ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | baal6p06 |
|---|---|
| Clone Library Name | barley_pub |
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 86.3 bits (212), Expect = 6e-17 Identities = 51/148 (34%), Positives = 78/148 (52%), Gaps = 3/148 (2%) Frame = +1 Query: 142 ASDVGKKKKRDDPYVPVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLD--EIKEIT 315 A V KK+K+ + Y+ G+ + SV H + E P L + E T Sbjct: 798 ARKVQKKEKQREKYIESLPTSGSSSWKLSSV--HEPLSINVATFEKPLRKLTFAHLLEAT 855 Query: 316 KNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVI 492 FS+D++IG G + V+ L DG A+K+L + Q D+EF+ ++ + ++KH N++ Sbjct: 856 NGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETIGKIKHRNLV 915 Query: 493 QLLGYCALGSTRILAYEYATRGSLHDVL 576 LLGYC +G R+L YEY GSL VL Sbjct: 916 PLLGYCKIGEERLLVYEYMKYGSLETVL 943
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 85.5 bits (210), Expect = 1e-16 Identities = 39/94 (41%), Positives = 61/94 (64%), Gaps = 1/94 (1%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRL 474 ++ + T F +D+LIG G + V+ +LKDG A+K+L S Q D+EF+ ++ + ++ Sbjct: 875 DLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKI 934 Query: 475 KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 KH N++ LLGYC +G R+L YE+ GSL DVL Sbjct: 935 KHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVL 968
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 85.1 bits (209), Expect = 1e-16 Identities = 62/172 (36%), Positives = 84/172 (48%), Gaps = 19/172 (11%) Frame = +1 Query: 118 MGCFSCCGASDVGK----------KKKRDDPYVP-----VPAPGGNYGY--NRGSVPTHA 246 MGCFSC +SD K +KK+ P V +P+ G N GS Sbjct: 1 MGCFSCFDSSDDEKLNPVDESNHGQKKQSQPTVSNNISGLPSGGEKLSSKTNGGSKRELL 60 Query: 247 IRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKD-GKNSAVKRLD-S 420 + I E+ T NF D +GEG + RV+ G L G+ AVK+LD + Sbjct: 61 LPRDGLGQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRN 120 Query: 421 SKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 Q ++EFLV+V +S L H N++ L+GYCA G R+L YE+ GSL D L Sbjct: 121 GLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHL 172
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 84.7 bits (208), Expect = 2e-16 Identities = 44/143 (30%), Positives = 76/143 (53%), Gaps = 1/143 (0%) Frame = +1 Query: 151 VGKKKKRDDPYVPVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSS 330 V KK+++ + Y+ G+ + SVP + + + + E T FS+ Sbjct: 802 VQKKEQKREKYIESLPTSGSCSWKLSSVPEPLSINVATFEKPLRKLTFAHLLEATNGFSA 861 Query: 331 DALIGEGSYARVFLGVLKDGKNSAVKRLDS-SKQPDQEFLVQVSAVSRLKHDNVIQLLGY 507 + ++G G + V+ L+DG A+K+L + Q D+EF+ ++ + ++KH N++ LLGY Sbjct: 862 ETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGY 921 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 C +G R+L YEY GSL VL Sbjct: 922 CKVGEERLLVYEYMKWGSLETVL 944
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 84.3 bits (207), Expect = 2e-16 Identities = 40/94 (42%), Positives = 59/94 (62%), Gaps = 1/94 (1%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRL 474 ++ E T F +D+L+G G + V+ LKDG A+K+L S Q D+EF ++ + ++ Sbjct: 880 DLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKI 939 Query: 475 KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 KH N++ LLGYC +G R+L YEY GSL DVL Sbjct: 940 KHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVL 973
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 84.3 bits (207), Expect = 2e-16 Identities = 40/94 (42%), Positives = 59/94 (62%), Gaps = 1/94 (1%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRL 474 ++ E T F +D+L+G G + V+ LKDG A+K+L S Q D+EF ++ + ++ Sbjct: 880 DLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKI 939 Query: 475 KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 KH N++ LLGYC +G R+L YEY GSL DVL Sbjct: 940 KHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVL 973
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 84.0 bits (206), Expect = 3e-16 Identities = 39/98 (39%), Positives = 62/98 (63%), Gaps = 1/98 (1%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDS-SKQPDQEFLVQVSA 462 + ++ E T FS+ ++IG G + VF LKDG + A+K+L S Q D+EF+ ++ Sbjct: 826 LKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMET 885 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + ++KH N++ LLGYC +G R+L YE+ GSL +VL Sbjct: 886 LGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVL 923
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 80.9 bits (198), Expect = 2e-15 Identities = 59/189 (31%), Positives = 87/189 (46%), Gaps = 36/189 (19%) Frame = +1 Query: 118 MGCFSCC---------------------GASDVGKKKKRDD------------PYVPVPA 198 MGCF C G + V K KRDD PY V Sbjct: 1 MGCFGCSKKSSKRSETNKDTVINRKIVGGTTSVAKSDKRDDQTQPSSDSTKVSPYRDVNN 60 Query: 199 PGGNYGYNRGSVPTHAIRTS-RSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG 375 GG ++ S+ + + + + E+ E T NF SD +GEG + +VF G Sbjct: 61 EGGVGKEDQLSLDVKGLNLNDQVTGKKAQTFTFQELAEATGNFRSDCFLGEGGFGKVFKG 120 Query: 376 VL-KDGKNSAVKRLD-SSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYA 549 + K + A+K+LD + Q +EF+V+V +S H N+++L+G+CA G R+L YEY Sbjct: 121 TIEKLDQVVAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYM 180 Query: 550 TRGSLHDVL 576 +GSL D L Sbjct: 181 PQGSLEDHL 189
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 79.7 bits (195), Expect = 5e-15 Identities = 42/105 (40%), Positives = 66/105 (62%), Gaps = 1/105 (0%) Frame = +1 Query: 265 QPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLD-SSKQPDQE 441 + +E+P I ++ + + T+NFSS +G+G + V+ G L DGK AVKRL +S Q E Sbjct: 509 EELELPLIEMETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDE 568 Query: 442 FLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 F+ +V+ ++RL+H N++Q+LG C G ++L YEY SL L Sbjct: 569 FMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYL 613
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 79.0 bits (193), Expect = 9e-15 Identities = 40/97 (41%), Positives = 63/97 (64%), Gaps = 3/97 (3%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSS---KQPDQEFLVQVSAV 465 +E+++ T FS D+ +G+GS++ VF G+L+DG AVKR + K+ +EF ++ + Sbjct: 496 EELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNELDLL 555 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 SRL H +++ LLGYC GS R+L YE+ GSL+ L Sbjct: 556 SRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHL 592
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 75.1 bits (183), Expect = 1e-13 Identities = 35/94 (37%), Positives = 57/94 (60%), Gaps = 1/94 (1%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSK-QPDQEFLVQVSA 462 + L +I E T +FS +IG+G + V+ L K AVK+L +K Q ++EF+ ++ Sbjct: 905 VRLGDIVEATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMET 964 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 + ++KH N++ LLGYC+ ++L YEY GSL Sbjct: 965 LGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSL 998
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 72.8 bits (177), Expect = 7e-13 Identities = 33/96 (34%), Positives = 61/96 (63%), Gaps = 3/96 (3%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQ---EFLVQV 456 I + ++ +T NFSSD ++G G + V+ G L DG AVKR+++ + EF ++ Sbjct: 576 ISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEI 635 Query: 457 SAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 + +++++H +++ LLGYC G+ ++L YEY +G+L Sbjct: 636 AVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTL 671
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 71.2 bits (173), Expect = 2e-12 Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 1/94 (1%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSK-QPDQEFLVQVSA 462 + LD+I + T +F+ +IG G + V+ L DG A+KRL Q D+EF +V Sbjct: 731 LSLDDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVET 790 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 +SR +H N++ LLGYC + ++L Y Y GSL Sbjct: 791 LSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSL 824
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 70.5 bits (171), Expect = 3e-12 Identities = 38/106 (35%), Positives = 62/106 (58%), Gaps = 11/106 (10%) Frame = +1 Query: 292 LDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNS----------AVKRLDSSK-QPDQ 438 L E+K T+NF D+++GEG + VF G + + + AVKRL+ Q + Sbjct: 58 LSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQGHR 117 Query: 439 EFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 E+L +++ + +L H N+++L+GYC R+L YE+ TRGSL + L Sbjct: 118 EWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHL 163
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 68.9 bits (167), Expect = 1e-11 Identities = 32/93 (34%), Positives = 59/93 (63%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLK 477 E+ + T+ F + +G G V+ GVL+D ++ AVK+L++ +Q + F ++S + R+ Sbjct: 528 ELVKATRKFKVE--LGRGESGTVYKGVLEDDRHVAVKKLENVRQGKEVFQAELSVIGRIN 585 Query: 478 HDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 H N++++ G+C+ GS R+L EY GSL ++L Sbjct: 586 HMNLVRIWGFCSEGSHRLLVSEYVENGSLANIL 618
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 67.8 bits (164), Expect = 2e-11 Identities = 38/103 (36%), Positives = 62/103 (60%), Gaps = 1/103 (0%) Frame = +1 Query: 271 IEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVK-RLDSSKQPDQEFL 447 + V L+ I++ T+ + + LIGEG + V+ G L DG+ AVK R +S Q +EF Sbjct: 581 VSVKPFTLEYIEQATEQYKT--LIGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFD 638 Query: 448 VQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++ +S ++H+N++ LLGYC +IL Y + + GSL D L Sbjct: 639 NELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRL 681
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 67.0 bits (162), Expect = 4e-11 Identities = 37/104 (35%), Positives = 59/104 (56%), Gaps = 11/104 (10%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKD----------GKNSAVKRLDSSK-QPDQEF 444 E+K T+NF D+++GEG + VF G + + G AVK+L+ Q QE+ Sbjct: 61 ELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGWQGHQEW 120 Query: 445 LVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L +V+ + + H N+++L+GYC R+L YE+ RGSL + L Sbjct: 121 LAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHL 164
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 65.5 bits (158), Expect = 1e-10 Identities = 41/138 (29%), Positives = 70/138 (50%), Gaps = 14/138 (10%) Frame = +1 Query: 205 GNYGYNRGSVPTHAIRTSRSQPIEVP---AIPLDEIKEITKNFSSDALIGEGSYARVFLG 375 G+ G SV + + ++ P + E+K T+NF D+++GEG + VF G Sbjct: 26 GSLGSKASSVSVRPSPRTEGEILQSPNLKSFSFAELKSATRNFRPDSVLGEGGFGCVFKG 85 Query: 376 VLKD----------GKNSAVKRLDSSK-QPDQEFLVQVSAVSRLKHDNVIQLLGYCALGS 522 + + G AVK+L+ Q QE+L +V+ + + H ++++L+GYC Sbjct: 86 WIDEKSLTASRPGTGLVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDE 145 Query: 523 TRILAYEYATRGSLHDVL 576 R+L YE+ RGSL + L Sbjct: 146 HRLLVYEFMPRGSLENHL 163
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 65.1 bits (157), Expect = 1e-10 Identities = 38/103 (36%), Positives = 61/103 (59%), Gaps = 1/103 (0%) Frame = +1 Query: 271 IEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVK-RLDSSKQPDQEFL 447 + V L+ I+ T+ + + LIGEG + V+ G L DG+ AVK R +S Q +EF Sbjct: 580 VSVKPFTLEYIELATEKYKT--LIGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFD 637 Query: 448 VQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++ +S ++H+N++ LLGYC +IL Y + + GSL D L Sbjct: 638 NELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRL 680
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 64.3 bits (155), Expect = 2e-10 Identities = 47/138 (34%), Positives = 64/138 (46%), Gaps = 5/138 (3%) Frame = +1 Query: 178 PYVPVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSY 357 P P PAP SV ++ +R P PL EI T NFS + IGEG + Sbjct: 169 PPPPSPAPSSTKPGPESSVSL--LQGARPFPF---CWPLCEISRGTHNFSEELKIGEGGF 223 Query: 358 ARVFLGVLKDGKNSAVKRLDSSKQPD-----QEFLVQVSAVSRLKHDNVIQLLGYCALGS 522 V+ V+++ AVKRL + + Q FL +V +SR +H N++ GYCA Sbjct: 224 GCVYRAVMRNTVY-AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNG 282 Query: 523 TRILAYEYATRGSLHDVL 576 L Y + GSL D L Sbjct: 283 FYCLVYGFLPNGSLEDRL 300
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 63.9 bits (154), Expect = 3e-10 Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 5/135 (3%) Frame = +1 Query: 187 PVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARV 366 P+P+ + + P ++ + P P EI + T NFS + IGEG + V Sbjct: 170 PLPSSAPSSTKSSPESPVSGLQRAHPSPF---CWPFCEISQGTCNFSEELRIGEGGFGCV 226 Query: 367 FLGVLKDGKNSAVKRLDSSKQPD-----QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRI 531 + V+++ AVKRL + Q FL +V +SR +H N++ GYCA Sbjct: 227 YRAVMRN-TTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYC 285 Query: 532 LAYEYATRGSLHDVL 576 L Y + GSL D L Sbjct: 286 LVYGFLPNGSLEDQL 300
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 63.9 bits (154), Expect = 3e-10 Identities = 32/91 (35%), Positives = 51/91 (56%), Gaps = 1/91 (1%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSS-KQPDQEFLVQVSAVSR 471 D++ + T +F +IG G + V+ L DGK A+K+L Q ++EF +V +SR Sbjct: 725 DDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSR 784 Query: 472 LKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 +H N++ L G+C + R+L Y Y GSL Sbjct: 785 AQHPNLVLLRGFCFYKNDRLLIYSYMENGSL 815
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 61.6 bits (148), Expect = 2e-09 Identities = 32/97 (32%), Positives = 55/97 (56%), Gaps = 2/97 (2%) Frame = +1 Query: 292 LDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL--DSSKQPDQEFLVQVSAV 465 L E++ + NFS+ ++G G + +V+ G L DG AVKRL + ++ + +F +V + Sbjct: 279 LRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMI 338 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 S H N+++L G+C + R+L Y Y GS+ L Sbjct: 339 SMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCL 375
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 60.8 bits (146), Expect = 3e-09 Identities = 35/104 (33%), Positives = 57/104 (54%), Gaps = 11/104 (10%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLK----------DGKNSAVKRLDS-SKQPDQEF 444 ++K TKNF D+++G+G + +V+ G + G A+KRL+S S Q E+ Sbjct: 78 DLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQGFAEW 137 Query: 445 LVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +V+ + L H N+++LLGYC +L YE+ +GSL L Sbjct: 138 RSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHL 181
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 57.8 bits (138), Expect = 2e-08 Identities = 35/94 (37%), Positives = 55/94 (58%), Gaps = 1/94 (1%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRL 474 E+ IT NF + +IG+G + +V+ GV+ +G+ AVK L + S Q +EF +V + R+ Sbjct: 568 EVVNITNNF--ERVIGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDLLMRV 624 Query: 475 KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 H N+ L+GYC + +L YEY +L D L Sbjct: 625 HHTNLTSLVGYCNEINHMVLIYEYMANENLGDYL 658
