ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | baal29m11 |
|---|---|
| Clone Library Name | barley_pub |
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 231 bits (589), Expect = 1e-60 Identities = 110/179 (61%), Positives = 144/179 (80%) Frame = +1 Query: 52 LPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL 231 L RYE K LG+G FAKVY ARH+ T + VAIKV+DKE+++K+G +QIKREI+ MR L Sbjct: 8 LMLRYEVGKFLGQGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLL 67 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 RHPNIV+LH+VMA KS+I+ VME+V+GG L+ + + G L+ED R+ FQQLV A+ FCH Sbjct: 68 RHPNIVELHEVMATKSKIYFVMEHVKGGELFNKV-STGKLREDVARKYFQQLVRAVDFCH 126 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 ++GV HRD+KP+NLL+DEHGNLK++DFGLSA +D+ R++ LLHT CGTP YV PEV +R Sbjct: 127 SRGVCHRDLKPENLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISR 185
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 214 bits (546), Expect = 1e-55 Identities = 106/189 (56%), Positives = 143/189 (75%), Gaps = 1/189 (0%) Frame = +1 Query: 28 GAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAV-QQIK 204 G+ + L +YE KLLG G FAKV+ AR T + VA+K+++K+KL+ A+ IK Sbjct: 9 GSGDNNDALFGKYELGKLLGCGAFAKVFHARDRRTGQSVAVKILNKKKLLTNPALANNIK 68 Query: 205 REIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQ 384 REI++MRRL HPNIV+LH+VMA KS+IF ME+V+GG L+ I +G L ED +RR FQQ Sbjct: 69 REISIMRRLSHPNIVKLHEVMATKSKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQ 128 Query: 385 LVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLY 564 L+SA+ +CHA+GVYHRD+KP+NLL+DE+GNLKV+DFGLSA D R + LLHT+CGTP Y Sbjct: 129 LISAVGYCHARGVYHRDLKPENLLIDENGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAY 188 Query: 565 VPPEVFARR 591 V PE+ +++ Sbjct: 189 VAPEILSKK 197
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 204 bits (518), Expect = 2e-52 Identities = 96/177 (54%), Positives = 132/177 (74%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE + +GEG FAKV A++ + E VAIK++DKEK+ K V+QI+REI M+ ++HP Sbjct: 19 KYELGRTIGEGTFAKVRFAKNTENDEPVAIKILDKEKVQKHRLVEQIRREICTMKLVKHP 78 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 N+V+L +VM K+RIF+V+EYV GG L+ I NG LKE+E R+ FQQL++A+ +CH++G Sbjct: 79 NVVRLFEVMGSKARIFIVLEYVTGGELFEIIATNGRLKEEEARKYFQQLINAVDYCHSRG 138 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 VYHRD+K +NLL+D GNLKV+DFGLSA + + + LLHT CGTP YV PEV R Sbjct: 139 VYHRDLKLENLLLDASGNLKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDR 195
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 189 bits (480), Expect = 5e-48 Identities = 94/175 (53%), Positives = 127/175 (72%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE + +GEG FAKV AR+ DT + VAIK+M K ++K V QIKREI++M+ +RHP Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV+L++V+A S+I++V+E+V GG L+ I G L+E E+R+ FQQLV A+ CH +G Sbjct: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 VYHRD+KP+NLL+D +GNLKV+DFGLSA LL T CGTP YV PEV + Sbjct: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--VELLRTTCGTPNYVAPEVLS 182
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 178 bits (451), Expect = 1e-44 Identities = 84/177 (47%), Positives = 124/177 (70%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE + LGEGNF KV A+ + A+K++DK ++ L QIKREI ++ L+HP Sbjct: 19 KYELGRTLGEGNFGKVKFAKDTVSGHSFAVKIIDKSRIADLNFSLQIKREIRTLKMLKHP 78 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +IV+LH+V+A K++I +VME V GG L+ I +NG L E + R++FQQL+ +++CH++G Sbjct: 79 HIVRLHEVLASKTKINMVMELVTGGELFDRIVSNGKLTETDGRKMFQQLIDGISYCHSKG 138 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 V+HRD+K +N+L+D G++K+ DFGLSA R + LLHT CG+P YV PEV A R Sbjct: 139 VFHRDLKLENVLLDAKGHIKITDFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLANR 195
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 158 bits (399), Expect = 1e-38 Identities = 80/194 (41%), Positives = 125/194 (64%) Frame = +1 Query: 1 ANARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK 180 + AR R+ + D Y +K +G+GNFAKV LARH+ T EVAIK++DK +L Sbjct: 35 SGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP 94 Query: 181 LGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKED 360 ++Q++ RE+ +M+ L HPNIV+L +V+ + ++++MEY GG ++ ++ A+G +KE Sbjct: 95 T-SLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEK 153 Query: 361 ETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH 540 E R F+Q+VSA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L Sbjct: 154 EARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSK---LD 210 Query: 541 TVCGTPLYVPPEVF 582 T CG+P Y PE+F Sbjct: 211 TFCGSPPYAAPELF 224
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 157 bits (396), Expect = 3e-38 Identities = 79/191 (41%), Positives = 127/191 (66%) Frame = +1 Query: 10 RPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGA 189 R R+ + ++P + Y +K +G+GNFAKV LARH+ T +EVA+K++DK +L + Sbjct: 36 RGRNSATSADEQPHI-GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSS 93 Query: 190 VQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETR 369 +Q++ RE+ +M+ L HPNIV+L +V+ + +++VMEY GG ++ ++ A+G +KE E R Sbjct: 94 LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153 Query: 370 RIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVC 549 F+Q+VSA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T C Sbjct: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFC 210 Query: 550 GTPLYVPPEVF 582 G+P Y PE+F Sbjct: 211 GSPPYAAPELF 221
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 157 bits (396), Expect = 3e-38 Identities = 79/191 (41%), Positives = 127/191 (66%) Frame = +1 Query: 10 RPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGA 189 R R+ + ++P + Y +K +G+GNFAKV LARH+ T +EVA+K++DK +L + Sbjct: 36 RGRNSATSADEQPHI-GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSS 93 Query: 190 VQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETR 369 +Q++ RE+ +M+ L HPNIV+L +V+ + +++VMEY GG ++ ++ A+G +KE E R Sbjct: 94 LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153 Query: 370 RIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVC 549 F+Q+VSA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T C Sbjct: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFC 210 Query: 550 GTPLYVPPEVF 582 G+P Y PE+F Sbjct: 211 GSPPYAAPELF 221
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 156 bits (395), Expect = 4e-38 Identities = 77/170 (45%), Positives = 114/170 (67%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + +H T +VA+K+++++K+ L V +I+REI ++ RHP+I++L++ Sbjct: 24 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 83 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ S IF+VMEYV GG L+ +I NG L E E+RR+FQQ++S + +CH V HRD+K Sbjct: 84 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLK 143 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D H N K+ADFGLS L T CG+P Y PEV + R Sbjct: 144 PENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 190
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 156 bits (395), Expect = 4e-38 Identities = 77/170 (45%), Positives = 114/170 (67%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + +H T +VA+K+++++K+ L V +I+REI ++ RHP+I++L++ Sbjct: 24 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 83 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ S IF+VMEYV GG L+ +I NG L E E+RR+FQQ++S + +CH V HRD+K Sbjct: 84 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLK 143 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D H N K+ADFGLS L T CG+P Y PEV + R Sbjct: 144 PENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 190
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 156 bits (395), Expect = 4e-38 Identities = 79/194 (40%), Positives = 124/194 (63%) Frame = +1 Query: 1 ANARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK 180 + AR R+ + D Y +K +G+GNFAKV LARH+ T EVAIK++DK +L Sbjct: 35 SGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP 94 Query: 181 LGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKED 360 ++Q++ RE+ +M+ L HPNIV+L +V+ + ++++MEY GG ++ ++ A+G +KE Sbjct: 95 T-SLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEK 153 Query: 361 ETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH 540 E R F+Q+VSA+ +CH + + HRD+K +NLL+D N+K+ DFG S + L Sbjct: 154 EARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKITDFGFSNEFTVGSK---LD 210 Query: 541 TVCGTPLYVPPEVF 582 T CG+P Y PE+F Sbjct: 211 TFCGSPPYAAPELF 224
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 156 bits (395), Expect = 4e-38 Identities = 77/170 (45%), Positives = 114/170 (67%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + +H T +VA+K+++++K+ L V +I+REI ++ RHP+I++L++ Sbjct: 22 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ S IF+VMEYV GG L+ +I NG L E E+RR+FQQ++S + +CH V HRD+K Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLK 141 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D H N K+ADFGLS L T CG+P Y PEV + R Sbjct: 142 PENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 156 bits (395), Expect = 4e-38 Identities = 77/170 (45%), Positives = 114/170 (67%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + +H T +VA+K+++++K+ L V +I+REI ++ RHP+I++L++ Sbjct: 22 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ S IF+VMEYV GG L+ +I NG L E E+RR+FQQ++S + +CH V HRD+K Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLK 141 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D H N K+ADFGLS L T CG+P Y PEV + R Sbjct: 142 PENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 155 bits (392), Expect = 8e-38 Identities = 79/174 (45%), Positives = 116/174 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ VK LGEG+F KV LA H+ T ++VA+K+++K+ L K +I+REI+ +R LRHP+ Sbjct: 39 YQIVKTLGEGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 98 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ V+ K I +V+EY G L+ +I + E E RR FQQ++SA+ +CH + Sbjct: 99 IIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRNKMSEQEARRFFQQIISAVEYCHRHKI 157 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 HRD+KP+NLL+DEH N+K+ADFGLS + L T CG+P Y PEV + Sbjct: 158 VHRDLKPENLLLDEHLNVKIADFGLS---NIMTDGNFLKTSCGSPNYAAPEVIS 208
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 155 bits (391), Expect = 1e-37 Identities = 75/174 (43%), Positives = 115/174 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ K LG G+F KV +A H+ T +VAIK++++ K+ + ++++REI ++R HP+ Sbjct: 20 YKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPH 79 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++ ++V+ S I+VVMEYV+ G L+ +I G L+EDE R FQQ++S + +CH V Sbjct: 80 IIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMV 139 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 HRD+KP+NLL+D N+K+ADFGLS + R L T CG+P Y PEV + Sbjct: 140 VHRDLKPENLLLDSRCNIKIADFGLS---NVMRDGHFLKTSCGSPNYAAPEVIS 190
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 154 bits (389), Expect = 2e-37 Identities = 77/192 (40%), Positives = 123/192 (64%) Frame = +1 Query: 7 ARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLG 186 AR R+ + + Y ++ +G+GNFAKV LARH+ T EVAIK++DK +L Sbjct: 40 ARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPS 98 Query: 187 AVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 ++Q++ RE+ +M+ L HPNIV+L +V+ + +++VMEY G ++ ++ ++G +KE E Sbjct: 99 SLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEA 158 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTV 546 R F+Q+VSA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T Sbjct: 159 RAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK---LDTF 215 Query: 547 CGTPLYVPPEVF 582 CG+P Y PE+F Sbjct: 216 CGSPPYAAPELF 227
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 154 bits (389), Expect = 2e-37 Identities = 77/192 (40%), Positives = 123/192 (64%) Frame = +1 Query: 7 ARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLG 186 AR R+ + + Y ++ +G+GNFAKV LARH+ T EVAIK++DK +L Sbjct: 40 ARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPS 98 Query: 187 AVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 ++Q++ RE+ +M+ L HPNIV+L +V+ + +++VMEY G ++ ++ ++G +KE E Sbjct: 99 SLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEA 158 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTV 546 R F+Q+VSA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T Sbjct: 159 RAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK---LDTF 215 Query: 547 CGTPLYVPPEVF 582 CG+P Y PE+F Sbjct: 216 CGSPPYAAPELF 227
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 154 bits (389), Expect = 2e-37 Identities = 78/184 (42%), Positives = 122/184 (66%) Frame = +1 Query: 31 AMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKRE 210 A ++P + Y K +G+GNFAKV LARH+ T EVA+K++DK +L ++Q++ RE Sbjct: 50 ATDEQPHI-GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPT-SLQKLFRE 107 Query: 211 IAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLV 390 + +M+ L HPNIV+L +V+ + +++VMEY GG ++ ++ A+G +KE E R F+Q+V Sbjct: 108 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 167 Query: 391 SALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP 570 SA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T CG+P Y Sbjct: 168 SAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNK---LDTFCGSPPYAA 224 Query: 571 PEVF 582 PE+F Sbjct: 225 PELF 228
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 154 bits (389), Expect = 2e-37 Identities = 79/174 (45%), Positives = 115/174 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ VK LGEG+F KV LA H T ++VA+K+++K+ L K +I+REI+ +R LRHP+ Sbjct: 55 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 114 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ V+ K I +V+EY G L+ +I + E E RR FQQ++SA+ +CH + Sbjct: 115 IIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKI 173 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 HRD+KP+NLL+DEH N+K+ADFGLS + L T CG+P Y PEV + Sbjct: 174 VHRDLKPENLLLDEHLNVKIADFGLS---NIMTDGNFLKTSCGSPNYAAPEVIS 224
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 154 bits (389), Expect = 2e-37 Identities = 78/184 (42%), Positives = 122/184 (66%) Frame = +1 Query: 31 AMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKRE 210 A ++P + Y K +G+GNFAKV LARH+ T EVA+K++DK +L ++Q++ RE Sbjct: 50 ATDEQPHI-GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPT-SLQKLFRE 107 Query: 211 IAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLV 390 + +M+ L HPNIV+L +V+ + +++VMEY GG ++ ++ A+G +KE E R F+Q+V Sbjct: 108 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 167 Query: 391 SALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP 570 SA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T CG+P Y Sbjct: 168 SAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNK---LDTFCGSPPYAA 224 Query: 571 PEVF 582 PE+F Sbjct: 225 PELF 228
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 154 bits (388), Expect = 2e-37 Identities = 78/184 (42%), Positives = 122/184 (66%) Frame = +1 Query: 31 AMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKRE 210 A ++P + Y K +G+GNFAKV LARH+ T EVA+K++DK +L ++Q++ RE Sbjct: 50 ATDEQPHI-GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPT-SLQKLFRE 107 Query: 211 IAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLV 390 + +M+ L HPNIV+L +V+ + +++VMEY GG ++ ++ A+G +KE E R F+Q+V Sbjct: 108 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 167 Query: 391 SALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP 570 SA+ +CH + + HRD+K +NLL+D N+K+ADFG S + L T CG+P Y Sbjct: 168 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK---LDTFCGSPPYAA 224 Query: 571 PEVF 582 PE+F Sbjct: 225 PELF 228
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 153 bits (387), Expect = 3e-37 Identities = 75/170 (44%), Positives = 113/170 (66%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + H T +VA+K+++++K+ L V +IKREI ++ RHP+I++L++ Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ + F+VMEYV GG L+ +I +G ++E E RR+FQQ++SA+ +CH V HRD+K Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D H N K+ADFGLS L T CG+P Y PEV + R Sbjct: 142 PENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 153 bits (387), Expect = 3e-37 Identities = 75/175 (42%), Positives = 119/175 (68%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RY+ +K LGEG+F KV LA+H+ T ++VA+K+++++ L K +++REI+ +R LRHP Sbjct: 51 RYQIIKTLGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHP 110 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +I++L+ V+ K I +V+E+ G L+ +I G + EDE RR FQQ+++A+ +CH Sbjct: 111 HIIKLYDVIKSKDEIIMVIEFA-GKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHK 169 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 + HRD+KP+NLL+D+ N+K+ADFGLS + L T CG+P Y PEV + Sbjct: 170 IVHRDLKPENLLLDDQLNVKIADFGLS---NIMTDGNFLKTSCGSPNYAAPEVIS 221
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 153 bits (386), Expect = 4e-37 Identities = 75/170 (44%), Positives = 114/170 (67%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + H T +VA+K+++++K+ L V +IKREI ++ RHP+I++L++ Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ + F+VMEYV GG L+ +I +G ++E E RR+FQQ++SA+ +CH V HRD+K Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D H N K+ADFGLS + L T CG+P Y PEV + R Sbjct: 142 PENVLLDAHMNAKIADFGLS---NIMSDGEFLRTSCGSPNYAAPEVISGR 188
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 152 bits (385), Expect = 5e-37 Identities = 77/173 (44%), Positives = 115/173 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ LG+GNFA V L RH TK EVAIK++DK +L + +++I RE+ +M+ L HP+ Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVN-LEKIYREVQIMKMLDHPH 78 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L++VM KS +++V EY + G ++ ++ +G L E E RR F Q++SA+ +CH + V Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKV 138 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 HRD+K +NLL+D + N+K+ADFG T LL T CG+P Y PEVF Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKTGE---LLATWCGSPPYAAPEVF 188
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 152 bits (385), Expect = 5e-37 Identities = 75/189 (39%), Positives = 119/189 (62%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQ 198 SG G+ + Y+ + LG G+F +V +A H T +VAIK++++ K+ + ++ Sbjct: 27 SGTGSRSGVESILPNYKLGRTLGIGSFGRVKIAEHALTGHKVAIKILNRRKIKNMEMEEK 86 Query: 199 IKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIF 378 ++REI ++R HP+I++L++V+ + I++VMEYV G L+ +I G L+EDE R F Sbjct: 87 VRREIKILRLFMHPHIIRLYEVIETPTDIYLVMEYVNSGELFDYIVEKGRLQEDEARNFF 146 Query: 379 QQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTP 558 QQ++S + +CH V HRD+KP+NLL+D N+K+ADFGLS + R L T CG+P Sbjct: 147 QQIISGVEYCHRNMVVHRDLKPENLLLDSKCNVKIADFGLS---NIMRDGHFLKTSCGSP 203 Query: 559 LYVPPEVFA 585 Y PEV + Sbjct: 204 NYAAPEVIS 212
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 152 bits (384), Expect = 7e-37 Identities = 77/191 (40%), Positives = 125/191 (65%) Frame = +1 Query: 10 RPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGA 189 R R+ + ++P + Y +K +G+GNFAKV LARH+ T +EVA+K++DK +L + Sbjct: 36 RGRNSATSADEQPHI-GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSS 93 Query: 190 VQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETR 369 +Q++ RE+ +M+ L HPNIV+L +V+ + +++VMEY GG ++ ++ A+G +KE E R Sbjct: 94 LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153 Query: 370 RIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVC 549 F+Q+V + +CH + + HRD+K +NLL+D N+K+ADFG S + L T C Sbjct: 154 AKFRQIVLHVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFC 210 Query: 550 GTPLYVPPEVF 582 G+P Y PE+F Sbjct: 211 GSPPYAAPELF 221
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 152 bits (383), Expect = 9e-37 Identities = 76/176 (43%), Positives = 121/176 (68%), Gaps = 1/176 (0%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RY+ +K LGEG+F KV LA+H+ T ++VA+K+++++ L K +++REI+ +R LRHP Sbjct: 52 RYQILKTLGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHP 111 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +I++L+ V+ K I +V+E+ G L+ +I G + EDE RR FQQ+++A+ +CH Sbjct: 112 HIIKLYDVIKSKDEIIMVIEFA-GKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHK 170 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP-PEVFA 585 + HRD+KP+NLL+D+ N+K+ADFGLS + L T CG+P Y+P PEV + Sbjct: 171 IVHRDLKPENLLLDDQLNVKIADFGLS---NIMTDGNFLKTSCGSPNYMPAPEVIS 223
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 151 bits (381), Expect = 2e-36 Identities = 75/180 (41%), Positives = 117/180 (65%) Frame = +1 Query: 43 RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM 222 RP Y+ + LG+GNFA V LARH TK +VAIK++DK +L +++I RE+ +M Sbjct: 19 RPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSN-LEKIYREVQIM 77 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 + L HP+I++L++VM K +++V E+ + G ++ H+ +NG L E E R+ F Q++SA+ Sbjct: 78 KLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQILSAVE 137 Query: 403 FCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 +CH+ + HRD+K +NLL+D + N+K+ADFG + L T CG+P Y PEVF Sbjct: 138 YCHSHHIVHRDLKTENLLLDANMNIKLADFGFGNFYKSGEP---LSTWCGSPPYAAPEVF 194
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 150 bits (380), Expect = 2e-36 Identities = 74/168 (44%), Positives = 112/168 (66%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + H T+ +VA+K+++++K+ L V +I+REI + RHP+I++L++ Sbjct: 93 LGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQ 152 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ S IF++ME+V GG L+ +I +G LK E RR FQQ++S + +CH V HRD+K Sbjct: 153 VISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLK 212 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 P+NLL+DE N+K+ADFGLS + L T CG+P Y PEV + Sbjct: 213 PENLLLDEQNNVKIADFGLS---NIMTDGDFLRTSCGSPNYAAPEVIS 257
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 150 bits (379), Expect = 3e-36 Identities = 74/170 (43%), Positives = 112/170 (65%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + H T +VA+K+++++K+ L V +IKREI ++ RHP+I++L++ Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ + F+VMEYV GG L+ +I +G ++E E RR+FQQ++SA+ +CH V HRD+K Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLK 141 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D N K+ADFGLS L T CG+P Y PEV + R Sbjct: 142 PENVLLDAQMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 150 bits (379), Expect = 3e-36 Identities = 74/170 (43%), Positives = 112/170 (65%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G F KV + H T +VA+K+++++K+ L V +IKREI ++ RHP+I++L++ Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ + F+VMEYV GG L+ +I +G ++E E RR+FQQ++SA+ +CH V HRD+K Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+N+L+D N K+ADFGLS L T CG+P Y PEV + R Sbjct: 142 PENVLLDAQMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 150 bits (378), Expect = 3e-36 Identities = 75/173 (43%), Positives = 116/173 (67%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ LG+GNFA V L RH TK EVAIK++DK +L + +++I RE+ +M+ L HP+ Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN-LEKIYREVQIMKMLDHPH 78 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L++VM KS +++V EY + G ++ ++ +G L E E RR F Q++SA+ +CH + + Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 HRD+K +NLL+D + N+K+ADFG + + LL T CG+P Y PEVF Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGF---GNFFKSGELLATWCGSPPYAAPEVF 188
