ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal2m10 |
|---|---|
| Clone Library Name | barley_pub |
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 65.5 bits (158), Expect = 1e-10 Identities = 44/110 (40%), Positives = 63/110 (57%), Gaps = 12/110 (10%) Frame = +1 Query: 232 QHKSSGI-------ESTPA----EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR 378 QH S+G+ ST A ++ +L G+ +K +++ +KELGSG +G V GKW+ Sbjct: 378 QHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWK 437 Query: 379 G-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 G DVA+K IK +G SE E F++EAQ + L HP +V FYGV Sbjct: 438 GQYDVAVKMIK----EGSMSEDE-----FFQEAQTMMKLSHPKLVKFYGV 478
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 63.2 bits (152), Expect = 5e-10 Identities = 43/110 (39%), Positives = 62/110 (56%), Gaps = 12/110 (10%) Frame = +1 Query: 232 QHKSSGI-------ESTPAE----AEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR 378 QH S+G+ ST A + AL G+ +K +++ +KELG+G +G V G+W+ Sbjct: 354 QHNSAGMITRLRHPVSTKANKVPVSVALGSGIWELKREEITLLKELGNGQFGVVQLGQWK 413 Query: 379 G-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 G DVA+K IK +G SE E F++EAQ + L HP +V FYGV Sbjct: 414 GQYDVAVKMIK----EGAMSEDE-----FFQEAQTMMKLSHPKLVKFYGV 454
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/139 (28%), Positives = 63/139 (45%) Frame = +1 Query: 154 DNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKE 333 D+ G D N D + D+ D K ++ + I D++ K+ Sbjct: 1316 DDTDSGTADDSNYDSGKIIDIDYMADIDKEDSFLTSANMCRWI------INYDEISIGKQ 1369 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +G G+YG VF+GKW+G DVA+K+ + E + +F E LS L H N+V+ Sbjct: 1370 IGLGSYGIVFNGKWKGVDVAVKKFV------KQKLSETQLLEFRAEMAFLSELKHSNIVT 1423 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G P ++ VTE+ Sbjct: 1424 FIGACIKKP--NICIVTEY 1440 Score = 51.6 bits (122), Expect = 2e-06 Identities = 37/103 (35%), Positives = 53/103 (51%), Gaps = 6/103 (5%) Frame = +1 Query: 280 LSKGLQTIKND------DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSER 441 L K T ND +LE + LG+G YG V+ W+G +VA+K I +S + ER Sbjct: 768 LLKHRNTTNNDWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLI-SSKHVSKDMER 826 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F++E +I++SL HPNVV F P ++ V EF Sbjct: 827 -----SFFEEVKIMTSLRHPNVVLFMAASTKSP--NMCIVMEF 862
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 57.8 bits (138), Expect = 2e-08 Identities = 43/111 (38%), Positives = 59/111 (53%), Gaps = 13/111 (11%) Frame = +1 Query: 232 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 375 QH S+G+ ++ P+ A L G I DL +KELG+G +G V +GKW Sbjct: 362 QHNSAGLISRLKYPVSQQNKNAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 420 Query: 376 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 RG DVAIK IK +G SE E F +EA+++ +L H +V YGV Sbjct: 421 RGQYDVAIKMIK----EGSMSEDE-----FIEEAKVMMNLSHEKLVQLYGV 462
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 57.4 bits (137), Expect = 3e-08 Identities = 41/124 (33%), Positives = 65/124 (52%), Gaps = 14/124 (11%) Frame = +1 Query: 241 SSGIESTPAEAEALSKGLQTIKN-------DDLE------EIKE-LGSGTYGSVFHGKWR 378 S+ IE+ P A +S+ + N DD++ IKE +G+G++G+V +W Sbjct: 512 SNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH 571 Query: 379 GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 558 G DVA+K + F +ER + +F +E I+ L HPN+V F G V P +L+ Sbjct: 572 GSDVAVKILMEQDFH---AER---VNEFLREVAIMKRLRHPNIVLFMGAVTQPP--NLSI 623 Query: 559 VTEF 570 VTE+ Sbjct: 624 VTEY 627
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 57.0 bits (136), Expect = 4e-08 Identities = 38/97 (39%), Positives = 52/97 (53%), Gaps = 1/97 (1%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC-DVAIKRIKAS 414 KSS + LS I +L ++ELGSG +G V GKWRG D A+K +K Sbjct: 500 KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK-- 557 Query: 415 CFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 +G SE DF +EA++++ L HPN+V YGV Sbjct: 558 --EGTMSED-----DFIEEAKVMTKLQHPNLVQLYGV 587
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 56.6 bits (135), Expect = 5e-08 Identities = 42/111 (37%), Positives = 59/111 (53%), Gaps = 13/111 (11%) Frame = +1 Query: 232 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 375 QH S+G+ ++ P+ A L G I DL +KELG+G +G V +GKW Sbjct: 362 QHNSAGLISRLKYPVSKQNKNAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 420 Query: 376 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 RG DVAIK I+ +G SE E F +EA+++ +L H +V YGV Sbjct: 421 RGQYDVAIKMIR----EGSMSEDE-----FIEEAKVMMNLSHEKLVQLYGV 462
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 55.1 bits (131), Expect = 1e-07 Identities = 42/111 (37%), Positives = 58/111 (52%), Gaps = 13/111 (11%) Frame = +1 Query: 232 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 375 QH S+G+ +S P+ A L G I DL +KELG+G +G V +GKW Sbjct: 361 QHNSAGLISRLKYPVSRHQKSAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 419 Query: 376 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 RG +VAIK I+ +G SE E F EA+++ +L H +V YGV Sbjct: 420 RGQYNVAIKMIR----EGSMSEDE-----FIDEAKVMMNLSHEKLVQLYGV 461
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 54.3 bits (129), Expect = 2e-07 Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 2/96 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 +L IK DDL+ + G G++GSV+ KW D VA+K++ Sbjct: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------- 47 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 558 KEA+ILS L H N++ FYGV+ + P+ + T Sbjct: 48 -LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVT 82
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 54.3 bits (129), Expect = 2e-07 Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 2/96 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 +L IK DDL+ + G G++GSV+ KW D VA+K++ Sbjct: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------- 47 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 558 KEA+ILS L H N++ FYGV+ + P+ + T Sbjct: 48 -LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVT 82
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 53.5 bits (127), Expect = 4e-07 Identities = 34/87 (39%), Positives = 43/87 (49%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 ++LE + +G G +G V G WR DVAIK I F + S + F E ILS Sbjct: 1287 NELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSS-----LVMFQNEVGILSK 1341 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPNVV F G G + VTE+ Sbjct: 1342 LRHPNVVQFLGACTAGGEDHHCIVTEW 1368
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 51.2 bits (121), Expect = 2e-06 Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 1/103 (0%) Frame = +1 Query: 265 AEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSER 441 A+ +K + I + L+ IK LG+G +G V+ G W G VA+K +K Sbjct: 253 ADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPE---- 308 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTE+ Sbjct: 309 -----SFLEEAQIMKKLRHDKLVQLYAVVSEEP---IYIVTEY 343
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 50.4 bits (119), Expect = 3e-06 Identities = 34/100 (34%), Positives = 49/100 (49%) Frame = +1 Query: 223 SCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKR 402 S SS S EA + + I ++E + +G G +G V KWR DVAIK+ Sbjct: 5 SAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQ 64 Query: 403 IKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYG 522 I++ SER+ I E + LS ++HPN+V YG Sbjct: 65 IESE------SERKAFIV----ELRQLSRVNHPNIVKLYG 94
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 50.1 bits (118), Expect = 4e-06 Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 1/97 (1%) Frame = +1 Query: 283 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIAD 459 +K + I + L+ IK LG+G +G V+ G W G VAIK +K Sbjct: 259 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---------S 309 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTE+ Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEY 343
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 50.1 bits (118), Expect = 4e-06 Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 1/97 (1%) Frame = +1 Query: 283 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIAD 459 +K + I + L+ IK LG+G +G V+ G W G VAIK +K Sbjct: 259 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---------S 309 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTE+ Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEY 343
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 50.1 bits (118), Expect = 4e-06 Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Frame = +1 Query: 283 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPSERERLIAD 459 +K + I D + I++LG+G +G V+ G W VA+K +KA A Sbjct: 84 TKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQP---------AA 134 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDG 537 F EAQI+ L HP ++ Y V G Sbjct: 135 FLAEAQIMKKLRHPKLIQLYAVCTQG 160
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 50.1 bits (118), Expect = 4e-06 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 1/121 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + S+ + DL+ ++ +G G +G V G +RG Sbjct: 159 DADGLCSRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSG-LYIVTE 267 Query: 568 F 570 + Sbjct: 268 Y 268
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 50.1 bits (118), Expect = 4e-06 Identities = 30/86 (34%), Positives = 47/86 (54%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++E + +GSG++G V+ G+ R VAIKR +A+ + + + F +E IL L Sbjct: 460 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQL 514 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 +HP VV F G D P A VT++ Sbjct: 515 NHPCVVQFVGACLDDP-SQFAIVTQY 539
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 50.1 bits (118), Expect = 4e-06 Identities = 30/86 (34%), Positives = 47/86 (54%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++E + +GSG++G V+ G+ R VAIKR +A+ + + + F +E IL L Sbjct: 461 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQL 515 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 +HP VV F G D P A VT++ Sbjct: 516 NHPCVVQFVGACLDDP-SQFAIVTQY 540
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 49.7 bits (117), Expect = 6e-06 Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 1/103 (0%) Frame = +1 Query: 265 AEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSER 441 A+ +K + I + L+ +++LG+G +G V+ G W G VA+K +K Sbjct: 252 ADLSVKTKDVWEIPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPEA--- 308 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 309 ------FLEEAQIMKRLRHDKLVQLYAVVSEEP---IYIVTEF 342
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 49.7 bits (117), Expect = 6e-06 Identities = 26/76 (34%), Positives = 39/76 (51%), Gaps = 1/76 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I + ++ +K LGSG +G V+ G W VA+K +K D DF +EAQ Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN---------DFLREAQ 279 Query: 478 ILSSLHHPNVVSFYGV 525 I+ +L HP ++ Y V Sbjct: 280 IMKNLRHPKLIQLYAV 295
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 49.3 bits (116), Expect = 8e-06 Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 1/71 (1%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 ++LG G +G V+ G W G VA+K +K + + DF +EAQ++ +HHPN Sbjct: 70 RKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTME---------VKDFVQEAQVMKKIHHPN 120 Query: 505 VVSFYGVVRDG 537 ++ Y V G Sbjct: 121 LLQLYAVCTIG 131
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 49.3 bits (116), Expect = 8e-06 Identities = 35/94 (37%), Positives = 48/94 (51%), Gaps = 1/94 (1%) Frame = +1 Query: 247 GIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFD 423 G + P A L G I +L ++E+GSG +G V G W D VAIK I+ + Sbjct: 341 GRQKAPVTA-GLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIR----E 395 Query: 424 GRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 G SE DF +EA+++ L HP +V YGV Sbjct: 396 GAMSEE-----DFIEEAEVMMKLSHPKLVQLYGV 424
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 48.9 bits (115), Expect = 1e-05 Identities = 34/94 (36%), Positives = 50/94 (53%) Frame = +1 Query: 241 SSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCF 420 SS E A ++ L+ K ++EE+ +G G +G V KWR DVAIK+I++ Sbjct: 13 SSAGEMIEAPSQVLNFEEIDYKEIEVEEV--VGRGAFGVVCKAKWRAKDVAIKQIESE-- 68 Query: 421 DGRPSERERLIADFWKEAQILSSLHHPNVVSFYG 522 SER+ I E + LS ++HPN+V YG Sbjct: 69 ----SERKAFIV----ELRQLSRVNHPNIVKLYG 94