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 55.8 bits (133), Expect = 8e-08 Identities = 27/93 (29%), Positives = 53/93 (56%), Gaps = 2/93 (2%) Frame = +1 Query: 304 KEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL--DSSKQPDQEFLVQVSAVSRLK 477 +++ + + +IG+G V+ G + + + A+KRL + + D F ++ + R++ Sbjct: 686 EDVLECLKEENIIGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIR 745 Query: 478 HDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 H ++++LLGY A T +L YEY GSL ++L Sbjct: 746 HRHIVRLLGYVANKDTNLLLYEYMPNGSLGELL 778
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 52.4 bits (124), Expect = 9e-07 Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +G G Y V++GV K AVK L +EFL + + + +KH N++QLLG C L Sbjct: 294 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTL 353 Query: 517 GSTRILAYEYATRGSLHDVL 576 + EY G+L D L Sbjct: 354 EPPFYIVTEYMPYGNLLDYL 373
>ATG1_KLULA (Q6CSX2) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 831 Score = 51.6 bits (122), Expect = 2e-06 Identities = 29/89 (32%), Positives = 53/89 (59%), Gaps = 5/89 (5%) Frame = +1 Query: 313 TKNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFL----VQVSAVSRLK 477 T+N+S + IG+GS+A V+ G+ L+DG+N A+K + SK +++ L V+++ + ++K Sbjct: 18 TENYSVEKEIGKGSFAVVYKGLSLRDGRNIAIKAVSRSKLKNKKLLENLEVEIAILKKIK 77 Query: 478 HDNVIQLLGYCALGSTRILAYEYATRGSL 564 H +++ L+ S L EY G L Sbjct: 78 HPHIVGLIDCERTSSDFYLIMEYCALGDL 106
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 51.2 bits (121), Expect = 2e-06 Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 11/101 (10%) Frame = +1 Query: 307 EITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSS-KQPDQE----------FLVQ 453 EI +IG GS +V+ L+ G+ AVK+L+ S K D E F + Sbjct: 678 EIADCLDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAE 737 Query: 454 VSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 V + ++H ++++L C+ G ++L YEY GSL DVL Sbjct: 738 VETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVL 778
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 50.8 bits (120), Expect = 3e-06 Identities = 26/97 (26%), Positives = 51/97 (52%), Gaps = 2/97 (2%) Frame = +1 Query: 292 LDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL--DSSKQPDQEFLVQVSAV 465 L+++ E T+N + +IG+G++ ++ L K AVK+L K + ++ + Sbjct: 806 LNKVLEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETI 865 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++H N+I+L + ++ Y Y GSLHD+L Sbjct: 866 GKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDIL 902
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 49.3 bits (116), Expect = 8e-06 Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNS--AVKRL--DSSKQPDQEFLVQVSAVSRLKHDNVIQ 495 +G+G++ RVF G++ D ++ AVK L D+S Q +F + ++ H N+++ Sbjct: 447 LGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVR 506 Query: 496 LLGYCALGSTRILAYEYATRGSLHDVL 576 LLG CALG L +EY G L + L Sbjct: 507 LLGVCALGRPMCLLFEYMAPGDLSEFL 533
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 49.3 bits (116), Expect = 8e-06 Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 5/109 (4%) Frame = +1 Query: 265 QPIEVPAIPLDEIKEITKNFSSDAL-----IGEGSYARVFLGVLKDGKNSAVKRLDSSKQ 429 +P+E P I L + S D++ +G G + V+ G+ + AVK L + Sbjct: 71 RPLERPQIDLSHKTKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTM 130 Query: 430 PDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 FL + + +L+H +IQL C G + E ++GSL D L Sbjct: 131 QPAAFLAEAQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYL 179
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 49.3 bits (116), Expect = 8e-06 Identities = 33/116 (28%), Positives = 64/116 (55%) Frame = +1 Query: 229 SVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVK 408 S + + +S S+ IE P+ L+ + K + ++G G++ V + K+ A+K Sbjct: 5 SAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWR-AKDVAIK 63 Query: 409 RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++S + + F+V++ +SR+ H N+++L G C + L EYA GSL++VL Sbjct: 64 QIESESER-KAFIVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVL 116
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 49.3 bits (116), Expect = 8e-06 Identities = 35/135 (25%), Positives = 63/135 (46%), Gaps = 5/135 (3%) Frame = +1 Query: 187 PVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEI---TKNFSSDALIGEGSY 357 P+PAP G+ + G+ + + E L I I K ++ IG+G+ Sbjct: 201 PIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGAS 260 Query: 358 ARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLV-QVSAVSRLKHDNVIQLLGYCALGSTRI 531 VF + G+ A+K+++ KQP +E ++ ++ + LK+ N++ L +G Sbjct: 261 GTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELF 320 Query: 532 LAYEYATRGSLHDVL 576 + EY GSL DV+ Sbjct: 321 VVMEYLAGGSLTDVV 335
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 49.3 bits (116), Expect = 8e-06 Identities = 35/135 (25%), Positives = 63/135 (46%), Gaps = 5/135 (3%) Frame = +1 Query: 187 PVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEI---TKNFSSDALIGEGSY 357 P+PAP G+ + G+ + + E L I I K ++ IG+G+ Sbjct: 201 PIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGAS 260 Query: 358 ARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLV-QVSAVSRLKHDNVIQLLGYCALGSTRI 531 VF + G+ A+K+++ KQP +E ++ ++ + LK+ N++ L +G Sbjct: 261 GTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELF 320 Query: 532 LAYEYATRGSLHDVL 576 + EY GSL DV+ Sbjct: 321 VVMEYLAGGSLTDVV 335
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 49.3 bits (116), Expect = 8e-06 Identities = 30/104 (28%), Positives = 56/104 (53%), Gaps = 11/104 (10%) Frame = +1 Query: 298 EIKEITKNFSSDAL------IGEGSYARVFLGVLKDGKNSAVKRLDS-----SKQPDQEF 444 E+K +T NF + +GEG + V+ G + + AVK+L + +++ Q+F Sbjct: 172 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNN-TTVAVKKLAAMVDITTEELKQQF 230 Query: 445 LVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++ +++ +H+N+++LLG+ + G L Y Y GSL D L Sbjct: 231 DQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRL 274
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +G G Y V+ GV K AVK L +EFL + + + +KH N++QLLG C Sbjct: 248 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR 307 Query: 517 GSTRILAYEYATRGSLHDVL 576 + E+ T G+L D L Sbjct: 308 EPPFYIITEFMTYGNLLDYL 327
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +G G Y V+ GV K AVK L +EFL + + + +KH N++QLLG C Sbjct: 248 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR 307 Query: 517 GSTRILAYEYATRGSLHDVL 576 + E+ T G+L D L Sbjct: 308 EPPFYIITEFMTYGNLLDYL 327
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +G G Y V+ GV K AVK L +EFL + + + +KH N++QLLG C Sbjct: 134 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR 193 Query: 517 GSTRILAYEYATRGSLHDVL 576 + E+ T G+L D L Sbjct: 194 EPPFYIITEFMTYGNLLDYL 213
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +G G Y V+ GV K AVK L +EFL + + + +KH N++QLLG C Sbjct: 197 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR 256 Query: 517 GSTRILAYEYATRGSLHDVL 576 + E+ T G+L D L Sbjct: 257 EPPFYIITEFMTYGNLLDYL 276
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 48.5 bits (114), Expect = 1e-05 Identities = 35/135 (25%), Positives = 63/135 (46%), Gaps = 5/135 (3%) Frame = +1 Query: 187 PVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEI---TKNFSSDALIGEGSY 357 P+PAP G+ + G+ + + E L I I K ++ IG+G+ Sbjct: 201 PIPAPVGDSHVDSGAKSSDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGAS 260 Query: 358 ARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLV-QVSAVSRLKHDNVIQLLGYCALGSTRI 531 VF + G+ A+K+++ KQP +E ++ ++ + LK+ N++ L +G Sbjct: 261 GTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELF 320 Query: 532 LAYEYATRGSLHDVL 576 + EY GSL DV+ Sbjct: 321 VVMEYLAGGSLTDVV 335
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 48.1 bits (113), Expect = 2e-05 Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 6/126 (4%) Frame = +1 Query: 217 YNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG-VLKDG- 390 +N G++ + + P P + ++IK +IGEG++ +V + KDG Sbjct: 797 FNSGTLALNRKAKNNPDPTIYPVLDWNDIK-------FQDVIGEGNFGQVLKARIKKDGL 849 Query: 391 -KNSAVKRLD--SSKQPDQEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRG 558 ++A+KR+ +SK ++F ++ + +L H N+I LLG C LA EYA G Sbjct: 850 RMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHG 909 Query: 559 SLHDVL 576 +L D L Sbjct: 910 NLLDFL 915
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 48.1 bits (113), Expect = 2e-05 Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 6/126 (4%) Frame = +1 Query: 217 YNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG-VLKDG- 390 +N G++ + + P P + ++IK +IGEG++ +V + KDG Sbjct: 794 FNSGTLALNRKAKNNPDPTIYPVLDWNDIK-------FQDVIGEGNFGQVLKARIKKDGL 846 Query: 391 -KNSAVKRLD--SSKQPDQEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRG 558 ++A+KR+ +SK ++F ++ + +L H N+I LLG C LA EYA G Sbjct: 847 RMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHG 906 Query: 559 SLHDVL 576 +L D L Sbjct: 907 NLLDFL 912
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 11/120 (9%) Frame = +1 Query: 250 RTSRSQPIEVPAIPLDEIKEITKNFSSDAL------IGEGSYARVFLGVLKDGKNSAVKR 411 R+ S + E+K IT NF +GEG + V+ G + + AVK+ Sbjct: 156 RSVESSDTRFHSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNN-TIVAVKK 214 Query: 412 LD-----SSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L S+++ Q+F ++ ++ +H+N+++LLG+ + L Y Y GSL D L Sbjct: 215 LGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRL 274
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 47.8 bits (112), Expect = 2e-05 Identities = 32/116 (27%), Positives = 63/116 (54%) Frame = +1 Query: 229 SVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVK 408 S + + +S + IE P+ L+ + K + ++G G++ V + K+ A+K Sbjct: 5 SAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWR-AKDVAIK 63 Query: 409 RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++S + + F+V++ +SR+ H N+++L G C + L EYA GSL++VL Sbjct: 64 QIESESER-KAFIVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVL 116
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 47.4 bits (111), Expect = 3e-05 Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 6/126 (4%) Frame = +1 Query: 217 YNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG-VLKDG- 390 +N G++ + + P P + ++IK +IGEG++ +V + KDG Sbjct: 796 FNSGTLALNRKVKNNPDPTIYPVLDWNDIK-------FQDVIGEGNFGQVLKARIKKDGL 848 Query: 391 -KNSAVKRLD--SSKQPDQEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRG 558 ++A+KR+ +SK ++F ++ + +L H N+I LLG C LA EYA G Sbjct: 849 RMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHG 908 Query: 559 SLHDVL 576 +L D L Sbjct: 909 NLLDFL 914
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 47.0 bits (110), Expect = 4e-05 Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 3/82 (3%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQ---EFLVQVSAVSRLKHDNVIQLLGYC 510 IG GSY VF G K G + AVK+ K + EF +++ +S LKH N++ +G C Sbjct: 1370 IGLGSYGIVFNGKWK-GVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGAC 1428 Query: 511 ALGSTRILAYEYATRGSLHDVL 576 + EY G+L DVL Sbjct: 1429 IKKPNICIVTEYMRMGNLRDVL 1450 Score = 42.0 bits (97), Expect = 0.001 Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 3/82 (3%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDS---SKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 +G G Y V+ + K G AVK + S SK ++ F +V ++ L+H NV+ + Sbjct: 792 LGTGGYGEVYKSIWK-GTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850 Query: 511 ALGSTRILAYEYATRGSLHDVL 576 + E+ + GSL+D+L Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLL 872
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 47.0 bits (110), Expect = 4e-05 Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 7/115 (6%) Frame = +1 Query: 253 TSRSQPIEVP-AIPLDEIKEITKNFSSDALIGEGSYARVFLGVLK-DG--KNSAVKRLD- 417 T R +P P + P+ E ++IT + LIGEG++ +V ++K DG N+A+K L Sbjct: 815 TRRPKPQPEPLSYPVLEWEDIT----FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE 870 Query: 418 -SSKQPDQEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +S+ ++F ++ + +L H N+I LLG C +A EYA G+L D L Sbjct: 871 YASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFL 925
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 46.6 bits (109), Expect = 5e-05 Identities = 34/110 (30%), Positives = 59/110 (53%), Gaps = 6/110 (5%) Frame = +1 Query: 265 QPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLK-DG--KNSAVKRLD--SSKQ 429 +P+ P + ++I + + LIGEG++ +V ++K DG N+A+K L +S+ Sbjct: 827 EPLSYPVLEWEDI-------TFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASEN 879 Query: 430 PDQEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++F ++ + +L H N+I LLG C +A EYA G+L D L Sbjct: 880 DHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFL 929
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 46.6 bits (109), Expect = 5e-05 Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G +A V+LG A+K L + FL + + +LKHD ++QL Y + Sbjct: 273 LGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL--YAVVS 330 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 331 EEPIYIVTEYMSKGSLLDFL 350
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 46.6 bits (109), Expect = 5e-05 Identities = 34/110 (30%), Positives = 59/110 (53%), Gaps = 6/110 (5%) Frame = +1 Query: 265 QPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLK-DG--KNSAVKRLD--SSKQ 429 +P+ P + ++I + + LIGEG++ +V ++K DG N+A+K L +S+ Sbjct: 825 EPLNYPVLEWEDI-------TFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASEN 877 Query: 430 PDQEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++F ++ + +L H N+I LLG C +A EYA G+L D L Sbjct: 878 DHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFL 927
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/138 (23%), Positives = 67/138 (48%), Gaps = 8/138 (5%) Frame = +1 Query: 187 PVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEIT------KNFSSDALIGE 348 PVPAP G+ + + ++ + +P +++++ I K ++ IG+ Sbjct: 201 PVPAPVGDSHVDGAA---KSLDKQKKKPKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQ 257 Query: 349 GSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLV-QVSAVSRLKHDNVIQLLGYCALGS 522 G+ VF + G+ A+K+++ KQP +E ++ ++ + LK+ N++ L +G Sbjct: 258 GASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGD 317 Query: 523 TRILAYEYATRGSLHDVL 576 + EY GSL DV+ Sbjct: 318 ELFVVMEYLAGGSLTDVV 335
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 46.2 bits (108), Expect = 7e-05 Identities = 26/85 (30%), Positives = 48/85 (56%), Gaps = 6/85 (7%) Frame = +1 Query: 340 IGEGSYARVFLG-VLKDGKNS---AVKRL--DSSKQPDQEFLVQVSAVSRLKHDNVIQLL 501 +GEG++ +V+ G +L+ K + A+K L ++S + Q+F ++ +S LKH N++ +L Sbjct: 416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCIL 475 Query: 502 GYCALGSTRILAYEYATRGSLHDVL 576 G + +EY G LH+ L Sbjct: 476 GVVLNKEPYCMLFEYMANGDLHEFL 500