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 149 bits (377), Expect = 5e-36 Identities = 76/191 (39%), Positives = 115/191 (60%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQ 198 + G+ +P +E + LG+G F VYLAR ++ VA+K++ K ++ K G Q Sbjct: 67 ASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQ 126 Query: 199 IKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIF 378 ++REI + L+HPNI+QL+ + RI++++EY G LY+ + + E T I Sbjct: 127 LRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIM 186 Query: 379 QQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTP 558 ++L ALT+CH + V HRDIKP+NLL+ G LK+ADFG S HA + RR+ T+CGT Sbjct: 187 EELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRK----TMCGTL 242 Query: 559 LYVPPEVFARR 591 Y+PPE+ R Sbjct: 243 DYLPPEMIEGR 253
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 149 bits (377), Expect = 5e-36 Identities = 76/188 (40%), Positives = 114/188 (60%) Frame = +1 Query: 28 GAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKR 207 G+ +P +E + LG+G F VYLAR ++ VA+K++ K ++ K G Q++R Sbjct: 68 GSQSRQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRR 127 Query: 208 EIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQL 387 EI + L+HPNI+QL+ + RI++++EY G LY+ + +G E T I ++L Sbjct: 128 EIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSGTFDEQRTATIMEEL 187 Query: 388 VSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYV 567 AL +CH + V HRDIKP+NLL+ G LK+ADFG S HA + RR+ T+CGT Y+ Sbjct: 188 SDALMYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRK----TMCGTLDYL 243 Query: 568 PPEVFARR 591 PPE+ R Sbjct: 244 PPEMIEGR 251
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 148 bits (373), Expect = 1e-35 Identities = 75/188 (39%), Positives = 121/188 (64%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQ 198 +G G +P Y+ + LG+GNFA V LARH TK +VAIK++DK +L +++ Sbjct: 12 TGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN-LEK 70 Query: 199 IKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIF 378 I RE+ +M+ L HPNI++L++VM K +++V E+ + G ++ ++ +NG L E+E R+ F Sbjct: 71 IYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKF 130 Query: 379 QQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTP 558 Q++SA+ +CH + HRD+K +NLL+D + ++K+ADFG + + L T CG+P Sbjct: 131 WQILSAVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGF---GNFYKPGEPLSTWCGSP 187 Query: 559 LYVPPEVF 582 Y PEVF Sbjct: 188 PYAAPEVF 195
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 147 bits (370), Expect = 3e-35 Identities = 74/188 (39%), Positives = 120/188 (63%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQ 198 +G G +P Y+ + LG+GNFA V LARH TK +VAIK++DK +L +++ Sbjct: 12 AGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN-LEK 70 Query: 199 IKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIF 378 I RE+ +M+ L HP+I++L++VM K +++V E+ + G ++ ++ +NG L E+E R+ F Sbjct: 71 IYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKF 130 Query: 379 QQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTP 558 Q++SA+ +CH + HRD+K +NLL+D + ++K+ADFG + L T CG+P Sbjct: 131 WQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEP---LSTWCGSP 187 Query: 559 LYVPPEVF 582 Y PEVF Sbjct: 188 PYAAPEVF 195
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 146 bits (369), Expect = 4e-35 Identities = 75/188 (39%), Positives = 120/188 (63%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQ 198 SG G +P Y+ + LG+GNFA V LARH TK +VAIK++DK +L +++ Sbjct: 12 SGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN-LEK 70 Query: 199 IKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIF 378 I RE+ +M+ L HPNI++L++VM K +++V E+ + G ++ ++ +NG L E+E R+ F Sbjct: 71 IYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKF 130 Query: 379 QQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTP 558 Q++SA+ +CH + HRD+K +NLL+D + ++K+ADFG + + L T G+P Sbjct: 131 WQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGF---GNFYKPGEPLSTCVGSP 187 Query: 559 LYVPPEVF 582 Y PEVF Sbjct: 188 PYAAPEVF 195
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 146 bits (368), Expect = 5e-35 Identities = 72/176 (40%), Positives = 111/176 (63%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG+G F VYLAR ++K +A+KV+ K +L K G Q++RE+ + LRHPN Sbjct: 140 FEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPN 199 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ SR++++++Y GG L+R + + + +QL AL +CH++ V Sbjct: 200 ILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEALLYCHSKKV 259 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+ +G LK+ADFG S HA ++RR T+CGT Y+PPE+ R Sbjct: 260 IHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGR 311
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 145 bits (367), Expect = 7e-35 Identities = 72/176 (40%), Positives = 111/176 (63%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG+G F VYLAR ++K +A+KV+ K +L K G Q++RE+ + LRHPN Sbjct: 140 FEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPN 199 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ SR++++++Y GG L+R + + + +QL AL +CH++ V Sbjct: 200 ILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEALLYCHSKKV 259 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+ +G LK+ADFG S HA ++RR T+CGT Y+PPE+ R Sbjct: 260 IHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGR 311
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 145 bits (367), Expect = 7e-35 Identities = 80/182 (43%), Positives = 116/182 (63%) Frame = +1 Query: 34 MGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREI 213 M D +L YE + +G G FAKV LA H+ T E VAIK+MDK L + ++K EI Sbjct: 1 MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEI 58 Query: 214 AVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVS 393 ++ LRH +I QL+ V+ K++IF+V+EY GG L+ +I + L E+ETR +F+Q++S Sbjct: 59 DALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILS 118 Query: 394 ALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 A+ + H+QG HRD+KP+NLL DE+ LK+ DFGL A ++ L T CG+ Y P Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCA-KPKGNKDYHLQTCCGSLAYAAP 177 Query: 574 EV 579 E+ Sbjct: 178 EL 179
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 145 bits (366), Expect = 9e-35 Identities = 81/182 (44%), Positives = 115/182 (63%) Frame = +1 Query: 34 MGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREI 213 M D +L YE + +G G FAKV LA H+ T E VAIK+MDK L + +IK EI Sbjct: 1 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEI 58 Query: 214 AVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVS 393 ++ LRH +I QL+ V+ ++IF+V+EY GG L+ +I + L E+ETR +F+Q+VS Sbjct: 59 EALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 118 Query: 394 ALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 A+ + H+QG HRD+KP+NLL DE+ LK+ DFGL A ++ L T CG+ Y P Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCA-KPKGNKDYHLQTCCGSLAYAAP 177 Query: 574 EV 579 E+ Sbjct: 178 EL 179
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 145 bits (366), Expect = 9e-35 Identities = 71/172 (41%), Positives = 114/172 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y K LG+G V L H T ++VAIK++++EKL + + +++REIA+++ + HP+ Sbjct: 50 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSE-SVLMKVEREIAILKLIEHPH 108 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +++LH V K +++V+E+V GG L+ ++ G L E R+ F+Q+VSAL FCH+ + Sbjct: 109 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSI 168 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRD+KP+NLL+DE N+++ADFG+ A ++LL T CG+P Y PEV Sbjct: 169 CHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACPEV 217
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 145 bits (365), Expect = 1e-34 Identities = 70/172 (40%), Positives = 114/172 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y K LG+G V L H T ++VAIK++++EKL + + +++REIA+++ + HP+ Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSE-SVLMKVEREIAILKLIEHPH 77 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +++LH V K +++V+E+V GG L+ ++ G L E R+ F+Q++SAL FCH+ + Sbjct: 78 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 137 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRD+KP+NLL+DE N+++ADFG+ A ++LL T CG+P Y PEV Sbjct: 138 CHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACPEV 186
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 144 bits (364), Expect = 1e-34 Identities = 80/217 (36%), Positives = 125/217 (57%), Gaps = 23/217 (10%) Frame = +1 Query: 1 ANARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK 180 + AR R+ + D Y +K +G+GNFAKV LARH+ T EVAIK++DK +L Sbjct: 35 SGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP 94 Query: 181 LGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKED 360 ++Q++ RE+ +M+ L HPNIV+L +V+ + ++++MEY GG ++ ++ A+G +KE Sbjct: 95 T-SLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEK 153 Query: 361 ETRRIFQQ-----------------------LVSALTFCHAQGVYHRDIKPDNLLVDEHG 471 E R F+Q +VSA+ +CH + + HRD+K +NLL+D Sbjct: 154 EARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADM 213 Query: 472 NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 N+K+ADFG S + L T CG+P Y PE+F Sbjct: 214 NIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELF 247
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 144 bits (363), Expect = 2e-34 Identities = 78/195 (40%), Positives = 115/195 (58%), Gaps = 2/195 (1%) Frame = +1 Query: 1 ANARPRSGDGAMGDRPK--LPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKL 174 A PR G K L RYE + LG+G + KV A + VAIK + K+K+ Sbjct: 32 AALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI 91 Query: 175 IKLGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLK 354 + I+REI +M L HP+I+ +++V K +I ++MEY G LY +I L Sbjct: 92 KDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLS 151 Query: 355 EDETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREAL 534 E ETR F+Q+VSA+ +CH GV HRD+K +N+L+D++ N+K+ADFGLS + +++ Sbjct: 152 ERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLS---NLYQKDKF 208 Query: 535 LHTVCGTPLYVPPEV 579 L T CG+PLY PE+ Sbjct: 209 LQTFCGSPLYASPEI 223
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 144 bits (362), Expect = 2e-34 Identities = 78/195 (40%), Positives = 115/195 (58%), Gaps = 2/195 (1%) Frame = +1 Query: 1 ANARPRSGDGAMGDRPK--LPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKL 174 A PR G K L RYE + LG+G + KV A + VAIK + K+K+ Sbjct: 33 APVEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI 92 Query: 175 IKLGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLK 354 + I+REI +M L HP+I+ +++V K +I ++MEY G LY +I L Sbjct: 93 KDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLS 152 Query: 355 EDETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREAL 534 E ETR F+Q+VSA+ +CH GV HRD+K +N+L+D++ N+K+ADFGLS + +++ Sbjct: 153 ERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLS---NLYQKDKF 209 Query: 535 LHTVCGTPLYVPPEV 579 L T CG+PLY PE+ Sbjct: 210 LQTFCGSPLYASPEI 224
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 143 bits (360), Expect = 4e-34 Identities = 72/176 (40%), Positives = 109/176 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG+G F VYLAR +K +A+KV+ K +L K G Q++RE+ + LRHPN Sbjct: 133 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 192 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ +R+++++EY G +YR + E T +L +AL++CH++ V Sbjct: 193 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 252 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+ G LK+ADFG S HA ++RR T+CGT Y+PPE+ R Sbjct: 253 IHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGR 304
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 143 bits (360), Expect = 4e-34 Identities = 71/176 (40%), Positives = 112/176 (63%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG G F +VYLAR + VA+KV+ K ++ K G Q++RE+ + L+H N Sbjct: 16 FEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRN 75 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ +RI++++EY GG LY+ + + L + T I Q+L ALT+CH + V Sbjct: 76 ILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKV 135 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+ +G +K++DFG S H + RR+ T+CGT Y+PPE+ A++ Sbjct: 136 IHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRRK----TMCGTLDYLPPEMIAQK 187
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 143 bits (360), Expect = 4e-34 Identities = 73/173 (42%), Positives = 115/173 (66%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ LG+GNFA V L RH TK EVAIK++DK +L + +++I RE+ +M+ L HP+ Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN-LEKIYREVQIMKMLDHPH 78 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L++VM KS +++V EY + G ++ ++ +G L E E RR F Q++SA+ +CH + + Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 HRD+K +NLL+D + N+K+ADF + + + LL T G+P Y PEVF Sbjct: 139 VHRDLKAENLLLDNNMNIKIADF---SFGNFFKSGELLATWRGSPPYAAPEVF 188
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 142 bits (358), Expect = 7e-34 Identities = 73/176 (41%), Positives = 107/176 (60%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG+G F VYLAR + VA+KV+ K ++ K G Q++REI + L HPN Sbjct: 77 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPN 136 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ + RI++++EY G LY+ + + E T I ++L AL +CH + V Sbjct: 137 ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKV 196 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+ G LK+ADFG S HA + RR+ T+CGT Y+PPE+ R Sbjct: 197 IHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRK----TMCGTLDYLPPEMIEGR 248
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 142 bits (358), Expect = 7e-34 Identities = 71/170 (41%), Positives = 106/170 (62%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG+G F VYLAR +K +A+KV+ K +L K G Q++RE+ + LRHPNI++L+ Sbjct: 132 LGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 191 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 +R+++++EY G +YR + E T +L +AL++CH++ V HRDIK Sbjct: 192 YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIK 251 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+NLL+ +G LK+ADFG S HA ++RR T+CGT Y PPE+ R Sbjct: 252 PENLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYQPPEMIEGR 297
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 142 bits (357), Expect = 9e-34 Identities = 69/170 (40%), Positives = 110/170 (64%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 +G+G F V H+ T +VAIK++++ ++ LG V + + EI +++L HP+I +L + Sbjct: 30 IGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFR 89 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ S IF+VME V GG L+ +I G L E+RR FQQ++S +++CH + HRD+K Sbjct: 90 VISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNHMIVHRDLK 149 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+NLL+D + N+K+ADFGLS + LL T CG+P Y PE+ + + Sbjct: 150 PENLLLDANKNIKIADFGLSNYMTDG---DLLSTACGSPNYAAPELISNK 196
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 142 bits (357), Expect = 9e-34 Identities = 72/176 (40%), Positives = 109/176 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG+G F VYLAR ++ VA+KV+ K ++ K G Q++REI + L+HPN Sbjct: 43 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ R+++++EY G LY+ + + L E T I ++L ALT+CH + V Sbjct: 103 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+ G +K+ADFG S H + RR+ T+CGT Y+PPE+ R Sbjct: 163 IHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK----TMCGTLDYLPPEMIEGR 214
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 141 bits (356), Expect = 1e-33 Identities = 70/170 (41%), Positives = 106/170 (62%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG+G F VYLAR +K +A+KV+ K +L K Q++RE+ + LRHPNI++L+ Sbjct: 130 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYG 189 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 +R+++++EY G +YR + E T +L +AL++CH++ V HRDIK Sbjct: 190 YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIK 249 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+NLL+ +G LK+ADFG S HA ++RR T+CGT Y+PPE+ R Sbjct: 250 PENLLLGSNGELKIADFGWSVHAPSSRRT----TMCGTLDYLPPEMIEGR 295
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 141 bits (355), Expect = 2e-33 Identities = 77/186 (41%), Positives = 114/186 (61%), Gaps = 3/186 (1%) Frame = +1 Query: 37 GDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIA 216 G+ + Y K+LG G FAKV +A H T+ +VAIKV+++ ++ ++ KREI Sbjct: 5 GEHSEALKNYYLGKILGVGTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIK 64 Query: 217 VMRR---LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQL 387 ++R L HP+I+++++V+ IFVVMEY + G L +I L+EDE RR FQQ+ Sbjct: 65 ILRLFIDLIHPHIIRVYEVIVTPKDIFVVMEYCQNGDLLDYILEKRRLQEDEARRTFQQI 124 Query: 388 VSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYV 567 +SA+ +CH V HRD+KP+NLL+D N+K+ADFGLS + L T CG+ Y Sbjct: 125 ISAVEYCHRNKVVHRDLKPENLLLDSKYNVKLADFGLS---NVMHDGHFLKTSCGSLNYA 181 Query: 568 PPEVFA 585 PEV + Sbjct: 182 APEVIS 187
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 140 bits (353), Expect = 3e-33 Identities = 71/166 (42%), Positives = 110/166 (66%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LGEG+F KV LA H T+++VA+K + ++ L K +++REI+ ++ LRHP+I++L+ Sbjct: 40 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 99 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V+ + I +V+EY GG L+ +I + EDE RR FQQ++ A+ +CH + HRD+K Sbjct: 100 VITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLK 158 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 P+NLL+D++ N+K+ADFGLS + L T CG+P Y PEV Sbjct: 159 PENLLLDDNLNVKIADFGLS---NIMTDGNFLKTSCGSPNYAAPEV 201
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 133 bits (334), Expect = 4e-31 Identities = 67/175 (38%), Positives = 109/175 (62%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ V+ LGEG + +V LA + T+E VA+K++D ++ + IK+EI + + L H N Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAAD--CPENIKKEICINKMLNHEN 66 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+ + + ++ +EY GG L+ I + G+ E E +R FQQL++ + + H+ G+ Sbjct: 67 VVKFYGHRREGATQYLFLEYCSGGELFDRIEPDIGMPEPEAQRFFQQLIAGVVYLHSMGI 126 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 HRD+KP+NLL+DE NLK++DFGL+ RE LL+ +CGT YV PE+ R Sbjct: 127 THRDLKPENLLLDERDNLKISDFGLATVFKHNGRERLLNKMCGTLPYVAPELLRR 181
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 132 bits (332), Expect = 7e-31 Identities = 74/171 (43%), Positives = 104/171 (60%), Gaps = 1/171 (0%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAV-QQIKREIAVMRRLRHPNIVQLH 258 LGEG+FAKV H+ T E+VAIKV+DK++ K V + ++RE + + +RHPNI QL Sbjct: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127 Query: 259 KVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 ++ ++ ++VME GG L I L+E E RR +QL+SA+ H GV HRD+ Sbjct: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187 Query: 439 KPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 K +NLL+DE N+K+ DFGLS A T CG+P Y PE+ AR+ Sbjct: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARK 238
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 132 bits (332), Expect = 7e-31 Identities = 74/171 (43%), Positives = 104/171 (60%), Gaps = 1/171 (0%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAV-QQIKREIAVMRRLRHPNIVQLH 258 LGEG+FAKV H+ T E+VAIKV+DK++ K V + ++RE + + +RHPNI QL Sbjct: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127 Query: 259 KVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 ++ ++ ++VME GG L I L+E E RR +QL+SA+ H GV HRD+ Sbjct: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187 Query: 439 KPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 K +NLL+DE N+K+ DFGLS A T CG+P Y PE+ AR+ Sbjct: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARK 238
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 131 bits (329), Expect = 2e-30 Identities = 67/176 (38%), Positives = 109/176 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ V+ LGEG + +V LA + T+E VA+K++D ++ + + IK+EI + + L H N Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD--CPENIKKEICINKMLNHEN 66 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+ + + ++ +EY GG L+ I + G+ E + +R F QL++ + + H G+ Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+DE NLK++DFGL+ RE LL+ +CGT YV PE+ RR Sbjct: 127 THRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 130 bits (328), Expect = 2e-30 Identities = 74/171 (43%), Positives = 103/171 (60%), Gaps = 1/171 (0%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAV-QQIKREIAVMRRLRHPNIVQLH 258 LGEG+FAKV H+ T E+VAIKV+DK++ K V + ++RE + + +RHPNI QL Sbjct: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127 Query: 259 KVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 ++ ++ ++VME GG L I L E E RR +QL+SA+ H GV HRD+ Sbjct: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDL 187 Query: 439 KPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 K +NLL+DE N+K+ DFGLS A T CG+P Y PE+ AR+ Sbjct: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARK 238
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 130 bits (328), Expect = 2e-30 Identities = 67/176 (38%), Positives = 109/176 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ V+ LGEG + +V LA + T+E VA+K++D ++ I + IK+EI + + L H N Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAID--CPENIKKEICINKMLNHEN 66 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+ + + ++ +EY GG L+ I + G+ E + +R F QL++ + + H G+ Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGI 126 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+DE NLK++DFGL+ RE LL+ +CGT YV PE+ R+ Sbjct: 127 THRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRK 182
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 130 bits (328), Expect = 2e-30 Identities = 68/178 (38%), Positives = 105/178 (58%), Gaps = 4/178 (2%) Frame = +1 Query: 58 ARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLG----AVQQIKREIAVMR 225 + YE ++ LG G FA V LA +++ + AIK+++K K++ A + +REI +++ Sbjct: 165 SHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILK 224 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 L HP +VQ H++ +F+VMEYV GG L + ANG + E + + + +QL+ L Sbjct: 225 SLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLH 284 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 H QGV HRDIKP+N+L+ +LK++DFGL+ L T CGT Y+ PEV Sbjct: 285 LHKQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGT--GTFLETFCGTMGYLAPEV 340
>SAPK2_ORYSA (Q84TC6) Serine/threonine-protein kinase SAPK2 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 2) Length = 339 Score = 130 bits (327), Expect = 3e-30 Identities = 73/183 (39%), Positives = 107/183 (58%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE +K +G GNF L R + TKE A+K +++ + I + ++REI R LRHP Sbjct: 3 RYEVIKDIGSGNFGVAKLVRDVRTKELFAVKFIERGQKID----ENVQREIMNHRSLRHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV+ +V+ + + +VMEY GG L+ I + G EDE R FQQL+S +++CH+ Sbjct: 59 NIVRFKEVVLTPTHLAIVMEYAAGGELFERICSAGRFSEDEARFFFQQLISGVSYCHSMQ 118 Query: 421 VYHRDIKPDNLLVDEH--GNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D LK+ DFG S + +LLH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENTLLDGSIAPRLKICDFGYS-------KSSLLHSQPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 AR+ Sbjct: 172 ARK 174
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 129 bits (325), Expect = 5e-30 Identities = 67/176 (38%), Positives = 108/176 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ V+ LGEG + +V LA + T+E VA+K++D ++ I + IK+EI + + L H N Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAID--CPENIKKEICINKMLSHEN 66 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+ + ++ +EY GG L+ I + G+ E + +R F QL++ + + H G+ Sbjct: 67 VVKFYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGI 126 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+DE NLK++DFGL+ RE LL+ +CGT YV PE+ R+ Sbjct: 127 THRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRK 182
