ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal39n21 |
|---|---|
| Clone Library Name | barley_pub |
>ATG1_NEUCR (Q7RX99) Serine/threonine-protein kinase atg-1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 932 Score = 197 bits (500), Expect = 3e-50 Identities = 103/245 (42%), Positives = 148/245 (60%), Gaps = 48/245 (19%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++++V+LG+H G VAVK + + RL+ KL+++L E+ IL+ + HP+I+ALHD + Sbjct: 31 GKGSFAKVYLGRHKVTGALVAVKSVELARLNKKLKENLYGEIQILKTLRHPHIVALHDCV 90 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRV---------------------PETVAKHFIRQ 310 I LI+EYC GDL ++ + ++ E V +HF++Q Sbjct: 91 ESSTHINLIMEYCELGDLSLFIKKRDKLITNPYTHDLARKYPVYPNAGLNEVVTRHFLKQ 150 Query: 311 LACGLQKLRESNVVHRDLKPQNILLV------SNNGTS---------------------I 409 LA LQ LR + VHRD+KPQN+LL+ +NN T+ + Sbjct: 151 LASALQFLRAGDFVHRDVKPQNLLLLPSPHMMANNKTAKHIMSGSYDSFTPAAGLASAPM 210 Query: 410 LKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPP 589 LK+ADFGFA+ L + LAETLCGSPLYMAPE+++ +KYDAKADLWSVG +LY++VTG PP Sbjct: 211 LKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVTGRPP 270 Query: 590 FNGDS 604 F + Sbjct: 271 FKASN 275
>ATG1_MAGGR (Q52EB3) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 982 Score = 194 bits (493), Expect = 2e-49 Identities = 96/245 (39%), Positives = 148/245 (60%), Gaps = 48/245 (19%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++QV++GKH G VA+K + + RL+ KL+++L E++IL+ + HP+I+ALHD + Sbjct: 26 GKGSFAQVYMGKHKVSGAAVAIKSVELARLNKKLKENLYGEINILKTLRHPHIVALHDCV 85 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVP---------------------ETVAKHFIRQ 310 I L++EYC GDL ++ + +++ E V +HF++Q Sbjct: 86 ESATHINLMMEYCELGDLSLFIKKREKLSTNPATHDMARKYPNVPNSGLNEVVIRHFLKQ 145 Query: 311 LACGLQKLRESNVVHRDLKPQNILLVSN---------------------------NGTSI 409 L+ L+ LRESN+VHRD+KPQN+LL+ + + Sbjct: 146 LSSALKFLRESNLVHRDVKPQNLLLLPSPEFREVNKLARPILTASQDSLVPVAGLASLPM 205 Query: 410 LKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPP 589 LK+ADFGFA+ L + LAETLCGSPLYMAPE+++ ++YDAKADLWSVG +L++++ G PP Sbjct: 206 LKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYERYDAKADLWSVGTVLFEMIVGRPP 265 Query: 590 FNGDS 604 F + Sbjct: 266 FRASN 270
>ATG1_COLLN (P87248) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Colletotrichum lindemuthianum kinase 1) Length = 675 Score = 192 bits (489), Expect = 5e-49 Identities = 99/239 (41%), Positives = 142/239 (59%), Gaps = 46/239 (19%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++QV+ G H VA+K + M RL+ KLR++L E+ IL+ + HP+I+ALHD + Sbjct: 32 GKGSFAQVYSGHHKNSKAAVAIKSVEMGRLNNKLRENLYGEIQILKTLRHPHIVALHDCV 91 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKR---------------------VPETVAKHFIRQ 310 I L++EYC GDL ++ + R + E V +HF++Q Sbjct: 92 ESATHINLVMEYCELGDLSFFIKKRDRHGTNAATEDMARKYPVTPGSGLHEVVTRHFLQQ 151 Query: 311 LACGLQKLRESNVVHRDLKPQNILLVSNNG-------------------------TSILK 415 LA L+ LRE N VHRD+KPQN+LL+ + G +LK Sbjct: 152 LASALKFLREKNYVHRDVKPQNLLLLPSPGFRKENSRPILTASNDSLIPNAGLASLPMLK 211 Query: 416 IADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPF 592 +ADFGFA+ L + LA+TLCGSPLYMAPE+++ ++YDAKADLWSVG +LY+++TG PPF Sbjct: 212 LADFGFARVLPSTSLADTLCGSPLYMAPEILRYERYDAKADLWSVGTVLYEMITGRPPF 270
>ATG1_YARLI (Q6C7U0) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 710 Score = 186 bits (472), Expect = 5e-47 Identities = 96/233 (41%), Positives = 143/233 (61%), Gaps = 36/233 (15%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V+ G+HVA G+ VA+K + +L+ KL ++L SE+ IL+++ HP+++ L D Sbjct: 14 GRGSFATVYKGEHVASGSPVAIKSVLRAKLNRKLLENLGSEISILKQMKHPHVVELLDFQ 73 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETV---------------------AKHFIRQ 310 +L++EYC GDL +L + K + ET+ +HF+ Q Sbjct: 74 ETPTHFHLVMEYCSLGDLSFFLKKKKELSETLPLVASLLRRYPSNTRGLHEELVRHFVHQ 133 Query: 311 LACGLQKLRESNVVHRDLKPQNILLVSNNGTS---------------ILKIADFGFAKFL 445 L+ L+ LR+ N+VHRD+KPQN+LL + + ILKIADFGFA+ L Sbjct: 134 LSAALEFLRQKNLVHRDIKPQNLLLCPPSLSEMDAQNANLYGRWELPILKIADFGFARIL 193 Query: 446 QPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 S LAETLCGSPLYMAPE+++ +KY+AKADLWSVG + Y++V G PPF ++ Sbjct: 194 PASALAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVTYEMVVGKPPFKANN 246
>ATG1_BOTCI (Q6H9I1) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Botryotinia fuckeliana putative kinase exons 1-3) Length = 952 Score = 183 bits (465), Expect = 3e-46 Identities = 93/242 (38%), Positives = 142/242 (58%), Gaps = 49/242 (20%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V+ G H+ G VA+K + + RL+ KL+D+L E++IL+ + HP+I+AL D Sbjct: 30 GKGSFATVYRGTHMPSGNLVAIKSVNLSRLNKKLKDNLYVEIEILKSLYHPHIVALIDCR 89 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVP---------------------ETVAKHFIRQ 310 I+L++EYC GDL ++ + R+ + V +HF +Q Sbjct: 90 ESASHIHLMMEYCELGDLSYFIKKRDRLADNPTLYDMVQKYPMPVEGGLNQVVVRHFFKQ 149 Query: 311 LACGLQKLRESNVVHRDLKPQNILLVSN----------------------------NGTS 406 L+ ++ LRE + VHRD+KPQN+LL+ + N Sbjct: 150 LSSAMEFLRERDFVHRDVKPQNLLLIPSPEWIAKRAKGGPEAMKASKESVVAMVGINSLP 209 Query: 407 ILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSP 586 +LK+ADFGFA+ L + LAETLCGSPLYMAPE+++ +KYDA+ADLWS+G +LY+++TG P Sbjct: 210 MLKLADFGFARSLPSTSLAETLCGSPLYMAPEILRYEKYDARADLWSIGTVLYEMMTGRP 269 Query: 587 PF 592 PF Sbjct: 270 PF 271
>ATG1_SCHPO (Q9Y7T4) Serine/threonine-protein kinase atg1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 830 Score = 183 bits (464), Expect = 4e-46 Identities = 93/229 (40%), Positives = 141/229 (61%), Gaps = 36/229 (15%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V+ GKH +++K + +L+ KL ++L SE+ IL+ I H +++ L D I Sbjct: 21 GRGSFAIVYKGKHTETNRVISIKSVLTKKLTKKLLENLESEISILKEIRHVHVVELIDCI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKR---------------------VPETVAKHFIRQ 310 + G I+L++EYC GDL ++ + ++ + ET+ +HF +Q Sbjct: 81 KAGRFIHLVMEYCSLGDLSYFIRKREKFNSIPSLAWINIDHPPVYKAGLNETLVRHFTQQ 140 Query: 311 LACGLQKLRESNVVHRDLKPQNILL---------------VSNNGTSILKIADFGFAKFL 445 LA LQ LR +++HRD+KPQN+LL V + +LK+ADFGFA++L Sbjct: 141 LASALQFLRSRSLIHRDVKPQNLLLQPPPTAAYLEEHPQFVGSPKLPMLKLADFGFARYL 200 Query: 446 QPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPF 592 Q S +AETLCGSPLYMAPE+++ +KYDAKADLWSVG +LY++ G PPF Sbjct: 201 QTSSMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLYEMAVGKPPF 249
>ATG1_EMENI (Q5BCU8) Serine/threonine-protein kinase atg1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 935 Score = 182 bits (463), Expect = 5e-46 Identities = 97/244 (39%), Positives = 142/244 (58%), Gaps = 51/244 (20%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V+ G T VA+K + + +L+ KL+D+L E+DIL+ + HP+I+AL D + Sbjct: 31 GKGSFATVYRGVQTKSRTFVAIKSVNLGKLNRKLKDNLAMEIDILKYLLHPHIVALLDCL 90 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVP---------------------ETVAKHFIRQ 310 I+LI+EYC GDL ++ R + E + +HF++Q Sbjct: 91 ETNSHIHLIMEYCALGDLSQFIKRRDSLKDHSYTRHMISKYPNVSGGALNEVIVRHFLKQ 150 Query: 311 LACGLQKLRESNVVHRDLKPQNILL-------------------VSNNGTS--------- 406 LA L+ LR+ N++HRD+KPQN+LL + + TS Sbjct: 151 LASALRFLRDKNLIHRDIKPQNLLLCPAPKPAPTQSEAEPQIVPLKGSETSFTPAVGLET 210 Query: 407 --ILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTG 580 +LK+ADFGFA+ L + LAETLCGSPLYMAPE+++ +KYDAKADLWSVG +LY++V G Sbjct: 211 LPLLKLADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVG 270 Query: 581 SPPF 592 PPF Sbjct: 271 KPPF 274
>ATG1_ASPFU (Q4WPF2) Serine/threonine-protein kinase atg1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 973 Score = 182 bits (463), Expect = 5e-46 Identities = 97/241 (40%), Positives = 139/241 (57%), Gaps = 48/241 (19%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V+ G H T VA+K + + +L+ KL+D+L SE+ IL+ + HP+I+AL D Sbjct: 30 GRGSFATVYQGVHTKTRTYVAIKSVNLSKLNKKLKDNLSSEIHILKGLYHPHIVALIDCH 89 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHK---------------------RVPETVAKHFIRQ 310 I+L++EYC GDL ++ R + E V +HF++Q Sbjct: 90 ETTSHIHLVMEYCALGDLSLFIKRRDTLGDHRYTRDMIAKYPNPPGGALNEVVVRHFLKQ 149 Query: 311 LACGLQKLRESNVVHRDLKPQNILLVSN---------------------------NGTSI 409 LA L+ LR+ N++HRD+KPQN+LL + + Sbjct: 150 LASALKFLRDRNLIHRDIKPQNLLLCPSPSSYRSGVTQVVPFKGSEDSFNPATGLESLPL 209 Query: 410 LKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPP 589 LKIADFGFA+ L + LAETLCGSPLYMAPE+++ +KYDAKADLWSVG +LY++V G PP Sbjct: 210 LKIADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGKPP 269 Query: 590 F 592 F Sbjct: 270 F 270
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 177 bits (448), Expect = 3e-44 Identities = 94/204 (46%), Positives = 130/204 (63%), Gaps = 7/204 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVAR-GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G GA++ V+ G+H + EVAVK I L AK + L E+ IL+ + H NI+AL+D Sbjct: 23 GHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYDF 81 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +YL++EYC GGDL YL + + E + F++Q+A ++ L ++HRDLKP Sbjct: 82 QEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKP 141 Query: 371 QNILLVSNNGTSI------LKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAK 532 QNILL + G +KIADFGFA++LQ + +A TLCGSP+YMAPEV+ +Q YD K Sbjct: 142 QNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGK 201 Query: 533 ADLWSVGIILYQLVTGSPPFNGDS 604 ADLWS+G I+YQ +TG PF S Sbjct: 202 ADLWSIGTIVYQCLTGKAPFQASS 225
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 176 bits (446), Expect = 5e-44 Identities = 94/204 (46%), Positives = 131/204 (64%), Gaps = 7/204 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVAR-GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G GA++ V+ G+H + EVAVK I L AK + L E+ IL+ + H NI+AL+D Sbjct: 23 GHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYDF 81 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +YL++EYC GGDL YL + + E + F++Q+A ++ L ++HRDLKP Sbjct: 82 QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKP 141 Query: 371 QNILLVS------NNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAK 532 QNILL + N + +KIADFGFA++LQ + +A TLCGSP+YMAPEV+ +Q YD K Sbjct: 142 QNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGK 201 Query: 533 ADLWSVGIILYQLVTGSPPFNGDS 604 ADLWS+G I+YQ +TG PF S Sbjct: 202 ADLWSIGTIVYQCLTGKAPFQASS 225
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 174 bits (442), Expect = 1e-43 Identities = 92/204 (45%), Positives = 129/204 (63%), Gaps = 7/204 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGT-EVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G GA++ V+ G+H + EVA+K I LS K + L E+ IL+ + H NI+AL+D Sbjct: 16 GHGAFAVVFRGRHRQKTDWEVAIKSINKKNLS-KSQILLGKEIKILKELQHENIVALYDV 74 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++L++EYC GGDL YL + E + F+ Q+A ++ L ++HRDLKP Sbjct: 75 QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKP 134 Query: 371 QNILLV------SNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAK 532 QNILL SN +KIADFGFA++L + +A TLCGSP+YMAPEV+ +Q YDAK Sbjct: 135 QNILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYDAK 194 Query: 533 ADLWSVGIILYQLVTGSPPFNGDS 604 ADLWS+G ++YQ + G PPF +S Sbjct: 195 ADLWSIGTVIYQCLVGKPPFQANS 218
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 174 bits (440), Expect = 2e-43 Identities = 90/204 (44%), Positives = 132/204 (64%), Gaps = 11/204 (5%) Frame = +2 Query: 14 GSGAYSQVWLGKHVAR-GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRIT---HPNIIAL 181 G GA++ V+ G++V R VA+K IA +S K ++ L E+ IL+ ++ H N++ L Sbjct: 16 GHGAFAIVYRGRYVDRTDVPVAIKAIAKKNIS-KSKNLLTKEIKILKELSSLKHENLVGL 74 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 +YL++E+C GGDL YL + + E +HF+ Q+A L+ + + +VHRD Sbjct: 75 LKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRD 134 Query: 362 LKPQNILLVSNNGTS-------ILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQK 520 LKPQNILL +N+ T ++K+ADFGFA+FL +A TLCGSP+YMAPEV+ + + Sbjct: 135 LKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQ 194 Query: 521 YDAKADLWSVGIILYQLVTGSPPF 592 YDAKADLWS+G IL+Q +TG PF Sbjct: 195 YDAKADLWSIGTILFQCLTGKAPF 218
>ATG1_CRYNE (Q5K8D3) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 988 Score = 173 bits (439), Expect = 3e-43 Identities = 90/241 (37%), Positives = 138/241 (57%), Gaps = 44/241 (18%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V+ G +A+K ++ +L++KL ++L SE++IL+ I H NI+AL D Sbjct: 34 GRGSFATVYKGYRSKTRVPIAIKAVSRQKLTSKLLENLESEINILKVINHRNIVALTDCF 93 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVP------------------------------- 280 ++ IYL++EYC G DL Y+ + +P Sbjct: 94 KNDTHIYLVMEYCSGSDLSVYIKQRGNIPTLDFVPKAGSSMALLPTDDEGKIYWPHPPTG 153 Query: 281 ---ETVAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNN----------GTSILKIA 421 E V + F+ QLA ++ LR +++HRD+KPQN+LL G +LK+A Sbjct: 154 GLDERVTRSFLGQLAQAIKFLRAQDLMHRDIKPQNLLLQPATETEVAEGHPYGIPVLKVA 213 Query: 422 DFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGD 601 DFGFA+ L + +AETLCGSPLYMAPE+++ +KYDAKADLWSVG +L+++ G PPF + Sbjct: 214 DFGFARILPAAAMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLFEMSVGRPPFRAN 273 Query: 602 S 604 + Sbjct: 274 N 274
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 173 bits (439), Expect = 3e-43 Identities = 91/204 (44%), Positives = 131/204 (64%), Gaps = 7/204 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGT-EVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G GA++ V+ G+H + EVA+K I LS K + L E+ IL+ + H NI+AL+D Sbjct: 16 GHGAFAVVFRGRHRQKTDWEVAIKSINKKNLS-KSQILLGKEIKILKELQHENIVALYDV 74 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++L++EYC GGDL YL + E + F+ Q+A ++ L ++HRDLKP Sbjct: 75 QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKP 134 Query: 371 QNILL--VSNNGTSI----LKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAK 532 QNILL + +S+ +KIADFGFA++L + +A TLCGSP+YMAPEV+ +Q YDAK Sbjct: 135 QNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAK 194 Query: 533 ADLWSVGIILYQLVTGSPPFNGDS 604 ADLWS+G ++YQ + G PPF +S Sbjct: 195 ADLWSIGTVIYQCLVGKPPFQANS 218
>ATG1_KLULA (Q6CSX2) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 831 Score = 169 bits (427), Expect = 7e-42 Identities = 96/240 (40%), Positives = 138/240 (57%), Gaps = 43/240 (17%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ G + G +A+K ++ +L + KL ++L E+ IL++I HP+I+ L D Sbjct: 28 GKGSFAVVYKGLSLRDGRNIAIKAVSRSKLKNKKLLENLEVEIAILKKIKHPHIVGLIDC 87 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVP------ETVAKHF----------------- 301 R YLI+EYC GDL ++ + K + +TV +H+ Sbjct: 88 ERTSSDFYLIMEYCALGDLTFFIKKRKNLVLKHPLIKTVFEHYPPPSTEHNGLNRVLVVN 147 Query: 302 -IRQLACGLQKLRESNVVHRDLKPQNILL------------------VSNNGTSILKIAD 424 ++QL+ L+ LR N+VHRD+KPQN+LL V ILKIAD Sbjct: 148 YLQQLSSALKFLRSKNLVHRDIKPQNLLLCTPLLDYNDPKTFHELGFVGIYNLPILKIAD 207 Query: 425 FGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 FGFA+FL + LAETLCGSPLYMAPE++ QKY+AKADLWSVG +LY++ G PPF + Sbjct: 208 FGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLYEMCCGRPPFKASN 267
>ATG1_USTMA (Q4P0K0) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 990 Score = 163 bits (412), Expect = 4e-40 Identities = 87/231 (37%), Positives = 134/231 (58%), Gaps = 38/231 (16%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G+++ V G + VA+K + +L+ KL D+L E+ IL+ I HPNI+ L + + Sbjct: 22 GKGSFAVVHKGYRLQPREPVAIKIVIRKKLTPKLLDNLEGEIAILKAIHHPNIVELKECL 81 Query: 194 RDGGRIYLILEYCRGGDLYAYLLR----HKR------------------------VPETV 289 + +IYL++ +C GDL Y+ + ++R + ET+ Sbjct: 82 KTEHQIYLVMAFCASGDLAQYIKKRFDIYERAGMAEPDSLTKGFKPTYPHPVDGGLNETI 141 Query: 290 AKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSI----------LKIADFGFAK 439 + + QLA L+ +R ++VHRD+KPQN+LL + + +K+ADFGFA+ Sbjct: 142 VRSILTQLAAALEFMRARDIVHRDIKPQNLLLQPPDAAFLALGNPREIPQMKVADFGFAR 201 Query: 440 FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPF 592 L + LAETLCGSPLYMAPE+++ +KYDAKADLWSVG +L+++ G PPF Sbjct: 202 HLSVNTLAETLCGSPLYMAPEILRFEKYDAKADLWSVGAVLFEMTVGKPPF 252
>ATG1_PICAN (Q8TFN2) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Peroxisome degradation deficient protein 7) Length = 804 Score = 163 bits (412), Expect = 4e-40 Identities = 91/236 (38%), Positives = 137/236 (58%), Gaps = 39/236 (16%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ G VAVK + RL + KL ++L E+ IL+ + +P+I+AL D Sbjct: 19 GRGSFANVYKGYDNRTKAPVAVKSVFRSRLKNQKLVENLEIEISILKNLKNPHIVALLDC 78 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPET-----------------------VAKHF 301 ++ +L +EYC GDL ++ R ++ +T + +F Sbjct: 79 VKTDQYFHLFMEYCSLGDLSYFIRRRDQLVQTHPLISSILERYPSPPNSHGLNKVLVVNF 138 Query: 302 IRQLACGLQKLRESNVVHRDLKPQNILL---------VSNNGTS------ILKIADFGFA 436 ++QLA L+ LR+ N+VHRD+KPQN+LL G S +LKIADFGFA Sbjct: 139 LKQLASALEFLRDQNLVHRDIKPQNLLLSPPVHSKEEFKRKGYSGLWELPVLKIADFGFA 198 Query: 437 KFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 +FL + +AETLCGSPLYMAPE+++ +KY+AKADLWSVG ++Y++ G PPF + Sbjct: 199 RFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVIYEMSVGKPPFRASN 254
>ATG1_PICPA (Q8TGI1) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Glucose-induced selective autophagy protein 10) (Pexophagy zeocin-resistant mutant protein 1) Length = 796 Score = 162 bits (411), Expect = 5e-40 Identities = 90/231 (38%), Positives = 136/231 (58%), Gaps = 38/231 (16%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ G + VA+K + RL + KL ++L E+ IL+ + HP+++AL D Sbjct: 16 GRGSFANVYKGYNSKTQVSVAIKSVIKSRLRNKKLIENLEVEISILKNLKHPHVVALLDC 75 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRH-----------------------KRVPETVAKHF 301 + +L++EYC GDL ++ + K + E + +F Sbjct: 76 EQSKHYFHLLMEYCSLGDLSYFITKREELISNHPLITGVFKKYPSPENSKGLNEVITINF 135 Query: 302 IRQLACGLQKLRESNVVHRDLKPQNILL---VSNN-----------GTSILKIADFGFAK 439 ++QLA L+ LR N+VHRD+KPQN+LL VS +LKIADFGFA+ Sbjct: 136 VQQLASALKFLRSQNLVHRDIKPQNLLLSPPVSREVFEDRKYTGLWELPVLKIADFGFAR 195 Query: 440 FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPF 592 FL + +AETLCGSPLYMAPE+++ +KY+AKADLWSVG ++Y++ G+PPF Sbjct: 196 FLPATSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVVYEMSVGTPPF 246
>ATG1_YEAST (P53104) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Autophagy protein 3) (Cytoplasm to vacuole targeting protein 10) Length = 897 Score = 162 bits (411), Expect = 5e-40 Identities = 96/241 (39%), Positives = 135/241 (56%), Gaps = 44/241 (18%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA-RGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHD 187 G G+++ V+ G + + VA+KE++ +L + KL ++L E+ IL++I HP+I+ L D Sbjct: 31 GKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLID 90 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPET------------------------VAK 295 R YLI+EYC GDL L R K + E Sbjct: 91 CERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVL 150 Query: 296 HFIRQLACGLQKLRESNVVHRDLKPQNILL------------------VSNNGTSILKIA 421 +++QLA L+ LR N+VHRD+KPQN+LL V ILKIA Sbjct: 151 SYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIA 210 Query: 422 DFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGD 601 DFGFA+FL + LAETLCGSPLYMAPE++ QKY+AKADLWSVG +++++ G+PPF Sbjct: 211 DFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRAS 270 Query: 602 S 604 + Sbjct: 271 N 271
>ATG1_CANAL (Q5A649) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 834 Score = 162 bits (409), Expect = 9e-40 Identities = 92/232 (39%), Positives = 132/232 (56%), Gaps = 39/232 (16%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ VA+K + +L S KL ++L E+ IL+ + HP+I+ L D Sbjct: 65 GKGSFATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQILKSMKHPHIVGLLDY 124 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHK--------------RVP---------ETVAKHF 301 + +L+++YC GDL ++ R R P E + HF Sbjct: 125 KQTTSYFHLVMDYCSMGDLSYFIRRRNNLVKSHPVISSLLHRYPSPEGSHGLNEVLVLHF 184 Query: 302 IRQLACGLQKLRESNVVHRDLKPQNILL---------------VSNNGTSILKIADFGFA 436 +RQL+ LQ LR+ ++VHRD+KPQN+LL V ILKIADFGFA Sbjct: 185 LRQLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKQEFIDGEFVGMWELPILKIADFGFA 244 Query: 437 KFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPF 592 +FL + +AETLCGSPLYMAPE+++ +KY+AKADLWSVG +LY++ G PPF Sbjct: 245 RFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPF 296
>ATG1_ASHGO (Q75CH3) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 972 Score = 161 bits (407), Expect = 2e-39 Identities = 94/242 (38%), Positives = 138/242 (57%), Gaps = 45/242 (18%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGT--EVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALH 184 G G+++ V+ G H+A + VA+K ++ +L + KL ++L E+ IL++I HP+I+ L Sbjct: 25 GRGSFAVVYKG-HLADSSAGNVAIKAVSRSKLRNKKLLENLEIEIAILKKIKHPHIVGLL 83 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLR------------------------HKRVPETVA 292 + R G YL++EYC GDL ++ + H + + Sbjct: 84 ECERTGTDFYLMMEYCALGDLTFFIKKRRSLMDKHPLVRTLFEKYPPPSEHHNGLNRVLV 143 Query: 293 KHFIRQLACGLQKLRESNVVHRDLKPQNILL------------------VSNNGTSILKI 418 ++++QL+ L+ LR N+VHRD+KPQN+LL V ILKI Sbjct: 144 VNYLQQLSSALKFLRSKNLVHRDIKPQNLLLSTPLVDYNDPAEFHARGFVGIYNLPILKI 203 Query: 419 ADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNG 598 ADFGFA+FL + LAETLCGSPLYMAPE++ QKY+AKADLWSVG +LY++ G PPF Sbjct: 204 ADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLYEMCCGKPPFKA 263 Query: 599 DS 604 + Sbjct: 264 SN 265
>ATG1_DEBHA (Q6BS08) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 875 Score = 160 bits (406), Expect = 2e-39 Identities = 91/237 (38%), Positives = 136/237 (57%), Gaps = 40/237 (16%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ + VA+K + +L S KL ++L E+ IL+ + HP+I+ L D Sbjct: 29 GKGSFATVYKCFNTKTNESVAIKSVVRSKLKSKKLVENLEIEISILKTMKHPHIVGLLDY 88 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHK---------------RVP---------ETVAKH 298 + +L+++YC GDL +Y +R + R P E + H Sbjct: 89 KQTTSHFHLVMDYCSMGDL-SYFIRKRNQLIKTHPVISSLLERYPSPEGSHGLNEVLVIH 147 Query: 299 FIRQLACGLQKLRESNVVHRDLKPQNILLV---------SNNG------TSILKIADFGF 433 F++QL L+ LR ++VHRD+KPQN+LL + G +LKIADFGF Sbjct: 148 FLKQLVSALEFLRNKSLVHRDIKPQNLLLCPPLHSKQEFKDGGFVGLWELPLLKIADFGF 207 Query: 434 AKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 A+FL + +AETLCGSPLYMAPE+++ +KY+AKADLWSVG +LY++ G PPF D+ Sbjct: 208 ARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFRADN 264
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 160 bits (405), Expect = 3e-39 Identities = 83/198 (41%), Positives = 122/198 (61%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +HV G EVAVK I +L+ L EV I++ + HPNI+ L + I Sbjct: 67 GKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI 126 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL++EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 127 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAE 186 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL +G +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 187 NLLL---DGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 243 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 244 GVILYTLVSGSLPFDGQN 261
>ATG1_CANGA (Q6FL58) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 942 Score = 159 bits (401), Expect = 8e-39 Identities = 96/242 (39%), Positives = 136/242 (56%), Gaps = 45/242 (18%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARG--TEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALH 184 G G+++ V+ G HV + +AVK +A +L + KL ++L E+ IL++I HP+I+ L Sbjct: 18 GKGSFATVYRG-HVTTDPKSHIAVKAVARSKLKNKKLLENLEIEIAILKKIKHPHIVGLI 76 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRV--------------PETVAKH-------- 298 D R YL+++YC GDL + + K + P +H Sbjct: 77 DCERTTTDFYLVMDYCALGDLTFLIKKRKELENNHPLLQTVFNKYPPPSKEHNGLNRAFV 136 Query: 299 --FIRQLACGLQKLRESNVVHRDLKPQNILL------------------VSNNGTSILKI 418 +++QLA L+ LR N+VHRD+KPQN+LL V ILKI Sbjct: 137 VCYLQQLASALKFLRSKNLVHRDIKPQNLLLATPLTNYRDSKTFHELGYVGIYNLPILKI 196 Query: 419 ADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNG 598 ADFGFA+FL + LAETLCGSPLYMAPE++ QKY+AKADLWSVG +L+++ G PPF Sbjct: 197 ADFGFARFLPSTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLFEMCCGVPPFTA 256 Query: 599 DS 604 + Sbjct: 257 SN 258
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 159 bits (401), Expect = 8e-39 Identities = 81/198 (40%), Positives = 122/198 (61%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +H+ G EVA+K I +L+ L EV I++ + HPNI+ L + I Sbjct: 63 GKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI 122 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YLI+EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 123 ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAE 182 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 183 NLLLDADMN---IKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 239 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 240 GVILYTLVSGSLPFDGQN 257
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 158 bits (399), Expect = 1e-38 Identities = 80/199 (40%), Positives = 121/199 (60%), Gaps = 1/199 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G +++V L +H+ G EVA+K I +L+ L EV I++ + HPNI+ L Sbjct: 63 RTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLF 122 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + I +YL++EY G+++ YL+ H R+ E A+ RQ+ + + N+VHRDL Sbjct: 123 EVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDL 182 Query: 365 KPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADL 541 K +N+LL + + +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+ Sbjct: 183 KAENLLL---DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDI 239 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G+ILY LV+GS PF+G Sbjct: 240 WSLGVILYTLVSGSLPFDG 258
