ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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更新日：2016年5月1日

Clone Information

BLAST Search Result

Clone Name baal37j23
Clone Library Name barley_pub
No. Definition Score
(bits)		 E
Value
1ISPH_SYNEL (Q8DK29) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 248 1e-65
2ISPH_SYNP6 (Q5N249) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 241 2e-63
3ISPH_ANASP (P58674) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 232 1e-60
4ISPH_SYNY3 (Q55643) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 223 5e-58
5ISPH_PROMA (Q7VDS2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 212 1e-54
6ISPH_PROMP (Q7V329) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 210 4e-54
7ISPH_GLOVI (Q7NG74) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 206 8e-53
8ISPH_SYNPX (Q7U9K4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 205 1e-52
9ISPH_PROMM (Q7V4T7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 204 2e-52
10ISPH_THETN (Q8RA76) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 75 2e-13
11ISPH_CLOPE (P58675) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 75 2e-13
12ISPH_VIBVY (Q7MNM5) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 75 3e-13
13ISPH_VIBVU (Q8DET0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 75 3e-13
14ISPH_VIBCH (Q9KU44) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 72 2e-12
15ISPH_XYLFT (P65194) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 70 7e-12
16ISPH_XYLFA (P65193) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 70 7e-12
17ISPH_BORPA (Q7W9B4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 70 7e-12
18ISPH_BORBR (Q7WHF2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 70 7e-12
19ISPH_BORPE (Q7VYS2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 70 7e-12
20ISPH1_RHOPA (Q6N3G0) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 70 9e-12
21ISPH_CLOAB (Q97I09) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 69 1e-11
22ISPH2_BURPS (Q9ZFL0) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 69 1e-11
23ISPH1_BURMA (Q629Z7) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 69 1e-11
24ISPH_GEOSL (Q749Y8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 69 2e-11
25ISPH_DESPS (Q6AL80) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 69 2e-11
26ISPH_ZYMMO (Q5NP61) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 68 3e-11
27ISPH_AZOSE (Q5P224) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 68 3e-11
28ISPH_VIBPA (Q87S87) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 67 4e-11
29ISPH_CHRVO (Q7NS59) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 67 8e-11
30ISPH_RALSO (P58677) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 66 1e-10
31ISPH2_BRAJA (Q89QW7) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 65 2e-10
32ISPH_XANCP (Q8PBG4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 65 2e-10
33ISPH2_BURMA (Q62HM8) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 65 3e-10
34ISPH1_BURPS (Q63WH0) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 65 3e-10
35ISPH_XANAC (Q8PN17) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 64 4e-10
36ISPH_ERWCT (Q6D0C6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 64 4e-10
37ISPH_XANOR (Q5H2D9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 64 6e-10
38ISPH_PSEAE (Q9HVM7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 64 6e-10
39ISPH_MANSM (Q65RQ4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 64 6e-10
40ISPH_BACHD (Q9KD37) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 64 6e-10
41ISPH_PHOPR (Q6LUK8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 63 8e-10
42ISPH_IDILO (Q5QZR7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 63 1e-09
43ISPH_WOLSU (Q7M8Y6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 1e-09
44ISPH_TREDE (Q73NQ6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 1e-09
45ISPH_VIBF1 (Q5E7N1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 1e-09
46ISPH_PASMU (P57960) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 1e-09
47ISPH_YERPS (Q66ES1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 2e-09
48ISPH_YERPE (P58680) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 2e-09
49ISPH_HELPY (P65185) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 2e-09
50ISPH_HELPJ (P65186) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 2e-09
51ISPH_STRAW (Q82IE8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 62 2e-09
52ISPH_HELHP (Q7VJV5) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 3e-09
53ISPH_PSESM (Q889E1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 3e-09
54ISPH_NITEU (Q82WM1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 3e-09
55ISPH_PHOLL (Q7N8W9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 4e-09
56ISPH_PSEPK (Q88Q89) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 4e-09
57ISPH_NEIMB (P65192) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 4e-09
58ISPH_NEIMA (P65191) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 4e-09
59ISPH_PARUW (Q6MC97) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 61 4e-09
60ISPH_ACIAD (Q9RBJ0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 5e-09
61ISPH_CLOTE (Q895G2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 7e-09
62ISPH_AQUAE (O67625) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 7e-09
63ISPH_NEIG1 (Q5FAF2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 7e-09
64ISPH_BUCAP (Q8K9Z4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 7e-09
65ISPH_STRCO (Q9FBM1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 7e-09
66ISPH_BACSU (P54473) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 60 9e-09
67ISPH2_MYCTU (P0A5I2) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 59 1e-08
68ISPH2_MYCBO (P0A5I3) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 59 1e-08
69ISPH_MYCPA (Q73WH6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 1e-08
70ISPH_BACLD (Q65H97) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 1e-08
71ISPH_CAMJR (Q5HUR4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 2e-08
72ISPH_CORGL (Q8NRM2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 2e-08
73ISPH_SYMTH (Q67QZ8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 2e-08
74ISPH_PROAC (Q6AA89) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 2e-08
75ISPH_LEIXX (Q6ADV0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 2e-08
76ISPH_FUSNN (Q8RI52) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 59 2e-08
77ISPH_WIGBR (Q8D2R2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
78ISPH_SHIFL (Q7UDT8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
79ISPH_SALTY (P58679) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
80ISPH_SALCH (Q57TL2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
81ISPH_ECOLI (P62623) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
82ISPH_ECOL6 (P62624) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
83ISPH_ECO57 (P62625) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
84ISPH_CAMJE (P94644) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
85ISPH_SHEON (Q8EBI7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
86ISPH_FRATT (Q5NGK4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 58 3e-08
87ISPH1_MYCTU (P0A5I0) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 57 6e-08
88ISPH1_MYCBO (P0A5I1) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 57 6e-08
89ISPH_SALTI (P58678) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 57 6e-08
90ISPH_SALPA (Q5PKI4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 57 6e-08
91ISPH_WOLTR (Q5GTN6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 56 1e-07
92ISPH_CHLTR (O84867) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 56 1e-07
93ISPH_BACSK (Q5WHC6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 56 1e-07
94ISPH_CORDI (Q6NI36) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 55 2e-07
95ISPH_HAEDU (Q7VPK4) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 55 2e-07
96ISPH_WOLPM (Q73FQ1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 55 2e-07
97ISPH_COREF (Q8FQP0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 55 2e-07
98ISPH_ANAMM (Q5PAE7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 55 3e-07
99ISPH_MYCLE (Q9X781) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 54 4e-07
100ISPH_METCA (Q607E5) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 54 5e-07
101ISPH_CAUCR (Q9A345) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 54 5e-07
102ISPH_NOCFA (Q5YQ94) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 53 1e-06
103ISPH_CHLCV (Q822D9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 52 1e-06
104ISPH_GLUOX (Q5FUH7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 52 2e-06
105ISPH_HAEIN (P44976) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 52 3e-06
106ISPH_DESVH (Q72G08) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 52 3e-06
107ISPH_EHRRG (Q5FFL5) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 51 3e-06
108ISPH_CHLAB (Q5L5D3) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 51 3e-06
109ISPH_LEPIN (Q8F3I3) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 51 4e-06
110ISPH_LEPIC (Q72S57) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 51 4e-06
111ISPH_EHRRW (Q5HB13) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 51 4e-06
112ISPH_TREPA (O83558) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 50 1e-05
113ISPH_CHLMU (Q9PL59) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 49 1e-05
114ISPH_BRUSU (Q8G257) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 49 2e-05
115ISPH_BRUME (Q8YFR1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 49 2e-05
116ISPH_BRUAB (Q57EP6) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 49 2e-05
117ISPH_GEOKA (Q5KX24) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 49 2e-05
118ISPH_RHOBA (Q7ULU1) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 49 2e-05
119ISPH_MYCPE (Q8EWR9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 48 3e-05
120ISPH1_BRAJA (Q89UU5) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 48 4e-05
121ISPH_LISMO (P58676) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 5e-05
122ISPH_BACHK (Q6HDN0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 5e-05
123ISPH_BACCZ (Q634Q0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 5e-05
124ISPH_BACC1 (Q730P8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 5e-05
125ISPH_BACAN (Q81LU9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 5e-05
126ISPH_AGRT5 (P58673) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 6e-05
127ISPH_CHLPN (Q9Z6P2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 6e-05
128ISPH_THEMA (Q9X1F7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 47 6e-05
129ISPH_BIFLO (Q8G4L8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 46 1e-04
130ISPH_THET8 (Q5SMC8) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 46 1e-04
131ISPH_TROWT (Q83MR9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 45 2e-04
132ISPH_TROW8 (Q83NB2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 45 2e-04
133ISPH_THET2 (Q72G65) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 45 2e-04
134ISPH_LISMF (Q71ZL9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 45 2e-04
135ISPH2_RHOPA (Q6N1Y1) 4-hydroxy-3-methylbut-2-enyl diphosphate re... 44 7e-04
136ISPH_BUCAI (P57247) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 43 9e-04
137ISPH_RHIME (Q92RG2) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 42 0.002
138ISPH_DEIRA (Q9RSG0) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 42 0.002
139ISPH_SILPO (Q5LNJ7) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 42 0.002
140ISPH_BARHE (Q6G4C5) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 42 0.002
141ISPH_BARQU (Q6G0C9) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 41 0.004
142ISPH_RHILO (Q985W3) 4-hydroxy-3-methylbut-2-enyl diphosphate red... 40 0.006
143LIFR_RAT (O70535) Leukemia inhibitory factor receptor precursor ... 35 0.32
144RL10_FUSNN (Q8RHI4) 50S ribosomal protein L10 34 0.54
145LIFR_MOUSE (P42703) Leukemia inhibitory factor receptor precurso... 33 0.71
146CH60_LACJO (Q9KJ23) 60 kDa chaperonin (Protein Cpn60) (groEL pro... 32 1.6
147RNP3_METMP (P60781) Ribonuclease P protein component 3 (EC 3.1.2... 32 2.7
148RPOL_PYRKO (Q5JE88) DNA-directed RNA polymerase subunit L (EC 2.... 31 4.6
149CH60_LACZE (O32847) 60 kDa chaperonin (Protein Cpn60) (groEL pro... 30 6.0
150KIF4A_CHICK (Q90640) Chromosome-associated kinesin KIF4A (Chromo... 30 7.8
151DMD_PIG (Q5GN48) Dystrophin 30 7.8 
>ISPH_SYNEL (Q8DK29) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 402

 Score =  248 bits (633), Expect = 1e-65
 Identities = 121/174 (69%), Positives = 144/174 (82%)
 Frame = +3

Query: 33  FLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFV 212
           F+ KF KA SPGFDPD DL +VGIANQTTMLKGETE+IGKL E+TM++K+G +  NEHF+
Sbjct: 223 FMAKFAKACSPGFDPDRDLVRVGIANQTTMLKGETEQIGKLFERTMIQKYGPDRLNEHFM 282

Query: 213 AFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQR 392
           +FNTICDATQERQDAM  LVKE +DL++VIGG+NSSNT+HLQEI    GIPSY IDS  R
Sbjct: 283 SFNTICDATQERQDAMLSLVKEPLDLMVVIGGYNSSNTTHLQEIAIEHGIPSYHIDSADR 342

Query: 393 IGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIK 554
           IGPGNRI +K  H     AENWLP+ PITIG+TSGASTPDKVVE+ L+K+F ++
Sbjct: 343 IGPGNRIEHKPLHQNPTVAENWLPDRPITIGITSGASTPDKVVEEVLNKIFALR 396
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>ISPH_SYNP6 (Q5N249) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 398

 Score =  241 bits (614), Expect = 2e-63
 Identities = 114/176 (64%), Positives = 145/176 (82%)
 Frame = +3

Query: 30  EFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHF 209
           EF+ +F KA S GFDPD DLE++GIANQTTMLK ETE IGKL E+T+++K+G +  N+HF
Sbjct: 222 EFMTRFGKACSAGFDPDRDLERIGIANQTTMLKSETEAIGKLFERTLLKKYGPQALNDHF 281

Query: 210 VAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQ 389
           +AFNTICDATQERQDAM+ LV+E +DLI+VIGG+NSSNT+HLQEI     IPS+ ID+ +
Sbjct: 282 LAFNTICDATQERQDAMFQLVEEPLDLIVVIGGFNSSNTTHLQEIAIERQIPSFHIDAAE 341

Query: 390 RIGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKR 557
           RIGPGNRI +K  H +L   E WLP GP+TIG+TSGASTPDKVVED + ++F+++R
Sbjct: 342 RIGPGNRIEHKPLHTDLTTTEPWLPAGPLTIGITSGASTPDKVVEDVIERLFDLQR 397
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>ISPH_ANASP (P58674) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 402

 Score =  232 bits (591), Expect = 1e-60
 Identities = 113/175 (64%), Positives = 139/175 (79%)
 Frame = +3

Query: 30  EFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHF 209
           EFL+KF KA S GFDPD DLE+VGIANQTTMLKGETE+IGKL E TM++K+G    N+HF
Sbjct: 222 EFLQKFAKACSAGFDPDRDLERVGIANQTTMLKGETEQIGKLFEHTMLQKYGPVELNQHF 281

Query: 210 VAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQ 389
            +FNTICDATQERQDAM  LV+E +DL++VIGG+NSSNT+ LQ+I +  G+PSY ID  +
Sbjct: 282 QSFNTICDATQERQDAMLELVQENLDLMIVIGGFNSSNTTQLQQISQERGLPSYHIDVVE 341

Query: 390 RIGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIK 554
           RI   N I ++  +GEL+  ENWLP G I +GVTSGASTPDKVVED + K+F +K
Sbjct: 342 RIKSINSIEHRQLNGELVTTENWLPAGKIVVGVTSGASTPDKVVEDVIEKIFALK 396
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>ISPH_SYNY3 (Q55643) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 379

 Score =  223 bits (568), Expect = 5e-58
 Identities = 114/184 (61%), Positives = 140/184 (76%), Gaps = 1/184 (0%)
 Frame = +3

Query: 30  EFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHF 209
           EFL+ F  A S GFDPD DL ++G+ANQTTMLK ETE IGKL EKT+++K+G    N HF
Sbjct: 195 EFLDYFANAHSAGFDPDQDLVRLGVANQTTMLKSETEMIGKLFEKTLLQKYGPIELNNHF 254

Query: 210 VAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQ 389
           ++FNTICDATQERQDAM+ LV+E + L++VIGG+NSSNT+HLQEI    GIPS  IDS  
Sbjct: 255 MSFNTICDATQERQDAMFDLVEEDLSLMVVIGGFNSSNTTHLQEIAVEHGIPSVHIDSGD 314

Query: 390 RIGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKR-QEV 566
           RIGPGNR+ +K    +L   E WLP G IT+GVTSGASTPDKVVE+ + K+  IK  Q V
Sbjct: 315 RIGPGNRVEHKPLGKDLEVLEPWLPAGKITVGVTSGASTPDKVVEEVMKKILAIKEAQPV 374

Query: 567 LQVA 578
           L++A
Sbjct: 375 LEIA 378
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>ISPH_PROMA (Q7VDS2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 405

 Score =  212 bits (539), Expect = 1e-54
 Identities = 104/187 (55%), Positives = 140/187 (74%), Gaps = 1/187 (0%)
 Frame = +3

Query: 12  GRN*XXEFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVE 191
           G+    +FL +F +A S GFDPD DL+++G+ANQTTMLK ETEEIG+L EKTM+RK+G  
Sbjct: 216 GKGNRDDFLRRFSRASSQGFDPDRDLKRLGVANQTTMLKSETEEIGRLFEKTMLRKYGPA 275

Query: 192 NANEHFVAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSY 371
             NEHF+AFNTICDAT+ERQDAM+ LV E +DL++VIGG+NSSNT+HLQEI    GI S+
Sbjct: 276 ELNEHFLAFNTICDATEERQDAMFSLVDEPLDLLVVIGGFNSSNTTHLQEIALAKGIRSF 335

