ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal28n14 |
|---|---|
| Clone Library Name | barley_pub |
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 69.3 bits (168), Expect = 8e-12 Identities = 49/129 (37%), Positives = 72/129 (55%), Gaps = 12/129 (9%) Frame = +3 Query: 243 QHKSSGI-------ESTPA----EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR 389 QH S+G+ ST A ++ +L G+ +K +++ +KELGSG +G V GKW+ Sbjct: 378 QHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWK 437 Query: 390 G-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLA 566 G DVA+K IK +G SE E F++EAQ + L HP +V FYGV + + Sbjct: 438 GQYDVAVKMIK----EGSMSEDE-----FFQEAQTMMKLSHPKLVKFYGVC--SKEYPIY 486 Query: 567 TVTEFMVNG 593 VTE++ NG Sbjct: 487 IVTEYISNG 495
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 66.6 bits (161), Expect = 5e-11 Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%) Frame = +3 Query: 243 QHKSSGI-------ESTPAE----AEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR 389 QH S+G+ ST A + AL G+ +K +++ +KELG+G +G V G+W+ Sbjct: 354 QHNSAGMITRLRHPVSTKANKVPVSVALGSGIWELKREEITLLKELGNGQFGVVQLGQWK 413 Query: 390 G-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLA 566 G DVA+K IK +G SE E F++EAQ + L HP +V FYGV + Sbjct: 414 GQYDVAVKMIK----EGAMSEDE-----FFQEAQTMMKLSHPKLVKFYGVC--SKKYPIY 462 Query: 567 TVTEFMVNG 593 VTE++ NG Sbjct: 463 IVTEYITNG 471
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 62.8 bits (151), Expect = 7e-10 Identities = 48/130 (36%), Positives = 67/130 (51%), Gaps = 13/130 (10%) Frame = +3 Query: 243 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 386 QH S+G+ ++ P+ A L G I DL +KELG+G +G V +GKW Sbjct: 362 QHNSAGLISRLKYPVSQQNKNAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 420 Query: 387 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSL 563 RG DVAIK IK +G SE E F +EA+++ +L H +V YGV + Sbjct: 421 RGQYDVAIKMIK----EGSMSEDE-----FIEEAKVMMNLSHEKLVQLYGVCT--KQRPI 469 Query: 564 ATVTEFMVNG 593 +TE+M NG Sbjct: 470 FIITEYMANG 479
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 61.6 bits (148), Expect = 2e-09 Identities = 47/130 (36%), Positives = 67/130 (51%), Gaps = 13/130 (10%) Frame = +3 Query: 243 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 386 QH S+G+ ++ P+ A L G I DL +KELG+G +G V +GKW Sbjct: 362 QHNSAGLISRLKYPVSKQNKNAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 420 Query: 387 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSL 563 RG DVAIK I+ +G SE E F +EA+++ +L H +V YGV + Sbjct: 421 RGQYDVAIKMIR----EGSMSEDE-----FIEEAKVMMNLSHEKLVQLYGVCT--KQRPI 469 Query: 564 ATVTEFMVNG 593 +TE+M NG Sbjct: 470 FIITEYMANG 479
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/117 (37%), Positives = 61/117 (52%), Gaps = 1/117 (0%) Frame = +3 Query: 249 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC-DVAIKRIKAS 425 KSS + LS I +L ++ELGSG +G V GKWRG D A+K +K Sbjct: 500 KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK-- 557 Query: 426 CFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +G SE DF +EA++++ L HPN+V YGV + VTE+M +GS Sbjct: 558 --EGTMSED-----DFIEEAKVMTKLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGS 605
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 61.2 bits (147), Expect = 2e-09 Identities = 42/144 (29%), Positives = 66/144 (45%) Frame = +3 Query: 165 DNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKE 344 D+ G D N D + D+ D K ++ + I D++ K+ Sbjct: 1316 DDTDSGTADDSNYDSGKIIDIDYMADIDKEDSFLTSANMCRWI------INYDEISIGKQ 1369 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +G G+YG VF+GKW+G DVA+K+ + E + +F E LS L H N+V+ Sbjct: 1370 IGLGSYGIVFNGKWKGVDVAVKKFV------KQKLSETQLLEFRAEMAFLSELKHSNIVT 1423 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G P ++ VTE+M G+ Sbjct: 1424 FIGACIKKP--NICIVTEYMRMGN 1445 Score = 55.5 bits (132), Expect = 1e-07 Identities = 40/108 (37%), Positives = 56/108 (51%), Gaps = 6/108 (5%) Frame = +3 Query: 291 LSKGLQTIKND------DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSER 452 L K T ND +LE + LG+G YG V+ W+G +VA+K I +S + ER Sbjct: 768 LLKHRNTTNNDWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLI-SSKHVSKDMER 826 Query: 453 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F++E +I++SL HPNVV F P ++ V EFM GS Sbjct: 827 -----SFFEEVKIMTSLRHPNVVLFMAASTKSP--NMCIVMEFMSLGS 867
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 61.2 bits (147), Expect = 2e-09 Identities = 43/129 (33%), Positives = 68/129 (52%), Gaps = 14/129 (10%) Frame = +3 Query: 252 SSGIESTPAEAEALSKGLQTIKN-------DDLE------EIKE-LGSGTYGSVFHGKWR 389 S+ IE+ P A +S+ + N DD++ IKE +G+G++G+V +W Sbjct: 512 SNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH 571 Query: 390 GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 569 G DVA+K + F +ER + +F +E I+ L HPN+V F G V P +L+ Sbjct: 572 GSDVAVKILMEQDFH---AER---VNEFLREVAIMKRLRHPNIVLFMGAVTQPP--NLSI 623 Query: 570 VTEFMVNGS 596 VTE++ GS Sbjct: 624 VTEYLSRGS 632
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 60.1 bits (144), Expect = 5e-09 Identities = 47/130 (36%), Positives = 66/130 (50%), Gaps = 13/130 (10%) Frame = +3 Query: 243 QHKSSGI------------ESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKW 386 QH S+G+ +S P+ A L G I DL +KELG+G +G V +GKW Sbjct: 361 QHNSAGLISRLKYPVSRHQKSAPSTA-GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 419 Query: 387 RG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSL 563 RG +VAIK I+ +G SE E F EA+++ +L H +V YGV + Sbjct: 420 RGQYNVAIKMIR----EGSMSEDE-----FIDEAKVMMNLSHEKLVQLYGVCT--KQRPI 468 Query: 564 ATVTEFMVNG 593 +TE+M NG Sbjct: 469 FIITEYMANG 478
