ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal35j01 |
|---|---|
| Clone Library Name | barley_pub |
>KC12_YEAST (P23292) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 546 Score = 132 bits (333), Expect = 5e-31 Identities = 65/179 (36%), Positives = 113/179 (63%) Frame = +2 Query: 35 VALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDA 214 VA+KFE + ++ E++ Y IL G G+P+ +Y G++G + I+V+D+LG SL D Sbjct: 102 VAIKFEPRKTEAPQLKD--EYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDL 159 Query: 215 CCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDL 394 SV+ V +A++ I+++E +H+ ++ D+KP+NFL+G PG P+ K+ L+D Sbjct: 160 FDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDF 219 Query: 395 GLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 G+A ++++ T H+ Y ++ + GT RY S++ HLGR SRRDD+E++ + + LR Sbjct: 220 GMAKQYRDPKTKQHIPYREKKSL-SGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLR 277
>KC11_YEAST (P23291) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 538 Score = 131 bits (330), Expect = 1e-30 Identities = 66/181 (36%), Positives = 111/181 (61%) Frame = +2 Query: 29 VEVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 V VA+KFE + ++ E+K Y IL G +P +Y G++G + I+V+D+LG SL Sbjct: 93 VPVAIKFEPRKTEAPQLRD--EYKTYKILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLE 150 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D SV+ V +A++ I+++E +H+ ++ D+KP+NFL+G PG P+ + L+ Sbjct: 151 DLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLI 210 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 D G+A ++++ T H+ Y ++ + GT RY S++ HLGR SRRDD+E+L + + L Sbjct: 211 DFGMAKQYRDPKTKQHIPYREKKSL-SGTARYMSINTHLGREQSRRDDMEALGHVFFYFL 269 Query: 569 R 571 R Sbjct: 270 R 270
>KC1A_XENLA (P67963) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1A_MOUSE (Q8BK63) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1A_HUMAN (P48729) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1A_CHICK (P67962) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1A_SHEEP (P67829) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1A_RABIT (P67828) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1A_BOVIN (P67827) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 131 bits (330), Expect = 1e-30 Identities = 75/180 (41%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>KC1_TOXGO (Q6QNM1) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 131 bits (329), Expect = 2e-30 Identities = 73/180 (40%), Positives = 113/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E SK YE K+Y +L G G+P VH+ G +GDY +MV+D+LG SL D Sbjct: 34 EVAIKLESIKSKHPQL--LYESKLYKLLAGGIGIPMVHWYGIEGDYNVMVIDLLGPSLED 91 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 + +S++ V +A + ++ +E VHSK ++H D+KP+NFL+G + ++++D Sbjct: 92 LFSICNRKLSLKTVLMLADQMLNRIEFVHSKNFIHRDIKPDNFLIG--RGKKMSVVYIID 149 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLE+L Y L++ R Sbjct: 150 FGLAKKYRDPKTQQHIPYREGKNL-TGTARYASINTHLGIEQSRRDDLEALGYVLMYFNR 208
>CKI3_SCHPO (O74135) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 439 Score = 130 bits (328), Expect = 2e-30 Identities = 69/179 (38%), Positives = 111/179 (62%) Frame = +2 Query: 35 VALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDA 214 +ALKFE + S+ E+ Y +L G+ G+P V+Y G++G Y ++VMD+LG SL D Sbjct: 41 IALKFESRKSEVPQLRD--EYLTYKLLMGLPGIPSVYYYGQEGMYNLLVMDLLGPSLEDL 98 Query: 215 CCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDL 394 S + VA IA + I+ ++ VH + +++ D+KP+NFL+G PG+ E ++ VD Sbjct: 99 FDYCGRRFSPKTVAMIAKQMITRIQSVHERHFIYRDIKPDNFLIGFPGSKTENVIYAVDF 158 Query: 395 GLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 G+A ++++ T H Y++ + GT RY S++ HLGR SRRDDLES+ + ++ LR Sbjct: 159 GMAKQYRDPKTHVHRPYNEHKSL-SGTARYMSINTHLGREQSRRDDLESMGHVFMYFLR 216
>KC1AL_HUMAN (Q8N752) Casein kinase I isoform alpha-like (EC 2.7.11.1)| (CKI-alpha-like) (CK1) Length = 337 Score = 130 bits (326), Expect = 3e-30 Identities = 76/180 (42%), Positives = 111/180 (61%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + K YE K+Y IL G G+P +H+ G++ D ++VMD+LG SL D Sbjct: 42 EVAVKLESQKVKHPQL--LYESKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGT--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + + GTVRYAS++AHLG SRRDD+ESL Y ++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKHLI-GTVRYASINAHLGIEQSRRDDMESLGYVFMYFNR 216
>KC1A_RAT (P97633) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 130 bits (326), Expect = 3e-30 Identities = 75/180 (41%), Positives = 112/180 (62%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G+ DY ++VMD+LG SL D Sbjct: 42 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 100 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ R Sbjct: 158 FGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNR 216
>CKI2_SCHPO (P40234) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 435 Score = 129 bits (325), Expect = 4e-30 Identities = 69/179 (38%), Positives = 109/179 (60%) Frame = +2 Query: 35 VALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDA 214 +A+KFE K S+ E++ Y +L G G+P V+Y G++G + I+V+D+LG SL D Sbjct: 38 IAIKFEPKKSEAPQLRD--EYRTYKLLVGNAGIPNVYYFGQEGLHNILVIDLLGPSLEDL 95 Query: 215 CCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDL 394 SV+ VA A + +S ++ +H K V+ D+KP+NFL+G P + +++VD Sbjct: 96 FEWCGRRFSVKTVAMTAKQMLSRVQTIHEKNLVYRDIKPDNFLIGRPSSRNANMVYMVDF 155 Query: 395 GLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 G+A +++ T H+ Y +R + GT RY S++ HLGR SRRDDLESL + ++ LR Sbjct: 156 GMAKYYRDPKTKQHIPYSERKSL-SGTARYMSINTHLGREQSRRDDLESLGHVFMYFLR 213
>RAG8_KLULA (P40230) Casein kinase I homolog RAG8 (EC 2.7.11.1)| Length = 536 Score = 129 bits (325), Expect = 4e-30 Identities = 65/181 (35%), Positives = 110/181 (60%) Frame = +2 Query: 29 VEVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 V VA+KFE + + E++ Y IL G G+P+ +Y G++G + I+V+D+LG SL Sbjct: 101 VPVAIKFEPRKTDAPQLKD--EYRTYKILSGSEGIPQAYYFGQEGLHNILVIDLLGPSLE 158 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S++ V +AI+ I+++E++H ++ D+KP+NFL+G P P+ + L+ Sbjct: 159 DLFDWCGRRFSIKTVVHVAIQMITLIEELHDHDLIYRDIKPDNFLIGRPNQPDANMVHLI 218 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 D G+A +++ T H+ Y ++ + GT RY S++ HLGR SRRDD+E+L + + L Sbjct: 219 DFGMAKLYRDPKTKQHIPYREKKSL-SGTARYMSINTHLGREQSRRDDMEALGHVFFYFL 277 Query: 569 R 571 R Sbjct: 278 R 278
>KC1G3_HUMAN (Q9Y6M4) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 447 Score = 128 bits (322), Expect = 1e-29 Identities = 67/160 (41%), Positives = 100/160 (62%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E++ Y LG G+P+V+Y G G Y MV+++LG SL D T S++ V IAI+ Sbjct: 86 EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQ 145 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQ 451 IS +E VHSK ++ DVKPENFL+G PG ++ + ++D GLA ++ + T H+ Y + Sbjct: 146 LISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE 205 Query: 452 RPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 206 HKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 244
>KC1G3_RAT (Q62763) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 448 Score = 128 bits (322), Expect = 1e-29 Identities = 67/160 (41%), Positives = 100/160 (62%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E++ Y LG G+P+V+Y G G Y MV+++LG SL D T S++ V IAI+ Sbjct: 86 EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQ 145 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQ 451 IS +E VHSK ++ DVKPENFL+G PG ++ + ++D GLA ++ + T H+ Y + Sbjct: 146 LISRMEYVHSKNLIYRDVKPENFLIGRPGNKAQQVIHIIDFGLAKEYIDPETKKHIPYRE 205 Query: 452 RPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 206 HKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 244
>KC1G3_BOVIN (P35509) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) (Fragment) Length = 276 Score = 128 bits (322), Expect = 1e-29 Identities = 67/160 (41%), Positives = 100/160 (62%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E++ Y LG G+P+V+Y G G Y MV+++LG SL D T S++ V IAI+ Sbjct: 72 EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQ 131 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQ 451 IS +E VHSK ++ DVKPENFL+G PG ++ + ++D GLA ++ + T H+ Y + Sbjct: 132 LISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE 191 Query: 452 RPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 192 HKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 230
>KC1_PLAYO (Q7RBX5) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 128 bits (321), Expect = 1e-29 Identities = 67/161 (41%), Positives = 105/161 (65%) Frame = +2 Query: 89 YEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 YE K+Y ILGG GVP+V++ G +GD+ IMV+D+LG SL D + S++ V A Sbjct: 51 YESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTAD 110 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + ++ +E VHSK ++H D+KP+NFL+G + + ++D GLA K+++ + H+ Y Sbjct: 111 QMLNRIEYVHSKNFIHRDIKPDNFLIG--RGKKVTLIHIIDFGLAKKYRDSRSHTHIPYK 168 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + ++ GT RYAS++ HLG SRRDD+E+L Y L++ LR Sbjct: 169 EGKNL-TGTARYASINTHLGIEQSRRDDIEALGYVLMYFLR 208
>KC1_PLAF7 (Q8IHZ9) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 128 bits (321), Expect = 1e-29 Identities = 67/161 (41%), Positives = 105/161 (65%) Frame = +2 Query: 89 YEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 YE K+Y ILGG GVP+V++ G +GD+ IMV+D+LG SL D + S++ V A Sbjct: 51 YESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTAD 110 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + ++ +E VHSK ++H D+KP+NFL+G + + ++D GLA K+++ + H+ Y Sbjct: 111 QMLNRIEYVHSKNFIHRDIKPDNFLIG--RGKKVTLIHIIDFGLAKKYRDSRSHTHIPYK 168 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + ++ GT RYAS++ HLG SRRDD+E+L Y L++ LR Sbjct: 169 EGKNL-TGTARYASINTHLGIEQSRRDDIEALGYVLMYFLR 208
>KC1D_ARATH (P42158) Casein kinase I isoform delta-like (EC 2.7.11.1)| (CKI-delta) Length = 450 Score = 128 bits (321), Expect = 1e-29 Identities = 74/180 (41%), Positives = 114/180 (63%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 E+A+K E+ +K YE K+Y IL G GVP V + G +GDY ++VMD+LG SL D Sbjct: 34 ELAIKLENVKTKHPQL--LYESKLYRILQGGTGVPNVKWFGVEGDYNVLVMDLLGPSLED 91 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +S++ V +A + I+ +E HSK ++H D+KP+NFL+G +++++D Sbjct: 92 LFNFCSRKLSLKSVLMLADQMINRVEFFHSKSFLHRDLKPDNFLMGL--GRRANQVYIID 149 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ +T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ L+ Sbjct: 150 FGLAKKYRDSTTHQHIPYRENKNL-TGTARYASMNTHLGIEQSRRDDLESLGYILMYFLK 208
>KC1B_BOVIN (P35507) Casein kinase I isoform beta (EC 2.7.11.1) (CKI-beta)| Length = 336 Score = 127 bits (318), Expect = 3e-29 Identities = 73/180 (40%), Positives = 114/180 (63%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 +VA+K E ++++ +E ++Y+ L G G+P++ + G++ DY ++VMD+LG SL D Sbjct: 42 QVAVKLESENTR--QPRLLHEKELYNFLQGGVGIPQIRWYGQETDYNVLVMDLLGPSLED 99 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S S++ V +A + IS +E VHS+ +H D+KP+NFL+G P+ KKLFLVD Sbjct: 100 LFNFCSRRFSMKTVLMLADQMISRIEYVHSRNLIHRDIKPDNFLMGT--GPQWKKLFLVD 157 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ TG H+ + + F GT AS+ AHLG SRRDD+ES+ Y L++ R Sbjct: 158 FGLAKKYRDNRTGQHIPH-RSGKSFIGTPFCASISAHLGIEQSRRDDMESIGYVLMYFNR 216
>HHP1_SCHPO (P40235) Casein kinase I homolog hhp1 (EC 2.7.11.1)| Length = 365 Score = 126 bits (317), Expect = 4e-29 Identities = 75/180 (41%), Positives = 109/180 (60%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E +K YE++VY IL G G+P V + G + DY MVMD+LG SL D Sbjct: 36 EVAIKLESTRAKHPQL--EYEYRVYRILSGGVGIPFVRWFGVECDYNAMVMDLLGPSLED 93 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 + S++ V +A + IS +E +HSK ++H D+KP+NFL+G ++ ++D Sbjct: 94 LFNFCNRKFSLKTVLLLADQLISRIEFIHSKSFLHRDIKPDNFLMGI--GKRGNQVNIID 151 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y LV+ R Sbjct: 152 FGLAKKYRDHKTHLHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLVYFCR 210
>KC1G2_HUMAN (P78368) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 126 bits (316), Expect = 5e-29 Identities = 65/160 (40%), Positives = 99/160 (61%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E++ Y L GVP+V+Y G G Y MV+++LG SL D T +++ V IAI+ Sbjct: 89 EYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQ 148 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQ 451 I+ +E VH+K ++ DVKPENFL+G PGT + + ++D GLA ++ + T H+ Y + Sbjct: 149 LITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYRE 208 Query: 452 RPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 209 HKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 247
>KC1D_RAT (Q06486) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| Length = 415 Score = 126 bits (316), Expect = 5e-29 Identities = 72/178 (40%), Positives = 111/178 (62%), Gaps = 1/178 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E +K H + E K+Y ++ G G+P + + G +GDY +MVM++LG SL Sbjct: 34 EVAIKLECVKTK---HPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLE 90 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S S++ V +A + IS +E +HSK ++H DVKP+NFL+G + ++++ Sbjct: 91 DLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYII 148 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 D GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ Sbjct: 149 DFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLMY 205
>KC1D_MOUSE (Q9DC28) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 126 bits (316), Expect = 5e-29 Identities = 72/178 (40%), Positives = 111/178 (62%), Gaps = 1/178 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E +K H + E K+Y ++ G G+P + + G +GDY +MVM++LG SL Sbjct: 34 EVAIKLECVKTK---HPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLE 90 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S S++ V +A + IS +E +HSK ++H DVKP+NFL+G + ++++ Sbjct: 91 DLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYII 148 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 D GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ Sbjct: 149 DFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLMY 205
>KC1D_HUMAN (P48730) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 126 bits (316), Expect = 5e-29 Identities = 72/178 (40%), Positives = 111/178 (62%), Gaps = 1/178 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E +K H + E K+Y ++ G G+P + + G +GDY +MVM++LG SL Sbjct: 34 EVAIKLECVKTK---HPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLE 90 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S S++ V +A + IS +E +HSK ++H DVKP+NFL+G + ++++ Sbjct: 91 DLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYII 148 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 D GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ Sbjct: 149 DFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLMY 205
>YKL1_CAEEL (P42168) Putative casein kinase I C03C10.1 in chromosome III (EC| 2.7.11.1) Length = 341 Score = 126 bits (316), Expect = 5e-29 Identities = 76/181 (41%), Positives = 109/181 (60%), Gaps = 1/181 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPP-YEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E S H YE KVY IL G G+P + + G + +Y ++VMD+LG SL Sbjct: 41 EVAIKLE---SNRARHPQLLYESKVYRILQGGVGIPHIRWYGTEREYNVLVMDLLGPSLE 97 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S +++ V +A + I +E VH K ++H D+KP+NFL+G KLFL+ Sbjct: 98 DLFNFCSRRFTMKTVLMLADQMIGRIEYVHVKNFIHRDIKPDNFLMGI--GRHCNKLFLI 155 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 D GLA K+++ T H+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y L++ Sbjct: 156 DFGLAKKYRDSRTRTHIPYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVLMYFN 214 Query: 569 R 571 R Sbjct: 215 R 215
>CKI1_SCHPO (P40233) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 446 Score = 125 bits (315), Expect = 6e-29 Identities = 65/180 (36%), Positives = 109/180 (60%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 +VA+KFE + S E++ Y +L G G+P V+Y G++G + I+V+D+LG SL D Sbjct: 37 QVAIKFEPRRSDAPQLRD--EYRTYKLLAGCTGIPNVYYFGQEGLHNILVIDLLGPSLED 94 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 SV+ VA A + ++ ++ +H K V+ D+KP+NFL+G P + +++VD Sbjct: 95 LLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVD 154 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 G+ +++ T H+ Y ++ ++ GT RY S++ HLGR SRRDDLE+L + ++ LR Sbjct: 155 FGMVKFYRDPVTKQHIPYREKKNL-SGTARYMSINTHLGREQSRRDDLEALGHVFMYFLR 213
>HHP2_SCHPO (P40236) Casein kinase I homolog hhp2 (EC 2.7.11.1)| Length = 400 Score = 125 bits (313), Expect = 1e-28 Identities = 71/180 (39%), Positives = 105/180 (58%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 +VA+K E K H YE++VY+IL G G+P + + G Y MVMD+LG SL D Sbjct: 37 QVAVKLE--PLKARHHQLEYEFRVYNILKGNIGIPTIRWFGVTNSYNAMVMDLLGPSLED 94 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 C +++ V +A + IS +E VHSK ++H D+KP+NFL+ + ++D Sbjct: 95 LFCYCGRKFTLKTVLLLADQLISRIEYVHSKSFLHRDIKPDNFLM----KKHSNVVTMID 150 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T H+ Y ++ GT RYAS++ H+G SRRDDLESL Y L++ R Sbjct: 151 FGLAKKYRDFKTHVHIPYRDNKNL-TGTARYASINTHIGIEQSRRDDLESLGYVLLYFCR 209
