ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal6j24 |
|---|---|
| Clone Library Name | barley_pub |
>HEMH_ORYSA (O22101) Ferrochelatase-2, chloroplast precursor (EC 4.99.1.1)| (Ferrochelatase II) (Protoheme ferro-lyase 2) (Heme synthetase 2) Length = 526 Score = 343 bits (880), Expect = 2e-94 Identities = 178/212 (83%), Positives = 182/212 (85%), Gaps = 18/212 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADPDIIRLPR RFLQKPLAQFISV RAPKSKEGYASIGGGSPLRQITDAQ EAL + Sbjct: 136 NLFADPDIIRLPRLFRFLQKPLAQFISVVRAPKSKEGYASIGGGSPLRQITDAQAEALRK 195 Query: 184 ALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 ALC KDIPAK IK+DGITKLVVLPLYPQFSISTSGSSLRLLE Sbjct: 196 ALCDKDIPAKVYVGMRYWHPFTEEAIEQIKRDGITKLVVLPLYPQFSISTSGSSLRLLEG 255 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKEL F +PQKVMIFFSAHGVPLAYV Sbjct: 256 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELRTFSEPQKVMIFFSAHGVPLAYV 315 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 EEAGDPYKAEMEECVDLIMEELEKRG+ N CT Sbjct: 316 EEAGDPYKAEMEECVDLIMEELEKRGITNSCT 347
>HEMH2_ARATH (O04921) Ferrochelatase-2, chloroplast precursor (EC 4.99.1.1)| (Ferrochelatase II) (Protoheme ferro-lyase 2) (Heme synthetase 2) Length = 512 Score = 310 bits (795), Expect = 2e-84 Identities = 163/212 (76%), Positives = 173/212 (81%), Gaps = 18/212 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADPDIIRLP +FLQKPLAQFISVARAPKSKEGYASIGGGSPLR ITDAQ E L + Sbjct: 123 NLFADPDIIRLPPVFQFLQKPLAQFISVARAPKSKEGYASIGGGSPLRHITDAQAEELRK 182 Query: 184 ALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L K++PAK IK+DGITKLVVLPLYPQFSISTSGSSLRLLE Sbjct: 183 CLWEKNVPAKVYVGMRYWHPFTEEAIEQIKRDGITKLVVLPLYPQFSISTSGSSLRLLER 242 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 IFREDEYLVNMQHTVIPSWYQREGYIKAMA LI+ EL KF P +V+IFFSAHGVPLAYV Sbjct: 243 IFREDEYLVNMQHTVIPSWYQREGYIKAMANLIQSELGKFGSPNQVVIFFSAHGVPLAYV 302 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 EEAGDPYKAEMEECVDLIMEEL+KR + N T Sbjct: 303 EEAGDPYKAEMEECVDLIMEELDKRKITNAYT 334
>HEMH_CUCSA (P42044) Ferrochelatase-2, chloroplast precursor (EC 4.99.1.1)| (Ferrochelatase II) (Protoheme ferro-lyase 2) (Heme synthetase 2) Length = 514 Score = 258 bits (660), Expect = 7e-69 Identities = 132/212 (62%), Positives = 162/212 (76%), Gaps = 18/212 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADPDIIRLPR RFLQ+PLA+ IS RAPKSKEGYASIGGGSPLR+ITD Q +AL Sbjct: 137 NLFADPDIIRLPRLFRFLQEPLAKLISTYRAPKSKEGYASIGGGSPLRKITDEQAQALKM 196 Query: 184 ALCGKDIPA------------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 AL K++ +IK+DGIT+LVVLPLYPQ+SIST+GSS+R+L+ Sbjct: 197 ALAEKNMSTNVYVGMRYWYPFTEEAIQQIKRDGITRLVVLPLYPQYSISTTGSSIRVLQK 256 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 +FRED YL ++ ++I SWYQREGYIK+MA L++ EL F PQ+VMIFFSAHGVP++YV Sbjct: 257 MFREDAYLSSLPVSIIKSWYQREGYIKSMADLMQAELKNFANPQEVMIFFSAHGVPVSYV 316 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 E AGDPYK +MEEC+ LIM+EL+ RG+ N T Sbjct: 317 ENAGDPYKDQMEECICLIMQELKARGIGNEHT 348
>HEMH_HORVU (P42045) Ferrochelatase-2, chloroplast precursor (EC 4.99.1.1)| (Ferrochelatase II) (Protoheme ferro-lyase 2) (Heme synthetase 2) Length = 484 Score = 255 bits (652), Expect = 6e-68 Identities = 132/212 (62%), Positives = 158/212 (74%), Gaps = 18/212 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADPDIIRLPR RFLQ+PLA+ IS RAPKS EGYASIGGGSPLR+ITD Q AL Sbjct: 131 NLFADPDIIRLPRLFRFLQRPLAKLISTFRAPKSNEGYASIGGGSPLRKITDEQANALKV 190 Query: 184 ALCGKDIPA------------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 AL K++ A +IKKD ITKLVVLPLYPQ+SISTSGSS+R+L++ Sbjct: 191 ALKSKNLEADIYVGMRYWYPFTEEAIDQIKKDKITKLVVLPLYPQYSISTSGSSIRVLQN 250 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 I +ED Y + ++I SWYQREGY+K+MA LIEKEL F P++VMIFFSAHGVPL YV Sbjct: 251 IVKEDPYFAGLPISIIESWYQREGYVKSMADLIEKELSVFSNPEEVMIFFSAHGVPLTYV 310 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 ++AGDPY+ +ME+C+ LIMEEL+ RG N T Sbjct: 311 KDAGDPYRDQMEDCIALIMEELKSRGTLNDHT 342
>HEMH1_ARATH (P42043) Ferrochelatase-1, chloroplast/mitochondrial precursor (EC| 4.99.1.1) (Ferrochelatase I) (Protoheme ferro-lyase 1) (Heme synthetase 1) Length = 466 Score = 253 bits (646), Expect = 3e-67 Identities = 128/209 (61%), Positives = 159/209 (76%), Gaps = 18/209 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADPDIIRLPR +FLQ +A+FISV RAPKSKEGYA+IGGGSPLR+ITD Q +A+ Sbjct: 112 NLFADPDIIRLPRPFQFLQGTIAKFISVVRAPKSKEGYAAIGGGSPLRKITDEQADAIKM 171 Query: 184 ALCGKDIPA------------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +L K+I A +IKKD IT+LVVLPLYPQ+SIST+GSS+R+L+ Sbjct: 172 SLQAKNIAANVYVGMRYWYPFTEEAVQQIKKDKITRLVVLPLYPQYSISTTGSSIRVLQD 231 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 +FR+D YL + +I SWYQR GY+ +MA LIEKEL F P++VMIFFSAHGVP++YV Sbjct: 232 LFRKDPYLAGVPVAIIKSWYQRRGYVNSMADLIEKELQTFSDPKEVMIFFSAHGVPVSYV 291 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGMEN 576 E AGDPY+ +MEEC+DLIMEEL+ RG+ N Sbjct: 292 ENAGDPYQKQMEECIDLIMEELKARGVLN 320
>HEMH_ANASP (Q8YQR8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 388 Score = 212 bits (539), Expect = 7e-55 Identities = 111/204 (54%), Positives = 143/204 (70%), Gaps = 18/204 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF+DP+IIRLP R+LQKPLA FI+ R S+E Y IGGGSPLR+IT+AQGEAL E Sbjct: 26 NLFSDPEIIRLP--FRWLQKPLAWFIASRRTKTSQENYKQIGGGSPLRRITEAQGEALKE 83 Query: 184 AL------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L ++ A + +D + LV+LPLYPQFSISTSGSS RLLE Sbjct: 84 QLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNLVILPLYPQFSISTSGSSFRLLER 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 +++ED L +++TVIPSWY+ GY++AMA LI +E+ +FP P +V +FFSAHGVP +YV Sbjct: 144 LWQEDPKLQRLEYTVIPSWYKEPGYLQAMAELIRQEIEQFPHPDQVHVFFSAHGVPKSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEELEK 561 EEAGDPY+ E+EEC LIM+ L + Sbjct: 204 EEAGDPYQQEIEECTALIMQTLNR 227
>HEMH_SYNEL (Q8DGU6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 388 Score = 209 bits (531), Expect = 6e-54 Identities = 113/204 (55%), Positives = 141/204 (69%), Gaps = 18/204 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF+DP+IIRLP R+LQKPLA FIS +RA +S+ YA IGGGSPLR+IT+ Q AL + Sbjct: 27 NLFSDPEIIRLP--FRWLQKPLAWFISTSRARRSQANYAQIGGGSPLRRITEQQARALKD 84 Query: 184 ALCGKDIPA------------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 AL G I A +IK D I +LV+LPLYPQFSISTSGSS RLLES Sbjct: 85 ALEGIGIEANLYIGMRYWHPFTEEAIAQIKADQIRELVILPLYPQFSISTSGSSFRLLES 144 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 ++ +D L +++T+IPSWY GY+ AMA LI +EL + P P + +IFFSAHGVP +YV Sbjct: 145 LWNQDPELQKIRYTLIPSWYNHPGYVAAMADLIRQELDRCPNPDEAVIFFSAHGVPKSYV 204 Query: 490 EEAGDPYKAEMEECVDLIMEELEK 561 EAGDPY+ E+E CV LIM L + Sbjct: 205 TEAGDPYQEEIEACVRLIMAALNR 228
>HEMH_SYNY3 (P54225) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 387 Score = 201 bits (510), Expect = 2e-51 Identities = 110/204 (53%), Positives = 135/204 (66%), Gaps = 18/204 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADP+IIRLP +LQKPLA IS RA KS+ YA IGGGSPL QIT+AQ AL Sbjct: 26 NLFADPEIIRLP--FPWLQKPLAWLISTLRAKKSQANYAEIGGGSPLLQITEAQASALTT 83 Query: 184 AL--CGKDIPA----------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L G+D KIK D + +LV+LPLYP FSISTSGSS R+LE Sbjct: 84 RLERLGQDAKVYIGMRYWHPFTEEAVEKIKGDRLQRLVILPLYPHFSISTSGSSFRVLEE 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 ++ D L + +++IPSWY GY++AMA LI +EL KFP P + IFFSAHGVP +YV Sbjct: 144 MWHNDPSLRQLDYSLIPSWYDHPGYLQAMADLIAQELKKFPNPDQAHIFFSAHGVPQSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEELEK 561 +EAGDPY+AE+E C LIM L++ Sbjct: 204 DEAGDPYQAEIEACTRLIMRTLDR 227
>HEMH_SYNP6 (Q5N2B2) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 387 Score = 199 bits (505), Expect = 6e-51 Identities = 110/212 (51%), Positives = 140/212 (66%), Gaps = 18/212 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADP+IIRLP +LQKPLA IS R KS+E Y IGGGSPLR+IT+ Q AL + Sbjct: 26 NLFADPEIIRLP--FPWLQKPLAWLISSLRTRKSQENYKQIGGGSPLRRITEEQATALRQ 83 Query: 184 ALCGK------------------DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +L + + A+IK DGI +LV+LPLYPQFSISTSGSS RLL+ Sbjct: 84 SLSDRGQAAQVYIGMRYWHPFTEEAIAQIKADGIDRLVILPLYPQFSISTSGSSFRLLQR 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + D + +V+PSWY+R GY++AMA LI +EL K +P++ +FFSAHGVP++YV Sbjct: 144 LRDRDPEFQKIDCSVVPSWYERSGYLQAMAELIAQELDKLEQPEQGHVFFSAHGVPVSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 EEAGDPY+ E+E+C IME L G NP T Sbjct: 204 EEAGDPYQREIEDCTRKIMETL---GRSNPWT 232
>HEMH_GLOVI (Q7NMC7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 327 Score = 187 bits (476), Expect = 1e-47 Identities = 105/202 (51%), Positives = 130/202 (64%), Gaps = 18/202 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADP+IIR+P + LQKPLA IS RAPKS++ Y +IGGGSPLR IT+ QG L + Sbjct: 26 NLFADPEIIRIP--VPPLQKPLAWLISTLRAPKSRKNYQAIGGGSPLRAITNQQGRVLKK 83 Query: 184 ALC--GKDIPA----------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 AL G DI KIK DGI +LV+LPLYPQ+SISTSGSS +LL+ Sbjct: 84 ALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRLVLLPLYPQYSISTSGSSFKLLDQ 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 I+ D L ++ I SWY R GYI+AM + + L KF P V I FSAHGVP YV Sbjct: 144 IWARDPSLKAIERITINSWYSRPGYIRAMGERVREGLDKFDNPDGVHILFSAHGVPRTYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEEL 555 ++ GDPY+ + EE VDL+M+ L Sbjct: 204 DQDGDPYQRQTEETVDLVMQSL 225
>HEMH_SYNPX (Q7U5G0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 391 Score = 182 bits (461), Expect = 8e-46 Identities = 105/213 (49%), Positives = 130/213 (61%), Gaps = 19/213 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLFADP+IIRLP LQKPLA IS R+ KS+E Y SIGGGSPLR+IT+ Q L Sbjct: 26 NLFADPEIIRLPSPA--LQKPLAWLISTLRSGKSQEAYRSIGGGSPLRRITEQQARELQS 83 Query: 184 ALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L + + A +K DG+ ++VVLPLYP FSISTSGSS R L+ Sbjct: 84 LLRQRGLDATTYVAMRYWHPFTESAVADMKADGMDEVVVLPLYPHFSISTSGSSFRELQR 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + + D + I SW+ GYIKAMA LI +E+ P+K +FFSAHGVP +YV Sbjct: 144 LRQGDAAFEQLPIRCIRSWFDHPGYIKAMAELIAEEVRNSDDPEKAHVFFSAHGVPKSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEEL-EKRGMENPCT 585 EEAGDPY+ ++E C DLIM+ L E G NP T Sbjct: 204 EEAGDPYQQQIEACTDLIMKSLAEHMGHSNPHT 236
>HEMH_PROMM (Q7V6C6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 391 Score = 179 bits (454), Expect = 5e-45 Identities = 102/211 (48%), Positives = 129/211 (61%), Gaps = 19/211 (9%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 N+FADP+IIRLP LQ+PLA IS R+ KS++ Y SIGGGSPLR+IT+ Q L Sbjct: 26 NIFADPEIIRLPNPA--LQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQARELQS 83 Query: 184 ALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L + I A IK DGI ++VVLPLYP FSISTSGSS R L+ Sbjct: 84 LLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQR 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + + DE + I SWY GY++AMA LI +++ P++ +FFSAHGVP +YV Sbjct: 144 LRQTDESFRKLPIRCIRSWYDHPGYVRAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEELEK-RGMENP 579 E+AGDPY+ E+E C LIM ELE G NP Sbjct: 204 EQAGDPYQKEIEACTTLIMAELENLLGYGNP 234
>HEMH_PROMA (Q7VD58) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 391 Score = 174 bits (441), Expect = 2e-43 Identities = 101/213 (47%), Positives = 128/213 (60%), Gaps = 19/213 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF+DP+IIRLP L QKPLA FIS R+ KS++ Y +IGGGSPLR+IT+ Q L Sbjct: 26 NLFSDPEIIRLP--LPIFQKPLAWFISTLRSSKSQKAYQAIGGGSPLRRITEQQARELQS 83 Query: 184 ALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 AL + I A IK D I ++VVLPLYP FSISTSGSS R L Sbjct: 84 ALRNRGINATSYVAMRYWHPFTESAVEDIKADNINEVVVLPLYPHFSISTSGSSFRELRR 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + D+ + I SW+ GYI +MA LIE+E+ P I F+AHGVP +YV Sbjct: 144 LREVDKEFQKLSIRCIRSWFDNTGYIASMAELIEQEISSCESPNAAHICFTAHGVPKSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEELEKR-GMENPCT 585 EEAGDPYK E+++C LI++++EK G N T Sbjct: 204 EEAGDPYKDEIQDCALLIIDKVEKSLGFSNSYT 236
>HEMH_PROMP (Q7V2F5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 391 Score = 171 bits (433), Expect = 1e-42 Identities = 96/213 (45%), Positives = 128/213 (60%), Gaps = 19/213 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF+DP+IIRLP + QKPLA IS R+ S++ Y SIGGGSP+R+IT+ Q L Sbjct: 26 NLFSDPEIIRLP--VPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARELQS 83 Query: 184 ALCGKDIP------------------AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L K + A +K DG+ ++VVLPLYP FSISTSGSS R L+ Sbjct: 84 KLRDKGLNVTTYIAMRYWHPFTESAIADMKADGVDQIVVLPLYPHFSISTSGSSFRELKK 143 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + D + + SW+ + GY+K+M LI +++ P IFF+AHGVP +YV Sbjct: 144 LRDSDSEFQKIPMRCVRSWFSQSGYLKSMVELISEQISLCESPDSAHIFFTAHGVPKSYV 203 Query: 490 EEAGDPYKAEMEECVDLIMEELEK-RGMENPCT 585 EEAGDPYK ++E+C LI++ELEK G NP T Sbjct: 204 EEAGDPYKEQIEDCSLLIIDELEKYLGHTNPYT 236
>HEMH_DESPS (Q6APB0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 124 bits (312), Expect = 2e-28 Identities = 82/206 (39%), Positives = 116/206 (56%), Gaps = 18/206 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF+D +II P R +QKPLA I+ RAPKS Y IGGGSPL+QIT+AQ EAL + Sbjct: 28 NLFSDREII--PLGPRLMQKPLAWLIAKRRAPKSAATYERIGGGSPLKQITEAQAEALEK 85 Query: 184 AL------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +L C + + + K G+ +LV L LYP +S +T+GSSL L Sbjct: 86 SLQAHGNFTVTYAMRYWPPYCDEALDYLLSK-GVERLVALSLYPHYSKATTGSSLTQLHK 144 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 ++ +++ T IPSW ++ YI A+A I+K L F +K I +SAH +P +++ Sbjct: 145 TLKKKN--ISLPLTEIPSWPKQRDYIAAIAANIKKGLATF-HGEKTEIVYSAHSLPTSFI 201 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRG 567 EAGDPY ++ + I E KRG Sbjct: 202 -EAGDPYVEHTKQSIGAIEEITGKRG 226
>HEMH_XENLA (O57478) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 411 Score = 109 bits (272), Expect = 7e-24 Identities = 75/216 (34%), Positives = 108/216 (50%), Gaps = 23/216 (10%) Frame = +1 Query: 1 VNLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA-- 174 + LF D D++ LP Q LA FI+ R PK +E Y+ IGGGSP+++ T+ QGE Sbjct: 77 LRLFLDKDLMTLPA-----QSKLAPFIAKRRTPKIQEQYSKIGGGSPIKKWTEQQGEGMV 131 Query: 175 -LMEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLR 297 L++ L P K +++DG+ + + YPQ+S ST+GSSL Sbjct: 132 KLLDELSPATAPHKYYIGFRYVRPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLN 191 Query: 298 LLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHG 471 + + M+ +VI W I+ A I+KEL FP K +V+I FSAH Sbjct: 192 AIYRYYNAKGTQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGEVVILFSAHS 251 Query: 472 VPLAYVEEAGDPYKAEMEECVDLIMEELEKRGMENP 579 +P++ V GDPY E+ V +ME L G NP Sbjct: 252 LPMSVVNR-GDPYPQEVGATVQKVMERL---GFSNP 283
>HEMH_GEOSL (Q747F5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 317 Score = 108 bits (271), Expect = 9e-24 Identities = 68/201 (33%), Positives = 111/201 (55%), Gaps = 15/201 (7%) Frame = +1 Query: 1 VNLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALM 180 +NLF+D DIIR+ A FLQ +A+ I+ R+P + Y IGG SP+R++T++Q AL Sbjct: 26 LNLFSDRDIIRIGPA--FLQPFIARLIAKRRSPGVERKYEEIGGKSPIRELTESQARALE 83 Query: 181 EAL---------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIF 315 + L + A I+++GI++++ L LYP +S +T+GSS+ L+ + Sbjct: 84 DVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIALSLYPHYSRATTGSSVNELKRVL 143 Query: 316 REDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 + V Q + ++ YI A+A I + L F +V + FSAH +P ++++E Sbjct: 144 SQSG--VQFQMMYVDRFFDHPLYIDALAEKIREGLDDFHPLAEVQVLFSAHSLPQSFIDE 201 Query: 496 AGDPYKAEMEECVDLIMEELE 558 GDPY + E V L+ME E Sbjct: 202 -GDPYLDHIRETVRLVMERFE 221
