER+N + TL EA + ++ PSP+WP G++ + ++RYR N PL+LK ++ Sbjct: 1156 RFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSF 1215 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +I+ EKIG+VGRTGSGKS+L ALFRLV Sbjct: 1216 TIKPKEKIGIVGRTGSGKSSLGMALFRLV 1244 Score = 33.9 bits (76), Expect = 0.42 Identities = 19/61 (31%), Positives = 32/61 (52%) Frame = +2 Query: 449 DHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQA 628 D PSP I + L+++ L I++ I+ G+ +G+ G GSGK++LI A Sbjct: 554 DERPSPEEEEGKHIHLGHLRLQRT------LHSIDLEIQEGKLVGICGSVGSGKTSLISA 607 Query: 629 L 631 + Sbjct: 608 I 608
>YH85_SCHPO (Q9P5N0) Probable ATP-dependent permease C359.05| Length = 1465 Score = 150 bits (379), Expect = 3e-36 Identities = 80/214 (37%), Positives = 127/214 (59%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ TSREL RL+ VT++P+ H E++ G +TIR + + F +EN RI+++ R++F Sbjct: 1064 YVRTSRELKRLDNVTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMF 1123 Query: 185 YAANEWLGFRLELIGTLVLSITAFL-MISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISI 361 ++++ W R+E IG L++ TAF ++S VG SLSY + + + F + Sbjct: 1124 FSSSRWQAIRVECIGDLIIFCTAFYGILSAIKGSPNPGLVGFSLSYAIQITQGLSFIVQQ 1183 Query: 362 SCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 S EN+ V+VER+ ++ + SEA ++ P WPT+G + + +YR + L Sbjct: 1184 SVDAENNTVSVERILEYINVKSEAPEIIPENRPPCEWPTDGAVSFNHYSAKYREDLSFAL 1243 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 IN+ I EKIG+VGRTG+GKSTL ALFR++ Sbjct: 1244 NNINIEISPREKIGIVGRTGAGKSTLAMALFRII 1277
>MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5| Length = 1436 Score = 147 bits (370), Expect = 3e-35 Identities = 78/209 (37%), Positives = 121/209 (57%), Gaps = 1/209 (0%) Frame = +2 Query: 20 RELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANE 199 REL RL+ +T++P + H T ++ G TI + K EF + ++ + +F A Sbjct: 1036 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMR 1095 Query: 200 WLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLEN 379 WL RL+LI +++ T LMI L I + G+++SY + L L F + ++ E Sbjct: 1096 WLAVRLDLISIALITTTG-LMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEA 1154 Query: 380 DMVAVERVNQF-STLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 +VER+N + TL EA + ++ P +WP G+I + ++RYR N PL+LK ++ Sbjct: 1155 RFTSVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSF 1214 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +I+ EKIG+VGRTGSGKS+L ALFRLV Sbjct: 1215 TIKPKEKIGIVGRTGSGKSSLGMALFRLV 1243 Score = 32.0 bits (71), Expect = 1.6 Identities = 18/61 (29%), Positives = 30/61 (49%) Frame = +2 Query: 449 DHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQA 628 D PSP I ++++ L I++ I G+ +G+ G GSGK++LI A Sbjct: 554 DERPSPEEEEGKQIHAGSMRLQRT------LYNIDLEIEEGKLVGICGSVGSGKTSLISA 607 Query: 629 L 631 + Sbjct: 608 I 608
>MRP13_ARATH (Q9C8H0) Multidrug resistance-associated protein 13 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 13) (ATP-energized glutathione S-conjugate pump 13) Length = 1495 Score = 145 bits (366), Expect = 1e-34 Identities = 78/217 (35%), Positives = 128/217 (58%), Gaps = 4/217 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y +TSRE+ RL+ VT++P+ F E + G ++IR +K + + N +++++R N Sbjct: 1070 YQSTSREVRRLDSVTRSPIYAQFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTLAN 1129 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKK----EFVGMSLSYGLSLNSLVYFA 352 ++N WL RLE +G +++ +TA + N + +G+ LSY L++ SL+ Sbjct: 1130 TSSNRWLTIRLETLGGVMIWLTATFAVLQNGNTNNQAGFASTMGLLLSYTLNITSLLSGV 1189 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTP 532 + + EN + +VERV + LPSEA E++ P WP+ G I D+ +RYRP P Sbjct: 1190 LRQASRAENSLNSVERVGNYIDLPSEATDIIENNRPVCGWPSGGSIKFEDVHLRYRPGLP 1249 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +L G+ + EK+GVVGRTG+GKS+++ ALFR+V Sbjct: 1250 PVLHGLTFFVSPSEKVGVVGRTGAGKSSMLNALFRIV 1286 Score = 33.5 bits (75), Expect = 0.55 Identities = 40/189 (21%), Positives = 73/189 (38%), Gaps = 4/189 (2%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSITAF 256 E + T++C+ E F N L + + + F L I +V+++ +F Sbjct: 484 EILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFNSFILNSI-PVVVTVVSF 542 Query: 257 LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEAE 436 + L + SLS L + ++ + N V+++R+ + Sbjct: 543 GVFVLLGGDLTPARAFTSLSLFAVLRFPLNMLPNLLSQVVNANVSLQRIEELLL------ 596 Query: 437 WKKEDHLPSPNWPTNGDIDISDLKVRY----RPNTPLILKGINVSIRGGEKIGVVGRTGS 604 E+ + + N P +K Y T L IN+ I G + +VG TG Sbjct: 597 --SEERILAQNPPLQPGTPAISIKNGYFSWDSKTTKPTLSDINLEIPVGTLVAIVGGTGE 654 Query: 605 GKSTLIQAL 631 GK++LI A+ Sbjct: 655 GKTSLISAM 663
>NFT1_YEAST (P36028) ABC transporter NFT1 (New full-length MRP-type transporter| 1) Length = 1558 Score = 144 bits (363), Expect = 2e-34 Identities = 72/212 (33%), Positives = 125/212 (58%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YL SREL R++ + +P+ F E + G TTIR E F ++L I+ S +F+ Sbjct: 1128 YLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSNAPFFYL 1187 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A EW+ +R+++IGTLVL ++ +MI + ++++ G+ LS S + I + Sbjct: 1188 NMATEWITYRVDIIGTLVL-FSSSVMIIMKASYLDAGLAGILLSNAFSFTETAQWIIKVF 1246 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 +E M +VER+ +++ +PSE+ P NWP GD+++ +L +RY P++ L Sbjct: 1247 SSVELLMSSVERIKEYTDIPSESNGYIS---PPANWPQTGDVELKNLSLRYSPHSSKALD 1303 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 ++ ++ G K+G+VGRTG+GKS++I A++RL Sbjct: 1304 NVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRL 1335 Score = 38.5 bits (88), Expect = 0.017 Identities = 42/188 (22%), Positives = 81/188 (43%), Gaps = 2/188 (1%) Frame = +2 Query: 74 TETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIG-TLVLSIT 250 +E + I+ EN F+Q+ ++ + +R+ A +L + G TLV +IT Sbjct: 520 SEALNSIRVIKLLAWENLFYQKIINVRDGEIRL-LKKKATIFFLNHLIWFFGPTLVSAIT 578 Query: 251 AFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSE 430 + I + + +LS L + + S +L +++ER+ + +E Sbjct: 579 FSVFIKFQNQTLTPTIAFTALSLFAILRTPMDQIASTVSLLIQSFISLERIQDYL---NE 635 Query: 431 AEWKKEDHLPSPNWPTNGDIDISDLKVRYRP-NTPLILKGINVSIRGGEKIGVVGRTGSG 607 +E +K + L +N D + + T LK I++ + ++G TGSG Sbjct: 636 SETRKYEILEQ----SNTKFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSG 691 Query: 608 KSTLIQAL 631 KS+L+ L Sbjct: 692 KSSLLLGL 699
>MRP6_HUMAN (O95255) Multidrug resistance-associated protein 6 (ATP-binding| cassette sub-family C member 6) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter-E) (MOAT-E) Length = 1503 Score = 143 bits (361), Expect = 4e-34 Identities = 74/212 (34%), Positives = 115/212 (54%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ +S +L RLE + + V H ET G+T +R F+ + F +N R++ S R+ F Sbjct: 1105 YVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPR 1164 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A+ WL +EL+G ++ A + L + VG S+S L + + + + Sbjct: 1165 LVADRWLAANVELLGNGLVFAAATCAV-LSKAHLSAGLVGFSVSAALQVTQTLQWVVRNW 1223 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 LEN +V+VER+ ++ P EA W+ P WP G I+ D +RYRP PL ++ Sbjct: 1224 TDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQ 1283 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G++ I GEK+G+VGRTG+GKS+L L RL Sbjct: 1284 GVSFKIHAGEKVGIVGRTGAGKSSLASGLLRL 1315 Score = 31.2 bits (69), Expect = 2.7 Identities = 17/48 (35%), Positives = 26/48 (54%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I I + +P L IN+++ G + VVG G+GKS+L+ AL Sbjct: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSAL 676
>MRP6_MOUSE (Q9R1S7) Multidrug resistance-associated protein 6 (ATP-binding| cassette sub-family C member 6) Length = 1498 Score = 142 bits (359), Expect = 6e-34 Identities = 75/212 (35%), Positives = 116/212 (54%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ATS +L RLE + V H ET G+ +R F+ + F ++ ++ + R+ F Sbjct: 1100 YVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPK 1159 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A+ WL LEL+G ++ + A + L + VG S+S L + + + + Sbjct: 1160 LVADRWLATNLELLGNGLVFVAATCAV-LSKAHLSAGLVGFSVSAALQVTQTLQWVVRSW 1218 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 LEN MVAVERV ++ +P EA W+ P WP G I+ D +R+RP PL ++ Sbjct: 1219 TDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQ 1278 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ I GEK+G+VGRTG+GKS+L L RL Sbjct: 1279 GVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRL 1310 Score = 33.9 bits (76), Expect = 0.42 Identities = 34/140 (24%), Positives = 69/140 (49%), Gaps = 4/140 (2%) Frame = +2 Query: 224 IGTLVLSITAFLMISLPS--NFIKKEFVGMSLSYGLSLNSL-VYFAISISCMLENDMVAV 394 + T ++++ F + +L + N + E ++L+ LN + S+ C+++ V+ Sbjct: 539 VSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQA-RVSF 597 Query: 395 ERVNQFSTLPSEAEWKKEDHLPSPNWPTNGD-IDISDLKVRYRPNTPLILKGINVSIRGG 571 +R+ F L E + S + ++ D I + + + +P L GIN+++ G Sbjct: 598 DRLAAFLCLE---EVDPNGMIASNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQG 654 Query: 572 EKIGVVGRTGSGKSTLIQAL 631 + VVG G+GKS+L+ AL Sbjct: 655 CLLAVVGPVGAGKSSLLSAL 674
>MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (ABC transporter| MOAT-C) (SMRP) Length = 1436 Score = 140 bits (354), Expect = 2e-33 Identities = 72/209 (34%), Positives = 122/209 (58%), Gaps = 1/209 (0%) Frame = +2 Query: 20 RELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANE 199 REL RL+ +T++P + H T ++ G TI + K EF + ++ + +F A Sbjct: 1036 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMR 1095 Query: 200 WLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLEN 379 WL RL++I +++ T +++S + + + G+++SY + L L F + ++ E Sbjct: 1096 WLPVRLDIISIALITSTGLMIVSGMARSLSA-YAGLAISYAVQLIGLFQFTVRLASETEA 1154 Query: 380 DMVAVERVNQF-STLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 +VER+N + TL EA + ++ P +WP G++ + ++RYR N PL+LK ++ Sbjct: 1155 RFTSVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEVTFENAEMRYRENLPLVLKKVSF 1214 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +I+ EKIG+VGRTGSGKS+L ALFRLV Sbjct: 1215 TIKPKEKIGIVGRTGSGKSSLGMALFRLV 1243 Score = 32.3 bits (72), Expect = 1.2 Identities = 18/61 (29%), Positives = 30/61 (49%) Frame = +2 Query: 449 DHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQA 628 D PSP I L+++ L I++ I G+ +G+ G GSGK++L+ A Sbjct: 554 DERPSPEEEEGKQIHTGSLRLQRT------LYNIDLEIEEGKLVGICGSVGSGKTSLVSA 607 Query: 629 L 631 + Sbjct: 608 I 608
>MRP12_ARATH (Q9C8H1) Multidrug resistance-associated protein 12 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 12) (ATP-energized glutathione S-conjugate pump 12) Length = 1495 Score = 139 bits (350), Expect = 7e-33 Identities = 73/217 (33%), Positives = 129/217 (59%), Gaps = 4/217 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y +TSRE+ RL+ VT++P+ F E + G ++IR +K + + N +++++R + Sbjct: 1070 YQSTSREVRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTLAS 1129 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMI----SLPSNFIKKEFVGMSLSYGLSLNSLVYFA 352 ++N WL R E +G +++ +TA + + + + +G+ LSY L++ +L+ Sbjct: 1130 TSSNRWLTIRSESLGGVMIWLTATFAVLRYGNAENQAVFASTMGLLLSYTLNITTLLSGV 1189 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTP 532 + + EN + +VERV + LPSEA E++ P WP+ G I D+ +RYRP P Sbjct: 1190 LRQASKAENSLNSVERVGNYIDLPSEATAIIENNRPVSGWPSRGSIQFEDVHLRYRPGLP 1249 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +L G++ + EK+GVVGRTG+GKS+++ AL+R+V Sbjct: 1250 PVLHGLSFFVYPSEKVGVVGRTGAGKSSMLNALYRIV 1286 Score = 31.2 bits (69), Expect = 2.7 Identities = 14/31 (45%), Positives = 20/31 (64%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L IN+ I G + +VG TG GK++LI A+ Sbjct: 633 LSDINLEIPVGSLVAIVGGTGEGKTSLISAM 663
>MRP11_ARATH (Q9SKX0) Multidrug resistance-associated protein 11 (EC 3.6.3.44)| (Glutathione S-conjugate transporting ATPase 11) (ATP-energized glutathione S-conjugate pump 11) Length = 1194 Score = 139 bits (349), Expect = 9e-33 Identities = 79/217 (36%), Positives = 127/217 (58%), Gaps = 5/217 (2%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y +TSREL RL+ V+++P+ FTET+ G++TIR FK E F ++ + R + Sbjct: 794 YRSTSRELRRLDSVSRSPIYASFTETLDGSSTIRAFKSEEHFVGRFIEHLTLYQRTSYSE 853 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMI-----SLPSNFIKKEFVGMSLSYGLSLNSLVYF 349 A+ WL RL+L+G++++ A + + + P +F VG++LSY L SL+ Sbjct: 854 IIASLWLSLRLQLLGSMIVLFVAVMAVLGSGGNFPISFGTPGLVGLALSYAAPLVSLLGS 913 Query: 350 AISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNT 529 ++ E +MV+VERV Q+ +P E E L S WP +G ++ ++ +RY Sbjct: 914 LLTSFTETEKEMVSVERVLQYMDVPQE-EVSGPQSL-SDKWPVHGLVEFHNVTMRYISTL 971 Query: 530 PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 P L I+ +I+GG +GV+GRTG+GKS+++ ALFRL Sbjct: 972 PPALTQISFTIQGGMHVGVIGRTGAGKSSILNALFRL 1008
>MRP6_RAT (O88269) Multidrug resistance-associated protein 6 (ATP-binding| cassette sub-family C member 6) (MRP-like protein 1) (MLP-1) Length = 1502 Score = 137 bits (346), Expect = 2e-32 Identities = 72/212 (33%), Positives = 113/212 (53%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+AT +L RLE + + V H ET G+ +R F+ + F ++ ++ + R+ F Sbjct: 1104 YVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPR 1163 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A+ WL LEL+G ++ + A + L + G S+S L + + + + Sbjct: 1164 LVADRWLAANLELLGNGLVFVAATCAV-LSKAHLSAGLAGFSVSAALQVTQTLQWVVRSW 1222 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILK 544 LEN MVAVERV + P EA W+ P WP G I+ D +R+RP P+ ++ Sbjct: 1223 TDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQPLWPCGGQIEFRDFGLRHRPELPMAVQ 1282 Query: 545 GINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ I GEK+G+VGRTG+GKS+L L RL Sbjct: 1283 GVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRL 1314 Score = 36.6 bits (83), Expect = 0.065 Identities = 36/140 (25%), Positives = 70/140 (50%), Gaps = 4/140 (2%) Frame = +2 Query: 224 IGTLVLSITAFLMISLPS--NFIKKEFVGMSLSYGLSLNSL-VYFAISISCMLENDMVAV 394 + T ++++ F + +L + N + E ++L+ LN + S+ C+++ V+ Sbjct: 539 VSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCLVQA-RVSF 597 Query: 395 ERVNQFSTLPSEAEWKKEDHLPSPNWPTNGD-IDISDLKVRYRPNTPLILKGINVSIRGG 571 +R+ F L E + SP+ ++ D I I + + +P L GIN+++ G Sbjct: 598 DRLAAFLCLE---EVDPNGMVLSPSRCSSKDRISIHNGTFAWSQESPPCLHGINLTVPQG 654 Query: 572 EKIGVVGRTGSGKSTLIQAL 631 + VVG G+GKS+L+ AL Sbjct: 655 CLLAVVGPVGAGKSSLLSAL 674
>MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4 (MRP/cMOAT-related| ABC transporter) (Multi-specific organic anion transporter-B) (MOAT-B) Length = 1325 Score = 137 bits (344), Expect = 4e-32 Identities = 79/215 (36%), Positives = 121/215 (56%), Gaps = 3/215 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKEN---EFFQENLDRINSSLRMY 175 +L TSR++ RLE T++PV H + ++ G TIR +K E E F + D + + + Sbjct: 882 FLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEA---W 938 Query: 176 FHNYAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAI 355 F + W RL+ I + + I AF + L + VG++LSY L+L + + + Sbjct: 939 FLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQ-VGLALSYALTLMGMFQWCV 997 Query: 356 SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL 535 S +EN M++VERV +++ L EA W+ + P P WP G I ++ Y P PL Sbjct: 998 RQSAEVENMMISVERVIEYTDLEKEAPWEYQKR-PPPAWPHEGVIIFDNVNFMYSPGGPL 1056 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 +LK + I+ EK+G+VGRTG+GKS+LI ALFRL Sbjct: 1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRL 1091 Score = 37.7 bits (86), Expect = 0.029 Identities = 31/114 (27%), Positives = 59/114 (51%), Gaps = 2/114 (1%) Frame = +2 Query: 296 FVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWP 475 FV ++L + L ++F +I + E +V++ R+ F L ++ ++ LPS Sbjct: 352 FVAVTLYGAVRLTVTLFFPSAIERVSEA-IVSIRRIQTFLLLDEISQRNRQ--LPSDGKK 408 Query: 476 TNGDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + + D + TP L+G++ ++R GE + VVG G+GKS+L+ A+ Sbjct: 409 M---VHVQDFTAFWDKASETPT-LQGLSFTVRPGELLAVVGPVGAGKSSLLSAV 458
>BPT1_YEAST (P14772) Bile pigment transporter 1| Length = 1559 Score = 135 bits (339), Expect = 1e-31 Identities = 70/215 (32%), Positives = 120/215 (55%), Gaps = 2/215 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ SREL RL ++ +P++ +E++ G + I + F N ++I ++ F+ Sbjct: 1139 YIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNF 1198 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNF--IKKEFVGMSLSYGLSLNSLVYFAIS 358 + N WL RL+ IG ++ TA L ++ + + VG+ +SY L + + + + Sbjct: 1199 RSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVR 1258 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLI 538 + +E ++V+VER+ ++ LP EA+ + P NWP+ G I+ + +YR N + Sbjct: 1259 TTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPV 1318 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 L INV I EK+G+VGRTG+GKSTL ALFR++ Sbjct: 1319 LNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRIL 1353
>ABCC9_RAT (Q63563) ATP-binding cassette transporter sub-family C member 9| (Sulfonylurea receptor 2) Length = 1545 Score = 133 bits (335), Expect = 4e-31 Identities = 79/214 (36%), Positives = 117/214 (54%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + S++L L+ T+ P++ HF+ET G TTIR F+ E F Q L+ +++ Y Sbjct: 1149 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFL 1208 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AAN WL R + +G ++ + IS SN VG+ L Y L++ + + + + Sbjct: 1209 SAANRWLEVRTDYLGACIVLTASIASISGSSN---SGLVGLGLLYALTITNYLNWVVRNL 1265 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSP-NWPTNGDIDISDLKVRYRPNTPLIL 541 LE M AV++VN F T+ SE D P +WP G+I I DL VRY N +L Sbjct: 1266 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1325 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 K + I+ G+K+G+ GRTGSGKS+L A FR+V Sbjct: 1326 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMV 1359