>KC1G2_RAT (Q62762) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 124 bits (311), Expect = 2e-28 Identities = 64/160 (40%), Positives = 99/160 (61%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E++ Y L GVP+V+Y G G Y MV+++LG SL D T +++ V IAI+ Sbjct: 89 EYRFYKQLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQ 148 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQ 451 I+ +E VH+K ++ DVKPENFL+G PG+ + + ++D GLA ++ + T H+ Y + Sbjct: 149 LITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYRE 208 Query: 452 RPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 209 HKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 247
>KC1G2_MOUSE (Q8BVP5) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 124 bits (311), Expect = 2e-28 Identities = 64/160 (40%), Positives = 99/160 (61%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E++ Y L GVP+V+Y G G Y MV+++LG SL D T +++ V IAI+ Sbjct: 89 EYRFYKQLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQ 148 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQ 451 I+ +E VH+K ++ DVKPENFL+G PG+ + + ++D GLA ++ + T H+ Y + Sbjct: 149 LITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYRE 208 Query: 452 RPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 209 HKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 247
>KC1E_MOUSE (Q9JMK2) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 124 bits (311), Expect = 2e-28 Identities = 72/178 (40%), Positives = 110/178 (61%), Gaps = 1/178 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E +K H + E K Y ++ G G+P + + G +GDY +MVM++LG SL Sbjct: 34 EVAIKLECVKTK---HPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLE 90 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S S++ V +A + IS +E +HSK ++H DVKP+NFL+G + ++++ Sbjct: 91 DLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYII 148 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 D GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ Sbjct: 149 DFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLMY 205
>KC1E_HUMAN (P49674) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 124 bits (311), Expect = 2e-28 Identities = 72/178 (40%), Positives = 110/178 (61%), Gaps = 1/178 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E +K H + E K Y ++ G G+P + + G +GDY +MVM++LG SL Sbjct: 34 EVAIKLECVKTK---HPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLE 90 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S S++ V +A + IS +E +HSK ++H DVKP+NFL+G + ++++ Sbjct: 91 DLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYII 148 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 D GLA K+++ T H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ Sbjct: 149 DFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLMY 205
>KC1_PLAF4 (O15726) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 123 bits (308), Expect = 4e-28 Identities = 66/161 (40%), Positives = 103/161 (63%) Frame = +2 Query: 89 YEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 YE K+Y ILGG GVP+V++ G +GD+ IMV+D+LG SL D + S++ V A Sbjct: 51 YESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVRMTAD 110 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + ++ +E VHSK ++H D+KP+NFL+G + + ++D GLA K+++ + Y Sbjct: 111 QMLNRIEYVHSKNFIHRDIKPDNFLIG--RGKKVTLIHIIDFGLAKKYRDSRSHTSYPYK 168 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + ++ GT RYAS++ HLG SRRDD+E+L Y L++ LR Sbjct: 169 EGKNL-TGTARYASINTHLGIEQSRRDDIEALGYVLMYFLR 208
>KC1A_DROME (P54367) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (DmCK1) Length = 337 Score = 122 bits (307), Expect = 5e-28 Identities = 71/180 (39%), Positives = 109/180 (60%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E ++ YE K+Y IL G G PR+ + G++ ++ +VMD+LG SL D Sbjct: 45 EVAIKMESAHARHPQL--LYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLED 102 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 + +++ V + + I LE +H K ++H D+KP+NFL+G KLFL+D Sbjct: 103 LFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGI--GRHCNKLFLID 160 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GLA K+++ T HH+ Y + ++ GT RYAS++AHLG SRRDD+ESL Y +++ R Sbjct: 161 FGLAKKFRDPHTRHHIVYREDKNL-TGTARYASINAHLGIEQSRRDDMESLGYVMMYFNR 219
>KC1_EIMTE (Q6QNL9) Casein kinase I (EC 2.7.11.1)| Length = 335 Score = 122 bits (306), Expect = 7e-28 Identities = 72/183 (39%), Positives = 113/183 (61%), Gaps = 3/183 (1%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E S+ YE K+Y IL G G+P +++ G +GDY +M++++LG SL D Sbjct: 34 EVAIKLESVRSRHPQL--IYESKLYKILTGGIGIPTLYWYGIEGDYNVMIIELLGPSLED 91 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKL---F 382 + +S++ V +A + ++ +E VHS+ ++H D+KP+NFL+G KK+ F Sbjct: 92 LFSICNRKLSLKTVLMLADQMLNRIEFVHSRHFIHRDIKPDNFLIG-----RGKKMSIVF 146 Query: 383 LVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 +D GLA K+++ T H+ Y + ++ GT RYASV+ HLG SRRDDLE+L Y L++ Sbjct: 147 AIDFGLAKKYRDPRTQSHIPYREGKNL-TGTARYASVNTHLGIEQSRRDDLEALGYVLMY 205 Query: 563 LLR 571 R Sbjct: 206 FNR 208
>KC1G1_MOUSE (Q8BTH8) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 459 Score = 121 bits (303), Expect = 2e-27 Identities = 65/161 (40%), Positives = 99/161 (61%), Gaps = 1/161 (0%) Frame = +2 Query: 92 EWKVYDILGGI-HGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 E++ Y LG G+P+V+Y G G Y MV+++LG SL D T +++ V IAI Sbjct: 87 EYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI 146 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + +S +E VHSK ++ DVKPENFL+G G +E + ++D GLA ++ + T H+ Y Sbjct: 147 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYVDPETKKHIPYR 206 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 207 EHKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 246
>KC1G1_HUMAN (Q9HCP0) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 422 Score = 120 bits (302), Expect = 2e-27 Identities = 65/161 (40%), Positives = 99/161 (61%), Gaps = 1/161 (0%) Frame = +2 Query: 92 EWKVYDILGGI-HGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 E++ Y LG G+P+V+Y G G Y MV+++LG SL D T +++ V IAI Sbjct: 87 EYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI 146 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + +S +E VHSK ++ DVKPENFL+G G +E + ++D GLA ++ + T H+ Y Sbjct: 147 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 206 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 207 EHKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 246
>KC1G1_RAT (Q62761) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 390 Score = 120 bits (302), Expect = 2e-27 Identities = 65/161 (40%), Positives = 99/161 (61%), Gaps = 1/161 (0%) Frame = +2 Query: 92 EWKVYDILGGI-HGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 E++ Y LG G+P+V+Y G G Y MV+++LG SL D T +++ V IAI Sbjct: 87 EYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI 146 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + +S +E VHSK ++ DVKPENFL+G G +E + ++D GLA ++ + T H+ Y Sbjct: 147 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 206 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 + + GT RY S++ HLG+ SRRDDLE+L + ++ LR Sbjct: 207 EHKSL-TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 246
>DCO_DROME (O76324) Discs overgrown protein kinase (EC 2.7.11.1) (Protein| double-time) Length = 440 Score = 118 bits (295), Expect = 1e-26 Identities = 69/178 (38%), Positives = 110/178 (61%), Gaps = 1/178 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E +K H + E K Y + G G+PR+ + G +GDY +MVM++LG SL Sbjct: 34 EVAIKLECIRTK---HPQLHIESKFYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLE 90 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S S++ V +A + IS ++ +HS+ ++H D+KP+NFL+G + ++++ Sbjct: 91 DLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGL--GKKGNLVYII 148 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVF 562 D GLA K+++ + H+ Y + ++ GT RYAS++ HLG SRRDDLESL Y L++ Sbjct: 149 DFGLAKKFRDARSLKHIPYRENKNL-TGTARYASINTHLGIEQSRRDDLESLGYVLMY 205
>HRR25_YEAST (P29295) Casein kinase I homolog HRR25 (EC 2.7.11.1)| Length = 494 Score = 117 bits (292), Expect = 3e-26 Identities = 66/180 (36%), Positives = 104/180 (57%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E S+ YE +VY L G G+P + + GR+G+Y MV+D+LG SL D Sbjct: 34 EVAIKLESIRSRHPQLD--YESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLED 91 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S + V +A++ ++ +H + ++H D+KP+NFL+G + ++D Sbjct: 92 LFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGV--GRRGSTVHVID 149 Query: 392 LGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLLR 571 GL+ K+++ +T H+ Y + + GT RYASV+ HLG SRRDDLESL Y L++ + Sbjct: 150 FGLSKKYRDFNTHRHIPYRENKSL-TGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCK 208
>KIN20_CAEEL (Q20471) Casein kinase I isoform delta (EC 2.7.11.1) (Protein| kinase 20) Length = 497 Score = 110 bits (276), Expect = 2e-24 Identities = 66/181 (36%), Positives = 108/181 (59%), Gaps = 1/181 (0%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPY-EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 EVA+K E SK H + E ++Y I+ G G+P + + G++GDY +MVM++LG SL Sbjct: 216 EVAVKLECVKSK---HPQLHIESRLYRIMLGGIGIPEIRWCGQEGDYNVMVMELLGPSLE 272 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLV 388 D S++ V +A + +S +E +H + Y+H D+KP+NFL+G ++++ Sbjct: 273 DLFNFCQRKFSLKTVLLLADQMLSRVEFIHCRDYIHRDIKPDNFLMGL--GKRGNLVYII 330 Query: 389 DLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 D GLA ++++ S H+ Y + ++ GT RYAS++ H G SRRDD+ESL Y ++ Sbjct: 331 DFGLAKRYRD-SKHQHIAYRENKNL-TGTARYASINTHRGIEQSRRDDIESLGYVFMYFN 388 Query: 569 R 571 R Sbjct: 389 R 389
>KC13_YEAST (P39962) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 524 Score = 106 bits (264), Expect = 5e-23 Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 18/197 (9%) Frame = +2 Query: 35 VALKFE--HKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLW 208 VA+KFE H D+ E++ Y IL G G+P +Y G++G + I+++D+LG SL Sbjct: 57 VAIKFEPRHSDAPQLRD----EFRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLE 112 Query: 209 DACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL------LGPPG---- 358 D SV+ +A + I + +H ++ D+KP+NFL + P G Sbjct: 113 DLFEWCGRKFSVKTTCMVAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIK 172 Query: 359 ------TPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGS 520 + +++VD G+A ++++ T H+ Y +R + GT RY S++ H GR S Sbjct: 173 SCASSSNNDPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSL-SGTARYMSINTHFGREQS 231 Query: 521 RRDDLESLAYTLVFLLR 571 RRDDLESL + + LR Sbjct: 232 RRDDLESLGHVFFYFLR 248
>KC1A_PIG (O19175) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) (Fragment) Length = 125 Score = 86.7 bits (213), Expect = 4e-17 Identities = 51/127 (40%), Positives = 78/127 (61%) Frame = +2 Query: 32 EVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWD 211 EVA+K E + ++ YE K+Y IL G G+P + + G++ DY ++VMD+LG SL D Sbjct: 3 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 60 Query: 212 ACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVD 391 S +++ V +A + IS +E VH+K ++H D+KP+NFL+G KLFL+D Sbjct: 61 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLID 118 Query: 392 LGLATKW 412 GLA K+ Sbjct: 119 FGLAKKY 125
>VPK1_VACCC (P20505) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 81.6 bits (200), Expect = 1e-15 Identities = 46/139 (33%), Positives = 78/139 (56%), Gaps = 1/139 (0%) Frame = +2 Query: 146 YKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDV 325 YK +Y +V++ LG L N++ + V I IE ++ ++ +H +GY HGD+ Sbjct: 89 YKSINVEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDI 148 Query: 326 KPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRGTVRYASVHAH 502 K N +L ++ KL+LVD GL +K+ S G HV + + P+ + GT+ + + +H Sbjct: 149 KASNIVL---DQIDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203 Query: 503 LGRIGSRRDDLESLAYTLV 559 G + SRR DLE+L Y ++ Sbjct: 204 KGYVVSRRGDLETLGYCMI 222
>VPK1_VACCV (P16913) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 81.3 bits (199), Expect = 2e-15 Identities = 46/139 (33%), Positives = 78/139 (56%), Gaps = 1/139 (0%) Frame = +2 Query: 146 YKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDV 325 YK +Y +V++ LG L N++ + V I IE ++ ++ +H +GY HGD+ Sbjct: 89 YKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDI 148 Query: 326 KPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRGTVRYASVHAH 502 K N +L ++ KL+LVD GL +K+ S G HV + + P+ + GT+ + + +H Sbjct: 149 KASNIVL---DQIDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203 Query: 503 LGRIGSRRDDLESLAYTLV 559 G + SRR DLE+L Y ++ Sbjct: 204 KGYVVSRRGDLETLGYCMI 222
>VPK1_VACCA (O57252) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 81.3 bits (199), Expect = 2e-15 Identities = 46/139 (33%), Positives = 78/139 (56%), Gaps = 1/139 (0%) Frame = +2 Query: 146 YKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDV 325 YK +Y +V++ LG L N++ + V I IE ++ ++ +H +GY HGD+ Sbjct: 89 YKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDI 148 Query: 326 KPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRGTVRYASVHAH 502 K N +L ++ KL+LVD GL +K+ S G HV + + P+ + GT+ + + +H Sbjct: 149 KASNIVL---DQIDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203 Query: 503 LGRIGSRRDDLESLAYTLV 559 G + SRR DLE+L Y ++ Sbjct: 204 KGYVVSRRGDLETLGYCMI 222
>V212_FOWPV (Q9J523) Probable serine/threonine-protein kinase FPV212 (EC| 2.7.11.1) Length = 303 Score = 81.3 bits (199), Expect = 2e-15 Identities = 51/149 (34%), Positives = 81/149 (54%), Gaps = 5/149 (3%) Frame = +2 Query: 128 GVPRVHYKG----RQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKV 295 G+P H G + +Y ++ LG L + + ++ ++ +AI+ + IL+ + Sbjct: 93 GIPSFHGFGITIYKNVEYRFAIIQRLGRDL-ENILSEKEKFNITVIKKLAIKILDILKFI 151 Query: 296 HSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRP-DIFRG 472 HSK + HGD+K N L G ++ K++LVD GLATK+ S G H EY P + G Sbjct: 152 HSKEFSHGDIKAGNILFG----KDDDKVYLVDYGLATKYS--SNGKHKEYTINPKNRHNG 205 Query: 473 TVRYASVHAHLGRIGSRRDDLESLAYTLV 559 T+ + S+ AH G SRR DLESL + ++ Sbjct: 206 TMAFTSIDAHKGVTVSRRGDLESLGFCML 234
>VPK1_VARV (P33800) Serine/threonine-protein kinase 1 (EC 2.7.11.1)| Length = 300 Score = 80.1 bits (196), Expect = 4e-15 Identities = 44/139 (31%), Positives = 78/139 (56%), Gaps = 1/139 (0%) Frame = +2 Query: 146 YKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDV 325 YK +Y +V++ LG L N++ + V + IE ++ ++ +H +GY HG++ Sbjct: 89 YKSINTEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLVGIEILNTIQFMHEQGYSHGNI 148 Query: 326 KPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRGTVRYASVHAH 502 K N +L ++ KL+LVD GL +K+ S G HV + + P+ + GT+ + + +H Sbjct: 149 KASNIVL---DQMDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203 Query: 503 LGRIGSRRDDLESLAYTLV 559 G + SRR DLE+L Y ++ Sbjct: 204 KGYVVSRRGDLETLGYCMI 222
>TTBK2_MOUSE (Q3UVR3) Tau-tubulin kinase 2| Length = 1243 Score = 76.3 bits (186), Expect = 6e-14 Identities = 54/142 (38%), Positives = 77/142 (54%), Gaps = 6/142 (4%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSH-TMSVEMVACIAIEAISILEKVHSKGYVHGDVK 328 GR + +VM + G +L D + S T ++ + + + +E +HS G++H D+K Sbjct: 84 GRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIK 143 Query: 329 PENFLLGP-PGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI----FRGTVRYASV 493 P NF +G P T +K F++D GLA ++ S G D RP FRGTVRYAS+ Sbjct: 144 PSNFAMGRFPSTC--RKCFMLDFGLARQFTN-SCG-----DVRPPRAVAGFRGTVRYASI 195 Query: 494 HAHLGRIGSRRDDLESLAYTLV 559 +AH R R DDL SL Y LV Sbjct: 196 NAHRNREMGRHDDLWSLFYMLV 217
>VRK2_HUMAN (Q86Y07) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 508 Score = 75.9 bits (185), Expect = 8e-14 Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 3/176 (1%) Frame = +2 Query: 41 LKFEHKDSKGCSHGPPYEWKVYDILGG--IHGVPRVHYKGRQGDYFIMVMDMLGFSLWDA 214 LKF + +K E K D LG +G +KGR Y MVM+ LG L Sbjct: 74 LKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRS--YRFMVMERLGIDLQKI 131 Query: 215 CCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDL 394 N T V + I + +LE +H YVHGD+K N LL G +++L D Sbjct: 132 SGQNG-TFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL---GYKNPDQVYLADY 187 Query: 395 GLATKWKERSTGHHVEYDQRP-DIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLV 559 GL+ ++ G+H +Y + P GT+ + S+ AH G SRR D+E L Y ++ Sbjct: 188 GLS--YRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCML 241
>TTBK2_HUMAN (Q6IQ55) Tau-tubulin kinase 2 (EC 2.7.11.1)| Length = 1244 Score = 75.1 bits (183), Expect = 1e-13 Identities = 53/142 (37%), Positives = 77/142 (54%), Gaps = 6/142 (4%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSH-TMSVEMVACIAIEAISILEKVHSKGYVHGDVK 328 GR + +VM + G +L D + S T ++ + + + +E +HS G++H D+K Sbjct: 84 GRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIK 143 Query: 329 PENFLLGP-PGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI----FRGTVRYASV 493 P NF +G P T +K +++D GLA ++ S G D RP FRGTVRYAS+ Sbjct: 144 PSNFAMGRFPSTC--RKCYMLDFGLARQFTN-SCG-----DVRPPRAVAGFRGTVRYASI 195 Query: 494 HAHLGRIGSRRDDLESLAYTLV 559 +AH R R DDL SL Y LV Sbjct: 196 NAHRNREMGRHDDLWSLFYMLV 217
>VRK1_HUMAN (Q99986) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 396 Score = 75.1 bits (183), Expect = 1e-13 Identities = 51/149 (34%), Positives = 72/149 (48%), Gaps = 5/149 (3%) Frame = +2 Query: 128 GVPRVHYKGRQG----DYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKV 295 GVP+ G Y M+MD G L N+ S + V +++ + ILE + Sbjct: 109 GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYI 168 Query: 296 HSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRG 472 H YVHGD+K N LL +++LVD GLA ++ G H EY + P G Sbjct: 169 HEHEYVHGDIKASNLLL---NYKNPDQVYLVDYGLAYRYCPE--GVHKEYKEDPKRCHDG 223 Query: 473 TVRYASVHAHLGRIGSRRDDLESLAYTLV 559 T+ + S+ AH G SRR DLE L Y ++ Sbjct: 224 TIEFTSIDAHNGVAPSRRGDLEILGYCMI 252