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 129 bits (323), Expect = 8e-30 Identities = 67/176 (38%), Positives = 108/176 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ V+ LGEG + +V LA + T+E VA+K++D + + IK+EI + R L H N Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTRAAD--CPENIKKEICINRMLSHTN 66 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV+ + + ++ +EY RGG L+ I + G+ E + ++ FQQL++ + + H+ G+ Sbjct: 67 IVRFYGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGI 126 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+NLL+DE LK++DFGL+ +E LL+ +CGT YV PE+ R Sbjct: 127 THRDIKPENLLLDERDQLKISDFGLATVFRHNGKERLLNKMCGTLPYVAPELIKSR 182
>SAPK3_ORYSA (Q75V63) Serine/threonine-protein kinase SAPK3 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 3) (Protein kinase REK) Length = 334 Score = 129 bits (323), Expect = 8e-30 Identities = 73/183 (39%), Positives = 105/183 (57%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE +K LG GNF L R +KE VA+K +++ K I + ++REI R LRHP Sbjct: 4 RYEALKELGAGNFGVARLVRDKRSKELVAVKYIERGKKID----ENVQREIINHRSLRHP 59 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V + + +VMEY GG L+ I G EDE R FQQL+S +++CH+ Sbjct: 60 NIIRFKEVCLTPTHLAIVMEYAAGGELFEQICTAGRFSEDEARYFFQQLISGVSYCHSLE 119 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D +K+ DFG S + ALLH + GTP Y+ PEV Sbjct: 120 ICHRDLKLENTLLDGSPTPRVKICDFGYS-------KSALLHSKPKSTVGTPAYIAPEVL 172 Query: 583 ARR 591 +R+ Sbjct: 173 SRK 175
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 128 bits (322), Expect = 1e-29 Identities = 66/185 (35%), Positives = 107/185 (57%), Gaps = 3/185 (1%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P++ A+Y+ L+G GNF+KV H TK+ AIK++D+ + + + E+AV+R Sbjct: 74 PRVTAKYDIKALIGRGNFSKVVRVEHRVTKQPYAIKMIDRVQ-----GKEVFESEVAVLR 128 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 R++H I+QL +V K ++++VME GG L+ I A G E + R+ ++ + + Sbjct: 129 RVKHSYIIQLIEVFETKDKVYMVMELATGGELFDRIIAKGSFTERDATRVLNMVLDGVKY 188 Query: 406 CHAQGVYHRDIKPDNLLVDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 H G+ HRD+KP+NLL G+ + + DFGLS + E + T CGTP Y+ PE Sbjct: 189 LHGLGITHRDLKPENLLYYHPGHDSKIMITDFGLS--STRKGPENFMRTTCGTPEYIAPE 246 Query: 577 VFARR 591 + AR+ Sbjct: 247 IIARK 251
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 128 bits (321), Expect = 1e-29 Identities = 69/202 (34%), Positives = 112/202 (55%), Gaps = 7/202 (3%) Frame = +1 Query: 7 ARPRSGDGAMGD-------RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDK 165 A PR G G++ R K P ++ K+LGEG+F+ V LAR + T E AIK+++K Sbjct: 56 AEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEK 115 Query: 166 EKLIKLGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANG 345 +IK V + RE VM RL HP V+L+ +++ + Y + G L ++I G Sbjct: 116 RHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIG 175 Query: 346 GLKEDETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARR 525 E TR ++VSAL + H +G+ HRD+KP+N+L++E ++++ DFG + + Sbjct: 176 SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESK 235 Query: 526 EALLHTVCGTPLYVPPEVFARR 591 +A ++ GT YV PE+ + Sbjct: 236 QARANSFVGTAQYVSPELLTEK 257
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 127 bits (320), Expect = 2e-29 Identities = 65/172 (37%), Positives = 106/172 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E K LG+G F +VYLA+ T VA+K + K +L++ +Q++REI + LRH N Sbjct: 89 FEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN 148 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ + RI++++E+ G LY+H+ E+ + Q+ +AL++ H + V Sbjct: 149 ILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKHV 208 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRDIKP+N+L+ G +K++DFG S HA + RR T+CGT Y+PPE+ Sbjct: 209 IHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRT----TLCGTLDYLPPEM 256
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 126 bits (317), Expect = 4e-29 Identities = 68/181 (37%), Positives = 105/181 (58%), Gaps = 15/181 (8%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQ---------------IKREIA 216 LG G+ KV LAR+ T +E A+KV+ K + G V I+REI Sbjct: 25 LGLGSTGKVQLARNGSTGQEAAVKVISKA-VFNTGNVSGTSIVGSTTPDALPYGIEREII 83 Query: 217 VMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSA 396 +M+ L HPN+++L+ V + +++V+EY G L+ + G L E E R F+Q++ Sbjct: 84 IMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIG 143 Query: 397 LTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 +++CHA G+ HRD+KP+NLL+D N+K+ADFG++A + LL T CG+P Y PE Sbjct: 144 VSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGK---LLETSCGSPHYAAPE 200 Query: 577 V 579 + Sbjct: 201 I 201
>SAPK5_ORYSA (Q7XKA8) Serine/threonine-protein kinase SAPK5 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 5) Length = 370 Score = 126 bits (316), Expect = 5e-29 Identities = 72/183 (39%), Positives = 104/183 (56%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE V+ +G GNF L R+ +T+E VA+K +++ I + + REI R LRHP Sbjct: 3 KYEPVREIGAGNFGVAKLMRNKETRELVAMKFIERGNRID----ENVFREIVNHRSLRHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + +VMEY GG L+ I G EDE R FQQLV +++CHA Sbjct: 59 NIIRFKEVVVTGRHLAIVMEYAAGGELFERICEAGRFHEDEARYFFQQLVCGVSYCHAMQ 118 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D LK+ DFG S + +LLH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSLLHSRPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 +RR Sbjct: 172 SRR 174
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 126 bits (316), Expect = 5e-29 Identities = 75/197 (38%), Positives = 114/197 (57%), Gaps = 8/197 (4%) Frame = +1 Query: 19 SGDGAMGDR----PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLG 186 S +G G+R L +Y+ K++G+GNFA V T +E A+K++DK K G Sbjct: 375 SPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCC--G 432 Query: 187 AVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 I+ E++++RR++HPNI+ L + M + +F+VME V+GG L+ I ++ E + Sbjct: 433 KEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDG 492 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEH----GNLKVADFGLSAHADTARREAL 534 + L +AL + H + HRDIKP+NLLV E+ +LK+ DFGL+ E Sbjct: 493 SAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV-----EGP 547 Query: 535 LHTVCGTPLYVPPEVFA 585 L+TVCGTP YV PE+ A Sbjct: 548 LYTVCGTPTYVAPEIIA 564
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 126 bits (316), Expect = 5e-29 Identities = 61/172 (35%), Positives = 107/172 (62%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +K++G+G F KVY R DT E A+KVM K+K+++ + +K E ++ ++ HP Sbjct: 140 FEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPF 199 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IVQL K R+++V++++ GG L+ + G +ED R ++VSA++ H +G+ Sbjct: 200 IVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGI 259 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRD+KP+N+L+D G++ + DFGL+ + R +++CGT Y+ PE+ Sbjct: 260 MHRDLKPENILMDVDGHVMLTDFGLAKEFEENTRS---NSMCGTTEYMAPEI 308
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 125 bits (315), Expect = 7e-29 Identities = 70/179 (39%), Positives = 104/179 (58%), Gaps = 4/179 (2%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RY+ + +G+GNFA V T E A+K++ K K G I+ E++++RR++HP Sbjct: 405 RYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKC--RGKEHMIQNEVSILRRVKHP 462 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV L + M + +++VME V+GG L+ I + E + + L SA+ + H+ Sbjct: 463 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLN 522 Query: 421 VYHRDIKPDNLLVDEH----GNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 + HRDIKP+NLLV EH +LK+ DFGL+ D L+TVCGTP YV PE+ A Sbjct: 523 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-----GPLYTVCGTPTYVAPEIIA 576
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 125 bits (315), Expect = 7e-29 Identities = 70/179 (39%), Positives = 104/179 (58%), Gaps = 4/179 (2%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RY+ + +G+GNFA V T E A+K++ K K G I+ E++++RR++HP Sbjct: 389 RYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKC--RGKEHMIQNEVSILRRVKHP 446 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV L + M + +++VME V+GG L+ I + E + + L SA+ + H+ Sbjct: 447 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 506 Query: 421 VYHRDIKPDNLLVDEH----GNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 + HRDIKP+NLLV EH +LK+ DFGL+ D L+TVCGTP YV PE+ A Sbjct: 507 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-----GPLYTVCGTPTYVAPEIIA 560
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 125 bits (315), Expect = 7e-29 Identities = 70/179 (39%), Positives = 104/179 (58%), Gaps = 4/179 (2%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RY+ + +G+GNFA V T E A+K++ K K G I+ E++++RR++HP Sbjct: 82 RYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKC--RGKEHMIQNEVSILRRVKHP 139 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV L + M + +++VME V+GG L+ I + E + + L SA+ + H+ Sbjct: 140 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLN 199 Query: 421 VYHRDIKPDNLLVDEH----GNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 + HRDIKP+NLLV EH +LK+ DFGL+ D L+TVCGTP YV PE+ A Sbjct: 200 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-----GPLYTVCGTPTYVAPEIIA 253
>KAPCA_BOVIN (P00517) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 125 bits (315), Expect = 7e-29 Identities = 59/173 (34%), Positives = 103/173 (59%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E++K LG G+F +V L +HM+T A+K++DK+K++KL ++ E +++ + P Sbjct: 42 QFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 101 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ Sbjct: 102 FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 161 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 162 LIYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPC_DROME (P12370) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 352 Score = 125 bits (314), Expect = 9e-29 Identities = 61/172 (35%), Positives = 102/172 (59%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E++K LG G+F +V + +H TK+ A+K++DK+K++KL V+ E +++ ++ P Sbjct: 45 FERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPF 104 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V L S +++V+EYV GG ++ H+ G E +R Q+V A + H + Sbjct: 105 LVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDL 164 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G LKV DFG + R + T+CGTP Y+ PE+ Sbjct: 165 IYRDLKPENLLIDSQGYLKVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 211
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 125 bits (314), Expect = 9e-29 Identities = 64/183 (34%), Positives = 105/183 (57%) Frame = +1 Query: 43 RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM 222 R K P ++ K+LGEG+F+ V LAR + T E AIK+++K +IK V + RE VM Sbjct: 78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 137 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 RL HP V+L+ +++ + Y + G L ++I G E TR ++VSAL Sbjct: 138 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 197 Query: 403 FCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 + H +G+ HRD+KP+N+L++E ++++ DFG + ++A ++ GT YV PE+ Sbjct: 198 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 257 Query: 583 ARR 591 + Sbjct: 258 TEK 260
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 125 bits (313), Expect = 1e-28 Identities = 65/174 (37%), Positives = 100/174 (57%), Gaps = 8/174 (4%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLG--------AVQQIKREIAVMRRLRH 237 LG G+ KV LA+H T A+KV+ K G I+REI +M+ L H Sbjct: 27 LGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSH 86 Query: 238 PNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ 417 PN++ L+ V + +++++EY G L+ + +G L E E F+Q++ +++CHA Sbjct: 87 PNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHAL 146 Query: 418 GVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 G+ HRD+KP+NLL+D N+K+ADFG++A A LL T CG+P Y PE+ Sbjct: 147 GIVHRDLKPENLLLDSFYNIKIADFGMAALQTDA---DLLETSCGSPHYAAPEI 197
>ASK1_ARATH (P43291) Serine/threonine-protein kinase ASK1 (EC 2.7.11.1)| Length = 363 Score = 125 bits (313), Expect = 1e-28 Identities = 71/183 (38%), Positives = 105/183 (57%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE VK +G GNF L + ++KE VA+K +++ I + + REI R LRHP Sbjct: 3 KYELVKDIGAGNFGVARLMKVKNSKELVAMKYIERGPKID----ENVAREIINHRSLRHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + + MEY GG L+ I + G EDE R FQQL+S +++CHA Sbjct: 59 NIIRFKEVVLTPTHLAIAMEYAAGGELFERICSAGRFSEDEARYFFQQLISGVSYCHAMQ 118 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D LK+ DFG S + +LLH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSLLHSRPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 +RR Sbjct: 172 SRR 174
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 125 bits (313), Expect = 1e-28 Identities = 68/179 (37%), Positives = 115/179 (64%), Gaps = 2/179 (1%) Frame = +1 Query: 49 KLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRR 228 K+ Y+ K LG G+FA V LARH+ T E+VA+KV+DK KL L A + +E+ M+ Sbjct: 11 KIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQEVRCMKL 69 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPAN-GGLKEDETRRIFQQLVSALTF 405 ++HPNIV+L++V+ ++++++++E GG ++ +I + GL ED ++ F Q+V A+++ Sbjct: 70 VQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129 Query: 406 CHAQGVYHRDIKPDNLL-VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 CH V HRD+KP+N++ ++ G +K+ DFG S ++ L T CG+ Y PE+ Sbjct: 130 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK---LTTSCGSLAYSAPEI 185
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 125 bits (313), Expect = 1e-28 Identities = 68/179 (37%), Positives = 115/179 (64%), Gaps = 2/179 (1%) Frame = +1 Query: 49 KLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRR 228 K+ Y+ K LG G+FA V LARH+ T E+VA+KV+DK KL L A + +E+ M+ Sbjct: 11 KIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQEVRCMKL 69 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPAN-GGLKEDETRRIFQQLVSALTF 405 ++HPNIV+L++V+ ++++++++E GG ++ +I + GL ED ++ F Q+V A+++ Sbjct: 70 VQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129 Query: 406 CHAQGVYHRDIKPDNLL-VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 CH V HRD+KP+N++ ++ G +K+ DFG S ++ L T CG+ Y PE+ Sbjct: 130 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK---LTTSCGSLAYSAPEI 185
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 125 bits (313), Expect = 1e-28 Identities = 68/172 (39%), Positives = 99/172 (57%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +K+LG+G F KV L R T + AIK++ KE +I+ V E V++ HP Sbjct: 266 FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPF 325 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 ++ L R+ VM+YV GG L+ H+ ED TR +++SAL + H+QG+ Sbjct: 326 LISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGI 385 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K +NLL+D+ G++KVADFGL T R T CGTP Y+ PEV Sbjct: 386 IYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTT--KTFCGTPEYLAPEV 435
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 125 bits (313), Expect = 1e-28 Identities = 67/185 (36%), Positives = 109/185 (58%), Gaps = 3/185 (1%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P++ A+Y+ L+G G+F++V H T++ AIK+++ + + G + + E+ V+R Sbjct: 91 PRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETK--YREGR-EVCESELRVLR 147 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 R+RH NI+QL +V + R+++VME GG L+ I A G E + R+ Q ++ + + Sbjct: 148 RVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRY 207 Query: 406 CHAQGVYHRDIKPDNLLVDEHG---NLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 HA G+ HRD+KP+NLL G + + DFGL A A + L+ T CGTP Y+ PE Sbjct: 208 LHALGITHRDLKPENLLYYHPGTDSKIIITDFGL-ASARKKGDDCLMKTTCGTPEYIAPE 266 Query: 577 VFARR 591 V R+ Sbjct: 267 VLVRK 271
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 125 bits (313), Expect = 1e-28 Identities = 67/185 (36%), Positives = 109/185 (58%), Gaps = 3/185 (1%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P++ A+Y+ L+G G+F++V H T++ AIK+++ + + G + + E+ V+R Sbjct: 91 PRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETK--YREGR-EVCESELRVLR 147 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 R+RH NI+QL +V + R+++VME GG L+ I A G E + R+ Q ++ + + Sbjct: 148 RVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRY 207 Query: 406 CHAQGVYHRDIKPDNLLVDEHG---NLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 HA G+ HRD+KP+NLL G + + DFGL A A + L+ T CGTP Y+ PE Sbjct: 208 LHALGITHRDLKPENLLYYHPGTDSKIIITDFGL-ASARKKGDDCLMKTTCGTPEYIAPE 266 Query: 577 VFARR 591 V R+ Sbjct: 267 VLVRK 271
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 125 bits (313), Expect = 1e-28 Identities = 68/179 (37%), Positives = 115/179 (64%), Gaps = 2/179 (1%) Frame = +1 Query: 49 KLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRR 228 K+ Y+ K LG G+FA V LARH+ T E+VA+KV+DK KL L A + +E+ M+ Sbjct: 11 KIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQEVRCMKL 69 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPAN-GGLKEDETRRIFQQLVSALTF 405 ++HPNIV+L++V+ ++++++++E GG ++ +I + GL ED ++ F Q+V A+++ Sbjct: 70 VQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129 Query: 406 CHAQGVYHRDIKPDNLL-VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 CH V HRD+KP+N++ ++ G +K+ DFG S ++ L T CG+ Y PE+ Sbjct: 130 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK---LTTSCGSLAYSAPEI 185
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 125 bits (313), Expect = 1e-28 Identities = 64/183 (34%), Positives = 105/183 (57%) Frame = +1 Query: 43 RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM 222 R K P ++ K+LGEG+F+ V LAR + T E AIK+++K +IK V + RE VM Sbjct: 78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 137 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 RL HP V+L+ +++ + Y + G L ++I G E TR ++VSAL Sbjct: 138 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 197 Query: 403 FCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 + H +G+ HRD+KP+N+L++E ++++ DFG + ++A ++ GT YV PE+ Sbjct: 198 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPDSKQARANSFVGTAQYVSPELL 257 Query: 583 ARR 591 + Sbjct: 258 TEK 260
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 124 bits (312), Expect = 2e-28 Identities = 63/176 (35%), Positives = 101/176 (57%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E K LG+G F KVYL + T A+K M+K++L++ +Q +RE+ + LRH N Sbjct: 99 FEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTN 158 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +++L K R+++++EYV G LY+ + E Q+ AL + H + + Sbjct: 159 VLRLFGHFHDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALLYLHGKNI 218 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+N+L+ + +K++DFG S HA + RR T+CGT Y+PPE+ R Sbjct: 219 IHRDIKPENILLHFNDTIKISDFGWSVHAPSNRRS----TLCGTMDYLPPEIVQSR 270
>ASK2_ARATH (P43292) Serine/threonine-protein kinase ASK2 (EC 2.7.11.1)| Length = 353 Score = 124 bits (312), Expect = 2e-28 Identities = 71/183 (38%), Positives = 104/183 (56%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +Y+ VK LG GNF L RH DTKE VA+K +++ + I + + REI R L+HP Sbjct: 3 KYDVVKDLGAGNFGVARLLRHKDTKELVAMKYIERGRKID----ENVAREIINHRSLKHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I G E E R FQQL+ + +CH+ Sbjct: 59 NIIRFKEVILTPTHLAIVMEYASGGELFDRICTAGRFSEAEARYFFQQLICGVDYCHSLQ 118 Query: 421 VYHRDIKPDNLLVDEHGN--LKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D LK+ DFG S + ++LH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENTLLDGSPAPLLKICDFGYS-------KSSILHSRPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 +RR Sbjct: 172 SRR 174
>SAPK9_ORYSA (Q75V57) Serine/threonine-protein kinase SAPK9 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 9) Length = 361 Score = 124 bits (312), Expect = 2e-28 Identities = 70/183 (38%), Positives = 106/183 (57%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE VK +G GNF L R+ + + VA+K +D+ + I + ++REI R LRHP Sbjct: 21 RYELVKEIGSGNFGVARLMRNRASGDLVAVKYIDRGEKID----ENVQREIINHRSLRHP 76 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I + G EDE R FQQL+S +++CH+ Sbjct: 77 NIIRFKEVILTPTHLAIVMEYASGGELFERICSAGRFSEDEARFFFQQLISGVSYCHSMQ 136 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 V HRD+K +N L+D LK+ DFG S + ++LH + GTP Y+ PEV Sbjct: 137 VCHRDLKLENTLLDGSTAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVL 189 Query: 583 ARR 591 ++ Sbjct: 190 LKK 192
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 124 bits (312), Expect = 2e-28 Identities = 59/176 (33%), Positives = 104/176 (59%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E K+LG+G F KVY +H +T A+K M+K+++++ +Q +RE+ + +H N Sbjct: 100 FEIGKILGKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGSFKHKN 159 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + QL+ + R++++MEYV G LY+ + NG L E Q+ +AL + H++ + Sbjct: 160 LTQLYGFFYDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVYQMANALDYMHSKNI 219 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+N+L+ + +K+ DFG S + + ++ T+CGT Y+ PE+ R Sbjct: 220 LHRDIKPENILIGFNNTIKLTDFGWSVYNEDGQKR---KTLCGTIDYLSPELIKSR 272
>SAPK6_ORYSA (Q6ZI44) Serine/threonine-protein kinase SAPK6 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 6) Length = 365 Score = 124 bits (311), Expect = 2e-28 Identities = 71/183 (38%), Positives = 105/183 (57%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE +K +G GNF L R+ +TKE VA+K + + I + + REI R LRHP Sbjct: 3 KYELLKDIGSGNFGVARLMRNRETKELVAMKYIPRGLKID----ENVAREIINHRSLRHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I + G EDE+R FQQL+ +++CH Sbjct: 59 NIIRFKEVVLTPTHLAIVMEYAAGGELFDRICSAGRFSEDESRYFFQQLICGVSYCHFMQ 118 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D LK+ DFG S + +LLH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSLLHSKPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 +RR Sbjct: 172 SRR 174
>MAST3_HUMAN (O60307) Microtubule-associated serine/threonine-protein kinase 3| (EC 2.7.11.1) Length = 1309 Score = 124 bits (311), Expect = 2e-28 Identities = 68/189 (35%), Positives = 100/189 (52%), Gaps = 13/189 (6%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +KL+ G + VYL RH DT++ AIK ++K+ LI +QQ+ E ++ +P Sbjct: 367 FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF 426 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V + + + +VMEYV GG + G L D R F + V AL + H G+ Sbjct: 427 VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI 486 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLS-------------AHADTARREALLHTVCGTPLY 564 HRD+KPDNLL+ G++K+ DFGLS H + RE + VCGTP Y Sbjct: 487 VHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEY 546 Query: 565 VPPEVFARR 591 + PEV R+ Sbjct: 547 IAPEVIFRQ 555
>KAPCG_MACMU (O62846) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) (Fragment) Length = 208 Score = 124 bits (311), Expect = 2e-28 Identities = 60/173 (34%), Positives = 103/173 (59%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E++K LG G++ +V L RH +T A+K++DK+K+++L V+ E +++ + P Sbjct: 41 QFERLKTLGTGSYGRVMLVRHRETGNHYAMKILDKQKVVRLKQVEHTLNEKRILQAINFP 100 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E + Q+V A + H+ Sbjct: 101 FLVKLQFSFKDNSNLYLVMEYVPGGEMFSHLRRVGRFSEPQACFYAAQVVLAFQYLHSLD 160 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + HRD+KP+NLL+D+ G L+V DFG + R + T+CGTP Y+ PE+ Sbjct: 161 LIHRDLKPENLLIDQQGYLQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 208