>ABCC9_MOUSE (P70170) ATP-binding cassette transporter sub-family C member 9| (Sulfonylurea receptor 2) Length = 1546 Score = 133 bits (335), Expect = 4e-31 Identities = 79/214 (36%), Positives = 117/214 (54%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + S++L L+ T+ P++ HF+ET G TTIR F+ E F Q L+ +++ Y Sbjct: 1150 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFL 1209 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AAN WL R + +G ++ + IS SN VG+ L Y L++ + + + + Sbjct: 1210 SAANRWLEVRTDYLGACIVLTASIASISGSSN---SGLVGLGLLYALTITNYLNWVVRNL 1266 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSP-NWPTNGDIDISDLKVRYRPNTPLIL 541 LE M AV++VN F T+ SE D P +WP G+I I DL VRY N +L Sbjct: 1267 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1326 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 K + I+ G+K+G+ GRTGSGKS+L A FR+V Sbjct: 1327 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMV 1360
>ABCC9_HUMAN (O60706) ATP-binding cassette transporter sub-family C member 9| (Sulfonylurea receptor 2) Length = 1549 Score = 133 bits (335), Expect = 4e-31 Identities = 79/214 (36%), Positives = 117/214 (54%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + S++L L+ T+ P++ HF+ET G TTIR F+ E F Q L+ +++ Y Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFL 1212 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AAN WL R + +G ++ + IS SN VG+ L Y L++ + + + + Sbjct: 1213 SAANRWLEVRTDYLGACIVLTASIASISGSSN---SGLVGLGLLYALTITNYLNWVVRNL 1269 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSP-NWPTNGDIDISDLKVRYRPNTPLIL 541 LE M AV++VN F T+ SE D P +WP G+I I DL VRY N +L Sbjct: 1270 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1329 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 K + I+ G+K+G+ GRTGSGKS+L A FR+V Sbjct: 1330 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMV 1363
>ABCC9_RABIT (P82451) ATP-binding cassette transporter sub-family C member 9| (Sulfonylurea receptor 2) Length = 1549 Score = 132 bits (333), Expect = 7e-31 Identities = 79/214 (36%), Positives = 117/214 (54%), Gaps = 1/214 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + S++L L+ T+ P++ HF+ET G TTIR F+ E F Q L+ +++ Y Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNIAYLFL 1212 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 AAN WL R + +G ++ + IS SN VG+ L Y L++ + + + + Sbjct: 1213 SAANRWLEVRTDYLGACIVLTASIASISGSSN---SGLVGLGLLYALTITNYLNWVVRNL 1269 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSP-NWPTNGDIDISDLKVRYRPNTPLIL 541 LE M AV++VN F T+ SE D P +WP G+I I DL VRY N +L Sbjct: 1270 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1329 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 K + I+ G+K+G+ GRTGSGKS+L A FR+V Sbjct: 1330 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMV 1363
>ABCC8_HUMAN (Q09428) ATP-binding cassette transporter sub-family C member 8| (Sulfonylurea receptor 1) Length = 1580 Score = 128 bits (321), Expect = 2e-29 Identities = 83/220 (37%), Positives = 122/220 (55%), Gaps = 7/220 (3%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + SR+L +L+ T+ P++ HF ETV G TTIR F+ E F Q+ L+ +S+ Sbjct: 1180 FRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFL 1239 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKE----FVGMSLSYGLSLNSLVYFA 352 AAN WL R+E IG V+ I A I SN + +E VG+ L+Y L +++ + + Sbjct: 1240 TAANRWLEVRMEYIGACVVLIAAVTSI---SNSLHRELSAGLVGLGLTYALMVSNYLNWM 1296 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPS---PNWPTNGDIDISDLKVRYRP 523 + +E + AV+R++ L +EAE + PS NWP G I I +L VRY Sbjct: 1297 VRNLADMELQLGAVKRIH--GLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS 1354 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + +LK +N I G+KIG+ GRTGSGKS+ A FR+V Sbjct: 1355 SLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMV 1394
>ABCC8_RAT (Q09429) ATP-binding cassette transporter sub-family C member 8| (Sulfonylurea receptor 1) Length = 1581 Score = 128 bits (321), Expect = 2e-29 Identities = 83/220 (37%), Positives = 123/220 (55%), Gaps = 7/220 (3%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + SR+L +L+ T+ P++ HF ETV G TTIR F+ E F Q+ L+ +S+ Sbjct: 1181 FRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFL 1240 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKE----FVGMSLSYGLSLNSLVYFA 352 AAN WL R+E IG V+ I A I SN + +E VG+ L+Y L +++ + + Sbjct: 1241 TAANRWLEVRMEYIGACVVLIAAATSI---SNSLHRELSAGLVGLGLTYALMVSNYLNWM 1297 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPS---PNWPTNGDIDISDLKVRYRP 523 + +E + AV+R++ + L +EAE + PS NWP G I I +L VRY Sbjct: 1298 VRNLADMEIQLGAVKRIH--TLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS 1355 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + +LK +N I G+KIG+ GRTGSGKS+ A FR+V Sbjct: 1356 SLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMV 1395
>YOR1_YEAST (P53049) Oligomycin resistance ATP-dependent permease YOR1| Length = 1477 Score = 127 bits (320), Expect = 2e-29 Identities = 70/213 (32%), Positives = 118/213 (55%), Gaps = 1/213 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y ++ RE+ RLE V ++ V ++ E + G TI+ ++ + F ++ IN + Sbjct: 1052 YQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLV 1111 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 W+G L+++ I L ++ I VG+ L+Y L L L+ + Sbjct: 1112 VVLQRWVGIFLDMVAIAFALIITLLCVTRAFP-ISAASVGVLLTYVLQLPGLLNTILRAM 1170 Query: 365 CMLENDMVAVERVNQFST-LPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLIL 541 ENDM + ER+ ++T LP EA ++K + P +WP+ G+I ++ YRP P++L Sbjct: 1171 TQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVL 1230 Query: 542 KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 K +N++I+ GEKIG+ GRTG+GKST++ AL+RL Sbjct: 1231 KNLNLNIKSGEKIGICGRTGAGKSTIMSALYRL 1263
>ABCC8_CRICR (Q09427) ATP-binding cassette transporter sub-family C member 8| (Sulfonylurea receptor 1) Length = 1581 Score = 125 bits (314), Expect = 1e-28 Identities = 82/220 (37%), Positives = 122/220 (55%), Gaps = 7/220 (3%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + SR+L +L+ T+ P++ HF ETV G TTIR F+ E F Q+ L+ +S+ Sbjct: 1181 FRVASRDLQQLDDTTQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFL 1240 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEF----VGMSLSYGLSLNSLVYFA 352 AAN WL +E IG V+ I A IS N + +E VG+ L+Y L +++ + + Sbjct: 1241 TAANRWLEVCMEYIGACVVLIAAATSIS---NSLHRELSAGLVGLGLTYALMVSNYLNWM 1297 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPS---PNWPTNGDIDISDLKVRYRP 523 + +E + AV+R++ + L +EAE + PS NWP G I I +L VRY Sbjct: 1298 VRNLADMEIQLGAVKRIH--ALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS 1355 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + +LK +N I G+KIG+ GRTGSGKS+ A FR+V Sbjct: 1356 SLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMV 1395
>L259_DROME (P91660) Probable multidrug resistance-associated protein| lethal(2)03659 (Wunen region A protein) Length = 1290 Score = 117 bits (294), Expect = 2e-26 Identities = 69/215 (32%), Positives = 114/215 (53%), Gaps = 3/215 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 YL TSR+L R+E + ++PV H ++ G TTIR + +E ++ +F Sbjct: 874 YLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMY 933 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + ++ G+ + I + +SI + P VG+ ++ + L +V + + + Sbjct: 934 ISTSQAFGYCMNCICVIYISIITLSFFAFPPG--NGADVGLVITQAMGLIDMVQWGVRQT 991 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKK-EDHLPSPNWPTNGDIDISDLKVRYRPNTPL-- 535 LEN M AVERV ++ ++ E + +D P WP G+I +L +RY PN Sbjct: 992 AELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAEN 1051 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 +LK ++ I+ EK+G+VGRTG+GKS+LI ALFRL Sbjct: 1052 VLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL 1086 Score = 56.6 bits (135), Expect = 6e-08 Identities = 39/119 (32%), Positives = 61/119 (51%), Gaps = 14/119 (11%) Frame = +2 Query: 317 YGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPS-----EAEWKKEDHLPSPNWPTN 481 Y + L ++ + S + ++ RV QF ++E +D +P N P+N Sbjct: 347 YNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPG-NPPSN 405 Query: 482 GD--------IDISDLKVRYRPNTP-LILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + I I DLK ++ PN+P L GIN+ I+ G + V+G TGSGKS+LIQA+ Sbjct: 406 NNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAI 464
>ABCCB_HUMAN (Q96J66) ATP-binding cassette transporter sub-family C member 11| (Multidrug resistance-associated protein 8) Length = 1382 Score = 114 bits (284), Expect = 3e-25 Identities = 73/209 (34%), Positives = 112/209 (53%), Gaps = 5/209 (2%) Frame = +2 Query: 32 RLEGVTKAPVIDHFTETVVGATTIRCFKKENEF---FQENLDRINSSLRMYFHNYAANEW 202 RLE +++P+ H ++ G ++I + K +F F+ D N+ L ++ ++ W Sbjct: 989 RLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFL---SSTRW 1045 Query: 203 LGFRLELIGTLV-LSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLEN 379 + RLE++ LV L++ F+ + S F M+++ L L S I E Sbjct: 1046 MALRLEIMTNLVTLAVALFVAFGISST--PYSFKVMAVNIVLQLASSFQATARIGLETEA 1103 Query: 380 DMVAVERVNQFSTL-PSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 AVER+ Q+ + SEA E WP +G+I D ++YR NTP +L GIN+ Sbjct: 1104 QFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINL 1163 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +IRG E +G+VGRTGSGKS+L ALFRLV Sbjct: 1164 TIRGHEVVGIVGRTGSGKSSLGMALFRLV 1192 Score = 32.7 bits (73), Expect = 0.94 Identities = 15/31 (48%), Positives = 21/31 (67%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L IN+ + G +GV G TGSGKS+L+ A+ Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557
>CFTR_TRIVU (Q5D1Z7) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1478 Score = 104 bits (259), Expect = 3e-22 Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 17/230 (7%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE + P+ H ++ G T+R F ++ F +N +F Sbjct: 1032 FLQTSQQLKQLESEARTPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1091 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I I F+ I + + VG+ L+ +++ S + +A++ S Sbjct: 1092 MSTLRWFQMRIEIIFVTFFCIVTFISILTTGDGEGR--VGILLTLAMNIMSTLQWAVNSS 1149 Query: 365 CMLENDMVAVERVNQFSTLPSE-------AEWKKE----------DHLPSPNWPTNGDID 493 +++ M +V RV +F +PSE + KK +H+ NWP+ G + Sbjct: 1150 IDVDSLMRSVSRVFKFIDMPSEEPLPPKPTKSKKNQLSQVLIIENEHVKKENWPSGGQMT 1209 Query: 494 ISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + DL +Y +L+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1210 VKDLTAKYIDGGNAVLENISFSISSGQRVGLLGRTGSGKSTLLAAFLRLL 1259 Score = 30.4 bits (67), Expect = 4.7 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 440 VLKNISFKIEKGQLLAVAGSTGAGKTSLLMLI 471
>ABC1_SCHPO (Q92337) ATP-binding cassette transporter abc1| Length = 1427 Score = 103 bits (256), Expect = 6e-22 Identities = 72/214 (33%), Positives = 104/214 (48%), Gaps = 3/214 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y ++LT L+ +PV ET+ G T IR FKKE F EN+ I+ ++ + + Sbjct: 1020 YSKAQKQLTSLQSSRTSPVFTMLGETLGGITVIRAFKKEKIFEHENMAFIDDMIQPLYIS 1079 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 +A N WL R + I LV T +I+L I VG SL+ + N V + + Sbjct: 1080 FAINRWLAIRTDGISGLVGFSTG--LIALLRQNIPPGLVGFSLNSAIGFNISVLVFVRAN 1137 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSP---NWPTNGDIDISDLKVRYRPNTPL 535 + + R+ ++ LPSE + L P WPT G + I +L V Y Sbjct: 1138 NEILTYINNFRRLYEYMLLPSEKN--ESSCLTKPMNKEWPTLGHVSIKNLTVSYSIGQAA 1195 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 +L+ IN+ I EKI +VGRTGSGKST+ L R Sbjct: 1196 VLEDINLEILPKEKIAIVGRTGSGKSTMGLTLLR 1229 Score = 33.5 bits (75), Expect = 0.55 Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 9/73 (12%) Frame = +2 Query: 440 KKEDHLPSPNWPTNGDIDISD--------LKVRYRPNTPLI-LKGINVSIRGGEKIGVVG 592 K+ D+ N + I+ SD L P+T L LK +N +I + VVG Sbjct: 555 KRVDNFVYGNMVNDSSIESSDSFVFENTSLSWSPTPSTALFQLKNLNFTIPRNQFTLVVG 614 Query: 593 RTGSGKSTLIQAL 631 TGSGKSTL AL Sbjct: 615 STGSGKSTLAMAL 627
>CFTR_SQUAC (P26362) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1492 Score = 101 bits (252), Expect = 2e-21 Identities = 58/227 (25%), Positives = 123/227 (54%), Gaps = 14/227 (6%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F +++ F +N +F Sbjct: 1047 FLRTSQQLKQLESEARSPIFSHLITSLRGLWTVRAFGRQSYFETLFHKALNLHTANWFLY 1106 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R++++ VL A I++ ++ + + VG+ L+ +++ S + +A++ S Sbjct: 1107 LSTLRWFQMRIDIV--FVLFFIAVTFIAIATHDVGEGQVGIILTLAMNITSTLQWAVNSS 1164 Query: 365 CMLENDMVAVERVNQFSTLPSE-AEWKKEDHLPSPN-------------WPTNGDIDISD 502 ++ M +V RV ++ +P E +E K + +P+ WP+ G + +++ Sbjct: 1165 IDVDGLMRSVSRVFKYIDIPPEGSETKNRHNANNPSDVLVIENKHLTKEWPSGGQMMVNN 1224 Query: 503 LKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 L +Y + +L+ ++ S+ G+++G++GRTG+GKSTL+ AL RL+ Sbjct: 1225 LTAKYTSDGRAVLQDLSFSVNAGQRVGLLGRTGAGKSTLLSALLRLL 1271 Score = 32.7 bits (73), Expect = 0.94 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ + GE + + G TGSGKS+L+ + Sbjct: 441 VLKNISFKLEKGELLAIAGSTGSGKSSLLMMI 472
>CFTR_CALMO (Q2QLB4) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1480 Score = 99.0 bits (245), Expect = 1e-20 Identities = 65/231 (28%), Positives = 117/231 (50%), Gaps = 18/231 (7%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESAGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKE-----------------DHLPSPN-WPTNGDI 490 +++ M +V RV +F +P+E + K H+ + WP+ G + Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEGKPTKSTKAYKNGQLSKVMIIENSHVKKDDIWPSGGQM 1210 Query: 491 DISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 TIKDLTAKYIEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_PIG (Q6PQZ2) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1482 Score = 99.0 bits (245), Expect = 1e-20 Identities = 63/232 (27%), Positives = 116/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1034 FLHTSQQLKQLESEGRSPIFTHLITSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1093 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1094 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1151 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E + PS + WP+ G Sbjct: 1152 IDVDSLMRSVSRVFKFIDMPAEGDQPNRSFKPSKDGQLSKVMIIENQHVKKDDIWPSGGQ 1211 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y +L+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1212 MTVKDLTAKYVDGGNAVLENISFSISPGQRVGLLGRTGSGKSTLLLAFLRLL 1263 Score = 30.0 bits (66), Expect = 6.1 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDISFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_HORSE (Q2QLA3) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 98.6 bits (244), Expect = 1e-20 Identities = 64/232 (27%), Positives = 116/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E + PS + WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEDSKPTKSVKPSKDGQLSKVMIIENQYVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTDGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 30.0 bits (66), Expect = 6.1 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 439 VLKDISFKIERGQLLAVAGSTGAGKTSLLMMI 470
>CFTR_RABIT (Q00554) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1480 Score = 98.2 bits (243), Expect = 2e-20 Identities = 67/232 (28%), Positives = 118/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I L AF IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMIFVLFFIAVAF--ISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+EA+ K PS N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEAKSTKSIK-PSSNCQLSKVMIIENQHVKKDDVWPSGGQ 1209 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + L +Y + IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1210 MTVKGLTAKYIDSGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261 Score = 30.0 bits (66), Expect = 6.1 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDISFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_PONPY (Q2IBE4) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1480 Score = 98.2 bits (243), Expect = 2e-20 Identities = 64/231 (27%), Positives = 117/231 (50%), Gaps = 18/231 (7%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKE-----------------DHLPSPN-WPTNGDI 490 +++ M +V RV +F +P+E + K H+ + WP+ G + Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKLMIIENSHVKKDDIWPSGGQM 1210 Query: 491 DISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 TVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_HUMAN (P13569) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1480 Score = 98.2 bits (243), Expect = 2e-20 Identities = 64/231 (27%), Positives = 117/231 (50%), Gaps = 18/231 (7%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKE-----------------DHLPSPN-WPTNGDI 490 +++ M +V RV +F +P+E + K H+ + WP+ G + Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQM 1210 Query: 491 DISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 TVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_DIDMA (Q2QL74) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1482 Score = 97.8 bits (242), Expect = 2e-20 Identities = 63/232 (27%), Positives = 116/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE + P+ H ++ G T+R F ++ F +N +F Sbjct: 1034 FLQTSQQLKQLESEARTPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTASWFLY 1093 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+EL+ V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1094 LSTLRWFQMRIELV--FVIFFIAVTFISILTTGDGEGRVGILLTLAMNIMSTLQWAVNSS 1151 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWK------------------KEDHLPSPN-WPTNGD 487 +++ M +V RV +F +P+E + +H+ N WP+ G Sbjct: 1152 IDVDSLMRSVSRVFKFIDMPTEEPLPAKPTKSLKKNQLSQVLIIENEHVNKENNWPSGGQ 1211 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y +L+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1212 MIVKDLTAKYTDGGNAVLENISFSISPGQRVGLLGRTGSGKSTLLAAFLRLL 1263 Score = 30.4 bits (67), Expect = 4.7 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 440 VLKNISFKIEKGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_PANTR (Q2QLE5) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1480 Score = 97.4 bits (241), Expect = 3e-20 Identities = 65/232 (28%), Positives = 116/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E + K P N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEGKPTKSTK-PYKNGQLSKVMIIENSHVKKDYIWPSGGQ 1209 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_CARPS (Q2QLC5) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1482 Score = 97.4 bits (241), Expect = 3e-20 Identities = 66/232 (28%), Positives = 117/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1034 FLPTSQQLKQLESEGRSPIFTHLVTSLRGLWTLRAFGRQPYFEALFHKALNLHTANWFLY 1093 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1094 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAMNSS 1151 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E + PS + WP G Sbjct: 1152 IDVDSLMRSVSRVFKFIDMPTEESKSTKLIKPSKDDKLTKVMIIENQHVKKDDLWPLGGQ 1211 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + I +L +Y N IL+ I+ SI G+++G++GRTGSGKSTL+ AL RL+ Sbjct: 1212 MTIKNLIAKYTDNGNAILENISFSISPGQRVGLLGRTGSGKSTLLSALLRLL 1263 Score = 31.2 bits (69), Expect = 2.7 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +L+ IN I G+ + + G TG+GK++L+ L Sbjct: 440 VLRDINFQIERGQLLAIAGSTGAGKTSLLMML 471