Query: 372 WIDSEQRIGP-GNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            ID+ +RIG   N I +K    +L    N+LPEG I +G+TSGASTPD++VE  + K+  
Sbjct: 336 HIDTPERIGEIENTITHKPLGDDLRVESNFLPEGKINVGITSGASTPDRIVEHVIQKLIN 395

Query: 549 IKRQEVL 569
           +  ++++
Sbjct: 396 LSERKLM 402
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>ISPH_PROMP (Q7V329) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 398

 Score =  210 bits (534), Expect = 4e-54
 Identities = 104/183 (56%), Positives = 135/183 (73%), Gaps = 1/183 (0%)
 Frame = +3

Query: 12  GRN*XXEFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVE 191
           GR     FL KF +A S GFDPD DL++VG+ANQTTMLK ETEEIGK+ EKTM+ KFG E
Sbjct: 216 GRGNKNHFLNKFAQAFSNGFDPDKDLDRVGVANQTTMLKSETEEIGKVFEKTMLHKFGPE 275

Query: 192 NANEHFVAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSY 371
             N HF+AFNTICDAT+ERQDAM+ LV E +D+++VIGG+NSSNT+HLQEI     I S+
Sbjct: 276 KLNSHFLAFNTICDATEERQDAMFSLVDEDLDILVVIGGYNSSNTTHLQEIAINKNISSF 335

Query: 372 WIDSEQRIG-PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            ID+ +RI    N I +K    E++  +N++P+G I +G+TSGASTPDK+V D + K+  
Sbjct: 336 HIDTPERISVKENSILHKPLKSEMVLKKNFIPDGEIKVGITSGASTPDKIVADVIEKLIA 395

Query: 549 IKR 557
           I +
Sbjct: 396 ITK 398
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>ISPH_GLOVI (Q7NG74) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 417

 Score =  206 bits (523), Expect = 8e-53
 Identities = 100/175 (57%), Positives = 132/175 (75%), Gaps = 1/175 (0%)
 Frame = +3

Query: 33  FLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFV 212
           FL  F  A   GFDPD DL +VGIANQTTMLKGETE IGKL E+TMMR++G  N  +HF+
Sbjct: 217 FLAHFGMAACEGFDPDRDLVRVGIANQTTMLKGETERIGKLFERTMMRRYGPANLADHFM 276

Query: 213 AFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQR 392
           + +TICDATQERQDAM+ LV+E +DL++VIGG+NSSNT+HLQEI    G+PS+ ID   R
Sbjct: 277 SHDTICDATQERQDAMFKLVEEPLDLLVVIGGYNSSNTTHLQEIAVERGLPSFHIDGADR 336

Query: 393 IGPGNRIAYK-LNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIK 554
           +     I ++ L+   L+  +NWLP G +T+GVT+GASTPD+VV + + ++FE+K
Sbjct: 337 LVSAQFIEHRDLHSKSLVRTKNWLPAGEVTVGVTAGASTPDRVVAEVIARIFELK 391
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>ISPH_SYNPX (Q7U9K4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 399

 Score =  205 bits (521), Expect = 1e-52
 Identities = 101/178 (56%), Positives = 132/178 (74%), Gaps = 1/178 (0%)
 Frame = +3

Query: 12  GRN*XXEFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVE 191
           G+     F+++F  A SPGFDPD DL ++G+ANQTTMLK ETEEIG+L E+TM+ K+G  
Sbjct: 216 GKGDRDAFMQRFSAACSPGFDPDRDLSRLGVANQTTMLKSETEEIGRLFERTMLSKYGPA 275

Query: 192 NANEHFVAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSY 371
             N+HFVAFNTICDATQERQDAM+ LV E +DL++VIGG+NSSNT+HLQEI    GI S+
Sbjct: 276 ELNDHFVAFNTICDATQERQDAMFSLVDEPLDLMVVIGGFNSSNTTHLQEIALSRGIRSF 335

Query: 372 WIDSEQRI-GPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
            ID+  R+    N I +K  +  L    N+LP GP+T+G+TSGASTPD+ VE+ + K+
Sbjct: 336 HIDTPDRLDAQANAIEHKPLNENLRLESNFLPAGPVTVGITSGASTPDRAVEEVIEKL 393
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>ISPH_PROMM (Q7V4T7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 398

 Score =  204 bits (520), Expect = 2e-52
 Identities = 98/180 (54%), Positives = 135/180 (75%)
 Frame = +3

Query: 12  GRN*XXEFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVE 191
           G+     F+++F KA S  FDPD DL+++G+ANQTTMLK ETEEIG+L E+TM+RK+G  
Sbjct: 216 GQGDRAAFMKRFAKACSANFDPDQDLQRLGVANQTTMLKSETEEIGRLFERTMLRKYGPI 275

Query: 192 NANEHFVAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSY 371
             N+HF++FNTICDAT+ERQ AM+ LV E +DL++VIGG+NSSNT+HLQEI    GI S+
Sbjct: 276 ELNKHFLSFNTICDATEERQQAMFSLVDEPLDLLVVIGGFNSSNTTHLQEIAISRGIRSF 335

Query: 372 WIDSEQRIGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
            ID+ +RIG  N I +K    +L    N+LP G +++G+TSGASTPD+VVE  + K+ ++
Sbjct: 336 HIDTPERIGDNNSIQHKPLGEDLFIESNFLPAGSVSVGITSGASTPDRVVEHVIQKLIDL 395
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>ISPH_THETN (Q8RA76) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 288

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 53/158 (33%), Positives = 87/158 (55%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK    +QTT+++   E+I ++++             +  V FNTIC+ATQ+RQ+A   L
Sbjct: 157 EKACAVSQTTLIEKHWEDILEVLKSKA----------KELVYFNTICNATQKRQEAADAL 206

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            K KVD++ VIGG +SSNT  L++I E +   +Y I+        + I +++  G  I  
Sbjct: 207 SK-KVDVMFVIGGKHSSNTQKLRKICEKNCKNTYHIER------ADEITFEMLKGHDI-- 257

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQE 563
                     IG+T+GASTPD V+E+ + K+  +K ++
Sbjct: 258 ----------IGITAGASTPDYVIEEVIEKIKSLKGED 285
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>ISPH_CLOPE (P58675) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 282

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 56/153 (36%), Positives = 81/153 (52%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           KV + +QTT    E +E    V   ++R      A++  VAFNTIC AT  RQ ++  L 
Sbjct: 157 KVCVVSQTT----EKKETWNKVLNEIVR------ASKEIVAFNTICSATDVRQKSVQELS 206

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
           KE  DL+ VIGG NSSNT+ L EI +     SY I++ + +              L+E  
Sbjct: 207 KE-ADLVFVIGGKNSSNTTKLYEICKKECPKSYHIENVKELDE-----------SLLE-- 252

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
               E   TIG+T+GASTPD ++ + + K+ E+
Sbjct: 253 ---DESVKTIGITAGASTPDWIINEVISKIKEL 282
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>ISPH_VIBVY (Q7MNM5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 44/117 (37%), Positives = 66/117 (56%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L K+ VD+++V+G  NSSN++ L+E+ E  G P+Y  D  Q I P 
Sbjct: 198 ICYATQNRQDAVRELAKD-VDVVVVVGSKNSSNSTRLKELAEKLGTPAYLTDCPQDIEP- 255

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
                            W  +G + +GVT+GAS P+++V   L ++ E+  Q V +V
Sbjct: 256 ----------------QWF-DGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEV 295
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>ISPH_VIBVU (Q8DET0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 44/117 (37%), Positives = 66/117 (56%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L K+ VD+++V+G  NSSN++ L+E+ E  G P+Y  D  Q I P 
Sbjct: 198 ICYATQNRQDAVRELAKD-VDVVVVVGSKNSSNSTRLKELAEKLGTPAYLTDCPQDIEP- 255

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
                            W  +G + +GVT+GAS P+++V   L ++ E+  Q V +V
Sbjct: 256 ----------------QWF-DGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEV 295
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>ISPH_VIBCH (Q9KU44) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 50/164 (30%), Positives = 81/164 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D   +   +QTT+   ET ++   + +   +  G           + IC ATQ RQDA+ 
Sbjct: 159 DPSNLHYVSQTTLSVDETADVIDELRRVFPKIQGPRK--------DDICYATQNRQDAV- 209

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            ++ E+VD+++V+G  NSSN++ L+E+ E  G P Y ID  Q I P              
Sbjct: 210 RILAEQVDVMVVVGSKNSSNSTRLKELAEKLGTPGYLIDCPQDIDP-------------- 255

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
               W  +  + IGVT+GAS P+++V   L ++ E+    V +V
Sbjct: 256 ---EWFVDAQL-IGVTAGASAPEELVNQILDRIKELGATSVEEV 295
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>ISPH_XYLFT (P65194) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 50/147 (34%), Positives = 73/147 (49%)
 Frame = +3

Query: 111 QTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVDL 290
           QTT+   +T  I   + +      G +N        N IC ATQ RQDA+  L +E  DL
Sbjct: 168 QTTLSVDDTRNIIDALRQRFPTIQGPKN--------NDICYATQNRQDAVRELARE-CDL 218

Query: 291 ILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEG 470
           +LV+G  NSSN++ L E+ +  G+ SY IDS   I P                  W+ + 
Sbjct: 219 VLVVGSPNSSNSNRLSELAQREGVASYLIDSAAEIDPA-----------------WVID- 260

Query: 471 PITIGVTSGASTPDKVVEDTLHKVFEI 551
              IGVT+GAS P  +V+  L +++E+
Sbjct: 261 KHHIGVTAGASAPQVLVDGVLARLYEL 287
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>ISPH_XYLFA (P65193) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 50/147 (34%), Positives = 73/147 (49%)
 Frame = +3

Query: 111 QTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVDL 290
           QTT+   +T  I   + +      G +N        N IC ATQ RQDA+  L +E  DL
Sbjct: 168 QTTLSVDDTRNIIDALRQRFPTIQGPKN--------NDICYATQNRQDAVRELARE-CDL 218

Query: 291 ILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEG 470
           +LV+G  NSSN++ L E+ +  G+ SY IDS   I P                  W+ + 
Sbjct: 219 VLVVGSPNSSNSNRLSELAQREGVASYLIDSAAEIDPA-----------------WVID- 260

Query: 471 PITIGVTSGASTPDKVVEDTLHKVFEI 551
              IGVT+GAS P  +V+  L +++E+
Sbjct: 261 KHHIGVTAGASAPQVLVDGVLARLYEL 287
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>ISPH_BORPA (Q7W9B4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 326

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 42/109 (38%), Positives = 61/109 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L  E  DL+LV+G  NSSN++ L+E+ E  G+ +Y ID    I P 
Sbjct: 203 ICYATQNRQDAVKLLAPE-CDLVLVVGSTNSSNSNRLREVAERKGVAAYLIDGAHAIDPA 261

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                            WL +G  +IG+T+GAS P+ +V+  + +V E+
Sbjct: 262 -----------------WL-QGRRSIGITAGASAPEVLVQQVVERVREL 292
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>ISPH_BORBR (Q7WHF2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 326

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 42/109 (38%), Positives = 61/109 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L  E  DL+LV+G  NSSN++ L+E+ E  G+ +Y ID    I P 
Sbjct: 203 ICYATQNRQDAVKLLAPE-CDLVLVVGSTNSSNSNRLREVAERKGVAAYLIDGAHAIDPA 261

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                            WL +G  +IG+T+GAS P+ +V+  + +V E+
Sbjct: 262 -----------------WL-QGRRSIGITAGASAPEVLVQQVVERVREL 292
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>ISPH_BORPE (Q7VYS2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 325

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 42/109 (38%), Positives = 61/109 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L  E  DL+LV+G  NSSN++ L+E+ E  G+ +Y ID    I P 
Sbjct: 202 ICYATQNRQDAVKLLAPE-CDLVLVVGSTNSSNSNRLREVAERKGVAAYLIDGAHAIDPA 260

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                            WL +G  +IG+T+GAS P+ +V+  + +V E+
Sbjct: 261 -----------------WL-QGRRSIGITAGASAPEVLVQQVVERVREL 291
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>ISPH1_RHOPA (Q6N3G0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC|
           1.17.1.2)
          Length = 306

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 51/152 (33%), Positives = 75/152 (49%)
 Frame = +3

Query: 96  VGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVK 275
           V    QTT+   +T++I   + K      G +  +        IC ATQ RQ A+  + K
Sbjct: 156 VAYITQTTLSVDDTKDIIVALSKKFHDIEGPDTRD--------ICYATQNRQSAVRQMSK 207

Query: 276 EKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAEN 455
             VDLILV+G  NSSN++ L+EIG  +GIPSY I     + P                  
Sbjct: 208 -LVDLILVVGANNSSNSNRLREIGTEAGIPSYLIADGSELDPA----------------- 249

Query: 456 WLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
           WL +G   +G+T+GAS P+ +V+D +  +  I
Sbjct: 250 WL-DGKKAVGITAGASAPEVLVDDVIEALRRI 280
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>ISPH_CLOAB (Q97I09) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 642

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 55/152 (36%), Positives = 75/152 (49%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           KV I +QTT      E++ K           V+N     ++FNTIC+AT ERQ     L 
Sbjct: 158 KVCIVSQTTEKLENWEKVLK----------EVKNRAIEVISFNTICNATSERQKIAKDL- 206

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
             KVD ++VIGG  SSNT+ L EI + +                N   +  N GE+   E
Sbjct: 207 SNKVDFMVVIGGKQSSNTTKLYEICKSNC---------------NETIHVENSGEI--PE 249

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
           N L      IGVT+GASTPD ++E+ + K+ E
Sbjct: 250 NILKNKNCVIGVTAGASTPDWIIEEAISKMSE 281
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>ISPH2_BURPS (Q9ZFL0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (EC|
           1.17.1.2)
          Length = 313

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 49/146 (33%), Positives = 75/146 (51%)
 Frame = +3

Query: 96  VGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVK 275
           V    QTT+   +T  I + +++      G +  +        IC ATQ RQ A+  L  
Sbjct: 158 VAYVTQTTLSVDDTRGIIEALQRRFTDIVGPDTRD--------ICYATQNRQAAVREL-S 208

Query: 276 EKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAEN 455
           E+VD++LV+G  NSSN++ L+EIG  SG+PSY +                  G  + AE 
Sbjct: 209 EQVDVLLVVGATNSSNSNRLREIGTESGVPSYLVAD----------------GSEVRAE- 251

Query: 456 WLPEGPITIGVTSGASTPDKVVEDTL 533
           W      T+G+T+GAS P+++VED +
Sbjct: 252 WFANAR-TVGLTAGASAPEEMVEDVI 276
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>ISPH1_BURMA (Q629Z7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC|
           1.17.1.2)
          Length = 313

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 49/146 (33%), Positives = 75/146 (51%)
 Frame = +3

Query: 96  VGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVK 275
           V    QTT+   +T  I + +++      G +  +        IC ATQ RQ A+  L  
Sbjct: 158 VAYVTQTTLSVDDTRGIIEALQRRFTDIVGPDTRD--------ICYATQNRQAAVREL-S 208

Query: 276 EKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAEN 455
           E+VD++LV+G  NSSN++ L+EIG  SG+PSY +                  G  + AE 
Sbjct: 209 EQVDVLLVVGATNSSNSNRLREIGTESGVPSYLVAD----------------GSEVRAE- 251

Query: 456 WLPEGPITIGVTSGASTPDKVVEDTL 533
           W      T+G+T+GAS P+++VED +
Sbjct: 252 WFANAR-TVGLTAGASAPEEMVEDVI 276
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>ISPH_GEOSL (Q749Y8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 282

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 51/160 (31%), Positives = 81/160 (50%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           +++KVG+  QTT    ++ E  K V K  + K G          FNTICDAT  RQD   
Sbjct: 150 NMKKVGVVAQTT----QSFETLKNVVKECLLKGG------EIRVFNTICDATAVRQDEAK 199

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            L +E VD ++VIGG+NS+NT  L E+       +Y I++ Q +                
Sbjct: 200 ALARE-VDCMIVIGGFNSANTKRLAEVCSELQPRTYHIETAQELD--------------- 243