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 48.5 bits (114), Expect = 1e-05 Identities = 33/102 (32%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + LSK I D L +LG G +G V+ G W G VAIK +K Sbjct: 249 QTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 304 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 305 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 338
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/83 (38%), Positives = 45/83 (54%), Gaps = 1/83 (1%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 456 L G I+ +L ++E+GSG +G V G W D VAIK I+ +G SE Sbjct: 356 LRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQ----EGAMSEE----- 406 Query: 457 DFWKEAQILSSLHHPNVVSFYGV 525 DF +EA+++ L HP +V YGV Sbjct: 407 DFIEEAEVMMKLSHPKLVQLYGV 429
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKVKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610
>ACK1_HUMAN (Q07912) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine| kinase non-receptor protein 2) Length = 1036 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/111 (27%), Positives = 44/111 (39%) Frame = +1 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 P H K+S PA L I DL +++LG G++G V G+W Sbjct: 90 PPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPS 149 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 + C + + DF +E + SL H N++ YGVV P Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP 200
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 13/95 (13%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P+ + L+A Sbjct: 532 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTNDKMLVAVKALK 577 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV DG Sbjct: 578 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 612
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/114 (30%), Positives = 56/114 (49%), Gaps = 3/114 (2%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKE---LGSGTYGSVFHGKWRGCDVAIKRIK 408 K + A+ L GL + + L EI+ +GSG++G V+ G+ R VAIKR + Sbjct: 535 KIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYR 594 Query: 409 ASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 A+ + + + F +E IL L+HP V+ F G + P A VT++ Sbjct: 595 ANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQY 642
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/114 (30%), Positives = 56/114 (49%), Gaps = 3/114 (2%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKE---LGSGTYGSVFHGKWRGCDVAIKRIK 408 K + A+ L GL + + L EI+ +GSG++G V+ G+ R VAIKR + Sbjct: 433 KIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYR 492 Query: 409 ASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 A+ + + + F +E IL L+HP V+ F G + P A VT++ Sbjct: 493 ANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQY 540
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 47.8 bits (112), Expect = 2e-05 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 1/91 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +++E + E+G G +GSV KW R +VA K +++S +ERE+ + EA+ Sbjct: 215 INRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSS-----KAEREKFVL----EAK 265 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 I+ L H +V GV + D + + E+ Sbjct: 266 IMHKLRHRKIVELLGVCTEPQDMPMLIIVEY 296
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 47.8 bits (112), Expect = 2e-05 Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 6/124 (4%) Frame = +1 Query: 217 HGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR--GCDV 390 +G + + SG++ +P + + L N D E+I+E+G G +G VF K R G Sbjct: 209 NGLGENKRKSGVKVSPDDVQRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRY 268 Query: 391 AIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFY----GVVRDGPDGSLAT 558 AIKR+K ++ +E E Q L+ L+H N+V ++ GV D P+ S++ Sbjct: 269 AIKRVK---YNTEKAEH---------EVQALAELNHVNIVQYHSCWEGVDYD-PEHSMSD 315 Query: 559 VTEF 570 + + Sbjct: 316 TSRY 319
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 47.8 bits (112), Expect = 2e-05 Identities = 36/92 (39%), Positives = 49/92 (53%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L +KE+GSG +G V G+WR VAIK I +G SE DF +EA+ Sbjct: 266 IDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAIN----EGSMSEE-----DFIEEAK 316 Query: 478 ILSSLHHPNVVSFYGV-VRDGPDGSLATVTEF 570 ++ L H +V YGV ++ P L VTEF Sbjct: 317 VMMKLSHSRLVQLYGVCIQQKP---LYIVTEF 345
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 47.8 bits (112), Expect = 2e-05 Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L IKE+GSG +G V G+WR VAIK I +G SE DF +EA+ Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN----EGSMSEE-----DFIEEAK 316 Query: 478 ILSSLHHPNVVSFYGV-VRDGPDGSLATVTEF 570 ++ L H +V YGV ++ P L VTEF Sbjct: 317 VMMKLSHSKLVQLYGVCIQRKP---LYIVTEF 345
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 1/91 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L ++ELGSG +G V GKWR VAIK I+ +G E DF +EA+ Sbjct: 364 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR----EGAMCEE-----DFIEEAK 414 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ L HP +V YGV + VTEF Sbjct: 415 VMMKLTHPKLVQLYGVCTQ--QKPIYIVTEF 443
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 1/91 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L ++ELGSG +G V GKWR VAIK I+ +G E DF +EA+ Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR----EGAMCEE-----DFIEEAK 415 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ L HP +V YGV + VTEF Sbjct: 416 VMMKLTHPKLVQLYGVCTQ--QKPIYIVTEF 444
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 47.8 bits (112), Expect = 2e-05 Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 7/84 (8%) Frame = +1 Query: 295 QTIKNDDLEEIKELGSGTYGSVFHG-------KWRGCDVAIKRIKASCFDGRPSERERLI 453 +T++ + ++ +G G +G VF G K VA+K +K SC D L Sbjct: 497 KTVRLQTILLMRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDS-------LK 549 Query: 454 ADFWKEAQILSSLHHPNVVSFYGV 525 DF +EA++L+++ H N+V+FYGV Sbjct: 550 RDFEREAEMLATIEHANIVTFYGV 573
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K +K++DL +++G G +G VF G+ R + VA+K SC + P + L Sbjct: 546 AVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVK----SCRETLPPD---L 598 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL +HPN+V GV Sbjct: 599 KAKFLQEARILKQYNHPNIVRLIGV 623
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 47.4 bits (111), Expect = 3e-05 Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + LS+ I D L +LG G +G V+ G W G VAIK +K Sbjct: 249 QTQGLSRDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 304 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 305 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 338
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 47.4 bits (111), Expect = 3e-05 Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 14/135 (10%) Frame = +1 Query: 160 DKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKN---------- 309 D G+ D G P S + S + S E ++L+ + +KN Sbjct: 242 DAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYYW 301 Query: 310 ----DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 +++ +K +G+G++G+VF G+W G DVA+K +K + +P+ + F E Q Sbjct: 302 EVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QPTAEQ--AQAFKNEMQ 354 Query: 478 ILSSLHHPNVVSFYG 522 +L H N++ F G Sbjct: 355 VLRKTRHVNILLFMG 369
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 47.4 bits (111), Expect = 3e-05 Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 LHHPN+V V+ D L + EF Sbjct: 56 KELHHPNIVCLQDVLMQ--DARLYLIFEF 82
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 47.0 bits (110), Expect = 4e-05 Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 1/121 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 568 F 570 + Sbjct: 268 Y 268
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 47.0 bits (110), Expect = 4e-05 Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 1/121 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 568 F 570 + Sbjct: 268 Y 268
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 47.0 bits (110), Expect = 4e-05 Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 1/121 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 568 F 570 + Sbjct: 268 Y 268
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 260 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 311 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 312 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEF 349
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 46.6 bits (109), Expect = 5e-05 Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ R G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+VS V+ D L + EF Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEF 82
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 46.6 bits (109), Expect = 5e-05 Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ R G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+VS V+ D L + EF Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEF 82
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 309 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 310 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEF 347
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 309 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 310 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEF 347
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 251 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM-------- 302 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 303 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEF 340
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 256 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM-------- 307 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 308 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEF 345
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 46.2 bits (108), Expect = 6e-05 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L++I++LG G +G V G G VA+K +K P RE ++ W+E Sbjct: 875 LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLK-------PENREEQSSNLWREIH 927 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 IL L+H N+V + G+ + S+ + EF Sbjct: 928 ILRELYHENIVKYKGIWHEEGGRSIKLIMEF 958
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 46.2 bits (108), Expect = 6e-05 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 1/76 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I L+ +++LGSG +G V+ G W VAIK +K+ D + DF EAQ Sbjct: 243 IDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPK---------DFLAEAQ 293 Query: 478 ILSSLHHPNVVSFYGV 525 I+ L H ++ Y V Sbjct: 294 IMKKLRHTKLIQLYAV 309
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 46.2 bits (108), Expect = 6e-05 Identities = 33/100 (33%), Positives = 48/100 (48%), Gaps = 2/100 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKND--DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 +TP A LS+ L D + + LGSG +GSV+ + G VAIK++ R Sbjct: 39 ATPPRAPRLSRRLAWCFIDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLR 98 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 S+R +FW E I + LHH N++ P+GS Sbjct: 99 ASQR-----NFWAELNI-ARLHHDNIIRVVAASTRTPEGS 132
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 46.2 bits (108), Expect = 6e-05 Identities = 24/70 (34%), Positives = 42/70 (60%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 +++ +K +G+G++G+VF G+W G DVA+K +K S +P+ + F E Q+L Sbjct: 309 EVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVS----QPTAEQ--AQAFKNEMQVLRKT 361 Query: 493 HHPNVVSFYG 522 H N++ F G Sbjct: 362 RHVNILLFMG 371
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 46.2 bits (108), Expect = 6e-05 Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+VS V+ D L + EF Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEF 82
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 46.2 bits (108), Expect = 6e-05 Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+VS V+ D L + EF Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEF 82