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 45.8 bits (107), Expect = 9e-05 Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 2/108 (1%) Frame = +1 Query: 259 RSQPIEVPAIPLDEIKEITK-NFSSDALIGEGSYARVFLGVLKD-GKNSAVKRLDSSKQP 432 +++P P P + EI + + +G G Y V+ V K G AVK L Sbjct: 349 QNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMA 408 Query: 433 DQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++FL + + + +KH N++QL+G C + E+ + G+L D L Sbjct: 409 LKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFL 456
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 45.4 bits (106), Expect = 1e-04 Identities = 33/98 (33%), Positives = 49/98 (50%), Gaps = 3/98 (3%) Frame = +1 Query: 292 LDEIKEITKNFSSDAL---IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSA 462 LD ++ +FS L +G GSY V V +D + + S++Q D E +V Sbjct: 6 LDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIE--KEVKQ 63 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +SR+KH N+I L G + L E+A GSLH+ L Sbjct: 64 LSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFL 101
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 45.4 bits (106), Expect = 1e-04 Identities = 26/97 (26%), Positives = 46/97 (47%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 IP EI+ + K +G G++ VF G ++ + AVK L FL + + + Sbjct: 279 IPRSEIQLLRK-------LGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIM 331 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + +H+ ++ L C+ + EY ++GSL D L Sbjct: 332 KKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFL 368
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.4 bits (106), Expect = 1e-04 Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 1/83 (1%) Frame = +1 Query: 331 DALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 +A +G+G + V++G D A+K L + FL + + +L+H+ ++QL Y Sbjct: 269 EAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YA 326 Query: 511 ALGSTRI-LAYEYATRGSLHDVL 576 + I + EY ++GSL D L Sbjct: 327 VVSEEPIYIVIEYMSKGSLLDFL 349
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 45.1 bits (105), Expect = 1e-04 Identities = 21/79 (26%), Positives = 37/79 (46%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG G + V LG + A+K + +++F+ + + +L H ++QL G C Sbjct: 374 IGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQ 433 Query: 520 STRILAYEYATRGSLHDVL 576 + L +E+ G L D L Sbjct: 434 APICLVFEFMEHGCLSDYL 452
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 9/112 (8%) Frame = +1 Query: 256 SRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG----VLKDGKNS---AVKRL 414 S+++ +PA P D++ + L+G G++ V+ G +L DG AVK L Sbjct: 83 SQAEIESLPAFPRDKL-------NLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTL 135 Query: 415 D--SSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 ++ Q EFL + +S+ H ++++LLG C L + L E G L Sbjct: 136 KRGATDQEKSEFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDL 187
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 44.3 bits (103), Expect = 3e-04 Identities = 21/79 (26%), Positives = 37/79 (46%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG G + V LG + A+K + +++F+ + + +L H ++QL G C Sbjct: 369 IGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQ 428 Query: 520 STRILAYEYATRGSLHDVL 576 + L +E+ G L D L Sbjct: 429 APICLVFEFMEHGCLSDYL 447
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 44.3 bits (103), Expect = 3e-04 Identities = 39/129 (30%), Positives = 58/129 (44%), Gaps = 16/129 (12%) Frame = +1 Query: 238 THAIRTSRSQPIEVPAIPLDEIKEITKNFSSDAL-----IGEGSYARVFLGVL------- 381 T A+ + E+P P+ E FS D L +GEG + +V + Sbjct: 445 TDAMPLANVSEYELPHDPMWE-------FSRDKLTLGKPLGEGCFGQVVMAEALGIDKER 497 Query: 382 -KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRL--KHDNVIQLLGYCALGSTRILAYEYA 549 K+ AVK L D++ + D LV + ++ KH N+I LLG C G T + EYA Sbjct: 498 PKESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYA 557 Query: 550 TRGSLHDVL 576 +G+L L Sbjct: 558 AKGNLRQYL 566
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 9/112 (8%) Frame = +1 Query: 256 SRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG----VLKDGKNS---AVKRL 414 S+++ +PA P D++ + L+G G++ V+ G +L DG AVK L Sbjct: 1946 SQAEIESLPAFPRDKL-------NLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTL 1998 Query: 415 D--SSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 ++ Q EFL + +S+ H ++++LLG C L + L E G L Sbjct: 1999 KRGATDQEKSEFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDL 2050
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 44.3 bits (103), Expect = 3e-04 Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 6/120 (5%) Frame = +1 Query: 235 PTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG-VLKDG--KNSAV 405 P H S+ + PA+ +I+ ++GEG++ +V + KDG ++AV Sbjct: 794 PPHRRSAVVSRSLVFPALQWSDIQ-------FQDVLGEGNFGQVLKARIRKDGLRMDAAV 846 Query: 406 KRL-DSSKQPD-QEFLVQVSAVSRL-KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 KR+ D + Q D ++F ++ + RL H N+I LLG C LA E+A G+L D L Sbjct: 847 KRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFL 906
>FGFR2_DROME (Q09147) Fibroblast growth factor receptor homolog 2 precursor (EC| 2.7.10.1) (Protein breathless) (dFGF-R1) Length = 1052 Score = 43.9 bits (102), Expect = 3e-04 Identities = 37/120 (30%), Positives = 55/120 (45%), Gaps = 12/120 (10%) Frame = +1 Query: 253 TSRSQPIEVPAIPLDEIKEITKN-FSSDALIGEGSYARVFLGVLKDGKNS--------AV 405 T +Q PLD EI + S +++GEG++ RV + + S AV Sbjct: 688 TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAV 747 Query: 406 KRL-DSSKQPDQEFLVQVSAVSRL--KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 K + + D LV+ V ++ KH N+I LLG C+ G + EYA G+L D L Sbjct: 748 KMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFL 807
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 43.9 bits (102), Expect = 3e-04 Identities = 21/79 (26%), Positives = 40/79 (50%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V G + ++AVK + + +F+ + +++L+H N++QL G C+ Sbjct: 532 LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591 Query: 520 STRILAYEYATRGSLHDVL 576 + EY GSL + L Sbjct: 592 RPIYIVTEYMKHGSLLNYL 610
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 43.9 bits (102), Expect = 3e-04 Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V++G A+K L + FL + + +LKHD ++QL Y + Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL--YAVVS 333 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 334 EEPIYIVTEYMSKGSLLDFL 353
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 43.9 bits (102), Expect = 3e-04 Identities = 28/81 (34%), Positives = 45/81 (55%), Gaps = 1/81 (1%) Frame = +1 Query: 337 LIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +IG+G + V LG + G AVK + + Q FL + S +++L+H N++QLLG Sbjct: 200 IIGKGEFGDVMLGDYR-GNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVE 257 Query: 517 GSTRI-LAYEYATRGSLHDVL 576 + + + EY +GSL D L Sbjct: 258 EKSGLYIVTEYMAKGSLVDYL 278
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 43.9 bits (102), Expect = 3e-04 Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 5/98 (5%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRL-----DSSKQPDQEFLVQVSA 462 ++ + T +F+ + I +G++A V+ G + GK K+L S ++ F ++ Sbjct: 202 DVVQATDDFNQNRKISQGTFADVYRGH-RHGKPFVFKKLRETACSSPGSIERFFQAELQI 260 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 R H NV+ +LG+CA Y Y GSL D L Sbjct: 261 CLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRL 298
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL +D AVK L D+S ++F + ++ L+H+++++ Sbjct: 540 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 599 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 600 YGVCVEGDPLIMVFEYMKHGDLNKFL 625
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL +D AVK L D+S ++F + ++ L+H+++++ Sbjct: 543 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 602 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 603 YGVCVEGDPLIMVFEYMKHGDLNKFL 628
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL +D AVK L D+S ++F + ++ L+H+++++ Sbjct: 543 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 602 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 603 YGVCVEGDPLIMVFEYMKHGDLNKFL 628
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 12/109 (11%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDAL------------IGEGSYARVFLGVLKDGKNSAVKRLDSSKQ 429 +P + K +T + DA +G G + V+ GV + AVK L Sbjct: 216 LPCPKDKPVTGGIAKDAWEIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTM 275 Query: 430 PDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 FL + + +L+H +++QL C+ + EY + GSL D L Sbjct: 276 SPASFLDEAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYL 324
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL +D AVK L D+S ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCVEGDPLIMVFEYMKHGDLNKFL 629
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 43.5 bits (101), Expect = 4e-04 Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V++G A+K L + FL + + +LKHD ++QL Y + Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL--YAVVS 333 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY +GSL D L Sbjct: 334 EEPIYIVTEYMNKGSLLDFL 353
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/106 (26%), Positives = 50/106 (47%) Frame = +1 Query: 259 RSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQ 438 + Q ++ +P +EI ++ +G G+ VFLG G+ AVK++ K+ D Sbjct: 111 KQQQEDLWEVPFEEILDLQ-------WVGSGAQGAVFLGRFH-GEEVAVKKVRDLKETD- 161 Query: 439 EFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + + +LKH N+I G C + E+ +G L++VL Sbjct: 162 -----IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL 202
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/106 (26%), Positives = 50/106 (47%) Frame = +1 Query: 259 RSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQ 438 + Q ++ +P +EI ++ +G G+ VFLG G+ AVK++ K+ D Sbjct: 144 KQQQEDLWEVPFEEILDLQ-------WVGSGAQGAVFLGRFH-GEEVAVKKVRDLKETD- 194 Query: 439 EFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + + +LKH N+I G C + E+ +G L++VL Sbjct: 195 -----IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL 235
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/106 (26%), Positives = 50/106 (47%) Frame = +1 Query: 259 RSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQ 438 + Q ++ +P +EI ++ +G G+ VFLG G+ AVK++ K+ D Sbjct: 144 KQQQEDLWEVPFEEILDLQ-------WVGSGAQGAVFLGRFH-GEEVAVKKVRDLKETD- 194 Query: 439 EFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + + +LKH N+I G C + E+ +G L++VL Sbjct: 195 -----IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL 235
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 43.1 bits (100), Expect = 6e-04 Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 5/135 (3%) Frame = +1 Query: 187 PVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARV 366 P P N + VP H + ++ I I E TK+F D LIGEG V Sbjct: 137 PGPLEPANVTVDNVLVPEH----NEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEV 192 Query: 367 FLGVLKDGKNSAVKRLDSSKQPD-----QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRI 531 + +++ + AVK K+ + FL ++ + +H ++++L Y Sbjct: 193 YRVDIRN-QAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLC 251 Query: 532 LAYEYATRGSLHDVL 576 L Y Y + G+L D L Sbjct: 252 LVYPYMSNGTLFDRL 266
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 43.1 bits (100), Expect = 6e-04 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL KD AVK L D + ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 43.1 bits (100), Expect = 6e-04 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL KD AVK L D + ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 43.1 bits (100), Expect = 6e-04 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL KD AVK L D + ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 43.1 bits (100), Expect = 6e-04 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL KD AVK L D + ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 43.1 bits (100), Expect = 6e-04 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL +D AVK L ++S+ Q+F + ++ L+H ++++ Sbjct: 516 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 575 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G ++ +EY G L+ L Sbjct: 576 FGVCTEGRPLLMVFEYMRHGDLNRFL 601
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 43.1 bits (100), Expect = 6e-04 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL KD AVK L D + ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL 629
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 43.1 bits (100), Expect = 6e-04 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNS------AVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL + N AVK L ++S+ Q+F + ++ L+H ++++ Sbjct: 519 LGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRF 578 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G ++ +EY G L+ L Sbjct: 579 FGVCTEGGPLLMVFEYMRHGDLNRFL 604
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 43.1 bits (100), Expect = 6e-04 Identities = 26/97 (26%), Positives = 44/97 (45%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 +P +EI E+ +G G+ VFLG + + A+K++ + D + + Sbjct: 163 VPFEEISELQ-------WLGSGAQGAVFLGKFR-AEEVAIKKVREQNETD------IKHL 208 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +LKH N+I G C + EY G L++VL Sbjct: 209 RKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 245
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 43.1 bits (100), Expect = 6e-04 Identities = 26/97 (26%), Positives = 44/97 (45%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 +P +EI E+ +G G+ VFLG + + A+K++ + D + + Sbjct: 163 VPFEEISELQ-------WLGSGAQGAVFLGKFR-AEEVAIKKVREQNETD------IKHL 208 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +LKH N+I G C + EY G L++VL Sbjct: 209 RKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 245
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL----GVL--KDGKNSAVKRLDSSKQPDQE--FLVQVSAVSRLKHDNVIQ 495 IGEG++ RVF G+L + AVK L D + F + + ++ + N+++ Sbjct: 581 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 640 Query: 496 LLGYCALGSTRILAYEYATRGSLHDVL 576 LLG CA+G L +EY G L++ L Sbjct: 641 LLGVCAVGKPMCLLFEYMAYGDLNEFL 667
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 42.7 bits (99), Expect = 7e-04 Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 1/83 (1%) Frame = +1 Query: 331 DALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 +A +G+G + V++G A+K L + FL + + +L+H+ ++QL Y Sbjct: 269 EAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YA 326 Query: 511 ALGSTRI-LAYEYATRGSLHDVL 576 + I + EY ++GSL D L Sbjct: 327 VVSEEPIYIVIEYMSKGSLLDFL 349
