ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | baal30e04 |
|---|---|
| Clone Library Name | barley_pub |
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 72.4 bits (176), Expect = 1e-12 Identities = 51/135 (37%), Positives = 75/135 (55%), Gaps = 12/135 (8%) Frame = +1 Query: 232 QHKSSGI-------ESTPA----EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR 378 QH S+G+ ST A ++ +L G+ +K +++ +KELGSG +G V GKW+ Sbjct: 378 QHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWK 437 Query: 379 G-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLA 555 G DVA+K IK +G SE E F++EAQ + L HP +V FYGV + + Sbjct: 438 GQYDVAVKMIK----EGSMSEDE-----FFQEAQTMMKLSHPKLVKFYGVC--SKEYPIY 486 Query: 556 TVTEFMVNGSLKQFL 600 VTE++ NG L +L Sbjct: 487 IVTEYISNGCLLNYL 501
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 69.7 bits (169), Expect = 7e-12 Identities = 50/135 (37%), Positives = 73/135 (54%), Gaps = 12/135 (8%) Frame = +1 Query: 232 QHKSSGI-------ESTPAE----AEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR 378 QH S+G+ ST A + AL G+ +K +++ +KELG+G +G V G+W+ Sbjct: 354 QHNSAGMITRLRHPVSTKANKVPVSVALGSGIWELKREEITLLKELGNGQFGVVQLGQWK 413 Query: 379 G-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLA 555 G DVA+K IK +G SE E F++EAQ + L HP +V FYGV + Sbjct: 414 GQYDVAVKMIK----EGAMSEDE-----FFQEAQTMMKLSHPKLVKFYGVC--SKKYPIY 462 Query: 556 TVTEFMVNGSLKQFL 600 VTE++ NG L +L Sbjct: 463 IVTEYITNGCLLNYL 477
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 66.2 bits (160), Expect = 8e-11 Identities = 41/97 (42%), Positives = 51/97 (52%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 ++LE + +G G +G V G WR DVAIK I F + S + F E ILS Sbjct: 1287 NELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSS-----LVMFQNEVGILSK 1341 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPNVV F G G + VTE+M GSL+QFL Sbjct: 1342 LRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFL 1378
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 65.9 bits (159), Expect = 1e-10 Identities = 50/136 (36%), Positives = 70/136 (51%), Gaps = 13/136 (9%) Frame = +1 Query: 232 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 375 QH S+G+ ++ P+ A L G I DL +KELG+G +G V +GKW Sbjct: 362 QHNSAGLISRLKYPVSQQNKNAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 420 Query: 376 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSL 552 RG DVAIK IK +G SE E F +EA+++ +L H +V YGV + Sbjct: 421 RGQYDVAIKMIK----EGSMSEDE-----FIEEAKVMMNLSHEKLVQLYGVCT--KQRPI 469 Query: 553 ATVTEFMVNGSLKQFL 600 +TE+M NG L +L Sbjct: 470 FIITEYMANGCLLNYL 485
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 64.7 bits (156), Expect = 2e-10 Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 1/122 (0%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC-DVAIKRIKAS 414 KSS + LS I +L ++ELGSG +G V GKWRG D A+K +K Sbjct: 500 KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK-- 557 Query: 415 CFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQ 594 +G SE DF +EA++++ L HPN+V YGV + VTE+M +GSL Sbjct: 558 --EGTMSED-----DFIEEAKVMTKLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGSLLN 608 Query: 595 FL 600 +L Sbjct: 609 YL 610
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/136 (36%), Positives = 70/136 (51%), Gaps = 13/136 (9%) Frame = +1 Query: 232 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 375 QH S+G+ ++ P+ A L G I DL +KELG+G +G V +GKW Sbjct: 362 QHNSAGLISRLKYPVSKQNKNAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 420 Query: 376 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSL 552 RG DVAIK I+ +G SE E F +EA+++ +L H +V YGV + Sbjct: 421 RGQYDVAIKMIR----EGSMSEDE-----FIEEAKVMMNLSHEKLVQLYGVCT--KQRPI 469 Query: 553 ATVTEFMVNGSLKQFL 600 +TE+M NG L +L Sbjct: 470 FIITEYMANGCLLNYL 485
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 64.7 bits (156), Expect = 2e-10 Identities = 44/149 (29%), Positives = 69/149 (46%) Frame = +1 Query: 154 DNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKE 333 D+ G D N D + D+ D K ++ + I D++ K+ Sbjct: 1316 DDTDSGTADDSNYDSGKIIDIDYMADIDKEDSFLTSANMCRWI------INYDEISIGKQ 1369 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +G G+YG VF+GKW+G DVA+K+ + E + +F E LS L H N+V+ Sbjct: 1370 IGLGSYGIVFNGKWKGVDVAVKKFV------KQKLSETQLLEFRAEMAFLSELKHSNIVT 1423 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G P ++ VTE+M G+L+ L Sbjct: 1424 FIGACIKKP--NICIVTEYMRMGNLRDVL 1450 Score = 57.8 bits (138), Expect = 3e-08 Identities = 42/113 (37%), Positives = 58/113 (51%), Gaps = 6/113 (5%) Frame = +1 Query: 280 LSKGLQTIKND------DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSER 441 L K T ND +LE + LG+G YG V+ W+G +VA+K I +S + ER Sbjct: 768 LLKHRNTTNNDWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLI-SSKHVSKDMER 826 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F++E +I++SL HPNVV F P ++ V EFM GSL L Sbjct: 827 -----SFFEEVKIMTSLRHPNVVLFMAASTKSP--NMCIVMEFMSLGSLYDLL 872
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 64.3 bits (155), Expect = 3e-10 Identities = 50/136 (36%), Positives = 69/136 (50%), Gaps = 13/136 (9%) Frame = +1 Query: 232 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 375 QH S+G+ +S P+ A L G I DL +KELG+G +G V +GKW Sbjct: 361 QHNSAGLISRLKYPVSRHQKSAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 419 Query: 376 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSL 552 RG +VAIK I+ +G SE E F EA+++ +L H +V YGV + Sbjct: 420 RGQYNVAIKMIR----EGSMSEDE-----FIDEAKVMMNLSHEKLVQLYGVCT--KQRPI 468 Query: 553 ATVTEFMVNGSLKQFL 600 +TE+M NG L FL Sbjct: 469 FIITEYMANGCLLNFL 484
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 63.9 bits (154), Expect = 4e-10 Identities = 45/134 (33%), Positives = 71/134 (52%), Gaps = 14/134 (10%) Frame = +1 Query: 241 SSGIESTPAEAEALSKGLQTIKN-------DDLE------EIKE-LGSGTYGSVFHGKWR 378 S+ IE+ P A +S+ + N DD++ IKE +G+G++G+V +W Sbjct: 512 SNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH 571 Query: 379 GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 558 G DVA+K + F +ER + +F +E I+ L HPN+V F G V P +L+ Sbjct: 572 GSDVAVKILMEQDFH---AER---VNEFLREVAIMKRLRHPNIVLFMGAVTQPP--NLSI 623 Query: 559 VTEFMVNGSLKQFL 600 VTE++ GSL + L Sbjct: 624 VTEYLSRGSLYRLL 637
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/101 (34%), Positives = 57/101 (56%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +++E + E+G G +GSV KW R +VA K +++S +ERE+ + EA+ Sbjct: 215 INRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSS-----KAEREKFVL----EAK 265 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 I+ L H +V GV + D + + E+M NGSLK++L Sbjct: 266 IMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYL 306
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 60.8 bits (146), Expect = 3e-09 Identities = 39/113 (34%), Positives = 55/113 (48%), Gaps = 1/113 (0%) Frame = +1 Query: 265 AEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSER 441 A+ +K + I + L+ IK LG+G +G V+ G W G VA+K +K Sbjct: 253 ADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPE---- 308 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTE+M GSL FL Sbjct: 309 -----SFLEEAQIMKKLRHDKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 353
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 59.7 bits (143), Expect = 7e-09 Identities = 39/107 (36%), Positives = 53/107 (49%), Gaps = 1/107 (0%) Frame = +1 Query: 283 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIAD 459 +K + I + L+ IK LG+G +G V+ G W G VAIK +K Sbjct: 259 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---------S 309 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTE+M GSL FL Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 353
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 59.3 bits (142), Expect = 9e-09 Identities = 41/131 (31%), Positives = 62/131 (47%), Gaps = 1/131 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + S+ + DL+ ++ +G G +G V G +RG Sbjct: 159 DADGLCSRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSG-LYIVTE 267 Query: 568 FMVNGSLKQFL 600 +M GSL +L Sbjct: 268 YMAKGSLVDYL 278
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 59.3 bits (142), Expect = 9e-09 Identities = 39/107 (36%), Positives = 53/107 (49%), Gaps = 1/107 (0%) Frame = +1 Query: 283 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIAD 459 +K + I + L+ IK LG+G +G V+ G W G VAIK +K Sbjct: 259 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---------S 309 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTE+M GSL FL Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEYMNKGSLLDFL 353
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 59.3 bits (142), Expect = 9e-09 Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 1/113 (0%) Frame = +1 Query: 265 AEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSER 441 A+ +K + I + L+ +++LG+G +G V+ G W G VA+K +K Sbjct: 252 ADLSVKTKDVWEIPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPEA--- 308 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 309 ------FLEEAQIMKRLRHDKLVQLYAVVSEEP---IYIVTEFMSQGSLLDFL 352
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 58.2 bits (139), Expect = 2e-08 Identities = 37/110 (33%), Positives = 56/110 (50%), Gaps = 2/110 (1%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 +L IK DDL+ + G G++GSV+ KW D VA+K++ Sbjct: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------- 47 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 KEA+ILS L H N++ FYGV+ + P+ + VTE+ GSL ++ Sbjct: 48 -LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGI--VTEYASLGSLYDYI 94
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 58.2 bits (139), Expect = 2e-08 Identities = 39/112 (34%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + LSK I D L +LG G +G V+ G W G VAIK +K Sbjct: 249 QTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 304 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 305 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 348
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 58.2 bits (139), Expect = 2e-08 Identities = 37/110 (33%), Positives = 56/110 (50%), Gaps = 2/110 (1%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 +L IK DDL+ + G G++GSV+ KW D VA+K++ Sbjct: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------- 47 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 KEA+ILS L H N++ FYGV+ + P+ + VTE+ GSL ++ Sbjct: 48 -LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGI--VTEYASLGSLYDYI 94
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 57.8 bits (138), Expect = 3e-08 Identities = 33/101 (32%), Positives = 53/101 (52%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I + ++ +K LGSG +G V+ G W VA+K +K D DF +EAQ Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN---------DFLREAQ 279 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 I+ +L HP ++ Y V + + +TE M +GSL+++L Sbjct: 280 IMKNLRHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYL 318
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 57.4 bits (137), Expect = 4e-08 Identities = 39/116 (33%), Positives = 55/116 (47%), Gaps = 1/116 (0%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRP 432 S + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 SVKPQTQGLAKDAWEIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTM---- 305 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EAQI+ L H +V Y VV + P + VTE+M+ GSL FL Sbjct: 306 -----MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEYMIKGSLLDFL 353
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 57.0 bits (136), Expect = 5e-08 Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 1/107 (0%) Frame = +1 Query: 283 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPSERERLIAD 459 +K + I D + I++LG+G +G V+ G W VA+K +KA A Sbjct: 84 TKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQP---------AA 134 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F EAQI+ L HP ++ Y V G + +TE M GSL +L Sbjct: 135 FLAEAQIMKKLRHPKLIQLYAVCTQGE--PVYIITELMSKGSLLDYL 179
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 629
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 629
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 629
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 629
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 57.0 bits (136), Expect = 5e-08 Identities = 39/112 (34%), Positives = 53/112 (47%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 251 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM-------- 302 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 303 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMTKGSLLDFL 350
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 629
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 57.0 bits (136), Expect = 5e-08 Identities = 39/112 (34%), Positives = 53/112 (47%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 309 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 310 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMTKGSLLDFL 357
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 57.0 bits (136), Expect = 5e-08 Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 7/109 (6%) Frame = +1 Query: 295 QTIKNDDLEEIKELGSGTYGSVFHG-------KWRGCDVAIKRIKASCFDGRPSERERLI 453 +T++ + ++ +G G +G VF G K VA+K +K SC D L Sbjct: 497 KTVRLQTILLMRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDS-------LK 549 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L+++ H N+V+FYGV + + + EFM NG L ++L Sbjct: 550 RDFEREAEMLATIEHANIVTFYGVCTESDQWMM--IFEFMENGDLNKYL 596
