ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags5k05 |
|---|---|
| Clone Library Name | barley_pub |
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 347 bits (891), Expect = 1e-95 Identities = 168/203 (82%), Positives = 184/203 (90%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQIMHHLSGHKNVVAIK YED VHIVMELCAGGELFDRI ++GHYSERKAAEL RII Sbjct: 128 IQIMHHLSGHKNVVAIKDVYEDGQAVHIVMELCAGGELFDRIQEKGHYSERKAAELIRII 187 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V +V CHSLGVMHRDLKPENFLL +KDDDLS+KAIDFGLSVFFKPGQ+FT++VGSPYYV Sbjct: 188 VSIVAMCHSLGVMHRDLKPENFLLLDKDDDLSIKAIDFGLSVFFKPGQVFTELVGSPYYV 247 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL K+YGPE+DVW+AGVILY+LLSGVPPFWAETQQGIFDAVLKG IDF S+PWP IS Sbjct: 248 APEVLHKRYGPESDVWSAGVILYVLLSGVPPFWAETQQGIFDAVLKGHIDFQSDPWPKIS 307 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 DSAKDLI +ML+ P+ERL AHE Sbjct: 308 DSAKDLIRKMLSHCPSERLKAHE 330
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 331 bits (848), Expect = 1e-90 Identities = 157/203 (77%), Positives = 179/203 (88%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQIMHHL+GH NV++IKGAYED + VH+VME CAGGELFDRIIQRGHY+ERKAAELTR I Sbjct: 199 IQIMHHLAGHPNVISIKGAYEDVVAVHLVMECCAGGELFDRIIQRGHYTERKAAELTRTI 258 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 VGVVEACHSLGVMHRDLKPENFL +K +D LK IDFGLS+FFKP +FTDVVGSPYYV Sbjct: 259 VGVVEACHSLGVMHRDLKPENFLFVSKHEDSLLKTIDFGLSMFFKPDDVFTDVVGSPYYV 318 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL K+YGPEADVW+AGVI+YILLSGVPPFWAET+QGIF+ VL G +DF S+PWP IS Sbjct: 319 APEVLRKRYGPEADVWSAGVIVYILLSGVPPFWAETEQGIFEQVLHGDLDFSSDPWPSIS 378 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 +SAKDL+ +ML P +RLTAH+ Sbjct: 379 ESAKDLVRKMLVRDPKKRLTAHQ 401
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 322 bits (824), Expect = 8e-88 Identities = 152/203 (74%), Positives = 175/203 (86%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQIMHHLSG KN+V IK YED+ VHIVMELCAGGELF +I +RGHYSERKAAEL +II Sbjct: 122 IQIMHHLSGQKNIVTIKDTYEDEQAVHIVMELCAGGELFSKIQKRGHYSERKAAELIKII 181 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 VG++E CHS GVMHRDLKPENFLL + DD+ S+KAIDFGLSVFF+PGQ+F +VVGSPYY+ Sbjct: 182 VGIIETCHSHGVMHRDLKPENFLLLDADDEFSVKAIDFGLSVFFRPGQVFREVVGSPYYI 241 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL K+YGPEAD+WTAGVILY+LL+GVPPFWA+TQ GI++ VL G IDF S WP IS Sbjct: 242 APEVLEKRYGPEADIWTAGVILYVLLTGVPPFWADTQSGIYEKVLDGRIDFKSNRWPRIS 301 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 DSAKDLI +ML P P+ERL AHE Sbjct: 302 DSAKDLIKKMLCPYPSERLKAHE 324
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 312 bits (799), Expect = 6e-85 Identities = 151/203 (74%), Positives = 168/203 (82%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQIMHHLS H NVV I+G YED VH+VMELC GGELFDRI+Q+GHYSER+AA L + I Sbjct: 83 IQIMHHLSEHANVVRIEGTYEDSTAVHLVMELCEGGELFDRIVQKGHYSERQAARLIKTI 142 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V VVEACHSLGVMHRDLKPENFL D+D LKA DFGLSVF+KPG+ F DVVGSPYYV Sbjct: 143 VEVVEACHSLGVMHRDLKPENFLFDTIDEDAKLKATDFGLSVFYKPGESFCDVVGSPYYV 202 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL K YGPE+DVW+AGVILYILLSGVPPFWAE++ GIF +L G +DF SEPWP IS Sbjct: 203 APEVLRKLYGPESDVWSAGVILYILLSGVPPFWAESEPGIFRQILLGKLDFHSEPWPSIS 262 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 DSAKDLI +ML+ P RLTAHE Sbjct: 263 DSAKDLIRKMLDQNPKTRLTAHE 285
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 292 bits (747), Expect = 7e-79 Identities = 136/201 (67%), Positives = 167/201 (83%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQIM HLSG +N+V +GAYED+ VH+VMELCAGGELFDRII +GHYSER AA + R + Sbjct: 134 IQIMQHLSGQQNIVEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGHYSERAAATICRAV 193 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V VV CH +GVMHRDLKPENFLLA K+++ LKA DFGLSVF + G+++ D+VGS YYV Sbjct: 194 VNVVNICHFMGVMHRDLKPENFLLATKEENAMLKATDFGLSVFIEEGKMYRDIVGSAYYV 253 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL + YG E DVW+AGVILYILLSGVPPFWAET++GIFDA+L+G IDF+S+PWP IS Sbjct: 254 APEVLRRNYGKEIDVWSAGVILYILLSGVPPFWAETEKGIFDAILQGEIDFESQPWPSIS 313 Query: 589 DSAKDLITRMLNPRPAERLTA 651 +SAKDL+ +ML P +R+T+ Sbjct: 314 ESAKDLVRKMLTQDPKKRITS 334
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 288 bits (736), Expect = 1e-77 Identities = 134/201 (66%), Positives = 164/201 (81%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQI+ HLSG N+V KG +ED+ VH+VMELCAGGELFDRII +GHYSER AA + R I Sbjct: 130 IQILQHLSGQPNIVEFKGVFEDRQSVHLVMELCAGGELFDRIIAQGHYSERAAATICRQI 189 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V VV CH +GVMHRDLKPENFLL++KD D LKA DFGLSVF + G+++ ++VGS YYV Sbjct: 190 VNVVHVCHFMGVMHRDLKPENFLLSSKDKDAMLKATDFGLSVFIEEGKVYRNIVGSAYYV 249 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL + YG E D+W+AGVILYILLSGVPPFWAE ++GIFDA+L+GVIDF+SEPWP +S Sbjct: 250 APEVLRRSYGKEIDIWSAGVILYILLSGVPPFWAENEKGIFDAILEGVIDFESEPWPSVS 309 Query: 589 DSAKDLITRMLNPRPAERLTA 651 +SAKDL+ +ML P R+T+ Sbjct: 310 NSAKDLVRKMLTQDPRRRITS 330
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 282 bits (721), Expect = 7e-76 Identities = 133/201 (66%), Positives = 162/201 (80%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQIM HLSG N+V +GAYED+ VH+VMELCAGGELFDRII +GHY+ER AA + R + Sbjct: 114 IQIMQHLSGQPNIVEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGHYTERAAATICRAV 173 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V VV CH +GVMHRDLKPENFLLA +++ LKA DFGLSVF + G+++ D+VGS YYV Sbjct: 174 VNVVNICHFMGVMHRDLKPENFLLATMEENAMLKATDFGLSVFIEEGKMYRDIVGSAYYV 233 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 APEVL + YG E DVW+AGVILYILLSGVPPFWAE ++GIFDA+L IDF+S+PWP IS Sbjct: 234 APEVLRRSYGKEIDVWSAGVILYILLSGVPPFWAEIEKGIFDAILHEEIDFESQPWPSIS 293 Query: 589 DSAKDLITRMLNPRPAERLTA 651 +SAKDL+ +ML P +RLT+ Sbjct: 294 ESAKDLVRKMLTRDPKKRLTS 314
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 226 bits (576), Expect = 5e-59 Identities = 112/202 (55%), Positives = 139/202 (68%), Gaps = 1/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 ++I+ L+GH N+V A+ED V++VMELC GGEL DRI+ RG Y+E A + Sbjct: 200 VKILRALTGHNNLVQFYDAFEDHTNVYVVMELCEGGELLDRILSRGGKYTEDDAKAVMIQ 259 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I+ VV CH GV+HRDLKPENFL +KD+D LKAIDFGLS + KP + D+VGS YY Sbjct: 260 ILNVVAFCHLQGVVHRDLKPENFLFKSKDEDSQLKAIDFGLSDYVKPDERLNDIVGSAYY 319 Query: 406 VAPEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 VAPEVL + Y EADVW+ GVI YILL G PFWA T+ GIF AVLK + FD PWP + Sbjct: 320 VAPEVLHRSYSTEADVWSIGVISYILLCGSRPFWARTESGIFRAVLKANLSFDEPPWPSV 379 Query: 586 SDSAKDLITRMLNPRPAERLTA 651 S AKD + R+LN P +R+TA Sbjct: 380 SSEAKDFVKRLLNKDPRKRMTA 401
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 184 bits (466), Expect = 3e-46 Identities = 92/203 (45%), Positives = 127/203 (62%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+IM L H N+V + YE+ Y++++MELC+G ELFD II+ G ++E+ AA + + I Sbjct: 117 IEIMKKLD-HPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQI 175 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + HSL ++HRDLKPENFL +++ D LK IDFGLS G+ T G+PYYV Sbjct: 176 FSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYV 235 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 AP+VL KY + D+W++GVI+Y LL G PPF+ +T + V KG F W IS Sbjct: 236 APQVLDGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSIS 295 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 AK+LIT++L P ER T E Sbjct: 296 SDAKNLITKLLTYNPNERCTIEE 318
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 184 bits (466), Expect = 3e-46 Identities = 92/203 (45%), Positives = 127/203 (62%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+IM L H N+V + YE+ Y++++MELC+G ELFD II+ G ++E+ AA + + I Sbjct: 117 IEIMKKLD-HPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQI 175 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + HSL ++HRDLKPENFL +++ D LK IDFGLS G+ T G+PYYV Sbjct: 176 FSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYV 235 Query: 409 APEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 AP+VL KY + D+W++GVI+Y LL G PPF+ +T + V KG F W IS Sbjct: 236 APQVLDGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSIS 295 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 AK+LIT++L P ER T E Sbjct: 296 SDAKNLITKLLTYNPNERCTIEE 318
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 181 bits (460), Expect = 1e-45 Identities = 89/204 (43%), Positives = 128/204 (62%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I ++H + H N+VA+ YE +++++M+L +GGELFDRI+++G Y+ER A+ L + Sbjct: 67 IAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQV 125 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ H LG++HRDLKPEN L + D+D + DFGLS PG + + G+P YV Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYV 185 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APEVL +K Y D W+ GVI YILL G PPF+ E +F+ +LK +FDS W I Sbjct: 186 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI 245 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 SDSAKD I ++ P +R T + Sbjct: 246 SDSAKDFIRHLMEKDPEKRFTCEQ 269
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 181 bits (460), Expect = 1e-45 Identities = 89/204 (43%), Positives = 128/204 (62%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I ++H + H N+VA+ YE +++++M+L +GGELFDRI+++G Y+ER A+ L + Sbjct: 67 IAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQV 125 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ H LG++HRDLKPEN L + D+D + DFGLS PG + + G+P YV Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYV 185 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APEVL +K Y D W+ GVI YILL G PPF+ E +F+ +LK +FDS W I Sbjct: 186 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI 245 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 SDSAKD I ++ P +R T + Sbjct: 246 SDSAKDFIRHLMEKDPEKRFTCEQ 269
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 181 bits (460), Expect = 1e-45 Identities = 89/204 (43%), Positives = 128/204 (62%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I ++H + H N+VA+ YE +++++M+L +GGELFDRI+++G Y+ER A+ L + Sbjct: 67 IAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQV 125 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ H LG++HRDLKPEN L + D+D + DFGLS PG + + G+P YV Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYV 185 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APEVL +K Y D W+ GVI YILL G PPF+ E +F+ +LK +FDS W I Sbjct: 186 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI 245 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 SDSAKD I ++ P +R T + Sbjct: 246 SDSAKDFIRHLMEKDPEKRFTCEQ 269
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 177 bits (449), Expect = 2e-44 Identities = 85/195 (43%), Positives = 125/195 (64%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+N+VA++ YE ++++VM+L +GGELFDRI+++G Y+E+ A+ L R ++ V H Sbjct: 78 HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHR 137 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK- 432 +G++HRDLKPEN L ++D++ + DFGLS G + + G+P YVAPEVL +K Sbjct: 138 MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKP 197 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y D W+ GVI YILL G PPF+ E +F+ +LK +FDS W ISDSAKD I Sbjct: 198 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 257 Query: 613 RMLNPRPAERLTAHE 657 ++ P +R T + Sbjct: 258 NLMEKDPNKRYTCEQ 272
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 177 bits (449), Expect = 2e-44 Identities = 85/195 (43%), Positives = 125/195 (64%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+N+VA++ YE ++++VM+L +GGELFDRI+++G Y+E+ A+ L R ++ V H Sbjct: 78 HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHR 137 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK- 432 +G++HRDLKPEN L ++D++ + DFGLS G + + G+P YVAPEVL +K Sbjct: 138 MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKP 197 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y D W+ GVI YILL G PPF+ E +F+ +LK +FDS W ISDSAKD I Sbjct: 198 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 257 Query: 613 RMLNPRPAERLTAHE 657 ++ P +R T + Sbjct: 258 NLMEKDPNKRYTCEQ 272
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 173 bits (439), Expect = 4e-43 Identities = 90/204 (44%), Positives = 127/204 (62%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I ++ +S H N+VA++ +E ++++ MEL GGELFDRI++RG Y+E+ A+ L + Sbjct: 62 IAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQV 120 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 +G V HSLG++HRDLKPEN L A +D + DFGLS + G + G+P YV Sbjct: 121 LGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYV 179 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APE+L +K YG DVW GVI YILL G PPF+ E+ +F +L+ +FDS W I Sbjct: 180 APELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDI 239 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+SAKD I +L P +R T + Sbjct: 240 SESAKDFIRHLLERDPQKRFTCQQ 263
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 173 bits (439), Expect = 4e-43 Identities = 90/204 (44%), Positives = 127/204 (62%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I ++ +S H N+VA++ +E ++++ MEL GGELFDRI++RG Y+E+ A+ L + Sbjct: 62 IAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQV 120 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 +G V HSLG++HRDLKPEN L A +D + DFGLS + G + G+P YV Sbjct: 121 LGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYV 179 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APE+L +K YG DVW GVI YILL G PPF+ E+ +F +L+ +FDS W I Sbjct: 180 APELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDI 239 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+SAKD I +L P +R T + Sbjct: 240 SESAKDFIRHLLERDPQKRFTCQQ 263
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 173 bits (439), Expect = 4e-43 Identities = 90/204 (44%), Positives = 127/204 (62%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I ++ +S H N+VA++ +E ++++ MEL GGELFDRI++RG Y+E+ A+ L + Sbjct: 62 IAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQV 120 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 +G V HSLG++HRDLKPEN L A +D + DFGLS + G + G+P YV Sbjct: 121 LGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYV 179 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APE+L +K YG DVW GVI YILL G PPF+ E+ +F +L+ +FDS W I Sbjct: 180 APELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDI 239 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+SAKD I +L P +R T + Sbjct: 240 SESAKDFIRHLLERDPQKRFTCQQ 263
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 169 bits (429), Expect = 5e-42 Identities = 85/196 (43%), Positives = 123/196 (62%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 70 HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPYYVAPEVLCKK 432 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K+ Sbjct: 130 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AK+LI Sbjct: 190 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TAHE Sbjct: 250 NQMLTINPAKRITAHE 265
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 169 bits (429), Expect = 5e-42 Identities = 85/196 (43%), Positives = 123/196 (62%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 70 HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPYYVAPEVLCKK 432 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K+ Sbjct: 130 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AK+LI Sbjct: 190 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TAHE Sbjct: 250 NQMLTINPAKRITAHE 265
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 169 bits (429), Expect = 5e-42 Identities = 85/196 (43%), Positives = 123/196 (62%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 70 HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPYYVAPEVLCKK 432 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K+ Sbjct: 130 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AK+LI Sbjct: 190 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TAHE Sbjct: 250 NQMLTINPAKRITAHE 265
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 169 bits (427), Expect = 9e-42 Identities = 87/194 (44%), Positives = 117/194 (60%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +ED+ Y ++V E GGELF++II R + E AA + + I+ + H Sbjct: 123 HPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHK 182 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRD+KPEN LL NK+ L++K +DFGLS FF D +G+ YY+APEVL KKY Sbjct: 183 HNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLKKKY 242 Query: 436 GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITR 615 + DVW+ GVI+YILL G PPF + Q I V KG FD W ISD AK+LI Sbjct: 243 NEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKL 302 Query: 616 MLNPRPAERLTAHE 657 ML +R TA E Sbjct: 303 MLTYDYNKRCTAEE 316
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 168 bits (426), Expect = 1e-41 Identities = 87/194 (44%), Positives = 117/194 (60%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +ED+ Y ++V E GGELF++II R + E AA + + I+ + H Sbjct: 124 HPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHK 183 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRD+KPEN LL NK L++K +DFGLS FF D +G+ YY+APEVL KKY Sbjct: 184 HNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKY 243 Query: 436 GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITR 615 + DVW+ GVILYILL G PPF + Q I V KG FD W IS+ AK+LI Sbjct: 244 NEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKL 303 Query: 616 MLNPRPAERLTAHE 657 ML +R+TA E Sbjct: 304 MLTYDYNKRITAKE 317
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 168 bits (426), Expect = 1e-41 Identities = 87/194 (44%), Positives = 117/194 (60%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +ED+ Y ++V E GGELF++II R + E AA + + I+ + H Sbjct: 124 HPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHK 183 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRD+KPEN LL NK L++K +DFGLS FF D +G+ YY+APEVL KKY Sbjct: 184 HNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKY 243 Query: 436 GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITR 615 + DVW+ GVILYILL G PPF + Q I V KG FD W IS+ AK+LI Sbjct: 244 NEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKL 303 Query: 616 MLNPRPAERLTAHE 657 ML +R+TA E Sbjct: 304 MLTYDYNKRITAKE 317
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 167 bits (423), Expect = 3e-41 Identities = 83/210 (39%), Positives = 125/210 (59%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ +SGH N++ +K YE + +V +L GELFD + ++ SE++ ++ R + Sbjct: 74 VDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRAL 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ A H L ++HRDLKPEN LL DDD+++K DFG S PG+ +V G+P Y+ Sbjct: 134 LEVICALHKLNIVHRDLKPENILL---DDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 409 APEVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 APE++ C YG E D+W+ GVI+Y LL+G PPFW Q + ++ G F S Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 250 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W SD+ KDL++R L +P +R TA E Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQKRYTAEE 280
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 167 bits (422), Expect = 3e-41 Identities = 83/195 (42%), Positives = 124/195 (63%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+N+V ++ YE + ++VM+L +GGELFDRI++RG Y+E+ A+ + + ++ V+ H Sbjct: 77 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 136 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK- 432 G++HRDLKPEN L +++ + DFGLS + G I + G+P YVAPEVL +K Sbjct: 137 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPEVLAQKP 195 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y D W+ GVI YILL G PPF+ ET+ +F+ + +G +F+S W IS+SAKD I Sbjct: 196 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 255 Query: 613 RMLNPRPAERLTAHE 657 +L P ER T + Sbjct: 256 HLLEKDPNERYTCEK 270
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 166 bits (421), Expect = 4e-41 Identities = 82/195 (42%), Positives = 124/195 (63%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+N+V ++ YE + ++VM+L +GGELFDRI++RG Y+E+ A+ + + ++ V+ H Sbjct: 77 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 136 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK- 432 G++HRDLKPEN L +++ + DFGLS + G + + G+P YVAPEVL +K Sbjct: 137 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-VMSTACGTPGYVAPEVLAQKP 195 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y D W+ GVI YILL G PPF+ ET+ +F+ + +G +F+S W IS+SAKD I Sbjct: 196 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 255 Query: 613 RMLNPRPAERLTAHE 657 +L P ER T + Sbjct: 256 HLLEKDPNERYTCEK 270
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 166 bits (421), Expect = 4e-41 Identities = 82/195 (42%), Positives = 124/195 (63%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+N+V ++ YE + ++VM+L +GGELFDRI++RG Y+E+ A+ + + ++ V+ H Sbjct: 77 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 136 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK- 432 G++HRDLKPEN L +++ + DFGLS + G + + G+P YVAPEVL +K Sbjct: 137 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-VMSTACGTPGYVAPEVLAQKP 195 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y D W+ GVI YILL G PPF+ ET+ +F+ + +G +F+S W IS+SAKD I Sbjct: 196 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 255 Query: 613 RMLNPRPAERLTAHE 657 +L P ER T + Sbjct: 256 HLLEKDPNERYTCEK 270
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 165 bits (418), Expect = 1e-40 Identities = 85/204 (41%), Positives = 123/204 (60%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I IM +L H NV+ + +ED+ ++++M+LC GGELFD+II++G + E A+ + + I Sbjct: 158 IDIMKNLD-HPNVIKLLETFEDEEQIYLIMDLCTGGELFDKIIKKGSFVEMYASFIMKQI 216 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKP-GQIFTDVVGSPYY 405 V+ H + HRD+KPENFL +K + +K IDFGL+ +F G+PYY Sbjct: 217 FSVLNYLHIRNICHRDIKPENFLFYDKSTESLIKIIDFGLAAYFNDIDYEMKTKAGTPYY 276 Query: 406 VAPEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 VAP+VL Y + D+W+AGV+ YI+L G PPF+ E+ I V KG +F + W I Sbjct: 277 VAPQVLTGCYDYKCDLWSAGVLFYIILCGYPPFYGESDHEILSMVKKGKYNFKGKEWNNI 336 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 SD AKDLI R L +R+ A E Sbjct: 337 SDEAKDLIKRCLTIDSGKRINASE 360
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 165 bits (417), Expect = 1e-40 Identities = 84/196 (42%), Positives = 120/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHL 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPYYVAPEVLCKK 432 G++HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AKDLI Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TA E Sbjct: 250 NKMLTINPAKRITASE 265
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 165 bits (417), Expect = 1e-40 Identities = 84/196 (42%), Positives = 120/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHL 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPYYVAPEVLCKK 432 G++HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AKDLI Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TA E Sbjct: 250 NKMLTINPAKRITASE 265
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 164 bits (415), Expect = 2e-40 Identities = 81/210 (38%), Positives = 124/210 (59%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ +SGH N++ +K YE + +V +L GELFD + ++ SE++ ++ R + Sbjct: 74 VDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRAL 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ H L ++HRDLKPEN LL DD++++K DFG S +PG+ +V G+P Y+ Sbjct: 134 LEVICTLHKLNIVHRDLKPENILL---DDNMNIKLTDFGFSCQLEPGERLREVCGTPSYL 190 Query: 409 APEVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 APE++ C YG E D+W+ GVI+Y LL+G PPFW Q + ++ G F S Sbjct: 191 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 250 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W SD+ KDL++R L +P R TA E Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEE 280
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 164 bits (414), Expect = 3e-40 Identities = 83/196 (42%), Positives = 121/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + +++ +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCK- 429 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AKDLI Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248 Query: 610 TRMLNPRPAERLTAHE 657 +ML P++R+TA E Sbjct: 249 NKMLTINPSKRITAAE 264
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 164 bits (414), Expect = 3e-40 Identities = 83/196 (42%), Positives = 121/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + +++ +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCK- 429 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AKDLI Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248 Query: 610 TRMLNPRPAERLTAHE 657 +ML P++R+TA E Sbjct: 249 NKMLTINPSKRITAAE 264
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 164 bits (414), Expect = 3e-40 Identities = 83/196 (42%), Positives = 121/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + +++ +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCK- 429 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AKDLI Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248 Query: 610 TRMLNPRPAERLTAHE 657 +ML P++R+TA E Sbjct: 249 NKMLTINPSKRITAAE 264
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 163 bits (413), Expect = 4e-40 Identities = 85/208 (40%), Positives = 125/208 (60%), Gaps = 3/208 (1%) Frame = +1 Query: 37 CDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAEL 216 C++ + ++ + H N++ + +E V++VMEL GGELFDRII RG ++ER A + Sbjct: 138 CESELCVLRRVR-HTNIIQLMEVFETAERVYMVMELATGGELFDRIITRGSFTERDATRV 196 Query: 217 TRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ--IFTDVV 390 ++++ V+ H+LG+ HRDLKPEN L + D + DFGL+ K G + Sbjct: 197 LQMVLDGVKYLHTLGITHRDLKPENLLYYHPGADSKIMITDFGLASTRKKGDECLMKTTC 256 Query: 391 GSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 G+P Y+APE+L +K Y D+W GVI YILLSG PF + + ++ +LKG F Sbjct: 257 GTPEYIAPEILVRKPYTNAVDMWALGVISYILLSGTMPFEDDNRMRLYRQILKGKYSFSG 316 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTA 651 EPWP +S+ AKD I R+L P ERL+A Sbjct: 317 EPWPSVSNLAKDFIDRVLTVDPNERLSA 344
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 163 bits (412), Expect = 5e-40 Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++A+K ++ +++VMEL GGELFD+I+++G YSE AA L + IV V H Sbjct: 64 HPNIIALKELFDTPEKLYLVMELVTGGELFDKIVEKGSYSEADAANLVKKIVSAVGYLHG 123 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 L ++HRDLKPEN LL +K++ L + DFGLS + G+P YVAPEVL Sbjct: 124 LNIVHRDLKPENLLLKSKENHLEVAIADFGLSKIIGQTLVMQTACGTPSYVAPEVLNATG 183 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y E D+W+ GVI YILL G PPF+ +T IF+ +++ +F E W IS AKD I Sbjct: 184 YDKEVDMWSIGVITYILLCGFPPFYGDTVPEIFEQIMEANYEFPEEYWGGISKEAKDFIG 243 Query: 613 RMLNPRPAERLTA 651 ++L ++RL A Sbjct: 244 KLLVVDVSKRLNA 256