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 124 bits (310), Expect = 3e-28 Identities = 75/197 (38%), Positives = 114/197 (57%), Gaps = 8/197 (4%) Frame = +1 Query: 19 SGDGAMGDRPK----LPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLG 186 S +G G+R L +Y K++G+GNFA V T +E A+K++DK K G Sbjct: 374 SPEGVNGNRCSESFPLLEKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCC--G 431 Query: 187 AVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 I+ E++++RR++HPNI+ L + M + +F+VME V+GG L+ I ++ E + Sbjct: 432 KEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDG 491 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEH----GNLKVADFGLSAHADTARREAL 534 + L +AL + H+ + HRDIKP+NLLV E+ +LK+ DFGL+ E Sbjct: 492 SAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV-----EGP 546 Query: 535 LHTVCGTPLYVPPEVFA 585 L+TVCGTP YV PE+ A Sbjct: 547 LYTVCGTPTYVAPEIIA 563
>SAPK7_ORYSA (Q7XQP4) Serine/threonine-protein kinase SAPK7 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 7) Length = 359 Score = 124 bits (310), Expect = 3e-28 Identities = 72/183 (39%), Positives = 103/183 (56%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE +K +G GNF L R+ +TKE VA+K + + I + + REI R LRHP Sbjct: 3 RYELLKDIGAGNFGVARLMRNKETKELVAMKYIPRGLKID----ENVAREIINHRSLRHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I G EDE R FQQL+ +++CH Sbjct: 59 NIIRFKEVVVTPTHLAIVMEYAAGGELFDRICNAGRFSEDEARYFFQQLICGVSYCHFMQ 118 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N L+D LK+ DFG S + +LLH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSLLHSKPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 +RR Sbjct: 172 SRR 174
>KAPCA_PIG (P36887) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 124 bits (310), Expect = 3e-28 Identities = 58/173 (33%), Positives = 102/173 (58%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E++K LG G+F +V L +H +T A+K++DK+K++KL ++ E +++ + P Sbjct: 42 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 101 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ Sbjct: 102 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 161 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 162 LIYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>ST32A_MOUSE (Q8BGW6) Serine/threonine-protein kinase 32A (EC 2.7.11.1)| Length = 398 Score = 123 bits (309), Expect = 3e-28 Identities = 61/176 (34%), Positives = 106/176 (60%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E ++ +G+G+F KV + R DTK+ A+K M+K+K ++ V+ + +E+ +M+ L HP Sbjct: 23 FEILRAIGKGSFGKVCIVRKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 82 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V L + +F+V++ + GG L H+ N +ED + +L AL + +Q + Sbjct: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFQEDTVKLFICELAMALDYLQSQRI 142 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KPDN+L+DEHG++ + DF ++A +E + TV GT Y+ PE+F R Sbjct: 143 IHRDMKPDNILLDEHGHVHITDFNIAA---MLPKETRITTVAGTKPYMAPEMFTSR 195
>SAPK4_ORYSA (Q5N942) Serine/threonine-protein kinase SAPK4 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 4) Length = 360 Score = 123 bits (309), Expect = 3e-28 Identities = 68/183 (37%), Positives = 105/183 (57%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +YE V+ +G GNF L R+ +T+E VA+K +++ I + + REI R LRHP Sbjct: 3 KYEAVRDIGSGNFGVARLMRNRETRELVAVKCIERGHRID----ENVYREIINHRSLRHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VME+ GG L+ I G EDE R FQQL+ +++CH Sbjct: 59 NIIRFKEVILTPTHLMIVMEFAAGGELFDRICDRGRFSEDEARYFFQQLICGVSYCHHMQ 118 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 + HRD+K +N+L+D LK+ DFG S + ++LH + GTP Y+ PEV Sbjct: 119 ICHRDLKLENVLLDGSPAPRLKICDFGYS-------KSSVLHSRPKSAVGTPAYIAPEVL 171 Query: 583 ARR 591 +RR Sbjct: 172 SRR 174
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 123 bits (309), Expect = 3e-28 Identities = 66/187 (35%), Positives = 107/187 (57%), Gaps = 5/187 (2%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P++ A+Y+ L+G G+F++V H T++ AIK++ E + G + + E+ V+R Sbjct: 90 PRVTAKYDIKALIGRGSFSRVVRVEHRSTRQPYAIKMI--ETRYREGR-EVCESELCVLR 146 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 R+RH NI+QL +V R+++VME GG L+ I G E + R+ Q ++ + + Sbjct: 147 RVRHTNIIQLMEVFETAERVYMVMELATGGELFDRIITRGSFTERDATRVLQMVLDGVKY 206 Query: 406 CHAQGVYHRDIKPDNLLVDEHG---NLKVADFGLSAHADTARR--EALLHTVCGTPLYVP 570 H G+ HRD+KP+NLL G + + DFGL A T ++ E L+ T CGTP Y+ Sbjct: 207 LHTLGITHRDLKPENLLYYHPGADSKIMITDFGL---ASTRKKGDECLMKTTCGTPEYIA 263 Query: 571 PEVFARR 591 PE+ R+ Sbjct: 264 PEILVRK 270
>KAPCA_CANFA (Q8MJ44) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 349 Score = 123 bits (309), Expect = 3e-28 Identities = 58/173 (33%), Positives = 102/173 (58%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E++K LG G+F +V L +H +T A+K++DK+K++KL ++ E +++ + P Sbjct: 41 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 100 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ Sbjct: 101 FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 160 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 161 LIYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 208
>MAST2_HUMAN (Q6P0Q8) Microtubule-associated serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 1798 Score = 123 bits (309), Expect = 3e-28 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 20/213 (9%) Frame = +1 Query: 13 PRSGDGAMGDRPKLPAR-------YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEK 171 P + D G LP++ +E +KL+ G + V+L RH T++ A+K ++K+ Sbjct: 488 PETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQN 547 Query: 172 LIKLGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGL 351 LI +QQ E ++ +P +V + K + +VMEYV GG + G L Sbjct: 548 LILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGAL 607 Query: 352 KEDETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLS---------- 501 D R F + V AL + H G+ HRD+KPDNLL+ G++K+ DFGLS Sbjct: 608 PVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTN 667 Query: 502 ---AHADTARREALLHTVCGTPLYVPPEVFARR 591 H + RE L VCGTP Y+ PEV R+ Sbjct: 668 LYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQ 700
>KAPCA_SHEEP (Q9MZD9) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 123 bits (309), Expect = 3e-28 Identities = 58/173 (33%), Positives = 102/173 (58%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E++K LG G+F +V L +H +T A+K++DK+K++KL ++ E +++ + P Sbjct: 42 QFERIKTLGTGSFGRVMLVKHTETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 101 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ Sbjct: 102 FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 161 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 162 LIYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPCA_HUMAN (P17612) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 123 bits (309), Expect = 3e-28 Identities = 58/173 (33%), Positives = 102/173 (58%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E++K LG G+F +V L +H +T A+K++DK+K++KL ++ E +++ + P Sbjct: 42 QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 101 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ Sbjct: 102 FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 161 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 162 LIYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 122 bits (307), Expect = 6e-28 Identities = 59/171 (34%), Positives = 104/171 (60%), Gaps = 1/171 (0%) Frame = +1 Query: 79 LLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLH 258 LLG+G+FA VY A + T EVAIK++DK+ + K G VQ+++ E+ + +L+HP+I++L+ Sbjct: 17 LLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELY 76 Query: 259 KVMACKSRIFVVMEYVRGGPLYRHIPAN-GGLKEDETRRIFQQLVSALTFCHAQGVYHRD 435 + +++V+E G + R++ E+E R Q+++ + + H+ G+ HRD Sbjct: 77 NYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRD 136 Query: 436 IKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 + NLL+ + N+K+ADFGL+ + +T+CGTP Y+ PE+ R Sbjct: 137 LTLSNLLLTRNMNIKIADFGLATQLKMPHEKH--YTLCGTPNYISPEIATR 185
>ST32A_HUMAN (Q8WU08) Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1)| Length = 396 Score = 122 bits (307), Expect = 6e-28 Identities = 61/176 (34%), Positives = 107/176 (60%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E ++ +G+G+F KV + + DTK+ A+K M+K+K ++ V+ + +E+ +M+ L HP Sbjct: 23 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 82 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V L + +F+V++ + GG L H+ N KE+ + +LV AL + Q + Sbjct: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRI 142 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KPDN+L+DEHG++ + DF ++A RE + T+ GT Y+ PE+F+ R Sbjct: 143 IHRDMKPDNILLDEHGHVHITDFNIAA---MLPRETQITTMAGTKPYMAPEMFSSR 195
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 122 bits (306), Expect = 8e-28 Identities = 58/178 (32%), Positives = 100/178 (56%) Frame = +1 Query: 58 ARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRH 237 A +E K+LG+G F +VY RH+++ A+K M+K+ +I+ +Q +RE+ + LRH Sbjct: 107 ADFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRH 166 Query: 238 PNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ 417 PN+ QL+ + R++++MEY+ G LY+H+ + Q+ AL + H + Sbjct: 167 PNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHER 226 Query: 418 GVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 + HRDIKP+N+++ + +K+ DFG S + T+CGT Y+ PE+ R Sbjct: 227 NILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSKR---KTLCGTVDYLSPELIRSR 281
>MAST2_MOUSE (Q60592) Microtubule-associated serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 1734 Score = 122 bits (305), Expect = 1e-27 Identities = 71/205 (34%), Positives = 103/205 (50%), Gaps = 15/205 (7%) Frame = +1 Query: 22 GDGAMGDRPKLPAR--YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQ 195 G G K P+ +E +KL+ G + V+L RH T++ A+K ++K+ LI +Q Sbjct: 437 GRGVSQPSQKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQ 496 Query: 196 QIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRI 375 Q E ++ +P +V + K + +VMEYV GG + G L D R Sbjct: 497 QAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLY 556 Query: 376 FQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLS-------------AHADT 516 F + V AL + H G+ HRD+KPDNLL+ G++K+ DFGLS H + Sbjct: 557 FAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEK 616 Query: 517 ARREALLHTVCGTPLYVPPEVFARR 591 RE L VCGTP Y+ PEV R+ Sbjct: 617 DAREFLDKQVCGTPEYIAPEVILRQ 641
>KAPCA_CRIGR (P25321) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 122 bits (305), Expect = 1e-27 Identities = 57/172 (33%), Positives = 101/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++++K LG G+F +V L +H +T A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>AKT3_RAT (Q63484) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) Length = 454 Score = 121 bits (304), Expect = 1e-27 Identities = 65/172 (37%), Positives = 97/172 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R + + A+K++ KE +I V E V++ RHP Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L K R+ VMEYV GG L+ H+ ED TR ++VSAL + H+ + Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K +NL++D+ G++K+ DFGL T A + T CGTP Y+ PEV Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGIT--DAATMKTFCGTPEYLAPEV 317
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 121 bits (304), Expect = 1e-27 Identities = 59/172 (34%), Positives = 106/172 (61%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +K++G+G F KVY R +T E A+KVM K+ +++ + +K E ++ ++ HP Sbjct: 134 FEVMKVVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDHPF 193 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IVQL K R+++V++++ GG L+ + G +ED R ++VSA++ H +G+ Sbjct: 194 IVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGI 253 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRD+KP+N+L+D G++ + DFGL+ + R +++CGT Y+ PE+ Sbjct: 254 MHRDLKPENILMDTDGHVMLTDFGLAKEFEENTRS---NSMCGTTEYMAPEI 302
>AKT3_MOUSE (Q9WUA6) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) Length = 479 Score = 121 bits (304), Expect = 1e-27 Identities = 65/172 (37%), Positives = 97/172 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R + + A+K++ KE +I V E V++ RHP Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L K R+ VMEYV GG L+ H+ ED TR ++VSAL + H+ + Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K +NL++D+ G++K+ DFGL T A + T CGTP Y+ PEV Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGIT--DAATMKTFCGTPEYLAPEV 317
>AKT3_HUMAN (Q9Y243) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2) Length = 479 Score = 121 bits (304), Expect = 1e-27 Identities = 65/172 (37%), Positives = 97/172 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R + + A+K++ KE +I V E V++ RHP Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L K R+ VMEYV GG L+ H+ ED TR ++VSAL + H+ + Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K +NL++D+ G++K+ DFGL T A + T CGTP Y+ PEV Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGIT--DAATMKTFCGTPEYLAPEV 317
>SAPK8_ORYSA (Q7Y0B9) Serine/threonine-protein kinase SAPK8 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 8) Length = 371 Score = 121 bits (303), Expect = 2e-27 Identities = 69/183 (37%), Positives = 103/183 (56%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE V+ +G GNF L R T E VA+K +++ + I ++REI R L+HP Sbjct: 32 RYELVRDIGSGNFGVARLMRDRRTMELVAVKYIERGEKID----DNVQREIINHRSLKHP 87 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I N EDE R FQQL+S +++CH+ Sbjct: 88 NIIRFKEVILTPTHLAIVMEYASGGELFERICKNVRFSEDEARYFFQQLISGVSYCHSMQ 147 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 V HRD+K +N L+D LK+ DFG S + ++LH + GTP Y+ PEV Sbjct: 148 VCHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVL 200 Query: 583 ARR 591 ++ Sbjct: 201 LKK 203
>MAST1_MOUSE (Q9R1L5) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1566 Score = 121 bits (303), Expect = 2e-27 Identities = 67/196 (34%), Positives = 102/196 (52%), Gaps = 13/196 (6%) Frame = +1 Query: 43 RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM 222 +P + ++ +KL+ G + VYL RH DT++ A+K ++K+ LI +QQ E ++ Sbjct: 368 KPPGESDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDIL 427 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 +P +V + + + +VMEYV GG + G L + R F + V AL Sbjct: 428 TFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALE 487 Query: 403 FCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLS-------------AHADTARREALLHT 543 + H G+ HRD+KPDNLL+ G++K+ DFGLS H + RE L Sbjct: 488 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQ 547 Query: 544 VCGTPLYVPPEVFARR 591 VCGTP Y+ PEV R+ Sbjct: 548 VCGTPEYIAPEVILRQ 563
>KAPB2_BOVIN (P24256) cAMP-dependent protein kinase, beta-2-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-2) Length = 397 Score = 121 bits (303), Expect = 2e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 90 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 149 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 150 LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 209 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 210 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 256
>MAST1_RAT (Q810W7) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 121 bits (303), Expect = 2e-27 Identities = 67/196 (34%), Positives = 102/196 (52%), Gaps = 13/196 (6%) Frame = +1 Query: 43 RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM 222 +P + ++ +KL+ G + VYL RH DT++ A+K ++K+ LI +QQ E ++ Sbjct: 369 KPPGESDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDIL 428 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 +P +V + + + +VMEYV GG + G L + R F + V AL Sbjct: 429 TFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALE 488 Query: 403 FCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLS-------------AHADTARREALLHT 543 + H G+ HRD+KPDNLL+ G++K+ DFGLS H + RE L Sbjct: 489 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQ 548 Query: 544 VCGTPLYVPPEVFARR 591 VCGTP Y+ PEV R+ Sbjct: 549 VCGTPEYIAPEVILRQ 564
>MAST1_HUMAN (Q9Y2H9) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 121 bits (303), Expect = 2e-27 Identities = 68/203 (33%), Positives = 103/203 (50%), Gaps = 13/203 (6%) Frame = +1 Query: 22 GDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQI 201 G + +P ++ +KL+ G + VYL RH DT++ A+K ++K+ LI +QQ Sbjct: 360 GRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQA 419 Query: 202 KREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQ 381 E ++ +P +V + + + +VMEYV GG + G L + R F Sbjct: 420 FVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFA 479 Query: 382 QLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLS-------------AHADTAR 522 + V AL + H G+ HRD+KPDNLL+ G++K+ DFGLS H + Sbjct: 480 ETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDA 539 Query: 523 REALLHTVCGTPLYVPPEVFARR 591 RE L VCGTP Y+ PEV R+ Sbjct: 540 REFLDKQVCGTPEYIAPEVILRQ 562
>KAPCB_HUMAN (P22694) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 121 bits (303), Expect = 2e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPCA_MOUSE (P05132) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 121 bits (303), Expect = 2e-27 Identities = 56/173 (32%), Positives = 102/173 (58%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 +++++K LG G+F +V L +H ++ A+K++DK+K++KL ++ E +++ + P Sbjct: 42 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 101 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ Sbjct: 102 FLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 161 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 162 LIYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPB1_BOVIN (P05131) cAMP-dependent protein kinase, beta-1-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-1) Length = 350 Score = 121 bits (303), Expect = 2e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 121 bits (303), Expect = 2e-27 Identities = 57/171 (33%), Positives = 104/171 (60%), Gaps = 1/171 (0%) Frame = +1 Query: 79 LLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLH 258 LLG+G+FA VY A + T EVAIK++DK+ + K G VQ+++ E+ + +L+HP++++L+ Sbjct: 17 LLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELY 76 Query: 259 KVMACKSRIFVVMEYVRGGPLYRHIPAN-GGLKEDETRRIFQQLVSALTFCHAQGVYHRD 435 + +++V+E G + R++ E E R Q+++ + + H+ G+ HRD Sbjct: 77 NYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRD 136 Query: 436 IKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 + N+L+ + N+K+ADFGL+ + + +T+CGTP Y+ PE+ R Sbjct: 137 LTLSNILLTRNMNIKIADFGLATQLNMPHEKH--YTLCGTPNYISPEIATR 185
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 120 bits (302), Expect = 2e-27 Identities = 68/179 (37%), Positives = 105/179 (58%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ +LG G F++V LA T++ VAIK + KE L G ++ EIAV+ +++HPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALE--GKEGSMENEIAVLHKIKHPN 77 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L + ++++M+ V GG L+ I G E + R+ Q++ A+ + H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 424 YHRDIKPDNLL---VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL +DE + ++DFGLS D ++L T CGTP YV PEV A++ Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPG---SVLSTACGTPGYVAPEVLAQK 193
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 120 bits (302), Expect = 2e-27 Identities = 64/175 (36%), Positives = 104/175 (59%), Gaps = 3/175 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 YE + LG G F+ VYL + TK+ AIKV++K +L K + +K E+ +++++ HPN Sbjct: 8 YEFKEELGRGAFSIVYLGENKQTKQRYAIKVINKSELGK-DYEKNLKMEVDILKKVNHPN 66 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I+ L ++ ++++VME V GG L+ I G E + + +++VSA+ + H + Sbjct: 67 IIALKELFDTPEKLYLVMELVTGGELFDKIVEKGSYSEADAANLVKKIVSAVGYLHGLNI 126 Query: 424 YHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRD+KP+NLL+ + H + +ADFGLS + ++ T CGTP YV PEV Sbjct: 127 VHRDLKPENLLLKSKENHLEVAIADFGLS---KIIGQTLVMQTACGTPSYVAPEV 178
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 120 bits (302), Expect = 2e-27 Identities = 63/182 (34%), Positives = 110/182 (60%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P ++E +K+LG+G+F KV+L R + D+ A+KV+ K L K+ Q+ K E ++ Sbjct: 101 PRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATL-KVRDRQRTKLERNILA 159 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP IV+LH + +++++++++RGG L+ + ED+ + +L AL Sbjct: 160 HISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEH 219 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+D G++KV DFGLS A + ++ ++ CGT Y+ PEV Sbjct: 220 LHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKT--YSFCGTVEYMAPEVIN 277 Query: 586 RR 591 RR Sbjct: 278 RR 279 Score = 65.9 bits (159), Expect = 9e-11 Identities = 48/182 (26%), Positives = 87/182 (47%), Gaps = 6/182 (3%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRLRHP 240 YE ++ +G G + V+ + T+ + A+K++ K AV E+ ++ R H Sbjct: 454 YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKK-------AVFDATEEVDILLRHSHHQ 506 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGL-KEDETRRIFQQLVSALTFCHAQ 417 +V+L V ++ I+++ E GG L + L E E I L++A+ + H+Q Sbjct: 507 FVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQ 566 Query: 418 GVYHRDIKPDNLLV----DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 V HRD+ N+L + +L++ DFG + + +L T C T +V PEV Sbjct: 567 QVAHRDLTAANILFALKDGDPSSLRIVDFGFA--KQSRAENGMLMTPCYTAQFVAPEVLR 624 Query: 586 RR 591 ++ Sbjct: 625 KQ 626
>KAPCB_RAT (P68182) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 120 bits (301), Expect = 3e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPCB_MOUSE (P68181) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 120 bits (301), Expect = 3e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPCB_CRIGR (P68180) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 120 bits (301), Expect = 3e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPCA_RAT (P27791) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 120 bits (301), Expect = 3e-27 Identities = 56/172 (32%), Positives = 101/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++++K LG G+F +V L +H ++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D+ G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDQQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KAPCB_PIG (P05383) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 120 bits (300), Expect = 4e-27 Identities = 58/172 (33%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E+ K LG G+F +V L +H T++ A+K++DK+K++KL ++ E +++ + P Sbjct: 43 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 102 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+L S +++VMEYV GG ++ H+ G E R Q+V + H+ + Sbjct: 103 LVRLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 162 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G ++V DFG + R + T+CGTP Y+ PE+ Sbjct: 163 IYRDLKPENLLIDHQGYIQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 119 bits (298), Expect = 7e-27 Identities = 67/179 (37%), Positives = 105/179 (58%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ +LG G F++V LA T++ VAIK + K+ L G ++ EIAV+ +++HPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALE--GKEGSMENEIAVLHKIKHPN 77 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L + ++++M+ V GG L+ I G E + R+ Q++ A+ + H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 424 YHRDIKPDNLL---VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL +DE + ++DFGLS D ++L T CGTP YV PEV A++ Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPG---SVLSTACGTPGYVAPEVLAQK 193
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 119 bits (298), Expect = 7e-27 Identities = 67/179 (37%), Positives = 105/179 (58%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ +LG G F++V LA T++ VAIK + K+ L G ++ EIAV+ +++HPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALE--GKEGSMENEIAVLHKIKHPN 77 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L + ++++M+ V GG L+ I G E + R+ Q++ A+ + H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 424 YHRDIKPDNLL---VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL +DE + ++DFGLS D ++L T CGTP YV PEV A++ Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPG---SVLSTACGTPGYVAPEVLAQK 193