>VRK1_MOUSE (Q80X41) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK) Length = 440 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/149 (34%), Positives = 72/149 (48%), Gaps = 5/149 (3%) Frame = +2 Query: 128 GVPRVHYKGRQG----DYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKV 295 GVP+ G Y M+MD G L N+ S + V +++ + ILE + Sbjct: 109 GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYI 168 Query: 296 HSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRG 472 H YVHGD+K N LL + ++LVD GLA ++ G H EY + P G Sbjct: 169 HEHEYVHGDIKASNLLLSHKNPDQ---VYLVDYGLA--YRYCPDGVHKEYKEDPKRCHDG 223 Query: 473 TVRYASVHAHLGRIGSRRDDLESLAYTLV 559 T+ + S+ AH G SRR DLE L Y ++ Sbjct: 224 TLEFTSIDAHKGVAPSRRGDLEILGYCMI 252
>TTBK1_HUMAN (Q5TCY1) Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau| kinase) Length = 1321 Score = 74.3 bits (181), Expect = 2e-13 Identities = 53/142 (37%), Positives = 77/142 (54%), Gaps = 6/142 (4%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSH-TMSVEMVACIAIEAISILEKVHSKGYVHGDVK 328 GR + +VM + G +L D + T ++ + + + +E +HS G++H D+K Sbjct: 97 GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIK 156 Query: 329 PENFLLGP-PGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI----FRGTVRYASV 493 P NF +G P T +K +++D GLA ++ +TG D RP FRGTVRYASV Sbjct: 157 PSNFAMGRLPST--YRKCYMLDFGLARQYTN-TTG-----DVRPPRNVAGFRGTVRYASV 208 Query: 494 HAHLGRIGSRRDDLESLAYTLV 559 +AH R R DDL SL Y LV Sbjct: 209 NAHKNREMGRHDDLWSLFYMLV 230
>VRK1_BRARE (Q7ZUS1) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 425 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/132 (34%), Positives = 64/132 (48%), Gaps = 1/132 (0%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 Y MVMD G L N S ++V + + + ILE +H YVH D+K N LL Sbjct: 127 YRFMVMDRFGTDLQKLFEGNGKKFSRKLVLQLGLRLLDILEYIHDHEYVHADIKASNLLL 186 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD-IFRGTVRYASVHAHLGRIGSR 523 ++FLVD GLA ++ G EY + P GT+ + S+ AH G SR Sbjct: 187 ---SYTNPNQVFLVDYGLAYRYAPE--GVPKEYKEDPKRCHDGTIEFTSIDAHKGVSPSR 241 Query: 524 RDDLESLAYTLV 559 R DLE + Y ++ Sbjct: 242 RADLEIMGYCMI 253
>YMX8_CAEEL (P34516) Putative serine/threonine-protein kinase K06H7.1 (EC| 2.7.11.1) Length = 346 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 1/136 (0%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKP 331 G++ Y MVM +LG SL + ++V I I + +++VH GY+H D+KP Sbjct: 85 GKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKP 144 Query: 332 ENFLLGPPGTPEEKKLFLVDLGLATKW-KERSTGHHVEYDQRPDIFRGTVRYASVHAHLG 508 N +G G+ +E+ ++D GLA ++ + G + + FRGT RY SV H Sbjct: 145 ANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCSVAMHDR 204 Query: 509 RIGSRRDDLESLAYTL 556 R DDL +L Y L Sbjct: 205 YEQGRVDDLWALVYIL 220
>VRK2_MOUSE (Q8BN21) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 503 Score = 70.5 bits (171), Expect = 3e-12 Identities = 47/149 (31%), Positives = 73/149 (48%), Gaps = 1/149 (0%) Frame = +2 Query: 125 HGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSK 304 +G +KGR Y MVM+ LG L N + ++ + I + +LE +H Sbjct: 104 YGFGLTDFKGRS--YRFMVMERLGIDLQKLLDQNGGFKKLTVLQ-LGIRMLDVLEYIHEN 160 Query: 305 GYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRP-DIFRGTVR 481 YVHGD+K N LL +++L D GL+ ++ G+H +Y + P GT+ Sbjct: 161 EYVHGDIKAANLLL---DFTNPDRVYLADYGLS--YRYCPNGNHKQYQEDPRKGHNGTIE 215 Query: 482 YASVHAHLGRIGSRRDDLESLAYTLVFLL 568 + S+ AH G SRR D+E L Y ++ L Sbjct: 216 FTSLDAHKGVAPSRRSDVEILGYCMLHWL 244
>NHK1_DROME (Q7KRY6) Nucleosomal histone kinase 1 (EC 2.7.11.1) (Protein| baellchen) Length = 599 Score = 66.2 bits (160), Expect = 6e-11 Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPP 355 +VM G L N + V +AI+ + + + +HS GYVH D+K N LLG Sbjct: 135 IVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLE 194 Query: 356 GTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD---IFRGTVRYASVHAHLGRIGSRR 526 + +LVD GLA+ H V D +PD + GT+ Y S AHLG + +RR Sbjct: 195 -KGGAAQAYLVDFGLAS--------HFVTGDFKPDPKKMHNGTIEYTSRDAHLG-VPTRR 244 Query: 527 DDLESLAYTLV 559 DLE L Y L+ Sbjct: 245 ADLEILGYNLI 255
>KC1D_RABIT (P81123) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) (Fragment) Length = 81 Score = 66.2 bits (160), Expect = 6e-11 Identities = 33/78 (42%), Positives = 51/78 (65%) Frame = +2 Query: 329 PENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLG 508 P+NFL+G + ++++D GLA K+++ T H+ Y + ++ GT RYAS++ HLG Sbjct: 4 PDNFLMGLG--KKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTHLG 60 Query: 509 RIGSRRDDLESLAYTLVF 562 SRRDDLESL Y L++ Sbjct: 61 IEQSRRDDLESLGYVLMY 78
>KRB2_VACCC (P21098) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 64.3 bits (155), Expect = 2e-10 Identities = 48/145 (33%), Positives = 72/145 (49%), Gaps = 2/145 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLG--FSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSK 304 +P ++ G DY V+ LG F+ D T SV AC+ + I+ LE +HS+ Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVFAPKD-------TESV-FEACVTM--INTLEFIHSR 133 Query: 305 GYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRY 484 G+ HG ++P N L+ K+L L+D K +S H++Y++ I G + Y Sbjct: 134 GFTHGKIEPRNILI------RNKRLSLIDYSRTNK-LYKSGNSHIDYNE-DMITSGNINY 185 Query: 485 ASVHAHLGRIGSRRDDLESLAYTLV 559 V HLG SRR DLE L Y ++ Sbjct: 186 MCVDNHLGATVSRRGDLEMLGYCMI 210
>KRB2_VACCV (P24362) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 63.9 bits (154), Expect = 3e-10 Identities = 48/145 (33%), Positives = 72/145 (49%), Gaps = 2/145 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLG--FSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSK 304 +P ++ G DY V+ LG F+ D T SV AC+ + I+ LE +HS+ Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVFAPKD-------TESV-FEACVTM--INTLEFIHSQ 133 Query: 305 GYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRY 484 G+ HG ++P N L+ K+L L+D K +S H++Y++ I G + Y Sbjct: 134 GFTHGKIEPRNILI------RNKRLSLIDYSRTNK-LYKSGNSHIDYNE-DMITSGNINY 185 Query: 485 ASVHAHLGRIGSRRDDLESLAYTLV 559 V HLG SRR DLE L Y ++ Sbjct: 186 MCVDNHLGATVSRRGDLEMLGYCMI 210
>YQI1_CAEEL (Q09503) Hypothetical protein C45G9.1 in chromosome III| Length = 290 Score = 63.9 bits (154), Expect = 3e-10 Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 14/159 (8%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNN---SHTMSVEMVACIAIEAISILEKVHS 301 +P ++ G++ ++ MVM +LG +L D N + S + + I+ + L+ VH Sbjct: 18 IPNLNLYGKKMNFSYMVMTLLGRNLQDLESTNFVVNKGFSRGTWSRVGIQWVYALKYVHY 77 Query: 302 KGYVHGDVKPENFLLGPPGTPEEKKLF-LVDLGLA----------TKWKERSTGHHVEYD 448 G++H +V +N LG E K+ ++D GL KW R H E Sbjct: 78 NGFIHRNVNTQNLFLGNEKDSERAKIIHILDFGLGRPFARYHARENKWIVRIARHSAE-- 135 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFL 565 FRG+ RYAS + HL + R DD+ SL Y ++ L Sbjct: 136 -----FRGSFRYASPNVHLRKEQGRVDDVWSLPYVIIEL 169
>KRB2_VACCA (O57259) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 63.2 bits (152), Expect = 5e-10 Identities = 47/145 (32%), Positives = 72/145 (49%), Gaps = 2/145 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLG--FSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSK 304 +P ++ G DY V+ LG F+ D T SV AC+ + I+ LE +HS+ Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVFAPKD-------TESV-FEACVTM--INTLEFIHSR 133 Query: 305 GYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRY 484 G+ HG ++P N L+ K+L L+D K +S H++Y++ I G + Y Sbjct: 134 GFTHGKIEPRNILI------RNKRLSLIDYSRTNK-LYKSGNSHIDYNE-DMITSGNINY 185 Query: 485 ASVHAHLGRIGSRRDDLESLAYTLV 559 V HLG S+R DLE L Y ++ Sbjct: 186 MCVDNHLGATVSKRGDLEMLGYCMI 210
>V226_FOWPV (Q9J509) Probable serine/threonine-protein kinase FPV226 (EC| 2.7.11.1) Length = 292 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/105 (34%), Positives = 58/105 (55%), Gaps = 1/105 (0%) Frame = +2 Query: 248 MVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 ++ I + + LE +H G HGD+KPEN ++ + +L+D G+ + + Sbjct: 123 LIKNIMKDMLYTLEYIHEHGISHGDIKPENIMVDG-----RYRSYLIDYGIVSYFIVN-- 175 Query: 428 GHHVEY-DQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLV 559 G HV+Y + + RGT+ YAS+ AH G +RR DLESL Y ++ Sbjct: 176 GKHVKYYKESKNWHRGTLYYASLDAHNGTCVTRRGDLESLGYCML 220
>YKL2_CAEEL (P42169) Putative casein kinase I C03C10.2 in chromosome III (EC| 2.7.11.1) Length = 363 Score = 59.3 bits (142), Expect = 7e-09 Identities = 43/142 (30%), Positives = 68/142 (47%), Gaps = 1/142 (0%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNS-HTMSVEMVACIAIEAISILEKVHSKG 307 +P ++ G + ++M +L ++ D + +S E V IA + ++ L+ +H G Sbjct: 131 IPTMYASGFNDQFNFIIMQLLSMNVGDFRKRSPLGRLSKETVGRIAYQTLNALKDIHDMG 190 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYA 487 YVH DVKP N G L+L+D GL ++K S G + + F+GT RY Sbjct: 191 YVHRDVKPANICFG-VHAQNRHILYLLDFGLVRRFKTES-GVCIPWRINAG-FKGTERYV 247 Query: 488 SVHAHLGRIGSRRDDLESLAYT 553 SV H + DD S+ YT Sbjct: 248 SVRVHEKLEQTPWDDAFSVLYT 269
>VRK3_HUMAN (Q8IV63) Serine/threonine-protein kinase VRK3 (EC 2.7.11.1)| (Vaccinia-related kinase 3) Length = 474 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/136 (30%), Positives = 65/136 (47%), Gaps = 2/136 (1%) Frame = +2 Query: 158 QGDYFIMVMDMLGFSLWDAC-CNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPE 334 Q Y +V+ LG SL A + H +S V +A + LE +H YVHG+V E Sbjct: 251 QDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAE 310 Query: 335 NFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEY-DQRPDIFRGTVRYASVHAHLGR 511 N + P ++ ++ L G A ++ +G HV Y + G + + S+ H G Sbjct: 311 NIFVDPE---DQSQVTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGC 365 Query: 512 IGSRRDDLESLAYTLV 559 SRR DL+SL Y ++ Sbjct: 366 GPSRRSDLQSLGYCML 381
>VRK3_MOUSE (Q8K3G5) Serine/threonine-protein kinase VRK3 (EC 2.7.11.1)| (Vaccinia-related kinase 3) Length = 453 Score = 53.9 bits (128), Expect = 3e-07 Identities = 41/136 (30%), Positives = 63/136 (46%), Gaps = 2/136 (1%) Frame = +2 Query: 158 QGDYFIMVMDMLGFSLWDACCNN-SHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPE 334 Q Y +V LG SL A +N H +S V +A + LE +H YVHG++ E Sbjct: 230 QDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAE 289 Query: 335 NFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRP-DIFRGTVRYASVHAHLGR 511 N + P + ++ LV G ++ G HV Y + G + + S+ H G Sbjct: 290 NVFVNPE---DLSQVTLVGYGFTYRYCPG--GKHVAYKEGSRSPHDGDLEFISMDLHKGC 344 Query: 512 IGSRRDDLESLAYTLV 559 SRR DL++L Y ++ Sbjct: 345 GPSRRSDLQTLGYCML 360
>KKR1_YEAST (P36003) Probable serine/threonine-protein kinase YKL171W (EC| 2.7.11.1) Length = 928 Score = 48.1 bits (113), Expect = 2e-05 Identities = 22/64 (34%), Positives = 39/64 (60%) Frame = +2 Query: 260 IAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV 439 ++++ +S L+ +HSK VHGD+K EN LL G + K+FL D G++ + E+ + Sbjct: 560 LSLQLLSALKYMHSKTIVHGDIKLENCLLQKEGKKSDWKVFLCDFGMSCHFDEKHVYRND 619 Query: 440 EYDQ 451 +D+ Sbjct: 620 TFDE 623
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 47.4 bits (111), Expect = 3e-05 Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 1/176 (0%) Frame = +2 Query: 44 KFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDML-GFSLWDACC 220 KF+ + S P +YD+ G++GD + +VM+ + G +L + Sbjct: 54 KFKRESQAAASLSHPNIVGIYDV-------------GQEGDIYYIVMEYVKGRTLKELIR 100 Query: 221 NNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGL 400 N + V+ IA + L+ H +H D+KP+N L+ +E + + D G+ Sbjct: 101 ENGGPLEVKRAVEIASQVCRALDHAHKNKIIHRDIKPQNILV-----TDEDVVKVTDFGI 155 Query: 401 ATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 A + G + Y D+ GT Y S G I R D+ SL L +L Sbjct: 156 A----RAANGATITY--TGDVI-GTAYYFSPEQAKGSIVDERTDIYSLGIVLFEML 204
>SPKF_SYNY3 (P73469) Serine/threonine-protein kinase F (EC 2.7.11.1)| Length = 495 Score = 45.8 bits (107), Expect = 8e-05 Identities = 35/139 (25%), Positives = 60/139 (43%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKP 331 G+Q +F +V + + + +S V + E + IL VH G +H D+KP Sbjct: 131 GKQDQFFYLVQEFINGQDLEKTVEKHGPLSEAEVRWVLTEMLKILSFVHGTGAIHRDIKP 190 Query: 332 ENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGR 511 N + +E KL+L+D G K+ + G + I+ ++ +A G Sbjct: 191 SNLM-----RDQEGKLYLLDFGAV---KQATAGVGASNEGSTGIY--SMGFAPPEQMAGN 240 Query: 512 IGSRRDDLESLAYTLVFLL 568 DL +LA T ++LL Sbjct: 241 QVYPATDLYALAVTCLYLL 259
>YOO1_CAEEL (P34633) Putative serine/threonine-protein kinase ZK507.1 (EC| 2.7.11.1) Length = 331 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/101 (28%), Positives = 48/101 (47%) Frame = +2 Query: 266 IEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEY 445 ++ + + H G++H D+KP N+ +G E ++++D GLA K+ R V Sbjct: 98 LQTMKAIHDFHQIGFLHRDIKPANYCIGYGSKSE--TIYVLDFGLARKY--RLPNGQVRP 153 Query: 446 DQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 + GT RY S +H RRDD ES + + L+ Sbjct: 154 PRPKTKMIGTPRYCSRASHRCEELGRRDDYESWFFMFIDLV 194
>PKNA_ANASP (P54734) Serine/threonine-protein kinase pknA (EC 2.7.11.1)| Length = 564 Score = 45.1 bits (105), Expect = 1e-04 Identities = 44/162 (27%), Positives = 65/162 (40%), Gaps = 3/162 (1%) Frame = +2 Query: 92 EWKVYDILGGIHG-VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAI 268 E + + LG G +P ++ + F +V + + A +S V I I Sbjct: 62 EAAILEDLGSYSGQIPTLYAYFQSNTQFYVVQEWVEGDTLTAKLKQQGVLSESAVRDILI 121 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 + +LE VHSK +H D+KP+N +L + K L+D G S G + Sbjct: 122 NLLPVLEYVHSKRIIHRDIKPDNIIL----RHRDGKPVLIDFGAV----RESMGTVINSQ 173 Query: 449 QRP--DIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 P I GT Y GR DL SL T ++LL Sbjct: 174 GNPTSSIVIGTPGYMPSEQAAGR-PVYSSDLYSLGLTAIYLL 214
>BUB1_YEAST (P41695) Checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) Length = 1021 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 15/88 (17%) Frame = +2 Query: 179 VMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL--LGP 352 V+D++ A N M + I +E + +LEK+H G +HGD+KP+N + L Sbjct: 787 VLDLINLQREKAIDGNG-IMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEK 845 Query: 353 PGTP-------------EEKKLFLVDLG 397 PG P E K ++L+D G Sbjct: 846 PGEPLGAHYMRNGEDGWENKGIYLIDFG 873
>CDC7_HUMAN (O00311) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (HsCdc7) (huCdc7) Length = 574 Score = 44.7 bits (104), Expect = 2e-04 Identities = 33/104 (31%), Positives = 47/104 (45%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E + + GG V V Y R+ D+ ++ M L + N+ +S + V + Sbjct: 104 ELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLN 160 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 L+++H G VH DVKP NFL KK LVD GLA Sbjct: 161 LFKALKRIHQFGIVHRDVKPSNFLY----NRRLKKYALVDFGLA 200
>CEK1_SCHPO (P38938) Serine/threonine-protein kinase cek1 (EC 2.7.11.1)| Length = 1338 Score = 44.3 bits (103), Expect = 2e-04 Identities = 24/91 (26%), Positives = 42/91 (46%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V +++Y + DY +VM+ L + + ++ + E + L +H +G Sbjct: 650 VAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLDLDWIRTYIAETVLCLGDLHDRGI 709 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 +H D+KPEN L+ G L L D GL+ Sbjct: 710 IHRDIKPENLLISQNG-----HLKLTDFGLS 735
>PKNJ_MYCTU (P65732) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 43.9 bits (102), Expect = 3e-04 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 6/160 (3%) Frame = +2 Query: 107 DILGGIH--GVPRVHYKGR-QGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAI 277 D+ G+ + VH +G+ +G +I + + G + DA + TM+ + E Sbjct: 64 DVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDAL--RAATMTTARAVYVIGEVA 121 Query: 278 SILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKE---RSTGHHVEYD 448 L+ H +G +H D+KP NFLL +E+ L L D G+A + STG + Sbjct: 122 KALDYAHQQGVIHRDIKPANFLLSRAAGGDERVL-LSDFGIARALGDTGLTSTGSVL--- 177 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 T+ YA+ G+ R DL SL L LL Sbjct: 178 -------ATLAYAAPEVLAGQGFDGRADLYSLGCALFRLL 210
>PKNJ_MYCBO (P65733) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 43.9 bits (102), Expect = 3e-04 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 6/160 (3%) Frame = +2 Query: 107 DILGGIH--GVPRVHYKGR-QGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAI 277 D+ G+ + VH +G+ +G +I + + G + DA + TM+ + E Sbjct: 64 DVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDAL--RAATMTTARAVYVIGEVA 121 Query: 278 SILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKE---RSTGHHVEYD 448 L+ H +G +H D+KP NFLL +E+ L L D G+A + STG + Sbjct: 122 KALDYAHQQGVIHRDIKPANFLLSRAAGGDERVL-LSDFGIARALGDTGLTSTGSVL--- 177 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 T+ YA+ G+ R DL SL L LL Sbjct: 178 -------ATLAYAAPEVLAGQGFDGRADLYSLGCALFRLL 210
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/66 (37%), Positives = 33/66 (50%) Frame = +2 Query: 236 MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK 415 +S E + + +S + VHS+GY H D+KPEN L E KL L+D GL K K Sbjct: 104 LSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLF-----DENHKLKLIDFGLCAKPK 158 Query: 416 ERSTGH 433 H Sbjct: 159 GNKDYH 164