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 163 bits (412), Expect = 5e-40 Identities = 94/207 (45%), Positives = 129/207 (62%), Gaps = 5/207 (2%) Frame = +1 Query: 52 QIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIV 231 +I+ ++S H NV+ + YED VH+V+ELC+GGELFDRI+ + YSE +A+ + IV Sbjct: 105 RIVENVSPHPNVIDLYDVYEDTNGVHLVLELCSGGELFDRIVAQDKYSETEASTVVHQIV 164 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV----GSP 399 +EA H ++HRDLKPEN L + D SLK +DFGLS + FTD V GS Sbjct: 165 AGLEAIHRANIIHRDLKPENCLFLDVGKDSSLKIMDFGLSSV----EEFTDPVVGLFGSI 220 Query: 400 YYVAPEVLCK-KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 YV+PE L + K ++D+W+ GVILYILLSG PPF A+ + +L G F + W Sbjct: 221 DYVSPEALSQGKITTKSDMWSLGVILYILLSGYPPFIAQNNRQKQQMILNGNFSFYEKTW 280 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 IS SAK+LI+ +L PA+R +A E Sbjct: 281 KGISQSAKNLISSLLTVDPAKRPSAQE 307
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 163 bits (412), Expect = 5e-40 Identities = 83/196 (42%), Positives = 120/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + +++ Y ++V +L GGELF+ I+ R YSE A+ + I+ V CH Sbjct: 70 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCKK 432 GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K+ Sbjct: 130 NGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKE 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G D+ S W ++ AK+LI Sbjct: 190 PYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML P +R+TA E Sbjct: 250 NQMLTVNPNKRITAAE 265
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 163 bits (412), Expect = 5e-40 Identities = 83/208 (39%), Positives = 125/208 (60%), Gaps = 3/208 (1%) Frame = +1 Query: 37 CDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAEL 216 C++ ++++ + H N++ + +E Q V++VMEL GGELFDRII +G ++ER A + Sbjct: 139 CESELRVLRRVR-HANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRV 197 Query: 217 TRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ--IFTDVV 390 ++++ V H+LG+ HRDLKPEN L + D + DFGL+ K G + Sbjct: 198 LQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTC 257 Query: 391 GSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 G+P Y+APEVL +K Y D+W GVI YILLSG PF + + ++ +L+G + Sbjct: 258 GTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSG 317 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTA 651 EPWP +S+ AKD I R+L P R+TA Sbjct: 318 EPWPSVSNLAKDFIDRLLTVDPGARMTA 345
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 162 bits (411), Expect = 6e-40 Identities = 80/210 (38%), Positives = 125/210 (59%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ +SGH N++ +K YE + +V +L GELFD + ++ +E++ ++ R + Sbjct: 74 VDILQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRAL 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + VV H L ++HRDLKPEN LL DD++++K DFG S +PG+ +V G+P Y+ Sbjct: 134 LEVVCTLHKLNIVHRDLKPENILL---DDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYL 190 Query: 409 APEVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 APE++ C YG E D+W+ GVI+Y LL+G PPFW Q + ++ G F S Sbjct: 191 APEIIQCSMDEGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGS 250 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W SD+ KDL++R L +P +R +A E Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQDRCSAEE 280
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 162 bits (411), Expect = 6e-40 Identities = 91/207 (43%), Positives = 129/207 (62%), Gaps = 5/207 (2%) Frame = +1 Query: 52 QIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIV 231 +I+ +S H NV+ + YED VH+V+ELC+GGELFDRI+ + YSE +AAE+ + I Sbjct: 93 RIVEDVSPHPNVIHLHDVYEDANGVHLVLELCSGGELFDRIVAQDRYSESEAAEVVQQIA 152 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV----GSP 399 + A H ++HRDLKPEN L N++ +LK +DFGLS + FTD + GS Sbjct: 153 SGLAALHKSTIIHRDLKPENCLFLNQEKRSTLKIMDFGLSSV----EDFTDPIVALFGSI 208 Query: 400 YYVAPEVLCKKYGPEA-DVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 YV+PE L ++ A D+W+ GVILYILLSG PPF A + + +L G F+ W Sbjct: 209 DYVSPEALSQRQVSSASDMWSLGVILYILLSGCPPFHAPSNREKQQRILAGDFSFEEHTW 268 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 I+ SAKDLI+ +L+ P +R TA++ Sbjct: 269 KTITSSAKDLISSLLSVDPYKRPTAND 295
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 162 bits (410), Expect = 8e-40 Identities = 79/210 (37%), Positives = 125/210 (59%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ +SGH N++ +K YE + +V +L GELFD + ++ +E++ ++ R + Sbjct: 74 VDILQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRAL 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ H L ++HRDLKPEN LL DD++++K DFG S +PG+ +V G+P Y+ Sbjct: 134 LEVICTLHKLNIVHRDLKPENILL---DDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYL 190 Query: 409 APEVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 APE++ C YG E D+W+ GVI+Y LL+G PPFW Q + ++ G F S Sbjct: 191 APEIIQCSMDDGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGS 250 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W SD+ KDL++R L +P +R +A E Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQDRCSAEE 280
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 161 bits (408), Expect = 1e-39 Identities = 83/208 (39%), Positives = 125/208 (60%), Gaps = 3/208 (1%) Frame = +1 Query: 37 CDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAEL 216 C++ ++++ + H N++ + +E Q V++VMEL GGELFDRII +G ++ER A + Sbjct: 139 CESELRVLRRVR-HANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRV 197 Query: 217 TRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ--IFTDVV 390 ++++ V H+LG+ HRDLKPEN L + D + DFGL+ K G + Sbjct: 198 LQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTC 257 Query: 391 GSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 G+P Y+APEVL +K Y D+W GVI YILLSG PF + + ++ +L+G + Sbjct: 258 GTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYLG 317 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTA 651 EPWP +S+ AKD I R+L P R+TA Sbjct: 318 EPWPSVSNLAKDFIDRLLTVDPGARMTA 345
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 160 bits (405), Expect = 3e-39 Identities = 85/204 (41%), Positives = 120/204 (58%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I IM +L H NVV + +ED +++VMELC GGELFD+I+++G + E A+ + + I Sbjct: 164 IDIMKNLD-HPNVVKLLETFEDSNQIYLVMELCTGGELFDKIVKKGCFVETFASFIMKQI 222 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQI-FTDVVGSPYY 405 V+ H + HRD+KPENFL + + +K IDFGL+ +F G+PYY Sbjct: 223 FSVLNYLHIRNICHRDIKPENFLFYDMTPESLIKIIDFGLASYFTHNNYEMKTKAGTPYY 282 Query: 406 VAPEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 VAP+VL Y + D+W++GV+ YILL G PPF+ E+ I V KG F + W I Sbjct: 283 VAPQVLTGSYNYKCDMWSSGVLFYILLCGYPPFFGESDHEILSMVKKGKYQFKGKEWNNI 342 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+ AKDLI R L +R+ A E Sbjct: 343 SEEAKDLIKRCLTMDADKRICASE 366
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 160 bits (404), Expect = 4e-39 Identities = 82/196 (41%), Positives = 120/196 (61%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + +++ +L GGELF+ I+ R +YSE A+ + I+ V CH Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCK- 429 +GV+HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQRWFGFAGTPGYLSPEVLRKD 188 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + DF S W ++ AKDLI Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKARAYDFPSPEWDTVTPEAKDLI 248 Query: 610 TRMLNPRPAERLTAHE 657 +ML P++R+TA E Sbjct: 249 NKMLTINPSKRITAAE 264
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 155 bits (392), Expect = 1e-37 Identities = 90/207 (43%), Positives = 126/207 (60%), Gaps = 5/207 (2%) Frame = +1 Query: 52 QIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIV 231 +I+ ++S H NV+ + YED VH+V+ELC+GGELFDRI+ + YSE +AA + I Sbjct: 97 RIVENVSPHPNVIDLYDVYEDTNGVHLVLELCSGGELFDRIVAQDKYSETEAATVVHQIA 156 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV----GSP 399 +EA H ++HRDLKPEN L + D LK +DFGLS + FTD V GS Sbjct: 157 SGLEAVHRANIVHRDLKPENCLFLDVRKDSPLKIMDFGLSSV----EEFTDPVVGLFGSI 212 Query: 400 YYVAPEVLCK-KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 YV+PE L + K ++D+W+ GVILYILLSG PPF A+ + ++ G F + W Sbjct: 213 DYVSPEALSQGKITTKSDMWSLGVILYILLSGYPPFIAQNNRQKQQMIMNGNFSFYEKTW 272 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 IS AK+LI+ +L P++R +A E Sbjct: 273 KGISQPAKNLISSLLTVDPSKRPSALE 299
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 155 bits (392), Expect = 1e-37 Identities = 84/197 (42%), Positives = 118/197 (59%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ +K +E + +V+EL GGELFDRI+++G+YSER AA+ + I+ V H Sbjct: 94 HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHE 153 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL--CK 429 G++HRDLKPEN L A D LK DFGLS + + V G+P Y APE+L C Sbjct: 154 NGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC- 212 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAET-QQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 YGPE D+W+ G+I YILL G PF+ E Q +F +L F S W +S +AKDL Sbjct: 213 AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 272 Query: 607 ITRMLNPRPAERLTAHE 657 + +++ P +RLT + Sbjct: 273 VKKLIVLDPKKRLTTFQ 289
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 155 bits (392), Expect = 1e-37 Identities = 84/197 (42%), Positives = 118/197 (59%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ +K +E + +V+EL GGELFDRI+++G+YSER AA+ + I+ V H Sbjct: 98 HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHE 157 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL--CK 429 G++HRDLKPEN L A D LK DFGLS + + V G+P Y APE+L C Sbjct: 158 NGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC- 216 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAET-QQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 YGPE D+W+ G+I YILL G PF+ E Q +F +L F S W +S +AKDL Sbjct: 217 AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 276 Query: 607 ITRMLNPRPAERLTAHE 657 + +++ P +RLT + Sbjct: 277 VRKLIVLDPKKRLTTFQ 293
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 155 bits (391), Expect = 1e-37 Identities = 80/196 (40%), Positives = 117/196 (59%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ I+ V H Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCKK 432 ++HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 130 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AK+LI Sbjct: 190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TA + Sbjct: 250 NQMLTINPAKRITADQ 265
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 155 bits (391), Expect = 1e-37 Identities = 80/196 (40%), Positives = 117/196 (59%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ I+ V H Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCKK 432 ++HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 130 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AK+LI Sbjct: 190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TA + Sbjct: 250 NQMLTINPAKRITADQ 265
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 155 bits (391), Expect = 1e-37 Identities = 82/195 (42%), Positives = 117/195 (60%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +ED Y ++V ++ +GGELFD II R + E AA + + ++ + H Sbjct: 126 HINIMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHK 185 Query: 256 LGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 V+HRDLKPEN LL K+ +D+ +K IDFGLS F+ + D +G+ YY+AP+VL Sbjct: 186 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT 245 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y + D+W+ GVILYILLSG PPF + I V G FD + ISD AKDLI Sbjct: 246 YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKAKDLIK 305 Query: 613 RMLNPRPAERLTAHE 657 +ML A R++A + Sbjct: 306 KMLMYTSAVRISARD 320
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 155 bits (391), Expect = 1e-37 Identities = 83/195 (42%), Positives = 116/195 (59%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +ED Y ++V ++ GGELFD II R + E AA + + I+ + H Sbjct: 126 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHK 185 Query: 256 LGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 V+HRDLKPEN LL K+ +D+ +K IDFGLS F+ + D +G+ YY+AP+VL Sbjct: 186 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT 245 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y + D+W+ GVILYILLSG PPF + I V G FD + ISD AKDLI Sbjct: 246 YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIK 305 Query: 613 RMLNPRPAERLTAHE 657 +ML A R++A + Sbjct: 306 KMLMYTSAVRISARD 320
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 155 bits (391), Expect = 1e-37 Identities = 82/195 (42%), Positives = 117/195 (60%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +ED Y ++V ++ +GGELFD II R + E AA + + ++ + H Sbjct: 126 HINIMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHK 185 Query: 256 LGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 V+HRDLKPEN LL K+ +D+ +K IDFGLS F+ + D +G+ YY+AP+VL Sbjct: 186 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT 245 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y + D+W+ GVILYILLSG PPF + I V G FD + ISD AKDLI Sbjct: 246 YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKAKDLIK 305 Query: 613 RMLNPRPAERLTAHE 657 +ML A R++A + Sbjct: 306 KMLMYTSAVRISARD 320
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 155 bits (391), Expect = 1e-37 Identities = 80/196 (40%), Positives = 117/196 (59%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ + ++V +L GGELF+ I+ R +YSE A+ I+ V H Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQ 129 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCKK 432 ++HRDLKPEN LLA+K ++K DFGL++ + Q + G+P Y++PEVL K Sbjct: 130 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 189 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 YG D+W GVILYILL G PPFW E Q ++ + G DF S W ++ AK+LI Sbjct: 190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249 Query: 610 TRMLNPRPAERLTAHE 657 +ML PA+R+TA + Sbjct: 250 NQMLTINPAKRITADQ 265
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 153 bits (387), Expect = 4e-37 Identities = 83/197 (42%), Positives = 117/197 (59%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ +K +E + +V+EL GGELFDRI+++G+YSER A + + I+ V H Sbjct: 94 HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAVAYLHE 153 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL--CK 429 G++HRDLKPEN L A D LK DFGLS + + V G+P Y APE+L C Sbjct: 154 NGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC- 212 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAET-QQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 YGPE D+W+ G+I YILL G PF+ E Q +F +L F S W +S +AKDL Sbjct: 213 AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 272 Query: 607 ITRMLNPRPAERLTAHE 657 + +++ P +RLT + Sbjct: 273 VKKLIVLDPKKRLTTFQ 289
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 150 bits (380), Expect = 2e-36 Identities = 76/208 (36%), Positives = 121/208 (58%), Gaps = 7/208 (3%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I+ ++GH +++ + +YE ++ +V +L GELFD + ++ SE++ + R ++ Sbjct: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V H+ ++HRDLKPEN LL DD++ ++ DFG S +PG+ ++ G+P Y+AP Sbjct: 140 AVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAP 196 Query: 415 EVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEP 573 E+L C YG E D+W GVIL+ LL+G PPFW Q + +++G F S Sbjct: 197 EILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPE 256 Query: 574 WPVISDSAKDLITRMLNPRPAERLTAHE 657 W S + KDLI+R+L P RLTA + Sbjct: 257 WDDRSSTVKDLISRLLQVDPEARLTAEQ 284
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 148 bits (374), Expect = 1e-35 Identities = 75/210 (35%), Positives = 121/210 (57%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ ++GH +++ + +YE ++ +V +L GELFD + ++ SE++ + R + Sbjct: 78 MHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSL 137 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V H ++HRDLKPEN LL DD++ ++ DFG S +PG+ ++ G+P Y+ Sbjct: 138 LEAVNFLHVNNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYL 194 Query: 409 APEVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 APE+L C YG E D+W GVIL+ LL+G PPFW Q + +++G F S Sbjct: 195 APEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSS 254 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W S++ KDLI ++L P RLTA + Sbjct: 255 PEWDDRSNTVKDLIAKLLQVDPNARLTAEQ 284
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 147 bits (372), Expect = 2e-35 Identities = 74/210 (35%), Positives = 122/210 (58%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ ++GH +++ + +YE ++ +V +L GELFD + ++ SE++ + R + Sbjct: 78 MHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSL 137 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V H+ ++HRDLKPEN LL DD++ ++ DFG S + G+ ++ G+P Y+ Sbjct: 138 LEAVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYL 194 Query: 409 APEVL-CKK------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 APE+L C YG E D+W GVIL+ LL+G PPFW Q + +++G F S Sbjct: 195 APEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTS 254 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W S++ KDLI+++L P RLTA + Sbjct: 255 PEWDDCSNTVKDLISKLLQVDPEARLTAEQ 284
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 146 bits (369), Expect = 5e-35 Identities = 83/196 (42%), Positives = 120/196 (61%), Gaps = 4/196 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + +++VMEL GG+LFD I Y+ER A+ + + ++ HS Sbjct: 445 HPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 504 Query: 256 LGVMHRDLKPENFLL-ANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 L ++HRD+KPEN L+ ++D SLK DFGL+ G ++T V G+P YVAPE++ + Sbjct: 505 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLYT-VCGTPTYVAPEIIAET 562 Query: 433 -YGPEADVWTAGVILYILLSGVPPF--WAETQQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 YG + D+W AGVI YILL G PPF + Q+ +FD +L G +DF S W +SDSAK+ Sbjct: 563 GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKE 622 Query: 604 LITRMLNPRPAERLTA 651 LIT ML +R +A Sbjct: 623 LITMMLLVDVDQRFSA 638
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 146 bits (369), Expect = 5e-35 Identities = 78/208 (37%), Positives = 123/208 (59%), Gaps = 3/208 (1%) Frame = +1 Query: 37 CDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAEL 216 C + + ++ +S H+ +V + +E + V++VMEL GGELFDR+I +G ++ER A + Sbjct: 105 CVSELSVLRRVS-HRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRI 163 Query: 217 TRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFT--DVV 390 +++ + H+L + HR+LKPEN L + ++ + DFGL+ K +T + Sbjct: 164 LQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLC 223 Query: 391 GSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDS 567 G+P Y+APEVL +K Y D+W GVI Y LLSG PF E+Q ++ +LKG ++ Sbjct: 224 GTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTG 283 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTA 651 EPWP IS AKD I ++L R++A Sbjct: 284 EPWPSISHLAKDFIDKLLILEAGHRMSA 311
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 146 bits (368), Expect = 6e-35 Identities = 77/194 (39%), Positives = 112/194 (57%), Gaps = 2/194 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H ++ + +E + V++VMEL GGELFDRII +G ++ER A + +++ V+ H Sbjct: 132 HSYIIQLIEVFETKDKVYMVMELATGGELFDRIIAKGSFTERDATRVLNMVLDGVKYLHG 191 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCKK 432 LG+ HRDLKPEN L + D + DFGLS K P G+P Y+APE++ +K Sbjct: 192 LGITHRDLKPENLLYYHPGHDSKIMITDFGLSSTRKGPENFMRTTCGTPEYIAPEIIARK 251 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 Y + D+W GVI YILLSG PF E + ++ +LK + E W +S AKD I Sbjct: 252 PYMCQVDMWAVGVITYILLSGTMPFDDENKTRLYRLILKAKYSYAGEHWKDVSAQAKDFI 311 Query: 610 TRMLNPRPAERLTA 651 ++L P +RL+A Sbjct: 312 DKLLVVSPGDRLSA 325
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 146 bits (368), Expect = 6e-35 Identities = 79/195 (40%), Positives = 111/195 (56%), Gaps = 3/195 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +E ++++ EL GGELFDRI +G + E AA L R V+ H Sbjct: 88 HPNILHLVDFFETVNNLYLITELATGGELFDRICAKGSFYEADAAALMRTTTSAVKYLHD 147 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIF--TDVVGSPYYVAPEVLCK 429 G++HRDLKPEN L +KD + L DFGLS F++ Q + G+P Y+APEV + Sbjct: 148 NGIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRR 207 Query: 430 K-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 YG D+W GVI Y LLSG PF +Q + +A+L F+ W IS++AKD Sbjct: 208 TGYGKPVDMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDF 267 Query: 607 ITRMLNPRPAERLTA 651 I + L P++RLTA Sbjct: 268 IKKCLENDPSKRLTA 282
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 145 bits (367), Expect = 8e-35 Identities = 86/207 (41%), Positives = 122/207 (58%), Gaps = 5/207 (2%) Frame = +1 Query: 52 QIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIV 231 +I+ ++S H NV+ + YED+ VH+V+ELC+GGELFDRI+++ YSE AA + R I Sbjct: 99 KIVENVSPHPNVIDLYDVYEDENGVHLVLELCSGGELFDRIVKQERYSEVGAAAVVRQIA 158 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV----GSP 399 + A H ++HRDLKPEN L + D LK +DFGLS + FTD V GS Sbjct: 159 QGLAALHRSNIVHRDLKPENCLFLDNTVDSPLKIMDFGLSSV----EEFTDPVVGLFGSI 214 Query: 400 YYVAPEVLCK-KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 YV+PE L + + ++D+W GVILYILLSG PPF A++ + ++ G F + W Sbjct: 215 DYVSPEALSQGQVTSKSDMWALGVILYILLSGYPPFIAQSNRQKQQMIMAGEFSFYEKTW 274 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 K LI+ +L P +R +A E Sbjct: 275 KGFLCQPKQLISSLLKVDPDKRPSAQE 301
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 145 bits (366), Expect = 1e-34 Identities = 82/196 (41%), Positives = 119/196 (60%), Gaps = 4/196 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + +++VMEL GG+LFD I Y+ER A+ + + ++ HS Sbjct: 138 HPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHS 197 Query: 256 LGVMHRDLKPENFLL-ANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 L ++HRD+KPEN L+ ++D SLK DFGL+ G ++T V G+P YVAPE++ + Sbjct: 198 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLYT-VCGTPTYVAPEIIAET 255 Query: 433 -YGPEADVWTAGVILYILLSGVPPF--WAETQQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 YG + D+W AGVI YILL G PPF + Q+ +FD +L G +DF S W +SDSAK+ Sbjct: 256 GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKE 315 Query: 604 LITRMLNPRPAERLTA 651 LI ML +R +A Sbjct: 316 LINMMLLVNVDQRFSA 331
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 145 bits (366), Expect = 1e-34 Identities = 83/198 (41%), Positives = 118/198 (59%), Gaps = 4/198 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + E + +VMEL GG+LFD I Y+ER + + + + HS Sbjct: 448 HPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHS 507 Query: 256 LGVMHRDLKPENFLLAN-KDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 L ++HRD+KPEN L+ D SLK DFGL+ + G ++T V G+P YVAPE++ + Sbjct: 508 LSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE-GPLYT-VCGTPTYVAPEIIAET 565 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAET--QQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 YG + DVW AGVI YILL G PPF +E Q+ +FD +L G ++F + W I+DSAK+ Sbjct: 566 GYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKE 625 Query: 604 LITRMLNPRPAERLTAHE 657 LI++ML R TA E Sbjct: 626 LISQMLQVNVEARCTAGE 643
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 145 bits (366), Expect = 1e-34 Identities = 82/196 (41%), Positives = 119/196 (60%), Gaps = 4/196 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + +++VMEL GG+LFD I Y+ER A+ + + ++ HS Sbjct: 461 HPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHS 520 Query: 256 LGVMHRDLKPENFLL-ANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 L ++HRD+KPEN L+ ++D SLK DFGL+ G ++T V G+P YVAPE++ + Sbjct: 521 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLYT-VCGTPTYVAPEIIAET 578 Query: 433 -YGPEADVWTAGVILYILLSGVPPF--WAETQQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 YG + D+W AGVI YILL G PPF + Q+ +FD +L G +DF S W +SDSAK+ Sbjct: 579 GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKE 638 Query: 604 LITRMLNPRPAERLTA 651 LI ML +R +A Sbjct: 639 LINMMLLVNVDQRFSA 654
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 144 bits (363), Expect = 2e-34 Identities = 80/200 (40%), Positives = 115/200 (57%), Gaps = 9/200 (4%) Frame = +1 Query: 73 GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACH 252 GH N+V + + DQL+ +VMEL GGELF+RI ++ H+SE +A+ + R +V V H Sbjct: 477 GHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH 536 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKP-GQIFTDVVGSPYYVAPEVLCK 429 +GV+HRDLKPEN L +++D+L +K IDFG + P Q + +Y APE+L + Sbjct: 537 DVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQ 596 Query: 430 K-YGPEADVWTAGVILYILLSGVPPFWAETQQ-------GIFDAVLKGVIDFDSEPWPVI 585 Y D+W+ GVILY +LSG PF + + I + KG F+ E W + Sbjct: 597 NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNV 656 Query: 586 SDSAKDLITRMLNPRPAERL 645 S AKDLI +L P +RL Sbjct: 657 SQEAKDLIQGLLTVDPNKRL 676 Score = 91.7 bits (226), Expect = 2e-18 Identities = 62/216 (28%), Positives = 110/216 (50%), Gaps = 6/216 (2%) Frame = +1 Query: 16 KGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYS 195 K +T+ Q++ H+ +V + A++ + +H++++ GGELF + QR ++ Sbjct: 91 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 150 Query: 196 ERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQI 375 E + IV +E H LG+++RD+K EN LL D + + DFGLS F + Sbjct: 151 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL---DSNGHVVLTDFGLSKEFVADET 207 Query: 376 --FTDVVGSPYYVAPEVL---CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAV 540 G+ Y+AP+++ + D W+ GV++Y LL+G PF + ++ + Sbjct: 208 ERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI 267 Query: 541 LKGVIDFDSEPWP-VISDSAKDLITRMLNPRPAERL 645 + ++ P+P +S AKDLI R+L P +RL Sbjct: 268 SRRILK-SEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 144 bits (362), Expect = 3e-34 Identities = 81/203 (39%), Positives = 117/203 (57%), Gaps = 12/203 (5%) Frame = +1 Query: 73 GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACH 252 GH N+V + + DQL+ +VMEL GGELF+RI ++ H+SE +A+ + R +V V H Sbjct: 477 GHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH 536 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSP----YYVAPEV 420 +GV+HRDLKPEN L +++D+L +K IDFG F +P + +P +Y APE+ Sbjct: 537 DVGVVHRDLKPENLLFTDENDNLEIKIIDFG---FARPKPPDNQPLKTPCFTLHYAAPEL 593 Query: 421 LCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQ-------GIFDAVLKGVIDFDSEPW 576 L + Y D+W+ GVILY +LSG PF + + I + KG F+ E W Sbjct: 594 LNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW 653 Query: 577 PVISDSAKDLITRMLNPRPAERL 645 +S AKDLI +L P +RL Sbjct: 654 KNVSQEAKDLIQGLLTVDPNKRL 676 Score = 89.0 bits (219), Expect = 1e-17 Identities = 61/216 (28%), Positives = 108/216 (50%), Gaps = 6/216 (2%) Frame = +1 Query: 16 KGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYS 195 K +T+ Q++ H +V + A++ + +H++++ GGELF + QR ++ Sbjct: 91 KAKTTEHTRTERQVLEHTRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 150 Query: 196 ERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQI 375 E + IV +E H LG+++RD+K EN LL D + + DFGLS F + Sbjct: 151 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL---DSNGHVMLTDFGLSKEFVADET 207 Query: 376 --FTDVVGSPYYVAPEVL---CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAV 540 G+ Y+AP+++ + D W+ GV++Y LL+G PF + ++ + Sbjct: 208 ERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI 267 Query: 541 LKGVIDFDSEPWP-VISDSAKDLITRMLNPRPAERL 645 + ++ P+P +S AKDLI +L P +RL Sbjct: 268 SRRILK-SEPPYPQEMSALAKDLIQHLLMKDPKKRL 302