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 58.2 bits (139), Expect = 2e-08 Identities = 37/92 (40%), Positives = 46/92 (50%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 500 ++LE + +G G +G V G WR DVAIK I F + S + F E ILS Sbjct: 1287 NELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSS-----LVMFQNEVGILSK 1341 Query: 501 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L HPNVV F G G + VTE+M GS Sbjct: 1342 LRHPNVVQFLGACTAGGEDHHCIVTEWMGGGS 1373
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 56.2 bits (134), Expect = 7e-08 Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 1/108 (0%) Frame = +3 Query: 276 AEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSER 452 A+ +K + I + L+ IK LG+G +G V+ G W G VA+K +K Sbjct: 253 ADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPE---- 308 Query: 453 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTE+M GS Sbjct: 309 -----SFLEEAQIMKKLRHDKLVQLYAVVSEEP---IYIVTEYMSKGS 348
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 55.8 bits (133), Expect = 9e-08 Identities = 39/126 (30%), Positives = 59/126 (46%), Gaps = 1/126 (0%) Frame = +3 Query: 222 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 398 D G C + K +E T A + S+ + DL+ ++ +G G +G V G +RG Sbjct: 159 DADGLCSRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNK 218 Query: 399 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSG-LYIVTE 267 Query: 579 FMVNGS 596 +M GS Sbjct: 268 YMAKGS 273
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 55.5 bits (132), Expect = 1e-07 Identities = 36/105 (34%), Positives = 53/105 (50%), Gaps = 2/105 (1%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 +L IK DDL+ + G G++GSV+ KW D VA+K++ Sbjct: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------- 47 Query: 462 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 KEA+ILS L H N++ FYGV+ + P+ + VTE+ GS Sbjct: 48 -LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGI--VTEYASLGS 89
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 55.5 bits (132), Expect = 1e-07 Identities = 36/105 (34%), Positives = 53/105 (50%), Gaps = 2/105 (1%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 +L IK DDL+ + G G++GSV+ KW D VA+K++ Sbjct: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------- 47 Query: 462 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 KEA+ILS L H N++ FYGV+ + P+ + VTE+ GS Sbjct: 48 -LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGI--VTEYASLGS 89
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 55.1 bits (131), Expect = 2e-07 Identities = 32/96 (33%), Positives = 52/96 (54%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I +++E + E+G G +GSV KW R +VA K +++S +ERE+ + EA+ Sbjct: 215 INRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSS-----KAEREKFVL----EAK 265 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 I+ L H +V GV + D + + E+M NGS Sbjct: 266 IMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGS 301
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 55.1 bits (131), Expect = 2e-07 Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 1/102 (0%) Frame = +3 Query: 294 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIAD 470 +K + I + L+ IK LG+G +G V+ G W G VAIK +K Sbjct: 259 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---------S 309 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTE+M GS Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEYMSKGS 348
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 54.7 bits (130), Expect = 2e-07 Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 1/108 (0%) Frame = +3 Query: 276 AEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSER 452 A+ +K + I + L+ +++LG+G +G V+ G W G VA+K +K Sbjct: 252 ADLSVKTKDVWEIPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPEA--- 308 Query: 453 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 309 ------FLEEAQIMKRLRHDKLVQLYAVVSEEP---IYIVTEFMSQGS 347
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 54.7 bits (130), Expect = 2e-07 Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 1/102 (0%) Frame = +3 Query: 294 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIAD 470 +K + I + L+ IK LG+G +G V+ G W G VAIK +K Sbjct: 259 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---------S 309 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTE+M GS Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEYMNKGS 348
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 53.5 bits (127), Expect = 4e-07 Identities = 32/91 (35%), Positives = 50/91 (54%) Frame = +3 Query: 324 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 ++E + +GSG++G V+ G+ R VAIKR +A+ + + + F +E IL L Sbjct: 461 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQL 515 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +HP VV F G D P A VT+++ GS Sbjct: 516 NHPCVVQFVGACLDDP-SQFAIVTQYISGGS 545