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQE 563
              +W  +G   +GVT+GASTP  ++++ + ++ E   ++
Sbjct: 244 --ASWF-QGVERVGVTAGASTPKWLIDEVIERIQEFDNKK 280
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>ISPH_DESPS (Q6AL80) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 313

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 50/162 (30%), Positives = 85/162 (52%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+    QTT+ + + E++  LV   + R+F +    +     + IC ATQ RQ+A+  L
Sbjct: 164 EKIAFVTQTTLAENDIEQV--LV--VLRRRFPLLQGPK-----SNICFATQNRQNAVRTL 214

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            +   DLILV+G  NSSN++ L+E+G  +G P+Y ID  + +                  
Sbjct: 215 AR-CTDLILVVGSKNSSNSNRLREVGTETGTPAYLIDDFKDL-----------------K 256

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
           E+W   G   +G+T+GAS P+ +VE  +  + +  R E+ ++
Sbjct: 257 ESWF-RGCERVGITAGASAPESLVEGVVVWLLKRGRYEITEM 297
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>ISPH_ZYMMO (Q5NP61) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 340

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 53/167 (31%), Positives = 79/167 (47%)
 Frame = +3

Query: 96  VGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVK 275
           V    QTT+   +T  +   + K      G + ++        IC ATQ RQ A+  L K
Sbjct: 159 VAFITQTTLSVDDTRSVIAALRKKFTDVIGPDTSD--------ICYATQNRQAAVRDLCK 210

Query: 276 EKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAEN 455
           +  DLILV+G  NSSN++ L+EIG   G+PSY I     I P                  
Sbjct: 211 QS-DLILVVGSPNSSNSNRLREIGLEEGLPSYLIADGSEIDP-----------------V 252

Query: 456 WLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA*IFSKI 596
           W  EG  T+G+T+GAS P+++V+  +  +  +    V Q+  +  KI
Sbjct: 253 WF-EGINTVGLTAGASAPEELVQSVITAIRALGPVTVEQLDGVEEKI 298
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>ISPH_AZOSE (Q5P224) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 312

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 40/114 (35%), Positives = 64/114 (56%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  +   +VD++ V+G  NSSN++ L+E+ EL G+P+Y +D+ + I P 
Sbjct: 196 ICYATQNRQDAVKFMAP-RVDVVFVVGSRNSSNSNRLREVAELLGVPAYLVDNAEGIEP- 253

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEV 566
                            WL E    +GVT+GAS P+ +V+  + ++ E+    V
Sbjct: 254 ----------------IWL-EDKKRVGVTAGASAPEVLVDAVVERLKELGASSV 290
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>ISPH_VIBPA (Q87S87) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 317

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 55/172 (31%), Positives = 83/172 (48%)
 Frame = +3

Query: 36  LEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVA 215
           +EK K  V    DP  DL  V   +QTT+   ET ++ + + +      G          
Sbjct: 150 VEKLKAIVK---DPS-DLHYV---SQTTLSVDETADVIEELRRVFPDIQGPRK------- 195

Query: 216 FNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRI 395
            + IC ATQ RQDA+  L  + VD+++V+G  NSSN++ L+E+ E  G P Y  D  + I
Sbjct: 196 -DDICYATQNRQDAVRELAGD-VDVMVVVGSKNSSNSTRLKELAEKLGTPGYLTDCPEDI 253

Query: 396 GPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
            P                  W  EG   +GVT+GAS P+++V   L ++ E+
Sbjct: 254 KP-----------------EWF-EGKTKVGVTAGASAPEELVNQILERIKEL 287
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>ISPH_CHRVO (Q7NS59) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 311

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 48/165 (29%), Positives = 83/165 (50%)
 Frame = +3

Query: 81  VDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAM 260
           V+ +++   +QTT+   ET +I   ++            N H    + IC ATQ RQDA+
Sbjct: 155 VNEDQLSYVSQTTLSVDETRDIIAALKARF--------PNIHSPKKDDICYATQNRQDAV 206

Query: 261 YHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGEL 440
             L+ ++ D+++V+G  NSSN++ L+E+  L G+ +Y +D+   + P             
Sbjct: 207 -KLLADQCDIVVVVGSPNSSNSNRLREVAALKGVDAYMVDNASLLEP------------- 252

Query: 441 IEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
                W   G   +GVT+GAS P+ +V+  + +   IK  +V QV
Sbjct: 253 ----EWF-AGKRRVGVTAGASAPEVLVQAVIDR---IKAFDVTQV 289
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>ISPH_RALSO (P58677) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 324

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 42/153 (27%), Positives = 77/153 (50%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D  ++    QTT+   ET+EI   ++              H      IC ATQ RQDA+ 
Sbjct: 170 DPARLAYVTQTTLSVDETQEIVAAIKARFPAV--------HEPKKQDICYATQNRQDAVK 221

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  + V++++V+G  NSSN++ L+E+ E  G+P+Y +D+ +++ P              
Sbjct: 222 FMAPQ-VEVVIVVGSPNSSNSNRLRELAEKLGVPAYMVDTPEQVRP-------------- 266

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
               WL  G   +G+T+GAS P+++ +  + ++
Sbjct: 267 ---EWL-AGKRRVGLTAGASAPEELAQSIVDRL 295
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>ISPH2_BRAJA (Q89QW7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (EC|
           1.17.1.2)
          Length = 308

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 42/109 (38%), Positives = 59/109 (54%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQ A+  L K  VD+ILV+G  NSSN++ L+EIG  +G+ SY I     + P 
Sbjct: 193 ICYATQNRQSAVRDLSK-LVDVILVVGAANSSNSNRLREIGTEAGVASYLIADGSELNP- 250

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                            WL +   T+GVT+GAS P+ +V+D +  +  I
Sbjct: 251 ----------------EWLKDAR-TVGVTAGASAPEVLVDDVIEAMRRI 282
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>ISPH_XANCP (Q8PBG4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 50/163 (30%), Positives = 78/163 (47%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           E +    QTT+   +T  I   +E   +R   ++         + IC ATQ RQDA+  L
Sbjct: 161 ESLAYTTQTTLSVDDTMGI---IEALRVRYPAMQGPKH-----DDICYATQNRQDAVRDL 212

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            ++  DL+LV+G  NSSN++ L E+    G+ SY ID+   I P                
Sbjct: 213 ARQ-CDLVLVVGSPNSSNSNRLSELARRDGVESYLIDNASEIDPA--------------- 256

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA 578
             W+  G   IG+T+GAS P  +V+  L ++ E+    V ++A
Sbjct: 257 --WI-VGKQHIGLTAGASAPQVLVDGVLARLRELGANGVSELA 296
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>ISPH2_BURMA (Q62HM8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (EC|
           1.17.1.2)
          Length = 326

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 46/156 (29%), Positives = 77/156 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D E+V +  QTT+   +  EI       +  KF      +       IC ATQ RQDA+ 
Sbjct: 169 DPERVALVTQTTLSVDDAAEI----IGALKAKFPAIREPKK----QDICYATQNRQDAVK 220

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  +  D+++V+G  NSSN+S L+E+ E  G+ +Y +D+ ++I P              
Sbjct: 221 FMAPQ-CDVVIVVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPA------------- 266

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
               W+  G   IGVT+GAS P+ + +  + ++ E+
Sbjct: 267 ----WV-AGKRRIGVTAGASAPEVLAQAVIARLREL 297
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>ISPH1_BURPS (Q63WH0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC|
           1.17.1.2)
          Length = 326

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 46/156 (29%), Positives = 77/156 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D E+V +  QTT+   +  EI       +  KF      +       IC ATQ RQDA+ 
Sbjct: 169 DPERVALVTQTTLSVDDAAEI----IGALKAKFPAIREPKK----QDICYATQNRQDAVK 220

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  +  D+++V+G  NSSN+S L+E+ E  G+ +Y +D+ ++I P              
Sbjct: 221 FMAPQ-CDVVIVVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPA------------- 266

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
               W+  G   IGVT+GAS P+ + +  + ++ E+
Sbjct: 267 ----WV-AGKRRIGVTAGASAPEVLAQAVIARLREL 297
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>ISPH_XANAC (Q8PN17) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 40/109 (36%), Positives = 58/109 (53%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L ++  DL+LV+G  NSSN++ L E+    G+ SY ID+   I P 
Sbjct: 198 ICYATQNRQDAVRDLARQ-CDLVLVVGSPNSSNSNRLSELARRDGVESYLIDNASEIDPA 256

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                            W+  G   IG+T+GAS P  +V+  L ++ E+
Sbjct: 257 -----------------WI-VGKQHIGLTAGASAPQVLVDGVLERLREL 287
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>ISPH_ERWCT (Q6D0C6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 39/109 (35%), Positives = 60/109 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ+A+ HL  +K D++ V+G  NSSN++ L E+ + +G  +Y IDS   I   
Sbjct: 196 ICYATTNRQEAVRHL-SDKADVVFVVGSKNSSNSNRLAELAQRAGKAAYLIDSADDI--- 251

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                          E+WL  G   +GVT+GAS PD +V+  + ++ E+
Sbjct: 252 --------------QESWL-TGASYVGVTAGASAPDILVQQVIQRLKEL 285
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>ISPH_XANOR (Q5H2D9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 40/109 (36%), Positives = 58/109 (53%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L ++  DL+LV+G  NSSN++ L E+    G+ SY ID+   I P 
Sbjct: 198 ICYATQNRQDAVRDLARQ-CDLVLVVGSPNSSNSNRLSELARRDGVESYLIDNASEIDPA 256

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                            W+  G   IG+T+GAS P  +V+  L ++ E+
Sbjct: 257 -----------------WI-VGKQHIGLTAGASAPQVLVDGVLARLREL 287
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>ISPH_PSEAE (Q9HVM7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 39/110 (35%), Positives = 60/110 (54%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           N IC ATQ RQDA+  L  ++ D++LV+G  NSSN++ L+E+ E  G P+Y ID  + + 
Sbjct: 195 NDICYATQNRQDAVKELA-DQCDMVLVVGSPNSSNSNRLRELAERMGTPAYLIDGAEDMQ 253

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            G                 W  +G   IG+T+GAS P+ +V   + ++ E
Sbjct: 254 RG-----------------WF-DGVRRIGITAGASAPEVLVRGVIAQLRE 285
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>ISPH_MANSM (Q65RQ4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 40/111 (36%), Positives = 60/111 (54%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           N IC AT  RQ A+  L  E+ DL++V+G  NSSN++ L E+    G+P+  ID    I 
Sbjct: 194 NDICYATTNRQQAVRELA-EQSDLVIVVGSKNSSNSNRLAELASRMGVPAKLIDDSNDIE 252

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
           P                 +WL +G  TIGVT+GAS P+ +V+  + ++ E+
Sbjct: 253 P-----------------DWL-KGINTIGVTAGASAPEVLVQSVIARLKEL 285
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>ISPH_BACHD (Q9KD37) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 48/153 (31%), Positives = 78/153 (50%), Gaps = 1/153 (0%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           D+  +K+ I NQTTM + +  EI     K  M K+    A  H    N IC ATQ RQ+A
Sbjct: 158 DISADKIIITNQTTMSQWDVSEI----MKKAMEKY--PQAEVH----NEICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIGE-LSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +    +E  DL++V+G   S+N++ L ++ E ++G  +Y I                  G
Sbjct: 208 VAEQARE-CDLVIVVGDPKSNNSNRLAQVSEQIAGTKAYRI------------------G 248

Query: 435 ELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
           ++ E +    +G  T+GVT+GASTP  + ++ +
Sbjct: 249 DVTELQQEWFDGVETVGVTAGASTPTPITKEVI 281
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>ISPH_PHOPR (Q6LUK8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 313

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 44/153 (28%), Positives = 71/153 (46%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D   +   +QTT+   ET ++   + K      G           + IC ATQ RQDA+ 
Sbjct: 157 DPSNLHYVSQTTLSVDETADVIDQLRKVFPEIQGPRK--------DDICYATQNRQDAVR 208

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  E VD+++V+G  NSSN++ L+E+ E  G P +  D  + + P              
Sbjct: 209 EMA-ESVDVMIVVGSKNSSNSNRLRELSEKLGTPGFLTDCPEDVQP-------------- 253

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
               W  EG   +GVT+GAS P+ +V   + ++
Sbjct: 254 ---VWF-EGKTKVGVTAGASAPEDLVNQIISRI 282
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>ISPH_IDILO (Q5QZR7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 40/108 (37%), Positives = 59/108 (54%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L  +  D++LV+G  NSSN++ L+E+ E  G P+Y ID    I   
Sbjct: 196 ICYATQNRQDAVRELASD-ADVMLVVGARNSSNSNRLRELSEKMGTPAYLIDDASCID-- 252

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
                          + WL EG   + VT+GAS P+ +V++ + K+ E
Sbjct: 253 ---------------KAWL-EGHEKVAVTAGASAPEVLVKEVIAKLQE 284
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>ISPH_WOLSU (Q7M8Y6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 276

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 49/151 (32%), Positives = 72/151 (47%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EKV + +QTT          K+ +   +  F V+   E  + FNTIC+AT + Q+A  HL
Sbjct: 150 EKVALVSQTTK---------KIEDFLGVASFLVQRCAEVRI-FNTICNATFDNQEAARHL 199

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            +E VD++++ GG NSSNT  L  I       SY I+ E  + P                
Sbjct: 200 SQE-VDIMIIAGGKNSSNTKQLLSICLEHCQDSYLIEDESELDP---------------- 242

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
             W      T GVT+GASTP+ ++E  +  +
Sbjct: 243 -QWFTNKK-TCGVTAGASTPEWIIERVVRTI 271
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>ISPH_TREDE (Q73NQ6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 289

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 47/146 (32%), Positives = 70/146 (47%)
 Frame = +3

Query: 111 QTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVDL 290
           QTT+ + E E I   ++K +               FNTIC AT +RQ A+  L  E VD 
Sbjct: 173 QTTIKESEYEAIASALKKRI----------SDLKVFNTICPATSDRQAALKKLAYE-VDA 221

Query: 291 ILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEG 470
           +LVIGG NS+NT  L +    +  P++ I+    I P    +Y +               
Sbjct: 222 LLVIGGKNSANTKRLFQTAVDTKKPAWLIEDASEI-PKEIFSYSV--------------- 265

Query: 471 PITIGVTSGASTPDKVVEDTLHKVFE 548
              IG+T+GASTPD ++++   K+ E
Sbjct: 266 ---IGLTAGASTPDFIIDEVEKKLLE 288
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>ISPH_VIBF1 (Q5E7N1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 38/106 (35%), Positives = 58/106 (54%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  +  + VD+++V+G  NSSN++ L+E+ E  G  SY ID  + +   
Sbjct: 196 ICYATQNRQDAVRDMASQ-VDVMIVVGSKNSSNSNRLRELSEKLGTTSYLIDCPEDL--- 251

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
                          E WL E    +GVT+GAS P+++V   + +V
Sbjct: 252 --------------KEEWLTE-QTKVGVTAGASAPEELVNQIIEQV 282
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>ISPH_PASMU (P57960) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 51/173 (29%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
 Frame = +3

Query: 84  DLEKVGIAN--------QTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDAT 239
           D+ K+G+          QTT+   +T E+   +E    +   ++   +     N IC AT
Sbjct: 149 DIAKLGLRQEDDLTFMTQTTLSIDDTSEV---IEALKQKYPAIQGPRK-----NDICYAT 200

Query: 240 QERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAY 419
             RQ A+  L ++  DL++V+G  NSSN++ L E+    G+ S  ID    I P      
Sbjct: 201 TNRQQAVRELAQQS-DLVIVVGSKNSSNSNRLAELASRMGVVSKLIDDANDIDP------ 253

Query: 420 KLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE--IKRQEVLQ 572
                       WL E   TIG+T+GAS P+ +V+  + ++ E  + R E LQ
Sbjct: 254 -----------TWL-ENVTTIGITAGASAPEVLVQSVVKRLQELGVTRVEELQ 294
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>ISPH_YERPS (Q66ES1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 317