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 142 bits (359), Expect = 7e-34 Identities = 80/196 (40%), Positives = 116/196 (59%), Gaps = 4/196 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + E + +VMEL GG+LFD I Y+ER + + + + H Sbjct: 449 HPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHG 508 Query: 256 LGVMHRDLKPENFLLAN-KDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 L ++HRD+KPEN L+ D SLK DFGL+ + G ++T V G+P YVAPE++ + Sbjct: 509 LSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE-GPLYT-VCGTPTYVAPEIIAET 566 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAET--QQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 YG + D+W AGVI YILL G PPF +E Q+ +FD +L G ++F + W I+DSAK+ Sbjct: 567 GYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKE 626 Query: 604 LITRMLNPRPAERLTA 651 LI++ML R TA Sbjct: 627 LISQMLQVNVEARCTA 642
>MAPK3_BOVIN (Q3SYZ2) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 142 bits (359), Expect = 7e-34 Identities = 88/212 (41%), Positives = 120/212 (56%), Gaps = 13/212 (6%) Frame = +1 Query: 52 QIMHH--LSGHKNVVAIKGAYEDQLY----VHIVMELCAGGELFDRIIQRGH--YSERKA 207 ++ HH SG ++V I YE+ + + I+ME GGELF RI +RG ++ER+A Sbjct: 86 EVDHHWQASGGPHIVRILDVYENMHHSKRCLLIIMECMEGGELFSRIQERGDQAFTEREA 145 Query: 208 AELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV 387 AE+ R I ++ HS + HRD+KPEN L +KD D LK DFG + + T Sbjct: 146 AEIMRDIGTAIQFLHSRNIAHRDVKPENLLYTSKDKDAVLKLTDFGFAKETTQNALQTPC 205 Query: 388 VGSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK----GV 552 +PYYVAPEVL +KY D+W+ GVI+YILL G PPF++ T Q I + + G Sbjct: 206 Y-TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 264 Query: 553 IDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 F S W +S+ AK LI +L P ERLT Sbjct: 265 YGFPSPEWSEVSEDAKQLIRLLLKTDPTERLT 296
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 142 bits (357), Expect = 1e-33 Identities = 78/193 (40%), Positives = 117/193 (60%), Gaps = 1/193 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 HK ++ + AYE + +V++V+E GGELF+ + G Y+E+ A + + ++ +EA HS Sbjct: 164 HKYIIKLISAYEQEGFVYLVLEYLKGGELFEYLNNNGPYTEQVAKKAMKRVLIALEALHS 223 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 GV+HRDLK EN +L N +D SLK IDFGL+ F + GSP YVAPE+L C Sbjct: 224 NGVVHRDLKMENLMLENPNDPSSLKIIDFGLASFLNSPSM-NMRCGSPGYVAPEILKCAS 282 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 YG + D+++ GVIL+ +L G PPF + IF ++ I F+++ W S+S K++I Sbjct: 283 YGTKVDIFSLGVILFNILCGYPPFRGNNVKEIFKKNMRCHISFNTKHWINKSESVKEIIL 342 Query: 613 RMLNPRPAERLTA 651 M P +R TA Sbjct: 343 WMCCKNPDDRCTA 355
>MAPK3_HUMAN (Q16644) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK) Length = 382 Score = 140 bits (352), Expect = 4e-33 Identities = 86/212 (40%), Positives = 120/212 (56%), Gaps = 13/212 (6%) Frame = +1 Query: 52 QIMHH--LSGHKNVVAIKGAYEDQLY----VHIVMELCAGGELFDRIIQRGH--YSERKA 207 ++ HH SG ++V I YE+ + + I+ME GGELF RI +RG ++ER+A Sbjct: 84 EVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREA 143 Query: 208 AELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV 387 AE+ R I ++ HS + HRD+KPEN L +K+ D LK DFG + + T Sbjct: 144 AEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPC 203 Query: 388 VGSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK----GV 552 +PYYVAPEVL +KY D+W+ GVI+YILL G PPF++ T Q I + + G Sbjct: 204 Y-TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 262 Query: 553 IDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 F + W +S+ AK LI +L P ERLT Sbjct: 263 YGFPNPEWSEVSEDAKQLIRLLLKTDPTERLT 294
>MAPK3_RAT (Q66H84) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 139 bits (351), Expect = 6e-33 Identities = 87/212 (41%), Positives = 119/212 (56%), Gaps = 13/212 (6%) Frame = +1 Query: 52 QIMHH--LSGHKNVVAIKGAYEDQLY----VHIVMELCAGGELFDRIIQRGH--YSERKA 207 ++ HH SG ++V I YE+ + + IVME GGELF RI +RG ++ER+A Sbjct: 86 EVDHHWQASGGPHIVRILDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTEREA 145 Query: 208 AELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV 387 AE+ R I ++ HS + HRD+KPEN L +K+ D LK DFG + + T Sbjct: 146 AEIMRDIGTAIQFLHSQNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPC 205 Query: 388 VGSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK----GV 552 +PYYVAPEVL +KY D+W+ GVI+YILL G PPF++ T Q I + + G Sbjct: 206 Y-TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 264 Query: 553 IDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 F W +S+ AK LI +L P ERLT Sbjct: 265 YGFPKPEWADVSEDAKQLIRLLLKTDPTERLT 296
>MAPK3_MOUSE (Q3UMW7) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 139 bits (351), Expect = 6e-33 Identities = 87/212 (41%), Positives = 120/212 (56%), Gaps = 13/212 (6%) Frame = +1 Query: 52 QIMHH--LSGHKNVVAIKGAYEDQLY----VHIVMELCAGGELFDRIIQRGH--YSERKA 207 ++ HH SG ++V I YE+ + + IVME GGELF RI +RG ++ER+A Sbjct: 86 EVDHHWQASGGPHIVRILDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTEREA 145 Query: 208 AELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV 387 AE+ R I ++ HS + HRD+KPEN L +K+ D LK DFG + + T Sbjct: 146 AEIMRDIGTAIQFLHSRNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPC 205 Query: 388 VGSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK----GV 552 +PYYVAPEVL +KY D+W+ GVI+YILL G PPF++ T Q I + + G Sbjct: 206 Y-TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 264 Query: 553 IDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 F + W +S+ AK LI +L P ERLT Sbjct: 265 YSFPNPEWLDVSEDAKQLIRLLLKTDPTERLT 296
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 139 bits (350), Expect = 7e-33 Identities = 77/200 (38%), Positives = 112/200 (56%), Gaps = 9/200 (4%) Frame = +1 Query: 73 GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACH 252 GH NVV + Y DQL+ +VMEL GGEL +RI ++ H+SE +A+ + R +V V H Sbjct: 467 GHPNVVKLHEVYHDQLHTFLVMELLKGGELLERIQKKQHFSETEASHIMRRLVSAVSHMH 526 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKP-GQIFTDVVGSPYYVAPEVLCK 429 +GV+HRDLKPEN L ++ D+ +K IDFG + P Q + +Y APE+ Sbjct: 527 DVGVVHRDLKPENLLFTDETDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELFNH 586 Query: 430 K-YGPEADVWTAGVILYILLSGVPPFWAETQQ-------GIFDAVLKGVIDFDSEPWPVI 585 Y D+W+ GVILY +LSG PF ++ + I + KG F+ E W + Sbjct: 587 NGYDESCDLWSLGVILYTMLSGQVPFQSQDKSLTCTSALEIMKKIKKGEFSFEGEAWKNV 646 Query: 586 SDSAKDLITRMLNPRPAERL 645 S+ AK+LI +L P +R+ Sbjct: 647 SEEAKELIQGLLTVDPNKRI 666 Score = 91.7 bits (226), Expect = 2e-18 Identities = 62/216 (28%), Positives = 109/216 (50%), Gaps = 6/216 (2%) Frame = +1 Query: 16 KGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYS 195 K +T+ Q++ H+ +V + A++ +H++++ GGELF + QR +S Sbjct: 81 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTDTKLHLILDYINGGELFTHLSQRERFS 140 Query: 196 ERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF--KPG 369 E + IV +E H LG+++RD+K EN LL D D + DFGLS F Sbjct: 141 ENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILL---DSDGHVVLTDFGLSKEFLTDEN 197 Query: 370 QIFTDVVGSPYYVAPEVL---CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAV 540 + G+ Y+AP+++ + D W+ GV++Y LL+G PF + ++ + Sbjct: 198 ERAYSFCGTIEYMAPDIVRGGDTGHDKAVDWWSVGVLMYELLTGASPFTVDGEKNSQAEI 257 Query: 541 LKGVIDFDSEPWP-VISDSAKDLITRMLNPRPAERL 645 + ++ P+P +S +KD+I R+L P +RL Sbjct: 258 SRRILK-SEPPYPQEMSALSKDIIQRLLMKDPKKRL 292
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 136 bits (342), Expect = 6e-32 Identities = 78/204 (38%), Positives = 119/204 (58%), Gaps = 2/204 (0%) Frame = +1 Query: 52 QIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIV 231 Q++HH NV+ + YE++ V +++EL +GGELFD + Q+ SE +A + I+ Sbjct: 80 QVLHH-----NVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 134 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDL-SLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V H+ + H DLKPEN +L +K+ + +K IDFGL+ + G F ++ G+P +V Sbjct: 135 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFV 194 Query: 409 APEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APE++ + G EAD+W+ GVI YILLSG PF +T+Q + DFD E + Sbjct: 195 APEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 254 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+ AKD I ++L +RLT E Sbjct: 255 SELAKDFIRKLLVKETRKRLTIQE 278
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 136 bits (342), Expect = 6e-32 Identities = 81/196 (41%), Positives = 109/196 (55%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + + + +V+E AG ELFD I+QRG E +A + I+ VE CH Sbjct: 109 HPHIIKLYDVIKSKDEIIMVIEF-AGKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHR 167 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRDLKPEN LL DD L++K DFGLS G GSP Y APEV+ K Sbjct: 168 HKIVHRDLKPENLLL---DDQLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 224 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW++GVILY++L G PF E +F + GV + +S AK L+ Sbjct: 225 YAGPEVDVWSSGVILYVMLCGRLPFDDEFIPALFKKISNGVYTLPN----YLSPGAKHLL 280 Query: 610 TRMLNPRPAERLTAHE 657 TRML P R+T HE Sbjct: 281 TRMLVVNPLNRITIHE 296
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1) (Ribosomal| protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 136 bits (342), Expect = 6e-32 Identities = 80/212 (37%), Positives = 124/212 (58%), Gaps = 9/212 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D YV++V EL GGEL D+I+++ +SER+A+ + I Sbjct: 477 IEILLRYGQHPNIITLKDVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTI 536 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE HS GV+HRDLKP N L ++ + S++ DFG F K + ++ +P Y Sbjct: 537 CKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFG---FAKQLRAENGLLMTPCY 593 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ GV+LY +L+G PF ++T + I + G Sbjct: 594 TANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSV 653 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 + W ISD AKDL+++ML+ P +RLTA + Sbjct: 654 NGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQ 685 Score = 82.0 bits (201), Expect = 1e-15 Identities = 54/192 (28%), Positives = 100/192 (52%), Gaps = 2/192 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 139 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 198 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 199 LGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 255 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S A+ L+ Sbjct: 256 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ----FLSAEAQSLL 311 Query: 610 TRMLNPRPAERL 645 + PA RL Sbjct: 312 RALFKRNPANRL 323
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 135 bits (340), Expect = 1e-31 Identities = 66/203 (32%), Positives = 122/203 (60%), Gaps = 9/203 (4%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H++++ ++ +E +++VMELC GEL + + ++GH+SE + + + + + H+ Sbjct: 172 HEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHN 231 Query: 256 LGVMHRDLKPENFLLA------NKDDDLSLKAIDFGLSVF--FKPGQIFTDVVGSPYYVA 411 ++HRDLK EN ++ N + +L++K DFGL+V + + G+P Y+A Sbjct: 232 NDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMA 291 Query: 412 PEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 PEV+ Y + D+W+ GV++Y+LL G PPF A +++ +F+ + KG + F++ W IS Sbjct: 292 PEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSIS 351 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 D AK ++ +++ PA R+TA E Sbjct: 352 DCAKSVLKQLMKVDPAHRITAKE 374
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 135 bits (339), Expect = 1e-31 Identities = 78/221 (35%), Positives = 125/221 (56%), Gaps = 2/221 (0%) Frame = +1 Query: 1 AQAHHKGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQ 180 ++A +G + + I+ + H N++ + YE++ V +++EL +GGELFD + Q Sbjct: 59 SRASRRGVCREEIEREVSILRQVL-HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQ 117 Query: 181 RGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDL-SLKAIDFGLSVF 357 + SE +A + I+ V H+ + H DLKPEN +L +K+ + +K IDFGL+ Sbjct: 118 KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE 177 Query: 358 FKPGQIFTDVVGSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFD 534 + G F ++ G+P +VAPE++ + G EAD+W+ GVI YILLSG PF +T+Q Sbjct: 178 IEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLA 237 Query: 535 AVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 + DFD E + S+ AKD I ++L +RLT E Sbjct: 238 NITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQE 278
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha| 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 134 bits (338), Expect = 2e-31 Identities = 74/207 (35%), Positives = 122/207 (58%), Gaps = 6/207 (2%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D +V++VMEL GGEL DRI+++ ++SER+A+++ I Sbjct: 457 IEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPY 402 ++ HS GV+HRDLKP N L ++ S++ DFG + + G + + Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN 576 Query: 403 YVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDFDSE 570 +VAPEVL ++ Y D+W+ G++LY +L+G PF +T + I + G Sbjct: 577 FVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGG 636 Query: 571 PWPVISDSAKDLITRMLNPRPAERLTA 651 W ISD+AKD++++ML+ P +RLTA Sbjct: 637 NWDSISDAAKDVVSKMLHVDPHQRLTA 663 Score = 82.0 bits (201), Expect = 1e-15 Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 2/194 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +V + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS 177 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 178 LGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 234 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S A+ L+ Sbjct: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQ----FLSGEAQSLL 290 Query: 610 TRMLNPRPAERLTA 651 + P RL A Sbjct: 291 RALFKRNPCNRLGA 304
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 134 bits (338), Expect = 2e-31 Identities = 72/196 (36%), Positives = 108/196 (55%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H ++V +E + +IV +L GGELFDRI + G ++E+ A++ R ++ V H Sbjct: 76 HPHIVHFVDWFESKDKFYIVTQLATGGELFDRICEYGKFTEKDASQTIRQVLDAVNYLHQ 135 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 ++HRDLKPEN L +D D L DFG++ + P ++ T + GS Y APEV+ K+ Sbjct: 136 RNIVHRDLKPENLLYLTRDLDSQLVLADFGIAKMLDNPAEVLTSMAGSFGYAAPEVMLKQ 195 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 +G D+W+ GVI Y LL G PF +E + + G + F W +S AKD I Sbjct: 196 GHGKAVDIWSLGVITYTLLCGYSPFRSENLTDLIEECRSGRVVFHERYWKDVSKDAKDFI 255 Query: 610 TRMLNPRPAERLTAHE 657 +L PA+R T+ E Sbjct: 256 LSLLQVDPAQRPTSEE 271
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 134 bits (338), Expect = 2e-31 Identities = 83/207 (40%), Positives = 115/207 (55%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + I+ LS H N+V+ K +E + +IV +L GGELFDRI+ RG ++E A E+ I Sbjct: 97 LSILQKLS-HPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQI 155 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ-IFTDVVGSPYY 405 +G VE HS V+HRDLKPEN L +K ++ L DFG++ K + + GS Y Sbjct: 156 LGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGY 215 Query: 406 VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFD--AVLKGVIDFDSEPW 576 VAPEVL + +G D+W+ GVI Y LL G PF AE+ +G + + + F W Sbjct: 216 VAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYW 275 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 IS K I + L PA+R TA E Sbjct: 276 DNISIDVKRFILKALRLNPADRPTATE 302
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 134 bits (337), Expect = 2e-31 Identities = 78/216 (36%), Positives = 119/216 (55%), Gaps = 5/216 (2%) Frame = +1 Query: 25 TSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERK 204 T+ + + I+I+ L+ H ++ IK ++ + Y +IV+EL GGELFDR++ E Sbjct: 270 TAPSVETEIEILKKLN-HPCIIKIKDVFDAEDY-YIVLELMEGGELFDRVVGNKRLKEAT 327 Query: 205 AAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTD 384 ++ V+ H G++HRDLKPEN LL+++++D +K DFG S + Sbjct: 328 CKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRT 387 Query: 385 VVGSPYYVAPEVLCKK----YGPEADVWTAGVILYILLSGVPPFWA-ETQQGIFDAVLKG 549 + G+P Y+APEVL Y D W+ GVIL+I LSG PPF +TQ + D + G Sbjct: 388 LCGTPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSG 447 Query: 550 VIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 +F E W +S+ A DL+ ++L P RLT E Sbjct: 448 KYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEE 483
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha| 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 134 bits (337), Expect = 2e-31 Identities = 79/210 (37%), Positives = 124/210 (59%), Gaps = 9/210 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D YV++VMEL GGEL DRI+++ +SER+A+++ I Sbjct: 457 IEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTI 516 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 ++ HS GV+HRDLKP N L ++ + S++ DFG F K + ++ +P Y Sbjct: 517 ARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFG---FAKQLRAENGLLMTPCY 573 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y DVW+ G++LY +L+G PF +T + I + G Sbjct: 574 TANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTA 651 W ISD+AKD++++ML+ P +RLTA Sbjct: 634 SGGNWDSISDAAKDVVSKMLHVDPQQRLTA 663 Score = 79.3 bits (194), Expect = 9e-15 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 2/194 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +V + A++ + ++++++ GG+LF R+ + ++E + ++ H Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHG 177 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 178 LGIIYRDLKPENILL---DEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRR 234 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S A+ L+ Sbjct: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQ----FLSAEAQSLL 290 Query: 610 TRMLNPRPAERLTA 651 + P RL A Sbjct: 291 RALFKRNPCNRLGA 304
>CSKP_RAT (Q62915) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 909 Score = 134 bits (336), Expect = 3e-31 Identities = 75/204 (36%), Positives = 120/204 (58%), Gaps = 6/204 (2%) Frame = +1 Query: 64 HLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH----YSERKAAELTRIIV 231 H+ H ++V + Y +++V E G +L I++R YSE A+ R I+ Sbjct: 67 HMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 126 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF-KPGQIFTDVVGSPYYV 408 + CH ++HRD+KP LLA+K++ +K FG+++ + G + VG+P+++ Sbjct: 127 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFM 186 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APEV+ ++ YG DVW GVIL+ILLSG PF+ T++ +F+ ++KG + W I Sbjct: 187 APEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHI 245 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+SAKDL+ RML PAER+T +E Sbjct: 246 SESAKDLVRRMLMLDPAERITVYE 269
>CSKP_HUMAN (O14936) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 134 bits (336), Expect = 3e-31 Identities = 75/204 (36%), Positives = 120/204 (58%), Gaps = 6/204 (2%) Frame = +1 Query: 64 HLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH----YSERKAAELTRIIV 231 H+ H ++V + Y +++V E G +L I++R YSE A+ R I+ Sbjct: 67 HMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 126 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF-KPGQIFTDVVGSPYYV 408 + CH ++HRD+KP LLA+K++ +K FG+++ + G + VG+P+++ Sbjct: 127 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFM 186 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APEV+ ++ YG DVW GVIL+ILLSG PF+ T++ +F+ ++KG + W I Sbjct: 187 APEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHI 245 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+SAKDL+ RML PAER+T +E Sbjct: 246 SESAKDLVRRMLMLDPAERITVYE 269
>CSKP_MOUSE (O70589) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 924 Score = 134 bits (336), Expect = 3e-31 Identities = 75/204 (36%), Positives = 120/204 (58%), Gaps = 6/204 (2%) Frame = +1 Query: 64 HLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH----YSERKAAELTRIIV 231 H+ H ++V + Y +++V E G +L I++R YSE A+ R I+ Sbjct: 67 HMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 126 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF-KPGQIFTDVVGSPYYV 408 + CH ++HRD+KP LLA+K++ +K FG+++ + G + VG+P+++ Sbjct: 127 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFM 186 Query: 409 APEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 APEV+ ++ YG DVW GVIL+ILLSG PF+ T++ +F+ ++KG + W I Sbjct: 187 APEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHI 245 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+SAKDL+ RML PAER+T +E Sbjct: 246 SESAKDLVRRMLMLDPAERITVYE 269
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 133 bits (335), Expect = 4e-31 Identities = 79/196 (40%), Positives = 105/196 (53%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + E +++VME GELFD I+++G E +A + I+ VE CH Sbjct: 99 HPHIIRLYEVIETPTDIYLVMEYVNSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHR 158 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++K DFGLS + G GSP Y APEV+ K Sbjct: 159 NMVVHRDLKPENLLL---DSKCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKL 215 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW+ GVILY LL G PF E +F + G+ S +S A+DLI Sbjct: 216 YAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSH----LSPGARDLI 271 Query: 610 TRMLNPRPAERLTAHE 657 RML P +R+T E Sbjct: 272 PRMLVVDPMKRVTIPE 287
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 132 bits (333), Expect = 7e-31 Identities = 82/197 (41%), Positives = 110/197 (55%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + + + +V+E AG ELFD I+QRG E +A + I+ VE CH Sbjct: 110 HPHIIKLYDVIKSKDEIIMVIEF-AGKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHR 168 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV-APEVLCKK 432 ++HRDLKPEN LL DD L++K DFGLS G GSP Y+ APEV+ K Sbjct: 169 HKIVHRDLKPENLLL---DDQLNVKIADFGLSNIMTDGNFLKTSCGSPNYMPAPEVISGK 225 Query: 433 Y--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 GPE DVW+AGVILY++L G PF E +F + GV + +S AK L Sbjct: 226 LYAGPEVDVWSAGVILYVMLCGRLPFDDEFIPALFKKISNGVYTLPN----YLSAGAKHL 281 Query: 607 ITRMLNPRPAERLTAHE 657 +TRML P R+T HE Sbjct: 282 LTRMLVVNPLNRITIHE 298
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha| 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 132 bits (333), Expect = 7e-31 Identities = 78/210 (37%), Positives = 122/210 (58%), Gaps = 9/210 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D YV++V EL GGEL D+I+++ +SER+A+ + I Sbjct: 464 IEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE H+ GV+HRDLKP N L ++ + S++ DFG F K + ++ +P Y Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFG---FAKQLRAENGLLMTPCY 580 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ GV+LY +L+G PF +T + I + G Sbjct: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTA 651 W +SD+AKDL+++ML+ P +RLTA Sbjct: 641 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTA 670 Score = 85.1 bits (209), Expect = 2e-16 Identities = 57/212 (26%), Positives = 107/212 (50%), Gaps = 2/212 (0%) Frame = +1 Query: 22 RTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSER 201 RT D +++ H +V + A++ + ++++++ GG+LF R+ + ++E Sbjct: 114 RTKMERDILVEVNHPF-----IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE 168 Query: 202 KAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIF 378 + ++ HSLG+++RDLKPEN LL D++ +K DFGLS + Sbjct: 169 DVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKESIDHEKKA 225 Query: 379 TDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVI 555 G+ Y+APEV+ ++ + AD W+ GV+++ +L+G PF + ++ +LK + Sbjct: 226 YSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKL 285 Query: 556 DFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 +S A+ L+ + PA RL A Sbjct: 286 GMPQ----FLSPEAQSLLRMLFKRNPANRLGA 313
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha| 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 132 bits (333), Expect = 7e-31 Identities = 78/210 (37%), Positives = 122/210 (58%), Gaps = 9/210 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D YV++V EL GGEL D+I+++ +SER+A+ + I Sbjct: 464 IEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE H+ GV+HRDLKP N L ++ + S++ DFG F K + ++ +P Y Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFG---FAKQLRAENGLLMTPCY 580 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ GV+LY +L+G PF +T + I + G Sbjct: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTA 651 W +SD+AKDL+++ML+ P +RLTA Sbjct: 641 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTA 670 Score = 85.1 bits (209), Expect = 2e-16 Identities = 57/212 (26%), Positives = 107/212 (50%), Gaps = 2/212 (0%) Frame = +1 Query: 22 RTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSER 201 RT D +++ H +V + A++ + ++++++ GG+LF R+ + ++E Sbjct: 114 RTKMERDILVEVNHPF-----IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE 168 Query: 202 KAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIF 378 + ++ HSLG+++RDLKPEN LL D++ +K DFGLS + Sbjct: 169 DVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKESIDHEKKA 225 Query: 379 TDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVI 555 G+ Y+APEV+ ++ + AD W+ GV+++ +L+G PF + ++ +LK + Sbjct: 226 YSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKL 285 Query: 556 DFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 +S A+ L+ + PA RL A Sbjct: 286 GMPQ----FLSPEAQSLLRMLFKRNPANRLGA 313
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 132 bits (333), Expect = 7e-31 Identities = 79/196 (40%), Positives = 104/196 (53%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ E +++VME GELFD I+++G E +A + I+ VE CH Sbjct: 77 HPHIIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHR 136 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++K DFGLS + G GSP Y APEV+ K Sbjct: 137 NMVVHRDLKPENLLL---DSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKL 193 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW+ GVILY LL G PF E +F + G+ S +S A+DLI Sbjct: 194 YAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSH----LSSEARDLI 249 Query: 610 TRMLNPRPAERLTAHE 657 RML P +R+T E Sbjct: 250 PRMLIVDPVKRITIPE 265
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 132 bits (333), Expect = 7e-31 Identities = 77/196 (39%), Positives = 115/196 (58%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H NV+ + YE++ V +++EL AGGELFD + ++ +E +A E + I+ V HS Sbjct: 73 HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILSGVYYLHS 132 Query: 256 LGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CK 429 L + H DLKPEN +L +++ +K IDFGL+ G F ++ G+P +VAPE++ + Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE 192 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 G EAD+W+ GVI YILLSG PF +T+Q V DF+ E + S AKD I Sbjct: 193 PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFI 252 Query: 610 TRMLNPRPAERLTAHE 657 R+L P +R+T + Sbjct: 253 RRLLVKDPKKRMTIQD 268