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 43.5 bits (101), Expect = 4e-04 Identities = 35/135 (25%), Positives = 50/135 (37%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKP 331 G Q D +VM+ + + E+ I I+ LE H G +H DVKP Sbjct: 77 GTQDDINYIVMEYVEGKTLKDIIKEKGALPYEVAISIGIKVAKALECAHKSGIIHRDVKP 136 Query: 332 ENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGR 511 +N L+ EE + + D G+A + H + G+ Y S G Sbjct: 137 QNILV-----TEEGVVKVTDFGIAKSMDSSTIAH-------TNSVMGSAHYFSPEQAKGT 184 Query: 512 IGSRRDDLESLAYTL 556 R DL SL L Sbjct: 185 YTDYRTDLYSLGIVL 199
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 43.1 bits (100), Expect = 5e-04 Identities = 25/66 (37%), Positives = 33/66 (50%) Frame = +2 Query: 236 MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK 415 +S E + + +S + VHS+GY H D+KPEN L E KL L+D GL K K Sbjct: 104 LSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLF-----DEYHKLKLIDFGLCAKPK 158 Query: 416 ERSTGH 433 H Sbjct: 159 GNKDYH 164
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/92 (31%), Positives = 41/92 (44%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 E +S LE +H KG +H D+KPEN LL E+ + + D G A S Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILLN-----EDMHIQITDFGTAKVLSPESK------Q 236 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESL 544 R + F GT +Y S + + DL +L Sbjct: 237 ARANSFVGTAQYVSPELLTEKSACKSSDLWAL 268
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 1/85 (1%) Frame = +2 Query: 155 RQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISI-LEKVHSKGYVHGDVKP 331 ++G ++++ + G L++ NN E VA A++ + I LE +HS G VH D+K Sbjct: 176 QEGFVYLVLEYLKGGELFEYLNNNGPY--TEQVAKKAMKRVLIALEALHSNGVVHRDLKM 233 Query: 332 ENFLLGPPGTPEEKKLFLVDLGLAT 406 EN +L P P K ++D GLA+ Sbjct: 234 ENLMLENPNDPSSLK--IIDFGLAS 256
>DMPK_HUMAN (Q09013) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 639 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 1/100 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 + ++H+ + +Y +VM+ +G L + EM E + ++ VH G Sbjct: 141 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG 200 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 YVH D+KP+N LL G + L D G K + T Sbjct: 201 YVHRDIKPDNILLDRCG-----HIRLADFGSCLKLRADGT 235
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/92 (31%), Positives = 41/92 (44%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 E +S LE +H KG +H D+KPEN LL E+ + + D G A S Sbjct: 191 EIVSALEYLHGKGIIHRDLKPENILLN-----EDMHIQITDFGTAKVLSPESK------Q 239 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESL 544 R + F GT +Y S + + DL +L Sbjct: 240 ARANSFVGTAQYVSPELLTEKSACKSSDLWAL 271
>PKNF_MYCTU (P72003) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 42.4 bits (98), Expect = 0.001 Identities = 30/95 (31%), Positives = 47/95 (49%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI 463 L+ H + +H DVKP N L+ P +P ++++ L D G+A W + +G ++ Sbjct: 125 LDYAHERRLLHRDVKPANILIANPDSP-DRRIMLADFGIA-GWVDDPSGL-----TATNM 177 Query: 464 FRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 GTV YA+ +G R D +LA T LL Sbjct: 178 TVGTVSYAAPEQLMGNELDGRADQYALAATAFHLL 212
>PKNF_MYCBO (Q7TZN1) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 42.4 bits (98), Expect = 0.001 Identities = 30/95 (31%), Positives = 47/95 (49%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI 463 L+ H + +H DVKP N L+ P +P ++++ L D G+A W + +G ++ Sbjct: 125 LDYAHERRLLHRDVKPANILIANPDSP-DRRIMLADFGIA-GWVDDPSGL-----TATNM 177 Query: 464 FRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 GTV YA+ +G R D +LA T LL Sbjct: 178 TVGTVSYAAPEQLMGNELDGRADQYALAATAFHLL 212
>SPKC_SYNY3 (P74745) Serine/threonine-protein kinase C (EC 2.7.11.1)| Length = 535 Score = 42.4 bits (98), Expect = 0.001 Identities = 39/149 (26%), Positives = 68/149 (45%), Gaps = 3/149 (2%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 +P+++ +G+ F +V + + G +L A + S V + + + +LE +H + Sbjct: 79 IPQLYAYFSEGEDFYLVQEWIPGLTLTQAHAQKGNFSSTA-VEELLLGILPVLEFIHQRR 137 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRP--DIFRGTVR 481 +H D+KP+N +L + K L+D G+ + + G V D R + GT Sbjct: 138 IIHRDIKPDNIIL----READGKPILIDFGII----KETMGTLVNPDGRSAYSVALGTPG 189 Query: 482 YASVHAHLGRIGSRRDDLESLAYTLVFLL 568 Y + GR DL SL T +FLL Sbjct: 190 YMASEQAAGR-PVFSSDLYSLGLTAIFLL 217
>DMPK_MOUSE (P54265) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 631 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 1/80 (1%) Frame = +2 Query: 110 ILGGIHGVPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISIL 286 + G + ++H+ + +Y +VM+ +G L + EM E + + Sbjct: 124 VKGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 183 Query: 287 EKVHSKGYVHGDVKPENFLL 346 + VH GYVH D+KP+N LL Sbjct: 184 DSVHRLGYVHRDIKPDNILL 203
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV--- 439 E +S + +H KG +H D+KPEN L+ G + L D GLA +++E + + + Sbjct: 240 EIVSAVSHLHEKGIMHRDLKPENILMDTDG-----HVMLTDFGLAKEFEENTRSNSMCGT 294 Query: 440 -EYDQRPDIFRG 472 EY P+I RG Sbjct: 295 TEY-MAPEIVRG 305
>MK12_RAT (Q63538) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 42.0 bits (97), Expect = 0.001 Identities = 27/106 (25%), Positives = 52/106 (49%), Gaps = 1/106 (0%) Frame = +2 Query: 170 FIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLG 349 F +VM +G L T+S + + + + + L+ +H+ G +H D+KP N + Sbjct: 105 FYLVMPFMGTDLGKLM--KHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVN 162 Query: 350 PPGTPEEKKLFLVDLGLATKWKERSTGHHV-EYDQRPDIFRGTVRY 484 E+ +L ++D GLA + TG+ V + + P++ +RY Sbjct: 163 -----EDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRY 203
>MK12_MOUSE (O08911) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 42.0 bits (97), Expect = 0.001 Identities = 27/106 (25%), Positives = 52/106 (49%), Gaps = 1/106 (0%) Frame = +2 Query: 170 FIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLG 349 F +VM +G L T+S + + + + + L+ +H+ G +H D+KP N + Sbjct: 105 FYLVMPFMGTDLGKLM--KHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVN 162 Query: 350 PPGTPEEKKLFLVDLGLATKWKERSTGHHV-EYDQRPDIFRGTVRY 484 E+ +L ++D GLA + TG+ V + + P++ +RY Sbjct: 163 -----EDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRY 203
>PMYT1_MOUSE (Q9ESG9) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 490 Score = 42.0 bits (97), Expect = 0.001 Identities = 35/127 (27%), Positives = 54/127 (42%), Gaps = 3/127 (2%) Frame = +2 Query: 137 RVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVH 316 R+ +G + ++ G SL C ++ V + + L+ +HS+G VH Sbjct: 163 RLERAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDILLALDHLHSQGLVH 222 Query: 317 GDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR---PDIFRGTVRYA 487 DVKP N LGP G + L D GL + G E D R P++ +G+ A Sbjct: 223 LDVKPANIFLGPRG-----RCKLGDFGLLVELGSTGAGEAQEGDPRYMAPELLQGSYGTA 277 Query: 488 SVHAHLG 508 + LG Sbjct: 278 ADVFSLG 284
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV--- 439 E +S + +H KG +H D+KPEN L+ G + L D GLA +++E + + + Sbjct: 246 EIVSAVSHLHEKGIMHRDLKPENILMDVDG-----HVMLTDFGLAKEFEENTRSNSMCGT 300 Query: 440 -EYDQRPDIFRG 472 EY P+I RG Sbjct: 301 TEY-MAPEIVRG 311
>MRCKG_MOUSE (Q80UW5) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/84 (29%), Positives = 36/84 (42%), Gaps = 1/84 (1%) Frame = +2 Query: 110 ILGGIHGVPRVHYKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISIL 286 + G V +HY + +Y +VMD G L + E+ E + + Sbjct: 124 VKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183 Query: 287 EKVHSKGYVHGDVKPENFLLGPPG 358 +H GYVH DVKP+N LL G Sbjct: 184 HSLHQLGYVHRDVKPDNILLDMNG 207
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/92 (31%), Positives = 41/92 (44%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 E +S LE +H KG +H D+KPEN LL E+ + + D G A S Sbjct: 191 EIVSALEYLHGKGIIHRDLKPENILLN-----EDMHIQITDFGTAKVLSPDSK------Q 239 Query: 449 QRPDIFRGTVRYASVHAHLGRIGSRRDDLESL 544 R + F GT +Y S + + DL +L Sbjct: 240 ARANSFVGTAQYVSPELLTEKSACKSSDLWAL 271
>STK16_RAT (P57760) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) Length = 304 Score = 41.6 bits (96), Expect = 0.002 Identities = 20/38 (52%), Positives = 24/38 (63%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLG 397 LE +H+KGY H D+KP N LLG G P L+DLG Sbjct: 135 LEAIHAKGYAHRDLKPTNILLGDEGQP-----VLMDLG 167
>STK16_MOUSE (O88697) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct) Length = 304 Score = 41.6 bits (96), Expect = 0.002 Identities = 20/38 (52%), Positives = 24/38 (63%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLG 397 LE +H+KGY H D+KP N LLG G P L+DLG Sbjct: 135 LEAIHAKGYAHRDLKPTNILLGDEGQP-----VLMDLG 167
>STK16_HUMAN (O75716) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK) Length = 304 Score = 41.6 bits (96), Expect = 0.002 Identities = 20/38 (52%), Positives = 24/38 (63%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLG 397 LE +H+KGY H D+KP N LLG G P L+DLG Sbjct: 135 LEAIHAKGYAHRDLKPTNILLGDEGQP-----VLMDLG 167
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 41.6 bits (96), Expect = 0.002 Identities = 35/128 (27%), Positives = 57/128 (44%), Gaps = 2/128 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 DIL +H V R+HY + +++D L + + E V E Sbjct: 114 DILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 173 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD 460 L+ +HS G ++ D+KPEN LL EE + L D GL+ + ++++++ Sbjct: 174 GLDHLHSLGIIYRDLKPENILL-----DEEGHIKLTDFGLSKE--------AIDHEKKAY 220 Query: 461 IFRGTVRY 484 F GTV Y Sbjct: 221 SFCGTVEY 228 Score = 30.8 bits (68), Expect = 2.8 Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 2/47 (4%) Frame = +2 Query: 245 EMVACIAIEAI-SILEKVHSKGYVHGDVKPENFL-LGPPGTPEEKKL 379 E AC + + +E +HS+G VH D+KP N L + G PE ++ Sbjct: 507 EREACSVLFTVCKTVEYLHSQGVVHRDLKPSNILYVDESGDPESIRI 553
>CDC7_MOUSE (Q9Z0H0) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (muCdc7) Length = 564 Score = 41.6 bits (96), Expect = 0.002 Identities = 32/104 (30%), Positives = 46/104 (44%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIE 271 E + + GG V + Y R+ D+ ++ M L + N+ +S + V Sbjct: 98 ELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMYN 154 Query: 272 AISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 L+++H G VH DVKP NFL KK LVD GLA Sbjct: 155 LFVALKRIHQFGIVHRDVKPSNFLY----NRRLKKYALVDFGLA 194
>ROCK2_HUMAN (O75116) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) Length = 1388 Score = 41.6 bits (96), Expect = 0.002 Identities = 34/116 (29%), Positives = 50/116 (43%), Gaps = 3/116 (2%) Frame = +2 Query: 95 WKVYDILGGIHG--VPRVHYKGRQGDYFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIA 265 W+ DI+ + V ++ Y + Y MVM+ M G L + N + + + Sbjct: 138 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN--YDVPEKWAKFYT 195 Query: 266 IEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGH 433 E + L+ +HS G +H DVKP+N LL G L L D G K E H Sbjct: 196 AEVVLALDAIHSMGLIHRDVKPDNMLLDKHG-----HLKLADFGTCMKMDETGMVH 246
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 41.6 bits (96), Expect = 0.002 Identities = 35/128 (27%), Positives = 57/128 (44%), Gaps = 2/128 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 DIL +H V R+HY + +++D L + + E V E Sbjct: 114 DILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 173 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD 460 L+ +HS G ++ D+KPEN LL EE + L D GL+ + ++++++ Sbjct: 174 GLDHLHSLGIIYRDLKPENILL-----DEEGHIKLTDFGLSKE--------AIDHEKKAY 220 Query: 461 IFRGTVRY 484 F GTV Y Sbjct: 221 SFCGTVEY 228 Score = 31.6 bits (70), Expect = 1.7 Identities = 17/41 (41%), Positives = 24/41 (58%), Gaps = 1/41 (2%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFL-LGPPGTPEEKKLFLVDLGLA 403 +E +HS+G VH D+KP N L + G PE + + D G A Sbjct: 521 VENLHSQGVVHRDLKPSNILYVDESGDPE--SIRICDFGFA 559
>MRCKG_HUMAN (Q6DT37) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 41.6 bits (96), Expect = 0.002 Identities = 25/84 (29%), Positives = 36/84 (42%), Gaps = 1/84 (1%) Frame = +2 Query: 110 ILGGIHGVPRVHYKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISIL 286 + G V +HY + +Y +VMD G L + E+ E + + Sbjct: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183 Query: 287 EKVHSKGYVHGDVKPENFLLGPPG 358 +H GYVH DVKP+N LL G Sbjct: 184 HSLHQLGYVHRDVKPDNVLLDVNG 207
>BUB1_MOUSE (O08901) Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) (MBUB1) (BUB1A) Length = 1058 Score = 41.6 bits (96), Expect = 0.002 Identities = 23/65 (35%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Frame = +2 Query: 236 MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKK-----LFLVDLGL 400 M +V AI + ++E+VHS +HGD+KP+NF+LG + + L L+DLG Sbjct: 863 MPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLALIDLGQ 922 Query: 401 ATKWK 415 + K Sbjct: 923 SIDMK 927
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 41.2 bits (95), Expect = 0.002 Identities = 27/117 (23%), Positives = 49/117 (41%), Gaps = 16/117 (13%) Frame = +2 Query: 164 DYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 + ++++ M G SL + NN ++ + +A I E + L+ +H K +H D+K +N L Sbjct: 751 ELWVIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKHIIHRDIKSDNVL 810 Query: 344 LGPPGTPEEKKLFLVDLGLATK----------------WKERSTGHHVEYDQRPDIF 466 L G + + D G K W EYD++ D++ Sbjct: 811 LDAYGNVK-----ITDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVW 862
>PKH3_ASHGO (Q753D9) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| Length = 726 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/121 (24%), Positives = 48/121 (39%) Frame = +2 Query: 128 GVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 G+ +++Y + VMD+ S + + +E +HS G Sbjct: 72 GIIKLYYTFHDQENLYFVMDLAPGGELLQLLRRQRVFSEAWARHYMCQLVDTVEYIHSMG 131 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYA 487 +H D+KPEN LL +E +L + D G A + G + D+ F GT Y Sbjct: 132 VIHRDLKPENVLL-----DKEGRLMIADFGAAYTVGQSDAGS--DGDKPATSFVGTAEYV 184 Query: 488 S 490 S Sbjct: 185 S 185
>ROCK1_RAT (Q63644) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) Length = 1369 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 3/108 (2%) Frame = +2 Query: 95 WKVYDILGGIHG--VPRVHYKGRQGDYFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIA 265 W+ DI+ + V ++ Y + Y MVM+ M G L + N + + + Sbjct: 122 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN--YDVPEKWARFYT 179 Query: 266 IEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 E + L+ +HS G++H DVKP+N LL G L L D G K Sbjct: 180 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/107 (29%), Positives = 51/107 (47%), Gaps = 5/107 (4%) Frame = +2 Query: 158 QGDYFIMVMDMLGFSLWDACCNNSHTMSVE-MVACIAIEAISILEKVHSKGYVHGDVKPE 334 +GD ++++ M G SL D +H + E + + E +S LE +HSKG +H D+K + Sbjct: 687 KGDLWVIMEYMEGGSLTDVV---THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSD 743 Query: 335 NFLLGPPGTPEEKKLFLVDLGLATKWKE----RSTGHHVEYDQRPDI 463 N LL G + L D G + E R+T Y P++ Sbjct: 744 NILLSMEG-----DIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEV 785
>ROCK1_RABIT (O77819) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (cAMP-dependent protein kinase ROCK-I) (CePKA) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEB Length = 1354 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 3/108 (2%) Frame = +2 Query: 95 WKVYDILGGIHG--VPRVHYKGRQGDYFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIA 265 W+ DI+ + V ++ Y + Y MVM+ M G L + N + + + Sbjct: 122 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN--YDVPEKWARFYT 179 Query: 266 IEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 E + L+ +HS G++H DVKP+N LL G L L D G K Sbjct: 180 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>ROCK1_MOUSE (P70335) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 3/108 (2%) Frame = +2 Query: 95 WKVYDILGGIHG--VPRVHYKGRQGDYFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIA 265 W+ DI+ + V ++ Y + Y MVM+ M G L + N + + + Sbjct: 122 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN--YDVPEKWARFYT 179 Query: 266 IEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 E + L+ +HS G++H DVKP+N LL G L L D G K Sbjct: 180 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>ROCK1_HUMAN (Q13464) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen) Length = 1354 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 3/108 (2%) Frame = +2 Query: 95 WKVYDILGGIHG--VPRVHYKGRQGDYFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIA 265 W+ DI+ + V ++ Y + Y MVM+ M G L + N + + + Sbjct: 122 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN--YDVPEKWARFYT 179 Query: 266 IEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 E + L+ +HS G++H DVKP+N LL G L L D G K Sbjct: 180 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 41.2 bits (95), Expect = 0.002 Identities = 28/106 (26%), Positives = 50/106 (47%), Gaps = 1/106 (0%) Frame = +2 Query: 170 FIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLG 349 F +VM +G L +S E V + + + L+ +H+ G +H D+KP N + Sbjct: 103 FYLVMPFMGTDLGKLM--KMERLSEERVQYLVYQMLKGLKYIHAAGIIHRDLKPGNLAIN 160 Query: 350 PPGTPEEKKLFLVDLGLATKWKERSTGHHV-EYDQRPDIFRGTVRY 484 EE +L ++D GLA + TG+ V + + P++ + Y Sbjct: 161 -----EECELKILDFGLARQTDSEMTGYVVTRWYRAPEVILSWMHY 201
>CTRO_HUMAN (O14578) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2027 Score = 41.2 bits (95), Expect = 0.002 Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 1/94 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 +P++ Y + ++ +VM+ G L + ++ E I + VH G Sbjct: 157 IPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMG 216 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 YVH D+KPEN L+ G + LVD G A K Sbjct: 217 YVHRDIKPENILVDRTG-----HIKLVDFGSAAK 245