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 46.2 bits (108), Expect = 6e-05 Identities = 34/135 (25%), Positives = 62/135 (45%), Gaps = 14/135 (10%) Frame = +1 Query: 160 DKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKN---------- 309 D G+ D G P S + S + + E ++L+ + +KN Sbjct: 242 DAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYW 301 Query: 310 ----DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 +++ +K +G+G++G+VF G+W G DVA+K +K + +P+ + F E Q Sbjct: 302 EVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QPTAEQ--AQAFKNEMQ 354 Query: 478 ILSSLHHPNVVSFYG 522 +L H N++ F G Sbjct: 355 VLRKTRHVNILLFMG 369
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 46.2 bits (108), Expect = 6e-05 Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 1/76 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR-GCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +++ +++LG G +G VF+GKWR DVA+K ++ E A F +EA Sbjct: 279 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR---------EGTMSTAAFLQEAA 329 Query: 478 ILSSLHHPNVVSFYGV 525 I+ H +V+ Y V Sbjct: 330 IMKKFRHNRLVALYAV 345
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 339
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 339
>PR2_DROME (Q9I7F7) Tyrosine-protein kinase PR2 (EC 2.7.10.2)| Length = 1337 Score = 45.8 bits (107), Expect = 8e-05 Identities = 35/93 (37%), Positives = 47/93 (50%), Gaps = 4/93 (4%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIK-RIKASCFDGRPSERERLIA---DFWK 468 I D + K+LG+G +G V G W + I+ IK C RER+ + +F K Sbjct: 128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLC-------RERMQSNPMEFLK 180 Query: 469 EAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 EA I+ S+ H N+V YGVV SL VTE Sbjct: 181 EAAIMHSIEHENIVRLYGVVL--ATDSLMLVTE 211
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 186 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 236 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ + HPN+V GV P +TEF Sbjct: 237 AVMKEIKHPNLVQLLGVCTREP--PFYIITEF 266
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 45.8 bits (107), Expect = 8e-05 Identities = 33/106 (31%), Positives = 48/106 (45%), Gaps = 1/106 (0%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRP 432 S + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 SVKPQTQGLAKDAWEIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTM---- 305 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + F +EAQI+ L H +V Y VV + P + VTE+ Sbjct: 306 -----MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEY 343
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 339
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 339
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 287 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ + HPN+V GV P +TEF Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEF 317
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 45.8 bits (107), Expect = 8e-05 Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 6/91 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L++I++LG G +G V G G VA+K +K P RE + W+E Sbjct: 872 LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLK-------PENREEQSNNLWREIH 924 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 IL L+H N+V + G+ + S+ + EF Sbjct: 925 ILRELYHENIVKYKGICNEEGGRSIKLIMEF 955
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 45.8 bits (107), Expect = 8e-05 Identities = 33/106 (31%), Positives = 46/106 (43%), Gaps = 1/106 (0%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRP 432 S + L+K + D L K+LG G + V+ G W G VAIK +K Sbjct: 247 SCTPQTSGLAKDAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPE- 305 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTE+ Sbjct: 306 --------SFLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEY 340
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 45.8 bits (107), Expect = 8e-05 Identities = 39/150 (26%), Positives = 66/150 (44%), Gaps = 14/150 (9%) Frame = +1 Query: 115 VQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGL 294 VQ A+ N+ N G D G P S + S S E ++L+ Sbjct: 232 VQLTAQSFNTDAAGNRGGG---DGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDK 288 Query: 295 QTIKN--------------DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRP 432 + +KN +++ +K +G+G++G+VF G+W G DVA+K +K + +P Sbjct: 289 KKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QP 343 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYG 522 + + F E Q+L H N++ F G Sbjct: 344 TAEQ--AQAFKNEMQVLRKTRHVNILLFMG 371
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 45.8 bits (107), Expect = 8e-05 Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + ++K I + L LG G +G V+ G W G VAIK +K Sbjct: 261 QTQGIAKDAWEIPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEA---- 316 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 317 -----FLEEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEF 350
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 123 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 173 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ + HPN+V GV P +TEF Sbjct: 174 AVMKEIKHPNLVQLLGVCTREP--PFYIITEF 203
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 339
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 45.8 bits (107), Expect = 8e-05 Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSER 441 E E +G +D +++++G GTYG V+ GK R + VA+K+I+ SE Sbjct: 6 EGEVAHEGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLE------SED 59 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVV 528 E + + +E +L L HPNVV V+ Sbjct: 60 EGVPSTAVREISLLKELQHPNVVGLEAVI 88
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 287 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ + HPN+V GV P +TEF Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEF 317
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 253 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 308 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 309 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 342
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 253 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 308 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 309 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 342
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 45.8 bits (107), Expect = 8e-05 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 313 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 314 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEY 347
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/77 (35%), Positives = 42/77 (54%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 +++ E++ LGSG G+VF GK+R +VAIK++ RE+ D + L Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDI----KHLRK 210 Query: 490 LHHPNVVSFYGVVRDGP 540 L HPN+++F GV P Sbjct: 211 LKHPNIIAFKGVCTQAP 227
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/77 (35%), Positives = 42/77 (54%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 +++ E++ LGSG G+VF GK+R +VAIK++ RE+ D + L Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDI----KHLRK 210 Query: 490 LHHPNVVSFYGVVRDGP 540 L HPN+++F GV P Sbjct: 211 LKHPNIIAFKGVCTQAP 227
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 1/92 (1%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 F +EAQ++ L H +V Y VV + P Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP 332
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Frame = +1 Query: 331 ELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 +LG G YG V+ G W+ C +A+K +K D P + +F EA I+ LHH N Sbjct: 316 KLGGGQYGDVYEGYWKRHDCTIAVKALKE---DAMP------LHEFLAEAAIMKDLHHKN 366 Query: 505 VVSFYGVVRDGPDGSLATVTEF 570 +V GV + +TEF Sbjct: 367 LVRLLGVCTH--EAPFYIITEF 386
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 1/102 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTE+ Sbjct: 306 -----FLQEAQVMKKLRHEKLVRLYAVVSEEP---IYIVTEY 339
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/90 (31%), Positives = 45/90 (50%), Gaps = 2/90 (2%) Frame = +1 Query: 307 NDDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 + +++++LG+GTY +V+ G K G VA+K +K +G PS R E + Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-------EISL 56 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 + L H N+V Y V+ + L V EF Sbjct: 57 MKELKHENIVRLYDVIH--TENKLTLVFEF 84
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 45.4 bits (106), Expect = 1e-04 Identities = 23/71 (32%), Positives = 39/71 (54%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 +D++ I+++G G + V+ G W+G VAIK++K + E+ F +E Q L Sbjct: 106 NDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLKII------GDEEQFKERFIREVQNLKK 159 Query: 490 LHHPNVVSFYG 522 +H N+V F G Sbjct: 160 GNHQNIVMFIG 170
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 45.4 bits (106), Expect = 1e-04 Identities = 46/156 (29%), Positives = 63/156 (40%), Gaps = 4/156 (2%) Frame = +1 Query: 106 PVEVQP--DARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 P+E+ P D RP +SPV KDGK F T S P Sbjct: 12 PLELSPSADLRPCSSPVVIPGKDGKAFLGGTP---------------SPRTRRLPPRLAW 56 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 S I D L ++ LGSG +G+V+ + G VA+K++K S + S + Sbjct: 57 CS-----IDWDRLCLLQPLGSGGFGAVYKATYHGVTVAVKQVKKSSKNRLASRQ-----S 106 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGP--DGSLATV 561 FW E + + L H NVV P SL T+ Sbjct: 107 FWAELNV-ARLQHDNVVRVVAASTCAPASQNSLGTI 141
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.1 bits (105), Expect = 1e-04 Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 1/92 (1%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 F +EAQ++ L H +V Y VV + P Sbjct: 306 -----FLQEAQVMKKLRHKKLVQLYAVVSEEP 332
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 45.1 bits (105), Expect = 1e-04 Identities = 29/78 (37%), Positives = 43/78 (55%), Gaps = 7/78 (8%) Frame = +1 Query: 322 EIKELGSGTYGSVFHGKWRG--CDVAIKRIKASCFD-GRPSERERLIADF----WKEAQI 480 ++++LGSG YG V K + + AIK IK S FD GR ++ + I F + E + Sbjct: 58 KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFHEEIYNEISL 117 Query: 481 LSSLHHPNVVSFYGVVRD 534 L SL HPN++ + V D Sbjct: 118 LKSLDHPNIIKLFDVFED 135
>ACK2_BOVIN (O02742) Activated CDC42 kinase 2 (EC 2.7.10.2) (ACK-2)| Length = 747 Score = 45.1 bits (105), Expect = 1e-04 Identities = 29/111 (26%), Positives = 43/111 (38%) Frame = +1 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 P H K+S A +L I DL ++LG G++G V G+W Sbjct: 90 PPHHSQSTFRKTSPTPGGSAGEGSLQSLTCLIGEKDLHLFEKLGDGSFGVVRRGEWDAPS 149 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 + C + + DF +E + SL H N++ YGVV P Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP 200
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 583 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV +G Sbjct: 584 --DFHREAELLTNLQHEHIVKFYGVCVEG 610
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + L Sbjct: 548 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---L 600 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL HPN+V GV Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGV 625
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 529 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 582 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV +G Sbjct: 583 --DFHREAELLTNLQHEHIVKFYGVCVEG 609
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 529 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 582 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV +G Sbjct: 583 --DFHREAELLTNLQHEHIVKFYGVCVEG 609
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 44.7 bits (104), Expect = 2e-04 Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 2/98 (2%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKA 411 + SGI T A+ K + ++D+ + +G G +G VF G+ R + VA+K Sbjct: 250 RKSGIVLT----RAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVK---- 301 Query: 412 SCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 SC + P E L A F +EA+IL +HPN+V GV Sbjct: 302 SCRETLPPE---LKAKFLQEARILKQYNHPNIVRLIGV 336
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/89 (33%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G K G V +K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVTMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+VS V+ D L + EF Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEF 82