>CFTR_PAPAN (Q9TSP5) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 97.4 bits (241), Expect = 3e-20 Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E P N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEEGKPTRSTKPYKNGQLSKVMVIENSHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTEGGNPILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_MACNE (Q9TUQ2) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 97.4 bits (241), Expect = 3e-20 Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E P N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEEGKPTRSTKPYKNGQLSKVMVIENSHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTEGGNPILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_MACMU (Q00553) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 97.4 bits (241), Expect = 3e-20 Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E P N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEEGKPTRSTKPYKNGQLSKVMVIENSHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTEGGNPILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_MACFU (Q7JII7) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 97.4 bits (241), Expect = 3e-20 Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E P N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEEGKPTRSTKPYKNGQLSKVMVIENSHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTEGGNPILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_MACFA (Q7JII8) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 97.4 bits (241), Expect = 3e-20 Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E P N WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEEGKPTRSTKPYKNGQLSKVMVIENSHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTEGGNPILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_MICMU (Q2QL83) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 96.7 bits (239), Expect = 5e-20 Identities = 62/232 (26%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E++ + + F IS+ + + VG+ L+ +++ + +A++ S Sbjct: 1093 LSTLRWFQMRIEMVFVIFFIVVTF--ISILTTGEGEGQVGIILTLAMNIMGTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E PS + WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEEGKSTRSIKPSKDCHLSKVMVFENPHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL RY IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTARYLDGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 30.0 bits (66), Expect = 6.1 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDISFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_CALJA (Q2QLF9) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 96.7 bits (239), Expect = 5e-20 Identities = 66/233 (28%), Positives = 118/233 (50%), Gaps = 20/233 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLQTSQQLKQLESAGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ S + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWK-------------------KEDHLPSPN-WPTNG 484 +++ M +V RV +F +P+E E K + H+ + WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTE-EGKPTKSTKAYKNGQLSKVMIIENSHVKKDDIWPSGG 1209 Query: 485 DIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + I DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1210 QMTIKDLTAKYIEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1262 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_MOUSE (P26361) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1476 Score = 96.7 bits (239), Expect = 5e-20 Identities = 61/232 (26%), Positives = 116/232 (50%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L T+++L +LE ++P+ H ++ G T+R F+++ F +N +F Sbjct: 1028 FLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMY 1087 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 A W R+++I L + F IS+ + + G+ L+ +++ S + +A++ S Sbjct: 1088 LATLRWFQMRIDMIFVLFFIVVTF--ISILTTGEGEGTAGIILTLAMNIMSTLQWAVNSS 1145 Query: 365 CMLENDMVAVERVNQFSTLPSEAEW-------------------KKEDHLPSPNWPTNGD 487 ++ M +V RV +F + +E K E S WP+ G+ Sbjct: 1146 IDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIWPSGGE 1205 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL V+Y + +L+ I+ SI G+++G++GRTGSGKSTL+ A R++ Sbjct: 1206 MVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRML 1257 Score = 35.8 bits (81), Expect = 0.11 Identities = 14/32 (43%), Positives = 23/32 (71%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN++I GE + + G TGSGK++L+ + Sbjct: 440 VLKNINLNIEKGEMLAITGSTGSGKTSLLMLI 471
>CFTR_CANFA (Q5U820) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1483 Score = 95.9 bits (237), Expect = 9e-20 Identities = 65/233 (27%), Positives = 118/233 (50%), Gaps = 20/233 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1034 FLHTSQQLKQLESEGRSPIFTHLLTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1093 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ + +A++ S Sbjct: 1094 LSTLRWFQMRMEII--FVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMGTLQWAVNPS 1151 Query: 365 CMLENDMVAVERVNQFSTLPSE-AEWKKEDHLPSPN-------------------WPTNG 484 +++ M +V RV +F +P+E ++ + PS + WP+ G Sbjct: 1152 IEVDSLMRSVSRVFKFIDMPTEESKPPTKSFKPSKDAQLSKVTITENRHVREDDIWPSGG 1211 Query: 485 DIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ AL RLV Sbjct: 1212 QMTVKDLTAKYIDGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSALLRLV 1264 Score = 32.0 bits (71), Expect = 1.6 Identities = 13/32 (40%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN I G+ + V G TG+GK++L+ + Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMI 471
>CFTR_SHEEP (Q00555) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 95.1 bits (235), Expect = 2e-19 Identities = 63/232 (27%), Positives = 114/232 (49%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1033 FLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMGTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E PS + WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEDGKPNNSFRPSKDSQPSKVMIIENQHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYIDGGNAILENISFSISPGQRVGLLGRTGSGKSTLLLAFLRLL 1262 Score = 30.0 bits (66), Expect = 6.1 Identities = 12/32 (37%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK I+ I G+ + V G TG+GK++L+ + Sbjct: 439 VLKDISFKIERGQLLAVAGSTGAGKTSLLMMI 470
>CFTR_BOVIN (P35071) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1481 Score = 94.7 bits (234), Expect = 2e-19 Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 19/232 (8%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R ++ F +N +F Sbjct: 1033 FLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRALDRQPYFETLFHKALNLHTANWFLY 1092 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W R+E+I V+ A IS+ + + VG+ L+ +++ + +A++ S Sbjct: 1093 LSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMGTLQWAVNSS 1150 Query: 365 CMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN-------------------WPTNGD 487 +++ M +V RV +F +P+E PS + WP+ G Sbjct: 1151 IDVDSLMRSVSRVFKFIDMPTEDGKPNNSFRPSKDSQPSKVMIIENQHVKKDDIWPSGGQ 1210 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + + DL +Y IL+ I+ SI G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1211 MTVKDLTAKYTDGGNAILENISFSISSGQRVGLLGRTGSGKSTLLLAFLRLL 1262 Score = 29.6 bits (65), Expect = 8.0 Identities = 12/29 (41%), Positives = 20/29 (68%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLI 622 +LK I+ I G+ + V G TG+GK++L+ Sbjct: 439 VLKDISFKIERGQLLAVAGSTGAGKTSLL 467
>CFTR_XENLA (P26363) Cystic fibrosis transmembrane conductance regulator (CFTR)| (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) Length = 1485 Score = 94.4 bits (233), Expect = 3e-19 Identities = 61/229 (26%), Positives = 116/229 (50%), Gaps = 16/229 (6%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 +L TS++L +LE ++P+ H ++ G T+R F ++ F +N +F Sbjct: 1038 FLHTSQQLKQLESKARSPIFAHLITSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLY 1097 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISIS 364 + W +E+I V+ A IS+ ++ +E VG+ L+ +++ + + +A++ S Sbjct: 1098 LSTLRWFQMTIEMI--FVIFFIAVSFISIATSGAGEEKVGIVLTLAMNIMNTLQWAVNAS 1155 Query: 365 CMLENDMVAVERVNQFSTLPSEA----EWKKEDHLP------------SPNWPTNGDIDI 496 +++ M +V R+ +F LP E KE+ L + WP+ G + + Sbjct: 1156 IDVDSLMRSVSRIFRFIDLPVEELINENKNKEEQLSEVLIYENDYVKKTQVWPSGGQMTV 1215 Query: 497 SDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +L Y +L+ I+ S+ G+++G++GRTGSGKSTL+ A RL+ Sbjct: 1216 KNLSANYIDGGNTVLENISFSLSPGQRVGLLGRTGSGKSTLLSAFLRLL 1264 Score = 30.8 bits (68), Expect = 3.6 Identities = 11/32 (34%), Positives = 21/32 (65%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +L+ IN I G+ + + G TG+GK++L+ + Sbjct: 441 VLRNINFKIEKGQLLAIAGSTGAGKTSLLMMI 472
>MDR_LEITA (P21441) Multidrug resistance protein (EC 3.6.3.44) (P-glycoprotein)| Length = 1548 Score = 94.0 bits (232), Expect = 3e-19 Identities = 68/250 (27%), Positives = 116/250 (46%), Gaps = 37/250 (14%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y A++RE R++ + +PV E++ G TI + K + QE L R++ + Sbjct: 1094 YNASNRETRRIKSIAHSPVFTLLEESLQGQRTIATYGKLHLVLQEALGRLDVVYSALYMQ 1153 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVG---MSLSYGLSLNSLVYFAI 355 +N WLG RLE + +V + AF+ + + +G +SL+ ++L + + + Sbjct: 1154 NVSNRWLGVRLEFLSCVVTFMVAFIGVIGKMEGASSQNIGLISLSLTMSMTLTETLNWLV 1213 Query: 356 SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLP------------------------- 460 M+E +M +VERV ++ E E +H+P Sbjct: 1214 RQVAMVEANMNSVERVLHYT---QEVE---HEHVPEMGELVAQLVRSESGRGANVTETVV 1267 Query: 461 --------SPNWPTN-GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKS 613 S P G + + +++RYR PL+L+G++ I EK+G+VGRTGSGKS Sbjct: 1268 IESAGAASSALHPVQAGSLVLEGVQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKS 1327 Query: 614 TLIQALFRLV 643 TL+ R+V Sbjct: 1328 TLLLTFMRMV 1337 Score = 33.5 bits (75), Expect = 0.55 Identities = 18/50 (36%), Positives = 33/50 (66%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 G+++ D + Y+ + +L+ ++++I G+ V+G TGSGKSTL+ AL Sbjct: 632 GEVEEGDREY-YQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGAL 680
>HLYB_PROVU (P11599) Alpha-hemolysin translocation ATP-binding protein hlyB| Length = 707 Score = 65.1 bits (157), Expect = 2e-10 Identities = 38/116 (32%), Positives = 67/116 (57%), Gaps = 3/116 (2%) Frame = +2 Query: 299 VGMSLSYGLSLNSLVYFAISISCMLENDM---VAVERVNQFSTLPSEAEWKKEDHLPSPN 469 +G +++ + +V I ++ + ++ ++V R+ P+E+ K L P Sbjct: 407 IGQLIAFNMLAGQIVAPVIRLAQLWQDFQQVGISVTRLGDVLNYPTESYQGK---LTLPE 463 Query: 470 WPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 NGDI +++ RY+P+ P+IL IN++I+ GE IG+VGR+GSGKSTL + + R Sbjct: 464 --INGDISFRNIRFRYKPDAPIILNNINLNIKQGEIIGIVGRSGSGKSTLTKLIQR 517
>HLYBP_ECOLI (P08716) Alpha-hemolysin translocation ATP-binding protein hlyB| Length = 707 Score = 65.1 bits (157), Expect = 2e-10 Identities = 36/84 (42%), Positives = 54/84 (64%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E+ K L P NGDI +++ RY+P++P+IL IN+SI+ Sbjct: 439 ISVTRLGDVLNSPTESYHGK---LTLPE--INGDITFRNIRFRYKPDSPVILDNINLSIK 493 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + + R Sbjct: 494 QGEVIGIVGRSGSGKSTLTKLIQR 517
>HLYBC_ECOLI (P10089) Alpha-hemolysin translocation ATP-binding protein hlyB| Length = 707 Score = 65.1 bits (157), Expect = 2e-10 Identities = 36/84 (42%), Positives = 54/84 (64%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E+ K L P NGDI +++ RY+P++P+IL IN+SI+ Sbjct: 439 ISVTRLGDVLNSPTESYHGK---LALPE--INGDITFRNIRFRYKPDSPVILDNINLSIK 493 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + + R Sbjct: 494 QGEVIGIVGRSGSGKSTLTKLIQR 517
>HLYB3_ECOLI (Q47258) Alpha-hemolysin translocation ATP-binding protein hlyB| Length = 707 Score = 65.1 bits (157), Expect = 2e-10 Identities = 36/84 (42%), Positives = 54/84 (64%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E+ K L P NGDI +++ RY+P++P+IL IN+SI+ Sbjct: 439 ISVTRLGDVLNSPTESYHGK---LALPE--INGDITFRNIRFRYKPDSPVILDNINLSIK 493 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + + R Sbjct: 494 QGEVIGIVGRSGSGKSTLTKLIQR 517
>PAXB_PASAE (Q9RCG7) Exotoxin translocation ATP-binding protein paxB (EC| 3.6.3.43) Length = 711 Score = 63.9 bits (154), Expect = 4e-10 Identities = 27/53 (50%), Positives = 41/53 (77%) Frame = +2 Query: 479 NGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 NGD+ +++ RY+P+ P+IL +N++I+ GE IG+VGR+GSGKSTL + L R Sbjct: 469 NGDVTFKNIRFRYKPDAPIILNDVNLTIKQGEVIGIVGRSGSGKSTLTKLLQR 521
>LKTB_PASTR (Q933E0) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKTB7_PASHA (P0C086) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKB2A_PASHA (Q93FH0) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKB1B_PASHA (Q93FH6) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKB1A_PASHA (P16532) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKB16_PASHA (Q93FH3) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKB14_PASHA (P0C087) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LKB13_PASHA (Q93FH2) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 63.5 bits (153), Expect = 5e-10 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGDISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>HLYB_ECOL6 (Q8FDZ8) Alpha-hemolysin translocation ATP-binding protein hlyB| Length = 707 Score = 63.2 bits (152), Expect = 7e-10 Identities = 35/84 (41%), Positives = 54/84 (64%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E+ K L P NG+I +++ RY+P++P+IL IN+SI+ Sbjct: 439 ISVTRLGDVLNSPTESYHGK---LALPE--INGNITFRNIRFRYKPDSPVILDNINLSIK 493 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + + R Sbjct: 494 QGEVIGIVGRSGSGKSTLTKLIQR 517
>LKTB_PASSP (P55122) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 62.0 bits (149), Expect = 1e-09 Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%) Frame = +2 Query: 194 NEWLGFRLELIGTLVLS-ITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCM 370 N WLG L + G L + + AF M+S G ++ + L L + Sbjct: 393 NLWLGAHLVISGDLSIGQLIAFNMLS-----------GQVIAPVIRLAQLWQDFTQVG-- 439 Query: 371 LENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGI 550 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL + Sbjct: 440 -----ISVTRLGDVLNSPTE-QYQGKLSLPE----IQGDIAFKNIRFRYKPDAPTILNNV 489 Query: 551 NVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 N+ I+ GE IG+VGR+GSGKSTL + L R Sbjct: 490 NLEIKKGEVIGIVGRSGSGKSTLTKLLQR 518
>RTX1B_ACTPL (P26760) Toxin RTX-I translocation ATP-binding protein (RTX-I toxin| determinant B) (APX-IB) (HLY-IB) (Cytolysin IB) (CLY-IB) Length = 707 Score = 61.6 bits (148), Expect = 2e-09 Identities = 34/84 (40%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E+ K L P GDI +++ RY+P+ P+IL +N+SI+ Sbjct: 439 ISVTRLGDVLNSPTESYQGK---LALPE--IKGDITFRNIRFRYKPDAPVILNDVNLSIQ 493 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + + R Sbjct: 494 QGEVIGIVGRSGSGKSTLTKLIQR 517
>LKTB_MANGL (Q933I3) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/84 (39%), Positives = 52/84 (61%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP GDI +++ RY+P+ P IL +N+ I+ Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IQGDIAFKNIRFRYKPDAPTILNNVNLEIK 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 KGEVIGIVGRSGSGKSTLTKLLQR 518
>RTX3B_ACTPL (Q04473) Toxin RTX-III translocation ATP-binding protein (RTX-III| toxin determinant B) (APX-IIIB) (Cytolysin IIIB) (CLY-IIIB) Length = 711 Score = 61.2 bits (147), Expect = 2e-09 Identities = 27/52 (51%), Positives = 39/52 (75%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI ++ RY+P+ P+IL +N+S++ GE IG+VGR+GSGKSTL + L R Sbjct: 470 GDIAFKHIRFRYKPDAPIILDDVNLSVKQGEVIGIVGRSGSGKSTLTKLLQR 521
>Y015_MYCGE (P47261) Hypothetical ABC transporter ATP-binding protein MG015| Length = 589 Score = 61.2 bits (147), Expect = 2e-09 Identities = 52/175 (29%), Positives = 82/175 (46%), Gaps = 4/175 (2%) Frame = +2 Query: 125 EFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSI-TAFLMISLPSNFIKKEFV 301 +F Q N I ++R ++ W GF + + +SI TAF + S+PS I Sbjct: 231 DFDQYNKSMIKPTVRGNTYSIFLFSWFGFISNITYLVSISIATAFSVNSIPSFGISVINY 290 Query: 302 GMSLSYGLSLNSLVYFAISISCM---LENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNW 472 LSY SL + I + ++ +V+ ERV + L E + D LP Sbjct: 291 SFMLSYIASLRQITLALDQIFTLWNLVQLGVVSAERVFKVLDLNVEKDTATIDKLPD--- 347 Query: 473 PTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G+I ++ Y + P L GIN S++ G+ + +VG TG+GKST+I L + Sbjct: 348 -IKGNIRFENVAFGYNKDKPT-LTGINFSVKHGDVVAIVGPTGAGKSTIINLLMK 400
>LKTB_ACTAC (P23702) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 707 Score = 60.5 bits (145), Expect = 4e-09 Identities = 27/52 (51%), Positives = 39/52 (75%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G+I ++K RY+P++P+IL IN+ I GE IG+VGR+GSGKSTL + + R Sbjct: 466 GEISFRNIKFRYKPDSPMILNNINLDISQGEVIGIVGRSGSGKSTLTKLIQR 517
>LKB2B_PASHA (Q93FG6) Leukotoxin translocation ATP-binding protein lktB (EC| 3.6.3.43) Length = 708 Score = 60.1 bits (144), Expect = 6e-09 Identities = 33/84 (39%), Positives = 51/84 (60%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++V R+ P+E +++ + LP G I +++ RY+P+ P IL +N+ IR Sbjct: 440 ISVTRLGDVLNSPTE-QYQGKLSLPE----IKGYISFKNIRFRYKPDAPTILNNVNLEIR 494 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 GE IG+VGR+GSGKSTL + L R Sbjct: 495 QGEVIGIVGRSGSGKSTLTKLLQR 518