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 56.6 bits (135), Expect = 6e-08 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKVKMLVAVKALK 575 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 629
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 56.6 bits (135), Expect = 6e-08 Identities = 42/119 (35%), Positives = 59/119 (49%), Gaps = 1/119 (0%) Frame = +1 Query: 247 GIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFD 423 G + P A L G I +L ++E+GSG +G V G W D VAIK I+ + Sbjct: 341 GRQKAPVTA-GLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIR----E 395 Query: 424 GRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 G SE DF +EA+++ L HP +V YGV + + V EFM +G L +L Sbjct: 396 GAMSEE-----DFIEEAEVMMKLSHPKLVQLYGVCLE--QAPICLVFEFMEHGCLSDYL 447
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 56.6 bits (135), Expect = 6e-08 Identities = 38/116 (32%), Positives = 57/116 (49%), Gaps = 13/116 (11%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 456 +Q IK D+ +ELG G +G VF A C++ P+ + L+A Sbjct: 532 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTNDKMLVAVKALK 577 Query: 457 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV DG L V E+M +G L +FL Sbjct: 578 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHGDLNKFL 631
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 56.6 bits (135), Expect = 6e-08 Identities = 41/102 (40%), Positives = 55/102 (53%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L +KE+GSG +G V G+WR VAIK I +G SE DF +EA+ Sbjct: 266 IDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAIN----EGSMSEE-----DFIEEAK 316 Query: 478 ILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H +V YGV ++ P L VTEFM NG L +L Sbjct: 317 VMMKLSHSRLVQLYGVCIQQKP---LYIVTEFMENGCLLDYL 355
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 56.6 bits (135), Expect = 6e-08 Identities = 42/102 (41%), Positives = 55/102 (53%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L IKE+GSG +G V G+WR VAIK I +G SE DF +EA+ Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN----EGSMSEE-----DFIEEAK 316 Query: 478 ILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H +V YGV ++ P L VTEFM NG L +L Sbjct: 317 VMMKLSHSKLVQLYGVCIQRKP---LYIVTEFMENGCLLNYL 355
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 56.2 bits (134), Expect = 8e-08 Identities = 33/101 (32%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L++I++LG G +G V G G VA+K +K P RE ++ W+E Sbjct: 875 LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLK-------PENREEQSSNLWREIH 927 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL L+H N+V + G+ + S+ + EF+ GSLK++L Sbjct: 928 ILRELYHENIVKYKGIWHEEGGRSIKLIMEFLPAGSLKEYL 968
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 56.2 bits (134), Expect = 8e-08 Identities = 31/92 (33%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 ++LG G +G V+ G W G VA+K +K + + DF +EAQ++ +HHPN Sbjct: 70 RKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTME---------VKDFVQEAQVMKKIHHPN 120 Query: 505 VVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ Y V G + VTE M GS+ ++L Sbjct: 121 LLQLYAVCTIGE--PIYIVTELMKYGSMLEYL 150
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 56.2 bits (134), Expect = 8e-08 Identities = 39/112 (34%), Positives = 53/112 (47%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 309 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 310 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGSLLDFL 357
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 56.2 bits (134), Expect = 8e-08 Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 2/92 (2%) Frame = +1 Query: 331 ELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 +LG G YG V+ G W+ C +A+K +K D P + +F EA I+ LHH N Sbjct: 316 KLGGGQYGDVYEGYWKRHDCTIAVKALKE---DAMP------LHEFLAEAAIMKDLHHKN 366 Query: 505 VVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +V GV + +TEFM NG+L ++L Sbjct: 367 LVRLLGVCTH--EAPFYIITEFMCNGNLLEYL 396
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 56.2 bits (134), Expect = 8e-08 Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 1/131 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 568 FMVNGSLKQFL 600 +M GSL +L Sbjct: 268 YMAKGSLVDYL 278
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 56.2 bits (134), Expect = 8e-08 Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 1/131 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 568 FMVNGSLKQFL 600 +M GSL +L Sbjct: 268 YMAKGSLVDYL 278
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 56.2 bits (134), Expect = 8e-08 Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 1/131 (0%) Frame = +1 Query: 211 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 568 FMVNGSLKQFL 600 +M GSL +L Sbjct: 268 YMAKGSLVDYL 278
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 56.2 bits (134), Expect = 8e-08 Identities = 39/112 (34%), Positives = 53/112 (47%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 256 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM-------- 307 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 308 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGSLLDFL 355
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 56.2 bits (134), Expect = 8e-08 Identities = 39/112 (34%), Positives = 53/112 (47%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 260 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 311 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 312 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGSLLDFL 359
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/101 (32%), Positives = 52/101 (51%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L++I++LG G +G V G G VA+K +K P RE + W+E Sbjct: 872 LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLK-------PENREEQSNNLWREIH 924 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL L+H N+V + G+ + S+ + EF+ GSLK++L Sbjct: 925 ILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYL 965
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 55.8 bits (133), Expect = 1e-07 Identities = 39/108 (36%), Positives = 56/108 (51%), Gaps = 1/108 (0%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 456 L G I+ +L ++E+GSG +G V G W D VAIK I+ +G SE Sbjct: 356 LRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQ----EGAMSEE----- 406 Query: 457 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA+++ L HP +V YGV + + V EFM +G L +L Sbjct: 407 DFIEEAEVMMKLSHPKLVQLYGVCLE--QAPICLVFEFMEHGCLSDYL 452
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 55.5 bits (132), Expect = 1e-07 Identities = 34/96 (35%), Positives = 52/96 (54%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++E + +GSG++G V+ G+ R VAIKR +A+ + + + F +E IL L Sbjct: 460 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQL 514 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +HP VV F G D P A VT+++ GSL L Sbjct: 515 NHPCVVQFVGACLDDP-SQFAIVTQYISGGSLFSLL 549
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 349
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 349
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/108 (34%), Positives = 53/108 (49%), Gaps = 1/108 (0%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 456 L+K I + + LG+G +G V+ G W G VA+K +K + S Sbjct: 274 LAKDAWEISRSSITLQRRLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKAS------- 326 Query: 457 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +EAQI+ L H +V Y VV P+ + VTEFM +GSL +FL Sbjct: 327 --LEEAQIMKLLRHDKLVQLYAVV---PEEPIYIVTEFMCHGSLLEFL 369
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 55.5 bits (132), Expect = 1e-07 Identities = 40/101 (39%), Positives = 52/101 (51%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L ++ELGSG +G V GKWR VAIK I+ +G E DF +EA+ Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR----EGAMCEE-----DFIEEAK 415 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L HP +V YGV + VTEFM G L FL Sbjct: 416 VMMKLTHPKLVQLYGVCTQ--QKPIYIVTEFMERGCLLNFL 454
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 349
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 349
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 55.5 bits (132), Expect = 1e-07 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 1/116 (0%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRP 432 S + L+K + D L K+LG G + V+ G W G VAIK +K Sbjct: 247 SCTPQTSGLAKDAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPE- 305 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 --------SFLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 350
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 349
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 55.5 bits (132), Expect = 1e-07 Identities = 40/101 (39%), Positives = 52/101 (51%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +L ++ELGSG +G V GKWR VAIK I+ +G E DF +EA+ Sbjct: 364 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR----EGAMCEE-----DFIEEAK 414 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L HP +V YGV + VTEFM G L FL Sbjct: 415 VMMKLTHPKLVQLYGVCTQ--QKPIYIVTEFMERGCLLNFL 453
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 55.5 bits (132), Expect = 1e-07 Identities = 34/96 (35%), Positives = 52/96 (54%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++E + +GSG++G V+ G+ R VAIKR +A+ + + + F +E IL L Sbjct: 461 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQL 515 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +HP VV F G D P A VT+++ GSL L Sbjct: 516 NHPCVVQFVGACLDDP-SQFAIVTQYISGGSLFSLL 550
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 253 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 308 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 309 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFL 352
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + LS+ I D L +LG G +G V+ G W G VAIK +K Sbjct: 249 QTQGLSRDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 304 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE++ GSL FL Sbjct: 305 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYISKGSLLDFL 348
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 55.1 bits (131), Expect = 2e-07 Identities = 38/112 (33%), Positives = 51/112 (45%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + ++K I + L LG G +G V+ G W G VAIK +K Sbjct: 261 QTQGIAKDAWEIPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEA---- 316 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 317 -----FLEEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMGKGSLLDFL 360
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 55.1 bits (131), Expect = 2e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 313 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 314 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMNKGSLLDFL 357
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 55.1 bits (131), Expect = 2e-07 Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 1/108 (0%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 456 L+K I + + LG+G +G V+ G W G VA+K +K + Sbjct: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKA-------- 302 Query: 457 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTEFM +GSL FL Sbjct: 303 -FLEEAQVMKLLRHDKLVQLYAVVSEEP---IYIVTEFMCHGSLLDFL 346
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 55.1 bits (131), Expect = 2e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVRLYAVVSEEP---IYIVTEYMSKGSLLDFL 349
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 55.1 bits (131), Expect = 2e-07 Identities = 37/112 (33%), Positives = 52/112 (46%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 253 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 308 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + VTE+M GSL FL Sbjct: 309 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMNKGSLLDFL 352
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 54.7 bits (130), Expect = 2e-07 Identities = 33/101 (32%), Positives = 52/101 (51%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ I++LG G +G V G G VA+K +K P IAD KE + Sbjct: 874 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-------PESGGNHIADLKKEIE 926 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL +L+H N+V + G+ + + + EF+ +GSLK++L Sbjct: 927 ILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYL 967
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 53.9 bits (128), Expect = 4e-07 Identities = 39/96 (40%), Positives = 51/96 (53%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +GSG G V +G+ R VAIK +KA +ER+R DF +EA I+ Sbjct: 6 KIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGY-----TERQR--QDFLREAAIMGQF 58 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV G + VTE+M NGSL FL Sbjct: 59 DHPNIIRLEGVVTRGRLAMI--VTEYMENGSLDAFL 92
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 53.9 bits (128), Expect = 4e-07 Identities = 32/100 (32%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 L+ I++LG G +G V ++ G VA+K +K P IAD KE +I Sbjct: 864 LKRIRDLGEGHFGKVELCRYDPEDNTGEQVAVKSLK-------PESGGNHIADLKKEIEI 916 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L +L+H N+V + G+ + + + EF+ +GSLK++L Sbjct: 917 LRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYL 956
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 53.5 bits (127), Expect = 5e-07 Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR-GCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I +++ +++LG G +G VF+GKWR DVA+K ++ E A F +EA Sbjct: 279 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR---------EGTMSTAAFLQEAA 329 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 I+ H +V+ Y V + + V E+M GSL FL Sbjct: 330 IMKKFRHNRLVALYAVC--SQEEPIYIVQEYMSKGSLLDFL 368