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 119 bits (298), Expect = 7e-27 Identities = 59/173 (34%), Positives = 103/173 (59%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 ++E+++ LG G+F +V L RH +T A+K+++K+K++K+ V+ I E +++ + P Sbjct: 42 QFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFP 101 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V+L S +++VMEYV GG ++ + G E Q+V A+ + H+ Sbjct: 102 FLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLD 161 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + HRD+KP+NLL+D+ G L+V DFG + R + T+CGTP Y+ PE+ Sbjct: 162 LIHRDLKPENLLIDQQGYLQVTDFGFA-----KRVKGRTWTLCGTPEYLAPEI 209
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 119 bits (298), Expect = 7e-27 Identities = 61/169 (36%), Positives = 101/169 (59%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LGEG + +V L + T E VA+K++D +K A +++E+ + + L+ +I++ Sbjct: 28 LGEGAYGEVKLLINRQTGEAVAMKMVDLKK--HPDAANSVRKEVCIQKMLQDKHILRFFG 85 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 + S ++ +EY GG L+ I + G+ + E +R F QL+S L + H +G+ HRD+K Sbjct: 86 KRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLK 145 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 P+NLL+DEH N+K++DFG++ +E LL CGT YV PEV + Sbjct: 146 PENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQK 194
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 119 bits (297), Expect = 9e-27 Identities = 61/176 (34%), Positives = 98/176 (55%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E K LG+G F KVY RH T A+KVM+KE++IK +Q +RE+ + L HPN Sbjct: 104 FELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPN 163 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + + + + R++++MEY+ G +Y+ + +G + Q+ +AL + H + + Sbjct: 164 LTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKNI 223 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRDIKP+N+L+ + +K+ DFG S R TVCGT Y+ PE+ R Sbjct: 224 IHRDIKPENILIGFNNVIKLTDFGWSIINPPENRR---KTVCGTIDYLSPEMVESR 276
>SAPK1_ORYSA (Q75LR7) Serine/threonine-protein kinase SAPK1 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 1) Length = 342 Score = 119 bits (297), Expect = 9e-27 Identities = 67/183 (36%), Positives = 103/183 (56%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE ++ +G GNF L R + T A+K +++ I + ++REI R L+HP Sbjct: 3 RYEVMRDIGSGNFGVAKLVRDVATNHLFAVKFIERGLKID----EHVQREIMNHRSLKHP 58 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I G EDE R FQQL+S +++CH+ Sbjct: 59 NIIRFKEVVLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQ 118 Query: 421 VYHRDIKPDNLLVDEH--GNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 V HRD+K +N L+D LK+ DFG S + ++LH + GTP Y+ PEV Sbjct: 119 VCHRDLKLENTLLDGSVTPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVL 171 Query: 583 ARR 591 +R+ Sbjct: 172 SRK 174
>AAIP_WHEAT (Q02066) Abscisic acid-inducible protein kinase (EC 2.7.11.1)| (Fragment) Length = 332 Score = 119 bits (297), Expect = 9e-27 Identities = 67/175 (38%), Positives = 100/175 (57%), Gaps = 6/175 (3%) Frame = +1 Query: 85 GEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHKV 264 G GNF L R + TKE A+K +++ I + ++REI R L+HPNI++ +V Sbjct: 1 GSGNFGVAKLVRDVRTKEHFAVKFIERGHKID----EHVQREIMNHRSLKHPNIIRFKEV 56 Query: 265 MACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIKP 444 + + + +VMEY GG L++ I G EDE R FQQL+S +++CH+ V HRD+K Sbjct: 57 VLTPTHLAIVMEYASGGELFQRICNAGRFSEDEGRFFFQQLISGVSYCHSMQVCHRDLKL 116 Query: 445 DNLLVDEH--GNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVFARR 591 +N L+D LK+ DFG S + ++LH + GTP Y+ PEV +RR Sbjct: 117 ENTLLDGSVAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVLSRR 164
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 118 bits (295), Expect = 1e-26 Identities = 55/172 (31%), Positives = 101/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++Q+++LG G F KVYL ++ A+K ++K +++L V+ + E +++ + HP Sbjct: 336 FKQIRVLGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPF 395 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L++ + +++++ EYV GG ++ H+ + + ++V AL F H Q + Sbjct: 396 IVNLYQAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAAEIVLALEFLHKQNI 455 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G++K+ DFG + R E T+CGTP Y+ PE+ Sbjct: 456 VYRDLKPENLLIDNQGHIKITDFGFA-----KRVEDRTFTLCGTPEYLAPEI 502
>SAPKA_ORYSA (Q75H77) Serine/threonine-protein kinase SAPK10 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 10) Length = 362 Score = 118 bits (295), Expect = 1e-26 Identities = 68/183 (37%), Positives = 102/183 (55%), Gaps = 6/183 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RYE V+ +G GNF L R + VA+K +++ I + ++REI R LRHP Sbjct: 22 RYELVRDIGSGNFGVARLMRSRADGQLVAVKYIERGDKID----ENVQREIINHRSLRHP 77 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI++ +V+ + + +VMEY GG L+ I G EDE R FQQL+S +++CH+ Sbjct: 78 NIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQ 137 Query: 421 VYHRDIKPDNLLVD--EHGNLKVADFGLSAHADTARREALLH----TVCGTPLYVPPEVF 582 V HRD+K +N L+D LK+ DFG S + ++LH + GTP Y+ PEV Sbjct: 138 VCHRDLKLENTLLDGSTAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVL 190 Query: 583 ARR 591 ++ Sbjct: 191 LKK 193
>AKT2A_XENLA (Q7ZX15) RAC-beta serine/threonine-protein kinase-A (EC 2.7.11.1)| (RAC-PK-beta-A) (Protein kinase Akt-2-A) (Protein kinase B, beta-A) (PKB beta-A) Length = 486 Score = 118 bits (295), Expect = 1e-26 Identities = 64/172 (37%), Positives = 94/172 (54%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R T A+K++ KE +I V E V++ +HP Sbjct: 157 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTLTESRVLQNTKHPF 216 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ V Sbjct: 217 LTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRNV 276 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RDIK +NL++D+ G++K+ DFGL T A + T CGTP Y+ PEV Sbjct: 277 VYRDIKLENLMLDKDGHVKITDFGLCKEGIT--DGATMRTFCGTPEYLAPEV 326
>AKT2_RAT (P47197) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 118 bits (295), Expect = 1e-26 Identities = 65/172 (37%), Positives = 94/172 (54%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R T A+K++ KE +I V E V++ RHP Sbjct: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L R+ VMEY GG L+ H+ ED R ++VSAL + H+ V Sbjct: 212 LTALKYAFQTHDRLCFVMEYANGGDLFFHLSRERVFTEDRARFYGAEIVSALEYLHSTDV 271 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RDIK +NL++D+ G++K+ DFGLS + A + T CGTP Y+ PEV Sbjct: 272 VYRDIKLENLMLDKDGHIKITDFGLS--KEGISDGATMKTFCGTPEYLAPEV 321
>AKT2B_XENLA (Q6IP76) RAC-beta serine/threonine-protein kinase-B (EC 2.7.11.1)| (RAC-PK-beta-B) (Protein kinase Akt-2-B) (Protein kinase B, beta-B) (PKB beta-B) Length = 485 Score = 118 bits (295), Expect = 1e-26 Identities = 67/180 (37%), Positives = 98/180 (54%), Gaps = 1/180 (0%) Frame = +1 Query: 43 RPKLPAR-YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAV 219 RPK+ ++ +KLLG+G F KV L R T A+K++ KE +I V E V Sbjct: 148 RPKVTMNDFDYLKLLGKGTFGKVILVREKATGLYYAMKILRKEVIIAKDEVAHTLTESRV 207 Query: 220 MRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSAL 399 ++ +HP + L R+ VMEY GG L+ H+ ED R ++VSAL Sbjct: 208 LQNTKHPFLTGLKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSAL 267 Query: 400 TFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + H++ V +RDIK +NL++D+ G++K+ DFGL T A + T CGTP Y+ PEV Sbjct: 268 EYLHSRNVVYRDIKLENLMLDKDGHVKITDFGLCKEGIT--DGATMRTFCGTPEYLAPEV 325
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 117 bits (294), Expect = 2e-26 Identities = 60/182 (32%), Positives = 112/182 (61%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+++E +K+LG+G+F KV+L + + D ++ A+KV+ K L K+ + K E ++ Sbjct: 65 PSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL-KVRDRVRTKMERDILV 123 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP IV+LH + +++++++++RGG L+ + E++ + +L AL Sbjct: 124 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS + ++A ++ CGT Y+ PEV Sbjct: 184 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKA--YSFCGTVEYMAPEVVN 241 Query: 586 RR 591 RR Sbjct: 242 RR 243 Score = 89.4 bits (220), Expect = 7e-18 Identities = 60/181 (33%), Positives = 89/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 YE + +G G+++ H T E A+K++DK K + EI ++ R +HP Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK-------RDPTEEIEILLRYGQHP 474 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V ++VV E ++GG L I E E + + + + HAQG Sbjct: 475 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 534 Query: 421 VYHRDIKPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE GN +++ DFG + LL T C T +V PEV R Sbjct: 535 VVHRDLKPSNILYVDESGNPESIRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKR 592 Query: 589 R 591 + Sbjct: 593 Q 593
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 117 bits (294), Expect = 2e-26 Identities = 60/182 (32%), Positives = 112/182 (61%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+++E +K+LG+G+F KV+L + + D ++ A+KV+ K L K+ + K E ++ Sbjct: 65 PSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL-KVRDRVRTKMERDILV 123 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP IV+LH + +++++++++RGG L+ + E++ + +L AL Sbjct: 124 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS + ++A ++ CGT Y+ PEV Sbjct: 184 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKA--YSFCGTVEYMAPEVVN 241 Query: 586 RR 591 RR Sbjct: 242 RR 243 Score = 89.4 bits (220), Expect = 7e-18 Identities = 60/181 (33%), Positives = 89/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 YE + +G G+++ H T E A+K++DK K + EI ++ R +HP Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK-------RDPTEEIEILLRYGQHP 474 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V ++VV E ++GG L I E E + + + + HAQG Sbjct: 475 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 534 Query: 421 VYHRDIKPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE GN +++ DFG + LL T C T +V PEV R Sbjct: 535 VVHRDLKPSNILYVDESGNPESIRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKR 592 Query: 589 R 591 + Sbjct: 593 Q 593
>KIN4_YEAST (Q01919) Serine/threonine-protein kinase KIN4 (EC 2.7.11.1)| Length = 800 Score = 117 bits (293), Expect = 2e-26 Identities = 67/173 (38%), Positives = 102/173 (58%), Gaps = 7/173 (4%) Frame = +1 Query: 82 LGEGNFAKVYL-----ARHMDTKEEVAIKVMDKEKLIKLGAVQQIK--REIAVMRRLRHP 240 LGEG F KV L + + ++VAIK++ ++ IK A ++IK REI ++ L HP Sbjct: 52 LGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDT-IKKDADKEIKIYREINALKHLTHP 110 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L +V+ I +V+E+V GG Y++I LKE R+F QL+S + + H +G Sbjct: 111 NIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKG 170 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + HRD+K +NLL+D+H NL + DFG + L+ T CG+P Y PE+ Sbjct: 171 LVHRDLKLENLLLDKHENLVITDFGFV--NEFFEDNELMKTSCGSPCYAAPEL 221
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 117 bits (293), Expect = 2e-26 Identities = 61/182 (33%), Positives = 108/182 (59%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+++E +K+LG+G++ KV+L R + D + A+KV+ K L V+ K E ++ Sbjct: 56 PSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILA 114 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP IV+LH + +++++++++RGG L+ + E++ + +L AL Sbjct: 115 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 174 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H G+ +RD+KP+N+L+DE G++K+ DFGLS A + A ++ CGT Y+ PEV Sbjct: 175 LHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRA--YSFCGTIEYMAPEVVN 232 Query: 586 RR 591 RR Sbjct: 233 RR 234 Score = 90.1 bits (222), Expect = 4e-18 Identities = 59/181 (32%), Positives = 90/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 YE + +G G+++ H T E A+K++DK K + EI ++ R +HP Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSK-------RDPSEEIEILLRYGQHP 467 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V +++VME +RGG L I E E + + + + H+QG Sbjct: 468 NIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQG 527 Query: 421 VYHRDIKPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L +DE GN +++ DFG + LL T C T +V PEV R Sbjct: 528 VVHRDLKPSNILYMDESGNPESIRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKR 585 Query: 589 R 591 + Sbjct: 586 Q 586
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 117 bits (293), Expect = 2e-26 Identities = 58/172 (33%), Positives = 97/172 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + ++G+G+F KV + + A+KV+ K+ +I V K E +++ + HP Sbjct: 153 FELLNVIGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSEKTILQCISHPF 212 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV LH K ++++V+++V GG L+ H+ G E + ++VSAL H Q + Sbjct: 213 IVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIVSALDHLHKQDI 272 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+N+L+D G++ + DFGLS +T T CGTP Y+ PEV Sbjct: 273 VYRDLKPENILLDSEGHICITDFGLSKKIETTDG---TFTFCGTPEYLAPEV 321
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 117 bits (292), Expect = 3e-26 Identities = 67/184 (36%), Positives = 104/184 (56%), Gaps = 5/184 (2%) Frame = +1 Query: 52 LPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL 231 LP +Y ++LG G +A V A H++T + A K+M+K+ + K +K EIA+++R+ Sbjct: 27 LPCKYRVGRVLGGGTYATVREAVHIETNKMYAAKIMNKKMMEK--KQDFVKNEIAILKRV 84 Query: 232 --RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 HPNI+ L + ++++ E GG L+ I A G E + + + SA+ + Sbjct: 85 SYEHPNILHLVDFFETVNNLYLITELATGGELFDRICAKGSFYEADAAALMRTTTSAVKY 144 Query: 406 CHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 H G+ HRD+KP+NLL D + +L +ADFGLS H + +L T CGTP Y+ PE Sbjct: 145 LHDNGIVHRDLKPENLLYRSKDPNSDLLIADFGLS-HFYEDSQYYMLMTACGTPEYMAPE 203 Query: 577 VFAR 588 VF R Sbjct: 204 VFRR 207
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 117 bits (292), Expect = 3e-26 Identities = 61/182 (33%), Positives = 109/182 (59%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+++E +K+LG+G++ KV+L R + D + A+KV+ K L V+ K E ++ Sbjct: 56 PSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILA 114 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP IV+LH + +++++++++RGG L+ + E++ + +L AL Sbjct: 115 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 174 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS A + A ++ CGT Y+ PEV Sbjct: 175 LHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRA--YSFCGTIEYMAPEVVN 232 Query: 586 RR 591 RR Sbjct: 233 RR 234 Score = 87.0 bits (214), Expect = 4e-17 Identities = 59/181 (32%), Positives = 89/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 YE + +G G+++ H T E A+K++DK K + EI ++ R +HP Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSK-------RDPSEEIEILLRYGQHP 467 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V +++VME +RGG L I E E + + + + H+QG Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 527 Query: 421 VYHRDIKPDNLLV-DEHG---NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L DE G +++V DFG + LL T C T +V PEV R Sbjct: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG--NGLLMTPCYTANFVAPEVLKR 585 Query: 589 R 591 + Sbjct: 586 Q 586
>AKT2_MOUSE (Q60823) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 117 bits (292), Expect = 3e-26 Identities = 64/172 (37%), Positives = 94/172 (54%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R T A+K++ KE +I V E V++ RHP Sbjct: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ V Sbjct: 212 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDV 271 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RDIK +NL++D+ G++K+ DFGL + A + T CGTP Y+ PEV Sbjct: 272 VYRDIKLENLMLDKDGHIKITDFGLC--KEGISDGATMKTFCGTPEYLAPEV 321
>KAPC_CAEEL (P21137) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 404 Score = 116 bits (291), Expect = 4e-26 Identities = 55/172 (31%), Positives = 100/172 (58%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++++K LG G+F +V L +H + A+K++DK+K++KL V+ E +++ + P Sbjct: 81 FDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPF 140 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V + S +++V+E++ GG ++ H+ G E +R Q+V A + H+ + Sbjct: 141 LVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDL 200 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL+D G LK+ DFG + R + T+CGTP Y+ PE+ Sbjct: 201 IYRDLKPENLLIDSTGYLKITDFGFA-----KRVKGRTWTLCGTPEYLAPEI 247
>TSSK1_MOUSE (Q61241) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 364 Score = 116 bits (291), Expect = 4e-26 Identities = 65/169 (38%), Positives = 99/169 (58%), Gaps = 3/169 (1%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LGEG++AKV A K VA+K++D++K + + REI ++ L H +IV+ ++ Sbjct: 18 LGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLNHRSIVKTYE 77 Query: 262 VMACKS-RIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 + A ++++VME G L I G L+ED+ R+ F QL SA+ +CH V HRD+ Sbjct: 78 IFATSDGKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQLSSAIKYCHDLDVVHRDL 137 Query: 439 KPDNLLVDEHGNLKVADFGLSAHA--DTARREALLHTVCGTPLYVPPEV 579 K +NLL+D+ N+K++DFG S D + R L T CG+ Y PEV Sbjct: 138 KSENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFCGSAAYAAPEV 186
>TSSK1_HUMAN (Q9BXA7) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 367 Score = 116 bits (290), Expect = 6e-26 Identities = 66/169 (39%), Positives = 97/169 (57%), Gaps = 3/169 (1%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LGEG++AKV A K VAIK++D++K + + REI ++ L H +I++ ++ Sbjct: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77 Query: 262 VMACK-SRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 + ++++VME G L I G L EDE R+ F QL A+ +CH V HRD+ Sbjct: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137 Query: 439 KPDNLLVDEHGNLKVADFGLSAHA--DTARREALLHTVCGTPLYVPPEV 579 K DNLL+D+ N+K++DF S D + R AL T CG+P Y PEV Sbjct: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEV 186
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 116 bits (290), Expect = 6e-26 Identities = 66/182 (36%), Positives = 103/182 (56%), Gaps = 10/182 (5%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMD-TKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 Y + L+G G FA V+ RH T EVAIK ++K+ L K + + +EI +++ L+H Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQHE 66 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV L+ V + +F+VMEY GG L ++ A G L ED R Q+ +A+ H++G Sbjct: 67 NIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKG 126 Query: 421 VYHRDIKPDNLLVDEHG---------NLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 + HRD+KP N+L+ +K+ADFG + + + A T+CG+P+Y+ P Sbjct: 127 IIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAA---TLCGSPMYMAP 183 Query: 574 EV 579 EV Sbjct: 184 EV 185
>YP150_YEAST (Q12152) Putative serine/threonine-protein kinase YPL150W (EC| 2.7.11.1) Length = 901 Score = 116 bits (290), Expect = 6e-26 Identities = 62/176 (35%), Positives = 100/176 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ +K +GEG+F KVYLA H T +V +K DK I RE+ R+ P Sbjct: 41 YKILKQIGEGSFGKVYLALHRPTHRKVCLKTSDKND-------PNIVREVFYHRQFDFPY 93 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I +L++V+ +S++++ +EY G LY H+ + + E +F Q+ A+ + H+ Sbjct: 94 ITKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHC 153 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+K +N+L+D++GN K+ DFG + T + L TVCGT +Y+ PE+ RR Sbjct: 154 VHRDLKLENILLDKNGNAKLTDFGFTRECMT---KTTLETVCGTTVYMAPELIERR 206
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 115 bits (288), Expect = 9e-26 Identities = 65/196 (33%), Positives = 111/196 (56%), Gaps = 9/196 (4%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKL------IK 180 S + ++G ++ Y + LG G + V L T ++ A+K++ K L Sbjct: 159 SPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTN 218 Query: 181 LGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKED 360 ++ E +M+ L HP +V++H ++ +++V+E++RGG L I +N L ED Sbjct: 219 FSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSED 278 Query: 361 ETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREA 531 ++ F Q+ A+ + H +G+ HRD+KPDN+L+ DE LKV+DFGLS ++++ Sbjct: 279 ISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKF---VQKDS 335 Query: 532 LLHTVCGTPLYVPPEV 579 ++ T+CGTPLYV PEV Sbjct: 336 VMRTLCGTPLYVAPEV 351
>AKT2_HUMAN (P31751) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 115 bits (288), Expect = 9e-26 Identities = 63/172 (36%), Positives = 94/172 (54%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ +KLLG+G F KV L R T A+K++ KE +I V E V++ RHP Sbjct: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + L R+ VMEY GG L+ H+ E+ R ++VSAL + H++ V Sbjct: 212 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV 271 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RDIK +NL++D+ G++K+ DFGL + A + T CGTP Y+ PEV Sbjct: 272 VYRDIKLENLMLDKDGHIKITDFGLC--KEGISDGATMKTFCGTPEYLAPEV 321
>KPC2_APLCA (Q16975) Calcium-independent protein kinase C (EC 2.7.11.13) (APL| II) Length = 743 Score = 115 bits (288), Expect = 9e-26 Identities = 65/170 (38%), Positives = 92/170 (54%), Gaps = 1/170 (0%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR-RLRHPNIV 249 +K+LG+G+F KV LA T E AIKV+ K+ +I+ V+ E ++ +HP + Sbjct: 406 IKVLGKGSFGKVMLAEKKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILALSAKHPFLT 465 Query: 250 QLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYH 429 LH K R+F VMEYV GG L I E R ++ AL F H G+ + Sbjct: 466 ALHSSFQTKERLFFVMEYVNGGDLMFQIQRARKFDEPRARFYAAEVTLALMFLHRHGIIY 525 Query: 430 RDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 RD+K DN+L+D G+ K+ADFG+ T + L T CGTP Y+ PE+ Sbjct: 526 RDLKLDNILLDAEGHCKIADFGMCKEGMTENK--LTQTFCGTPDYIAPEI 573
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 115 bits (287), Expect = 1e-25 Identities = 65/178 (36%), Positives = 97/178 (54%), Gaps = 2/178 (1%) Frame = +1 Query: 49 KLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRR 228 ++ RY+ ++++G G A VYLA + EVAIK++ + +++ +RE Sbjct: 6 RISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRFDYANDNEFIRRFRREAQSASS 65 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFC 408 L HPNIV ++ + ++VMEYV G L +I ANG L E I +Q+VSA+ Sbjct: 66 LDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALNIMEQIVSAIAHA 125 Query: 409 HAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHT--VCGTPLYVPPE 576 H + HRDIKP N+L+D GN+KV DFG+ A + HT V G+ Y+ PE Sbjct: 126 HQNQIVHRDIKPHNILIDHMGNIKVTDFGI---ATALSSTTITHTNSVLGSVHYLSPE 180
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 115 bits (287), Expect = 1e-25 Identities = 64/179 (35%), Positives = 102/179 (56%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG G F++V LA T + A+K + K+ L G I+ EIAV+R+++H N Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL--KGKESSIENEIAVLRKIKHEN 80 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L + + +++VM+ V GG L+ I G E + + +Q++ A+ + H G+ Sbjct: 81 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 140 Query: 424 YHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL DE + ++DFGLS + ++ T CGTP YV PEV A++ Sbjct: 141 VHRDLKPENLLYYSQDEESKIMISDFGLS---KMEGKGDVMSTACGTPGYVAPEVLAQK 196
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 115 bits (287), Expect = 1e-25 Identities = 64/179 (35%), Positives = 102/179 (56%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG G F++V LA T + A+K + K+ L G I+ EIAV+R+++H N Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL--KGKESSIENEIAVLRKIKHEN 80 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L + + +++VM+ V GG L+ I G E + + +Q++ A+ + H G+ Sbjct: 81 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 140 Query: 424 YHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL DE + ++DFGLS + ++ T CGTP YV PEV A++ Sbjct: 141 VHRDLKPENLLYYSQDEESKIMISDFGLS---KMEGKGDVMSTACGTPGYVAPEVLAQK 196