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 132 bits (333), Expect = 7e-31 Identities = 73/193 (37%), Positives = 115/193 (59%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +E++ V +++EL +GGELFD + ++ +E +A + + I+ V HS Sbjct: 73 HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 132 Query: 256 LGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CK 429 + H DLKPEN +L +K+ + +K IDFG++ + G F ++ G+P +VAPE++ + Sbjct: 133 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYE 192 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 G EAD+W+ GVI YILLSG PF ET+Q + DFD E + S+ AKD I Sbjct: 193 PLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFI 252 Query: 610 TRMLNPRPAERLT 648 R+L P R+T Sbjct: 253 RRLLVKDPKRRMT 265
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 132 bits (332), Expect = 9e-31 Identities = 77/198 (38%), Positives = 109/198 (55%), Gaps = 4/198 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+VA K +E + +I+ +L GGELFDRI+++G ++E A + I+ V+ HS Sbjct: 95 HPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHS 154 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPG-QIFTDVVGSPYYVAPEVLCKK 432 ++HRDLKPEN L +K D+ L DFG++ K ++ GS YVAPEVL + Sbjct: 155 QNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQD 214 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKG--VIDFDSEPWPVISDSAKD 603 +G D+W+ GVI Y LL G F AE Q D G + F W +S+ AK Sbjct: 215 GHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQ 274 Query: 604 LITRMLNPRPAERLTAHE 657 I + LN P++R TA E Sbjct: 275 FILKALNLDPSKRPTAAE 292
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 132 bits (331), Expect = 1e-30 Identities = 75/186 (40%), Positives = 106/186 (56%), Gaps = 9/186 (4%) Frame = +1 Query: 115 QLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENF 294 QL+ +VMEL GGELF+RI ++ H+SE +A+ + R +V V H +GV+HRDLKPEN Sbjct: 555 QLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENL 614 Query: 295 LLANKDDDLSLKAIDFGLSVFFKP-GQIFTDVVGSPYYVAPEVLCKK-YGPEADVWTAGV 468 L +++D+L +K IDFG + P Q + +Y APE+L Y D+W+ GV Sbjct: 615 LFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGV 674 Query: 469 ILYILLSGVPPFWAETQQ-------GIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNP 627 ILY +LSG PF + + I + KG F+ E W +S AKDLI +L Sbjct: 675 ILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTV 734 Query: 628 RPAERL 645 P +RL Sbjct: 735 DPNKRL 740 Score = 91.3 bits (225), Expect = 2e-18 Identities = 61/216 (28%), Positives = 110/216 (50%), Gaps = 6/216 (2%) Frame = +1 Query: 16 KGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYS 195 K +T+ Q++ H+ +V + A++ + +H++++ GGELF + QR ++ Sbjct: 90 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 149 Query: 196 ERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQI 375 E + IV +E H LG+++RD+K EN LL D + + DFGLS F + Sbjct: 150 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL---DSNGHVVLTDFGLSKEFVADET 206 Query: 376 --FTDVVGSPYYVAPEVL---CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAV 540 G+ Y+AP+++ + D W+ GV++Y LL+G PF + ++ + Sbjct: 207 ERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI 266 Query: 541 LKGVIDFDSEPWP-VISDSAKDLITRMLNPRPAERL 645 + ++ P+P +S AKDL+ R+L P +RL Sbjct: 267 SRRILK-SEPPYPQEMSTVAKDLLQRLLMKDPKKRL 301
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha| 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 132 bits (331), Expect = 1e-30 Identities = 77/212 (36%), Positives = 123/212 (58%), Gaps = 9/212 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D +V++V EL GGEL D+I+++ +SER+A+ + I Sbjct: 460 IEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTI 519 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLS-LKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE HS GV+HRDLKP N L ++ + L+ DFG F K + ++ +P Y Sbjct: 520 SKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG---FAKQLRAENGLLMTPCY 576 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ GV+LY +L+G PF ++T + I + G Sbjct: 577 TANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTL 636 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W +S++AKDL+++ML+ P +RLTA + Sbjct: 637 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQ 668 Score = 81.6 bits (200), Expect = 2e-15 Identities = 54/192 (28%), Positives = 100/192 (52%), Gaps = 2/192 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 181 LGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S A+ L+ Sbjct: 238 GHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ----FLSTEAQSLL 293 Query: 610 TRMLNPRPAERL 645 + PA RL Sbjct: 294 RALFKRNPANRL 305
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 132 bits (331), Expect = 1e-30 Identities = 78/220 (35%), Positives = 125/220 (56%), Gaps = 2/220 (0%) Frame = +1 Query: 4 QAHHKGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQR 183 ++ +G + + + I+ + H NV+ + YE++ V +++EL AGGELFD + ++ Sbjct: 50 KSSRRGVSREDIEREVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLAEK 108 Query: 184 GHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFF 360 +E +A E + I+ V HSL + H DLKPEN +L +++ +K IDFGL+ Sbjct: 109 ESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKI 168 Query: 361 KPGQIFTDVVGSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDA 537 G F ++ G+P +VAPE++ + G EAD+W+ GVI YILLSG PF +T+Q Sbjct: 169 DFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLAN 228 Query: 538 VLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 V +F+ E + S AKD I R+L P +R+T + Sbjct: 229 VSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQD 268
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 132 bits (331), Expect = 1e-30 Identities = 73/193 (37%), Positives = 113/193 (58%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +E++ V +++EL +GGELFD + ++ +E +A + + I+ V HS Sbjct: 73 HPNIITLHDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 132 Query: 256 LGVMHRDLKPENFLLANKDD-DLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CK 429 + H DLKPEN +L +K +K IDFG++ + G F ++ G+P +VAPE++ + Sbjct: 133 KRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYE 192 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 G EAD+W+ GVI YILLSG PF ET+Q + DFD E + S+ AKD I Sbjct: 193 PLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSSTSELAKDFI 252 Query: 610 TRMLNPRPAERLT 648 R+L P R+T Sbjct: 253 RRLLVKDPKRRMT 265
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 132 bits (331), Expect = 1e-30 Identities = 73/193 (37%), Positives = 113/193 (58%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + +E++ V +++EL +GGELFD + ++ +E +A + + I+ V HS Sbjct: 73 HPNIITLHDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 132 Query: 256 LGVMHRDLKPENFLLANKDD-DLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CK 429 + H DLKPEN +L +K +K IDFG++ + G F ++ G+P +VAPE++ + Sbjct: 133 KRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYE 192 Query: 430 KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 G EAD+W+ GVI YILLSG PF ET+Q + DFD E + S+ AKD I Sbjct: 193 PLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSSTSELAKDFI 252 Query: 610 TRMLNPRPAERLT 648 R+L P R+T Sbjct: 253 RRLLVKDPKRRMT 265
>MAPK2_DROME (P49071) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) Length = 359 Score = 132 bits (331), Expect = 1e-30 Identities = 78/210 (37%), Positives = 114/210 (54%), Gaps = 11/210 (5%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYE----DQLYVHIVMELCAGGELFDRIIQR--GHYSERKAA 210 + + +SG + +V I YE D+ + +VME GGELF RI + G ++ER+AA Sbjct: 61 VDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAA 120 Query: 211 ELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV 390 ++ I V+ HS + HRDLKPEN L + +LK DFG + Sbjct: 121 QIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPC 180 Query: 391 GSPYYVAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAE----TQQGIFDAVLKGVI 555 +PYYVAPEVL +KY D+W+ GV++YI++ G PPF++ G+ + + G Sbjct: 181 YTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQY 240 Query: 556 DFDSEPWPVISDSAKDLITRMLNPRPAERL 645 DF W +S +AKDLI MLN P++RL Sbjct: 241 DFPDPEWTNVSQAAKDLIKGMLNVDPSKRL 270
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1) (Ribosomal| protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 131 bits (330), Expect = 2e-30 Identities = 77/212 (36%), Positives = 122/212 (57%), Gaps = 9/212 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++A+K Y++ +++V EL GGEL DRI+++ +SER+A+ + + Sbjct: 458 IEILRRYGQHPNIIALKDVYKEGNSIYVVTELMRGGELLDRILRQKFFSEREASSVLFTV 517 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE HS GV+HRDLKP N L ++ D S++ DFG F K + ++ +P Y Sbjct: 518 CKTVENLHSQGVVHRDLKPSNILYVDESGDPESIRICDFG---FAKQLRADNGLLMTPCY 574 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPF---WAETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ G++LY +L+G PF +T + I + G Sbjct: 575 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGLGDTPEEILARIGSGKFTL 634 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W +S +AKDL++RML+ P +RLTA + Sbjct: 635 RGGNWNTVSAAAKDLVSRMLHVDPHKRLTAKQ 666 Score = 81.6 bits (200), Expect = 2e-15 Identities = 53/192 (27%), Positives = 100/192 (52%), Gaps = 2/192 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 121 HPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 181 LGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S+ A+ L+ Sbjct: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ----FLSNEAQSLL 293 Query: 610 TRMLNPRPAERL 645 + P RL Sbjct: 294 RALFKRNPTNRL 305
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha| 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 130 bits (328), Expect = 3e-30 Identities = 76/212 (35%), Positives = 123/212 (58%), Gaps = 9/212 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D +V++V EL GGEL D+I+++ +SER+A+ + I Sbjct: 449 IEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTI 508 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLS-LKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE HS GV+HRDLKP N L ++ + L+ DFG F K + ++ +P Y Sbjct: 509 SKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG---FAKQLRAENGLLMTPCY 565 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ G++LY +L+G PF ++T + I + G Sbjct: 566 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 625 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W +S++AKDL+++ML+ P +RLTA + Sbjct: 626 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQ 657 Score = 65.9 bits (159), Expect = 1e-10 Identities = 48/170 (28%), Positives = 88/170 (51%), Gaps = 13/170 (7%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 181 LGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237 Query: 433 -YGPEADVWTAGVI--------LYILLS---GVPPFWAETQQGIFDAVLK 546 + AD W+ GV+ + ++L G+P F + Q + A+ K Sbjct: 238 GHTHSADWWSYGVLMGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFK 287
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha| 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 130 bits (327), Expect = 3e-30 Identities = 76/212 (35%), Positives = 123/212 (58%), Gaps = 9/212 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K Y+D +V++V EL GGEL D+I+++ +SER+A+ + I Sbjct: 460 IEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTI 519 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLS-LKAIDFGLSVFFKPGQIFTDVVGSPYY 405 VE HS GV+HRDLKP N L ++ + L+ DFG F K + ++ +P Y Sbjct: 520 GKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG---FAKQLRAENGLLMTPCY 576 Query: 406 ----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDF 561 VAPEVL ++ Y D+W+ G++LY +L+G PF ++T + I + G Sbjct: 577 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 636 Query: 562 DSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W +S++AKDL+++ML+ P +RLTA + Sbjct: 637 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQ 668 Score = 82.4 bits (202), Expect = 1e-15 Identities = 54/192 (28%), Positives = 100/192 (52%), Gaps = 2/192 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 181 LGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S A+ L+ Sbjct: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ----FLSTEAQSLL 293 Query: 610 TRMLNPRPAERL 645 + PA RL Sbjct: 294 RALFKRNPANRL 305
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 130 bits (327), Expect = 3e-30 Identities = 76/201 (37%), Positives = 112/201 (55%), Gaps = 11/201 (5%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACH- 252 H NVV + + DQL+ ++V+EL GGEL + I ++ H+SE +A+++ R +V V H Sbjct: 463 HPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHE 522 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVF--FKPGQIFTDVVGSPYYVAPEVLC 426 GV+HRDLKPEN L A+ +K IDFG + PG + Y APE+L Sbjct: 523 EAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA 582 Query: 427 KK-YGPEADVWTAGVILYILLSGVPPFWAETQQG-------IFDAVLKGVIDFDSEPWPV 582 ++ Y D+W+ GVILY++LSG PF + QG I + +G D E W Sbjct: 583 QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQG 642 Query: 583 ISDSAKDLITRMLNPRPAERL 645 +S+ AK+L+ +L PA+RL Sbjct: 643 VSEEAKELVRGLLTVDPAKRL 663 Score = 93.6 bits (231), Expect = 5e-19 Identities = 60/193 (31%), Positives = 102/193 (52%), Gaps = 4/193 (2%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + A++ +H++++ +GGE+F + QR ++ E + IV +E H LG+ Sbjct: 98 LVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGI 157 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFF--KPGQIFTDVVGSPYYVAPEVLCKK-- 432 ++RDLK EN LL D + + DFGLS F + + G+ Y+APE++ K Sbjct: 158 IYRDLKLENVLL---DSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTG 214 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 +G D W+ G++L+ LL+G PF E ++ V + ++ P I A+DL+ Sbjct: 215 HGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQ 274 Query: 613 RMLNPRPAERLTA 651 R+L P +RL A Sbjct: 275 RLLCKDPKKRLGA 287
>MAPK5_MOUSE (O54992) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) Length = 473 Score = 130 bits (326), Expect = 4e-30 Identities = 77/239 (32%), Positives = 122/239 (51%), Gaps = 24/239 (10%) Frame = +1 Query: 4 QAHHKGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQR 183 +A ++ R C I+ + N V + + IVME+ GGELF RI Q Sbjct: 58 KARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH 117 Query: 184 GHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK 363 H++E++A+++T+ I ++ CH L + HRDLKPEN L + D +K DFG + Sbjct: 118 RHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK-VD 176 Query: 364 PGQIFTDVVGSPYYVAPEVLCKK-------------------YGPEADVWTAGVILYILL 486 G + T +PYYVAP+VL + Y D+W+ GVI+Y++L Sbjct: 177 QGDLMTPQF-TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVML 235 Query: 487 SGVPPFWAE-----TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 G PPF+++ + + ++ G +F E W IS+ AKD++ ++L +P ERLT Sbjct: 236 CGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT 294
>MAPK5_HUMAN (Q8IW41) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase) Length = 473 Score = 129 bits (324), Expect = 8e-30 Identities = 77/239 (32%), Positives = 121/239 (50%), Gaps = 24/239 (10%) Frame = +1 Query: 4 QAHHKGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQR 183 +A ++ R C I+ + N V + + IVME+ GGELF RI Q Sbjct: 58 KARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH 117 Query: 184 GHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK 363 H++E++A+++T+ I + CH L + HRDLKPEN L + D +K DFG + Sbjct: 118 RHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK-ID 176 Query: 364 PGQIFTDVVGSPYYVAPEVLCKK-------------------YGPEADVWTAGVILYILL 486 G + T +PYYVAP+VL + Y D+W+ GVI+Y++L Sbjct: 177 QGDLMTPQF-TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVML 235 Query: 487 SGVPPFWAE-----TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 G PPF+++ + + ++ G +F E W IS+ AKD++ ++L +P ERLT Sbjct: 236 CGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT 294
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 129 bits (323), Expect = 1e-29 Identities = 78/196 (39%), Positives = 107/196 (54%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + + + +V+E AG ELFD I+QR SE++A + I+ VE CH Sbjct: 96 HPHIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQRNKMSEQEARRFFQQIISAVEYCHR 154 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRDLKPEN LL D+ L++K DFGLS G GSP Y APEV+ K Sbjct: 155 HKIVHRDLKPENLLL---DEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 211 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW+ GVILY++L PF E+ +F + GV +S A DLI Sbjct: 212 YAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPK----FLSPGASDLI 267 Query: 610 TRMLNPRPAERLTAHE 657 RML P R++ HE Sbjct: 268 KRMLIVNPLNRISIHE 283
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 129 bits (323), Expect = 1e-29 Identities = 78/202 (38%), Positives = 113/202 (55%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +Q+M L+ H N++ + E + ++IV E GE+FD + GH SE +A + I Sbjct: 75 VQLMKLLN-HPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQI 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + VE CH+ ++HRDLK EN LL D ++ +K DFG F+KPG+ + VGSP Y Sbjct: 134 LSAVEYCHNHHIVHRDLKTENLLL---DSNMDIKLADFGFGNFYKPGEPLSTCVGSPPYA 190 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV K+Y GP+ DVW+ GV+LY+L+ G PF + VL+G Sbjct: 191 APEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPF----F 246 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S + LI RML PA+R+T Sbjct: 247 MSQDCETLIRRMLVVDPAKRIT 268
>MAPK2_HUMAN (P49137) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 400 Score = 128 bits (321), Expect = 2e-29 Identities = 78/204 (38%), Positives = 111/204 (54%), Gaps = 12/204 (5%) Frame = +1 Query: 82 NVVAIKGAYEDQLYVH-----IVMELCAGGELFDRIIQRGH--YSERKAAELTRIIVGVV 240 ++V I YE+ LY IVME GGELF RI RG ++ER+A+E+ + I + Sbjct: 116 HIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 Query: 241 EACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEV 420 + HS+ + HRD+KPEN L +K + LK DFG + T +PYYVAPEV Sbjct: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Query: 421 L-CKKYGPEADVWTAGVILYILLSGVPPFWAE----TQQGIFDAVLKGVIDFDSEPWPVI 585 L +KY D+W+ GVI+YILL G PPF++ G+ + G +F + W + Sbjct: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+ K LI +L P +R+T E Sbjct: 295 SEEVKMLIRNLLKTEPTQRMTITE 318
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 128 bits (321), Expect = 2e-29 Identities = 75/193 (38%), Positives = 107/193 (55%), Gaps = 3/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + ++IV+E GGELFDRI+ +G E ++ + + +V V CH Sbjct: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPG-QIFTDVVGSPYYVAPEVLCKK 432 GV HRDLKPEN LL D + +LK DFGLS + G ++ G+P YVAPEVL + Sbjct: 128 KGVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 Query: 433 --YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 G AD+W+ GVIL+++L+G PF G++ + +F PW S K L Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPW--FSAEVKFL 240 Query: 607 ITRMLNPRPAERL 645 I R+L+P P R+ Sbjct: 241 IHRILDPNPKTRI 253
>MAPK2_MOUSE (P49138) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 386 Score = 127 bits (320), Expect = 2e-29 Identities = 78/204 (38%), Positives = 111/204 (54%), Gaps = 12/204 (5%) Frame = +1 Query: 82 NVVAIKGAYEDQLYVH-----IVMELCAGGELFDRIIQRGH--YSERKAAELTRIIVGVV 240 ++V I YE+ LY IVME GGELF RI RG ++ER+A+E+ + I + Sbjct: 102 HIVHIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 160 Query: 241 EACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEV 420 + HS+ + HRD+KPEN L +K + LK DFG + T +PYYVAPEV Sbjct: 161 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 220 Query: 421 L-CKKYGPEADVWTAGVILYILLSGVPPFWAE----TQQGIFDAVLKGVIDFDSEPWPVI 585 L +KY D+W+ GVI+YILL G PPF++ G+ + G +F + W + Sbjct: 221 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 280 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+ K LI +L P +R+T E Sbjct: 281 SEEVKMLIRNLLKTEPTQRMTITE 304
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 127 bits (320), Expect = 2e-29 Identities = 75/211 (35%), Positives = 114/211 (54%), Gaps = 5/211 (2%) Frame = +1 Query: 40 DAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELT 219 + I+I+ L+ H ++ IK ++ + Y +IV+EL GGELFD+++ E Sbjct: 271 ETEIEILKKLN-HPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYF 328 Query: 220 RIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSP 399 ++ V+ H G++HRDLKPEN LL+++++D +K DFG S + + G+P Sbjct: 329 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 388 Query: 400 YYVAPEVLCK----KYGPEADVWTAGVILYILLSGVPPFWA-ETQQGIFDAVLKGVIDFD 564 Y+APEVL Y D W+ GVIL+I LSG PPF TQ + D + G +F Sbjct: 389 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI 448 Query: 565 SEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 E W +S+ A DL+ ++L P R T E Sbjct: 449 PEVWAEVSEKALDLVKKLLVVDPKARFTTEE 479
>MAPK2_CRILO (P49136) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (P45-54 HSP27 kinase) (Fragment) Length = 329 Score = 127 bits (320), Expect = 2e-29 Identities = 78/204 (38%), Positives = 111/204 (54%), Gaps = 12/204 (5%) Frame = +1 Query: 82 NVVAIKGAYEDQLYVH-----IVMELCAGGELFDRIIQRGH--YSERKAAELTRIIVGVV 240 ++V I YE+ LY IVME GGELF RI RG ++ER+A+E+ + I + Sbjct: 45 HIVDIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 103 Query: 241 EACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEV 420 + HS+ + HRD+KPEN L +K + LK DFG + T +PYYVAPEV Sbjct: 104 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 163 Query: 421 L-CKKYGPEADVWTAGVILYILLSGVPPFWAE----TQQGIFDAVLKGVIDFDSEPWPVI 585 L +KY D+W+ GVI+YILL G PPF++ G+ + G +F + W + Sbjct: 164 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 223 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 S+ K LI +L P +R+T E Sbjct: 224 SEEVKMLIRNLLKTEPTQRMTITE 247
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 125 bits (315), Expect = 8e-29 Identities = 70/203 (34%), Positives = 115/203 (56%), Gaps = 2/203 (0%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 ++ L H NV+A+ +E++ +++V+E GGELFD ++ +G ER+A + IV Sbjct: 166 VIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVE 225 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CHS + HRDLKPEN LL K + +K DFG++ P ++ GSP+Y +P Sbjct: 226 GVSYCHSFNICHRDLKPENLLLDKK--NRRIKIADFGMAALELPNKLLKTSCGSPHYASP 283 Query: 415 EVLCKK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 E++ + +G +DVW+ G++L+ LL+G PF + + + V G S +S Sbjct: 284 EIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSN----LS 339 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 A+DLI+++L P +R+T E Sbjct: 340 SEARDLISKILVIDPEKRITTQE 362
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha| 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 125 bits (315), Expect = 8e-29 Identities = 73/210 (34%), Positives = 118/210 (56%), Gaps = 7/210 (3%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K ++D YV++V +L GGEL DRI+++ +SER+A+++ +I Sbjct: 468 IEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVI 527 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDL-SLKAIDFGLSVFFK--PGQIFTDVVGSP 399 V+ H GV+HRDLKP N L ++ S++ DFG + + G + T + Sbjct: 528 SKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY-TA 586 Query: 400 YYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFW---AETQQGIFDAVLKGVIDFDS 567 +VAPEVL ++ Y D+W+ GV+ Y +L+G PF +T + I + G Sbjct: 587 NFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSG 646 Query: 568 EPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W ISD AKDL++ ML+ P +R TA + Sbjct: 647 GNWDNISDGAKDLLSHMLHMDPHQRYTAEQ 676 Score = 80.1 bits (196), Expect = 5e-15 Identities = 54/210 (25%), Positives = 104/210 (49%), Gaps = 2/210 (0%) Frame = +1 Query: 22 RTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSER 201 RT D +++ H +V + A++ + ++++++ GG++F R+ + ++E Sbjct: 119 RTKMERDILVEVNHPF-----IVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEE 173 Query: 202 KAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIF 378 + ++ H LG+++RDLKPEN LL D+ +K DFGLS + Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILL---DEIGHIKLTDFGLSKESVDQEKKA 230 Query: 379 TDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVI 555 G+ Y+APEV+ ++ + AD W+ GV+++ +L+G PF + + + +LK + Sbjct: 231 YSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKL 290 Query: 556 DFDSEPWPVISDSAKDLITRMLNPRPAERL 645 +S A+ L+ + PA RL Sbjct: 291 GMPQ----FLSAEAQSLLRMLFKRNPANRL 316
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 125 bits (314), Expect = 1e-28 Identities = 77/196 (39%), Positives = 106/196 (54%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + + + +V+E AG ELFD I+QR SE++A + I+ VE CH Sbjct: 112 HPHIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 170 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRDLKPEN LL D+ L++K DFGLS G GSP Y APEV+ K Sbjct: 171 HKIVHRDLKPENLLL---DEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 227 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW+ GVILY++L PF E+ +F + GV +S A LI Sbjct: 228 YAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPK----FLSPGAAGLI 283 Query: 610 TRMLNPRPAERLTAHE 657 RML P R++ HE Sbjct: 284 KRMLIVNPLNRISIHE 299
>MKNK1_XENTR (Q66JF3) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 417 Score = 125 bits (314), Expect = 1e-28 Identities = 76/230 (33%), Positives = 118/230 (51%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++ ++ G+KN++ + ED ++V E GG + I +R H++ER+A+++ + I Sbjct: 83 VETLYQCQGNKNILELIEFCEDDARFYLVFEKLRGGSILSHIQKRKHFNEREASKVVKDI 142 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV------ 390 ++ H+ G+ HRDLKPEN L KD +K DF L K T + Sbjct: 143 ASALDFLHTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNSACTPITTPELTT 202 Query: 391 --GSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------WAE-- 513 GS Y+APEV+ Y D+W+ GVILYI+LSG PPF W Sbjct: 203 PCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGADCGWDRGE 262 Query: 514 ----TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F+++ +G +F + W IS+SAKDLI+++L ERL+A Sbjct: 263 MCRVCQNKLFESIQEGKYEFPEKDWSHISNSAKDLISKLLVRDAKERLSA 312
>KCC1_METAN (O14408) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| Length = 382 Score = 125 bits (314), Expect = 1e-28 Identities = 74/207 (35%), Positives = 110/207 (53%), Gaps = 2/207 (0%) Frame = +1 Query: 43 AXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTR 222 A + ++ L+ H ++V +E + +IV +L GGELFDRI +G ++E A++ R Sbjct: 66 AELDMLQRLT-HPHIVKFVDWFESRDKFYIVTQLATGGELFDRICDQGKFTEVDASQTIR 124 Query: 223 IIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSP 399 I+ V+ H V+HRDLKPEN L +D D L DFG++ + T + GS Sbjct: 125 QIMTAVDYLHDNDVVHRDLKPENLLYVTRDPDSDLVLADFGITKTLDIKEETLTTMAGSF 184 Query: 400 YYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 Y APEV+ +K +G D+W+ GVI Y LL G PF +E + + + F W Sbjct: 185 GYAAPEVMEQKGHGKPVDMWSMGVITYTLLCGYSPFRSENLRDLLRECTAAPVPFHERYW 244 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S AKD I +L P P +R T+ E Sbjct: 245 KDVSQDAKDFILVLLVPEPEKRWTSKE 271
>MYLK_CHICK (P11799) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin] Length = 1906 Score = 125 bits (314), Expect = 1e-28 Identities = 78/201 (38%), Positives = 111/201 (55%), Gaps = 2/201 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I IM+ L H +V A+E++ + +V+E+ +GGELF+RII +ER+ + R Sbjct: 1499 ISIMNCLH-HPKLVQCVDAFEEKANIVMVLEMVSGGELFERIIDEDFELTERECIKYMRQ 1557 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I VE H G++H DLKPEN + NK S+K IDFGL+ + + G+P + Sbjct: 1558 ISEGVEYIHKQGIVHLDLKPENIMCVNKTGT-SIKLIDFGLARRLESAGSLKVLFGTPEF 1616 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 VAPEV+ + G E D+W+ GVI YIL+SG+ PF + V DFD E + Sbjct: 1617 VAPEVINYEPIGYETDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 1676 Query: 583 ISDSAKDLITRMLNPRPAERL 645 ISD AKD I+ +L RL Sbjct: 1677 ISDDAKDFISNLLKKDMKSRL 1697