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL----GVL--KDGKNSAVKRLDSSKQPDQE--FLVQVSAVSRLKHDNVIQ 495 IGEG++ RVF G+L + AVK L D + F + + ++ + N+++ Sbjct: 661 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 720 Query: 496 LLGYCALGSTRILAYEYATRGSLHDVL 576 LLG CA+G L +EY G L++ L Sbjct: 721 LLGVCAVGKPMCLLFEYMAYGDLNEYL 747
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL----GVL--KDGKNSAVKRLDSSKQPDQE--FLVQVSAVSRLKHDNVIQ 495 IGEG++ RVF G+L + AVK L D + F + + ++ + N+++ Sbjct: 580 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 639 Query: 496 LLGYCALGSTRILAYEYATRGSLHDVL 576 LLG CA+G L +EY G L++ L Sbjct: 640 LLGVCAVGKPMCLLFEYMAYGDLNEFL 666
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL----GVL--KDGKNSAVKRLDSSKQPDQE--FLVQVSAVSRLKHDNVIQ 495 IGEG++ RVF G+L + AVK L D + F + + ++ + N+++ Sbjct: 580 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 639 Query: 496 LLGYCALGSTRILAYEYATRGSLHDVL 576 LLG CA+G L +EY G L++ L Sbjct: 640 LLGVCAVGKPMCLLFEYMAYGDLNEFL 666
>RTK2_GEOCY (P42159) Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK)| Length = 605 Score = 42.7 bits (99), Expect = 7e-04 Identities = 35/138 (25%), Positives = 55/138 (39%), Gaps = 21/138 (15%) Frame = +1 Query: 226 GSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNS-- 399 G + I+ QP+ V + E+K+I G G + V L + S Sbjct: 324 GPIYARPIKQKMRQPLNVSVDNIREVKQI----------GVGQFGAVVLAEMTGLSGSER 373 Query: 400 -----------------AVKRL--DSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGS 522 AVK+L D S++ Q F ++ VS+L+HD+++QLL C Sbjct: 374 CVPTKRDPSMLNGVALVAVKKLKPDVSEEVRQSFDKEIKFVSQLQHDSIVQLLAVCTHSK 433 Query: 523 TRILAYEYATRGSLHDVL 576 + EY G L+ L Sbjct: 434 HPFIVMEYMENGDLNQFL 451
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/97 (26%), Positives = 43/97 (44%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 IP + IK + K +G G + V++G + AVK L Q FL + + + Sbjct: 241 IPRESIKLVKK-------LGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSAQAFLEEANLM 293 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L+HD +++L + E+ +GSL D L Sbjct: 294 KTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFL 330
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/97 (26%), Positives = 43/97 (44%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 IP + IK + + +G G + V++G + AVK L Q FL + + + Sbjct: 241 IPRESIKLVKR-------LGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM 293 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L+HD +++L + EY +GSL D L Sbjct: 294 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFL 330
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/97 (26%), Positives = 43/97 (44%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 IP + IK + K +G G + V++G + AVK L Q FL + + + Sbjct: 241 IPRESIKLVKK-------LGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM 293 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L+HD +++L + E+ +GSL D L Sbjct: 294 KTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFL 330
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 42.4 bits (98), Expect = 0.001 Identities = 35/113 (30%), Positives = 52/113 (46%), Gaps = 11/113 (9%) Frame = +1 Query: 271 IEVPAIPLDEIKEITKNFSSDALIGEGSYARVFL----GVLKDGKNS----AVKRL-DSS 423 +E+PA P E+ +GEG + +V + G+ KD AVK L D + Sbjct: 451 LELPADPKWELSRTRLTLGKP--LGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDA 508 Query: 424 KQPDQEFLVQVSAVSRL--KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 D LV + ++ KH N+I LLG C G + EYA +G+L + L Sbjct: 509 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 561
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 42.4 bits (98), Expect = 0.001 Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 2/98 (2%) Frame = +1 Query: 277 VPAIPL--DEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLV 450 +P IPL DE + F +GEG + V+ G+ AVK + S+ + Sbjct: 217 IPQIPLVQDEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTK 276 Query: 451 QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 ++ A+ L+H+ +I+L C+LG + E +G+L Sbjct: 277 EIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNL 314
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 42.4 bits (98), Expect = 0.001 Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 19/144 (13%) Frame = +1 Query: 202 GGNYGYNRGSVPT------------HAIRTSRSQPIEVPAIPL-------DEIKEITKNF 324 GG Y NR S PT + S+P IP+ DE + Sbjct: 7 GGFYMANRISFPTLQNLVSHYMMDADGLAQRLSRPCSRANIPITSGLSYKDEWEIDRTTI 66 Query: 325 SSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLG 504 +G+G++ V+ GV AVK L ++F+ + + ++ H N++QL Sbjct: 67 QLQRKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTMEVKDFVQEAQVMKKIHHPNLLQLYA 126 Query: 505 YCALGSTRILAYEYATRGSLHDVL 576 C +G + E GS+ + L Sbjct: 127 VCTIGEPIYIVTELMKYGSMLEYL 150
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (CD333 antigen) Length = 806 Score = 42.4 bits (98), Expect = 0.001 Identities = 35/113 (30%), Positives = 52/113 (46%), Gaps = 11/113 (9%) Frame = +1 Query: 271 IEVPAIPLDEIKEITKNFSSDALIGEGSYARVFL----GVLKDGKNS----AVKRL-DSS 423 +E+PA P E+ +GEG + +V + G+ KD AVK L D + Sbjct: 457 LELPADPKWELSRARLTLGKP--LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 514 Query: 424 KQPDQEFLVQVSAVSRL--KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 D LV + ++ KH N+I LLG C G + EYA +G+L + L Sbjct: 515 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 42.4 bits (98), Expect = 0.001 Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V++G AVK L + FL + + +L+HD ++QL Y + Sbjct: 276 LGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQL--YAVVS 333 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 334 EEPIYIVTEYMSKGSLLDFL 353
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/94 (27%), Positives = 50/94 (53%), Gaps = 3/94 (3%) Frame = +1 Query: 238 THAIRTSRSQPIEVPAIPLDEIKEIT-KNFSSDALIGEGSYARVFLGVLKDGKNSAVK-- 408 T + T +S + + IP D+ + ++ S L+G+G++ V+ G LKD AVK Sbjct: 35 TKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTC 94 Query: 409 RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 + D ++ +FL + + + H N+++L+G C Sbjct: 95 KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVC 128
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 42.0 bits (97), Expect = 0.001 Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRL-------DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL + + VK L D + ++F + ++ L+H+++++ Sbjct: 544 LGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL 629
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/80 (35%), Positives = 43/80 (53%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG+G + V LG + G AVK + + Q FL + S +++L+H N++QLLG Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEE 258 Query: 520 STRI-LAYEYATRGSLHDVL 576 + + EY +GSL D L Sbjct: 259 KGGLYIVTEYMAKGSLVDYL 278
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/80 (35%), Positives = 43/80 (53%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG+G + V LG + G AVK + + Q FL + S +++L+H N++QLLG Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEE 258 Query: 520 STRI-LAYEYATRGSLHDVL 576 + + EY +GSL D L Sbjct: 259 KGGLYIVTEYMAKGSLVDYL 278
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/80 (35%), Positives = 43/80 (53%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG+G + V LG + G AVK + + Q FL + S +++L+H N++QLLG Sbjct: 201 IGKGEFGDVMLGDYR-GNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEE 258 Query: 520 STRI-LAYEYATRGSLHDVL 576 + + EY +GSL D L Sbjct: 259 KGGLYIVTEYMAKGSLVDYL 278
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 42.0 bits (97), Expect = 0.001 Identities = 35/128 (27%), Positives = 56/128 (43%), Gaps = 2/128 (1%) Frame = +1 Query: 199 PGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGV 378 P ++G + P+ +++ P D +E NF IGEGS V + Sbjct: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDP-REYLDNFIK---IGEGSTGIVCIAT 467 Query: 379 LKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSR-LKHDNVIQLLGYCALGSTRILAYEYAT 552 K GK AVK++D KQ +E L + R HDNV+ + +G + E+ Sbjct: 468 EKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLE 527 Query: 553 RGSLHDVL 576 G+L D++ Sbjct: 528 GGALTDIV 535
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 42.0 bits (97), Expect = 0.001 Identities = 35/128 (27%), Positives = 56/128 (43%), Gaps = 2/128 (1%) Frame = +1 Query: 199 PGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGV 378 P ++G + P+ +++ P D +E NF IGEGS V + Sbjct: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDP-REYLANFIK---IGEGSTGIVCIAT 467 Query: 379 LKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSR-LKHDNVIQLLGYCALGSTRILAYEYAT 552 K GK AVK++D KQ +E L + R HDNV+ + +G + E+ Sbjct: 468 EKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLE 527 Query: 553 RGSLHDVL 576 G+L D++ Sbjct: 528 GGALTDIV 535
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/125 (23%), Positives = 60/125 (48%), Gaps = 5/125 (4%) Frame = +1 Query: 217 YNRGSVPTHAIRTS----RSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLK 384 Y+R +H +R + + +P +P D+ + + F+ +G G + VF G+ K Sbjct: 154 YHRAQSLSHGLRLAAPCRKHEPEPLPH--WDDWERPREEFTLCRKLGSGYFGEVFEGLWK 211 Query: 385 DGKNSAVKRLDSSKQPDQEFLV-QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGS 561 D A+K + Q+ L ++ A+ +L+H +++ L ++G + E +GS Sbjct: 212 DRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGS 271 Query: 562 LHDVL 576 L ++L Sbjct: 272 LLELL 276
>LET23_CAEEL (P24348) Receptor tyrosine-protein kinase let-23 precursor (EC| 2.7.10.1) (Lethal protein 23) Length = 1367 Score = 41.6 bits (96), Expect = 0.002 Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 6/88 (6%) Frame = +1 Query: 331 DALIGEGSYARVFLGVL--KDGKNS----AVKRLDSSKQPDQEFLVQVSAVSRLKHDNVI 492 D +G G++ VF G+ K KN A+K + + E L + + + RL+HDN++ Sbjct: 932 DKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLL 991 Query: 493 QLLGYCALGSTRILAYEYATRGSLHDVL 576 +++G+C + Y G+L + L Sbjct: 992 KIIGFCMHDDGLKIVTIYRPLGNLQNFL 1019
>KIN31_CAEEL (P34265) Probable tyrosine-protein kinase kin-31 (EC 2.7.10.2)| Length = 437 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/94 (28%), Positives = 45/94 (47%), Gaps = 8/94 (8%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGVLKDGKNS-----AVKRLDSS---KQPDQEFLVQVSAVSRL 474 N + +GEG++ V GV+K + AVK++ + K ++FL++ + L Sbjct: 129 NIVIEKKLGEGAFGEVSSGVMKFKRGGRLVKVAVKQVKTDGIGKDQIKDFLMEARTMRNL 188 Query: 475 KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 H N+++ LG L L E AT G+L L Sbjct: 189 GHPNIVRFLGIAVLQEPLFLVMELATGGALDSYL 222
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 41.6 bits (96), Expect = 0.002 Identities = 44/155 (28%), Positives = 64/155 (41%), Gaps = 15/155 (9%) Frame = +1 Query: 157 KKKKRDDPY-------VPVPAPGGNYGYNRGSV--PTHAIRTSRSQPIEVPAIPLDEIKE 309 K K+R+ PY + G Y + + P AIR + I+V I ++E+ Sbjct: 586 KSKRRETPYTDRLQQYISTRGLGVKYYIDPSTYEDPNEAIREFAKE-IDVSFIKIEEV-- 642 Query: 310 ITKNFSSDALIGEGSYARVFLGVLKD-GKNS---AVKRLDSSKQPDQ--EFLVQVSAVSR 471 IG G + V G LK GK A+K L S +Q EFL + S + + Sbjct: 643 ----------IGSGEFGEVCFGRLKHPGKREYTVAIKTLKSGYTDEQRREFLSEASIMGQ 692 Query: 472 LKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +H NVI L G ++ E+ GSL L Sbjct: 693 FEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFL 727
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 41.6 bits (96), Expect = 0.002 Identities = 23/76 (30%), Positives = 38/76 (50%), Gaps = 1/76 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G +A V+ G A+K L + FL + + +LKHD ++QL Y + Sbjct: 273 LGQGCFAEVWRGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL--YAVVS 330 Query: 520 STRI-LAYEYATRGSL 564 I + EY ++GSL Sbjct: 331 RRPIYIVTEYMSKGSL 346
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 41.6 bits (96), Expect = 0.002 Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 7/87 (8%) Frame = +1 Query: 337 LIGEGSYARVFLGVLKDGKNSAVKR--LDSSKQPDQE-----FLVQVSAVSRLKHDNVIQ 495 ++G+G+Y V+ G+ G+ AVK+ LD+S + E +V + LKH N++ Sbjct: 1066 ILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 1125 Query: 496 LLGYCALGSTRILAYEYATRGSLHDVL 576 LG C +T + E+ GS+ ++ Sbjct: 1126 YLGTCLQENTVSIFMEFVPGGSISSII 1152
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/101 (25%), Positives = 45/101 (44%), Gaps = 2/101 (1%) Frame = +1 Query: 280 PAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVS 459 P + +I+ +N IG G + V A K L SSK ++F+++ Sbjct: 206 PPVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREKFVLEAK 265 Query: 460 AVSRLKHDNVIQLLGYCA--LGSTRILAYEYATRGSLHDVL 576 + +L+H +++LLG C ++ EY GSL + L Sbjct: 266 IMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYL 306
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 41.2 bits (95), Expect = 0.002 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNS-AVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCAL 516 +G G Y V+ G K + AVK L P EFL + + + L H N+++LLG C Sbjct: 317 LGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTH 376 Query: 517 GSTRILAYEYATRGSLHDVL 576 + + E+ G+L + L Sbjct: 377 EAPFYIITEFMCNGNLLEYL 396
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 41.2 bits (95), Expect = 0.002 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 19/98 (19%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNS-----------------AVK--RLDSSKQPDQEFLVQVSA 462 +GEG + V L ++D ++ AVK R D++K +FL +V Sbjct: 614 LGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKI 673 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +SRLK N+I+LLG C + +Y G L+ L Sbjct: 674 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL 711
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 41.2 bits (95), Expect = 0.002 Identities = 20/79 (25%), Positives = 36/79 (45%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG G + V LG + A+K ++ +++F+ + + +L H ++QL G C Sbjct: 277 IGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQ 336 Query: 520 STRILAYEYATRGSLHDVL 576 + E+ G L D L Sbjct: 337 KPLYIVTEFMENGCLLDYL 355
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 41.2 bits (95), Expect = 0.002 Identities = 24/86 (27%), Positives = 43/86 (50%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLGVL------KDGKNSAVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL D AVK L D + ++F + ++ L+H+++++ Sbjct: 546 LGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 605 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 606 YGVCGDGDPLIMVFEYMKHGDLNKFL 631
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 41.2 bits (95), Expect = 0.002 Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 6/85 (7%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD--GK--NSAVKRLDSSK--QPDQEFLVQVSAVSRLKHDNVIQLL 501 +G G + V G+ GK N A+K L K Q ++EFL + +S+L H ++ LL Sbjct: 490 LGVGEFGSVIKGIWLSPGGKEINVAMKTLHKDKMVQGEKEFLREALVMSQLNHPCIVSLL 549 Query: 502 GYCALGSTRILAYEYATRGSLHDVL 576 G C LG IL E G+L D L Sbjct: 550 GVC-LGPPMILVQELVEMGALLDYL 573