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 158 bits (399), Expect = 1e-38 Identities = 80/199 (40%), Positives = 121/199 (60%), Gaps = 1/199 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G +++V L +H+ G EVA+K I +L+ L EV I++ + HPNI+ L Sbjct: 63 RTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLF 122 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + I +YL++EY G+++ YL+ H R+ E A+ RQ+ + + N+VHRDL Sbjct: 123 EVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDL 182 Query: 365 KPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADL 541 K +N+LL + + +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+ Sbjct: 183 KAENLLL---DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDI 239 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G+ILY LV+GS PF+G Sbjct: 240 WSLGVILYTLVSGSLPFDG 258
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 158 bits (399), Expect = 1e-38 Identities = 81/198 (40%), Positives = 123/198 (62%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +H+ G EVAVK I +L++ L EV I++ + HPNI+ L + I Sbjct: 60 GKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVI 119 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL++EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 120 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAE 179 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 180 NLLLDADMN---IKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 236 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 237 GVILYTLVSGSLPFDGQN 254
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 158 bits (399), Expect = 1e-38 Identities = 82/198 (41%), Positives = 122/198 (61%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +HV G EVAVK I +L+ L EV I++ + HPNI+ L + I Sbjct: 67 GKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI 126 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL++EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 127 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAE 186 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 187 NLLLDADMN---IKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 243 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 244 GVILYTLVSGSLPFDGQN 261
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 158 bits (399), Expect = 1e-38 Identities = 82/198 (41%), Positives = 122/198 (61%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +HV G EVAVK I +L+ L EV I++ + HPNI+ L + I Sbjct: 67 GKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI 126 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL++EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 127 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAE 186 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 187 NLLLDADMN---IKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 243 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 244 GVILYTLVSGSLPFDGQN 261
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 158 bits (399), Expect = 1e-38 Identities = 81/198 (40%), Positives = 123/198 (62%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +H+ G EVAVK I +L++ L EV I++ + HPNI+ L + I Sbjct: 60 GKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVI 119 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL++EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 120 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAE 179 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KIADFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 180 NLLLDADMN---IKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 236 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 237 GVILYTLVSGSLPFDGQN 254
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 157 bits (397), Expect = 2e-38 Identities = 80/198 (40%), Positives = 121/198 (61%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +H+ G EVA+K I +L+ L EV I++ + HPNI+ L + I Sbjct: 63 GKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI 122 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YLI+EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 123 ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAE 182 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KI DFGF+ +T CGSP Y APE+ Q +KYD + D+WS+ Sbjct: 183 NLLLDADMN---IKITDFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 239 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 240 GVILYTLVSGSLPFDGQN 257
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 154 bits (389), Expect = 2e-37 Identities = 80/198 (40%), Positives = 122/198 (61%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +H+ G EVAVK I +L++ L EV I++ + HPNI+ L + I Sbjct: 60 GKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVI 119 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL++EY GG+++ YL+ H R+ E A+ RQ+ +Q + +VHRDLK + Sbjct: 120 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVLHVQYCHQKFIVHRDLKAE 179 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL ++ +KIADFGF+ +T CGSP Y APE+ Q +K D + D+WS+ Sbjct: 180 NLLLDADMN---IKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKIDGPEVDVWSL 236 Query: 551 GIILYQLVTGSPPFNGDS 604 G+ILY LV+GS PF+G + Sbjct: 237 GVILYTLVSGSLPFDGQN 254
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 154 bits (388), Expect = 2e-37 Identities = 76/197 (38%), Positives = 118/197 (59%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V+LG++ A+K I L +L EVDIL+++ HPNIIAL + Sbjct: 15 GRGAFSIVYLGENKQTKQRYAIKVINKSELGKDYEKNLKMEVDILKKVNHPNIIALKELF 74 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 ++YL++E GG+L+ ++ E A + ++++ + L N+VHRDLKP+ Sbjct: 75 DTPEKLYLVMELVTGGELFDKIVEKGSYSEADAANLVKKIVSAVGYLHGLNIVHRDLKPE 134 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N+LL S + IADFG +K + + + +T CG+P Y+APEV+ A YD + D+WS+G Sbjct: 135 NLLLKSKENHLEVAIADFGLSKIIGQTLVMQTACGTPSYVAPEVLNATGYDKEVDMWSIG 194 Query: 554 IILYQLVTGSPPFNGDS 604 +I Y L+ G PPF GD+ Sbjct: 195 VITYILLCGFPPFYGDT 211
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 151 bits (382), Expect = 1e-36 Identities = 78/198 (39%), Positives = 118/198 (59%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G V LG H G +VA+K + ++LS + + E+ IL+ I HP+++ LHD Sbjct: 57 GKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVY 116 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + +YL+LE+ GG+L+ YL++ R+ A+ F RQ+ L ++ HRDLKP+ Sbjct: 117 ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPE 176 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL N ++IADFG A L ET CGSP Y PEV++ +KYD +AD+WS Sbjct: 177 NLLLDEKNN---IRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSC 233 Query: 551 GIILYQLVTGSPPFNGDS 604 G+IL+ L+ G+ PF+ D+ Sbjct: 234 GVILFALLVGALPFDDDN 251
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 150 bits (380), Expect = 2e-36 Identities = 73/197 (37%), Positives = 121/197 (61%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++S ++G ++ G V VKE+ ++ ++ +E+++LR++ H II L + Sbjct: 118 GKGSFSTAYIGTNILYGNRVVVKEVDKSKVK---ESNVYTEIEVLRKVMHKYIIKLISAY 174 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 G +YL+LEY +GG+L+ YL + E VAK ++++ L+ L + VVHRDLK + Sbjct: 175 EQEGFVYLVLEYLKGGELFEYLNNNGPYTEQVAKKAMKRVLIALEALHSNGVVHRDLKME 234 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N++L + N S LKI DFG A FL + CGSP Y+APE+++ Y K D++S+G Sbjct: 235 NLMLENPNDPSSLKIIDFGLASFLNSPSM-NMRCGSPGYVAPEILKCASYGTKVDIFSLG 293 Query: 554 IILYQLVTGSPPFNGDS 604 +IL+ ++ G PPF G++ Sbjct: 294 VILFNILCGYPPFRGNN 310
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 150 bits (379), Expect = 3e-36 Identities = 78/196 (39%), Positives = 117/196 (59%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G ++ V LG+H TEVA+K I +L A + + EV I++ + HP+II L+ + Sbjct: 27 GKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVM 86 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL+ EY + G+++ YL H R+ E+ A+ Q+ + VVHRDLK + Sbjct: 87 ETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLKAE 146 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL +N +KIADFGF F + L T CGSP Y APEV + Q+Y+ + D+WS+ Sbjct: 147 NLLLDNNMN---IKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSM 203 Query: 551 GIILYQLVTGSPPFNG 598 G++LY LV G+ PF+G Sbjct: 204 GVVLYVLVCGALPFDG 219
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 149 bits (377), Expect = 5e-36 Identities = 77/196 (39%), Positives = 117/196 (59%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G ++ V LG+H TEVA+K I +L A + + EV I++ + HP+II L+ + Sbjct: 27 GKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVM 86 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL+ EY + G+++ YL H R+ E+ A+ Q+ + +VHRDLK + Sbjct: 87 ETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAE 146 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL +N +KIADFGF F + L T CGSP Y APEV + Q+Y+ + D+WS+ Sbjct: 147 NLLLDNNMN---IKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSM 203 Query: 551 GIILYQLVTGSPPFNG 598 G++LY LV G+ PF+G Sbjct: 204 GVVLYVLVCGALPFDG 219
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 149 bits (376), Expect = 6e-36 Identities = 78/198 (39%), Positives = 117/198 (59%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G V LG H +VA+K + ++LS + + E+ IL+ I HP+++ LHD Sbjct: 26 GKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVY 85 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + +YL+LE+ GG+L+ YL++ R+ A+ F RQ+ L ++ HRDLKP+ Sbjct: 86 ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 145 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL N ++IADFG A L ET CGSP Y PEV++ +KYD KAD+WS Sbjct: 146 NLLLDEKNN---IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSC 202 Query: 551 GIILYQLVTGSPPFNGDS 604 G+IL+ L+ G+ PF+ D+ Sbjct: 203 GVILFALLVGALPFDDDN 220
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 149 bits (376), Expect = 6e-36 Identities = 77/195 (39%), Positives = 117/195 (60%), Gaps = 2/195 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G ++ V L +HV G +VAVK I +L L EV ++ + HPNI+ L++ I Sbjct: 23 GRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVI 82 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKR-VPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++YLILE GGD++ Y+++H+ + E +AK + Q+ + + +VVHRDLKP Sbjct: 83 DTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA-DLWS 547 +N++ G ++K+ DFGF+ QP T CGS Y APE++ +YDA A D+WS Sbjct: 143 ENVVFFEKQG--LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWS 200 Query: 548 VGIILYQLVTGSPPF 592 +G+IL+ LV G PPF Sbjct: 201 LGVILFMLVCGQPPF 215
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 149 bits (376), Expect = 6e-36 Identities = 77/195 (39%), Positives = 117/195 (60%), Gaps = 2/195 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G ++ V L +HV G +VAVK I +L L EV ++ + HPNI+ L++ I Sbjct: 23 GRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVI 82 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKR-VPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++YLILE GGD++ Y+++H+ + E +AK + Q+ + + +VVHRDLKP Sbjct: 83 DTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA-DLWS 547 +N++ G ++K+ DFGF+ QP T CGS Y APE++ +YDA A D+WS Sbjct: 143 ENVVFFEKQG--LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWS 200 Query: 548 VGIILYQLVTGSPPF 592 +G+IL+ LV G PPF Sbjct: 201 LGVILFMLVCGQPPF 215
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 149 bits (376), Expect = 6e-36 Identities = 77/195 (39%), Positives = 117/195 (60%), Gaps = 2/195 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G ++ V L +HV G +VAVK I +L L EV ++ + HPNI+ L++ I Sbjct: 23 GRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVI 82 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKR-VPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++YLILE GGD++ Y+++H+ + E +AK + Q+ + + +VVHRDLKP Sbjct: 83 DTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA-DLWS 547 +N++ G ++K+ DFGF+ QP T CGS Y APE++ +YDA A D+WS Sbjct: 143 ENVVFFEKQG--LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWS 200 Query: 548 VGIILYQLVTGSPPF 592 +G+IL+ LV G PPF Sbjct: 201 LGVILFMLVCGQPPF 215
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 148 bits (374), Expect = 1e-35 Identities = 82/221 (37%), Positives = 123/221 (55%), Gaps = 24/221 (10%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G +++V L +H+ G EVA+K I +L+ L EV I++ + HPNI+ L + I Sbjct: 63 GKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI 122 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQ--------------------- 310 +YLI+EY GG+++ YL+ H R+ E A+ RQ Sbjct: 123 ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMF 182 Query: 311 --LACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSP 484 + +Q + +VHRDLK +N+LL ++ +KIADFGF+ G +T CGSP Sbjct: 183 TFIVSAVQYCHQKRIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGGKLDTFCGSP 239 Query: 485 LYMAPEVMQAQKYDA-KADLWSVGIILYQLVTGSPPFNGDS 604 Y APE+ Q +KYD + D+WS+G+ILY LV+GS PF+G + Sbjct: 240 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 280
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 147 bits (371), Expect = 2e-35 Identities = 71/206 (34%), Positives = 125/206 (60%), Gaps = 10/206 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR-------DSLLSEVDILRRITHPNI 172 GSGAY V L + A+K + + LS D +L+E I++ ++HP + Sbjct: 181 GSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCV 240 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 + +HD + +Y++LE+ RGGDL ++ +K + E ++K + Q+ ++ L + + Sbjct: 241 VRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGIT 300 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVM---QAQKY 523 HRDLKP N+LL +N+ ++LK++DFG +KF+Q + TLCG+PLY+APEV+ + Y Sbjct: 301 HRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAY 360 Query: 524 DAKADLWSVGIILYQLVTGSPPFNGD 601 K D+WS+G++L+ ++G+ PF+ + Sbjct: 361 TKKVDIWSLGVVLFTCLSGTLPFSDE 386
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 145 bits (367), Expect = 7e-35 Identities = 76/197 (38%), Positives = 113/197 (57%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G Y V+ G A+KE DRL K + E++I++++ HPNI+ L+++ Sbjct: 78 GQGTYGCVYKGIDKVTNQLYAIKEEKKDRL--KNINRFFQEIEIMKKLDHPNIVKLYETY 135 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + IYLI+E C G +L+ ++ + E A ++Q+ + L N+VHRDLKP+ Sbjct: 136 ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPE 195 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N L S N S+LKI DFG +K L T G+P Y+AP+V+ KYD K D+WS G Sbjct: 196 NFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDIWSSG 254 Query: 554 IILYQLVTGSPPFNGDS 604 +I+Y L+ G PPF GD+ Sbjct: 255 VIMYTLLCGYPPFYGDT 271
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 145 bits (367), Expect = 7e-35 Identities = 75/200 (37%), Positives = 125/200 (62%), Gaps = 6/200 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL--SAKLRDSLLSEVDILRRITHPNIIALHD 187 G GA+++V+ + G VAVK + +L + L +++ E+ I+RR++HPNI+ LH+ Sbjct: 28 GCGAFAKVFHARDRRTGQSVAVKILNKKKLLTNPALANNIKREISIMRRLSHPNIVKLHE 87 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 + +I+ +E+ +GG+L+ + +H R+ E +++ + +QL + V HRDLK Sbjct: 88 VMATKSKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQLISAVGYCHARGVYHRDLK 147 Query: 368 PQNILLVSNNGTSILKIADFGFAKF---LQPSGLAETLCGSPLYMAPEVMQAQKYD-AKA 535 P+N LL+ NG LK++DFG + ++P GL TLCG+P Y+APE++ + Y+ AK Sbjct: 148 PEN-LLIDENGN--LKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILSKKGYEGAKV 204 Query: 536 DLWSVGIILYQLVTGSPPFN 595 D+WS GI+L+ LV G PFN Sbjct: 205 DVWSCGIVLFVLVAGYLPFN 224
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 145 bits (367), Expect = 7e-35 Identities = 76/197 (38%), Positives = 113/197 (57%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G Y V+ G A+KE DRL K + E++I++++ HPNI+ L+++ Sbjct: 78 GQGTYGCVYKGIDKVTNQLYAIKEEKKDRL--KNINRFFQEIEIMKKLDHPNIVKLYETY 135 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + IYLI+E C G +L+ ++ + E A ++Q+ + L N+VHRDLKP+ Sbjct: 136 ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPE 195 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N L S N S+LKI DFG +K L T G+P Y+AP+V+ KYD K D+WS G Sbjct: 196 NFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDIWSSG 254 Query: 554 IILYQLVTGSPPFNGDS 604 +I+Y L+ G PPF GD+ Sbjct: 255 VIMYTLLCGYPPFYGDT 271
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 144 bits (362), Expect = 3e-34 Identities = 75/193 (38%), Positives = 113/193 (58%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+GA+S+V L + VA+K IA + L K S+ +E+ +L +I HPNI+AL D Sbjct: 27 GTGAFSEVILAEDKRTQKLVAIKCIAKEALEGK-EGSMENEIAVLHKIKHPNIVALDDIY 85 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 GG +YLI++ GG+L+ ++ E A I Q+ ++ L + +VHRDLKP+ Sbjct: 86 ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPE 145 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N+L S + S + I+DFG +K P + T CG+P Y+APEV+ + Y D WS+G Sbjct: 146 NLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 205 Query: 554 IILYQLVTGSPPF 592 +I Y L+ G PPF Sbjct: 206 VIAYILLCGYPPF 218
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 142 bits (359), Expect = 6e-34 Identities = 75/193 (38%), Positives = 112/193 (58%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+GA+S+V L + VA+K IA L K S+ +E+ +L +I HPNI+AL D Sbjct: 27 GTGAFSEVILAEDKRTQKLVAIKCIAKKALEGK-EGSMENEIAVLHKIKHPNIVALDDIY 85 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 GG +YLI++ GG+L+ ++ E A I Q+ ++ L + +VHRDLKP+ Sbjct: 86 ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPE 145 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N+L S + S + I+DFG +K P + T CG+P Y+APEV+ + Y D WS+G Sbjct: 146 NLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 205 Query: 554 IILYQLVTGSPPF 592 +I Y L+ G PPF Sbjct: 206 VIAYILLCGYPPF 218
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 142 bits (359), Expect = 6e-34 Identities = 75/193 (38%), Positives = 112/193 (58%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+GA+S+V L + VA+K IA L K S+ +E+ +L +I HPNI+AL D Sbjct: 27 GTGAFSEVILAEDKRTQKLVAIKCIAKKALEGK-EGSMENEIAVLHKIKHPNIVALDDIY 85 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 GG +YLI++ GG+L+ ++ E A I Q+ ++ L + +VHRDLKP+ Sbjct: 86 ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPE 145 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N+L S + S + I+DFG +K P + T CG+P Y+APEV+ + Y D WS+G Sbjct: 146 NLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 205 Query: 554 IILYQLVTGSPPF 592 +I Y L+ G PPF Sbjct: 206 VIAYILLCGYPPF 218
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 142 bits (359), Expect = 6e-34 Identities = 75/196 (38%), Positives = 115/196 (58%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G ++ V LG+H TEVA+K I +L A + + EV I++ + HP+II L+ + Sbjct: 27 GKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVM 86 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL+ EY + G+++ YL H R+ E+ A+ Q+ + +VHRDLK + Sbjct: 87 ETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAE 146 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADLWSV 550 N+LL +N +KIADF F F + L T GSP Y APEV + Q+Y+ + D+WS+ Sbjct: 147 NLLLDNNMN---IKIADFSFGNFFKSGELLATWRGSPPYAAPEVFEGQQYEGPQLDIWSM 203 Query: 551 GIILYQLVTGSPPFNG 598 G++LY LV G+ PF+G Sbjct: 204 GVVLYVLVCGALPFDG 219
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 142 bits (359), Expect = 6e-34 Identities = 77/199 (38%), Positives = 117/199 (58%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKL-RDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L K G E A+K I+ + K + SLL EV++L+ + H NI+ L++ Sbjct: 76 GKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEF 135 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D YL+ + GG+L+ ++ KR E A I+Q+ G+ + ++NVVHRDLKP Sbjct: 136 FEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRDLKP 195 Query: 371 QNILL-VSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +NILL N I+KI DFG + + S + G+ Y+AP+V+ YD K D+WS Sbjct: 196 ENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG-TYDEKCDIWS 254 Query: 548 VGIILYQLVTGSPPFNGDS 604 G+ILY L++G PPFNG + Sbjct: 255 CGVILYILLSGCPPFNGSN 273
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 142 bits (359), Expect = 6e-34 Identities = 77/199 (38%), Positives = 117/199 (58%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKL-RDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L K G E A+K I+ + K + SLL EV++L+ + H NI+ L++ Sbjct: 76 GKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEF 135 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D YL+ + GG+L+ ++ KR E A I+Q+ G+ + ++NVVHRDLKP Sbjct: 136 FEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRDLKP 195 Query: 371 QNILL-VSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +NILL N I+KI DFG + + S + G+ Y+AP+V+ YD K D+WS Sbjct: 196 ENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG-TYDEKCDIWS 254 Query: 548 VGIILYQLVTGSPPFNGDS 604 G+ILY L++G PPFNG + Sbjct: 255 CGVILYILLSGCPPFNGSN 273
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 142 bits (358), Expect = 8e-34 Identities = 71/199 (35%), Positives = 117/199 (58%), Gaps = 1/199 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G ++ V L +H T+VA+K I RL + + + EV +++ + HPNII L+ Sbjct: 31 RTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLY 90 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + +Y++ E+ + G+++ YL + + E A+ Q+ ++ ++VHRDL Sbjct: 91 QVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDL 150 Query: 365 KPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADL 541 K +N+LL +G +K+ADFGF F +P T CGSP Y APEV + ++Y+ + D+ Sbjct: 151 KTENLLL---DGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDI 207 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G++LY LV GS PF+G Sbjct: 208 WSLGVVLYVLVCGSLPFDG 226
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 142 bits (358), Expect = 8e-34 Identities = 76/199 (38%), Positives = 118/199 (59%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKL-RDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L + G E A+K I+ + K ++SLL EV++L+ + H NI+ L++ Sbjct: 76 GKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEF 135 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D YL+ + GG+L+ ++ KR E A I+Q+ G+ + ++NVVHRDLKP Sbjct: 136 FEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKP 195 Query: 371 QNILL-VSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +NILL N I+KI DFG + + S + G+ Y+AP+V+ YD K D+WS Sbjct: 196 ENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG-TYDEKCDIWS 254 Query: 548 VGIILYQLVTGSPPFNGDS 604 G+ILY L++G PPFNG + Sbjct: 255 CGVILYILLSGCPPFNGSN 273
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 142 bits (357), Expect = 1e-33 Identities = 73/197 (37%), Positives = 113/197 (57%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 GSG + V+ GKH G +VA+K I R K L +EV IL+ + HP I+ L Sbjct: 583 GSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMF 642 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHK-RVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 R+++++E G L L K R+PE + K + Q+ L+ L N+VH DLKP Sbjct: 643 ETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 702 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL S +K+ DFGFA+ + ++ G+P Y+APEV++++ Y+ D+WSV Sbjct: 703 ENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSV 762 Query: 551 GIILYQLVTGSPPFNGD 601 G+I+Y ++G+ PFN D Sbjct: 763 GVIIYVSLSGTFPFNED 779
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 141 bits (356), Expect = 1e-33 Identities = 73/197 (37%), Positives = 113/197 (57%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 GSG + V+ GKH G +VA+K I R K L +EV IL+ + HP I+ L Sbjct: 582 GSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMF 641 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHK-RVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 R+++++E G L L K R+PE + K + Q+ L+ L N+VH DLKP Sbjct: 642 ETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 701 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL S +K+ DFGFA+ + ++ G+P Y+APEV++++ Y+ D+WSV Sbjct: 702 ENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSV 761 Query: 551 GIILYQLVTGSPPFNGD 601 G+I+Y ++G+ PFN D Sbjct: 762 GVIVYVSLSGTFPFNED 778
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 140 bits (354), Expect = 2e-33 Identities = 65/198 (32%), Positives = 118/198 (59%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V+ +H+ G A+K + D + + EV+I + HPN+ L+ Sbjct: 116 GKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPNLTQLYGY 175 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YL++EY G+LY +L + VA +++ Q+A L + E N++HRD+KP Sbjct: 176 FHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHERNILHRDIKP 235 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NI++ NN +K+ DFG++ +TLCG+ Y++PE++++++Y+ K D+W++ Sbjct: 236 ENIIIGFNN---TIKLTDFGWSVITPKGSKRKTLCGTVDYLSPELIRSREYNEKVDVWAL 292 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+L+ GSPPF +S Sbjct: 293 GVLTYELLVGSPPFEEES 310
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 140 bits (353), Expect = 3e-33 Identities = 73/202 (36%), Positives = 123/202 (60%), Gaps = 2/202 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 R G G++ +V + +H G +VA+K + ++ + ++ + + E+ ILR HP+II L Sbjct: 46 RTLGIGSFGRVKIAEHALTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRL 105 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 ++ I IYL++EY G+L+ Y++ R+ E A++F +Q+ G++ + VVHRD Sbjct: 106 YEVIETPTDIYLVMEYVNSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRD 165 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKAD 538 LKP+N+LL S +KIADFG + ++ +T CGSP Y APEV+ + Y + D Sbjct: 166 LKPENLLLDSKCN---VKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVD 222 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS G+ILY L+ G+ PF+ ++ Sbjct: 223 VWSCGVILYALLCGTLPFDDEN 244