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 115 bits (287), Expect = 1e-25 Identities = 62/177 (35%), Positives = 106/177 (59%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 RY L+G+G+F VY A D + VAIKV+ K ++ ++RE + RL+HP Sbjct: 3 RYAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATK-ELKNLRRECDIQARLKHP 61 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +++++ + K+ +FVV E+ L+R++ NG + E+ RR+ LVSAL + H+ Sbjct: 62 HVIEMIESFESKTDLFVVTEFALMD-LHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNR 120 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 + HRD+KP N+L+D++ + K+ DFGL+ + +L ++ GTPLY+ PE+ A + Sbjct: 121 ILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTH--VLTSIKGTPLYMAPELLAEQ 175
>KRAC_DICDI (P54644) RAC-family serine/threonine-protein kinase homolog (EC| 2.7.11.1) Length = 444 Score = 115 bits (287), Expect = 1e-25 Identities = 61/180 (33%), Positives = 101/180 (56%), Gaps = 6/180 (3%) Frame = +1 Query: 58 ARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRH 237 A +E + L+G+G+F KV R DT E A+KV+ K+ +++ V+ E +++++ H Sbjct: 118 ADFELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINH 177 Query: 238 PNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ 417 P +V L+ + +++ +++YV GG L+ H+ + ED R ++V AL H Sbjct: 178 PFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLHLS 237 Query: 418 GVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALL------HTVCGTPLYVPPEV 579 GV +RD+KP+NLL+ G++ + DFGL +E LL T CGTP Y+ PEV Sbjct: 238 GVIYRDLKPENLLLTNEGHICMTDFGLC-------KEGLLTPTDKTGTFCGTPEYLAPEV 290
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 115 bits (287), Expect = 1e-25 Identities = 61/182 (33%), Positives = 109/182 (59%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 PA++E +K+LG+G+F KV+L R D + A+KV+ K L K+ + K E ++ Sbjct: 70 PAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL-KVRDRVRTKMERDILV 128 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP IV+LH + +++++++++RGG ++ + E++ + +L AL Sbjct: 129 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDH 188 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H G+ +RD+KP+N+L+DE G++K+ DFGLS ++ +E ++ CGT Y+ PEV Sbjct: 189 LHQLGIVYRDLKPENILLDEIGHIKLTDFGLS--KESVDQEKKAYSFCGTVEYMAPEVVN 246 Query: 586 RR 591 RR Sbjct: 247 RR 248 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/181 (29%), Positives = 87/181 (48%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 YE + +G G+++ H T E A+K++DK K + EI ++ R +HP Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSK-------RDPSEEIEILMRYGQHP 478 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V +++V + ++GG L I E E I + + + H QG Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538 Query: 421 VYHRDIKPDNLL-VDEHG---NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L +DE ++++ DFG + LL T C T +V PEV + Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFA--KQLRGENGLLLTPCYTANFVAPEVLMQ 596 Query: 589 R 591 + Sbjct: 597 Q 597
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 115 bits (287), Expect = 1e-25 Identities = 63/170 (37%), Positives = 101/170 (59%), Gaps = 2/170 (1%) Frame = +1 Query: 76 KLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQL 255 +++G+G FA V A T + A+K++ K K+I G + + RE+ V+++L HP IV+L Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVI--GNMDGVTRELEVLQKLNHPRIVRL 259 Query: 256 HKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRD 435 ++VME+V GG L + A+G + ED R I +Q+++A+ + H+ G+ HRD Sbjct: 260 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRD 319 Query: 436 IKPDNLLV--DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +KPDN+L+ D+ +K+ DFGL A + + T CGT YV PEV Sbjct: 320 LKPDNILIEQDDPVLVKITDFGL---AKVQGNGSFMKTFCGTLAYVAPEV 366
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 115 bits (287), Expect = 1e-25 Identities = 65/181 (35%), Positives = 105/181 (58%), Gaps = 4/181 (2%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGA----VQQIKREIAVMRR 228 +Y ++++GEG+F +VY R + + VA+K + K LG ++ ++REI +MR Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPK-----LGRSEKELRNLQREIEIMRG 57 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFC 408 LRHPNIV + + VV +Y G L++ + +G L ED+ + I QLVSAL + Sbjct: 58 LRHPNIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYL 116 Query: 409 HAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 H+ + HRD+KP N+L+ + G +K+ DFG + T +L ++ GTPLY+ PE+ Sbjct: 117 HSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMST--NTMVLTSIKGTPLYMSPELVEE 174 Query: 589 R 591 R Sbjct: 175 R 175
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 115 bits (287), Expect = 1e-25 Identities = 67/179 (37%), Positives = 101/179 (56%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 YE + LG G F++V LA+ + VA+K + K+ L G ++ EIAV+RR+ HPN Sbjct: 15 YEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKAL--RGKEALVENEIAVLRRISHPN 72 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L V S +++ ME V GG L+ I G E + + Q++ A+++ H+ G+ Sbjct: 73 IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 132 Query: 424 YHRDIKPDNLLVD---EHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL E + V+DFGLS + +L T CGTP YV PE+ ++ Sbjct: 133 VHRDLKPENLLYATPFEDSKIMVSDFGLS----KIQAGNMLGTACGTPGYVAPELLEQK 187
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 115 bits (287), Expect = 1e-25 Identities = 67/179 (37%), Positives = 101/179 (56%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 YE + LG G F++V LA+ + VA+K + K+ L G ++ EIAV+RR+ HPN Sbjct: 15 YEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKAL--RGKEALVENEIAVLRRISHPN 72 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L V S +++ ME V GG L+ I G E + + Q++ A+++ H+ G+ Sbjct: 73 IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 132 Query: 424 YHRDIKPDNLLVD---EHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL E + V+DFGLS + +L T CGTP YV PE+ ++ Sbjct: 133 VHRDLKPENLLYATPFEDSKIMVSDFGLS----KIQAGNMLGTACGTPGYVAPELLEQK 187
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 115 bits (287), Expect = 1e-25 Identities = 67/179 (37%), Positives = 101/179 (56%), Gaps = 3/179 (1%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 YE + LG G F++V LA+ + VA+K + K+ L G ++ EIAV+RR+ HPN Sbjct: 15 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL--RGKEALVENEIAVLRRISHPN 72 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV L V S +++ ME V GG L+ I G E + + Q++ A+++ H+ G+ Sbjct: 73 IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 132 Query: 424 YHRDIKPDNLLVD---EHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+NLL E + V+DFGLS + +L T CGTP YV PE+ ++ Sbjct: 133 VHRDLKPENLLYATPFEDSKIMVSDFGLS----KIQAGNMLGTACGTPGYVAPELLEQK 187
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 114 bits (286), Expect = 2e-25 Identities = 67/196 (34%), Positives = 108/196 (55%), Gaps = 8/196 (4%) Frame = +1 Query: 25 DGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTK---EEVAIKVMDKEKLIKLGAVQ 195 D + G K +++E + +G G+F A+ + ++VA+KV+ K K+ A++ Sbjct: 135 DKSFGFSKKFGSKFEVGEEVGRGHFGYTCRAKFKKGEFKGQDVAVKVIPKAKMTTAIAIE 194 Query: 196 QIKREIAVMRRLR-HPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGG-LKEDETR 369 ++RE+ ++R L H N+VQ + + ++VVME GG L I + GG ED+ + Sbjct: 195 DVRREVKILRALTGHNNLVQFYDAFEDHTNVYVVMELCEGGELLDRILSRGGKYTEDDAK 254 Query: 370 RIFQQLVSALTFCHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLH 540 + Q+++ + FCH QGV HRD+KP+N L DE LK DFGLS D + + L+ Sbjct: 255 AVMIQILNVVAFCHLQGVVHRDLKPENFLFKSKDEDSQLKAIDFGLS---DYVKPDERLN 311 Query: 541 TVCGTPLYVPPEVFAR 588 + G+ YV PEV R Sbjct: 312 DIVGSAYYVAPEVLHR 327
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 114 bits (286), Expect = 2e-25 Identities = 64/177 (36%), Positives = 101/177 (57%), Gaps = 10/177 (5%) Frame = +1 Query: 79 LLGEGNFAKVYLARHMD-TKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQL 255 L+G G FA V+ RH T EVAIK ++K+ L K + + +EI +++ L+H NIV L Sbjct: 14 LVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQHENIVAL 71 Query: 256 HKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRD 435 + V + +F+VMEY GG L ++ A G L ED R Q+ +A+ H++G+ HRD Sbjct: 72 YDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRD 131 Query: 436 IKPDNLLVDEHG---------NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +KP N+L+ +K+ADFG + + + + T+CG+P+Y+ PEV Sbjct: 132 LKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHS---NTMAATLCGSPMYMAPEV 185
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 114 bits (286), Expect = 2e-25 Identities = 59/182 (32%), Positives = 110/182 (60%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+++E +K+LG+G+F KV+L R + D+ A+KV+ K L K+ + K E ++ Sbjct: 77 PSQFELLKVLGQGSFGKVFLVRKITPPDSNHLYAMKVLKKATL-KVRDRVRTKIERDILA 135 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP +V+LH + +++++++++RGG L+ + E++ + +L L Sbjct: 136 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 195 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS A ++A ++ CGT Y+ PEV Sbjct: 196 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA--YSFCGTVEYMAPEVVN 253 Query: 586 RR 591 R+ Sbjct: 254 RQ 255 Score = 88.6 bits (218), Expect = 1e-17 Identities = 59/181 (32%), Positives = 88/181 (48%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 Y + +G G+++ H T E A+KV+DK K + EI ++ R +HP Sbjct: 435 YVVKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSK-------RDPSEEIEILLRYGQHP 487 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V +++V E +RGG L I E E + + + + H+QG Sbjct: 488 NIITLKDVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQG 547 Query: 421 VYHRDIKPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE GN +++ DFG + LL T C T +V PEV R Sbjct: 548 VVHRDLKPSNILYVDESGNPESIRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKR 605 Query: 589 R 591 + Sbjct: 606 Q 606
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 114 bits (286), Expect = 2e-25 Identities = 59/182 (32%), Positives = 110/182 (60%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+++E +K+LG+G+F KV+L R + D+ A+KV+ K L K+ + K E ++ Sbjct: 59 PSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILA 117 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP +V+LH + +++++++++RGG L+ + E++ + +L L Sbjct: 118 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS A ++A ++ CGT Y+ PEV Sbjct: 178 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA--YSFCGTVEYMAPEVVN 235 Query: 586 RR 591 R+ Sbjct: 236 RQ 237 Score = 88.6 bits (218), Expect = 1e-17 Identities = 60/181 (33%), Positives = 88/181 (48%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 Y + +G G+++ H T E A+KV+DK K + EI ++ R +HP Sbjct: 407 YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQHP 459 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V +++V E +RGG L I E E + + + + H+QG Sbjct: 460 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQG 519 Query: 421 VYHRDIKPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE GN L++ DFG + LL T C T +V PEV R Sbjct: 520 VVHRDLKPSNILYVDESGNPECLRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKR 577 Query: 589 R 591 + Sbjct: 578 Q 578
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 114 bits (286), Expect = 2e-25 Identities = 63/179 (35%), Positives = 106/179 (59%), Gaps = 9/179 (5%) Frame = +1 Query: 76 KLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQL 255 ++LG+G+F V A +T+ + AIK ++KEK AV+ ++RE+ +++ ++H +I+ L Sbjct: 120 RILGKGSFGIVIEATDKETETKWAIKKVNKEKAGS-SAVKLLEREVNILKSVKHEHIIHL 178 Query: 256 HKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRD 435 +V ++++VME G L + G E+ETR I Q L SA+ + H + HRD Sbjct: 179 EQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRD 238 Query: 436 IKPDNL-----LVDEHG----NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 +K +N+ L+D++ N+KV DFGL+ +R EA+L CGTP+Y+ PEV + Sbjct: 239 LKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQ-SRSEAMLQATCGTPIYMAPEVIS 296
>AKT1_BOVIN (Q01314) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) Length = 480 Score = 114 bits (285), Expect = 2e-25 Identities = 63/173 (36%), Positives = 96/173 (55%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E VKLLG+G F KV L + T A+K++ KE ++ V E V++ RHP+ Sbjct: 150 FEYVKLLGKGTFGKVILVKEKATAAYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPS 209 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ-G 420 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKE 269 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V +RD+K +NL++D+ G++K+ DFGL + + A + T CGTP Y+ PEV Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEV 320
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 114 bits (285), Expect = 2e-25 Identities = 59/182 (32%), Positives = 109/182 (59%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+ +E +K+LG+G+F KV+L R + D+ A+KV+ K L K+ + K E ++ Sbjct: 59 PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILA 117 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP +V+LH + +++++++++RGG L+ + E++ + +L L Sbjct: 118 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS A ++A ++ CGT Y+ PEV Sbjct: 178 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA--YSFCGTVEYMAPEVVN 235 Query: 586 RR 591 R+ Sbjct: 236 RQ 237 Score = 89.4 bits (220), Expect = 7e-18 Identities = 60/181 (33%), Positives = 89/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 Y + +G G++++ H T E A+KV+DK K + EI ++ R +HP Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQHP 470 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V +++V E +RGG L I E E + + + + H+QG Sbjct: 471 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 530 Query: 421 VYHRDIKPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE GN L++ DFG + LL T C T +V PEV R Sbjct: 531 VVHRDLKPSNILYVDESGNPECLRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKR 588 Query: 589 R 591 + Sbjct: 589 Q 589
>CDR2_SCHPO (P87050) Mitosis inducer protein kinase cdr2 (EC 2.7.11.1)| Length = 775 Score = 114 bits (285), Expect = 2e-25 Identities = 55/170 (32%), Positives = 97/170 (57%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG G LA+H +T + +K + + +I+ E+ ++R + HPN++QL Sbjct: 16 LGSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLID 75 Query: 262 VMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIK 441 V++ + ++FVV+EY+ GG L+ + G E +T + Q++ L +CH + HRD+K Sbjct: 76 VISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLK 135 Query: 442 PDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 P+NL +D HG++K+ +FG+++ + LL T CG+P Y PE+ R Sbjct: 136 PENLYLDAHGSIKIGEFGMASIQQPGK---LLQTSCGSPHYASPEIIMGR 182
>SGK1_RABIT (Q9XT18) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 114 bits (284), Expect = 3e-25 Identities = 57/180 (31%), Positives = 101/180 (56%), Gaps = 1/180 (0%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRL 231 P+ + +K++G+G+F KV LARH + A+KV+ K+ ++K + I E V+ + + Sbjct: 95 PSDFHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 154 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 +HP +V LH +++ V++Y+ GG L+ H+ E R ++ SAL + H Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 + + +RD+KP+N+L+D G++ + DFGL + T CGTP Y+ PEV ++ Sbjct: 215 SLNIVYRDLKPENILLDSQGHIVLTDFGLC--KENIEHNGTTSTFCGTPEYLAPEVLHKQ 272
>SGK1_HUMAN (O00141) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 114 bits (284), Expect = 3e-25 Identities = 57/180 (31%), Positives = 102/180 (56%), Gaps = 1/180 (0%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRL 231 P+ + +K++G+G+F KV LARH + A+KV+ K+ ++K + I E V+ + + Sbjct: 95 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 154 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 +HP +V LH +++ V++Y+ GG L+ H+ E R ++ SAL + H Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 + + +RD+KP+N+L+D G++ + DFGL + + T CGTP Y+ PEV ++ Sbjct: 215 SLNIVYRDLKPENILLDSQGHIVLTDFGLC--KENIEHNSTTSTFCGTPEYLAPEVLHKQ 272
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 114 bits (284), Expect = 3e-25 Identities = 59/182 (32%), Positives = 108/182 (59%), Gaps = 3/182 (1%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P+ +E +K+LG+G+F KV+L R + D A+KV+ K L K+ + K E ++ Sbjct: 59 PSHFELLKVLGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATL-KVRDRVRTKMERDILA 117 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 + HP +V+LH + +++++++++RGG L+ + E++ + +L L Sbjct: 118 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFA 585 H+ G+ +RD+KP+N+L+DE G++K+ DFGLS A ++A ++ CGT Y+ PEV Sbjct: 178 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA--YSFCGTVEYMAPEVVN 235 Query: 586 RR 591 R+ Sbjct: 236 RQ 237 Score = 88.6 bits (218), Expect = 1e-17 Identities = 59/175 (33%), Positives = 86/175 (49%), Gaps = 5/175 (2%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHPNIVQLH 258 +G G+++ H T E A+KV+DK K + EI ++ R +HPNI+ L Sbjct: 424 IGVGSYSVCKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQHPNIITLK 476 Query: 259 KVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 V +++V E +RGG L I E E + + + + H+QGV HRD+ Sbjct: 477 DVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDL 536 Query: 439 KPDNLL-VDEHGN---LKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 KP N+L VDE GN L++ DFG + LL T C T +V PEV R+ Sbjct: 537 KPSNILYVDESGNPECLRICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKRQ 589
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 114 bits (284), Expect = 3e-25 Identities = 68/208 (32%), Positives = 111/208 (53%), Gaps = 36/208 (17%) Frame = +1 Query: 76 KLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLI----KLGAVQQ--------------- 198 K LG+G+ +V LA++M+T + AIK++ K+K G V Sbjct: 85 KTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPS 144 Query: 199 ----------------IKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRH 330 I+REI +M+ + H N++ L +V KS +++V+EYV GG L+ + Sbjct: 145 IASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDY 204 Query: 331 IPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVD-EHGNLKVADFGLSAH 507 + + G L E E F+Q+V +++CH+ + HRD+KP+NLL+D ++ +K+ADFG++A Sbjct: 205 LVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAA- 263 Query: 508 ADTARREALLHTVCGTPLYVPPEVFARR 591 LL T CG+P Y PE+ R Sbjct: 264 --LELPNKLLKTSCGSPHYASPEIVMGR 289
>SGK1_RAT (Q06226) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 430 Score = 114 bits (284), Expect = 3e-25 Identities = 57/180 (31%), Positives = 101/180 (56%), Gaps = 1/180 (0%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRL 231 P+ + +K++G+G+F KV LARH + A+KV+ K+ ++K + I E V+ + + Sbjct: 95 PSDFHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 154 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 +HP +V LH +++ V++Y+ GG L+ H+ E R ++ SAL + H Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 + + +RD+KP+N+L+D G++ + DFGL + T CGTP Y+ PEV ++ Sbjct: 215 SLNIVYRDLKPENILLDSQGHIVLTDFGLC--KENIEHNGTTSTFCGTPEYLAPEVLHKQ 272
>SGK1_MOUSE (Q9WVC6) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 113 bits (283), Expect = 4e-25 Identities = 57/180 (31%), Positives = 101/180 (56%), Gaps = 1/180 (0%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRL 231 P+ + +K++G+G+F KV LARH + A+KV+ K+ ++K + I E V+ + + Sbjct: 95 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 154 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 +HP +V LH +++ V++Y+ GG L+ H+ E R ++ SAL + H Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 + + +RD+KP+N+L+D G++ + DFGL + T CGTP Y+ PEV ++ Sbjct: 215 SLNIVYRDLKPENILLDSQGHIVLTDFGLC--KENIEHNGTTSTFCGTPEYLAPEVLHKQ 272
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 113 bits (283), Expect = 4e-25 Identities = 60/176 (34%), Positives = 102/176 (57%), Gaps = 3/176 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQ 252 +++LG G F++V+L + T + A+K + K + +++ EIAV++R++H NIV Sbjct: 26 MEVLGSGAFSEVFLVKQRVTGKLFALKCIKKSPAFRDSSLEN---EIAVLKRIKHENIVT 82 Query: 253 LHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHR 432 L + + ++VM+ V GG L+ I G E + + QQ++SA+ + H G+ HR Sbjct: 83 LEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142 Query: 433 DIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 D+KP+NLL +E+ + + DFGLS + ++ T CGTP YV PEV A++ Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLS----KMEQNGVMSTACGTPGYVAPEVLAQK 194
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 113 bits (283), Expect = 4e-25 Identities = 61/182 (33%), Positives = 102/182 (56%), Gaps = 10/182 (5%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKE-EVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 + + L+G G FA V+ RH + + EVA+K ++K+ L K + + +EI +++ L+H Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL--LGKEIKILKELKHE 73 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV L+ + +++VMEY GG L ++ L ED R QQ+ A+ H++G Sbjct: 74 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKG 133 Query: 421 VYHRDIKPDNLLVDEHG---------NLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 + HRD+KP N+L+ G +K+ADFG + + + A T+CG+P+Y+ P Sbjct: 134 IIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAA---TLCGSPMYMAP 190 Query: 574 EV 579 EV Sbjct: 191 EV 192
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 113 bits (283), Expect = 4e-25 Identities = 60/176 (34%), Positives = 102/176 (57%), Gaps = 3/176 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQ 252 +++LG G F++V+L + T + A+K + K + +++ EIAV++R++H NIV Sbjct: 26 MEVLGSGAFSEVFLVKQRVTGKLFALKCIKKSPAFRDSSLEN---EIAVLKRIKHENIVT 82 Query: 253 LHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHR 432 L + + ++VM+ V GG L+ I G E + + QQ++SA+ + H G+ HR Sbjct: 83 LEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142 Query: 433 DIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 D+KP+NLL +E+ + + DFGLS + ++ T CGTP YV PEV A++ Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLS----KMEQNGVMSTACGTPGYVAPEVLAQK 194
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 113 bits (283), Expect = 4e-25 Identities = 65/181 (35%), Positives = 104/181 (57%), Gaps = 4/181 (2%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGA----VQQIKREIAVMRR 228 +Y ++++GEG+F +VY R + + VA+K + K LG ++ ++REI +MR Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPK-----LGRSEKELRNLQREIEIMRG 57 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFC 408 LRHPNIV + + VV +Y G L + + +G L ED+ + I QLVSAL + Sbjct: 58 LRHPNIVHMLDSFETDKEVVVVTDYAEG-ELLQILEDDGKLPEDQVQAIAAQLVSALYYL 116 Query: 409 HAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 H+ + HRD+KP N+L+ + G +K+ DFG + T +L ++ GTPLY+ PE+ Sbjct: 117 HSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMST--NTMVLTSIKGTPLYMSPELVEE 174 Query: 589 R 591 R Sbjct: 175 R 175
>KPCE_RABIT (P10830) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 736 Score = 113 bits (283), Expect = 4e-25 Identities = 70/198 (35%), Positives = 107/198 (54%), Gaps = 9/198 (4%) Frame = +1 Query: 13 PRSGDGAMGDRPKLPA-RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK--- 180 P +G+ G +L + +K+LG+G+F KV LA E A+KV+ K+ +++ Sbjct: 389 PENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDD 448 Query: 181 LGAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKED 360 + KR +A+ R+ HP + QL+ K R+F VMEYV GG L I + E Sbjct: 449 VDCTMTEKRILALARK--HPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEP 506 Query: 361 ETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH 540 +R ++ SAL F H GV +RD+K DN+L+D G+ K+ADFG+ +E +L+ Sbjct: 507 RSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC-------KEGILN 559 Query: 541 -----TVCGTPLYVPPEV 579 T CGTP Y+ PE+ Sbjct: 560 GVTTTTFCGTPDYIAPEI 577