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 44.7 bits (104), Expect = 2e-04 Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 2/98 (2%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKA 411 + SGI T A+ K + ++D+ + +G G +G VF G+ R + VA+K Sbjct: 590 RKSGIVLT----RAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVK---- 641 Query: 412 SCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 SC + P E L A F +EA+IL +HPN+V GV Sbjct: 642 SCRETLPPE---LKAKFLQEARILKQCNHPNIVRLIGV 676
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 44.7 bits (104), Expect = 2e-04 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 2/86 (2%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++++ LG+GTY +V+ G K G VA+K +K +G PS R E ++ L Sbjct: 10 KQLERLGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIR-------EISLMKEL 62 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 H N+V Y V+ + L V EF Sbjct: 63 KHENIVRLYDVIH--TENKLTLVFEF 86
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 1/98 (1%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 456 L+K I + + LG+G +G V+ G W G VA+K +K + Sbjct: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKA-------- 302 Query: 457 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQ++ L H +V Y VV + P + VTEF Sbjct: 303 -FLEEAQVMKLLRHDKLVQLYAVVSEEP---IYIVTEF 336
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 526 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 579 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDG 537 DF +EA++L++L H ++V FYGV +G Sbjct: 580 --DFHREAELLTNLQHEHIVKFYGVCVEG 606
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 2/78 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ + +++G GTYG V+ + G DVA+K+I+ E E + + +E +L Sbjct: 6 DNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLE------GETEGVPSTAIREISLL 59 Query: 484 SSLHHPNVVSFYGVVRDG 537 +L HPNVV + VV G Sbjct: 60 KNLKHPNVVQLFDVVISG 77
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 DD +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 DDYLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLE------SEEEGVPSTAVREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPNVV V+ + L V EF Sbjct: 56 KELQHPNVVRLLDVLMQ--ESKLYLVFEF 82
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 44.3 bits (103), Expect = 2e-04 Identities = 23/76 (30%), Positives = 38/76 (50%), Gaps = 1/76 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I+ ++ ++ LG+G +G V+ G W G VA+K +K I +F +EA Sbjct: 235 IEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------IEEFLEEAS 285 Query: 478 ILSSLHHPNVVSFYGV 525 I+ L HP ++ Y V Sbjct: 286 IMKQLRHPKLIQLYAV 301
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 44.3 bits (103), Expect = 2e-04 Identities = 28/83 (33%), Positives = 44/83 (53%), Gaps = 3/83 (3%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGS---VFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKE 471 +KN+DL+ + ELG+G G+ V H K + K D +PS R++++ +E Sbjct: 104 LKNEDLKTLSELGAGNGGTVTKVLHEK----SGTVMAKKVVFIDAKPSVRKQIL----RE 155 Query: 472 AQILSSLHHPNVVSFYGVVRDGP 540 QIL + P +VSFYG + P Sbjct: 156 LQILHECNSPYIVSFYGAYLNEP 178
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 44.3 bits (103), Expect = 2e-04 Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 2/82 (2%) Frame = +1 Query: 331 ELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 +LG G YG V+ W+ G VA+K +K E + DF +EA I+ + HPN Sbjct: 376 KLGGGQYGEVYEAVWKRYGNTVAVKTLK---------EDTMALKDFLEEAAIMKEMKHPN 426 Query: 505 VVSFYGVVRDGPDGSLATVTEF 570 +V GV P +TEF Sbjct: 427 LVQLIGVCTREP--PFYIITEF 446
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 44.3 bits (103), Expect = 2e-04 Identities = 31/98 (31%), Positives = 45/98 (45%), Gaps = 1/98 (1%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 456 L+K I + + LG+G +G V+ G W G VA+K +K + S Sbjct: 274 LAKDAWEISRSSITLQRRLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKAS------- 326 Query: 457 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 +EAQI+ L H +V Y VV P+ + VTEF Sbjct: 327 --LEEAQIMKLLRHDKLVQLYAVV---PEEPIYIVTEF 359
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 44.3 bits (103), Expect = 2e-04 Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 2/92 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 + + +++++LG+GTY +V+ G K G VA+K +K +G PS R E Sbjct: 1 MSSSQFKQLEKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIR-------EI 53 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ L H N+V Y V+ + L V E+ Sbjct: 54 SLMKELKHDNIVRLYDVIH--TENKLTLVFEY 83
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 44.3 bits (103), Expect = 2e-04 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 2/93 (2%) Frame = +1 Query: 298 TIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKE 471 T + +++++LG GTY +V+ G+ R G VA+K I +G PS R E Sbjct: 2 TGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIR-------E 54 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ L H N+V+ Y V+ + L V EF Sbjct: 55 ISLMKELDHENIVTLYDVIH--TENKLTLVFEF 85
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 44.3 bits (103), Expect = 2e-04 Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 1/76 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I+ ++ ++ LG+G +G V+ G W G VA+K +K + +F +EA Sbjct: 235 IEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------VEEFLQEAS 285 Query: 478 ILSSLHHPNVVSFYGV 525 I+ L HP ++ Y V Sbjct: 286 IMKRLRHPKLIQLYAV 301
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 44.3 bits (103), Expect = 2e-04 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 2/93 (2%) Frame = +1 Query: 298 TIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKE 471 T + +++++LG GTY +V+ G+ R G VA+K I +G PS R E Sbjct: 2 TGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIR-------E 54 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++ L H N+V+ Y V+ + L V E+ Sbjct: 55 ISLMKELDHENIVTLYDVIH--TENKLTLVFEY 85
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 43.9 bits (102), Expect = 3e-04 Identities = 25/77 (32%), Positives = 41/77 (53%), Gaps = 2/77 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGC--DVAIKRIKASCFDGRPSERERLIADFWKEA 474 + NDD+ ++ +G G +G V+ K + DVA+K +C P E++R F +E Sbjct: 1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVK----TCRMTLPDEQKR---KFLQEG 1110 Query: 475 QILSSLHHPNVVSFYGV 525 +IL HPN+V G+ Sbjct: 1111 RILKQYDHPNIVKLIGI 1127
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 43.9 bits (102), Expect = 3e-04 Identities = 29/89 (32%), Positives = 47/89 (52%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII----RELQV 117 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 L + P +V FYGV DG ++ E Sbjct: 118 LHECNSPYIVGFYGVFYS--DGEISICME 144
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 43.9 bits (102), Expect = 3e-04 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + + Sbjct: 203 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---I 255 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL HPN+V GV Sbjct: 256 KAKFLQEAKILKQYSHPNIVRLIGV 280
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 43.9 bits (102), Expect = 3e-04 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + + Sbjct: 546 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---I 598 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL HPN+V GV Sbjct: 599 KAKFLQEAKILKQYSHPNIVRLIGV 623
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 43.9 bits (102), Expect = 3e-04 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + + Sbjct: 335 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---I 387 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL HPN+V GV Sbjct: 388 KAKFLQEAKILKQYSHPNIVRLIGV 412
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 43.9 bits (102), Expect = 3e-04 Identities = 28/85 (32%), Positives = 44/85 (51%), Gaps = 2/85 (2%) Frame = +1 Query: 322 EIKEL-GSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSLH 495 E+KEL G+G +G V+ W+G +VA+K + P + A+ +EA++ + L Sbjct: 125 ELKELIGAGGFGQVYRATWQGQEVAVKAARQD-----PEQDAAAAAESVRREARLFAMLR 179 Query: 496 HPNVVSFYGVVRDGPDGSLATVTEF 570 HPN++ GV P L V EF Sbjct: 180 HPNIIELRGVCLQQP--HLCLVLEF 202
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 43.9 bits (102), Expect = 3e-04 Identities = 35/108 (32%), Positives = 49/108 (45%), Gaps = 15/108 (13%) Frame = +1 Query: 262 PAEAEALSKGLQTIKNDDLEEI---------KELGSGTYGSVFHGKW-----RGCDVAIK 399 P KG QT+KN+ + I KELG G +GSV G W + +VA+K Sbjct: 457 PNSVNVGQKGDQTMKNNAQQNIILKESISFGKELGVGEFGSVIKGIWLSPGGKEINVAMK 516 Query: 400 RI-KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 + K G +F +EA ++S L+HP +VS GV P Sbjct: 517 TLHKDKMVQGE--------KEFLREALVMSQLNHPCIVSLLGVCLGPP 556
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 43.9 bits (102), Expect = 3e-04 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 1/106 (0%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR-GCDVAIKRIKASCFDGRP 432 +T + L+K I + + + LG+G +G V+ G W VA+K +K + Sbjct: 231 TTKPQTLGLAKDAWEIDRNSIALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKA 290 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EAQI+ L H +V Y VV + P + VTEF Sbjct: 291 ---------FLEEAQIMKLLRHDKLVQLYAVVSEEP---IYIVTEF 324
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 43.5 bits (101), Expect = 4e-04 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDL 130 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 R S+R FW E I + L H N+V P+ S Sbjct: 131 RASQR-----SFWAELNI-AGLRHDNIVRVVAASTRTPEDS 165
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 43.5 bits (101), Expect = 4e-04 Identities = 27/79 (34%), Positives = 44/79 (55%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K + D P + + F E +L H N++ Sbjct: 346 IGSGSFGTVYKGKWHG-DVAVKILKVT--DPTPEQ----LQAFRNEVAVLRKTRHVNILL 398 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 399 FMGYM---TKDNLAIVTQW 414
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 43.5 bits (101), Expect = 4e-04 Identities = 41/169 (24%), Positives = 77/169 (45%), Gaps = 4/169 (2%) Frame = +1 Query: 28 ISENRLNFLPEFVASVK--KAALEESEKPVEVQPDARPANSPVCDNDKDGKKFDENTDGD 201 +SE+ ++P V ++ +AA + S K P P++S V +++ + T + Sbjct: 121 VSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPF--PSSSGVSNSNNNRTS---TTATE 175 Query: 202 QDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG 381 + P + + H S+ + + E L+ D LG G +G V+ GKW+ Sbjct: 176 EIPSLESLGNIHISTVQRAAESLLEIDYAELENA-TDGWSPDNRLGQGGFGDVYRGKWKQ 234 Query: 382 CDVAIK--RIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYG 522 DVAIK ++ D + E + + E + L+S+ H N+++ YG Sbjct: 235 LDVAIKVMNYRSPNIDQKMVE----LQQSYNELKYLNSIRHDNILALYG 279
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 43.5 bits (101), Expect = 4e-04 Identities = 35/118 (29%), Positives = 49/118 (41%), Gaps = 1/118 (0%) Frame = +1 Query: 220 GSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAI 396 G C +TP + L+K + D L ++LG G + V+ G W G VAI Sbjct: 236 GLCFNLTVIATNNTP-QTVGLAKDAWEVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAI 294 Query: 397 KRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 K +K F +EAQI+ L H +V Y VV P + VTE+ Sbjct: 295 KTLKPGTMSPE---------SFLEEAQIMKKLKHDKLVQLYAVVSRRP---IYIVTEY 340
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 43.5 bits (101), Expect = 4e-04 Identities = 23/77 (29%), Positives = 38/77 (49%), Gaps = 2/77 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 333 Query: 475 QILSSLHHPNVVSFYGV 525 ++ + HPN+V GV Sbjct: 334 AVMKEIKHPNLVQLLGV 350
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 43.5 bits (101), Expect = 4e-04 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 52 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDL 110 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 R S+R FW E I + L H N+V P+ S Sbjct: 111 RASQR-----SFWAELNI-AGLRHDNIVRVVAASTRTPEDS 145
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 6/91 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ I++LG G +G V G G VA+K +K P IAD KE + Sbjct: 874 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-------PESGGNHIADLKKEIE 926 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 IL +L+H N+V + G+ + + + EF Sbjct: 927 ILRNLYHENIVKYKGICMEDGGNGIKLIMEF 957