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 140 bits (352), Expect = 4e-33 Identities = 71/199 (35%), Positives = 123/199 (61%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V + +HV G +VA+K + ++ + ++ + + E+ ILR HP+II ++ Sbjct: 27 GIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQYEV 86 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I IY+++EY + G+L+ Y++ R+ E A++F +Q+ G++ + VVHRDLKP Sbjct: 87 IETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKP 146 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL S +KIADFG + ++ +T CGSP Y APEV+ + Y + D+WS Sbjct: 147 ENLLLDSRCN---IKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWS 203 Query: 548 VGIILYQLVTGSPPFNGDS 604 G+ILY L+ G+ PF+ ++ Sbjct: 204 CGVILYALLCGTLPFDDEN 222
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)| Length = 878 Score = 140 bits (352), Expect = 4e-33 Identities = 75/197 (38%), Positives = 112/197 (56%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 GSG + V+ GKH G +VAVK I R K L +EV IL+ + HP I+ L Sbjct: 558 GSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMF 617 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHK-RVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++++++E G L L K R+PE + K I Q+ L+ L N+VH DLKP Sbjct: 618 ETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKP 677 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL S + +K+ DFGFA+ + ++ G+P Y+APEV+ Q Y+ D+WSV Sbjct: 678 ENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSV 737 Query: 551 GIILYQLVTGSPPFNGD 601 G+I+Y ++G+ PFN D Sbjct: 738 GVIMYVSLSGTFPFNED 754
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 139 bits (351), Expect = 5e-33 Identities = 73/197 (37%), Positives = 113/197 (57%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 GSG + V+ GKH G +VA+K I R K L +EV IL+ + HP ++ L Sbjct: 590 GSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMF 649 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHK-RVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 R+++++E G L L K R+PE + K I Q+ L+ L N+VH DLKP Sbjct: 650 ETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKP 709 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL S + +K+ DFGFA+ + ++ G+P Y+APEV++ + Y+ D+WSV Sbjct: 710 ENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSV 769 Query: 551 GIILYQLVTGSPPFNGD 601 G+I+Y ++G+ PFN D Sbjct: 770 GVIIYVSLSGTFPFNED 786
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 139 bits (351), Expect = 5e-33 Identities = 74/194 (38%), Positives = 117/194 (60%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V+L K G VA+K + L +K+ + E++I + H NI+ L+ Sbjct: 96 GKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGH 155 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D RIYLILE+ G+LY +L R KR E VA +I Q+A L L + +V+HRD+KP Sbjct: 156 FHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKP 215 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NILL + +K++DFG++ PS TLCG+ Y+ PE+++ +++ K DLWS+ Sbjct: 216 ENILLGIDGE---IKLSDFGWSVH-APSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSL 271 Query: 551 GIILYQLVTGSPPF 592 G++ Y+ + G+PPF Sbjct: 272 GVLTYEFLVGAPPF 285
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 139 bits (351), Expect = 5e-33 Identities = 73/208 (35%), Positives = 114/208 (54%), Gaps = 11/208 (5%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA-----------KLRDSLLSEVDILRRIT 160 GSGAY +V L K +E A+K I + K + + +E+ +L+ + Sbjct: 63 GSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFHEEIYNEISLLKSLD 122 Query: 161 HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRE 340 HPNII L D D YL+ E+ GG+L+ ++ + E A + ++Q+ G+ L + Sbjct: 123 HPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHK 182 Query: 341 SNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQK 520 N+VHRD+KP+NILL + N +KI DFG + F G+ Y+APEV++ +K Sbjct: 183 HNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLK-KK 241 Query: 521 YDAKADLWSVGIILYQLVTGSPPFNGDS 604 Y+ K D+WS G+I+Y L+ G PPF G + Sbjct: 242 YNEKCDVWSCGVIMYILLCGYPPFGGQN 269
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 139 bits (350), Expect = 6e-33 Identities = 71/199 (35%), Positives = 116/199 (58%), Gaps = 1/199 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G ++ V L +H T+VA+K I RL + + + EV +++ + HPNII L+ Sbjct: 31 RTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLY 90 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + +Y++ E+ + G+++ YL + + E A+ Q+ ++ ++VHRDL Sbjct: 91 QVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDL 150 Query: 365 KPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADL 541 K +N+LL SN +K+ADFGF F +P T GSP Y APEV + ++Y+ + D+ Sbjct: 151 KTENLLLDSNMD---IKLADFGFGNFYKPGEPLSTCVGSPPYAAPEVFEGKEYEGPQLDV 207 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G++LY LV GS PF+G Sbjct: 208 WSLGVVLYVLVCGSLPFDG 226
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 138 bits (348), Expect = 1e-32 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 2/197 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKL-RDSLLSEVDILRRITHPNIIALHDS 190 G G Y +V G VA+K I D++ +L + E++I+ + HP+II++++ Sbjct: 63 GKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEV 122 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +I +I+EY G+LY Y+ +R+ E +HF RQ+ + ++ VVHRDLK Sbjct: 123 FENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKL 182 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +NILL N +KIADFG + Q +T CGSPLY +PE++ + Y + D W+ Sbjct: 183 ENILLDDNCN---IKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWA 239 Query: 548 VGIILYQLVTGSPPFNG 598 +G++LY L+ G+ PF+G Sbjct: 240 LGVLLYTLIYGTMPFDG 256
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 138 bits (347), Expect = 1e-32 Identities = 69/199 (34%), Positives = 117/199 (58%), Gaps = 1/199 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G ++ V L +H T+VA+K I RL + + + EV +++ + HP+II L+ Sbjct: 31 RTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLY 90 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + +Y++ E+ + G+++ YL + + E A+ Q+ ++ + ++VHRDL Sbjct: 91 QVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDL 150 Query: 365 KPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADL 541 K +N+LL +G +K+ADFGF F + T CGSP Y APEV + ++Y+ + D+ Sbjct: 151 KTENLLL---DGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDI 207 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G++LY LV GS PF+G Sbjct: 208 WSLGVVLYVLVCGSLPFDG 226
>KAPC_ASCSU (P49673) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 337 Score = 137 bits (346), Expect = 2e-32 Identities = 68/196 (34%), Positives = 123/196 (62%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V+L +H A A+K++A+ + +S + + + SE +L R++HP I+ ++ + Sbjct: 36 GTGSFGRVYLVQHRASEQYFALKKMAIREVVSMRQTEHVHSEKRLLSRLSHPFIVKMYCA 95 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D +Y++ EY GG+L++YL + ++A+ + ++ C LQ L N+ +RDLKP Sbjct: 96 SWDKYNLYMLFEYLAGGELFSYLRASRTFSNSMARFYAAEIVCALQYLHSKNIAYRDLKP 155 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N++L N LK+ DFGFAK + T+CG+P Y+APEV+ + +D D WS+ Sbjct: 156 ENLML---NKEGHLKMTDFGFAK--EVIDRTWTMCGTPEYLAPEVIGNKGHDTAVDWWSL 210 Query: 551 GIILYQLVTGSPPFNG 598 G+++Y+++ G PPF G Sbjct: 211 GVLIYEMMIGIPPFRG 226
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 137 bits (345), Expect = 2e-32 Identities = 72/201 (35%), Positives = 117/201 (58%), Gaps = 4/201 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G+Y +V L KH G + +K++ + S++ R + E +L ++ HPNI+ Sbjct: 10 RVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYK 69 Query: 185 DSIRDG-GRIYLILEYCRGGDLYAYLLRHKR--VPETVAKHFIRQLACGLQKLRESNVVH 355 +S G G +Y+++ +C GGDLY L K +PE+ + Q+A LQ L E +++H Sbjct: 70 ESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILH 129 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQPSG-LAETLCGSPLYMAPEVMQAQKYDAK 532 RDLK QN+ L N I+K+ D G A+ L+ G +A TL G+P YM+PE+ + Y+ K Sbjct: 130 RDLKTQNVFLTRTN---IIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYK 186 Query: 533 ADLWSVGIILYQLVTGSPPFN 595 +D+W++G +Y++ T FN Sbjct: 187 SDVWALGCCVYEMATLKHAFN 207
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 137 bits (345), Expect = 2e-32 Identities = 72/210 (34%), Positives = 114/210 (54%), Gaps = 13/210 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA-------------KLRDSLLSEVDILRR 154 GSGAY +V L + E A+K I + K+ + + +E+ +L+ Sbjct: 62 GSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKS 121 Query: 155 ITHPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKL 334 + HPNII L D D YL+ E+ GG+L+ ++ + E A + ++Q+ G+ L Sbjct: 122 LDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYL 181 Query: 335 RESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQA 514 + N+VHRD+KP+NILL + + +KI DFG + F G+ Y+APEV++ Sbjct: 182 HKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLR- 240 Query: 515 QKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 +KY+ K D+WS G+ILY L+ G PPF G + Sbjct: 241 KKYNEKCDVWSCGVILYILLCGYPPFGGQN 270
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 137 bits (345), Expect = 2e-32 Identities = 72/210 (34%), Positives = 114/210 (54%), Gaps = 13/210 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA-------------KLRDSLLSEVDILRR 154 GSGAY +V L + E A+K I + K+ + + +E+ +L+ Sbjct: 62 GSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKS 121 Query: 155 ITHPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKL 334 + HPNII L D D YL+ E+ GG+L+ ++ + E A + ++Q+ G+ L Sbjct: 122 LDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYL 181 Query: 335 RESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQA 514 + N+VHRD+KP+NILL + + +KI DFG + F G+ Y+APEV++ Sbjct: 182 HKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLR- 240 Query: 515 QKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 +KY+ K D+WS G+ILY L+ G PPF G + Sbjct: 241 KKYNEKCDVWSCGVILYILLCGYPPFGGQN 270
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 137 bits (344), Expect = 3e-32 Identities = 72/197 (36%), Positives = 112/197 (56%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 GSG + V+ GKH G +VA+K I R K L +EV IL+ + HP ++ L Sbjct: 596 GSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMF 655 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKR-VPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 R+++++E G L L K +PE + K I Q+ L+ L N+VH DLKP Sbjct: 656 ETPERVFVVMEKLHGDMLEMILSSEKGWLPEHITKFLITQILVALRHLHFKNIVHCDLKP 715 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL S + +K+ DFGFA+ + ++ G+P Y+APEV++ + Y+ D+WSV Sbjct: 716 ENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSV 775 Query: 551 GIILYQLVTGSPPFNGD 601 G+I+Y ++G+ PFN D Sbjct: 776 GVIIYVSLSGTFPFNED 792
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 136 bits (343), Expect = 4e-32 Identities = 70/197 (35%), Positives = 113/197 (57%), Gaps = 2/197 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKL-RDSLLSEVDILRRITHPNIIALHDS 190 G G Y +V G VA+K I D++ + + E++I+ + HP+II++++ Sbjct: 62 GKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEV 121 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +I +I+EY G+LY Y+ +R+ E +HF RQ+ + ++ VVHRDLK Sbjct: 122 FENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKL 181 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +NILL N +KIADFG + Q +T CGSPLY +PE++ + Y + D W+ Sbjct: 182 ENILLDDNCN---IKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWA 238 Query: 548 VGIILYQLVTGSPPFNG 598 +G++LY LV G+ PF+G Sbjct: 239 LGVLLYTLVYGTMPFDG 255
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 136 bits (343), Expect = 4e-32 Identities = 74/203 (36%), Positives = 119/203 (58%), Gaps = 9/203 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS------AKLRDSLLSEVDILRRITHPNII 175 GSGA +V + +VA+K I+ R + A S+ +E++IL+++ HP II Sbjct: 231 GSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCII 290 Query: 176 ALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVH 355 + D + D Y++LE GG+L+ ++ +KR+ E K + Q+ +Q L E+ ++H Sbjct: 291 KIKD-VFDAEDYYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIH 349 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQ---KYD 526 RDLKP+N+LL S ++KI DFG +K L + L TLCG+P Y+APEV+ + Y Sbjct: 350 RDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYS 409 Query: 527 AKADLWSVGIILYQLVTGSPPFN 595 D WS+G+IL+ ++G PPF+ Sbjct: 410 RAVDCWSLGVILFICLSGYPPFS 432
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 136 bits (343), Expect = 4e-32 Identities = 73/193 (37%), Positives = 108/193 (55%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+GA+S+V L + A G AVK I L K S+ +E+ +LR+I H NI+AL D Sbjct: 30 GTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESSIENEIAVLRKIKHENIVALEDIY 88 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL+++ GG+L+ ++ E A IRQ+ + L +VHRDLKP+ Sbjct: 89 ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPE 148 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N+L S + S + I+DFG +K + T CG+P Y+APEV+ + Y D WS+G Sbjct: 149 NLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 208 Query: 554 IILYQLVTGSPPF 592 +I Y L+ G PPF Sbjct: 209 VIAYILLCGYPPF 221
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 136 bits (343), Expect = 4e-32 Identities = 73/193 (37%), Positives = 108/193 (55%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+GA+S+V L + A G AVK I L K S+ +E+ +LR+I H NI+AL D Sbjct: 30 GTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESSIENEIAVLRKIKHENIVALEDIY 88 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +YL+++ GG+L+ ++ E A IRQ+ + L +VHRDLKP+ Sbjct: 89 ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPE 148 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVG 553 N+L S + S + I+DFG +K + T CG+P Y+APEV+ + Y D WS+G Sbjct: 149 NLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 208 Query: 554 IILYQLVTGSPPF 592 +I Y L+ G PPF Sbjct: 209 VIAYILLCGYPPF 221
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 136 bits (342), Expect = 5e-32 Identities = 72/199 (36%), Positives = 120/199 (60%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V+ +H G A+K I + L L L EVDI + HPNII L+ Sbjct: 107 GKGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQLGMDHPNIIKLYAH 166 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YL++E+ G+LY L + + +A H+I Q+A L + + ++HRD+KP Sbjct: 167 FHDEKRVYLLMEHSINGELYKSLKNNGPFNDVLASHYIYQIADALHYMHKKRIIHRDVKP 226 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSG-LAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +N+L+ +N ++K+ADFG++ L P G +TLCG+ Y++PE++ ++YD + D+W+ Sbjct: 227 ENVLIGFDN---VVKLADFGWS-ILNPEGSKRKTLCGTIDYLSPEMITPREYDEQVDVWA 282 Query: 548 VGIILYQLVTGSPPFNGDS 604 +G++ Y+LV G PPF +S Sbjct: 283 LGVLAYELVVGVPPFEENS 301
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 135 bits (341), Expect = 7e-32 Identities = 75/194 (38%), Positives = 114/194 (58%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 GSGA+S+V+L K G A+K I + S RDS L +E+ +L+RI H NI+ L D Sbjct: 30 GSGAFSEVFLVKQRVTGKLFALKCI---KKSPAFRDSSLENEIAVLKRIKHENIVTLEDI 86 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 YL+++ GG+L+ +L E A I+Q+ ++ L E+ +VHRDLKP Sbjct: 87 YESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L ++ S + I DFG +K ++ +G+ T CG+P Y+APEV+ + Y D WS+ Sbjct: 147 ENLLYLTPEENSKIMITDFGLSK-MEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSI 205 Query: 551 GIILYQLVTGSPPF 592 G+I Y L+ G PPF Sbjct: 206 GVITYILLCGYPPF 219
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 135 bits (341), Expect = 7e-32 Identities = 74/197 (37%), Positives = 113/197 (57%), Gaps = 1/197 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 +A G G + +V+L K G A+K + L + EV+I + H N++ L Sbjct: 103 KALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTNVLRL 162 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 D R+YLILEY G+LY L KR E+ A +I Q++ L L N++HRD Sbjct: 163 FGHFHDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALLYLHGKNIIHRD 222 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 +KP+NILL N+ +KI+DFG++ PS TLCG+ Y+ PE++Q++ YD D+ Sbjct: 223 IKPENILLHFND---TIKISDFGWSVH-APSNRRSTLCGTMDYLPPEIVQSRPYDKNVDV 278 Query: 542 WSVGIILYQLVTGSPPF 592 WS+GI++Y+ + G+PPF Sbjct: 279 WSLGILMYEFLCGAPPF 295
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 135 bits (341), Expect = 7e-32 Identities = 66/198 (33%), Positives = 119/198 (60%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V+ KH G A+K + + ++ EV+I H N+ L+ Sbjct: 107 GKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGSFKHKNLTQLYGF 166 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YL++EY G+LY +L + + ET+A +F+ Q+A L + N++HRD+KP Sbjct: 167 FYDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVYQMANALDYMHSKNILHRDIKP 226 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NIL+ NN +K+ DFG++ + + +TLCG+ Y++PE++++++Y+ K D+W++ Sbjct: 227 ENILIGFNN---TIKLTDFGWSVYNEDGQKRKTLCGTIDYLSPELIKSREYNNKVDVWAL 283 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+L+ GSPPF D+ Sbjct: 284 GVLTYELLVGSPPFEEDT 301
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 135 bits (341), Expect = 7e-32 Identities = 74/198 (37%), Positives = 114/198 (57%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + V+L + +A+K + +L A + L EV+I + HPNI+ L+ Sbjct: 147 GKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGY 206 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YLIL+Y GG+L+ L + R + + +I+QLA L V+HRD+KP Sbjct: 207 FHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEALLYCHSKKVIHRDIKP 266 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL SN LKIADFG++ PS TLCG+ Y+ PE+++ + +D K DLWS+ Sbjct: 267 ENLLLGSNGE---LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSL 322 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+ + G PPF D+ Sbjct: 323 GVLCYEFLVGKPPFETDT 340
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 135 bits (341), Expect = 7e-32 Identities = 75/194 (38%), Positives = 114/194 (58%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 GSGA+S+V+L K G A+K I + S RDS L +E+ +L+RI H NI+ L D Sbjct: 30 GSGAFSEVFLVKQRVTGKLFALKCI---KKSPAFRDSSLENEIAVLKRIKHENIVTLEDI 86 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 YL+++ GG+L+ +L E A I+Q+ ++ L E+ +VHRDLKP Sbjct: 87 YESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L ++ S + I DFG +K ++ +G+ T CG+P Y+APEV+ + Y D WS+ Sbjct: 147 ENLLYLTPEENSKIMITDFGLSK-MEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSI 205 Query: 551 GIILYQLVTGSPPF 592 G+I Y L+ G PPF Sbjct: 206 GVITYILLCGYPPF 219
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 135 bits (340), Expect = 9e-32 Identities = 77/200 (38%), Positives = 117/200 (58%), Gaps = 7/200 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK----LRDSLLSEVDILRRITHPNIIAL 181 G G++++V G HV G +VA+K I D+ AK + +L E I + I HPNI L Sbjct: 69 GEGSFAKVREGLHVLTGEKVAIKVI--DKKRAKKDTYVTKNLRREGQIQQMIRHPNITQL 126 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 D + YL++E C GG+L + KR+ E+ A+ +IRQL ++ L + VVHRD Sbjct: 127 LDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRD 186 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAE---TLCGSPLYMAPEVMQAQKYDAK 532 LK +N+LL +N +K+ DFG + G ++ T CGSP Y APE++ +KY K Sbjct: 187 LKIENLLLDEDNN---IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPK 243 Query: 533 ADLWSVGIILYQLVTGSPPF 592 D+WS+G+ +Y ++TG+ PF Sbjct: 244 IDVWSIGVNMYAMLTGTLPF 263
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 135 bits (340), Expect = 9e-32 Identities = 77/200 (38%), Positives = 117/200 (58%), Gaps = 7/200 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK----LRDSLLSEVDILRRITHPNIIAL 181 G G++++V G HV G +VA+K I D+ AK + +L E I + I HPNI L Sbjct: 69 GEGSFAKVREGLHVLTGEKVAIKVI--DKKRAKKDTYVTKNLRREGQIQQMIRHPNITQL 126 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 D + YL++E C GG+L + KR+ E+ A+ +IRQL ++ L + VVHRD Sbjct: 127 LDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRD 186 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAE---TLCGSPLYMAPEVMQAQKYDAK 532 LK +N+LL +N +K+ DFG + G ++ T CGSP Y APE++ +KY K Sbjct: 187 LKIENLLLDEDNN---IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPK 243 Query: 533 ADLWSVGIILYQLVTGSPPF 592 D+WS+G+ +Y ++TG+ PF Sbjct: 244 IDVWSIGVNMYAMLTGTLPF 263
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 135 bits (339), Expect = 1e-31 Identities = 77/200 (38%), Positives = 116/200 (58%), Gaps = 7/200 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK----LRDSLLSEVDILRRITHPNIIAL 181 G G++++V G HV G +VA+K I D+ AK + +L E I + I HPNI L Sbjct: 69 GEGSFAKVREGLHVLTGEKVAIKVI--DKKRAKKDTYVTKNLRREGQIQQMIRHPNITQL 126 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 D + YL++E C GG+L + KR+ E A+ +IRQL ++ L + VVHRD Sbjct: 127 LDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRD 186 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAE---TLCGSPLYMAPEVMQAQKYDAK 532 LK +N+LL +N +K+ DFG + G ++ T CGSP Y APE++ +KY K Sbjct: 187 LKIENLLLDEDNN---IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPK 243 Query: 533 ADLWSVGIILYQLVTGSPPF 592 D+WS+G+ +Y ++TG+ PF Sbjct: 244 IDVWSIGVNMYAMLTGTLPF 263
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 134 bits (338), Expect = 2e-31 Identities = 77/196 (39%), Positives = 109/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V V G E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 20 GKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YLI + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET---LCGSPLYMAPEVMQAQKYDAKADLW 544 N+LL S + +K+ADFG A ++ G + G+P Y++PEV++ Y DLW Sbjct: 140 NLLLASKLKGAAVKLADFGLA--IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLW 197 Query: 545 SVGIILYQLVTGSPPF 592 + G+ILY L+ G PPF Sbjct: 198 ACGVILYILLVGYPPF 213
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 134 bits (338), Expect = 2e-31 Identities = 77/196 (39%), Positives = 109/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V V G E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 20 GKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YLI + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET---LCGSPLYMAPEVMQAQKYDAKADLW 544 N+LL S + +K+ADFG A ++ G + G+P Y++PEV++ Y DLW Sbjct: 140 NLLLASKLKGAAVKLADFGLA--IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLW 197 Query: 545 SVGIILYQLVTGSPPF 592 + G+ILY L+ G PPF Sbjct: 198 ACGVILYILLVGYPPF 213
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 134 bits (338), Expect = 2e-31 Identities = 77/196 (39%), Positives = 109/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V V G E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 20 GKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YLI + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET---LCGSPLYMAPEVMQAQKYDAKADLW 544 N+LL S + +K+ADFG A ++ G + G+P Y++PEV++ Y DLW Sbjct: 140 NLLLASKLKGAAVKLADFGLA--IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLW 197 Query: 545 SVGIILYQLVTGSPPF 592 + G+ILY L+ G PPF Sbjct: 198 ACGVILYILLVGYPPF 213
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 134 bits (338), Expect = 2e-31 Identities = 69/199 (34%), Positives = 115/199 (57%), Gaps = 1/199 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G ++ V L +H T+VA+K I RL + + EV I++ + HP+II L+ Sbjct: 30 RTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYREVQIMKLLNHPHIIKLY 89 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + +Y++ E+ + G+++ +L + + E+ A+ Q+ ++ ++VHRDL Sbjct: 90 QVMETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQILSAVEYCHSHHIVHRDL 149 Query: 365 KPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDA-KADL 541 K +N+LL +N +K+ADFGF F + T CGSP Y APEV + ++Y+ D+ Sbjct: 150 KTENLLLDANMN---IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLDI 206 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G++LY LV GS PF+G Sbjct: 207 WSLGVVLYVLVCGSLPFDG 225
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 134 bits (338), Expect = 2e-31 Identities = 71/201 (35%), Positives = 115/201 (57%), Gaps = 4/201 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G+Y +V L KH G + +K++ + S++ R + E +L ++ HPNI+ Sbjct: 10 RVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYK 69 Query: 185 DSIRDG-GRIYLILEYCRGGDLYAYLLRHKR--VPETVAKHFIRQLACGLQKLRESNVVH 355 +S G G +Y+++ +C GGDLY L K +PE + Q+A LQ L E +++H Sbjct: 70 ESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILH 129 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYDAK 532 RDLK QN+ L N I+K+ D G A+ L+ +A TL G+P YM+PE+ + Y+ K Sbjct: 130 RDLKTQNVFLTRTN---IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYK 186 Query: 533 ADLWSVGIILYQLVTGSPPFN 595 +D+W++G +Y++ T FN Sbjct: 187 SDVWALGCCVYEMATLKHAFN 207
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 134 bits (338), Expect = 2e-31 Identities = 74/194 (38%), Positives = 114/194 (58%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 GSGA+S+V+L K G A+K I + S RDS L +E+ +L++I H NI+ L D Sbjct: 30 GSGAFSEVFLVKQRLTGKLFALKCI---KKSPAFRDSSLENEIAVLKKIKHENIVTLEDI 86 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 YL+++ GG+L+ +L E A I+Q+ ++ L E+ +VHRDLKP Sbjct: 87 YESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L ++ S + I DFG +K ++ +G+ T CG+P Y+APEV+ + Y D WS+ Sbjct: 147 ENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSI 205 Query: 551 GIILYQLVTGSPPF 592 G+I Y L+ G PPF Sbjct: 206 GVITYILLCGYPPF 219