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/118 (33%), Positives = 65/118 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ+A+ +L  +  D++LV+G  NSSN++ L E+ +  G P+Y IDS   I   
Sbjct: 197 ICYATTNRQEAVRNLAND-ADIVLVVGSKNSSNSNRLAELVQRMGKPAYLIDSAADI--- 252

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA 578
                          E WL +G   IGVT+GAS PD +V+  + ++ ++   E ++++
Sbjct: 253 --------------QEFWL-QGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELS 295
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>ISPH_YERPE (P58680) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 317

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/118 (33%), Positives = 65/118 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ+A+ +L  +  D++LV+G  NSSN++ L E+ +  G P+Y IDS   I   
Sbjct: 197 ICYATTNRQEAVRNLAND-ADIVLVVGSKNSSNSNRLAELVQRMGKPAYLIDSAADI--- 252

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA 578
                          E WL +G   IGVT+GAS PD +V+  + ++ ++   E ++++
Sbjct: 253 --------------QEFWL-QGAKCIGVTAGASAPDILVQQVIARLKDLGAGESIELS 295
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>ISPH_HELPY (P65185) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 274

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 48/156 (30%), Positives = 78/156 (50%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           +L++  +  +  ++   T++  KL++   +  + VE   E  + FNTIC+AT   Q A  
Sbjct: 142 ELQEKKLQRKVALVSQTTKQTPKLLQ---IASYLVERCTEVRI-FNTICNATSYNQKAAL 197

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            L KE VD+++V+GG  SSNT  L  I +     SY ++ E             N  EL 
Sbjct: 198 DLSKE-VDIMIVVGGKTSSNTKQLLSIAKQHCKDSYLVEDE-------------NELELA 243

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
               W  +  +  G+T+GASTPD ++E+   K+  I
Sbjct: 244 ----WFKDKKL-CGITAGASTPDWIIENVKQKISTI 274
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>ISPH_HELPJ (P65186) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 274

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 48/156 (30%), Positives = 78/156 (50%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           +L++  +  +  ++   T++  KL++   +  + VE   E  + FNTIC+AT   Q A  
Sbjct: 142 ELQEKKLQRKVALVSQTTKQTPKLLQ---IASYLVERCTEVRI-FNTICNATSYNQKAAL 197

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            L KE VD+++V+GG  SSNT  L  I +     SY ++ E             N  EL 
Sbjct: 198 DLSKE-VDIMIVVGGKTSSNTKQLLSIAKQHCKDSYLVEDE-------------NELELA 243

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
               W  +  +  G+T+GASTPD ++E+   K+  I
Sbjct: 244 ----WFKDKKL-CGITAGASTPDWIIENVKQKISTI 274
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>ISPH_STRAW (Q82IE8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 338

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 51/150 (34%), Positives = 76/150 (50%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D  KV   +QTT+   ET E    +++   +     +        + IC ATQ RQ A+ 
Sbjct: 163 DPSKVVWLSQTTLSVDETMETVDALKEKFPQLISPPS--------DDICYATQNRQLAVK 214

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  E+ DL++V+G  NSSN+  L E+ +L+G                R AY ++  + I
Sbjct: 215 QM-GEEADLVIVVGSRNSSNSVRLVEVAKLAGA---------------RDAYLVDFADEI 258

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTL 533
           + E WL EG  T+GVTSGAS P+ +VE  L
Sbjct: 259 D-EAWL-EGVSTVGVTSGASVPEILVEQVL 286
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>ISPH_HELHP (Q7VJV5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 273

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 50/154 (32%), Positives = 73/154 (47%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +KV + +QTT    + E  GK+          V   NE  + FNTIC AT E Q A+  L
Sbjct: 149 KKVALVSQTTK---QPEHFGKIAALL------VSLVNECRI-FNTICSATFENQFAVDEL 198

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            +E  D+++++GG NSSNT  L +I +     SY I+ E                   E 
Sbjct: 199 SRE-ADIMVIVGGKNSSNTKQLFKIAKEYCTDSYLIEDEN------------------EI 239

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
           +N    G    G+T+GASTPD ++     K+ +I
Sbjct: 240 DNTWFVGKELCGITAGASTPDWIISRVQEKIEQI 273
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>ISPH_PSESM (Q889E1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 315

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 44/151 (29%), Positives = 69/151 (45%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           E +    QTT+   +T  +   + K      G           + IC ATQ RQDA+  L
Sbjct: 160 ESLAFVTQTTLSMDDTSRVIDALRKRFPAIGGPRK--------DDICYATQNRQDAVKQL 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E  D++LV+G  NSSN++ L+E+ E    P+Y ID  + +  G               
Sbjct: 212 ADE-CDVVLVVGSPNSSNSNRLRELAERMATPAYLIDGAEDMQKG--------------- 255

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
             W  +G   IG+T+GAS P+ +V   + ++
Sbjct: 256 --WF-DGVERIGITAGASAPEVLVRGVIQQL 283
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>ISPH_NITEU (Q82WM1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 323

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 44/145 (30%), Positives = 74/145 (51%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  LVK   DL++V+G  NSSN++ L E+     + +Y +D  +++   
Sbjct: 197 ICYATQNRQDAVKKLVK-LCDLVVVVGSPNSSNSNRLCEVARNENVEAYMVDQAEQL--- 252

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA*I 584
                          E+WL      IG+T+GAS P+ +V+  L ++ +I  ++       
Sbjct: 253 --------------QESWL-TNKRCIGITAGASAPEILVQQVLERLEQIAAKQ------- 290

Query: 585 FSKIGQGIIIADGLAKVSRTIARPI 659
                QG+II + L+ V  ++  P+
Sbjct: 291 ---SNQGVIIEE-LSGVLESVTFPL 311
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>ISPH_PHOLL (Q7N8W9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 317

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 45/164 (27%), Positives = 75/164 (45%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +    QTT+   +T E+   +        G           + IC AT  RQ+A+ 
Sbjct: 158 DEDNLCFMTQTTLSVDDTSEVIDALNARFPNIVGPRK--------DDICYATTNRQEAVR 209

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            L  +  D++LV+G  NSSN++ L E+ +  G P+Y IDS + I                
Sbjct: 210 DLASD-ADVVLVVGSKNSSNSNRLAELAQRVGKPAYLIDSAEDI---------------- 252

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
             E W+  G   +GVT+GAS PD +V+  + ++  +    V ++
Sbjct: 253 -KEEWI-TGISLVGVTAGASAPDILVQQVIERLKSLGADSVQEL 294
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>ISPH_PSEPK (Q88Q89) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 315

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 37/106 (34%), Positives = 56/106 (52%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC ATQ RQDA+  L  E  D++LV+G  NSSN++ L+E+ E  G P+Y ID  + +  G
Sbjct: 197 ICYATQNRQDAVKQLAGES-DVVLVVGSPNSSNSNRLRELAERMGTPAYLIDGAEDLQRG 255

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
                            W  +    IG+T+GAS P+ +V   + ++
Sbjct: 256 -----------------WFDQA-ARIGITAGASAPEVLVRGVIEQL 283
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>ISPH_NEIMB (P65192) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 322

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 47/148 (31%), Positives = 74/148 (50%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+   +QTT+   ET++I   +     R   + N ++       IC AT  RQ A+  L
Sbjct: 160 DKLAYVSQTTLSVDETKDI---IAALNARFPNIRNPHKE-----DICYATTNRQTAVKEL 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ D+++V+G  NSSN++ L+E+    GI +Y +D               N G L  A
Sbjct: 212 A-EQCDIVIVVGSPNSSNSNRLREVAASRGIDAYMVD---------------NAGYLQRA 255

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTL 533
             W  EG   +GVT+GAS P+ +V + L
Sbjct: 256 --WF-EGKNKVGVTAGASAPEVLVREVL 280
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>ISPH_NEIMA (P65191) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 322

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 47/148 (31%), Positives = 74/148 (50%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+   +QTT+   ET++I   +     R   + N ++       IC AT  RQ A+  L
Sbjct: 160 DKLAYVSQTTLSVDETKDI---IAALNARFPNIRNPHKE-----DICYATTNRQTAVKEL 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ D+++V+G  NSSN++ L+E+    GI +Y +D               N G L  A
Sbjct: 212 A-EQCDIVIVVGSPNSSNSNRLREVAASRGIDAYMVD---------------NAGYLQRA 255

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTL 533
             W  EG   +GVT+GAS P+ +V + L
Sbjct: 256 --WF-EGKNKVGVTAGASAPEVLVREVL 280
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>ISPH_PARUW (Q6MC97) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 313

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 47/159 (29%), Positives = 78/159 (49%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+    QTT+   + +EI + +         V+  +   +  ++IC AT  RQ A+  +
Sbjct: 156 DKLFYITQTTLSLDDVKEITQALI--------VKYPHVETLPSSSICYATTNRQMALREI 207

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             +  DL+LV+G   SSN++ L+E     GI SY I+ E+ I P                
Sbjct: 208 T-DLTDLVLVVGDPQSSNSNRLREAASTRGIESYLINDEKEIHP---------------- 250

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEV 566
             WL  G   IG+T+GASTP+++V+  +  + E+   EV
Sbjct: 251 -EWL-LGKQVIGLTAGASTPEEIVQKCIQCLIELGVNEV 287
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>ISPH_ACIAD (Q9RBJ0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 40/151 (26%), Positives = 76/151 (50%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+    QTT+     ++  K+++    +   ++   +     + IC ATQ RQDA+  L
Sbjct: 160 EKLAFVTQTTL---SIDDTAKVIDALRTKFPQIQGPRK-----DDICYATQNRQDAVRDL 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
              + D++LV+G  NSSN++ L+E+ E  G  +Y +D+  ++                  
Sbjct: 212 AS-RCDVVLVVGSPNSSNSNRLRELAERMGKAAYLVDNADQL-----------------E 253

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
           + W  +G   IGVT+GAS P+ +++  + ++
Sbjct: 254 QQWF-DGVAKIGVTAGASAPEILIKQVIQRL 283
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>ISPH_CLOTE (Q895G2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 635

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 46/129 (35%), Positives = 68/129 (52%)
 Frame = +3

Query: 186 VENANEHFVAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIP 365
           V N     VAFNTIC+AT+ RQ +   L KE VD ++VIG  +SSNT+ L EI + +   
Sbjct: 177 VVNECREVVAFNTICNATEVRQLSAEDLSKE-VDFMIVIGSKSSSNTTKLYEICKNNCSN 235

Query: 366 SYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVF 545
           +  I+               N GEL    +++      IGVT+GASTPD ++++ + K+ 
Sbjct: 236 TIHIE---------------NAGEL---PDYISNKYSKIGVTAGASTPDWIIKEAIFKMS 277

Query: 546 EIKRQEVLQ 572
                E L+
Sbjct: 278 NKNLNEQLE 286
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>ISPH_AQUAE (O67625) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 289

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 9/160 (5%)
 Frame = +3

Query: 99  GIANQTTMLKGET---EEIGKLVEKTMMRKFGVENANE------HFVAFNTICDATQERQ 251
           GI  +T    GE    E +G + + T   +F  E   E           NTIC+AT  RQ
Sbjct: 141 GIVVETLEDIGEALKHERVGIVAQTTQNEEFFKEVVGEIALWVKEVKVINTICNATSLRQ 200

Query: 252 DAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNH 431
           +++  L  E VD++++IGG NS NT  L  I +     +Y I++ + + P          
Sbjct: 201 ESVKKLAPE-VDVMIIIGGKNSGNTRRLYYISKELNPNTYHIETAEELQP---------- 249

Query: 432 GELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                   W   G   +G+++GASTPD ++E    ++ EI
Sbjct: 250 -------EWF-RGVKRVGISAGASTPDWIIEQVKSRIQEI 281
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>ISPH_NEIG1 (Q5FAF2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 322

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 43/148 (29%), Positives = 72/148 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+   +QTT+   ET++I   +     R   + N ++       IC AT  RQ A+  L
Sbjct: 160 DKLAYVSQTTLSVDETKDI---IAALNARFPNIRNPHKE-----DICYATTNRQTAVKEL 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ D+++V+G  NSSN++ L+E+    GI +Y +D+   +                  
Sbjct: 212 A-EQCDIVIVVGSPNSSNSNRLREVAASRGIDAYMVDNASYL-----------------Q 253

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTL 533
             W  EG   +GVT+GAS P+ +V + L
Sbjct: 254 RTWF-EGKSKVGVTAGASAPEVLVREVL 280
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>ISPH_BUCAP (Q8K9Z4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 313

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 48/148 (32%), Positives = 73/148 (49%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+    QTT+    T+ I   ++K  +   G +  +        IC AT  RQ+A+  L
Sbjct: 159 KKLNFFTQTTLSIKNTQSIILALKKKFLNISGPKKED--------ICYATTNRQNAIIKL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            K   D+ILVIG  NSSN+S L E+G+ +G+ +  I+S   I                  
Sbjct: 211 SKI-TDIILVIGSKNSSNSSRLSELGKETGVFTKQIESFSDI-----------------K 252

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTL 533
           E WL +    IG+T+GAS PD +VE+ +
Sbjct: 253 EEWL-KNKKNIGITAGASAPDILVEEVI 279
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>ISPH_STRCO (Q9FBM1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 338

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 49/150 (32%), Positives = 74/150 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D  KV   +QTT+   ET E    ++    +     +        + IC ATQ RQ A+ 
Sbjct: 163 DPSKVVWLSQTTLSVDETMETVDALKDKFPQLISPPS--------DDICYATQNRQLAVK 214

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  E  +L++V+G  NSSN+  L E+ + +G               +R AY ++  + I
Sbjct: 215 QMGAE-AELVIVVGSRNSSNSKRLVEVAKQAG---------------SRAAYLVDFADEI 258

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTL 533
           + E WL +G  T+GVTSGAS PD +VE  L
Sbjct: 259 D-ETWL-DGVTTVGVTSGASVPDVLVEQVL 286
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>ISPH_BACSU (P54473) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 47/154 (30%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           D+  EK+ + NQTTM + +  +I +LV++             H      IC ATQ RQ+A
Sbjct: 158 DIQSEKLIVTNQTTMSQWDVHDIMELVKEKY----------PHVEYHQEICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIGE-LSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +    K K DL +V+G   S+N++ L ++ E ++G  +Y I                  G
Sbjct: 208 VSEQAK-KADLTIVVGDPKSNNSNRLAQVSEEIAGTKAYRI------------------G 248

Query: 435 ELIEAE-NWLPEGPITIGVTSGASTPDKVVEDTL 533
           +L E +  WL +G  T+ VT+GASTP  + ++ +
Sbjct: 249 DLSELKLEWL-KGVNTVAVTAGASTPTPITKEVI 281
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>ISPH2_MYCTU (P0A5I2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (EC|
           1.17.1.2)
          Length = 329

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 40/99 (40%), Positives = 51/99 (51%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ A+  +V E  D++LVIG  NSSN+  L E+ + SG P+Y ID    I P 
Sbjct: 214 ICYATTNRQRALQSMVGE-CDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEP- 271

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVV 521
                            WL     TIGVT+GAS P ++V
Sbjct: 272 ----------------EWL-SSVSTIGVTAGASAPPRLV 293
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>ISPH2_MYCBO (P0A5I3) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (EC|
           1.17.1.2)
          Length = 329

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 40/99 (40%), Positives = 51/99 (51%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ A+  +V E  D++LVIG  NSSN+  L E+ + SG P+Y ID    I P 
Sbjct: 214 ICYATTNRQRALQSMVGE-CDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEP- 271

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVV 521
                            WL     TIGVT+GAS P ++V
Sbjct: 272 ----------------EWL-SSVSTIGVTAGASAPPRLV 293
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>ISPH_MYCPA (Q73WH6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 332

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 52/155 (33%), Positives = 79/155 (50%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D +KV   +QTT+   ET EI   VE+   R   +++        + IC ATQ RQ A+ 
Sbjct: 176 DEDKVVWLSQTTLSVDETMEI---VERLRQRFPKLQDPPS-----DDICYATQNRQVAVK 227