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 53.5 bits (127), Expect = 5e-07 Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +GSG G V +G+ R VAIK +KA +ER+R DF EA I+ Sbjct: 639 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-----TERQR--RDFLSEASIMGQF 691 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV G + VTE+M NGSL FL Sbjct: 692 DHPNIIRLEGVVTRGRLAMI--VTEYMENGSLDTFL 725
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 53.5 bits (127), Expect = 5e-07 Identities = 39/124 (31%), Positives = 61/124 (49%), Gaps = 3/124 (2%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKE---LGSGTYGSVFHGKWRGCDVAIKRIK 408 K + A+ L GL + + L EI+ +GSG++G V+ G+ R VAIKR + Sbjct: 433 KIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYR 492 Query: 409 ASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSL 588 A+ + + + F +E IL L+HP V+ F G + P A VT+++ GSL Sbjct: 493 ANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGSL 546 Query: 589 KQFL 600 L Sbjct: 547 FSLL 550
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + V E+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVIEYMSKGSLLDFL 349
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 53.5 bits (127), Expect = 5e-07 Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I L+ +++LGSG +G V+ G W VAIK +K+ D + DF EAQ Sbjct: 243 IDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPK---------DFLAEAQ 293 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 I+ L H ++ Y V + + +TE M +GSL ++L Sbjct: 294 IMKKLRHTKLIQLYAVCT--VEEPIYIITELMKHGSLLEYL 332
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 53.5 bits (127), Expect = 5e-07 Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 622 IEEV--IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY-----SEKQR--RDFLSEASI 672 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM NG+L FL Sbjct: 673 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFL 710
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 53.5 bits (127), Expect = 5e-07 Identities = 39/124 (31%), Positives = 61/124 (49%), Gaps = 3/124 (2%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKE---LGSGTYGSVFHGKWRGCDVAIKRIK 408 K + A+ L GL + + L EI+ +GSG++G V+ G+ R VAIKR + Sbjct: 535 KIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYR 594 Query: 409 ASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSL 588 A+ + + + F +E IL L+HP V+ F G + P A VT+++ GSL Sbjct: 595 ANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGSL 648 Query: 589 KQFL 600 L Sbjct: 649 FSLL 652
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 53.5 bits (127), Expect = 5e-07 Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 539 IEEV--IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY-----SEKQR--RDFLSEASI 589 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM NG+L FL Sbjct: 590 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFL 627
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 53.1 bits (126), Expect = 7e-07 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 287 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ + HPN+V GV P +TEFM G+L +L Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYL 327
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 53.1 bits (126), Expect = 7e-07 Identities = 37/110 (33%), Positives = 59/110 (53%), Gaps = 7/110 (6%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 529 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 582 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV +G L V E+M +G L +FL Sbjct: 583 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHGDLNKFL 628
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 53.1 bits (126), Expect = 7e-07 Identities = 37/110 (33%), Positives = 59/110 (53%), Gaps = 7/110 (6%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 529 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 582 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV +G L V E+M +G L +FL Sbjct: 583 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHGDLNKFL 628
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 53.1 bits (126), Expect = 7e-07 Identities = 37/110 (33%), Positives = 59/110 (53%), Gaps = 7/110 (6%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 583 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV +G L V E+M +G L +FL Sbjct: 584 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHGDLNKFL 629
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 53.1 bits (126), Expect = 7e-07 Identities = 33/92 (35%), Positives = 46/92 (50%), Gaps = 2/92 (2%) Frame = +1 Query: 331 ELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 504 +LG G YG V+ W+ G VA+K +K E + DF +EA I+ + HPN Sbjct: 376 KLGGGQYGEVYEAVWKRYGNTVAVKTLK---------EDTMALKDFLEEAAIMKEMKHPN 426 Query: 505 VVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +V GV P +TEFM +G+L FL Sbjct: 427 LVQLIGVCTREP--PFYIITEFMSHGNLLDFL 456
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 53.1 bits (126), Expect = 7e-07 Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +GSG G V +G+ R VAIK +KA +ER+R DF EA I+ Sbjct: 638 KIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGY-----TERQR--QDFLSEAAIMGQF 690 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV G + VTE+M NGSL FL Sbjct: 691 DHPNIIRLEGVVTRGRLAMI--VTEYMENGSLDAFL 724
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 53.1 bits (126), Expect = 7e-07 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 123 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 173 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ + HPN+V GV P +TEFM G+L +L Sbjct: 174 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYL 213
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 53.1 bits (126), Expect = 7e-07 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + V E+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHKKLVQLYAVVSEEP---IYIVIEYMSKGSLLDFL 349
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 53.1 bits (126), Expect = 7e-07 Identities = 37/116 (31%), Positives = 54/116 (46%), Gaps = 1/116 (0%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR-GCDVAIKRIKASCFDGRP 432 +T + L+K I + + + LG+G +G V+ G W VA+K +K + Sbjct: 231 TTKPQTLGLAKDAWEIDRNSIALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKA 290 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQI+ L H +V Y VV + P + VTEFM GSL FL Sbjct: 291 ---------FLEEAQIMKLLRHDKLVQLYAVVSEEP---IYIVTEFMCYGSLLDFL 334
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 53.1 bits (126), Expect = 7e-07 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 287 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ + HPN+V GV P +TEFM G+L +L Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYL 327
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 53.1 bits (126), Expect = 7e-07 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 186 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 236 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ + HPN+V GV P +TEFM G+L +L Sbjct: 237 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYL 276
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 53.1 bits (126), Expect = 7e-07 Identities = 37/110 (33%), Positives = 59/110 (53%), Gaps = 7/110 (6%) Frame = +1 Query: 292 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 450 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 526 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 579 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +EA++L++L H ++V FYGV +G L V E+M +G L +FL Sbjct: 580 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHGDLNKFL 625
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 52.4 bits (124), Expect = 1e-06 Identities = 35/100 (35%), Positives = 53/100 (53%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII----RELQV 117 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYGV DG ++ E M GSL Q L Sbjct: 118 LHECNSPYIVGFYGVFYS--DGEISICMEHMDGGSLDQVL 155
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 52.4 bits (124), Expect = 1e-06 Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I+ ++ ++ LG+G +G V+ G W G VA+K +K I +F +EA Sbjct: 235 IEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------IEEFLEEAS 285 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 I+ L HP ++ Y V + + VTE M +GSL ++L Sbjct: 286 IMKQLRHPKLIQLYAVCT--KEEPIYIVTELMKHGSLLEYL 324
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 52.4 bits (124), Expect = 1e-06 Identities = 40/126 (31%), Positives = 58/126 (46%) Frame = +1 Query: 223 SCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKR 402 S SS S EA + + I ++E + +G G +G V KWR DVAIK+ Sbjct: 5 SAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQ 64 Query: 403 IKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 582 I++ SER+ I E + LS ++HPN+V YG + + V E+ G Sbjct: 65 IESE------SERKAFIV----ELRQLSRVNHPNIVKLYGACLN----PVCLVMEYAEGG 110 Query: 583 SLKQFL 600 SL L Sbjct: 111 SLYNVL 116
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 52.4 bits (124), Expect = 1e-06 Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM NG+L FL Sbjct: 672 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFL 709
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 52.4 bits (124), Expect = 1e-06 Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM NG+L FL Sbjct: 672 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFL 709
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 52.4 bits (124), Expect = 1e-06 Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM NG+L FL Sbjct: 672 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFL 709
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 52.0 bits (123), Expect = 1e-06 Identities = 41/128 (32%), Positives = 55/128 (42%), Gaps = 1/128 (0%) Frame = +1 Query: 220 GSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAI 396 G C +TP + L+K + D L ++LG G + V+ G W G VAI Sbjct: 236 GLCFNLTVIATNNTP-QTVGLAKDAWEVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAI 294 Query: 397 KRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMV 576 K +K F +EAQI+ L H +V Y VV P + VTE+M Sbjct: 295 KTLKPGTMSPE---------SFLEEAQIMKKLKHDKLVQLYAVVSRRP---IYIVTEYMS 342 Query: 577 NGSLKQFL 600 GSL FL Sbjct: 343 KGSLLIFL 350
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 51.6 bits (122), Expect = 2e-06 Identities = 35/112 (31%), Positives = 51/112 (45%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 247 QTQGLAKDAWEIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 302 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y +V + P + V E+M GSL FL Sbjct: 303 -----FLQEAQVMKKLRHEKLVQLYAMVSEEP---IYIVIEYMSKGSLLDFL 346
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/167 (26%), Positives = 75/167 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +E Q+L + P +V FYG DG ++ E M GSL Q L Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 154
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/167 (26%), Positives = 75/167 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +E Q+L + P +V FYG DG ++ E M GSL Q L Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 154
>MP2K1_PANTR (Q9XT09) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/167 (26%), Positives = 75/167 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +E Q+L + P +V FYG DG ++ E M GSL Q L Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 154
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/167 (26%), Positives = 75/167 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +E Q+L + P +V FYG DG ++ E M GSL Q L Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 154
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/167 (26%), Positives = 75/167 (44%) Frame = +1 Query: 100 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +E Q+L + P +V FYG DG ++ E M GSL Q L Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 154
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 51.2 bits (121), Expect = 3e-06 Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 I+ ++ ++ LG+G +G V+ G W G VA+K +K + +F +EA Sbjct: 235 IEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------VEEFLQEAS 285 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 I+ L HP ++ Y V + + VTE M GSL ++L Sbjct: 286 IMKRLRHPKLIQLYAVCT--KEEPIYIVTELMKYGSLLEYL 324
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 51.2 bits (121), Expect = 3e-06 Identities = 30/97 (30%), Positives = 48/97 (49%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 +D++ I+++G G + V+ G W+G VAIK++K + E+ F +E Q L Sbjct: 106 NDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLKII------GDEEQFKERFIREVQNLKK 159 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +H N+V F G +TE+M GSL L Sbjct: 160 GNHQNIVMFIGACYK----PACIITEYMAGGSLYNIL 192
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 51.2 bits (121), Expect = 3e-06 Identities = 39/100 (39%), Positives = 51/100 (51%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +GSG +G V G+ R VAIK +K+ G E+ R +F EA I Sbjct: 639 IEEV--IGSGEFGEVCFGRLKHPGKREYTVAIKTLKS----GYTDEQRR---EFLSEASI 689 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPNV+ GVV + VTEFM NGSL FL Sbjct: 690 MGQFEHPNVIHLEGVVT--KSRPVMIVTEFMENGSLDSFL 727