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 134 bits (338), Expect = 2e-31 Identities = 70/196 (35%), Positives = 114/196 (58%), Gaps = 2/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK-LRDSLLSEVDILRRITHPNIIALHDS 190 G GA+ V G H+ G +VA+K + R+ + +E+D L+++THP+I L Sbjct: 31 GKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFRV 90 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I+L++E GG+L++Y+ R +P ++ + +Q+ G+ +VHRDLKP Sbjct: 91 ISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNHMIVHRDLKP 150 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL +N +KIADFG + ++ L T CGSP Y APE++ + Y + DLWS Sbjct: 151 ENLLLDANKN---IKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWS 207 Query: 548 VGIILYQLVTGSPPFN 595 G+ILY ++ G+ PF+ Sbjct: 208 CGVILYAMLCGTLPFD 223
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 134 bits (337), Expect = 2e-31 Identities = 75/203 (36%), Positives = 120/203 (59%), Gaps = 9/203 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL---SAKLRDSLLS---EVDILRRITHPNII 175 GSGA +V L +VA+K I+ + SA+ D L+ E++IL+++ HP II Sbjct: 227 GSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCII 286 Query: 176 ALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVH 355 + + D Y++LE GG+L+ ++ +KR+ E K + Q+ +Q L E+ ++H Sbjct: 287 KIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIH 345 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQA---QKYD 526 RDLKP+N+LL S ++KI DFG +K L + L TLCG+P Y+APEV+ + Y+ Sbjct: 346 RDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYN 405 Query: 527 AKADLWSVGIILYQLVTGSPPFN 595 D WS+G+IL+ ++G PPF+ Sbjct: 406 RAVDCWSLGVILFICLSGYPPFS 428
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 134 bits (336), Expect = 3e-31 Identities = 70/196 (35%), Positives = 114/196 (58%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G +V+ KH G A+K +A D + KL + E++I + HP I L+ Sbjct: 155 GKGKLGKVYCVKHKTSGYIAALKVMAKKDLIDLKLEKNFRREIEIQSNLIHPKISRLYGF 214 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D +YLILEY G+LY +L +R + A H+I Q+A L L +++HRD+KP Sbjct: 215 FYDHKNVYLILEYSIHGELYHHLKVQRRFNDATASHYIYQVALALDYLHTKHIIHRDIKP 274 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAE--TLCGSPLYMAPEVMQAQKYDAKADLW 544 +NILL ++N +K++DFG++ PS + T+CG+ Y+ PE++++ ++D D+W Sbjct: 275 ENILLSTDN---CIKLSDFGWSVKSLPSSSTKRLTICGTLDYLPPEMIESNEHDYTVDIW 331 Query: 545 SVGIILYQLVTGSPPF 592 S+GI+ Y+ + G PPF Sbjct: 332 SLGILCYEFLVGKPPF 347
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 134 bits (336), Expect = 3e-31 Identities = 74/194 (38%), Positives = 109/194 (56%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V + G E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 21 GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I+Q+ + + +VHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + + +K+ADFG A +Q A G+P Y++PEV++ Y D+W+ Sbjct: 141 NLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 134 bits (336), Expect = 3e-31 Identities = 73/198 (36%), Positives = 113/198 (57%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + V+L + +A+K + +L A + L EV+I + HPNI+ L+ Sbjct: 147 GKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGY 206 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YLIL+Y GG+L+ L + R + + +I+QLA L V+HRD+KP Sbjct: 207 FHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEALLYCHSKKVIHRDIKP 266 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL SN LKIADFG++ PS TLCG+ Y+ PE+++ + +D DLWS+ Sbjct: 267 ENLLLGSNGE---LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRMHDETVDLWSL 322 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+ + G PPF D+ Sbjct: 323 GVLCYEFLVGKPPFETDT 340
>CDR2_SCHPO (P87050) Mitosis inducer protein kinase cdr2 (EC 2.7.11.1)| Length = 775 Score = 133 bits (335), Expect = 3e-31 Identities = 73/199 (36%), Positives = 113/199 (56%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIA-MDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 GSG + L KH G VK I L++ + + E+ +LR I HPN++ L D Sbjct: 17 GSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLIDV 76 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I ++++++EY GG+L+ +LR E F+ Q+ CGL+ + ++ HRDLKP Sbjct: 77 ISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKP 136 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA-DLWS 547 +N+ L ++ +KI +FG A QP L +T CGSP Y +PE++ + YD A D+WS Sbjct: 137 ENLYLDAHGS---IKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWS 193 Query: 548 VGIILYQLVTGSPPFNGDS 604 GII + L+TG PF+ D+ Sbjct: 194 CGIIFFALLTGKLPFDDDN 212
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 133 bits (335), Expect = 3e-31 Identities = 73/198 (36%), Positives = 113/198 (57%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++ +V+ G+ VA+K I S K +L E++I+R + HPNI+ + DS Sbjct: 11 GEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSF 70 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + ++ +Y G +L+ L ++PE + QL L L ++HRD+KPQ Sbjct: 71 ETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQ 129 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET-LCGSPLYMAPEVMQAQKYDAKADLWSV 550 NILL G +K+ DFGFA+ + + + T + G+PLYM+PE+++ + YD ADLWSV Sbjct: 130 NILLAKGGG---IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSV 186 Query: 551 GIILYQLVTGSPPFNGDS 604 G ILY+L G+PPF S Sbjct: 187 GCILYELAVGTPPFYATS 204
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 133 bits (334), Expect = 5e-31 Identities = 72/198 (36%), Positives = 115/198 (58%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 GSGA+S+V L + VA+K I L K ++L+ +E+ +LRRI+HPNI+AL D Sbjct: 22 GSGAFSEVMLAQERGSAHLVALKCIPKKALRGK--EALVENEIAVLRRISHPNIVALEDV 79 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +YL +E GG+L+ ++ E A H + Q+ + L +VHRDLKP Sbjct: 80 HESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKP 139 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L + S + ++DFG +K +Q + T CG+P Y+APE+++ + Y D+W++ Sbjct: 140 ENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWAL 198 Query: 551 GIILYQLVTGSPPFNGDS 604 G+I Y L+ G PPF +S Sbjct: 199 GVISYILLCGYPPFYDES 216
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 133 bits (334), Expect = 5e-31 Identities = 72/198 (36%), Positives = 115/198 (58%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 GSGA+S+V L + VA+K I L K ++L+ +E+ +LRRI+HPNI+AL D Sbjct: 22 GSGAFSEVMLAQERGSAHLVALKCIPKKALRGK--EALVENEIAVLRRISHPNIVALEDV 79 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +YL +E GG+L+ ++ E A H + Q+ + L +VHRDLKP Sbjct: 80 HESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKP 139 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L + S + ++DFG +K +Q + T CG+P Y+APE+++ + Y D+W++ Sbjct: 140 ENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWAL 198 Query: 551 GIILYQLVTGSPPFNGDS 604 G+I Y L+ G PPF +S Sbjct: 199 GVISYILLCGYPPFYDES 216
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 133 bits (334), Expect = 5e-31 Identities = 62/194 (31%), Positives = 116/194 (59%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V+ +H + G A+K + + + L+ EV+I + HPN+ + Sbjct: 111 GKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYGY 170 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YL++EY G++Y L H + +A +I Q+A L + + N++HRD+KP Sbjct: 171 FHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKNIIHRDIKP 230 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NIL+ NN ++K+ DFG++ P +T+CG+ Y++PE++++++YD D W++ Sbjct: 231 ENILIGFNN---VIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWAL 287 Query: 551 GIILYQLVTGSPPF 592 G++ ++L+TG+PPF Sbjct: 288 GVLAFELLTGAPPF 301
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 132 bits (333), Expect = 6e-31 Identities = 71/198 (35%), Positives = 113/198 (57%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +GKH G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 23 GVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQV 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I++++EY GG+L+ Y+ ++ R+ E ++ +Q+ G+ VVHRDLKP Sbjct: 83 ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL ++ KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 143 ENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ D Sbjct: 200 SGVILYALLCGTLPFDDD 217
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 132 bits (333), Expect = 6e-31 Identities = 71/198 (35%), Positives = 113/198 (57%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +GKH G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 23 GVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQV 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I++++EY GG+L+ Y+ ++ R+ E ++ +Q+ G+ VVHRDLKP Sbjct: 83 ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL ++ KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 143 ENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ D Sbjct: 200 SGVILYALLCGTLPFDDD 217
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 132 bits (333), Expect = 6e-31 Identities = 71/198 (35%), Positives = 113/198 (57%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +GKH G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 25 GVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQV 84 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I++++EY GG+L+ Y+ ++ R+ E ++ +Q+ G+ VVHRDLKP Sbjct: 85 ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL ++ KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 145 ENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 201 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ D Sbjct: 202 SGVILYALLCGTLPFDDD 219
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 132 bits (333), Expect = 6e-31 Identities = 71/198 (35%), Positives = 113/198 (57%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +GKH G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 25 GVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQV 84 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I++++EY GG+L+ Y+ ++ R+ E ++ +Q+ G+ VVHRDLKP Sbjct: 85 ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL ++ KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 145 ENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 201 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ D Sbjct: 202 SGVILYALLCGTLPFDDD 219
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 132 bits (332), Expect = 8e-31 Identities = 76/196 (38%), Positives = 108/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V V G E K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 20 GKGAFSVVRRCVKVLAGQEYPAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YLI + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET---LCGSPLYMAPEVMQAQKYDAKADLW 544 N+LL S + +K+ADFG A ++ G + G+P Y++PEV++ Y DLW Sbjct: 140 NLLLASKLKGAAVKLADFGLA--IEVEGEQQRWFGFAGTPGYLSPEVLRKDPYGKPVDLW 197 Query: 545 SVGIILYQLVTGSPPF 592 + G+ILY L+ G PPF Sbjct: 198 ACGVILYILLVGYPPF 213
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 132 bits (332), Expect = 8e-31 Identities = 72/202 (35%), Positives = 115/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLSEVDILRRITHPNIIAL 181 GSG ++ V + G E A K I RLS+ R + + EV+ILR I HPNII L Sbjct: 20 GSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITL 79 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 HD + + LILE GG+L+ +L + + E A F++Q+ G+ L + H D Sbjct: 80 HDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFD 139 Query: 362 LKPQNILLVSNN-GTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ N +K+ DFG A ++ + + G+P ++APE++ + +AD Sbjct: 140 LKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEAD 199 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF G++ Sbjct: 200 MWSIGVITYILLSGASPFLGET 221
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 132 bits (332), Expect = 8e-31 Identities = 72/198 (36%), Positives = 115/198 (58%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 GSGA+S+V L + VA+K I L K ++L+ +E+ +LRRI+HPNI+AL D Sbjct: 22 GSGAFSEVVLAQERGSAHLVALKCIPKKALRGK--EALVENEIAVLRRISHPNIVALEDV 79 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +YL +E GG+L+ ++ E A H + Q+ + L +VHRDLKP Sbjct: 80 HESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKP 139 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L + S + ++DFG +K +Q + T CG+P Y+APE+++ + Y D+W++ Sbjct: 140 ENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWAL 198 Query: 551 GIILYQLVTGSPPFNGDS 604 G+I Y L+ G PPF +S Sbjct: 199 GVISYILLCGYPPFYDES 216
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 132 bits (332), Expect = 8e-31 Identities = 81/216 (37%), Positives = 115/216 (53%), Gaps = 22/216 (10%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEI-AMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G Y+ V K+ G +VAVK A K E +IL R+ HPNI+ L DS Sbjct: 207 GAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDS 266 Query: 191 I-----RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVH 355 + + YL+LE G+L+ ++R + + +K +QL GL+ L E N++H Sbjct: 267 FVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIH 326 Query: 356 RDLKPQNILLV---SNNGTSI-------------LKIADFGFAKFLQPSGLAETLCGSPL 487 RD+KP+NILL N + + +KIADFG AKF TLCG+P Sbjct: 327 RDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPS 386 Query: 488 YMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFN 595 Y+APEV+ + Y +K DLWS G+ILY + G PPF+ Sbjct: 387 YVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFS 422
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 132 bits (332), Expect = 8e-31 Identities = 72/194 (37%), Positives = 112/194 (57%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++ +V+ G+ VA+K I S K +L E++I+R + HPNI+ + DS Sbjct: 11 GEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSF 70 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + ++ +Y G +L+ L ++PE + QL L L ++HRD+KPQ Sbjct: 71 ETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQ 129 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET-LCGSPLYMAPEVMQAQKYDAKADLWSV 550 NILL G +K+ DFGFA+ + + + T + G+PLYM+PE+++ + YD ADLWSV Sbjct: 130 NILLAKGGG---IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSV 186 Query: 551 GIILYQLVTGSPPF 592 G ILY+L G+PPF Sbjct: 187 GCILYELAVGTPPF 200
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 132 bits (332), Expect = 8e-31 Identities = 65/158 (41%), Positives = 100/158 (63%), Gaps = 1/158 (0%) Frame = +2 Query: 134 EVDILRRITHPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQL 313 E+ I++ I+H N++AL + + +YL+LEY GG+L+ YL+ ++PE A H+ +Q+ Sbjct: 164 EIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQI 223 Query: 314 ACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYM 493 G+ N+ HRDLKP+N+LL N +KIADFG A P+ L +T CGSP Y Sbjct: 224 VEGVSYCHSFNICHRDLKPENLLLDKKNRR--IKIADFGMAALELPNKLLKTSCGSPHYA 281 Query: 494 APEVMQAQKY-DAKADLWSVGIILYQLVTGSPPFNGDS 604 +PE++ + Y +D+WS GI+L+ L+TG PFN D+ Sbjct: 282 SPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDN 319
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 132 bits (332), Expect = 8e-31 Identities = 72/198 (36%), Positives = 115/198 (58%), Gaps = 5/198 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G +++V+ +H+ G VA+K I +R L + + + E+ +R + HPNI+ LH+ Sbjct: 19 GQGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRHPNIVELHEV 78 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +IY ++E+ +GG+L+ + K + E VA+ + +QL + V HRDLKP Sbjct: 79 MATKSKIYFVMEHVKGGELFNKVSTGK-LREDVARKYFQQLVRAVDFCHSRGVCHRDLKP 137 Query: 371 QNILLVSNNGTSILKIADFGFAKF---LQPSGLAETLCGSPLYMAPEVMQAQKYDA-KAD 538 +N+LL + LKI+DFG + + GL T CG+P Y+APEV+ YD KAD Sbjct: 138 ENLLLDEHGN---LKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRNGYDGFKAD 194 Query: 539 LWSVGIILYQLVTGSPPF 592 +WS G+IL+ L+ G PF Sbjct: 195 VWSCGVILFVLLAGYLPF 212
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 132 bits (331), Expect = 1e-30 Identities = 68/197 (34%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 R G+G++ +V L + V G A+K + ++ K + E +L+ + HP +I + Sbjct: 74 RTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRM 133 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 + +D I+++++Y GG+L++ L + +R P VAK + ++ L+ L N+++RD Sbjct: 134 WGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRD 193 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 LKP+NILL N +KI DFGFAK +Q + TLCG+P Y+APEV+ + Y+ D Sbjct: 194 LKPENILLDRNGH---IKITDFGFAKEVQT--VTWTLCGTPDYIAPEVITTKPYNKSVDW 248 Query: 542 WSVGIILYQLVTGSPPF 592 WS+G+++Y+++ G PF Sbjct: 249 WSLGVLIYEMLAGYTPF 265
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 132 bits (331), Expect = 1e-30 Identities = 69/200 (34%), Positives = 118/200 (59%), Gaps = 3/200 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDILRRITHPNIIAL 181 R G G +++V ++ G VA+K +A L ++ D + E+ I++ + HPNI+ L Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 ++ + +IY++LE+ GG+L+ ++ R+ E+ ++ + +QL + V HRD Sbjct: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYD-AKA 535 LKP+N+LL +N LK++DFG + Q L T CG+P Y+APEV+ Q YD + A Sbjct: 135 LKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAA 191 Query: 536 DLWSVGIILYQLVTGSPPFN 595 D+WS G+IL+ ++ G PF+ Sbjct: 192 DIWSCGVILFVILAGYLPFS 211
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 132 bits (331), Expect = 1e-30 Identities = 73/198 (36%), Positives = 112/198 (56%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++ +V+ G+ VA+K I S K +L E++I+R + HPNI+ + DS Sbjct: 11 GEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSF 70 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + ++ +Y G +L L ++PE + QL L L ++HRD+KPQ Sbjct: 71 ETDKEVVVVTDYAEG-ELLQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQ 129 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLAET-LCGSPLYMAPEVMQAQKYDAKADLWSV 550 NILL G +K+ DFGFA+ + + + T + G+PLYM+PE+++ + YD ADLWSV Sbjct: 130 NILLAKGGG---IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSV 186 Query: 551 GIILYQLVTGSPPFNGDS 604 G ILY+L G+PPF S Sbjct: 187 GCILYELAVGTPPFYATS 204
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 131 bits (330), Expect = 1e-30 Identities = 78/207 (37%), Positives = 116/207 (56%), Gaps = 10/207 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLS-----EVDILRRITHP 166 G G+ +V L +H G AVK I+ + DS+L E+ I++ ++HP Sbjct: 28 GFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHP 87 Query: 167 NIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESN 346 N+++L+D +YLILEY G+L+ L+ H +PE A + RQ+ G+ Sbjct: 88 NVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALG 147 Query: 347 VVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYD 526 +VHRDLKP+N+LL S +KIADFG A + L ET CGSP Y APE++ Y+ Sbjct: 148 IVHRDLKPENLLLDSFYN---IKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYE 204 Query: 527 AKA-DLWSVGIILYQLVTGSPPFNGDS 604 A D+WS G+IL+ L+TG PF+ ++ Sbjct: 205 GFASDVWSCGVILFALLTGRLPFDEEN 231
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha| 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 131 bits (330), Expect = 1e-30 Identities = 83/201 (41%), Positives = 110/201 (54%), Gaps = 4/201 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS+ H A E AVK I + E++IL R HPNII L D Sbjct: 425 GVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQHPNIITLKDV 478 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +YL+ E RGG+L +LR K E A + + ++ L VVHRDLKP Sbjct: 479 YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKP 538 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G L+I DFGFAK L+ +GL T C + ++APEV++ Q YD D+W Sbjct: 539 SNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 598 Query: 545 SVGIILYQLVTGSPPF-NGDS 604 S+GI+LY ++ G PF NG S Sbjct: 599 SLGILLYTMLAGYTPFANGPS 619 Score = 130 bits (327), Expect = 3e-30 Identities = 72/199 (36%), Positives = 114/199 (57%), Gaps = 4/199 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVAR---GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 G G++ +V+L + V R G A+K + L + R E DIL + HP ++ LH Sbjct: 69 GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 128 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +LA GL L +++RDL Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ Q + AD Sbjct: 189 KPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADW 245 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS G+++++++TGS PF G Sbjct: 246 WSYGVLMFEMLTGSLPFQG 264
>SGK1_RABIT (Q9XT18) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 131 bits (330), Expect = 1e-30 Identities = 69/196 (35%), Positives = 113/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDS-LLSEVDIL-RRITHPNIIALHD 187 G G++ +V L +H A AVK + + K + ++SE ++L + + HP ++ LH Sbjct: 105 GKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHF 164 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R + E A+ + ++A L L N+V+RDLK Sbjct: 165 SFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLK 224 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL S + + DFG K ++ +G T CG+P Y+APEV+ Q YD D W Sbjct: 225 PENILLDSQGH---IVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWW 281 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 282 CLGAVLYEMLYGLPPF 297
>SGK1_MOUSE (Q9WVC6) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 131 bits (330), Expect = 1e-30 Identities = 69/196 (35%), Positives = 113/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDS-LLSEVDIL-RRITHPNIIALHD 187 G G++ +V L +H A AVK + + K + ++SE ++L + + HP ++ LH Sbjct: 105 GKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHF 164 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R + E A+ + ++A L L N+V+RDLK Sbjct: 165 SFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLK 224 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL S + + DFG K ++ +G T CG+P Y+APEV+ Q YD D W Sbjct: 225 PENILLDSQGH---IVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWW 281 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 282 CLGAVLYEMLYGLPPF 297
>SGK1_RAT (Q06226) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 430 Score = 131 bits (330), Expect = 1e-30 Identities = 69/196 (35%), Positives = 113/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDS-LLSEVDIL-RRITHPNIIALHD 187 G G++ +V L +H A AVK + + K + ++SE ++L + + HP ++ LH Sbjct: 105 GKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHF 164 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R + E A+ + ++A L L N+V+RDLK Sbjct: 165 SFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLK 224 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL S + + DFG K ++ +G T CG+P Y+APEV+ Q YD D W Sbjct: 225 PENILLDSQGH---IVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWW 281 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 282 CLGAVLYEMLYGLPPF 297
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 131 bits (330), Expect = 1e-30 Identities = 73/194 (37%), Positives = 111/194 (57%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V + G E A K I +L+A+ L E I R++ HPNI+ LHDSI Sbjct: 21 GKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 ++ YL+ + GG+L+ ++ + E A H I+Q+ + ++ VVHRDLKP+ Sbjct: 81 QEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ + Y D+W+ Sbjct: 141 NLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 131 bits (329), Expect = 2e-30 Identities = 73/194 (37%), Positives = 108/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V + G A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 21 GKGAFSVVRRCMKIPTGQGYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I+Q+ + + +VHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + + +K+ADFG A +Q A G+P Y++PEV++ Y D+W+ Sbjct: 141 NLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KAPC_CAEEL (P21137) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 404 Score = 131 bits (329), Expect = 2e-30 Identities = 66/197 (33%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ I P ++ + S Sbjct: 88 GTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFS 147 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y++LE+ GG+++++L R R E ++ + Q+ + L ++++RDLKP Sbjct: 148 FKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKP 207 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + T LKI DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 208 ENLLI---DSTGYLKITDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 262 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 263 GVLIYEMAAGYPPFFAD 279
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 131 bits (329), Expect = 2e-30 Identities = 70/200 (35%), Positives = 121/200 (60%), Gaps = 1/200 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 R G+G + +V+L ++ G A+K + + K + L SE IL I HP I+ L Sbjct: 340 RVLGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPFIVNL 399 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 + + +D ++YL+ EY GG+++ +L + + + AK + ++ L+ L + N+V+RD Sbjct: 400 YQAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAAEIVLALEFLHKQNIVYRD 459 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 LKP+N LL+ N G +KI DFGFAK ++ TLCG+P Y+APE++Q++ + D Sbjct: 460 LKPEN-LLIDNQGH--IKITDFGFAKRVEDRTF--TLCGTPEYLAPEIIQSKGHGKAVDW 514 Query: 542 WSVGIILYQLVTGSPPFNGD 601 W++GI++++++ G PPF D Sbjct: 515 WALGILIFEMLAGYPPFYDD 534
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 130 bits (328), Expect = 2e-30 Identities = 70/198 (35%), Positives = 110/198 (55%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +G+H G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 23 GVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQV 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I ++++EY GG+L+ Y+ +H RV E A+ +Q+ + VVHRDLKP Sbjct: 83 ISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL + KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 143 ENVLLDAQMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ + Sbjct: 200 CGVILYALLCGTLPFDDE 217