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  E  DL++V+G  NSSN+  L E+                +G G   A+ ++  + I
Sbjct: 228 AMAPE-CDLVIVVGSRNSSNSVRLVEVA---------------LGGGAGAAHLVDWADDI 271

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
           +   WL EG  T+GVTSGAS P+ +V+  L ++ E
Sbjct: 272 DPA-WL-EGVTTVGVTSGASVPEVLVQGVLERLAE 304
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>ISPH_BACLD (Q65H97) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 49/154 (31%), Positives = 79/154 (51%), Gaps = 2/154 (1%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           D++ EK+ + NQTTM + +  +I   +EK   +   VE   E       IC ATQ RQ+A
Sbjct: 158 DIEAEKLIVTNQTTMSQWDVHDI---MEKVKEKYPDVEFHQE-------ICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIGE-LSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +    K K DL +V+G   S+N++ L ++ E ++G  +Y I                  G
Sbjct: 208 VSEQAK-KADLTIVVGDPKSNNSNRLAQVSEEIAGTKAYRI------------------G 248

Query: 435 ELIEAE-NWLPEGPITIGVTSGASTPDKVVEDTL 533
           +L E +  WL +G  T+ VT+GASTP  + ++ +
Sbjct: 249 DLSELKLEWL-DGVETVAVTAGASTPTPITKEVI 281
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>ISPH_CAMJR (Q5HUR4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 277

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 44/154 (28%), Positives = 76/154 (49%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+ + +QTT    + E   ++V   +++   V         FNTICDAT + QDA+  L 
Sbjct: 151 KIAVVSQTTK---KPEHFMEIVNFLILKTKEVR-------VFNTICDATFKNQDAIKEL- 199

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
             K D+++V+GG NS+NT  L  I + +   SY I++E+ +                  +
Sbjct: 200 SLKSDVMVVVGGKNSANTKQLFLIAKTNCEDSYLIETEEEL-----------------KK 242

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIK 554
            W  +     G+++GASTPD +++  + K+   K
Sbjct: 243 EWFLDKK-HCGISAGASTPDWIIQKVIAKIENFK 275
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>ISPH_CORGL (Q8NRM2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 325

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 49/164 (29%), Positives = 79/164 (48%), Gaps = 1/164 (0%)
 Frame = +3

Query: 108 NQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVD 287
           +QTT+   ET EI        +R+  V+         + IC ATQ RQ A+   + E+ +
Sbjct: 177 SQTTLSVDETMEI--------VRELKVKFPQLQDPPSDDICYATQNRQVAV-KAIAERCE 227

Query: 288 LILVIGGWNSSNTSHLQEIGELSGIPS-YWIDSEQRIGPGNRIAYKLNHGELIEAENWLP 464
           L++V+G  NSSN+  L E+ + +G  + Y +D  + I P                  W  
Sbjct: 228 LMIVVGSRNSSNSVRLVEVAKQNGADNAYLVDYAREIDPA-----------------WF- 269

Query: 465 EGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA*IFSKI 596
           EG  TIG++SGAS P+ +V+  + ++ E    +V +V     KI
Sbjct: 270 EGVETIGISSGASVPEILVQGVIERLAEFGYDDVEEVTSAAEKI 313
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>ISPH_SYMTH (Q67QZ8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 295

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 44/144 (30%), Positives = 74/144 (51%), Gaps = 1/144 (0%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+ + NQTT+ + +T+    L+E+   R    E        +N IC ATQ+RQ+A+  +
Sbjct: 163 QKLAVTNQTTLSQWDTQA---LMEQVKARWPQTE-------IYNEICLATQQRQEAVARM 212

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIE 446
             E  DL++V+G   S+N++ L ++  EL+   ++ +DS + I P               
Sbjct: 213 APE-ADLVIVVGDRRSNNSNRLVQVAQELAAREAHLVDSVEEIDPA-------------- 257

Query: 447 AENWLPEGPITIGVTSGASTPDKV 518
              WL +G   + VTSGASTP  +
Sbjct: 258 ---WL-KGKRKVAVTSGASTPTHI 277
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>ISPH_PROAC (Q6AA89) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 323

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 42/104 (40%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIP-SYWIDSEQRIGP 401
           IC ATQ RQ A+  +  +  DL++V+G  NSSNT  L E+   SG   SY +D       
Sbjct: 202 ICYATQNRQHAVKQMAPQ-CDLVIVVGSKNSSNTGRLVEVALESGAKASYRVD------- 253

Query: 402 GNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                   N GE+   E WL +G  TIGVTSGAS P+ +V+  +
Sbjct: 254 --------NAGEI--EETWL-DGVSTIGVTSGASVPEALVQGVI 286
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>ISPH_LEIXX (Q6ADV0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 337

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 48/150 (32%), Positives = 74/150 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D ++V   +QTT+   ET E         +R+      N      + IC ATQ RQ A+ 
Sbjct: 167 DPDRVVWLSQTTLSVDETMET--------VRRLRERFPNLQNPPSDDICYATQNRQVAIK 218

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
             V +  DL++V+G  NSSN+  L E+                +  G + AY++++   I
Sbjct: 219 K-VAQSADLVIVVGSANSSNSVRLVEVA---------------LEYGAKAAYRVDYASEI 262

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTL 533
             E WL +G  T+GVTSGAS P+ +V++ L
Sbjct: 263 RQE-WL-DGVATVGVTSGASVPEVLVQEVL 290
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>ISPH_FUSNN (Q8RI52) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 827

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
 Frame = +3

Query: 81  VDLEKVGI-ANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           +DL+K  + + QTT+ K + EEI         +K+  EN  ++ V F+ IC AT  RQ A
Sbjct: 156 IDLDKTYLLSTQTTLNKKKFEEI---------KKYFKENY-KNVVIFDKICGATAVRQKA 205

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGE 437
           +  L   KV++++++G   SSNT  L EI +     SY +++E+++              
Sbjct: 206 VEDLAV-KVEVMIIVGDTKSSNTKKLYEISKKLNDNSYLVENEEQL-------------- 250

Query: 438 LIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
               +  +  G   +G+T+GASTP++ + +   KV
Sbjct: 251 ----DLSIFRGKEVVGITAGASTPEETIMNIEKKV 281
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>ISPH_WIGBR (Q8D2R2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 315

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 41/119 (34%), Positives = 63/119 (52%), Gaps = 2/119 (1%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT+ RQ ++  ++K  VD+I +IG  NSSN++ L EI   SG  SY ID+ + I   
Sbjct: 196 ICYATENRQKSIKKIIK-LVDIIFIIGSKNSSNSNRLFEIANKSGKKSYLIDTYKEI--- 251

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLH--KVFEIKRQEVLQV 575
                          ++WL  G   IG+T+GAS P+ +V+  ++  K+F      + QV
Sbjct: 252 --------------KKSWL-NGVNNIGITAGASAPEILVQQVVNYLKIFYKNSVNIYQV 295
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>ISPH_SHIFL (Q7UDT8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 77/160 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L
Sbjct: 159 EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRAL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ +++LV+G  NSSN++ L E+ +  G  ++ ID  + I                  
Sbjct: 211 A-EQAEVVLVVGSKNSSNSNRLAELAQRMGKHAFLIDDAKDI-----------------Q 252

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVL 569
           E W+ E    +GVT+GAS PD +V++ + ++ ++   E +
Sbjct: 253 EEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAI 291
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>ISPH_SALTY (P58679) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/152 (28%), Positives = 72/152 (47%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L 
Sbjct: 160 KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRALA 211

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
            E+ D++LV+G  NSSN++ L E+ +  G  ++ ID    I                  E
Sbjct: 212 -EQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADI-----------------QE 253

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            W+ E    +GVT+GAS PD +V++ + ++ E
Sbjct: 254 AWVKEA-ACVGVTAGASAPDILVQNVIARLRE 284
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>ISPH_SALCH (Q57TL2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/152 (28%), Positives = 72/152 (47%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L 
Sbjct: 160 KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRALA 211

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
            E+ D++LV+G  NSSN++ L E+ +  G  ++ ID    I                  E
Sbjct: 212 -EQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADI-----------------QE 253

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            W+ E    +GVT+GAS PD +V++ + ++ E
Sbjct: 254 AWVKEA-ACVGVTAGASAPDILVQNVIARLRE 284
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>ISPH_ECOLI (P62623) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 77/160 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L
Sbjct: 159 EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRAL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ +++LV+G  NSSN++ L E+ +  G  ++ ID  + I                  
Sbjct: 211 A-EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDI-----------------Q 252

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVL 569
           E W+ E    +GVT+GAS PD +V++ + ++ ++   E +
Sbjct: 253 EEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAI 291
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>ISPH_ECOL6 (P62624) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 77/160 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L
Sbjct: 159 EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRAL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ +++LV+G  NSSN++ L E+ +  G  ++ ID  + I                  
Sbjct: 211 A-EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDI-----------------Q 252

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVL 569
           E W+ E    +GVT+GAS PD +V++ + ++ ++   E +
Sbjct: 253 EEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAI 291
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>ISPH_ECO57 (P62625) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 77/160 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L
Sbjct: 159 EKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRAL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E+ +++LV+G  NSSN++ L E+ +  G  ++ ID  + I                  
Sbjct: 211 A-EQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDI-----------------Q 252

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVL 569
           E W+ E    +GVT+GAS PD +V++ + ++ ++   E +
Sbjct: 253 EEWVKEVK-CVGVTAGASAPDILVQNVVARLQQLGGGEAI 291
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>ISPH_CAMJE (P94644) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 277

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 43/150 (28%), Positives = 75/150 (50%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+ + +QTT    + E   ++V   +++   V         FNTICDAT + QDA+  L 
Sbjct: 151 KIAVVSQTTK---KPEHFMEIVNFLILKTKEVR-------VFNTICDATFKNQDAIKEL- 199

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
             K D+++V+GG NS+NT  L  I + +   SY I++E+ +                  +
Sbjct: 200 SLKSDVMVVVGGKNSANTKQLFLIAKTNCEDSYLIETEEEL-----------------KK 242

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
            W  +     G+++GASTPD +++  + K+
Sbjct: 243 EWFLDKK-HCGISAGASTPDWIIQKVIAKI 271
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>ISPH_SHEON (Q8EBI7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 318

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 45/164 (27%), Positives = 78/164 (47%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D   +    QTT+   +T +I   +   + R   +E   +     + IC ATQ RQDA+ 
Sbjct: 166 DPNNLCFVTQTTLSVDDTLDI---ISALLKRFPSIEGPRK-----DDICYATQNRQDAVR 217

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
           +L  + VDL++V+G  NSSN++ L+E+   +G  SY +D+   I                
Sbjct: 218 NLSAD-VDLLIVVGSKNSSNSNRLRELALKTGTQSYLVDTADDID--------------- 261

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
              +W  E    + VT+GAS P+ +V+  +  + ++    V +V
Sbjct: 262 --SSWF-ENITKVAVTAGASAPEVLVQQVVQAIAKLAPSVVTEV 302
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>ISPH_FRATT (Q5NGK4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 318

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 42/161 (26%), Positives = 80/161 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +  A QTT+   ET+ I + ++       G +  +        IC ATQ RQ A+ 
Sbjct: 157 DPDNLYYATQTTLSVDETQGIIQALKDKYPNIKGPKKED--------ICYATQNRQTAIK 208

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            ++K  +D+++V+G  NSSN++ L+E+  L GI +Y +D+ + +                
Sbjct: 209 AMLKH-IDVLVVVGSQNSSNSNRLKELATLEGIDAYLVDNPKDVD--------------- 252

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEV 566
             + W     +  GV++GAS P+ +V+  + ++ ++   EV
Sbjct: 253 --KLWFDNKKV-CGVSAGASAPEYLVQQIISQISKVCSTEV 290
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>ISPH1_MYCTU (P0A5I0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC|
           1.17.1.2)
          Length = 335

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 52/156 (33%), Positives = 79/156 (50%), Gaps = 1/156 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEI-GKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAM 260
           D +KV   +QTT+   ET EI G+L      R+F            + IC ATQ RQ A+
Sbjct: 179 DEDKVVWLSQTTLSVDETMEIVGRL-----RRRF----PKLQDPPSDDICYATQNRQVAV 229

Query: 261 YHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGEL 440
             +  E  +L++V+G  NSSN+  L E+                +G G R A+ ++  + 
Sbjct: 230 KAMAPE-CELVIVVGSRNSSNSVRLVEVA---------------LGAGARAAHLVDWADD 273

Query: 441 IEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
           I++  WL +G  T+GVTSGAS P+ +V   L ++ E
Sbjct: 274 IDSA-WL-DGVTTVGVTSGASVPEVLVRGVLERLAE 307
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>ISPH1_MYCBO (P0A5I1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC|
           1.17.1.2)
          Length = 335

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 52/156 (33%), Positives = 79/156 (50%), Gaps = 1/156 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEI-GKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAM 260
           D +KV   +QTT+   ET EI G+L      R+F            + IC ATQ RQ A+
Sbjct: 179 DEDKVVWLSQTTLSVDETMEIVGRL-----RRRF----PKLQDPPSDDICYATQNRQVAV 229

Query: 261 YHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGEL 440
             +  E  +L++V+G  NSSN+  L E+                +G G R A+ ++  + 
Sbjct: 230 KAMAPE-CELVIVVGSRNSSNSVRLVEVA---------------LGAGARAAHLVDWADD 273

Query: 441 IEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
           I++  WL +G  T+GVTSGAS P+ +V   L ++ E
Sbjct: 274 IDSA-WL-DGVTTVGVTSGASVPEVLVRGVLERLAE 307
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>ISPH_SALTI (P58678) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 42/152 (27%), Positives = 72/152 (47%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L 
Sbjct: 160 KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRALA 211

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
            E+ D++LV+G  NSSN++ L E+ +  G  ++ ID    I                  E
Sbjct: 212 -EQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADI-----------------QE 253

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            W+ +    +GVT+GAS PD +V++ + ++ E
Sbjct: 254 AWVKDA-ACVGVTAGASAPDILVQNVIARLRE 284
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>ISPH_SALPA (Q5PKI4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 42/152 (27%), Positives = 72/152 (47%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+    QTT+   +T ++   + K   +  G           + IC AT  RQ+A+  L 
Sbjct: 160 KLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRK--------DDICYATTNRQEAVRALA 211

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
            E+ D++LV+G  NSSN++ L E+ +  G  ++ ID    I                  E
Sbjct: 212 -EQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADI-----------------QE 253

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
            W+ +    +GVT+GAS PD +V++ + ++ E
Sbjct: 254 AWVKDA-ACVGVTAGASAPDILVQNVIARLRE 284
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>ISPH_WOLTR (Q5GTN6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 309

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 44/149 (29%), Positives = 73/149 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           + +    QTT+   +T EI   +    +R   +   N        IC ATQ RQ+A+  L
Sbjct: 159 DNLSYVTQTTLSTDDTREI---ITALKLRFPNITGPN-----LKDICYATQNRQNAVKKL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             E VD++L+IG  NSSN++ L ++    G  +Y ID+   +                  
Sbjct: 211 T-EIVDIVLIIGSKNSSNSNRLLDLCTARGKRAYLIDNYSYMD----------------- 252

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLH 536
           ++WL +G   IG+T+GAS PD +V++ ++
Sbjct: 253 KSWL-QGIEKIGITAGASAPDILVDELIN 280
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>ISPH_CHLTR (O84867) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 307

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 38/111 (34%), Positives = 60/111 (54%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           ++IC ATQ RQ A+ +++ + VD + VIG   SSN++ L+E+ E  G+            
Sbjct: 192 SSICYATQNRQGALRNILPQ-VDFVYVIGDTQSSNSNRLREVAERRGVT----------- 239

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                A  +NH + +  E     G   IG+T+GASTP+ VV+  L K+ E+
Sbjct: 240 -----ARLVNHPDEVTEEILQYSG--NIGITAGASTPEDVVQACLMKLQEL 283
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>ISPH_BACSK (Q5WHC6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 46/153 (30%), Positives = 75/153 (49%), Gaps = 2/153 (1%)
 Frame = +3