>ACK1_HUMAN (Q07912) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine| kinase non-receptor protein 2) Length = 1036 Score = 51.2 bits (121), Expect = 3e-06 Identities = 36/127 (28%), Positives = 51/127 (40%) Frame = +1 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 P H K+S PA L I DL +++LG G++G V G+W Sbjct: 90 PPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPS 149 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 + C + + DF +E + SL H N++ YGVV P + VTE Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP---MKMVTE 206 Query: 568 FMVNGSL 588 GSL Sbjct: 207 LAPLGSL 213
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 50.8 bits (120), Expect = 3e-06 Identities = 32/101 (31%), Positives = 49/101 (48%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 + + L+ ++ LG+G +G V+ G + G VA+K +K F EA Sbjct: 239 VPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA---------FLAEAN 289 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L HP +V Y VV P + +TE+M NGSL FL Sbjct: 290 LMKQLQHPRLVRLYAVVTQEP---IYIITEYMENGSLVDFL 327
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 50.8 bits (120), Expect = 3e-06 Identities = 36/107 (33%), Positives = 54/107 (50%), Gaps = 7/107 (6%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCD-------VAIKRIKASCFDGRPSERERLIAD 459 IK D+ ELG G +G VF + VA+K +K + + R D Sbjct: 508 IKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQ--------D 559 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EA++L+ L H ++V F+GV +G G L V E+M +G L +FL Sbjct: 560 FHREAELLTMLQHQHIVRFFGVCTEG--GPLLMVFEYMRHGDLNRFL 604
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 50.8 bits (120), Expect = 3e-06 Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 1/112 (0%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 444 + + L+K I + L +LG G +G V+ G W VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEA---- 305 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EAQ++ L H +V Y VV + P + V E+M GSL FL Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVIEYMSKGSLLDFL 349
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 50.8 bits (120), Expect = 3e-06 Identities = 40/120 (33%), Positives = 59/120 (49%) Frame = +1 Query: 241 SSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCF 420 SS E A ++ L+ K ++EE+ +G G +G V KWR DVAIK+I++ Sbjct: 13 SSAGEMIEAPSQVLNFEEIDYKEIEVEEV--VGRGAFGVVCKAKWRAKDVAIKQIESE-- 68 Query: 421 DGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 SER+ I E + LS ++HPN+V YG + + V E+ GSL L Sbjct: 69 ----SERKAFIV----ELRQLSRVNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVL 116
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 50.4 bits (119), Expect = 4e-06 Identities = 33/100 (33%), Positives = 52/100 (52%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E++ ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 62 LKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMAR-KLIHLEIKPAIRNQII----RELQV 116 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYG DG ++ E M GSL Q L Sbjct: 117 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 154
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/100 (34%), Positives = 51/100 (51%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + R + + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKARHRPSGLIMAR-KLIHLEIKPAVRNQII----RELQV 121 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYG DG ++ E M GSL Q L Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 159
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/100 (34%), Positives = 52/100 (52%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 56 LKDDDFEKISELGAGNGGVVFKVSHKPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 110 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYG DG ++ E M GSL Q L Sbjct: 111 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 148
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 50.1 bits (118), Expect = 6e-06 Identities = 40/106 (37%), Positives = 54/106 (50%), Gaps = 6/106 (5%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFW 465 + N +E + +G+G +G V G+ R VAIK +KA SE +R DF Sbjct: 623 VSNIRIERV--IGAGEFGEVCSGRLRLPSKREIQVAIKSLKAGY-----SEHQR--RDFL 673 Query: 466 KEAQILSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGSLKQFL 600 EA I+ HPN++ GVV R P + VTE+M NGSL FL Sbjct: 674 SEASIMGQFDHPNIIRLEGVVTRCKP---VMIVTEYMENGSLDTFL 716
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 50.1 bits (118), Expect = 6e-06 Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 3/120 (2%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCF 420 +ES E SKG + DL ++ + SG + ++ G ++ VA+K ++ Sbjct: 61 LESENVETWEASKGEREEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTH 120 Query: 421 DGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + R +L F E +LS L HPN+V F + P +TE+M G+L+ +L Sbjct: 121 --KEETRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKPP--VYCIITEYMSQGNLRMYL 176
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 50.1 bits (118), Expect = 6e-06 Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++++ LG+GTY +V+ G K G VA+K +K +G PS R E ++ L Sbjct: 10 KQLERLGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIR-------EISLMKEL 62 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 H N+V Y V+ + L V EFM N LK+F+ Sbjct: 63 KHENIVRLYDVIH--TENKLTLVFEFMDN-DLKKFM 95
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 49.7 bits (117), Expect = 7e-06 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 333 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ + HPN+V GV P VTE+M G+L +L Sbjct: 334 AVMKEIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYL 373
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 49.7 bits (117), Expect = 7e-06 Identities = 32/100 (32%), Positives = 52/100 (52%), Gaps = 2/100 (2%) Frame = +1 Query: 307 NDDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 + +++++LG+GTY +V+ G K G VA+K +K +G PS R E + Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-------EISL 56 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + L H N+V Y V+ + L V EFM N LK+++ Sbjct: 57 MKELKHENIVRLYDVIH--TENKLTLVFEFMDN-DLKKYM 93
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 49.7 bits (117), Expect = 7e-06 Identities = 38/101 (37%), Positives = 54/101 (53%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V GK + VAIK +KA +E++R DF EA I Sbjct: 611 IEEV--IGAGEFGEVCRGKLKQAGRREQFVAIKTLKAGY-----TEQQR--RDFLGEASI 661 Query: 481 LSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV R P + +TEFM NG+L FL Sbjct: 662 MGQFDHPNIIRLEGVVTRSRP---VMILTEFMENGALDSFL 699
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 49.7 bits (117), Expect = 7e-06 Identities = 34/100 (34%), Positives = 50/100 (50%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + R + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKARHRPSGFIMAR-KLIHLEIKPAVRNQII----RELQV 121 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYG DG ++ E M GSL Q L Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 159
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 49.3 bits (116), Expect = 1e-05 Identities = 35/96 (36%), Positives = 49/96 (51%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G+G +G V G+ + VAIK +KA +E++R DF EA I+ Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGY-----TEKQR--RDFLGEASIMGQF 677 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + VTE+M NGSL FL Sbjct: 678 DHPNIIRLEGVVTKSK--PVMIVTEYMENGSLDSFL 711
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 49.3 bits (116), Expect = 1e-05 Identities = 33/99 (33%), Positives = 55/99 (55%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 LHHPN+V V+ D L + EF+ + LK++L Sbjct: 56 KELHHPNIVCLQDVLMQ--DARLYLIFEFL-SMDLKKYL 91
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 48.9 bits (115), Expect = 1e-05 Identities = 42/162 (25%), Positives = 73/162 (45%), Gaps = 15/162 (9%) Frame = +1 Query: 160 DKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKN---------- 309 D G+ D G P S + S + S E ++L+ + +KN Sbjct: 242 DAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYYW 301 Query: 310 ----DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 +++ +K +G+G++G+VF G+W G DVA+K +K + +P+ + F E Q Sbjct: 302 EVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QPTAEQ--AQAFKNEMQ 354 Query: 478 ILSSLHHPNVVSFYG-VVRDGPDGSLATVTEFMVNGSLKQFL 600 +L H N++ F G + R G A +T++ SL L Sbjct: 355 VLRKTRHVNILLFMGFMTRPG----FAIITQWCEGSSLYHHL 392
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 48.9 bits (115), Expect = 1e-05 Identities = 35/100 (35%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V G+ + VAIK +K G +ER+R +F EA I Sbjct: 617 IEEV--IGAGEFGEVCRGRLKAPGKKESCVAIKTLK-----GGYTERQR--REFLSEASI 667 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + + +TEFM NG+L FL Sbjct: 668 MGQFEHPNIIRLEGVVTNSV--PVMILTEFMENGALDSFL 705
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 48.9 bits (115), Expect = 1e-05 Identities = 35/100 (35%), Positives = 53/100 (53%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V G+ + VAIK +K G +ER+R +F EA I Sbjct: 617 IEEV--IGAGEFGEVCRGRLKAPGKKESCVAIKTLK-----GGYTERQR--REFLSEASI 667 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + + +TEFM NG+L FL Sbjct: 668 MGQFEHPNIIRLEGVVTNSM--PVMILTEFMENGALDSFL 705
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 48.9 bits (115), Expect = 1e-05 Identities = 38/101 (37%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V G+ + VAIK +KA +E +R DF EA I Sbjct: 189 IEEV--IGAGEFGEVCRGRLKQAGRKETTVAIKTLKAGY-----TEHQR--RDFLSEASI 239 Query: 481 LSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGSLKQFL 600 + HPNV+ GV+ R P + VTEFM NG+L FL Sbjct: 240 MGQFDHPNVIHLEGVLTRSCP---VLIVTEFMENGALDSFL 277
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 1/115 (0%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPS 435 +P + K I + ++ +K+LG+G +G V+ G + VA+K +K + Sbjct: 227 SPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSAQA- 285 Query: 436 ERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EA ++ +L H +V Y VV + + +TEFM GSL FL Sbjct: 286 --------FLEEANLMKTLQHDKLVRLYAVVTK--EEPIYIITEFMAKGSLLDFL 330
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 1/115 (0%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPS 435 +P + K I + ++ +K+LG+G +G V+ G + VA+K +K Sbjct: 227 SPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMS---- 282 Query: 436 ERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F +EA ++ +L H +V Y VV + + +TEFM GSL FL Sbjct: 283 -----VQAFLEEANLMKTLQHDKLVRLYAVVTK--EEPIYIITEFMAKGSLLDFL 330
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 48.5 bits (114), Expect = 2e-05 Identities = 34/100 (34%), Positives = 51/100 (51%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + R + + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKVQHRPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 121 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYG DG ++ E M GSL Q L Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 159
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 48.5 bits (114), Expect = 2e-05 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 645 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 697 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNV+ GVV + +TEFM NGSL FL Sbjct: 698 PNVIHLEGVVT--KSSPVMIITEFMENGSLDSFL 729
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 48.5 bits (114), Expect = 2e-05 Identities = 36/100 (36%), Positives = 51/100 (51%), Gaps = 10/100 (10%) Frame = +1 Query: 331 ELGSGTYGSVFHGKWRGCD----------VAIKRIKASCFDGRPSERERLIADFWKEAQI 480 ELG G +G VF + C VA+K +K +E RL DF +EA++ Sbjct: 498 ELGEGAFGKVFLAE---CSHLLPEQEKTLVAVKALK------EVTENARL--DFQREAEL 546 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L+ L H ++V FYGV +G L V E+M +G L +FL Sbjct: 547 LTVLQHEHIVKFYGVCTEG--DPLIMVFEYMKHGDLNRFL 584
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 48.5 bits (114), Expect = 2e-05 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 628 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 680 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNV+ GVV + +TEFM NGSL FL Sbjct: 681 PNVIHLEGVVT--KSSPVMIITEFMENGSLDSFL 712
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 48.5 bits (114), Expect = 2e-05 Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 17/145 (11%) Frame = +1 Query: 217 HGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR--GCDV 390 +G + + SG++ +P + + L N D E+I+E+G G +G VF K R G Sbjct: 209 NGLGENKRKSGVKVSPDDVQRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRY 268 Query: 391 AIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFY----GVVRDGPDGSLAT 558 AIKR+K ++ +E E Q L+ L+H N+V ++ GV D P+ S++ Sbjct: 269 AIKRVK---YNTEKAEH---------EVQALAELNHVNIVQYHSCWEGVDYD-PEHSMSD 315 Query: 559 VT-----------EFMVNGSLKQFL 600 + EF G+L+Q++ Sbjct: 316 TSRYKTRCLFIQMEFCDKGTLEQWM 340
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 48.5 bits (114), Expect = 2e-05 Identities = 34/99 (34%), Positives = 55/99 (55%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ R G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+VS V+ D L + EF+ + LK++L Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 48.5 bits (114), Expect = 2e-05 Identities = 34/99 (34%), Positives = 55/99 (55%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ R G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+VS V+ D L + EF+ + LK++L Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 48.5 bits (114), Expect = 2e-05 Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 2/102 (1%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEA 474 + + +++++LG+GTY +V+ G K G VA+K +K +G PS R E Sbjct: 1 MSSSQFKQLEKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIR-------EI 53 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H N+V Y V+ + L V E+M N LK+++ Sbjct: 54 SLMKELKHDNIVRLYDVIH--TENKLTLVFEYMDN-DLKKYM 92