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 130 bits (328), Expect = 2e-30 Identities = 70/198 (35%), Positives = 111/198 (56%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +G+H G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 23 GVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQV 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I ++++EY GG+L+ Y+ +H RV E A+ +Q+ + VVHRDLKP Sbjct: 83 ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL ++ KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 143 ENVLLDAHMNA---KIADFGLSNIMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ + Sbjct: 200 CGVILYALLCGTLPFDDE 217
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 130 bits (328), Expect = 2e-30 Identities = 70/198 (35%), Positives = 111/198 (56%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +G+H G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 23 GVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQV 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I ++++EY GG+L+ Y+ +H RV E A+ +Q+ + VVHRDLKP Sbjct: 83 ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL ++ KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 143 ENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ + Sbjct: 200 CGVILYALLCGTLPFDDE 217
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 130 bits (328), Expect = 2e-30 Identities = 69/198 (34%), Positives = 118/198 (59%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L +HV G +VA+K I L+ + ++ + E+ LR + HP+II L+D Sbjct: 59 GEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYDV 118 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I+ I +++E+ G +L+ Y+++ ++PE A+ F +Q+ ++ +VHRDLKP Sbjct: 119 IKSKDEIIMVIEFA-GKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKP 177 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL + +KIADFG + + +T CGSP Y APEV+ + Y + D+WS Sbjct: 178 ENLLL---DDQLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWS 234 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY ++ G PF+ + Sbjct: 235 SGVILYVMLCGRLPFDDE 252
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 130 bits (327), Expect = 3e-30 Identities = 70/198 (35%), Positives = 113/198 (57%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L H +VA+K I+ L + + + E+ L+ + HP+II L+D Sbjct: 41 GEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYDV 100 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I +++EY GG+L+ Y++ KR+ E + F +Q+ C ++ +VHRDLKP Sbjct: 101 ITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKP 159 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL N +KIADFG + + +T CGSP Y APEV+ + Y + D+WS Sbjct: 160 ENLLLDDNLN---VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWS 216 Query: 548 VGIILYQLVTGSPPFNGD 601 GI+LY ++ G PF+ + Sbjct: 217 CGIVLYVMLVGRLPFDDE 234
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 130 bits (327), Expect = 3e-30 Identities = 71/202 (35%), Positives = 114/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLSEVDILRRITHPNIIAL 181 GSG ++ V + G E A K I RL + R + + EV ILR I HPNII L Sbjct: 20 GSGQFAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITL 79 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 HD + + LILE GG+L+ +L + + E A F++Q+ G+ L + H D Sbjct: 80 HDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFD 139 Query: 362 LKPQNILLVSNNGTS-ILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ + S +K+ DFG A ++ + + G+P ++APE++ + +AD Sbjct: 140 LKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEAD 199 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF G++ Sbjct: 200 MWSIGVITYILLSGASPFLGET 221
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 130 bits (327), Expect = 3e-30 Identities = 71/202 (35%), Positives = 114/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLSEVDILRRITHPNIIAL 181 GSG ++ V + G E A K I RL + R + + EV ILR I HPNII L Sbjct: 20 GSGQFAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITL 79 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 HD + + LILE GG+L+ +L + + E A F++Q+ G+ L + H D Sbjct: 80 HDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFD 139 Query: 362 LKPQNILLVSNNGTS-ILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ + S +K+ DFG A ++ + + G+P ++APE++ + +AD Sbjct: 140 LKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEAD 199 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF G++ Sbjct: 200 MWSIGVITYILLSGASPFLGET 221
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 130 bits (327), Expect = 3e-30 Identities = 70/198 (35%), Positives = 110/198 (55%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +G+H G +VAVK + ++ S + + E+ L+ HP+II L+ Sbjct: 23 GVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQV 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I ++++EY GG+L+ Y+ +H RV E A+ +Q+ + VVHRDLKP Sbjct: 83 ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL + KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 143 ENVLLDAQMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ + Sbjct: 200 CGVILYALLCGTLPFDDE 217
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 130 bits (327), Expect = 3e-30 Identities = 83/201 (41%), Positives = 110/201 (54%), Gaps = 4/201 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H A E AVK I + E++IL R HPNII L D Sbjct: 414 GVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQHPNIITLKDV 467 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +YL+ E RGG+L +LR K E A + ++ ++ L VVHRDLKP Sbjct: 468 YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKP 527 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G L+I DFGFAK L+ +GL T C + ++APEV++ Q YD D+W Sbjct: 528 SNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 587 Query: 545 SVGIILYQLVTGSPPF-NGDS 604 S+GI+LY ++ G PF NG S Sbjct: 588 SLGILLYTMLAGYTPFANGPS 608 Score = 115 bits (287), Expect = 1e-25 Identities = 66/187 (35%), Positives = 104/187 (55%), Gaps = 4/187 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVAR---GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 G G++ +V+L + V R G A+K + L + R E DIL + HP ++ LH Sbjct: 69 GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 128 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +LA GL L +++RDL Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ Q + AD Sbjct: 189 KPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADW 245 Query: 542 WSVGIIL 562 WS G+++ Sbjct: 246 WSYGVLM 252
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 130 bits (327), Expect = 3e-30 Identities = 78/206 (37%), Positives = 117/206 (56%), Gaps = 13/206 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVK--EIAMDRLSAK----LRDSLLSEVDILRRIT-HPNI 172 G G S V H A G E AVK E++ +RLS + +RD+ E+ ILR++ HP+I Sbjct: 31 GRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHI 90 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 I L DS ++L+ + R G+L+ YL + E + +R L + L +N+V Sbjct: 91 ITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVNFLHVNNIV 150 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQK---- 520 HRDLKP+NILL N ++++DFGF+ L+P LCG+P Y+APE+++ Sbjct: 151 HRDLKPENILLDDN---MQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETH 207 Query: 521 --YDAKADLWSVGIILYQLVTGSPPF 592 Y + DLW+ G+IL+ L+ GSPPF Sbjct: 208 PGYGKEVDLWACGVILFTLLAGSPPF 233
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 130 bits (326), Expect = 4e-30 Identities = 71/198 (35%), Positives = 111/198 (56%), Gaps = 2/198 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V +G H +VAVK + ++ S + + E+ L HP+II L+ Sbjct: 94 GVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQV 153 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I I++I+E+ GG+L+ Y+++H R+ A+ F +Q+ G+ VVHRDLKP Sbjct: 154 ISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKP 213 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL N +KIADFG + + T CGSP Y APEV+ + Y + D+WS Sbjct: 214 ENLLLDEQNN---VKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWS 270 Query: 548 VGIILYQLVTGSPPFNGD 601 G+ILY L+ G+ PF+ + Sbjct: 271 CGVILYALLCGTLPFDDE 288
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 130 bits (326), Expect = 4e-30 Identities = 72/199 (36%), Positives = 114/199 (57%), Gaps = 4/199 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVAR---GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 G G++ +V+L + V R G A+K + L + R E DIL + HP ++ LH Sbjct: 69 GQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 128 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +LA GL L +++RDL Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ Q + AD Sbjct: 189 KPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADW 245 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS G+++++++TGS PF G Sbjct: 246 WSYGVLMFEMLTGSLPFQG 264 Score = 127 bits (318), Expect = 3e-29 Identities = 81/201 (40%), Positives = 109/201 (54%), Gaps = 4/201 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H A E AVK I + E++IL R HPNII L D Sbjct: 425 GVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQHPNIITLKDV 478 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D +YL+ E RGG+L +LR K E A + ++ ++ L VVHRDLKP Sbjct: 479 YDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKP 538 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G L+I DFGFAK L+ +GL T C + ++APEV++ Q YD D+W Sbjct: 539 SNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 598 Query: 545 SVGIILYQLVTGSPPF-NGDS 604 S+G++LY ++ G PF NG S Sbjct: 599 SLGVLLYTMLAGYTPFANGPS 619
>NEK1_HUMAN (Q96PY6) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) (NY-REN-55 antigen) Length = 1258 Score = 130 bits (326), Expect = 4e-30 Identities = 67/200 (33%), Positives = 116/200 (58%), Gaps = 3/200 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++ + L K G + +KEI + R+S+K R+ EV +L + HPNI+ +S Sbjct: 11 GEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESF 70 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRV--PETVAKHFIRQLACGLQKLRESNVVHRDLK 367 + G +Y++++YC GGDL+ + K V E + Q+ L+ + + ++HRD+K Sbjct: 71 EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIK 130 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 QNI L + +GT +++ DFG A+ L + LA T G+P Y++PE+ + + Y+ K+D+W Sbjct: 131 SQNIFL-TKDGT--VQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIW 187 Query: 545 SVGIILYQLVTGSPPFNGDS 604 ++G +LY+L T F S Sbjct: 188 ALGCVLYELCTLKHAFEAGS 207
>KAPCA_BOVIN (P00517) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 130 bits (326), Expect = 4e-30 Identities = 63/197 (31%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH+ G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 129 bits (325), Expect = 5e-30 Identities = 73/194 (37%), Positives = 107/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 21 GKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I Q+ + + + ++VHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ Y D+W+ Sbjct: 141 NLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 129 bits (325), Expect = 5e-30 Identities = 73/194 (37%), Positives = 107/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 21 GKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I Q+ + + + ++VHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ Y D+W+ Sbjct: 141 NLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 129 bits (325), Expect = 5e-30 Identities = 74/194 (38%), Positives = 108/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V + G E A K I +LSA+ L E I R + H NI+ LHDSI Sbjct: 21 GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ + Y D+W+ Sbjct: 141 NLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 129 bits (325), Expect = 5e-30 Identities = 74/194 (38%), Positives = 108/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V + G E A K I +LSA+ L E I R + H NI+ LHDSI Sbjct: 21 GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ + Y D+W+ Sbjct: 141 NLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 129 bits (325), Expect = 5e-30 Identities = 74/194 (38%), Positives = 108/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V + G E A K I +LSA+ L E I R + H NI+ LHDSI Sbjct: 21 GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I+Q+ + + VVHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ + Y D+W+ Sbjct: 141 NLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 129 bits (325), Expect = 5e-30 Identities = 68/200 (34%), Positives = 117/200 (58%), Gaps = 1/200 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 R G G++ +V L +H G A+K + ++ K + +L+E IL+ I P ++ L Sbjct: 47 RTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKL 106 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 S +D +YL++EY GG++++ L R R E A + Q+ +Q L +++HRD Sbjct: 107 QFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRD 166 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 LKP+N+L+ + L++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D Sbjct: 167 LKPENLLI---DQQGYLQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDW 221 Query: 542 WSVGIILYQLVTGSPPFNGD 601 W++G+++Y++ G PPF D Sbjct: 222 WALGVLIYEMAVGFPPFYAD 241
>KAPCA_SHEEP (Q9MZD9) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 129 bits (325), Expect = 5e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHTETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 129 bits (325), Expect = 5e-30 Identities = 73/194 (37%), Positives = 107/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GA+S V E A K I +LSA+ L E I R + HPNI+ LHDSI Sbjct: 21 GKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 + G YL+ + GG+L+ ++ + E A H I Q+ + + + ++VHRDLKP+ Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPE 140 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGLA-ETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N+LL S + +K+ADFG A +Q A G+P Y++PEV++ Y D+W+ Sbjct: 141 NLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC 200 Query: 551 GIILYQLVTGSPPF 592 G+ILY L+ G PPF Sbjct: 201 GVILYILLVGYPPF 214
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 129 bits (324), Expect = 7e-30 Identities = 80/196 (40%), Positives = 109/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H E AVK I K + E++ILRR HPNIIAL D Sbjct: 423 GVGSYSVCKRCVHKGTNMEYAVKVID------KTKRDPSEEIEILRRYGQHPNIIALKDV 476 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 ++G IY++ E RGG+L +LR K E A + + ++ L VVHRDLKP Sbjct: 477 YKEGNSIYVVTELMRGGELLDRILRQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKP 536 Query: 371 QNILLVSNNG-TSILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G ++I DFGFAK L+ +GL T C + ++APEV++ Q YD D+W Sbjct: 537 SNILYVDESGDPESIRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 596 Query: 545 SVGIILYQLVTGSPPF 592 S+GI+LY ++ G PF Sbjct: 597 SLGILLYTMLAGYTPF 612 Score = 125 bits (313), Expect = 1e-28 Identities = 69/199 (34%), Positives = 112/199 (56%), Gaps = 4/199 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA---RGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 G G++ +V+L + + A+K + L + R E DIL + HP ++ LH Sbjct: 69 GQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLH 128 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +LA GL L +++RDL Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ Q + AD Sbjct: 189 KPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADW 245 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS G+++++++TGS PF G Sbjct: 246 WSYGVLMFEMLTGSLPFQG 264
>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) Length = 984 Score = 129 bits (324), Expect = 7e-30 Identities = 70/194 (36%), Positives = 113/194 (58%), Gaps = 3/194 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G GA+ + L + + V KE+ + RLS K R L+E+ IL + H NIIA + Sbjct: 56 RVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYY 115 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRH--KRVPETVAKHFIRQLACGLQKLRESNVVHR 358 + D + + LEYC GG+LY +LR K E + ++ Q+ + + ++ ++HR Sbjct: 116 NHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHR 175 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYDAKA 535 D+K NI L N ++K+ D+G AK L +AETL G+P YM+PE+ Q KY+ K+ Sbjct: 176 DIKTLNIFLTKAN---LIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKS 232 Query: 536 DLWSVGIILYQLVT 577 D+W+VG ++++L+T Sbjct: 233 DIWAVGCVIFELLT 246
>SGK1_HUMAN (O00141) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 129 bits (324), Expect = 7e-30 Identities = 68/196 (34%), Positives = 112/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDS-LLSEVDIL-RRITHPNIIALHD 187 G G++ +V L +H A AVK + + K + ++SE ++L + + HP ++ LH Sbjct: 105 GKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHF 164 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R + E A+ + ++A L L N+V+RDLK Sbjct: 165 SFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLK 224 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL S + + DFG K ++ + T CG+P Y+APEV+ Q YD D W Sbjct: 225 PENILLDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWW 281 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 282 CLGAVLYEMLYGLPPF 297
>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8) Length = 979 Score = 129 bits (324), Expect = 7e-30 Identities = 70/194 (36%), Positives = 113/194 (58%), Gaps = 3/194 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G GA+ + L + + V KE+ + RLS K R L+E+ IL + H NIIA + Sbjct: 56 RVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYY 115 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRH--KRVPETVAKHFIRQLACGLQKLRESNVVHR 358 + D + + LEYC GG+LY +LR K E + ++ Q+ + + ++ ++HR Sbjct: 116 NHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHR 175 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYDAKA 535 D+K NI L N ++K+ D+G AK L +AETL G+P YM+PE+ Q KY+ K+ Sbjct: 176 DIKTLNIFLTKAN---LIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKS 232 Query: 536 DLWSVGIILYQLVT 577 D+W+VG ++++L+T Sbjct: 233 DIWAVGCVIFELLT 246
>KAPCA_MOUSE (P05132) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 129 bits (324), Expect = 7e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 129 bits (324), Expect = 7e-30 Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 12/212 (5%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVK-----EIAMDRLSAKLRDSLLSEVDILRRITHPN 169 R GSG ++ V L V G A+K +I + + + E+DIL+ + HP Sbjct: 171 RTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPG 230 Query: 170 IIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNV 349 ++ H+ + +++++EY GGDL +L+ + + E K ++QL L L + V Sbjct: 231 VVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGV 290 Query: 350 VHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSG-LAETLCGSPLYMAPEVMQAQK-- 520 HRD+KP+NIL+ ++ LKI+DFG AK + +G ET CG+ Y+APEV++++ Sbjct: 291 THRDIKPENILITND---FHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVN 347 Query: 521 ----YDAKADLWSVGIILYQLVTGSPPFNGDS 604 YD K D+WS+G +LY ++T S PF S Sbjct: 348 LDGGYDDKVDIWSLGCVLYVMLTASIPFASSS 379
>KAPCA_CANFA (Q8MJ44) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 349 Score = 129 bits (323), Expect = 9e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 49 GTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 108 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 109 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 168 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 169 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 223 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 224 GVLIYEMAAGYPPFFAD 240
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 129 bits (323), Expect = 9e-30 Identities = 70/198 (35%), Positives = 112/198 (56%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK-LRDSLLSEVDILRRITHPNIIALHDS 190 G G + V+L + VA+K + ++ + L L E++I + HPNI+ L++ Sbjct: 50 GKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNY 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YLILEY G+LY L + +++ E I +LA L + V+HRD+KP Sbjct: 110 FHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL +KIADFG++ PS +T+CG+ Y+ PE+++ + YD K DLW + Sbjct: 170 ENLLL---GFRGEVKIADFGWSVH-TPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCI 225 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+L+ G PPF S Sbjct: 226 GVLCYELLVGYPPFESAS 243
>KAPCA_RAT (P27791) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 129 bits (323), Expect = 9e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPCA_PIG (P36887) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 129 bits (323), Expect = 9e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPCA_HUMAN (P17612) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 129 bits (323), Expect = 9e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPCA_CRIGR (P25321) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 129 bits (323), Expect = 9e-30 Identities = 63/197 (31%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH G A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ + +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 ENLLI---DQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 128 bits (322), Expect = 1e-29 Identities = 71/197 (36%), Positives = 112/197 (56%), Gaps = 1/197 (0%) Frame = +2 Query: 11 DGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 DG+ A + + + AR E A+K I + K + +EV ILRR+ HPNI+ L + Sbjct: 91 DGNFAVVKECIERSTAR--EYALKIIKKSKCRGK-EHMIQNEVSILRRVKHPNIVLLIEE 147 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +YL++E +GGDL+ + + E A + LA ++ L N+VHRD+KP Sbjct: 148 MDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 207 Query: 371 QNILLVSN-NGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +N+L+ + +G+ LK+ DFG A + G T+CG+P Y+APE++ Y K D+W+ Sbjct: 208 ENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 265 Query: 548 VGIILYQLVTGSPPFNG 598 G+I Y L+ G PPF G Sbjct: 266 AGVITYILLCGFPPFRG 282
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 128 bits (322), Expect = 1e-29 Identities = 67/196 (34%), Positives = 114/196 (58%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR-DSLLSEVDILRRITHPNIIALHDS 190 G GA+ +V+ + A+K + D + K + + +E DIL +I HP I+ L S Sbjct: 141 GKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDHPFIVQLKYS 200 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + R+YL+L++ GG L+ L E +A+ + ++ + L E ++HRDLKP Sbjct: 201 FQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKP 260 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NIL+ ++ + + DFG AK + + + ++CG+ YMAPE+++ + +D AD WSV Sbjct: 261 ENILMDTDGH---VMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSV 317 Query: 551 GIILYQLVTGSPPFNG 598 GI+LY+++TG PPF G Sbjct: 318 GILLYEMLTGKPPFLG 333
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 128 bits (322), Expect = 1e-29 Identities = 71/197 (36%), Positives = 112/197 (56%), Gaps = 1/197 (0%) Frame = +2 Query: 11 DGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 DG+ A + + + AR E A+K I + K + +EV ILRR+ HPNI+ L + Sbjct: 414 DGNFAVVKECIERSTAR--EYALKIIKKSKCRGK-EHMIQNEVSILRRVKHPNIVLLIEE 470 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +YL++E +GGDL+ + + E A + LA ++ L N+VHRD+KP Sbjct: 471 MDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 530 Query: 371 QNILLVSN-NGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +N+L+ + +G+ LK+ DFG A + G T+CG+P Y+APE++ Y K D+W+ Sbjct: 531 ENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 588 Query: 548 VGIILYQLVTGSPPFNG 598 G+I Y L+ G PPF G Sbjct: 589 AGVITYILLCGFPPFRG 605
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 128 bits (322), Expect = 1e-29 Identities = 63/165 (38%), Positives = 100/165 (60%), Gaps = 5/165 (3%) Frame = +2 Query: 125 LLSEVDILRRIT-----HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETV 289 L +E+ ++RRI HPN+I LHD D ++L+LE C GG+L+ ++ R E+ Sbjct: 84 LTNEILVMRRIVEDVSPHPNVIHLHDVYEDANGVHLVLELCSGGELFDRIVAQDRYSESE 143 Query: 290 AKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAET 469 A ++Q+A GL L +S ++HRDLKP+N L ++ S LKI DFG + + Sbjct: 144 AAEVVQQIASGLAALHKSTIIHRDLKPENCLFLNQEKRSTLKIMDFGLSSVEDFTDPIVA 203 Query: 470 LCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 L GS Y++PE + ++ + +D+WS+G+ILY L++G PPF+ S Sbjct: 204 LFGSIDYVSPEALSQRQVSSASDMWSLGVILYILLSGCPPFHAPS 248
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 128 bits (321), Expect = 1e-29 Identities = 71/194 (36%), Positives = 108/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + V+L + +A+K + +L A + L EV+I + HPNI+ L+ Sbjct: 131 GKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGY 190 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YLILEY G +Y L + + E +I +LA L V+HRD+KP Sbjct: 191 FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKP 250 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL SN LKIADFG++ PS T+CG+ Y+ PE+++ + +D K DLWS+ Sbjct: 251 ENLLLGSNGE---LKIADFGWSVH-APSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSL 306 Query: 551 GIILYQLVTGSPPF 592 G++ Y+ + G PPF Sbjct: 307 GVLCYEFLVGMPPF 320
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 128 bits (321), Expect = 1e-29 Identities = 69/197 (35%), Positives = 117/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 R G+G++ +V L + G A+K + + + K + E +L +THP II + Sbjct: 91 RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRM 150 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 + +D +I++I++Y GG+L++ L + +R P VAK + ++ L+ L ++++RD Sbjct: 151 WGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRD 210 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 LKP+NILL N +KI DFGFAK++ + TLCG+P Y+APEV+ + Y+ D Sbjct: 211 LKPENILLDKNGH---IKITDFGFAKYV--PDVTYTLCGTPDYIAPEVVSTKPYNKSIDW 265 Query: 542 WSVGIILYQLVTGSPPF 592 WS GI++Y+++ G PF Sbjct: 266 WSFGILIYEMLAGYTPF 282