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 43.5 bits (101), Expect = 4e-04 Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 1/92 (1%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 247 QTQGLAKDAWEIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 302 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 F +EAQ++ L H +V Y +V + P Sbjct: 303 -----FLQEAQVMKKLRHEKLVQLYAMVSEEP 329
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 43.5 bits (101), Expect = 4e-04 Identities = 26/89 (29%), Positives = 45/89 (50%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSE 438 TP+ L+ +K +L+ +K LGSG +G+V+ G W +K I + + Sbjct: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETT 757 Query: 439 RERLIADFWKEAQILSSLHHPNVVSFYGV 525 + +F EA I++S+ HP++V GV Sbjct: 758 GPKANVEFMDEALIMASMDHPHLVRLLGV 786
>FAK1_XENLA (Q91738) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1068 Score = 43.1 bits (100), Expect = 5e-04 Identities = 44/182 (24%), Positives = 79/182 (43%), Gaps = 11/182 (6%) Frame = +1 Query: 28 ISENRLNFLPEFVASVKKAALEESEKPVEVQPDARPANSPVCDNDKDGKK-----FDENT 192 I+EN + + + V A+ +P + A P+ + +N+K G + + Sbjct: 336 IAENMADLIDGYCRLVSGASESFIIRPQKEGERALPSIPKLANNEKHGVRPHAVSVSDEF 395 Query: 193 DGDQDPDVHGSCDQHKSSGIESTPAEAEALSK-GLQTIKNDDLEEIKELGSGTYGSVFHG 369 GD+ D D+ + + P+++ L + G I+ D +E + +G G +G V G Sbjct: 396 SGDETDDYAEIIDEEDTY---TMPSKSYGLDEAGDYEIQRDRIELGRCIGEGQFGDVHQG 452 Query: 370 KWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRD 534 + + VAIK K D S RE+ F +EA + HP++V GV+ + Sbjct: 453 VYMSPENPAMAVAIKTCKNCTSD---SVREK----FLQEALTMRQFDHPHIVKLIGVITE 505 Query: 535 GP 540 P Sbjct: 506 NP 507
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 43.1 bits (100), Expect = 5e-04 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 88 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 146 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 R S+R FW E I + L H N+V P+ S Sbjct: 147 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDS 181
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 43.1 bits (100), Expect = 5e-04 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 41 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 99 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 R S+R FW E I + L H N+V P+ S Sbjct: 100 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDS 134
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 43.1 bits (100), Expect = 5e-04 Identities = 38/156 (24%), Positives = 69/156 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 +E Q+L + P +V FYG DG ++ E Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICME 143
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 43.1 bits (100), Expect = 5e-04 Identities = 38/156 (24%), Positives = 69/156 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 +E Q+L + P +V FYG DG ++ E Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICME 143
>MP2K1_PANTR (Q9XT09) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 43.1 bits (100), Expect = 5e-04 Identities = 38/156 (24%), Positives = 69/156 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 +E Q+L + P +V FYG DG ++ E Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICME 143
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 43.1 bits (100), Expect = 5e-04 Identities = 38/156 (24%), Positives = 69/156 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 +E Q+L + P +V FYG DG ++ E Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICME 143
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 43.1 bits (100), Expect = 5e-04 Identities = 38/156 (24%), Positives = 69/156 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 +E Q+L + P +V FYG DG ++ E Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICME 143
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 43.1 bits (100), Expect = 5e-04 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 130 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 R S+R FW E I + L H N+V P+ S Sbjct: 131 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDS 165
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 43.1 bits (100), Expect = 5e-04 Identities = 26/89 (29%), Positives = 45/89 (50%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSE 438 TP+ L+ +K +L+ +K LGSG +G+V+ G W +K I + + Sbjct: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETT 757 Query: 439 RERLIADFWKEAQILSSLHHPNVVSFYGV 525 + +F EA I++S+ HP++V GV Sbjct: 758 GPKANVEFMDEALIMASVDHPHLVRLLGV 786
>TOPK_HUMAN (Q96KB5) T-lymphokine-activated killer cell-originated protein| kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3) Length = 322 Score = 43.1 bits (100), Expect = 5e-04 Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 10/92 (10%) Frame = +1 Query: 325 IKELGSGTYGSVF----------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 +++LG GT +V+ H W A+K+I C D S ++ + D EA Sbjct: 35 MQKLGFGTGVNVYLMKRSPRGLSHSPW-----AVKKINPICNDHYRSVYQKRLMD---EA 86 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 +IL SLHHPN+V Y + DGSL E+ Sbjct: 87 KILKSLHHPNIVG-YRAFTEANDGSLCLAMEY 117
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 43.1 bits (100), Expect = 5e-04 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 130 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 R S+R FW E I + L H N+V P+ S Sbjct: 131 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDS 165
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 43.1 bits (100), Expect = 5e-04 Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ +I+++G GTYG V+ G+ + G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+V V+ D L + EF Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEF 82
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 43.1 bits (100), Expect = 5e-04 Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ +I+++G GTYG V+ G+ + G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+V V+ D L + EF Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEF 82
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/79 (34%), Positives = 43/79 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 408 FMGYM---TKDNLAIVTQW 423
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/79 (34%), Positives = 43/79 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 408 FMGYM---TKDNLAIVTQW 423
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 1/92 (1%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 F +EAQ++ L H +V Y VV + P Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP 332
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/79 (34%), Positives = 43/79 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 30 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 82 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 83 FMGYM---TKDNLAIVTQW 98
>ACK1_MOUSE (O54967) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1)| (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Length = 1055 Score = 42.7 bits (99), Expect = 7e-04 Identities = 22/76 (28%), Positives = 35/76 (46%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 I DL +++LG G++G V G+W + C + + DF +E Sbjct: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180 Query: 481 LSSLHHPNVVSFYGVV 528 + SL H N++ YGVV Sbjct: 181 MHSLDHRNLIRLYGVV 196
>E2AK1_SCHPO (O13889) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor 1) Length = 704 Score = 42.7 bits (99), Expect = 7e-04 Identities = 24/71 (33%), Positives = 41/71 (57%), Gaps = 2/71 (2%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 486 D EE++ LG G YGSV+ K+ G + A+K+I S ++ ++E++ L+ Sbjct: 223 DFEELELLGKGGYGSVYKARNKFDGVEYALKKIPLRLRSFSTS------SNIFRESRTLA 276 Query: 487 SLHHPNVVSFY 519 L+HPNV+ F+ Sbjct: 277 RLNHPNVIRFF 287
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/75 (34%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVV 528 L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/75 (34%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVV 528 L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/75 (34%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVV 528 L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/75 (34%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVV 528 L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 5/90 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 L+ I++LG G +G V ++ G VA+K +K P IAD KE +I Sbjct: 864 LKRIRDLGEGHFGKVELCRYDPEDNTGEQVAVKSLK-------PESGGNHIADLKKEIEI 916 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L +L+H N+V + G+ + + + EF Sbjct: 917 LRNLYHENIVKYKGICTEDGGNGIKLIMEF 946
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ +I+++G GTYG V+ G K G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L HPN+V V+ D L + EF Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEF 82
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/86 (30%), Positives = 44/86 (51%), Gaps = 2/86 (2%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++++++G+GTY +V+ G K G VA+K +K +G PS R E ++ L Sbjct: 8 KQLEKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-------EISLMKEL 60 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 H N+V + V+ + L V EF Sbjct: 61 KHDNIVRLFDVIH--TENKLTLVFEF 84
>TOPK_BRARE (Q6DHU8) T-lymphokine-activated killer cell-originated protein| kinase homolog (EC 2.7.12.2) (PDZ-binding kinase) Length = 339 Score = 42.4 bits (98), Expect = 0.001 Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 4/86 (4%) Frame = +1 Query: 325 IKELGSGTYGSVF----HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 +K+LG GT +V+ GK AIK+I + C G+ S ++ + + EA+IL L Sbjct: 39 MKKLGCGTGVNVYLMNRMGKQTHSPWAIKKINSKCAQGQVSVYQKRLCE---EAKILKDL 95 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 HPN+V F DGS EF Sbjct: 96 KHPNIVGFRAFT-TAKDGSKCLAMEF 120
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 42.4 bits (98), Expect = 0.001 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 5/76 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 622 IEEV--IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY-----SEKQR--RDFLSEASI 672 Query: 481 LSSLHHPNVVSFYGVV 528 + HPN++ GVV Sbjct: 673 MGQFDHPNIIRLEGVV 688
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 42.4 bits (98), Expect = 0.001 Identities = 24/76 (31%), Positives = 40/76 (52%), Gaps = 2/76 (2%) Frame = +1 Query: 307 NDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 + +++++LG GTY +V+ G+ R G VA+K I +G PS R E + Sbjct: 4 SSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIR-------EISL 56 Query: 481 LSSLHHPNVVSFYGVV 528 + L H N+V+ Y V+ Sbjct: 57 MKELKHENIVTLYDVI 72
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 42.4 bits (98), Expect = 0.001 Identities = 27/79 (34%), Positives = 43/79 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 88 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 140 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 141 FMGYM---TKDNLAIVTQW 156
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 42.4 bits (98), Expect = 0.001 Identities = 29/75 (38%), Positives = 39/75 (52%), Gaps = 5/75 (6%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +GSG G V +G+ R VAIK +KA +ER+R DF +EA I+ Sbjct: 6 KIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGY-----TERQR--QDFLREAAIMGQF 58 Query: 493 HHPNVVSFYGVVRDG 537 HPN++ GVV G Sbjct: 59 DHPNIIRLEGVVTRG 73
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 + ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V + V+ + L V EF Sbjct: 56 KELNHPNIVKLHDVIH--TENKLYLVFEF 82
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 42.4 bits (98), Expect = 0.001 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 5/76 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 539 IEEV--IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY-----SEKQR--RDFLSEASI 589 Query: 481 LSSLHHPNVVSFYGVV 528 + HPN++ GVV Sbjct: 590 MGQFDHPNIIRLEGVV 605
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 42.4 bits (98), Expect = 0.001 Identities = 27/79 (34%), Positives = 43/79 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 408 FMGYM---TKDNLAIVTQW 423
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 42.4 bits (98), Expect = 0.001 Identities = 27/79 (34%), Positives = 43/79 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEF 570 F G + +LA VT++ Sbjct: 408 FMGYM---TKDNLAIVTQW 423