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 125 bits (313), Expect = 1e-28 Identities = 74/196 (37%), Positives = 107/196 (54%), Gaps = 5/196 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H ++V + + +++VMEL GGELFDRI+ G +E ++ + ++ + CHS Sbjct: 77 HPHIVRLHEVLASKTKINMVMELVTGGELFDRIVSNGKLTETDGRKMFQQLIDGISYCHS 136 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVF---FKPGQIFTDVVGSPYYVAPEVLC 426 GV HRDLK EN LL K +K DFGLS F+ + GSP YVAPEVL Sbjct: 137 KGVFHRDLKLENVLLDAKG---HIKITDFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLA 193 Query: 427 KK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAK 600 + G +D+W+ GVILY++L+G PF ++ + KG D W +S A+ Sbjct: 194 NRGYDGAASDIWSCGVILYVILTGCLPFDDRNLAVLYQKICKG--DPPIPRW--LSPGAR 249 Query: 601 DLITRMLNPRPAERLT 648 +I RML+P P R+T Sbjct: 250 TMIKRMLDPNPVTRIT 265
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 125 bits (313), Expect = 1e-28 Identities = 76/202 (37%), Positives = 112/202 (55%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +Q+M L+ H N++ + E + ++IV E GE+FD + GH SE +A + I Sbjct: 75 VQLMKLLN-HPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQI 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + VE CH+ ++HRDLK EN LL D ++ +K DFG F+KPG+ + GSP Y Sbjct: 134 LSAVEYCHNHHIVHRDLKTENLLL---DGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYA 190 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV K+Y GP+ D+W+ GV+LY+L+ G PF + VL+G Sbjct: 191 APEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPF----F 246 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S + LI RML PA+R+T Sbjct: 247 MSQDCETLIRRMLVVDPAKRIT 268
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 124 bits (311), Expect = 2e-28 Identities = 74/201 (36%), Positives = 110/201 (54%), Gaps = 11/201 (5%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACH- 252 H NVV + DQL+ ++V+EL GGEL + I ++ +SE +A+++ R +V V H Sbjct: 463 HPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHE 522 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVF--FKPGQIFTDVVGSPYYVAPEVLC 426 GV+HRDLKPEN L A+ +K IDFG + P + + Y APE+L Sbjct: 523 EAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLA 582 Query: 427 KK-YGPEADVWTAGVILYILLSGVPPFWAETQQG-------IFDAVLKGVIDFDSEPWPV 582 ++ Y D+W+ GVILY++LSG PF + QG I + +G D E W Sbjct: 583 QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQG 642 Query: 583 ISDSAKDLITRMLNPRPAERL 645 +S+ AK+L+ +L PA+RL Sbjct: 643 VSEEAKELVRGLLTVDPAKRL 663 Score = 94.0 bits (232), Expect = 4e-19 Identities = 62/194 (31%), Positives = 106/194 (54%), Gaps = 5/194 (2%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + A++ +H++++ +GGE+F + QR ++ E + IV +E H LG+ Sbjct: 98 LVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGI 157 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFF--KPGQIFTDVVGSPYYVAPEVLCKK-- 432 ++RDLK EN LL D + + DFGLS F + + G+ Y+APE++ K Sbjct: 158 IYRDLKLENVLL---DSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAG 214 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV-ISDSAKDLI 609 +G D W+ G++L+ LL+G PF E ++ V + ++ S P+P+ I A+DL+ Sbjct: 215 HGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKC-SPPFPLRIGPVAQDLL 273 Query: 610 TRMLNPRPAERLTA 651 R+L P +RL A Sbjct: 274 QRLLCKDPKKRLGA 287
>MKNK1_XENLA (Q9YGW0) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 418 Score = 124 bits (311), Expect = 2e-28 Identities = 76/232 (32%), Positives = 118/232 (50%), Gaps = 29/232 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++ ++ G+KN++ + ED ++V E GG + I +R H++ER+A+++ + I Sbjct: 83 VETLYQCQGNKNILELIEFCEDDARFYLVFEKLLGGSILSHIQKRKHFNEREASKVVKDI 142 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV------ 390 ++ H+ G+ HRDLKPEN L KD +K DF L K T + Sbjct: 143 ASALDFLHTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNSACTTITTPELTT 202 Query: 391 --GSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------WAE-- 513 GS Y+APEV+ Y D+W+ GVILYI+LSG PPF W Sbjct: 203 PCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGTDCGWDRGE 262 Query: 514 ----TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 Q +F+++ +G +F + W IS SAKDLI+++L ERL+A + Sbjct: 263 VCRVCQNKLFESIQEGKYEFPEKDWSHISISAKDLISKLLVRDAKERLSAFQ 314
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 123 bits (309), Expect = 4e-28 Identities = 79/207 (38%), Positives = 115/207 (55%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + ++++ME +GGE+FD ++ G E++A R I Sbjct: 104 VRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 162 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLL---DADMNIKITDFGFSNEFTVGSKLDTFCGSPPYA 219 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G I F Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----- 274 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S ++L+ R L P +R T + Sbjct: 275 -YMSTDCENLLKRFLVLNPVKRGTLEQ 300
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 123 bits (309), Expect = 4e-28 Identities = 79/207 (38%), Positives = 115/207 (55%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + ++++ME +GGE+FD ++ G E++A R I Sbjct: 104 VRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 162 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGSKLDTFCGSPPYA 219 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G I F Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----- 274 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S ++L+ R L P +R T + Sbjct: 275 -YMSTDCENLLKRFLVLNPVKRGTLEQ 300
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 122 bits (307), Expect = 7e-28 Identities = 74/208 (35%), Positives = 112/208 (53%), Gaps = 5/208 (2%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I IM LS H N+V + + + ME GGELF++I + G SE + + + Sbjct: 71 ISIMRRLS-HPNIVKLHEVMATKSKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQL 129 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVF---FKPGQIFTDVVGSP 399 + V CH+ GV HRDLKPEN L+ D++ +LK DFGLS +P + + G+P Sbjct: 130 ISAVGYCHARGVYHRDLKPENLLI---DENGNLKVSDFGLSALTDQIRPDGLLHTLCGTP 186 Query: 400 YYVAPEVLCKK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEP 573 YVAPE+L KK G + DVW+ G++L++L++G PF ++ + KG F Sbjct: 187 AYVAPEILSKKGYEGAKVDVWSCGIVLFVLVAGYLPFNDPNVMNMYKKIYKGEYRFPR-- 244 Query: 574 WPVISDSAKDLITRMLNPRPAERLTAHE 657 W +S K ++R+L+ P R+T E Sbjct: 245 W--MSPDLKRFVSRLLDINPETRITIDE 270
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 122 bits (306), Expect = 9e-28 Identities = 79/213 (37%), Positives = 116/213 (54%), Gaps = 10/213 (4%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHY-SERKAAELTRI 225 + I+ S H+ VV + YED+ ++++ ELC GGEL D+++ + SE++ A + Sbjct: 496 VDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMAN 555 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKPGQIFTDVVGSPY 402 ++ V+ HS V HRDL N L A KD D SL+ +DFG F K + ++ +P Sbjct: 556 LLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFG---FAKQSRAENGMLMTPC 612 Query: 403 Y----VAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWA---ETQQGIFDAVLKGVID 558 Y VAPEVL K+ Y DVW+ GV+L+ +L+G PF +T I V G I Sbjct: 613 YTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKIS 672 Query: 559 FDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 W ISD AKDL+ +ML+ P R+TA + Sbjct: 673 MTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQ 705 Score = 84.0 bits (206), Expect = 4e-16 Identities = 57/201 (28%), Positives = 102/201 (50%), Gaps = 2/201 (0%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I+ H+S H +V + A++ + ++++++ GG+LF R+ + ++E + Sbjct: 157 ILAHIS-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTL 215 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFT-DVVGSPYYVA 411 +E HSLG+++RDLKPEN LL D D +K DFGLS + T G+ Y+A Sbjct: 216 ALEHLHSLGIVYRDLKPENILL---DADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMA 272 Query: 412 PEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 PEV+ ++ + AD W+ GV+++ +L+G PF + +LK + ++ Sbjct: 273 PEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPH----FLT 328 Query: 589 DSAKDLITRMLNPRPAERLTA 651 A+ L+ + RL A Sbjct: 329 QEAQSLLRALFKRNSQNRLGA 349
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 122 bits (306), Expect = 9e-28 Identities = 78/202 (38%), Positives = 114/202 (56%), Gaps = 4/202 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME +GGE+FD ++ G E++A R I Sbjct: 108 VRIMKILN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 167 VSAVQYCHQKYIVHRDLKAENLLL---DGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYA 223 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G I F Sbjct: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----- 278 Query: 577 PVISDSAKDLITRMLNPRPAER 642 +S ++L+ ++L P +R Sbjct: 279 -YMSTDCENLLKKLLVLNPIKR 299
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 122 bits (305), Expect = 1e-27 Identities = 79/207 (38%), Positives = 116/207 (56%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME +GGE+FD ++ G E++A R I Sbjct: 101 VRIMKVLN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G I F Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----- 271 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S ++L+ + L P++R T + Sbjct: 272 -YMSTDCENLLKKFLILNPSKRGTLEQ 297
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 122 bits (305), Expect = 1e-27 Identities = 79/207 (38%), Positives = 116/207 (56%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME +GGE+FD ++ G E++A R I Sbjct: 101 VRIMKVLN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G I F Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----- 271 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S ++L+ + L P++R T + Sbjct: 272 -YMSTDCENLLKKFLILNPSKRGTLEQ 297
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 121 bits (304), Expect = 2e-27 Identities = 70/217 (32%), Positives = 119/217 (54%), Gaps = 11/217 (5%) Frame = +1 Query: 40 DAXIQIMHHLS------GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRII--QRGHYS 195 D ++I+H ++ + V+ + YE + +V+E AGGE+FD+ + + + Sbjct: 100 DCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFK 159 Query: 196 ERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQI 375 E+ L R I+ V H+ V+H DLKP+N LL ++ +K +DFGLS K + Sbjct: 160 EKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEE 219 Query: 376 FTDVVGSPYYVAPEVLCKKYGP---EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK 546 +++G+P YVAPE+L Y P D+W+ GV+ Y++L+G+ PF +Q F + + Sbjct: 220 LREIMGTPEYVAPEIL--SYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQ 277 Query: 547 GVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 + + E + V+S+SA D I +L +P +R TA E Sbjct: 278 MNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEE 314
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 121 bits (304), Expect = 2e-27 Identities = 71/169 (42%), Positives = 100/169 (59%), Gaps = 2/169 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME +GGE+FD ++ G E++A R I Sbjct: 108 VRIMKILN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 167 VSAVQYCHQKCIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGNKLDTFCGSPPYA 223 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKG 549 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G Sbjct: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 272
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 121 bits (304), Expect = 2e-27 Identities = 71/169 (42%), Positives = 100/169 (59%), Gaps = 2/169 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME +GGE+FD ++ G E++A R I Sbjct: 108 VRIMKILN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 167 VSAVQYCHQKCIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGNKLDTFCGSPPYA 223 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKG 549 APE+ KKY GPE DVW+ GVILY L+SG PF + + + + VL+G Sbjct: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 272
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 121 bits (303), Expect = 2e-27 Identities = 76/202 (37%), Positives = 113/202 (55%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +QIM L+ H +++ + E + ++IV E GE+FD + GH SE +A + I Sbjct: 74 VQIMKLLN-HPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQI 132 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + VE CHS ++HRDLK EN LL D ++++K DFG F+K G+ + GSP Y Sbjct: 133 LSAVEYCHSHHIVHRDLKTENLLL---DANMNIKLADFGFGNFYKSGEPLSTWCGSPPYA 189 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV K+Y GP D+W+ GV+LY+L+ G PF + VL+G P+ Sbjct: 190 APEVFEGKEYEGPHLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRI---PY-F 245 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S+ + LI RML P +R+T Sbjct: 246 MSEDCETLIRRMLVVDPTKRIT 267
>MKNK1_BOVIN (Q58D94) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 420 Score = 121 bits (303), Expect = 2e-27 Identities = 72/242 (29%), Positives = 121/242 (50%), Gaps = 29/242 (11%) Frame = +1 Query: 13 HKGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHY 192 H G + + ++ ++ G+K+++ + +ED ++V E GG + I ++ H+ Sbjct: 71 HAGHSRSRVFREVETLYQCQGNKHILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHF 130 Query: 193 SERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQ 372 +ER+A+ + R + ++ H+ G+ HRDLKPEN L + + +K DF L K Sbjct: 131 NEREASRVVRDVAAALDFRHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNN 190 Query: 373 IFTDVV--------GSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF-- 504 T + GS Y+APEV+ Y D+W+ GV+LYI+LSG PPF Sbjct: 191 SCTPITTPELTTPCGSAEYMAPEVVEVFTDEATFYDKRCDLWSLGVVLYIMLSGYPPFVG 250 Query: 505 -------W------AETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERL 645 W Q +F+++ KG +F + W IS+ AKDLI+++L +RL Sbjct: 251 HCGADCGWDRGEVCTVCQNKLFESIQKGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRL 310 Query: 646 TA 651 +A Sbjct: 311 SA 312
>MYLK_HUMAN (Q15746) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1914 Score = 120 bits (302), Expect = 3e-27 Identities = 76/201 (37%), Positives = 109/201 (54%), Gaps = 2/201 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I IM+ L H +V A+E++ + +V+E+ +GGELF+RII +ER+ + R Sbjct: 1510 ISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQ 1568 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I VE H G++H DLKPEN + NK +K IDFGL+ + + G+P + Sbjct: 1569 ISEGVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEF 1627 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 VAPEV+ + G D+W+ GVI YIL+SG+ PF + V DFD E + Sbjct: 1628 VAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 1687 Query: 583 ISDSAKDLITRMLNPRPAERL 645 ISD AKD I+ +L RL Sbjct: 1688 ISDDAKDFISNLLKKDMKNRL 1708
>MYLK_MOUSE (Q6PDN3) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1941 Score = 120 bits (302), Expect = 3e-27 Identities = 76/201 (37%), Positives = 109/201 (54%), Gaps = 2/201 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I IM+ L H +V A+E++ + +V+E+ +GGELF+RII +ER+ + R Sbjct: 1532 ISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQ 1590 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I VE H G++H DLKPEN + NK +K IDFGL+ + + G+P + Sbjct: 1591 ISEGVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEF 1649 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 VAPEV+ + G D+W+ GVI YIL+SG+ PF + V DFD E + Sbjct: 1650 VAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 1709 Query: 583 ISDSAKDLITRMLNPRPAERL 645 ISD AKD I+ +L RL Sbjct: 1710 ISDDAKDFISNLLKKDMKNRL 1730
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 120 bits (300), Expect = 5e-27 Identities = 73/194 (37%), Positives = 104/194 (53%), Gaps = 5/194 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+ + E + ++VMELC GG L +I ++ E +A R ++ VE H Sbjct: 120 HPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHR 179 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS---VFFKPGQIFTDVVGSPYYVAPEVLC 426 GV+HRDLK EN LL D+D ++K IDFGLS F+ GSP Y APE+L Sbjct: 180 AGVVHRDLKIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236 Query: 427 -KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV-ISDSAK 600 KKYGP+ DVW+ GV +Y +L+G PF E A+ + ++D + P P +S A Sbjct: 237 RKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFS--LRALYQKMVDKEMNPLPTQLSTGAI 294 Query: 601 DLITRMLNPRPAER 642 + +L P P +R Sbjct: 295 SFLRSLLEPDPVKR 308
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 120 bits (300), Expect = 5e-27 Identities = 73/194 (37%), Positives = 104/194 (53%), Gaps = 5/194 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+ + E + ++VMELC GG L +I ++ E +A R ++ VE H Sbjct: 120 HPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHR 179 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS---VFFKPGQIFTDVVGSPYYVAPEVLC 426 GV+HRDLK EN LL D+D ++K IDFGLS F+ GSP Y APE+L Sbjct: 180 AGVVHRDLKIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236 Query: 427 -KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV-ISDSAK 600 KKYGP+ DVW+ GV +Y +L+G PF E A+ + ++D + P P +S A Sbjct: 237 RKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFS--LRALYQKMVDKEMNPLPTQLSTGAI 294 Query: 601 DLITRMLNPRPAER 642 + +L P P +R Sbjct: 295 SFLRSLLEPDPVKR 308
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 120 bits (300), Expect = 5e-27 Identities = 66/196 (33%), Positives = 111/196 (56%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +V+ + YE++ Y+++V+E +GGELFD ++++G + ++A + R IV ++ CHS Sbjct: 106 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 165 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 + HRDLKPEN LL D+ +++ DFG++ + GSP+Y PEV+ +K Sbjct: 166 YSICHRDLKPENLLL---DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEK 222 Query: 433 Y-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 Y G AD+W+ GVIL+ LL G PF + + + + V +GV I + L+ Sbjct: 223 YDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPH----FIPPDCQSLL 278 Query: 610 TRMLNPRPAERLTAHE 657 M+ P +RL+ + Sbjct: 279 RGMIEVEPEKRLSLEQ 294
>MYLK_RABIT (P29294) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1147 Score = 120 bits (300), Expect = 5e-27 Identities = 78/205 (38%), Positives = 110/205 (53%), Gaps = 4/205 (1%) Frame = +1 Query: 43 AXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELT 219 A I IM+ L H +V A+E++ + +V+E+ +GGELF+RII +ER+ + Sbjct: 740 AEIGIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYM 798 Query: 220 RIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSP 399 R I VE H G++H DLKPEN + NK +K IDFGL+ + + G+P Sbjct: 799 RQISEGVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTP 857 Query: 400 YYVAPEVLCKKYGP---EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSE 570 +VAPEV+ Y P D+W+ GVI YIL+SG+ PF + V DFD E Sbjct: 858 EFVAPEVI--NYEPISYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDE 915 Query: 571 PWPVISDSAKDLITRMLNPRPAERL 645 + ISD AKD I+ +L RL Sbjct: 916 AFDEISDDAKDFISNLLKKDMKNRL 940
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 120 bits (300), Expect = 5e-27 Identities = 76/196 (38%), Positives = 104/196 (53%), Gaps = 5/196 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H NVV + + + IV+E GGELF+ I G E +A + + ++ V+ CHS Sbjct: 77 HPNVVRLFEVMGSKARIFIVLEYVTGGELFEIIATNGRLKEEEARKYFQQLINAVDYCHS 136 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVF---FKPGQIFTDVVGSPYYVAPEVLC 426 GV HRDLK EN LL D +LK DFGLS K + G+P YVAPEV+ Sbjct: 137 RGVYHRDLKLENLLL---DASGNLKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIE 193 Query: 427 KK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAK 600 + G AD+W+ GVILY+LL+G PF + ++ + + F W S AK Sbjct: 194 DRGYDGAAADIWSCGVILYVLLAGFLPFEDDNIIALYKKISEA--QFTCPSW--FSTGAK 249 Query: 601 DLITRMLNPRPAERLT 648 LITR+L+P P R+T Sbjct: 250 KLITRILDPNPTTRIT 265
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 119 bits (299), Expect = 6e-27 Identities = 74/202 (36%), Positives = 109/202 (53%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +Q+M L+ H +++ + E + ++IV E GE+FD + GH SE +A + I Sbjct: 75 VQLMKLLN-HPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQI 133 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + VE CH ++HRDLK EN LL D ++ +K DFG F+K G+ + GSP Y Sbjct: 134 LSAVEYCHDHHIVHRDLKTENLLL---DGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYA 190 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV K+Y GP+ D+W+ GV+LY+L+ G PF + VL+G Sbjct: 191 APEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPF----F 246 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S + LI RML PA R+T Sbjct: 247 MSQDCESLIRRMLVVDPARRIT 268
>MYLK_BOVIN (Q28824) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1176 Score = 119 bits (299), Expect = 6e-27 Identities = 75/201 (37%), Positives = 109/201 (54%), Gaps = 2/201 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I IM+ L H +V A+E++ + +V+E+ +GGELF+RII +ER+ + + Sbjct: 771 ISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMKQ 829 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I VE H G++H DLKPEN + NK +K IDFGL+ + + G+P + Sbjct: 830 ISEGVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEF 888 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 VAPEV+ + G D+W+ GVI YIL+SG+ PF + V DFD E + Sbjct: 889 VAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 948 Query: 583 ISDSAKDLITRMLNPRPAERL 645 ISD AKD I+ +L RL Sbjct: 949 ISDDAKDFISNLLKKDMKNRL 969
>MYLK_SHEEP (O02827) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] (Fragment) Length = 438 Score = 119 bits (298), Expect = 8e-27 Identities = 75/201 (37%), Positives = 109/201 (54%), Gaps = 2/201 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I IM+ L H +V A+E++ + +V+E+ +GGELF+RII +ER+ + + Sbjct: 32 ISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMKQ 90 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I VE H G++H DLKPEN + NK +K IDFGL+ + + G+P + Sbjct: 91 ISEGVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEF 149 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 VAPEV+ + G D+W+ GVI YIL+SG+ PF + V DFD E + Sbjct: 150 VAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 209 Query: 583 ISDSAKDLITRMLNPRPAERL 645 ISD AKD I+ +L RL Sbjct: 210 ISDDAKDFISNLLKKDIKNRL 230
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 119 bits (298), Expect = 8e-27 Identities = 73/194 (37%), Positives = 104/194 (53%), Gaps = 5/194 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+ + E + ++VMELC GG L +I ++ E +A R ++ VE H Sbjct: 120 HPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHR 179 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS---VFFKPGQIFTDVVGSPYYVAPEVLC 426 GV+HRDLK EN LL D+D ++K IDFGLS F+ GSP Y APE+L Sbjct: 180 AGVVHRDLKIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236 Query: 427 -KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV-ISDSAK 600 KKYGP+ DVW+ GV +Y +L+G PF E A+ + ++D P P +S A Sbjct: 237 RKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFS--LRALYQKMVDKAMNPLPTQLSTGAV 294 Query: 601 DLITRMLNPRPAER 642 + + +L P P +R Sbjct: 295 NFLRSLLEPDPVKR 308
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 119 bits (298), Expect = 8e-27 Identities = 74/197 (37%), Positives = 101/197 (51%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + +VME C G+L D I+++ E +A + I+ VE CH Sbjct: 74 HPHIIRVYEVIVTPKDIFVVMEYCQNGDLLDYILEKRRLQEDEARRTFQQIISAVEYCHR 133 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++K DFGLS G GS Y APEV+ K Sbjct: 134 NKVVHRDLKPENLLL---DSKYNVKLADFGLSNVMHDGHFLKTSCGSLNYAAPEVISGKL 190 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV-ISDSAKDL 606 GPE DVW+ GVILY LL G PF + +F + G P+ +SD +DL Sbjct: 191 YAGPEIDVWSCGVILYALLCGAVPFDDDNIPNLFKKIKGGTYIL-----PIYLSDLVRDL 245 Query: 607 ITRMLNPRPAERLTAHE 657 I+RML P +R+T E Sbjct: 246 ISRMLIVDPMKRITIGE 262
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 119 bits (298), Expect = 8e-27 Identities = 76/207 (36%), Positives = 111/207 (53%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME + GE+FD ++ G E++A R I Sbjct: 107 VRIMKGLN-HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQI 165 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V CH ++HRDLK EN LL D + ++K DFG S F G GSP Y Sbjct: 166 VSAVHYCHQKNIVHRDLKAENLLL---DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYA 222 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE D+W+ GVILY L+SG PF + + + VL+G + F Sbjct: 223 APELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----- 277 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S + ++ R L PA+R T + Sbjct: 278 -YMSTDCESILRRFLVLNPAKRCTLEQ 303
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 119 bits (298), Expect = 8e-27 Identities = 76/207 (36%), Positives = 111/207 (53%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME + GE+FD ++ G E++A R I Sbjct: 107 VRIMKGLN-HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQI 165 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V CH ++HRDLK EN LL D + ++K DFG S F G GSP Y Sbjct: 166 VSAVHYCHQKNIVHRDLKAENLLL---DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYA 222 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ KKY GPE D+W+ GVILY L+SG PF + + + VL+G + F Sbjct: 223 APELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----- 277 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S + ++ R L PA+R T + Sbjct: 278 -YMSTDCESILRRFLVLNPAKRCTLEQ 303
>MKNK1_MOUSE (O08605) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 427 Score = 119 bits (298), Expect = 8e-27 Identities = 70/230 (30%), Positives = 117/230 (50%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++ ++ G++N++ + +ED ++V E GG + I +R H++ER+A+ + R + Sbjct: 95 VETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNEREASRVVRDV 154 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV------ 390 ++ H+ G+ HRDLKPEN L + + +K DF L K T + Sbjct: 155 ATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTT 214 Query: 391 --GSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------WAE-- 513 GS Y+APEV+ Y D+W+ GV+LYI+LSG PPF W Sbjct: 215 PCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGE 274 Query: 514 ----TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F+++ +G +F + W IS+ AKDLI+++L +RL+A Sbjct: 275 VCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSA 324
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 119 bits (297), Expect = 1e-26 Identities = 73/205 (35%), Positives = 112/205 (54%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I+ L H NV+ + +E +++V+E GELF+ +++RG E +A R I+ Sbjct: 83 IIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIII 142 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CH+LG++HRDLKPEN LL D ++K DFG++ G++ GSP+Y AP Sbjct: 143 GVSYCHALGIVHRDLKPENLLL---DHKYNIKIADFGMAALETEGKLLETSCGSPHYAAP 199 Query: 415 EVL--CKKYGPEADVWTAGVILYILLSGVPPFWAE--TQQGIFDAVLKGVIDFDSEPWPV 582 E++ G +DVW+ GVIL+ LL+G PF E + + V KG + S+ Sbjct: 200 EIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSD--DE 257 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS A+DLI ++L P R+ + Sbjct: 258 ISREAQDLIRKILTVDPERRIKTRD 282