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 128 bits (321), Expect = 1e-29 Identities = 71/200 (35%), Positives = 113/200 (56%), Gaps = 3/200 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ + + G EVA+K I + A + + +EV I ++ HP+++ L++ Sbjct: 19 GKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNY 78 Query: 191 IRDGGRIYLILEYCRGGDLYAYLL-RHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 D +YL+LE C G++ YL R K E A+HF+ Q+ G+ L ++HRDL Sbjct: 79 FEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLT 138 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NILL N +KIADFG A L P TLCG+P Y++PE+ + ++D+W Sbjct: 139 LSNILLTRNMN---IKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIW 195 Query: 545 SVGIILYQLVTGSPPFNGDS 604 S+G + Y L+ G PPF+ D+ Sbjct: 196 SLGCMFYTLLIGRPPFDTDT 215
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 128 bits (321), Expect = 1e-29 Identities = 71/202 (35%), Positives = 115/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK----LRDSLLSEVDILRRITHPNIIAL 181 GSG ++ V + + G E A K I + A R+ + EV ILR++ HPNII L Sbjct: 30 GSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIITL 89 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 HD + + LILE GG+L+ +L + + + E A FI+Q+ G+ L + H D Sbjct: 90 HDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFD 149 Query: 362 LKPQNILLVSNN-GTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ N +K+ DFG A ++ + + G+P ++APE++ + +AD Sbjct: 150 LKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEAD 209 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF GD+ Sbjct: 210 MWSIGVITYILLSGASPFLGDT 231
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 128 bits (321), Expect = 1e-29 Identities = 77/206 (37%), Positives = 115/206 (55%), Gaps = 13/206 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVK--EIAMDRLSAK----LRDSLLSEVDILRRIT-HPNI 172 G G S V H A G E AVK E+ +RLS + +R++ E ILR++ HP+I Sbjct: 31 GRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHI 90 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 I L DS ++L+ + R G+L+ YL + E + +R L + L +N+V Sbjct: 91 ITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIV 150 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQK---- 520 HRDLKP+NILL N ++++DFGF+ L+P LCG+P Y+APE+++ Sbjct: 151 HRDLKPENILLDDN---MQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETH 207 Query: 521 --YDAKADLWSVGIILYQLVTGSPPF 592 Y + DLW+ G+IL+ L+ GSPPF Sbjct: 208 PGYGKEVDLWACGVILFTLLAGSPPF 233
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 128 bits (321), Expect = 1e-29 Identities = 69/199 (34%), Positives = 119/199 (59%), Gaps = 3/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L +H+ G +VA+K I L+ + ++ + E+ LR + HP+II L+D Sbjct: 60 GEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYDV 119 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I+ I +++E+ G +L+ Y+++ ++PE A+ F +Q+ ++ +VHRDLKP Sbjct: 120 IKSKDEIIMVIEFA-GKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKP 178 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYM-APEVMQAQKY-DAKADLW 544 +N+LL + +KIADFG + + +T CGSP YM APEV+ + Y + D+W Sbjct: 179 ENLLL---DDQLNVKIADFGLSNIMTDGNFLKTSCGSPNYMPAPEVISGKLYAGPEVDVW 235 Query: 545 SVGIILYQLVTGSPPFNGD 601 S G+ILY ++ G PF+ + Sbjct: 236 SAGVILYVMLCGRLPFDDE 254
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 128 bits (321), Expect = 1e-29 Identities = 69/199 (34%), Positives = 116/199 (58%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L HV G +VA+K I L+ + ++ + E+ LR + HP+II L+D Sbjct: 46 GEGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDV 105 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I+ I +++EY G +L+ Y+++ ++ E A+ F +Q+ ++ +VHRDLKP Sbjct: 106 IKSKDEIIMVIEYA-GNELFDYIVQRNKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKP 164 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL + +KIADFG + + +T CGSP Y APEV+ + Y + D+WS Sbjct: 165 ENLLLDEHLN---VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWS 221 Query: 548 VGIILYQLVTGSPPFNGDS 604 G+ILY ++ PF+ +S Sbjct: 222 CGVILYVMLCRRLPFDDES 240
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 128 bits (321), Expect = 1e-29 Identities = 71/197 (36%), Positives = 112/197 (56%), Gaps = 1/197 (0%) Frame = +2 Query: 11 DGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 DG+ A + + + AR E A+K I + K + +EV ILRR+ HPNI+ L + Sbjct: 398 DGNFAVVKECVERSTAR--EYALKIIKKSKCRGK-EHMIQNEVSILRRVKHPNIVLLIEE 454 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +YL++E +GGDL+ + + E A + LA ++ L N+VHRD+KP Sbjct: 455 MDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 514 Query: 371 QNILLVSN-NGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 +N+L+ + +G+ LK+ DFG A + G T+CG+P Y+APE++ Y K D+W+ Sbjct: 515 ENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 572 Query: 548 VGIILYQLVTGSPPFNG 598 G+I Y L+ G PPF G Sbjct: 573 AGVITYILLCGFPPFRG 589
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 127 bits (320), Expect = 2e-29 Identities = 79/196 (40%), Positives = 108/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H A E AVK I + E++IL R HPNII L D Sbjct: 422 GVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPS------EEIEILLRYGQHPNIITLKDV 475 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +YL++E RGG+L +LR + E A + +A + L VVHRDLKP Sbjct: 476 YDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKP 535 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL + +G ++I DFGFAK L+ +GL T C + ++APEV++ Q YDA D+W Sbjct: 536 SNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVW 595 Query: 545 SVGIILYQLVTGSPPF 592 S+GI+LY ++ G PF Sbjct: 596 SLGILLYTMLAGFTPF 611 Score = 126 bits (316), Expect = 6e-29 Identities = 73/201 (36%), Positives = 117/201 (58%), Gaps = 6/201 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA---RGTEVAVKEIAMDRLSAKLRDSLLSEV--DILRRITHPNIIA 178 G G+Y +V+L + V G A+K + + + K+RD + S++ DIL + HP I+ Sbjct: 66 GQGSYGKVFLVRKVTGSDAGQLYAMK--VLKKATLKVRDRVRSKMERDILAEVNHPFIVK 123 Query: 179 LHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHR 358 LH + + G++YLIL++ RGGDL+ L + E K ++ +LA L L +++R Sbjct: 124 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYR 183 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA 535 DLKP+NILL + +KI DFG +K A + CG+ YMAPEV+ + + A Sbjct: 184 DLKPENILL---DEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA 240 Query: 536 DLWSVGIILYQLVTGSPPFNG 598 D WS G+++++++TGS PF G Sbjct: 241 DWWSFGVLMFEMLTGSLPFQG 261
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 127 bits (320), Expect = 2e-29 Identities = 73/201 (36%), Positives = 118/201 (58%), Gaps = 6/201 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA---RGTEVAVKEIAMDRLSAKLRDSLLSEV--DILRRITHPNIIA 178 G G+Y +V+L + V G A+K + + + K+RD + S++ DIL + HP I+ Sbjct: 66 GQGSYGKVFLVRKVKGSDAGQLYAMK--VLKKATLKVRDRVRSKMERDILAEVNHPFIVK 123 Query: 179 LHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHR 358 LH + + G++YLIL++ RGGDL+ L + E K ++ +LA L L +++R Sbjct: 124 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 183 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA 535 DLKP+NILL + +KI DFG +K + A + CG+ YMAPEV+ + + A Sbjct: 184 DLKPENILL---DEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA 240 Query: 536 DLWSVGIILYQLVTGSPPFNG 598 D WS G+++++++TGS PF G Sbjct: 241 DWWSFGVLMFEMLTGSLPFQG 261 Score = 126 bits (317), Expect = 4e-29 Identities = 78/196 (39%), Positives = 108/196 (55%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H A TE AVK I + E++IL R HPNII L D Sbjct: 422 GVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPS------EEIEILLRYGQHPNIITLKDV 475 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +YL++E RGG+L +LR + E A + + + L VVHRDLKP Sbjct: 476 YDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKP 535 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQP-SGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL +G+ +++ DFGFAK L+ +GL T C + ++APEV++ Q YDA D+W Sbjct: 536 SNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIW 595 Query: 545 SVGIILYQLVTGSPPF 592 S+GI+LY ++ G PF Sbjct: 596 SLGILLYTMLAGFTPF 611
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 127 bits (320), Expect = 2e-29 Identities = 71/200 (35%), Positives = 114/200 (57%), Gaps = 3/200 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G+++ V+ + + G EVA+K I + A + + +EV I ++ HP+I+ L++ Sbjct: 19 GKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNY 78 Query: 191 IRDGGRIYLILEYCRGGDLYAYLL-RHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 D +YL+LE C G++ YL R K E A+HF+ Q+ G+ L ++HRDL Sbjct: 79 FEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLT 138 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 N+LL N +KIADFG A L+ P TLCG+P Y++PE+ + ++D+W Sbjct: 139 LSNLLLTRNMN---IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVW 195 Query: 545 SVGIILYQLVTGSPPFNGDS 604 S+G + Y L+ G PPF+ D+ Sbjct: 196 SLGCMFYTLLIGRPPFDTDT 215
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 127 bits (320), Expect = 2e-29 Identities = 78/202 (38%), Positives = 114/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G++S + G E AVK LS +L ++ EV LR +HPN++ LH+ Sbjct: 418 GQGSFSVCRRCRQRQSGQEFAVKI-----LSRRLEENTQREVAALRLCQSHPNVVNLHEV 472 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRE-SNVVHRDLK 367 + D YL+LE RGG+L ++ + + E+ A +R L + + E + VVHRDLK Sbjct: 473 LHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQPSGLAE---TLCGSPLYMAPEVMQAQKYDAKAD 538 P+NIL + + +KI DFGFA+ L+P AE T C + Y APE++ Q YD D Sbjct: 533 PENILYADDTPGAPVKIIDFGFAR-LRPQSPAEPMQTPCFTLQYAAPELLAQQGYDESCD 591 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 LWS+G+ILY +++G PF G S Sbjct: 592 LWSLGVILYMMLSGQVPFQGAS 613 Score = 96.7 bits (239), Expect = 5e-20 Identities = 62/203 (30%), Positives = 114/203 (56%), Gaps = 10/203 (4%) Frame = +2 Query: 14 GSGAYSQVWL----GKHVARGTEVAVKEIAMDRL--SAKLRDSLLSEVDILRRITH-PNI 172 G+GAY +V+L G H A G A+K + L AK ++ +E +L + P + Sbjct: 40 GTGAYGKVFLVRKTGGHDA-GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFL 98 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 + LH + + +++LIL+Y GG+++ +L + + E + + ++ L+ L + ++ Sbjct: 99 VTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGII 158 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFAK--FLQPSGLAETLCGSPLYMAPEVMQAQKYD 526 +RDLK +N+LL S + + DFG +K + + CG+ YMAPE+++++ Sbjct: 159 YRDLKLENVLLDSEGH---IVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGH 215 Query: 527 AKA-DLWSVGIILYQLVTGSPPF 592 KA D WS+GI+L++L+TG+ PF Sbjct: 216 GKAVDWWSLGILLFELLTGASPF 238
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 127 bits (320), Expect = 2e-29 Identities = 77/206 (37%), Positives = 116/206 (56%), Gaps = 13/206 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVK--EIAMDRLSAK----LRDSLLSEVDILRRIT-HPNI 172 G G S V H A G E AVK E++ +RLS + +RD+ E+ ILR++ HP+I Sbjct: 31 GRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHI 90 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 I L DS ++L+ + R G+L+ YL + E + +R L + L +N+V Sbjct: 91 ITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIV 150 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQK---- 520 HRDLKP+NILL N ++++DFGF+ L+ LCG+P Y+APE+++ Sbjct: 151 HRDLKPENILLDDN---MQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETH 207 Query: 521 --YDAKADLWSVGIILYQLVTGSPPF 592 Y + DLW+ G+IL+ L+ GSPPF Sbjct: 208 PGYGKEVDLWACGVILFTLLAGSPPF 233
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 127 bits (320), Expect = 2e-29 Identities = 70/198 (35%), Positives = 113/198 (57%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAK-LRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V+L + VA+K + + + L L EV+I + H NI+ L++ Sbjct: 23 GRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNY 82 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D RIYLILEY GG+LY L RH+++ + I++L+ L E V+HRD+KP Sbjct: 83 FYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKP 142 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL N +KI+DFG++ PS +T+CG+ Y+ PE++ + Y+ DLW + Sbjct: 143 ENLLLGLNGE---VKISDFGWSVH-TPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCI 198 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+L+ G PPF + Sbjct: 199 GVLCYELLVGKPPFESST 216
>NEK3_HUMAN (P51956) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) (HSPK 36) Length = 506 Score = 127 bits (320), Expect = 2e-29 Identities = 69/203 (33%), Positives = 114/203 (56%), Gaps = 3/203 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G G++ + L +H + A+KEI + + + ++S E +L ++ HPNI+A Sbjct: 8 RMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSR-KEAVLLAKMKHPNIVAFK 66 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKR--VPETVAKHFIRQLACGLQKLRESNVVHR 358 +S G +Y+++EYC GGDL + + K PE + ++ Q+ G+ + + V+HR Sbjct: 67 ESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHR 126 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKA 535 D+K +NI L N +K+ DFG A+ L P A T G+P Y+ PE+ + Y+ K+ Sbjct: 127 DIKSKNIFLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKS 183 Query: 536 DLWSVGIILYQLVTGSPPFNGDS 604 D+WS+G ILY+L T PF +S Sbjct: 184 DIWSLGCILYELCTLKHPFQANS 206
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 127 bits (319), Expect = 3e-29 Identities = 67/196 (34%), Positives = 114/196 (58%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR-DSLLSEVDILRRITHPNIIALHDS 190 G GA+ +V+ + A+K + D++ K + + +E DIL +I HP I+ L S Sbjct: 147 GQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPFIVQLKYS 206 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + R+YL+L++ GG L+ L E +A+ + ++ + L E ++HRDLKP Sbjct: 207 FQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKP 266 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NIL+ + + + DFG AK + + + ++CG+ YMAPE+++ + +D AD WSV Sbjct: 267 ENILMDVDGH---VMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSV 323 Query: 551 GIILYQLVTGSPPFNG 598 GI+LY+++TG PPF G Sbjct: 324 GILLYEMLTGKPPFLG 339
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 127 bits (318), Expect = 3e-29 Identities = 67/198 (33%), Positives = 108/198 (54%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G Y V+ AVK ++ +L R E+DI++ + HPN++ L ++ Sbjct: 125 GKGTYGCVYKATDKLLKISRAVKVVSKKKLKNIPR--FRQEIDIMKNLDHPNVVKLLETF 182 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 D +IYL++E C GG+L+ +++ ET A ++Q+ L L N+ HRD+KP+ Sbjct: 183 EDSNQIYLVMELCTGGELFDKIVKKGCFVETFASFIMKQIFSVLNYLHIRNICHRDIKPE 242 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGL-AETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N L S++KI DFG A + + +T G+P Y+AP+V+ Y+ K D+WS Sbjct: 243 NFLFYDMTPESLIKIIDFGLASYFTHNNYEMKTKAGTPYYVAPQVLTG-SYNYKCDMWSS 301 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y L+ G PPF G+S Sbjct: 302 GVLFYILLCGYPPFFGES 319
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 127 bits (318), Expect = 3e-29 Identities = 68/205 (33%), Positives = 118/205 (57%), Gaps = 5/205 (2%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA-KLRDSLLSEVDILRRITHPNIIAL 181 R G G +++V K+ VA+K + +++ +L + + E+ ++ + HPN++ L Sbjct: 24 RTIGEGTFAKVRFAKNTENDEPVAIKILDKEKVQKHRLVEQIRREICTMKLVKHPNVVRL 83 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 + + RI+++LEY GG+L+ + + R+ E A+ + +QL + V HRD Sbjct: 84 FEVMGSKARIFIVLEYVTGGELFEIIATNGRLKEEEARKYFQQLINAVDYCHSRGVYHRD 143 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKF---LQPSGLAETLCGSPLYMAPEVMQAQKYD-A 529 LK +N+LL ++ LK++DFG + ++ GL T CG+P Y+APEV++ + YD A Sbjct: 144 LKLENLLLDASGN---LKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDRGYDGA 200 Query: 530 KADLWSVGIILYQLVTGSPPFNGDS 604 AD+WS G+ILY L+ G PF D+ Sbjct: 201 AADIWSCGVILYVLLAGFLPFEDDN 225
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 127 bits (318), Expect = 3e-29 Identities = 65/165 (39%), Positives = 101/165 (61%), Gaps = 5/165 (3%) Frame = +2 Query: 125 LLSEVDILRRIT-----HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETV 289 L +E+ ++R+I HPN+I L+D D ++L+LE C GG+L+ +++ +R E Sbjct: 90 LTNEILVMRKIVENVSPHPNVIDLYDVYEDENGVHLVLELCSGGELFDRIVKQERYSEVG 149 Query: 290 AKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAET 469 A +RQ+A GL L SN+VHRDLKP+N L + N S LKI DFG + + + Sbjct: 150 AAAVVRQIAQGLAALHRSNIVHRDLKPENCLFLDNTVDSPLKIMDFGLSSVEEFTDPVVG 209 Query: 470 LCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNGDS 604 L GS Y++PE + + +K+D+W++G+ILY L++G PPF S Sbjct: 210 LFGSIDYVSPEALSQGQVTSKSDMWALGVILYILLSGYPPFIAQS 254
>KAPB_SCHPO (P40376) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 512 Score = 127 bits (318), Expect = 3e-29 Identities = 67/198 (33%), Positives = 116/198 (58%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L + A+K + ++ K + E IL R+ HP I L + Sbjct: 208 GTGSFGRVHLVQSNHNRLYYAIKVLEKKKIVDMKQIEHTCDERYILSRVQHPFITILWGT 267 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +++++++ GG+L++ L + R PE VAK + ++ L L + +V+RDLKP Sbjct: 268 FQDAKNLFMVMDFAEGGELFSLLRKCHRFPEKVAKFYAAEVILALDYLHHNQIVYRDLKP 327 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL + LKI DFGFAK + S TLCG+P Y+APE++ + Y+ AD WS+ Sbjct: 328 ENLLL---DRFGHLKIVDFGFAKRVSTSNCC-TLCGTPDYLAPEIISLKPYNKAADWWSL 383 Query: 551 GIILYQLVTGSPPFNGDS 604 GI++++++ G PPF ++ Sbjct: 384 GILIFEMLAGYPPFYSEN 401
>KAPCB_PIG (P05383) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 127 bits (318), Expect = 3e-29 Identities = 65/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEFS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 127 bits (318), Expect = 3e-29 Identities = 65/197 (32%), Positives = 116/197 (58%), Gaps = 1/197 (0%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIAL 181 R G+G++ +V L + G A+K + + K + E +L ++HP II + Sbjct: 92 RTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRM 151 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 + +D +++++++Y GG+L++ L + +R P VAK + ++ L+ L ++++RD Sbjct: 152 WGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRD 211 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 LKP+NILL N +KI DFGFAK++ + TLCG+P Y+APEV+ + Y+ D Sbjct: 212 LKPENILLDKNGH---IKITDFGFAKYV--PDVTYTLCGTPDYIAPEVVSTKPYNKSVDW 266 Query: 542 WSVGIILYQLVTGSPPF 592 WS G+++Y+++ G PF Sbjct: 267 WSFGVLIYEMLAGYTPF 283
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 127 bits (318), Expect = 3e-29 Identities = 72/194 (37%), Positives = 107/194 (55%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + V+L + +A+K + +L A + L EV+I + HPNI+ L+ Sbjct: 133 GKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYGY 192 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YLILEY G +Y L + + E +I +LA L V+HRD+KP Sbjct: 193 FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKP 252 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL SN LKIADFG++ PS TLCG+ Y PE+++ + +D K DLWS+ Sbjct: 253 ENLLLGSNGE---LKIADFGWSVH-APSSRRTTLCGTLDYQPPEMIEGRMHDEKVDLWSL 308 Query: 551 GIILYQLVTGSPPF 592 G++ Y+ + G PPF Sbjct: 309 GVLCYEFLVGMPPF 322
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 126 bits (317), Expect = 4e-29 Identities = 68/198 (34%), Positives = 108/198 (54%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G Y V+ + AVK ++ +L R E+DI++ + HPN+I L ++ Sbjct: 119 GKGTYGCVYKATDKLLKIQRAVKVVSKKKLKNIPR--FRQEIDIMKNLDHPNVIKLLETF 176 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 D +IYLI++ C GG+L+ +++ E A ++Q+ L L N+ HRD+KP+ Sbjct: 177 EDEEQIYLIMDLCTGGELFDKIIKKGSFVEMYASFIMKQIFSVLNYLHIRNICHRDIKPE 236 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSGL-AETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 N L + S++KI DFG A + +T G+P Y+AP+V+ YD K DLWS Sbjct: 237 NFLFYDKSTESLIKIIDFGLAAYFNDIDYEMKTKAGTPYYVAPQVLTG-CYDYKCDLWSA 295 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y ++ G PPF G+S Sbjct: 296 GVLFYIILCGYPPFYGES 313
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 126 bits (317), Expect = 4e-29 Identities = 71/198 (35%), Positives = 109/198 (55%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + V+L + +A+K + +L A + L EV+I + HPNI+ L+ Sbjct: 140 GKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGY 199 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D R+YLILEY G +Y L + + E +I +LA L V+HRD+KP Sbjct: 200 FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKP 259 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+LL S LKIADFG++ PS TLCG+ Y+ PE+++ + +D K DLWS+ Sbjct: 260 ENLLLGS---AGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSL 315 Query: 551 GIILYQLVTGSPPFNGDS 604 G++ Y+ + G PPF ++ Sbjct: 316 GVLCYEFLVGKPPFEANT 333
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1) (Ribosomal| protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 126 bits (317), Expect = 4e-29 Identities = 81/203 (39%), Positives = 109/203 (53%), Gaps = 4/203 (1%) Frame = +2 Query: 8 ADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALH 184 A G G+YS H E AVK I + E++IL R HPNII L Sbjct: 440 AIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPS------EEIEILLRYGQHPNIITLK 493 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 D DG +YL+ E RGG+L +LR K E A + + ++ L VVHRDL Sbjct: 494 DVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDL 553 Query: 365 KPQNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 KP NIL V +G ++I DFGFAK L+ +GL T C + ++APEV++ Q YD D Sbjct: 554 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 613 Query: 539 LWSVGIILYQLVTGSPPF-NGDS 604 +WS+G++LY ++ G PF NG S Sbjct: 614 IWSLGVLLYTMLAGCTPFANGPS 636 Score = 125 bits (315), Expect = 7e-29 Identities = 67/199 (33%), Positives = 117/199 (58%), Gaps = 4/199 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEI-AMDRLSAKLRDSLLSEV--DILRRITHPNIIALH 184 G G++ +V+L + + + + + + + K+RD + +++ DIL + HP ++ LH Sbjct: 87 GQGSFGKVFLVRKITPPDSNHLYAMKVLKKATLKVRDRVRTKIERDILADVNHPFVVKLH 146 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +LA GL L +++RDL Sbjct: 147 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 206 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ Q + AD Sbjct: 207 KPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADW 263 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS G+++++++TGS PF G Sbjct: 264 WSYGVLMFEMLTGSLPFQG 282
>PSK1_SCHPO (Q12706) Serine/threonine-protein kinase psk1 (EC 2.7.11.22)| Length = 436 Score = 126 bits (317), Expect = 4e-29 Identities = 70/199 (35%), Positives = 110/199 (55%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEI--AMDRLSAKLRDSLLSEVDILRRITHPNIIALHD 187 G G+Y +V L K G A K++ A L AK + +E IL + HP I L+ Sbjct: 98 GRGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRLYY 157 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 + +D R+YLIL+Y GG+L+++L + +PE V + +L L L + +V+RDLK Sbjct: 158 AFQDHDRLYLILQYAPGGELFSHLAEQRMLPEDVVAFYTAELTLALIHLHKLGIVYRDLK 217 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 P+N LL + + + DFG +K + + G+ Y APE++ Q YD D WS Sbjct: 218 PENCLL---DAEGHILLTDFGLSKVAENGADCRSFVGTEEYCAPEILLEQPYDHAVDWWS 274 Query: 548 VGIILYQLVTGSPPFNGDS 604 +GI+++ L+TGSPPF ++ Sbjct: 275 MGILIFDLLTGSPPFTANN 293
>IKKB_RAT (Q9QY78) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.1) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 757 Score = 126 bits (317), Expect = 4e-29 Identities = 69/202 (34%), Positives = 108/202 (53%), Gaps = 9/202 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHD-- 187 G+G + V + G ++A+K+ + LS K RD E+ I+RR+ HPN++A D Sbjct: 22 GTGGFGNVIRWHNQVTGEQIAIKQCRQE-LSPKNRDRWCLEIQIMRRLNHPNVVAARDVP 80 Query: 188 ----SIRDGGRIYLILEYCRGGDLYAYLLRHKR---VPETVAKHFIRQLACGLQKLRESN 346 ++ L +EYC+GGDL YL + + + E + +A L+ L E+ Sbjct: 81 EGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAILTLLSDIASALRYLHENR 140 Query: 347 VVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYD 526 ++HRDLKP+NI+L I KI D G+AK L L + G+ Y+APE+++ QKY Sbjct: 141 IIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT 200 Query: 527 AKADLWSVGIILYQLVTGSPPF 592 D WS G + ++ +TG PF Sbjct: 201 VTVDYWSFGTLAFECITGFRPF 222
>IKKB_MOUSE (O88351) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 757 Score = 126 bits (317), Expect = 4e-29 Identities = 69/202 (34%), Positives = 109/202 (53%), Gaps = 9/202 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHD-- 187 G+G + V + A G ++A+K+ + LS K R+ E+ I+RR+ HPN++A D Sbjct: 22 GTGGFGNVIRWHNQATGEQIAIKQCRQE-LSPKNRNRWCLEIQIMRRLNHPNVVAARDVP 80 Query: 188 ----SIRDGGRIYLILEYCRGGDLYAYLLRHKR---VPETVAKHFIRQLACGLQKLRESN 346 ++ L +EYC+GGDL YL + + + E + +A L+ L E+ Sbjct: 81 EGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENR 140 Query: 347 VVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYD 526 ++HRDLKP+NI+L I KI D G+AK L L + G+ Y+APE+++ QKY Sbjct: 141 IIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT 200 Query: 527 AKADLWSVGIILYQLVTGSPPF 592 D WS G + ++ +TG PF Sbjct: 201 VTVDYWSFGTLAFECITGFRPF 222
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 126 bits (317), Expect = 4e-29 Identities = 67/194 (34%), Positives = 114/194 (58%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G + +V L + A+K +AM + K + + +E +ILR I HP +I+L S Sbjct: 281 GTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWS 340 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+I +Y GG+L+ YL + + + ++ L+ L +V+RDLKP Sbjct: 341 TKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKP 400 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ N LKI DFGFAK L+ TLCG+P Y+APE++Q++ ++ D W++ Sbjct: 401 ENLLI---NRDGHLKITDFGFAKKLRDR--TWTLCGTPEYIAPEIIQSKGHNKAVDWWAL 455 Query: 551 GIILYQLVTGSPPF 592 G+++Y+++ G PPF Sbjct: 456 GVLIYEMLVGYPPF 469