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 635 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 687 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNV+ GVV + +TEFM NGSL FL Sbjct: 688 PNVIHLEGVVTKST--PVMIITEFMENGSLDSFL 719
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 48.1 bits (113), Expect = 2e-05 Identities = 31/97 (31%), Positives = 50/97 (51%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 +++ E++ LGSG G+VF GK+R +VAIK++ RE+ D + L Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDI----KHLRK 210 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+++F GV P + E+ +G L + L Sbjct: 211 LKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVL 245
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 48.1 bits (113), Expect = 2e-05 Identities = 31/97 (31%), Positives = 50/97 (51%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 +++ E++ LGSG G+VF GK+R +VAIK++ RE+ D + L Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDI----KHLRK 210 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+++F GV P + E+ +G L + L Sbjct: 211 LKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVL 245
>ACK2_BOVIN (O02742) Activated CDC42 kinase 2 (EC 2.7.10.2) (ACK-2)| Length = 747 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/127 (27%), Positives = 50/127 (39%) Frame = +1 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 P H K+S A +L I DL ++LG G++G V G+W Sbjct: 90 PPHHSQSTFRKTSPTPGGSAGEGSLQSLTCLIGEKDLHLFEKLGDGSFGVVRRGEWDAPS 149 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 567 + C + + DF +E + SL H N++ YGVV P + VTE Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP---MKMVTE 206 Query: 568 FMVNGSL 588 GSL Sbjct: 207 LAPLGSL 213
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 48.1 bits (113), Expect = 2e-05 Identities = 37/107 (34%), Positives = 53/107 (49%), Gaps = 7/107 (6%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVF----HGKWRGCD---VAIKRIKASCFDGRPSERERLIAD 459 IK D+ ELG G +G VF H D VA+K +K + R D Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ--------D 556 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +EA++L+ L H ++V F+GV +G L V E+M +G L +FL Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFL 601
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 48.1 bits (113), Expect = 2e-05 Identities = 33/103 (32%), Positives = 54/103 (52%), Gaps = 3/103 (2%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGC--DVAIKRIKASCFDGRPSERERLIADFWKEA 474 + NDD+ ++ +G G +G V+ K + DVA+K +C P E++R F +E Sbjct: 1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVK----TCRMTLPDEQKR---KFLQEG 1110 Query: 475 QILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGSLKQFL 600 +IL HPN+V G+ V+ P + V E ++ GSL +L Sbjct: 1111 RILKQYDHPNIVKLIGICVQKQP---IMIVMELVLGGSLLTYL 1150
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 627 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 679 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNV+ GVV + +TEFM NGSL FL Sbjct: 680 PNVIHLEGVVTKST--PVMIITEFMENGSLDSFL 711
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 48.1 bits (113), Expect = 2e-05 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+VS V+ D L + EF+ + LK++L Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 48.1 bits (113), Expect = 2e-05 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+VS V+ D L + EF+ + LK++L Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 48.1 bits (113), Expect = 2e-05 Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 2/116 (1%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPS 435 +P + K I + ++ +K LG+G +G V+ G + VA+K +K Sbjct: 227 SPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMS---- 282 Query: 436 ERERLIADFWKEAQILSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGSLKQFL 600 + F +EA ++ +L H +V Y VV R+ P + +TE+M GSL FL Sbjct: 283 -----VQAFLEEANLMKTLQHDKLVRLYAVVTREEP---IYIITEYMAKGSLLDFL 330
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 47.8 bits (112), Expect = 3e-05 Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G+G +G V G+ + VAIK +K +E++R DF EA I+ Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-----TEKQR--RDFLGEASIMGQF 677 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + VTE+M NGSL FL Sbjct: 678 DHPNIIRLEGVVTKSKPEMI--VTEYMENGSLDSFL 711
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 47.8 bits (112), Expect = 3e-05 Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G+G +G V G+ + VAIK +K +E++R DF EA I+ Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-----TEKQR--RDFLGEASIMGQF 677 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + VTE+M NGSL FL Sbjct: 678 DHPNIIRLEGVVTKSK--PVMIVTEYMENGSLDSFL 711
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 + + L+ ++ LG+G +G V+ G + G VA+K +K F EA Sbjct: 239 VPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA---------FLAEAN 289 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H +V Y VV P + +TE+M NGSL FL Sbjct: 290 LMKQLQHQRLVRLYAVVTQEP---IYIITEYMENGSLVDFL 327
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 47.8 bits (112), Expect = 3e-05 Identities = 41/162 (25%), Positives = 73/162 (45%), Gaps = 15/162 (9%) Frame = +1 Query: 160 DKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKN---------- 309 D G+ D G P S + S + + E ++L+ + +KN Sbjct: 242 DAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYW 301 Query: 310 ----DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 +++ +K +G+G++G+VF G+W G DVA+K +K + +P+ + F E Q Sbjct: 302 EVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QPTAEQ--AQAFKNEMQ 354 Query: 478 ILSSLHHPNVVSFYG-VVRDGPDGSLATVTEFMVNGSLKQFL 600 +L H N++ F G + R G A +T++ SL L Sbjct: 355 VLRKTRHVNILLFMGFMTRPG----FAIITQWCEGSSLYHHL 392
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 47.8 bits (112), Expect = 3e-05 Identities = 36/96 (37%), Positives = 50/96 (52%), Gaps = 7/96 (7%) Frame = +1 Query: 322 EIKELGSGTYGSVFHGKWRG--CDVAIKRIKASCFD-GRPSERERLIADF----WKEAQI 480 ++++LGSG YG V K + + AIK IK S FD GR ++ + I F + E + Sbjct: 58 KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFHEEIYNEISL 117 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSL 588 L SL HPN++ + V D L VTEF G L Sbjct: 118 LKSLDHPNIIKLFDVFEDKKYFYL--VTEFYEGGEL 151
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL SL H N+V + GV +L + E++ GSL+ +L Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYL 941 Score = 36.6 bits (83), Expect = 0.064 Identities = 31/101 (30%), Positives = 49/101 (48%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQ 477 I+N+DL + LG GT+ +F G R + K + R ++ F++ A Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAAS 599 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++S L H ++V YGV G + L V EF+ GSL +L Sbjct: 600 MMSQLSHKHLVLNYGVCVCGEENIL--VQEFVKFGSLDTYL 638
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 47.8 bits (112), Expect = 3e-05 Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 5/120 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKND--DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 +TP A LS+ L D + + LGSG +GSV+ + G VAIK++ R Sbjct: 39 ATPPRAPRLSRRLAWCFIDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLR 98 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDG--SLAT-VTEFMVNGSLKQFL 600 S+R +FW E I + LHH N++ P+G SL T + EF N +L Q + Sbjct: 99 ASQR-----NFWAELNI-ARLHHDNIIRVVAASTRTPEGSNSLGTIIMEFGGNVTLHQVI 152
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 2/96 (2%) Frame = +1 Query: 319 EEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 ++++++G+GTY +V+ G K G VA+K +K +G PS R E ++ L Sbjct: 8 KQLEKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-------EISLMKEL 60 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 H N+V + V+ + L V EFM N LK+F+ Sbjct: 61 KHDNIVRLFDVIH--TENKLTLVFEFMDN-DLKKFM 93
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 47.8 bits (112), Expect = 3e-05 Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 2/93 (2%) Frame = +1 Query: 328 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 501 K LG G +G V+ + G ++A+K+++ FD E + + E Q+L +L H Sbjct: 360 KLLGQGAFGRVYLCYDVDTGRELAVKQVQ---FDPDSPETSKEVNALECEIQLLKNLLHE 416 Query: 502 NVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +V +YG +RD + +L+ E+M GS+K L Sbjct: 417 RIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQL 449
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 1/97 (1%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 +++ +K +G+G++G+VF G+W G DVA+K +K S +P+ + F E Q+L Sbjct: 309 EVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVS----QPTAEQ--AQAFKNEMQVLRKT 361 Query: 493 HHPNVVSFYG-VVRDGPDGSLATVTEFMVNGSLKQFL 600 H N++ F G + R G A +T++ SL L Sbjct: 362 RHVNILLFMGFMTRPG----FAIITQWCEGSSLYHHL 394
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL SL H N+V + GV +L + E++ GSL+ +L Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYL 941 Score = 36.2 bits (82), Expect = 0.084 Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVF---------HGKWRGCDVAIKRIKASCFDGRPSERERLI 453 I+N+DL + LG GT+ +F +G+ +V +K + + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F++ A ++S L H ++V YGV G + L V EF+ GSL +L Sbjct: 592 ESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL--VQEFVKFGSLDTYL 638
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL SL H N+V + GV +L + E++ GSL+ +L Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL 941 Score = 36.2 bits (82), Expect = 0.084 Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVF---------HGKWRGCDVAIKRIKASCFDGRPSERERLI 453 I+N+DL + LG GT+ +F +G+ +V +K + + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F++ A ++S L H ++V YGV G + L V EF+ GSL +L Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL--VQEFVKFGSLDTYL 638
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 47.8 bits (112), Expect = 3e-05 Identities = 38/95 (40%), Positives = 53/95 (55%), Gaps = 2/95 (2%) Frame = +1 Query: 322 EIKELGSGTYGSVFHGKWR-GCDVAIKR-IKASCFDGRPSERERLIADFWKEAQILSSLH 495 E ++G G++ VF G R G VA+KR IKAS D + S +E F E +LS L+ Sbjct: 507 EDSQVGKGSFSCVFKGILRDGTVVAVKRAIKAS--DVKKSSKE-----FHNELDLLSRLN 559 Query: 496 HPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 H ++++ G DG + L V EFM +GSL Q L Sbjct: 560 HAHLLNLLGYCEDGSERLL--VYEFMAHGSLYQHL 592
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/95 (32%), Positives = 49/95 (51%), Gaps = 2/95 (2%) Frame = +1 Query: 322 EIKEL-GSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSLH 495 E+KEL G+G +G V+ W+G +VA+K + P + A+ +EA++ + L Sbjct: 125 ELKELIGAGGFGQVYRATWQGQEVAVKAARQD-----PEQDAAAAAESVRREARLFAMLR 179 Query: 496 HPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GV P L V EF G+L + L Sbjct: 180 HPNIIELRGVCLQQP--HLCLVLEFARGGALNRAL 212
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 47.8 bits (112), Expect = 3e-05 Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G+G +G V G+ + VAIK +K +E++R DF EA I+ Sbjct: 626 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-----TEKQR--RDFLGEASIMGQF 678 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + VTE+M NGSL FL Sbjct: 679 DHPNIIRLEGVVTKSK--PVMIVTEYMENGSLDSFL 712
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 47.4 bits (111), Expect = 4e-05 Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Frame = +1 Query: 328 KELGSGTYGSV-----FHGKWRG--CDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 486 K LG G +G V FH K R VA+K +K + PSE L+++F +L Sbjct: 728 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA---SPSELRDLLSEF----NVLK 780 Query: 487 SLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++HP+V+ YG DG L + E+ GSL+ FL Sbjct: 781 QVNHPHVIKLYGAC--SQDGPLLLIVEYAKYGSLRGFL 816
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 47.4 bits (111), Expect = 4e-05 Identities = 33/100 (33%), Positives = 51/100 (51%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +K+DD E I ELG+G G V + + + + R K + +P+ R ++I +E Q+ Sbjct: 65 LKDDDFERISELGAGNGGVVTKVQHKPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 119 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L + P +V FYG DG ++ E M GSL Q L Sbjct: 120 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 157
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 47.4 bits (111), Expect = 4e-05 Identities = 34/94 (36%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 681 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-----TEKQR--RDFLGEASIMGQFDH 733 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PN++ GVV + VTE+M NGSL FL Sbjct: 734 PNIIHLEGVVTKSK--PVMIVTEYMENGSLDTFL 765
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 47.4 bits (111), Expect = 4e-05 Identities = 34/115 (29%), Positives = 52/115 (45%), Gaps = 1/115 (0%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPS 435 +P + K I + L+ K+LG+G +G V+ + + VA+K +K Sbjct: 240 SPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS---- 295 Query: 436 ERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F EA ++ SL H +V + VV P + VTEFM GSL FL Sbjct: 296 -----VEAFLAEANLMKSLQHDKLVKLHAVVSQEP---IFIVTEFMAKGSLLDFL 342