>HEMH_PANTR (Q3YA36) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 423 Score = 105 bits (261), Expect = 1e-22 Identities = 72/209 (34%), Positives = 103/209 (49%), Gaps = 23/209 (11%) Frame = +1 Query: 1 VNLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA-- 174 + LF D D++ LP +Q LA FI+ R PK +E Y IGGGSP++ T QGE Sbjct: 90 LRLFLDRDLMTLP-----IQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMV 144 Query: 175 -LMEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLR 297 L++ L P K +++DG+ + + YPQ+S ST+GSSL Sbjct: 145 KLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLN 204 Query: 298 LLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHG 471 + + + M+ + I W I+ A I KEL FP K +V+I FSAH Sbjct: 205 AIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHS 264 Query: 472 VPLAYVEEAGDPYKAEMEECVDLIMEELE 558 +P++ V GDPY E+ V +ME LE Sbjct: 265 LPMSVVNR-GDPYPQEVSATVQKVMERLE 292
>HEMH_HUMAN (P22830) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 423 Score = 105 bits (261), Expect = 1e-22 Identities = 72/209 (34%), Positives = 103/209 (49%), Gaps = 23/209 (11%) Frame = +1 Query: 1 VNLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA-- 174 + LF D D++ LP +Q LA FI+ R PK +E Y IGGGSP++ T QGE Sbjct: 90 LRLFLDRDLMTLP-----IQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMV 144 Query: 175 -LMEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLR 297 L++ L P K +++DG+ + + YPQ+S ST+GSSL Sbjct: 145 KLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLN 204 Query: 298 LLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHG 471 + + + M+ + I W I+ A I KEL FP K +V+I FSAH Sbjct: 205 AIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHS 264 Query: 472 VPLAYVEEAGDPYKAEMEECVDLIMEELE 558 +P++ V GDPY E+ V +ME LE Sbjct: 265 LPMSVVNR-GDPYPQEVSATVQKVMERLE 292
>HEMH_CHICK (O42479) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 402 Score = 104 bits (260), Expect = 2e-22 Identities = 70/208 (33%), Positives = 107/208 (51%), Gaps = 23/208 (11%) Frame = +1 Query: 1 VNLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA-- 174 + LF D D++ LP Q LA FI+ R P+ +E Y+ IGGGSP+++ T QGE Sbjct: 69 LRLFLDRDLMTLPA-----QNKLAPFIAKRRTPRIQEQYSRIGGGSPIKKWTAVQGEGMV 123 Query: 175 -LMEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLR 297 L++++ + P K ++ DGI + + YPQ+S ST+GSSL Sbjct: 124 KLLDSMSPQTAPHKYYIGFRYVHPLTEEAIEEMEDDGIERAIAFTQYPQYSCSTTGSSLN 183 Query: 298 LLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHG 471 + + + M+ ++I W I+ A I+KEL FP K + V+I FSAH Sbjct: 184 AIYRYYNKKGKKPKMKWSIIDRWPTHPLLIQCFADHIQKELDLFPPDKRKDVVILFSAHS 243 Query: 472 VPLAYVEEAGDPYKAEMEECVDLIMEEL 555 +P++ V GDPY E+ V +ME+L Sbjct: 244 LPMSVVNR-GDPYPQEVGATVQRVMEKL 270
>HEMH_YEAST (P16622) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 393 Score = 103 bits (257), Expect = 4e-22 Identities = 72/207 (34%), Positives = 111/207 (53%), Gaps = 23/207 (11%) Frame = +1 Query: 7 LFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGE---AL 177 LFAD D+I P + ++ QK +A++I+ R PK ++ Y IGGGSP+R+ ++ Q + Sbjct: 62 LFADNDLI--PISAKY-QKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKI 118 Query: 178 MEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLL 303 ++ C + P K + KDG+ K V YP FS ST+GSS+ L Sbjct: 119 LDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINEL 178 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKP--QKVMIFFSAHGVP 477 + + ++ +VI W EG IKA + I K+L +FP+P KV++ FSAH +P Sbjct: 179 WRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLP 238 Query: 478 LAYVEEAGDPYKAEMEECVDLIMEELE 558 + V GD Y AE+ V IM++L+ Sbjct: 239 MDVV-NTGDAYPAEVAATVYNIMQKLK 264
>HEMH_BOVIN (P22600) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 416 Score = 103 bits (256), Expect = 5e-22 Identities = 74/214 (34%), Positives = 105/214 (49%), Gaps = 23/214 (10%) Frame = +1 Query: 7 LFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA---L 177 LF D D++ LP +Q L FI+ R PK +E Y IGGGSP++ T QGE L Sbjct: 85 LFLDQDLMTLP-----VQDKLGPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKL 139 Query: 178 MEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLL 303 ++ L P K +++DG+ + V YPQ+S ST+GSSL + Sbjct: 140 LDELSPHTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAVAFTQYPQYSCSTTGSSLNAI 199 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHGVP 477 + E M+ + I W I+ A I KEL FP K ++V+I FSAH +P Sbjct: 200 YRYYNEVGRKPTMKWSTIDRWPTHPLLIQCFADHILKELDHFPPEKRREVVILFSAHSLP 259 Query: 478 LAYVEEAGDPYKAEMEECVDLIMEELEKRGMENP 579 ++ V GDPY E+ V +M++L G NP Sbjct: 260 MSVVNR-GDPYPQEVGATVQRVMDKL---GYSNP 289
>HEMH_AQUAE (O67083) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 309 Score = 102 bits (254), Expect = 8e-22 Identities = 73/200 (36%), Positives = 105/200 (52%), Gaps = 18/200 (9%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF+DPDI LP QK LA+ I+ RA K++ Y +GG SP + T Q +AL E Sbjct: 25 NLFSDPDIFSLP-----FQKVLAKIIAKLRAKKTRHYYELMGGKSPQYEQTLEQAKALQE 79 Query: 184 ALCG---------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLE---S 309 L KD +++ K+GI ++++LPLYPQ+S +T+GS+ E Sbjct: 80 RLGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYPQYSKTTTGSAFNEFERSKK 139 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + D V I +Y YIKA A I++ + KP++ FSAH +P + Sbjct: 140 ALKADHIKVKK----IEHFYDHPLYIKAWAEQIKQSV---EKPEEYHFLFSAHSLPKKLI 192 Query: 490 EEAGDPYKAEMEECVDLIME 549 EE GDPY+ + E+ V LIME Sbjct: 193 EE-GDPYQEQTEKTVKLIME 211
>HEMH_MOUSE (P22315) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 420 Score = 98.6 bits (244), Expect = 1e-20 Identities = 74/214 (34%), Positives = 104/214 (48%), Gaps = 23/214 (10%) Frame = +1 Query: 7 LFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA---L 177 LF D D++ LP +Q LA FI+ R PK +E IGGGSP++ T QGE L Sbjct: 91 LFLDRDLMTLP-----IQNKLAPFIAKRRTPKIQE--RRIGGGSPIKMWTSKQGEGMVKL 143 Query: 178 MEALCGKDIPAK------------------IKKDGITKLVVLPLYPQFSISTSGSSLRLL 303 ++ L P K +++DG+ + + YPQ+S ST+GSSL + Sbjct: 144 LDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAI 203 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHGVP 477 + E M+ + I W I+ A I KEL FP K +V+I FSAH +P Sbjct: 204 YRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLP 263 Query: 478 LAYVEEAGDPYKAEMEECVDLIMEELEKRGMENP 579 ++ V GDPY E+ V +ME+L G NP Sbjct: 264 MSVVNR-GDPYPQEVGATVHKVMEKL---GYPNP 293
>HEMH_DROME (Q9V9S8) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 384 Score = 94.7 bits (234), Expect = 2e-19 Identities = 67/216 (31%), Positives = 108/216 (50%), Gaps = 23/216 (10%) Frame = +1 Query: 1 VNLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALM 180 + + D D+I+LP +Q L +I+ R P+ ++ Y IGGGSP+ + T+ QG+ + Sbjct: 50 LRIMTDRDMIQLP-----VQSRLGPWIAQRRTPEVQKKYKEIGGGSPILKWTELQGQLMC 104 Query: 181 EAL---------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLR 297 E L ++ A+I+KD ++V+ YPQ+S +TSGSS Sbjct: 105 EQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQYSCATSGSSFN 164 Query: 298 LLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKF--PKPQKVMIFFSAHG 471 + + +R + +++ ++I W IK A I EL KF K V+I F+AH Sbjct: 165 SIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVILFTAHS 224 Query: 472 VPLAYVEEAGDPYKAEMEECVDLIMEELEKRGMENP 579 +PL V GD Y +E+ V ++M+EL G NP Sbjct: 225 LPLKAVNR-GDAYPSEIGASVHMVMQEL---GQTNP 256
>HEMH_RICCN (Q92FV4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 342 Score = 93.6 bits (231), Expect = 4e-19 Identities = 70/214 (32%), Positives = 116/214 (54%), Gaps = 20/214 (9%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF D II LP LR++ +A+ IS+ R KS++ Y+ IGG S L Q T+ Q AL E Sbjct: 27 NLFYDKAIINLPNPLRYI---IAKIISITREKKSQKIYSLIGGKSSLLQETEEQKLALTE 83 Query: 184 AL-------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLR-LL 303 L K++ +IKK +++++LPLY QFS +T+GSS++ L Sbjct: 84 KLKQLIKEDFAIFINMRYSAPFAKEVIGQIKKYNPSEIILLPLYSQFSSTTTGSSVKNFL 143 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLA 483 +++ +++ I + + +IKA +LI+++L + I FSAHG+P Sbjct: 144 QNLD------IDIPIKTICCYPLEKDFIKAHVSLIKEKLY----DKNFRILFSAHGLPEK 193 Query: 484 YVEEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 + +AGDPY +++E V I++EL + ++ T Sbjct: 194 II-KAGDPYSFQIKETVQAIVKELNIKDLDYKIT 226
>HEMH_SCHPO (O59786) Ferrochelatase, mitochondrial precursor (EC 4.99.1.1)| (Protoheme ferro-lyase) (Heme synthetase) Length = 384 Score = 93.2 bits (230), Expect = 5e-19 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 23/206 (11%) Frame = +1 Query: 7 LFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEA 186 LF D DII L + Q L +FI+ R PK + Y+ IGGGSP+ T QG + + Sbjct: 56 LFTDGDII----PLGYFQNSLGKFIAKRRTPKVQNHYSDIGGGSPILHWTRIQGSEMCKI 111 Query: 187 LCGK---------------------DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLL 303 L K D+ ++KK +++ V YPQ+S +TSG+SL L Sbjct: 112 LDKKCPESAPHLPFVAFRYAPPLTEDMLDELKKANVSRAVAFSQYPQWSCATSGASLNEL 171 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQK--VMIFFSAHGVP 477 E + + +++ W ++G I A A IE+ L +P+ + V+I FSAH +P Sbjct: 172 RRKLIEKGMEKDFEWSIVDRWPLQQGLINAFAENIEETLKTYPEDVRDDVVIVFSAHSLP 231 Query: 478 LAYVEEAGDPYKAEMEECVDLIMEEL 555 ++ V + GDPY E+ +M+ L Sbjct: 232 MSQVAK-GDPYVYEIAATSQAVMKRL 256
>HEMH_CAUCR (P57777) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 347 Score = 92.4 bits (228), Expect = 8e-19 Identities = 66/194 (34%), Positives = 95/194 (48%), Gaps = 20/194 (10%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEAL-- 177 NLF DP II P +R+ PLA IS R +K YA +GGGSPL T+ Q AL Sbjct: 27 NLFRDPAIIGAPALIRY---PLAALISTTREKSAKANYAIMGGGSPLLPETEKQARALEA 83 Query: 178 --------MEALC----------GKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLL 303 +EA C + ++ ++V+LPLYPQFS +T+GSSL+ Sbjct: 84 ALALAMPGVEAKCFIAMRYWHPLTDETARQVAAFAPDQVVLLPLYPQFSTTTTGSSLKAW 143 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLA 483 + ++ T + + G I+A A +I + K P + + FSAHG+P Sbjct: 144 KKTYKGSGV-----QTTVGCYPTEGGLIEAHARMIRESWEKAGSPTNIRLLFSAHGLP-E 197 Query: 484 YVEEAGDPYKAEME 525 V AGDPY+ ++E Sbjct: 198 KVILAGDPYQKQVE 211
>HEMH_RICPR (Q9ZC84) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 342 Score = 92.4 bits (228), Expect = 8e-19 Identities = 69/214 (32%), Positives = 117/214 (54%), Gaps = 20/214 (9%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF D II LP LR++ +A+ IS+ R KS++ Y+ IG S L Q T+ Q A+ E Sbjct: 27 NLFYDKAIINLPNPLRYI---IAKIISITREKKSQKIYSLIGSKSYLIQETEKQKLAITE 83 Query: 184 AL-------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLR-LL 303 L K++ +IK+ +++++LPLYPQFS +T+GSS++ L Sbjct: 84 KLKEFIKEDFIIFINMRYSTPFAKEVIGQIKEYNPSEIILLPLYPQFSSTTTGSSVKNFL 143 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLA 483 ++I +++ I + E +IKA ++I+++L + I FSAHG+P Sbjct: 144 QNID------IDIPIKTICCYPIEEDFIKAHVSIIKEKLY----DKNFRILFSAHGLPKR 193 Query: 484 YVEEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 + +AGDPY +++E V+ I++EL + ++ T Sbjct: 194 II-KAGDPYSFQIKETVNKIVKELNIKDLDYKIT 226
>HEMH_RICTY (Q68VM9) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 342 Score = 89.4 bits (220), Expect = 7e-18 Identities = 68/214 (31%), Positives = 117/214 (54%), Gaps = 20/214 (9%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF D II LP LR++ +A+ IS+ R KS++ Y+ IG S L Q T+ Q A+ + Sbjct: 27 NLFYDKAIINLPNPLRYV---IAKIISIVRERKSQKIYSLIGRKSYLIQETEKQKLAITK 83 Query: 184 AL-------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLR-LL 303 L K++ +IK+ +++++LPLYPQFS +T+GSS++ L Sbjct: 84 KLKEILKEDFIIFISMRYSTPFAKEVICQIKEYNPSEIILLPLYPQFSSTTTGSSVKNFL 143 Query: 304 ESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLA 483 ++I +++ I + E +IKA ++I+++L + I FSAHG+P Sbjct: 144 QNID------IDIPIKTICCYPIEEDFIKAHVSIIKEKLY----DKNFRILFSAHGLPKR 193 Query: 484 YVEEAGDPYKAEMEECVDLIMEELEKRGMENPCT 585 + +AGDPY +++E V+ I++EL + ++ T Sbjct: 194 II-KAGDPYSFQIKETVNKIVKELNIKDLDYKIT 226
>HEMH_WOLPM (Q73FY6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 315 Score = 89.0 bits (219), Expect = 9e-18 Identities = 64/203 (31%), Positives = 101/203 (49%), Gaps = 19/203 (9%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 NLF D II LP RFL LA+FIS R +++ Y IGG SP+ + T Q A Sbjct: 25 NLFYDRRIINLPNPFRFL---LAKFISAKRENTARKIYEEIGGKSPILENTKMQANASEL 81 Query: 184 AL-------------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLE 306 L ++ +K+ ++++LPLYPQ+S +T+ SS+ + Sbjct: 82 KLNENRNHVHKVFICMRYWRPFADEVIESVKQFDPDEVILLPLYPQYSTTTTLSSIENWQ 141 Query: 307 SIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAY 486 Y + +I +Y + +I+A LI K K K + FSAH +PL+ Sbjct: 142 K--NAKRYGLKCNTKMIHRYYDNQDFIEAHTNLIAKYYKLARKIGKPRVLFSAHSLPLSI 199 Query: 487 VEEAGDPYKAEMEECVDLIMEEL 555 +++ GDPY +++E V+LI+E+L Sbjct: 200 IKK-GDPYASQVERSVELIVEKL 221
>HEMH_HELHP (Q7VHH1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 311 Score = 85.5 bits (210), Expect = 1e-16 Identities = 64/203 (31%), Positives = 100/203 (49%), Gaps = 14/203 (6%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 N+F DP I+ + F +K LA FI+ +R ++K+ Y +IGG SPL T L E Sbjct: 16 NMFNDPLILGIKNT--FARKMLASFITHSRVEETKKNYQAIGGKSPLTAHTLNLTNKLNE 73 Query: 184 ALCGK--------------DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 C + + IK GI +V+ LYPQFS ST SSL ++ ++ Sbjct: 74 LDCKRFYTYAMRYTPPFAYQVLEDIKTQGIQSVVLFSLYPQFSYSTIASSLIDAKAALQK 133 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAG 501 + + I S++ YI + I KE L P + ++ SAH +P + ++E G Sbjct: 134 LAFTPTLYE--ISSYHTHPDYISCIIERI-KESLGADNPNEFVLLLSAHSLPQSRIDE-G 189 Query: 502 DPYKAEMEECVDLIMEELEKRGM 570 DPY+ + EE ++I + LE G+ Sbjct: 190 DPYQKQCEENKEVIQKALESEGI 212
>HEMH_LEPBI (Q8GCV0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 362 Score = 74.7 bits (182), Expect = 2e-13 Identities = 78/225 (34%), Positives = 110/225 (48%), Gaps = 37/225 (16%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPLRQITDAQGEAL 177 +LF+DP + LP FL+ LA+FI+ RAPK ++ Y S+G GGSPL + T Q AL Sbjct: 29 DLFSDPFVFDLPLP-EFLRLRLARFIAKKRAPKVQKSYESMGFGGGSPLVEETAKQAHAL 87 Query: 178 MEAL---------------CG----KDIP-AKIKKDGITKLVVLPLYPQFSISTSGSSLR 297 AL CG +DI K +D V LPLYPQFS ST S+L Sbjct: 88 ELALNERSSEQWNVKVAMACGYPNMRDIEFGKPNQD----TVYLPLYPQFSRSTVLSTLA 143 Query: 298 LLESIFRE---------DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KP-- 438 +LE+ F E + ++ I + + E + L + + L +P KP Sbjct: 144 ILETKFGECPVGSGGYVPHFGLDPNFHSISAKFIYEFFTN---QLPKDQYLHYPEEKPNC 200 Query: 439 --QKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEELEKRG 567 + + + FSAHGVP+ + + GD Y E+E V I +EL K G Sbjct: 201 DWRNLDLVFSAHGVPMRLIHK-GDRYMEEVELSVKGIADELSKFG 244