>CTRO_MOUSE (P49025) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2055 Score = 41.2 bits (95), Expect = 0.002 Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 1/94 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 +P++ Y + + +VM+ G + M+ E I + VH G Sbjct: 157 IPQLQYAFQDKNNLYLVMEYQPGGDFLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMG 216 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 YVH D+KPEN L+ G ++ LVD G A K Sbjct: 217 YVHRDIKPENILIDRTG-----EIKLVDFGSAAK 245
>CBK1_YEAST (P53894) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1) (Cell| wall biosynthesis kinase) Length = 756 Score = 40.8 bits (94), Expect = 0.003 Identities = 32/155 (20%), Positives = 69/155 (44%), Gaps = 5/155 (3%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 D+L G V ++Y + Y ++M+ L + ++ E I Sbjct: 402 DVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECIL 461 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKW-KERSTGHHVEYDQRP 457 +E +H G++H D+KP+N L+ G + L D GL+T + K + ++ + Q+ Sbjct: 462 AIETIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGLSTGFHKTHDSNYYKKLLQQD 516 Query: 458 DIFRGTVRYASVHAHLGRIGSRRDDL--ESLAYTL 556 + G + + +A+ ++R + +S++ T+ Sbjct: 517 EATNGISKPGTYNANTTDTANKRQTMVVDSISLTM 551
>KBN8_YEAST (P38070) Probable serine/threonine-protein kinase YBR028C (EC| 2.7.11.1) Length = 525 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/114 (30%), Positives = 50/114 (43%), Gaps = 2/114 (1%) Frame = +2 Query: 233 TMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKW 412 T+ V+ A E L +H+KG V+ D+KPEN LL G L L D GL+ K Sbjct: 248 TLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRG-----HLVLTDFGLSKKS 302 Query: 413 KERSTGHHVEYDQRPDIFR--GTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 S + + ++ GT Y + LG+ S+ D SL L +L Sbjct: 303 ANDSAVDEEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDML 356
>ORB6_SCHPO (O13310) Serine/threonine-protein kinase orb6 (EC 2.7.11.1)| Length = 469 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/92 (27%), Positives = 41/92 (44%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V ++Y + Y ++M+ L N T S ++ E + + VH GY Sbjct: 153 VVSLYYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVLAIADVHRMGY 212 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLAT 406 +H D+KP+N L+ G + L D GL+T Sbjct: 213 IHRDIKPDNILIDRDG-----HIKLSDFGLST 239
>RAN1_SCHPO (P08092) Negative regulator of sexual conjugation and meiosis (EC| 2.7.11.1) Length = 470 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/61 (36%), Positives = 34/61 (55%) Frame = +2 Query: 224 NSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 NSH ++ + ++ IS +E HS G H D+KPEN ++G + ++L D GLA Sbjct: 116 NSH-----LIKTVFLQLISAVEHCHSVGIYHRDLKPENIMVG----NDVNTVYLADFGLA 166 Query: 404 T 406 T Sbjct: 167 T 167
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 40.8 bits (94), Expect = 0.003 Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 1/81 (1%) Frame = +2 Query: 176 MVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +VM++ G L+D H S A + + ++E HS G +H D+KPENFL Sbjct: 110 LVMELCEGGELFDRIVQKGH-YSERQAARLIKTIVEVVEACHSLGVMHRDLKPENFLFDT 168 Query: 353 PGTPEEKKLFLVDLGLATKWK 415 E+ KL D GL+ +K Sbjct: 169 --IDEDAKLKATDFGLSVFYK 187
>PMYT1_HUMAN (Q99640) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 499 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/127 (27%), Positives = 53/127 (41%), Gaps = 3/127 (2%) Frame = +2 Query: 137 RVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVH 316 R+ +G + ++ G SL C ++ V + + L +HS+G VH Sbjct: 172 RLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVH 231 Query: 317 GDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR---PDIFRGTVRYA 487 DVKP N LGP G + L D GL + G E D R P++ +G+ A Sbjct: 232 LDVKPANIFLGPRG-----RCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTA 286 Query: 488 SVHAHLG 508 + LG Sbjct: 287 ADVFSLG 293
>CBK1_PNECA (Q6TGC6) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 507 Score = 40.8 bits (94), Expect = 0.003 Identities = 28/106 (26%), Positives = 44/106 (41%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V ++Y + Y ++M+ L T S ++ E I +E VH G+ Sbjct: 186 VVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIKYDTFSEDVTRFYIAECILAIEAVHKLGF 245 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 +H D+KP+N L+ G + L D GL S G H +D Sbjct: 246 IHRDIKPDNILIDKTG-----HIKLSDFGL-------SMGFHKTHD 279
>UHMK1_RAT (Q63285) Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase| interacting with stathmin) (U2AF homology motif kinase 1) (PAM COOH-terminal interactor protein 2) (P-CIP2) Length = 419 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 1/97 (1%) Frame = +2 Query: 122 IHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVH 298 ++GV +H+ ++ +++L S+ + +SH S+ M+ A + + L +H Sbjct: 92 LYGVFTIHFSPNVPSRCLL-LELLDVSVSELLVYSSHQGCSMWMIQHCARDVLEALAFLH 150 Query: 299 SKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 +GYVH D+KP N L + E + L+D GL+ K Sbjct: 151 HEGYVHADLKPRNIL----WSAENECFKLIDFGLSFK 183
>UHMK1_MOUSE (P97343) Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase| interacting with stathmin) (U2AF homology motif kinase 1) Length = 419 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 1/97 (1%) Frame = +2 Query: 122 IHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVH 298 ++GV +H+ ++ +++L S+ + +SH S+ M+ A + + L +H Sbjct: 92 LYGVFTIHFSPNVPSRCLL-LELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLH 150 Query: 299 SKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 +GYVH D+KP N L + E + L+D GL+ K Sbjct: 151 HEGYVHADLKPRNIL----WSAENECFKLIDFGLSFK 183
>UHMK1_HUMAN (Q8TAS1) Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase| interacting with stathmin) (U2AF homology motif kinase 1) Length = 419 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 1/97 (1%) Frame = +2 Query: 122 IHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVH 298 ++GV +H+ ++ +++L S+ + +SH S+ M+ A + + L +H Sbjct: 92 LYGVFTIHFSPNVPSRCLL-LELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLH 150 Query: 299 SKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 +GYVH D+KP N L + E + L+D GL+ K Sbjct: 151 HEGYVHADLKPRNIL----WSAENECFKLIDFGLSFK 183
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 40.4 bits (93), Expect = 0.004 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 4/108 (3%) Frame = +2 Query: 164 DYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENF 340 +Y+ +V D+ G L+D + V+ A I + +S + +H VH D+KPEN Sbjct: 140 NYYYLVSDVYSGGELFDEIISRKRFYEVD-AARIIKQVLSGITYMHKNNVVHRDLKPENI 198 Query: 341 LLGPPGTPEEKKLFLVDLGLATKW---KERSTGHHVEYDQRPDIFRGT 475 LL E+ + ++D GL+T + K+ Y PD+ GT Sbjct: 199 LL-ETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT 245
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 40.4 bits (93), Expect = 0.004 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 4/108 (3%) Frame = +2 Query: 164 DYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENF 340 +Y+ +V D+ G L+D + V+ A I + +S + +H VH D+KPEN Sbjct: 140 NYYYLVSDVYSGGELFDEIISRKRFYEVD-AARIIKQVLSGITYMHKNNVVHRDLKPENI 198 Query: 341 LLGPPGTPEEKKLFLVDLGLATKW---KERSTGHHVEYDQRPDIFRGT 475 LL E+ + ++D GL+T + K+ Y PD+ GT Sbjct: 199 LL-ETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT 245
>VHS1_YEAST (Q03785) Serine/threonine-protein kinase VHS1 (EC 2.7.11.1) (Viable| in a HAL3 SIT4 background protein 1) Length = 461 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 1/78 (1%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHTMSVEM-VACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +VMD L+ + +N H ++ + V + ++ S L H G H D+KPEN LL Sbjct: 136 IVMDYYPTDLFTSIVDNRHFVTNGLLVKKVFLQICSALNYCHEHGIYHCDIKPENLLL-- 193 Query: 353 PGTPEEKKLFLVDLGLAT 406 E +FL D GL+T Sbjct: 194 ---DTEDNVFLCDFGLST 208
>KAB7_SCHPO (Q09815) Probable serine/threonine-protein kinase C16C9.07 (EC| 2.7.12.1) Length = 836 Score = 40.4 bits (93), Expect = 0.004 Identities = 22/86 (25%), Positives = 47/86 (54%), Gaps = 1/86 (1%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 + +V ++LG +L+D N++ + + +V A++ + L + + +H D+KPEN L Sbjct: 592 HLCIVTELLGSNLFDVIRENNYKGLPLIVVKSFALQGLQALRLLQGQNIIHCDLKPENLL 651 Query: 344 LGPPGTPEEKKLFLVDLGLATKWKER 421 L P + ++ L+D G + + E+ Sbjct: 652 L---SHPLKARIKLIDFGSSCFYNEK 674
>HIPK3_HUMAN (Q9H422) Homeodomain-interacting protein kinase 3 (EC 2.7.11.1)| (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK) Length = 1215 Score = 40.4 bits (93), Expect = 0.004 Identities = 28/102 (27%), Positives = 54/102 (52%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++++ I + + L+K+ S G +H D+KPEN +L Sbjct: 273 LVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVD 332 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + ++ ++D G A+ + ST Y + P+I G Sbjct: 333 P-VRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
>LATS2_HUMAN (Q9NRM7) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase) Length = 1088 Score = 40.0 bits (92), Expect = 0.005 Identities = 29/112 (25%), Positives = 44/112 (39%), Gaps = 6/112 (5%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V +++Y + D VMD + + + E +E VH G+ Sbjct: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLAT--KWKERS----TGHHVEYD 448 +H D+KP+N L+ G + L D GL T +W S G HV D Sbjct: 788 IHRDIKPDNILIDLDG-----HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQD 834
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 3/79 (3%) Frame = +2 Query: 263 AIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTG-HHV 439 A + I ++ +HS G +H D+KPEN LL E K+ L D G A + Sbjct: 284 AAQIIDAIDYLHSNGIIHRDIKPENILL-----DGEMKIKLTDFGTAKLLNPTNNSVSKP 338 Query: 440 EYD--QRPDIFRGTVRYAS 490 EYD R F GT Y S Sbjct: 339 EYDLSTRSKSFVGTAEYVS 357
>M3K8_MOUSE (Q07174) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene) Length = 467 Score = 40.0 bits (92), Expect = 0.005 Identities = 31/94 (32%), Positives = 41/94 (43%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI 463 L+ +HSK +H D+KP N + K LVD GL+ K E P Sbjct: 241 LDFLHSKKVIHHDIKPSNIVF------MSTKAVLVDFGLSVKMTEDV--------YLPKD 286 Query: 464 FRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFL 565 RGT Y S L R S + D+ SL TL+ + Sbjct: 287 LRGTEIYMSPEVILCRGHSTKADIYSLGATLIHM 320
>YAK1_YEAST (P14680) Dual specificity protein kinase YAK1 (EC 2.7.12.1)| Length = 807 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 7/109 (6%) Frame = +2 Query: 92 EWKVYDILGGIHGVPRVHYKGRQGDYFI------MVMDMLGFSLWDACCNNS-HTMSVEM 250 E K+ ++L H+ R D F+ +V ++L +L++ N H +S+++ Sbjct: 413 EAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQL 472 Query: 251 VACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLG 397 + + + L + +H D+KPEN LL P PE K ++D G Sbjct: 473 IRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELK---IIDFG 518
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 40.0 bits (92), Expect = 0.005 Identities = 34/140 (24%), Positives = 59/140 (42%), Gaps = 1/140 (0%) Frame = +2 Query: 152 GRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVK 328 G + D + +VM+ + G +L + N E + I + +S + H VH D+K Sbjct: 78 GEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALN-IMEQIVSAIAHAHQNQIVHRDIK 136 Query: 329 PENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLG 508 P N L+ G + + D G+AT + H + G+V Y S G Sbjct: 137 PHNILIDHMG-----NIKVTDFGIATALSSTTITH-------TNSVLGSVHYLSPEQARG 184 Query: 509 RIGSRRDDLESLAYTLVFLL 568 + +++ D+ +L L LL Sbjct: 185 GLATKKSDIYALGIVLFELL 204
>HIPK3_MOUSE (Q9ERH7) Homeodomain-interacting protein kinase 3 (EC 2.7.11.1)| (Fas-interacting serine/threonine-protein kinase) (FIST) (Nuclear body-associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK) Length = 1192 Score = 40.0 bits (92), Expect = 0.005 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++++ + + + L+K+ S G +H D+KPEN +L Sbjct: 273 LVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVD 332 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + ++ ++D G A+ + ST Y + P+I G Sbjct: 333 P-VRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 40.0 bits (92), Expect = 0.005 Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 4/61 (6%) Frame = +2 Query: 233 TMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPG----TPEEKKLFLVDLGL 400 T+S + V + + +HSKG +H D+KP+N LL PG P ++ + D G Sbjct: 109 TLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGF 168 Query: 401 A 403 A Sbjct: 169 A 169
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 40.0 bits (92), Expect = 0.005 Identities = 25/83 (30%), Positives = 40/83 (48%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 ++I+ G L+D + V+ V I ++ + +E +HSK VH D+KPEN L Sbjct: 121 FYIVTQLATGGELFDRILSRGKFTEVDAVEII-VQILGAVEYMHSKNVVHRDLKPENVLY 179 Query: 347 GPPGTPEEKKLFLVDLGLATKWK 415 E L + D G+A + K Sbjct: 180 --VDKSENSPLVIADFGIAKQLK 200
>MRCKB_RAT (Q7TT49) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 40.0 bits (92), Expect = 0.005 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 1/105 (0%) Frame = +2 Query: 116 GGIHGVPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISILEK 292 G + +HY + +Y +VMD +G L + +M E + ++ Sbjct: 131 GDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDS 190 Query: 293 VHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 +H YVH D+KP+N LL G + L D G K + T Sbjct: 191 IHQLHYVHRDIKPDNVLLDVNG-----HIRLADFGSCLKMNDDGT 230
>MRCKB_MOUSE (Q7TT50) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 40.0 bits (92), Expect = 0.005 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 1/105 (0%) Frame = +2 Query: 116 GGIHGVPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISILEK 292 G + +HY + +Y +VMD +G L + +M E + ++ Sbjct: 131 GDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDS 190 Query: 293 VHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 +H YVH D+KP+N LL G + L D G K + T Sbjct: 191 IHQLHYVHRDIKPDNVLLDVNG-----HIRLADFGSCLKMNDDGT 230
>MAST2_MOUSE (Q60592) Microtubule-associated serine/threonine-protein kinase 2| (EC 2.7.11.1) Length = 1734 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/96 (29%), Positives = 43/96 (44%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 + MVM+ + N + V+MV E + LE +H+ G VH D+KP+N L+ Sbjct: 525 HLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLI 584 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 G + L +GL + G H+E D R Sbjct: 585 TSMGHIKLTDFGLSKIGLMSLTTNLYEG-HIEKDAR 619
>MAST2_HUMAN (Q6P0Q8) Microtubule-associated serine/threonine-protein kinase 2| (EC 2.7.11.1) Length = 1798 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/96 (29%), Positives = 43/96 (44%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 + MVM+ + N + V+MV E + LE +H+ G VH D+KP+N L+ Sbjct: 584 HLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLI 643 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 G + L +GL + G H+E D R Sbjct: 644 TSMGHIKLTDFGLSKIGLMSLTTNLYEG-HIEKDAR 678
>KSP1_YEAST (P38691) Serine/threonine-protein kinase KSP1 (EC 2.7.11.1)| Length = 1029 Score = 40.0 bits (92), Expect = 0.005 Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 3/104 (2%) Frame = +2 Query: 164 DYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 D +I++ G L++A ++ + + I + + +E VH+KG H D+KPEN L Sbjct: 155 DSYIIMEYCSGGDLYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENIL 214 Query: 344 LGPPGTPEEKKLFLVDLGLATKWK---ERSTGHHVEYDQRPDIF 466 + + + + L D GLAT K +R+ G E P++F Sbjct: 215 I----SGIDWTIKLTDWGLATTDKTSMDRNVGS--ERYMSPELF 252
>SID2_SCHPO (Q09898) Serine/threonine-protein kinase sid2 (EC 2.7.11.1)| Length = 607 Score = 40.0 bits (92), Expect = 0.005 Identities = 21/62 (33%), Positives = 32/62 (51%) Frame = +2 Query: 221 NNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGL 400 +NS + A E ++ +H GY+H D+KPENFL+G G + L D GL Sbjct: 298 SNSGVLRDHHAKFYATEMFLAIDALHQLGYIHRDLKPENFLVGASG-----HIKLTDFGL 352 Query: 401 AT 406 ++ Sbjct: 353 SS 354
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/103 (27%), Positives = 46/103 (44%) Frame = +2 Query: 260 IAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV 439 I E +S ++ HS G +H D+KP+N L+ GT + + D G+A E S Sbjct: 116 IITEILSAMDMAHSHGIIHRDLKPQNVLVSSSGTVK-----VTDFGIAKALSETSL---- 166 Query: 440 EYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 + + G+V Y S G + + D+ ++ L LL Sbjct: 167 ---TQTNTMFGSVHYLSPEQARGSNATVQSDIYAIGIILFELL 206
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 40.0 bits (92), Expect = 0.005 Identities = 33/125 (26%), Positives = 55/125 (44%), Gaps = 13/125 (10%) Frame = +2 Query: 221 NNSHTMSVEMVACIAIEAISILEKV------HSKGYVHGDVKPENFLLGPPGTPEEKKLF 382 N H + EM ++++ ILE + H KG +H D+KPEN L+ + + Sbjct: 99 NLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILV-----DNDFHIK 153 Query: 383 LVDLGLAT--KWKERSTGHHVEYDQRPDIFR--GTVRYASVHAHLGRIGSR---RDDLES 541 + DLGLA+ W + + H E + + G Y HL + ++ + D+ S Sbjct: 154 IADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYS 213 Query: 542 LAYTL 556 A L Sbjct: 214 FAVVL 218
>HIPK3_RAT (O88850) Homeodomain-interacting protein kinase 3 (EC 2.7.11.1)| (Androgen receptor-interacting nuclear protein kinase) (ANPK) Length = 1191 Score = 40.0 bits (92), Expect = 0.005 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++++ + + + L+K+ S G +H D+KPEN +L Sbjct: 273 LVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVD 332 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + ++ ++D G A+ + ST Y + P+I G Sbjct: 333 P-VRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