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 113 bits (282), Expect = 5e-25 Identities = 64/186 (34%), Positives = 106/186 (56%), Gaps = 4/186 (2%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMD-KEKLIKLGAVQQIKREIAVM 222 P++ ARY+ L+G G+F++V TK+ AIKVM+ +E+ + V E++V+ Sbjct: 57 PRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVS----ELSVL 112 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 RR+ H IVQL ++ + ++++VME GG L+ + A G E + RI Q + + Sbjct: 113 RRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIR 172 Query: 403 FCHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 + HA + HR++KP+NLL E + + DFGL A++ + + T+CGTP Y+ P Sbjct: 173 YLHALQITHRNLKPENLLYYHPGEESKILITDFGL-AYSGKKSGDWTMKTLCGTPEYIAP 231 Query: 574 EVFARR 591 EV R+ Sbjct: 232 EVLLRK 237
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 112 bits (281), Expect = 6e-25 Identities = 65/177 (36%), Positives = 100/177 (56%), Gaps = 11/177 (6%) Frame = +1 Query: 82 LGEGNFAKVYLA----------RHMDTKEEVAIKVMDKEKLIKLGAVQ-QIKREIAVMRR 228 LGEG F KV L D ++VAIK++ ++ + + +I REI ++ Sbjct: 47 LGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKH 106 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFC 408 L HPNIV+L +V+ I +V+EY GG Y++I LKE R+F QL+S + + Sbjct: 107 LSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYI 166 Query: 409 HAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 H++G+ HRD+K +NLL+D++ NL + DFG + R L+ T CG+P Y PE+ Sbjct: 167 HSKGLVHRDLKLENLLLDKNENLVITDFGFV--NEFCSRNELMKTSCGSPCYAAPEL 221
>KPCL_RAT (Q64617) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 112 bits (281), Expect = 6e-25 Identities = 63/173 (36%), Positives = 98/173 (56%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLR-HP 240 +E +++LG+G+F KV LAR +T E A+KV+ K+ +++ V+ E ++ R HP Sbjct: 355 FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 414 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 + QL R+F VME+V GG L HI + E R +++SAL F H +G Sbjct: 415 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKG 474 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+K DN+L+D G+ K+ADFG+ + T CGTP Y+ PE+ Sbjct: 475 IIYRDLKLDNVLLDHEGHCKLADFGMC--KEGICNGVTTATFCGTPDYIAPEI 525
>KPCL_MOUSE (P23298) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 112 bits (281), Expect = 6e-25 Identities = 63/173 (36%), Positives = 98/173 (56%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLR-HP 240 +E +++LG+G+F KV LAR +T E A+KV+ K+ +++ V+ E ++ R HP Sbjct: 355 FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 414 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 + QL R+F VME+V GG L HI + E R +++SAL F H +G Sbjct: 415 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKG 474 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+K DN+L+D G+ K+ADFG+ + T CGTP Y+ PE+ Sbjct: 475 IIYRDLKLDNVLLDHEGHCKLADFGMC--KEGICNGVTTATFCGTPDYIAPEI 525
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 112 bits (281), Expect = 6e-25 Identities = 68/205 (33%), Positives = 108/205 (52%), Gaps = 18/205 (8%) Frame = +1 Query: 19 SGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVM-----DKEKLIKL 183 S D +R K+ Y K +G G+ KV +A H+ T E+ AIK++ D K Sbjct: 110 SADEKPRERRKVIGNYVLGKTIGAGSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAA 169 Query: 184 GAVQQIK-------------REIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLY 324 + + K RE A+ LRHP I + V S ++V E+V GG + Sbjct: 170 ASAEATKAAQSEKNKEIRTVREAALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQML 229 Query: 325 RHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSA 504 +I ++G LKE + R+ +Q+ SAL++ H V HRD+K +N+L+ + G++K+ DFGLS Sbjct: 230 DYIISHGKLKEKQARKFVRQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLS- 288 Query: 505 HADTARREALLHTVCGTPLYVPPEV 579 + RR++ L T CG+ + PE+ Sbjct: 289 --NLYRRQSRLRTFCGSLYFAAPEL 311
>AKT1_RAT (P47196) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) Length = 480 Score = 112 bits (280), Expect = 8e-25 Identities = 62/173 (35%), Positives = 95/173 (54%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +KLLG+G F KV L + T A+K++ KE ++ V E V++ RHP Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ-G 420 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V +RD+K +NL++D+ G++K+ DFGL + + A + T CGTP Y+ PEV Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEV 320
>AKT1_MOUSE (P31750) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto-oncogene) Length = 480 Score = 112 bits (280), Expect = 8e-25 Identities = 62/173 (35%), Positives = 95/173 (54%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +KLLG+G F KV L + T A+K++ KE ++ V E V++ RHP Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ-G 420 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V +RD+K +NL++D+ G++K+ DFGL + + A + T CGTP Y+ PEV Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEV 320
>AKT1_HUMAN (P31749) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT) Length = 480 Score = 112 bits (280), Expect = 8e-25 Identities = 62/173 (35%), Positives = 95/173 (54%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +KLLG+G F KV L + T A+K++ KE ++ V E V++ RHP Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ-G 420 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V +RD+K +NL++D+ G++K+ DFGL + + A + T CGTP Y+ PEV Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEV 320
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 112 bits (280), Expect = 8e-25 Identities = 61/182 (33%), Positives = 102/182 (56%), Gaps = 10/182 (5%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKE-EVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHP 240 + + L+G G FA V+ RH + + EVA+K ++K+ L K + + +EI +++ L+H Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL--LGKEIKILKELKHE 73 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV L+ + +++VMEY GG L ++ A L ED R QQ+ A+ H++G Sbjct: 74 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKG 133 Query: 421 VYHRDIKPDNLLVDEHG---------NLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 + HRD+KP N+L+ +K+ADFG + + + A T+CG+P+Y+ P Sbjct: 134 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAA---TLCGSPMYMAP 190 Query: 574 EV 579 EV Sbjct: 191 EV 192
>AKT_MLVAT (P31748) AKT kinase transforming protein (EC 2.7.11.1)| Length = 501 Score = 112 bits (280), Expect = 8e-25 Identities = 62/173 (35%), Positives = 95/173 (54%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +KLLG+G F KV L + T A+K++ KE ++ V E V++ RHP Sbjct: 171 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 230 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ-G 420 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ Sbjct: 231 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 290 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V +RD+K +NL++D+ G++K+ DFGL + + A + T CGTP Y+ PEV Sbjct: 291 VVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEV 341
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 112 bits (280), Expect = 8e-25 Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 3/176 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQ 252 +++LG G F++V+L + T + A+K + K + +++ EIAV+++++H NIV Sbjct: 26 MEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLEN---EIAVLKKIKHENIVT 82 Query: 253 LHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHR 432 L + + ++VM+ V GG L+ I G E + + QQ++SA+ + H G+ HR Sbjct: 83 LEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142 Query: 433 DIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 D+KP+NLL +E+ + + DFGLS + ++ T CGTP YV PEV A++ Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLS----KMEQNGIMSTACGTPGYVAPEVLAQK 194
>ST32B_HUMAN (Q9NY57) Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2)| Length = 414 Score = 112 bits (280), Expect = 8e-25 Identities = 58/173 (33%), Positives = 100/173 (57%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ ++ +G+G+F KV + + DTK+ A+K M+K+K I+ V+ + RE+ +M+ L HP Sbjct: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPF 82 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V L + +F+V++ + GG L H+ N E + +L AL + + Sbjct: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHI 142 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 HRDIKPDN+L+DEHG++ + DF ++ A R + ++ GT Y+ PEVF Sbjct: 143 IHRDIKPDNILLDEHGHVHITDFNIATVVKGAERAS---SMAGTKPYMAPEVF 192
>AKT1_XENLA (Q98TY9) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase Akt-1) (Protein kinase B, alpha) (PKB alpha) (xAkt) Length = 481 Score = 112 bits (279), Expect = 1e-24 Identities = 62/173 (35%), Positives = 95/173 (54%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E +KLLG+G F KV L + T A+K++ KE ++ V E V++ RHP Sbjct: 151 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 210 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQ-G 420 + L R+ VMEY GG L+ H+ ED R ++VSAL + H++ Sbjct: 211 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERIFSEDRARFYGAEIVSALDYLHSEKN 270 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V +RD+K +NL++D+ G++K+ DFGL + + A + T CGTP Y+ PEV Sbjct: 271 VVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEV 321
>KKCC2_MOUSE (Q8C078) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 111 bits (278), Expect = 1e-24 Identities = 65/190 (34%), Positives = 106/190 (55%), Gaps = 25/190 (13%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKL-----------------------GAV 192 +G+G++ V LA + + A+KV+ K+KLI+ G + Sbjct: 171 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGARPAPGGCIQPRGPI 230 Query: 193 QQIKREIAVMRRLRHPNIVQLHKVM--ACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 +Q+ +EIA++++L HPN+V+L +V+ + +++V E V GP+ +P L ED+ Sbjct: 231 EQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQA 289 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTV 546 R FQ L+ + + H Q + HRDIKP NLLV E G++K+ADFG+S + +ALL Sbjct: 290 RFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS--NEFKGSDALLSNT 347 Query: 547 CGTPLYVPPE 576 GTP ++ PE Sbjct: 348 VGTPAFMAPE 357
>KKCC2_HUMAN (Q96RR4) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 111 bits (278), Expect = 1e-24 Identities = 65/190 (34%), Positives = 106/190 (55%), Gaps = 25/190 (13%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKL-----------------------GAV 192 +G+G++ V LA + + A+KV+ K+KLI+ G + Sbjct: 171 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 230 Query: 193 QQIKREIAVMRRLRHPNIVQLHKVM--ACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 +Q+ +EIA++++L HPN+V+L +V+ + +++V E V GP+ +P L ED+ Sbjct: 231 EQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQA 289 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTV 546 R FQ L+ + + H Q + HRDIKP NLLV E G++K+ADFG+S + +ALL Sbjct: 290 RFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS--NEFKGSDALLSNT 347 Query: 547 CGTPLYVPPE 576 GTP ++ PE Sbjct: 348 VGTPAFMAPE 357
>KKCC2_RAT (O88831) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 587 Score = 111 bits (278), Expect = 1e-24 Identities = 65/190 (34%), Positives = 106/190 (55%), Gaps = 25/190 (13%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKL-----------------------GAV 192 +G+G++ V LA + + A+KV+ K+KLI+ G + Sbjct: 170 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 229 Query: 193 QQIKREIAVMRRLRHPNIVQLHKVM--ACKSRIFVVMEYVRGGPLYRHIPANGGLKEDET 366 +Q+ +EIA++++L HPN+V+L +V+ + +++V E V GP+ +P L ED+ Sbjct: 230 EQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQA 288 Query: 367 RRIFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTV 546 R FQ L+ + + H Q + HRDIKP NLLV E G++K+ADFG+S + +ALL Sbjct: 289 RFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS--NEFKGSDALLSNT 346 Query: 547 CGTPLYVPPE 576 GTP ++ PE Sbjct: 347 VGTPAFMAPE 356
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 111 bits (278), Expect = 1e-24 Identities = 64/181 (35%), Positives = 104/181 (57%), Gaps = 4/181 (2%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGA----VQQIKREIAVMRR 228 +Y ++++GEG+F +VY R + + VA+K + K LG ++ ++REI +MR Sbjct: 3 KYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPK-----LGRSEKELRNLQREIEIMRG 57 Query: 229 LRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFC 408 L HPNIV + + VV +Y G L++ + +G L ED+ + I QLVSAL + Sbjct: 58 LWHPNIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYL 116 Query: 409 HAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 H+ + HRD+KP N+L+ + G +K+ DFG + T +L ++ GTPLY+ PE+ Sbjct: 117 HSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMST--NTMVLTSIKGTPLYMSPELVEE 174 Query: 589 R 591 R Sbjct: 175 R 175
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 111 bits (277), Expect = 2e-24 Identities = 63/175 (36%), Positives = 96/175 (54%), Gaps = 1/175 (0%) Frame = +1 Query: 58 ARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-R 234 A + VK++G+G+F KV LA T E A+KV+ K+ +I+ ++ E ++ R Sbjct: 369 ADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGR 428 Query: 235 HPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHA 414 P +V +H R+F VMEY +GG L H+ G KE ++ AL F H Sbjct: 429 PPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHE 488 Query: 415 QGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + + +RD+K DN+L+D G++K+ DFGLS T R+ T CGTP Y+ PE+ Sbjct: 489 RDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTT--RTFCGTPNYMAPEI 541
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 111 bits (277), Expect = 2e-24 Identities = 56/177 (31%), Positives = 103/177 (58%), Gaps = 1/177 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E + LG+G F KVY RH + A+K ++K ++++ ++Q+KRE+ + + HPN Sbjct: 100 FEVGRKLGKGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQLGMDHPN 159 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I++L+ + R++++ME+ G LY+ + NG + Q+ AL + H + + Sbjct: 160 IIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGPFNDVLASHYIYQIADALHYMHKKRI 219 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLS-AHADTARREALLHTVCGTPLYVPPEVFARR 591 HRD+KP+N+L+ +K+ADFG S + + ++R+ T+CGT Y+ PE+ R Sbjct: 220 IHRDVKPENVLIGFDNVVKLADFGWSILNPEGSKRK----TLCGTIDYLSPEMITPR 272
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 110 bits (276), Expect = 2e-24 Identities = 66/177 (37%), Positives = 99/177 (55%), Gaps = 8/177 (4%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK---LGAVQQIKREIAVMRRLRHPN 243 +K+LG+G+F KV LA E A+KV+ K+ +++ + KR +A+ R+ HP Sbjct: 411 IKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARK--HPY 468 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + QL+ K R+F VMEYV GG L I + E +R ++ SAL F H GV Sbjct: 469 LTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGV 528 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH-----TVCGTPLYVPPEV 579 +RD+K DN+L+D G+ K+ADFG+ +E +L+ T CGTP Y+ PE+ Sbjct: 529 IYRDLKLDNILLDAEGHCKLADFGMC-------KEGILNGVTTTTFCGTPDYIAPEI 578
>KPC3_CAEEL (Q19266) Protein kinase C-like 3 (EC 2.7.11.13) (Atypical protein| kinase C-3) (aPKC3) Length = 597 Score = 110 bits (276), Expect = 2e-24 Identities = 57/173 (32%), Positives = 100/173 (57%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 + + ++G G++AKV A H+ T++ AIK++ KE + + ++ E +V +P Sbjct: 253 FRLLTVIGRGSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYP 312 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V LH +SR+F V+E+V GG L H+ L E+ R +++ AL F H++G Sbjct: 313 FLVGLHSCFQTESRLFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRG 372 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+K DN+L+D G++K+ D+G+ + + L T CGTP Y+ PE+ Sbjct: 373 IIYRDLKLDNVLIDAEGHIKLTDYGMC--KENIKDGDLTSTFCGTPNYIAPEI 423
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 110 bits (276), Expect = 2e-24 Identities = 52/172 (30%), Positives = 99/172 (57%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ +K +G G F +V L R +++ A+K++ ++I+L ++ +K E ++R +RHP Sbjct: 274 YQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPF 333 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 ++ L S ++++ +YV GG L+ ++ G + ++VSAL + H+ + Sbjct: 334 VISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQI 393 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+KP+NLL++ G+LK+ DFG + + T+CGTP Y+ PE+ Sbjct: 394 VYRDLKPENLLINRDGHLKITDFGFA-----KKLRDRTWTLCGTPEYIAPEI 440
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 110 bits (275), Expect = 3e-24 Identities = 51/176 (28%), Positives = 100/176 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ ++ LG G+F +V+L R + AIKV+ K++++K+ V+ E +++ + HP Sbjct: 70 FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPF 129 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 ++++ IF+VM+Y+ GG L+ + + + +++ AL + HA + Sbjct: 130 LIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNI 189 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 +RD+KP+N+L+D +G++K+ DFG + T + T+CGTP Y+ PEV + Sbjct: 190 IYRDLKPENILLDRNGHIKITDFGFAKEVQT-----VTWTLCGTPDYIAPEVITTK 240
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 110 bits (274), Expect = 4e-24 Identities = 57/176 (32%), Positives = 105/176 (59%), Gaps = 3/176 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +K+LG+G+F KV+L R + D + A+KV+ K L K+ + K E ++ + HP Sbjct: 65 LKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATL-KVRDRVRTKMERDILADVHHPF 123 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+LH + +++++++++RGG L+ + E++ + +L L H+ G+ Sbjct: 124 VVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 183 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 +RD+KP+N+L+DE G++K+ DFGLS A ++A ++ CGT Y+ PEV R+ Sbjct: 184 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA--YSFCGTVEYMAPEVVNRQ 237 Score = 89.4 bits (220), Expect = 7e-18 Identities = 61/181 (33%), Positives = 90/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 Y + +G G+++ H T E A+KV+DK K + EI ++RR +HP Sbjct: 416 YTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKSK-------RDPSEEIEILRRYGQHP 468 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V + I++V E +RGG L I E E + + + + H+QG Sbjct: 469 NIITLKDVYEECNSIYLVTELMRGGELLDRILRQKFFSEREACSVLFTVCKTVEYLHSQG 528 Query: 421 VYHRDIKPDNLL-VDEHG---NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE G ++++ DFG S LL T C T +V PEV R Sbjct: 529 VVHRDLKPSNILYVDESGDPESIRICDFGFS--KQLRAENGLLMTPCYTANFVAPEVLKR 586 Query: 589 R 591 + Sbjct: 587 Q 587
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 110 bits (274), Expect = 4e-24 Identities = 64/172 (37%), Positives = 95/172 (55%), Gaps = 3/172 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK---LGAVQQIKREIAVMRRLRHPN 243 +K+LG+G+F KV LA E A+KV+ K+ +++ + KR +A+ R+ HP Sbjct: 411 IKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARK--HPY 468 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + QL+ K R+F VMEYV GG L I + E +R ++ SAL F H GV Sbjct: 469 LTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGV 528 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K DN+L+D G+ K+ADFG+ + T CGTP Y+ PE+ Sbjct: 529 IYRDLKLDNILLDAEGHCKLADFGMC--KEGIMNGVTTTTFCGTPDYIAPEI 578
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 110 bits (274), Expect = 4e-24 Identities = 57/176 (32%), Positives = 105/176 (59%), Gaps = 3/176 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHM---DTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +K+LG+G+F KV+L R + D + A+KV+ K L K+ + K E ++ + HP Sbjct: 65 LKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATL-KVRDRVRTKMERDILADVHHPF 123 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V+LH + +++++++++RGG L+ + E++ + +L L H+ G+ Sbjct: 124 VVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 183 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 +RD+KP+N+L+DE G++K+ DFGLS A ++A ++ CGT Y+ PEV R+ Sbjct: 184 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA--YSFCGTVEYMAPEVVNRQ 237 Score = 87.0 bits (214), Expect = 4e-17 Identities = 61/181 (33%), Positives = 89/181 (49%), Gaps = 5/181 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 Y + +G G+++ H T E A+KV+DK K + EI ++RR +HP Sbjct: 416 YTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTK-------RDPSEEIEILRRYGQHP 468 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NI+ L V + I+VV E +RGG L I E E + + + H+QG Sbjct: 469 NIIALKDVYKEGNSIYVVTELMRGGELLDRILRQKFFSEREASSVLFTVCKTVENLHSQG 528 Query: 421 VYHRDIKPDNLL-VDEHG---NLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP N+L VDE G ++++ DFG + LL T C T +V PEV R Sbjct: 529 VVHRDLKPSNILYVDESGDPESIRICDFGFA--KQLRADNGLLMTPCYTANFVAPEVLKR 586 Query: 589 R 591 + Sbjct: 587 Q 587
>KPCL_HUMAN (P24723) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 682 Score = 110 bits (274), Expect = 4e-24 Identities = 62/173 (35%), Positives = 97/173 (56%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLR-HP 240 +E +++LG+G+F KV LAR +T + A+KV+ K+ ++ V+ E ++ R HP Sbjct: 354 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILLDDDVECTMTEKRILSLARNHP 413 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 + QL R+F VME+V GG L HI + E R +++SAL F H +G Sbjct: 414 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKG 473 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+K DN+L+D G+ K+ADFG+ + T CGTP Y+ PE+ Sbjct: 474 IIYRDLKLDNVLLDHEGHCKLADFGMC--KEGICNGVTTATFCGTPDYIAPEI 524
>TSSK3_MOUSE (Q9D2E1) Testis-specific serine/threonine-protein kinase 3 (EC| 2.7.11.1) (TSSK-3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C) Length = 268 Score = 110 bits (274), Expect = 4e-24 Identities = 62/173 (35%), Positives = 103/173 (59%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 Y+ K +GEG ++KV A + +VAIK++DK + + + RE+ ++R L H N Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69 Query: 244 IVQLHKVM-ACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 I+Q+++++ + +I++VME GG ++ + G L E + +F+Q+V A+ +CH G Sbjct: 70 IIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 V HRD+K +N L+ + NLK+ DFG + +RRE L T CG+ Y PEV Sbjct: 130 VAHRDLKCENALL-QGFNLKLTDFGFAKVLPKSRRE-LSQTFCGSTAYAAPEV 180
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 110 bits (274), Expect = 4e-24 Identities = 66/183 (36%), Positives = 100/183 (54%), Gaps = 1/183 (0%) Frame = +1 Query: 40 DRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAV 219 DR KL + + +LG+G+F KV LA T+E AIK++ K+ +I+ V+ E V Sbjct: 331 DRVKL-TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRV 389 Query: 220 MRRL-RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSA 396 + L + P + QLH R++ VMEYV GG L HI G KE + ++ Sbjct: 390 LALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIG 449 Query: 397 LTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 L F H +G+ +RD+K DN+++D G++K+ADFG+ + T CGTP Y+ PE Sbjct: 450 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC--KEHMMDGVTTRTFCGTPDYIAPE 507 Query: 577 VFA 585 + A Sbjct: 508 IIA 510
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 110 bits (274), Expect = 4e-24 Identities = 66/183 (36%), Positives = 100/183 (54%), Gaps = 1/183 (0%) Frame = +1 Query: 40 DRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAV 219 DR KL + + +LG+G+F KV LA T+E AIK++ K+ +I+ V+ E V Sbjct: 331 DRVKL-TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRV 389 Query: 220 MRRL-RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSA 396 + L + P + QLH R++ VMEYV GG L HI G KE + ++ Sbjct: 390 LALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIG 449 Query: 397 LTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 L F H +G+ +RD+K DN+++D G++K+ADFG+ + T CGTP Y+ PE Sbjct: 450 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC--KEHMMDGVTTRTFCGTPDYIAPE 507 Query: 577 VFA 585 + A Sbjct: 508 IIA 510