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 119 bits (297), Expect = 1e-26 Identities = 73/205 (35%), Positives = 108/205 (52%), Gaps = 2/205 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+IM L+ H ++++I +E++ + I+ME + GEL+D I +R SER+ R I Sbjct: 105 IEIMSSLN-HPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 163 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V CH GV+HRDLK EN LL DD+ ++K DFGLS ++ + GSP Y Sbjct: 164 VSAVHYCHKNGVVHRDLKLENILL---DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYA 220 Query: 409 APEVLCKK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 +PE++ + GPE D W GV+LY L+ G PF + + + G ++P Sbjct: 221 SPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQP--- 277 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 A+ LI ML P R T + Sbjct: 278 --SDARGLIRWMLMVNPDRRATIED 300
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 119 bits (297), Expect = 1e-26 Identities = 68/217 (31%), Positives = 120/217 (55%), Gaps = 11/217 (5%) Frame = +1 Query: 40 DAXIQIMHHLS------GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRII--QRGHYS 195 D ++I+H ++ + V+ + YE + +V+E AGGE+ D+ + + ++ Sbjct: 83 DCRMEIIHEIAVLELAQDNPWVINLHEVYETSSEMILVLEYAAGGEISDQCVADRDEAFN 142 Query: 196 ERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQI 375 E+ L R I+ V H+ V+H DLKP+N LL ++ +K +DFGLS K + Sbjct: 143 EKDVQRLMRQILEGVHFLHTHDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRIVKNSEE 202 Query: 376 FTDVVGSPYYVAPEVLCKKYGP---EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK 546 +++G+P YVAPE+L Y P D+W+ GV+ Y++L+G+ PF + +Q F + + Sbjct: 203 LREIMGTPEYVAPEIL--SYDPISMATDMWSIGVLTYVMLTGISPFLGDNKQETFLNISQ 260 Query: 547 GVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 + + E + +S+SA D I ++L +P +R TA E Sbjct: 261 MNLSYSEEEFDTVSESAVDFIKKLLVKKPEDRATAEE 297
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 119 bits (297), Expect = 1e-26 Identities = 73/202 (36%), Positives = 113/202 (55%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +QIM L H +++ + E + +++V E GE+FD + G +E +A I Sbjct: 68 VQIMKMLD-HPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQI 126 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ CH ++HRDLK EN LL D+++++K DFG FFK G++ GSP Y Sbjct: 127 LSAVDYCHGRKIVHRDLKAENLLL---DNNMNIKIADFGFGNFFKSGELLATWCGSPPYA 183 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV ++Y GP+ D+W+ GV+LY+L+ G PF T + VL+G P+ Sbjct: 184 APEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRI---PY-F 239 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S+ + LI RML P++RLT Sbjct: 240 MSEDCEHLIRRMLVLDPSKRLT 261
>CDR1_SCHPO (P07334) Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein| kinase nim1) Length = 593 Score = 119 bits (297), Expect = 1e-26 Identities = 72/203 (35%), Positives = 107/203 (52%), Gaps = 2/203 (0%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 +M L H N++ + + D ++++ +E GELF I + G SER+AA I+ Sbjct: 55 LMMRLLRHPNILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILD 114 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CH HRDLK EN L+ K ++ +K DFG++ + GS +Y+AP Sbjct: 115 AVAHCHRFRFRHRDLKLENILI--KVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAP 172 Query: 415 EVLCKK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 E++ K G ADVW+ GVILY LLS PF + I++ + G D S IS Sbjct: 173 EIVSHKPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHGAYDLPSS----IS 228 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 +A+DL+ RML+ P+ R+T E Sbjct: 229 SAAQDLLHRMLDVNPSTRITIPE 251
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 118 bits (296), Expect = 1e-26 Identities = 73/205 (35%), Positives = 108/205 (52%), Gaps = 2/205 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+IM L+ H ++++I +E++ + I+ME + GEL+D I +R SER+ R I Sbjct: 104 IEIMSSLN-HPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 162 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V CH GV+HRDLK EN LL DD+ ++K DFGLS ++ + GSP Y Sbjct: 163 VSAVHYCHKNGVVHRDLKLENILL---DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYA 219 Query: 409 APEVLCKK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 +PE++ + GPE D W GV+LY L+ G PF + + + G ++P Sbjct: 220 SPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQP--- 276 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 A+ LI ML P R T + Sbjct: 277 --SDARGLIRWMLMVNPDRRATIED 299
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 117 bits (294), Expect = 2e-26 Identities = 73/202 (36%), Positives = 113/202 (55%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +QIM L H +++ + E + +++V E GE+FD + G +E +A I Sbjct: 68 VQIMKMLD-HPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQI 126 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ CH V+HRDLK EN LL D+++++K DFG FFK G++ GSP Y Sbjct: 127 LSAVDYCHGRKVVHRDLKAENLLL---DNNMNIKIADFGFGNFFKTGELLATWCGSPPYA 183 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV ++Y GP+ D+W+ GV+LY+L+ G PF T + VL+G P+ Sbjct: 184 APEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRI---PY-F 239 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S+ + LI RML P++RL+ Sbjct: 240 MSEDCEHLIRRMLVLDPSKRLS 261
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 117 bits (294), Expect = 2e-26 Identities = 72/196 (36%), Positives = 104/196 (53%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + +V+E AGGELFD I+++ +E + + I+ +E CH Sbjct: 91 HPHIIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHR 149 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 ++HRDLKPEN LL DD+L++K DFGLS G GSP Y APEV+ K Sbjct: 150 HKIVHRDLKPENLLL---DDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKL 206 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW+ G++LY++L G PF E +F V V +S A+ LI Sbjct: 207 YAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPD----FLSPGAQSLI 262 Query: 610 TRMLNPRPAERLTAHE 657 RM+ P +R+T E Sbjct: 263 RRMIVADPMQRITIQE 278
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 117 bits (294), Expect = 2e-26 Identities = 67/193 (34%), Positives = 109/193 (56%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +V+ + YE++ Y+++V+E +GGELFD ++++G + ++A + R I+ ++ CHS Sbjct: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 + HRDLKPEN LL D+ +++ DFG++ + GSP+Y PEV+ +K Sbjct: 135 HSICHRDLKPENLLL---DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEK 191 Query: 433 Y-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 Y G +ADVW+ GVIL+ LL G PF + + + + V +GV I + L+ Sbjct: 192 YDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPH----FIPPDCQSLL 247 Query: 610 TRMLNPRPAERLT 648 M A RLT Sbjct: 248 RGMSEVDAARRLT 260
>SAPK9_ORYSA (Q75V57) Serine/threonine-protein kinase SAPK9 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 9) Length = 361 Score = 117 bits (293), Expect = 3e-26 Identities = 77/205 (37%), Positives = 103/205 (50%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME +GGELF+RI G +SE +A + ++ Sbjct: 68 INHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICSAGRFSEDEARFFFQQLIS 127 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CHS+ V HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 128 GVSYCHSMQVCHRDLKLENTLLDGSTAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL KK G ADVW+ GV LY++L G PF F ++ + + + + Sbjct: 187 EVLLKKEYDGKIADVWSCGVTLYVMLVGAYPFEDPEDPKNFRKTIQKILGVQYSIPDYVH 246 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS +DLITR+ PA R+T E Sbjct: 247 ISPECRDLITRIFVGNPASRITMPE 271
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 117 bits (293), Expect = 3e-26 Identities = 77/207 (37%), Positives = 114/207 (55%), Gaps = 4/207 (1%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++IM L+ H N+V + E + +++VME +GGE+FD ++ G E++A R I Sbjct: 101 VRIMKVLN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V+ CH ++HRDLK EN LL D D+++K DFG S F G GSP Y Sbjct: 160 VLHVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216 Query: 409 APEVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APE+ K GPE DVW+ GVILY L+SG PF + + + + VL+G I F Sbjct: 217 APELFQGKKIDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----- 271 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S ++L+ + L P++R T + Sbjct: 272 -YMSTDCENLLKKFLILNPSKRGTLEQ 297
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 117 bits (292), Expect = 4e-26 Identities = 72/193 (37%), Positives = 97/193 (50%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + +VME +GGELFD I + G E +A L + I+ V+ CH Sbjct: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 133 HMVVHRDLKPENVLL---DAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W+ GVILY LL G PF E +F + GV ++ S L+ Sbjct: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVATLL 245 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 246 MHMLQVDPLKRAT 258
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 116 bits (291), Expect = 5e-26 Identities = 72/193 (37%), Positives = 97/193 (50%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + +VME +GGELFD I + G E +A L + I+ V+ CH Sbjct: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 133 HMVVHRDLKPENVLL---DAHMNAKIADFGLSNIMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W+ GVILY LL G PF E +F + GV ++ S L+ Sbjct: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVATLL 245 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 246 MHMLQVDPLKRAT 258
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 116 bits (291), Expect = 5e-26 Identities = 72/193 (37%), Positives = 97/193 (50%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + +VME +GGELFD I + G E +A L + I+ V+ CH Sbjct: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 133 HMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W+ GVILY LL G PF E +F + GV ++ S L+ Sbjct: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVATLL 245 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 246 MHMLQVDPLKRAT 258
>MYLK2_RABIT (P07313) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 607 Score = 116 bits (291), Expect = 5e-26 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 2/203 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I++M+ L+ H+N++ + A E + + ME GGELF+RI+ H +E R Sbjct: 342 IEVMNQLN-HRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQ 400 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I + H + V+H DLKPEN L N L +K IDFGL+ + P + G+P + Sbjct: 401 ICDGILFMHKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEF 459 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 ++PEV+ + + D+W+ GVI Y+LLSG+ PF + + VL G FD E + Sbjct: 460 LSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEA 519 Query: 583 ISDSAKDLITRMLNPRPAERLTA 651 +SD AKD ++ ++ R++A Sbjct: 520 VSDEAKDFVSNLIVKEQGARMSA 542
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 115 bits (289), Expect = 9e-26 Identities = 72/202 (35%), Positives = 112/202 (55%), Gaps = 2/202 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +QIM L H +++ + E + +++V E GE+FD + G +E +A I Sbjct: 68 VQIMKMLD-HPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQI 126 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V+ CH ++HRDLK EN LL D+++++K DF FFK G++ GSP Y Sbjct: 127 LSAVDYCHGRKIVHRDLKAENLLL---DNNMNIKIADFSFGNFFKSGELLATWRGSPPYA 183 Query: 409 APEVL-CKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 APEV ++Y GP+ D+W+ GV+LY+L+ G PF T + VL+G P+ Sbjct: 184 APEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRI---PY-F 239 Query: 583 ISDSAKDLITRMLNPRPAERLT 648 +S+ + LI RML P++RLT Sbjct: 240 MSEDCEHLIRRMLVLDPSKRLT 261
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 115 bits (289), Expect = 9e-26 Identities = 72/193 (37%), Positives = 97/193 (50%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + +VME +GGELFD I + G E +A L + I+ V+ CH Sbjct: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHR 132 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 133 HMVVHRDLKPENVLL---DAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W+ GVILY LL G PF E +F + GV ++ S L+ Sbjct: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSIATLL 245 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 246 MHMLQVDPLKRAT 258
>MKNK1_RAT (Q4G050) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 413 Score = 115 bits (289), Expect = 9e-26 Identities = 69/230 (30%), Positives = 115/230 (50%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++ ++ G++N++ + +ED ++V E GG + I +R H++E +A+ + R + Sbjct: 83 VETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDV 142 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVV------ 390 ++ H+ G+ HRDLKPEN L + + +K DF L K T + Sbjct: 143 ATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTT 202 Query: 391 --GSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------WAE-- 513 GS Y+APEV+ Y D+W+ GV+LYI+LSG PPF W Sbjct: 203 PCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGE 262 Query: 514 ----TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F+++ +G +F + W IS AKDLI+++L +RL+A Sbjct: 263 VCRMCQNKLFESIQEGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSA 312
>LIN2_CAEEL (P54936) Protein lin-2 (Abnormal cell lineage protein 2)| Length = 961 Score = 115 bits (289), Expect = 9e-26 Identities = 70/222 (31%), Positives = 122/222 (54%), Gaps = 7/222 (3%) Frame = +1 Query: 13 HKGRTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH- 189 H G D I+I +L H + ++ Y HI+ E G ++ I+QR Sbjct: 56 HTGLGFEEIDEEIRICQNLQ-HPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASN 114 Query: 190 ---YSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF 360 +SE + TR ++ ++ CH+ ++HRD++P N +LA+KD LK FG++ Sbjct: 115 GFVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDL 174 Query: 361 KP--GQIFTDVVGSPYYVAPEVLCK-KYGPEADVWTAGVILYILLSGVPPFWAETQQGIF 531 G + VG P ++APE++ K + +D+W++GV+L++LL+G PF T I+ Sbjct: 175 SEIGGSMACGRVGVPQFMAPEIVRKDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSD-IY 233 Query: 532 DAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 + +++ +D D P IS+SA++L+ RMLN P++R++A E Sbjct: 234 ERIMQTDVDVDGY-MPNISESARNLVRRMLNADPSKRISAKE 274
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 115 bits (288), Expect = 1e-25 Identities = 69/193 (35%), Positives = 100/193 (51%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + +VME +GGELFD I + G E+++ L + I+ V+ CH Sbjct: 75 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 134 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 135 HMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 191 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W++GVILY LL G PF + +F + G+ ++ S L+ Sbjct: 192 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ----YLNPSVISLL 247 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 248 KHMLQVDPMKRAT 260
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 115 bits (288), Expect = 1e-25 Identities = 69/193 (35%), Positives = 100/193 (51%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + +VME +GGELFD I + G E+++ L + I+ V+ CH Sbjct: 75 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 134 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 135 HMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 191 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W++GVILY LL G PF + +F + G+ ++ S L+ Sbjct: 192 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ----YLNPSVISLL 247 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 248 KHMLQVDPMKRAT 260
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 115 bits (288), Expect = 1e-25 Identities = 69/193 (35%), Positives = 100/193 (51%), Gaps = 2/193 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + +VME +GGELFD I + G E+++ L + I+ V+ CH Sbjct: 73 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 132 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 133 HMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W++GVILY LL G PF + +F + G+ ++ S L+ Sbjct: 190 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ----YLNPSVISLL 245 Query: 610 TRMLNPRPAERLT 648 ML P +R T Sbjct: 246 KHMLQVDPMKRAT 258
>KGP2_RAT (Q64595) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 115 bits (288), Expect = 1e-25 Identities = 67/190 (35%), Positives = 104/190 (54%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D YV++++E C GGEL+ + RG + E + + + H LG+ Sbjct: 513 IVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGI 572 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L D D LK +DFG + GQ G+P YVAPEV+ K + Sbjct: 573 IYRDLKPENLIL---DADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDF 629 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 D W+ G+++Y LL+G PPF Q ++ +LKG+ +DF + I+ +DLI R Sbjct: 630 SVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRK----ITRRPEDLIRR 685 Query: 616 MLNPRPAERL 645 + P ERL Sbjct: 686 LCRQNPTERL 695
>MKNK2_XENTR (Q66I46) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 466 Score = 115 bits (288), Expect = 1e-25 Identities = 72/230 (31%), Positives = 115/230 (50%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +++++ GH NV+ + +E++ ++V E GG + + I +R H++ER+A+ + R I Sbjct: 129 VEMLYQCQGHSNVLELIEFFEEEDKFYLVFEKMCGGSILNHIHRRRHFNEREASFVVRDI 188 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV------- 387 + H+ G+ HRDLKPEN L + +K DF L K + + Sbjct: 189 AEALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIKLNSDCSPISTPELLT 248 Query: 388 -VGSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------W---- 507 GS Y+APEV+ Y D+W+ GVILYI+LSG PPF W Sbjct: 249 PCGSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGHCGSDCGWDRGE 308 Query: 508 --AETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F ++ +G +F + W IS AKDLI+++L +RL+A Sbjct: 309 ACPACQNMLFVSIQEGKYEFPEKDWAHISSGAKDLISKLLLRDAKKRLSA 358
>MKNK2_RAT (Q5U2N4) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 115 bits (287), Expect = 1e-25 Identities = 70/230 (30%), Positives = 118/230 (51%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +++++ GH+NV+ + +E++ ++V E GG + I +R H++E +A+ + + + Sbjct: 130 VEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELEASVVVQDV 189 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV------- 387 ++ H+ G+ HRDLKPEN L + + +K DF L K + + Sbjct: 190 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT 249 Query: 388 -VGSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------W---- 507 GS Y+APEV+ Y D+W+ GVILYILLSG PPF W Sbjct: 250 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGE 309 Query: 508 --AETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F+++ +G +F + W IS +AKDLI+++L +RL+A Sbjct: 310 ACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSA 359
>MKNK2_MOUSE (Q8CDB0) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 115 bits (287), Expect = 1e-25 Identities = 70/230 (30%), Positives = 118/230 (51%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +++++ GH+NV+ + +E++ ++V E GG + I +R H++E +A+ + + + Sbjct: 130 VEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELEASVVVQDV 189 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV------- 387 ++ H+ G+ HRDLKPEN L + + +K DF L K + + Sbjct: 190 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT 249 Query: 388 -VGSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------W---- 507 GS Y+APEV+ Y D+W+ GVILYILLSG PPF W Sbjct: 250 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGE 309 Query: 508 --AETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F+++ +G +F + W IS +AKDLI+++L +RL+A Sbjct: 310 ACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSA 359
>MYLK2_HUMAN (Q9H1R3) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 595 Score = 115 bits (287), Expect = 1e-25 Identities = 69/203 (33%), Positives = 109/203 (53%), Gaps = 2/203 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRG-HYSERKAAELTRI 225 I++M+ L+ H+N++ + A E + + ME GGELF+RI+ H +E R Sbjct: 330 IEVMNQLN-HRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQ 388 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I + H + V+H DLKPEN L N L +K IDFGL+ + P + G+P + Sbjct: 389 ICDGILFMHKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEF 447 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 ++PEV+ + + D+W+ GVI Y+LLSG+ PF + + VL G FD E + Sbjct: 448 LSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEA 507 Query: 583 ISDSAKDLITRMLNPRPAERLTA 651 +SD AKD ++ ++ R+ A Sbjct: 508 VSDEAKDFVSNLIVKDQRARMNA 530
>KGP2_MOUSE (Q61410) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 115 bits (287), Expect = 1e-25 Identities = 67/190 (35%), Positives = 104/190 (54%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D YV++++E C GGEL+ + RG + E + + + H LG+ Sbjct: 513 IVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHLLGI 572 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L D D LK +DFG + GQ G+P YVAPEV+ K + Sbjct: 573 IYRDLKPENLIL---DADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDF 629 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 D W+ G+++Y LL+G PPF Q ++ +LKG+ +DF + I+ +DLI R Sbjct: 630 SVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRK----ITRRPEDLIRR 685 Query: 616 MLNPRPAERL 645 + P ERL Sbjct: 686 LCRQNPTERL 695
>MKNK2_HUMAN (Q9HBH9) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 465 Score = 115 bits (287), Expect = 1e-25 Identities = 70/230 (30%), Positives = 118/230 (51%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +++++ GH+NV+ + +E++ ++V E GG + I +R H++E +A+ + + + Sbjct: 130 VEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDV 189 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV------- 387 ++ H+ G+ HRDLKPEN L + + +K DF L K + + Sbjct: 190 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT 249 Query: 388 -VGSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------W---- 507 GS Y+APEV+ Y D+W+ GVILYILLSG PPF W Sbjct: 250 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 309 Query: 508 --AETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F+++ +G +F + W IS +AKDLI+++L +RL+A Sbjct: 310 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSA 359
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 114 bits (286), Expect = 2e-25 Identities = 76/204 (37%), Positives = 101/204 (49%), Gaps = 10/204 (4%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + ++ME +GGELFD I++ G +A + I+ V+ CH Sbjct: 144 HPHIIRLYQVISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHR 203 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D+ ++K DFGLS G GSP Y APEV+ K Sbjct: 204 HMVVHRDLKPENLLL---DEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKL 260 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVI---DFDSEPWPVISDSAK 600 GPE DVW+ GVILY LL G PF E +F + GV DF P Sbjct: 261 YAGPEVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSGVFPTPDFLERP-------IV 313 Query: 601 DLITRMLNPRPAERLT-----AHE 657 +L+ ML P +R T AHE Sbjct: 314 NLLHHMLCVDPMKRATIKDVIAHE 337
>SAPKA_ORYSA (Q75H77) Serine/threonine-protein kinase SAPK10 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 10) Length = 362 Score = 114 bits (286), Expect = 2e-25 Identities = 75/205 (36%), Positives = 103/205 (50%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME +GGELF+RI G +SE +A + ++ Sbjct: 69 INHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS 128 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CHS+ V HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 129 GVSYCHSMQVCHRDLKLENTLLDGSTAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 187 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL KK G ADVW+ GV LY++L G PF + F ++ + + + + Sbjct: 188 EVLLKKEYDGKIADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVH 247 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS +DLI R+ PA R++ E Sbjct: 248 ISPECRDLIARIFVANPATRISIPE 272
>MKNK2_XENLA (Q6P431) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 467 Score = 114 bits (285), Expect = 3e-25 Identities = 72/230 (31%), Positives = 115/230 (50%), Gaps = 29/230 (12%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +++++ GH NV+ + +E++ ++V E GG + + I +R H++ER+A+ + R I Sbjct: 129 VEMLYQCQGHSNVLELIEFFEEEDKFYLVFEKMCGGSILNHIHRRRHFNEREASFVVRDI 188 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDV------- 387 + H+ G+ HRDLKPEN L + +K DF L K + + Sbjct: 189 AEALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIKLNSDCSPISTPELLT 248 Query: 388 -VGSPYYVAPEVL------CKKYGPEADVWTAGVILYILLSGVPPF---------W---- 507 GS Y+APEV+ Y D+W+ GVILYI+LSG PPF W Sbjct: 249 PCGSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGHCGSDCGWDRGE 308 Query: 508 --AETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 Q +F ++ +G +F + W IS AKDLI+++L +RL+A Sbjct: 309 ACPACQNMLFVSIQEGKYEFPEKDWAHISYGAKDLISKLLLRDAKKRLSA 358
>PLK1_CAEEL (P34331) Serine/threonine-protein kinase plk-1 (EC 2.7.11.21)| (Polo-like kinase 1) Length = 649 Score = 114 bits (285), Expect = 3e-25 Identities = 72/202 (35%), Positives = 106/202 (52%), Gaps = 1/202 (0%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 ++H GH N+V + +ED L V+I +ELCA L + +R +E +A T IV Sbjct: 89 LIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVD 148 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V H L ++HRD+K N L +DDL +K DFGL+ + + G+P Y+AP Sbjct: 149 GVLYLHDLNIIHRDMKLGNLFL---NDDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAP 205 Query: 415 EVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISD 591 EVL K + E D+W G ILYILL G PPF +++ + + + S + + Sbjct: 206 EVLNKAGHSFEVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTIPS----IATQ 261 Query: 592 SAKDLITRMLNPRPAERLTAHE 657 A LI +ML+P P R TA + Sbjct: 262 PAASLIRKMLDPEPTRRPTAKQ 283
>ASK2_ARATH (P43292) Serine/threonine-protein kinase ASK2 (EC 2.7.11.1)| Length = 353 Score = 114 bits (285), Expect = 3e-25 Identities = 74/205 (36%), Positives = 104/205 (50%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME +GGELFDRI G +SE +A + ++ Sbjct: 50 INHRSLKHPNIIRFKEVILTPTHLAIVMEYASGGELFDRICTAGRFSEAEARYFFQQLIC 109 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V+ CHSL + HRDLK EN LL L LK DFG S VG+P Y+AP Sbjct: 110 GVDYCHSLQICHRDLKLENTLLDGSPAPL-LKICDFGYSKSSILHSRPKSTVGTPAYIAP 168 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL ++ G ADVW+ GV LY++L G PF F ++ + + + + Sbjct: 169 EVLSRREYDGKHADVWSCGVTLYVMLVGAYPFEDPNDPKNFRKTIQRIMAVQYKIPDYVH 228 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS K L++R+ A+R+T E Sbjct: 229 ISQECKHLLSRIFVTNSAKRITLKE 253
>KGP2_HUMAN (Q13237) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 114 bits (285), Expect = 3e-25 Identities = 66/190 (34%), Positives = 104/190 (54%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D YV++++E C GGEL+ + RG + E + + + H LG+ Sbjct: 513 IVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGI 572 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L D + LK +DFG + GQ G+P YVAPEV+ K + Sbjct: 573 IYRDLKPENLIL---DAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDF 629 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 D W+ G+++Y LL+G PPF Q ++ +LKG+ +DF + I+ +DLI R Sbjct: 630 SVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRK----ITRRPEDLIRR 685 Query: 616 MLNPRPAERL 645 + P ERL Sbjct: 686 LCRQNPTERL 695