>PKAB_STRCO (P54740) Serine/threonine protein kinase pkaB (EC 2.7.11.1)| Length = 417 Score = 39.7 bits (91), Expect = 0.006 Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 3/84 (3%) Frame = +2 Query: 161 GDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENF 340 G+ +VMD++ + + ++ E + + L H+ G VH DVKPEN Sbjct: 77 GNDLALVMDLVRGTDLRTRLDRERRLAPEAAVAVVADVADGLAAAHAAGVVHRDVKPENV 136 Query: 341 LL---GPPGTPEEKKLFLVDLGLA 403 LL GP G L D G+A Sbjct: 137 LLDMQGPLGPGGSHPALLTDFGVA 160
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 39.7 bits (91), Expect = 0.006 Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 5/158 (3%) Frame = +2 Query: 110 ILGGIHG--VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNS--HTMSVEMVACIAIEA 274 I+ G H + R++ + Y M+M+ LG LW + + +EA Sbjct: 427 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 486 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 + L HSKG ++ D+KPEN +L G + LVD G A K + + ++ Sbjct: 487 FAYL---HSKGIIYRDLKPENLILDHRGYAK-----LVDFGFAKK---------IGFGKK 529 Query: 455 PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 F GT Y + L + D SL + LL Sbjct: 530 TWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 567
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 39.7 bits (91), Expect = 0.006 Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 5/158 (3%) Frame = +2 Query: 110 ILGGIHG--VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNS--HTMSVEMVACIAIEA 274 I+ G H + R++ + Y M+M+ LG LW + + +EA Sbjct: 427 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 486 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 + L HSKG ++ D+KPEN +L G + LVD G A K + + ++ Sbjct: 487 FAYL---HSKGIIYRDLKPENLILDHRGYAK-----LVDFGFAKK---------IGFGKK 529 Query: 455 PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 F GT Y + L + D SL + LL Sbjct: 530 TWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 567
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 39.7 bits (91), Expect = 0.006 Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 5/158 (3%) Frame = +2 Query: 110 ILGGIHG--VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNS--HTMSVEMVACIAIEA 274 I+ G H + R++ + Y M+M+ LG LW + + +EA Sbjct: 427 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 486 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 + L HSKG ++ D+KPEN +L G + LVD G A K + + ++ Sbjct: 487 FAYL---HSKGIIYRDLKPENLILDHRGYAK-----LVDFGFAKK---------IGFGKK 529 Query: 455 PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 F GT Y + L + D SL + LL Sbjct: 530 TWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 567
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 39.7 bits (91), Expect = 0.006 Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +HS +H D+K +N Sbjct: 337 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDN 394 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 395 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 435
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 39.7 bits (91), Expect = 0.006 Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +HS +H D+K +N Sbjct: 337 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDN 394 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 395 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 435
>LATS2_MOUSE (Q7TSJ6) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) Length = 1042 Score = 39.7 bits (91), Expect = 0.006 Identities = 28/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V +++Y + D VMD + + + E +E VH G+ Sbjct: 686 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 745 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLAT--KWKERS----TGHHVEYD 448 +H D+KP+N L+ G + L D GL T +W S G+H+ D Sbjct: 746 IHRDIKPDNILIDLDG-----HIKLTDFGLCTGFRWTHNSKYYQKGNHMRQD 792
>MAST1_RAT (Q810W7) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 39.7 bits (91), Expect = 0.006 Identities = 28/96 (29%), Positives = 42/96 (43%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 + MVM+ + N + VEM E + LE +H+ G VH D+KP+N L+ Sbjct: 448 HLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLI 507 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 G + L +GL + G H+E D R Sbjct: 508 TSMGHIKLTDFGLSKMGLMSLTTNLYEG-HIEKDAR 542
>MAST1_HUMAN (Q9Y2H9) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 39.7 bits (91), Expect = 0.006 Identities = 28/96 (29%), Positives = 42/96 (43%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 + MVM+ + N + VEM E + LE +H+ G VH D+KP+N L+ Sbjct: 446 HLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLI 505 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 G + L +GL + G H+E D R Sbjct: 506 TSMGHIKLTDFGLSKMGLMSLTTNLYEG-HIEKDAR 540
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 39.7 bits (91), Expect = 0.006 Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 5/86 (5%) Frame = +2 Query: 242 VEMVACIAIEAI-SILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK- 415 VEM A ++ I S+L +H + H D+KPENFL T E + ++D GLA + Sbjct: 205 VEMYASFIMKQIFSVLNYLHIRNICHRDIKPENFLFYDKST--ESLIKIIDFGLAAYFND 262 Query: 416 ---ERSTGHHVEYDQRPDIFRGTVRY 484 E T Y P + G Y Sbjct: 263 IDYEMKTKAGTPYYVAPQVLTGCYDY 288
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 39.7 bits (91), Expect = 0.006 Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +HS +H D+K +N Sbjct: 336 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDN 393 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 394 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 434
>MAST1_MOUSE (Q9R1L5) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1566 Score = 39.7 bits (91), Expect = 0.006 Identities = 28/96 (29%), Positives = 42/96 (43%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 + MVM+ + N + VEM E + LE +H+ G VH D+KP+N L+ Sbjct: 447 HLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLI 506 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 G + L +GL + G H+E D R Sbjct: 507 TSMGHIKLTDFGLSKMGLMSLTTNLYEG-HIEKDAR 541
>SPKD_SYNY3 (P54735) Serine/threonine-protein kinase D (EC 2.7.11.1)| Length = 505 Score = 39.7 bits (91), Expect = 0.006 Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Frame = +2 Query: 131 VPRVH-YKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 +P+++ Y +++++ + G SL N +S E I ++ L+ +HSKG Sbjct: 77 IPKLYSYFSNDNEFYLVQEYIQGVSL-----NEIAPISSEQAKTILSSLLTTLKYIHSKG 131 Query: 308 YVHGDVKPENFLL 346 +H D+KPEN +L Sbjct: 132 IIHRDIKPENIIL 144
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 39.7 bits (91), Expect = 0.006 Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 2/128 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 DIL ++ + ++HY + +++D L + + E V E Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD 460 L+ +HS G ++ D+KPEN LL EE + + D GL+ + +++D+R Sbjct: 171 ALDHLHSLGIIYRDLKPENILL-----DEEGHIKITDFGLSKE--------AIDHDKRAY 217 Query: 461 IFRGTVRY 484 F GT+ Y Sbjct: 218 SFCGTIEY 225 Score = 30.8 bits (68), Expect = 2.8 Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 2/83 (2%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 G + +VM+++ G L D + S + + ++ +HS+G VH D+KP N Sbjct: 479 GKFVYLVMELMRGGELLDRILRQRY-FSEREASDVLCTITKTMDYLHSQGVVHRDLKPSN 537 Query: 338 FLL-GPPGTPEEKKLFLVDLGLA 403 L G+PE + + D G A Sbjct: 538 ILYRDESGSPE--SIRVCDFGFA 558
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 39.7 bits (91), Expect = 0.006 Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 4/108 (3%) Frame = +2 Query: 164 DYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENF 340 +Y+ +V D+ G L+D + ++ A I + +S + +H VH D+KPEN Sbjct: 140 NYYYLVSDVYTGGELFDEIISRKRFYEID-AARIIKQILSGITYMHKNNVVHRDLKPENI 198 Query: 341 LLGPPGTPEEKKLFLVDLGLATKW---KERSTGHHVEYDQRPDIFRGT 475 LL E+ + ++D GL+T + K+ Y PD+ GT Sbjct: 199 LL-ETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT 245
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 39.7 bits (91), Expect = 0.006 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETC--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 374 VLLGMEGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 414
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 39.7 bits (91), Expect = 0.006 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETC--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 374 VLLGMEGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 414
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 39.7 bits (91), Expect = 0.006 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETC--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 374 VLLGMEGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 414
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 39.7 bits (91), Expect = 0.006 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETC--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 374 VLLGMEGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 414
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 39.7 bits (91), Expect = 0.006 Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 5/158 (3%) Frame = +2 Query: 110 ILGGIHG--VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNS--HTMSVEMVACIAIEA 274 I+ G H + R++ + Y M+M+ LG LW + + +EA Sbjct: 411 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 470 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 + L HSKG ++ D+KPEN +L G + LVD G A K + + ++ Sbjct: 471 FAYL---HSKGIIYRDLKPENLILDHRGYAK-----LVDFGFAKK---------IGFGKK 513 Query: 455 PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 F GT Y + L + D SL + LL Sbjct: 514 TWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 551
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 39.7 bits (91), Expect = 0.006 Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 5/158 (3%) Frame = +2 Query: 110 ILGGIHG--VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNS--HTMSVEMVACIAIEA 274 I+ G H + R++ + Y M+M+ LG LW + + +EA Sbjct: 411 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 470 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 + L HSKG ++ D+KPEN +L G + LVD G A K + + ++ Sbjct: 471 FAYL---HSKGIIYRDLKPENLILDHRGYAK-----LVDFGFAKK---------IGFGKK 513 Query: 455 PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 F GT Y + L + D SL + LL Sbjct: 514 TWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 551
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 39.7 bits (91), Expect = 0.006 Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 5/158 (3%) Frame = +2 Query: 110 ILGGIHG--VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNS--HTMSVEMVACIAIEA 274 I+ G H + R++ + Y M+M+ LG LW + + +EA Sbjct: 411 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 470 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQR 454 + L HSKG ++ D+KPEN +L G + LVD G A K + + ++ Sbjct: 471 FAYL---HSKGIIYRDLKPENLILDHRGYAK-----LVDFGFAKK---------IGFGKK 513 Query: 455 PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFLL 568 F GT Y + L + D SL + LL Sbjct: 514 TWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 551
>E2AK3_CAEEL (Q19192) Eukaryotic translation initiation factor 2-alpha kinase| precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (CePEK) Length = 1077 Score = 39.7 bits (91), Expect = 0.006 Identities = 19/42 (45%), Positives = 26/42 (61%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 LE +H+KG++H D+KP N T + L + DLGLATK Sbjct: 921 LEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATK 962
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 39.7 bits (91), Expect = 0.006 Identities = 36/128 (28%), Positives = 57/128 (44%), Gaps = 8/128 (6%) Frame = +2 Query: 110 ILGGIHGVPR-VHYKG----RQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEA 274 IL + G P V +KG RQ + +M + G L+D H S A I + Sbjct: 132 ILQHLSGQPNIVEFKGVFEDRQSVHLVMEL-CAGGELFDRIIAQGH-YSERAAATICRQI 189 Query: 275 ISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV---EY 445 ++++ H G +H D+KPENFLL ++ L D GL+ +E ++ Y Sbjct: 190 VNVVHVCHFMGVMHRDLKPENFLLS--SKDKDAMLKATDFGLSVFIEEGKVYRNIVGSAY 247 Query: 446 DQRPDIFR 469 P++ R Sbjct: 248 YVAPEVLR 255
>BUB1_HUMAN (O43683) Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) (hBUB1) (BUB1A) Length = 1085 Score = 39.7 bits (91), Expect = 0.006 Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 6/62 (9%) Frame = +2 Query: 248 MVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKK------LFLVDLGLATK 409 +V A+ + ++E+VH +HGD+KP+NF+LG ++ + L L+DLG + Sbjct: 893 LVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSID 952 Query: 410 WK 415 K Sbjct: 953 MK 954
>PRKX_MOUSE (Q922R0) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (PKA-related protein kinase) Length = 355 Score = 39.3 bits (90), Expect = 0.008 Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 1/94 (1%) Frame = +2 Query: 146 YKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGD 322 + G + M+M+ + G L+ N SV V A E + +E +HSK V+ D Sbjct: 111 WTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVF-YATEIVCAIEYLHSKEIVYRD 169 Query: 323 VKPENFLLGPPGTPEEKKLFLVDLGLATKWKERS 424 +KPEN LL E + L D G A K +R+ Sbjct: 170 LKPENILL-----DREGHIKLTDFGFAKKLVDRT 198
>SKS1_YEAST (Q12505) Serine/threonine-protein kinase SKS1 (EC 2.7.11.1)| (Suppressor kinase of SNF3) Length = 502 Score = 39.3 bits (90), Expect = 0.008 Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 2/113 (1%) Frame = +2 Query: 83 PPYEWKVYDILGGIHG-VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVE-MVA 256 P Y + + HG + ++H +VMD L+ + ++ H ++ ++ Sbjct: 105 PHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYDRDLFTSIVDDKHFVNHGILIK 164 Query: 257 CIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK 415 + ++ S L+ H G H D+KPEN LL +L D GL+TK K Sbjct: 165 KVFLQLCSALDHCHRLGIYHCDIKPENVLL-----DRNDNAYLCDFGLSTKSK 212
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 39.3 bits (90), Expect = 0.008 Identities = 38/138 (27%), Positives = 58/138 (42%), Gaps = 1/138 (0%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 V R+ G GD+ +VM+ + G SL+D M + + L +H KG Sbjct: 73 VVRIVDFGESGDHACLVMEFVEGESLYDVLTPGP--MPPGRALPLLQQLAEGLAAIHDKG 130 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYA 487 +H D+KPEN + E+ + L+D G+A + E V + + GT Y Sbjct: 131 IIHRDLKPENVFISKSARGEQAR--LLDFGIA-RLVEPDAASSV---SQIGVVLGTPEYL 184 Query: 488 SVHAHLGRIGSRRDDLES 541 S +G R DL S Sbjct: 185 SPEQAVGAKVDTRSDLYS 202
>PIT1_SCHPO (O14132) Sporulation protein kinase pit1 (EC 2.7.11.1)| Length = 650 Score = 39.3 bits (90), Expect = 0.008 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +VM+ L +L+ + +++E V I + L +H+ G+ H D+KPEN L+ Sbjct: 112 IVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILISS 171 Query: 353 PGTPEEKKLFLVDLGLATKWKER 421 + + D GLA + R Sbjct: 172 NSDSSSFNVKIADFGLAREINSR 194
>CSK22_MOUSE (O54833) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 39.3 bits (90), Expect = 0.008 Identities = 20/45 (44%), Positives = 28/45 (62%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 E + L+ HSKG +H DVKP N ++ ++KKL L+D GLA Sbjct: 140 ELLKALDYCHSKGIMHRDVKPHNVMI----DHQQKKLRLIDWGLA 180
>CSK22_HUMAN (P19784) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 39.3 bits (90), Expect = 0.008 Identities = 20/45 (44%), Positives = 28/45 (62%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 E + L+ HSKG +H DVKP N ++ ++KKL L+D GLA Sbjct: 140 ELLKALDYCHSKGIMHRDVKPHNVMI----DHQQKKLRLIDWGLA 180
>CSK22_BOVIN (P20427) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 39.3 bits (90), Expect = 0.008 Identities = 20/45 (44%), Positives = 28/45 (62%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 E + L+ HSKG +H DVKP N ++ ++KKL L+D GLA Sbjct: 140 ELLKALDYCHSKGIMHRDVKPHNVMI----DHQQKKLRLIDWGLA 180
>CBK1_ASHGO (Q754N7) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 719 Score = 39.3 bits (90), Expect = 0.008 Identities = 29/116 (25%), Positives = 48/116 (41%), Gaps = 2/116 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 D+L G V ++Y + Y ++M+ L + ++ E I Sbjct: 360 DVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECIL 419 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 +E +H G++H D+KP+N L+ G + L D GL STG H +D Sbjct: 420 AIEAIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGL-------STGFHKTHD 463
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 39.3 bits (90), Expect = 0.008 Identities = 26/93 (27%), Positives = 40/93 (43%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 + +HY + D MV+D + S V A E +S L+ +H + Sbjct: 213 IVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIVSALDHLHKQDI 272 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 V+ D+KPEN LL G + + D GL+ K Sbjct: 273 VYRDLKPENILLDSEG-----HICITDFGLSKK 300
>CBK1_CANGA (Q6FP74) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 773 Score = 39.3 bits (90), Expect = 0.008 Identities = 28/116 (24%), Positives = 48/116 (41%), Gaps = 2/116 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 D+L G + ++Y + Y ++M+ L + ++ E I Sbjct: 420 DVLAGTDSPWIVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECIL 479 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 +E +H G++H D+KP+N L+ G + L D GL STG H +D Sbjct: 480 AIETIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGL-------STGFHKTHD 523