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 47.4 bits (111), Expect = 4e-05 Identities = 29/93 (31%), Positives = 49/93 (52%), Gaps = 2/93 (2%) Frame = +1 Query: 328 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 501 K LG G +G V+ + G ++A K+++ FD E + ++ E Q+L +L H Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQ---FDPDSPETSKEVSALECEIQLLKNLQHE 422 Query: 502 NVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +V +YG +RD + +L E+M GS+K L Sbjct: 423 RIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQL 455
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 47.4 bits (111), Expect = 4e-05 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K +K++DL +++G G +G VF G+ R + VA+K SC + P + L Sbjct: 546 AVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVK----SCRETLPPD---L 598 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL +HPN+V GV Sbjct: 599 KAKFLQEARILKQYNHPNIVRLIGV 623
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 47.4 bits (111), Expect = 4e-05 Identities = 31/114 (27%), Positives = 57/114 (50%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSE 438 TP+ L+ +K +L+ +K LGSG +G+V+ G W +K I + + Sbjct: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETT 757 Query: 439 RERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + +F EA I++S+ HP++V GV ++ VT+ M +G L +++ Sbjct: 758 GPKANVEFMDEALIMASMDHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYV 808
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 47.4 bits (111), Expect = 4e-05 Identities = 46/177 (25%), Positives = 77/177 (43%), Gaps = 15/177 (8%) Frame = +1 Query: 115 VQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGL 294 VQ A+ N+ N G D G P S + S S E ++L+ Sbjct: 232 VQLTAQSFNTDAAGNRGGG---DGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDK 288 Query: 295 QTIKN--------------DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRP 432 + +KN +++ +K +G+G++G+VF G+W G DVA+K +K + +P Sbjct: 289 KKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QP 343 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYG-VVRDGPDGSLATVTEFMVNGSLKQFL 600 + + F E Q+L H N++ F G + R G A +T++ SL L Sbjct: 344 TAEQ--AQAFKNEMQVLRKTRHVNILLFMGFMTRPG----FAIITQWCEGSSLYHHL 394
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 47.4 bits (111), Expect = 4e-05 Identities = 36/94 (38%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 691 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNVV GVV G + V EFM NG+L FL Sbjct: 692 PNVVHLEGVVTRGK--PVMIVIEFMENGALDAFL 723
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 47.4 bits (111), Expect = 4e-05 Identities = 36/94 (38%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 639 IGAGEFGEVCSGRLKLPGQRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 691 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNVV GVV G + V EFM NG+L FL Sbjct: 692 PNVVHLEGVVTRGK--PVMIVIEFMENGALDAFL 723
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 47.4 bits (111), Expect = 4e-05 Identities = 36/94 (38%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 691 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNVV GVV G + V EFM NG+L FL Sbjct: 692 PNVVHLEGVVTRGK--PVMIVIEFMENGALDAFL 723
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 47.4 bits (111), Expect = 4e-05 Identities = 48/192 (25%), Positives = 86/192 (44%), Gaps = 4/192 (2%) Frame = +1 Query: 28 ISENRLNFLPEFVASVK--KAALEESEKPVEVQPDARPANSPVCDNDKDGKKFDENTDGD 201 +SE+ ++P V ++ +AA + S K P P++S V +++ + T + Sbjct: 121 VSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPF--PSSSGVSNSNNNRTS---TTATE 175 Query: 202 QDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG 381 + P + + H S+ + + E L+ D LG G +G V+ GKW+ Sbjct: 176 EIPSLESLGNIHISTVQRAAESLLEIDYAELENA-TDGWSPDNRLGQGGFGDVYRGKWKQ 234 Query: 382 CDVAIK--RIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLA 555 DVAIK ++ D + E + + E + L+S+ H N+++ YG G G Sbjct: 235 LDVAIKVMNYRSPNIDQKMVE----LQQSYNELKYLNSIRHDNILALYGYSIKG--GKPC 288 Query: 556 TVTEFMVNGSLK 591 V + M GSL+ Sbjct: 289 LVYQLMKGGSLE 300
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 47.0 bits (110), Expect = 5e-05 Identities = 32/101 (31%), Positives = 50/101 (49%), Gaps = 5/101 (4%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 D+E ++ELG G +G V+ G+ VAIK +K + + DF +E + Sbjct: 409 DVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENA-------SVKTQQDFKREIE 461 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++S L H N+V GVV + + E+M NG L +FL Sbjct: 462 LISDLKHQNIVCILGVVLN--KEPYCMLFEYMANGDLHEFL 500
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 47.0 bits (110), Expect = 5e-05 Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 2/113 (1%) Frame = +1 Query: 268 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSER 441 E E +G +D +++++G GTYG V+ GK R + VA+K+I+ SE Sbjct: 6 EGEVAHEGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLE------SED 59 Query: 442 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 E + + +E +L L HPNVV V+ + L + EF+ + LK+++ Sbjct: 60 EGVPSTAVREISLLKELQHPNVVGLEAVIMQ--ENRLFLIFEFL-SFDLKRYM 109
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 47.0 bits (110), Expect = 5e-05 Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 2/103 (1%) Frame = +1 Query: 298 TIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKE 471 T + +++++LG GTY +V+ G+ R G VA+K I +G PS R E Sbjct: 2 TGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIR-------E 54 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H N+V+ Y V+ + L V EFM + LK+++ Sbjct: 55 ISLMKELDHENIVTLYDVIH--TENKLTLVFEFM-DKDLKKYM 94
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 47.0 bits (110), Expect = 5e-05 Identities = 31/103 (30%), Positives = 53/103 (51%), Gaps = 2/103 (1%) Frame = +1 Query: 298 TIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKE 471 T + +++++LG GTY +V+ G+ R G VA+K I +G PS R E Sbjct: 2 TGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIR-------E 54 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H N+V+ Y V+ + L V E+M + LK+++ Sbjct: 55 ISLMKELDHENIVTLYDVIH--TENKLTLVFEYM-DKDLKKYM 94
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 47.0 bits (110), Expect = 5e-05 Identities = 31/114 (27%), Positives = 57/114 (50%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSE 438 TP+ L+ +K +L+ +K LGSG +G+V+ G W +K I + + Sbjct: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETT 757 Query: 439 RERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + +F EA I++S+ HP++V GV ++ VT+ M +G L +++ Sbjct: 758 GPKANVEFMDEALIMASVDHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYV 808
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 47.0 bits (110), Expect = 5e-05 Identities = 32/97 (32%), Positives = 50/97 (51%), Gaps = 6/97 (6%) Frame = +1 Query: 328 KELGSGTYGSVFHGKWRGCD------VAIKRIKASCFDGRPSERERLIADFWKEAQILSS 489 K +G+G +G V+ G + VAIK +KA +E++R+ DF EA I+ Sbjct: 618 KVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGY-----TEKQRV--DFLSEASIMGQ 670 Query: 490 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 H N++ GVV + +TE+M NG+L +FL Sbjct: 671 FSHHNIIPLEGVV--SKYKPMMIITEYMENGALDKFL 705
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 47.0 bits (110), Expect = 5e-05 Identities = 37/112 (33%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Frame = +1 Query: 286 KGLQTIKNDDLEEIKELGSGTYG------SVFHGKWRGCDVAIKR-IKASCFDGRPSERE 444 K + +N E I+ LGSGT+ V GKW + KR I + + R +E Sbjct: 157 KNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEM- 215 Query: 445 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F +E IL SLHHP VV + + + D L V E++ G L FL Sbjct: 216 -----FQREIDILKSLHHPGVVQCHEIFEN--DDELFIVMEYVEGGDLMDFL 260
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 47.0 bits (110), Expect = 5e-05 Identities = 34/94 (36%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 657 IGAGEFGEVCSGRLKLQGKREFPVAIKTLKVGY-----TEKQR--RDFLGEASIMGQFDH 709 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PN++ GVV + VTE+M NGSL FL Sbjct: 710 PNIIHLEGVVTKSK--PVMIVTEYMENGSLDTFL 741
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 624 KVIGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 676 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + +TE+M NGSL FL Sbjct: 677 DHPNIIHLEGVVTKCK--PVMIITEYMENGSLDAFL 710
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 46.6 bits (109), Expect = 6e-05 Identities = 33/99 (33%), Positives = 53/99 (53%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G K G V +K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVTMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+VS V+ D L + EF+ + LK++L Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 46.6 bits (109), Expect = 6e-05 Identities = 33/103 (32%), Positives = 52/103 (50%), Gaps = 7/103 (6%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCD-------VAIKRIKASCFDGRPSERERLIADFWKE 471 +L+ I LG G +G VF K +G + V +K ++ + E+L DF +E Sbjct: 776 NLQTITTLGRGEFGEVFLAKAKGAEDAEGEALVLVKSLQ--------TRDEQLQLDFRRE 827 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 A++ L+H NVV G+ R+ + V E++ G LKQFL Sbjct: 828 AEMFGKLNHVNVVRLLGLCREAEPHYM--VLEYVDLGDLKQFL 868
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 46.6 bits (109), Expect = 6e-05 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 3/99 (3%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGS---VFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKE 471 +KN+DL+ + ELG+G G+ V H K + K D +PS R++++ +E Sbjct: 104 LKNEDLKTLSELGAGNGGTVTKVLHEK----SGTVMAKKVVFIDAKPSVRKQIL----RE 155 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSL 588 QIL + P +VSFYG + P + EFM SL Sbjct: 156 LQILHECNSPYIVSFYGAYLNEP--HICMCMEFMQKDSL 192
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 46.6 bits (109), Expect = 6e-05 Identities = 40/128 (31%), Positives = 58/128 (45%), Gaps = 15/128 (11%) Frame = +1 Query: 262 PAEAEALSKGLQTIKNDDLEEI---------KELGSGTYGSVFHGKW-----RGCDVAIK 399 P KG QT+KN+ + I KELG G +GSV G W + +VA+K Sbjct: 457 PNSVNVGQKGDQTMKNNAQQNIILKESISFGKELGVGEFGSVIKGIWLSPGGKEINVAMK 516 Query: 400 RI-KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMV 576 + K G +F +EA ++S L+HP +VS GV P + V E + Sbjct: 517 TLHKDKMVQGE--------KEFLREALVMSQLNHPCIVSLLGVCLGPP---MILVQELVE 565 Query: 577 NGSLKQFL 600 G+L +L Sbjct: 566 MGALLDYL 573
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/99 (35%), Positives = 53/99 (53%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 DD +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 DDYLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLE------SEEEGVPSTAVREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPNVV V+ + L V EF+ + LK++L Sbjct: 56 KELQHPNVVRLLDVLMQ--ESKLYLVFEFL-SMDLKKYL 91
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 625 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 677 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + +TE+M NGSL FL Sbjct: 678 DHPNIIHLEGVVTKCK--PVMIITEYMENGSLDAFL 711
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 625 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 677 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + +TE+M NGSL FL Sbjct: 678 DHPNIIHLEGVVTKCK--PVMIITEYMENGSLDAFL 711
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 625 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 677 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + +TE+M NGSL FL Sbjct: 678 DHPNIIHLEGVVTKCK--PVMIITEYMENGSLDAFL 711
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 46.6 bits (109), Expect = 6e-05 Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Frame = +1 Query: 328 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 624 KVIGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 676 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN++ GVV + +TE+M NGSL FL Sbjct: 677 DHPNIIHLEGVVTKCK--PVMIITEYMENGSLDAFL 710
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 46.2 bits (108), Expect = 8e-05 Identities = 33/115 (28%), Positives = 52/115 (45%), Gaps = 1/115 (0%) Frame = +1 Query: 259 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPS 435 +P + K I + L+ K+LG+G +G V+ + + VA+K +K Sbjct: 219 SPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS---- 274 Query: 436 ERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + F EA ++ +L H +V + VV P + VTEFM GSL FL Sbjct: 275 -----VEAFLAEANLMKTLQHDKLVKLHAVVSQEP---IFIVTEFMAKGSLLDFL 321
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 46.2 bits (108), Expect = 8e-05 Identities = 33/94 (35%), Positives = 46/94 (48%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VA K +K +E++R DF EA I+ H Sbjct: 683 IGAGEFGEVCSGRLKLPGKRELPVATKTLKVGY-----TEKQR--RDFLSEASIMGQFDH 735 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PN++ GVV + VTE+M NGSL FL Sbjct: 736 PNIIHLEGVVTKSK--PVMIVTEYMENGSLDTFL 767
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 46.2 bits (108), Expect = 8e-05 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 634 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 686 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PNVV GVV G + V E+M NG+L FL Sbjct: 687 PNVVHLEGVVTRGK--PVMIVIEYMENGALDAFL 718
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 46.2 bits (108), Expect = 8e-05 Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 1/108 (0%) Frame = +1 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIA 456 ++K I + L ++LG+G +G V+ G W VA+K +K A Sbjct: 228 IAKDAWEIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSP---------A 278 Query: 457 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F EA ++ L H ++V Y + D + VTE+M GSL +L Sbjct: 279 SFLDEAGVMKKLRHKHLVQLYAICSDRE--PIYIVTEYMSGGSLLDYL 324