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 53.5 bits (127), Expect = 4e-07 Identities = 36/107 (33%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + LSK I D L +LG G +G V+ G W G VAIK +K Sbjct: 249 QTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 304 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 305 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 343
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 53.5 bits (127), Expect = 4e-07 Identities = 39/96 (40%), Positives = 52/96 (54%), Gaps = 2/96 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I +L +KE+GSG +G V G+WR VAIK I +G SE DF +EA+ Sbjct: 266 IDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAIN----EGSMSEE-----DFIEEAK 316 Query: 489 ILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNG 593 ++ L H +V YGV ++ P L VTEFM NG Sbjct: 317 VMMKLSHSRLVQLYGVCIQQKP---LYIVTEFMENG 349
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 53.5 bits (127), Expect = 4e-07 Identities = 40/96 (41%), Positives = 52/96 (54%), Gaps = 2/96 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I +L IKE+GSG +G V G+WR VAIK I +G SE DF +EA+ Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN----EGSMSEE-----DFIEEAK 316 Query: 489 ILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNG 593 ++ L H +V YGV ++ P L VTEFM NG Sbjct: 317 VMMKLSHSKLVQLYGVCIQRKP---LYIVTEFMENG 349
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 53.5 bits (127), Expect = 4e-07 Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 1/102 (0%) Frame = +3 Query: 294 SKGLQTIKNDDLEEIKELGSGTYGSVFHGKW-RGCDVAIKRIKASCFDGRPSERERLIAD 470 +K + I D + I++LG+G +G V+ G W VA+K +KA A Sbjct: 84 TKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQP---------AA 134 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F EAQI+ L HP ++ Y V G + +TE M GS Sbjct: 135 FLAEAQIMKKLRHPKLIQLYAVCTQGE--PVYIITELMSKGS 174
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 53.5 bits (127), Expect = 4e-07 Identities = 32/91 (35%), Positives = 50/91 (54%) Frame = +3 Query: 324 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 ++E + +GSG++G V+ G+ R VAIKR +A+ + + + F +E IL L Sbjct: 460 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQL 514 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +HP VV F G D P A VT+++ GS Sbjct: 515 NHPCVVQFVGACLDDP-SQFAIVTQYISGGS 544
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 52.8 bits (125), Expect = 8e-07 Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 1/113 (0%) Frame = +3 Query: 258 GIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFD 434 G + P A L G I +L ++E+GSG +G V G W D VAIK I+ + Sbjct: 341 GRQKAPVTA-GLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIR----E 395 Query: 435 GRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 G SE DF +EA+++ L HP +V YGV + + V EFM +G Sbjct: 396 GAMSEE-----DFIEEAEVMMKLSHPKLVQLYGVCLE--QAPICLVFEFMEHG 441
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 52.8 bits (125), Expect = 8e-07 Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 1/126 (0%) Frame = +3 Query: 222 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 398 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 399 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 579 FMVNGS 596 +M GS Sbjct: 268 YMAKGS 273
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 52.8 bits (125), Expect = 8e-07 Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 1/126 (0%) Frame = +3 Query: 222 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 398 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 399 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 579 FMVNGS 596 +M GS Sbjct: 268 YMAKGS 273
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 52.8 bits (125), Expect = 8e-07 Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 1/126 (0%) Frame = +3 Query: 222 DVHGSCDQH-KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 398 D G C + K +E T A + + + +L+ ++ +G G +G V G +RG Sbjct: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK 218 Query: 399 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 VA+K IK + F EA +++ L H N+V GV+ + G L VTE Sbjct: 219 VAVKCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTE 267 Query: 579 FMVNGS 596 +M GS Sbjct: 268 YMAKGS 273
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 52.8 bits (125), Expect = 8e-07 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 1/111 (0%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRP 443 S + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 SVKPQTQGLAKDAWEIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTM---- 305 Query: 444 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + F +EAQI+ L H +V Y VV + P + VTE+M+ GS Sbjct: 306 -----MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEYMIKGS 348
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 52.8 bits (125), Expect = 8e-07 Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 1/87 (1%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 515 ++LG G +G V+ G W G VA+K +K + + DF +EAQ++ +HHPN Sbjct: 70 RKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTME---------VKDFVQEAQVMKKIHHPN 120 Query: 516 VVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++ Y V G + VTE M GS Sbjct: 121 LLQLYAVCTIGE--PIYIVTELMKYGS 145
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 52.4 bits (124), Expect = 1e-06 Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 309 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 310 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMTKGS 352