>PKN1_BACSU (P37562) Probable serine/threonine-protein kinase yabT (EC| 2.7.11.1) Length = 338 Score = 38.9 bits (89), Expect = 0.010 Identities = 21/71 (29%), Positives = 41/71 (57%), Gaps = 1/71 (1%) Frame = +2 Query: 245 EMVACIAIEAISILEKVHSKGYVHGDVKPENFLL-GPPGTPEEKKLFLVDLGLATKWKER 421 E + + I+ +S L +H +G++ GD+KP+N ++ GPP ++ +D+G TK + R Sbjct: 123 EWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPA-----RIRCIDVGGTTK-EGR 176 Query: 422 STGHHVEYDQR 454 + + E+ R Sbjct: 177 AIKEYTEFYDR 187
>MK11_MOUSE (Q9WUI1) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B) Length = 364 Score = 38.9 bits (89), Expect = 0.010 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 1/84 (1%) Frame = +2 Query: 236 MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK 415 +S E V + + + L+ +HS G +H D+KP N + E+ +L ++D GLA + Sbjct: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-----EDCELRILDFGLAPQAD 176 Query: 416 ERSTGH-HVEYDQRPDIFRGTVRY 484 E TG+ + + P+I + Y Sbjct: 177 EEMTGYVATRWYRAPEIMLNWMHY 200
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 38.9 bits (89), Expect = 0.010 Identities = 20/64 (31%), Positives = 33/64 (51%) Frame = +2 Query: 260 IAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV 439 + ++ +S LE +HS+G H D+KP N L+ GT + + D G+A ST Sbjct: 169 VVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVK-----ISDFGVAMSTATGSTNIQS 223 Query: 440 EYDQ 451 ++Q Sbjct: 224 SHEQ 227
>CBK1_DEBHA (Q6BLJ9) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 716 Score = 38.9 bits (89), Expect = 0.010 Identities = 28/116 (24%), Positives = 48/116 (41%), Gaps = 2/116 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 D+L G V ++Y + Y ++M+ L + ++ E + Sbjct: 365 DVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDITRFYMAECVL 424 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 +E +H G++H D+KP+N L+ G + L D GL STG H +D Sbjct: 425 AIEAIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGL-------STGFHKTHD 468
>MRCKA_RAT (O54874) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) Length = 1732 Score = 38.9 bits (89), Expect = 0.010 Identities = 27/100 (27%), Positives = 41/100 (41%), Gaps = 1/100 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 + +HY + + +VMD +G L + EM E + ++ VH Sbjct: 137 ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLH 196 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 YVH D+KP+N L+ G + L D G K E T Sbjct: 197 YVHRDIKPDNILMDMNG-----HIRLADFGSCLKLMEDGT 231
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 38.9 bits (89), Expect = 0.010 Identities = 21/67 (31%), Positives = 37/67 (55%) Frame = +2 Query: 158 QGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 +GD ++++ M G SL D ++ M+ + + E + L+ +HSKG +H D+K +N Sbjct: 1021 KGDLWVIMEYMEGGSLTDIVTHS--VMTEGQIGVVCRETLKGLKFLHSKGVIHRDIKSDN 1078 Query: 338 FLLGPPG 358 LL G Sbjct: 1079 ILLNMDG 1085
>KK31_SCHPO (Q9HFF4) Probable serine/threonine-protein kinase C110.01 (EC| 2.7.11.1) Length = 1023 Score = 38.9 bits (89), Expect = 0.010 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 8/116 (6%) Frame = +2 Query: 245 EMVAC-IAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKER 421 + VAC + + IS + +HS+G VH D+K EN LL + + + D G AT + Sbjct: 597 DSVACRLFAQLISGVAYLHSRGVVHRDLKLENILL-----DTNRNIVIADFGFATTFGHF 651 Query: 422 ST-GHHVEYDQRPDIFR---GTVRYAS---VHAHLGRIGSRRDDLESLAYTLVFLL 568 +T H ++PD+F G+ YA+ V+ G + D+ S L +L Sbjct: 652 NTLSEHSLPTEKPDLFSTSCGSPCYAAPELVNCKSGMYAGTQADIWSCGVILYAML 707
>CBK1_KLULA (P31034) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 718 Score = 38.9 bits (89), Expect = 0.010 Identities = 29/116 (25%), Positives = 48/116 (41%), Gaps = 2/116 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 D+L G V ++Y + Y ++M+ L + ++ E I Sbjct: 353 DVLAGSDSPWVVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECIL 412 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 +E +H G++H D+KP+N L+ G + L D GL STG H +D Sbjct: 413 AIEVIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGL-------STGFHKTHD 456
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 38.9 bits (89), Expect = 0.010 Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 3/106 (2%) Frame = +2 Query: 107 DILGGIHGVPRVHYKG---RQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAI 277 DIL +H V +K + ++I+ G L+D + V I +E + Sbjct: 88 DILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVR-ILVEIL 146 Query: 278 SILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK 415 S ++ +HS+ VH D+KPEN L +E L + D G+A + K Sbjct: 147 SAVKYMHSQNIVHRDLKPENLLY--IDKSDESPLVVADFGIAKRLK 190
>MKNK2_HUMAN (Q9HBH9) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 465 Score = 38.9 bits (89), Expect = 0.010 Identities = 25/103 (24%), Positives = 45/103 (43%) Frame = +2 Query: 101 VYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 +Y G + + + + + ++++ M G S+ H +E + + + S Sbjct: 133 LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELE-ASVVVQDVAS 191 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 L+ +H+KG H D+KPEN L P K+ DLG K Sbjct: 192 ALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 38.9 bits (89), Expect = 0.010 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 4/98 (4%) Frame = +2 Query: 203 LWDACCNN---SHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEK 373 L DA NN + +S + V + + + L+ +HS G +H D+KP N + E+ Sbjct: 111 LMDADLNNIIRTQKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVN-----EDC 165 Query: 374 KLFLVDLGLATKWKERSTGH-HVEYDQRPDIFRGTVRY 484 +L ++D GLA + TG+ + + P+I + Y Sbjct: 166 ELRILDFGLARPAESEMTGYVATRWYRAPEIMLNWMHY 203
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 38.9 bits (89), Expect = 0.010 Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 1/132 (0%) Frame = +2 Query: 176 MVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +VM++ G L D + + + + I+ ++++ H +G VH D+KPENFL Sbjct: 227 VVMELCEGGELLDRILSRGGKYTEDDAKAVMIQILNVVAFCHLQGVVHRDLKPENFLF-- 284 Query: 353 PGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDD 532 E+ +L +D GL+ +V+ D+R + G+ Y + L R S D Sbjct: 285 KSKDEDSQLKAIDFGLS---------DYVKPDERLNDIVGSAYYVAPEV-LHRSYSTEAD 334 Query: 533 LESLAYTLVFLL 568 + S+ LL Sbjct: 335 VWSIGVISYILL 346
>MKNK2_RAT (Q5U2N4) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 38.9 bits (89), Expect = 0.010 Identities = 25/103 (24%), Positives = 45/103 (43%) Frame = +2 Query: 101 VYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 +Y G + + + + + ++++ M G S+ H +E + + + S Sbjct: 133 LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELE-ASVVVQDVAS 191 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 L+ +H+KG H D+KPEN L P K+ DLG K Sbjct: 192 ALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
>MKNK2_MOUSE (Q8CDB0) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 38.9 bits (89), Expect = 0.010 Identities = 25/103 (24%), Positives = 45/103 (43%) Frame = +2 Query: 101 VYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 +Y G + + + + + ++++ M G S+ H +E + + + S Sbjct: 133 LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELE-ASVVVQDVAS 191 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATK 409 L+ +H+KG H D+KPEN L P K+ DLG K Sbjct: 192 ALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
>PKNG_MYCLE (P57993) Probable serine/threonine-protein kinase pknG (EC| 2.7.11.1) Length = 763 Score = 38.9 bits (89), Expect = 0.010 Identities = 38/150 (25%), Positives = 59/150 (39%) Frame = +2 Query: 20 PGAVEVALKFEHKDSKGCSHGPPYEWKVYDILGGIHGVPRVHYKGRQGDYFIMVMDMLGF 199 P V++ EHKD+ G P + V + +GG + R KG Sbjct: 217 PQIVQIFNFVEHKDTSG----DPVGYIVMEYIGG-RSLKRGSKKG--------------- 256 Query: 200 SLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKL 379 N + V +E + L +HS G V+ D+KPEN +L E++L Sbjct: 257 --------NVEKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIML------TEEQL 302 Query: 380 FLVDLGLATKWKERSTGHHVEYDQRPDIFR 469 L+DLG ++ + Q P+I R Sbjct: 303 KLIDLGAVSRINSFGCIYGTPGYQAPEIVR 332
>PKSC_STRCO (Q9S2C0) Serine/threonine protein kinase pksC (EC 2.7.11.1)| Length = 556 Score = 38.5 bits (88), Expect = 0.014 Identities = 33/123 (26%), Positives = 51/123 (41%) Frame = +2 Query: 200 SLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKL 379 S+ D M + I + ++ LE H G VH D+KP N ++ G + Sbjct: 111 SVLDEDVRQQGAMPADKALKITADVLAALEISHEMGLVHRDIKPGNVMMTKRGVVK---- 166 Query: 380 FLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLAYTLV 559 ++D G+A R+ V + + GT +Y S LGR R DL S+ L Sbjct: 167 -VMDFGIA-----RAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLF 220 Query: 560 FLL 568 L+ Sbjct: 221 QLV 223
>M3K8_RAT (Q63562) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (Tumor progression locus 2) (TPL-2) Length = 467 Score = 38.5 bits (88), Expect = 0.014 Identities = 30/94 (31%), Positives = 41/94 (43%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI 463 L+ +HSK +H D+KP N + K LVD GL+ + E P Sbjct: 241 LDFLHSKKVIHHDIKPSNIVF------MSTKAVLVDFGLSVQMTEDV--------YLPKD 286 Query: 464 FRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFL 565 RGT Y S L R S + D+ SL TL+ + Sbjct: 287 LRGTEIYMSPEVILCRGHSTKADIYSLGATLIHM 320
>M3K8_HUMAN (P41279) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene) Length = 467 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/94 (32%), Positives = 43/94 (45%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDI 463 L+ +HSK +H D+KP N + K LVD GL+ + E V + P Sbjct: 241 LDFLHSKKVIHHDIKPSNIVF------MSTKAVLVDFGLSVQMTE-----DVYF---PKD 286 Query: 464 FRGTVRYASVHAHLGRIGSRRDDLESLAYTLVFL 565 RGT Y S L R S + D+ SL TL+ + Sbjct: 287 LRGTEIYMSPEVILCRGHSTKADIYSLGATLIHM 320
>PKND_CHLTR (O84303) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 38.5 bits (88), Expect = 0.014 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 15/125 (12%) Frame = +2 Query: 239 SVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA----- 403 SV+ I + + +E +HSKG +H D+KP+N LLG G ++ ++D G A Sbjct: 111 SVKSFLPIFDKICATVEYIHSKGVLHRDLKPDNILLGLFG-----EVVIIDWGAAIFKHA 165 Query: 404 -TKWKERSTGHHVEYDQR---------PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYT 553 E+ V +D+R P GT Y + + LG S + D+ +L Sbjct: 166 KELKLEQDDEAAVSFDERNICYSSMTIPGKIVGTPDYMAPESLLGVEASEKTDIYALGLI 225 Query: 554 LVFLL 568 L +L Sbjct: 226 LYQML 230
>PKND_CHLMU (Q9PK92) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 38.5 bits (88), Expect = 0.014 Identities = 35/125 (28%), Positives = 55/125 (44%), Gaps = 15/125 (12%) Frame = +2 Query: 239 SVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA----- 403 SV+ I + + +E +HSKG +H D+KP+N LLG G ++ +VD G A Sbjct: 111 SVKAFLPIFDKICATVEYIHSKGVLHRDLKPDNILLGLFG-----EVVIVDWGAAIFKHA 165 Query: 404 -TKWKERSTGHHVEYDQR---------PDIFRGTVRYASVHAHLGRIGSRRDDLESLAYT 553 +E+ Y Q+ P GT Y + + LG S + D+ +L Sbjct: 166 KELQQEKDEEGFSSYGQKNICYSSMTVPGKIVGTPDYMAPESLLGAEASEKTDIYALGLI 225 Query: 554 LVFLL 568 L +L Sbjct: 226 LYQML 230
>ROCK2_MOUSE (P70336) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 38.5 bits (88), Expect = 0.014 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 1/90 (1%) Frame = +2 Query: 167 YFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 Y MVM+ M G L + N + + + E + L+ +HS G +H DVKP+N L Sbjct: 164 YLYMVMEYMPGGDLVNLMSN--YDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNML 221 Query: 344 LGPPGTPEEKKLFLVDLGLATKWKERSTGH 433 L G L L D G K E H Sbjct: 222 LDKHG-----HLKLADFGTCMKMDETGMVH 246
>ROCK2_BOVIN (Q28021) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 38.5 bits (88), Expect = 0.014 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 1/90 (1%) Frame = +2 Query: 167 YFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 Y MVM+ M G L + N + + + E + L+ +HS G +H DVKP+N L Sbjct: 164 YLYMVMEYMPGGDLVNLMSN--YDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNML 221 Query: 344 LGPPGTPEEKKLFLVDLGLATKWKERSTGH 433 L G L L D G K E H Sbjct: 222 LDKHG-----HLKLADFGTCMKMDETGMVH 246
>HIPK2_MOUSE (Q9QZR5) Homeodomain-interacting protein kinase 2 (EC 2.7.11.1)| (Nuclear body-associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase) Length = 1196 Score = 38.5 bits (88), Expect = 0.014 Identities = 27/102 (26%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++ + + + + L K+ S G +H D+KPEN +L Sbjct: 275 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD 334 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + + ++ ++D G A+ + ST Y + P+I G Sbjct: 335 P-SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
>PKH3_YEAST (Q03306) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| (Pkb-activating kinase homolog 3) Length = 898 Score = 38.5 bits (88), Expect = 0.014 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 9/83 (10%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEY- 445 + I LE +HS G +H D+KPEN LL G +L + D G A +G ++ Sbjct: 121 QLIDALEFIHSHGIIHRDLKPENVLLDRDG-----RLMITDFGAAATIDPSLSGDSAKFN 175 Query: 446 --------DQRPDIFRGTVRYAS 490 +Q F GT Y S Sbjct: 176 SDSNGSKDNQNCASFVGTAEYVS 198
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + L+ +HS +H D+K +N Sbjct: 335 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 393 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 433
>HIPK2_HUMAN (Q9H2X6) Homeodomain-interacting protein kinase 2 (EC 2.7.11.1)| (hHIPk2) Length = 1198 Score = 38.5 bits (88), Expect = 0.014 Identities = 27/102 (26%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++ + + + + L K+ S G +H D+KPEN +L Sbjct: 275 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD 334 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + + ++ ++D G A+ + ST Y + P+I G Sbjct: 335 P-SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
>MAST3_HUMAN (O60307) Microtubule-associated serine/threonine-protein kinase 3| (EC 2.7.11.1) Length = 1309 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 3/109 (2%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLL 346 + MVM+ + N + V+M E + LE +H+ G VH D+KP+N L+ Sbjct: 439 HLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLI 498 Query: 347 GPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFR---GTVRY 484 G + L +GL + G H+E D R I + GT Y Sbjct: 499 TSLGHIKLTDFGLSKIGLMSMATNLYEG-HIEKDAREFIDKQVCGTPEY 546
>HIPK1_MOUSE (O88904) Homeodomain-interacting protein kinase 1 (EC 2.7.11.1)| (Protein kinase Myak) (Nuclear body-associated kinase 2) Length = 1210 Score = 38.5 bits (88), Expect = 0.014 Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++ + I + + L K+ S G +H D+KPEN +L Sbjct: 266 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 325 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + ++ ++D G A+ + ST Y + P+I G Sbjct: 326 P-VRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
>HIPK1_HUMAN (Q86Z02) Homeodomain-interacting protein kinase 1 (EC 2.7.11.1)| Length = 1210 Score = 38.5 bits (88), Expect = 0.014 Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++ + I + + L K+ S G +H D+KPEN +L Sbjct: 266 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 325 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + ++ ++D G A+ + ST Y + P+I G Sbjct: 326 P-VRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
>HIPK2_MESAU (Q9WUM7) Homeodomain-interacting protein kinase 2 (EC 2.7.11.1)| (Mx-interacting protein kinase) (PKM) Length = 1168 Score = 38.5 bits (88), Expect = 0.014 Identities = 27/102 (26%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Frame = +2 Query: 176 MVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGP 352 +V +ML +L+D N + + ++ + + + + L K+ S G +H D+KPEN +L Sbjct: 275 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD 334 Query: 353 PGTPEEKKLFLVDLGLATKWKER--STGHHVEYDQRPDIFRG 472 P + + ++ ++D G A+ + ST Y + P+I G Sbjct: 335 P-SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
>ROCK2_RAT (Q62868) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) Length = 1379 Score = 38.5 bits (88), Expect = 0.014 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 1/90 (1%) Frame = +2 Query: 167 YFIMVMD-MLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 Y MVM+ M G L + N + + + E + L+ +HS G +H DVKP+N L Sbjct: 155 YLYMVMEYMPGGDLVNLMSN--YDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNML 212 Query: 344 LGPPGTPEEKKLFLVDLGLATKWKERSTGH 433 L G L L D G K E H Sbjct: 213 LDKHG-----HLKLADFGTCMKMDETGMVH 237
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 38.5 bits (88), Expect = 0.014 Identities = 34/140 (24%), Positives = 49/140 (35%), Gaps = 10/140 (7%) Frame = +2 Query: 14 KAPGAVEVALKFEHKDSKGCSHGPPYEWKVYD----------ILGGIHGVPRVHYKGRQG 163 K P + +F + + S P+ +VYD ++ +HGV H QG Sbjct: 51 KGPHREQFVERFRREANSAASIANPHIVQVYDTGEFNGLDFLVMEYVHGVNLRHEMNAQG 110 Query: 164 DYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 T SV + E + L H G VH D+KPEN L Sbjct: 111 -----------------------TFSVRETLRVVAETLDGLASAHRAGVVHRDIKPENIL 147 Query: 344 LGPPGTPEEKKLFLVDLGLA 403 + G + + D GLA Sbjct: 148 INDRGHVQ-----ITDFGLA 162
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + L+ +HS +H D+K +N Sbjct: 350 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 408 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 448
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + L+ +HS +H D+K +N Sbjct: 350 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 408 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 448