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 41.2 bits (95), Expect = 0.002 Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V++G AVK L + FL + + RL+HD ++QL Y + Sbjct: 275 LGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPEAFLEEAQIMKRLRHDKLVQL--YAVVS 332 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + E+ ++GSL D L Sbjct: 333 EEPIYIVTEFMSQGSLLDFL 352
>EGL15_CAEEL (Q10656) Myoblast growth factor receptor egl-15 precursor (EC| 2.7.10.1) (Egg-laying defective protein 15) Length = 1040 Score = 41.2 bits (95), Expect = 0.002 Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 8/109 (7%) Frame = +1 Query: 274 EVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNS----AVKRLDSSKQPDQE 441 EV + P+ E++ S ++GEG++ V+ K+ +N+ AVK+L S ++E Sbjct: 626 EVDSDPVWEVER--SKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAH-EKE 682 Query: 442 FLVQVSAVSRLK----HDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + VS + K H+NV++L+G C + E G+L D L Sbjct: 683 LIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFL 731
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 275 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 332 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 333 EEPIYIVTEYMSKGSLLDFL 352
>PAK4_MOUSE (Q8BTW9) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 593 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 2/81 (2%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQVSAVSR-LKHDNVIQLLGYCA 513 IGEGS V + ++ GK AVK++D KQ +E L + R +H+NV+++ Sbjct: 329 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYL 388 Query: 514 LGSTRILAYEYATRGSLHDVL 576 +G + E+ G+L D++ Sbjct: 389 VGDELWVVMEFLEGGALTDIV 409
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 40.8 bits (94), Expect = 0.003 Identities = 24/79 (30%), Positives = 36/79 (45%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V+ G+ + AVK L +EFL + S + RL+H +IQL C Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCTKE 305 Query: 520 STRILAYEYATRGSLHDVL 576 + E GSL + L Sbjct: 306 EPIYIVTELMKYGSLLEYL 324
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 271 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 328 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 329 EEPIYIVTEYMSKGSLLDFL 348
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 271 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 328 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 329 EEPIYIVTEYISKGSLLDFL 348
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 40.8 bits (94), Expect = 0.003 Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 10/138 (7%) Frame = +1 Query: 193 PAPGGNYGYNRGSVPTHAIRTSRSQ-PIEVPAIPLDEIKEIT-KNFSSDALIGEGSYARV 366 PA G Y+ ++ ++ +Q P++ IP D E KN +GEG + +V Sbjct: 680 PAQGFPISYSSSGTRRPSLDSTENQVPVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKV 739 Query: 367 FLGVLKDGKNSA------VKRL--DSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGS 522 K A VK L ++S+ ++ L + + + ++ H +VI+L G C+ Sbjct: 740 VKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDG 799 Query: 523 TRILAYEYATRGSLHDVL 576 +L EYA GSL L Sbjct: 800 PLLLIVEYAKYGSLRGFL 817
>INSR_DROME (P09208) Insulin-like receptor precursor (EC 2.7.10.1) (DIR) (DInr)| (dIRH) [Contains: Insulin-like receptor alpha subunit; Insulin-like receptor beta 1 subunit; Insulin-like receptor beta 2 subunit] Length = 2144 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/102 (25%), Positives = 48/102 (47%), Gaps = 8/102 (7%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQ--------EFLV 450 D+ + + +N A +G+GS+ V+ G+LK + V R + K ++ FL Sbjct: 1362 DDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLS 1421 Query: 451 QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + S + +V++LLG C+ G ++ E +G L L Sbjct: 1422 EASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYL 1463
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 40.8 bits (94), Expect = 0.003 Identities = 19/79 (24%), Positives = 36/79 (45%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 IG G + V LG + A+K ++ +++F+ + + +L H ++QL G C Sbjct: 277 IGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQR 336 Query: 520 STRILAYEYATRGSLHDVL 576 + E+ G L + L Sbjct: 337 KPLYIVTEFMENGCLLNYL 355
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 40.8 bits (94), Expect = 0.003 Identities = 20/58 (34%), Positives = 31/58 (53%) Frame = +1 Query: 403 VKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + R D++K +FL +V +SRLK N+I+LLG C + +Y G L+ L Sbjct: 656 ILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL 713
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVTEYMSKGSLLDFL 349
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 3/80 (3%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNS-AVKRLDSSKQPD--QEFLVQVSAVSRLKHDNVIQLLGYC 510 +GEG+Y V L V + + + AVK +D + D + ++ L H+NV++ G+ Sbjct: 15 LGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAADCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 511 ALGSTRILAYEYATRGSLHD 570 G+T+ L EY + G L D Sbjct: 75 REGATQYLFLEYCSGGELFD 94
>ROR2_MOUSE (Q9Z138) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2) Length = 944 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/124 (28%), Positives = 58/124 (46%), Gaps = 14/124 (11%) Frame = +1 Query: 247 IRTSRSQPIEVPAIP------LDEIKEITKNFSSDALIGEGSYARVFLGVL------KDG 390 + S SQ +E+P I L EI T F + +GE + +V+ G L + Sbjct: 444 LMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEE--LGEDRFGKVYKGHLFGPAPGEPT 501 Query: 391 KNSAVKRL-DSSKQP-DQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 + A+K L D ++ P +EF + +RL+H N++ LLG + + Y + G L Sbjct: 502 QAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDL 561 Query: 565 HDVL 576 H+ L Sbjct: 562 HEFL 565
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVTEYMSKGSLLDFL 349
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVTEYMSKGSLLDFL 349
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 40.8 bits (94), Expect = 0.003 Identities = 29/106 (27%), Positives = 48/106 (45%), Gaps = 3/106 (2%) Frame = +1 Query: 268 PIEVPAIPLDEIKEITKN-FSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEF 444 P PLD E+ ++ A +GEG++ RV + + + + + D Sbjct: 397 PFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIAS 456 Query: 445 LVQVSAVSRL--KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 LV+ V ++ +H N+I LLG C+ + EYA G+L D L Sbjct: 457 LVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL 502
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/94 (26%), Positives = 51/94 (54%), Gaps = 3/94 (3%) Frame = +1 Query: 238 THAIRTSRSQPIEVPAIPLDEIKEIT-KNFSSDALIGEGSYARVFLGVLKDGKNSAVK-- 408 T + T +S + + IP D+ ++ ++ L+G+G++ V+ G LKD + AVK Sbjct: 534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTC 593 Query: 409 RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 + D ++ +FL + + + H N+++L+G C Sbjct: 594 KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVC 627
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 40.8 bits (94), Expect = 0.003 Identities = 20/58 (34%), Positives = 31/58 (53%) Frame = +1 Query: 403 VKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + R D++K +FL +V +SRLK N+I+LLG C + +Y G L+ L Sbjct: 652 ILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL 709
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 40.8 bits (94), Expect = 0.003 Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNSA----VKRL-DSSKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V + G+ KD N A VK L D + D LV + ++ KH N Sbjct: 472 LGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 531 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 532 IINLLGACTQDGPLYVLVEYASKGNLREYL 561
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVTEYMSKGSLLDFL 349
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVTEYMSKGSLLDFL 349
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 40.4 bits (93), Expect = 0.004 Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 10/137 (7%) Frame = +1 Query: 196 APGGNYGYNRGSVPTHAIRTSRSQPIE--VPAIP--LDEIKEIT-KNFSSDALIGEGSYA 360 A G+ G+ G +P+ + S + PA P L +EI + +IG G + Sbjct: 51 AVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFG 110 Query: 361 RVFLGVLKDGKNSAVK--RLDSSKQPD---QEFLVQVSAVSRLKHDNVIQLLGYCALGST 525 +V+ + + G+ AVK RLD K P ++ + L+H N+I L G C Sbjct: 111 KVYRALWR-GEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPH 169 Query: 526 RILAYEYATRGSLHDVL 576 L EYA G+L VL Sbjct: 170 LCLVMEYARGGALSRVL 186
>ATG1_ASHGO (Q75CH3) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 972 Score = 40.4 bits (93), Expect = 0.004 Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 6/91 (6%) Frame = +1 Query: 310 ITKNFSSDALIGEGSYARVFLGVLKDGK--NSAVKRLDSSKQPDQEFL----VQVSAVSR 471 + + + + IG GS+A V+ G L D N A+K + SK +++ L ++++ + + Sbjct: 14 VAERYVVEKEIGRGSFAVVYKGHLADSSAGNVAIKAVSRSKLRNKKLLENLEIEIAILKK 73 Query: 472 LKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 +KH +++ LL G+ L EY G L Sbjct: 74 IKHPHIVGLLECERTGTDFYLMMEYCALGDL 104
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/89 (29%), Positives = 45/89 (50%), Gaps = 4/89 (4%) Frame = +1 Query: 322 FSSDALIGEGSYARVFLGVLKDGKNS--AVKRLDSSKQPDQEFLV--QVSAVSRLKHDNV 489 FS LIG G++A VF G ++ + AVK ++ + L+ ++ + LKH+N+ Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L + + ++ L EY G L D L Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYL 104
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 40.4 bits (93), Expect = 0.004 Identities = 30/103 (29%), Positives = 45/103 (43%), Gaps = 5/103 (4%) Frame = +1 Query: 283 AIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPD-----QEFL 447 +I I E T+NF D LIGEG V+ +++ AVK K+ + FL Sbjct: 152 SISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQN-LTYAVKLFKQEKKMQCKKHWKRFL 210 Query: 448 VQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++ + H N+++L Y L Y Y G+L D L Sbjct: 211 SELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRL 253
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 40.4 bits (93), Expect = 0.004 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 269 LGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAMVS 326 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 327 EEPIYIVIEYMSKGSLLDFL 346
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 40.4 bits (93), Expect = 0.004 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 275 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 332 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY +GSL D L Sbjct: 333 EEPIYIVTEYMNKGSLLDFL 352
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 40.4 bits (93), Expect = 0.004 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ ++QL Y + Sbjct: 280 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVS 337 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY +GSL D L Sbjct: 338 EEPIYIVTEYMNKGSLLDFL 357
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/89 (29%), Positives = 45/89 (50%), Gaps = 4/89 (4%) Frame = +1 Query: 322 FSSDALIGEGSYARVFLGVLKDGKNS--AVKRLDSSKQPDQEFLV--QVSAVSRLKHDNV 489 FS LIG G++A VF G ++ + AVK ++ + L+ ++ + LKH+N+ Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L + + ++ L EY G L D L Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYL 104
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 40.4 bits (93), Expect = 0.004 Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 5/109 (4%) Frame = +1 Query: 265 QPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQE- 441 QP E+ LD IKE+ IG G + +V G DG+ A+K + + D + Sbjct: 133 QPHEIEYNELD-IKEV---------IGSGGFCKVHRGYY-DGEEVAIKIAHQTGEDDMQR 181 Query: 442 ----FLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L + LKH+N+ L G C L + L EYA GSL+ +L Sbjct: 182 MRDNVLQEAKLFWALKHENIAALRGVC-LNTKLCLVMEYARGGSLNRIL 229
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/79 (26%), Positives = 37/79 (46%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V+ G+ + A+K L S ++FL + + +L+H +IQL C + Sbjct: 254 LGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVE 313 Query: 520 STRILAYEYATRGSLHDVL 576 + E GSL + L Sbjct: 314 EPIYIITELMKHGSLLEYL 332
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 40.0 bits (92), Expect = 0.005 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 19/98 (19%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNS-----------------AVK--RLDSSKQPDQEFLVQVSA 462 +GEG + V L ++D ++ AVK R D++K +FL +V Sbjct: 613 LGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKI 672 Query: 463 VSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +SRLK N+I+LLG C + +Y G L+ L Sbjct: 673 MSRLKDLNIIRLLGVCVQDDPLCMITDYMENGDLNQFL 710
>IKKE_MOUSE (Q9R0T8) Inhibitor of nuclear factor kappa-B kinase epsilon subunit| (EC 2.7.11.1) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK-E) (Inducible I kappa-B kinase) (IKK-i) Length = 717 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/88 (31%), Positives = 48/88 (54%), Gaps = 5/88 (5%) Frame = +1 Query: 328 SDALIGEGSYARVFLGV-LKDGKNSAVKRLDSS--KQPDQEFLVQVSAVSRLKHDNVIQL 498 +D L+G+G+ A V+ K G+ AVK +S+ ++P + + + + RL H N+++L Sbjct: 11 TDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLNHQNIVKL 70 Query: 499 LGYCALGSTR--ILAYEYATRGSLHDVL 576 G +R +L EY + GSL VL Sbjct: 71 FAVEETGGSRQKVLIMEYCSSGSLLSVL 98
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 40.0 bits (92), Expect = 0.005 Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Frame = +1 Query: 331 DALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 D +G+G + V++G A+K L + FL + + +L+HD ++ L Y Sbjct: 273 DVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPL--YA 330 Query: 511 ALGSTRI-LAYEYATRGSLHDVL 576 + I + EY +GSL D L Sbjct: 331 VVSEEPIYIVTEYMIKGSLLDFL 353
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 40.0 bits (92), Expect = 0.005 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H ++QL Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHKKLVQL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVIEYMSKGSLLDFL 349
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 40.0 bits (92), Expect = 0.005 Identities = 22/79 (27%), Positives = 34/79 (43%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V+ G+ + AVK L +FL + + L+H +IQL C L Sbjct: 240 LGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLE 299 Query: 520 STRILAYEYATRGSLHDVL 576 + E GSL + L Sbjct: 300 DPIYIITELMRHGSLQEYL 318