Query: 81  VDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAM 260
           +D   + I NQTTM + +  +I K   +         NA  H    N IC ATQ RQ+A+
Sbjct: 159 LDDRDIIITNQTTMSQWDVADIMKRAMELY------PNAEVH----NEICLATQVRQEAV 208

Query: 261 YHLVKEKVDLILVIGGWNSSNTSHLQEIGE-LSGIPSYWIDSEQRIGPGNRIAYKLNHGE 437
                +  D+++V+G   S+N++ L ++ E ++G P+Y I                  G+
Sbjct: 209 AEQASQ-CDIVIVVGDPKSNNSNRLAQVSEQIAGTPAYRI------------------GD 249

Query: 438 LIEAE-NWLPEGPITIGVTSGASTPDKVVEDTL 533
           L E +  W+ E    +GVTSGASTP  + ++ +
Sbjct: 250 LSELKLEWIKEAK-KVGVTSGASTPTPITKEVI 281
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>ISPH_CORDI (Q6NI36) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 333

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 47/149 (31%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           EK+   +QTT+   ET         T+++K     A+      + IC ATQ RQ A+  +
Sbjct: 178 EKLIWLSQTTLSVDET--------MTIVKKLHERFAHLQDPPSDDICYATQNRQVAVKAI 229

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGI-PSYWIDSEQRIGPGNRIAYKLNHGELIE 446
             E  D+++V+G  NSSN+  L E+   +G   SY +D   +I                 
Sbjct: 230 AAES-DVVIVVGSQNSSNSKRLVEVALQAGAGASYLVDYAHQID---------------- 272

Query: 447 AENWLPEGPITIGVTSGASTPDKVVEDTL 533
            E+WL +G  T+GV+SGAS P+ +V   L
Sbjct: 273 -ESWL-DGATTVGVSSGASVPEILVRGVL 299
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>ISPH_HAEDU (Q7VPK4) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 37/105 (35%), Positives = 53/105 (50%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           N IC AT  RQ A+  L K+   L+LV+G  NSSN++ L E+    G+ +  ID  Q I 
Sbjct: 194 NDICYATTNRQQAVRELAKQ-AQLVLVVGSKNSSNSNRLAELASRMGVLAKLIDGPQDIL 252

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
           P                  WL +   TIG+T+GAS P+ +V+  +
Sbjct: 253 P-----------------EWL-DNVETIGITAGASAPEILVQSVV 279
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>ISPH_WOLPM (Q73FQ1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 309

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 43/150 (28%), Positives = 73/150 (48%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +    QTT+   +T +I   +    +R  G+   +        IC ATQ RQ+A+ 
Sbjct: 157 DPDNLSYVTQTTLSIDDTRDI---IAALKLRFPGITGPD-----LKDICYATQNRQNAVK 208

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            L  E VD++LV+G  NSSN++ L ++    G  +Y ID+   +                
Sbjct: 209 KLA-EIVDMVLVVGSKNSSNSNRLLDLCTARGKRAYLIDNYSCVN--------------- 252

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTL 533
             ++W  +G   IG+T+GAS PD +V++ +
Sbjct: 253 --KSWF-QGVEKIGITAGASAPDILVDELI 279
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>ISPH_COREF (Q8FQP0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 336

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 49/163 (30%), Positives = 80/163 (49%)
 Frame = +3

Query: 108 NQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVD 287
           +QTT+   ET EI + ++K   +     +        + IC ATQ RQ A+   + E+ D
Sbjct: 188 SQTTLSVDETMEIVRELKKVYPQLQDPPS--------DDICYATQNRQVAV-KAIAERCD 238

Query: 288 LILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPE 467
           L++V+G  NSSN+  L E+                +  G + AY +++   I+ E WL +
Sbjct: 239 LMIVVGSTNSSNSVRLVEVA---------------LQAGAKNAYLVDYAHQID-EAWL-D 281

Query: 468 GPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA*IFSKI 596
           G  TIG++SGAS P+ +V   L ++      +V +V     KI
Sbjct: 282 GVQTIGISSGASVPEILVTGVLERLAGYGFDDVEEVTTAAEKI 324
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>ISPH_ANAMM (Q5PAE7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 342

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 43/147 (29%), Positives = 68/147 (46%)
 Frame = +3

Query: 93  KVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLV 272
           K+    QTT+   +T EI   ++    R  G +           IC ATQ RQ A+   +
Sbjct: 194 KLAYVTQTTLSMDDTAEIISALKLRFPRIVGPD--------LRDICYATQNRQTAV-KAM 244

Query: 273 KEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAE 452
            + VD++L IG  NSSN++ L ++ +     +Y IDS + I                   
Sbjct: 245 SQMVDVVLAIGSKNSSNSNRLLDLAKAQNARAYLIDSYRNID-----------------L 287

Query: 453 NWLPEGPITIGVTSGASTPDKVVEDTL 533
            WL  G   IG+T+GAS P+ +V++ +
Sbjct: 288 EWL-IGARRIGITAGASAPEILVQEVI 313
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>ISPH_MYCLE (Q9X781) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 332

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 51/151 (33%), Positives = 72/151 (47%), Gaps = 1/151 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D  KV   +QTT+   ET  I   VE+   R   +++        + IC ATQ RQ A+ 
Sbjct: 176 DENKVVWLSQTTLSVDETMRI---VERLRQRFPKLQDPPS-----DDICYATQNRQVAVK 227

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGI-PSYWIDSEQRIGPGNRIAYKLNHGEL 440
            +  E  +L++V+G  NSSN+  L E+   SG   +Y +D  + I P             
Sbjct: 228 AMAPE-CELVIVVGSRNSSNSVRLVEVAMGSGAGAAYLVDWAKDIDPA------------ 274

Query: 441 IEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                WL  G  T+GVTSGAS PD +V+  L
Sbjct: 275 -----WLA-GVTTVGVTSGASVPDILVQGVL 299
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>ISPH_METCA (Q607E5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 313

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 46/153 (30%), Positives = 75/153 (49%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           + +    QTT+     ++ G +VE   MR   +    +     + IC ATQ RQDA+  L
Sbjct: 159 DNLAYVTQTTL---SIDDTGAVVEALKMRFPKILGPRK-----DDICYATQNRQDAVKKL 210

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
             +  D ILV+G  NSSN++ L+EI +  G  ++ ID+          A +L    +  A
Sbjct: 211 AAQ-CDTILVVGSPNSSNSNRLREIADKLGRKAFLIDN----------AAQLTRDMVAGA 259

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
           +         IGVT+GAS P+ +V+  + ++ E
Sbjct: 260 QR--------IGVTAGASAPEILVQQVIAQLKE 284
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>ISPH_CAUCR (Q9A345) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 319

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 3/166 (1%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D   V    QTT+   +T ++  L+ +   R  G+   ++       IC AT  RQDA+ 
Sbjct: 165 DAANVAFLTQTTLSVDDTADMVALLRE---RFPGIAAPHKE-----DICYATTNRQDAVK 216

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
           HL  E+ +LILV+G  NSSN+  L+E+G               +  G R A+ ++    I
Sbjct: 217 HLA-EQSELILVVGSKNSSNSVRLKEVG---------------LKAGARDAHLIDDASGI 260

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVE---DTLHKVFEIKRQEVLQ 572
           +   W  +G   +G+T+GAS P+ +V+   D +   F+   +E+++
Sbjct: 261 DW-TWF-DGISRVGLTAGASAPEDLVQGVIDAISARFDTTVEELVE 304
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>ISPH_NOCFA (Q5YQ94) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 336

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 50/161 (31%), Positives = 72/161 (44%), Gaps = 6/161 (3%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAF-----NTICDATQER 248
           D  KV   +QTT+   ET E              V+   E F +      + IC ATQ R
Sbjct: 179 DENKVIWLSQTTLSVDETMET-------------VQRLRERFPSLQDPPSDDICYATQNR 225

Query: 249 QDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPS-YWIDSEQRIGPGNRIAYKL 425
           Q A+  +  E  DL++V+G  NSSN+  L E+   +G  + + +D  + + P        
Sbjct: 226 QVAVKAMAPE-CDLVIVVGSRNSSNSVRLVEVALNAGAKAAHLVDYAREVDPA------- 277

Query: 426 NHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE 548
                     WL EG  TIG+TSGAS P+ +V   L  + E
Sbjct: 278 ----------WL-EGVRTIGITSGASVPEILVRGVLDMLAE 307
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>ISPH_CHLCV (Q822D9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 309

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/111 (30%), Positives = 59/111 (53%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           +++C ATQ RQ+A+   V  KV+ + VIG   SSN++ L+E+ E   IP+  ++S   I 
Sbjct: 192 SSVCYATQNRQEAL-RSVLPKVNFVYVIGDVQSSNSNRLREVAEKRNIPARLVNSPDHIS 250

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                          E  N+  +    I +T+GASTP+ +V+  + ++ E+
Sbjct: 251 D--------------EILNYSGD----IAITAGASTPEHIVQSCISRLKEL 283
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>ISPH_GLUOX (Q5FUH7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 336

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 43/149 (28%), Positives = 70/149 (46%), Gaps = 1/149 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D  K+    QTT+   +T EI  ++        G +  +        IC AT  RQ+A+ 
Sbjct: 179 DPTKLAFITQTTLSVDDTAEIVDILRSRFPLIEGPKRED--------ICYATTNRQEAVK 230

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +  E  DL++VIG  NSSN+  L+E+ E SG                  A +      +
Sbjct: 231 AIAPES-DLVIVIGSPNSSNSQRLREVAERSG------------------ARRALLVPKL 271

Query: 444 EAENW-LPEGPITIGVTSGASTPDKVVED 527
           E  +W + EG  T+G+++GAS P+ +V++
Sbjct: 272 ENLDWSVLEGVETLGISAGASAPESLVQE 300
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>ISPH_HAEIN (P44976) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 314

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 34/108 (31%), Positives = 54/108 (50%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           N IC AT  RQ+A+  L K   DL+LV+G  NSSN++ L E+    G+ S  +D    I 
Sbjct: 194 NDICYATTNRQEAVRELAKLS-DLVLVVGSKNSSNSNRLAELASRMGVKSQLLDEPADI- 251

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
                             +W  +   TIG+T+GAS P+++ +  + ++
Sbjct: 252 ----------------QADWFNDVK-TIGITAGASAPEELGQSIISRL 282
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>ISPH_DESVH (Q72G08) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 290

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 32/114 (28%), Positives = 56/114 (49%)
 Frame = +3

Query: 189 ENANEHFVAFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPS 368
           E          TICDAT+ RQ     + + KVD ++V+GG++S NT  L ++    G+ +
Sbjct: 189 ERLGHEVPVLETICDATRLRQQEAIDIAR-KVDAMVVVGGFDSGNTRRLADVAAAQGVFT 247

Query: 369 YWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDT 530
             +++E ++ P  ++                  G   IG+T+GASTP  +++ T
Sbjct: 248 VHVENESQL-PVEQL-----------------RGCGIIGLTAGASTPKSIIDAT 283
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>ISPH_EHRRG (Q5FFL5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 328

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 51/179 (28%), Positives = 81/179 (45%), Gaps = 5/179 (2%)
 Frame = +3

Query: 69  FDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQER 248
           FDPD    K+    QTT+   +T    K++   + +KF     N        IC ATQ R
Sbjct: 167 FDPD----KLAYVTQTTLSVDDT----KVIIDKLKKKF----PNIKGPDLKDICYATQNR 214

Query: 249 QDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLN 428
           Q     L  E VD++ ++G  NSSN++ L+E+  +    ++ IDS + I         LN
Sbjct: 215 QTTTKRLA-ELVDIVFILGSKNSSNSNRLKELAAIQ-TQAFLIDSYKEI--------DLN 264

Query: 429 HGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL-----HKVFEIKRQEVLQVA*IFS 590
                     L      IG+T+GAS PD +V+  +     H   ++   E++Q +  F+
Sbjct: 265 ----------LLNDITKIGITAGASAPDILVQQVIDFLKQHMKVKLSDLEIVQESVTFN 313
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>ISPH_CHLAB (Q5L5D3) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 309

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 32/111 (28%), Positives = 58/111 (52%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           +++C ATQ RQ+A+   V  +V+ + VIG   SSN++ L+E+ E   IP+  ++S   I 
Sbjct: 192 SSVCYATQNRQEAL-RAVLPRVNFVYVIGDVQSSNSNRLREVAEKRNIPARLVNSPDHIS 250

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEI 551
                       E++            I VT+GASTP+ +++  + ++ E+
Sbjct: 251 -----------DEILHYSG-------DIAVTAGASTPEHIIQSCISRLKEL 283
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>ISPH_LEPIN (Q8F3I3) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 330

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
 Frame = +3

Query: 111 QTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVDL 290
           QTT+   +T+ I   + KT      VE+ ++     + IC AT ERQ+A+  L+ +K+D 
Sbjct: 182 QTTLSVADTKNIIDQISKTFPF---VEHPSK-----DDICYATTERQEAV-SLMMDKIDA 232

Query: 291 ILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEG 470
           +LVIG  NSSN+  L ++ + S   S+ + +   +                 ++ ++   
Sbjct: 233 MLVIGADNSSNSLRLLQLAQKSKPHSFKVSTADDL-----------------SKEYIQNN 275

Query: 471 PITI-GVTSGASTPDKVVEDTLHKV 542
            I I G+T+GASTP  +V++ + K+
Sbjct: 276 EIKILGLTAGASTPQVLVDEIISKL 300
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>ISPH_LEPIC (Q72S57) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 330

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
 Frame = +3

Query: 111 QTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEKVDL 290
           QTT+   +T+ I   + KT      VE+ ++     + IC AT ERQ+A+  L+ +K+D 
Sbjct: 182 QTTLSVADTKNIIDQISKTFPF---VEHPSK-----DDICYATTERQEAV-SLMMDKIDA 232

Query: 291 ILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWLPEG 470
           +LVIG  NSSN+  L ++ + S   S+ + +   +                 ++ ++   
Sbjct: 233 MLVIGADNSSNSLRLLQLAQKSKPHSFKVSTADDL-----------------SKEYIQNN 275

Query: 471 PITI-GVTSGASTPDKVVEDTLHKV 542
            I I G+T+GASTP  +V++ + K+
Sbjct: 276 EIKILGLTAGASTPQVLVDEIISKL 300
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>ISPH_EHRRW (Q5HB13) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 328

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 51/179 (28%), Positives = 81/179 (45%), Gaps = 5/179 (2%)
 Frame = +3

Query: 69  FDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQER 248
           FDPD    K+    QTT+   +T    K++   + +KF     N        IC ATQ R
Sbjct: 167 FDPD----KLAYVTQTTLSVDDT----KVIIDKLKKKF----PNIKGPDLKDICYATQNR 214

Query: 249 QDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLN 428
           Q     L  E VD++ ++G  NSSN++ L+E+  +    ++ IDS + I         LN
Sbjct: 215 QTTTKRLA-ELVDIVFILGSKNSSNSNRLKELAGIQ-TQAFLIDSYKEI--------DLN 264

Query: 429 HGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL-----HKVFEIKRQEVLQVA*IFS 590
                     L      IG+T+GAS PD +V+  +     H   ++   E++Q +  F+
Sbjct: 265 ----------LLNDITKIGITAGASAPDILVQQVIDFLKQHMKVKLSDLEIVQESVTFN 313
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>ISPH_TREPA (O83558) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 376

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 41/145 (28%), Positives = 67/145 (46%)
 Frame = +3

Query: 87  LEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYH 266
           L +  +  QTT+ +GE + I     +T +R+  V           TIC AT  RQ A+  
Sbjct: 199 LARAALLAQTTITQGEYDAIAAAA-RTRVRELTVAR---------TICAATARRQAALRA 248