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 52.4 bits (124), Expect = 1e-06 Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 251 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM-------- 302 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 303 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMTKGS 345
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 52.4 bits (124), Expect = 1e-06 Identities = 33/103 (32%), Positives = 54/103 (52%), Gaps = 7/103 (6%) Frame = +3 Query: 306 QTIKNDDLEEIKELGSGTYGSVFHG-------KWRGCDVAIKRIKASCFDGRPSERERLI 464 +T++ + ++ +G G +G VF G K VA+K +K SC D L Sbjct: 497 KTVRLQTILLMRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDS-------LK 549 Query: 465 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L+++ H N+V+FYGV + + + EFM NG Sbjct: 550 RDFEREAEMLATIEHANIVTFYGVCTESDQWMM--IFEFMENG 590
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 52.4 bits (124), Expect = 1e-06 Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I + ++ +K LGSG +G V+ G W VA+K +K D DF +EAQ Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN---------DFLREAQ 279 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 I+ +L HP ++ Y V + + +TE M +GS Sbjct: 280 IMKNLRHPKLIQLYAVCT--LEDPIYIITELMRHGS 313
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 52.0 bits (123), Expect = 1e-06 Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 1/102 (0%) Frame = +3 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 467 L G I+ +L ++E+GSG +G V G W D VAIK I+ +G SE Sbjct: 356 LRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQ----EGAMSEE----- 406 Query: 468 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA+++ L HP +V YGV + + V EFM +G Sbjct: 407 DFIEEAEVMMKLSHPKLVQLYGVCLE--QAPICLVFEFMEHG 446
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 52.0 bits (123), Expect = 1e-06 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 2/87 (2%) Frame = +3 Query: 342 ELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 515 +LG G YG V+ G W+ C +A+K +K D P + +F EA I+ LHH N Sbjct: 316 KLGGGQYGDVYEGYWKRHDCTIAVKALKE---DAMP------LHEFLAEAAIMKDLHHKN 366 Query: 516 VVSFYGVVRDGPDGSLATVTEFMVNGS 596 +V GV + +TEFM NG+ Sbjct: 367 LVRLLGVCTH--EAPFYIITEFMCNGN 391
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 51.6 bits (122), Expect = 2e-06 Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 260 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 311 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 312 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGS 354
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 51.6 bits (122), Expect = 2e-06 Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM-------- 309 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 310 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGS 352
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 51.6 bits (122), Expect = 2e-06 Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 3/119 (2%) Frame = +3 Query: 249 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKE---LGSGTYGSVFHGKWRGCDVAIKRIK 419 K + A+ L GL + + L EI+ +GSG++G V+ G+ R VAIKR + Sbjct: 433 KIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYR 492 Query: 420 ASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 A+ + + + F +E IL L+HP V+ F G + P A VT+++ GS Sbjct: 493 ANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGS 545
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 51.6 bits (122), Expect = 2e-06 Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 256 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM-------- 307 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 308 -MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGS 350
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 51.6 bits (122), Expect = 2e-06 Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 3/119 (2%) Frame = +3 Query: 249 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKE---LGSGTYGSVFHGKWRGCDVAIKRIK 419 K + A+ L GL + + L EI+ +GSG++G V+ G+ R VAIKR + Sbjct: 535 KIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYR 594 Query: 420 ASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 A+ + + + F +E IL L+HP V+ F G + P A VT+++ GS Sbjct: 595 ANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGS 647
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 51.2 bits (121), Expect = 2e-06 Identities = 37/95 (38%), Positives = 49/95 (51%), Gaps = 1/95 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I +L ++ELGSG +G V GKWR VAIK I+ +G E DF +EA+ Sbjct: 364 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR----EGAMCEE-----DFIEEAK 414 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 ++ L HP +V YGV + VTEFM G Sbjct: 415 VMMKLTHPKLVQLYGVCTQ--QKPIYIVTEFMERG 447
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 51.2 bits (121), Expect = 2e-06 Identities = 37/95 (38%), Positives = 49/95 (51%), Gaps = 1/95 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I +L ++ELGSG +G V GKWR VAIK I+ +G E DF +EA+ Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR----EGAMCEE-----DFIEEAK 415 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 ++ L HP +V YGV + VTEFM G Sbjct: 416 VMMKLTHPKLVQLYGVCTQ--QKPIYIVTEFMERG 448