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 40.0 bits (92), Expect = 0.005 Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 17/131 (12%) Frame = +1 Query: 235 PTHAIRTSRSQPIEVPAIPLDEIKEIT-----KNFSSDAL-----IGEGSYARVFLGVLK 384 PT+ +T SQ + D +T +N+S D +G+G + +V+L +K Sbjct: 60 PTNLTKTPASQVSRRSSYTTDPPSPLTGITGFRNYSLDDFEIGKALGKGKFGKVYL--VK 117 Query: 385 DGKNSAVKRLDSSKQPD-------QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYE 543 D K V L ++ + ++F +V S L+H NV++L G+ L E Sbjct: 118 DKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTNVLRLFGHFHDKDRVYLILE 177 Query: 544 YATRGSLHDVL 576 Y G L+ +L Sbjct: 178 YVVHGELYKLL 188
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 40.0 bits (92), Expect = 0.005 Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 12/118 (10%) Frame = +1 Query: 259 RSQPIEVPAIPLDEIKEITKNFSSDAL-----IGEGSYARVFLGVL-----KDGKNSAVK 408 R Q +E+ + + K K A+ +GE ++ +++ G L + A+K Sbjct: 447 RGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVAIK 506 Query: 409 RLDSSKQPDQ--EFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L P Q EF + S ++ L H N++ LLG + +EY +G LH+ L Sbjct: 507 TLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFL 564
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 40.0 bits (92), Expect = 0.005 Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 12/118 (10%) Frame = +1 Query: 259 RSQPIEVPAIPLDEIKEITKNFSSDAL-----IGEGSYARVFLGVL-----KDGKNSAVK 408 R Q +E+ + + K K A+ +GE ++ +++ G L + A+K Sbjct: 447 RGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIK 506 Query: 409 RLDSSKQPDQ--EFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L P Q EF + S ++ L H N++ LLG + +EY +G LH+ L Sbjct: 507 TLKDYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFL 564
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 40.0 bits (92), Expect = 0.005 Identities = 25/97 (25%), Positives = 43/97 (44%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 IP +K + K +G G + V++G K+ A+K L + FL + + + Sbjct: 229 IPRQSLKLVRK-------LGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVM 281 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L+H+ +++L I+ EY RG L D L Sbjct: 282 KTLQHERLVRLYAVVTREPIYIVT-EYMARGCLLDFL 317
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 40.0 bits (92), Expect = 0.005 Identities = 23/79 (29%), Positives = 36/79 (45%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V+ G+ + AVK L +EFL + S + +L+H +IQL C Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTKE 305 Query: 520 STRILAYEYATRGSLHDVL 576 + E GSL + L Sbjct: 306 EPIYIVTELMKHGSLLEYL 324
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 40.0 bits (92), Expect = 0.005 Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 7/96 (7%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVK-------RLDSSKQPDQEFLVQV 456 E++ T +S D +G+G + V+ G K + A+K +D Q+ ++ Sbjct: 205 ELENATDGWSPDNRLGQGGFGDVYRGKWKQ-LDVAIKVMNYRSPNIDQKMVELQQSYNEL 263 Query: 457 SAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 ++ ++HDN++ L GY G L Y+ GSL Sbjct: 264 KYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSL 299
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 39.7 bits (91), Expect = 0.006 Identities = 21/79 (26%), Positives = 35/79 (44%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V LG K + AVK + + EF + + +L H +++ G C+ Sbjct: 399 LGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKK 458 Query: 520 STRILAYEYATRGSLHDVL 576 + EY T G L + L Sbjct: 459 YPIYIVTEYITNGCLLNYL 477
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 39.7 bits (91), Expect = 0.006 Identities = 20/79 (25%), Positives = 34/79 (43%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V G + N A+K + + EF+ + + L H+ ++QL G C Sbjct: 406 LGTGQFGVVKYGKWRGQYNVAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLYGVCTKQ 465 Query: 520 STRILAYEYATRGSLHDVL 576 + EY G L + L Sbjct: 466 RPIFIITEYMANGCLLNFL 484
>ATG1_YEAST (P53104) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Autophagy protein 3) (Cytoplasm to vacuole targeting protein 10) Length = 897 Score = 39.7 bits (91), Expect = 0.006 Identities = 22/88 (25%), Positives = 48/88 (54%), Gaps = 6/88 (6%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGVLKDGKNS--AVKRLDSSKQPDQEFL----VQVSAVSRLKH 480 N++++ IG+GS+A V+ G L K+ A+K + +K +++ L ++++ + ++KH Sbjct: 23 NYTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKH 82 Query: 481 DNVIQLLGYCALGSTRILAYEYATRGSL 564 +++ L+ + L EY G L Sbjct: 83 PHIVGLIDCERTSTDFYLIMEYCALGDL 110
>MERTK_HUMAN (Q12866) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 999 Score = 39.7 bits (91), Expect = 0.006 Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 12/92 (13%) Frame = +1 Query: 337 LIGEGSYARVFLGVLKDGKNSAVK------RLDSSKQPD-QEFLVQVSAVSRLKHDNVIQ 495 ++GEG + V G LK +++K +LD+S + +EFL + + + H NVI+ Sbjct: 592 ILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIR 651 Query: 496 LLGYCALGSTR-----ILAYEYATRGSLHDVL 576 LLG C S++ ++ + G LH L Sbjct: 652 LLGVCIEMSSQGIPKPMVILPFMKYGDLHTYL 683
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 39.7 bits (91), Expect = 0.006 Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNS----AVKRLDS-SKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V L G+ KD N AVK L S + + D L+ + ++ KH N Sbjct: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 542 IINLLGACTQDGPLYVIVEYASKGNLREYL 571
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 39.7 bits (91), Expect = 0.006 Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNS----AVKRLDS-SKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V L G+ KD N AVK L S + + D L+ + ++ KH N Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYL 573
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 39.7 bits (91), Expect = 0.006 Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNS----AVKRLDS-SKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V L G+ KD N AVK L S + + D L+ + ++ KH N Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYL 573
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 39.7 bits (91), Expect = 0.006 Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNS----AVKRLDS-SKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V L G+ KD N AVK L S + + D L+ + ++ KH N Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYL 573
>ROR2_HUMAN (Q01974) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Length = 943 Score = 39.3 bits (90), Expect = 0.008 Identities = 35/124 (28%), Positives = 57/124 (45%), Gaps = 14/124 (11%) Frame = +1 Query: 247 IRTSRSQPIEVPAI------PLDEIKEITKNFSSDALIGEGSYARVFLGVL------KDG 390 + S SQ +E+P I L EI F + +GE + +V+ G L + Sbjct: 444 LMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEE--LGEDRFGKVYKGHLFGPAPGEQT 501 Query: 391 KNSAVKRL-DSSKQP-DQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 + A+K L D ++ P +EF + +RL+H NV+ LLG + + Y + G L Sbjct: 502 QAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDL 561 Query: 565 HDVL 576 H+ L Sbjct: 562 HEFL 565
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 39.3 bits (90), Expect = 0.008 Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNSAV----KRL-DSSKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V + G+ KD AV K L D + + D LV + ++ KH N Sbjct: 489 LGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 548 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 549 IINLLGACTQDGPLYVIVEYASKGNLREYL 578
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 39.3 bits (90), Expect = 0.008 Identities = 21/80 (26%), Positives = 40/80 (50%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+H+ +++L Y + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVRL--YAVVS 329 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY ++GSL D L Sbjct: 330 EEPIYIVTEYMSKGSLLDFL 349
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 39.3 bits (90), Expect = 0.008 Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNSAV----KRL-DSSKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V + G+ KD AV K L D + + D LV + ++ KH N Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 547 IINLLGACTQDGPLYVIVEYASKGNLREYL 576
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 39.3 bits (90), Expect = 0.008 Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 11/90 (12%) Frame = +1 Query: 340 IGEGSYARVFL----GVLKDGKNSAV----KRL-DSSKQPDQEFLVQVSAVSRL--KHDN 486 +GEG + +V + G+ KD AV K L D + + D LV + ++ KH N Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +I LLG C + EYA++G+L + L Sbjct: 547 IINLLGACTQDGPLYVIVEYASKGNLREYL 576
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 39.3 bits (90), Expect = 0.008 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 266 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 325 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 326 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 354
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 39.3 bits (90), Expect = 0.008 Identities = 19/56 (33%), Positives = 29/56 (51%) Frame = +1 Query: 409 RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 R D++K +FL ++ +SRLK N+I+LL C + EY G L+ L Sbjct: 611 RADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFL 666
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 39.3 bits (90), Expect = 0.008 Identities = 32/126 (25%), Positives = 54/126 (42%), Gaps = 9/126 (7%) Frame = +1 Query: 226 GSVPTHAIRTSR--SQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNS 399 G P + + R + P P+ P + + LIG G + +V+ + G+ Sbjct: 90 GIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQ-GQEV 148 Query: 400 AVKRLDSSKQPDQEFLVQVSAVSR-------LKHDNVIQLLGYCALGSTRILAYEYATRG 558 AVK + + P+Q+ +V R L+H N+I+L G C L E+A G Sbjct: 149 AVKA--ARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGG 206 Query: 559 SLHDVL 576 +L+ L Sbjct: 207 ALNRAL 212
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 39.3 bits (90), Expect = 0.008 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 340 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 341 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 369
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 39.3 bits (90), Expect = 0.008 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 340 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 341 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 369
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 39.3 bits (90), Expect = 0.008 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 340 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 341 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 369
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 39.3 bits (90), Expect = 0.008 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 340 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 341 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 369
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 39.3 bits (90), Expect = 0.008 Identities = 21/82 (25%), Positives = 42/82 (51%), Gaps = 4/82 (4%) Frame = +1 Query: 340 IGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLV---QVSAVSRLKHDNVIQLLGY 507 +G+G++ V+ G+ +K+G+ AVK++ SK + V ++ + L H N+++ G Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 508 CALGSTRILAYEYATRGSLHDV 573 + + EY GSL + Sbjct: 75 YQTNDSLCIILEYCENGSLRSI 96
>DDR2_HUMAN (Q16832) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 855 Score = 39.3 bits (90), Expect = 0.008 Identities = 19/56 (33%), Positives = 28/56 (50%) Frame = +1 Query: 409 RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 R D++K +FL ++ +SRLK N+I LL C + EY G L+ L Sbjct: 611 RADANKNARNDFLKEIKIMSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLNQFL 666
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 39.3 bits (90), Expect = 0.008 Identities = 27/96 (28%), Positives = 48/96 (50%), Gaps = 3/96 (3%) Frame = +1 Query: 298 EIKEITKNFSSDALIGEGSYARVFLGVLKD-GKNSAVKRLDSSKQPDQEFLVQ--VSAVS 468 E + + + +IG+G++A V + + GK A+K +D +K +E L++ VS + Sbjct: 386 ESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 445 Query: 469 RLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 R+KH N+I L+ + L E G L D + Sbjct: 446 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAI 481
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 39.3 bits (90), Expect = 0.008 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+HD ++ L Y + Sbjct: 280 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPL--YAVVS 337 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + E+ T+GSL D L Sbjct: 338 EEPIYIVTEFMTKGSLLDFL 357
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+HD ++ L Y + Sbjct: 273 LGQGCFGEVWMGTWNGTTKVAIKTLKLGTMMPEAFLQEAQIMKKLRHDKLVPL--YAVVS 330 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + E+ T+GSL D L Sbjct: 331 EEPIYIVTEFMTKGSLLDFL 350
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 38.9 bits (89), Expect = 0.011 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 268 KKYTPFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 327 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 328 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 356
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 38.9 bits (89), Expect = 0.011 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 268 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 327 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 328 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 356
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 38.9 bits (89), Expect = 0.011 Identities = 23/72 (31%), Positives = 39/72 (54%), Gaps = 3/72 (4%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVK--RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 +G G+YA V+ G+ K G A+K +LDS + + ++S + LKHDN+++L Sbjct: 12 LGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLYDVI 71 Query: 511 ALGSTRILAYEY 546 + L +EY Sbjct: 72 HTENKLTLVFEY 83
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 38.9 bits (89), Expect = 0.011 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRL-KHDNV 489 K ++ IG+G+ V+ + + G+ A+K+++ +QP +E ++ V R K+ N+ Sbjct: 267 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 326 Query: 490 IQLLGYCALGSTRILAYEYATRGSLHDVL 576 + L +G + EY GSL DV+ Sbjct: 327 VNYLDSYLVGDELWVVMEYLAGGSLTDVV 355
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 38.9 bits (89), Expect = 0.011 Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 11/107 (10%) Frame = +1 Query: 289 PLDEIKEITK-----NFSSDALIGEGSYARVFLGVLKDGKNSAVK------RLDSSKQPD 435 P + E K N S D ++G G + V G LK + ++ +++ Sbjct: 605 PTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQR 664 Query: 436 QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++FL + S + + H N+I+L G ++ EY GSL L Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFL 711