>HEMH_IDILO (Q5QVZ8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 364 Score = 74.7 bits (182), Expect = 2e-13 Identities = 66/202 (32%), Positives = 99/202 (49%), Gaps = 21/202 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASI--GGGSPLRQITDAQG---EAL 177 +DP ++ +PR L FL L I R +S E Y ++ GSPL T Q EA Sbjct: 44 SDPRVVEVPRLLWFLI--LNGVILRFRPKRSAEAYKTVWTDRGSPLLFHTQDQASAIEAK 101 Query: 178 MEALCGKDI----------PA------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 ++ G +I PA K+ + G+ KL+VLPLYPQ+S ST+ S+ L Sbjct: 102 LKQTWGDNIVVDFAMRYGNPALSEVVEKMMQKGVRKLLVLPLYPQYSASTTASTFDALAK 161 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 F + +L ++ I ++ +I+A A IEK + K++ FS HG+PL Y+ Sbjct: 162 DFTKRRWLPELR--FITHYHDFSPFIEAAAQRIEKHWDAHGRADKLL--FSYHGIPLRYL 217 Query: 490 EEAGDPYKAEMEECVDLIMEEL 555 + GDPY E + L+ E L Sbjct: 218 KN-GDPYHCECYKTSRLLAERL 238
>HEMH_CHRVO (Q7NV65) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 364 Score = 70.9 bits (172), Expect = 3e-12 Identities = 62/206 (30%), Positives = 99/206 (48%), Gaps = 22/206 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGG--GSPLRQITDAQGEALMEA 186 +DP +I +PR +L L I R +S + YASI GSPL T +Q + L Sbjct: 47 SDPRVIEIPRLPWWLI--LNGIILNTRPKQSAKKYASIWTKEGSPLLLHTRSQAKLLKGQ 104 Query: 187 LCG-------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L + + K+++ G+ +L++LPLYPQ++ S+S ++ L+ Sbjct: 105 LGEMGLHNLAVDYAMRYGNPSIESVIGKMREQGVERLLLLPLYPQYAASSSATA---LDE 161 Query: 310 IFREDEYLVNMQHT-VIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAY 486 FR L NM + ++ GYI A+A I K +P K+++ F HGVP + Sbjct: 162 AFRVLSRLRNMPEVRTVRHFHDDPGYIAALAAQIRKHWQYGQRPDKLVMSF--HGVP-RF 218 Query: 487 VEEAGDPYKAEMEECVDLIMEELEKR 564 + GDPY E ++ L+ E L+ R Sbjct: 219 TRDKGDPYHCECQKTGRLLAEALQLR 244
>HEMH_CAMJE (Q9PI08) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 303 Score = 68.6 bits (166), Expect = 1e-11 Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 14/199 (7%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDA------- 162 N+F DP I+ + RFL+K +A I+ AR +E Y +GG SPL ++T + Sbjct: 24 NMFNDPYILGIKN--RFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLNL 81 Query: 163 -QGEALMEAL------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 Q E + + +I K + ++++ PLYP S +T SSL +L++ + Sbjct: 82 KQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLYPHHSCTTVTSSLEVLQNEISK 141 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAG 501 + + + I +Y+ E Y + + + I L K K ++ FSAH +P + +++ G Sbjct: 142 QK--IQAKVKTIDIFYKNELYNEMIVSHI---LAKKSKFDAKILIFSAHSLPQSIIDK-G 195 Query: 502 DPYKAEMEECVDLIMEELE 558 D Y+ + + V+++ E+L+ Sbjct: 196 DLYEKHVNDHVEILKEKLK 214
>HEMH_STAES (Q8CNS1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 68.2 bits (165), Expect = 2e-11 Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCGKDIPAKIK--------------------KD 225 K+ Y IGG SPL TD Q EAL+EAL + K D Sbjct: 43 KDRYEFIGGLSPLAGTTDRQAEALLEALNKEQDDVNFKLYIGLKHISPYIEEAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GI + V + L P +S + GS + + + DEY + + H I +YQ+ +IK Sbjct: 103 GIKEAVTVVLAPHYSSFSVGSYDQRAQE--KADEYGIQLTH--IKHYYQQPKFIKYWTEK 158 Query: 406 IEKELLKFPKPQ--KVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 I + L + P + + ++ SAH +P +E DPY E+ E +++ +E Sbjct: 159 INETLEQIPNQEHDETVLVVSAHSLPKGLIERNNDPYPHELHETAEILKQE 209
>HEMH_STAEQ (Q5HNA5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 68.2 bits (165), Expect = 2e-11 Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCGKDIPAKIK--------------------KD 225 K+ Y IGG SPL TD Q EAL+EAL + K D Sbjct: 43 KDRYEFIGGLSPLAGTTDRQAEALLEALNKEQDDVNFKLYLGLKHISPYIEEAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GI + V + L P +S + GS + + + DEY + + H I +YQ+ +IK Sbjct: 103 GIKEAVTVVLAPHYSSFSVGSYDQRAQE--KADEYGIQLTH--IKHYYQQPKFIKYWTEK 158 Query: 406 IEKELLKFPKPQ--KVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 I + L + P + + ++ SAH +P +E DPY E+ E +++ +E Sbjct: 159 INETLEQIPNQEHDETVLVVSAHSLPKGLIERNNDPYPHELHETAEILKQE 209
>HEMH_RHOPA (Q6NBF3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 345 Score = 67.8 bits (164), Expect = 2e-11 Identities = 52/159 (32%), Positives = 81/159 (50%), Gaps = 19/159 (11%) Frame = +1 Query: 136 SPLRQITDAQGEALMEALCGKD------------------IPAKIKKDGITKLVVLPLYP 261 SPL+ IT AQ E L +L + I A + K G T+L+V+PLYP Sbjct: 91 SPLKTITRAQAEKLSASLGDRGHLIVDWAMRYGNPSLRDRIEALVAK-GCTRLLVVPLYP 149 Query: 262 QFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP-KP 438 Q+S +TS + + RE ++ V P +Y+ YI A+AT I+ L +P Sbjct: 150 QYSAATSATVCDQAFRVLRELRAQPTLR--VTPPYYRDSAYIDALATSIKSHLASLTFEP 207 Query: 439 QKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + +I S HG+P AY+++ GDPY+A+ V+ + E + Sbjct: 208 E--LIVASFHGMPQAYIDK-GDPYQAQCVATVEALRERM 243
>HEMH_RHILO (Q98H61) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 353 Score = 67.4 bits (163), Expect = 3e-11 Identities = 62/208 (29%), Positives = 97/208 (46%), Gaps = 27/208 (12%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGG----SPLRQITDAQGEALM 180 +DP +I L +A+ + L + R KS YA I SPLR T AQ E L Sbjct: 56 SDPRVIELNKAIWY--PILYGLVLTTRPKKSGANYARIWNQERNESPLRTYTRAQSEKLA 113 Query: 181 EALCGKDIP-------------------AKIKKDGITKLVVLPLYPQFSISTSGSSLRLL 303 EAL D+P ++ G +++ PLYPQ+S +T+ ++ Sbjct: 114 EAL--GDLPDVTVDWAMRYGNPSTASVAERLVAQGCDRILSFPLYPQYSATTTATA---N 168 Query: 304 ESIFREDEYLVNMQHT----VIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHG 471 + +FR L+ ++ +P +Y YI+A+A+ IE+ L +V+I S HG Sbjct: 169 DQLFRA---LMKLRRAPAIRSVPPYYAEPVYIEALASSIERHLATLDFEPEVVI-TSYHG 224 Query: 472 VPLAYVEEAGDPYKAEMEECVDLIMEEL 555 +P Y + GDPY+A E L+ E+L Sbjct: 225 IPKPY-SDKGDPYQAHCLETTRLLREKL 251
>HEMH_HAEIN (P43868) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 323 Score = 67.4 bits (163), Expect = 3e-11 Identities = 59/206 (28%), Positives = 98/206 (47%), Gaps = 21/206 (10%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVA-RAPKSKEGYASIGG--GSPLRQITDAQGEALMEA 186 DP ++ LPR + PL + I + R+ + + Y +I GSPL I+ Q +AL Sbjct: 35 DPRVVDLPRCKWY---PLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAISRQQKDALQAY 91 Query: 187 LCGKDIPAKIK------------------KDGITKLVVLPLYPQFSISTSGSSLRLLESI 312 L ++I +++ K+ + +++VLPLYPQ+S ST+G+ + Sbjct: 92 LDNQNIDTQVEIAMTYGNPSMQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANA 151 Query: 313 FREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVE 492 +E+ L + I S++ E YI A+A I+ L + FS HG+PL Y E Sbjct: 152 LKEERGL--LPFDFIHSYHIDENYINALADSIKVRL-----KSDEFLLFSYHGIPLRY-E 203 Query: 493 EAGDPYKAEMEECVDLIMEELEKRGM 570 + GD Y+ E C + + K G+ Sbjct: 204 KMGDYYR---EHCKQTTIAVVNKLGL 226
>HEMH_BRAJA (P28602) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 345 Score = 66.6 bits (161), Expect = 5e-11 Identities = 55/154 (35%), Positives = 81/154 (52%), Gaps = 21/154 (13%) Frame = +1 Query: 136 SPLRQITDAQGEALMEALCGKD------------------IPAKIKKDGITKLVVLPLYP 261 SPL+ IT +Q + L AL +D I A I +G +++ +PLYP Sbjct: 91 SPLKTITRSQSDKLAAALSDRDHVVVDWAMRYGNPSIKSGIDALIA-EGCDRILAVPLYP 149 Query: 262 QFSISTSGSSLRLLESIFREDEYLVNMQHT--VIPSWYQREGYIKAMATLIEKELLKFP- 432 Q+S STS + + + +FR L Q T V P +Y+ E YI+A+A IE L P Sbjct: 150 QYSASTSAT---VCDEVFRVLARL-RAQPTLRVTPPYYEDEAYIEALAVSIETHLATLPF 205 Query: 433 KPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECV 534 KP+ +I S HG+P +YV++ GDPY+ E C+ Sbjct: 206 KPE--LIVASFHGMPKSYVDK-GDPYQ---EHCI 233
>HEMH_BACSU (P32396) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 310 Score = 65.9 bits (159), Expect = 8e-11 Identities = 58/203 (28%), Positives = 90/203 (44%), Gaps = 23/203 (11%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQG------- 168 + + DI R +R +KP + + K+ Y +IGG SPL QIT+ Q Sbjct: 17 YKEEDIERYYTHIRRGRKPEPEMLQ-----DLKDRYEAIGGISPLAQITEQQAHNLEQHL 71 Query: 169 -----EALMEALCG--------KDIPAKIKKDGITKLVVLPLYPQFS-ISTSGSSLRLLE 306 E +A G +D A++ KDGIT+ V + L P FS S + R E Sbjct: 72 NEIQDEITFKAYIGLKHIEPFIEDAVAEMHKDGITEAVSIVLAPHFSTFSVQSYNKRAKE 131 Query: 307 SIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQK--VMIFFSAHGVPL 480 E E L + T + SWY ++ +++ P+ ++ M+ SAH +P Sbjct: 132 ----EAEKLGGLTITSVESWYDEPKFVTYWVDRVKETYASMPEDERENAMLIVSAHSLP- 186 Query: 481 AYVEEAGDPYKAEMEECVDLIME 549 ++E GDPY ++ E LI E Sbjct: 187 EKIKEFGDPYPDQLHESAKLIAE 209
>HEMH_NEIMB (Q9K097) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 336 Score = 65.5 bits (158), Expect = 1e-10 Identities = 55/202 (27%), Positives = 92/202 (45%), Gaps = 17/202 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPLRQITDAQGEAL 177 + D ++ LP+ L + L + R KS Y I GSPL T Q AL Sbjct: 42 SFLTDRRVVELPKWLWY--PILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQAAAL 99 Query: 178 MEALCG--------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSL-RLLESI 312 + + D+ +++K G +L+V+P+YPQ++ S+SG+++ ++ E + Sbjct: 100 AKRMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLVIPMYPQYAASSSGAAVDKVCEQL 159 Query: 313 FREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVE 492 + M + +Y GYI AM I + + + +K+M+ F HGVP + Sbjct: 160 LLQRN---QMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSF--HGVPQKH-H 213 Query: 493 EAGDPYKAEMEECVDLIMEELE 558 + GDPY E L+ E LE Sbjct: 214 DLGDPYPDECRHTAKLLAEALE 235
>HEMH_BACSK (Q5WHT1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 312 Score = 65.5 bits (158), Expect = 1e-10 Identities = 50/169 (29%), Positives = 73/169 (43%), Gaps = 21/169 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCGK--------------------DIPAKIKKD 225 +E Y +IGG SPL +ITD Q L L + D K+K D Sbjct: 44 QERYEAIGGTSPLARITDEQANGLAAVLNEQQEDIVFVPYLGLKHIDPFIEDAVQKMKND 103 Query: 226 GITKLVVLPLYPQFS-ISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMAT 402 GI V + L P FS S + R E E + + I SWY+ G+++ Sbjct: 104 GIETAVSIVLAPHFSTFSVQSYNKRAQE----EADRIGGPTIYTIESWYKEPGFLQFWKE 159 Query: 403 LIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIME 549 IE E+ K + + FSAH +P + +A DPY ++ E DL+ + Sbjct: 160 QIENEMKKADSIDDLCVIFSAHSLPEKII-QANDPYPEQLRETADLLAD 207
>HEMH_NEIMA (Q9JVA5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 336 Score = 65.1 bits (157), Expect = 1e-10 Identities = 55/202 (27%), Positives = 92/202 (45%), Gaps = 17/202 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPLRQITDAQGEAL 177 + D ++ LP+ L + L + R KS Y I GSPL T Q AL Sbjct: 42 SFLTDRRVVELPKWLWY--PILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQAAAL 99 Query: 178 MEALCG--------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSL-RLLESI 312 + + D+ +++K G +L+V+P+YPQ++ S+SG+++ ++ E + Sbjct: 100 AKRMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLVIPMYPQYAASSSGAAVDKVCEQL 159 Query: 313 FREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVE 492 + M + +Y GYI AM I + + + +K+M+ F HGVP + Sbjct: 160 LLQRN---QMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSF--HGVPQKHY- 213 Query: 493 EAGDPYKAEMEECVDLIMEELE 558 + GDPY E L+ E LE Sbjct: 214 DLGDPYPDECRHTAKLLAEALE 235
>HEMH_BRUSU (P0A3D7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 352 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 19/159 (11%) Frame = +1 Query: 136 SPLRQITDAQGEALMEALCGK-----------------DIPAKIKKDGITKLVVLPLYPQ 264 SPLR T AQGE L +AL + I ++ + G ++V+ PLYPQ Sbjct: 98 SPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQ 157 Query: 265 FSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKEL--LKFPKP 438 +S +T+ + + ++ ++ +PS+ YI A+A +EK L L F KP Sbjct: 158 YSATTTATVNDKFFEALMKKRFMPAIR--TVPSYEAEPVYIDALARSVEKHLATLSF-KP 214 Query: 439 QKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + +I S HG+P +Y + GDPY+ + E L+ E L Sbjct: 215 E--VILTSYHGIPKSY-SDKGDPYRQQCLETTRLLRERL 250
>HEMH_BRUME (P0A3D6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 352 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 19/159 (11%) Frame = +1 Query: 136 SPLRQITDAQGEALMEALCGK-----------------DIPAKIKKDGITKLVVLPLYPQ 264 SPLR T AQGE L +AL + I ++ + G ++V+ PLYPQ Sbjct: 98 SPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQ 157 Query: 265 FSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKEL--LKFPKP 438 +S +T+ + + ++ ++ +PS+ YI A+A +EK L L F KP Sbjct: 158 YSATTTATVNDKFFEALMKKRFMPAIR--TVPSYEAEPVYIDALARSVEKHLATLSF-KP 214 Query: 439 QKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + +I S HG+P +Y + GDPY+ + E L+ E L Sbjct: 215 E--VILTSYHGIPKSY-SDKGDPYRQQCLETTRLLRERL 250
>HEMH_BRUAB (P0A3D8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 352 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 19/159 (11%) Frame = +1 Query: 136 SPLRQITDAQGEALMEALCGK-----------------DIPAKIKKDGITKLVVLPLYPQ 264 SPLR T AQGE L +AL + I ++ + G ++V+ PLYPQ Sbjct: 98 SPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQ 157 Query: 265 FSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKEL--LKFPKP 438 +S +T+ + + ++ ++ +PS+ YI A+A +EK L L F KP Sbjct: 158 YSATTTATVNDKFFEALMKKRFMPAIR--TVPSYEAEPVYIDALARSVEKHLATLSF-KP 214 Query: 439 QKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + +I S HG+P +Y + GDPY+ + E L+ E L Sbjct: 215 E--VILTSYHGIPKSY-SDKGDPYRQQCLETTRLLRERL 250
>HEMH_PASMU (P57874) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 326 Score = 64.7 bits (156), Expect = 2e-10 Identities = 61/211 (28%), Positives = 96/211 (45%), Gaps = 26/211 (12%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVA-RAPKSKEGYASIGG--GSPLRQITDAQGEALMEA 186 DP ++ LPR F PL + I + RA + + YASI GSPL IT Q AL Sbjct: 34 DPRVVDLPRYKWF---PLLKGIILPLRAKRVAKNYASIWTEQGSPLLTITREQQHALQTY 90 Query: 187 LCG------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESI 312 K ++ + L+V PLYPQ+S ST+G ++ Sbjct: 91 FKQQEKNIVVEVAMTYGEPSIKSAMQRLSTQQVDNLIVFPLYPQYSSSTTG-------AV 143 Query: 313 FREDEYLVNMQHTVIP-----SWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVP 477 F ++ Q V+P S++ E YI A+ T I++ +P + ++ FS HG+P Sbjct: 144 FDAFAQVLKTQRGVLPFDFIHSYHTNEDYIAALVTTIQEHF----QPDEFLL-FSFHGIP 198 Query: 478 LAYVEEAGDPYKAEMEECVDLIMEELEKRGM 570 + Y E GD Y+ E C ++ +++ G+ Sbjct: 199 VRY-ENMGDYYR---EHCKQTVLAVIDRLGL 225
>HEMH2_SHEON (Q8EBZ7) Ferrochelatase 2 (EC 4.99.1.1) (Protoheme ferro-lyase 2)| (Heme synthetase 2) Length = 327 Score = 64.3 bits (155), Expect = 2e-10 Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 20/201 (9%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPLRQITDAQGEALMEA 186 +DP ++ +P+ L L L + R KS Y + GSPL I+ Q L + Sbjct: 36 SDPRVVEIPKLLWMLI--LYGIVLRVRPAKSAALYQKVWTEAGSPLMDISLRQTAKLSDK 93 Query: 187 LC--GKDIPA----------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESI 312 L G + ++ K GI KLVVLPLYPQ++ T+GS+ + Sbjct: 94 LTADGHQVSVHLAMRYGNPSVASTLREMHKQGIDKLVVLPLYPQYAAPTTGSAFDAIAKE 153 Query: 313 FREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVE 492 + YL ++ I +++ +I A+ I + K KPQK+++ S HG+P + Sbjct: 154 LSQWRYLPSLH--FINTYHDNPDFIAALVNSIRDDFDKHGKPQKLVL--SYHGMPERNL- 208 Query: 493 EAGDPYKAEMEECVDLIMEEL 555 GDPY + L+ E+L Sbjct: 209 HLGDPYYCFCMKTTRLVAEQL 229
>HEMH_WOLSU (Q7M7P9) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 316 Score = 64.3 bits (155), Expect = 2e-10 Identities = 58/204 (28%), Positives = 98/204 (48%), Gaps = 15/204 (7%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 N+F DP I LP F + +A FI+ R+ +K Y IGG SPL T + L Sbjct: 25 NMFNDPRI--LPIKSPFFRSLVASFIANRRSETAKANYRKIGGKSPLIGHTFNLIQKLQS 82 Query: 184 ALCGK-------------DIPAK-IKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 + D+ + + + I ++ + LYPQ+S +T+ SS+ E ++ Sbjct: 83 LDPSRFYTYAMRYTPPMTDMAVRELAQKEIEEVTLFSLYPQYSTTTTLSSI---EEFHKQ 139 Query: 322 DEYLVNMQHTV-IPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEA 498 L T I +++ Y +A+ I E L P++ + FSAHG+P + ++ A Sbjct: 140 CALLSYFPKTKEIDRYFEDSNYNEAIIDRI-LEALGGDNPEEFTLIFSAHGLPQSVID-A 197 Query: 499 GDPYKAEMEECVDLIMEELEKRGM 570 GDPY+ E+ + + + LE+RG+ Sbjct: 198 GDPYEKEVHANIQALTKLLEERGI 221