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/89 (31%), Positives = 45/89 (50%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + R + + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKARHRPSGLIMAR-KLIHLEIKPAVRNQII----RELQV 121 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 L + P +V FYG DG ++ E Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICME 148
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/75 (38%), Positives = 38/75 (50%), Gaps = 5/75 (6%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +GSG G V +G+ R VAIK +KA +ER+R DF EA I+ Sbjct: 639 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-----TERQR--RDFLSEASIMGQF 691 Query: 493 HHPNVVSFYGVVRDG 537 HPN++ GVV G Sbjct: 692 DHPNIIRLEGVVTRG 706
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/89 (31%), Positives = 46/89 (51%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 56 LKDDDFEKISELGAGNGGVVFKVSHKPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 110 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 L + P +V FYG DG ++ E Sbjct: 111 LHECNSPYIVGFYGAFYS--DGEISICME 137
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 42.0 bits (97), Expect = 0.001 Identities = 27/89 (30%), Positives = 46/89 (51%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E++ ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 62 LKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMAR-KLIHLEIKPAIRNQII----RELQV 116 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 L + P +V FYG DG ++ E Sbjct: 117 LHECNSPYIVGFYGAFYS--DGEISICME 143
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 42.0 bits (97), Expect = 0.001 Identities = 34/102 (33%), Positives = 46/102 (45%), Gaps = 9/102 (8%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQT-------IKNDDLEEIKELGSGTYGSVFHGK--WRGCDV 390 K S ES+P + E S+G + K LG+GT+G V K G DV Sbjct: 4 KVSEKESSPKQTEEDSEGKMAHVQPASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDV 63 Query: 391 AIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSF 516 A+K + G + E L + E IL LHHPN+V+F Sbjct: 64 AVKILIKKALKGNKVQLEAL----YDELDILQRLHHPNIVAF 101
>KSR2_HUMAN (Q6VAB6) Kinase suppressor of ras-2 (hKSR2)| Length = 829 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/103 (31%), Positives = 46/103 (44%), Gaps = 2/103 (1%) Frame = +1 Query: 256 STPAEAEALSKGLQT--IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 S P +A S LQ I + LE + +G G +G V+HG+W G +VAI+ I Sbjct: 523 SFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIE----- 576 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 558 + E + F +E H NVV F G P ++ T Sbjct: 577 -RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIIT 618
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 1/86 (1%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSL 492 LEE+ +G G +G V+ G WRG VA+K + P E + A+ +EA++ + L Sbjct: 119 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQD-----PDEDISVTAESVRQEARLFAML 171 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 HPN+++ V + P +L V E+ Sbjct: 172 AHPNIIALKAVCLEEP--NLCLVMEY 195
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/97 (31%), Positives = 47/97 (48%), Gaps = 7/97 (7%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCD-------VAIKRIKASCFDGRPSERERLIAD 459 IK D+ ELG G +G VF + VA+K +K + + R D Sbjct: 508 IKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQ--------D 559 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +EA++L+ L H ++V F+GV +G G L V E+ Sbjct: 560 FHREAELLTMLQHQHIVRFFGVCTEG--GPLLMVFEY 594
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 +++++LG GTYG V+ K + G VA+K+I+ DG PS R E +L + Sbjct: 11 QKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLE-DDGVPSTALR-------EISLLKEV 62 Query: 493 HHPNVVSFYGVV 528 HPNVVS + V+ Sbjct: 63 PHPNVVSLFDVL 74
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 8/100 (8%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC--------DVAIKRI 405 + + P++AE S L D L K LGSG +G V+ G VA+K + Sbjct: 78 VSTLPSQAEIES--LPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTL 135 Query: 406 KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 K D SE F KEA ++S HP+++ GV Sbjct: 136 KRGATDQEKSE-------FLKEAHLMSKFDHPHILKLLGV 168
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 41.6 bits (96), Expect = 0.002 Identities = 29/75 (38%), Positives = 38/75 (50%), Gaps = 5/75 (6%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +GSG G V +G+ R VAIK +KA +ER+R DF EA I+ Sbjct: 638 KIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGY-----TERQR--QDFLSEAAIMGQF 690 Query: 493 HHPNVVSFYGVVRDG 537 HPN++ GVV G Sbjct: 691 DHPNIIRLEGVVTRG 705
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 8/100 (8%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC--------DVAIKRI 405 + + P++AE S L D L K LGSG +G V+ G VA+K + Sbjct: 1941 VSTLPSQAEIES--LPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTL 1998 Query: 406 KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 525 K D SE F KEA ++S HP+++ GV Sbjct: 1999 KRGATDQEKSE-------FLKEAHLMSKFDHPHILKLLGV 2031
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 41.6 bits (96), Expect = 0.002 Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 1/76 (1%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSL 492 LEEI +G G +G V+ WRG +VA+K + P + + A+ +EA++ +L Sbjct: 100 LEEI--IGVGGFGKVYRALWRGEEVAVKAARLD-----PEKDPAVTAEQVCQEARLFGAL 152 Query: 493 HHPNVVSFYGVVRDGP 540 HPN+++ G + P Sbjct: 153 QHPNIIALRGACLNPP 168
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 3/100 (3%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCF 420 +ES E SKG + DL ++ + SG + ++ G ++ VA+K ++ Sbjct: 61 LESENVETWEASKGEREEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTH 120 Query: 421 DGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 540 + R +L F E +LS L HPN+V F + P Sbjct: 121 --KEETRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKPP 158
>MOS_HUMAN (P00540) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 41.2 bits (95), Expect = 0.002 Identities = 25/75 (33%), Positives = 37/75 (49%) Frame = +1 Query: 325 IKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 ++ LG+G +GSV+ +RG VAIK++ C R + R FW E + + L H N Sbjct: 63 LQRLGAGGFGSVYKATYRGVPVAIKQVN-KCTKNRLASRR----SFWAELNV-ARLRHDN 116 Query: 505 VVSFYGVVRDGPDGS 549 +V P GS Sbjct: 117 IVRVVAASTRTPAGS 131
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 41.2 bits (95), Expect = 0.002 Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 5/122 (4%) Frame = +1 Query: 169 GKKFDENTD---GDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELG 339 GK +ENT D D++ SC + + T E + L D ++LG Sbjct: 23 GKNTNENTSKQSNDYKYDINTSCISREGT----TTLERKNLILCHSGKLEDKYIIDEKLG 78 Query: 340 SGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERL--IADFWKEAQILSSLHHPNVVS 513 GTYG V+ G I ++ + + +++RL I F++E +I+ L HPN+V Sbjct: 79 QGTYGCVYKG--------IDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVK 130 Query: 514 FY 519 Y Sbjct: 131 LY 132
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 41.2 bits (95), Expect = 0.002 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 1/86 (1%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSER-ERLIADFWKEAQILSSL 492 LEEI +G G +G V+ W G +VA+K + P E + I + +EA++ + L Sbjct: 146 LEEI--IGIGGFGKVYRAFWIGDEVAVKAARHD-----PDEDISQTIENVRQEAKLFAML 198 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEF 570 HPN+++ GV P +L V EF Sbjct: 199 KHPNIIALRGVCLKEP--NLCLVMEF 222
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 41.2 bits (95), Expect = 0.002 Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 5/122 (4%) Frame = +1 Query: 169 GKKFDENTD---GDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELG 339 GK +ENT D D++ SC + + T E + L D ++LG Sbjct: 23 GKNTNENTSKQSNDYKYDINTSCISREGT----TTLERKNLILCHSGKLEDKYIIDEKLG 78 Query: 340 SGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERL--IADFWKEAQILSSLHHPNVVS 513 GTYG V+ G I ++ + + +++RL I F++E +I+ L HPN+V Sbjct: 79 QGTYGCVYKG--------IDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVK 130 Query: 514 FY 519 Y Sbjct: 131 LY 132
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 41.2 bits (95), Expect = 0.002 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 5/76 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 481 LSSLHHPNVVSFYGVV 528 + HPN++ GVV Sbjct: 672 MGQFDHPNIIRLEGVV 687
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 41.2 bits (95), Expect = 0.002 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 5/76 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 481 LSSLHHPNVVSFYGVV 528 + HPN++ GVV Sbjct: 672 MGQFDHPNIIRLEGVV 687
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 41.2 bits (95), Expect = 0.002 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 5/76 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 481 LSSLHHPNVVSFYGVV 528 + HPN++ GVV Sbjct: 672 MGQFDHPNIIRLEGVV 687
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 41.2 bits (95), Expect = 0.002 Identities = 28/89 (31%), Positives = 44/89 (49%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + R + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKARHRPSGFIMAR-KLIHLEIKPAVRNQII----RELQV 121 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 L + P +V FYG DG ++ E Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICME 148
>NIMA_EMENI (P11837) G2-specific protein kinase nimA (EC 2.7.11.1) (Never in| mitosis) Length = 699 Score = 41.2 bits (95), Expect = 0.002 Identities = 23/70 (32%), Positives = 39/70 (55%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 D E ++++G G++G + K + + R + + ERE+L A+F ILSS Sbjct: 9 DKYEVLEKIGCGSFGIIRKVKRKSDGFILCRKEINYIKMSTKEREQLTAEF----NILSS 64 Query: 490 LHHPNVVSFY 519 L HPN+V++Y Sbjct: 65 LRHPNIVAYY 74
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V V+ + L V EF Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEF 82
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 2/93 (2%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERER 447 E + + L + +++ +++ +GSG G+VF G++ G +VA+K+++ Sbjct: 142 EHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD------------ 189 Query: 448 LIADFWKEAQI--LSSLHHPNVVSFYGVVRDGP 540 KE I L L HPN+++F GV P Sbjct: 190 -----LKETDIKHLRKLKHPNIITFKGVCTQAP 217
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 2/93 (2%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERER 447 E + + L + +++ +++ +GSG G+VF G++ G +VA+K+++ Sbjct: 142 EHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD------------ 189 Query: 448 LIADFWKEAQI--LSSLHHPNVVSFYGVVRDGP 540 KE I L L HPN+++F GV P Sbjct: 190 -----LKETDIKHLRKLKHPNIITFKGVCTQAP 217
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 40.8 bits (94), Expect = 0.003 Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 3/90 (3%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASC-FDGRPSERERLIADFWKEAQI 480 D ++++++G GTYG V+ K R G VA+K+I+ +G PS R E + Sbjct: 2 DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIR-------EISL 54 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L L HPN+V VV + + L V EF Sbjct: 55 LKELKHPNIVRLLDVVHN--ERKLYLVFEF 82
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ + R G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V V+ + L V EF Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEF 82
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V V+ + L V EF Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEF 82
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ K G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V V+ + L V EF Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEF 82
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V V+ + L V EF Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEF 82
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 L+HPN+V V+ + L V EF Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEF 82
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 40.8 bits (94), Expect = 0.003 Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 3/78 (3%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFD-GRPSERERLIADFWKEAQI 480 +D E+I+++G GTYG V+ G+ R G VA+K+I+ D G PS R E + Sbjct: 2 EDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIR-------EISL 54 Query: 481 LSSLHHPNVVSFYGVVRD 534 L L H N+V V+ + Sbjct: 55 LKELKHENIVCLEDVLME 72