>FAK1_XENLA (Q91738) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1068 Score = 46.2 bits (108), Expect = 8e-05 Identities = 49/202 (24%), Positives = 87/202 (43%), Gaps = 11/202 (5%) Frame = +1 Query: 28 ISENRLNFLPEFVASVKKAALEESEKPVEVQPDARPANSPVCDNDKDGKK-----FDENT 192 I+EN + + + V A+ +P + A P+ + +N+K G + + Sbjct: 336 IAENMADLIDGYCRLVSGASESFIIRPQKEGERALPSIPKLANNEKHGVRPHAVSVSDEF 395 Query: 193 DGDQDPDVHGSCDQHKSSGIESTPAEAEALSK-GLQTIKNDDLEEIKELGSGTYGSVFHG 369 GD+ D D+ + + P+++ L + G I+ D +E + +G G +G V G Sbjct: 396 SGDETDDYAEIIDEEDTY---TMPSKSYGLDEAGDYEIQRDRIELGRCIGEGQFGDVHQG 452 Query: 370 KWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRD 534 + + VAIK K D S RE+ F +EA + HP++V GV+ + Sbjct: 453 VYMSPENPAMAVAIKTCKNCTSD---SVREK----FLQEALTMRQFDHPHIVKLIGVITE 505 Query: 535 GPDGSLATVTEFMVNGSLKQFL 600 P + + E G L+ FL Sbjct: 506 NP---VWIIMELCTLGELRSFL 524
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 46.2 bits (108), Expect = 8e-05 Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 2/93 (2%) Frame = +1 Query: 328 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 501 K LG G +G V+ + G ++A K+++ FD E + ++ E Q+L +L H Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQ---FDPDSPETSKEVSALECEIQLLKNLQHE 422 Query: 502 NVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +V +YG +RD + L E+M GS+K L Sbjct: 423 RIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQL 455
>PR2_DROME (Q9I7F7) Tyrosine-protein kinase PR2 (EC 2.7.10.2)| Length = 1337 Score = 46.2 bits (108), Expect = 8e-05 Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 4/104 (3%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIK-RIKASCFDGRPSERERLIA---DFWK 468 I D + K+LG+G +G V G W + I+ IK C RER+ + +F K Sbjct: 128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLC-------RERMQSNPMEFLK 180 Query: 469 EAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 EA I+ S+ H N+V YGVV SL VTE SL + L Sbjct: 181 EAAIMHSIEHENIVRLYGVVL--ATDSLMLVTELAHLRSLLECL 222
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 45.8 bits (107), Expect = 1e-04 Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 7/102 (6%) Frame = +1 Query: 316 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWK-EA 474 L++I++LG G +G V G VA+K +KA C P R WK E Sbjct: 897 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADC---GPQHRSG-----WKQEI 948 Query: 475 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL +L+H +++ + G D + SL V E++ GSL+ +L Sbjct: 949 DILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL 990 Score = 32.3 bits (72), Expect = 1.2 Identities = 30/139 (21%), Positives = 58/139 (41%), Gaps = 21/139 (15%) Frame = +1 Query: 247 GIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR---------------- 378 G ++P + ++ ++ LG GT +V+ G+ R Sbjct: 566 GARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDED 625 Query: 379 ----GCDVAIK-RIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD 543 G D + R+ D PS + +A F++ A ++S + H ++ +GV GP+ Sbjct: 626 PLVPGRDRGQELRVVLKVLD--PSHHDIALA-FYETASLMSQVSHTHLAFVHGVCVRGPE 682 Query: 544 GSLATVTEFMVNGSLKQFL 600 + VTE++ +G L +L Sbjct: 683 NIM--VTEYVEHGPLDVWL 699
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 2/100 (2%) Frame = +1 Query: 307 NDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 + +++++LG GTY +V+ G+ R G VA+K I +G PS R E + Sbjct: 4 SSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIR-------EISL 56 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + L H N+V+ Y V+ + L V E+M + LK+F+ Sbjct: 57 MKELKHENIVTLYDVIH--TENKLNLVFEYM-DKDLKKFM 93
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 45.8 bits (107), Expect = 1e-04 Identities = 49/166 (29%), Positives = 69/166 (41%), Gaps = 5/166 (3%) Frame = +1 Query: 106 PVEVQP--DARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 279 P+E+ P D RP +SPV KDGK F T S P Sbjct: 12 PLELSPSADLRPCSSPVVIPGKDGKAFLGGTP---------------SPRTRRLPPRLAW 56 Query: 280 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 459 S I D L ++ LGSG +G+V+ + G VA+K++K S + S + Sbjct: 57 CS-----IDWDRLCLLQPLGSGGFGAVYKATYHGVTVAVKQVKKSSKNRLASRQ-----S 106 Query: 460 FWKEAQILSSLHHPNVVSFYGVVRDGP--DGSLAT-VTEFMVNGSL 588 FW E + + L H NVV P SL T + E++ N +L Sbjct: 107 FWAELNV-ARLQHDNVVRVVAASTCAPASQNSLGTIIMEYVGNVTL 151
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 45.8 bits (107), Expect = 1e-04 Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 1/96 (1%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSL 492 LEEI +G G +G V+ WRG +VA+K + P + + A+ +EA++ +L Sbjct: 100 LEEI--IGVGGFGKVYRALWRGEEVAVKAARLD-----PEKDPAVTAEQVCQEARLFGAL 152 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN+++ G + P L V E+ G+L + L Sbjct: 153 QHPNIIALRGACLNPP--HLCLVMEYARGGALSRVL 186
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 45.8 bits (107), Expect = 1e-04 Identities = 35/100 (35%), Positives = 50/100 (50%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V G+ R VAIK +K +ER+R DF EA I Sbjct: 625 IEEV--IGAGEFGEVCRGRLKLPGRREIFVAIKTLKVGY-----TERQR--RDFLSEASI 675 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM N +L FL Sbjct: 676 MGQFDHPNIIHLEGVVT--KSRPVMIITEFMENCALDSFL 713
>ACK1_MOUSE (O54967) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1)| (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Length = 1055 Score = 45.8 bits (107), Expect = 1e-04 Identities = 29/96 (30%), Positives = 43/96 (44%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 I DL +++LG G++G V G+W + C + + DF +E Sbjct: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSL 588 + SL H N++ YGVV P + VTE GSL Sbjct: 181 MHSLDHRNLIRLYGVVLTLP---MKMVTELAPLGSL 213
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/99 (31%), Positives = 53/99 (53%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ + +++G GTYG V+ + G DVA+K+I+ E E + + +E +L Sbjct: 6 DNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLE------GETEGVPSTAIREISLL 59 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +L HPNVV + VV G +L + E++ N LK+ + Sbjct: 60 KNLKHPNVVQLFDVVISG--NNLYMIFEYL-NMDLKKLM 95
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 1/96 (1%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSL 492 LEE+ +G G +G V+ G WRG VA+K + P E + A+ +EA++ + L Sbjct: 119 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQD-----PDEDISVTAESVRQEARLFAML 171 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN+++ V + P +L V E+ G L + L Sbjct: 172 AHPNIIALKAVCLEEP--NLCLVMEYAAGGPLSRAL 205
>WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 2/119 (1%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 IE +A +S + +K D E+G G++ +V+ G V + + Sbjct: 204 IEELETKAVGMSNDGRFLKFDI-----EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLT 258 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS--LATVTEFMVNGSLKQFL 600 SER+R F +EA++L L HPN+V FY G + VTE M +G+LK +L Sbjct: 259 KSERQR----FKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYL 313
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 45.4 bits (106), Expect = 1e-04 Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 6/121 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 52 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDL 110 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD--GSLAT-VTEFMVNGSLKQF 597 R S+R FW E I + L H N+V P+ SL T + EF N +L Q Sbjct: 111 RASQR-----SFWAELNI-AGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQV 164 Query: 598 L 600 + Sbjct: 165 I 165
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 45.4 bits (106), Expect = 1e-04 Identities = 34/94 (36%), Positives = 46/94 (48%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G+G +G V G R VAIK +K +E++R DF EA I+ H Sbjct: 520 IGAGEFGEVCSGCLKLPGKRELPVAIKTLKVGY-----TEKQR--RDFLGEASIMGQFDH 572 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PN++ GVV + VTE+M NGSL FL Sbjct: 573 PNIIHLEGVVTKSK--PVMIVTEYMENGSLDTFL 604
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/85 (34%), Positives = 46/85 (54%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K + D P + + F E +L H N++ Sbjct: 346 IGSGSFGTVYKGKWHG-DVAVKILKVT--DPTPEQ----LQAFRNEVAVLRKTRHVNILL 398 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSL 588 F G + +LA VT++ SL Sbjct: 399 FMGYM---TKDNLAIVTQWCEGSSL 420
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/89 (33%), Positives = 47/89 (52%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 30 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 82 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G + +LA VT++ SL + L Sbjct: 83 FMGYM---TKDNLAIVTQWCEGSSLYKHL 108
>WNK1_RAT (Q9JIH7) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2126 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 2/119 (1%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 IE +A +S + +K D E+G G++ +V+ G V + + Sbjct: 204 IEELETKAVGMSNDGRFLKFDI-----EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLT 258 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS--LATVTEFMVNGSLKQFL 600 SER+R F +EA++L L HPN+V FY G + VTE M +G+LK +L Sbjct: 259 KSERQR----FKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYL 313
>WNK1_MOUSE (P83741) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2377 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 2/119 (1%) Frame = +1 Query: 250 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 429 IE +A +S + +K D E+G G++ +V+ G V + + Sbjct: 204 IEELETKAVGMSNDGRFLKFDI-----EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLT 258 Query: 430 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS--LATVTEFMVNGSLKQFL 600 SER+R F +EA++L L HPN+V FY G + VTE M +G+LK +L Sbjct: 259 KSERQR----FKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYL 313
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 45.4 bits (106), Expect = 1e-04 Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 6/121 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDL 130 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD--GSLAT-VTEFMVNGSLKQF 597 R S+R FW E I + L H N+V P+ SL T + EF N +L Q Sbjct: 131 RASQR-----SFWAELNI-AGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQV 184 Query: 598 L 600 + Sbjct: 185 I 185
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/99 (30%), Positives = 55/99 (55%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 ++ ++++++G GTYG V+ + R G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L+HPN+V V+ + L V EF+ N LK+F+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL-NQDLKKFM 91
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 45.4 bits (106), Expect = 1e-04 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 4/152 (2%) Frame = +1 Query: 145 PVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEE 324 P CD D+ +N + P S ++KS + T + + + N D Sbjct: 126 PFCDKDRTLMTPVQNLEQSYMPP-DSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 184 Query: 325 IK----ELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 492 I ++G G +G V+ G VA+K++ A E L F +E ++++ Sbjct: 185 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMV----DITTEELKQQFDQEIKVMAKC 240 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSL 588 H N+V G DG D L V +M NGSL Sbjct: 241 QHENLVELLGFSSDGDD--LCLVYVYMPNGSL 270
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 + + L+ ++ LG+G +G V+ G + VA+K +K F EA Sbjct: 239 VPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDA---------FLAEAN 289 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H +V Y VV + P + +TE+M NGSL FL Sbjct: 290 LMKQLQHKRLVRLYAVVTEEP---IYIITEYMENGSLVDFL 327
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/89 (33%), Positives = 47/89 (52%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G + +LA VT++ SL + L Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSSLYKHL 433
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/89 (33%), Positives = 47/89 (52%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G + +LA VT++ SL + L Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSSLYKHL 433
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 45.4 bits (106), Expect = 1e-04 Identities = 34/94 (36%), Positives = 46/94 (48%), Gaps = 5/94 (5%) Frame = +1 Query: 334 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 498 +G G +G V G+ R VAIK +KA D ++R DF EA I+ H Sbjct: 1 IGIGEFGEVCSGRLKMPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQFDH 53 Query: 499 PNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 PN++ GVV + +TE+M NGSL FL Sbjct: 54 PNIIRLEGVVTKCK--PVMIITEYMENGSLDAFL 85
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 7/103 (6%) Frame = +1 Query: 313 DLEEIKELGSGTYGSVFHGKWRGCD-------VAIKRIKASCFDGRPSERERLIADFWKE 471 D+ ++ LG G +G VF + G VA+K +K D ++ DF +E Sbjct: 440 DIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASD-------QMQMDFERE 492 Query: 472 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 A +L+ HPN+V GV G + + E+M G L +FL Sbjct: 493 ACLLAEFDHPNIVRLLGVCALG--RPMCLLFEYMAPGDLSEFL 533
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/89 (33%), Positives = 47/89 (52%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G + +LA VT++ SL + L Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSSLYKHL 433
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 45.1 bits (105), Expect = 2e-04 Identities = 35/100 (35%), Positives = 50/100 (50%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V G+ R VAIK +K +ER+R DF EA I Sbjct: 635 IEEV--IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-----TERQR--RDFLSEASI 685 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM N +L FL Sbjct: 686 MGQFDHPNIIRLEGVVT--KSRPVMILTEFMENCALDSFL 723