>HEMH1_SHEON (Q8EFF4) Ferrochelatase 1 (EC 4.99.1.1) (Protoheme ferro-lyase 1)| (Heme synthetase 1) Length = 348 Score = 63.5 bits (153), Expect = 4e-10 Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 22/203 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKS-KEGYASIGG--GSPLRQITDAQGEAL-- 177 +DP ++ L +L +P+ Q I + PK + Y S+ GSPL I+ Q + L Sbjct: 49 SDPRVVDLSP---WLWQPILQGIILNTRPKKVAKLYQSVWTEQGSPLMVISQCQAQKLAT 105 Query: 178 -MEALCGKDIP----------------AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLE 306 + A + IP AK+K G ++VVLPLYPQ+S ST S + Sbjct: 106 DLSATFNQTIPVELGMSYGNPSIESGFAKLKAQGAERIVVLPLYPQYSCSTVASVFDAVA 165 Query: 307 SIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAY 486 + ++ ++ E YI A+A +++ + +K+++ F HG+PL Y Sbjct: 166 HYLTRVRDIPELRFN--KQYFAHEAYIAALAHSVKRHWKTHGQAEKLILSF--HGIPLRY 221 Query: 487 VEEAGDPYKAEMEECVDLIMEEL 555 E GDPY + L+ + L Sbjct: 222 ATE-GDPYPEQCRTTAKLLAQAL 243
>HEMH_LACPL (Q88XC3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 324 Score = 63.5 bits (153), Expect = 4e-10 Identities = 59/196 (30%), Positives = 86/196 (43%), Gaps = 16/196 (8%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYAS--IGGGSPLRQITDAQGEALMEA 186 +DP +I +P AL Q L I R+ +S Y + GSPL + A + + A Sbjct: 30 SDPSVIEMPAAL--WQPLLRGIILPTRSWRSATFYQDSWLPQGSPLIVYSQAICQQVQAA 87 Query: 187 LCG-----------KDIPAKIKK---DGITKLVVLPLYPQFSISTSGSSLRLLESIFRED 324 L DI A +K DG K ++LPL+PQ++ ST G R +E+ Sbjct: 88 LPDWNVRLAMTYGQPDIGATLKAMVADGCEKPIILPLFPQYTQSTHGGIHRQVEA----- 142 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGD 504 + HT I S+Y + YI +AT K + + FS H +P A V GD Sbjct: 143 ---TGLPHTFIDSFYDQPTYIHLLAT---KVWQSYQAHHYDAVIFSYHSIPTAMVRH-GD 195 Query: 505 PYKAEMEECVDLIMEE 552 PY+ E E ++ E Sbjct: 196 PYQRECEATTKAVLAE 211
>HEMH_ERWCT (Q6D7Z4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 63.2 bits (152), Expect = 6e-10 Identities = 56/200 (28%), Positives = 96/200 (48%), Gaps = 19/200 (9%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALME 183 +D ++ PR L + PL + I + R+P+ + Y S+ GGSPL I+ Q +AL Sbjct: 33 SDRRVVDTPRLLWW---PLLRGIILPIRSPRVAKLYQSVWMEGGSPLLVISRRQHQALAA 89 Query: 184 ALCGKDIPA----------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIF 315 + D P K+ G+T+LVVLP+YPQ+S ST+ + L + Sbjct: 90 RM--PDTPVELGMSYGSPSLRSALDKLLAQGVTQLVVLPMYPQYSCSTTAAVWDGLAAQL 147 Query: 316 REDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 R++ L ++ I + + YI A+ +E+ + +P +++I S HG+P+ Y E Sbjct: 148 RDNRQLPAIR--FIRDYAEHPAYIAALKHRVEQSFAEHGEPDRLVI--SYHGIPVRYANE 203 Query: 496 AGDPYKAEMEECVDLIMEEL 555 GD Y + ++ L Sbjct: 204 -GDDYPQRCRATTEALIAAL 222
>HEMH_NITEU (Q82UK8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 364 Score = 63.2 bits (152), Expect = 6e-10 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 23/205 (11%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASI--GGGSPLRQITDAQGEALMEA 186 ++P I+ PR L + L I R KS + Y I GSPLR T A+ AL+ A Sbjct: 45 SEPRIVEFPRWLWWFI--LNGIILNVRPAKSAKKYEQIWTSEGSPLRVHT-ARQTALVAA 101 Query: 187 LCGKDIPAKI--------------------KKDGITKLVVLPLYPQFSISTSGSSLRLLE 306 L + + + K G +++VLPL+PQ++ S++G +L+ Sbjct: 102 LLEQQADSSLVVEYAMIIGNPSIAEKLQQMKVQGCDRILVLPLFPQYAASSTGC---VLD 158 Query: 307 SIFREDEYLVNMQH-TVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLA 483 +F E + N+ + ++ GYI A+A + K +P K++I F HGVP Sbjct: 159 GVFSELRKMRNIPDIRTVRHYHDDPGYIAALAQNVRDYWEKHGQPDKLIISF--HGVPRK 216 Query: 484 YVEEAGDPYKAEMEECVDLIMEELE 558 + E GDPY E ++ L+ E LE Sbjct: 217 TL-EMGDPYHCECQKTGRLLAEALE 240
>HEMH_YEREN (P43413) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 322 Score = 63.2 bits (152), Expect = 6e-10 Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 18/173 (10%) Frame = +1 Query: 91 RAPKSKEGYASI--GGGSPLRQITDAQGEALMEALCGKDIPA----------------KI 216 R+P+ + Y S+ GSPL + Q +AL E + +IP K+ Sbjct: 57 RSPRVAKLYQSVWMDEGSPLLVYSRRQQKALAERM--PEIPVELGMSYGSPNLPDAIDKL 114 Query: 217 KKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAM 396 G+TKLVVLPLYPQ+S STS + + I + L ++ + I + + YI A+ Sbjct: 115 LAQGVTKLVVLPLYPQYSCSTSAAVWDAVARILKGYRRLPSI--SFIRDYAEHPAYISAL 172 Query: 397 ATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 +E ++ KP ++++ F HG+P Y + GD Y E+ + E+ Sbjct: 173 KQSVENSFVQHGKPDRLVLSF--HGIPKRYA-QLGDDYPQRCEDTSRALRAEI 222
>HEMH_STAAR (Q6GFM4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 62.8 bits (151), Expect = 7e-10 Identities = 46/171 (26%), Positives = 79/171 (46%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 K+ Y IGG SPL TD Q +AL+ AL +D ++ KD Sbjct: 43 KDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHKD 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GIT+ + + L P +S + GS + + E+ +Q T + +Y++ +I+ Sbjct: 103 GITEAITVVLAPHYSSFSVGSYDKRAD----EEAAKYGIQLTHVKHYYEQPKFIEYWTNK 158 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 + + L + P+ + ++ SAH +P +E+ DPY E+E LI E+ Sbjct: 159 VNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQ 209
>HEMH_ACIAD (Q6F7N0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 340 Score = 62.8 bits (151), Expect = 7e-10 Identities = 53/202 (26%), Positives = 97/202 (48%), Gaps = 21/202 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGG-GSPLRQITDAQGEALMEAL 189 +D +I +P+ L + L F+ R + YAS+ G SP+R+I AQ +AL L Sbjct: 36 SDQRVIEIPKLLWKII--LYSFVLPFRPKRVAHAYASVWGQDSPMREILFAQTDALKRQL 93 Query: 190 CG-------KDIPAK---------IKKDGITK----LVVLPLYPQFSISTSGSSLRLLES 309 +PA I KD +++LPL+PQ+S +++ + Sbjct: 94 ISHYPQLDLNIVPAMTYGNPGVQHILKDLAASPQEHVILLPLFPQYSATSTAPLYDAFAN 153 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + +L + T+I +Y+ +I+A+ + +++ + KPQK+++ F HG+P Y Sbjct: 154 WIPKQRHLPGL--TIIKDYYRHPVFIQALVSSVQRFQQQHGKPQKLLMSF--HGIPQPYA 209 Query: 490 EEAGDPYKAEMEECVDLIMEEL 555 ++ GDPY E L+ ++L Sbjct: 210 DK-GDPYADRCRETARLVAKQL 230
>HEMH_HELPJ (Q9ZKD4) Probable ferrochelatase (EC 4.99.1.1) (Protoheme| ferro-lyase) (Heme synthetase) Length = 335 Score = 62.4 bits (150), Expect = 9e-10 Identities = 59/207 (28%), Positives = 96/207 (46%), Gaps = 18/207 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 N+F DP I+ + F++K + + I +R KSK+ Y +GG SPL IT A E L E Sbjct: 43 NMFDDPFILTIKN--NFMRKMVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNE 100 Query: 184 ------------------ALCGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 ++ +D+ K I LV +YPQ+S +T+ SS + Sbjct: 101 LDPSRFYTYAMRYTPPYASMVLQDLALK----EIESLVFFSMYPQYSSTTTLSSFNDAFN 156 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + E + VI +Y + + + I L K Q ++ FS HG+P + V Sbjct: 157 ALKSLE-TFRPKVRVIERFYADKKLNEIILNTI-LSALNNCKSQDFVLIFSVHGLPKSIV 214 Query: 490 EEAGDPYKAEMEECVDLIMEELEKRGM 570 +AGD Y+ E E V L+ E ++++ + Sbjct: 215 -DAGDTYQQECEHHVSLLKELMQQKNI 240
>HEMH_LACLA (Q9CFB4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 314 Score = 62.4 bits (150), Expect = 9e-10 Identities = 58/203 (28%), Positives = 97/203 (47%), Gaps = 17/203 (8%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISV-ARAPKSKEGYASI--GGGSPLRQITDAQGEALMEA 186 DP +I+ PR +L P+ I + R KS E Y I GSPL T AQ + L + Sbjct: 33 DPLVIQKPR---WLWLPILNGIILKVRPQKSAEMYKKIWTDEGSPLMIYTVAQAKQLQDM 89 Query: 187 LCGKDIP--------------AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRED 324 D+ A++K+ G+ ++ VLPLYPQ+S++T ++ ++ I +D Sbjct: 90 REDFDVRFAMTYGEPRIDKVIAEMKESGVEEITVLPLYPQYSLTTVEPVIQQVKKI--DD 147 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGD 504 + VI +++ E Y +A I + K+ + S HG+PL+YV + D Sbjct: 148 KI------KVIRDFHKVESYSDLLAESIRE---KWQANDYDKLVLSYHGIPLSYVTKKKD 198 Query: 505 PYKAEMEECVDLIMEELEKRGME 573 Y+ + +E L++ +L R E Sbjct: 199 AYEEQCKETTRLVVSKLGLREEE 221
>HEMH_OCEIH (Q8ERX9) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 312 Score = 62.4 bits (150), Expect = 9e-10 Identities = 49/173 (28%), Positives = 80/173 (46%), Gaps = 22/173 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 KE Y +IGG SPL +IT+ Q +AL + L +D ++ KD Sbjct: 44 KERYEAIGGISPLAKITEEQTKALEKKLNANQDQYEFKAYIGLKHIHPFIEDTVEEMAKD 103 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GI + + L L P +S S++ E +Q + WY G+IK A Sbjct: 104 GIKEAISLVLAPHYST----FSVKSYNKRANETAEKYGIQLDSVEDWYTEPGFIKFWADG 159 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEELE 558 I+ + + ++ ++ SAH +P +++ GDPYK ++EE LI+EE + Sbjct: 160 IKATYAEMTEEERNNSVLIVSAHSLPEKILKD-GDPYKHQLEETAKLIVEEAD 211
>HEMH_HELPY (P56107) Probable ferrochelatase (EC 4.99.1.1) (Protoheme| ferro-lyase) (Heme synthetase) Length = 334 Score = 62.0 bits (149), Expect = 1e-09 Identities = 57/205 (27%), Positives = 95/205 (46%), Gaps = 18/205 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALME 183 N+F DP I+ + F++K + + I +R KSK+ Y +GG SPL IT A E L + Sbjct: 43 NMFDDPFILTIKN--NFMRKMVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNK 100 Query: 184 ------------------ALCGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 ++ +D+ K + LV +YPQ+S +T+ SS + Sbjct: 101 LDPSRFYTYAMRYTPPYASMVLQDLALK----EVESLVFFSMYPQYSSTTTLSSFNDAFN 156 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + E + VI +Y + K + I L K Q ++ FS HG+P + + Sbjct: 157 ALKSLE-TFRPKVRVIERFYASKKLNKIILNTI-LNTLNNRKSQDFVLIFSVHGLPKSVI 214 Query: 490 EEAGDPYKAEMEECVDLIMEELEKR 564 +AGD Y+ E E V L+ E ++++ Sbjct: 215 -DAGDTYQQECEHHVSLLKELMQQK 238
>HEMH_DEIRA (Q9RV98) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 316 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/163 (26%), Positives = 77/163 (47%), Gaps = 20/163 (12%) Frame = +1 Query: 115 YASIGGGSPLRQITDAQGEALMEALCGKDIPAK------------------IKKDGITKL 240 Y IGG SPL + T AQ EA ME L P K + DGI + Sbjct: 51 YRLIGGKSPLPEFTRAQVEATMEQLASTGRPLKAYIGMRHWSPWIEDAVREMLDDGIEQA 110 Query: 241 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKEL 420 + + L PQ+S + + +++ + ++ + I +++ GYI A+A + + Sbjct: 111 IAIVLAPQYSSLSVAKYQKKIKAALEMNHGHIDFAY--IDNYHTEPGYITALADRVRIGI 168 Query: 421 LKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 +FP+ ++ V + SAH +P+ ++E GDPY ++ E L+ Sbjct: 169 QEFPEDERDDVHVILSAHSLPVRIIKE-GDPYADQLHETARLV 210
>HEMH_CHLCV (Q824K8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 318 Score = 61.2 bits (147), Expect = 2e-09 Identities = 53/186 (28%), Positives = 82/186 (44%), Gaps = 18/186 (9%) Frame = +1 Query: 52 FLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEALCGKDIP-------- 207 F+ K L FI+ RA K Y IGG SP+ Q T+ E L L I Sbjct: 40 FIHKRLFSFIAKKRALKVLPQYNCIGGFSPIYQDTELLAETLSSHLDAPVITFHRYLPDT 99 Query: 208 -----AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQ 372 ++K G +V +PL+P F+ + +GS +R + + L+N+ SW Sbjct: 100 HPHTIQQLKTLGDFPIVGVPLFPHFTYAVTGSIVRFIHNQLP----LLNI------SWVS 149 Query: 373 REGYIKAMATLIEKELLKFPKPQKV-----MIFFSAHGVPLAYVEEAGDPYKAEMEECVD 537 G + + +LKF + + + FSAHG+P+ +V + GDPY + E+ Sbjct: 150 HFGNHPEFISCMMDHILKFLQSHDISTHDCCLLFSAHGLPMRHVNK-GDPYNMQCEKSFR 208 Query: 538 LIMEEL 555 I E L Sbjct: 209 AISERL 214
>HEMH_STRPN (Q97R30) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 364 Score = 60.8 bits (146), Expect = 3e-09 Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 16/158 (10%) Frame = +1 Query: 130 GGSPLRQITDAQGEALMEALCGK----------------DIPAKIKKDGITKLVVLPLYP 261 GG+PL++IT Q AL+EA G D+ +++ DGI + + L L P Sbjct: 50 GGTPLQKIT-RQEVALVEARLGSEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEP 108 Query: 262 QFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQ 441 +S + + LES +Q VI WYQ E + A I K L + K Sbjct: 109 HYSFYSVMGYEKFLES--------KQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD 160 Query: 442 KVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + FSAH VP+ + + GDPY ++ E L+ E+L Sbjct: 161 SFKVIFSAHSVPI-FALDFGDPYIDQIFENSKLVAEKL 197
>HEMH_STAAW (P64126) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 K+ Y IGG SPL TD Q +AL+ AL +D ++ D Sbjct: 43 KDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GIT+ + + L P +S + GS + + E+ +Q T + +Y++ +I+ Sbjct: 103 GITEAITVVLAPHYSSFSVGSYDKRAD----EEAAKYGIQLTHVKHYYEQPKFIEYWTNK 158 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 + + L + P+ + ++ SAH +P +E+ DPY E+E LI E+ Sbjct: 159 VNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQ 209
>HEMH_STAAS (Q6G8A3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 K+ Y IGG SPL TD Q +AL+ AL +D ++ D Sbjct: 43 KDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GIT+ + + L P +S + GS + + E+ +Q T + +Y++ +I+ Sbjct: 103 GITEAITVVLAPHYSSFSVGSYDKRAD----EEAAKYGIQLTHVKHYYEQPKFIEYWTNK 158 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 + + L + P+ + ++ SAH +P +E+ DPY E+E LI E+ Sbjct: 159 VNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQ 209
>HEMH_STAAN (P64125) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 K+ Y IGG SPL TD Q +AL+ AL +D ++ D Sbjct: 43 KDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GIT+ + + L P +S + GS + + E+ +Q T + +Y++ +I+ Sbjct: 103 GITEAITVVLAPHYSSFSVGSYDKRAD----EEAAKYGIQLTHVKHYYEQPKFIEYWTNK 158 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 + + L + P+ + ++ SAH +P +E+ DPY E+E LI E+ Sbjct: 159 VNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQ 209
>HEMH_STAAM (P64124) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 K+ Y IGG SPL TD Q +AL+ AL +D ++ D Sbjct: 43 KDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GIT+ + + L P +S + GS + + E+ +Q T + +Y++ +I+ Sbjct: 103 GITEAITVVLAPHYSSFSVGSYDKRAD----EEAAKYGIQLTHVKHYYEQPKFIEYWTNK 158 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 + + L + P+ + ++ SAH +P +E+ DPY E+E LI E+ Sbjct: 159 VNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQ 209
>HEMH_STAAC (Q5HEU3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 307 Score = 60.8 bits (146), Expect = 3e-09 Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 22/171 (12%) Frame = +1 Query: 106 KEGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKD 225 K+ Y IGG SPL TD Q +AL+ AL +D ++ D Sbjct: 43 KDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHND 102 Query: 226 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 GIT+ + + L P +S + GS + + E+ +Q T + +Y++ +I+ Sbjct: 103 GITEAITVVLAPHYSSFSVGSYDKRAD----EEAAKYGIQLTHVKHYYEQPKFIEYWTNK 158 Query: 406 IEKELLKFPKPQK--VMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 + + L + P+ + ++ SAH +P +E+ DPY E+E LI E+ Sbjct: 159 VNETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQ 209
>HEMH_CHLTR (O84492) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 314 Score = 60.1 bits (144), Expect = 5e-09 Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 17/185 (9%) Frame = +1 Query: 55 LQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEALCGKDIP--------- 207 L +PL +I+ RAP YA +GGGSP+ Q T+ + L + L IP Sbjct: 40 LHRPLFSYIAKRRAPHVARQYAYLGGGSPIFQDTERLAQNLSQELQASVIPFHRYLPETH 99 Query: 208 ---AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQRE 378 + ++ +V +PL+P ++ + +GS +R +L ++ I SW + Sbjct: 100 RETLQALQESQGSIVGIPLFPHYTFAVTGSIIRF---------FLQHLPEKPI-SWITQF 149 Query: 379 GYIKAMATLIEKELLKFPKPQKVMI-----FFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 G + +++ + Q++ + FS HG+P ++ GDPY + + + + Sbjct: 150 GVHPEFVSCMQQHIRDCLAAQQIAVEDCYFLFSVHGLPQRHI-RLGDPYAQQCQASFEAL 208 Query: 544 MEELE 558 ELE Sbjct: 209 RGELE 213