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 2/93 (2%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERER 447 E + + L + +++ +++ +GSG G+VF G++ G +VA+K+++ Sbjct: 109 EHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD------------ 156 Query: 448 LIADFWKEAQI--LSSLHHPNVVSFYGVVRDGP 540 KE I L L HPN+++F GV P Sbjct: 157 -----LKETDIKHLRKLKHPNIITFKGVCTQAP 184
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 40.8 bits (94), Expect = 0.003 Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 2/99 (2%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLI 453 LS GL+ + D + LG GTYG V+ R G VA+K+++ D E + Sbjct: 12 LSSGLKD-QFDRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTD------EGIP 64 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 +E IL +HHPN+V+ V+ DG L + E+ Sbjct: 65 QTALREVSILQEIHHPNIVNLLDVI--CADGKLYLIFEY 101
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 40.4 bits (93), Expect = 0.004 Identities = 36/145 (24%), Positives = 61/145 (42%), Gaps = 17/145 (11%) Frame = +1 Query: 151 CDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKND-----D 315 C + K F + + +G +K+S E A++ G+ K + Sbjct: 2 CSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNS-------EDLAINPGMYVRKKEGKIGES 54 Query: 316 LEEIKELGSGTYGSVF-----HGKWRGCDVAIKRIKASCFD-------GRPSERERLIAD 459 ++++LGSG YG V HG + AIK IK S FD + +++ + Sbjct: 55 YFKVRKLGSGAYGEVLLCREKHGHG---EKAIKVIKKSQFDKMKYSITNKIECDDKIHEE 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRD 534 + E +L SL HPN++ + V D Sbjct: 112 IYNEISLLKSLDHPNIIKLFDVFED 136
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 40.4 bits (93), Expect = 0.004 Identities = 36/145 (24%), Positives = 61/145 (42%), Gaps = 17/145 (11%) Frame = +1 Query: 151 CDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKND-----D 315 C + K F + + +G +K+S E A++ G+ K + Sbjct: 2 CSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNS-------EDLAINPGMYVRKKEGKIGES 54 Query: 316 LEEIKELGSGTYGSVF-----HGKWRGCDVAIKRIKASCFD-------GRPSERERLIAD 459 ++++LGSG YG V HG + AIK IK S FD + +++ + Sbjct: 55 YFKVRKLGSGAYGEVLLCREKHGHG---EKAIKVIKKSQFDKMKYSITNKIECDDKIHEE 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRD 534 + E +L SL HPN++ + V D Sbjct: 112 IYNEISLLKSLDHPNIIKLFDVFED 136
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/65 (32%), Positives = 37/65 (56%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 + +GSG++G+V+ GKW G DVA+K + + P+ ++ + F E +L H N+ Sbjct: 71 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTA----PTPQQ--LQAFKNEVGVLRKTRHVNI 123 Query: 508 VSFYG 522 + F G Sbjct: 124 LLFMG 128
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/65 (32%), Positives = 37/65 (56%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 + +GSG++G+V+ GKW G DVA+K + + P+ ++ + F E +L H N+ Sbjct: 501 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTA----PTPQQ--LQAFKNEVGVLRKTRHVNI 553 Query: 508 VSFYG 522 + F G Sbjct: 554 LLFMG 558
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 40.4 bits (93), Expect = 0.004 Identities = 28/62 (45%), Positives = 37/62 (59%), Gaps = 2/62 (3%) Frame = +1 Query: 334 LGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 LGSG +G V+ GK R G DVAIK I F P+++E + + E IL +LHHP V Sbjct: 589 LGSGQFGIVYGGKHRKTGRDVAIKIIDKLRF---PTKQESQLRN---EVAILQNLHHPGV 642 Query: 508 VS 513 V+ Sbjct: 643 VN 644
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 40.4 bits (93), Expect = 0.004 Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 2/84 (2%) Frame = +1 Query: 325 IKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 ++ +G G+YG V K R G IK++ S RER A+ +EAQ+LS L H Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLR----NASSRERRAAE--QEAQLLSQLKH 62 Query: 499 PNVVSFYGVVRDGPDGSLATVTEF 570 PN+V+ Y +G DG L V F Sbjct: 63 PNIVT-YKESWEGGDGLLYIVMGF 85
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/62 (43%), Positives = 37/62 (59%), Gaps = 2/62 (3%) Frame = +1 Query: 334 LGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 LGSG +G V+ GK R G DVAIK I F P+++E + + E IL +LHHP + Sbjct: 582 LGSGQFGIVYGGKHRKTGRDVAIKVIDKMRF---PTKQESQLRN---EVAILQNLHHPGI 635 Query: 508 VS 513 V+ Sbjct: 636 VN 637
>E2AK4_HUMAN (Q9P2K8) Eukaryotic translation initiation factor 2-alpha kinase 4| (EC 2.7.11.1) (GCN2-like protein) Length = 1649 Score = 40.4 bits (93), Expect = 0.004 Identities = 25/71 (35%), Positives = 37/71 (52%), Gaps = 2/71 (2%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 486 + EE++ LG G +G+V K GC A+KRI + P+ R+ E +LS Sbjct: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPIN-----PASRQ--FRRIKGEVTLLS 641 Query: 487 SLHHPNVVSFY 519 LHH N+V +Y Sbjct: 642 RLHHENIVRYY 652
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/65 (32%), Positives = 37/65 (56%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 + +GSG++G+V+ GKW G DVA+K + + P+ ++ + F E +L H N+ Sbjct: 23 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTA----PTPQQ--LQAFKNEVGVLRKTRHVNI 75 Query: 508 VSFYG 522 + F G Sbjct: 76 LLFMG 80
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/65 (32%), Positives = 37/65 (56%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 + +GSG++G+V+ GKW G DVA+K + + P+ ++ + F E +L H N+ Sbjct: 501 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTA----PTPQQ--LQAFKNEVGVLRKTRHVNI 553 Query: 508 VSFYG 522 + F G Sbjct: 554 LLFMG 558
>MOS_CERAE (P10650) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 40.4 bits (93), Expect = 0.004 Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 2/100 (2%) Frame = +1 Query: 256 STPAEAEALSKGLQ--TIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 +TP A L + L +I + + ++ LG+G +GSV+ + G VAIK++ C R Sbjct: 38 ATPPRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYHGVPVAIKQVN-KCTKNR 96 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS 549 + R FW E + + L H N+V P GS Sbjct: 97 LASRR----SFWAELNV-ARLRHDNIVRVVAASTRTPAGS 131
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/62 (43%), Positives = 37/62 (59%), Gaps = 2/62 (3%) Frame = +1 Query: 334 LGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 LGSG +G V+ GK R G DVAIK I F P+++E + + E IL +LHHP + Sbjct: 581 LGSGQFGIVYGGKHRKTGRDVAIKVIDKMRF---PTKQESQLRN---EVAILQNLHHPGI 634 Query: 508 VS 513 V+ Sbjct: 635 VN 636
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 40.4 bits (93), Expect = 0.004 Identities = 42/168 (25%), Positives = 70/168 (41%), Gaps = 7/168 (4%) Frame = +1 Query: 52 LPEFVASVKKAALEESEKPVEVQPDARPANSPVCDNDKDGKKFDEN---TDGDQDPDVH- 219 +P+ V + + + S+KP P RPA + G + N T P+V Sbjct: 55 VPQRVLAQAQKPILSSQKPTTQIP-LRPATQGHQSSKPQGPNENRNPQQTSHSSTPNVEK 113 Query: 220 -GSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--V 390 GS DQ K+S + + + +D E + LG G +G+V+ + R + Sbjct: 114 KGSTDQGKTSAVPKEEGKKKQWCL-------EDFEIGRPLGKGKFGNVYLARERESKFIL 166 Query: 391 AIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRD 534 A+K + S + E + +E +I S L HPN++ YG D Sbjct: 167 ALKVLFKSQLEKAGVEHQ-----LRREVEIQSHLRHPNILRLYGYFHD 209
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/65 (32%), Positives = 37/65 (56%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 + +GSG++G+V+ GKW G DVA+K + + P+ ++ + F E +L H N+ Sbjct: 87 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTA----PTPQQ--LQAFKNEVGVLRKTRHVNI 139 Query: 508 VSFYG 522 + F G Sbjct: 140 LLFMG 144
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/62 (37%), Positives = 35/62 (56%) Frame = +1 Query: 325 IKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 ++ LGSG +GSV+ +RG VA+K++K S + S + FW E + L HP+ Sbjct: 66 LEPLGSGGFGSVYRATYRGETVALKKVKRSTKNSLASRQ-----SFWAELN-AARLRHPH 119 Query: 505 VV 510 VV Sbjct: 120 VV 121
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 40.4 bits (93), Expect = 0.004 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 3/87 (3%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFD-GRPSERERLIADFWKEAQILSS 489 E+++++G GTYG+VF K R VA+KR++ D G PS R E +L Sbjct: 5 EKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALR-------EICLLKE 57 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEF 570 L H N+V + V+ D L V EF Sbjct: 58 LKHKNIVRLHDVLHS--DKKLTLVFEF 82
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 40.4 bits (93), Expect = 0.004 Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 7/86 (8%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVF----HGKWRGCD---VAIKRIKASCFDGRPSERERLIAD 459 IK D+ ELG G +G VF H D VA+K +K + R D Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ--------D 556 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDG 537 F +EA++L+ L H ++V F+GV +G Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTEG 582
>KSR1_MOUSE (Q61097) Kinase suppressor of ras-1 (Kinase suppressor of ras)| (mKSR1) (Hb protein) Length = 873 Score = 40.4 bits (93), Expect = 0.004 Identities = 47/183 (25%), Positives = 78/183 (42%), Gaps = 4/183 (2%) Frame = +1 Query: 34 ENRLNFLPEFVASVKKAALEESEKPVEV--QP--DARPANSPVCDNDKDGKKFDENTDGD 201 ++R +F P+ A + A L + + QP D + + + GK E+ + D Sbjct: 468 DSRFSF-PDISACSQAAPLSSTADSTRLDDQPKTDVLGVHEAEAEEPEAGKSEAEDDEED 526 Query: 202 QDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG 381 + D+ S + G S A ++ I + +E + +G G +G V G+W G Sbjct: 527 EVDDLPSS--RRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG 584 Query: 382 CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATV 561 +VAI+ ++ DG + +L F KE H NVV F G + P LA + Sbjct: 585 -EVAIRLLE---MDGHNQDHLKL---FKKEVMNYRQTRHENVVLFMGACMNPP--HLAII 635 Query: 562 TEF 570 T F Sbjct: 636 TSF 638
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/65 (32%), Positives = 37/65 (56%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 + +GSG++G+V+ GKW G DVA+K + + P+ ++ + F E +L H N+ Sbjct: 461 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTA----PTPQQ--LQAFKNEVGVLRKTRHVNI 513 Query: 508 VSFYG 522 + F G Sbjct: 514 LLFMG 518
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 40.4 bits (93), Expect = 0.004 Identities = 28/62 (45%), Positives = 37/62 (59%), Gaps = 2/62 (3%) Frame = +1 Query: 334 LGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 LGSG +G V+ GK R G DVAIK I F P+++E + + E IL +LHHP V Sbjct: 595 LGSGQFGIVYGGKHRKTGRDVAIKIIDKLRF---PTKQESQLRN---EVAILQNLHHPGV 648 Query: 508 VS 513 V+ Sbjct: 649 VN 650
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/89 (31%), Positives = 45/89 (50%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + R + + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKVQHRPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 121 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 L + P +V FYG DG ++ E Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICME 148
>E2AK2_SCHPO (Q9UTE5) Eukaryotic translation initiation factor 2-alpha kinase 2| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor 2) Length = 639 Score = 40.0 bits (92), Expect = 0.005 Identities = 21/72 (29%), Positives = 40/72 (55%), Gaps = 2/72 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFH--GKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D EE LG G +GSV+H K G + A+K+I ++ ++ + ++E + L Sbjct: 169 EDFEEYSLLGRGGFGSVYHVRNKIDGAEYAMKKINSTF-------QQMSYSKIFREIKCL 221 Query: 484 SSLHHPNVVSFY 519 + + HPNV+ ++ Sbjct: 222 AKMDHPNVIRYF 233
>NIM1_NEUCR (P48479) G2-specific protein kinase nim-1 (EC 2.7.11.1)| Length = 779 Score = 40.0 bits (92), Expect = 0.005 Identities = 22/72 (30%), Positives = 41/72 (56%) Frame = +1 Query: 304 KNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++D E ++++G G++G + + + + + R + S ERE+L A+F IL Sbjct: 3 ESDKYELLEKIGHGSFGIIRKVRRKADGMILCRKEISYLKMSQKEREQLHAEF----SIL 58 Query: 484 SSLHHPNVVSFY 519 S+L HPN+V +Y Sbjct: 59 STLRHPNIVGYY 70
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 40.0 bits (92), Expect = 0.005 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 7/88 (7%) Frame = +1 Query: 328 KELGSGTYGSV-----FHGKWRG--CDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 486 K LG G +G V FH K R VA+K +K + PSE L+++F +L Sbjct: 728 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA---SPSELRDLLSEF----NVLK 780 Query: 487 SLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++HP+V+ YG DG L + E+ Sbjct: 781 QVNHPHVIKLYGAC--SQDGPLLLIVEY 806