>KCC2_SCHPO (O42844) Calcium/calmodulin-dependent protein kinase type II (EC| 2.7.11.17) (CAM kinase II) Length = 504 Score = 114 bits (285), Expect = 3e-25 Identities = 79/234 (33%), Positives = 115/234 (49%), Gaps = 31/234 (13%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 + IM + HKNVV + E + + H+VMEL GGELF +I+ ++SE A + + Sbjct: 113 VNIMRRVK-HKNVVNLFDFVETEDFYHLVMELAEGGELFHQIVNFTYFSENLARHIIIQV 171 Query: 229 VGVVEACHSL-GVMHRDLKPENFLLA-----------------NK-DDDLSLKAI----- 336 V+ H + G++HRD+KPEN L NK D+ + L+ I Sbjct: 172 AEAVKHLHDVCGIVHRDIKPENLLFQPIEYLPSQNYTPPSLEPNKLDEGMFLEGIGAGGI 231 Query: 337 ------DFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGV 495 DFG S + T G+ Y APE++ + Y D+W G +L+ +L G Sbjct: 232 GRILIADFGFSKVVWNSKTATPC-GTVGYAAPEIVNDELYSKNVDMWAMGCVLHTMLCGF 290 Query: 496 PPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 PPF+ E + + V+ G +F S W ISDSAKDLIT +L P ER H+ Sbjct: 291 PPFFDENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPRERYDIHQ 344
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 114 bits (285), Expect = 3e-25 Identities = 69/215 (32%), Positives = 110/215 (51%), Gaps = 14/215 (6%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++++ L+ H +V +KG YED ++VME +GG+L D + G E E++R I Sbjct: 245 LEVLQKLN-HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQI 303 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + ++ HS+G+ HRDLKP+N L+ +DD + +K DFGL+ G G+ YV Sbjct: 304 LTAIKYIHSMGISHRDLKPDNILI-EQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYV 362 Query: 409 APEVLCKK--------------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLK 546 APEV+ K Y D+W+ G ++Y++L+G PF TQ ++ + + Sbjct: 363 APEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGR 422 Query: 547 GVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTA 651 G IS+ A+D I +L P R TA Sbjct: 423 GSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTA 457
>MYLK2_RAT (P20689) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 609 Score = 114 bits (284), Expect = 3e-25 Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 2/205 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHY-SERKAAELTRI 225 I++M+ L+ H+N++ + A E + + ME GGELF+RI+ + +E R Sbjct: 344 IEVMNQLN-HRNLIQLYSAIETSHEIILFMEYIEGGELFERIVDEDYQLTEVDTMVFVRQ 402 Query: 226 IVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYY 405 I + H + V+H DLKPEN L N L +K IDFGL+ + P + G+P + Sbjct: 403 ICDGILFMHKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEF 461 Query: 406 VAPEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 ++PEV+ + + D+W+ GVI Y+LLSG+ PF + + VL FD E + Sbjct: 462 LSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEA 521 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 +SD AKD ++ ++ + R++A + Sbjct: 522 VSDEAKDFVSNLITKDQSARMSAEQ 546
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 114 bits (284), Expect = 3e-25 Identities = 72/201 (35%), Positives = 102/201 (50%), Gaps = 4/201 (1%) Frame = +1 Query: 52 QIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIV 231 +IM +LS H VV + + V++V+E GG+L +RII SE + + Sbjct: 230 KIMKNLS-HPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMC 288 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVA 411 V+ H G+ HRDLKP+N LL D++ LK DFGLS F + + + G+P YVA Sbjct: 289 HAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVA 348 Query: 412 PEVLC----KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWP 579 PEVL + Y + D+W+ GV+L+ LSG PF E + KG + W Sbjct: 349 PEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWK 408 Query: 580 VISDSAKDLITRMLNPRPAER 642 +S AK LI +ML P R Sbjct: 409 SVSQRAKLLINQMLIVDPERR 429
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 114 bits (284), Expect = 3e-25 Identities = 68/191 (35%), Positives = 99/191 (51%), Gaps = 2/191 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H +++ + + +VME +GGELFD I + G E+++ L + I+ V+ CH Sbjct: 73 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 132 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKKY 435 V+HRDLKPEN LL D ++ K DFGLS G+ GSP Y APEV+ + Sbjct: 133 HMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 436 --GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE D+W++GVILY LL G PF + +F + G+ ++ S L+ Sbjct: 190 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ----YLNPSVISLL 245 Query: 610 TRMLNPRPAER 642 ML P +R Sbjct: 246 KHMLQVDPMKR 256
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 114 bits (284), Expect = 3e-25 Identities = 67/177 (37%), Positives = 97/177 (54%), Gaps = 4/177 (2%) Frame = +1 Query: 124 VHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLA 303 + +VMEL +GGELF I ++G R++ + I+ V CH+ ++HRDLKPEN LL Sbjct: 97 IFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNHMIVHRDLKPENLLL- 155 Query: 304 NKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK--YGPEADVWTAGVILY 477 D + ++K DFGLS + G + + GSP Y APE++ K GPE D+W+ GVILY Sbjct: 156 --DANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILY 213 Query: 478 ILLSGVPPFWAETQQGIFDAVLKG--VIDFDSEPWPVISDSAKDLITRMLNPRPAER 642 +L G PF + +F + G + + E A DLI+ ML P +R Sbjct: 214 AMLCGTLPFDDQNVPTLFAKIKSGRYTVPYSME------KQAADLISTMLQVDPVKR 264
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 113 bits (282), Expect = 6e-25 Identities = 65/196 (33%), Positives = 100/196 (51%), Gaps = 2/196 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H + + Y + ++V E GG++ D II G E++A + R I + H Sbjct: 200 HPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQARKFVRQIGSALSYLHQ 259 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK- 432 V+HRDLK EN L++ D +K IDFGLS ++ GS Y+ APE+L + Sbjct: 260 NSVVHRDLKIENILISKTGD---IKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQP 316 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 GPE DVW+ G++LY+L+ G PF + + + KG +++ S +S K L+ Sbjct: 317 YIGPEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIKKGTVEYPS----YLSSDCKGLL 372 Query: 610 TRMLNPRPAERLTAHE 657 +RML P +R T E Sbjct: 373 SRMLVTDPLKRATLEE 388
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 112 bits (281), Expect = 7e-25 Identities = 71/197 (36%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH-YSERKAAELTRIIVGVVEACH 252 H N+V + + Q +++++EL GG++FD I++ +E A + IV + CH Sbjct: 72 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 131 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLC-- 426 L V+HRDLKPEN + K +K DFG S F+PG+ T GS Y APE+L Sbjct: 132 KLHVVHRDLKPENVVFFEKQG--LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 189 Query: 427 KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 + P D+W+ GVIL++L+ G PPF Q+ L ++D P +S +DL Sbjct: 190 EYDAPAVDIWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPPRVSAGCRDL 245 Query: 607 ITRMLNPRPAERLTAHE 657 ITRML P R + E Sbjct: 246 ITRMLQRDPKRRASLEE 262
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 112 bits (281), Expect = 7e-25 Identities = 72/199 (36%), Positives = 109/199 (54%), Gaps = 5/199 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+V + + ++ VME GGELF+++ G E A + + +V V+ CHS Sbjct: 69 HPNIVELHEVMATKSKIYFVMEHVKGGELFNKV-STGKLREDVARKYFQQLVRAVDFCHS 127 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF---KPGQIFTDVVGSPYYVAPEVLC 426 GV HRDLKPEN LL D+ +LK DFGLS + + G+P YVAPEV+ Sbjct: 128 RGVCHRDLKPENLLL---DEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVIS 184 Query: 427 KK--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAK 600 + G +ADVW+ GVIL++LL+G PF ++ + K + F + W ++ AK Sbjct: 185 RNGYDGFKADVWSCGVILFVLLAGYLPFRDSNLMELYKKIGKAEVKFPN--W--LAPGAK 240 Query: 601 DLITRMLNPRPAERLTAHE 657 L+ R+L+P P R++ + Sbjct: 241 RLLKRILDPNPNTRVSTEK 259
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 112 bits (281), Expect = 7e-25 Identities = 71/197 (36%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH-YSERKAAELTRIIVGVVEACH 252 H N+V + + Q +++++EL GG++FD I++ +E A + IV + CH Sbjct: 72 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 131 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLC-- 426 L V+HRDLKPEN + K +K DFG S F+PG+ T GS Y APE+L Sbjct: 132 KLHVVHRDLKPENVVFFEKQG--LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 189 Query: 427 KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 + P D+W+ GVIL++L+ G PPF Q+ L ++D P +S +DL Sbjct: 190 EYDAPAVDIWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPPRVSAGCRDL 245 Query: 607 ITRMLNPRPAERLTAHE 657 ITRML P R + E Sbjct: 246 ITRMLQRDPKRRASLEE 262
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 112 bits (279), Expect = 1e-24 Identities = 68/201 (33%), Positives = 110/201 (54%), Gaps = 4/201 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 ++ L H NV+++ +E +++++E GELF+ ++ G ER+A R I+ Sbjct: 79 VIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIII 138 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 + CH+LG++HRDLKPEN LL D ++K DFG++ + GSP+Y AP Sbjct: 139 GISYCHALGIVHRDLKPENLLL---DSFYNIKIADFGMAALQTDADLLETSCGSPHYAAP 195 Query: 415 EVL--CKKYGPEADVWTAGVILYILLSGVPPFWAE--TQQGIFDAVLKGVIDFDSEPWPV 582 E++ G +DVW+ GVIL+ LL+G PF E + + V KG + ++ Sbjct: 196 EIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPND--TE 253 Query: 583 ISDSAKDLITRMLNPRPAERL 645 IS A+DLI ++L P +R+ Sbjct: 254 ISRDAQDLIGKILVVDPRQRI 274
>SAPK2_ORYSA (Q84TC6) Serine/threonine-protein kinase SAPK2 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 2) Length = 339 Score = 111 bits (278), Expect = 2e-24 Identities = 75/209 (35%), Positives = 109/209 (52%), Gaps = 7/209 (3%) Frame = +1 Query: 52 QIMHHLS-GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +IM+H S H N+V K ++ IVME AGGELF+RI G +SE +A + + Sbjct: 48 EIMNHRSLRHPNIVRFKEVVLTPTHLAIVMEYAAGGELFERICSAGRFSEDEARFFFQQL 107 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLS--LKAIDFGLSVFFKPGQIFTDVVGSPY 402 + V CHS+ + HRDLK EN LL D ++ LK DFG S VG+P Sbjct: 108 ISGVSYCHSMQICHRDLKLENTLL---DGSIAPRLKICDFGYSKSSLLHSQPKSTVGTPA 164 Query: 403 YVAPEVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSE 570 Y+APEVL +K G ADVW+ GV LY++L G PF + F + + + + Sbjct: 165 YIAPEVLARKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPRNFRKTITRILSVQYMVP 224 Query: 571 PWPVISDSAKDLITRMLNPRPAERLTAHE 657 + +S + L++R+ P +R+T E Sbjct: 225 DYVRVSMECRHLLSRIFVANPEQRITIPE 253
>CDR2_SCHPO (P87050) Mitosis inducer protein kinase cdr2 (EC 2.7.11.1)| Length = 775 Score = 111 bits (278), Expect = 2e-24 Identities = 65/203 (32%), Positives = 112/203 (55%), Gaps = 2/203 (0%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 ++ L H NV+ + Q + +V+E GGELFD ++++G ++E+ A+ I+ Sbjct: 60 VLLRLIEHPNVLQLIDVISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILC 119 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 +E CH L + HRDLKPEN L D S+K +FG++ +PG++ GSP+Y +P Sbjct: 120 GLEYCHKLHICHRDLKPENLYL---DAHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASP 176 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVIS 588 E++ + G +D+W+ G+I + LL+G PF + + + V +G + S IS Sbjct: 177 EIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIRSLLLKVCQGQFEMPSN----IS 232 Query: 589 DSAKDLITRMLNPRPAERLTAHE 657 A+ L+ RML+ + R+T + Sbjct: 233 PQAQHLLYRMLDVDSSTRITMEQ 255
>KGP24_DROME (Q03043) cGMP-dependent protein kinase, isozyme 2 forms| cD4/T1/T3A/T3B (EC 2.7.11.12) (CGK) (Foraging protein) Length = 1088 Score = 111 bits (277), Expect = 2e-24 Identities = 62/189 (32%), Positives = 108/189 (57%), Gaps = 2/189 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D+ Y++++ME C GGEL+ + +G++ + T +V + HS + Sbjct: 838 IVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNI 897 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN LL + +K +DFG + + G+ G+P YVAPEV+ + + Sbjct: 898 IYRDLKPENLLLNERG---YVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDI 954 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWP-VISDSAKDLITRM 618 AD W+ GV+++ LL+G PPF ++ +LKG+ D+ +P I+ +A +LI ++ Sbjct: 955 SADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGI---DAIEFPRNITRNASNLIKKL 1011 Query: 619 LNPRPAERL 645 PAERL Sbjct: 1012 CRDNPAERL 1020
>CAKI_DROME (Q24210) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CAKI) (Peripheral plasma membrane protein CaMGUK) Length = 898 Score = 111 bits (277), Expect = 2e-24 Identities = 71/207 (34%), Positives = 110/207 (53%), Gaps = 9/207 (4%) Frame = +1 Query: 64 HLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH----YSERKAAELTRIIV 231 H+ H ++V + Y + +++V E G +L +++R YSE A R I+ Sbjct: 67 HMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQIL 126 Query: 232 GVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFT----DVVGSP 399 + CH ++HRD++P LLA D+ +K FG S PG T VG P Sbjct: 127 EALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFG-SAIQLPGTRETIETHGRVGCP 185 Query: 400 YYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 +Y+APEV+ ++ YG DVW AGV+L++LLSG PF + + +V +G + F++ W Sbjct: 186 HYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVR-LQQSVARGRLSFEAPEW 244 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 IS +AKDL+ +ML P RL+ E Sbjct: 245 KSISANAKDLVMKMLAANPHHRLSITE 271
>KGP25_DROME (P32023) cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 (EC| 2.7.11.12) (CGK) (Foraging protein) Length = 934 Score = 111 bits (277), Expect = 2e-24 Identities = 62/189 (32%), Positives = 108/189 (57%), Gaps = 2/189 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D+ Y++++ME C GGEL+ + +G++ + T +V + HS + Sbjct: 684 IVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNI 743 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN LL + +K +DFG + + G+ G+P YVAPEV+ + + Sbjct: 744 IYRDLKPENLLLNERG---YVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDI 800 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWP-VISDSAKDLITRM 618 AD W+ GV+++ LL+G PPF ++ +LKG+ D+ +P I+ +A +LI ++ Sbjct: 801 SADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGI---DAIEFPRNITRNASNLIKKL 857 Query: 619 LNPRPAERL 645 PAERL Sbjct: 858 CRDNPAERL 866
>SAPK1_ORYSA (Q75LR7) Serine/threonine-protein kinase SAPK1 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 1) Length = 342 Score = 111 bits (277), Expect = 2e-24 Identities = 74/207 (35%), Positives = 105/207 (50%), Gaps = 5/207 (2%) Frame = +1 Query: 52 QIMHHLS-GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +IM+H S H N++ K ++ IVME AGGELF+RI G +SE +A + + Sbjct: 48 EIMNHRSLKHPNIIRFKEVVLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQL 107 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + V CHS+ V HRDLK EN LL LK DFG S VG+P Y+ Sbjct: 108 ISGVSYCHSMQVCHRDLKLENTLLDGSVTP-RLKICDFGYSKSSVLHSQPKSTVGTPAYI 166 Query: 409 APEVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APEVL +K G ADVW+ GV LY++L G PF F + + + + + Sbjct: 167 APEVLSRKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDDPRNFRKTITRILSVQYSIPDY 226 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S + L++R+ P +R+T E Sbjct: 227 VRVSADCRHLLSRIFVGNPEQRITIPE 253
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 111 bits (277), Expect = 2e-24 Identities = 71/197 (36%), Positives = 103/197 (52%), Gaps = 3/197 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH-YSERKAAELTRIIVGVVEACH 252 H N+V + + Q +++++EL GG++FD I++ +E A + IV + CH Sbjct: 72 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 131 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLC-- 426 L V+HRDLKPEN + K +K DFG S F+PG+ T GS Y APE+L Sbjct: 132 KLHVVHRDLKPENVVFFEKQG--LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 189 Query: 427 KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 + P D+W+ GVIL++L+ G PPF Q+ L ++D +S KDL Sbjct: 190 EYDAPAVDIWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPSHVSKECKDL 245 Query: 607 ITRMLNPRPAERLTAHE 657 ITRML P R + E Sbjct: 246 ITRMLQRDPKRRASLEE 262
>SAPK4_ORYSA (Q5N942) Serine/threonine-protein kinase SAPK4 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 4) Length = 360 Score = 111 bits (277), Expect = 2e-24 Identities = 73/205 (35%), Positives = 100/205 (48%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME AGGELFDRI RG +SE +A + ++ Sbjct: 50 INHRSLRHPNIIRFKEVILTPTHLMIVMEFAAGGELFDRICDRGRFSEDEARYFFQQLIC 109 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CH + + HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 110 GVSYCHHMQICHRDLKLENVLLDGSPAP-RLKICDFGYSKSSVLHSRPKSAVGTPAYIAP 168 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL ++ G ADVW+ GV LY++L G PF + ++ + + + + Sbjct: 169 EVLSRREYDGKLADVWSCGVTLYVMLVGAYPFEDQDDPKNIRKTIQRIMSVQYKIPDYVH 228 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS K LI R+ P R+T E Sbjct: 229 ISAECKQLIARIFVNNPLRRITMKE 253
>SAPK7_ORYSA (Q7XQP4) Serine/threonine-protein kinase SAPK7 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 7) Length = 359 Score = 111 bits (277), Expect = 2e-24 Identities = 72/205 (35%), Positives = 101/205 (49%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME AGGELFDRI G +SE +A + ++ Sbjct: 50 INHRSLRHPNIIRFKEVVVTPTHLAIVMEYAAGGELFDRICNAGRFSEDEARYFFQQLIC 109 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CH + + HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 110 GVSYCHFMQICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSLLHSKPKSTVGTPAYIAP 168 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL ++ G ADVW+ GV LY++L G PF F + + I + + Sbjct: 169 EVLSRREYDGKTADVWSCGVTLYVMLVGAYPFEDPDDPKNFRKTIGRIMSIQYKIPEYVH 228 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 +S + L++R+ PA+R+T E Sbjct: 229 VSQDCRQLLSRIFVANPAKRITIRE 253
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 110 bits (276), Expect = 3e-24 Identities = 79/230 (34%), Positives = 115/230 (50%), Gaps = 27/230 (11%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTR-- 222 ++IM L+ H N+V + E + ++++ME +GGE+FD ++ G E++A R Sbjct: 104 VRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQG 162 Query: 223 ---------------------IIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAID 339 IV V+ CH ++HRDLK EN LL D D+++K D Sbjct: 163 CQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLL---DADMNIKIAD 219 Query: 340 FGLSVFFKPGQIFTDVVGSPYYVAPEVLC-KKY-GPEADVWTAGVILYILLSGVPPFWAE 513 FG S F G GSP Y APE+ KKY GPE DVW+ GVILY L+SG PF + Sbjct: 220 FGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ 279 Query: 514 TQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 + + + VL+G I F +S ++L+ R L P +R T + Sbjct: 280 NLKELRERVLRGKYRIPF------YMSTDCENLLKRFLVLNPIKRGTLEQ 323
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 110 bits (275), Expect = 4e-24 Identities = 72/214 (33%), Positives = 111/214 (51%), Gaps = 14/214 (6%) Frame = +1 Query: 49 IQIMHHLSG--HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTR 222 I+I+ LS H+N+V + E +V++VME C GG+L D + Q+ +E Sbjct: 57 IKILKELSSLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVV 116 Query: 223 IIVGVVEACHSLGVMHRDLKPENFLLANKD-------DDLSLKAIDFGLSVFFKPGQIFT 381 I +EA + G++HRDLKP+N LL N D+ +K DFG + F G + Sbjct: 117 QIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAA 176 Query: 382 DVVGSPYYVAPEVLCK-KYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVID 558 + GSP Y+APEV+ +Y +AD+W+ G IL+ L+G PF A+T LK + Sbjct: 177 TLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQT-----PPQLKAYYE 231 Query: 559 FDSEPWPVI----SDSAKDLITRMLNPRPAERLT 648 E P I S + +DL+ R+L +R++ Sbjct: 232 KTRELRPNIPEWCSPNLRDLLLRLLKRNAKDRIS 265
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 110 bits (275), Expect = 4e-24 Identities = 64/200 (32%), Positives = 112/200 (56%), Gaps = 1/200 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++I HL H N++ + G + D V+++++ GGELF + + + ++++A + + Sbjct: 189 VEIQSHLR-HPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQL 247 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + CHS V+HRD+KPEN LL + + LK DFG SV P T + G+ Y+ Sbjct: 248 AEALLYCHSKKVIHRDIKPENLLLGSNGE---LKIADFGWSV-HAPSSRRTTLCGTLDYL 303 Query: 409 APEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 PE++ + + + D+W+ GV+ Y L G PPF +T Q + + K ++F P+ + Sbjct: 304 PPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISK--VEFQYPPY--V 359 Query: 586 SDSAKDLITRMLNPRPAERL 645 S+ AKDL++++L P RL Sbjct: 360 SEEAKDLVSKLLKHNPNHRL 379
>SAPK6_ORYSA (Q6ZI44) Serine/threonine-protein kinase SAPK6 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 6) Length = 365 Score = 109 bits (273), Expect = 6e-24 Identities = 72/205 (35%), Positives = 101/205 (49%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME AGGELFDRI G +SE ++ + ++ Sbjct: 50 INHRSLRHPNIIRFKEVVLTPTHLAIVMEYAAGGELFDRICSAGRFSEDESRYFFQQLIC 109 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CH + + HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 110 GVSYCHFMQICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSLLHSKPKSTVGTPAYIAP 168 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL ++ G ADVW+ GV LY++L G PF F + + I + + Sbjct: 169 EVLSRREYDGKMADVWSCGVTLYVMLVGAYPFEDPDDPKNFRKTIGRIVSIQYKIPEYVH 228 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS + L++R+ PA+R+T E Sbjct: 229 ISQDCRQLLSRIFVANPAKRITIRE 253
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 109 bits (273), Expect = 6e-24 Identities = 71/217 (32%), Positives = 114/217 (52%), Gaps = 23/217 (10%) Frame = +1 Query: 76 HKNVVAIKGAY-----EDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVV 240 H N+V + ++ + Q+ ++V+E GELF+RI+++ + ++ L + ++ + Sbjct: 257 HPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGL 316 Query: 241 EACHSLGVMHRDLKPENFLLA---------------NKDD-DLSLKAIDFGLSVFFKPGQ 372 + H ++HRD+KPEN LL ++D+ D+ +K DFGL+ F Q Sbjct: 317 KYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQ 376 Query: 373 IFTDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAET-QQGIFDAVLK 546 + G+P YVAPEVL KK Y + D+W+AGVILY+ L G PPF + + + +L+ Sbjct: 377 FTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQ 436 Query: 547 GVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 F S W I DS LI+ +L P ER E Sbjct: 437 AKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDE 473
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 109 bits (272), Expect = 8e-24 Identities = 75/213 (35%), Positives = 105/213 (49%), Gaps = 16/213 (7%) Frame = +1 Query: 67 LSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEA 246 LS H + + ++D ++ V+ L GEL D I + G ++E A +IV ++ Sbjct: 154 LSKHPGFIKLFYTFQDAHNLYFVLSLARNGELLDYINKLGRFNEICAQYYAALIVDSIDY 213 Query: 247 CHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFF---------------KPGQIFT 381 H GV+HRDLKPEN LL DD++ K DFG + KP Sbjct: 214 MHGRGVIHRDLKPENILL---DDNMRTKITDFGSAKILNSSHGSHEEDTHHADKPQAHSR 270 Query: 382 DVVGSPYYVAPEVLCKKY-GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVID 558 VG+ YV+PEVL K G +D+W G IL+ +L+G PPF A + F ++L Sbjct: 271 SFVGTARYVSPEVLSDKIAGTASDIWAFGCILFQMLAGKPPFVAGNEYLTFQSIL----H 326 Query: 559 FDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 E P ISD A DLI ++L P +RLT E Sbjct: 327 LSYEIPPDISDVASDLIKKLLVLDPKDRLTVDE 359
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 108 bits (271), Expect = 1e-23 Identities = 63/200 (31%), Positives = 111/200 (55%), Gaps = 1/200 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++I HL H N++ + G + D V+++++ GGELF + + + ++++A + + Sbjct: 189 VEIQSHLR-HPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQL 247 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + CHS V+HRD+KPEN LL + + LK DFG SV P T + G+ Y+ Sbjct: 248 AEALLYCHSKKVIHRDIKPENLLLGSNGE---LKIADFGWSV-HAPSSRRTTLCGTLDYL 303 Query: 409 APEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 PE++ + + D+W+ GV+ Y L G PPF +T Q + + K ++F P+ + Sbjct: 304 PPEMIEGRMHDETVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISK--VEFQYPPY--V 359 Query: 586 SDSAKDLITRMLNPRPAERL 645 S+ A+DL++++L P RL Sbjct: 360 SEEARDLVSKLLKHNPNHRL 379
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 108 bits (271), Expect = 1e-23 Identities = 62/195 (31%), Positives = 108/195 (55%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 HKN+ + G + D+ V+++ME GEL+ + G +E A+ + ++ HS Sbjct: 157 HKNLTQLYGFFYDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVYQMANALDYMHS 216 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 ++HRD+KPEN L+ + ++K DFG SV+ + GQ + G+ Y++PE++ ++ Sbjct: 217 KNILHRDIKPENILIGFNN---TIKLTDFGWSVYNEDGQKRKTLCGTIDYLSPELIKSRE 273 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y + DVW GV+ Y LL G PPF +T++ + +L+ + F +S A+DLI Sbjct: 274 YNNKVDVWALGVLTYELLVGSPPFEEDTKEMTYRRILRCDLKFPLN----VSPQARDLIV 329 Query: 613 RMLNPRPAERLTAHE 657 R+L P++R+ E Sbjct: 330 RLLQFEPSKRIPLSE 344
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 108 bits (271), Expect = 1e-23 Identities = 70/195 (35%), Positives = 104/195 (53%), Gaps = 4/195 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+++ + E + +V+E C GGELFD II + SE + + R IV V HS Sbjct: 66 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 125 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIF--TDVVGSPYYVAPEVLCK 429 G HRDLKPEN L D+ LK IDFGL K + + GS Y APE++ Sbjct: 126 QGYAHRDLKPENLLF---DEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQG 182 Query: 430 K--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 K G EADVW+ G++LY+L+ G PF + ++ +++G +D W +S S+ Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG--KYDVPKW--LSPSSIL 238 Query: 604 LITRMLNPRPAERLT 648 L+ +ML P +R++ Sbjct: 239 LLQQMLQVDPKKRIS 253
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 108 bits (270), Expect = 1e-23 Identities = 68/195 (34%), Positives = 106/195 (54%), Gaps = 4/195 (2%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H+++ + E + + +V+E C GGELFD II + SE + + R I+ V HS Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIF--TDVVGSPYYVAPEVLCK 429 G HRDLKPEN L D++ LK IDFGL K + + GS Y APE++ Sbjct: 126 QGYAHRDLKPENLLF---DENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQG 182 Query: 430 K--YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKD 603 K G EADVW+ G++LY+L+ G PF + ++ +++G ++ W +S S+ Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG--KYEVPKW--LSPSSIL 238 Query: 604 LITRMLNPRPAERLT 648 L+ +ML P +R++ Sbjct: 239 LLQQMLQVDPKKRIS 253
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 108 bits (270), Expect = 1e-23 Identities = 61/190 (32%), Positives = 105/190 (55%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D Y++++ME C GGEL+ + RG + + T +V HS G+ Sbjct: 420 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 479 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L ++ K +DFG + G+ G+P YVAPE++ K + Sbjct: 480 IYRDLKPENLILDHRG---YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 536 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 AD W+ G+++Y LL+G PPF ++ +L+G+ I+F + I+ +A +LI + Sbjct: 537 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK----IAKNAANLIKK 592 Query: 616 MLNPRPAERL 645 + P+ERL Sbjct: 593 LCRDNPSERL 602