>HEMH_BACHD (Q9KDK9) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 310 Score = 60.1 bits (144), Expect = 5e-09 Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 21/166 (12%) Frame = +1 Query: 109 EGYASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKDG 228 E Y +IGG SPL +ITD Q AL + L +D ++K+DG Sbjct: 45 ERYEAIGGVSPLAKITDDQAIALEQKLNELYDDIEFKSYLGLKHIDPFIEDAVEQMKEDG 104 Query: 229 ITKLVVLPLYPQFS-ISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 + + V + L P FS S + R E E + + + + SWY +I+ Sbjct: 105 VQEAVSIVLAPHFSTFSVKSYNGRAHE----ESKKIGGPRIQSVESWYDEPLFIQYWVDQ 160 Query: 406 IEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 + + K K + FSAH +P V + GDPY +++E DLI Sbjct: 161 VNDTMAKIEDKDKACVIFSAHSLPEKIV-DYGDPYPQQLKETADLI 205
>HEMH_STRR6 (Q8DQ04) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 364 Score = 59.3 bits (142), Expect = 8e-09 Identities = 48/158 (30%), Positives = 72/158 (45%), Gaps = 16/158 (10%) Frame = +1 Query: 130 GGSPLRQITDAQGEALMEALCGK----------------DIPAKIKKDGITKLVVLPLYP 261 GG+PL++IT Q L+EA G D+ +++ DGI + + L L P Sbjct: 50 GGTPLQKIT-RQEVTLVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEP 108 Query: 262 QFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQ 441 +S + + LES +Q VI WYQ E + A I K L + K Sbjct: 109 HYSFYSVMGYEKFLES--------KQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD 160 Query: 442 KVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + FSAH VP+ + + GDPY ++ E L+ E+L Sbjct: 161 SFKVIFSAHSVPI-FALDFGDPYIDQIFENSKLVAEKL 197
>HEMH2_BACCZ (Q63EK7) Ferrochelatase 2 (EC 4.99.1.1) (Protoheme ferro-lyase 2)| (Heme synthetase 2) Length = 319 Score = 58.9 bits (141), Expect = 1e-08 Identities = 46/166 (27%), Positives = 70/166 (42%), Gaps = 23/166 (13%) Frame = +1 Query: 115 YASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKDGIT 234 Y +IGG SPL +IT Q L +++ +D ++K+DGI Sbjct: 47 YKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIE 106 Query: 235 K---LVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 + +V+ P Y FSI E R E + I WY +I A Sbjct: 107 QAISIVLAPHYSTFSIKAYN------ERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ 160 Query: 406 IEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 I++ K +K ++ FSAH +P + AGDPY +++ DLI Sbjct: 161 IKETFTKIEDKEKAVVIFSAHSLPEKII-AAGDPYVEQLQHTADLI 205
>HEMH2_BACAN (Q81TU9) Ferrochelatase 2 (EC 4.99.1.1) (Protoheme ferro-lyase 2)| (Heme synthetase 2) Length = 319 Score = 58.9 bits (141), Expect = 1e-08 Identities = 46/166 (27%), Positives = 70/166 (42%), Gaps = 23/166 (13%) Frame = +1 Query: 115 YASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKDGIT 234 Y +IGG SPL +IT Q L +++ +D ++K+DGI Sbjct: 47 YKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIE 106 Query: 235 K---LVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 + +V+ P Y FSI E R E + I WY +I A Sbjct: 107 QAISIVLAPHYSTFSIKAYN------ERAIRLSEEIGGPVIKPIDQWYDEPKFISYWADQ 160 Query: 406 IEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 I++ K +K ++ FSAH +P + AGDPY +++ DLI Sbjct: 161 IKETFTKIEDKEKAVVIFSAHSLPEKII-AAGDPYVEQLQHTADLI 205
>HEMH_XANCP (Q8P3H6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 318 Score = 58.5 bits (140), Expect = 1e-08 Identities = 52/171 (30%), Positives = 82/171 (47%), Gaps = 16/171 (9%) Frame = +1 Query: 91 RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDI--------PAK------IKK 222 R PKS E YA + GSPL T E L + + + PA ++ Sbjct: 58 RGPKSAEKYAKVWLPDGSPLAVYTRRLTEGLQQVMPDWHVTWAMRYGAPALRKALDGLRA 117 Query: 223 DGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMAT 402 GI ++VVLPLYPQ+S +T+ S ++++ +R + ++ VI + + G++ A+A Sbjct: 118 RGIKRIVVLPLYPQYSTTTTASIQDVVDA-WRPSAPEIAVE--VIQDYCEDAGWVAAIAD 174 Query: 403 LIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 I + +K+M FS HG+P V AGDPY + E I+ L Sbjct: 175 SIRTHWQVHGRSEKLM--FSFHGLP-QRVANAGDPYPQQCERSAQAIVTAL 222
>HEMH_LISIN (Q929G2) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 309 Score = 57.8 bits (138), Expect = 2e-08 Identities = 52/205 (25%), Positives = 91/205 (44%), Gaps = 23/205 (11%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + D DI R +R KP + I+ R Y +IGG SPL +IT+AQ L +AL Sbjct: 16 YKDEDIERYYTDIRHGHKPSEEMIADLRGR-----YHAIGGLSPLAKITEAQAYGLEKAL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQF-SISTSGSSLRLLE 306 +D + KDGI + + + L P + S S + R + Sbjct: 71 NDAQDEVEFKAYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFSVEAYNKRAKD 130 Query: 307 SIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKV--MIFFSAHGVPL 480 + + L + I WY++ +I+ A I + + P + + ++ SAH +P Sbjct: 131 AA----DKLGGIHIQAINDWYKQPKFIQMWADRINETAKQIPAEELIDTVLIVSAHSLP- 185 Query: 481 AYVEEAGDPYKAEMEECVDLIMEEL 555 +++ DPY +++E DLI +++ Sbjct: 186 EKIKQHNDPYPDQLQETADLIFDKV 210
>HEMH_METCA (Q607T4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 325 Score = 57.8 bits (138), Expect = 2e-08 Identities = 50/198 (25%), Positives = 98/198 (49%), Gaps = 16/198 (8%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISV-ARAPKSKEGYASIGG--GSPL---------RQIT 156 +DP ++ +PR L + P+ + + R+ KS Y +I GSPL R Sbjct: 35 SDPRVVEIPRVLWW---PILNLVVLRTRSRKSAHAYRTIWTERGSPLLAYTQDLRDRLAA 91 Query: 157 DAQGEALMEALCGKDIPAKIK----KDGITKLVVLPLYPQFSISTSGSSLRLLESIFRED 324 D + A+ A+ + ++K ++ + +VVLPLYPQ+S +T+GS+ + + Sbjct: 92 DGRFAAVEIAMRYGNPSVRLKLEELRNRVETIVVLPLYPQYSAATTGSAFDAVCDTLKTW 151 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGD 504 ++ ++ I +++ Y++A+A I + +P++++ FS HG+P ++ GD Sbjct: 152 RHIPSLH--FIGDYHRSPKYLEAVAASIRSFWQEHGRPERLV--FSFHGLPKCCIDR-GD 206 Query: 505 PYKAEMEECVDLIMEELE 558 PY ++ + I LE Sbjct: 207 PYASQCQATAQGIARLLE 224
>HEMH2_BACHK (Q6HM28) Ferrochelatase 2 (EC 4.99.1.1) (Protoheme ferro-lyase 2)| (Heme synthetase 2) Length = 319 Score = 57.8 bits (138), Expect = 2e-08 Identities = 46/166 (27%), Positives = 70/166 (42%), Gaps = 23/166 (13%) Frame = +1 Query: 115 YASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKDGIT 234 Y +IGG SPL +IT Q L +++ +D ++K+DGI Sbjct: 47 YKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIE 106 Query: 235 K---LVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 + +V+ P Y FSI E R E + I WY +I A Sbjct: 107 QAISIVLAPHYSTFSIKAYN------ERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ 160 Query: 406 IEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 I++ K +K ++ FSAH +P + AGDPY +++ DLI Sbjct: 161 IKETFTKIEDNEKAVVIFSAHSLPEKII-AAGDPYVEQLQYTADLI 205
>HEMH2_BACC1 (Q73C08) Ferrochelatase 2 (EC 4.99.1.1) (Protoheme ferro-lyase 2)| (Heme synthetase 2) Length = 319 Score = 57.8 bits (138), Expect = 2e-08 Identities = 45/166 (27%), Positives = 70/166 (42%), Gaps = 23/166 (13%) Frame = +1 Query: 115 YASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKDGIT 234 Y +IGG SPL +IT Q L +++ +D ++K+DGI Sbjct: 47 YKAIGGISPLAKITKEQAHKLTDSMNNIFTEYEFNCYLGLKHIAPFIEDAVEEMKRDGIE 106 Query: 235 K---LVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 + +V+ P Y FSI + R E + I WY +I A Sbjct: 107 QAISIVLAPHYSTFSIKAYN------DRAIRLSEEIGGPVIEPIEQWYDEPKFISYWADQ 160 Query: 406 IEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLI 543 I++ K +K ++ FSAH +P + AGDPY +++ DLI Sbjct: 161 IKETFTKIEDKEKAVVIFSAHSLPEKII-AAGDPYVKQLQHTADLI 205
>HEMH_XANAC (Q8PEX0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 318 Score = 57.4 bits (137), Expect = 3e-08 Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 16/171 (9%) Frame = +1 Query: 91 RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDI--------PA------KIKK 222 R PKS E YA + GSPL T L + + PA +++ Sbjct: 58 RGPKSAEKYAKVWLPEGSPLAVYTRRLAGGLQAVMPDWHVEWAMRYGEPALRKTLDRLRA 117 Query: 223 DGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMAT 402 GI ++VVLPLYPQ+S +T+ S ++++ +R + ++ VI + + G++ A+A Sbjct: 118 RGIKRIVVLPLYPQYSTTTTASIQDVVDA-WRTSAPEIAVE--VIQDYCEDTGWVAAIAE 174 Query: 403 LIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 I + +K+M FS HG+P V +AGDPY + E I+ L Sbjct: 175 SIRAHWQVHGRSEKLM--FSFHGLP-QRVADAGDPYPQQCERSAQAIVAAL 222
>HEMH_LISMO (Q8Y565) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 309 Score = 57.4 bits (137), Expect = 3e-08 Identities = 53/205 (25%), Positives = 89/205 (43%), Gaps = 23/205 (11%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + D DI R +R KP + I+ R Y +IGG SPL +IT+AQ L +AL Sbjct: 16 YKDEDIERYYTDIRHGHKPSEEMIADLRGR-----YHAIGGLSPLAKITEAQAYGLEKAL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQF-SISTSGSSLRLLE 306 +D + KDGI + + + L P + S S + R E Sbjct: 71 NDSQDEVEFKAYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFSVEAYNKRAKE 130 Query: 307 SIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQ--KVMIFFSAHGVPL 480 + + L + I WY++ +I+ A I + + P + ++ SAH +P Sbjct: 131 AA----DKLGGPRINAINDWYKQPKFIQMWADRINETAKQIPADELLDTVLIVSAHSLP- 185 Query: 481 AYVEEAGDPYKAEMEECVDLIMEEL 555 +++ DPY +++E D I E++ Sbjct: 186 EKIKQHNDPYPNQLQETADFIFEKV 210
>HEMH_YERPS (Q05338) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 57.0 bits (136), Expect = 4e-08 Identities = 45/164 (27%), Positives = 77/164 (46%), Gaps = 18/164 (10%) Frame = +1 Query: 91 RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPA----------------KI 216 R+P+ + Y S+ GSPL + Q +AL + DIP K+ Sbjct: 57 RSPRVAKLYQSVWMEEGSPLLVYSRRQQKALAARM--PDIPVELGMSYGSPNLPEAIEKL 114 Query: 217 KKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAM 396 G+T LV+LPLYPQ+S STS + + + + L ++ + I + + YI A+ Sbjct: 115 LAQGVTNLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSI--SFIRDYAEHPAYISAL 172 Query: 397 ATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEE 528 +E+ + +P ++++ F HG+P Y + GD Y E+ Sbjct: 173 KQSVERSFAEHGQPDRLVMSF--HGIPKRYA-QLGDDYPIRCED 213
>HEMH_YERPE (Q8ZC98) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 57.0 bits (136), Expect = 4e-08 Identities = 45/164 (27%), Positives = 77/164 (46%), Gaps = 18/164 (10%) Frame = +1 Query: 91 RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPA----------------KI 216 R+P+ + Y S+ GSPL + Q +AL + DIP K+ Sbjct: 57 RSPRVAKLYQSVWMEEGSPLLVYSRRQQKALAARM--PDIPVELGMSYGSPNLPEAIEKL 114 Query: 217 KKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAM 396 G+T LV+LPLYPQ+S STS + + + + L ++ + I + + YI A+ Sbjct: 115 LAQGVTNLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSI--SFIRDYAEHPAYISAL 172 Query: 397 ATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEE 528 +E+ + +P ++++ F HG+P Y + GD Y E+ Sbjct: 173 KQSVERSFAEHGQPDRLVMSF--HGIPKRYA-QLGDDYPIRCED 213
>HEMH_LISMF (Q71XF4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 309 Score = 57.0 bits (136), Expect = 4e-08 Identities = 52/205 (25%), Positives = 90/205 (43%), Gaps = 23/205 (11%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + D DI R +R KP + I+ R Y +IGG SPL +IT+AQ L +AL Sbjct: 16 YKDEDIERYYTDIRHGHKPSEEMIADLRGR-----YHAIGGLSPLAKITEAQAYGLEKAL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQF-SISTSGSSLRLLE 306 +D + KDGI + + + L P + S S + R + Sbjct: 71 NESQDEVEFKAYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFSVEAYNKRAKD 130 Query: 307 SIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQ--KVMIFFSAHGVPL 480 + + L ++ I WY++ +I+ A I + + P + ++ SAH +P Sbjct: 131 AA----DKLGGLRIKAINDWYKQPKFIQMWADRINETAKQIPADELLDTVLIVSAHSLP- 185 Query: 481 AYVEEAGDPYKAEMEECVDLIMEEL 555 +++ DPY +++E D I E++ Sbjct: 186 EKIKQHNDPYPDQLQETADFIFEKV 210
>HEMH_COXBU (Q83FA4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 343 Score = 56.6 bits (135), Expect = 5e-08 Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPL----RQITDAQGEA 174 +DP +I +P +R++ L I R +S + Y I GSPL + + GE Sbjct: 36 SDPKVIDVPSLVRWIIVHLC--ILPFRPKRSAKLYQKIWMPEGSPLLVYSEMLRERVGET 93 Query: 175 LMEALC-------GKD----IPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 L + C GK K+++ +L+VLPL+PQ+S ST+ S+ LE + + Sbjct: 94 LGDDFCVALGMRYGKPSIETALKKLQEAQCRQLIVLPLFPQYSTSTTASA---LEEVRAK 150 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAG 501 + + + TVI +++ YI +M TLI + L +F Q FS HG+P ++ ++G Sbjct: 151 NSF---KEMTVIDRFFEEPHYIDSMTTLIHENLNEF---QPDYFLFSYHGLPERHLVKSG 204
>HEMH_ENTFA (Q833G5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 313 Score = 56.2 bits (134), Expect = 7e-08 Identities = 37/109 (33%), Positives = 62/109 (56%) Frame = +1 Query: 229 ITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLI 408 I +L V+P+YPQ+S +T GS + + F + + +V+++ I S+Y YI + I Sbjct: 117 IEELNVIPMYPQYSGTTVGSVFDSVMNYFIKSDRIVDIK--FIRSFYNNPQYIDYFSKKI 174 Query: 409 EKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 + L + P I FS HG+P++YV++ GD Y E + LIM++L Sbjct: 175 NEALNESPID---AIVFSYHGIPMSYVKD-GDNYPKECTKTTKLIMDKL 219
>HEMH_ECOLI (P23871) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 56.2 bits (134), Expect = 7e-08 Identities = 49/171 (28%), Positives = 77/171 (45%), Gaps = 17/171 (9%) Frame = +1 Query: 49 RFLQKPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPA--- 210 R L PL + + + R+P+ + YAS+ GGSPL + Q +AL + L + Sbjct: 42 RLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPEMPVALGMS 101 Query: 211 -----------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVI 357 ++ + + +VVLPLYPQFS ST G+ L I + + + I Sbjct: 102 YGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGI--SFI 159 Query: 358 PSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPY 510 + YI A+A + K +P ++ S HG+P Y +E GD Y Sbjct: 160 RDYADNHDYINALANSVRASFAKHGEPD--LLLLSYHGIPQRYADE-GDDY 207
>HEMH_ECO57 (Q8XD39) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 56.2 bits (134), Expect = 7e-08 Identities = 49/171 (28%), Positives = 77/171 (45%), Gaps = 17/171 (9%) Frame = +1 Query: 49 RFLQKPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPA--- 210 R L PL + + + R+P+ + YAS+ GGSPL + Q +AL + L + Sbjct: 42 RLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMS 101 Query: 211 -----------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVI 357 ++ + + +VVLPLYPQFS ST G+ L I + + + I Sbjct: 102 YGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGI--SFI 159 Query: 358 PSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPY 510 + YI A+A + K +P ++ S HG+P Y +E GD Y Sbjct: 160 RDYADNHDYINALANSVRASFAKHGEPD--LLLLSYHGIPQRYADE-GDDY 207
>HEMH_MANSM (Q65SV7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 323 Score = 56.2 bits (134), Expect = 7e-08 Identities = 52/202 (25%), Positives = 90/202 (44%), Gaps = 21/202 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVA-RAPKSKEGYASIGG--GSPLRQITDAQGEALME 183 +DP ++ LPR + PL I + R+ + + Y +I GSPL IT Q L E Sbjct: 33 SDPRVVDLPR---WKWLPLLNGIILPIRSRRIAKNYGAIWTEQGSPLFAITQKQKALLTE 89 Query: 184 ALCGKDIPAKIK------------------KDGITKLVVLPLYPQFSISTSGSSLRLLES 309 + I+ + + K++VLPLYPQ+S +T+ + Sbjct: 90 FFQQRQQNVIIEIGMTYGNPSMQYAIDNLIEQKVDKIIVLPLYPQYSSTTTAPVFDVFAQ 149 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 + ++V + I S++ E YI+A+ I+ L + FS HG+P Y Sbjct: 150 ALKRHRHIVPFE--FIHSYHLDENYIEALVKSIKVRL-----KNDEFLLFSFHGIPKRY- 201 Query: 490 EEAGDPYKAEMEECVDLIMEEL 555 E+ GD Y+ + E+ ++++L Sbjct: 202 EQEGDFYRPQCEQTAQAVVQKL 223