>LCNC_LACLA (Q00564) Lactococcin-A transport/processing ATP-binding protein| lcnC (EC 3.4.22.-) Length = 715 Score = 57.8 bits (138), Expect = 3e-08 Identities = 57/201 (28%), Positives = 96/201 (47%), Gaps = 6/201 (2%) Frame = +2 Query: 47 TKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELI 226 T A + E + G TI+ E E +Q+ S L+ F +E + ++ I Sbjct: 339 TNAVLNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKKAF-TLQKSEAIQGLIKAI 397 Query: 227 GTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFA------ISISCMLENDMV 388 L LS+T L +K +G +++ L+ YF I++ L+ V Sbjct: 398 IQLTLSVT-ILWFGATLVISQKITLGQLITFNALLS---YFTNPITNIINLQTKLQKARV 453 Query: 389 AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRG 568 A ER+N+ +PSE E KK + S + ++++SD+ +Y +L I +SI+ Sbjct: 454 ANERLNEVYLVPSEFEEKKTELSLS-----HFNLNMSDISYQYGFGRK-VLSEIELSIKE 507 Query: 569 GEKIGVVGRTGSGKSTLIQAL 631 EK+ +VG +GSGKSTL++ L Sbjct: 508 NEKLTIVGMSGSGKSTLVKLL 528
>MDLB_BUCAP (Q8K984) Multidrug resistance-like ATP-binding protein mdlB (EC| 3.6.3.44) Length = 580 Score = 55.8 bits (133), Expect = 1e-07 Identities = 57/197 (28%), Positives = 92/197 (46%), Gaps = 4/197 (2%) Frame = +2 Query: 53 APVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGT 232 A + + F ET+ G I+ F+++ F EN + +S L Y + GF L + + Sbjct: 201 ANINNKFNETINGMNVIQQFRQQTRF--ENNIKESSELH-YLARMKILKLDGFLLRPLLS 257 Query: 233 LVLSITAFLMISLPSNF-IKKEFVGMSLSYGLSLNSLVYFAISISC---MLENDMVAVER 400 L+ ++ + L S F I VG+ ++ L L ISI+ +L+ +VA ER Sbjct: 258 LLSALVLCSFMFLFSYFSIGVYEVGVLYAFITYLGRLNEPLISITIQQSILQQAIVAGER 317 Query: 401 VNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKI 580 + P + E+ + S G I+I +L +Y+ + IL IN+ I + Sbjct: 318 IFSLIDSPKQKYGNNEEEIKS------GKINIKNLSFKYKESGENILNNINIYIPSKSFV 371 Query: 581 GVVGRTGSGKSTLIQAL 631 VG+TGSGKSTL L Sbjct: 372 AFVGQTGSGKSTLANLL 388
>MDLB_BUCBP (Q89A96) Multidrug resistance-like ATP-binding protein mdlB (EC| 3.6.3.44) Length = 578 Score = 55.1 bits (131), Expect = 2e-07 Identities = 55/213 (25%), Positives = 92/213 (43%), Gaps = 4/213 (1%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y S+ + R V A + + F E + G I+ F +E +F ++++ +I S+ Y+ Sbjct: 183 YQYFSKPILRKIKVYIANIYNIFNEIINGIDVIQQFHQEQKF-RKSIKKI--SISHYYFR 239 Query: 185 YAANEWLGFRLELI----GTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFA 352 + F L + TL+L + P F + + ++Y LN + Sbjct: 240 MKILKLDSFLLRPLLNFCSTLILCGLILIFGIYPIGFFEIGTLYAFITYLNRLNEPLITI 299 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTP 532 S + + +VA ER+ + P + H G+I + +L Y N Sbjct: 300 TSQQSIFQQAIVAGERIFEIIHTPKQQYGDDSLHF------REGNIKVKNLYFSYTNNNV 353 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN+ I + I VGRTGSGKSTL + L Sbjct: 354 YVLKNINIFIPSKQFIAFVGRTGSGKSTLSKLL 386
>MDLB_ECOLI (P0AAG5) Multidrug resistance-like ATP-binding protein mdlB (EC| 3.6.3.44) Length = 593 Score = 54.3 bits (129), Expect = 3e-07 Identities = 56/211 (26%), Positives = 90/211 (42%), Gaps = 2/211 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y S + R A + D F E + G + I+ F+++ F + + S Sbjct: 185 YQRYSTPIVRRVRAYLADINDGFNEIINGMSVIQQFRQQARFGERMGEASRSHYMARMQT 244 Query: 185 YAANEWLGFR--LELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAIS 358 + +L R L L +L+L L S I+ + +SY LN + + Sbjct: 245 LRLDGFL-LRPLLSLFSSLILCGLLMLFGFSASGTIEVGVLYAFISYLGRLNEPLIELTT 303 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLI 538 ML+ +VA ERV + P + + L S G I++ ++ YR + L+ Sbjct: 304 QQAMLQQAVVAGERVFELMDGPRQQYGNDDRPLQS------GTIEVDNVSFAYRDDN-LV 356 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 LK IN+S+ + +VG TGSGKSTL L Sbjct: 357 LKNINLSVPSRNFVALVGHTGSGKSTLASLL 387
>MDLB_ECOL6 (P0AAG6) Multidrug resistance-like ATP-binding protein mdlB (EC| 3.6.3.44) Length = 593 Score = 54.3 bits (129), Expect = 3e-07 Identities = 56/211 (26%), Positives = 90/211 (42%), Gaps = 2/211 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y S + R A + D F E + G + I+ F+++ F + + S Sbjct: 185 YQRYSTPIVRRVRAYLADINDGFNEIINGMSVIQQFRQQARFGERMGEASRSHYMARMQT 244 Query: 185 YAANEWLGFR--LELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAIS 358 + +L R L L +L+L L S I+ + +SY LN + + Sbjct: 245 LRLDGFL-LRPLLSLFSSLILCGLLMLFGFSASGTIEVGVLYAFISYLGRLNEPLIELTT 303 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLI 538 ML+ +VA ERV + P + + L S G I++ ++ YR + L+ Sbjct: 304 QQAMLQQAVVAGERVFELMDGPRQQYGNDDRPLQS------GTIEVDNVSFAYRDDN-LV 356 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 LK IN+S+ + +VG TGSGKSTL L Sbjct: 357 LKNINLSVPSRNFVALVGHTGSGKSTLASLL 387
>MDLB_ECO57 (P0AAG7) Multidrug resistance-like ATP-binding protein mdlB (EC| 3.6.3.44) Length = 593 Score = 54.3 bits (129), Expect = 3e-07 Identities = 56/211 (26%), Positives = 90/211 (42%), Gaps = 2/211 (0%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y S + R A + D F E + G + I+ F+++ F + + S Sbjct: 185 YQRYSTPIVRRVRAYLADINDGFNEIINGMSVIQQFRQQARFGERMGEASRSHYMARMQT 244 Query: 185 YAANEWLGFR--LELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAIS 358 + +L R L L +L+L L S I+ + +SY LN + + Sbjct: 245 LRLDGFL-LRPLLSLFSSLILCGLLMLFGFSASGTIEVGVLYAFISYLGRLNEPLIELTT 303 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLI 538 ML+ +VA ERV + P + + L S G I++ ++ YR + L+ Sbjct: 304 QQAMLQQAVVAGERVFELMDGPRQQYGNDDRPLQS------GTIEVDNVSFAYRDDN-LV 356 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 LK IN+S+ + +VG TGSGKSTL L Sbjct: 357 LKNINLSVPSRNFVALVGHTGSGKSTLASLL 387
>Y019_MYCPN (P75094) Hypothetical ABC transporter ATP-binding protein MG015| homolog (D12_orf634) Length = 634 Score = 53.9 bits (128), Expect = 4e-07 Identities = 50/180 (27%), Positives = 84/180 (46%), Gaps = 8/180 (4%) Frame = +2 Query: 122 NEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSI-TAFLMISLPSNFIKKEF 298 + F + N +N +++ + W GF + +SI TAF + ++PS + Sbjct: 275 DNFDKYNRPMVNPTIKANTYAVFIYSWFGFISNITYLASISIATAFSVNNIPSFGVSAIN 334 Query: 299 VGMSLSY-------GLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHL 457 LSY L LN + S+ +++ +V+ ERV F L E+ K+ Sbjct: 335 YSFMLSYIAALRQTALPLNQI----FSLWNLIQLGIVSGERV--FKILDLESPQKQATIT 388 Query: 458 PSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 PN G+I + Y + P IL GI+ S++ G+ + +VG TG+GKST+I L + Sbjct: 389 KLPN--IKGNIRFEKVVFGYSADKP-ILTGIDFSVKHGDIVAIVGPTGAGKSTIINLLMK 445
>MSBA_NEIMA (Q9JW59) Lipid A export ATP-binding/permease protein msbA| Length = 621 Score = 53.5 bits (127), Expect = 5e-07 Identities = 42/144 (29%), Positives = 70/144 (48%), Gaps = 2/144 (1%) Frame = +2 Query: 218 ELIGTLVLSITAFLMISLPSNFIKK--EFVGMSLSYGLSLNSLVYFAISISCMLENDMVA 391 ELI ++ L++ F+ + N EF+ ++ L + + + +IS ++ +A Sbjct: 290 ELIASIALAVVIFIALWQSQNGYTTIGEFMAFIVAM-LQMYAPIKSLANISIPMQTMFLA 348 Query: 392 VERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGG 571 + V F P E + K P G I ++ V YR + L G N+ IR G Sbjct: 349 ADGVCAFLDTPPEQD--KGTLAPQR---VEGRISFRNVDVEYRSDGIKALDGFNLDIRQG 403 Query: 572 EKIGVVGRTGSGKSTLIQALFRLV 643 E++ +VGR+GSGKST++ L R V Sbjct: 404 ERVALVGRSGSGKSTVVNLLPRFV 427
>MDLB_BUCAI (P57552) Multidrug resistance-like ATP-binding protein mdlB (EC| 3.6.3.44) Length = 580 Score = 53.1 bits (126), Expect = 7e-07 Identities = 52/193 (26%), Positives = 83/193 (43%), Gaps = 4/193 (2%) Frame = +2 Query: 53 APVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLE---- 220 A + + F ET+ G I+ F ++ F QE + + SS Y GF L Sbjct: 201 AEINNKFNETINGMNVIQQFCQQRRF-QEKIKK--SSDLHYMSRMKILRLDGFLLRPLLS 257 Query: 221 LIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVER 400 L+ +++L FL P + + ++Y LN + +L+ +VA ER Sbjct: 258 LLSSMILCNFMFLFSFFPVGAFEVGVLYAFITYLGRLNEPLIAITIQQSVLQQSIVAGER 317 Query: 401 VNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKI 580 + P + K +D L S G I+I ++ ++ IL+ IN+ I + Sbjct: 318 IFSLIDSPKQKYGKNKDLLKS------GKINIQNVSFYHKNCNKNILENINIKISSKSFV 371 Query: 581 GVVGRTGSGKSTL 619 VG TGSGKSTL Sbjct: 372 AFVGHTGSGKSTL 384
>HLYB_ECO57 (Q46717) Alpha-hemolysin translocation ATP-binding protein hlyB| (EHEC-hlyB protein) Length = 706 Score = 53.1 bits (126), Expect = 7e-07 Identities = 33/84 (39%), Positives = 47/84 (55%) Frame = +2 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 ++VER+ P E KK P GDI+ +++ RY + +IL IN+ I Sbjct: 439 ISVERLGDVLNTPVE---KKSGRNILPE--IQGDIEFKNVRFRYSSDGNVILNNINLYIS 493 Query: 566 GGEKIGVVGRTGSGKSTLIQALFR 637 G+ IG+VGR+GSGKSTL + L R Sbjct: 494 KGDVIGIVGRSGSGKSTLTKLLQR 517
>Y1051_HAEIN (Q57180) Hypothetical ABC transporter ATP-binding protein HI1051| Length = 614 Score = 52.8 bits (125), Expect = 9e-07 Identities = 25/59 (42%), Positives = 38/59 (64%) Frame = +2 Query: 461 SPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 SP G+I +D+ Y P PL L N++I+ GEK+G++GR+G+GKST++ L R Sbjct: 355 SPLQVKQGEIKFNDITFAYDPTKPL-LNHFNLTIKPGEKVGLIGRSGAGKSTIVNLLLR 412
>LCNCL_LACLA (Q9CJB8) Lactococcin transport/processing ATP-binding protein| lcnC-like (EC 3.4.22.-) Length = 715 Score = 52.4 bits (124), Expect = 1e-06 Identities = 54/202 (26%), Positives = 100/202 (49%), Gaps = 7/202 (3%) Frame = +2 Query: 47 TKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELI 226 T A + E + G TI+ E E +Q+ S L+ F +E + ++ Sbjct: 339 TNAILNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKEAF-TLQQSEAIQTAIKTT 397 Query: 227 GTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLV-YFA------ISISCMLENDM 385 LVL++ L++ + + + + +L ++ N+L+ YF I++ L+ Sbjct: 398 VQLVLNV---LILWFGATLVMHQKI--TLGQLITFNALLSYFTNPITNIINLQTKLQKAR 452 Query: 386 VAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIR 565 VA ER+N+ +PSE E KK + S + ++++S++ +Y +L I +SI+ Sbjct: 453 VANERLNEVYLVPSEFEEKKTELSLS-----HFNLNMSEISYQYGFGRK-VLSEIKLSIK 506 Query: 566 GGEKIGVVGRTGSGKSTLIQAL 631 EK+ +VG +GSGKSTL++ L Sbjct: 507 ENEKLTIVGISGSGKSTLVKLL 528
>CYAB_BORPE (P18770) Cyclolysin secretion/processing ATP-binding protein cyaB| (EC 3.4.22.-) Length = 712 Score = 52.0 bits (123), Expect = 2e-06 Identities = 52/197 (26%), Positives = 93/197 (47%), Gaps = 9/197 (4%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDR-----INSSLRMYFHNYAANEWLGFRLELIGTLVL 241 ETV G T++ E ++ Q N DR + + L + AN + L+ VL Sbjct: 338 ETVSGIDTVKSLAVEPQW-QRNWDRQLAGYVAAGLSVANVAMLANTGVTLISRLVALGVL 396 Query: 242 SITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDM----VAVERVNQ 409 + A +++ ++ VG +++ + + I ++ L ND V+++R+ Sbjct: 397 WVGATEVVA------QRMTVGELVAFNMLSGHVTQPVIRLA-QLWNDFQQTGVSMQRLGD 449 Query: 410 FSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVV 589 +E K LP+ G I++ + RYRP+ L+ +++ I GE +GVV Sbjct: 450 ILNCRTEVAGDKAQ-LPA----LRGSIELDRVSFRYRPDAADALRNVSLRIAPGEVVGVV 504 Query: 590 GRTGSGKSTLIQALFRL 640 GR+GSGKSTL + + R+ Sbjct: 505 GRSGSGKSTLTRLIQRM 521
>Y288_THEMA (Q9WYC4) Hypothetical ABC transporter ATP-binding protein TM0288| Length = 598 Score = 52.0 bits (123), Expect = 2e-06 Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 10/221 (4%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 + R L +L G+ + E + G T I+ F +E E E DR+N SLR Sbjct: 205 FYENQRVLGQLNGIIE--------EDISGLTVIKLFTRE-EKEMEKFDRVNESLRKV--G 253 Query: 185 YAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKE----------FVGMSLSYGLSLN 334 A + G L+ +++ F +IS ++ + F+G S + LN Sbjct: 254 TKAQIFSGVLPPLMN--MVNNLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLN 311 Query: 335 SLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVR 514 L + M++ + + ER+ + L E K+D G+I+ ++ Sbjct: 312 ELS----NQFNMIQMALASAERIFEILDLEEE----KDDPDAVELREVRGEIEFKNVWFS 363 Query: 515 YRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 Y P +LK I I+ G+K+ +VG TGSGK+T++ L R Sbjct: 364 YDKKKP-VLKDITFHIKPGQKVALVGPTGSGKTTIVNLLMR 403
>MDLA_BUCBP (Q89A97) Multidrug resistance-like ATP-binding protein mdlA (EC| 3.6.3.44) Length = 579 Score = 51.6 bits (122), Expect = 2e-06 Identities = 50/199 (25%), Positives = 90/199 (45%), Gaps = 21/199 (10%) Frame = +2 Query: 110 FKKENEFFQENLDRINSSLRMYFHNYAANEWLGF----------------RLELIGTLVL 241 F N + QENL+ I+ NY + ++L + I L + Sbjct: 193 FSHLNNYAQENLNNIHMIKAFGLENYYSKKFLKIAHKTRKKNIKIAKIDSKFNPIIHLFI 252 Query: 242 SITAFLMISLPSNFIKKEFV--GMSLSYGLSLNSLVYFAISISCM---LENDMVAVERVN 406 SI+ L I++ S I + G +S+ L L +++ ++ + M +E + +R+ Sbjct: 253 SISHLLAITIGSYMITYNEISTGELMSFILYLGLIIWPMLAFAWMFNIIERGSASWDRIK 312 Query: 407 QFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGV 586 S + + K+ + N P G +++ +Y + ILK IN IR G+ +G+ Sbjct: 313 --SMINNNLFIHKKKYKNISNIP--GILEVKINYFKYSKSNKTILKNINFKIRPGQILGI 368 Query: 587 VGRTGSGKSTLIQALFRLV 643 G TGSGKSTL++ + R + Sbjct: 369 CGPTGSGKSTLLKLIQRQI 387
>MSBA_NEIMB (Q9JXR3) Lipid A export ATP-binding/permease protein msbA| Length = 621 Score = 51.2 bits (121), Expect = 3e-06 Identities = 41/144 (28%), Positives = 69/144 (47%), Gaps = 2/144 (1%) Frame = +2 Query: 218 ELIGTLVLSITAFLMISLPSNFIKK--EFVGMSLSYGLSLNSLVYFAISISCMLENDMVA 391 ELI ++ L++ F+ + N EF+ ++ L + + + +IS ++ +A Sbjct: 290 ELIASIALAVVIFIALWQSQNGYTTIGEFMAFIVAM-LQMYAPIKSLANISIPMQTMFLA 348 Query: 392 VERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGG 571 + V F P E + K P G I ++ V YR + L N+ IR G Sbjct: 349 ADGVCAFLDTPPEQD--KGTLAPQR---VEGRISFRNVDVEYRSDGIKALDNFNLDIRQG 403 Query: 572 EKIGVVGRTGSGKSTLIQALFRLV 643 E++ +VGR+GSGKST++ L R V Sbjct: 404 ERVALVGRSGSGKSTVVNLLPRFV 427
>LCN3_LACLA (P37608) Lacticin 481/lactococcin transport/processing ATP-binding| protein lcnDR3 (EC 3.4.22.-) Length = 691 Score = 50.4 bits (119), Expect = 4e-06 Identities = 36/122 (29%), Positives = 60/122 (49%), Gaps = 8/122 (6%) Frame = +2 Query: 302 GMSLSYG--LSLNSLVYFAISISCM------LENDMVAVERVNQFSTLPSEAEWKKEDHL 457 G+ L+ G +S+ L+ F IS +++ M + R++ + S+ + + Sbjct: 394 GIYLNQGNLVSIPDLIIFQSGISLFVSAVNQIQDVMFEISRLSIYGNKISDLLIENPQRI 453 Query: 458 PSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 + +N I + D+ Y N I IN SI+ GEKI +VG++GSGKSTL L Sbjct: 454 DNIEKHSNNAIILKDISYSYELNN-YIFNNINFSIKKGEKIAIVGKSGSGKSTLFNILLG 512 Query: 638 LV 643 L+ Sbjct: 513 LI 514
>Y4GM_RHISN (P55469) Probable ABC transporter ATP-binding protein y4gM| Length = 586 Score = 50.4 bits (119), Expect = 4e-06 Identities = 56/216 (25%), Positives = 93/216 (43%), Gaps = 9/216 (4%) Frame = +2 Query: 20 RELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLD--------RINSSLRMY 175 R++ LE + +I ET G ++ F E +F + +D R NS R+ Sbjct: 192 RKIMELEIASIGQIIQSVQETSTGIRIVKAFALE-DFMRRRMDKYIGDVERRANSIARLE 250 Query: 176 FHNYAANEWL-GFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFA 352 + E L GF + G + LS L + + L+Y + L Sbjct: 251 AASSPIMETLSGFAIA--GVIALSGVLVLQQGNTPGELMSFITALLLAYEPA-KRLARMR 307 Query: 353 ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTP 532 IS LE+ +V V + Q + P E +K +P P P G+I D+ Y+ N Sbjct: 308 IS----LESALVGVRMMYQLADHPIELT-EKNSAIPLPEGP--GEIRFKDVNFSYK-NGE 359 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 + + +NV+ G+ +VG +G+GKS++I + RL Sbjct: 360 RLFQNLNVTFPAGKTTALVGPSGAGKSSIINLIMRL 395
>MDR65_DROME (Q00748) Multidrug resistance protein homolog 65 (EC 3.6.3.44)| (P-glycoprotein 65) Length = 1302 Score = 48.1 bits (113), Expect = 2e-05 Identities = 23/59 (38%), Positives = 38/59 (64%), Gaps = 2/59 (3%) Frame = +2 Query: 467 NWPTNGDIDISDLKVRYRPNTPLIL--KGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 N+ GD++ D+ RY P+ P ++ +G+N+ IR G+ + +VG +G GKST +Q L R Sbjct: 398 NYGLRGDVEFQDVFFRY-PSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQR 455
>MAM1_SCHPO (P78966) Mating factor M secretion protein mam1 (Multiple drug| resistance protein homolog) (P-glycoprotein) Length = 1336 Score = 48.1 bits (113), Expect = 2e-05 Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 8/217 (3%) Frame = +2 Query: 5 YLATSRELTRLEGVTKAPVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN 184 Y+ S E + V I H +T+V TI+ + + FF+EN +SLR + Sbjct: 943 YIYVSTERMCQDVVISTTSILH--KTIVNLDTIKGYSVLS-FFRENH---KNSLRKSWEA 996 Query: 185 YAANE-WLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMS-LSYGLSLNSLVYFAIS 358 + W + +L+ + A L+ S FI KEF + + LSL + S Sbjct: 997 FKRRAFWTSLGFAINNSLLYFVRA-LLFYCSSIFISKEFYTVEQMVQVLSLATFTLLMAS 1055 Query: 359 ISCM----LENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPN 526 M + +A RV + S+L K +L +P G I+ + Y + Sbjct: 1056 TCIMSLPNVSASRIATSRVLKLSSL-KPGNLHKSGYL---KFPLVGKIEFDGVSFAYPDS 1111 Query: 527 --TPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L L +++SI EK+ +VG +GSGKSTL++ L Sbjct: 1112 ERNHLALNNVSLSIEAREKVAIVGISGSGKSTLVELL 1148 Score = 31.2 bits (69), Expect = 2.7 Identities = 15/33 (45%), Positives = 21/33 (63%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 L ++V I GE + ++G +GSGKST I L R Sbjct: 452 LINVSVFIPFGELVHIIGPSGSGKSTFISLLLR 484
>LAGD_LACLA (P59852) Lactococcin-G-processing and transport ATP-binding protein| lagD (EC 3.4.22.-) Length = 703 Score = 47.8 bits (112), Expect = 3e-05 Identities = 45/202 (22%), Positives = 94/202 (46%), Gaps = 7/202 (3%) Frame = +2 Query: 53 APVIDHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGT 232 A V E++ G TI+ + EN + DR++S + L + + Sbjct: 326 AEVNSSIIESLKGIETIKSYNGENHVY----DRVDSEFVTLMKKSFKSVTLDNVQQSLKM 381 Query: 233 LVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYF-------AISISCMLENDMVA 391 ++ I++ L++ L S+++ + SL ++ N+L+ F I++ ++ VA Sbjct: 382 VIELISSVLILWLGSSYVIDGKI--SLGQLITYNALLVFFTEPLQNIINLQVKMQKARVA 439 Query: 392 VERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGG 571 +R+N+ ++ E ++ ++ N DI + + Y P +L+ +++ I Sbjct: 440 NKRLNEIMSISPE---QRNTNINISKNIFNKDIKLDKVSFSYNMKLP-VLRDVSLEIYSK 495 Query: 572 EKIGVVGRTGSGKSTLIQALFR 637 K+ +VG +GSGKSTL + L + Sbjct: 496 SKVALVGVSGSGKSTLAKLLVK 517