>KAPCB_RAT (P68182) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 126 bits (317), Expect = 4e-29 Identities = 65/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPCB_MOUSE (P68181) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 126 bits (317), Expect = 4e-29 Identities = 65/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPCB_CRIGR (P68180) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 126 bits (317), Expect = 4e-29 Identities = 65/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L S Sbjct: 50 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYS 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 126 bits (316), Expect = 6e-29 Identities = 77/211 (36%), Positives = 120/211 (56%), Gaps = 15/211 (7%) Frame = +2 Query: 14 GSGAYSQVWLG--KHVARGT--------EVAVKEIAMDRLSAKLRDS--LLSEVDILRRI 157 G G + +V LG K+ + + +VA+K I D +S R + E++ L+ + Sbjct: 48 GEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKHL 107 Query: 158 THPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLR 337 +HPNI+ L + +++ I ++LEY GG+ Y Y+ + +R+ E A QL G+ + Sbjct: 108 SHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYIH 167 Query: 338 ESNVVHRDLKPQNILLVSNNGTSILKIADFGFA-KFLQPSGLAETLCGSPLYMAPE-VMQ 511 +VHRDLK +N+LL N L I DFGF +F + L +T CGSP Y APE V+ Sbjct: 168 SKGLVHRDLKLENLLLDKNEN---LVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVIS 224 Query: 512 AQKYDA-KADLWSVGIILYQLVTGSPPFNGD 601 A+ Y+A KAD+WS G+ILY ++ G P++ D Sbjct: 225 AEPYEARKADIWSCGVILYAILAGYLPWDDD 255
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 126 bits (316), Expect = 6e-29 Identities = 68/199 (34%), Positives = 115/199 (57%), Gaps = 2/199 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS-AKLRDSLLSEVDILRRITHPNIIALHDS 190 G G++ +V L H G +VA+K I L+ + ++ + E+ LR + HP+II L+D Sbjct: 62 GEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDV 121 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I+ I +++EY G +L+ Y+++ ++ E A+ F +Q+ ++ +VHRDLKP Sbjct: 122 IKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKP 180 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKADLWS 547 +N+LL + +KIADFG + + +T CGSP Y APEV+ + Y + D+WS Sbjct: 181 ENLLLDEHLN---VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWS 237 Query: 548 VGIILYQLVTGSPPFNGDS 604 G+ILY ++ PF+ +S Sbjct: 238 CGVILYVMLCRRLPFDDES 256
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 126 bits (316), Expect = 6e-29 Identities = 80/196 (40%), Positives = 110/196 (56%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H A E AVK I + RD E++IL R HPNII L D Sbjct: 429 GVGSYSVCKRCIHKATNMEFAVKIIDKSK-----RDPT-EEIEILLRYGQHPNIITLKDV 482 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +Y++ E +GG+L +LR K E A + + ++ L VVHRDLKP Sbjct: 483 YDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKP 542 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G ++I DFGFAK L+ +GL T C + ++APEV++ Q YDA D+W Sbjct: 543 SNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIW 602 Query: 545 SVGIILYQLVTGSPPF 592 S+G++LY ++TG PF Sbjct: 603 SLGVLLYTMLTGYTPF 618 Score = 123 bits (309), Expect = 4e-28 Identities = 69/200 (34%), Positives = 115/200 (57%), Gaps = 5/200 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEV----AVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIAL 181 G G++ +V+L K ++ G++ A+K + L + R E DIL + HP I+ L Sbjct: 75 GQGSFGKVFLVKKIS-GSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKL 133 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 H + + G++YLIL++ RGGDL+ L + E K ++ +LA L L +++RD Sbjct: 134 HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRD 193 Query: 362 LKPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ + + AD Sbjct: 194 LKPENILL---DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSAD 250 Query: 539 LWSVGIILYQLVTGSPPFNG 598 WS G+++++++TG+ PF G Sbjct: 251 WWSFGVLMFEMLTGTLPFQG 270
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 126 bits (316), Expect = 6e-29 Identities = 80/196 (40%), Positives = 110/196 (56%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H A E AVK I + RD E++IL R HPNII L D Sbjct: 429 GVGSYSVCKRCIHKATNMEFAVKIIDKSK-----RDPT-EEIEILLRYGQHPNIITLKDV 482 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +Y++ E +GG+L +LR K E A + + ++ L VVHRDLKP Sbjct: 483 YDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKP 542 Query: 371 QNILLVSNNGT-SILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G ++I DFGFAK L+ +GL T C + ++APEV++ Q YDA D+W Sbjct: 543 SNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIW 602 Query: 545 SVGIILYQLVTGSPPF 592 S+G++LY ++TG PF Sbjct: 603 SLGVLLYTMLTGYTPF 618 Score = 123 bits (309), Expect = 4e-28 Identities = 69/200 (34%), Positives = 115/200 (57%), Gaps = 5/200 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEV----AVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIAL 181 G G++ +V+L K ++ G++ A+K + L + R E DIL + HP I+ L Sbjct: 75 GQGSFGKVFLVKKIS-GSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKL 133 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 H + + G++YLIL++ RGGDL+ L + E K ++ +LA L L +++RD Sbjct: 134 HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRD 193 Query: 362 LKPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ + + AD Sbjct: 194 LKPENILL---DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSAD 250 Query: 539 LWSVGIILYQLVTGSPPFNG 598 WS G+++++++TG+ PF G Sbjct: 251 WWSFGVLMFEMLTGTLPFQG 270
>KAPB2_BOVIN (P24256) cAMP-dependent protein kinase, beta-2-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-2) Length = 397 Score = 125 bits (315), Expect = 7e-29 Identities = 64/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L + Sbjct: 97 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYA 156 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 157 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 216 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 217 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 271 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 272 GVLIYEMAAGYPPFFAD 288
>KAPCB_HUMAN (P22694) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 125 bits (315), Expect = 7e-29 Identities = 64/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L + Sbjct: 50 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYA 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>KAPB1_BOVIN (P05131) cAMP-dependent protein kinase, beta-1-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-1) Length = 350 Score = 125 bits (315), Expect = 7e-29 Identities = 64/197 (32%), Positives = 118/197 (59%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V L KH A A+K + ++ K + L+E IL+ + P ++ L + Sbjct: 50 GTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYA 109 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y+++EY GG+++++L R R E A+ + Q+ + L ++++RDLKP Sbjct: 110 FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 169 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N LL+ + G +++ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 170 EN-LLIDHQG--YIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 224 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 225 GVLIYEMAAGYPPFFAD 241
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 125 bits (315), Expect = 7e-29 Identities = 66/168 (39%), Positives = 100/168 (59%), Gaps = 7/168 (4%) Frame = +2 Query: 110 KLRDSLLSEVDILRRIT-HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPET 286 +LR++ L EVDIL++++ HPNII L D+ +L+ + + G+L+ YL + E Sbjct: 65 ELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEK 124 Query: 287 VAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAE 466 + +R L + L + N+VHRDLKP+NILL N +K+ DFGF+ LQP Sbjct: 125 ETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLQPGEKLR 181 Query: 467 TLCGSPLYMAPEVMQAQK------YDAKADLWSVGIILYQLVTGSPPF 592 +CG+P Y+APE++Q Y + D+WS G+I+Y L+ GSPPF Sbjct: 182 EVCGTPSYLAPEIIQCSMDDGHPGYGKEVDMWSTGVIMYTLLAGSPPF 229
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 125 bits (314), Expect = 1e-28 Identities = 75/207 (36%), Positives = 112/207 (54%), Gaps = 14/207 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA-------KLRDSLLSEVDILRRIT-HPN 169 G G S V H E AVK I + + +LR++ L EVDILR+++ HPN Sbjct: 26 GRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPN 85 Query: 170 IIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNV 349 II L D+ +L+ + + G+L+ YL + E + +R L + L + N+ Sbjct: 86 IIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNI 145 Query: 350 VHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQK--- 520 VHRDLKP+NILL N +K+ DFGF+ L+P +CG+P Y+APE+++ Sbjct: 146 VHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNED 202 Query: 521 ---YDAKADLWSVGIILYQLVTGSPPF 592 Y + D+WS G+I+Y L+ GSPPF Sbjct: 203 HPGYGKEVDMWSTGVIMYTLLAGSPPF 229
>KIN4_YEAST (Q01919) Serine/threonine-protein kinase KIN4 (EC 2.7.11.1)| Length = 800 Score = 125 bits (314), Expect = 1e-28 Identities = 76/206 (36%), Positives = 118/206 (57%), Gaps = 10/206 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGT-----EVAVKEIAMDRLS--AKLRDSLLSEVDILRRITHPNI 172 G G + +V LG A + +VA+K I D + A + E++ L+ +THPNI Sbjct: 53 GEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNI 112 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 I L + +++ I ++LE+ GG+ Y Y+ R +R+ E+ A QL G+ + +V Sbjct: 113 IYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLV 172 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFA-KFLQPSGLAETLCGSPLYMAPE-VMQAQKYD 526 HRDLK +N+LL + L I DFGF +F + + L +T CGSP Y APE V+ + Y+ Sbjct: 173 HRDLKLENLLLDKHEN---LVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYE 229 Query: 527 A-KADLWSVGIILYQLVTGSPPFNGD 601 A KAD+WS G+ILY ++ G P++ D Sbjct: 230 ARKADVWSCGVILYAMLAGYLPWDDD 255
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 125 bits (314), Expect = 1e-28 Identities = 68/182 (37%), Positives = 107/182 (58%), Gaps = 6/182 (3%) Frame = +2 Query: 65 TEVAVKEIAMDRLSAKLRDSLLS-EVDILRRIT-----HPNIIALHDSIRDGGRIYLILE 226 TE +K M ++S D+LL+ E+ ++RRI HPN+I L+D D ++L+LE Sbjct: 77 TETMMKFPTMRQVSVS--DALLTNEILVMRRIVENVSPHPNVIDLYDVYEDTNGVHLVLE 134 Query: 227 YCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTS 406 C GG+L+ ++ + ET A + Q+ GL+ + +N++HRDLKP+N L + S Sbjct: 135 LCSGGELFDRIVAQDKYSETEASTVVHQIVAGLEAIHRANIIHRDLKPENCLFLDVGKDS 194 Query: 407 ILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSP 586 LKI DFG + + + L GS Y++PE + K K+D+WS+G+ILY L++G P Sbjct: 195 SLKIMDFGLSSVEEFTDPVVGLFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSGYP 254 Query: 587 PF 592 PF Sbjct: 255 PF 256
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 125 bits (314), Expect = 1e-28 Identities = 66/195 (33%), Positives = 111/195 (56%), Gaps = 2/195 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRIT-HPNIIALHD 187 G G + +L G E A K IA +L + + + + E+ I+ + HPN+I++ Sbjct: 157 GQGQFGTTFLCVEKTTGKEFACKSIAKRKLLTDEDVEDVRREIQIMHHLAGHPNVISIKG 216 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 + D ++L++E C GG+L+ +++ E A R + ++ V+HRDLK Sbjct: 217 AYEDVVAVHLVMECCAGGELFDRIIQRGHYTERKAAELTRTIVGVVEACHSLGVMHRDLK 276 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 P+N L VS + S+LK DFG + F +P + + GSP Y+APEV++ ++Y +AD+WS Sbjct: 277 PENFLFVSKHEDSLLKTIDFGLSMFFKPDDVFTDVVGSPYYVAPEVLR-KRYGPEADVWS 335 Query: 548 VGIILYQLVTGSPPF 592 G+I+Y L++G PPF Sbjct: 336 AGVIVYILLSGVPPF 350
>IKKB_HUMAN (O14920) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 756 Score = 125 bits (314), Expect = 1e-28 Identities = 68/202 (33%), Positives = 109/202 (53%), Gaps = 9/202 (4%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHD-- 187 G+G + V + G ++A+K+ + LS + R+ E+ I+RR+THPN++A D Sbjct: 22 GTGGFGNVIRWHNQETGEQIAIKQCRQE-LSPRNRERWCLEIQIMRRLTHPNVVAARDVP 80 Query: 188 ----SIRDGGRIYLILEYCRGGDLYAYLLRHKR---VPETVAKHFIRQLACGLQKLRESN 346 ++ L +EYC+GGDL YL + + + E + +A L+ L E+ Sbjct: 81 EGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENR 140 Query: 347 VVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYD 526 ++HRDLKP+NI+L I KI D G+AK L L + G+ Y+APE+++ QKY Sbjct: 141 IIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT 200 Query: 527 AKADLWSVGIILYQLVTGSPPF 592 D WS G + ++ +TG PF Sbjct: 201 VTVDYWSFGTLAFECITGFRPF 222
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 125 bits (314), Expect = 1e-28 Identities = 66/168 (39%), Positives = 100/168 (59%), Gaps = 7/168 (4%) Frame = +2 Query: 110 KLRDSLLSEVDILRRIT-HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPET 286 +LR++ L EVDIL++++ HPNII L D+ +L+ + + G+L+ YL + E Sbjct: 65 ELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEK 124 Query: 287 VAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAE 466 + +R L + L + N+VHRDLKP+NILL N +K+ DFGF+ LQP Sbjct: 125 ETRKIMRALLEVVCTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLQPGEKLR 181 Query: 467 TLCGSPLYMAPEVMQAQK------YDAKADLWSVGIILYQLVTGSPPF 592 +CG+P Y+APE++Q Y + D+WS G+I+Y L+ GSPPF Sbjct: 182 EVCGTPSYLAPEIIQCSMDEGHPGYGKEVDMWSTGVIMYTLLAGSPPF 229
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 125 bits (313), Expect = 1e-28 Identities = 67/203 (33%), Positives = 116/203 (57%), Gaps = 7/203 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G +S+V+ + G VA+K++ + D + AK R + E+D+L+++ HPN+I + S Sbjct: 41 GRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYAS 100 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKR----VPE-TVAKHFIRQLACGLQKLRESNVVH 355 + + ++LE GDL + K+ +PE TV K+F+ QL L+ + V+H Sbjct: 101 FIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFV-QLCSALEHMHSRRVMH 159 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQP-SGLAETLCGSPLYMAPEVMQAQKYDAK 532 RD+KP N+ + + T ++K+ D G +F + A +L G+P YM+PE + Y+ K Sbjct: 160 RDIKPANVFITA---TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK 216 Query: 533 ADLWSVGIILYQLVTGSPPFNGD 601 +D+WS+G +LY++ PF GD Sbjct: 217 SDIWSLGCLLYEMAALQSPFYGD 239
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 125 bits (313), Expect = 1e-28 Identities = 70/202 (34%), Positives = 116/202 (57%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+G +++V L HV G VA+K + + L + L + +E+D L+ + H +I L+ + Sbjct: 18 GTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDL-PRVKTEIDALKSLRHQHICQLYHVL 76 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +I+++LEYC GG+L+ Y++ R+ E + RQ+ + + HRDLKP+ Sbjct: 77 ETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPE 136 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSG----LAETLCGSPLYMAPEVMQAQKY-DAKAD 538 N+L N+ LK+ DFG +P G +T CGS Y APE++Q + Y ++AD Sbjct: 137 NLLFDENHK---LKLIDFGLC--AKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEAD 191 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+GI+LY L+ G PF+ D+ Sbjct: 192 VWSMGILLYVLMCGFLPFDDDN 213
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 125 bits (313), Expect = 1e-28 Identities = 69/202 (34%), Positives = 118/202 (58%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA-KLRDSLLSEVDILRR---ITHPNIIAL 181 G G +++V + +H +VA+K + ++ A ++ + E+ ILR + HP+II + Sbjct: 21 GVGTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIKILRLFIDLIHPHIIRV 80 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 ++ I I++++EYC+ GDL Y+L +R+ E A+ +Q+ ++ + VVHRD Sbjct: 81 YEVIVTPKDIFVVMEYCQNGDLLDYILEKRRLQEDEARRTFQQIISAVEYCHRNKVVHRD 140 Query: 362 LKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKY-DAKAD 538 LKP+N+LL S +K+ADFG + + +T CGS Y APEV+ + Y + D Sbjct: 141 LKPENLLLDSKYN---VKLADFGLSNVMHDGHFLKTSCGSLNYAAPEVISGKLYAGPEID 197 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS G+ILY L+ G+ PF+ D+ Sbjct: 198 VWSCGVILYALLCGAVPFDDDN 219
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 124 bits (312), Expect = 2e-28 Identities = 67/203 (33%), Positives = 115/203 (56%), Gaps = 7/203 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G +S+V+ + G VA+K++ + D + AK R + E+D+L+++ HPN+I + S Sbjct: 41 GRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYAS 100 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKR----VPE-TVAKHFIRQLACGLQKLRESNVVH 355 + + ++LE GDL + K+ +PE TV K+F+ QL L + V+H Sbjct: 101 FIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFV-QLCSALDHMHSRRVMH 159 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQP-SGLAETLCGSPLYMAPEVMQAQKYDAK 532 RD+KP N+ + + T ++K+ D G +F + A +L G+P YM+PE + Y+ K Sbjct: 160 RDIKPANVFITA---TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK 216 Query: 533 ADLWSVGIILYQLVTGSPPFNGD 601 +D+WS+G +LY++ PF GD Sbjct: 217 SDIWSLGCLLYEMAALQSPFYGD 239
>NEK1_MOUSE (P51954) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) Length = 1203 Score = 124 bits (312), Expect = 2e-28 Identities = 64/191 (33%), Positives = 110/191 (57%), Gaps = 3/191 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++ + L K G +KEI + R+S K R EV +L + HPNI+ +S Sbjct: 11 GEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESF 70 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRV--PETVAKHFIRQLACGLQKLRESNVVHRDLK 367 + G +Y++++YC GGDL+ + K E + Q+ L+ + + ++HRD+K Sbjct: 71 EENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIK 130 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 QNI L + +GT +++ DFG A+ L + LA T G+P Y++PE+ + + Y+ K+D+W Sbjct: 131 SQNIFL-TKDGT--VQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIW 187 Query: 545 SVGIILYQLVT 577 ++G +LY+L T Sbjct: 188 ALGCVLYELCT 198
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (Protein kinase PKX1) Length = 358 Score = 124 bits (312), Expect = 2e-28 Identities = 66/198 (33%), Positives = 116/198 (58%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G + +V L K A+K +++ D + K + +E +L+ ++HP +I L + Sbjct: 56 GTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWT 115 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 D +Y+++EY GG+L++YL R T + ++ C ++ L +V+RDLKP Sbjct: 116 WHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKP 175 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NILL + +K+ DFGFAK L TLCG+P Y+APEV+Q++ + D W++ Sbjct: 176 ENILL---DRDGHIKLTDFGFAKKLVDR--TWTLCGTPEYLAPEVIQSKGHGRAVDWWAL 230 Query: 551 GIILYQLVTGSPPFNGDS 604 GI+++++++G PPF D+ Sbjct: 231 GILIFEMLSGFPPFFDDN 248
>SGK2_MOUSE (Q9QZS5) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 367 Score = 124 bits (312), Expect = 2e-28 Identities = 66/196 (33%), Positives = 113/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDIL-RRITHPNIIALHD 187 G G Y +V L K + G AVK + L K ++ +++E ++L + + HP ++ L Sbjct: 42 GKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNVRHPFLVGLRY 101 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R +R E A+ + ++A + L N+++RDLK Sbjct: 102 SFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNIIYRDLK 161 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL + + + DFG K ++P T CG+P Y+APEV++ + YD D W Sbjct: 162 PENILL---DCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWW 218 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 219 CLGAVLYEMLHGLPPF 234
>SGK2_HUMAN (Q9HBY8) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 427 Score = 124 bits (312), Expect = 2e-28 Identities = 66/196 (33%), Positives = 111/196 (56%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDS-LLSEVDIL-RRITHPNIIALHD 187 G G Y +V L K + G AVK + + K S +++E +L + + HP ++ L Sbjct: 102 GKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRY 161 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R +R E A+ + ++A + L N+++RDLK Sbjct: 162 SFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLK 221 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL + + + DFG K ++P T CG+P Y+APEV++ + YD D W Sbjct: 222 PENILL---DCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWW 278 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 279 CLGAVLYEMLHGLPPF 294
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 124 bits (311), Expect = 2e-28 Identities = 66/194 (34%), Positives = 111/194 (57%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR-DSLLSEVDILRRITHPNIIALHDS 190 G G++ +V K A+K + D + A+ + + SE IL+ I+HP I+ LH + Sbjct: 160 GKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSEKTILQCISHPFIVNLHYA 219 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + ++Y++L++ GG+L+ +L R R E K + ++ L L + ++V+RDLKP Sbjct: 220 FQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIVSALDHLHKQDIVYRDLKP 279 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NILL S + I DFG +K ++ + T CG+P Y+APEV+ + D WS+ Sbjct: 280 ENILLDSEGH---ICITDFGLSKKIETTDGTFTFCGTPEYLAPEVLNGHGHGCAVDWWSL 336 Query: 551 GIILYQLVTGSPPF 592 G +LY+++TG PPF Sbjct: 337 GTLLYEMLTGLPPF 350
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 124 bits (311), Expect = 2e-28 Identities = 68/199 (34%), Positives = 112/199 (56%), Gaps = 4/199 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA---RGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 G G++ +V+L + V G A+K + L + R E +IL I+HP I+ LH Sbjct: 111 GQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLH 170 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +L L+ L +V+RDL Sbjct: 171 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDL 230 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + + CG+ YMAPEV+ + + AD Sbjct: 231 KPENILL---DADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADF 287 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS+G+++++++TG PF G Sbjct: 288 WSLGVLMFEMLTGHLPFQG 306 Score = 102 bits (255), Expect = 7e-22 Identities = 71/197 (36%), Positives = 102/197 (51%), Gaps = 4/197 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPN-IIALHDS 190 G+GA+S V + A + AVK + A EVDIL R +H ++ L D Sbjct: 461 GNGAHSVVHKCQMKATRRKYAVKIVKKAVFDAT------EEVDILLRHSHHQFVVKLFDV 514 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRV-PETVAKHFIRQLACGLQKLRESNVVHRDLK 367 D IY+I E C GG+L L+ K + E + L +Q L V HRDL Sbjct: 515 YEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLT 574 Query: 368 PQNILLVSNNGT-SILKIADFGFAKFLQP-SGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 NIL +G S L+I DFGFAK + +G+ T C + ++APEV++ Q YD D+ Sbjct: 575 AANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDV 634 Query: 542 WSVGIILYQLVTGSPPF 592 WS+G++L+ ++TG PF Sbjct: 635 WSLGVLLHTMLTGCTPF 651
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 124 bits (311), Expect = 2e-28 Identities = 68/202 (33%), Positives = 112/202 (55%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLSEVDILRRITHPNIIAL 181 GSG ++ V + + G + A K I R + R + + EV IL+ I HPN+I L Sbjct: 20 GSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRHPNVITL 79 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 H+ + + LILE GG+L+ +L + + E A F++Q+ G+ L + H D Sbjct: 80 HEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILSGVYYLHSLQIAHFD 139 Query: 362 LKPQNILLVSNN-GTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ N +KI DFG A + + + G+P ++APE++ + +AD Sbjct: 140 LKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEAD 199 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF GD+ Sbjct: 200 MWSIGVITYILLSGASPFLGDT 221
>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase) Length = 944 Score = 124 bits (311), Expect = 2e-28 Identities = 69/200 (34%), Positives = 111/200 (55%), Gaps = 3/200 (1%) Frame = +2 Query: 5 RADGSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 R G GAY + L + + V KE+ + RLS K R L+E+ IL + H NIIA + Sbjct: 38 RVLGHGAYGEATLYRRTEDDSLVVWKEVGLARLSEKERRDALNEIVILSLLQHDNIIAYY 97 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKR--VPETVAKHFIRQLACGLQKLRESNVVHR 358 + D + + LEYC GG+L+ ++ K E ++ Q+ + + ++ ++HR Sbjct: 98 NHFLDSNTLLIELEYCNGGNLFDKIVHQKAQLFQEETVLWYLFQIVSAVSCIHKAGILHR 157 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAKFLQPS-GLAETLCGSPLYMAPEVMQAQKYDAKA 535 D+K NI L N ++K+ D+G AK L +AET G+ YM+PE+ Q KY K+ Sbjct: 158 DIKTLNIFLTKAN---LIKLGDYGLAKQLSSEYSMAETCVGTLYYMSPEICQGVKYSFKS 214 Query: 536 DLWSVGIILYQLVTGSPPFN 595 D+W+VG +LY+L+T + F+ Sbjct: 215 DIWAVGCVLYELLTLTRTFD 234
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 124 bits (311), Expect = 2e-28 Identities = 71/206 (34%), Positives = 117/206 (56%), Gaps = 13/206 (6%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLS------AKLRDSLLSEVDILRRITHPNII 175 GSG++ QV+LG + + G +AVK++ +D +S AKL D+L E+ +L+ ++H +I+ Sbjct: 401 GSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIV 460 Query: 176 ALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVH 355 S + + + LEY GG + L + ET+ K+FI+Q GL+ L +VH Sbjct: 461 QYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVH 520 Query: 356 RDLKPQNILLVSNNGTSILKIADFGFAKFLQ-------PSGLAETLCGSPLYMAPEVMQA 514 RD+K NI LV N G +KI+DFG +K L+ G + GS +MAPEV++ Sbjct: 521 RDIKGANI-LVDNKGK--IKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQ 577 Query: 515 QKYDAKADLWSVGIILYQLVTGSPPF 592 + K D+WS+G ++ +++T P+ Sbjct: 578 TMHTEKTDIWSLGCLVIEMLTSKHPY 603
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 124 bits (311), Expect = 2e-28 Identities = 69/199 (34%), Positives = 112/199 (56%), Gaps = 4/199 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA---RGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH 184 G G++ +V+L + + A+K + L + R E DIL + HP ++ LH Sbjct: 69 GQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLH 128 Query: 185 DSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDL 364 + + G++YLIL++ RGGDL+ L + E K ++ +LA GL L +++RDL Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 365 KPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 KP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ Q + AD Sbjct: 189 KPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHGADW 245 Query: 542 WSVGIILYQLVTGSPPFNG 598 WS G+++++++TGS PF G Sbjct: 246 WSYGVLMFEMLTGSLPFQG 264 Score = 121 bits (303), Expect = 2e-27 Identities = 77/196 (39%), Positives = 105/196 (53%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H E AVK I + E++ILRR HPNII L D Sbjct: 423 GVGSYSVCKRCVHKGTNMEYAVKVIDKSKRDPS------EEIEILRRYGQHPNIITLKDV 476 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + IYL+ E RGG+L +LR K E A + + ++ L VVHRDLKP Sbjct: 477 YEECNSIYLVTELMRGGELLDRILRQKFFSEREACSVLFTVCKTVEYLHSQGVVHRDLKP 536 Query: 371 QNILLVSNNG-TSILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL V +G ++I DFGF+K L+ +GL T C + ++APEV++ Q YD D+W Sbjct: 537 SNILYVDESGDPESIRICDFGFSKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 596 Query: 545 SVGIILYQLVTGSPPF 592 S+GI+LY ++ G PF Sbjct: 597 SLGILLYTMLAGYTPF 612