>HEMH_BORPA (Q7W515) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 362 Score = 55.5 bits (132), Expect = 1e-07 Identities = 51/206 (24%), Positives = 94/206 (45%), Gaps = 22/206 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKS-KEGYASIG--GGSPLRQITDAQGEALME 183 +DP +I +PR +L P+ + +A PK YA I GSPL + Q + + Sbjct: 63 SDPRVIEIPR---YLWMPILHGLVLAMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQ 119 Query: 184 ALCGKDIPAKI------------------KKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L + + A++ ++ G ++ +PLYPQ++ ST+ + ++++ Sbjct: 120 GLAARGVHAEVELAMRYGKPSIPAAITALRERGCDHILAVPLYPQYAASTTAT---VVDA 176 Query: 310 IFREDEYLVNMQH-TVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAY 486 + R L + + ++ Y++A A I + +PQK+++ F HG+P Y Sbjct: 177 VTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSF--HGLP-RY 233 Query: 487 VEEAGDPYKAEMEECVDLIMEELEKR 564 E GDPY + + L+ E L R Sbjct: 234 SIELGDPYYRDCLDTARLLRERLGLR 259
>HEMH_BORBR (Q7WGI0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 362 Score = 55.5 bits (132), Expect = 1e-07 Identities = 51/206 (24%), Positives = 94/206 (45%), Gaps = 22/206 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKS-KEGYASIG--GGSPLRQITDAQGEALME 183 +DP +I +PR +L P+ + +A PK YA I GSPL + Q + + Sbjct: 63 SDPRVIEIPR---YLWMPILHGLVLAMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQ 119 Query: 184 ALCGKDIPAKI------------------KKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L + + A++ ++ G ++ +PLYPQ++ ST+ + ++++ Sbjct: 120 GLAARGVHAEVELAMRYGKPSIPAAITALRERGCDHILAVPLYPQYAASTTAT---VVDA 176 Query: 310 IFREDEYLVNMQH-TVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAY 486 + R L + + ++ Y++A A I + +PQK+++ F HG+P Y Sbjct: 177 VTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSF--HGLP-RY 233 Query: 487 VEEAGDPYKAEMEECVDLIMEELEKR 564 E GDPY + + L+ E L R Sbjct: 234 SIELGDPYYRDCLDTARLLRERLGLR 259
>HEMH_ECOL6 (Q8FK83) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 55.1 bits (131), Expect = 1e-07 Identities = 48/171 (28%), Positives = 77/171 (45%), Gaps = 17/171 (9%) Frame = +1 Query: 49 RFLQKPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPA--- 210 R L PL + + + R+P+ + YAS+ GGSPL + Q +AL + L + Sbjct: 42 RLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMS 101 Query: 211 -----------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVI 357 ++ + + +VVLPLYPQ+S ST G+ L I + + + I Sbjct: 102 YGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGI--SFI 159 Query: 358 PSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPY 510 + YI A+A + K +P ++ S HG+P Y +E GD Y Sbjct: 160 RDYADNHDYINALANSVRASFAKHGEPD--LLLLSYHGIPQRYADE-GDDY 207
>HEMH_PHOPR (Q6LTE0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 322 Score = 54.3 bits (129), Expect = 3e-07 Identities = 44/173 (25%), Positives = 80/173 (46%), Gaps = 18/173 (10%) Frame = +1 Query: 91 RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIP----------------AKI 216 R+PK + Y S+ GSPL + Q +AL + L ++P A++ Sbjct: 57 RSPKVAKLYQSVWMEDGSPLMVYSQRQRQALEKQL---NVPVALGMTYGTPSIATGLAEL 113 Query: 217 KKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAM 396 K+ G K++VLPLYPQ+S +T+ + + ++ ++ ++ I ++ YI A+ Sbjct: 114 KQQGCNKVLVLPLYPQYSGTTTAAVFDRIAKELKQQPHIPELR--FINHYFDHPDYIDAL 171 Query: 397 ATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 A + + +P ++ S HG+P Y + GDPY + + E L Sbjct: 172 ALSVTDFWAENGEPDYLLC--SYHGIPKRYADN-GDPYPQHCHATTEKLAERL 221
>HEMH_SHIFL (Q83SE5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 54.3 bits (129), Expect = 3e-07 Identities = 50/173 (28%), Positives = 77/173 (44%), Gaps = 19/173 (10%) Frame = +1 Query: 49 RFLQKPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPA--- 210 R L PL + + + R+P+ + YAS+ GSPL + Q +AL + L D P Sbjct: 42 RLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYSRQQQQALAQRL--PDTPVALG 99 Query: 211 -------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHT 351 ++ + + +VVLPLYPQFS ST G+ L I + + + Sbjct: 100 MSYGSPSLESSVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGI--S 157 Query: 352 VIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPY 510 I + YI A+A + K +P ++ S HG+P Y +E GD Y Sbjct: 158 FIRDYADNHDYINALANSVRASFAKHGEPD--LLLLSYHGIPQRYADE-GDDY 207
>HEMH_RHIME (Q92M52) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 339 Score = 53.9 bits (128), Expect = 3e-07 Identities = 37/119 (31%), Positives = 66/119 (55%), Gaps = 5/119 (4%) Frame = +1 Query: 214 IKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQH----TVIPSWYQREG 381 ++K G +++V PLYPQ++ +T+ + + + F E L+ M+ +P ++ Sbjct: 128 LQKAGCERILVFPLYPQYAAATTAT---VNDKAF---EALLKMRWQPALRTVPPYHDDPV 181 Query: 382 YIKAMATLIEKELLKFP-KPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 YI A+AT I K L +P+ V+ F HG+P +Y E+ GDPY + ++ L+ E+L Sbjct: 182 YIDALATSINKHLATLDWEPELVLASF--HGIPKSYFEK-GDPYYCQCQKTARLLREKL 237
>HEMH_BORPE (Q7VVX8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 362 Score = 53.9 bits (128), Expect = 3e-07 Identities = 50/206 (24%), Positives = 93/206 (45%), Gaps = 22/206 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKS-KEGYASIG--GGSPLRQITDAQGEALME 183 +DP +I +PR +L P+ + + PK YA I GSPL + Q + + Sbjct: 63 SDPRVIEIPR---YLWMPILHGLVLTMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQ 119 Query: 184 ALCGKDIPAKI------------------KKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 L + + A++ ++ G ++ +PLYPQ++ ST+ + ++++ Sbjct: 120 GLAARGVHAEVELAMRYGKPSIPAAITALRERGCDHILAVPLYPQYAASTTAT---VVDA 176 Query: 310 IFREDEYLVNMQH-TVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAY 486 + R L + + ++ Y++A A I + +PQK+++ F HG+P Y Sbjct: 177 VTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSF--HGLP-RY 233 Query: 487 VEEAGDPYKAEMEECVDLIMEELEKR 564 E GDPY + + L+ E L R Sbjct: 234 SIELGDPYYRDCLDTARLLRERLGLR 259
>HEMH_BURMA (Q62HD1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 367 Score = 53.9 bits (128), Expect = 3e-07 Identities = 50/207 (24%), Positives = 93/207 (44%), Gaps = 26/207 (12%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPLRQITDAQGEALMEA 186 +DP ++ +P+ + Q L I R S + YA++ GSPLR T+ Q E++ Sbjct: 56 SDPRVVEIPQLV--WQVILCTLILPLRGRASAKKYAAVWLPEGSPLRVYTERQVESVKPL 113 Query: 187 LCGK------------------DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESI 312 D+ A++K+ G ++++LP+YPQ+S ST+ ++ ++ Sbjct: 114 FAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSSSTTATA---FDAA 170 Query: 313 FREDEYLVNMQHT-VIPSWYQREGYIKAMATLIEKELLKFPKP-----QKVMIFFSAHGV 474 F + N + + YI A+A + + +P K+++ F HGV Sbjct: 171 FAALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSF--HGV 228 Query: 475 PLAYVEEAGDPYKAEMEECVDLIMEEL 555 P + + GDPY + ++ L+M L Sbjct: 229 PKRTL-DLGDPYHDQCQQTAALLMSAL 254
>HEMH2_BACCR (Q81GN7) Ferrochelatase 2 (EC 4.99.1.1) (Protoheme ferro-lyase 2)| (Heme synthetase 2) Length = 319 Score = 53.9 bits (128), Expect = 3e-07 Identities = 43/168 (25%), Positives = 71/168 (42%), Gaps = 23/168 (13%) Frame = +1 Query: 115 YASIGGGSPLRQITDAQGEALMEALCG--------------------KDIPAKIKKDGIT 234 Y +IGG SPL +IT Q L +++ +D ++K++GI Sbjct: 47 YKAIGGISPLAKITKEQAHKLTDSMNNIFTEYEFTCYLGLKHTAPFIEDAVEEMKRNGIE 106 Query: 235 K---LVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATL 405 + +V+ P Y FSI + R + + I WY +I A Sbjct: 107 QTISIVLAPHYSTFSIKAYN------DRAIRLSKEIGGPVIESIEQWYDEPKFISYWADQ 160 Query: 406 IEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIME 549 I++ + +K ++ FSAH +P + AGDPY +++ DLI E Sbjct: 161 IKETFTEIDDKEKAVVIFSAHSLPEKII-AAGDPYVEQLKHTADLIAE 207
>HEMH_PHOLL (Q7N0P6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 325 Score = 53.5 bits (127), Expect = 4e-07 Identities = 48/186 (25%), Positives = 84/186 (45%), Gaps = 17/186 (9%) Frame = +1 Query: 49 RFLQKPLAQ-FISVARAPKSKEGYASI--GGGSPLRQITDAQGEALMEALCGKDIPA--- 210 RF+ KP+ F+ R+ + + Y I GSPL Q + L E L G + Sbjct: 42 RFIWKPILYGFVLPFRSSRVAKLYQKIWTDEGSPLLVYGRRQQKLLAERLAGIPVELGMN 101 Query: 211 -----------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVI 357 + K + +L+VLPLYPQ+S S+S + + + ++ + M I Sbjct: 102 YGSPSLEQAIDNLLKQNVEQLIVLPLYPQYSGSSSAAVFDGVSLVLQKYRTIPGMH--FI 159 Query: 358 PSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVD 537 S+ YI A+ IE+ K +P ++++ S HG+P +V + GD Y + + Sbjct: 160 RSYADHPAYISALKETIEQSFDKHGQPDRLLL--SYHGIPQRFV-DTGDIYAEQCKLTTR 216 Query: 538 LIMEEL 555 L+ + + Sbjct: 217 LLKQAI 222
>HEMH_BURPS (Q63R43) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 367 Score = 53.5 bits (127), Expect = 4e-07 Identities = 50/207 (24%), Positives = 93/207 (44%), Gaps = 26/207 (12%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG--GGSPLRQITDAQGEALMEA 186 +DP ++ +P+ + Q L I R S + YA++ GSPLR T+ Q E++ Sbjct: 56 SDPRVVEIPQLV--WQVILRTLILPLRGRASAKKYAAVWLPEGSPLRVYTERQVESVKPL 113 Query: 187 LCGK------------------DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESI 312 D+ A++K+ G ++++LP+YPQ+S ST+ ++ ++ Sbjct: 114 FAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSSSTTATA---FDAA 170 Query: 313 FREDEYLVNMQHT-VIPSWYQREGYIKAMATLIEKELLKFPKP-----QKVMIFFSAHGV 474 F + N + + YI A+A + + +P K+++ F HGV Sbjct: 171 FAALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSF--HGV 228 Query: 475 PLAYVEEAGDPYKAEMEECVDLIMEEL 555 P + + GDPY + ++ L+M L Sbjct: 229 PKRTL-DLGDPYHDQCQQTAALLMSAL 254
>HEMH_RHOCA (Q59735) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 351 Score = 53.1 bits (126), Expect = 6e-07 Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 29/194 (14%) Frame = +1 Query: 61 KPLAQFISVARAP-KSKEGYASIGGG----SPLRQITDAQGEALMEAL------------ 189 +PL Q I +++ P S Y SI SPL IT Q L A+ Sbjct: 63 QPLLQLIILSKRPFTSGNNYRSIWNEERDESPLMTITRDQVRKLRAAVETRYGAGNVVVD 122 Query: 190 --------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSS----LRLLESIFREDEYL 333 +D+ + G +++ LPLYPQ++ +TS ++ R L + R+ Sbjct: 123 FCMRYGNPSTRDVLDDMLAQGCERILFLPLYPQYAGATSATANDQFFRALMQVKRQP--- 179 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYK 513 +P ++ R YI+A+A+ +E+ V++ S HG+P Y E GDPY Sbjct: 180 ---AARTVPEYFARPSYIEALASSVERVYATLDTRPDVLV-ASYHGMPKRYHRE-GDPYH 234 Query: 514 AEMEECVDLIMEEL 555 + ++ L+ E L Sbjct: 235 CQCQKTSRLLRERL 248
>HEMH_STRMU (Q8CWW4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 319 Score = 53.1 bits (126), Expect = 6e-07 Identities = 54/198 (27%), Positives = 83/198 (41%), Gaps = 21/198 (10%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKP-LAQFISVARAPKSKEGYASI--GGGSPLRQITDAQGEALME 183 AD +I P+ FL KP L FI R K K Y + GSPL Q +AL Sbjct: 33 ADSRVIDYPK---FLWKPILYSFILPFRPRKVKPLYQHVWTNEGSPLYANAIGQEKALQA 89 Query: 184 ALCGK------------------DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 D+ + K+ + K++VLPL+PQ+S +T+ + Sbjct: 90 HFDQSEHGVLVRATMAYSKPSISDVVDEFLKEKVAKMIVLPLFPQYSSTTTAAIFDAFAQ 149 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYV 489 ++ + + I +Y+R YI+A+A I + + + FS HG+P YV Sbjct: 150 SLKKKKDIPPFD--FIHHYYERPSYIQALAQTIHLQ-------ENEHLLFSFHGIPQRYV 200 Query: 490 EEAGDPYKAEMEECVDLI 543 E GD Y ++ LI Sbjct: 201 IE-GDYYTEHCQQTAQLI 217
>HEMH_FRATT (Q5NFT3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 333 Score = 52.8 bits (125), Expect = 7e-07 Identities = 37/124 (29%), Positives = 66/124 (53%), Gaps = 5/124 (4%) Frame = +1 Query: 202 IPAKIKK---DGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTV--IPSW 366 I +KIK G T++++ PLYPQ+S +T+ + + + ++R L Q T+ I + Sbjct: 114 IESKIKSLQDQGATEIIIFPLYPQYSATTTAT---VYDEVYRVLSKL-RWQPTIKGINPY 169 Query: 367 YQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIM 546 Y + +I+ ++ I++ L K + FS HG+P Y ++ GDPY + L+ Sbjct: 170 YDNKFHIQTISQQIKEHLKKLDSTPDT-VLFSFHGLPKEYFDK-GDPYYCHCYKTYRLVK 227 Query: 547 EELE 558 EEL+ Sbjct: 228 EELQ 231
>HEMH_BDEBA (Q6MHT3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 335 Score = 52.8 bits (125), Expect = 7e-07 Identities = 44/178 (24%), Positives = 83/178 (46%), Gaps = 18/178 (10%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVAR-APKSKEGYASIG--GGSPLRQITDAQGEALMEA 186 D D+I LP LR+ PL + V R AP S E Y + GSP+ T L E Sbjct: 32 DEDVITLPYVLRW---PLVNLLIVPRRAPFSAENYKKVWMKEGSPIAVYTRRFAALLQEE 88 Query: 187 LCGKDIPA---------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 L + + +++ G+ +++V P++PQ++ +T+GSS +L E + ++ Sbjct: 89 LKDQFVVKVGLQYSEPSVESALKDLQQAGVDEILVAPMFPQYAEATNGSSFKLAERMAKK 148 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 ++ +P+++ ++ L+E+ L + FS HG+P ++V + Sbjct: 149 LHLTAPLRR--LPAFFDDASFVGTSVKLVEETL---QDKEVDHYLFSFHGLPESHVRK 201
>HEMH_AGRT5 (Q8U9F7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 344 Score = 52.4 bits (124), Expect = 1e-06 Identities = 44/164 (26%), Positives = 78/164 (47%), Gaps = 24/164 (14%) Frame = +1 Query: 136 SPLRQITDAQGEALMEALCGKDIPAKI-------------------KKDGITKLVVLPLY 258 S LR T +QGE + AL KD P + K+ G K+++ PLY Sbjct: 90 SYLRTYTRSQGELMAAAL--KDFPNVVVDWAMRYGQPSIASRIDALKEQGCEKILLFPLY 147 Query: 259 PQFSISTSGSSLRLLESIFREDEYLVNMQH----TVIPSWYQREGYIKAMATLIEKELLK 426 PQ++ ST+ + + + F E+L+ ++ +P ++ YI+ +A ++ L Sbjct: 148 PQYAASTTAT---VNDKAF---EHLMKLRWQPAIRTVPPYHDDPAYIEGLAASVKNHLAT 201 Query: 427 FP-KPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 +P+ M+ S HG+P +Y ++ GDPY ++ L+ E L Sbjct: 202 LDWEPE--MLITSFHGIPQSYFKK-GDPYYCHCQKTARLLREAL 242
>HEMH_CHLPN (Q9Z7V1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 327 Score = 52.4 bits (124), Expect = 1e-06 Identities = 50/197 (25%), Positives = 83/197 (42%), Gaps = 16/197 (8%) Frame = +1 Query: 1 VNLFADPDIIR--LPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEA 174 ++L D D+ LPR L + L FI+ R PK Y S+ SP+ T+ + Sbjct: 25 ISLLTDRDVTGTFLPRVLH---RHLFTFIAKKRVPKVLPQYQSLQNWSPIYFDTETLAKT 81 Query: 175 LMEALCGKDIP-------------AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIF 315 L E L IP ++ ++ +PL+P F+ S +GS +R Sbjct: 82 LSEILRAPVIPFHRYLPSTHEKTLLALRTLHTRHVIGIPLFPHFTYSVTGSIVRFFM--- 138 Query: 316 REDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIF-FSAHGVPLAYVE 492 +++ + + IP + ++ + I L K +K F FS HG+P+ Y+ Sbjct: 139 ---KHVPEIPISWIPQFGSDSKFVSLITCHIRDFLQKLGILEKECCFLFSVHGLPVRYIS 195 Query: 493 EAGDPYKAEMEECVDLI 543 + GDPY + E I Sbjct: 196 Q-GDPYSKQCYESFSAI 211
>HEMH_ZYMMO (P57779) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 334 Score = 52.4 bits (124), Expect = 1e-06 Identities = 50/184 (27%), Positives = 85/184 (46%), Gaps = 18/184 (9%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASI--GGGSPLRQITDAQGEALMEA 186 +D +I LP F Q L I RAP+S Y I GSPL IT Q + L + Sbjct: 41 SDQRVIELPAV--FWQIILRGIILPFRAPRSARAYQKIWTNEGSPLAAITKKQAQGLQKR 98 Query: 187 LCG-----------KDIPAKIKK---DGITKLVVLPLYPQFSISTSGSSLRLLESIFRED 324 + I ++++K G ++++ PLYPQ+S +++ + ++ Sbjct: 99 MPNITVDYAMRYGTPSISSRLEKLIASGCRRILLAPLYPQYSAASTATVQDEAYRYLQKI 158 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKEL--LKFPKPQKVMIFFSAHGVPLAYVEEA 498 + N++ + +Y YI+ + IE ++ L F KP +++ S HG+P+ E Sbjct: 159 RWQPNLRS--LEPYYTHPAYIQTLKKNIEDQIKALDF-KPDSLLL--SYHGMPVK-TREL 212 Query: 499 GDPY 510 GDPY Sbjct: 213 GDPY 216
>HEMH_XYLFA (Q9PFU1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 51.6 bits (122), Expect = 2e-06 Identities = 50/183 (27%), Positives = 80/183 (43%), Gaps = 17/183 (9%) Frame = +1 Query: 61 KPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDI--------P 207 KPL + + R P+S YA + GSPL T E L + L + P Sbjct: 47 KPLLHMVILPIRGPRSASKYAKVWLQEGSPLSVYTRRIAEGLTQHLPDWRVAWAMRYGAP 106 Query: 208 AKIKK------DGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWY 369 A K + ++V+LPLYPQ+S +T+ S ++E+ + +Q I + Sbjct: 107 ALTKALDALQAQQVRRIVILPLYPQYSTTTTASVQDVVEAWCKRTP---QVQVECIQDYA 163 Query: 370 QREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIME 549 + ++ A+A I + + +K+M FS HG+P V GDPY + LI Sbjct: 164 EDSAWVAAVAASIRRHWQAHGRSEKLM--FSFHGLP-QRVANNGDPYPQRCQVSASLIAA 220 Query: 550 ELE 558 L+ Sbjct: 221 ALD 223