>MSBA_FRANO (Q47908) Lipid A export ATP-binding/permease protein msbA| Length = 593 Score = 47.0 bits (110), Expect = 5e-05 Identities = 47/216 (21%), Positives = 94/216 (43%), Gaps = 10/216 (4%) Frame = +2 Query: 20 RELTRLEGVTKAPVIDHFTETVVGATTIRCF----KKENEFFQENLDRINSSLRMYFHNY 187 R L+R + V ET+ IR F K++N+FF+ NLD S Sbjct: 194 RNLSRNTQSSMGNVTHTAEETIRNYKEIRIFGAQQKQQNKFFK-NLDYTYSQ---QIRTI 249 Query: 188 AANEWLGFRLELIGTLVLSITAFLMISLPSN------FIKKEFVGMSLSYGLSLNSLVYF 349 A + +++I +LVL+ + F + +N ++ + ++ + Sbjct: 250 ALDALTSPVIQIIASLVLAFSLFTIAIFGTNDGGGSSWLTAGSFASFFAAAAAILKPIKN 309 Query: 350 AISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNT 529 ++ +++ + A E + P+E E ++ +G++ I DL + + Sbjct: 310 LTKVNVVIQKAVAATEDIFYILDYPAEKETGSKELAK-----VDGNVTIKDLSFAFGEHK 364 Query: 530 PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 +L G++V I+ G+ + VG++GSGK+TL + R Sbjct: 365 --VLSGVSVDIKAGQTVAFVGKSGSGKTTLTSIISR 398
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (EC 3.6.3.44)| (P-glycoprotein 1) (CD243 antigen) Length = 1280 Score = 47.0 bits (110), Expect = 5e-05 Identities = 49/207 (23%), Positives = 84/207 (40%), Gaps = 19/207 (9%) Frame = +2 Query: 77 ETVVGATTIRCF---KKENEFFQENLDR---------------INSSLRMYFHNYAANEW 202 E + T+ F KKE E + +NL+ I ++ + + +YA W Sbjct: 256 EVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFW 315 Query: 203 LGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLEND 382 G L L G + + S+ +G + S G + S+ FA + Sbjct: 316 YGTTLVLSGEYSIGQVLTVFFSV--------LIG-AFSVGQASPSIEAFANARGA----- 361 Query: 383 MVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL-ILKGINVS 559 A E PS + K H P G+++ ++ Y + ILKG+N+ Sbjct: 362 --AYEIFKIIDNKPSIDSYSKSGHKPDN---IKGNLEFRNVHFSYPSRKEVKILKGLNLK 416 Query: 560 IRGGEKIGVVGRTGSGKSTLIQALFRL 640 ++ G+ + +VG +G GKST +Q + RL Sbjct: 417 VQSGQTVALVGNSGCGKSTTVQLMQRL 443
>CYDC_ECOLI (P23886) Transport ATP-binding protein cydC| Length = 573 Score = 46.6 bits (109), Expect = 6e-05 Identities = 21/50 (42%), Positives = 32/50 (64%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 + + D++ Y + LKGI++ + GE I ++GRTG GKSTL+Q L R Sbjct: 339 LTLRDVQFTYPEQSQQALKGISLQVNAGEHIAILGRTGCGKSTLLQQLTR 388
>MDL1_CANAL (P97998) ATP-dependent permease MDL1| Length = 685 Score = 46.6 bits (109), Expect = 6e-05 Identities = 54/200 (27%), Positives = 91/200 (45%), Gaps = 13/200 (6%) Frame = +2 Query: 77 ETVVGATTIRCFKKE----NEFFQENLDRINSSLR---MYFHNYAANEWLG----FRLEL 223 E + G I+ F ++ + + QE + NSS+R + Y+ N ++G L + Sbjct: 306 EKLNGVKVIQTFSQQQSVVHSYNQEIKNIFNSSMREAKLAGFFYSTNGFIGNVTMIGLLI 365 Query: 224 IGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERV 403 +GT ++ + L S + + G S+ +GL + L + A ERV Sbjct: 366 MGTKLIGAGELTVGDLSSFMMYAVYTGTSV-FGLG---------NFYTELMKGIGAAERV 415 Query: 404 NQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL--ILKGINVSIRGGEK 577 + E + + +HL NGDI+ + Y P+ P I K +N+ I+ GE Sbjct: 416 FELV----EYQPRISNHLGKKVDELNGDIEFKGIDFTY-PSRPESGIFKDLNLHIKQGEN 470 Query: 578 IGVVGRTGSGKSTLIQALFR 637 + +VG +GSGKST+ Q L R Sbjct: 471 VCLVGPSGSGKSTVSQLLLR 490
>CBIO4_METAC (Q8TSC8) Putative cobalt import ATP-binding protein cbiO 4| Length = 641 Score = 46.2 bits (108), Expect = 8e-05 Identities = 23/45 (51%), Positives = 31/45 (68%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLI 622 I I DL Y N ++LKGIN+ IR GE++ ++G GSGKSTL+ Sbjct: 338 ISIRDLWSGYEKNR-MVLKGINLEIRKGERVAIMGTNGSGKSTLL 381 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/48 (45%), Positives = 29/48 (60%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I+I DL Y T LKG+N+ I GE + + G TG GKSTL++ L Sbjct: 10 IEIKDLWYTYPGRTEPTLKGVNLKIEEGEFVLLTGPTGCGKSTLLKTL 57
>CBIO5_METMA (Q8PVG9) Putative cobalt import ATP-binding protein cbiO 5| Length = 581 Score = 46.2 bits (108), Expect = 8e-05 Identities = 25/79 (31%), Positives = 43/79 (54%), Gaps = 3/79 (3%) Frame = +2 Query: 395 ERVNQFSTLPSEAEWKKEDHLPSPNWPTNGD---IDISDLKVRYRPNTPLILKGINVSIR 565 E++ + P +++ SP W + + + + DL Y + ++LKGIN+ I Sbjct: 284 EKIGDYPASPG-----RKEKTSSPGWSSENNEPLVSVRDLWSGY-DKSRMVLKGINLEIH 337 Query: 566 GGEKIGVVGRTGSGKSTLI 622 GE++ V+G GSGKSTL+ Sbjct: 338 RGERVAVMGTNGSGKSTLL 356 Score = 40.0 bits (92), Expect = 0.006 Identities = 21/48 (43%), Positives = 29/48 (60%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I+I DL Y LKGI++ I+ GE + + G TG GKSTL++ L Sbjct: 10 IEIRDLWYTYPGRAETTLKGIDLKIKEGEFVLLTGPTGCGKSTLLKTL 57
>Y1304_MYCBO (P0A4W5) Hypothetical ABC transporter ATP-binding protein Mb1304c| Length = 582 Score = 46.2 bits (108), Expect = 8e-05 Identities = 47/196 (23%), Positives = 85/196 (43%), Gaps = 12/196 (6%) Frame = +2 Query: 89 GATTIRCFKKE----NEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSITAF 256 G +R F +E ++F Q N N++L +A W L + TL ++ ++ Sbjct: 203 GVRVVRAFTREGYERDKFAQANTALSNAAL-------SAGNWQALMLP-VTTLTINASSV 254 Query: 257 LMI-----SLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTL 421 +I + S ++ + LSY + V A +L V ER+ + + Sbjct: 255 ALIWFGGLRIDSGQMQVGSLIAFLSYFAQILMAVLMATMTLAVLPRASVCAERITEVLST 314 Query: 422 PSEAEWKKEDHLPSPNWPTNGD---IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVG 592 P+ + +P +PT+G + ++ Y +L+ I+++ R G +VG Sbjct: 315 PAAL-----GNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQDISLTARPGTTTAIVG 369 Query: 593 RTGSGKSTLIQALFRL 640 TGSGKSTL+ + RL Sbjct: 370 STGSGKSTLVSLICRL 385
>Y1273_MYCTU (P0A4W4) Hypothetical ABC transporter ATP-binding protein| Rv1273c/MT1311 Length = 582 Score = 46.2 bits (108), Expect = 8e-05 Identities = 47/196 (23%), Positives = 85/196 (43%), Gaps = 12/196 (6%) Frame = +2 Query: 89 GATTIRCFKKE----NEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSITAF 256 G +R F +E ++F Q N N++L +A W L + TL ++ ++ Sbjct: 203 GVRVVRAFTREGYERDKFAQANTALSNAAL-------SAGNWQALMLP-VTTLTINASSV 254 Query: 257 LMI-----SLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTL 421 +I + S ++ + LSY + V A +L V ER+ + + Sbjct: 255 ALIWFGGLRIDSGQMQVGSLIAFLSYFAQILMAVLMATMTLAVLPRASVCAERITEVLST 314 Query: 422 PSEAEWKKEDHLPSPNWPTNGD---IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVG 592 P+ + +P +PT+G + ++ Y +L+ I+++ R G +VG Sbjct: 315 PAAL-----GNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQDISLTARPGTTTAIVG 369 Query: 593 RTGSGKSTLIQALFRL 640 TGSGKSTL+ + RL Sbjct: 370 STGSGKSTLVSLICRL 385
>CBIO2_ENTFA (Q839D4) Cobalt import ATP-binding protein cbiO 2| Length = 289 Score = 46.2 bits (108), Expect = 8e-05 Identities = 26/56 (46%), Positives = 33/56 (58%), Gaps = 3/56 (5%) Frame = +2 Query: 485 DIDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 DI + Y+PNTP L IN++I+ G +VG TGSGKSTL+Q L LV Sbjct: 2 DIRFKQVDFTYQPNTPFEQRALFDINLTIQDGSYTAIVGHTGSGKSTLLQHLNALV 57
>MESD_LEUME (Q10418) Mesentericin Y105 transport/processing ATP-binding protein| mesD (EC 3.4.22.-) Length = 722 Score = 45.8 bits (107), Expect = 1e-04 Identities = 47/188 (25%), Positives = 81/188 (43%), Gaps = 3/188 (1%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSITAF 256 E + G TI+ E + + + L F YA E + ++ + L L++ Sbjct: 354 EDINGVETIKALNSEATAYHKIDHEFVTYLEKSFV-YAKTEAVQNAIKSLLQLSLNVV-I 411 Query: 257 LMISLPSNFIKKEFVGMSLSYGLSLNSL---VYFAISISCMLENDMVAVERVNQFSTLPS 427 L + K VG ++Y L + I++ L+ VA R+N+ + S Sbjct: 412 LWVGAQLVMTNKISVGQLITYNALLGFFTDPLQNIINLQTKLQQASVANNRLNEVYLVDS 471 Query: 428 EAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSG 607 E K+ H + N + + +Y P I ++++I GEKI +VG +GSG Sbjct: 472 EF---KDSHQMTEKITPNSSLVADHITYKYGFGAPAI-DDVSLTITAGEKIALVGISGSG 527 Query: 608 KSTLIQAL 631 KSTL++ L Sbjct: 528 KSTLVKLL 535
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (EC 3.6.3.44)| (P-glycoprotein 2) (P-glycoprotein 3) Length = 1278 Score = 45.8 bits (107), Expect = 1e-04 Identities = 21/54 (38%), Positives = 35/54 (64%), Gaps = 1/54 (1%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ SD+ Y + ILKG+N+ ++ G+ + +VG +G GKST +Q L RL Sbjct: 389 GNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (EC 3.6.3.44)| (P-glycoprotein 2) Length = 1276 Score = 45.8 bits (107), Expect = 1e-04 Identities = 21/54 (38%), Positives = 35/54 (64%), Gaps = 1/54 (1%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ SD+ Y + ILKG+N+ ++ G+ + +VG +G GKST +Q L RL Sbjct: 389 GNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (EC 3.6.3.44)| (P-glycoprotein 1) (CD243 antigen) Length = 1276 Score = 45.8 bits (107), Expect = 1e-04 Identities = 43/174 (24%), Positives = 73/174 (41%), Gaps = 15/174 (8%) Frame = +2 Query: 164 LRMYFHNYAANEWLGFRLELIGTLVLSITAFLMI--SLPSNFIKKEFVGMSLSYGLSLNS 337 L Y +N + LG + + + + AFL+I S F + +S Y + Sbjct: 271 LERYNNNLEEAKRLGIKKAITANISMG-AAFLLIYASYALAFWYGTSLVISKEYSIGQVL 329 Query: 338 LVYFAI------------SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTN 481 V+FA+ +I A E N PS + K + P Sbjct: 330 TVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDN---IK 386 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ ++ Y + ILKG+N+ ++ G+ + +VG +G GKST +Q L RL Sbjct: 387 GNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRL 440 Score = 41.6 bits (96), Expect = 0.002 Identities = 19/54 (35%), Positives = 37/54 (68%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G++ +++ Y RP+ P +L+G+N+ ++ G+ + +VG +G GKST++Q L R Sbjct: 1030 GNVKFNEVVFNYPTRPDIP-VLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLER 1082
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (EC 3.6.3.44)| (P-glycoprotein 3) Length = 1281 Score = 45.4 bits (106), Expect = 1e-04 Identities = 21/54 (38%), Positives = 35/54 (64%), Gaps = 1/54 (1%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G++D SD+ Y + ILKG+N+ ++ G+ + +VG +G GK+T +Q L RL Sbjct: 392 GNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRL 445
>MSBA_PSEAE (Q9HUG8) Lipid A export ATP-binding/permease protein msbA| Length = 603 Score = 45.4 bits (106), Expect = 1e-04 Identities = 45/182 (24%), Positives = 76/182 (41%) Frame = +2 Query: 74 TETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSITA 253 +ET+ G +R F E + LD S+ L+L+ + ++I Sbjct: 224 SETIQGYRVVRSFGGEAYEEKRFLDASQSNTDKQLRMTKTGAVYTPMLQLVIYVAMAILM 283 Query: 254 FLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEA 433 FL++ L + + V + GL L + +S ++ + E + F L A Sbjct: 284 FLVLWLRGDASAGDLVAYITAAGL-LPKPIRQLSEVSSTVQRGVAGAESI--FEQLDEAA 340 Query: 434 EWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKS 613 E ED +G +++ +L RY +L I+ G+ I +VGR+GSGKS Sbjct: 341 E---EDQGTVEKERVSGRLEVRNLSFRYPGTDKQVLDDISFIAEPGQMIALVGRSGSGKS 397 Query: 614 TL 619 TL Sbjct: 398 TL 399
>CBIO4_BACHK (Q6HG98) Putative cobalt import ATP-binding protein cbiO 4| Length = 551 Score = 45.4 bits (106), Expect = 1e-04 Identities = 20/43 (46%), Positives = 30/43 (69%) Frame = +2 Query: 503 LKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + +Y N+PLIL+ + VSI GE + +VG+ G+GKSTL+ L Sbjct: 298 ISFQYEKNSPLILRDLTVSIEKGEWVALVGKNGTGKSTLLTLL 340
>YOJI_ECOLI (P33941) ABC transporter ATP-binding protein yojI| Length = 547 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/103 (30%), Positives = 54/103 (52%) Frame = +2 Query: 323 LSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISD 502 L L + + A+ L VA ++N+F+ P +AE+ + P NW T +++ + Sbjct: 273 LFLRTPLLSAVGALPTLLTAQVAFNKLNKFALAPFKAEFPRPQAFP--NWQT---LELRN 327 Query: 503 LKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + Y+ N + IN++I+ GE + ++G GSGKSTL L Sbjct: 328 VTFAYQDNA-FSVGPINLTIKRGELLFLIGGNGSGKSTLAMLL 369
>MCHF_ECOLI (Q9EXN5) Probable microcin H47 secretion/processing ATP-binding| protein mchF (EC 3.4.22.-) Length = 698 Score = 45.4 bits (106), Expect = 1e-04 Identities = 46/216 (21%), Positives = 96/216 (44%), Gaps = 12/216 (5%) Frame = +2 Query: 20 RELTRLEGVTKAPVIDHFTETVVGATTIRCFK----KENEFFQENLDRINSSLRMYFHNY 187 R+++ V A +F E++ G T++ + + +D INS +++ + Sbjct: 338 RQISEETLVRGARASSYFMESLYGIATVKIQGMAGIRGTHWLNLKIDAINSGIKLTKMDL 397 Query: 188 AANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGL-------SLNSLVY 346 F +L + A L+I + +GM +++G + SL Sbjct: 398 LFGGINTFVAACDQVAILWLGASLVID------NQMTIGMFVAFGSFRGQFSDRVASLTS 451 Query: 347 FAISISCM-LENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRP 523 F + + M L N+ +A +++ + E K E + + P + ++ +DL RY Sbjct: 452 FLLQLRIMSLHNERIADIALHE------KEEKKPEIEIVADMSPVS--LETTDLSYRYDS 503 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + + G+N+S+ GE + + G +G+GK+TL++ L Sbjct: 504 QSAQVFSGLNLSVAPGESVAITGASGAGKTTLMKVL 539
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (EC 3.6.3.44)| (P-glycoprotein A) Length = 1321 Score = 45.1 bits (105), Expect = 2e-04 Identities = 22/54 (40%), Positives = 35/54 (64%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI + ++ Y RP+ P IL+G+N+ + G+ + +VG +G GKST+I L R Sbjct: 414 GDITVENVHFTYPSRPDVP-ILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLR 466 Score = 34.7 bits (78), Expect = 0.25 Identities = 15/34 (44%), Positives = 24/34 (70%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 ILKG++ S+ G+ + +VG +G GKST++ L R Sbjct: 1094 ILKGLSFSVEPGQTLALVGPSGCGKSTVVALLER 1127
>YD01_SCHPO (O14286) Putative ABC transporter C15A10.01 in chromosome I| Length = 693 Score = 45.1 bits (105), Expect = 2e-04 Identities = 22/52 (42%), Positives = 31/52 (59%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G I ++ Y PN P IL G + +I G K+ VG +G GKST+++ LFR Sbjct: 441 GSIQFDNVHFSYNPNRP-ILNGCSFNIPAGAKVAFVGASGCGKSTILRLLFR 491
>HMT1_SCHPO (Q02592) Heavy metal tolerance protein precursor| Length = 830 Score = 45.1 bits (105), Expect = 2e-04 Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 5/114 (4%) Frame = +2 Query: 311 LSYGLSLNSLVYFAISISCMLENDMVAVERVNQ-FSTLPSEAEWKKEDHLPSPNWP---- 475 L+Y + L + F ++ L+N ++ ER+ + F P+ E PN P Sbjct: 528 LTYMIQLQQPLNFFGTLYRSLQNSIIDTERLLEIFEEKPTVVE--------KPNAPDLKV 579 Query: 476 TNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 T G + S + Y P P +L IN + G+ I +VG +G GKST+++ L R Sbjct: 580 TQGKVIFSHVSFAYDPRKP-VLSDINFVAQPGKVIALVGESGGGKSTIMRILLR 632
>CBIO3_BACC1 (Q734T1) Putative cobalt import ATP-binding protein cbiO 3| Length = 553 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/95 (31%), Positives = 48/95 (50%) Frame = +2 Query: 347 FAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPN 526 F + + M ND A+ VN+ P K+E L + + + +Y N Sbjct: 263 FTVREAQMKMNDFSAISYVNE----PIVQREKQEVILSAEH-----------ISFQYEKN 307 Query: 527 TPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +PLIL+ + VSI G+ + +VG+ G+GKSTL+ L Sbjct: 308 SPLILRDLTVSIEKGKWVALVGKNGTGKSTLLTIL 342
>CBIO1_MESFL (Q6F1W5) Cobalt import ATP-binding protein cbiO 1| Length = 406 Score = 44.7 bits (104), Expect = 2e-04 Identities = 20/48 (41%), Positives = 29/48 (60%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I + +LK +Y P+ P L ++ I GE + V+G GSGKSTL + L Sbjct: 139 IKVENLKFKYAPDFPYALNDVSFEINDGEYVAVIGHNGSGKSTLSKML 186
>PHNC_ALCFA (Q6WB63) Phosphonates import ATP-binding protein phnC (EC 3.6.3.28)| Length = 276 Score = 44.7 bits (104), Expect = 2e-04 Identities = 19/35 (54%), Positives = 30/35 (85%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 LKG+N+S++ GE +G++G +G+GKSTLI+ + RLV Sbjct: 18 LKGVNLSVQPGELLGLIGPSGAGKSTLIRCVNRLV 52
>CYDC_HAEIN (P45081) Transport ATP-binding protein cydC| Length = 576 Score = 44.7 bits (104), Expect = 2e-04 Identities = 20/50 (40%), Positives = 31/50 (62%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 I +L Y L+LK + + + G+KI ++G+TGSGKS+L+Q L R Sbjct: 338 ISAKNLNFSYPEQETLVLKNLTLDLEQGKKIAILGKTGSGKSSLLQLLVR 387
>PHNC_RHILO (Q98GF5) Phosphonates import ATP-binding protein phnC (EC 3.6.3.28)| Length = 284 Score = 44.7 bits (104), Expect = 2e-04 Identities = 22/56 (39%), Positives = 38/56 (67%) Frame = +2 Query: 476 TNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 ++ ++I + R+ NT + IN+SI G+ +GV+GR+G+GKSTL++ + RLV Sbjct: 3 SSATLEIRGVSRRFGKNTAV--SDINISIPQGQMVGVIGRSGAGKSTLLRMINRLV 56
>PHNC_WOLSU (Q7M8M4) Phosphonates import ATP-binding protein phnC (EC 3.6.3.28)| Length = 275 Score = 44.3 bits (103), Expect = 3e-04 Identities = 20/52 (38%), Positives = 38/52 (73%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + I +L RY+ + + LKG+++ I+ G+ +G++G +G+GKSTLI+ + RL+ Sbjct: 2 LKIENLTKRYKGDE-IALKGVSLEIKKGQVVGLIGPSGAGKSTLIRCINRLI 52
>BEXA_HAEIN (P10640) ATP-binding protein bexA| Length = 217 Score = 44.3 bits (103), Expect = 3e-04 Identities = 21/50 (42%), Positives = 35/50 (70%), Gaps = 2/50 (4%) Frame = +2 Query: 488 IDISDLKVRYRPNT--PLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I ++++ +Y N+ +LK IN ++ GEKIG++GR G+GKSTLI+ + Sbjct: 2 IRVNNVCKKYHTNSGWKTVLKNINFELQKGEKIGILGRNGAGKSTLIRLM 51
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (EC 3.6.3.44)| (P-glycoprotein 3) (MDR1A) Length = 1276 Score = 44.3 bits (103), Expect = 3e-04 Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 1/74 (1%) Frame = +2 Query: 422 PSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRT 598 PS + K H P G+++ ++ Y + ILKG+N+ ++ G+ + +VG + Sbjct: 369 PSIDSFSKSGHKPDN---IQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNS 425 Query: 599 GSGKSTLIQALFRL 640 G GKST +Q + RL Sbjct: 426 GCGKSTTVQLMQRL 439
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (EC 3.6.3.44)| (P-glycoprotein 2) Length = 1276 Score = 44.3 bits (103), Expect = 3e-04 Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 1/74 (1%) Frame = +2 Query: 422 PSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRT 598 PS + + H P G+++ ++ Y + + ILKG+N+ ++ G+ + +VG++ Sbjct: 372 PSIDSFSTQGHKPDS---VMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKS 428 Query: 599 GSGKSTLIQALFRL 640 G GKST +Q L RL Sbjct: 429 GCGKSTTVQLLQRL 442
>MSBA_ACIAD (Q6F9X0) Lipid A export ATP-binding/permease protein msbA| Length = 574 Score = 44.3 bits (103), Expect = 3e-04 Identities = 44/193 (22%), Positives = 84/193 (43%), Gaps = 6/193 (3%) Frame = +2 Query: 77 ETVVGATTIRCFKKEN----EFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLS 244 E++ G ++ F E F++ + D + L+M + + +L+ + +S Sbjct: 203 ESIGGQAVVKSFVGEEFEQKRFYKSSEDNLKRGLKMVIVQNLNSPLV----QLVMAMAMS 258 Query: 245 ITAFLMI--SLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFST 418 + +L + + EFV + GL L + ++ L+ + A V + Sbjct: 259 LIVWLALRPQILGETTAGEFVAYITAAGL-LAKPIKNLTDVNEKLQRGIAAAYSVFELLD 317 Query: 419 LPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRT 598 LPSE E+H + GD+ + + Y I K N++I GE + +VGR+ Sbjct: 318 LPSE-----ENH-GTQTPKLQGDVRFDHVTLEYAGQVKAI-KDFNLTIEPGETVAIVGRS 370 Query: 599 GSGKSTLIQALFR 637 G+GK++L+ L R Sbjct: 371 GAGKTSLVNLLVR 383