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/91 (36%), Positives = 45/91 (49%), Gaps = 2/91 (2%) Frame = +1 Query: 334 LGSGTYGSVFHGKW--RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 507 LG G +G V+ G+ G VA+K++ + G +F E +LS LHHPN+ Sbjct: 92 LGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGN--------REFLVEVLMLSLLHHPNL 143 Query: 508 VSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 V+ G DG L V EFM GSL+ L Sbjct: 144 VNLIGYCADGDQRLL--VYEFMPLGSLEDHL 172
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 45.1 bits (105), Expect = 2e-04 Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 6/121 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 41 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 99 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD--GSLAT-VTEFMVNGSLKQF 597 R S+R FW E I + L H N+V P+ SL T + EF N +L Q Sbjct: 100 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQV 153 Query: 598 L 600 + Sbjct: 154 I 154
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/99 (31%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ +I+++G GTYG V+ G+ + G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+V V+ D L + EF+ + LK++L Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/116 (28%), Positives = 58/116 (50%), Gaps = 3/116 (2%) Frame = +1 Query: 262 PAEAEALSKGLQTIKN-DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRP 432 P+ AL + ++ DD + +++G+G + V+ + R G + +K K P Sbjct: 33 PSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL------P 86 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 S R + +E Q+++ L HPN++ F GV G L +TE+M G+L+Q L Sbjct: 87 SNRSNTL----REVQLMNRLRHPNILRFMGVCVH--QGQLHALTEYMNGGTLEQLL 136
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 45.1 bits (105), Expect = 2e-04 Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 6/121 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 130 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD--GSLAT-VTEFMVNGSLKQF 597 R S+R FW E I + L H N+V P+ SL T + EF N +L Q Sbjct: 131 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQV 184 Query: 598 L 600 + Sbjct: 185 I 185
>WNK4_RAT (Q7TPK6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 45.1 bits (105), Expect = 2e-04 Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 2/133 (1%) Frame = +1 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 PD + + E T +A A S + +K D E+G G++ +V+ G Sbjct: 140 PDAAARERRREQEEKEDTETQAVATSPDGRYLKFDI-----EIGRGSFKTVYRGLDTDTT 194 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS--LATV 561 V + + +ER+R F +E ++L L HPN+V FY + G + V Sbjct: 195 VEVAWCELQTRKLSRAERQR----FSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLV 250 Query: 562 TEFMVNGSLKQFL 600 TE M +G+LK +L Sbjct: 251 TELMTSGTLKTYL 263
>WNK4_MOUSE (Q80UE6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 45.1 bits (105), Expect = 2e-04 Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 2/133 (1%) Frame = +1 Query: 208 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 387 PD + + E T +A A S + +K D E+G G++ +V+ G Sbjct: 140 PDAAARERRREQEEKEDTETQAVATSPDGRYLKFDI-----EIGRGSFKTVYRGLDTDTT 194 Query: 388 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGS--LATV 561 V + + +ER+R F +E ++L L HPN+V FY + G + V Sbjct: 195 VEVAWCELQTRKLSRAERQR----FSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLV 250 Query: 562 TEFMVNGSLKQFL 600 TE M +G+LK +L Sbjct: 251 TELMTSGTLKTYL 263
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 45.1 bits (105), Expect = 2e-04 Identities = 35/100 (35%), Positives = 50/100 (50%), Gaps = 5/100 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 480 +EE+ +G+G +G V G+ R VAIK +K +ER+R DF EA I Sbjct: 630 IEEV--IGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGY-----TERQR--RDFLSEASI 680 Query: 481 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 + HPN++ GVV + +TEFM N +L FL Sbjct: 681 MGQFDHPNIIRLEGVVT--KSRPVMILTEFMENCALDSFL 718
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/99 (29%), Positives = 55/99 (55%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 + ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L+HPN+V + V+ + L V EF+ + LK+F+ Sbjct: 56 KELNHPNIVKLHDVIH--TENKLYLVFEFL-HQDLKRFM 91
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 45.1 bits (105), Expect = 2e-04 Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 6/121 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 88 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 146 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD--GSLAT-VTEFMVNGSLKQF 597 R S+R FW E I + L H N+V P+ SL T + EF N +L Q Sbjct: 147 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQV 200 Query: 598 L 600 + Sbjct: 201 I 201
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 45.1 bits (105), Expect = 2e-04 Identities = 25/59 (42%), Positives = 34/59 (57%), Gaps = 1/59 (1%) Frame = +1 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGSLKQFL 600 RP + DF KE +I+S L PN++ GV V+D P L +T++M NG L QFL Sbjct: 654 RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP---LCMITDYMENGDLNQFL 709
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 45.1 bits (105), Expect = 2e-04 Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKA 411 + SGI T A+ K + ++D+ + +G G +G VF G+ R + VA+K Sbjct: 250 RKSGIVLT----RAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVK---- 301 Query: 412 SCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLK 591 SC + P E L A F +EA+IL +HPN+V GV + V E + G Sbjct: 302 SCRETLPPE---LKAKFLQEARILKQYNHPNIVRLIGVCTQ--KQPIYIVMELVQGGDFL 356 Query: 592 QFL 600 FL Sbjct: 357 SFL 359
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/116 (28%), Positives = 58/116 (50%), Gaps = 3/116 (2%) Frame = +1 Query: 262 PAEAEALSKGLQTIKN-DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRP 432 P+ AL + ++ DD + +++G+G + V+ + R G + +K K P Sbjct: 33 PSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL------P 86 Query: 433 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 S R + +E Q+++ L HPN++ F GV G L +TE+M G+L+Q L Sbjct: 87 SNRSNTL----REVQLMNRLRHPNILRFMGVCVH--QGQLHALTEYMNGGTLEQLL 136
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 45.1 bits (105), Expect = 2e-04 Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 6/121 (4%) Frame = +1 Query: 256 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 426 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 130 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPD--GSLAT-VTEFMVNGSLKQF 597 R S+R FW E I + L H N+V P+ SL T + EF N +L Q Sbjct: 131 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQV 184 Query: 598 L 600 + Sbjct: 185 I 185
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 45.1 bits (105), Expect = 2e-04 Identities = 35/110 (31%), Positives = 50/110 (45%), Gaps = 10/110 (9%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG--------CDVAIKRI--KASCFDGRPSERERL 450 + D ++ IKELG G++G V+ G +G VA+K + +AS D R Sbjct: 1032 VDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDRR------- 1084 Query: 451 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 +F KEA + H +VV GVV G + E M G LK +L Sbjct: 1085 --EFLKEATTMKEFHCHHVVKLLGVVSTGQPA--LVIMELMALGDLKNYL 1130
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/89 (33%), Positives = 47/89 (52%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 88 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 140 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G + +LA VT++ SL + L Sbjct: 141 FMGYM---TKDNLAIVTQWCEGSSLYKHL 166
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 1/101 (0%) Frame = +1 Query: 301 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 + + L+ ++ LG+G +G V+ G + VA+K +K F EA Sbjct: 239 VPRETLKLVERLGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDA---------FLAEAN 289 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 ++ L H +V Y VV P + +TE+M NGSL FL Sbjct: 290 LMKQLQHQRLVRLYAVVTQEP---IYIITEYMENGSLVDFL 327
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 45.1 bits (105), Expect = 2e-04 Identities = 25/59 (42%), Positives = 34/59 (57%), Gaps = 1/59 (1%) Frame = +1 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGSLKQFL 600 RP + DF KE +I+S L PN++ GV V+D P L +T++M NG L QFL Sbjct: 656 RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP---LCMITDYMENGDLNQFL 711
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/89 (33%), Positives = 47/89 (52%) Frame = +1 Query: 334 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 513 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 407 Query: 514 FYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 F G + +LA VT++ SL + L Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSSLYKHL 433
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 45.1 bits (105), Expect = 2e-04 Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%) Frame = +1 Query: 238 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKA 411 + SGI T A+ K + ++D+ + +G G +G VF G+ R + VA+K Sbjct: 590 RKSGIVLT----RAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVK---- 641 Query: 412 SCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLK 591 SC + P E L A F +EA+IL +HPN+V GV + V E + G Sbjct: 642 SCRETLPPE---LKAKFLQEARILKQCNHPNIVRLIGVCTQ--KQPIYIVMELVQGGDFL 696 Query: 592 QFL 600 FL Sbjct: 697 SFL 699
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 45.1 bits (105), Expect = 2e-04 Identities = 25/59 (42%), Positives = 34/59 (57%), Gaps = 1/59 (1%) Frame = +1 Query: 427 RPSERERLIADFWKEAQILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGSLKQFL 600 RP + DF KE +I+S L PN++ GV V+D P L +T++M NG L QFL Sbjct: 658 RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP---LCMITDYMENGDLNQFL 713
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +1 Query: 277 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 450 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + L Sbjct: 548 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---L 600 Query: 451 IADFWKEAQILSSLHHPNVVSFYGV 525 A F +EA+IL HPN+V GV Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGV 625
>JAK3_MOUSE (Q62137) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1299 Score = 44.7 bits (104), Expect = 2e-04 Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 5/109 (4%) Frame = +1 Query: 289 GLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLI 453 G + I+ L+ I LG G +GSV ++ D VA+K+++ S G +R Sbjct: 1023 GPRHIEERHLKYISLLGKGNFGSVELCRYDPLDNTGPLVAVKQLQHS---GPDQQR---- 1075 Query: 454 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 DF +E QIL +LH +V + GV SL V E++ +G L+ FL Sbjct: 1076 -DFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 1123
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/96 (33%), Positives = 49/96 (51%), Gaps = 1/96 (1%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSER-ERLIADFWKEAQILSSL 492 LEEI +G G +G V+ W G +VA+K + P E + I + +EA++ + L Sbjct: 146 LEEI--IGIGGFGKVYRAFWIGDEVAVKAARHD-----PDEDISQTIENVRQEAKLFAML 198 Query: 493 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 HPN+++ GV P +L V EF G L + L Sbjct: 199 KHPNIIALRGVCLKEP--NLCLVMEFARGGPLNRVL 232
>JAK3_HUMAN (P52333) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 44.7 bits (104), Expect = 2e-04 Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 6/101 (5%) Frame = +1 Query: 316 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 477 L+ I +LG G +GSV ++ G VA+K+++ S G +R DF +E Q Sbjct: 822 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQR-----DFQREIQ 873 Query: 478 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 IL +LH +V + GV SL V E++ +G L+ FL Sbjct: 874 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 914
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 D+ +I+++G GTYG V+ G K G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPN+V V+ D L + EF+ + LK++L Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEFL-SMDLKKYL 91
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/99 (32%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPNVV V+ + L + EF+ + LK++L Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL-SMDLKKYL 91
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/99 (32%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPNVV V+ + L + EF+ + LK++L Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL-SMDLKKYL 91
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/99 (32%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPNVV V+ + L + EF+ + LK++L Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL-SMDLKKYL 91
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/99 (32%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Frame = +1 Query: 310 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 483 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 484 SSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFL 600 L HPNVV V+ + L + EF+ + LK++L Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL-SMDLKKYL 91 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.313 0.133 0.390 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 86,208,788 Number of Sequences: 219361 Number of extensions: 1674771 Number of successful extensions: 6261 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5404 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5886 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5938641176 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits)