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 38.9 bits (89), Expect = 0.011 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 2/77 (2%) Frame = +1 Query: 352 SYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQV-SAVSRLKHDNVIQLLG-YCALGST 525 SY V+ L DG N A++ L D+ + V + R++H+N++ L Y Sbjct: 383 SYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGE 442 Query: 526 RILAYEYATRGSLHDVL 576 ++L Y+Y SLHD+L Sbjct: 443 KLLIYDYLPNISLHDLL 459
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 38.9 bits (89), Expect = 0.011 Identities = 25/93 (26%), Positives = 39/93 (41%), Gaps = 7/93 (7%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGVLK---DGKNSAVKRLDSSKQPDQE----FLVQVSAVSRLK 477 N + +G G + VFL K D + A+ + S + D++ F + +L Sbjct: 776 NLQTITTLGRGEFGEVFLAKAKGAEDAEGEALVLVKSLQTRDEQLQLDFRREAEMFGKLN 835 Query: 478 HDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 H NV++LLG C + EY G L L Sbjct: 836 HVNVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 868
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 38.9 bits (89), Expect = 0.011 Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 6/153 (3%) Frame = +1 Query: 136 CGASDVGKKKKRDDPYVPVPAPGGNYGYNRGSV----PTHAIRTSRSQPIEVPAIPLDEI 303 CGAS ++ P P A + G N+ V P +Q I+V Sbjct: 3 CGAS------RKVVPGPPALAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFD 56 Query: 304 KEITKNFSSDALIGEGSYARVFLGVLKDGKNS-AVKRLDSSKQPDQEFLV-QVSAVSRLK 477 + + ALIG GS++RV K K A+K +++ ++ +E V ++S + R+ Sbjct: 57 PRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVS 116 Query: 478 HDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 H ++QL+ + E AT G L D L Sbjct: 117 HRYIVQLMEIFETEDQVYMVMELATGGELFDRL 149
>INSRR_HUMAN (P14616) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1297 Score = 38.9 bits (89), Expect = 0.011 Identities = 26/83 (31%), Positives = 45/83 (54%), Gaps = 8/83 (9%) Frame = +1 Query: 340 IGEGSYARVFLGV---LKDGKNS---AVKRLDSSKQPDQ--EFLVQVSAVSRLKHDNVIQ 495 +G+GS+ V+ G+ L+ G+ S A+K ++ P + EFL + S + K +V++ Sbjct: 985 LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVR 1044 Query: 496 LLGYCALGSTRILAYEYATRGSL 564 LLG + G ++ E TRG L Sbjct: 1045 LLGVVSQGQPTLVIMELMTRGDL 1067
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 38.9 bits (89), Expect = 0.011 Identities = 26/104 (25%), Positives = 48/104 (46%), Gaps = 9/104 (8%) Frame = +1 Query: 292 LDEIKEIT-KNFSSDALIGEGSYARVFLGVLKDGKNS------AVKRLDS--SKQPDQEF 444 + ++KE+ KN + +G G++ V+ G + N AVK L S+Q + +F Sbjct: 1109 ISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDF 1168 Query: 445 LVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L++ +S+ H N+++ +G R + E G L L Sbjct: 1169 LMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFL 1212
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 38.9 bits (89), Expect = 0.011 Identities = 26/104 (25%), Positives = 48/104 (46%), Gaps = 9/104 (8%) Frame = +1 Query: 292 LDEIKEIT-KNFSSDALIGEGSYARVFLGVLKDGKNS------AVKRLDS--SKQPDQEF 444 + ++KE+ KN + +G G++ V+ G + N AVK L S+Q + +F Sbjct: 1105 ISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDF 1164 Query: 445 LVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L++ +S+ H N+++ +G R + E G L L Sbjct: 1165 LMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL 1208
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/79 (27%), Positives = 35/79 (44%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V++G D AVK L FL + + + +L+H +++L Sbjct: 250 LGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE 309 Query: 520 STRILAYEYATRGSLHDVL 576 I+ EY GSL D L Sbjct: 310 PIYIIT-EYMENGSLVDFL 327
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 38.9 bits (89), Expect = 0.011 Identities = 34/117 (29%), Positives = 54/117 (46%), Gaps = 9/117 (7%) Frame = +1 Query: 241 HAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLKD--GKNS----- 399 +AI T +Q E+ +P +++T L+G G++ V+ G D G S Sbjct: 1923 YAIHTLPTQE-EIENLPAFPREKLTLRL----LLGSGAFGEVYEGTAVDILGVGSGEIKV 1977 Query: 400 AVKRLD--SSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSL 564 AVK L S+ Q EFL + +S+ H N+++ LG C L + + E G L Sbjct: 1978 AVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDL 2034
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 38.9 bits (89), Expect = 0.011 Identities = 23/79 (29%), Positives = 45/79 (56%), Gaps = 7/79 (8%) Frame = +1 Query: 349 GSYARVFLGVLKDGKNSAVK--RLDSSKQP-----DQEFLVQVSAVSRLKHDNVIQLLGY 507 G+++R++ G+ K + AVK R+ + K+ +Q+F +V+ +SRL H N++Q + Sbjct: 95 GAHSRIYRGIYKQ-RAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIAA 153 Query: 508 CALGSTRILAYEYATRGSL 564 C + EY ++G+L Sbjct: 154 CKKPPVYCIITEYMSQGNL 172
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V++G K+ A+K L + FL + + + L+H+ +++L Y + Sbjct: 246 LGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANMMKALQHERLVRL--YAVVT 303 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + EY RG L D L Sbjct: 304 KEPIYIVTEYMARGCLLDFL 323
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 38.5 bits (88), Expect = 0.014 Identities = 27/82 (32%), Positives = 41/82 (50%), Gaps = 3/82 (3%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRL---DSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 IG GS+ V G + AVK L D + EFL +V+ + RL+H N++ +G Sbjct: 557 IGAGSFGTVHRAEWH-GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAV 615 Query: 511 ALGSTRILAYEYATRGSLHDVL 576 + EY +RGSL+ +L Sbjct: 616 TQPPNLSIVTEYLSRGSLYRLL 637
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 38.5 bits (88), Expect = 0.014 Identities = 20/79 (25%), Positives = 35/79 (44%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V LG K + AVK + + EF + + +L H +++ G C+ Sbjct: 423 LGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKE 482 Query: 520 STRILAYEYATRGSLHDVL 576 + EY + G L + L Sbjct: 483 YPIYIVTEYISNGCLLNYL 501
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 38.5 bits (88), Expect = 0.014 Identities = 36/134 (26%), Positives = 65/134 (48%), Gaps = 14/134 (10%) Frame = +1 Query: 217 YNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFS----SDALIGEGSYARVFLGV-L 381 ++ GS P+ + S P + + ++E T + S ALIG GS+ +V+LG+ Sbjct: 355 FSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVYLGMNA 414 Query: 382 KDGKNSAVKR--LDS-SKQPDQEFLV------QVSAVSRLKHDNVIQLLGYCALGSTRIL 534 G+ AVK+ LDS S+ D+ + +++ + L H++++Q LG + Sbjct: 415 SSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNI 474 Query: 535 AYEYATRGSLHDVL 576 EY GS+ +L Sbjct: 475 FLEYVPGGSVAGLL 488
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 38.5 bits (88), Expect = 0.014 Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 8/95 (8%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVFLGVLKDGKNSA------VKRLDSSKQPDQ--EFLVQVSAVSR 471 KN +GEG + +V K A VK L + P + + L + + + + Sbjct: 722 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQ 781 Query: 472 LKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + H +VI+L G C+ +L EYA GSL L Sbjct: 782 VNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL 816
>INSRR_CAVPO (P14617) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 38.5 bits (88), Expect = 0.014 Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 8/83 (9%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD---GKNS---AVKRLDSSKQPDQ--EFLVQVSAVSRLKHDNVIQ 495 +G+GS+ V+ GV K G+ S A+K ++ P + EFL + S + + +V++ Sbjct: 985 LGQGSFGMVYEGVAKGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFQCHHVVR 1044 Query: 496 LLGYCALGSTRILAYEYATRGSL 564 LLG + G ++ E TRG L Sbjct: 1045 LLGVVSQGQPTLVIMELMTRGDL 1067
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 38.5 bits (88), Expect = 0.014 Identities = 19/79 (24%), Positives = 34/79 (43%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V G + + A+K + + EF+ + + L H+ ++QL G C Sbjct: 407 LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ 466 Query: 520 STRILAYEYATRGSLHDVL 576 + EY G L + L Sbjct: 467 RPIFIITEYMANGCLLNYL 485
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 38.5 bits (88), Expect = 0.014 Identities = 36/148 (24%), Positives = 65/148 (43%), Gaps = 8/148 (5%) Frame = +1 Query: 157 KKKKRDDPYVPVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSS-- 330 K+ + + P PGG+ Y P I++ + +V + + S Sbjct: 404 KRPQEELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIE 463 Query: 331 -DALIGEGSYARVFLGVLKDGKNSAVKRLDS----SKQPDQEFLVQVSAVSRLKHDNVIQ 495 +IG GS+ +V+ G ++ K A+KR + SK F +VS + +L H V+Q Sbjct: 464 FHEIIGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQ 522 Query: 496 LLGYCALGSTRI-LAYEYATRGSLHDVL 576 +G C ++ + +Y + GSL +L Sbjct: 523 FVGACLDDPSQFAIVTQYISGGSLFSLL 550
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 38.5 bits (88), Expect = 0.014 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Frame = +1 Query: 331 DALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 D +G+G + V++G A+K L + FL + + +L+HD ++ L Y Sbjct: 280 DVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVPL--YA 337 Query: 511 ALGSTRI-LAYEYATRGSLHDVL 576 + I + E+ +GSL D L Sbjct: 338 VVSEEPIYIVTEFMGKGSLLDFL 360
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 38.5 bits (88), Expect = 0.014 Identities = 23/86 (26%), Positives = 47/86 (54%), Gaps = 7/86 (8%) Frame = +1 Query: 340 IGEGSYARVFLG----VLKDGKNS--AVKRL-DSSKQPDQEFLVQVSAVSRLKHDNVIQL 498 +GEG++ +VFL +L + + + AVK L + ++ +F + ++ L+H+++++ Sbjct: 499 LGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVKF 558 Query: 499 LGYCALGSTRILAYEYATRGSLHDVL 576 G C G I+ +EY G L+ L Sbjct: 559 YGVCTEGDPLIMVFEYMKHGDLNRFL 584
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 38.1 bits (87), Expect = 0.018 Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 4/73 (5%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQ----PDQEFLVQVSAVSRLKHDNVIQLLGY 507 IGEG+Y V+ DG++ A+K++ K+ P + ++S + L+H N+++L Sbjct: 10 IGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTVSIREISILKELRHSNIVKLYDV 69 Query: 508 CALGSTRILAYEY 546 IL +E+ Sbjct: 70 IHAKKRLILVFEH 82
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 38.1 bits (87), Expect = 0.018 Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 6/92 (6%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGVLKDGKNS----AVKRLDS--SKQPDQEFLVQVSAVSRLKH 480 N S D ++G G + V G LK A+K L + +++ ++FL + S + + H Sbjct: 620 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDH 679 Query: 481 DNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 N+I+L G ++ EY GSL L Sbjct: 680 PNIIRLEGVVTKSKPVMIVTEYMENGSLDSFL 711
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 38.1 bits (87), Expect = 0.018 Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Frame = +1 Query: 340 IGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPD---QEFLVQVSAVSRLKHDNVIQLLGY 507 IG+G++A+V L + GK AVK +D ++ Q+ +V + L H N+++L Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV 118 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 T L EYA+ G + D L Sbjct: 119 IETEKTLYLVMEYASGGEVFDYL 141
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 38.1 bits (87), Expect = 0.018 Identities = 19/79 (24%), Positives = 34/79 (43%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V G + + A+K + + EF+ + + L H+ ++QL G C Sbjct: 407 LGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ 466 Query: 520 STRILAYEYATRGSLHDVL 576 + EY G L + L Sbjct: 467 RPIFIITEYMANGCLLNYL 485
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 38.1 bits (87), Expect = 0.018 Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Frame = +1 Query: 340 IGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPD---QEFLVQVSAVSRLKHDNVIQLLGY 507 IG+G++A+V L + GK AVK +D ++ Q+ +V + L H N+++L Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV 118 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 T L EYA+ G + D L Sbjct: 119 IETEKTLYLVMEYASGGEVFDYL 141
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 38.1 bits (87), Expect = 0.018 Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 3/83 (3%) Frame = +1 Query: 337 LIGEGSYARVFLGVLK-DGKNSAVKRLDSSKQPDQEFLVQ--VSAVSRLKHDNVIQLLGY 507 +IG+G++A V V + GK A+K +D +K +E L++ VS + R+KH N+I L+ Sbjct: 398 VIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEE 457 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 + L E G L D + Sbjct: 458 METATDLFLVMELVKGGDLFDAI 480
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 38.1 bits (87), Expect = 0.018 Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Frame = +1 Query: 340 IGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPD---QEFLVQVSAVSRLKHDNVIQLLGY 507 IG+G++A+V L + GK AVK +D ++ Q+ +V + L H N+++L Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV 118 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 T L EYA+ G + D L Sbjct: 119 IETEKTLYLVMEYASGGEVFDYL 141
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 37.7 bits (86), Expect = 0.024 Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 3/72 (4%) Frame = +1 Query: 340 IGEGSYARVFLGVLKD-GKNSAVK--RLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 +G G+YA V+ G+ K G A+K +LDS + + ++S + LKHDN+++L Sbjct: 13 VGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLFDVI 72 Query: 511 ALGSTRILAYEY 546 + L +E+ Sbjct: 73 HTENKLTLVFEF 84
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 37.7 bits (86), Expect = 0.024 Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 10/134 (7%) Frame = +1 Query: 205 GNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGV-L 381 G G S+ + I P +PA +E I + LIG G++ RV++G+ L Sbjct: 31 GFVGKINSSIRSSRIGLFSKPPPGLPAPRKEEAPSI--RWRKGELIGCGAFGRVYMGMNL 88 Query: 382 KDGKNSAVKRL-----DSSKQPDQ----EFLVQVSAVSRLKHDNVIQLLGYCALGSTRIL 534 G+ A+K++ +SK+ Q E +V + L H N+++ LG + + Sbjct: 89 DSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNI 148 Query: 535 AYEYATRGSLHDVL 576 E+ GS+ +L Sbjct: 149 LMEFVPGGSISSLL 162
>MERTK_MOUSE (Q60805) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 37.7 bits (86), Expect = 0.024 Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 7/65 (10%) Frame = +1 Query: 337 LIGEGSYARVFLGVLK--DGKNSAVK----RLDSSKQPD-QEFLVQVSAVSRLKHDNVIQ 495 ++GEG + V G LK DG + V +LD+ Q + +EFL + + + H NVI+ Sbjct: 587 VLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIR 646 Query: 496 LLGYC 510 LLG C Sbjct: 647 LLGVC 651
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 37.7 bits (86), Expect = 0.024 Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 11/107 (10%) Frame = +1 Query: 289 PLDEIKEITK-----NFSSDALIGEGSYARVFLGVLKDGKNSAVK------RLDSSKQPD 435 P + E K N S D ++G G + V G LK + ++ +++ Sbjct: 605 PTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQR 664 Query: 436 QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++FL + S + + H N+I+L G ++ EY GSL L Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFL 711