>HEMH_LEGPL (Q5WZB4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 331 Score = 51.2 bits (121), Expect = 2e-06 Identities = 49/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGG--GSPLRQITDAQGEALMEAL 189 D +I LP R++ + I R+PKS + Y SI GSPL + L AL Sbjct: 31 DKRVIDLPTIPRYIL--VYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQNLVTKLQSAL 88 Query: 190 CGKD-----IPAKIKKDGIT----------KLVVLPLYPQFSISTSGSSLRLLESIFRED 324 KD + + IT L +LPL+PQ+S + +GS++ S Sbjct: 89 --KDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSYLANQ 146 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAG 501 E + +++ +I +YQR YI+A A +++ + + FS HG+P ++ ++G Sbjct: 147 EIIPSIK--IIRDFYQRPEYIQAQAKIMKPYI-----KDNFHVLFSYHGIPERHIHKSG 198
>HEMH_PSEFL (P57778) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 340 Score = 51.2 bits (121), Expect = 2e-06 Identities = 47/184 (25%), Positives = 84/184 (45%), Gaps = 16/184 (8%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASI--GGGSPL--------RQITD-- 159 DP +I LP +R L L I + R +S YASI GSPL +Q+T Sbjct: 32 DPYVIDLPWPVRRL---LVSLILIKRPAQSAHAYASIWWDEGSPLVVLSRRLQQQMTAQW 88 Query: 160 AQGEALMEALCGK----DIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDE 327 QG + G+ + ++ GI+K+ + PLYPQF+ ST + + + R+ + Sbjct: 89 TQGPVELAMRYGEPSIESVLTRLAGQGISKVTLAPLYPQFADSTVTTVIEEARRVVRDKQ 148 Query: 328 YLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDP 507 +++Q +++ +Y + Y+ A+ L + + FS HG+P ++ + Sbjct: 149 --LDLQFSILQPFYDQPEYLDALVASARPHL----QQDYDHLLFSFHGLPERHLNKLNPG 202 Query: 508 YKAE 519 + E Sbjct: 203 HSLE 206
>HEMH_CHLMU (Q9PJQ6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 317 Score = 51.2 bits (121), Expect = 2e-06 Identities = 48/200 (24%), Positives = 88/200 (44%), Gaps = 16/200 (8%) Frame = +1 Query: 7 LFADPDII--RLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALM 180 L D D+ R+P +L +PL +I+ RA + E YA +GG SP+ Q T+ + L Sbjct: 25 LLTDQDVTGGRIPP---WLHRPLFSYIAKRRAHRVAEQYAYLGGRSPIFQDTEKLAQNLS 81 Query: 181 EAL-------------CGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 + L +D A + ++ ++ +PL+P ++ + +GS +R E Sbjct: 82 QELQAPVISFHRYLTETHQDTLAAL-RESAGDIIGIPLFPHYTFAVTGSIIRFFLERIPE 140 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELL-KFPKPQKVMIFFSAHGVPLAYVEEA 498 V P +I M I+ L+ + + FS HG+P+ ++ Sbjct: 141 KPMAWITHFGVHPQ------FISCMREHIQDCLIAQGIVAEDCFFLFSVHGLPMRHI-RL 193 Query: 499 GDPYKAEMEECVDLIMEELE 558 GDPY + ++ + ++ E E Sbjct: 194 GDPYAKQCQDSFNALIGESE 213
>HEMH_WIGBR (Q8D226) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 321 Score = 50.8 bits (120), Expect = 3e-06 Identities = 33/118 (27%), Positives = 59/118 (50%) Frame = +1 Query: 202 IPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREG 381 I IK + KL++LP+YPQ+S +T+ S L + + ++ + ++ I + Sbjct: 110 IKKMIKIYNVNKLIILPMYPQYSCTTTASVLDSVCEVIKKYRNIPSI--IFIRDYADNIN 167 Query: 382 YIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 YI A+ I+K K P+ M+ S HG+P Y+++ GD Y L++ +L Sbjct: 168 YINAITNSIKKSFNKNGIPE--MLIMSFHGIPKKYIKD-GDDYLKRCNVTKKLVLSKL 222
>HEMH_SALTI (Q8Z8T2) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 50.8 bits (120), Expect = 3e-06 Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 19/205 (9%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVA-RAPKSKEGYASI--GGGSPLRQITDAQGEALME 183 +D ++ PR L + PL + + + R+P+ + Y SI GGSPL + Q +AL Sbjct: 33 SDRRVVDTPRLLWW---PLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYSREQQQALAA 89 Query: 184 ALCGKDIPA----------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIF 315 L D P ++ + +VVLPLYPQ+S ST G+ L I Sbjct: 90 RL--PDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRIL 147 Query: 316 REDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 + + + I + YI A+A + + +P ++ S HG+P Y +E Sbjct: 148 ARKRRIPGI--SFIRDYADDGAYIDALAKSARESFARHGEPD--LLLLSYHGIPQRYADE 203 Query: 496 AGDPYKAEMEECVDLIMEELEKRGM 570 GD Y + C D E + G+ Sbjct: 204 -GDDYP---QRCRDTTRELVSALGL 224
>HEMH_THET2 (Q72L32) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 317 Score = 50.8 bits (120), Expect = 3e-06 Identities = 30/116 (25%), Positives = 59/116 (50%) Frame = +1 Query: 208 AKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYI 387 A + +DG+ + V + P +S+ + ++S + ++ + S+ G I Sbjct: 107 AAMHEDGVRRAVAIVAAPHYSLRSVAEYREKVDSALKTLPEPIDF--VWVESYEAHPGLI 164 Query: 388 KAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 A A +E+ + + P K F+AH +PL+ VE+ GDPY ++E+ +LI ++L Sbjct: 165 AAYARRLEEVIWRLKNPGKAAYVFTAHSIPLSAVEK-GDPYPRQVEKTAELIAKKL 219
>HEMH_XYLFT (Q87B82) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 50.4 bits (119), Expect = 4e-06 Identities = 50/182 (27%), Positives = 79/182 (43%), Gaps = 17/182 (9%) Frame = +1 Query: 61 KPLAQFISVA-RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDI--------P 207 KPL + + R P+S YA + GSPL T E L + L + P Sbjct: 47 KPLLHMVILPIRGPRSASKYAKVWLQEGSPLSVYTRRIAEGLTQHLPDWRVAWAMRYGAP 106 Query: 208 AKIKK------DGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWY 369 A K + ++V+LPLYPQ+S +T+ S ++E+ + +Q I + Sbjct: 107 ALTKALDALQAQQVRRIVILPLYPQYSTTTTASVQDVVEAWCKRTP---QVQVECIQDYA 163 Query: 370 QREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIME 549 + ++ A+A I + + +K+M FS HG+P V GDPY + LI Sbjct: 164 EDPAWVAAVAASIRRHWQAHGRSEKLM--FSFHGLP-QRVANNGDPYPQRCQVSASLIAA 220 Query: 550 EL 555 L Sbjct: 221 AL 222
>HEMH_SALTY (P37408) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 50.4 bits (119), Expect = 4e-06 Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 19/205 (9%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVA-RAPKSKEGYASI--GGGSPLRQITDAQGEALME 183 +D ++ PR L + PL + + + R+P+ + Y SI GGSPL + Q +AL Sbjct: 33 SDRRVVDTPRLLWW---PLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYSREQQQALAA 89 Query: 184 ALCGKDIPA----------------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIF 315 L D P ++ + +VVLPLYPQ+S ST G+ L I Sbjct: 90 RL--PDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRIL 147 Query: 316 REDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 + + + I + YI A+A + + +P ++ S HG+P Y +E Sbjct: 148 ARKRRIPGI--SFIRDYADDGAYIDALAKSARESFARHGEPD--VLLLSYHGIPQRYADE 203 Query: 496 AGDPYKAEMEECVDLIMEELEKRGM 570 GD Y + C D E + G+ Sbjct: 204 -GDDYP---QRCRDTTRELVSALGL 224
>HEMH_VIBVY (Q7MMR4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 319 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/115 (29%), Positives = 59/115 (51%) Frame = +1 Query: 211 KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIK 390 K++ G+ ++ VLPLYPQ+S +T+G++ L R+ + ++Q I ++ YIK Sbjct: 113 KLQAQGVDEICVLPLYPQYSGTTTGAAYDALAHALRKVAVVPSIQ--FIRDYHDHPLYIK 170 Query: 391 AMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 A+A + + K ++ S HG+P Y + GD Y E +L+ EL Sbjct: 171 ALAESVRQSWQAQGKGDYLLC--SYHGIPQRYADN-GDIYPLHCEMTTELLRLEL 222
>HEMH_VIBVU (Q8DFM2) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 319 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/115 (29%), Positives = 59/115 (51%) Frame = +1 Query: 211 KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIK 390 K++ G+ ++ VLPLYPQ+S +T+G++ L R+ + ++Q I ++ YIK Sbjct: 113 KLQAQGVDEICVLPLYPQYSGTTTGAAYDALAHALRKVAVVPSIQ--FIRDYHDHPLYIK 170 Query: 391 AMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 A+A + + K ++ S HG+P Y + GD Y E +L+ EL Sbjct: 171 ALAESVRQSWQVQGKGDYLLC--SYHGIPQRYADN-GDVYPLHCEMTTELLRLEL 222
>HEMH_LEGPH (Q5ZYE7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 331 Score = 50.1 bits (118), Expect = 5e-06 Identities = 49/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGG--GSPLRQITDAQGEALMEAL 189 D +I LP R++ + I R+PKS + Y SI GSPL + L AL Sbjct: 31 DKRVIDLPTIPRYIL--VYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQNLVTKLQSAL 88 Query: 190 CGKD-----IPAKIKKDGIT----------KLVVLPLYPQFSISTSGSSLRLLESIFRED 324 KD + + IT L +LPL+PQ+S + +GS++ S Sbjct: 89 --KDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSHLANQ 146 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAG 501 E + +++ +I +YQR YI+A A +++ + + FS HG+P ++ ++G Sbjct: 147 EIIPSIK--IIRDFYQRPEYIQAQAKIMKPYI-----KDNFHLLFSYHGIPERHIHKSG 198
>HEMH_LEGPA (Q5X7W3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 331 Score = 50.1 bits (118), Expect = 5e-06 Identities = 48/179 (26%), Positives = 82/179 (45%), Gaps = 17/179 (9%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGG--GSPLRQITDAQGEALMEAL 189 D +I LP R++ + I R+PKS + Y SI GSPL + L +L Sbjct: 31 DKRVIDLPTIPRYIL--VYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQNLVTKLQSSL 88 Query: 190 CGKD-----IPAKIKKDGIT----------KLVVLPLYPQFSISTSGSSLRLLESIFRED 324 KD + + IT L +LPL+PQ+S + +GS++ S Sbjct: 89 --KDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSYLANQ 146 Query: 325 EYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAG 501 E + +++ +I +YQR YI+A A +++ + + FS HG+P ++ ++G Sbjct: 147 EIIPSIK--IIRDFYQRPEYIQAQAKIMKPYI-----KDNFHVLFSYHGIPERHIHKSG 198
>HEMH_RALSO (Q8XW32) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 371 Score = 49.3 bits (116), Expect = 8e-06 Identities = 51/196 (26%), Positives = 92/196 (46%), Gaps = 30/196 (15%) Frame = +1 Query: 13 ADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIG------GGSPL---------- 144 +DP ++ +PRA + L I R+ S Y ++ GSPL Sbjct: 44 SDPRVVEIPRAAWWFI--LNVLILPLRSRASAHKYETVWLREANMTGSPLLVYSERQAHA 101 Query: 145 -RQITDAQGEALMEALCGK----DIPA---KIKKDGITKLVVLPLYPQFSISTSGSSLRL 300 +Q+ DAQG ++ A + IP+ ++K G+ +++VLP+YPQ+S +T+ ++ Sbjct: 102 LQQLLDAQGHDVVVACAMRYGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATA--- 158 Query: 301 LESIFREDEYLVNM-QHTVIPSWYQREGYIKAM-----ATLIEKELLKFPKPQKVMIFFS 462 + +FR + N + ++ ++ YI A+ A + F + K+++ F Sbjct: 159 FDEVFRVMGQMRNQPELRLVKHFHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSF- 217 Query: 463 AHGVPLAYVEEAGDPY 510 HGVP + E GDPY Sbjct: 218 -HGVPRRTL-ELGDPY 231
>HEMH_PSEPK (Q88PV4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 338 Score = 49.3 bits (116), Expect = 8e-06 Identities = 48/178 (26%), Positives = 80/178 (44%), Gaps = 18/178 (10%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGG--GSPLRQITDAQGEALME-- 183 DP +I LP +R L L + + R +S YASI GSPL +T A+ E Sbjct: 32 DPYVIDLPWPVRRL---LVSLVLIKRPEQSAHAYASIWWEEGSPLVVLTRRLQAAMAEHW 88 Query: 184 --------------ALCGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 AL D+ A++ G+ K+ + PLYPQF+ ST + + + Sbjct: 89 PHGPVEIAMRYGQPAL--PDVLARLAAQGVRKVTLAPLYPQFADSTVTTVIEQAKQTV-- 144 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 E+ + +Q V+ +Y+ YI+A+A L + + S HG+P ++++ Sbjct: 145 SEHQLPLQMRVLQPFYEHPAYIEALAASARPYL----EQGYDHLLLSFHGLPERHLKK 198
>HEMH_PSESM (Q888A2) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 340 Score = 47.8 bits (112), Expect = 2e-05 Identities = 43/170 (25%), Positives = 76/170 (44%), Gaps = 16/170 (9%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASI--GGGSPLRQITDAQGEALMEAL 189 DP +I +P LR L L I + R +S YASI GSPL ++ +A+ + Sbjct: 32 DPYVIDIPWPLRRL---LVSLILIKRPEQSAHAYASIWWDEGSPLVVLSKRLQQAMKKEW 88 Query: 190 CG--------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDE 327 + + ++ + G K+ + PLYPQF+ ST + + + + R Sbjct: 89 SHGPVELAMRYGEPSIETVLTRLSEQGFKKVTLAPLYPQFADSTVTTVIEEAKRVVRAKS 148 Query: 328 YLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVP 477 + MQ +V+ +Y + Y+ A+ + L +P ++ S HG+P Sbjct: 149 --LKMQFSVLQPFYDQPEYVSALVESVRPHL---EQPYDHLL-LSFHGLP 192
>HEMH_VIBCH (Q9KTB6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 47.4 bits (111), Expect = 3e-05 Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%) Frame = +1 Query: 49 RFLQKPLAQFISV-ARAPKSKEGYASI--GGGSPLRQITDAQGEALMEALCGKDIPA--- 210 R+L PL I + R+PK + Y SI GSPL + Q + L E L + + Sbjct: 43 RWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSPLMVYSRRQRDKLAE-LSQRPVELGMT 101 Query: 211 -----------KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVI 357 K+++ G+ ++VVLPLYPQ+S +T+ + L R+ + + I Sbjct: 102 YGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPELH--FI 159 Query: 358 PSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVD 537 ++ YI+A+A + + Q ++ S HG+P Y + GD Y + + Sbjct: 160 RDYHDHPLYIQALAKSVRASWQQ--HGQGDLLLCSYHGIPKRYAQN-GDIYPEHCLKTTE 216 Query: 538 LIMEEL 555 L+ + L Sbjct: 217 LLAQAL 222
>HEMH_GEOKA (Q5L283) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 316 Score = 46.6 bits (109), Expect = 5e-05 Identities = 47/203 (23%), Positives = 85/203 (41%), Gaps = 22/203 (10%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + + DI R +R +KP + I +A Y +IGG SPL +IT+ Q + L E L Sbjct: 17 YREDDIERYYTHIRHGRKPPQEQIEDLKAR-----YRAIGGLSPLAKITEEQAKRLEERL 71 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +D ++ DGI + V + L P +S + S ++ Sbjct: 72 NEVQDEVEFRMYLGLKHIEPFIEDAVERMHDDGIKEAVGIVLAPHYSTFSIRSYNERAKA 131 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP--KPQKVMIFFSAHGVPLA 483 ++ L I WY +++ A + P + ++ ++ SAH +P Sbjct: 132 AAKK---LGGPTIYTIDQWYDEPKFLQYWAEQVRAIFAAMPERERERAVLIVSAHSLPEK 188 Query: 484 YVEEAGDPYKAEMEECVDLIMEE 552 + +AGDPY ++E+ I ++ Sbjct: 189 II-QAGDPYPTQLEDTAKRIADQ 210
>HEMH1_BACAN (Q81U22) Ferrochelatase 1 (EC 4.99.1.1) (Protoheme ferro-lyase 1)| (Heme synthetase 1) Length = 311 Score = 46.2 bits (108), Expect = 7e-05 Identities = 50/205 (24%), Positives = 82/205 (40%), Gaps = 22/205 (10%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + + DI R +R +KP + + E Y +IGG SPL IT Q + L + L Sbjct: 16 YKEEDIERYYTHIRRGRKPSPEMLE-----DLTERYRAIGGISPLATITLEQAKKLEKRL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +D ++ DGI + L L P +S + S + + Sbjct: 71 NEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQ- 129 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEK--ELLKFPKPQKVMIFFSAHGVPLA 483 E E L N+ I SWY+ +I+ ++ + + +K ++ SAH +P Sbjct: 130 --EEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKSIYSGMSDAEREKAVLIVSAHSLPEK 187 Query: 484 YVEEAGDPYKAEMEECVDLIMEELE 558 + GDPY ++ E D I E Sbjct: 188 II-AMGDPYPDQLNETADYIARGAE 211
>HEMH_PSEAE (Q9HVD7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 340 Score = 45.8 bits (107), Expect = 9e-05 Identities = 44/176 (25%), Positives = 84/176 (47%), Gaps = 16/176 (9%) Frame = +1 Query: 16 DPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASI--GGGSPL----RQITDAQ---- 165 DP ++ LP LR L L I + R +S Y+SI GSPL R++ +A Sbjct: 32 DPYVVDLPWPLRRL---LVSLILIKRPAESAHAYSSIWWDEGSPLIVLSRRLQEAMKPHW 88 Query: 166 --GEALMEALCGKDIPAKIKKD----GITKLVVLPLYPQFSISTSGSSLRLLESIFREDE 327 G + G+ K+ D GI ++ + PLYPQF+ ST+ ++ + + + Sbjct: 89 PHGPVELAMRYGQPAIEKVLLDLARRGIRRVTLAPLYPQFADSTTTTAEQEVRRVIA--A 146 Query: 328 YLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEE 495 + + ++ + +P +Y + Y+ A+ + + L+ P ++ F HG+P ++ + Sbjct: 147 HRLGLEVSTLPPFYDQPVYLDALVESV-RPYLQQPHDHLLLSF---HGLPERHIRK 198