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + L+ +HS +H D+K +N Sbjct: 350 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 408 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 448
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 38.5 bits (88), Expect = 0.014 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 5/106 (4%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 GD +VM+ L G SL D M +A + E + L+ +HS +H D+K +N Sbjct: 350 GDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407 Query: 338 FLLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G + + +RST Y P++ Sbjct: 408 ILLGMDGSVK-----LTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 448
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 38.1 bits (87), Expect = 0.018 Identities = 24/80 (30%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAI-SILEKVHSKGYVHGDVKPENFL 343 Y++++ + G L+D + E A + I+ + S ++ +H G VH D+KPEN L Sbjct: 93 YYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLL 150 Query: 344 LGPPGTPEEKKLFLVDLGLA 403 P E K+ + D GL+ Sbjct: 151 YLTP--EENSKIMITDFGLS 168
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 38.1 bits (87), Expect = 0.018 Identities = 24/80 (30%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAI-SILEKVHSKGYVHGDVKPENFL 343 Y++++ + G L+D + E A + I+ + S ++ +H G VH D+KPEN L Sbjct: 93 YYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLL 150 Query: 344 LGPPGTPEEKKLFLVDLGLA 403 P E K+ + D GL+ Sbjct: 151 YLTP--EENSKIMITDFGLS 168
>MK14A_DROME (O62618) Mitogen-activated protein kinase 14A (EC 2.7.11.24) (MAP| kinase p38a) (p38 MAPK) (Dp38) (D-p38a) Length = 366 Score = 38.1 bits (87), Expect = 0.018 Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 4/98 (4%) Frame = +2 Query: 203 LWDACCNNSHTM---SVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEK 373 L DA NN M S + V + + + L+ +HS G +H D+KP N + E+ Sbjct: 112 LMDADLNNIIRMQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVN-----EDC 166 Query: 374 KLFLVDLGLATKWKERSTGH-HVEYDQRPDIFRGTVRY 484 +L ++D GLA + TG+ + + P+I + Y Sbjct: 167 ELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWMHY 204
>CSK22_YEAST (P19454) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 338 Score = 38.1 bits (87), Expect = 0.018 Identities = 19/40 (47%), Positives = 26/40 (65%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 L+ HS G +H DVKP+N ++ P E+KL L+D GLA Sbjct: 154 LDYCHSMGIMHRDVKPQNVMI----DPTERKLRLIDWGLA 189
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 38.1 bits (87), Expect = 0.018 Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 5/105 (4%) Frame = +2 Query: 164 DYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENF 340 D +VM+ L G SL D M ++A + E + LE +HS+ +H D+K +N Sbjct: 363 DELWVVMEYLAGGSLTDVVTECQ--MEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNI 420 Query: 341 LLGPPGTPEEKKLFLVDLG----LATKWKERSTGHHVEYDQRPDI 463 LLG G+ + L D G L+ + ++R+T Y P++ Sbjct: 421 LLGMDGSVK-----LTDFGFCAQLSPEQRKRTTMVGTPYWMAPEV 460
>LKH1_SCHPO (Q10156) Dual specificity protein kinase lkh1 (EC 2.7.12.1)| Length = 575 Score = 38.1 bits (87), Expect = 0.018 Identities = 19/61 (31%), Positives = 36/61 (59%), Gaps = 1/61 (1%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFL 343 + +V D+ G+S++D NN++ ++ + ++ + + +HS G VH D+KPEN L Sbjct: 321 HICIVTDLFGWSVFDFLKNNNYIPFPLKHIQMLSQQLFKSVAFLHSLGLVHTDLKPENVL 380 Query: 344 L 346 L Sbjct: 381 L 381
>JIL1_DROME (Q9V3I5) Chromosomal serine/threonine-protein kinase JIL-1 (EC| 2.7.11.1) Length = 1207 Score = 38.1 bits (87), Expect = 0.018 Identities = 18/60 (30%), Positives = 33/60 (55%), Gaps = 6/60 (10%) Frame = +2 Query: 260 IAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA------TKWKER 421 I ++ + + +HSK ++HGD+KPEN + E++ + L+D G A WK++ Sbjct: 719 IFLQLVMAVRHIHSKHFIHGDLKPENIMF---ENREDRTVKLIDFGSACYNNRFKSWKDK 775
>LATS1_HUMAN (O95835) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Length = 1130 Score = 38.1 bits (87), Expect = 0.018 Identities = 29/112 (25%), Positives = 44/112 (39%), Gaps = 6/112 (5%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V R++Y + D VMD + + + E +E VH G+ Sbjct: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLAT--KW----KERSTGHHVEYD 448 +H D+KP+N L+ G + L D GL T +W K +G H D Sbjct: 825 IHRDIKPDNILIDRDG-----HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQD 871
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 38.1 bits (87), Expect = 0.018 Identities = 30/95 (31%), Positives = 43/95 (45%) Frame = +2 Query: 263 AIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVE 442 A E +S +E +HS G +H D+KPEN L G K + D G A K + + Sbjct: 159 AAEILSSIEYMHSCGIIHRDLKPENILF--DGNMHVK---ITDFGTA-KILPPKYVNSPD 212 Query: 443 YDQRPDIFRGTVRYASVHAHLGRIGSRRDDLESLA 547 Y P F GT Y + ++ S+ DL + A Sbjct: 213 YTTFPSSFVGTAEYVAPELLSRQVVSKSSDLWAFA 247
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 38.1 bits (87), Expect = 0.018 Identities = 24/80 (30%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = +2 Query: 167 YFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAI-SILEKVHSKGYVHGDVKPENFL 343 Y++++ + G L+D + E A + I+ + S ++ +H G VH D+KPEN L Sbjct: 93 YYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLL 150 Query: 344 LGPPGTPEEKKLFLVDLGLA 403 P E K+ + D GL+ Sbjct: 151 YLTP--EENSKIMITDFGLS 168
>SPK1_CAEBR (Q61IS6) Serine/threonine-protein kinase spk-1 (EC 2.7.11.1)| Length = 771 Score = 38.1 bits (87), Expect = 0.018 Identities = 28/98 (28%), Positives = 48/98 (48%), Gaps = 2/98 (2%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSK-GYVHGDV 325 G G + MV ++LG +L +++ + +E V I + + L +H K G +H D+ Sbjct: 209 GINGQHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICKQILEALRYMHEKCGIIHTDI 268 Query: 326 KPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV 439 KPEN L+ + EE K+ +A K + +G V Sbjct: 269 KPENVLI--TMSREEIKIMAQHAVVARKMNMKMSGSAV 304
>MRCKB_HUMAN (Q9Y5S2) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1711 Score = 38.1 bits (87), Expect = 0.018 Identities = 26/105 (24%), Positives = 43/105 (40%), Gaps = 1/105 (0%) Frame = +2 Query: 116 GGIHGVPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISILEK 292 G + +HY + ++ +VMD +G L + +M E + ++ Sbjct: 131 GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDS 190 Query: 293 VHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 +H YVH D+KP+N LL G + L D G K + T Sbjct: 191 IHQLHYVHRDIKPDNVLLDVNG-----HIRLADFGSCLKMNDDGT 230
>CSK2A_NEUCR (Q8TG13) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 336 Score = 38.1 bits (87), Expect = 0.018 Identities = 20/45 (44%), Positives = 27/45 (60%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 E + L+ HSKG +H DVKP N ++ E +KL L+D GLA Sbjct: 132 ELLKALDFCHSKGIMHRDVKPHNVMI----DHENRKLRLIDWGLA 172
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 38.1 bits (87), Expect = 0.018 Identities = 29/118 (24%), Positives = 52/118 (44%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 + ++HY + +++D L + + E V E L+ +HS G Sbjct: 130 IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI 189 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRY 484 ++ D+KPEN LL EE + L D GL+ + ++++++ F GTV Y Sbjct: 190 IYRDLKPENILL-----DEEGHIKLTDFGLSKE--------SIDHEKKAYSFCGTVEY 234 Score = 30.8 bits (68), Expect = 2.8 Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 2/83 (2%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 G Y +V +++ G L D S + + +E +H++G VH D+KP N Sbjct: 486 GKYVYVVTELMKGGELLDKILRQKF-FSEREASAVLFTITKTVEYLHAQGVVHRDLKPSN 544 Query: 338 FL-LGPPGTPEEKKLFLVDLGLA 403 L + G PE + + D G A Sbjct: 545 ILYVDESGNPE--SIRICDFGFA 565
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 38.1 bits (87), Expect = 0.018 Identities = 29/118 (24%), Positives = 52/118 (44%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 + ++HY + +++D L + + E V E L+ +HS G Sbjct: 130 IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI 189 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPDIFRGTVRY 484 ++ D+KPEN LL EE + L D GL+ + ++++++ F GTV Y Sbjct: 190 IYRDLKPENILL-----DEEGHIKLTDFGLSKE--------SIDHEKKAYSFCGTVEY 234 Score = 30.8 bits (68), Expect = 2.8 Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 2/83 (2%) Frame = +2 Query: 161 GDYFIMVMDML-GFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPEN 337 G Y +V +++ G L D S + + +E +H++G VH D+KP N Sbjct: 486 GKYVYVVTELMKGGELLDKILRQKF-FSEREASAVLFTITKTVEYLHAQGVVHRDLKPSN 544 Query: 338 FL-LGPPGTPEEKKLFLVDLGLA 403 L + G PE + + D G A Sbjct: 545 ILYVDESGNPE--SIRICDFGFA 565
>PK1_ASFM2 (P34206) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 299 Score = 38.1 bits (87), Expect = 0.018 Identities = 16/53 (30%), Positives = 32/53 (60%) Frame = +2 Query: 260 IAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKE 418 I + I I++ ++ KG++HGD+K EN ++ ++K + ++D G A + E Sbjct: 133 IIFQMILIIQNIYEKGFIHGDIKDENLII----DIDQKIIKVIDFGSAVRLNE 181
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 38.1 bits (87), Expect = 0.018 Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 1/88 (1%) Frame = +2 Query: 224 NSHTMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLA 403 NS + + + + + L+ +HS G +H D+KP N L+ E L + D GLA Sbjct: 112 NSRPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILIN-----ENCDLKICDFGLA 166 Query: 404 TKWKERSTGH-HVEYDQRPDIFRGTVRY 484 + TG+ Y + P+I +Y Sbjct: 167 RLQDPQMTGYVSTRYYRAPEIMLTWQKY 194
>LATS1_MOUSE (Q8BYR2) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) Length = 1129 Score = 38.1 bits (87), Expect = 0.018 Identities = 29/112 (25%), Positives = 44/112 (39%), Gaps = 6/112 (5%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKGY 310 V R++Y + D VMD + + + E +E VH G+ Sbjct: 764 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF 823 Query: 311 VHGDVKPENFLLGPPGTPEEKKLFLVDLGLAT--KW----KERSTGHHVEYD 448 +H D+KP+N L+ G + L D GL T +W K +G H D Sbjct: 824 IHRDIKPDNILIDRDG-----HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQD 870
>STK38_MOUSE (Q91VJ4) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 38.1 bits (87), Expect = 0.018 Identities = 21/71 (29%), Positives = 34/71 (47%) Frame = +2 Query: 233 TMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKW 412 T++ E E + ++ +H G++H D+KP+N LL G + L D GL T Sbjct: 183 TLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKG-----HVKLSDFGLCTGL 237 Query: 413 KERSTGHHVEY 445 K+ H E+ Sbjct: 238 KK---AHRTEF 245
>STK38_HUMAN (Q15208) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 38.1 bits (87), Expect = 0.018 Identities = 21/71 (29%), Positives = 34/71 (47%) Frame = +2 Query: 233 TMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKW 412 T++ E E + ++ +H G++H D+KP+N LL G + L D GL T Sbjct: 183 TLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKG-----HVKLSDFGLCTGL 237 Query: 413 KERSTGHHVEY 445 K+ H E+ Sbjct: 238 KK---AHRTEF 245
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 37.7 bits (86), Expect = 0.023 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 2/128 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 DIL ++ V ++HY + +++D L + + E V E Sbjct: 132 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 191 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD 460 L+ +HS G ++ D+KPEN LL EE + L D GL+ + ++++++ Sbjct: 192 GLDHLHSLGIIYRDLKPENILL-----DEEGHIKLTDFGLSKE--------AIDHEKKAY 238 Query: 461 IFRGTVRY 484 F GTV Y Sbjct: 239 SFCGTVEY 246 Score = 31.2 bits (69), Expect = 2.2 Identities = 17/41 (41%), Positives = 24/41 (58%), Gaps = 1/41 (2%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFL-LGPPGTPEEKKLFLVDLGLA 403 +E +HS+G VH D+KP N L + G PE + + D G A Sbjct: 540 VEYLHSQGVVHRDLKPSNILYVDESGNPE--SIRICDFGFA 578
>SPK1_CAEEL (Q03563) Serine/threonine-protein kinase spk-1 (EC 2.7.11.1)| Length = 1003 Score = 37.7 bits (86), Expect = 0.023 Identities = 28/98 (28%), Positives = 48/98 (48%), Gaps = 2/98 (2%) Frame = +2 Query: 152 GRQGDYFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSK-GYVHGDV 325 G G + MV ++LG +L +++ + +E V I + + L +H K G +H D+ Sbjct: 497 GINGQHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDI 556 Query: 326 KPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHV 439 KPEN L+ + EE K+ +A K + +G V Sbjct: 557 KPENVLI--TMSREEIKIMAQHAVVARKMNMKMSGSAV 592
>MRCKA_HUMAN (Q5VT25) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha Length = 1732 Score = 37.7 bits (86), Expect = 0.023 Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 1/100 (1%) Frame = +2 Query: 131 VPRVHYKGRQGDYFIMVMDM-LGFSLWDACCNNSHTMSVEMVACIAIEAISILEKVHSKG 307 + +HY + + +VMD +G L + +M E + ++ VH Sbjct: 137 ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLH 196 Query: 308 YVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERST 427 YVH D+KP+N L+ G + L D G K E T Sbjct: 197 YVHRDIKPDNILMDMNG-----HIRLADFGSCLKLMEDGT 231
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 37.7 bits (86), Expect = 0.023 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 2/128 (1%) Frame = +2 Query: 107 DILGGIHG--VPRVHYKGRQGDYFIMVMDMLGFSLWDACCNNSHTMSVEMVACIAIEAIS 280 DIL ++ V ++HY + +++D L + + E V E Sbjct: 114 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 173 Query: 281 ILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYDQRPD 460 L+ +HS G ++ D+KPEN LL EE + L D GL+ + ++++++ Sbjct: 174 GLDHLHSLGIIYRDLKPENILL-----DEEGHIKLTDFGLSKE--------AIDHEKKAY 220 Query: 461 IFRGTVRY 484 F GTV Y Sbjct: 221 SFCGTVEY 228 Score = 31.6 bits (70), Expect = 1.7 Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 2/55 (3%) Frame = +2 Query: 245 EMVACIAIEAIS-ILEKVHSKGYVHGDVKPENFL-LGPPGTPEEKKLFLVDLGLA 403 E A + IS +E +HS+G VH D+KP N L + G PE L + D G A Sbjct: 498 EREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPE--CLRICDFGFA 550
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 37.7 bits (86), Expect = 0.023 Identities = 18/42 (42%), Positives = 26/42 (61%) Frame = +2 Query: 293 VHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKE 418 +H+ G H D+KPEN L PGT + K+ + D GLA+ K+ Sbjct: 208 LHALGITHRDLKPENLLYYHPGT--DSKIIITDFGLASARKK 247
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 37.7 bits (86), Expect = 0.023 Identities = 18/42 (42%), Positives = 26/42 (61%) Frame = +2 Query: 293 VHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKE 418 +H+ G H D+KPEN L PGT + K+ + D GLA+ K+ Sbjct: 208 LHALGITHRDLKPENLLYYHPGT--DSKIIITDFGLASARKK 247
>DYRK3_HUMAN (O43781) Dual specificity tyrosine-phosphorylation-regulated kinase| 3 (EC 2.7.12.1) Length = 588 Score = 37.7 bits (86), Expect = 0.023 Identities = 28/111 (25%), Positives = 54/111 (48%), Gaps = 2/111 (1%) Frame = +2 Query: 164 DYFIMVMDMLGFSLWDACCNNSHT-MSVEMVACIAIEAISILEKVHSKGYVHGDVKPENF 340 ++ M ++L L++ N SV++V A + L+ +H +H D+KPEN Sbjct: 282 NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENI 341 Query: 341 LLGPPGTPEEKKLFLVDLGLAT-KWKERSTGHHVEYDQRPDIFRGTVRYAS 490 LL G K ++D G + ++++ T + + P+I G+ RY++ Sbjct: 342 LLKHHGRSSTK---VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS-RYST 388
>CSK2A_DICDI (Q02720) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 337 Score = 37.7 bits (86), Expect = 0.023 Identities = 21/63 (33%), Positives = 36/63 (57%) Frame = +2 Query: 269 EAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERSTGHHVEYD 448 E + L+ HS G +H DVKP N ++ +++KL+L+D GLA ++ + ++V Sbjct: 147 ELLHALDFCHSNGIMHRDVKPSNVMI----DHQKRKLYLIDWGLA-EFYHPNQDYNVRVA 201 Query: 449 QRP 457 RP Sbjct: 202 SRP 204
>ST38L_MOUSE (Q7TSE6) Serine/threonine-protein kinase 38-like (EC 2.7.11.1)| (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Length = 464 Score = 37.7 bits (86), Expect = 0.023 Identities = 22/71 (30%), Positives = 34/71 (47%) Frame = +2 Query: 233 TMSVEMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKW 412 T++ E E + ++ +H G++H DVKP+N LL G + L D GL T Sbjct: 184 TLTEEETQFYISETVLAIDAIHQLGFIHRDVKPDNLLLDAKG-----HVKLSDFGLCTGL 238 Query: 413 KERSTGHHVEY 445 K+ H E+ Sbjct: 239 KK---AHRTEF 246
>CHK1_USTMA (P0C198) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 662 Score = 37.7 bits (86), Expect = 0.023 Identities = 19/44 (43%), Positives = 25/44 (56%) Frame = +2 Query: 284 LEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWK 415 LE +HS+G H D+KPEN LL G L + D GL + +K Sbjct: 181 LEYIHSQGVTHRDIKPENMLLDAEG-----NLKIADFGLCSVYK 219
>MK11_HUMAN (Q15759) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase 2) Length = 372 Score = 37.7 bits (86), Expect = 0.023 Identities = 23/81 (28%), Positives = 41/81 (50%), Gaps = 1/81 (1%) Frame = +2 Query: 245 EMVACIAIEAISILEKVHSKGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATKWKERS 424 E V + + + L+ +HS G +H D+KP N + E+ +L ++D GLA + E Sbjct: 133 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-----EDCELRILDFGLARQADEEM 187 Query: 425 TGH-HVEYDQRPDIFRGTVRY 484 TG+ + + P+I + Y Sbjct: 188 TGYVATRWYRAPEIMLNWMHY 208 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 91,562,530 Number of Sequences: 219361 Number of extensions: 2076891 Number of successful extensions: 6763 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6431 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6660 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4757699440 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