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 108 bits (270), Expect = 1e-23 Identities = 61/190 (32%), Positives = 105/190 (55%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D Y++++ME C GGEL+ + RG + + T +V HS G+ Sbjct: 420 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 479 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L ++ K +DFG + G+ G+P YVAPE++ K + Sbjct: 480 IYRDLKPENLILDHRG---YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 536 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 AD W+ G+++Y LL+G PPF ++ +L+G+ I+F + I+ +A +LI + Sbjct: 537 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK----IAKNAANLIKK 592 Query: 616 MLNPRPAERL 645 + P+ERL Sbjct: 593 LCRDNPSERL 602
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 108 bits (270), Expect = 1e-23 Identities = 61/190 (32%), Positives = 105/190 (55%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D Y++++ME C GGEL+ + RG + + T +V HS G+ Sbjct: 420 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 479 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L ++ K +DFG + G+ G+P YVAPE++ K + Sbjct: 480 IYRDLKPENLILDHRG---YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 536 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 AD W+ G+++Y LL+G PPF ++ +L+G+ I+F + I+ +A +LI + Sbjct: 537 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK----IAKNAANLIKK 592 Query: 616 MLNPRPAERL 645 + P+ERL Sbjct: 593 LCRDNPSERL 602
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 108 bits (270), Expect = 1e-23 Identities = 61/190 (32%), Positives = 105/190 (55%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D Y++++ME C GGEL+ + RG + + T +V HS G+ Sbjct: 436 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 495 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L ++ K +DFG + G+ G+P YVAPE++ K + Sbjct: 496 IYRDLKPENLILDHRG---YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 552 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 AD W+ G+++Y LL+G PPF ++ +L+G+ I+F + I+ +A +LI + Sbjct: 553 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK----IAKNAANLIKK 608 Query: 616 MLNPRPAERL 645 + P+ERL Sbjct: 609 LCRDNPSERL 618
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 108 bits (270), Expect = 1e-23 Identities = 61/190 (32%), Positives = 105/190 (55%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D Y++++ME C GGEL+ + RG + + T +V HS G+ Sbjct: 436 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 495 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L ++ K +DFG + G+ G+P YVAPE++ K + Sbjct: 496 IYRDLKPENLILDHRG---YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 552 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 AD W+ G+++Y LL+G PPF ++ +L+G+ I+F + I+ +A +LI + Sbjct: 553 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK----IAKNAANLIKK 608 Query: 616 MLNPRPAERL 645 + P+ERL Sbjct: 609 LCRDNPSERL 618
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 108 bits (270), Expect = 1e-23 Identities = 61/190 (32%), Positives = 105/190 (55%), Gaps = 3/190 (1%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V + ++D Y++++ME C GGEL+ + RG + + T +V HS G+ Sbjct: 436 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 495 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGP 441 ++RDLKPEN +L ++ K +DFG + G+ G+P YVAPE++ K + Sbjct: 496 IYRDLKPENLILDHRG---YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 552 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPVISDSAKDLITR 615 AD W+ G+++Y LL+G PPF ++ +L+G+ I+F + I+ +A +LI + Sbjct: 553 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK----IAKNAANLIKK 608 Query: 616 MLNPRPAERL 645 + P+ERL Sbjct: 609 LCRDNPSERL 618
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 108 bits (269), Expect = 2e-23 Identities = 64/180 (35%), Positives = 104/180 (57%), Gaps = 1/180 (0%) Frame = +1 Query: 85 VVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGV 264 +V ++ +++D Y+++VME GGE+F R+ + G +SE A +V V+ HSL + Sbjct: 103 LVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDL 162 Query: 265 MHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPE-VLCKKYGP 441 +HRDLKPEN L+ D L+ DFG + K G+ +T + G+P Y+APE +L K Y Sbjct: 163 IHRDLKPENLLI---DQQGYLQVTDFGFAKRVK-GRTWT-LCGTPEYLAPEIILSKGYNK 217 Query: 442 EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRML 621 D W GV++Y + G PPF+A+ I++ ++ G + F S+ +S K L+ +L Sbjct: 218 AVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSK----LSSDLKHLLRSLL 273
>SAPK8_ORYSA (Q7Y0B9) Serine/threonine-protein kinase SAPK8 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 8) Length = 371 Score = 107 bits (268), Expect = 2e-23 Identities = 75/205 (36%), Positives = 105/205 (51%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME +GGELF+RI + +SE +A + ++ Sbjct: 79 INHRSLKHPNIIRFKEVILTPTHLAIVMEYASGGELFERICKNVRFSEDEARYFFQQLIS 138 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CHS+ V HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 139 GVSYCHSMQVCHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 197 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFD-SEPWPV- 582 EVL KK G ADVW+ GV LY+++ G PF + F ++ +++ S P V Sbjct: 198 EVLLKKEYDGKTADVWSCGVTLYVMVVGAYPFEDPEEPKNFRKTIQRILNVQYSIPENVD 257 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS + LI+R+ P+ R+T E Sbjct: 258 ISPECRHLISRIFVGDPSLRITIPE 282
>ASK1_ARATH (P43291) Serine/threonine-protein kinase ASK1 (EC 2.7.11.1)| Length = 363 Score = 107 bits (268), Expect = 2e-23 Identities = 69/205 (33%), Positives = 102/205 (49%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ I ME AGGELF+RI G +SE +A + ++ Sbjct: 50 INHRSLRHPNIIRFKEVVLTPTHLAIAMEYAAGGELFERICSAGRFSEDEARYFFQQLIS 109 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CH++ + HRDLK EN LL LK DFG S VG+P Y+AP Sbjct: 110 GVSYCHAMQICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSLLHSRPKSTVGTPAYIAP 168 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL ++ G ADVW+ GV LY++L G PF + F ++ + + + + Sbjct: 169 EVLSRREYDGKMADVWSCGVTLYVMLVGAYPFEDQEDPKNFRKTIQKIMAVQYKIPDYVH 228 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 IS K+L++R+ +R+T E Sbjct: 229 ISQDCKNLLSRIFVANSLKRITIAE 253
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 107 bits (268), Expect = 2e-23 Identities = 68/202 (33%), Positives = 99/202 (49%), Gaps = 8/202 (3%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV +E+ + IVME GG+L D +I G E+ L + ++ + H Sbjct: 228 HPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHK 287 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 GV HRD+KPEN L+ N D LK DFGL+ V G G+ Y+APEVL K Sbjct: 288 QGVTHRDIKPENILITN---DFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSK 344 Query: 433 -------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISD 591 Y + D+W+ G +LY++L+ PF + +Q + + KG + IS+ Sbjct: 345 NVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISE 404 Query: 592 SAKDLITRMLNPRPAERLTAHE 657 DLI RML P +R++ E Sbjct: 405 EGIDLINRMLEINPEKRISESE 426
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 107 bits (267), Expect = 3e-23 Identities = 59/156 (37%), Positives = 92/156 (58%), Gaps = 4/156 (2%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 I+I+ H N++ +K YE+ +++V EL GGEL DRI+++ +SER+A + + Sbjct: 458 IEILRRYGQHPNIITLKDVYEECNSIYLVTELMRGGELLDRILRQKFFSEREACSVLFTV 517 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKD-DDLSLKAIDFGLSVFFKP--GQIFTDVVGSP 399 VE HS GV+HRDLKP N L ++ D S++ DFG S + G + T + Sbjct: 518 CKTVEYLHSQGVVHRDLKPSNILYVDESGDPESIRICDFGFSKQLRAENGLLMTPCY-TA 576 Query: 400 YYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPF 504 +VAPEVL ++ Y D+W+ G++LY +L+G PF Sbjct: 577 NFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF 612 Score = 77.8 bits (190), Expect = 3e-14 Identities = 52/192 (27%), Positives = 99/192 (51%), Gaps = 2/192 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H VV + A++ + ++++++ GG+LF R+ + ++E + ++ HS Sbjct: 121 HPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLS-VFFKPGQIFTDVVGSPYYVAPEVLCKK 432 LG+++RDLKPEN LL D++ +K DFGLS + G+ Y+APEV+ ++ Sbjct: 181 LGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237 Query: 433 -YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLI 609 + AD W+ GV+++ +L+G PF + ++ +LK + +S+ A+ L+ Sbjct: 238 GHSHGADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ----FLSNEAQSLL 293 Query: 610 TRMLNPRPAERL 645 + RL Sbjct: 294 RALFKRNATNRL 305
>CHK1_USTMA (P0C198) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 662 Score = 107 bits (267), Expect = 3e-23 Identities = 73/188 (38%), Positives = 106/188 (56%), Gaps = 9/188 (4%) Frame = +1 Query: 112 DQLYV---HIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLK 282 DQ YV ++V+EL AGG+LFD+I E A + ++ +E HS GV HRD+K Sbjct: 136 DQNYVPGLYMVLELGAGGDLFDKIAPDYGVEEDLAHFYFQQLLAGLEYIHSQGVTHRDIK 195 Query: 283 PENFLLANKDDDLSLKAIDFGLSVFFK---PGQIFTDVVGSPYYVAPEVLCKKY-GPEAD 450 PEN LL D + +LK DFGL +K + T GS Y+APE+ K Y G D Sbjct: 196 PENMLL---DAEGNLKIADFGLCSVYKYKGKERELTGACGSLPYIAPEMNGKPYRGEPVD 252 Query: 451 VWTAGVILYILLSGVPPFWAE--TQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLN 624 VW++GV+L+ +L G P W E ++ + A G + F+ +PWP I A L+ +M++ Sbjct: 253 VWSSGVVLFAMLVGSTP-WDEPTSRSPEYSAYRTGKL-FEYDPWPRIPQDALSLLKKMMH 310 Query: 625 PRPAERLT 648 P P +R+T Sbjct: 311 PTPEKRIT 318
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 107 bits (267), Expect = 3e-23 Identities = 62/178 (34%), Positives = 98/178 (55%), Gaps = 2/178 (1%) Frame = +1 Query: 121 YVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLL 300 + +++ E +GG+L D IIQ G E A + R I ++ H+ ++HRDLK EN ++ Sbjct: 197 HFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMI 256 Query: 301 ANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKKY-GPEADVWTAGVIL 474 ++ + +K IDFGLS F + GS Y+ APE+L + Y GPE D+W+ G++L Sbjct: 257 SSSGE---IKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVL 313 Query: 475 YILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLT 648 Y+L+ G PF E + + + KG +D+ S +S L+TRM+ P R T Sbjct: 314 YVLVCGKVPFDDENSSILHEKIKKGKVDYPSH----LSIEVISLLTRMIVVDPLRRAT 367
>MEK1_SCHPO (Q10292) Meiosis-specific serine/threonine-protein kinase mek1 (EC| 2.7.11.1) Length = 445 Score = 106 bits (265), Expect = 5e-23 Identities = 64/207 (30%), Positives = 102/207 (49%), Gaps = 13/207 (6%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N++ + Y + I E+ GG+LF + + G E + I+ ++ H Sbjct: 215 HPNIIKVNMEYNSETQFFIFEEMVTGGDLFSYLTKLGTVPEVTTLFIMFQILQGLKYLHE 274 Query: 256 LGVMHRDLKPENFLLANKDDDL-SLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK 432 ++HRDLK EN L+A+ D + + DFG++ + G+ + VG+P Y APE+ K Sbjct: 275 QNIIHRDLKLENILIASSSDTIFRIILTDFGVARCMQKGKRLSTFVGTPEYTAPEIQRLK 334 Query: 433 ------------YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPW 576 YG E D+W+ GVI+++LLSG P +A D V + +DF W Sbjct: 335 GRSQVEKENSSGYGKEVDLWSLGVIMFLLLSGNSPSFA-------DGVKEKQVDFRDPVW 387 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S AKDLI+ +L P +R T + Sbjct: 388 KSVSRQAKDLISNLLKTNPPDRFTVKQ 414
>RCK2_YEAST (P38623) Serine/threonine-protein kinase RCK2 (EC 2.7.11.1) (CAM| kinase-like protein kinase CLK1) Length = 610 Score = 106 bits (264), Expect = 7e-23 Identities = 77/250 (30%), Positives = 116/250 (46%), Gaps = 41/250 (16%) Frame = +1 Query: 16 KGRTSTTCDAXIQIMHHLSGHKNV-------VAIKGAYEDQLYVHIVMELCAGGELFDRI 174 KG+ ST + Q + ++ HK V VA E Y +I+ EL GGE+F I Sbjct: 220 KGKDSTKTSSRDQALKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEI 279 Query: 175 IQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLL------------ANKDDD 318 ++ ++SE + + + + V+ HSLGV+HRD+KPEN L K DD Sbjct: 280 VRLTYFSEDLSRHVIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTPSIKPKLRKSDD 339 Query: 319 LSLKA-------------------IDFGLS--VFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 KA DFGLS +F K + VG Y APEV+ + Sbjct: 340 PQTKADEGIFTPGVGGGGIGIVKLADFGLSKQIFSKNTKTPCGTVG---YTAPEVVKDEH 396 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y + D+W G +LY +L G PPF+ E + + + +G F W IS AK+ ++ Sbjct: 397 YSMKVDMWGIGCVLYTMLCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVS 456 Query: 613 RMLNPRPAER 642 ++L P++R Sbjct: 457 KLLELEPSKR 466
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 106 bits (264), Expect = 7e-23 Identities = 72/203 (35%), Positives = 101/203 (49%), Gaps = 5/203 (2%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 IQ+ +GHKN++ E+ + +V+E GG+LFD+I E A + Sbjct: 62 IQLHKLCNGHKNIIHFYNTAENPQWRWVVLEFAQGGDLFDKIEPDVGIDEDVAQFYFAQL 121 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK---PGQIFTDVVGSP 399 + + HS GV HRDLKPEN LL D + +LK DFG + F ++ VGSP Sbjct: 122 MEGISFMHSKGVAHRDLKPENILL---DYNGNLKISDFGFASLFSYKGKSRLLNSPVGSP 178 Query: 400 YYVAPEVLCKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVL--KGVIDFDSEP 573 Y APE+ + G + DVW+ G+IL+ LL G P W E D +L K P Sbjct: 179 PYAAPEITQQYDGSKVDVWSCGIILFALLLGNTP-WDEAISNTGDYLLYKKQCERPSYHP 237 Query: 574 WPVISDSAKDLITRMLNPRPAER 642 W ++S A +IT ML P +R Sbjct: 238 WNLLSPGAYSIITGMLRSDPFKR 260
>MAPK2_RABIT (P49139) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) (Fragments) Length = 330 Score = 105 bits (263), Expect = 9e-23 Identities = 64/151 (42%), Positives = 87/151 (57%), Gaps = 8/151 (5%) Frame = +1 Query: 82 NVVAIKGAYEDQLYVH-----IVMELCAGGELFDRIIQRGH--YSERKAAELTRIIVGVV 240 ++V I YE+ LY IVME GG LF RI RG ++ER+A+E+ + I + Sbjct: 82 HIVRIVDVYEN-LYAGRKCLLIVMECLDGGLLFSRIQDRGDQAFTEREASEIMKSIGEAI 140 Query: 241 EACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEV 420 + HS+ + HRD+KPEN L +K LK DFG + T +PYYVAPEV Sbjct: 141 QYLHSINIAHRDVKPENLLYTSKRPKAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 200 Query: 421 L-CKKYGPEADVWTAGVILYILLSGVPPFWA 510 L +KY D+W+ GVI+YILL G PPF++ Sbjct: 201 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYS 231
>MYLK2_MOUSE (Q8VCR8) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) (Fragment) Length = 240 Score = 105 bits (263), Expect = 9e-23 Identities = 62/178 (34%), Positives = 95/178 (53%), Gaps = 2/178 (1%) Frame = +1 Query: 130 IVMELCAGGELFDRIIQRG-HYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLAN 306 + ME GGELF+RI+ H +E R I + H + V+H DLKPEN L N Sbjct: 1 LFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVN 60 Query: 307 KDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKKYGPEADVWTAGVILYIL 483 L +K IDFGL+ + P + G+P +++PEV+ + + D+W+ GVI Y+L Sbjct: 61 TTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYML 119 Query: 484 LSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAERLTAHE 657 LSG+ PF + + VL FD E + +SD AKD ++ +L + R++A + Sbjct: 120 LSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTKDQSARMSAEQ 177
>SAPK3_ORYSA (Q75V63) Serine/threonine-protein kinase SAPK3 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 3) (Protein kinase REK) Length = 334 Score = 105 bits (263), Expect = 9e-23 Identities = 69/205 (33%), Positives = 102/205 (49%), Gaps = 4/205 (1%) Frame = +1 Query: 55 IMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVG 234 I H H N++ K ++ IVME AGGELF++I G +SE +A + ++ Sbjct: 51 INHRSLRHPNIIRFKEVCLTPTHLAIVMEYAAGGELFEQICTAGRFSEDEARYFFQQLIS 110 Query: 235 VVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAP 414 V CHSL + HRDLK EN LL +K DFG S VG+P Y+AP Sbjct: 111 GVSYCHSLEICHRDLKLENTLLDGSPTP-RVKICDFGYSKSALLHSKPKSTVGTPAYIAP 169 Query: 415 EVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPWPV 582 EVL +K G ADVW+ GV LY++L G PF F + + + + + Sbjct: 170 EVLSRKEYDGKVADVWSCGVTLYVMLVGSYPFEDPGDPRNFRKTISRILGVQYSIPDYVR 229 Query: 583 ISDSAKDLITRMLNPRPAERLTAHE 657 +S + L++++ P++R+T E Sbjct: 230 VSSDCRRLLSQIFVADPSKRITIPE 254
>RCK1_YEAST (P38622) Serine/threonine-protein kinase RCK1 (EC 2.7.11.1)| Length = 512 Score = 105 bits (262), Expect = 1e-22 Identities = 64/200 (32%), Positives = 103/200 (51%), Gaps = 22/200 (11%) Frame = +1 Query: 109 EDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPE 288 E Y ++V EL GGE+FDRI+Q +SE A + + ++ H +G++HRD+KPE Sbjct: 204 ESANYYYLVTELVTGGEIFDRIVQLTCFSEDLARHVITQVAIAIKHMHYMGIVHRDVKPE 263 Query: 289 NFLLA-----------NKDDDLSL----------KAIDFGLSVFFKPGQIFTDVVGSPYY 405 N L K+D+ +L K +DFGL+ + T G+ Y Sbjct: 264 NLLFEPIPFYGLDGDMQKEDEFTLGVGGGGIGLVKLMDFGLAKKLRNNTAKTPC-GTIEY 322 Query: 406 VAPEVLC-KKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPV 582 VA EV K+Y + D+W+ G +L+ LL G PPF+ + ++ + + +G +F + W Sbjct: 323 VASEVFTSKRYSMKVDMWSIGCVLFTLLCGYPPFYEKNEKTLLKKISRGDYEFLAPWWDN 382 Query: 583 ISDSAKDLITRMLNPRPAER 642 IS AK+ +T +L P +R Sbjct: 383 ISSGAKNAVTHLLEVDPNKR 402
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 105 bits (262), Expect = 1e-22 Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 4/199 (2%) Frame = +1 Query: 58 MHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGV 237 +H H N+V +ED V+I++E+C G L + + +R +E + T I G Sbjct: 132 IHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGA 191 Query: 238 VEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGL-SVFFKPGQIFTDVVGSPYYVAP 414 ++ HS V+HRDLK N D + +LK DFGL +V + + G+P Y+AP Sbjct: 192 IKYMHSRRVIHRDLKLGNIFF---DSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAP 248 Query: 415 EVLCKKYGP---EADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 EVL K+ E D+W+ GV+LY LL G PPF A I++ + DF I Sbjct: 249 EVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERI--KCRDFSFPRDKPI 306 Query: 586 SDSAKDLITRMLNPRPAER 642 SD K LI +L+ P ER Sbjct: 307 SDEGKILIRDILSLDPIER 325
>AAIP_WHEAT (Q02066) Abscisic acid-inducible protein kinase (EC 2.7.11.1)| (Fragment) Length = 332 Score = 105 bits (261), Expect = 2e-22 Identities = 72/209 (34%), Positives = 106/209 (50%), Gaps = 7/209 (3%) Frame = +1 Query: 52 QIMHHLS-GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +IM+H S H N++ K ++ IVME +GGELF RI G +SE + + + Sbjct: 38 EIMNHRSLKHPNIIRFKEVVLTPTHLAIVMEYASGGELFQRICNAGRFSEDEGRFFFQQL 97 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLS--LKAIDFGLSVFFKPGQIFTDVVGSPY 402 + V CHS+ V HRDLK EN LL D ++ LK DFG S VG+P Sbjct: 98 ISGVSYCHSMQVCHRDLKLENTLL---DGSVAPRLKICDFGYSKSSVLHSQPKSTVGTPA 154 Query: 403 YVAPEVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSE 570 Y+APEVL ++ G ADVW+ GV LY++L G PF + F + + + + Sbjct: 155 YIAPEVLSRREYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPRNFRKTITRILSVQYSVP 214 Query: 571 PWPVISDSAKDLITRMLNPRPAERLTAHE 657 + +S L++R+ P +R+T E Sbjct: 215 DYVRVSMDCIHLLSRIFVGNPQQRITIPE 243
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 105 bits (261), Expect = 2e-22 Identities = 66/194 (34%), Positives = 107/194 (55%), Gaps = 3/194 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH-YSERKAAELTRIIVGVVEACH 252 H +++ + +ED YV++V+E+C GE+ + R +SE +A I+ + H Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCK 429 S G++HRDL N LL ++++K DFGL+ K P + + G+P Y++PE+ + Sbjct: 129 SHGILHRDLTLSNLLLTR---NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATR 185 Query: 430 K-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 +G E+DVW+ G + Y LL G PPF +T + L V+ D E +S AKDL Sbjct: 186 SAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKN----TLNKVVLADYEMPTFLSIEAKDL 241 Query: 607 ITRMLNPRPAERLT 648 I ++L PA+RL+ Sbjct: 242 IHQLLRRNPADRLS 255
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 104 bits (260), Expect = 2e-22 Identities = 62/204 (30%), Positives = 108/204 (52%), Gaps = 1/204 (0%) Frame = +1 Query: 49 IQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 ++I HL H N++ + G + D V++++E G ++ + + + E++ A + Sbjct: 173 VEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 231 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 + CHS V+HRD+KPEN LL + + LK DFG SV P T + G+ Y+ Sbjct: 232 ANALSYCHSKRVIHRDIKPENLLLGSNGE---LKIADFGWSV-HAPSSRRTTMCGTLDYL 287 Query: 409 APEVL-CKKYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVI 585 PE++ + + + D+W+ GV+ Y L G+PPF A T Q + + + F + Sbjct: 288 PPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPD----FV 343 Query: 586 SDSAKDLITRMLNPRPAERLTAHE 657 ++ A+DLI+R+L ++RLT E Sbjct: 344 TEGARDLISRLLKHNASQRLTLAE 367
>KGP1_DROME (Q03042) cGMP-dependent protein kinase, isozyme 1 (EC 2.7.11.12)| (CGK) Length = 768 Score = 104 bits (260), Expect = 2e-22 Identities = 61/181 (33%), Positives = 99/181 (54%), Gaps = 1/181 (0%) Frame = +1 Query: 106 YEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKP 285 + D+ YV++++E C GGE++ + RG + + A + ++ E H+ G+++RDLKP Sbjct: 526 FRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKP 585 Query: 286 ENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLCKK-YGPEADVWTA 462 EN +L D+ +K +DFG + G+P YVAPE++ K + D W Sbjct: 586 ENLML---DERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWAL 642 Query: 463 GVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLITRMLNPRPAER 642 G++++ LL+G PPF A ++ +LKG ID + P IS A LI R+ P+ER Sbjct: 643 GILIHELLNGTPPFSAPDPMQTYNLILKG-IDMIAFP-KHISRWAVQLIKRLCRDVPSER 700 Query: 643 L 645 L Sbjct: 701 L 701
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (Protein kinase PKX1) Length = 358 Score = 104 bits (259), Expect = 3e-22 Identities = 62/183 (33%), Positives = 99/183 (54%), Gaps = 1/183 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H ++ + + D+ +++++ME GGELF + RG +S + I+ +E HS Sbjct: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 +++RDLKPEN LL D D +K DFG + K + G+P Y+APEV+ K Sbjct: 166 KEIVYRDLKPENILL---DRDGHIKLTDFGFAK--KLVDRTWTLCGTPEYLAPEVIQSKG 220 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 +G D W G++++ +LSG PPF+ + GI+ +L G IDF + KDLI Sbjct: 221 HGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRH----LDFHVKDLIK 276 Query: 613 RML 621 ++L Sbjct: 277 KLL 279
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 103 bits (258), Expect = 3e-22 Identities = 60/176 (34%), Positives = 95/176 (53%), Gaps = 7/176 (3%) Frame = +1 Query: 22 RTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSER 201 ++ T I+I+ L H+N+VA+ E V++VME C GG+L D + SE Sbjct: 55 KSQTLLGKEIKILKELK-HENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSED 113 Query: 202 KAAELTRIIVGVVEACHSLGVMHRDLKPENFLLAN------KDDDLSLKAIDFGLSVFFK 363 + I G + HS G++HRDLKP+N LL+N ++ +K DFG + + + Sbjct: 114 TVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQ 173 Query: 364 PGQIFTDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGI 528 + + GSP Y+APEV+ + Y +AD+W+ G I+Y L+G PF A + Q + Sbjct: 174 SNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDL 229
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 103 bits (258), Expect = 3e-22 Identities = 65/194 (33%), Positives = 107/194 (55%), Gaps = 3/194 (1%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGH-YSERKAAELTRIIVGVVEACH 252 H +V+ + +ED YV++V+E+C GE+ + R +SER+A I+ + H Sbjct: 69 HPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLH 128 Query: 253 SLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFK-PGQIFTDVVGSPYYVAPEVLCK 429 S G++HRDL N LL ++++K DFGL+ P + + G+P Y++PE+ + Sbjct: 129 SHGILHRDLTLSNILLTR---NMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATR 185 Query: 430 K-YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDL 606 +G E+D+W+ G + Y LL G PPF +T + L V+ D E +S A+DL Sbjct: 186 SAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKN----TLNKVVLADYEMPAFLSREAQDL 241 Query: 607 ITRMLNPRPAERLT 648 I ++L PA+RL+ Sbjct: 242 IHQLLRRNPADRLS 255
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 103 bits (258), Expect = 3e-22 Identities = 57/195 (29%), Positives = 103/195 (52%), Gaps = 1/195 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H N+ + G + D+ V+++ME GEL+ + R H+++ A+ + ++ H Sbjct: 166 HPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHE 225 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 ++HRD+KPEN ++ + ++K DFG SV G + G+ Y++PE++ ++ Sbjct: 226 RNILHRDIKPENIIIGFNN---TIKLTDFGWSVITPKGSKRKTLCGTVDYLSPELIRSRE 282 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 Y + DVW GV+ Y LL G PPF E+++ + +LK + F + A+ LI+ Sbjct: 283 YNEKVDVWALGVLTYELLVGSPPFEEESKELTYKRILKRNLIFPDH----VDTEARHLIS 338 Query: 613 RMLNPRPAERLTAHE 657 R+L P +R+ E Sbjct: 339 RLLEYDPGDRIPLKE 353
>SAPK5_ORYSA (Q7XKA8) Serine/threonine-protein kinase SAPK5 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 5) Length = 370 Score = 103 bits (257), Expect = 5e-22 Identities = 69/207 (33%), Positives = 105/207 (50%), Gaps = 5/207 (2%) Frame = +1 Query: 52 QIMHHLS-GHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRII 228 +I++H S H N++ K ++ IVME AGGELF+RI + G + E +A + + Sbjct: 48 EIVNHRSLRHPNIIRFKEVVVTGRHLAIVMEYAAGGELFERICEAGRFHEDEARYFFQQL 107 Query: 229 VGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYV 408 V V CH++ + HRDLK EN LL LK DFG S VG+P Y+ Sbjct: 108 VCGVSYCHAMQICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSLLHSRPKSTVGTPAYI 166 Query: 409 APEVLCKKY--GPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGV--IDFDSEPW 576 APEVL ++ G ADVW+ GV LY++L G PF F + + + + + Sbjct: 167 APEVLSRREYDGKLADVWSCGVTLYVMLVGAYPFEDPKDPKNFRKTISRIMSVQYKIPEY 226 Query: 577 PVISDSAKDLITRMLNPRPAERLTAHE 657 +S + L++R+ P +R++ E Sbjct: 227 VHVSQPCRHLLSRIFVANPYKRISMGE 253
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 103 bits (257), Expect = 5e-22 Identities = 64/191 (33%), Positives = 109/191 (57%), Gaps = 1/191 (0%) Frame = +1 Query: 76 HKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHS 255 H V++++ + +D ++++ + GGELF + G ++ + + IV +E HS Sbjct: 331 HPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHS 390 Query: 256 LGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-CKK 432 L +++RDLKPEN LL N+D LK DFG + + + +T + G+P Y+APE++ K Sbjct: 391 LQIVYRDLKPEN-LLINRDG--HLKITDFGFAKKLR-DRTWT-LCGTPEYIAPEIIQSKG 445 Query: 433 YGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGVIDFDSEPWPVISDSAKDLIT 612 + D W GV++Y +L G PPF+ E GI++ +L G I+++ P+ AKDLI Sbjct: 446 HNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPI----AKDLIK 501 Query: 613 RMLNPRPAERL 645 ++L +RL Sbjct: 502 KLLVNDRTKRL 512
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 103 bits (257), Expect = 5e-22 Identities = 60/176 (34%), Positives = 95/176 (53%), Gaps = 7/176 (3%) Frame = +1 Query: 22 RTSTTCDAXIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSER 201 ++ T I+I+ L H+N+VA+ E V++VME C GG+L D + SE Sbjct: 55 KSQTLLGKEIKILKELK-HENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSED 113 Query: 202 KAAELTRIIVGVVEACHSLGVMHRDLKPENFLLAN------KDDDLSLKAIDFGLSVFFK 363 + I G + HS G++HRDLKP+N LL+N + + +K DFG + + + Sbjct: 114 TIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQ 173 Query: 364 PGQIFTDVVGSPYYVAPEVLCKK-YGPEADVWTAGVILYILLSGVPPFWAETQQGI 528 + + GSP Y+APEV+ + Y +AD+W+ G I+Y L+G PF A + Q + Sbjct: 174 SNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDL 229 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 76,833,911 Number of Sequences: 219361 Number of extensions: 1552664 Number of successful extensions: 8778 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6303 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6659 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6257125380 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