>HEMH1_BACHK (Q6HM97) Ferrochelatase 1 (EC 4.99.1.1) (Protoheme ferro-lyase 1)| (Heme synthetase 1) Length = 311 Score = 45.4 bits (106), Expect = 1e-04 Identities = 50/205 (24%), Positives = 82/205 (40%), Gaps = 22/205 (10%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + + DI R +R +KP + + E Y +IGG SPL IT Q + L + L Sbjct: 16 YKEEDIERYYTHIRRGRKPSPEMLE-----DLTERYRAIGGISPLATITLEQAKKLEKRL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +D ++ DGI + L L P +S + S + + Sbjct: 71 NEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQ- 129 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIE--KELLKFPKPQKVMIFFSAHGVPLA 483 E E L N+ I SWY+ +I+ ++ + + +K ++ SAH +P Sbjct: 130 --EEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYSGMSDAEREKAVLIVSAHSLPEK 187 Query: 484 YVEEAGDPYKAEMEECVDLIMEELE 558 + GDPY ++ E D I E Sbjct: 188 II-AMGDPYPDQLNETADYIARGAE 211
>HEMH1_BACCZ (Q63ES4) Ferrochelatase 1 (EC 4.99.1.1) (Protoheme ferro-lyase 1)| (Heme synthetase 1) Length = 311 Score = 45.4 bits (106), Expect = 1e-04 Identities = 50/205 (24%), Positives = 82/205 (40%), Gaps = 22/205 (10%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + + DI R +R +KP + + E Y +IGG SPL IT Q + L + L Sbjct: 16 YKEEDIERYYTHIRRGRKPSPEMLE-----DLTERYRAIGGISPLATITLEQAKKLEKRL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +D ++ DGI + L L P +S + S + + Sbjct: 71 NEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQ- 129 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIE--KELLKFPKPQKVMIFFSAHGVPLA 483 E E L N+ I SWY+ +I+ ++ + + +K ++ SAH +P Sbjct: 130 --EEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVSAHSLPEK 187 Query: 484 YVEEAGDPYKAEMEECVDLIMEELE 558 + GDPY ++ E D I E Sbjct: 188 II-AMGDPYPDQLNETADYIARGAE 211
>HEMH1_BACC1 (Q73C98) Ferrochelatase 1 (EC 4.99.1.1) (Protoheme ferro-lyase 1)| (Heme synthetase 1) Length = 311 Score = 45.1 bits (105), Expect = 2e-04 Identities = 50/205 (24%), Positives = 81/205 (39%), Gaps = 22/205 (10%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + + DI R +R +KP + + E Y +IGG SPL IT Q + L + L Sbjct: 16 YKEEDIERYYTHIRRGRKPSPEMLE-----DLTERYRAIGGISPLATITLEQAKKLEKRL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +D + DGI + L L P +S + S + + Sbjct: 71 NEVQDEVEYHMYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQ- 129 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIE--KELLKFPKPQKVMIFFSAHGVPLA 483 E E L N+ I SWY+ +I+ ++ + + +K ++ SAH +P Sbjct: 130 --EEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVSAHSLPEK 187 Query: 484 YVEEAGDPYKAEMEECVDLIMEELE 558 + GDPY ++ E D I E Sbjct: 188 II-AMGDPYPEQLHETADYIARGAE 211
>HEMH1_BACCR (Q81GW5) Ferrochelatase 1 (EC 4.99.1.1) (Protoheme ferro-lyase 1)| (Heme synthetase 1) Length = 311 Score = 44.7 bits (104), Expect = 2e-04 Identities = 50/205 (24%), Positives = 81/205 (39%), Gaps = 22/205 (10%) Frame = +1 Query: 10 FADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEAL 189 + + DI R +R +KP + + E Y +IGG SPL IT Q + L + L Sbjct: 16 YKEEDIERYYTHIRRGRKPSPEMLE-----DLTERYRAIGGISPLATITLEQAKKLEKRL 70 Query: 190 CG--------------------KDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLES 309 +D + DGI + L L P +S + S + + Sbjct: 71 NEVQDEVEYHMYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQ- 129 Query: 310 IFREDEYLVNMQHTVIPSWYQREGYIKAMATLIE--KELLKFPKPQKVMIFFSAHGVPLA 483 E E L N+ I SWY+ +I+ ++ + + +K ++ SAH +P Sbjct: 130 --EEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVSAHSLPEK 187 Query: 484 YVEEAGDPYKAEMEECVDLIMEELE 558 + GDPY ++ E D I E Sbjct: 188 II-AMGDPYPDQLNETADYIARGAE 211
>HEMH_VIBPA (Q87RH3) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 43.9 bits (102), Expect = 3e-04 Identities = 44/173 (25%), Positives = 77/173 (44%), Gaps = 18/173 (10%) Frame = +1 Query: 91 RAPKSKEGYASIG--GGSPLRQITDAQGEALMEALCGKDIPAKIKK-------------- 222 R+PK + Y S+ GSPL + Q + L + L D+P ++ Sbjct: 58 RSPKVAKLYESVWMEEGSPLMVYSKRQAKKLAQHL---DMPVELGMTYGNPSLQSGFEAL 114 Query: 223 --DGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAM 396 G+ +++VLPLYPQ+S +T+ + + F+ + V + I ++ YI+A+ Sbjct: 115 IAQGVEEVIVLPLYPQYSGTTTAAVSDGITKAFK--QLPVMPAFSFIRDYHDHPMYIEAL 172 Query: 397 ATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEEL 555 A + + + K ++ S HG+P Y + GD Y E L+ E L Sbjct: 173 AHSVRQYWEEHGKGDYLLC--SYHGIPKRYADN-GDIYPQHCEATTRLLGEAL 222
>HEMH_SYMTH (Q67T48) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 320 Score = 40.4 bits (93), Expect = 0.004 Identities = 48/209 (22%), Positives = 87/209 (41%), Gaps = 31/209 (14%) Frame = +1 Query: 16 DPDIIRLPRALRFL------QKPLAQFISV-------ARAPKSKEGYASIG--GGSPLRQ 150 +PD +R P FL KP Q++ + R P+ + Y I GSPL Sbjct: 18 EPDAVR-PYLAEFLGDWWVIDKPRWQWLPILHGIILRVRPPRVAKIYQKIWLPEGSPLLH 76 Query: 151 ITDAQGEALMEALCGKDIPA----------------KIKKDGITKLVVLPLYPQFSISTS 282 + Q AL + L + I +++ G+ +L+VLPL+PQ+S +T+ Sbjct: 77 YSRLQQAALQQRLEPEGIRVALGMTYGQPSVKSALEELRGWGVRRLLVLPLFPQYSSTTT 136 Query: 283 GSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFS 462 + ++ D + + I + Y+ + I + + +P +++ S Sbjct: 137 AAVWSKVQKAL--DGWRDLPEQIFIRDFPTHPKYLAFLTERISGYIAEKGRPDALVL--S 192 Query: 463 AHGVPLAYVEEAGDPYKAEMEECVDLIME 549 H +P AY +GD Y A+ E D + + Sbjct: 193 YHSIPQAYT-ASGDDYAAQCESTTDAVRD 220
>HEMH_PORGI (Q7MXP4) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 345 Score = 40.0 bits (92), Expect = 0.005 Identities = 48/179 (26%), Positives = 77/179 (43%), Gaps = 15/179 (8%) Frame = +1 Query: 4 NLFADPDIIRLPRALRFLQKPLAQFISVARAPKSKEGYASIGGGS----PLRQITDAQGE 171 + D II LP LR Q + I+ R S + Y ++ S PL T A Sbjct: 39 SFLTDRRIITLPFLLR--QLLVRGIITPFRKKSSAQKYRTVWDESTRSFPLISHTKAIAR 96 Query: 172 ALMEA--------LCGKDIPAKIKKD--GITKLVVLPLYPQFSISTSGSSLRLLESIFRE 321 AL GK A + K+ LVVLPL+P +++S+ +++ ++ R Sbjct: 97 ALAHTGREVHVAMRYGKPAVADVLKELPHGRSLVVLPLFPHYAMSSYETAVEHCKAEIR- 155 Query: 322 DEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLK-FPKPQKVMIFFSAHGVPLAYVEE 495 N+ V+ +Y E YI+ +A I L K F K + S HG+P ++++ Sbjct: 156 -RLCPNLSFRVVQPFYAHEAYIRVLADNIRPYLTKPFDK-----LILSYHGIPRDHLDK 208
>HEMH_PROFR (P72183) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 352 Score = 39.7 bits (91), Expect = 0.007 Identities = 52/197 (26%), Positives = 74/197 (37%), Gaps = 24/197 (12%) Frame = +1 Query: 52 FLQKPLAQFISVARAPKSKEGYASIGGGSPLRQITDAQGEALMEALC--GKDIP------ 207 FLQ+ I R + + YA GG SP+ A AL EAL G D+P Sbjct: 24 FLQRVSGGHIPPDRLAEVEHHYARFGGVSPVNAQHRALAAALGEALVARGIDVPIANANR 83 Query: 208 ----------AKIKKDGITKLVVLPLYPQFSISTSGSSL---RLLESIFREDEYLVNMQH 348 A ++ GI + VL L P S SG LL +DE +Q Sbjct: 84 HSMPYMDQALADLQSRGIRR--VLTLVPTPYASYSGCRAYREELLAGTRIDDEGRPALQV 141 Query: 349 TVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEA---GDPYKAE 519 + + + A L+ L P V F+ H +P A E + G+ Y + Sbjct: 142 VKLDPYADLPALVTAQVQLLRAALADHPDAHLV---FTTHSIPTAMAETSGPHGNAYIPQ 198 Query: 520 MEECVDLIMEELEKRGM 570 +D +M EL G+ Sbjct: 199 HLALIDAVMAELAALGL 215
>HEMH_CORGL (Q8NQA1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 370 Score = 34.3 bits (77), Expect = 0.27 Identities = 20/74 (27%), Positives = 33/74 (44%), Gaps = 7/74 (9%) Frame = +1 Query: 349 TVIPSWYQREGYIKAMATLIEKELLKFPKP--QKVMIFFSAHGVPLAYVEEAGDP----- 507 T + +Y ++ MA L++ K P + + F+AH +PL AG P Sbjct: 148 TKLRQFYDHPRFVSTMAQLVQDSYAKLPDELRDEARLVFTAHSIPLTADNAAGTPEDGSL 207 Query: 508 YKAEMEECVDLIME 549 Y +++E LI E Sbjct: 208 YSTQVKEASALIAE 221
>HEMH_PARUW (Q6MAW8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 347 Score = 34.3 bits (77), Expect = 0.27 Identities = 24/114 (21%), Positives = 51/114 (44%) Frame = +1 Query: 211 KIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIK 390 ++K + ++V+ PL+PQ++ +T+GS + + ++ + + + T I S+ G + Sbjct: 113 RLKLANVKEIVIFPLFPQYASATTGSVHQEVMKHLQQWQNIPTL--TFINSYPDHPGLVG 170 Query: 391 AMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEE 552 A ++ L FS HG+P + + K E C +I + Sbjct: 171 AFCERAKQYDLSIYD----YFLFSFHGLPERQIRKGDSTGKCLTENCCQVICSD 220
>HEMH_COREF (Q8FTB1) Ferrochelatase (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme| synthetase) Length = 377 Score = 32.7 bits (73), Expect = 0.80 Identities = 19/75 (25%), Positives = 35/75 (46%), Gaps = 7/75 (9%) Frame = +1 Query: 349 TVIPSWYQREGYIKAMATLIEKELLKFPKP--QKVMIFFSAHGVPLAYVEEAGDP----- 507 T + +Y +++ MA + + K P+ + + F+AH +PL + G+P Sbjct: 153 TKLRQFYDHPRFVRTMAQYVRESFDKLPEDLRDEARLVFTAHSIPLNSKDADGNPIDGSI 212 Query: 508 YKAEMEECVDLIMEE 552 Y ++EE LI E Sbjct: 213 YSRQVEESSALIARE 227
>ISPH1_BRAJA (Q89UU5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC| 1.17.1.2) Length = 322 Score = 32.7 bits (73), Expect = 0.80 Identities = 18/55 (32%), Positives = 30/55 (54%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEA 498 V ++H ++ + Y +G K A +E EL + P+ + FSAHGVP + +A Sbjct: 39 VYVRHEIVHNKYVVDGLKKKGAIFVE-ELAEIPESTTAPVVFSAHGVPKSVPADA 92
>ISPH_BARQU (Q6G0C9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC| 1.17.1.2) Length = 340 Score = 31.6 bits (70), Expect = 1.8 Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVM-IFFSAHGVPLAYVEEAGDPY 510 V ++H ++ + Y EG + A +E EL + P+ + + FSAHGVP + E+A D Y Sbjct: 39 VYVRHEIVHNRYVVEGLQQRGAIFVE-ELDEIPEEHRNQPVVFSAHGVPKSVPEQA-DRY 96 Query: 511 KAEMEECVDLIMEELEKRGMEN 576 + ++ ++ K+ M + Sbjct: 97 NLFYLDATCPLVSKVHKQAMRH 118
>TAAR3_HUMAN (Q9P1P4) Trace amine-associated receptor 3 (G-protein coupled| receptor 57) Length = 343 Score = 31.2 bits (69), Expect = 2.3 Identities = 15/46 (32%), Positives = 28/46 (60%) Frame = -3 Query: 573 FHSSFFELLHDKIHALFHLCFIRITSFFNVCQRNSMSTEKYHNLLR 436 FH+SF +L ++ ++FHLC I I F+ VC +T+ ++ ++ Sbjct: 106 FHTSFDMML--RLTSIFHLCSIAIDRFYAVCYPLHYTTKMTNSTIK 149
>ISPH_BARHE (Q6G4C5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC| 1.17.1.2) Length = 343 Score = 31.2 bits (69), Expect = 2.3 Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVM-IFFSAHGVPLAYVEEAGDPY 510 V ++H ++ + Y EG + A +E EL + P+ + + FSAHGVP + E+A D Y Sbjct: 39 VYVRHEIVHNRYVVEGLQQRGAIFVE-ELDEIPEEHRNQPVVFSAHGVPKSVPEQA-DCY 96 Query: 511 KAEMEECVDLIMEELEKRGMEN 576 + ++ ++ K+ M + Sbjct: 97 NLFYLDATCPLVSKVHKQAMRH 118
>ISPH_AGRT5 (P58673) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC| 1.17.1.2) Length = 348 Score = 31.2 bits (69), Expect = 2.3 Identities = 18/56 (32%), Positives = 32/56 (57%), Gaps = 1/56 (1%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVM-IFFSAHGVPLAYVEEA 498 V ++H ++ + Y EG ++A + +EL + P + + FSAHGVP + E+A Sbjct: 42 VYVRHEIVHNRYVVEG-LEAKGAIFVEELHEIPAEHREQPVVFSAHGVPKSVPEDA 96
>ISPH_GLUOX (Q5FUH7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC| 1.17.1.2) Length = 336 Score = 30.8 bits (68), Expect = 3.0 Identities = 22/70 (31%), Positives = 38/70 (54%) Frame = +1 Query: 289 SLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAH 468 ++R++E R V ++H ++ + EG ++A + +EL + P+ V+ FSAH Sbjct: 38 AIRVVEEALRRYGAPVYVRHEIVHNRTVVEG-LEAKGAIFVEELDEVPEDGHVV--FSAH 94 Query: 469 GVPLAYVEEA 498 GVP A EA Sbjct: 95 GVPKAVPAEA 104
>GCY3E_DROME (Q07553) Guanylate cyclase 32E precursor (EC 4.6.1.2)| Length = 1163 Score = 30.8 bits (68), Expect = 3.0 Identities = 19/73 (26%), Positives = 35/73 (47%) Frame = +1 Query: 367 YQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIM 546 Y EG ++ L+ +E K + M+ + P+A + + GDP +AE +CV ++ Sbjct: 822 YNLEGLVQERTNLLYEE-----KKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILF 876 Query: 547 EELEKRGMENPCT 585 ++ G CT Sbjct: 877 SDIV--GFTELCT 887
>LCRD_YEREN (P21210) Low calcium response locus protein D| Length = 704 Score = 30.4 bits (67), Expect = 4.0 Identities = 23/98 (23%), Positives = 42/98 (42%) Frame = +1 Query: 139 PLRQITDAQGEALMEALCGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFR 318 PL D+ + +EA+ D ++++ LY + G LR E + Sbjct: 372 PLLIDVDSSQQEALEAIALNDELVRVRR---------ALYLDLGVPFPGIHLRFNEGM-G 421 Query: 319 EDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP 432 E EYL+++Q + + GY+ ++ + ELL P Sbjct: 422 EGEYLISLQEVPVARGELKAGYLLVRESVSQLELLGIP 459
>TAAR3_MOUSE (Q5QD16) Trace amine-associated receptor 3| Length = 343 Score = 30.4 bits (67), Expect = 4.0 Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 4/51 (7%) Frame = -3 Query: 573 FHSSFFELLHDKIHALFHLCFIRITSFFNVCQ----RNSMSTEKYHNLLRF 433 FH+SF +L + ++FHLC I I F+ VC +M+ LL F Sbjct: 106 FHASFDMML--SLTSIFHLCSIAIDRFYAVCDPLHYTTTMTVSMIKRLLAF 154
>TAAR3_RAT (Q5QD24) Trace amine-associated receptor 3| Length = 342 Score = 30.0 bits (66), Expect = 5.2 Identities = 14/31 (45%), Positives = 20/31 (64%) Frame = -3 Query: 573 FHSSFFELLHDKIHALFHLCFIRITSFFNVC 481 FH+SF +L + ++FHLC I I F+ VC Sbjct: 106 FHASFDMML--SLTSIFHLCSIAIDRFYAVC 134
>ISPH_RHIME (Q92RG2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC| 1.17.1.2) Length = 350 Score = 30.0 bits (66), Expect = 5.2 Identities = 18/58 (31%), Positives = 34/58 (58%), Gaps = 1/58 (1%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFP-KPQKVMIFFSAHGVPLAYVEEAGD 504 V ++H ++ + Y EG ++A + +EL + P + +K + FSAHGVP + +A + Sbjct: 57 VYVRHEIVHNRYVVEG-LEAKGAIFVEELDEIPPEHRKQPVVFSAHGVPKSVPADADE 113
>CCD43_HUMAN (Q96MW1) Coiled-coil domain-containing protein 43| Length = 224 Score = 30.0 bits (66), Expect = 5.2 Identities = 18/62 (29%), Positives = 34/62 (54%), Gaps = 9/62 (14%) Frame = +1 Query: 289 SLRLLESIFREDEYLVNMQHTVIPSWYQ---------REGYIKAMATLIEKELLKFPKPQ 441 +L+ + S F E++ L+N+ ++ W + +E ++A+ATLIEK+ KP+ Sbjct: 59 ALQGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQAIATLIEKQAQIVVKPR 118 Query: 442 KV 447 V Sbjct: 119 MV 120
>ISPH_AZOSE (Q5P224) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC| 1.17.1.2) Length = 312 Score = 30.0 bits (66), Expect = 5.2 Identities = 19/55 (34%), Positives = 32/55 (58%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEA 498 + ++H V+ + + +G ++A + +EL + P Q V+ FSAHGVP A EA Sbjct: 36 IYVRHEVVHNKFVVDG-LRAKGAIFVEELDEVPTGQTVI--FSAHGVPQAVRSEA 87
>LCRD_YERPS (P69956) Low calcium response locus protein D| Length = 704 Score = 29.6 bits (65), Expect = 6.7 Identities = 22/98 (22%), Positives = 42/98 (42%) Frame = +1 Query: 139 PLRQITDAQGEALMEALCGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFR 318 PL D+ + +EA+ D ++++ LY + G LR E + Sbjct: 372 PLLIDVDSSQQEALEAIALNDELVRVRR---------ALYLDLGVPFPGIHLRFNEGM-G 421 Query: 319 EDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP 432 E EY++++Q + + GY+ ++ + ELL P Sbjct: 422 EGEYIISLQEVPVARGELKAGYLLVRESVSQLELLGIP 459
>LCRD_YERPE (P69955) Low calcium response locus protein D| Length = 704 Score = 29.6 bits (65), Expect = 6.7 Identities = 22/98 (22%), Positives = 42/98 (42%) Frame = +1 Query: 139 PLRQITDAQGEALMEALCGKDIPAKIKKDGITKLVVLPLYPQFSISTSGSSLRLLESIFR 318 PL D+ + +EA+ D ++++ LY + G LR E + Sbjct: 372 PLLIDVDSSQQEALEAIALNDELVRVRR---------ALYLDLGVPFPGIHLRFNEGM-G 421 Query: 319 EDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELLKFP 432 E EY++++Q + + GY+ ++ + ELL P Sbjct: 422 EGEYIISLQEVPVARGELKAGYLLVRESVSQLELLGIP 459
>ISPH1_RHOPA (Q6N3G0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC| 1.17.1.2) Length = 306 Score = 29.3 bits (64), Expect = 8.8 Identities = 19/55 (34%), Positives = 30/55 (54%) Frame = +1 Query: 334 VNMQHTVIPSWYQREGYIKAMATLIEKELLKFPKPQKVMIFFSAHGVPLAYVEEA 498 V ++H ++ + Y E +KA + +EL + P K + FSAHGV + EEA Sbjct: 31 VYVRHEIVHNKYVVES-LKAKGAIFVEELSEVPP--KAVTVFSAHGVARSIEEEA 82 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 91,192,314 Number of Sequences: 219361 Number of extensions: 2027277 Number of successful extensions: 5699 Number of sequences better than 10.0: 156 Number of HSP's better than 10.0 without gapping: 5412 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5564 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 5101629520 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