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 124 bits (310), Expect = 3e-28 Identities = 69/202 (34%), Positives = 114/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLSEVDILRRITHPNIIAL 181 GSG ++ V + + G E A K I + A R + + EV ILR++ H N+I L Sbjct: 30 GSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITL 89 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 HD + + LILE GG+L+ +L + + + E A FI+Q+ G+ L + H D Sbjct: 90 HDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFD 149 Query: 362 LKPQNILLVSNN-GTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ N +K+ DFG A ++ + + G+P ++APE++ + +AD Sbjct: 150 LKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEAD 209 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF GD+ Sbjct: 210 MWSIGVITYILLSGASPFLGDT 231
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 124 bits (310), Expect = 3e-28 Identities = 63/161 (39%), Positives = 97/161 (60%), Gaps = 5/161 (3%) Frame = +2 Query: 125 LLSEVDILRRIT-----HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETV 289 L +E+ ++RRI HPN+I L+D D ++L+LE C GG+L+ ++ + ET Sbjct: 88 LTNEILVMRRIVENVSPHPNVIDLYDVYEDTNGVHLVLELCSGGELFDRIVAQDKYSETE 147 Query: 290 AKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAET 469 A + Q+A GL+ + +N+VHRDLKP+N L + S LKI DFG + + + Sbjct: 148 AATVVHQIASGLEAVHRANIVHRDLKPENCLFLDVRKDSPLKIMDFGLSSVEEFTDPVVG 207 Query: 470 LCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPF 592 L GS Y++PE + K K+D+WS+G+ILY L++G PPF Sbjct: 208 LFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSGYPPF 248
>KRAC_DICDI (P54644) RAC-family serine/threonine-protein kinase homolog (EC| 2.7.11.1) Length = 444 Score = 123 bits (309), Expect = 4e-28 Identities = 68/196 (34%), Positives = 114/196 (58%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR-DSLLSEVDILRRITHPNIIALHDS 190 G G++ +V + G A+K ++ + + LSE +IL++I HP ++ L+ S Sbjct: 127 GKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVNLNYS 186 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + ++Y IL+Y GG+L+ +L + K+ E +++ ++ L+ L S V++RDLKP Sbjct: 187 FQTEDKLYFILDYVNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLHLSGVIYRDLKP 246 Query: 371 QNILLVSNNGTSILKIADFGFAK--FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 +N+LL +N G + + DFG K L P+ T CG+P Y+APEV+Q Y + D W Sbjct: 247 ENLLL-TNEGH--ICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGNGYGKQVDWW 303 Query: 545 SVGIILYQLVTGSPPF 592 S G +LY+++TG PPF Sbjct: 304 SFGSLLYEMLTGLPPF 319
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 123 bits (309), Expect = 4e-28 Identities = 66/182 (36%), Positives = 104/182 (57%), Gaps = 1/182 (0%) Frame = +2 Query: 62 GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSIRDGGRIYLILEYCRGG 241 G E A+K I + K + +EV ILRR+ HPNII L + + ++L++E +GG Sbjct: 417 GKEFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGG 475 Query: 242 DLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVS-NNGTSILKI 418 DL+ + + E + LA L+ L ++VHRD+KP+N+L+ +GT LK+ Sbjct: 476 DLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKL 535 Query: 419 ADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNG 598 DFG A ++ G T+CG+P Y+APE++ Y K D+W+ G+I Y L+ G PPF Sbjct: 536 GDFGLATVVE--GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRS 593 Query: 599 DS 604 ++ Sbjct: 594 EN 595
>NEK2_HUMAN (P51955) Serine/threonine-protein kinase Nek2 (EC 2.7.11.1)| (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) Length = 445 Score = 123 bits (309), Expect = 4e-28 Identities = 69/209 (33%), Positives = 116/209 (55%), Gaps = 12/209 (5%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+G+Y + + + G + KE+ ++ + L+SEV++LR + HPNI+ +D I Sbjct: 15 GTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRI 74 Query: 194 --RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFI----RQLACGLQKLRESN--- 346 R +Y+++EYC GGDL + + + + + + + F+ QL L++ + Sbjct: 75 IDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGG 134 Query: 347 --VVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQ 517 V+HRDLKP N+ L +G +K+ DFG A+ L + A+T G+P YM+PE M Sbjct: 135 HTVLHRDLKPANVFL---DGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRM 191 Query: 518 KYDAKADLWSVGIILYQLVTGSPPFNGDS 604 Y+ K+D+WS+G +LY+L PPF S Sbjct: 192 SYNEKSDIWSLGCLLYELCALMPPFTAFS 220
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 123 bits (309), Expect = 4e-28 Identities = 68/202 (33%), Positives = 112/202 (55%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR----DSLLSEVDILRRITHPNIIAL 181 GSG ++ V + + G + A K I R + R + + EV IL+ I HPN+I L Sbjct: 20 GSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITL 79 Query: 182 HDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRD 361 H+ + + LILE GG+L+ +L + + E A F++Q+ G+ L + H D Sbjct: 80 HEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFD 139 Query: 362 LKPQNILLVSNN-GTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKAD 538 LKP+NI+L+ N +KI DFG A + + + G+P ++APE++ + +AD Sbjct: 140 LKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEAD 199 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+G+I Y L++G+ PF GD+ Sbjct: 200 MWSIGVITYILLSGASPFLGDT 221
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 123 bits (308), Expect = 5e-28 Identities = 75/201 (37%), Positives = 109/201 (54%), Gaps = 4/201 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G++S + G E AVK LS +L + EV LR +HPN++ LH+ Sbjct: 418 GQGSFSVCRRCRQRQSGQEFAVKI-----LSRRLEANTQREVAALRLCQSHPNVVNLHEV 472 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRE-SNVVHRDLK 367 D YL+LE RGG+L ++ + + E+ A +R L + + E + VVHRDLK Sbjct: 473 HHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 368 PQNILLVSNNGTSILKIADFGFAKFL--QPSGLAETLCGSPLYMAPEVMQAQKYDAKADL 541 P+NIL + + +KI DFGFA+ P +T C + Y APE++ Q YD DL Sbjct: 533 PENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDL 592 Query: 542 WSVGIILYQLVTGSPPFNGDS 604 WS+G+ILY +++G PF G S Sbjct: 593 WSLGVILYMMLSGQVPFQGAS 613 Score = 96.7 bits (239), Expect = 5e-20 Identities = 62/203 (30%), Positives = 114/203 (56%), Gaps = 10/203 (4%) Frame = +2 Query: 14 GSGAYSQVWL----GKHVARGTEVAVKEIAMDRL--SAKLRDSLLSEVDILRRITH-PNI 172 G+GAY +V+L G H A G A+K + L AK ++ +E +L + P + Sbjct: 40 GTGAYGKVFLVRKAGGHDA-GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFL 98 Query: 173 IALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVV 352 + LH + + +++LIL+Y GG+++ +L + + E + + ++ L+ L + ++ Sbjct: 99 VTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGII 158 Query: 353 HRDLKPQNILLVSNNGTSILKIADFGFAK--FLQPSGLAETLCGSPLYMAPEVMQAQKYD 526 +RDLK +N+LL S + + DFG +K + + CG+ YMAPE+++++ Sbjct: 159 YRDLKLENVLLDSEGH---IVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGH 215 Query: 527 AKA-DLWSVGIILYQLVTGSPPF 592 KA D WS+GI+L++L+TG+ PF Sbjct: 216 GKAVDWWSLGILLFELLTGASPF 238
>SGK2_RAT (Q8R4U9) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) (Fragment) Length = 302 Score = 123 bits (308), Expect = 5e-28 Identities = 66/196 (33%), Positives = 111/196 (56%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDIL-RRITHPNIIALHD 187 G G Y +V L K + G AVK + L K + +++E ++L + + HP ++ L Sbjct: 25 GKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQSHIMAERNVLLKNVRHPFLVGLRY 84 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L+Y GG+L+ +L R R E A+ + ++A + L N+++RDLK Sbjct: 85 SFQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYTAEVASAIGYLHSLNIIYRDLK 144 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL + + + DFG K ++P T CG+P Y+APEV++ + YD D W Sbjct: 145 PENILL---DCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWW 201 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 202 CLGAVLYEMLHGLPPF 217
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 123 bits (308), Expect = 5e-28 Identities = 65/195 (33%), Positives = 106/195 (54%), Gaps = 2/195 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLR-DSLLSEVDILRRIT-HPNIIALHD 187 G G + +L + G E A K I +L K + + E+ I+ ++ H N++A+ D Sbjct: 86 GQGQFGTTYLCTEINTGCEYACKTIPKRKLITKEDVEDVRREIQIMHHLSGHKNVVAIKD 145 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 DG +++++E C GG+L+ + E A IR + + V+HRDLK Sbjct: 146 VYEDGQAVHIVMELCAGGELFDRIQEKGHYSERKAAELIRIIVSIVAMCHSLGVMHRDLK 205 Query: 368 PQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWS 547 P+N LL+ + +K DFG + F +P + L GSP Y+APEV+ ++Y ++D+WS Sbjct: 206 PENFLLLDKDDDLSIKAIDFGLSVFFKPGQVFTELVGSPYYVAPEVLH-KRYGPESDVWS 264 Query: 548 VGIILYQLVTGSPPF 592 G+ILY L++G PPF Sbjct: 265 AGVILYVLLSGVPPF 279
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 123 bits (308), Expect = 5e-28 Identities = 66/182 (36%), Positives = 104/182 (57%), Gaps = 1/182 (0%) Frame = +2 Query: 62 GTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSIRDGGRIYLILEYCRGG 241 G E A+K I + K + +EV ILRR+ HPNII L + + ++L++E +GG Sbjct: 416 GKEFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGG 474 Query: 242 DLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVS-NNGTSILKI 418 DL+ + + E + LA L+ L ++VHRD+KP+N+L+ +GT LK+ Sbjct: 475 DLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKL 534 Query: 419 ADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFNG 598 DFG A ++ G T+CG+P Y+APE++ Y K D+W+ G+I Y L+ G PPF Sbjct: 535 GDFGLATVVE--GPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRS 592 Query: 599 DS 604 ++ Sbjct: 593 EN 594
>KAPC_DROME (P12370) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 352 Score = 122 bits (307), Expect = 6e-28 Identities = 62/197 (31%), Positives = 116/197 (58%), Gaps = 1/197 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G++ +V + +H A+K + ++ K + L+E IL+ I P +++L Sbjct: 52 GTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYH 111 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y++LEY GG+++++L + R E ++ + Q+ + L ++++RDLKP Sbjct: 112 FKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKP 171 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L+ S LK+ DFGFAK + G TLCG+P Y+APE++ ++ Y+ D W++ Sbjct: 172 ENLLIDSQ---GYLKVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL 226 Query: 551 GIILYQLVTGSPPFNGD 601 G+++Y++ G PPF D Sbjct: 227 GVLVYEMAAGYPPFFAD 243
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 122 bits (307), Expect = 6e-28 Identities = 71/194 (36%), Positives = 112/194 (57%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 G GA S V+ K +GT+ K A+ L + ++ +E+ +L R++HPNII L + Sbjct: 49 GRGATSIVYRCKQ--KGTQ---KPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEI 103 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I L+LE GG+L+ ++ E A+ ++Q+ + L E+ +VHRDLKP Sbjct: 104 FETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKP 163 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L + + LKIADFG +K ++ L +T+CG+P Y APE+++ Y + D+WSV Sbjct: 164 ENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSV 223 Query: 551 GIILYQLVTGSPPF 592 GII Y L+ G PF Sbjct: 224 GIITYILLCGFEPF 237
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 122 bits (307), Expect = 6e-28 Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 8/205 (3%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G G++ V T+ A+K++ ++ + L EV+IL+ + H +II L Sbjct: 123 GKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVF 182 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 ++YL++E C G+L L R E + I+ LA + L +++VHRDLK + Sbjct: 183 ETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLE 242 Query: 374 NILLVS-----NNGTSI-LKIADFGFA--KFLQPSGLAETLCGSPLYMAPEVMQAQKYDA 529 NI++ S NN ++ +K+ DFG A K + + + CG+P+YMAPEV+ A Y Sbjct: 243 NIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQ 302 Query: 530 KADLWSVGIILYQLVTGSPPFNGDS 604 + D+WS+G+++Y L+ G PPF S Sbjct: 303 QCDIWSIGVVMYMLLRGEPPFLASS 327
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 122 bits (307), Expect = 6e-28 Identities = 71/198 (35%), Positives = 115/198 (58%), Gaps = 4/198 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G GAY +V L + VAVK + M R +A +++ E+ I R ++H NI+ + Sbjct: 16 GEGAYGEVQLAVNRKTEEAVAVKIVDMTR-AADCPENIKKEICINRMLSHTNIVRFYGHR 74 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 R+G YL LEYCRGG+L+ + +PE A+ F +QL G++ L + HRD+KP+ Sbjct: 75 REGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGITHRDIKPE 134 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSG---LAETLCGSPLYMAPEVMQAQKYDA-KADL 541 N+LL + LKI+DFG A + +G L +CG+ Y+APE+++++ + A D+ Sbjct: 135 NLLLDERDQ---LKISDFGLATVFRHNGKERLLNKMCGTLPYVAPELIKSRAFHADPVDV 191 Query: 542 WSVGIILYQLVTGSPPFN 595 WS GI+L ++ G P++ Sbjct: 192 WSCGIVLTAMLAGELPWD 209
>SGK3_MOUSE (Q9ERE3) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Cytokine independent survival kinase) Length = 496 Score = 122 bits (307), Expect = 6e-28 Identities = 67/196 (34%), Positives = 112/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDIL-RRITHPNIIALHD 187 G G++ +V L K G AVK + L+ K + +++E ++L + + HP ++ LH Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L++ GG+L+ +L R + PE A+ + ++A L L +V+RDLK Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLK 288 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL + + + DFG K + S T CG+P Y+APEV++ Q YD D W Sbjct: 289 PENILL---DSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWW 345 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 346 CLGAVLYEMLYGLPPF 361
>SGK3_HUMAN (Q96BR1) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) Length = 496 Score = 122 bits (307), Expect = 6e-28 Identities = 67/196 (34%), Positives = 112/196 (57%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDR-LSAKLRDSLLSEVDIL-RRITHPNIIALHD 187 G G++ +V L K G AVK + L+ K + +++E ++L + + HP ++ LH Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLK 367 S + ++Y +L++ GG+L+ +L R + PE A+ + ++A L L +V+RDLK Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288 Query: 368 PQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 P+NILL + + + DFG K + S T CG+P Y+APEV++ Q YD D W Sbjct: 289 PENILL---DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWW 345 Query: 545 SVGIILYQLVTGSPPF 592 +G +LY+++ G PPF Sbjct: 346 CLGAVLYEMLYGLPPF 361
>NIMA_EMENI (P11837) G2-specific protein kinase nimA (EC 2.7.11.1) (Never in| mitosis) Length = 699 Score = 122 bits (306), Expect = 8e-28 Identities = 73/227 (32%), Positives = 114/227 (50%), Gaps = 33/227 (14%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALH--D 187 G G++ + K + G + KEI ++S K R+ L +E +IL + HPNI+A + + Sbjct: 18 GCGSFGIIRKVKRKSDGFILCRKEINYIKMSTKEREQLTAEFNILSSLRHPNIVAYYHRE 77 Query: 188 SIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFI----RQLACGLQ--------- 328 ++ +YL +EYC GGDL + KR + + F+ QL L Sbjct: 78 HLKASQDLYLYMEYCGGGDLSMVIKNLKRTNKYAEEDFVWRILSQLVTALYRCHYGTDPA 137 Query: 329 ------------------KLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPS 454 K + ++HRDLKP+NI L S+N +K+ DFG +K + Sbjct: 138 EVGSNLLGPAPKPSGLKGKQAQMTILHRDLKPENIFLGSDN---TVKLGDFGLSKLMHSH 194 Query: 455 GLAETLCGSPLYMAPEVMQAQKYDAKADLWSVGIILYQLVTGSPPFN 595 A T G+P YM+PE+ A+KY ++D+W+VG I+Y+L PPFN Sbjct: 195 DFASTYVGTPFYMSPEICAAEKYTLRSDIWAVGCIMYELCQREPPFN 241
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 122 bits (306), Expect = 8e-28 Identities = 64/168 (38%), Positives = 99/168 (58%), Gaps = 7/168 (4%) Frame = +2 Query: 110 KLRDSLLSEVDILRRIT-HPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPET 286 +LR++ L EVDILR+++ HPNII L D+ +L+ + + G+L+ YL + E Sbjct: 65 ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEK 124 Query: 287 VAKHFIRQLACGLQKLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAE 466 + +R L + L + N+VHRDLKP+NILL + +K+ DFGF+ L P Sbjct: 125 ETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMN---IKLTDFGFSCQLDPGEKLR 181 Query: 467 TLCGSPLYMAPEVMQAQK------YDAKADLWSVGIILYQLVTGSPPF 592 +CG+P Y+APE+++ Y + D+WS G+I+Y L+ GSPPF Sbjct: 182 EVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPF 229
>KPC1B_CAEEL (P34885) Protein kinase C-like 1B (EC 2.7.11.13) (PKC1B)| Length = 707 Score = 122 bits (305), Expect = 1e-27 Identities = 64/203 (31%), Positives = 111/203 (54%), Gaps = 6/203 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRIT-----HPNIIA 178 G G++ +V L + A+K + D + ++D + +RI HP + A Sbjct: 385 GKGSFGKVMLAERKGTDEVYAIKILKKDVI---VQDDDVECTMCEKRILSLAAKHPFLTA 441 Query: 179 LHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHR 358 LH S + R++ ++EY GGDL + R ++ E+ A+ + ++ C LQ L ++V++R Sbjct: 442 LHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYR 501 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA 535 DLK NILL + ++ADFG K + L T CG+P Y+APE++Q +Y Sbjct: 502 DLKLDNILL---DAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSV 558 Query: 536 DLWSVGIILYQLVTGSPPFNGDS 604 D W++G+++Y+++ G PPF D+ Sbjct: 559 DWWALGVLMYEMMAGQPPFEADN 581
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 122 bits (305), Expect = 1e-27 Identities = 69/201 (34%), Positives = 118/201 (58%), Gaps = 6/201 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVA---RGTEVAVKEIAMDRLSAKLRDSLLSEV--DILRRITHPNIIA 178 G G++ +V+L + G A+K + + S K+RD + +++ DIL + HP I+ Sbjct: 80 GQGSFGKVFLVRKKTGPDAGQLYAMK--VLKKASLKVRDRVRTKMERDILVEVNHPFIVK 137 Query: 179 LHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHR 358 LH + + G++YLIL++ RGGD++ L + E K ++ +LA L L + +V+R Sbjct: 138 LHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYR 197 Query: 359 DLKPQNILLVSNNGTSILKIADFGFAK-FLQPSGLAETLCGSPLYMAPEVMQAQKYDAKA 535 DLKP+NILL + +K+ DFG +K + A + CG+ YMAPEV+ + + A Sbjct: 198 DLKPENILL---DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSA 254 Query: 536 DLWSVGIILYQLVTGSPPFNG 598 D WS G+++++++TG+ PF G Sbjct: 255 DWWSYGVLMFEMLTGTLPFQG 275 Score = 117 bits (292), Expect = 3e-26 Identities = 72/196 (36%), Positives = 105/196 (53%), Gaps = 3/196 (1%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRI-THPNIIALHDS 190 G G+YS H E AVK I + E++IL R HPNII L D Sbjct: 433 GVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS------EEIEILMRYGQHPNIITLKDV 486 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 DG +YL+ + +GG+L +L+ K E A + ++ + L VVHRDLKP Sbjct: 487 FDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKP 546 Query: 371 QNILLVSNNGTS-ILKIADFGFAKFLQ-PSGLAETLCGSPLYMAPEVMQAQKYDAKADLW 544 NIL + + ++ ++I DFGFAK L+ +GL T C + ++APEV+ Q YDA D+W Sbjct: 547 SNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIW 606 Query: 545 SVGIILYQLVTGSPPF 592 S+G++ Y ++ G PF Sbjct: 607 SLGVLFYTMLAGYTPF 622
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 122 bits (305), Expect = 1e-27 Identities = 67/202 (33%), Positives = 115/202 (56%), Gaps = 5/202 (2%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLLSEVDILRRITHPNIIALHDSI 193 G+G +++V L H+ G VA+K + + L + L + +E++ L+ + H +I L+ + Sbjct: 18 GTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL-PRIKTEIEALKNLRHQHICQLYHVL 76 Query: 194 RDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKPQ 373 +I+++LEYC GG+L+ Y++ R+ E + RQ+ + + HRDLKP+ Sbjct: 77 ETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPE 136 Query: 374 NILLVSNNGTSILKIADFGFAKFLQPSG----LAETLCGSPLYMAPEVMQAQKY-DAKAD 538 N+L + LK+ DFG +P G +T CGS Y APE++Q + Y ++AD Sbjct: 137 NLLFDEYHK---LKLIDFGLC--AKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEAD 191 Query: 539 LWSVGIILYQLVTGSPPFNGDS 604 +WS+GI+LY L+ G PF+ D+ Sbjct: 192 VWSMGILLYVLMCGFLPFDDDN 213
>CHK2_CAEEL (Q9U1Y5) Serine/threonine-protein kinase chk-2 (EC 2.7.11.1)| (Ce-cds-1) (Ce-chk-2) Length = 476 Score = 122 bits (305), Expect = 1e-27 Identities = 69/206 (33%), Positives = 117/206 (56%), Gaps = 12/206 (5%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEI------AMDRLSAKLRDSLLSEVDILRRITHPNII 175 G G + +V LG + + VA+K++ R AK RD + +EV+++++++HPNI+ Sbjct: 177 GKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRD-IRNEVEVMKKLSHPNIV 235 Query: 176 ALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKR----VPETVAKHFIRQLACGLQKLRES 343 A++D I Y+++EY GG+ ++ ++ K + E++ K+F QL + L Sbjct: 236 AIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSV 295 Query: 344 NVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVM--QAQ 517 + HRD+KP+NIL ILK+ DFG AK +T CG+P Y APE++ + Sbjct: 296 GICHRDIKPENILCSDKAERCILKLTDFGMAK--NSVNRMKTRCGTPSYNAPEIVANEGV 353 Query: 518 KYDAKADLWSVGIILYQLVTGSPPFN 595 +Y K D+WS+G +L+ +G PPF+ Sbjct: 354 EYTPKVDIWSLGCVLFITFSGYPPFS 379
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 121 bits (304), Expect = 1e-27 Identities = 74/210 (35%), Positives = 108/210 (51%), Gaps = 16/210 (7%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSA---------------KLRDSLLSEVDIL 148 G G+ +V L ++ + G E AVK I+ + L + E+ I+ Sbjct: 26 GLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIM 85 Query: 149 RRITHPNIIALHDSIRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQ 328 + + HPN++ L+D +YL+LEY G+L+ L+ +PE A F RQ+ G+ Sbjct: 86 KLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVS 145 Query: 329 KLRESNVVHRDLKPQNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVM 508 +VHRDLKP+N+LL +KIADFG A L ET CGSP Y APE++ Sbjct: 146 YCHALGIVHRDLKPENLLLDHKYN---IKIADFGMAALETEGKLLETSCGSPHYAAPEIV 202 Query: 509 QAQKYDAKA-DLWSVGIILYQLVTGSPPFN 595 Y A D+WS G+IL+ L+TG PF+ Sbjct: 203 SGIPYQGFASDVWSCGVILFALLTGRLPFD 232
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 121 bits (304), Expect = 1e-27 Identities = 71/194 (36%), Positives = 111/194 (57%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 G GA S V+ K +GT+ K A+ L + ++ +E+ +L R++HPNII L + Sbjct: 49 GRGATSIVYRCKQ--KGTQ---KPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEI 103 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I L+LE GG+L+ ++ E A ++Q+ + L E+ +VHRDLKP Sbjct: 104 FETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKP 163 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L + + LKIADFG +K ++ L +T+CG+P Y APE+++ Y + D+WSV Sbjct: 164 ENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSV 223 Query: 551 GIILYQLVTGSPPF 592 GII Y L+ G PF Sbjct: 224 GIITYILLCGFEPF 237
>KGP2_HUMAN (Q13237) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 121 bits (304), Expect = 1e-27 Identities = 66/196 (33%), Positives = 108/196 (55%), Gaps = 1/196 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRL-SAKLRDSLLSEVDILRRITHPNIIALHDS 190 G G + +V L K A+K I + K ++ + SE IL + P I+ L+ + Sbjct: 460 GVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRT 519 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 +D +Y++LE C GG+L++ L E +K + + L +++RDLKP Sbjct: 520 FKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N++L + LK+ DFGFAK + T CG+P Y+APEV+ + +D D WS+ Sbjct: 580 ENLIL---DAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSL 636 Query: 551 GIILYQLVTGSPPFNG 598 GI++Y+L+TG+PPF+G Sbjct: 637 GILVYELLTGNPPFSG 652
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 121 bits (304), Expect = 1e-27 Identities = 71/194 (36%), Positives = 111/194 (57%), Gaps = 1/194 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAMDRLSAKLRDSLL-SEVDILRRITHPNIIALHDS 190 G GA S V+ K +GT+ K A+ L + ++ +E+ +L R++HPNII L + Sbjct: 53 GRGATSIVYRCKQ--KGTQ---KPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEI 107 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 I L+LE GG+L+ ++ E A ++Q+ + L E+ +VHRDLKP Sbjct: 108 FETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKP 167 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +N+L + + LKIADFG +K ++ L +T+CG+P Y APE+++ Y + D+WSV Sbjct: 168 ENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSV 227 Query: 551 GIILYQLVTGSPPF 592 GII Y L+ G PF Sbjct: 228 GIITYILLCGFEPF 241
>PRKY_HUMAN (O43930) Serine/threonine-protein kinase PRKY (EC 2.7.11.1)| Length = 277 Score = 121 bits (303), Expect = 2e-27 Identities = 64/198 (32%), Positives = 115/198 (58%), Gaps = 1/198 (0%) Frame = +2 Query: 14 GSGAYSQVWLGKHVARGTEVAVKEIAM-DRLSAKLRDSLLSEVDILRRITHPNIIALHDS 190 G+G + +V L K A+K +++ D + K + +E +L+ ++HP +I L + Sbjct: 56 GTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWT 115 Query: 191 IRDGGRIYLILEYCRGGDLYAYLLRHKRVPETVAKHFIRQLACGLQKLRESNVVHRDLKP 370 + +Y+++EY GG+L++YL T + ++ C ++ L +V+RDLKP Sbjct: 116 WHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKP 175 Query: 371 QNILLVSNNGTSILKIADFGFAKFLQPSGLAETLCGSPLYMAPEVMQAQKYDAKADLWSV 550 +NILL + +K+ DFGFAK L TLCG+P Y+APEV+Q++ + D W++ Sbjct: 176 ENILL---DRDGHIKLTDFGFAKKLVDR--TWTLCGTPEYLAPEVIQSKGHGRAVDWWAL 230 Query: 551 GIILYQLVTGSPPFNGDS 604 GI+++++++G PPF D+ Sbjct: 231 GILIFEMLSGFPPFFDDN 248 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 77,810,097 Number of Sequences: 219361 Number of extensions: 1492035 Number of successful extensions: 9331 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5726 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6069 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5367617986 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