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 110 bits (274), Expect = 4e-24 Identities = 66/183 (36%), Positives = 100/183 (54%), Gaps = 1/183 (0%) Frame = +1 Query: 40 DRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAV 219 DR KL + + +LG+G+F KV LA T+E AIK++ K+ +I+ V+ E V Sbjct: 331 DRVKL-TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRV 389 Query: 220 MRRL-RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSA 396 + L + P + QLH R++ VMEYV GG L HI G KE + ++ Sbjct: 390 LALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIG 449 Query: 397 LTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPE 576 L F H +G+ +RD+K DN+++D G++K+ADFG+ + T CGTP Y+ PE Sbjct: 450 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC--KEHMMDGVTTRTFCGTPDYIAPE 507 Query: 577 VFA 585 + A Sbjct: 508 IIA 510
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 109 bits (273), Expect = 5e-24 Identities = 67/185 (36%), Positives = 102/185 (55%), Gaps = 3/185 (1%) Frame = +1 Query: 40 DRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQI---KRE 210 DR KL + + +LG+G+F KV LA T+E AIK++ K+ +I+ V+ KR Sbjct: 331 DRVKL-TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRV 389 Query: 211 IAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLV 390 +A+M + P + QLH R++ VMEYV GG L HI G KE + ++ Sbjct: 390 LALMDK--PPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIS 447 Query: 391 SALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP 570 L F H +G+ +RD+K DN+++D G++K+ADFG+ + T CGTP Y+ Sbjct: 448 IGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC--KEHMMDGVTTRTFCGTPDYIA 505 Query: 571 PEVFA 585 PE+ A Sbjct: 506 PEIIA 510
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 109 bits (272), Expect = 7e-24 Identities = 65/183 (35%), Positives = 98/183 (53%), Gaps = 3/183 (1%) Frame = +1 Query: 40 DRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAV 219 +R L +E LG G + VY + T++ A+KV+ K K+ ++ EI V Sbjct: 34 NRDPLGDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGV 88 Query: 220 MRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSAL 399 + RL HPNI++L ++ + I +V+E V GG L+ I G E + R +Q++ A+ Sbjct: 89 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAV 148 Query: 400 TFCHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP 570 + H G+ HRD+KP+NLL LK+ADFGLS + L+ TVCGTP Y Sbjct: 149 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLS---KIVEHQVLMKTVCGTPGYCA 205 Query: 571 PEV 579 PE+ Sbjct: 206 PEI 208
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 109 bits (272), Expect = 7e-24 Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 3/185 (1%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P RY + K+LG+G FAK Y + + A K++ ++ K ++I +EI + R Sbjct: 73 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHR 132 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 L H ++VQ + K I++++EY + + A L E E R +Q+VS L + Sbjct: 133 LLHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKY 192 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH---TVCGTPLYVPPE 576 H Q + HRD+K N ++E LKV DFGL+ AR E L H T+CGTP Y+ PE Sbjct: 193 LHEQEILHRDLKLGNFFINEAMELKVGDFGLA-----ARLEPLEHRRRTICGTPNYLSPE 247 Query: 577 VFARR 591 V ++ Sbjct: 248 VLNKQ 252
>ST32B_MOUSE (Q9JJX8) Serine/threonine-protein kinase 32B (EC 2.7.11.1)| Length = 414 Score = 109 bits (272), Expect = 7e-24 Identities = 56/173 (32%), Positives = 98/173 (56%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++ ++ +G+G+F KV + + DTK+ A+K M+K+K ++ V+ + RE+ +M+ L HP Sbjct: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCVERDEVRNVFRELQIMQGLEHPF 82 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 +V L + +F+V++ + GG L H+ N E + +L AL + + Sbjct: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHI 142 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVF 582 HRDIKPDN+L+DEHG++ + DF + A + ++ GT Y+ PEVF Sbjct: 143 IHRDIKPDNILLDEHGHVHITDFNI---ATVLKGSEKASSMAGTKPYMAPEVF 192
>SSP1_SCHPO (P50526) Serine/threonine-protein kinase ssp1 (EC 2.7.11.1)| Length = 652 Score = 108 bits (271), Expect = 9e-24 Identities = 66/184 (35%), Positives = 107/184 (58%), Gaps = 12/184 (6%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDK-EKLIKLGAV------QQIKREIAVM 222 YE +K LG G KV L R T+E +AIK++ K E+ KLG ++++REIA++ Sbjct: 135 YEIIKELGRGMHGKVKLGRDTVTRELLAIKIIPKTERRPKLGRANASSQKEKVRREIAIL 194 Query: 223 RRLRHPNIVQLHKVM--ACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSA 396 ++ HPN+V+L +V+ +++++V+EY+ GG + + L E R+ F+ +V Sbjct: 195 KKCVHPNVVRLREVIDDPSSTKVYLVLEYMSGGEVPWTDCDSPVLSISEARQYFRDVVLG 254 Query: 397 LTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARRE---ALLHTVCGTPLYV 567 L + H QG+ HRDIKP NLL++ +K++DFG+S A+ E L GTP + Sbjct: 255 LEYLHYQGIIHRDIKPANLLLNSSNCVKISDFGVSYIANAGLNEDNDVELAKTVGTPAFF 314 Query: 568 PPEV 579 PE+ Sbjct: 315 APEL 318
>KPC1_DROME (P05130) Protein kinase C, brain isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(BR)) Length = 679 Score = 108 bits (271), Expect = 9e-24 Identities = 61/171 (35%), Positives = 97/171 (56%), Gaps = 2/171 (1%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQ--QIKREIAVMRRLRHPNI 246 +K+LG+G+F KV LA ++E AIK++ K+ +I+ V+ I++ + + + P + Sbjct: 353 IKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGE-KPPFL 411 Query: 247 VQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVY 426 VQLH R+F VMEYV GG L I G KE ++ + L F H +G+ Sbjct: 412 VQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGIL 471 Query: 427 HRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K DN+L+D G++K+ADFG+ + + T CGTP Y+ PE+ Sbjct: 472 YRDLKLDNVLLDADGHVKIADFGMC--KENIVGDKTTKTFCGTPDYIAPEI 520
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 108 bits (271), Expect = 9e-24 Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 3/185 (1%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P RY + K+LG+G FAK Y + + A K++ ++ K ++I +EI + R Sbjct: 73 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHR 132 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 L H ++VQ + K I++++EY + + A L E E R +Q+VS L + Sbjct: 133 ILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKY 192 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH---TVCGTPLYVPPE 576 H Q + HRD+K N ++E LKV DFGL+ AR E L H T+CGTP Y+ PE Sbjct: 193 LHEQEILHRDLKLGNFFINEAMELKVGDFGLA-----ARLEPLEHRRRTICGTPNYLSPE 247 Query: 577 VFARR 591 V ++ Sbjct: 248 VLNKQ 252
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 108 bits (271), Expect = 9e-24 Identities = 56/179 (31%), Positives = 106/179 (59%), Gaps = 6/179 (3%) Frame = +1 Query: 61 RYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMD-KEKLIKLGAVQQIK----REIAVMR 225 +Y+ ++G G + V H T +E A+K+M+ + + L +++++ RE+ ++R Sbjct: 23 KYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILR 82 Query: 226 RLR-HPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 ++ HP+I+ L S +F+V + +R G L+ ++ L E ETR I + L+ A++ Sbjct: 83 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 142 Query: 403 FCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 F HA + HRD+KP+N+L+D++ ++++DFG S H + + L +CGTP Y+ PE+ Sbjct: 143 FLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEK---LRELCGTPGYLAPEI 198
>TSSK2_HUMAN (Q96PF2) Testis-specific serine/threonine-protein kinase 2 (EC| 2.7.11.1) (TSSK-2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G) Length = 358 Score = 108 bits (271), Expect = 9e-24 Identities = 60/169 (35%), Positives = 98/169 (57%), Gaps = 3/169 (1%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 LG+G++AKV A K VA+K++D++K + + RE+ ++ + H +I++ ++ Sbjct: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77 Query: 262 VMACKS-RIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHRDI 438 + RI+++ME G L I G L ED R++F+QL SA+ +CH + HRD+ Sbjct: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137 Query: 439 KPDNLLVDEHGNLKVADFGLSAHA--DTARREALLHTVCGTPLYVPPEV 579 K +NLL+D+ N+K++DFG S D+ R L T CG+ Y PEV Sbjct: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEV 186
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 108 bits (271), Expect = 9e-24 Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 3/185 (1%) Frame = +1 Query: 46 PKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR 225 P RY + K+LG+G FAK Y + + A K++ ++ K ++I +EI + R Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHR 135 Query: 226 RLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTF 405 L H ++VQ + K I++++EY + + A L E E R +Q+VS L + Sbjct: 136 ILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKY 195 Query: 406 CHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH---TVCGTPLYVPPE 576 H Q + HRD+K N ++E LKV DFGL+ AR E L H T+CGTP Y+ PE Sbjct: 196 LHEQEILHRDLKLGNFFINEAMELKVGDFGLA-----ARLEPLEHRRRTICGTPNYLSPE 250 Query: 577 VFARR 591 V ++ Sbjct: 251 VLNKQ 255
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 107 bits (268), Expect = 2e-23 Identities = 65/177 (36%), Positives = 98/177 (55%), Gaps = 8/177 (4%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIK---LGAVQQIKREIAVMRRLRHPN 243 +K+LG+G+F KV LA E A+KV+ K+ +++ + KR +A+ R+ HP Sbjct: 411 IKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARK--HPY 468 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 + QL+ K R+F VMEYV GG L I + E + ++ SAL F H GV Sbjct: 469 LTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSGFYAAEVTSALMFLHQHGV 528 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLH-----TVCGTPLYVPPEV 579 +RD+K DN+L+D G+ K+ADFG+ +E +L+ T CGTP Y+ PE+ Sbjct: 529 IYRDLKLDNILLDAEGHSKLADFGMC-------KEGILNGVTTTTFCGTPDYIAPEI 578
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 107 bits (268), Expect = 2e-23 Identities = 59/196 (30%), Positives = 109/196 (55%), Gaps = 4/196 (2%) Frame = +1 Query: 4 NARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKL 183 N++ R G +Y+ +K+LG+G+F +V L+R T E AIKV+ K+ + + Sbjct: 49 NSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRK 108 Query: 184 GAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDE 363 + + RE+ +++ L H NI++L++ + ++V + GG L+ I + E + Sbjct: 109 TDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEID 168 Query: 364 TRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVD----EHGNLKVADFGLSAHADTARREA 531 RI +Q++S +T+ H V HRD+KP+N+L++ E +K+ DFGLS H + +++ Sbjct: 169 AARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKK-- 226 Query: 532 LLHTVCGTPLYVPPEV 579 + GT Y+ P+V Sbjct: 227 -MKDKIGTAYYIAPDV 241
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 107 bits (267), Expect = 3e-23 Identities = 64/183 (34%), Positives = 97/183 (53%), Gaps = 3/183 (1%) Frame = +1 Query: 40 DRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAV 219 +R L +E LG G + VY + T++ A+KV+ K K+ ++ EI V Sbjct: 38 NRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGV 92 Query: 220 MRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSAL 399 + RL HPNI++L ++ + I +V+E V GG L+ I G E + +Q++ A+ Sbjct: 93 LLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 152 Query: 400 TFCHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVP 570 + H G+ HRD+KP+NLL LK+ADFGLS + L+ TVCGTP Y Sbjct: 153 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLS---KIVEHQVLMKTVCGTPGYCA 209 Query: 571 PEV 579 PE+ Sbjct: 210 PEI 212
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 107 bits (267), Expect = 3e-23 Identities = 65/193 (33%), Positives = 99/193 (51%) Frame = +1 Query: 13 PRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAV 192 P S G + P+ Y + +LLG+G FA+ Y A +T A+KV+ + ++ K Sbjct: 45 PTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQR 104 Query: 193 QQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRR 372 ++I EI + R L+H +IV+ I++ +E L A L E E R Sbjct: 105 EKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRY 164 Query: 373 IFQQLVSALTFCHAQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCG 552 +Q++S L + H +G+ HRD+K N + E+ LKV DFGL+A + E T+CG Sbjct: 165 YLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPP--EQRKKTICG 222 Query: 553 TPLYVPPEVFARR 591 TP YV PEV R+ Sbjct: 223 TPNYVAPEVLLRQ 235
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 107 bits (267), Expect = 3e-23 Identities = 59/196 (30%), Positives = 109/196 (55%), Gaps = 4/196 (2%) Frame = +1 Query: 4 NARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKL 183 N++ R G +Y+ +K+LG+G+F +V L++ T E AIKV+ K+ + + Sbjct: 49 NSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRK 108 Query: 184 GAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDE 363 Q + RE+ +++ L H NI++L++ + ++V + GG L+ I + E + Sbjct: 109 TDKQSLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVD 168 Query: 364 TRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVD----EHGNLKVADFGLSAHADTARREA 531 RI +Q++S +T+ H V HRD+KP+N+L++ E +K+ DFGLS H + +++ Sbjct: 169 AARIIKQVLSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKK-- 226 Query: 532 LLHTVCGTPLYVPPEV 579 + GT Y+ P+V Sbjct: 227 -MKDKIGTAYYIAPDV 241
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 107 bits (267), Expect = 3e-23 Identities = 59/196 (30%), Positives = 109/196 (55%), Gaps = 4/196 (2%) Frame = +1 Query: 4 NARPRSGDGAMGDRPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKL 183 N++ R G +Y+ +K+LG+G+F +V L++ T E AIKV+ K+ + + Sbjct: 49 NSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRK 108 Query: 184 GAVQQIKREIAVMRRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDE 363 Q + RE+ +++ L H NI++L++ + ++V + GG L+ I + E + Sbjct: 109 TDKQSLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVD 168 Query: 364 TRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVD----EHGNLKVADFGLSAHADTARREA 531 RI +Q++S +T+ H V HRD+KP+N+L++ E +K+ DFGLS H + +++ Sbjct: 169 AARIIKQVLSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKK-- 226 Query: 532 LLHTVCGTPLYVPPEV 579 + GT Y+ P+V Sbjct: 227 -MKDKIGTAYYIAPDV 241
>SGK2_HUMAN (Q9HBY8) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 427 Score = 107 bits (267), Expect = 3e-23 Identities = 56/179 (31%), Positives = 98/179 (54%), Gaps = 1/179 (0%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRL 231 P ++ +K++G+GN+ KV LA+ A+KV+ K+ ++K I E +V+ + + Sbjct: 92 PTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNV 151 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 RHP +V L +++ V++YV GG L+ H+ E R ++ SA+ + H Sbjct: 152 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLH 211 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 + + +RD+KP+N+L+D G++ + DFGL + E T CGTP Y+ PEV + Sbjct: 212 SLNIIYRDLKPENILLDCQGHVVLTDFGLC--KEGVEPEDTTSTFCGTPEYLAPEVLRK 268
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 107 bits (267), Expect = 3e-23 Identities = 59/169 (34%), Positives = 93/169 (55%), Gaps = 2/169 (1%) Frame = +1 Query: 79 LLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQ--QIKREIAVMRRLRHPNIVQ 252 +LG+G+F KV LA T E AIK++ K+ +I+ V+ I++ + + + P +VQ Sbjct: 325 VLGKGSFGKVVLAERKGTDELYAIKILKKDVIIQDDDVECTMIEKRVLALPD-KPPFLVQ 383 Query: 253 LHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYHR 432 LH R++ VMEYV GG L I G KE ++ L + H QG+ +R Sbjct: 384 LHSCFQTMDRLYFVMEYVNGGDLMYRIQQEGKFKEPVAAFYAAEIAIGLFYLHTQGIVYR 443 Query: 433 DIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 D+K DN+++D G++K+ADFG+ + + T CGTP Y+ PE+ Sbjct: 444 DLKLDNVMLDAEGHIKIADFGMC--KENIMGDKTTRTFCGTPDYIAPEI 490
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 107 bits (266), Expect = 3e-23 Identities = 57/172 (33%), Positives = 91/172 (52%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 +E K+LG+G KVY +H + A+KVM K+ LI L + +REI + L HP Sbjct: 148 FEIGKVLGKGKLGKVYCVKHKTSGYIAALKVMAKKDLIDLKLEKNFRREIEIQSNLIHPK 207 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 I +L+ +++++EY G LY H+ + Q+ AL + H + + Sbjct: 208 ISRLYGFFYDHKNVYLILEYSIHGELYHHLKVQRRFNDATASHYIYQVALALDYLHTKHI 267 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 HRDIKP+N+L+ +K++DFG S + + L T+CGT Y+PPE+ Sbjct: 268 IHRDIKPENILLSTDNCIKLSDFGWSVKSLPSSSTKRL-TICGTLDYLPPEM 318
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 107 bits (266), Expect = 3e-23 Identities = 64/182 (35%), Positives = 96/182 (52%), Gaps = 3/182 (1%) Frame = +1 Query: 43 RPKLPARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM 222 R L +E LG G + VY + T++ A+KV+ K K+ ++ EI V+ Sbjct: 35 RDPLSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGVL 89 Query: 223 RRLRHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALT 402 RL HPNI++L ++ + I +V+E V GG L+ I G E + +Q++ A+ Sbjct: 90 LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVA 149 Query: 403 FCHAQGVYHRDIKPDNLLV---DEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPP 573 + H G+ HRD+KP+NLL LK+ADFGLS + L+ TVCGTP Y P Sbjct: 150 YLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLS---KIVEHQVLMKTVCGTPGYCAP 206 Query: 574 EV 579 E+ Sbjct: 207 EI 208
>KAPC_ASCSU (P49673) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 337 Score = 107 bits (266), Expect = 3e-23 Identities = 50/176 (28%), Positives = 101/176 (57%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 ++++ +G G+F +VYL +H +++ A+K M +++ + + + E ++ RL HP Sbjct: 29 FDRICTIGTGSFGRVYLVQHRASEQYFALKKMAIREVVSMRQTEHVHSEKRLLSRLSHPF 88 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 IV+++ K ++++ EY+ GG L+ ++ A+ R ++V AL + H++ + Sbjct: 89 IVKMYCASWDKYNLYMLFEYLAGGELFSYLRASRTFSNSMARFYAAEIVCALQYLHSKNI 148 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFARR 591 +RD+KP+NL++++ G+LK+ DFG + T+CGTP Y+ PEV + Sbjct: 149 AYRDLKPENLMLNKEGHLKMTDFGFAKEVIDR-----TWTMCGTPEYLAPEVIGNK 199
>KPCI_BRARE (Q90XF2) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) Length = 588 Score = 107 bits (266), Expect = 3e-23 Identities = 58/173 (33%), Positives = 97/173 (56%), Gaps = 1/173 (0%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRL-RHP 240 ++ ++++G G++AKV L R T+ A+KV+ KE + + ++ E V + HP Sbjct: 246 FDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 305 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 +V LH +SR+F V+EYV GG L H+ L E+ R ++ AL + H +G Sbjct: 306 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG 365 Query: 421 VYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 + +RD+K DN+L+D G++K+ D+G+ + R T CGTP Y+ PE+ Sbjct: 366 IIYRDLKLDNVLLDSEGHIKLTDYGMC--KEGLRPGDTTSTFCGTPNYIAPEI 416
>KPC1B_CAEEL (P34885) Protein kinase C-like 1B (EC 2.7.11.13) (PKC1B)| Length = 707 Score = 107 bits (266), Expect = 3e-23 Identities = 60/170 (35%), Positives = 91/170 (53%), Gaps = 1/170 (0%) Frame = +1 Query: 73 VKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMR-RLRHPNIV 249 +K+LG+G+F KV LA T E AIK++ K+ +++ V+ E ++ +HP + Sbjct: 381 MKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLT 440 Query: 250 QLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGVYH 429 LH R+F VMEYV GG L I E R ++ AL F H V + Sbjct: 441 ALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIY 500 Query: 430 RDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 RD+K DN+L+D G+ ++ADFG+ + ++ L T CGTP Y+ PE+ Sbjct: 501 RDLKLDNILLDAEGHCRLADFGMC--KEGINKDNLTSTFCGTPDYIAPEI 548
>ATG1_USTMA (Q4P0K0) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 990 Score = 107 bits (266), Expect = 3e-23 Identities = 66/207 (31%), Positives = 104/207 (50%), Gaps = 41/207 (19%) Frame = +1 Query: 82 LGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPNIVQLHK 261 +G+G+FA V+ + +E VAIK++ ++KL + ++ EIA+++ + HPNIV+L + Sbjct: 21 IGKGSFAVVHKGYRLQPREPVAIKIVIRKKLTPK-LLDNLEGEIAILKAIHHPNIVELKE 79 Query: 262 VMACKSRIFVVMEYVRGGPLYRHI----------------------------PANGGLKE 357 + + +I++VM + G L ++I P +GGL E Sbjct: 80 CLKTEHQIYLVMAFCASGDLAQYIKKRFDIYERAGMAEPDSLTKGFKPTYPHPVDGGLNE 139 Query: 358 DETRRIFQQLVSALTFCHAQGVYHRDIKPDNLLVD-------------EHGNLKVADFGL 498 R I QL +AL F A+ + HRDIKP NLL+ E +KVADFG Sbjct: 140 TIVRSILTQLAAALEFMRARDIVHRDIKPQNLLLQPPDAAFLALGNPREIPQMKVADFGF 199 Query: 499 SAHADTARREALLHTVCGTPLYVPPEV 579 + H L T+CG+PLY+ PE+ Sbjct: 200 ARHLSV---NTLAETLCGSPLYMAPEI 223
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 106 bits (265), Expect = 4e-23 Identities = 56/185 (30%), Positives = 101/185 (54%), Gaps = 13/185 (7%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLRHPN 243 YE K++G G++ VY A + K VA+K++ K+K + + + REI VM+ LRH Sbjct: 25 YEVGKIIGHGSYGTVYEAYYTKQKVMVAVKIISKKKASEDYLNKFLPREIQVMKVLRHKY 84 Query: 244 IVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQGV 423 ++ ++ + SR+++++E +GG + I G E + F Q+ + + H++G+ Sbjct: 85 LINFYQAIETTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKGI 144 Query: 424 YHRDIKPDNLLVDEHGNLKVADFGLS--------AHADTARREA-----LLHTVCGTPLY 564 HRD+K +NLL+D+ N+K++DFG + H+ + R+ L T CG+ Y Sbjct: 145 VHRDLKLENLLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAY 204 Query: 565 VPPEV 579 PE+ Sbjct: 205 ACPEI 209
>KPC1_ASPNG (Q00078) Protein kinase C-like (EC 2.7.11.13)| Length = 1096 Score = 106 bits (265), Expect = 4e-23 Identities = 64/171 (37%), Positives = 96/171 (56%), Gaps = 4/171 (2%) Frame = +1 Query: 79 LLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKRE---IAVMRRLRHPNIV 249 +LG+GNF KV LA TK AIKV+ KE +I+ V+ K E + + RHP ++ Sbjct: 776 VLGKGNFGKVMLAETKSTKRLYAIKVLKKEFIIENDEVESTKSEKRVFMIANKERHPFLL 835 Query: 250 QLHKVMACKSRIFVVMEYVRGGPLYRHIPANG-GLKEDETRRIFQQLVSALTFCHAQGVY 426 LH ++R++ VMEY+ GG L HI GLK + +++ AL + H GV Sbjct: 836 NLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAA--EVLLALKYFHENGVI 893 Query: 427 HRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEV 579 +RD+K DN+++ G++KVAD+GL + A T CGTP ++ PE+ Sbjct: 894 YRDLKLDNIMLTLDGHIKVADYGLC--KENMWYGATTSTFCGTPEFMAPEI 942
>SGK2_MOUSE (Q9QZS5) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 367 Score = 106 bits (265), Expect = 4e-23 Identities = 56/179 (31%), Positives = 97/179 (54%), Gaps = 1/179 (0%) Frame = +1 Query: 55 PARYEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVM-RRL 231 P ++ +K++G+GN+ KV LA+ A+KV+ K+ ++K I E V+ + + Sbjct: 32 PTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNV 91 Query: 232 RHPNIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCH 411 RHP +V L +++ V++YV GG L+ H+ E R ++ SA+ + H Sbjct: 92 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLH 151 Query: 412 AQGVYHRDIKPDNLLVDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 + + +RD+KP+N+L+D G++ + DFGL + E T CGTP Y+ PEV + Sbjct: 152 SLNIIYRDLKPENILLDCQGHVVLTDFGLC--KECVEPEETTSTFCGTPEYLAPEVLRK 208
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 106 bits (265), Expect = 4e-23 Identities = 64/179 (35%), Positives = 90/179 (50%), Gaps = 4/179 (2%) Frame = +1 Query: 64 YEQVKLLGEGNFAKVYLARHMDTKEEVAIKVMDKEKLIKLGAVQQIKREIAVMRRLR-HP 240 Y K LG G F YL + + + A K + K KL+ + I+REI +M+ L P Sbjct: 65 YSFGKELGRGQFGVTYLCTEIASGRQYACKSISKRKLVSKADREDIRREIQIMQHLSGQP 124 Query: 241 NIVQLHKVMACKSRIFVVMEYVRGGPLYRHIPANGGLKEDETRRIFQQLVSALTFCHAQG 420 NIV+ KS + VVME GG L+ I A G E I + +V+ + CH G Sbjct: 125 NIVEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGHYTERAAATICRAVVNVVNICHFMG 184 Query: 421 VYHRDIKPDNLL---VDEHGNLKVADFGLSAHADTARREALLHTVCGTPLYVPPEVFAR 588 V HRD+KP+N L ++E+ LK DFGLS + + + + G+ YV PEV R Sbjct: 185 VMHRDLKPENFLLATMEENAMLKATDFGLSVFIEEGK---MYRDIVGSAYYVAPEVLRR 240 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 61,168,496 Number of Sequences: 219361 Number of extensions: 1098732 Number of successful extensions: 9170 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6492 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6861 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 5158951200 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