>Y664_HAEIN (Q57538) Probable ABC transporter ATP-binding protein HI0664| Length = 552 Score = 44.3 bits (103), Expect = 3e-04 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 3/194 (1%) Frame = +2 Query: 65 DHFTETVVGATTIRCF---KKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTL 235 D F ++V G I+ F K+ + Q+ +I+++ A + + Sbjct: 202 DFFLDSVRGMKEIQLFGYAKQRLDEIQQRSQKIDTAFERIKDQEAKVRVYTEVAVSVFNI 261 Query: 236 VLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFS 415 ++ T ++ SL +G+ L +S V ++S L + + ERV S Sbjct: 262 IMLFTGLILFSLDKIDFAAFLIGVILL--MSSYGPVIALSNLSSNLLQTLASGERV--LS 317 Query: 416 TLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGR 595 L E E K D + + ID+ ++ Y IL +++S++ GE +G+ GR Sbjct: 318 LLAEEPELK--DVESAVDLKDVSRIDVENVNFAYGEEQ--ILSDVSLSVKKGEILGIHGR 373 Query: 596 TGSGKSTLIQALFR 637 +GSGKSTL++ L R Sbjct: 374 SGSGKSTLLKLLMR 387
>MDR1_RAT (P43245) Multidrug resistance protein 1 (EC 3.6.3.44)| (P-glycoprotein 1) (CD243 antigen) Length = 1277 Score = 44.3 bits (103), Expect = 3e-04 Identities = 51/215 (23%), Positives = 90/215 (41%), Gaps = 6/215 (2%) Frame = +2 Query: 14 TSRELTRLEGVTKAPVIDHFTETVVGATTIRCF---KKENEFFQENLDRINSSLRMYFHN 184 TS L+ KA + E + T+ F KKE E + +NL+ R+ Sbjct: 236 TSFTNKELQAYAKAGAVAE--EVLAAIRTVIAFGGQKKELERYNKNLEEAK---RVGIKK 290 Query: 185 -YAANEWLGFRLELI-GTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAIS 358 AN +G L+ + L+ + L + + + + + S L S+ + A + Sbjct: 291 AITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPN 350 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL- 535 I A E PS + + H P G+++ ++ Y + + Sbjct: 351 IEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDS---IMGNLEFKNVYFNYPSRSEVK 407 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 ILKG+N+ ++ G+ + +VG +G GKST +Q L RL Sbjct: 408 ILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
>Y1303_MYCBO (P63398) Hypothetical ABC transporter ATP-binding protein Mb1303c| Length = 631 Score = 43.9 bits (102), Expect = 4e-04 Identities = 45/203 (22%), Positives = 82/203 (40%), Gaps = 13/203 (6%) Frame = +2 Query: 68 HFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEW-LGFRLELIGTLVLS 244 H ET G T ++ F + ++ R FH + + GF + + LV Sbjct: 261 HLEETYSGFTVVKTFGHQ------------AAARERFHELNDDVYQAGFGAQFLSGLVQP 308 Query: 245 ITAFLM------------ISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMV 388 TAF+ + + + I + + Y N + + L++ + Sbjct: 309 ATAFIGNLGYVAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVA 368 Query: 389 AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRG 568 + ERV P E+ + E LP+ G ++ + Y P TP+I + +++ Sbjct: 369 SAERVFDVLDEPEESP-EPEPELPN----LTGRVEFEHVNFAYLPGTPVI-RDLSLVAEP 422 Query: 569 GEKIGVVGRTGSGKSTLIQALFR 637 G + +VG TG+GK+TL+ L R Sbjct: 423 GSTVAIVGPTGAGKTTLVNLLMR 445
>Y1272_MYCTU (P63397) Hypothetical ABC transporter ATP-binding protein| Rv1272c/MT1310 Length = 631 Score = 43.9 bits (102), Expect = 4e-04 Identities = 45/203 (22%), Positives = 82/203 (40%), Gaps = 13/203 (6%) Frame = +2 Query: 68 HFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEW-LGFRLELIGTLVLS 244 H ET G T ++ F + ++ R FH + + GF + + LV Sbjct: 261 HLEETYSGFTVVKTFGHQ------------AAARERFHELNDDVYQAGFGAQFLSGLVQP 308 Query: 245 ITAFLM------------ISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMV 388 TAF+ + + + I + + Y N + + L++ + Sbjct: 309 ATAFIGNLGYVAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVA 368 Query: 389 AVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRG 568 + ERV P E+ + E LP+ G ++ + Y P TP+I + +++ Sbjct: 369 SAERVFDVLDEPEESP-EPEPELPN----LTGRVEFEHVNFAYLPGTPVI-RDLSLVAEP 422 Query: 569 GEKIGVVGRTGSGKSTLIQALFR 637 G + +VG TG+GK+TL+ L R Sbjct: 423 GSTVAIVGPTGAGKTTLVNLLMR 445
>CBIO1_THETN (Q8R7Y5) Cobalt import ATP-binding protein cbiO 1| Length = 286 Score = 43.9 bits (102), Expect = 4e-04 Identities = 24/51 (47%), Positives = 31/51 (60%), Gaps = 3/51 (5%) Frame = +2 Query: 488 IDISDLKVRYRPNTP---LILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I + ++ Y TP + LK IN SI E +G++G TGSGKSTLIQ L Sbjct: 3 IKVENVSFIYNEGTPYATVALKDINFSIDDEEFVGIIGHTGSGKSTLIQQL 53
>CBIO_VIBPA (Q87G35) Putative cobalt import ATP-binding protein cbiO| Length = 579 Score = 43.9 bits (102), Expect = 4e-04 Identities = 24/52 (46%), Positives = 31/52 (59%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ S+ RY LK IN+ I GEKI ++G +GSGKSTL Q L L+ Sbjct: 3 IEFSNFSFRYESLDKPTLKNINLRIEKGEKIVIIGPSGSGKSTLGQCLNGLI 54 Score = 34.3 bits (77), Expect = 0.32 Identities = 24/99 (24%), Positives = 43/99 (43%), Gaps = 6/99 (6%) Frame = +2 Query: 365 CMLENDMVAVERVNQFSTLPSEA------EWKKEDHLPSPNWPTNGDIDISDLKVRYRPN 526 C +E D + + +TLP E W P P +++ L Y Sbjct: 256 CAIEGDA----KPSSLTTLPLEQYKPTVQAWFDGSTAQPPKTPAETLLEVRGLTYSY-DG 310 Query: 527 TPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 L+ ++ I+ GE + V+G+ GSGKST+ + + ++ Sbjct: 311 EKNALEDVSFDIKRGEFVSVLGKNGSGKSTITKLIMGVI 349
>CBIO2_PYRHO (O59479) Putative cobalt import ATP-binding protein cbiO 2| Length = 284 Score = 43.5 bits (101), Expect = 5e-04 Identities = 21/52 (40%), Positives = 32/52 (61%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I++ D+ RY + L+ IN+ IR GE +G++G +GSGKST L L+ Sbjct: 4 IEVEDVSFRYGNSREYSLRHINLEIRKGEFLGIIGPSGSGKSTFCLTLNGLI 55
>CBIO2_SPIKU (Q6XYZ3) Cobalt import ATP-binding protein cbiO 2| Length = 305 Score = 43.5 bits (101), Expect = 5e-04 Identities = 24/52 (46%), Positives = 32/52 (61%), Gaps = 3/52 (5%) Frame = +2 Query: 479 NGDIDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQ 625 N DI +++ Y P TP L+ INV I+ G+ ++G TGSGKSTLIQ Sbjct: 15 NVDITFTNVSYVYSPKTPYEYTSLQDINVVIKPGKITAIIGSTGSGKSTLIQ 66
>CBIO4_BACAN (Q81N53) Putative cobalt import ATP-binding protein cbiO 4| Length = 551 Score = 43.5 bits (101), Expect = 5e-04 Identities = 19/43 (44%), Positives = 29/43 (67%) Frame = +2 Query: 503 LKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + +Y N PLIL+ + VSI G+ + +VG+ G+GKSTL+ L Sbjct: 298 ISFQYEKNNPLILRDLTVSIEKGKWVALVGKNGTGKSTLLTIL 340
>SPAT_BACSU (P33116) Subtilin transport ATP-binding protein spaT| Length = 614 Score = 43.5 bits (101), Expect = 5e-04 Identities = 37/139 (26%), Positives = 64/139 (46%) Frame = +2 Query: 215 LELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAV 394 ++L+G +++ I++ S F K VG +SY S++ + + SI + + + Sbjct: 269 VQLVGAVII------FIAIMSAFAGKIMVGNVMSYIRSVSLVQNHSQSIMTSIYSIYNSN 322 Query: 395 ERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGE 574 +NQ E K + H P + + ++ Y LK INVS+ GE Sbjct: 323 LYMNQLYEFLELKEEKSQGHKKPIVEPIHSVV-FQNVSFIYPNQGEQTLKHINVSLHKGE 381 Query: 575 KIGVVGRTGSGKSTLIQAL 631 ++ +VG GSGK T I+ L Sbjct: 382 RVAIVGPNGSGKKTFIKLL 400
>CBIO1_CLOPE (Q8XHV3) Cobalt import ATP-binding protein cbiO 1| Length = 285 Score = 43.5 bits (101), Expect = 5e-04 Identities = 24/51 (47%), Positives = 29/51 (56%), Gaps = 3/51 (5%) Frame = +2 Query: 488 IDISDLKVRYRPNTP---LILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I I +L Y P TP + L IN I GE + ++G TGSGKST IQ L Sbjct: 3 IKIENLNHIYMPKTPFEKIALNNINCEIEDGEFVALIGHTGSGKSTFIQHL 53
>LOLD_PSEPK (Q88KY4) Lipoprotein-releasing system ATP-binding protein lolD| Length = 227 Score = 43.5 bits (101), Expect = 5e-04 Identities = 17/37 (45%), Positives = 27/37 (72%) Frame = +2 Query: 521 PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 P + +L G+N+ +R GE++ +VG +GSGKSTL+ L Sbjct: 20 PESVQVLSGLNLELRAGERVAIVGSSGSGKSTLLNLL 56
>NIST_LACLA (Q03203) Nisin transport ATP-binding protein nisT| Length = 600 Score = 43.1 bits (100), Expect = 7e-04 Identities = 42/166 (25%), Positives = 71/166 (42%), Gaps = 6/166 (3%) Frame = +2 Query: 152 INSSLRMYFHNYAANEWLGFRLELIGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSL 331 IN L + N +L F L LI +L+I A ++ + V + + + Sbjct: 245 INQDLAIARKKTYFNIFLDFILNLIN--ILTIFAMILSVRAGKLLIGNLVSLIQAIS-KI 301 Query: 332 NSLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKED------HLPSPNWPTNGDID 493 N+ I ++ N + +E++ +F S K ED H+ G + Sbjct: 302 NTYSQTMIQNIYIIYNTSLFMEQLFEFLKRESVVHKKIEDTEICNQHI--------GTVK 353 Query: 494 ISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 + +L Y + LK IN+S GE +VG+ GSGKSTL++ + Sbjct: 354 VINLSYVYPNSNAFALKNINLSFEKGELTAIVGKNGSGKSTLVKII 399
>CBIO2_METTH (O27739) Putative cobalt import ATP-binding protein cbiO 2| Length = 311 Score = 43.1 bits (100), Expect = 7e-04 Identities = 20/44 (45%), Positives = 29/44 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 I++ DL Y TP L+GIN+ + GE++ V+G G+GKSTL Sbjct: 2 IELRDLSYSYPDGTPA-LRGINMKVERGERVAVIGPNGAGKSTL 44
>CBIO3_LACJO (Q74I62) Putative cobalt import ATP-binding protein cbiO 3| Length = 573 Score = 43.1 bits (100), Expect = 7e-04 Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 7/91 (7%) Frame = +2 Query: 380 DMVAVERVNQFSTLPSE-------AEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLI 538 ++ +++ V+Q STLP A W K+ + + + + +Y N P Sbjct: 260 NLSSIKEVDQISTLPVSEKISDKLAAWTKQAKITKKEVDNLPLLKLDHVGHQYSKNQPYP 319 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 LK ++ +I G+ I +VG+ G+GK+TL + + Sbjct: 320 LKDVSTTINQGDFISIVGQNGAGKTTLCRTI 350 Score = 40.4 bits (93), Expect = 0.005 Identities = 21/52 (40%), Positives = 29/52 (55%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ D +Y LK IN+ I GEKI + G +GSGKST+ + L L+ Sbjct: 6 IEFKDFSFKYNSQAEPTLKNINLKINKGEKILLAGPSGSGKSTIGRCLNGLI 57
>MSBA_HAEIN (P44407) Lipid A export ATP-binding/permease protein msbA| Length = 587 Score = 43.1 bits (100), Expect = 7e-04 Identities = 26/94 (27%), Positives = 49/94 (52%) Frame = +2 Query: 356 SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL 535 +++ ++ M A + + F+ L E E K+D P G+++ ++ Y+ L Sbjct: 308 AVNAQFQSGMAACQTL--FAILDLEPE--KDDGAYKAE-PAKGELEFKNVSFAYQGKDEL 362 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 L I+ S+ G+ + +VGR+GSGKST+ + R Sbjct: 363 ALNNISFSVPAGKTVALVGRSGSGKSTIANLVTR 396
>TAP2_HUMAN (Q03519) Antigen peptide transporter 2 (APT2) (Peptide transporter| TAP2) (Peptide transporter PSF2) (Peptide supply factor 2) (PSF-2) (Peptide transporter involved in antigen processing 2) Length = 686 Score = 43.1 bits (100), Expect = 7e-04 Identities = 51/198 (25%), Positives = 87/198 (43%), Gaps = 11/198 (5%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHN--YAANEWLGFRLELIGTLVLSIT 250 E V G T+R F E + + ++Y+ A L R+ +G +L ++ Sbjct: 334 EAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLS 393 Query: 251 AFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSE 430 L + + + Y S+ S V + I + +++ A E+V + Sbjct: 394 CGLQQMQDGELTQGSLLSFMI-YQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMD---- 448 Query: 431 AEWKKEDHLPSPNW--PTN--GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVG 592 ++ +LPSP PT G + D+ Y RP+ P +LKG+ ++R GE +VG Sbjct: 449 ----RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVG 503 Query: 593 RTGSGKST---LIQALFR 637 GSGKST L+Q L++ Sbjct: 504 PNGSGKSTVAALLQNLYQ 521
>CBIO1_STRCO (Q9KXJ6) Putative cobalt import ATP-binding protein cbiO 1| Length = 563 Score = 42.7 bits (99), Expect = 0.001 Identities = 24/75 (32%), Positives = 43/75 (57%), Gaps = 1/75 (1%) Frame = +2 Query: 422 PSEAEWKKEDHLP-SPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRT 598 P + W++ P +P+ PT ++ L VR + L+ +++++ GE + ++GR Sbjct: 294 PVTSRWRRRGKRPENPSAPTPYAAEVRSLAVRR--DRVQALRHVDLTVSPGETVALMGRN 351 Query: 599 GSGKSTLIQALFRLV 643 G+GKSTL+ AL LV Sbjct: 352 GAGKSTLLSALVGLV 366
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (EC 3.6.3.44)| (P-glycoprotein 3) Length = 1279 Score = 42.7 bits (99), Expect = 0.001 Identities = 19/54 (35%), Positives = 35/54 (64%), Gaps = 1/54 (1%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ +D+ Y + ILKG+N+ ++ G+ + +VG +G GKST +Q + RL Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445
>CBIO_VIBVY (Q7MFH3) Putative cobalt import ATP-binding protein cbiO| Length = 574 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/52 (44%), Positives = 31/52 (59%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ S+ RY L+ IN+ I GEKI ++G +GSGKSTL Q L L+ Sbjct: 3 IEFSNFSFRYESLDKPTLRNINLRIEKGEKIVIIGPSGSGKSTLGQCLNGLI 54 Score = 35.4 bits (80), Expect = 0.15 Identities = 17/71 (23%), Positives = 40/71 (56%) Frame = +2 Query: 431 AEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGK 610 A+W + + S + + +D+ +L Y L+G++ +++ GE + ++G+ GSGK Sbjct: 280 ADWFHQANTTSNHIRSETLLDVRNLTYSY-DGEKNALEGVSFNVQRGEFVSILGKNGSGK 338 Query: 611 STLIQALFRLV 643 ST+ + + ++ Sbjct: 339 STITKLIMGVI 349
>CBIO_VIBVU (Q8D3Z9) Cobalt import ATP-binding protein cbiO| Length = 574 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/52 (44%), Positives = 31/52 (59%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ S+ RY L+ IN+ I GEKI ++G +GSGKSTL Q L L+ Sbjct: 3 IEFSNFSFRYESLDKPTLRNINLRIEKGEKIVIIGPSGSGKSTLGQCLNGLI 54 Score = 35.4 bits (80), Expect = 0.15 Identities = 17/71 (23%), Positives = 40/71 (56%) Frame = +2 Query: 431 AEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGK 610 A+W + + S + + +D+ +L Y L+G++ +++ GE + ++G+ GSGK Sbjct: 280 ADWFHQANTTSNHIRSETLLDVRNLTYSY-DGEKNALEGVSFNVQRGEFVSILGKNGSGK 338 Query: 611 STLIQALFRLV 643 ST+ + + ++ Sbjct: 339 STITKLIMGVI 349
>CBIO1_CLOAB (Q97EK9) Cobalt import ATP-binding protein cbiO 1| Length = 286 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/51 (45%), Positives = 29/51 (56%), Gaps = 3/51 (5%) Frame = +2 Query: 488 IDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I I +L Y P TP L +N++I GE +G TGSGKSTLIQ + Sbjct: 3 IKIENLTYTYMPGTPFEKKALDNVNITIEDGEFAVFIGHTGSGKSTLIQQI 53
>CBIO2_METMA (Q8PY26) Cobalt import ATP-binding protein cbiO 2| Length = 287 Score = 42.7 bits (99), Expect = 0.001 Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 3/49 (6%) Frame = +2 Query: 488 IDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQ 625 I + ++ V Y NTPL LK +N+ I GE +G++G G+GKSTLI+ Sbjct: 3 IILENISVFYSRNTPLEISALKDVNLRIEKGEFVGILGEKGAGKSTLIK 51
>MDLA_BUCAI (P57551) Multidrug resistance-like ATP-binding protein mdlA (EC| 3.6.3.44) Length = 589 Score = 42.7 bits (99), Expect = 0.001 Identities = 32/116 (27%), Positives = 56/116 (48%), Gaps = 3/116 (2%) Frame = +2 Query: 299 VGMSLSYGLSLNSLVYFAISISCM---LENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN 469 +G S+ + L +++ ++++ M +E A +R++ E K + P P Sbjct: 274 IGQLTSFIMYLGLMIWPMLALAWMFNIVERGSAAWDRIHSIINKKLYIEDGKNNIPPYP- 332 Query: 470 WPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G ++I+ K Y N LK I + I+ G +G+ G TGSGKSTL+ + R Sbjct: 333 ----GILNINIKKFYYPNNQKPSLKDIRILIKPGNTLGICGPTGSGKSTLLMLIQR 384
>CBIO1_SPIKU (Q6XYZ4) Cobalt import ATP-binding protein cbiO 1| Length = 288 Score = 42.7 bits (99), Expect = 0.001 Identities = 17/44 (38%), Positives = 29/44 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 + ++D++ RYR N P + G++ I GE + ++G GSGKST+ Sbjct: 20 LKLTDVEFRYRENHPNAVDGVSFEINHGEYVTIIGHNGSGKSTI 63
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (EC 3.6.3.44)| (P-glycoprotein 1) (CD243 antigen) Length = 1276 Score = 42.4 bits (98), Expect = 0.001 Identities = 18/54 (33%), Positives = 35/54 (64%), Gaps = 1/54 (1%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 G+++ ++ Y + + ILKG+N+ ++ G+ + +VG +G GKST +Q + RL Sbjct: 389 GNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 442
>CBIO2_TREDE (Q73P93) Putative cobalt import ATP-binding protein cbiO 2| Length = 491 Score = 42.4 bits (98), Expect = 0.001 Identities = 20/44 (45%), Positives = 31/44 (70%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 + + D+ YR NT +LKGI++SI G+KI ++G+ G GK+TL Sbjct: 267 LTLHDIHFGYRKNTE-VLKGIHLSIYPGDKIALIGKNGCGKTTL 309
>CYDC_BACSU (P94366) Transport ATP-binding protein cydC| Length = 567 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/195 (21%), Positives = 83/195 (42%), Gaps = 6/195 (3%) Frame = +2 Query: 65 DHFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLS 244 +HF +++ G T+R F ++ +N+ ++ Y R+ + + L Sbjct: 193 NHFVDSLRGLETLR-FLGLSKSHSKNIFYVSE-------RYRKATMSTLRVAFLSSFALD 244 Query: 245 ITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE--NDMVAV----ERVN 406 L ++ + F+ + + G +L +L+ + E ND A E Sbjct: 245 FFTMLSVATVAVFLGLRLIDGDILLGPALTALILAPEYFLPVREVGNDYHATLNGQEAGK 304 Query: 407 QFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGV 586 + S+ +K+E L W ++ +S + V + I++S +G +KIG+ Sbjct: 305 TIQEILSQPGFKEETPLQLEAWSDQDELKLSGVSVGRS------VSDIHLSFKGKKKIGI 358 Query: 587 VGRTGSGKSTLIQAL 631 +G +G+GKSTLI L Sbjct: 359 IGASGAGKSTLIDIL 373
>MDR_PLAFF (P13568) Multidrug resistance protein (EC 3.6.3.44) (Chloroquine| resistance protein) Length = 1419 Score = 42.4 bits (98), Expect = 0.001 Identities = 23/54 (42%), Positives = 31/54 (57%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G +DI D+ RY RPN P I K ++ + + +VG TGSGKST + L R Sbjct: 1124 GKVDIKDVNFRYISRPNVP-IYKNLSFTCDSKKTTAIVGETGSGKSTFMNLLLR 1176
>MSBA_VIBCH (Q9KQW9) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 42.4 bits (98), Expect = 0.001 Identities = 19/53 (35%), Positives = 31/53 (58%) Frame = +2 Query: 479 NGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 NG++D+ D+ Y+ L ++ SI G+ + +VGR+GSGKST+ R Sbjct: 339 NGEVDVKDVTFTYQGKEKPALSHVSFSIPQGKTVALVGRSGSGKSTIANLFTR 391
>MSBA_ECOLI (P60752) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 42.4 bits (98), Expect = 0.001 Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 6/147 (4%) Frame = +2 Query: 215 LELIGTLVLSITAF------LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE 376 ++LI +L L+ + +M SL + I F M ++ L SL +++ + Sbjct: 255 IQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSM-IALMRPLKSLT----NVNAQFQ 309 Query: 377 NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 M A + + F+ L SE E +D GD++ ++ Y L+ IN+ Sbjct: 310 RGMAACQTL--FTILDSEQE---KDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINL 364 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFR 637 I G+ + +VGR+GSGKST+ + R Sbjct: 365 KIPAGKTVALVGRSGSGKSTIASLITR 391