Query: 267 LVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIE 446
           L    V+ +LVIGG +S+NT  L      + +P++ ++  + I P     Y  +      
Sbjct: 249 LAPT-VEALLVIGGAHSANTQRLLHTARETSLPTWLVERVEDIPPD---IYAFS------ 298

Query: 447 AENWLPEGPITIGVTSGASTPDKVV 521
                      +G+++GASTPD V+
Sbjct: 299 ----------AVGISAGASTPDCVI 313
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>ISPH_CHLMU (Q9PL59) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 308

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 37/108 (34%), Positives = 57/108 (52%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           ++IC ATQ RQ A+ +++  KV+ + VIG   SSN++ L+ +    G+            
Sbjct: 192 SSICYATQNRQSALRNILP-KVEFVYVIGDPKSSNSNQLKAVAARRGV------------ 238

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
               +A  +N+ E I  E     G   IGVT+GASTP+ VV+  L K+
Sbjct: 239 ----VARLVNNPEEITDEILQYSG--NIGVTAGASTPEDVVQACLTKL 280
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>ISPH_BRUSU (Q8G257) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 346

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 1/151 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +G   QTT+   +T  I K ++            N    A  +IC AT  RQDA+ 
Sbjct: 165 DEDNLGFVTQTTLSVDDTAGIIKELQARF--------PNLAAPAAESICYATTNRQDAV- 215

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
                  DL L++G  NSSN+  L E+ E +G                R++  +   E I
Sbjct: 216 RAAAPGCDLFLIVGAPNSSNSKRLVEVAEKAGA---------------RMSMLVQRAEDI 260

Query: 444 EAENWLPEGPIT-IGVTSGASTPDKVVEDTL 533
           E   W   G I+ +G+++GAS P+ +V++ +
Sbjct: 261 E---WEQIGDISVVGLSAGASAPEIIVDEII 288
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>ISPH_BRUME (Q8YFR1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 346

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 1/151 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +G   QTT+   +T  I K ++            N    A  +IC AT  RQDA+ 
Sbjct: 165 DEDNLGFVTQTTLSVDDTAGIIKELQARF--------PNLAAPAAESICYATTNRQDAV- 215

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
                  DL L++G  NSSN+  L E+ E +G                R++  +   E I
Sbjct: 216 RAAAPGCDLFLIVGAPNSSNSKRLVEVAEKAGA---------------RMSMLVQRAEDI 260

Query: 444 EAENWLPEGPIT-IGVTSGASTPDKVVEDTL 533
           E   W   G I+ +G+++GAS P+ +V++ +
Sbjct: 261 E---WEQIGDISVVGLSAGASAPEIIVDEII 288
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>ISPH_BRUAB (Q57EP6) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 346

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 1/151 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +G   QTT+   +T  I K ++            N    A  +IC AT  RQDA+ 
Sbjct: 165 DEDNLGFVTQTTLSVDDTAGIIKELQARF--------PNLAAPAAESICYATTNRQDAV- 215

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
                  DL L++G  NSSN+  L E+ E +G                R++  +   E I
Sbjct: 216 RAAAPGCDLFLIVGAPNSSNSKRLVEVAEKAGA---------------RMSMLVQRAEDI 260

Query: 444 EAENWLPEGPIT-IGVTSGASTPDKVVEDTL 533
           E   W   G I+ +G+++GAS P+ +V++ +
Sbjct: 261 E---WEQIGDISVVGLSAGASAPEIIVDEII 288
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>ISPH_GEOKA (Q5KX24) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 42/150 (28%), Positives = 74/150 (49%), Gaps = 2/150 (1%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           E++ + NQTTM + +  +I        M K  V+    H      IC ATQ RQ+A+   
Sbjct: 162 ERIMVTNQTTMSQWDVADI--------MAK--VKEKYPHVEMHKEICLATQLRQEAVAEQ 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIE 446
            KE  D+ +V+G   S+N++ L ++  E++G  +Y            R+A      ++ E
Sbjct: 212 AKE-ADVTIVVGDPRSNNSNRLAQVSEEIAGTKAY------------RVA------DVTE 252

Query: 447 AE-NWLPEGPITIGVTSGASTPDKVVEDTL 533
            + NW+ +    + VT+GASTP  + ++ +
Sbjct: 253 IDINWIKDAK-KVAVTAGASTPTPITKEVI 281
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>ISPH_RHOBA (Q7ULU1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 319

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 41/155 (26%), Positives = 74/155 (47%)
 Frame = +3

Query: 69  FDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQER 248
           F+P   L  +    QTT+     ++ G+++ +   R   +     H    + IC ATQ R
Sbjct: 155 FEPGTQLAYL---TQTTL---SVDDAGRVIRRLRERFPEI-----HSPPKDDICYATQNR 203

Query: 249 QDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLN 428
           Q+A+  L++E  D+I+V+G  NSSN+  L+E+    G  +  +D     GP +    + +
Sbjct: 204 QEAV-KLLREDADVIVVLGSQNSSNSQRLKELAAEQGKRAMLVD-----GPQDLAVDQFS 257

Query: 429 HGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
             +              + +T+GAS P+ VV+ T+
Sbjct: 258 DDD-------------RVLITAGASAPESVVQSTI 279
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>ISPH_MYCPE (Q8EWR9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 299

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 42/136 (30%), Positives = 65/136 (47%)
 Frame = +3

Query: 102 IANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHLVKEK 281
           + NQTT+   E EEI     +T+  K+      ++    N IC+A ++RQDA+ ++  E 
Sbjct: 173 VTNQTTISIYEFEEI----TETLKSKY------KNIEFKNDICNAAKDRQDAVINMPSE- 221

Query: 282 VDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEAENWL 461
           VDL+LV+G   S+N+  L EIG    I S+ I + + I                  + W 
Sbjct: 222 VDLLLVVGDIKSNNSKKLVEIGIKKQIESHLIWNTKNI-----------------KDEWF 264

Query: 462 PEGPITIGVTSGASTP 509
                 + +TSG STP
Sbjct: 265 INKK-CLAITSGCSTP 279
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>ISPH1_BRAJA (Q89UU5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (EC|
           1.17.1.2)
          Length = 322

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 41/150 (27%), Positives = 67/150 (44%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D   +    QTT+   +T EI  L+++      G    +        IC AT  RQ A+ 
Sbjct: 163 DPNNLAFVTQTTLSIDDTAEIVALLKERFPNINGPHKED--------ICYATTNRQLAVK 214

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
             V   VD ++V+G  NSSN+  L+E+ E  G P               IA        +
Sbjct: 215 K-VAPVVDALIVVGAPNSSNSQRLREVAEREGCP---------------IAVLAQRAADL 258

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTL 533
           + + +  E   ++G+T+GAS P+ +VE+ +
Sbjct: 259 DWKRF--ENITSLGITAGASAPEVIVEEIM 286
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>ISPH_LISMO (P58676) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 331

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 41/150 (27%), Positives = 72/150 (48%), Gaps = 2/150 (1%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+ + NQTTM K +  ++   ++    +           +    IC ATQ RQ+A+   
Sbjct: 162 DKIFVTNQTTMSKWDVADLMHYIKGKFPKA----------IQHQEICMATQVRQEAVALQ 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIE 446
            K+  DL +V+G   S+NT+ L ++  E +G  +Y            RIA      ++ E
Sbjct: 212 AKD-ADLTIVVGDPRSNNTARLAQVSIEKAGTKAY------------RIA------DITE 252

Query: 447 AE-NWLPEGPITIGVTSGASTPDKVVEDTL 533
            +  W+ +    + VT+GASTP ++V + L
Sbjct: 253 LDIEWIKDAK-KVAVTAGASTPTQLVREVL 281
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>ISPH_BACHK (Q6HDN0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 1/153 (0%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           ++  +K+ + NQTTM + + + + + ++K    KF     ++       IC ATQ RQ+A
Sbjct: 158 EIPTDKILVTNQTTMSQWDVQHLMEDIQK----KFPTAEFHKE------ICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +     +  DL +V+G   S+N++ L ++  E++G  +Y +     I        KL   
Sbjct: 208 VAKQA-DVADLTIVVGDPKSNNSNRLAQVSQEIAGTKAYRVADVSEI--------KLE-- 256

Query: 435 ELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                  WL +G   + VT+GASTP  + ++ +
Sbjct: 257 -------WL-QGVENVAVTAGASTPTPITKEVI 281
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>ISPH_BACCZ (Q634Q0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 1/153 (0%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           ++  +K+ + NQTTM + + + + + ++K    KF     ++       IC ATQ RQ+A
Sbjct: 158 EIPTDKILVTNQTTMSQWDVQHLMEDIQK----KFPTAEFHKE------ICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +     +  DL +V+G   S+N++ L ++  E++G  +Y +     I        KL   
Sbjct: 208 VAKQA-DVADLTIVVGDPKSNNSNRLAQVSQEIAGTKAYRVADVSEI--------KLE-- 256

Query: 435 ELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                  WL +G   + VT+GASTP  + ++ +
Sbjct: 257 -------WL-QGVENVAVTAGASTPTPITKEVI 281
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>ISPH_BACC1 (Q730P8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 1/153 (0%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           ++  +K+ + NQTTM + + + + + ++K    KF     ++       IC ATQ RQ+A
Sbjct: 158 EIPTDKILVTNQTTMSQWDVQHLMEDIQK----KFPTAEFHKE------ICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +     +  DL +V+G   S+N++ L ++  E++G  +Y +     I        KL   
Sbjct: 208 VAKQA-DVADLTIVVGDPKSNNSNRLAQVSQEIAGTKAYRVADVSEI--------KLE-- 256

Query: 435 ELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                  WL +G   + VT+GASTP  + ++ +
Sbjct: 257 -------WL-QGVENVAVTAGASTPTPITKEVI 281
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>ISPH_BACAN (Q81LU9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 1/153 (0%)
 Frame = +3

Query: 78  DVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDA 257
           ++  +K+ + NQTTM + + + + + ++K    KF     ++       IC ATQ RQ+A
Sbjct: 158 EIPTDKILVTNQTTMSQWDVQHLMEDIQK----KFPTAEFHKE------ICLATQVRQEA 207

Query: 258 MYHLVKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHG 434
           +     +  DL +V+G   S+N++ L ++  E++G  +Y +     I        KL   
Sbjct: 208 VAKQA-DVADLTIVVGDPKSNNSNRLAQVSQEIAGTKAYRVADVSEI--------KLE-- 256

Query: 435 ELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                  WL +G   + VT+GASTP  + ++ +
Sbjct: 257 -------WL-QGVENVAVTAGASTPTPITKEVI 281
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>ISPH_AGRT5 (P58673) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 348

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 4/170 (2%)
 Frame = +3

Query: 81  VDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAM 260
           VD E +G   QTT+   +T      V   +  +F    A     A ++IC AT  RQDA+
Sbjct: 166 VDRENLGFVTQTTLSVDDTAG----VIARLQERFPAIQAP----AADSICYATTNRQDAV 217

Query: 261 YHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGEL 440
                   DL +V+G  NSSN+  L E+   +G                       H  L
Sbjct: 218 KQAAPG-CDLFIVVGAPNSSNSKRLVEVALRAG---------------------AKHSVL 255

Query: 441 IEAE---NWLPEGPI-TIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQVA 578
           ++     +W   G I T+G+++GAS P+ +V++ + + F+ +    L +A
Sbjct: 256 VQRASEIDWNEIGDIRTVGLSAGASAPEVIVDEII-EAFKARFDTTLDLA 304
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>ISPH_CHLPN (Q9Z6P2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 310

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 33/108 (30%), Positives = 56/108 (51%)
 Frame = +3

Query: 219 NTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIG 398
           ++IC AT  RQ A+   V  +V+ + V+G  NSSN++ L+E+    G+P+  I++ + I 
Sbjct: 192 SSICYATTNRQKAL-RSVLSRVNYVYVVGDVNSSNSNRLREVALRRGVPADLINNPEDID 250

Query: 399 PGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
                   +NH                I +T+GASTP+ VV+  + K+
Sbjct: 251 TN-----IVNHSG-------------DIAMTAGASTPEDVVQACIRKL 280
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>ISPH_THEMA (Q9X1F7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 275

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 46/155 (29%), Positives = 69/155 (44%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +KV   +QTT    E +E        M+R     N  E  V  NTIC  T  R+  +  L
Sbjct: 143 KKVVFLSQTTSSLEEYKEF----VAAMIRM----NEFEEAVFLNTICPVTVNREREVEEL 194

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
            K   DL +V+GG +SSNT  L  I       + WI+S   + P + + Y          
Sbjct: 195 SKI-CDLSIVVGGKHSSNTGKLFRIASKHS-KTIWIESPDEL-PADVVKYG--------- 242

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIK 554
                    T+ V SG STP+ ++E+ + K+ E++
Sbjct: 243 ---------TVCVFSGTSTPNSLIENVVRKLKEME 268
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>ISPH_BIFLO (Q8G4L8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 352

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 31/103 (30%), Positives = 57/103 (55%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ A+  LV ++ D ++++G  NSSN+  L E+            +++ +G  
Sbjct: 233 ICYATSNRQAAV-KLVAQQSDCVVIVGSANSSNSVRLMEV------------AQEGLGER 279

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
            + AY+++    ++   W  EG  ++G++SGAS PD++V   +
Sbjct: 280 GK-AYRVDDASELDPA-WF-EGLESVGISSGASVPDELVSGVI 319
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>ISPH_THET8 (Q5SMC8) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 340

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 44/153 (28%), Positives = 75/153 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D E+V +  QTT+   +T     +++K    K  V +  +       +C ATQ RQ+A+ 
Sbjct: 180 DPERVVVLTQTTLSVDDTLATIAILKKRFP-KLVVPSRKD-------LCYATQNRQEAVK 231

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +   KV+  LV+   +SSN   L E+            ++  +G     AY+L   E +
Sbjct: 232 RIAP-KVEAFLVLTSPHSSNGMRLLEL------------AQSLVGR----AYRLERPEEL 274

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
             E WL EG  ++G+TS ASTP+ +V+  + ++
Sbjct: 275 RPE-WL-EGVESLGITSAASTPEDLVQGVVDRL 305
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>ISPH_TROWT (Q83MR9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 322

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 43/148 (29%), Positives = 72/148 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+   +QTT+   ET E    V++  +R   +++        + IC ATQ RQ A+  +
Sbjct: 167 DKLVWLSQTTLSVDETLET---VKRLRLRFPHIQDPPS-----DDICYATQNRQAAVKKI 218

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
                DL++V+G  NSSN+  L E+                +  G + A +L++ +  E 
Sbjct: 219 APLS-DLVIVVGSANSSNSVRLVEVA---------------LENGAKAAVRLDYAD--EL 260

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTL 533
           +  L +    +GVTSGAS P+ +V D L
Sbjct: 261 DPALLDKVDVVGVTSGASVPEILVRDLL 288
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>ISPH_TROW8 (Q83NB2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 313

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 43/148 (29%), Positives = 72/148 (48%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           +K+   +QTT+   ET E    V++  +R   +++        + IC ATQ RQ A+  +
Sbjct: 158 DKLVWLSQTTLSVDETLET---VKRLRLRFPHIQDPPS-----DDICYATQNRQAAVKKI 209

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIEA 449
                DL++V+G  NSSN+  L E+                +  G + A +L++ +  E 
Sbjct: 210 APLS-DLVIVVGSANSSNSVRLVEVA---------------LENGAKAAVRLDYAD--EL 251

Query: 450 ENWLPEGPITIGVTSGASTPDKVVEDTL 533
           +  L +    +GVTSGAS P+ +V D L
Sbjct: 252 DPALLDKVDVVGVTSGASVPEILVRDLL 279
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>ISPH_THET2 (Q72G65) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 340

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 44/153 (28%), Positives = 75/153 (49%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D E+V +  QTT+   +T     +++K    K  V +  +       +C ATQ RQ+A+ 
Sbjct: 180 DPERVVVLTQTTLSVDDTLATIAILKKRFP-KLVVPSRKD-------LCYATQNRQEAVK 231