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 10/79 (12%) Frame = +1 Query: 331 ELGSGTYGSVFHGKWRGCD----------VAIKRIKASCFDGRPSERERLIADFWKEAQI 480 ELG G +G VF + C VA+K +K +E RL DF +EA++ Sbjct: 498 ELGEGAFGKVFLAE---CSHLLPEQEKTLVAVKALK------EVTENARL--DFQREAEL 546 Query: 481 LSSLHHPNVVSFYGVVRDG 537 L+ L H ++V FYGV +G Sbjct: 547 LTVLQHEHIVKFYGVCTEG 565
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 40.0 bits (92), Expect = 0.005 Identities = 22/75 (29%), Positives = 43/75 (57%), Gaps = 2/75 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVV 528 L+HPN+V V+ Sbjct: 56 KELNHPNIVKLLDVI 70
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 40.0 bits (92), Expect = 0.005 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 3/87 (3%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFD-GRPSERERLIADFWKEAQILSS 489 E+++++G GTYG+VF K R VA+KR++ D G PS R E +L Sbjct: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-------EICLLKE 57 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEF 570 L H N+V + V+ D L V EF Sbjct: 58 LKHKNIVRLHDVLHS--DKKLTLVFEF 82
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 40.0 bits (92), Expect = 0.005 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 3/87 (3%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFD-GRPSERERLIADFWKEAQILSS 489 E+++++G GTYG+VF K R VA+KR++ D G PS R E +L Sbjct: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-------EICLLKE 57 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEF 570 L H N+V + V+ D L V EF Sbjct: 58 LKHKNIVRLHDVLHS--DKKLTLVFEF 82
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 40.0 bits (92), Expect = 0.005 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 3/87 (3%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFD-GRPSERERLIADFWKEAQILSS 489 E+++++G GTYG+VF K R VA+KR++ D G PS R E +L Sbjct: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-------EICLLKE 57 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEF 570 L H N+V + V+ D L V EF Sbjct: 58 LKHKNIVRLHDVLHS--DKKLTLVFEF 82
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 40.0 bits (92), Expect = 0.005 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 3/87 (3%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFD-GRPSERERLIADFWKEAQILSS 489 E+++++G GTYG+VF K R VA+KR++ D G PS R E +L Sbjct: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-------EICLLKE 57 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEF 570 L H N+V + V+ D L V EF Sbjct: 58 LKHKNIVRLHDVLHS--DKKLTLVFEF 82
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 40.0 bits (92), Expect = 0.005 Identities = 33/102 (32%), Positives = 46/102 (45%), Gaps = 7/102 (6%) Frame = +1 Query: 286 KGLQTIKNDDLEEIKELGSGTYG------SVFHGKWRGCDVAIKR-IKASCFDGRPSERE 444 K + +N E I+ LGSGT+ V GKW + KR I + + R +E Sbjct: 157 KNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEM- 215 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F +E IL SLHHP VV + + + D L V E+ Sbjct: 216 -----FQREIDILKSLHHPGVVQCHEIFEN--DDELFIVMEY 250
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 40.0 bits (92), Expect = 0.005 Identities = 33/115 (28%), Positives = 52/115 (45%), Gaps = 2/115 (1%) Frame = +1 Query: 181 DENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSV 360 DE + G Q P V + P +A G T+ N +E K++G G + V Sbjct: 2 DEQSQGMQGPPV-----------TQFQPQKALRPDMGYNTLANFRIE--KKIGRGQFSEV 48 Query: 361 FHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFY 519 + G VA+K+++ FD ++ AD KE +L L+HPNV+ +Y Sbjct: 49 YRASCLLDGVPVALKKVQI--FDLMDAKAR---ADCIKEIDLLKQLNHPNVIKYY 98
>KSR1_HUMAN (Q8IVT5) Kinase suppressor of ras-1 (Kinase suppressor of ras)| Length = 921 Score = 40.0 bits (92), Expect = 0.005 Identities = 46/181 (25%), Positives = 75/181 (41%) Frame = +1 Query: 28 ISENRLNFLPEFVASVKKAALEESEKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQD 207 + EN N A+ A + + + + D A+ + + GK E+ D D+ Sbjct: 518 LKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAED-DEDEV 576 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D+ S + G S A ++ I + +E + +G G +G V G+W G + Sbjct: 577 DDLPSS--RRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG-E 633 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VAI+ ++ DG + +L F KE H NVV F G + P LA +T Sbjct: 634 VAIRLLE---MDGHNQDHLKL---FKKEVMNYRQTRHENVVLFMGACMNPP--HLAIITS 685 Query: 568 F 570 F Sbjct: 686 F 686
>MOS_APTAU (P87347) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 39.7 bits (91), Expect = 0.006 Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 2/81 (2%) Frame = +1 Query: 325 IKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 ++ LGSG +GSV+ + G VA+K++K S + S + FW E + + L H N Sbjct: 5 LQPLGSGGFGSVYKATYHGATVAVKQVKKSSKNRLASRQ-----SFWAELNV-ARLQHAN 58 Query: 505 VVSFYGVVRDGP--DGSLATV 561 VV P SL T+ Sbjct: 59 VVRVVAASTCAPASQNSLGTI 79
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 39.7 bits (91), Expect = 0.006 Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 4/143 (2%) Frame = +1 Query: 145 PVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEE 324 P CD D+ +N + P S ++KS + T + + + N D Sbjct: 126 PFCDKDRTLMTPVQNLEQSYMPP-DSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 184 Query: 325 IK----ELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 I ++G G +G V+ G VA+K++ A E L F +E ++++ Sbjct: 185 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMV----DITTEELKQQFDQEIKVMAKC 240 Query: 493 HHPNVVSFYGVVRDGPDGSLATV 561 H N+V G DG D L V Sbjct: 241 QHENLVELLGFSSDGDDLCLVYV 263
>TOPK_MOUSE (Q9JJ78) T-lymphokine-activated killer cell-originated protein| kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) Length = 330 Score = 39.7 bits (91), Expect = 0.006 Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 10/92 (10%) Frame = +1 Query: 325 IKELGSGTYGSVF----------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 +++LG GT SV+ H W A+K+I C D + ++ + D EA Sbjct: 34 MQKLGFGTGVSVYLMKRSPRGLSHSPW-----AVKKISLLCDDHYRTVYQKRLTD---EA 85 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 +IL +L+HPN++ Y + DGSL E+ Sbjct: 86 KILKNLNHPNIIG-YRAFTEASDGSLCLAMEY 116
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 39.7 bits (91), Expect = 0.006 Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 2/84 (2%) Frame = +1 Query: 325 IKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 ++ +G G+YG V K R G IK++ S RER A+ +EAQ+LS L H Sbjct: 9 MRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLR----NASSRERRAAE--QEAQLLSQLKH 62 Query: 499 PNVVSFYGVVRDGPDGSLATVTEF 570 PN+V+ Y +G DG L V F Sbjct: 63 PNIVT-YKESWEGGDGLLYIVMGF 85
>E2AK4_MOUSE (Q9QZ05) Eukaryotic translation initiation factor 2-alpha kinase 4| (EC 2.7.11.1) (GCN2-like protein) (mGCN2) Length = 1648 Score = 39.7 bits (91), Expect = 0.006 Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 2/71 (2%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 486 + EE++ LG G +G+V K GC A+KRI + P+ R E +LS Sbjct: 588 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPIN-----PASRH--FRRIKGEVTLLS 640 Query: 487 SLHHPNVVSFY 519 LHH N+V +Y Sbjct: 641 RLHHENIVRYY 651
>MERTK_MOUSE (Q60805) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 39.7 bits (91), Expect = 0.006 Identities = 27/71 (38%), Positives = 36/71 (50%), Gaps = 5/71 (7%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K LG G +GSV G + D VA+K +K F S+RE I +F EA + Sbjct: 586 KVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNF----SQRE--IEEFLSEAACMKDF 639 Query: 493 HHPNVVSFYGV 525 +HPNV+ GV Sbjct: 640 NHPNVIRLLGV 650
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 39.7 bits (91), Expect = 0.006 Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 2/83 (2%) Frame = +1 Query: 328 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 501 K LG G +G V+ + G ++A K+++ FD E + ++ E Q+L +L H Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQ---FDPDSPETSKEVSALECEIQLLKNLQHE 422 Query: 502 NVVSFYGVVRDGPDGSLATVTEF 570 +V +YG +RD + +L E+ Sbjct: 423 RIVQYYGCLRDRAEKTLTIFMEY 445
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 39.7 bits (91), Expect = 0.006 Identities = 24/83 (28%), Positives = 44/83 (53%), Gaps = 2/83 (2%) Frame = +1 Query: 328 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 501 K LG G +G V+ + G ++A+K+++ FD E + + E Q+L +L H Sbjct: 360 KLLGQGAFGRVYLCYDVDTGRELAVKQVQ---FDPDSPETSKEVNALECEIQLLKNLLHE 416 Query: 502 NVVSFYGVVRDGPDGSLATVTEF 570 +V +YG +RD + +L+ E+ Sbjct: 417 RIVQYYGCLRDPQEKTLSIFMEY 439
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 39.7 bits (91), Expect = 0.006 Identities = 27/91 (29%), Positives = 46/91 (50%), Gaps = 6/91 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 IL SL H N+V + GV +L + E+ Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEY 931 Score = 30.8 bits (68), Expect = 2.8 Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 1/91 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQ 477 I+N+DL + LG GT+ +F G R + K + R ++ F++ A Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAAS 599 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 ++S L H ++V YGV G + L V EF Sbjct: 600 MMSQLSHKHLVLNYGVCVCGEENIL--VQEF 628
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 39.7 bits (91), Expect = 0.006 Identities = 27/71 (38%), Positives = 38/71 (53%), Gaps = 2/71 (2%) Frame = +1 Query: 322 EIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLH 495 +I++LG GTYG V K R G VA+KRI+ SE E + +E +L L Sbjct: 6 KIEKLGEGTYGIVNKAKNRETGEIVALKRIRLD------SEDEGVPCTAIREISLLKELK 59 Query: 496 HPNVVSFYGVV 528 HPN+V + V+ Sbjct: 60 HPNIVRLHDVI 70
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 39.7 bits (91), Expect = 0.006 Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 5/77 (6%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 D+E ++ELG G +G V+ G+ VAIK +K + + DF +E + Sbjct: 409 DVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENA-------SVKTQQDFKREIE 461 Query: 478 ILSSLHHPNVVSFYGVV 528 ++S L H N+V GVV Sbjct: 462 LISDLKHQNIVCILGVV 478
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 39.7 bits (91), Expect = 0.006 Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 2/73 (2%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 + +++LG GTY V+ G+ R G VA+K I+ +G PS R E ++ L Sbjct: 4 QRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEGTPSTAIR-------EISLMKEL 56 Query: 493 HHPNVVSFYGVVR 531 HPN++S V++ Sbjct: 57 RHPNIMSLSDVLQ 69
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 39.7 bits (91), Expect = 0.006 Identities = 27/91 (29%), Positives = 46/91 (50%), Gaps = 6/91 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 IL SL H N+V + GV +L + E+ Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEY 931 Score = 30.4 bits (67), Expect = 3.7 Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 9/99 (9%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVF---------HGKWRGCDVAIKRIKASCFDGRPSERERLI 453 I+N+DL + LG GT+ +F +G+ +V +K + + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F++ A ++S L H ++V YGV G + L V EF Sbjct: 592 ESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL--VQEF 628
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 39.7 bits (91), Expect = 0.006 Identities = 27/91 (29%), Positives = 46/91 (50%), Gaps = 6/91 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 IL SL H N+V + GV +L + E+ Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEY 931 Score = 30.4 bits (67), Expect = 3.7 Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 9/99 (9%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVF---------HGKWRGCDVAIKRIKASCFDGRPSERERLI 453 I+N+DL + LG GT+ +F +G+ +V +K + + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 570 F++ A ++S L H ++V YGV G + L V EF Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL--VQEF 628 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.312 0.133 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 77,060,957 Number of Sequences: 219361 Number of extensions: 1505404 Number of successful extensions: 5831 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5071 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5540 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4757699440 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits)