>MSBA_ECOL6 (Q8FJB1) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 42.4 bits (98), Expect = 0.001 Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 6/147 (4%) Frame = +2 Query: 215 LELIGTLVLSITAF------LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE 376 ++LI +L L+ + +M SL + I F M ++ L SL +++ + Sbjct: 255 IQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSM-IALMRPLKSLT----NVNAQFQ 309 Query: 377 NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 M A + + F+ L SE E +D GD++ ++ Y L+ IN+ Sbjct: 310 RGMAACQTL--FTILDSEQE---KDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINL 364 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFR 637 I G+ + +VGR+GSGKST+ + R Sbjct: 365 KIPAGKTVALVGRSGSGKSTIASLITR 391
>MSBA_ECO57 (P60753) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 42.4 bits (98), Expect = 0.001 Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 6/147 (4%) Frame = +2 Query: 215 LELIGTLVLSITAF------LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE 376 ++LI +L L+ + +M SL + I F M ++ L SL +++ + Sbjct: 255 IQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSM-IALMRPLKSLT----NVNAQFQ 309 Query: 377 NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 M A + + F+ L SE E +D GD++ ++ Y L+ IN+ Sbjct: 310 RGMAACQTL--FTILDSEQE---KDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINL 364 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFR 637 I G+ + +VGR+GSGKST+ + R Sbjct: 365 KIPAGKTVALVGRSGSGKSTIASLITR 391
>PHNC1_OCEIH (Q8ESM5) Phosphonates import ATP-binding protein phnC 1 (EC| 3.6.3.28) Length = 258 Score = 42.4 bits (98), Expect = 0.001 Identities = 24/52 (46%), Positives = 34/52 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ D+ + Y PN LK INV I GE + +VG +G+GKST I+++ RLV Sbjct: 2 IEFKDVGLVY-PNGTEGLKNINVKINDGEFVVIVGLSGAGKSTFIRSINRLV 52
>CBIO3_STRMU (Q93D97) Putative cobalt import ATP-binding protein cbiO 3| Length = 558 Score = 42.0 bits (97), Expect = 0.002 Identities = 20/51 (39%), Positives = 32/51 (62%) Frame = +2 Query: 491 DISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 DI L Y P ILK ++ ++ GE++ +VG+ G+GKSTL +AL + + Sbjct: 296 DIQHLNFAYSSERP-ILKNLSFTLNKGERLAIVGKNGAGKSTLAKALCQFI 345 Score = 38.5 bits (88), Expect = 0.017 Identities = 18/44 (40%), Positives = 26/44 (59%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 I+ D +Y LK I +SI GEK+ ++G +GSGKST+ Sbjct: 5 IEFKDFSFKYDAQAEPTLKEITLSIEKGEKVLIIGPSGSGKSTI 48
>CBIO3_ENTFA (Q832R5) Putative cobalt import ATP-binding protein cbiO 3| Length = 568 Score = 42.0 bits (97), Expect = 0.002 Identities = 21/52 (40%), Positives = 32/52 (61%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I ++ +Y + LKGI ++I GEK+ +VG +GSGKSTL Q + L+ Sbjct: 6 ITFNNFSFQYHSQSEPTLKGIQLTIYEGEKVLIVGPSGSGKSTLAQCINGLI 57 Score = 37.0 bits (84), Expect = 0.050 Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 2/101 (1%) Frame = +2 Query: 323 LSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGD--IDI 496 L + ++ Y I ++ + D +A V+ + LP +W + PS G + + Sbjct: 249 LYVTAMKYAGIDLTQVSHLDKLA--EVSGETVLPKMTQWSVQ---PSSVSAVKGAELLRL 303 Query: 497 SDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 + +Y + +L +V+I GE I +VG+ G+GKSTL Sbjct: 304 EQVSYQYDRHGEKVLDDFSVTIHHGEMISIVGKNGAGKSTL 344
>CBIO7_METAC (Q8TK65) Putative cobalt import ATP-binding protein cbiO 7| Length = 453 Score = 42.0 bits (97), Expect = 0.002 Identities = 22/48 (45%), Positives = 31/48 (64%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++ LK Y P+ + L+GIN+ I+ G+KI VG+ GSGKSTL L Sbjct: 4 LETRGLKYTY-PDGTVALQGINIEIKKGKKIAFVGQNGSGKSTLFLLL 50
>CBIO3_STRR6 (Q8DQY5) Putative cobalt import ATP-binding protein cbiO 3| Length = 560 Score = 42.0 bits (97), Expect = 0.002 Identities = 22/48 (45%), Positives = 30/48 (62%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I+ D RY L+GI+++I GEK+ +VG +GSGKSTL Q L Sbjct: 6 IEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGSGKSTLGQCL 53 Score = 41.2 bits (95), Expect = 0.003 Identities = 18/32 (56%), Positives = 26/32 (81%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ILK +++ I+ GEKI +VG+ G+GKSTL +AL Sbjct: 311 ILKSLHLDIKKGEKIAIVGKNGAGKSTLAKAL 342
>CBIO3_STRPN (Q97SA3) Putative cobalt import ATP-binding protein cbiO 3| Length = 560 Score = 42.0 bits (97), Expect = 0.002 Identities = 22/48 (45%), Positives = 30/48 (62%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I+ D RY L+GI+++I GEK+ +VG +GSGKSTL Q L Sbjct: 6 IEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGSGKSTLGQCL 53 Score = 40.4 bits (93), Expect = 0.005 Identities = 17/32 (53%), Positives = 26/32 (81%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ILK +++ I+ GEKI +VG+ G+GKSTL +A+ Sbjct: 311 ILKSLHLDIKKGEKIAIVGKNGAGKSTLAKAI 342
>PHNC2_BACHD (Q9KFL0) Phosphonates import ATP-binding protein phnC 2 (EC| 3.6.3.28) Length = 244 Score = 42.0 bits (97), Expect = 0.002 Identities = 23/50 (46%), Positives = 34/50 (68%) Frame = +2 Query: 494 ISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 + LK Y P+ + +K IN SIR GE I V+G +G+GKST ++++ RLV Sbjct: 5 VEGLKKVY-PDGTVGIKEINTSIRRGELISVIGPSGAGKSTFLRSINRLV 53
>ABC1_ENCCU (Q8SQI5) Probable ABC transporter ECU01_0200/ECU01_1410| Length = 596 Score = 42.0 bits (97), Expect = 0.002 Identities = 16/40 (40%), Positives = 28/40 (70%) Frame = +2 Query: 521 PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 P + +L G++ I GE++G++GR GSGKST+++ + L Sbjct: 377 PRSAHVLSGVSFRIMRGERVGIIGRPGSGKSTILRLILML 416
>YEJF_ECOLI (P33916) Hypothetical ABC transporter ATP-binding protein yejF| Length = 529 Score = 42.0 bits (97), Expect = 0.002 Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 9/74 (12%) Frame = +2 Query: 449 DHLPSPNWPTNGDIDISDLKVRYRPNTPL---------ILKGINVSIRGGEKIGVVGRTG 601 D +P P P + +D+ L+V + + ++K I+ ++R GE +G+VG +G Sbjct: 264 DPVPLPE-PASTLLDVEQLQVAFPIRKGILKRIVDHNVVVKNISFTLRAGETLGLVGESG 322 Query: 602 SGKSTLIQALFRLV 643 SGKST AL RL+ Sbjct: 323 SGKSTTGLALLRLI 336
>ABCBB_HUMAN (O95342) Bile salt export pump (ATP-binding cassette sub-family B| member 11) Length = 1321 Score = 41.6 bits (96), Expect = 0.002 Identities = 25/54 (46%), Positives = 33/54 (61%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G ID D K Y RP++ +L G++VSI G+ + VG +G GKST IQ L R Sbjct: 1076 GKIDFVDCKFTYPSRPDSQ-VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLER 1128 Score = 35.4 bits (80), Expect = 0.15 Identities = 20/54 (37%), Positives = 33/54 (61%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTP--LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G+I+ ++ Y P+ P IL +N+ I+ GE +VG +G+GKST +Q + R Sbjct: 418 GEIEFHNVTFHY-PSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQR 470
>LOLD_NEIMA (P57030) Lipoprotein-releasing system ATP-binding protein lolD| Length = 231 Score = 41.6 bits (96), Expect = 0.002 Identities = 17/33 (51%), Positives = 25/33 (75%) Frame = +2 Query: 533 LILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L+L G+++ IR GE G++G +GSGKSTL+ L Sbjct: 23 LVLHGLDLEIRAGESTGIIGSSGSGKSTLLHIL 55
>PHNC1_BACHD (Q9KFN9) Phosphonates import ATP-binding protein phnC 1 (EC| 3.6.3.28) Length = 257 Score = 41.6 bits (96), Expect = 0.002 Identities = 19/41 (46%), Positives = 30/41 (73%) Frame = +2 Query: 521 PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 PN + L IN++I GE + +VG +G+GKSTL++A+ RL+ Sbjct: 12 PNGVIGLDNINLTIEKGEFVAIVGLSGAGKSTLLRAMNRLI 52
>MDLA_ECOLI (P77265) Multidrug resistance-like ATP-binding protein mdlA (EC| 3.6.3.44) Length = 590 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/116 (24%), Positives = 58/116 (50%), Gaps = 3/116 (2%) Frame = +2 Query: 299 VGMSLSYGLSLNSLVYFAISISCM---LENDMVAVERVNQFSTLPSEAEWKKEDHLPSPN 469 +G S+ + L +++ ++++ M +E A R+ + +EA + P P Sbjct: 274 LGQLTSFMMYLGLMIWPMLALAWMFNIVERGSAAYSRIR---AMLAEAPVVNDGSEPVPE 330 Query: 470 WPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G++D++ + Y L+ +N +++ G+ +G+ G TGSGKSTL+ + R Sbjct: 331 G--RGELDVNIHQFTYPQTDHPALENVNFALKPGQMLGICGPTGSGKSTLLSLIQR 384
>CBIO1_MYCMO (Q6KHL2) Cobalt import ATP-binding protein cbiO 1| Length = 308 Score = 41.6 bits (96), Expect = 0.002 Identities = 19/51 (37%), Positives = 33/51 (64%), Gaps = 3/51 (5%) Frame = +2 Query: 488 IDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 I++ ++ + P +P+ LKG+++S GE I ++G TGSGK+T I+ L Sbjct: 3 IEVKNISKVFEPKSPIEFTALKGVSLSFEQGEFISIIGPTGSGKTTFIEHL 53
>MSBA_SALTY (P63359) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 41.6 bits (96), Expect = 0.002 Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 6/147 (4%) Frame = +2 Query: 215 LELIGTLVLSITAF------LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE 376 ++LI +L L+ + +M SL + I F M ++ L SL +++ + Sbjct: 255 IQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSM-IALMRPLKSLT----NVNAQFQ 309 Query: 377 NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 M A + + F+ L SE E + + GD++ ++ Y L+ IN+ Sbjct: 310 RGMAACQTL--FAILDSEQEKDEGKRVIDR---ATGDLEFRNVTFTYPGREVPALRNINL 364 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFR 637 I G+ + +VGR+GSGKST+ + R Sbjct: 365 KIPAGKTVALVGRSGSGKSTIASLITR 391
>MSBA_SALTI (P63360) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 41.6 bits (96), Expect = 0.002 Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 6/147 (4%) Frame = +2 Query: 215 LELIGTLVLSITAF------LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE 376 ++LI +L L+ + +M SL + I F M ++ L SL +++ + Sbjct: 255 IQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSM-IALMRPLKSLT----NVNAQFQ 309 Query: 377 NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 M A + + F+ L SE E + + GD++ ++ Y L+ IN+ Sbjct: 310 RGMAACQTL--FAILDSEQEKDEGKRVIDR---ATGDLEFRNVTFTYPGREVPALRNINL 364 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFR 637 I G+ + +VGR+GSGKST+ + R Sbjct: 365 KIPAGKTVALVGRSGSGKSTIASLITR 391
>MSBA_SHIFL (Q83LP0) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 41.2 bits (95), Expect = 0.003 Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 6/147 (4%) Frame = +2 Query: 215 LELIGTLVLSITAF------LMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE 376 ++LI +L L+ + +M +L + I F M ++ L SL +++ + Sbjct: 255 IQLIASLALAFVLYAASFPSVMDNLTAGTITVVFSSM-IALMRPLKSLT----NVNAQFQ 309 Query: 377 NDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINV 556 M A + + F+ L SE E +D GD++ ++ Y L+ IN+ Sbjct: 310 RGMAACQTL--FTILDSEQE---KDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINL 364 Query: 557 SIRGGEKIGVVGRTGSGKSTLIQALFR 637 I G+ + +VGR+GSGKST+ + R Sbjct: 365 KIPAGKTVALVGRSGSGKSTIASLITR 391
>CBIO1_METJA (Q58488) Putative cobalt import ATP-binding protein cbiO 1| Length = 279 Score = 41.2 bits (95), Expect = 0.003 Identities = 19/44 (43%), Positives = 29/44 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 ++ DL RY P+ +LKGIN ++ GE + ++G G+GKSTL Sbjct: 4 VETKDLYFRY-PDGTAVLKGINFKVKKGEMVSLLGPNGAGKSTL 46
>CBIO_PHOPR (Q6LQ00) Putative cobalt import ATP-binding protein cbiO| Length = 564 Score = 41.2 bits (95), Expect = 0.003 Identities = 23/52 (44%), Positives = 32/52 (61%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ S+ +Y LK IN++I GEK+ +VG +GSGKSTL Q L L+ Sbjct: 3 IEFSNFTFKYWALEKPTLKNINLTIGKGEKVVIVGPSGSGKSTLGQCLNGLI 54
>HST6_CANAL (P53706) ATP-dependent permease HST6 (STE6 homolog)| Length = 1323 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLIL--KGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 I +++ Y P IL K I++ ++ IG+VG++GSGKST+++ LFRL Sbjct: 1035 ISFNNVSFSYPNKLPYILQLKSISLDVKKFTTIGIVGQSGSGKSTILKILFRL 1087 Score = 30.8 bits (68), Expect = 3.6 Identities = 15/39 (38%), Positives = 25/39 (64%) Frame = +2 Query: 524 NTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 N+ IL+ ++ I + V+G++GSGKST+ + L RL Sbjct: 386 NSVAILQDVSFGILQNQFNYVIGKSGSGKSTIAKLLMRL 424
>ABCB7_HUMAN (O75027) ATP-binding cassette sub-family B member 7, mitochondrial| precursor (ATP-binding cassette transporter 7) (ABC transporter 7 protein) Length = 752 Score = 41.2 bits (95), Expect = 0.003 Identities = 16/34 (47%), Positives = 26/34 (76%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 +L GI+ + G+K+ +VG +GSGKST+++ LFR Sbjct: 487 VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFR 520
>CBIO3_STRA5 (Q8DY60) Putative cobalt import ATP-binding protein cbiO 3| Length = 558 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/44 (47%), Positives = 29/44 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 I+ D +Y + LKGIN+SI GEK+ ++G +GSGKSTL Sbjct: 5 IEWKDFTFQYDVQSEPTLKGINLSIPKGEKVLILGPSGSGKSTL 48 Score = 32.0 bits (71), Expect = 1.6 Identities = 12/35 (34%), Positives = 24/35 (68%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 L ++ + G+++ +VG+ G+GKSTL +AL + + Sbjct: 311 LDDVSFDLYKGQRLAIVGKNGAGKSTLAKALCQFI 345
>CBIO3_STRA3 (Q8E3S6) Putative cobalt import ATP-binding protein cbiO 3| Length = 558 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/44 (47%), Positives = 29/44 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 I+ D +Y + LKGIN+SI GEK+ ++G +GSGKSTL Sbjct: 5 IEWKDFTFQYDVQSEPTLKGINLSIPKGEKVLILGPSGSGKSTL 48 Score = 32.0 bits (71), Expect = 1.6 Identities = 12/35 (34%), Positives = 24/35 (68%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 L ++ + G+++ +VG+ G+GKSTL +AL + + Sbjct: 311 LDDVSFDLYKGQRLAIVGKNGAGKSTLAKALCQFI 345
>PHNC2_OCEIH (Q8CUY0) Phosphonates import ATP-binding protein phnC 2 (EC| 3.6.3.28) Length = 254 Score = 41.2 bits (95), Expect = 0.003 Identities = 18/52 (34%), Positives = 35/52 (67%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 +++++L Y +T +LK +N I GE + ++G +G+GKSTL++ + R+V Sbjct: 4 LEVNNLGKHYNGDTK-VLKNVNFEIGSGEFVSIIGPSGAGKSTLLRCINRMV 54
>CBIO3_METAC (Q8TTN2) Putative cobalt import ATP-binding protein cbiO 3| Length = 444 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/48 (43%), Positives = 32/48 (66%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++ +DLK Y P+ L ++ +++SI G+KI +VG GSGKSTL L Sbjct: 7 LETTDLKYTY-PDGTLAIEDVSISIEKGKKIALVGPNGSGKSTLFLLL 53
>CBIO1_METMA (Q8PY27) Cobalt import ATP-binding protein cbiO 1| Length = 274 Score = 41.2 bits (95), Expect = 0.003 Identities = 21/44 (47%), Positives = 29/44 (65%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTL 619 I + ++ Y TP L IN++IR GE +G++GR GSGKSTL Sbjct: 2 IRLENVSYCYPDGTPA-LTNINLTIRKGEYLGIIGRNGSGKSTL 44
>MDR49_DROME (Q00449) Multidrug resistance protein homolog 49 (EC 3.6.3.44)| (P-glycoprotein 49) Length = 1302 Score = 41.2 bits (95), Expect = 0.003 Identities = 23/56 (41%), Positives = 35/56 (62%), Gaps = 2/56 (3%) Frame = +2 Query: 476 TNGDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 + GDI ++ Y R TP IL+G+N++I+ + +VG +GSGKST +Q L R Sbjct: 1055 SEGDIVYENVGFEYPTRKGTP-ILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLR 1109 Score = 41.2 bits (95), Expect = 0.003 Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 2/56 (3%) Frame = +2 Query: 476 TNGDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 T G I ++ RY RP+ ILKG+ V + G+ + VG +G GKSTLIQ + R Sbjct: 398 TAGHIRFEGIRFRYPARPDVE-ILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQR 452
>CBIO1_CLOTE (Q890R3) Cobalt import ATP-binding protein cbiO 1| Length = 288 Score = 41.2 bits (95), Expect = 0.003 Identities = 24/49 (48%), Positives = 29/49 (59%), Gaps = 3/49 (6%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGI---NVSIRGGEKIGVVGRTGSGKSTLIQ 625 I I +L Y TP K I N+ I+ GE I ++G TGSGKSTLIQ Sbjct: 3 IKIENLTHVYMQETPFEKKAIDDVNLEIKNGEFIALIGHTGSGKSTLIQ 51
>MSBA_RALSO (Q8XXB6) Lipid A export ATP-binding/permease protein msbA| Length = 592 Score = 40.8 bits (94), Expect = 0.003 Identities = 19/52 (36%), Positives = 31/52 (59%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GD+ + RY P+ L I++ ++ GE + +VG +GSGK+TL+ L R Sbjct: 347 GDLRFEHVTFRYGPDGRAALDSIDLHVKAGEIVALVGPSGSGKTTLVNLLPR 398
>CBIO8_METAC (Q8TI15) Putative cobalt import ATP-binding protein cbiO 8| Length = 283 Score = 40.8 bits (94), Expect = 0.003 Identities = 21/49 (42%), Positives = 31/49 (63%), Gaps = 3/49 (6%) Frame = +2 Query: 488 IDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQ 625 I + ++ Y NTPL LK +N+ I GE +G++G G+GKSTLI+ Sbjct: 3 IILENVSFFYSKNTPLETAALKDVNLRIEKGEFVGILGEKGAGKSTLIK 51
>MSBA_COXBU (Q83D84) Lipid A export ATP-binding/permease protein msbA| Length = 589 Score = 40.8 bits (94), Expect = 0.003 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 1/94 (1%) Frame = +2 Query: 359 ISCMLENDMVAVERVNQFSTLPSEAEWKK-EDHLPSPNWPTNGDIDISDLKVRYRPNTPL 535 ++ ++ + A E + F L + E + E HL G I+ + Y + Sbjct: 301 VNSYIQKGIAAAESI--FKLLDEDVEKDRGERHLVR----ARGAIEYQGVSFAYDNSKKT 354 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 IL I+ SI G+ + +VGR+G+GKSTLI L R Sbjct: 355 ILSEISFSIEPGQMVAIVGRSGAGKSTLINLLPR 388
>MDR20_ARATH (Q9LSJ5) Putative multidrug resistance protein 20 (P-glycoprotein| 18) Length = 1225 Score = 40.8 bits (94), Expect = 0.003 Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 2/110 (1%) Frame = +2 Query: 314 SYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDID 493 S G SL++L YF+ + + E M + RV + E + ++ T G+++ Sbjct: 299 SLGQSLSNLKYFSEAF-VVGERIMKVINRVPGIDSDNLEGQILEK---------TRGEVE 348 Query: 494 ISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 + +K Y RP TP I + + + G+ + +VG +GSGKST+I L R Sbjct: 349 FNHVKFTYPSRPETP-IFDDLCLRVPSGKTVALVGGSGSGKSTVISLLQR 397 Score = 35.0 bits (79), Expect = 0.19 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTP--LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G I S++ Y P P +I + ++ I G+ +VG +GSGKST+I + R Sbjct: 978 GQISFSNVDFAY-PTRPDVIIFQNFSIDIEDGKSTAIVGPSGSGKSTIISLIER 1030
>ABCB7_RAT (Q704E8) ATP-binding cassette sub-family B member 7, mitochondrial| precursor (ATP-binding cassette transporter 7) (ABC transporter 7 protein) Length = 752 Score = 40.8 bits (94), Expect = 0.003 Identities = 15/34 (44%), Positives = 26/34 (76%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 +L G++ + G+K+ +VG +GSGKST+++ LFR Sbjct: 487 VLSGVSFEVPAGKKVAIVGGSGSGKSTIVRLLFR 520