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
            +   KV+  LV+   +SSN   L E+            ++  +G     AY+L   E +
Sbjct: 232 RIAP-KVEAFLVLTSPHSSNGMRLLEL------------AQSLVGR----AYRLERPEEL 274

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTLHKV 542
             E WL EG  ++G+TS ASTP+ +V+  + ++
Sbjct: 275 RPE-WL-EGVESLGITSAASTPEDLVQGVVARL 305
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>ISPH_LISMF (Q71ZL9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 331

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 2/150 (1%)
 Frame = +3

Query: 90  EKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMYHL 269
           + + + NQTTM K +  ++   +++   +           +    IC ATQ RQ+A+   
Sbjct: 162 DNIFVTNQTTMSKWDVADLMDYIKEKFPKA----------IQHQEICMATQVRQEAVAVQ 211

Query: 270 VKEKVDLILVIGGWNSSNTSHLQEIG-ELSGIPSYWIDSEQRIGPGNRIAYKLNHGELIE 446
            K   DL +V+G   S+NT+ L ++  E +G  +Y            RIA      ++ E
Sbjct: 212 AKG-ADLTIVVGDPRSNNTARLAQVSIEKAGTKAY------------RIA------DITE 252

Query: 447 AE-NWLPEGPITIGVTSGASTPDKVVEDTL 533
            +  W+ +    + VT+GASTP ++V + L
Sbjct: 253 LDIEWIKDAK-KVAVTAGASTPTQLVREVL 281
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>ISPH2_RHOPA (Q6N1Y1) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (EC|
           1.17.1.2)
          Length = 320

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 31/103 (30%), Positives = 51/103 (49%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ A+   V   VD ++V+G  NSSN+  L+E+ E  G               
Sbjct: 201 ICYATTNRQAAVKK-VAPVVDAMIVVGAPNSSNSQRLREVAEREGC-------------- 245

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
            ++A  +     ++   +  EG   +G+T+GAS P+ +VE+ +
Sbjct: 246 -KVAVLVQRASDLDWSQF--EGIKVLGLTAGASAPEVIVEEIM 285
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>ISPH_BUCAI (P57247) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 319

 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 36/117 (30%), Positives = 58/117 (49%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           IC AT  RQ A+  L K   D+I VIG  NSSN++ L E+G+ +G  +  I S   I   
Sbjct: 196 ICYATTNRQIAVRQLSKI-ADIIFVIGSNNSSNSNRLAELGKETGTFTKLISSFLDI--- 251

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFEIKRQEVLQV 575
                          + WL +    IG+T+GAS P+ +V + +  + +I   + +++
Sbjct: 252 --------------KKKWL-KNVNYIGITAGASAPEILVTEVIQYLRKIGAHKPIEM 293
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>ISPH_RHIME (Q92RG2) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 350

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 39/151 (25%), Positives = 66/151 (43%), Gaps = 1/151 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +G   QTT+   +T  + K + +           N    A ++IC AT  RQ+A+ 
Sbjct: 182 DADNLGFVTQTTLSVDDTAGVIKRLHERF--------PNLTAPAADSICYATTNRQEAVK 233

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
                  DL LV+G  NSSN+  L E+                +  G + A  +     I
Sbjct: 234 QAAPG-CDLFLVVGAPNSSNSKRLVEVA---------------LRAGAKKAVLVQRASEI 277

Query: 444 EAENWLPEGPIT-IGVTSGASTPDKVVEDTL 533
           +   W   G I+ +G+++GAS P+ +V + +
Sbjct: 278 D---WSTVGDISMVGLSAGASAPEVIVNEII 305
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>ISPH_DEIRA (Q9RSG0) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 335

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/103 (31%), Positives = 54/103 (52%)
 Frame = +3

Query: 225 ICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPG 404
           +C AT+ RQDA+ ++    VD  LV+   +SSN   L E+ E     +Y +++   +   
Sbjct: 208 LCYATKNRQDAVKNIAPN-VDAFLVLTSTHSSNGMRLLELAEAECGRAYRLETAADL--- 263

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTL 533
            R+     +G+L         G  ++G+TS ASTPD +V+D +
Sbjct: 264 TRLE---QNGDL--------GGVRSVGITSAASTPDDLVQDVV 295
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>ISPH_SILPO (Q5LNJ7) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 316

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/150 (26%), Positives = 67/150 (44%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D  ++    QTT+   +T +I   ++    +  G    +        IC AT  RQ+A+ 
Sbjct: 160 DPARLAFVTQTTLSVDDTRDIVAALQARFPQIVGPHKED--------ICYATTNRQEAV- 210

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
             V  K D +LV+G  NSSN+  L E+   +G  SY     Q +   + I ++       
Sbjct: 211 KAVAPKSDALLVVGAPNSSNSRRLVEVAAKAGC-SY----AQLVQRADDIDWR------- 258

Query: 444 EAENWLPEGPITIGVTSGASTPDKVVEDTL 533
                  +G  TI V++GAS P+ +V + +
Sbjct: 259 -----ALDGIATIAVSAGASAPELLVNEVI 283
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>ISPH_BARHE (Q6G4C5) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 343

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 33/97 (34%), Positives = 49/97 (50%)
 Frame = +3

Query: 69  FDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQER 248
           + PD D + +G   QTT+   +T EI  +++    R+F          A  +IC AT  R
Sbjct: 160 YQPD-DPDNLGFVTQTTLSVEDTAEILDVLQ----RRFPALEPP----AAESICYATTNR 210

Query: 249 QDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSG 359
           Q+A+        DL L++G  NSSN+  L E+ E SG
Sbjct: 211 QNAVKAAALGS-DLFLIVGAPNSSNSRRLVEVAERSG 246
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>ISPH_BARQU (Q6G0C9) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 340

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 41/156 (26%), Positives = 73/156 (46%), Gaps = 1/156 (0%)
 Frame = +3

Query: 69  FDPDVDLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQER 248
           + PD D +K+G   QTT+   +T  I  +++    R+F          A  +IC AT  R
Sbjct: 160 YQPD-DPDKLGFVTQTTLSVEDTAGILDVLQ----RRFPALEPP----AAESICYATTNR 210

Query: 249 QDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLN 428
           Q+A+        DL L++G  NSSN+  L E+ E  G                R +  + 
Sbjct: 211 QNAVKAAALGS-DLFLIVGAPNSSNSRRLVEVAERFGA---------------RQSILVQ 254

Query: 429 HGELIEAENWLPEGPIT-IGVTSGASTPDKVVEDTL 533
             + I+ +     GP++ + +++GAS P+ +V++ +
Sbjct: 255 RADEIDFDRL---GPLSVVSLSAGASAPEIIVDEII 287
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>ISPH_RHILO (Q985W3) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC|
           1.17.1.2)
          Length = 336

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 39/151 (25%), Positives = 65/151 (43%), Gaps = 1/151 (0%)
 Frame = +3

Query: 84  DLEKVGIANQTTMLKGETEEIGKLVEKTMMRKFGVENANEHFVAFNTICDATQERQDAMY 263
           D + +G   QTT+   +T  I + + +           +    A  +IC AT  RQ+A+ 
Sbjct: 167 DPKALGFVTQTTLSVEDTAGIIRALRERF--------PDLQAPAAESICYATTNRQEAVK 218

Query: 264 HLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRIGPGNRIAYKLNHGELI 443
                  DL L++G  NSSN+  L E+ E +G     +       P N I          
Sbjct: 219 DTAPG-ADLYLIVGAPNSSNSRRLVEVAERAGATMSLLVQRAAEIPWNDI---------- 267

Query: 444 EAENWLPEGPI-TIGVTSGASTPDKVVEDTL 533
                   G I T+G+++GAS P+ +V++ +
Sbjct: 268 --------GTISTLGLSAGASAPEIIVDEII 290
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>LIFR_RAT (O70535) Leukemia inhibitory factor receptor precursor (LIF|
           receptor) (LIF-R) (CD118 antigen)
          Length = 1093

 Score = 34.7 bits (78), Expect = 0.32
 Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 8/90 (8%)
 Frame = +3

Query: 186 VENANEHFVAFNTICDATQERQDAM-----YHLVKEKV---DLILVIGGWNSSNTSHLQE 341
           +  AN   +++N  C +++E Q         H  + KV   D I+ +   NS+ +S   +
Sbjct: 557 INEANGKILSYNVSCSSSEETQSLSEILDPQHKAEIKVNKNDYIISVVARNSAGSSPPSK 616

Query: 342 IGELSGIPSYWIDSEQRIGPGNRIAYKLNH 431
           I  +  IP+  I  EQ +G GNRI     H
Sbjct: 617 IASME-IPNDDITVEQAVGIGNRIFLSWQH 645
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>RL10_FUSNN (Q8RHI4) 50S ribosomal protein L10|
          Length = 170

 Score = 33.9 bits (76), Expect = 0.54
 Identities = 38/149 (25%), Positives = 67/149 (44%), Gaps = 19/149 (12%)
 Frame = +3

Query: 30  EFLEKFKKAVSPGFDPDVDLEKVGIANQTTMLKGETEEIGK--LVEKTMMRKF-----GV 188
           E +EK KKA S  F   VD + + + N+ T+L+ +  E G   LV K  + K      GV
Sbjct: 12  ELVEKIKKAQSVVF---VDYQGIKV-NEETLLRKQMRENGAEYLVAKNRLFKIALKESGV 67

Query: 189 ENANEHFV--------AFNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEI 344
           E++ +  +         +N      +   D      K K+D+  + GG+ +     ++E+
Sbjct: 68  EDSFDEILEGSTAFAFGYNDPVAPAKAVFDLAKAKAKAKLDVFKIKGGYLTGKKVSVKEV 127

Query: 345 GELSGIPS----YWIDSEQRIGPGNRIAY 419
            EL+ +PS      +     +GP  ++AY
Sbjct: 128 EELAKLPSREQLLSMLLNSMLGPIRKLAY 156
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>LIFR_MOUSE (P42703) Leukemia inhibitory factor receptor precursor (LIF|
           receptor) (LIF-R) (D-factor/LIF receptor) (CD118
           antigen)
          Length = 1092

 Score = 33.5 bits (75), Expect = 0.71
 Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
 Frame = +3

Query: 186 VENANEHFVAFNTICDATQERQDAMY--------HLVKEKVDLILVIGGWNSSNTSHLQE 341
           +  AN   +++N  C   +E Q  +          +   K D I+ +   NS+ +S   +
Sbjct: 556 INEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSKNDYIISVVARNSAGSSPPSK 615

Query: 342 IGELSGIPSYWIDSEQRIGPGNRIAYKLNH 431
           I  +  IP+  I  EQ +G GNRI     H
Sbjct: 616 IASME-IPNDDITVEQAVGLGNRIFLTWRH 644
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>CH60_LACJO (Q9KJ23) 60 kDa chaperonin (Protein Cpn60) (groEL protein)|
          Length = 543

 Score = 32.3 bits (72), Expect = 1.6
 Identities = 25/83 (30%), Positives = 36/83 (43%), Gaps = 3/83 (3%)
 Frame = +3

Query: 396 GPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE--IKRQEVL 569
           G G   A  L    + E    +  G   +G+  G  T  K   D LHK+      + E+ 
Sbjct: 85  GDGTTTATVLTQAIVREGMKNVTAGANPVGIRRGIETATKAAVDELHKISHKVSTKDEIA 144

Query: 570 QVA*IFSKIGQ-GIIIADGLAKV 635
           QVA + S   + G +IAD + KV
Sbjct: 145 QVASVSSASTEVGNLIADAMEKV 167
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>RNP3_METMP (P60781) Ribonuclease P protein component 3 (EC 3.1.26.5) (RNase P|
           component 3)
          Length = 232

 Score = 31.6 bits (70), Expect = 2.7
 Identities = 25/82 (30%), Positives = 42/82 (51%), Gaps = 10/82 (12%)
 Frame = +3

Query: 243 ERQDAMYHLVKE---KVDLILVIGGWNSSNTSHLQ-------EIGELSGIPSYWIDSEQR 392
           + Q+ M   VK+   KVD++LV GG    N   L+          EL+ + +       R
Sbjct: 65  KNQNEMEKAVKKYRNKVDILLVEGGDVKINRRVLEMNDVDILSTPELNRMDNGLDHILAR 124

Query: 393 IGPGNRIAYKLNHGELIEAENW 458
           +G  NR+A +LN G L++++N+
Sbjct: 125 LGSTNRVAVELNFGNLLKSKNY 146
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>RPOL_PYRKO (Q5JE88) DNA-directed RNA polymerase subunit L (EC 2.7.7.6)|
          Length = 94

 Score = 30.8 bits (68), Expect = 4.6
 Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 7/63 (11%)
 Frame = +3

Query: 405 NRIAYKLNHGELIEAENWLPEGPITIG-------VTSGASTPDKVVEDTLHKVFEIKRQE 563
           N +   L+  E +    +  E PIT+        VT G  TP+K +E+   K+F+ + +E
Sbjct: 26  NLLTETLHENEHVTFAGYTIEHPITMARKPRFKVVTDGKITPEKALEEAAQKIFD-RARE 84

Query: 564 VLQ 572
           VL+
Sbjct: 85  VLE 87
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>CH60_LACZE (O32847) 60 kDa chaperonin (Protein Cpn60) (groEL protein) (HSP60)|
          Length = 544

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
 Frame = +3

Query: 396 GPGNRIAYKLNHGELIEAENWLPEGPITIGVTSGASTPDKVVEDTLHKVFE--IKRQEVL 569
           G G   A  L    + E    +  G   +G+ +G     K   D LHK+      ++E+ 
Sbjct: 85  GDGTTTATVLAQSIIREGMKNVTAGANPVGIRTGIEKATKAAVDELHKISHKVNGKKEIA 144

Query: 570 QVA*IFSKIGQ-GIIIADGLAKV 635
           QVA + S   + G +IAD + KV
Sbjct: 145 QVASVSSSNTEVGSLIADAMEKV 167
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>KIF4A_CHICK (Q90640) Chromosome-associated kinesin KIF4A (Chromokinesin)|
          Length = 1225

 Score = 30.0 bits (66), Expect = 7.8
 Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 3/48 (6%)
 Frame = +2

Query: 497 CLNSGQGCRGYATQGI*DQASRS---FAGCIDFQQNWSGDNNS*WPSK 631
           CL  G  CR  A+  +  Q+SRS   F  CID  Q    D NS + SK
Sbjct: 191 CLEQGNNCRTVASTAMNSQSSRSHAIFTICID--QKKKNDKNSSFHSK 236
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>DMD_PIG (Q5GN48) Dystrophin|
          Length = 3674

 Score = 30.0 bits (66), Expect = 7.8
 Identities = 33/144 (22%), Positives = 63/144 (43%), Gaps = 9/144 (6%)
 Frame = +3

Query: 216  FNTICDATQERQDAMYHLVKEKVDLILVIGGWNSSNTSHLQEIGELSGIPSYWIDSEQRI 395
            F  + DA++  Q  +  +V E V+   +       N+  + E  +L      W++ +   
Sbjct: 770  FRKLQDASRSAQALVEQMVNEGVNADSIKQAAEQLNSRWI-EFCQLLSERLNWLEYQ--- 825

Query: 396  GPGNRIAYKLNHGELIE-----AENWLPEGPITIGVTSGASTPDKVVEDTLHKVF----E 548
               NRI    N  + +E     AENWL   PIT    +   +  K+ +D ++++     +
Sbjct: 826  ---NRIITFYNQLQQLEQITTAAENWLKTQPITTSEPTAVKSQLKICKDEVNRLSALQPQ 882

Query: 549  IKRQEVLQVA*IFSKIGQGIIIAD 620
            I+R ++  +A    + GQG +  D
Sbjct: 883  IERLKIESIA--LKEKGQGPMFLD 904


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,017,806
Number of Sequences: 219361
Number of extensions: 2035584
Number of successful extensions: 5287
Number of sequences better than 10.0: 151
Number of HSP's better than 10.0 without gapping: 4942
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5095
length of database: 80,573,946
effective HSP length: 109
effective length of database: 56,663,597
effective search space used: 7706249192
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
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