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 37.7 bits (86), Expect = 0.024 Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+HD ++ L Y + Sbjct: 280 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPL--YAVVS 337 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + E+ ++GSL D L Sbjct: 338 EEPIYIVTEFMSKGSLLDFL 357
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 37.7 bits (86), Expect = 0.024 Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 8/102 (7%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVF----LGVLKDGKNS--AVKRLD--SSKQPDQEFLV 450 DE + + + + +G+GS+ V+ GV+KD + A+K ++ +S + EFL Sbjct: 991 DEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1050 Query: 451 QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + S + +V++LLG + G ++ E TRG L L Sbjct: 1051 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYL 1092
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 37.7 bits (86), Expect = 0.024 Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 11/107 (10%) Frame = +1 Query: 289 PLDEIKEITKNFSS-----DALIGEGSYARVFLGVLK-DGKNS---AVKRLDS--SKQPD 435 P + ++E K + +IG G + V G LK GK A+K L S +++ Sbjct: 623 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQR 682 Query: 436 QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++FL + S + + H NVI L G S ++ E+ GSL L Sbjct: 683 RDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFL 729
>SHARK_DROME (Q24145) Tyrosine-protein kinase shark (EC 2.7.10.2)| Length = 939 Score = 37.7 bits (86), Expect = 0.024 Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 8/86 (9%) Frame = +1 Query: 331 DALIGEGSYARVFLGVL--KDGKNS------AVKRLDSSKQPDQEFLVQVSAVSRLKHDN 486 D IG G + V G L K G A+K L QEFL + S + RL+H Sbjct: 665 DREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKC 724 Query: 487 VIQLLGYCALGSTRILAYEYATRGSL 564 +++L+G A G ++ E A GS+ Sbjct: 725 IVRLIG-IAKGEMLMMVQELAPLGSM 749
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 37.7 bits (86), Expect = 0.024 Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 8/102 (7%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVF----LGVLKDGKNS--AVKRLD--SSKQPDQEFLV 450 DE + + + + +G+GS+ V+ GV+KD + A+K ++ +S + EFL Sbjct: 991 DEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1050 Query: 451 QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + S + +V++LLG + G ++ E TRG L L Sbjct: 1051 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYL 1092
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 37.7 bits (86), Expect = 0.024 Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G+G + V++G A+K L + FL + + +L+HD ++ L Y + Sbjct: 282 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPL--YAVVS 339 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + E+ ++GSL D L Sbjct: 340 EEPIYIVTEFMSKGSLLDFL 359
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 37.7 bits (86), Expect = 0.024 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 8/88 (9%) Frame = +1 Query: 337 LIGEGSYARVFLGVLKD--GKNS----AVKRLDSSKQPD--QEFLVQVSAVSRLKHDNVI 492 +IGEG++ RVFLG KN AVK L S ++F + ++ ++H N++ Sbjct: 509 VIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIV 568 Query: 493 QLLGYCALGSTRILAYEYATRGSLHDVL 576 G C ++ +E+ G L+ L Sbjct: 569 TFYGVCTESDQWMMIFEFMENGDLNKYL 596
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 37.7 bits (86), Expect = 0.024 Identities = 37/148 (25%), Positives = 66/148 (44%), Gaps = 9/148 (6%) Frame = +1 Query: 160 KKKRDD-PYVPVPAPGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSS-- 330 K+ +D+ P PGG+ Y P I++ + +V + + S Sbjct: 403 KRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIE 462 Query: 331 -DALIGEGSYARVFLGVLKDGKNSAVKRLDS----SKQPDQEFLVQVSAVSRLKHDNVIQ 495 +IG GS+ +V+ G ++ K A+KR + SK F +VS + +L H V+Q Sbjct: 463 FHEIIGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQ 521 Query: 496 LLGYCALGSTRI-LAYEYATRGSLHDVL 576 +G C ++ + +Y + GSL +L Sbjct: 522 FVGACLDDPSQFAIVTQYISGGSLFSLL 549
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 37.7 bits (86), Expect = 0.024 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 4/90 (4%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPD---QEFLVQVSAVSRLKHDN 486 N+ IG+G++A+V L + G+ AVK +D ++ Q+ +V + L H N Sbjct: 59 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 118 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++L T L EYA+ G + D L Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYL 148
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 37.7 bits (86), Expect = 0.024 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 4/90 (4%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPD---QEFLVQVSAVSRLKHDN 486 N+ IG+G++A+V L + G+ AVK +D ++ Q+ +V + L H N Sbjct: 59 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 118 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++L T L EYA+ G + D L Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYL 148
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 37.7 bits (86), Expect = 0.024 Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLD---SSKQPDQEFLVQVSAVSRLKHDNVIQLLGYC 510 +GEG+++ V+ G K G + A+K+L +Q + F+ +V + + H N++ +G C Sbjct: 114 VGEGAFSEVWEGWWK-GIHVAIKKLKIIGDEEQFKERFIREVQNLKKGNHQNIVMFIGAC 172 Query: 511 ALGSTRILAYEYATRGSLHDVL 576 + EY GSL+++L Sbjct: 173 Y--KPACIITEYMAGGSLYNIL 192
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase| 2) (JAK-2) Length = 1132 Score = 37.7 bits (86), Expect = 0.024 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 9/88 (10%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSA--------VKRLDSS-KQPDQEFLVQVSAVSRLKHDNVI 492 +G+G++ ++F GV ++ + +K LD + + + F S +S+L H +++ Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 610 Query: 493 QLLGYCALGSTRILAYEYATRGSLHDVL 576 G C G IL E+ GSL L Sbjct: 611 LNYGVCVCGDENILVQEFVKFGSLDTYL 638 Score = 35.4 bits (80), Expect = 0.12 Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL---GVLKD--GKNSAVKRLDSSKQPD-QEFLVQVSAVSRLKHDNVIQLL 501 +G+G++ V + L+D G+ AVK+L S + ++F ++ + L+HDN+++ Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 502 GYCALGSTR--ILAYEYATRGSLHDVL 576 G C R L EY GSL D L Sbjct: 915 GVCYSAGRRNLKLIMEYLPYGSLRDYL 941
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 37.7 bits (86), Expect = 0.024 Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 11/107 (10%) Frame = +1 Query: 289 PLDEIKEITKNFSS-----DALIGEGSYARVFLGVLK-DGKNS---AVKRLDS--SKQPD 435 P + ++E K + +IG G + V G LK GK A+K L S +++ Sbjct: 606 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQR 665 Query: 436 QEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 ++FL + S + + H NVI L G S ++ E+ GSL L Sbjct: 666 RDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFL 712
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 37.7 bits (86), Expect = 0.024 Identities = 31/132 (23%), Positives = 51/132 (38%), Gaps = 5/132 (3%) Frame = +1 Query: 196 APGGNYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLG 375 APG N+ T + + QP + NF +G+G + V+L Sbjct: 52 APGQKLAENKSQGSTASQGSQNKQPFTID------------NFEIGRPLGKGKFGNVYLA 99 Query: 376 VLKDGKNSAVKRLDSSKQPDQEFLV-----QVSAVSRLKHDNVIQLLGYCALGSTRILAY 540 K + ++ Q ++E + ++ + LKH N++QL Y L Sbjct: 100 REKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLIL 159 Query: 541 EYATRGSLHDVL 576 EYA RG L+ L Sbjct: 160 EYAPRGELYKEL 171
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 37.7 bits (86), Expect = 0.024 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 4/90 (4%) Frame = +1 Query: 319 NFSSDALIGEGSYARVFLGV-LKDGKNSAVKRLDSSKQPD---QEFLVQVSAVSRLKHDN 486 N+ IG+G++A+V L + G+ AVK +D ++ Q+ +V + L H N Sbjct: 59 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 118 Query: 487 VIQLLGYCALGSTRILAYEYATRGSLHDVL 576 +++L T L EYA+ G + D L Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYL 148
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 37.7 bits (86), Expect = 0.024 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 3/89 (3%) Frame = +1 Query: 253 TSRSQPIEVPAIPLDEIKEITKNFSSDALIGEGSYARVFLGVLK-DGKNSAVKRLDSSKQ 429 T +S + A+P D+ ++ IG G++ VF G L+ D AVK + Sbjct: 536 TKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLP 595 Query: 430 PD--QEFLVQVSAVSRLKHDNVIQLLGYC 510 PD +FL + + + H N+++L+G C Sbjct: 596 PDLKAKFLQEARILKQYNHPNIVRLIGVC 624
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 37.7 bits (86), Expect = 0.024 Identities = 24/80 (30%), Positives = 41/80 (51%), Gaps = 3/80 (3%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNS-AVKRLDSSKQPD--QEFLVQVSAVSRLKHDNVIQLLGYC 510 +GEG+Y V L V + + + AVK +D + D + ++ L H+NV++ G+ Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 511 ALGSTRILAYEYATRGSLHD 570 G+ + L EY + G L D Sbjct: 75 REGNIQYLFLEYCSGGELFD 94
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 37.4 bits (85), Expect = 0.031 Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 4/83 (4%) Frame = +1 Query: 340 IGEGSYARVFLGV-LKDGKNSAVKRLDSSK-QPD--QEFLVQVSAVSRLKHDNVIQLLGY 507 IG+G++A+V L + G+ A+K +D ++ P Q+ +V + L H N+++L Sbjct: 65 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEV 124 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 T L EYA+ G + D L Sbjct: 125 IETEKTLYLVMEYASAGEVFDYL 147
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 37.4 bits (85), Expect = 0.031 Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 4/83 (4%) Frame = +1 Query: 340 IGEGSYARVFLGV-LKDGKNSAVKRLDSSK-QPD--QEFLVQVSAVSRLKHDNVIQLLGY 507 IG+G++A+V L + G+ A+K +D ++ P Q+ +V + L H N+++L Sbjct: 65 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEV 124 Query: 508 CALGSTRILAYEYATRGSLHDVL 576 T L EYA+ G + D L Sbjct: 125 IETEKTLYLVMEYASAGEVFDYL 147
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 37.4 bits (85), Expect = 0.031 Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 8/102 (7%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVF----LGVLKDGKNS--AVKRLD--SSKQPDQEFLV 450 DE + + + +G+GS+ V+ GV+KD + A+K ++ +S + EFL Sbjct: 263 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 322 Query: 451 QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + S + +V++LLG + G ++ E TRG L L Sbjct: 323 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYL 364
>INSRR_MOUSE (Q9WTL4) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 37.4 bits (85), Expect = 0.031 Identities = 26/83 (31%), Positives = 46/83 (55%), Gaps = 8/83 (9%) Frame = +1 Query: 340 IGEGSYARVFLGV---LKDGKNS---AVKRLD--SSKQPDQEFLVQVSAVSRLKHDNVIQ 495 +G+GS+ V+ G+ L+ G+ S A+K ++ +S + EFL + S + K +V++ Sbjct: 985 LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVR 1044 Query: 496 LLGYCALGSTRILAYEYATRGSL 564 LLG + G ++ E TRG L Sbjct: 1045 LLGVVSQGQPTLVIMELMTRGDL 1067
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 37.4 bits (85), Expect = 0.031 Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 8/102 (7%) Frame = +1 Query: 295 DEIKEITKNFSSDALIGEGSYARVF----LGVLKDGKNS--AVKRLD--SSKQPDQEFLV 450 DE + + + +G+GS+ V+ GV+KD + A+K ++ +S + EFL Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049 Query: 451 QVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 + S + +V++LLG + G ++ E TRG L L Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYL 1091
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 37.4 bits (85), Expect = 0.031 Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 1/80 (1%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALG 519 +G G + V+LG AVK L + FL + + L+HD ++QL Y + Sbjct: 269 LGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQL--YAVVS 326 Query: 520 STRI-LAYEYATRGSLHDVL 576 I + E+ GSL D L Sbjct: 327 EEPIYIVTEFMCHGSLLDFL 346
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase| 2) (JAK-2) Length = 1132 Score = 37.4 bits (85), Expect = 0.031 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 9/88 (10%) Frame = +1 Query: 340 IGEGSYARVFLGVLKDGKNSA--------VKRLDSS-KQPDQEFLVQVSAVSRLKHDNVI 492 +G+G++ ++F GV ++ + +K LD + + + F S +S+L H +++ Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 493 QLLGYCALGSTRILAYEYATRGSLHDVL 576 G C G IL E+ GSL L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYL 638 Score = 35.4 bits (80), Expect = 0.12 Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 8/87 (9%) Frame = +1 Query: 340 IGEGSYARVFL---GVLKD--GKNSAVKRLDSSKQPD-QEFLVQVSAVSRLKHDNVIQLL 501 +G+G++ V + L+D G+ AVK+L S + ++F ++ + L+HDN+++ Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 502 GYCALGSTR--ILAYEYATRGSLHDVL 576 G C R L EY GSL D L Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYL 941
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 37.4 bits (85), Expect = 0.031 Identities = 30/125 (24%), Positives = 61/125 (48%), Gaps = 2/125 (1%) Frame = +1 Query: 208 NYGYNRGSVPTHAIRTSRSQPIEVPAIPLDEIKEIT--KNFSSDALIGEGSYARVFLGVL 381 +Y ++G++ T +R R + L + ++ + A IGEG + V G Sbjct: 195 HYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEY 254 Query: 382 KDGKNSAVKRLDSSKQPDQEFLVQVSAVSRLKHDNVIQLLGYCALGSTRILAYEYATRGS 561 G+ AVK + Q FL + + +++++H+N+++LLG L + E+ ++G+ Sbjct: 255 L-GQKVAVKNIKCDVTA-QAFLDETAVMTKMQHENLVRLLG-VILHQGLYIVMEHVSKGN 311 Query: 562 LHDVL 576 L + L Sbjct: 312 LVNFL 316
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 37.4 bits (85), Expect = 0.031 Identities = 23/97 (23%), Positives = 41/97 (42%) Frame = +1 Query: 286 IPLDEIKEITKNFSSDALIGEGSYARVFLGVLKDGKNSAVKRLDSSKQPDQEFLVQVSAV 465 +P + +K + K +G G + V++G A+K L FL + + + Sbjct: 238 VPRESLKLVEK-------LGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSPSAFLAEANLM 290 Query: 466 SRLKHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L+H +++L I+ EY +GSL D L Sbjct: 291 KNLQHPRLVRLYAVVTKEPIYIIT-EYMEKGSLVDFL 326
>FLT3_MOUSE (Q00342) FL cytokine receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) Length = 992 Score = 37.4 bits (85), Expect = 0.031 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 9/96 (9%) Frame = +1 Query: 316 KNFSSDALIGEGSYARVF----LGVLKDGKNS--AVKRL-DSSKQPDQEFLV-QVSAVSR 471 +N ++G G++ RV G+ K G + AVK L + + ++E L+ ++ ++ Sbjct: 609 ENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTH 668 Query: 472 L-KHDNVIQLLGYCALGSTRILAYEYATRGSLHDVL 576 L HDN++ LLG C L L +EY G L + L Sbjct: 669 LGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYL 704 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.315 0.135 0.389 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 82,730,465 Number of Sequences: 219361 Number of extensions: 1814098 Number of successful extensions: 5064 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 4832 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4981 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4872342800 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits)