>RFBB_MYXXA (Q50863) O-antigen export system ATP-binding protein rfbB| Length = 437 Score = 40.8 bits (94), Expect = 0.003 Identities = 16/31 (51%), Positives = 26/31 (83%) Frame = +2 Query: 539 LKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 L+GIN++I G+ +G++GR GSGKSTL++ + Sbjct: 52 LRGINLTIPKGKTVGIIGRNGSGKSTLLKLI 82
>MSBA_YERPS (Q66CI3) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 40.8 bits (94), Expect = 0.003 Identities = 29/94 (30%), Positives = 44/94 (46%) Frame = +2 Query: 356 SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL 535 +++ + M A + + FS L E E K E L GDI+ + Y Sbjct: 303 NVNTQFQRGMAACQTL--FSILDMEQE-KDEGKLEVER--AKGDIEFRHVTFYYPGKDTP 357 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 L IN+ + G+ + +VGR+GSGKST+ L R Sbjct: 358 ALNDINIHLEAGKTVALVGRSGSGKSTIANLLTR 391
>MSBA_YERPE (Q8ZGA9) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 40.8 bits (94), Expect = 0.003 Identities = 29/94 (30%), Positives = 44/94 (46%) Frame = +2 Query: 356 SISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPL 535 +++ + M A + + FS L E E K E L GDI+ + Y Sbjct: 303 NVNTQFQRGMAACQTL--FSILDMEQE-KDEGKLEVER--AKGDIEFRHVTFYYPGKDTP 357 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 L IN+ + G+ + +VGR+GSGKST+ L R Sbjct: 358 ALNDINIHLEAGKTVALVGRSGSGKSTIANLLTR 391
>PHNC3_BACHD (Q9K8N1) Phosphonates import ATP-binding protein phnC 3 (EC| 3.6.3.28) Length = 258 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/52 (42%), Positives = 35/52 (67%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I+ ++ + Y PN LK +N+ I GE + +VG +G+GKSTLI+++ RLV Sbjct: 2 IEFKNVSLVY-PNGTQGLKDVNLKINEGEFVVIVGLSGAGKSTLIRSMNRLV 52
>ABCB7_MOUSE (Q61102) ATP-binding cassette sub-family B member 7, mitochondrial| (ATP-binding cassette transporter 7) (ABC transporter 7 protein) (Fragment) Length = 694 Score = 40.8 bits (94), Expect = 0.003 Identities = 15/34 (44%), Positives = 26/34 (76%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 +L G++ + G+K+ +VG +GSGKST+++ LFR Sbjct: 429 VLNGVSFEVPAGKKVAIVGGSGSGKSTIVRLLFR 462
>MSBA_ERWCT (Q6D437) Lipid A export ATP-binding/permease protein msbA| Length = 582 Score = 40.4 bits (93), Expect = 0.005 Identities = 19/52 (36%), Positives = 30/52 (57%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G+++ + Y L LK IN+ I G+ + +VGR+GSGKST+ + R Sbjct: 340 GELEFRQVNFAYPARENLALKNINLHIPVGKTVALVGRSGSGKSTIASLITR 391
>LOLD_AQUAE (O66646) Lipoprotein-releasing system ATP-binding protein lolD| Length = 224 Score = 40.4 bits (93), Expect = 0.005 Identities = 17/32 (53%), Positives = 26/32 (81%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ILKGI++S++ GE + ++G +GSGKSTL+ L Sbjct: 19 ILKGISLSVKKGEFVSIIGASGSGKSTLLYIL 50
>CBIO2_OCEIH (Q8ETV6) Cobalt import ATP-binding protein cbiO 2| Length = 289 Score = 40.4 bits (93), Expect = 0.005 Identities = 20/52 (38%), Positives = 31/52 (59%), Gaps = 3/52 (5%) Frame = +2 Query: 485 DIDISDLKVRYRPNTPL---ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 DI ++ Y+ NTP ++ ++ +I G + ++G TGSGKSTLIQ L Sbjct: 2 DISFKNVSYIYQENTPFEHRAIEDLSFTIGSGSIVAIIGHTGSGKSTLIQHL 53
>PHNC_BDEBA (Q6MIP7) Phosphonates import ATP-binding protein phnC (EC 3.6.3.28)| Length = 261 Score = 40.4 bits (93), Expect = 0.005 Identities = 20/40 (50%), Positives = 27/40 (67%) Frame = +2 Query: 521 PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 PN LK IN+ + GE + V+G +GSGKSTL++ L RL Sbjct: 18 PNGVQALKNINLEVHPGEFLVVIGLSGSGKSTLLRCLNRL 57
>MDR9_ARATH (Q9M0M2) Multidrug resistance protein 9 (P-glycoprotein 9)| Length = 1323 Score = 40.4 bits (93), Expect = 0.005 Identities = 21/54 (38%), Positives = 35/54 (64%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI++ D+ RY RP+ I G ++ + G+ + +VG++GSGKST+I + R Sbjct: 353 GDIELKDVYFRYPARPDVQ-IFAGFSLFVPNGKTVALVGQSGSGKSTVISLIER 405 Score = 38.5 bits (88), Expect = 0.017 Identities = 21/55 (38%), Positives = 34/55 (61%), Gaps = 2/55 (3%) Frame = +2 Query: 479 NGDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 NGDI+ + RY RP+ I + + ++I G+ + +VG +GSGKST+I + R Sbjct: 1032 NGDIEFRHVSFRYPMRPDVQ-IFRDLCLTIPSGKTVALVGESGSGKSTVISMIER 1085
>MDR17_ARATH (Q9M1Q9) Multidrug resistance protein 17 (P-glycoprotein 21)| Length = 1292 Score = 40.4 bits (93), Expect = 0.005 Identities = 23/54 (42%), Positives = 35/54 (64%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTP--LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI++ + +Y P+ P I + + +SIR G+ I +VG +GSGKST+I L R Sbjct: 1046 GDIELRHISFKY-PSRPDVQIFQDLCLSIRAGKTIALVGESGSGKSTVIALLQR 1098 Score = 40.0 bits (92), Expect = 0.006 Identities = 20/54 (37%), Positives = 35/54 (64%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI+++++ Y RP I +G ++SI G + +VG++GSGKST++ + R Sbjct: 401 GDIELNNVNFSYPARPEEQ-IFRGFSLSISSGSTVALVGQSGSGKSTVVSLIER 453
>CBIO1_BACSU (P40735) Cobalt import ATP-binding protein cbiO 1| Length = 281 Score = 40.4 bits (93), Expect = 0.005 Identities = 21/53 (39%), Positives = 32/53 (60%), Gaps = 1/53 (1%) Frame = +2 Query: 488 IDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I + D+ RYR + L G+++ + GE + +VG GSGKSTL +AL L+ Sbjct: 7 ISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHNGSGKSTLARALNGLI 59
>PEB1C_CAMJE (P45677) Probable ABC transporter ATP-binding protein PEB1C| Length = 242 Score = 40.0 bits (92), Expect = 0.006 Identities = 16/32 (50%), Positives = 26/32 (81%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LK IN+S++ GEK+ ++G +GSGKST I+ + Sbjct: 16 VLKNINLSVKEGEKLVIIGPSGSGKSTTIRCM 47
>CBIO2_LACPL (Q88XV1) Cobalt import ATP-binding protein cbiO 2| Length = 295 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/55 (41%), Positives = 30/55 (54%), Gaps = 3/55 (5%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKG---INVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I + Y+P TP K INV+I G ++G TGSGKSTL+Q L L+ Sbjct: 3 ITFKQVDFTYQPGTPFETKALTDINVTIPTGSYTALIGHTGSGKSTLLQHLNALL 57
>OPPF_ECOLI (P77737) Oligopeptide transport ATP-binding protein oppF| Length = 334 Score = 40.0 bits (92), Expect = 0.006 Identities = 22/63 (34%), Positives = 34/63 (53%), Gaps = 11/63 (17%) Frame = +2 Query: 488 IDISDLKVRYR-----------PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALF 634 ++I+DLKV + P T + G+ + + GE +GVVG +G GKST +A+ Sbjct: 12 LEIADLKVHFEIKDGKQWFWQPPKTLKAVDGVTLRLYEGETLGVVGESGCGKSTFARAII 71 Query: 635 RLV 643 LV Sbjct: 72 GLV 74
>PEDD_PEDAC (P36497) Pediocin PA-1 transport/processing ATP-binding protein| pedD (EC 3.4.22.-) (Pediocin AcH transport ATP-binding protein papD) Length = 724 Score = 40.0 bits (92), Expect = 0.006 Identities = 35/116 (30%), Positives = 64/116 (55%), Gaps = 7/116 (6%) Frame = +2 Query: 305 MSLSYGLSLNSLV-YFA------ISISCMLENDMVAVERVNQFSTLPSEAEWKKEDHLPS 463 +SL L+ N+L+ YF I++ L+ VA R+N+ + E+E+ K + + Sbjct: 421 LSLGQLLTYNALLAYFLTPLENIINLQPKLQAARVANNRLNEVYLV--ESEFSKSREITA 478 Query: 464 PNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 NGDI+++ + Y + IL+ ++++I +KI +VG +GSGK+TL + L Sbjct: 479 LE-QLNGDIEVNHVSFNYGYCSN-ILEDVSLTIPHHQKITIVGMSGSGKTTLAKLL 532
>MDR7_ARATH (Q9FHF1) Multidrug resistance protein 7 (P-glycoprotein 7)| Length = 1248 Score = 40.0 bits (92), Expect = 0.006 Identities = 20/54 (37%), Positives = 36/54 (66%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI++ D+ RY RP+ + + G ++++ G + +VG++GSGKST+I + R Sbjct: 355 GDIELRDVYFRYPARPDVQIFV-GFSLTVPNGMTVALVGQSGSGKSTVISLIER 407 Score = 38.1 bits (87), Expect = 0.022 Identities = 21/55 (38%), Positives = 34/55 (61%), Gaps = 2/55 (3%) Frame = +2 Query: 479 NGDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 +GDI++ + RY RP+ I + ++I G+ + +VG +GSGKST+I L R Sbjct: 1002 HGDIELQHVSFRYPMRPDIQ-IFSDLCLTISSGQTVALVGESGSGKSTVISLLER 1055
>YFIC_BACSU (P54719) Hypothetical ABC transporter ATP-binding protein yfiC| Length = 604 Score = 40.0 bits (92), Expect = 0.006 Identities = 50/205 (24%), Positives = 91/205 (44%), Gaps = 15/205 (7%) Frame = +2 Query: 68 HFTETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVLSI 247 + E+V GA I+ + +E + E L++ N++L+ + A GF +++ +L + Sbjct: 228 YIEESVSGAKVIKAYSREKQITAEFLEK-NAALKT--SGFWAQTISGFIPKVMNSL--NN 282 Query: 248 TAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLE--NDMVAVERVNQFSTL 421 +F MI+ +L +S+ S+V FA ND+ NQF+T+ Sbjct: 283 LSFTMIAAIGGLF-------ALKGWISIGSIVVFAEYSRQFTRPLNDLA-----NQFNTM 330 Query: 422 PS------------EAEWKKEDHLPSPNWPTN-GDIDISDLKVRYRPNTPLILKGINVSI 562 S + + ++ED + + P G I+ D+ Y LK + ++ Sbjct: 331 LSAIAGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQT-LKHLQFTV 389 Query: 563 RGGEKIGVVGRTGSGKSTLIQALFR 637 G+ I VG TG+GK+T+ L R Sbjct: 390 PAGQSIAFVGPTGAGKTTVTNLLAR 414
>CBIO3_STAAR (Q6GDC0) Putative cobalt import ATP-binding protein cbiO 3| Length = 570 Score = 40.0 bits (92), Expect = 0.006 Identities = 21/52 (40%), Positives = 27/52 (51%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I D +Y L+ INV I GEK+ VVG +GSGKST + L+ Sbjct: 6 ISFKDFSFQYHSQATPTLQNINVDIYPGEKVLVVGASGSGKSTFANCINGLI 57 Score = 34.3 bits (77), Expect = 0.32 Identities = 13/48 (27%), Positives = 31/48 (64%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++++++ V+Y + +L + +++ E + +VG G+GKSTL +A+ Sbjct: 304 LELNEVCVQYSDYSNSVLNNVQLNVYRREMLSIVGHNGAGKSTLAKAI 351
>CBIO3_STAAN (Q7A342) Putative cobalt import ATP-binding protein cbiO 3| Length = 570 Score = 40.0 bits (92), Expect = 0.006 Identities = 21/52 (40%), Positives = 27/52 (51%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I D +Y L+ INV I GEK+ VVG +GSGKST + L+ Sbjct: 6 ISFKDFSFQYHSQATPTLQNINVDIYPGEKVLVVGASGSGKSTFANCINGLI 57 Score = 34.3 bits (77), Expect = 0.32 Identities = 13/48 (27%), Positives = 31/48 (64%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++++++ V+Y + +L + +++ E + +VG G+GKSTL +A+ Sbjct: 304 LELNEVCVQYSDYSNSVLNNVQLNVYRREMLSIVGHNGAGKSTLAKAI 351
>CBIO3_STAAM (Q99QV7) Putative cobalt import ATP-binding protein cbiO 3| Length = 570 Score = 40.0 bits (92), Expect = 0.006 Identities = 21/52 (40%), Positives = 27/52 (51%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I D +Y L+ INV I GEK+ VVG +GSGKST + L+ Sbjct: 6 ISFKDFSFQYHSQATPTLQNINVDIYPGEKVLVVGASGSGKSTFANCINGLI 57 Score = 34.3 bits (77), Expect = 0.32 Identities = 13/48 (27%), Positives = 31/48 (64%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++++++ V+Y + +L + +++ E + +VG G+GKSTL +A+ Sbjct: 304 LELNEVCVQYSDYSNSVLNNVQLNVYRREMLSIVGHNGAGKSTLAKAI 351
>CBIO3_STAAC (Q5HCL3) Putative cobalt import ATP-binding protein cbiO 3| Length = 570 Score = 40.0 bits (92), Expect = 0.006 Identities = 21/52 (40%), Positives = 27/52 (51%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRLV 643 I D +Y L+ INV I GEK+ VVG +GSGKST + L+ Sbjct: 6 ISFKDFSFQYHSQATPTLQNINVDIYPGEKVLVVGASGSGKSTFANCINGLI 57 Score = 34.3 bits (77), Expect = 0.32 Identities = 13/48 (27%), Positives = 31/48 (64%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 ++++++ V+Y + +L + +++ E + +VG G+GKSTL +A+ Sbjct: 304 LELNEVCVQYSDYSNSVLNNVQLNVYRREMLSIVGHNGAGKSTLAKAI 351
>AOTP_PSEAE (O30506) Arginine/ornithine transport ATP-binding protein aotP| Length = 254 Score = 40.0 bits (92), Expect = 0.006 Identities = 16/48 (33%), Positives = 33/48 (68%) Frame = +2 Query: 488 IDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +++ DL RY + +LKG++++ + G+ I ++G +GSGKST ++ + Sbjct: 4 LEVQDLHKRYGSHE--VLKGVSLAAKAGDVISIIGSSGSGKSTFLRCI 49
>EXP8_STRPN (P35598) Putative ABC transporter ATP-binding protein exp8| (Exported protein 8) Length = 583 Score = 40.0 bits (92), Expect = 0.006 Identities = 50/203 (24%), Positives = 77/203 (37%), Gaps = 16/203 (7%) Frame = +2 Query: 77 ETVVGATTIRCFKKENEFFQENLDRINSSLRMYFHNYAANEWLGFR-----LELIGTLVL 241 E + G I+ F +E Q D IN +Y + A + L R L+L+G VL Sbjct: 206 ENIEGIRIIQAFNQEKRL-QAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVL 264 Query: 242 SITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTL 421 F S G+++ ++ F I+ + + +E FSTL Sbjct: 265 MAY---------------FGYRGFSIGITVGTMYAFIQYINRLFDP---LIEVTQNFSTL 306 Query: 422 PSEAE-----WKKEDHLPSPNWPTNGDIDISDLKVRYR------PNTPLILKGINVSIRG 568 + + D NG + + +R+ IL I+ S+ Sbjct: 307 QTAMVSAGRVFALIDERTYEPLQENGQAKVQEGNIRFEHVCFSYDGKHPILDDISFSVNK 366 Query: 569 GEKIGVVGRTGSGKSTLIQALFR 637 GE I VG TGSGKS++I L R Sbjct: 367 GETIAFVGHTGSGKSSIINVLMR 389
>LOLD_RALSO (Q8Y0C6) Lipoprotein-releasing system ATP-binding protein lolD| Length = 244 Score = 40.0 bits (92), Expect = 0.006 Identities = 16/32 (50%), Positives = 25/32 (78%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +L+G+++ I GEK+ +VG +GSGKSTL+ L Sbjct: 41 VLRGVDIRIGVGEKVAIVGASGSGKSTLLHVL 72
>PHNC_MYCMS (Q6MUF4) Phosphonates import ATP-binding protein phnC (EC 3.6.3.28)| Length = 250 Score = 39.7 bits (91), Expect = 0.008 Identities = 16/40 (40%), Positives = 28/40 (70%) Frame = +2 Query: 521 PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 PN +LK IN+ I GE + V+G +G+GK+TL++ + ++ Sbjct: 12 PNGKQVLKNINLEINKGELVAVIGLSGAGKTTLLKTINKI 51
>MSBA_PSESM (Q87VF3) Lipid A export ATP-binding/permease protein msbA| Length = 600 Score = 39.7 bits (91), Expect = 0.008 Identities = 46/192 (23%), Positives = 78/192 (40%), Gaps = 4/192 (2%) Frame = +2 Query: 74 TETVVGATTIRCFKKE----NEFFQENLDRINSSLRMYFHNYAANEWLGFRLELIGTLVL 241 +ET+ G +R F E N F + + LRM L +L+ + Sbjct: 221 SETIQGYRVVRSFGGEAYEQNRFAEASDSNTRKQLRMTKTGAIYTPML----QLVIYSAM 276 Query: 242 SITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERVNQFSTL 421 ++ FL++ L + + V + GL L + +S ++ + E + F L Sbjct: 277 AVLMFLVLFLRGDATAGDLVAYITAAGL-LPKPIRQLSEVSSTIQKGVAGAESI--FEQL 333 Query: 422 PSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTG 601 E E D +G +++ +L Y +L I+ S G+ I +VGR+G Sbjct: 334 DVEEE---VDTGTIELDRVSGHLEVKNLSFFYPQTERQVLNDISFSAAPGQMIALVGRSG 390 Query: 602 SGKSTLIQALFR 637 SGKSTL + R Sbjct: 391 SGKSTLANLIPR 402
>MDR5_ARATH (Q9SYI3) Putative multidrug resistance protein 5 (P-glycoprotein 5)| Length = 1230 Score = 39.7 bits (91), Expect = 0.008 Identities = 19/53 (35%), Positives = 33/53 (62%), Gaps = 1/53 (1%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPL-ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI++ + Y+ + + + + +SIR G+ + +VG +GSGKST+I L R Sbjct: 983 GDIELCHISFTYQTRPDVQVFRDLCLSIRAGQTVALVGESGSGKSTVISLLQR 1035 Score = 32.0 bits (71), Expect = 1.6 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G+I++ D+ Y RP + G ++ I G +VG +GSGKST+I + R Sbjct: 351 GEIELRDVCFSYPARPKEE-VFGGFSLLIPSGTTTALVGESGSGKSTVISLIER 403
>MDR4_ARATH (O80725) Multidrug resistance protein 4 (P-glycoprotein 4)| Length = 1286 Score = 39.7 bits (91), Expect = 0.008 Identities = 22/54 (40%), Positives = 35/54 (64%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI++ + +Y RP+ I + + +SIR G+ + +VG +GSGKST+I L R Sbjct: 1040 GDIELRHVSFKYPARPDVQ-IFQDLCLSIRAGKTVALVGESGSGKSTVIALLQR 1092 Score = 38.5 bits (88), Expect = 0.017 Identities = 20/54 (37%), Positives = 34/54 (62%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRY--RPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI++ D+ Y RP+ I +G ++ I G + +VG++GSGKST++ + R Sbjct: 382 GDIELKDVYFTYPARPDEQ-IFRGFSLFISSGTTVALVGQSGSGKSTVVSLIER 434
>ATM1_YEAST (P40416) Transporter ATM1, mitochondrial precursor| Length = 690 Score = 39.7 bits (91), Expect = 0.008 Identities = 34/138 (24%), Positives = 59/138 (42%) Frame = +2 Query: 224 IGTLVLSITAFLMISLPSNFIKKEFVGMSLSYGLSLNSLVYFAISISCMLENDMVAVERV 403 +G LVL +S+P NF+ + + S + + +L L + V ++ Sbjct: 372 VGDLVLINQLVFQLSVPLNFLGSVYRDLKQSL-IDMETLF--------KLRKNEVKIKNA 422 Query: 404 NQFSTLPSEAEWKKEDHLPSPNWPTNGDIDISDLKVRYRPNTPLILKGINVSIRGGEKIG 583 + LP + DI ++ Y P+ ILK + +I G K Sbjct: 423 ERPLMLPENVPY---------------DITFENVTFGYHPDRK-ILKNASFTIPAGWKTA 466 Query: 584 VVGRTGSGKSTLIQALFR 637 +VG +GSGKST+++ +FR Sbjct: 467 IVGSSGSGKSTILKLVFR 484
>MDR12_ARATH (Q9C7F2) Multidrug resistance protein 12 (P-glycoprotein 14)| Length = 1247 Score = 39.7 bits (91), Expect = 0.008 Identities = 21/54 (38%), Positives = 32/54 (59%), Gaps = 2/54 (3%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTP--LILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 GDI+ ++ Y P P I K +N+ + G+ + VVG +GSGKST+I + R Sbjct: 1004 GDIEFRNVSFAY-PTRPEIAIFKNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMR 1056 Score = 33.1 bits (74), Expect = 0.72 Identities = 15/52 (28%), Positives = 27/52 (51%) Frame = +2 Query: 482 GDIDISDLKVRYRPNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFR 637 G I+ + Y ++ + ++ +I G+ VG +GSGKST+I + R Sbjct: 371 GKIEFCGVSFAYPSRPNMVFENLSFTIHSGKTFAFVGPSGSGKSTIISMVQR 422
>GLNQ_BACST (P27675) Glutamine transport ATP-binding protein glnQ| Length = 242 Score = 39.7 bits (91), Expect = 0.008 Identities = 17/35 (48%), Positives = 27/35 (77%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQALFRL 640 +LK IN++I GE + ++G +GSGKSTL++ + RL Sbjct: 16 VLKDINLTIHQGEVVVIIGPSGSGKSTLVRCINRL 50
>YTMN_BACSU (O34900) Probable amino-acid ABC transporter ATP-binding protein| ytmN Length = 259 Score = 39.7 bits (91), Expect = 0.008 Identities = 15/32 (46%), Positives = 26/32 (81%) Frame = +2 Query: 536 ILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 +LKGIN+++R GE + ++G +GSGK+T ++ L Sbjct: 16 VLKGINLTVRKGEVVTIIGPSGSGKTTFLRCL 47
>LOLD_PSESM (Q884I3) Lipoprotein-releasing system ATP-binding protein lolD| Length = 227 Score = 39.7 bits (91), Expect = 0.008 Identities = 15/37 (40%), Positives = 26/37 (70%) Frame = +2 Query: 521 PNTPLILKGINVSIRGGEKIGVVGRTGSGKSTLIQAL 631 P + ++L G+ + + GE++ +VG +GSGKSTL+ L Sbjct: 20 PESVVVLSGLQLELHPGERVAIVGTSGSGKSTLLNLL 56 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 93,093,000 Number of Sequences: 219361 Number of extensions: 2052950 Number of successful extensions: 8620 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 8043 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8531 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6029593548 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