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 51.2 bits (121), Expect = 2e-06 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 623
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 51.2 bits (121), Expect = 2e-06 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 623
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 51.2 bits (121), Expect = 2e-06 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 623
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 51.2 bits (121), Expect = 2e-06 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 623
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 51.2 bits (121), Expect = 2e-06 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKDKMLVAVKALK 575 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 623
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 253 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 308 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 309 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 347
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + LS+ I D L +LG G +G V+ G W G VAIK +K Sbjct: 249 QTQGLSRDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 304 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE++ GS Sbjct: 305 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYISKGS 343
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 344
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 344
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 344
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 50.8 bits (120), Expect = 3e-06 Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P+ + L+A Sbjct: 532 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTNDKMLVAVKALK 577 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 578 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 625
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 50.8 bits (120), Expect = 3e-06 Identities = 36/111 (32%), Positives = 49/111 (44%), Gaps = 1/111 (0%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRP 443 S + L+K + D L K+LG G + V+ G W G VAIK +K Sbjct: 247 SCTPQTSGLAKDAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPE- 305 Query: 444 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTE+M GS Sbjct: 306 --------SFLEEAQIMKKLKHDKLVQLYAVVSEEP---IYIVTEYMSKGS 345
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 344
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGS 344
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 50.8 bits (120), Expect = 3e-06 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 13/110 (11%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIA----- 467 +Q IK D+ +ELG G +G VF A C++ P++ + L+A Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVF--------------LAECYNLSPTKVKMLVAVKALK 575 Query: 468 --------DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV DG L V E+M +G Sbjct: 576 DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG--DPLIMVFEYMKHG 623
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 253 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 308 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 309 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMNKGS 347
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/100 (34%), Positives = 49/100 (49%) Frame = +3 Query: 234 SCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKR 413 S SS S EA + + I ++E + +G G +G V KWR DVAIK+ Sbjct: 5 SAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQ 64 Query: 414 IKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYG 533 I++ SER+ I E + LS ++HPN+V YG Sbjct: 65 IESE------SERKAFIV----ELRQLSRVNHPNIVKLYG 94
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 258 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 313 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 314 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMNKGS 352
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 50.4 bits (119), Expect = 4e-06 Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + ++K I + L LG G +G V+ G W G VAIK +K Sbjct: 261 QTQGIAKDAWEIPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEA---- 316 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 317 -----FLEEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMGKGS 355
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTE+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVRLYAVVSEEP---IYIVTEYMSKGS 344
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 50.4 bits (119), Expect = 4e-06 Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 1/103 (0%) Frame = +3 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 467 L+K I + + LG+G +G V+ G W G VA+K +K + Sbjct: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKA-------- 302 Query: 468 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + VTEFM +GS Sbjct: 303 -FLEEAQVMKLLRHDKLVQLYAVVSEEP---IYIVTEFMCHGS 341
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 50.1 bits (118), Expect = 5e-06 Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 1/103 (0%) Frame = +3 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERERLIA 467 L+K I + + LG+G +G V+ G W G VA+K +K + S Sbjct: 274 LAKDAWEISRSSITLQRRLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKAS------- 326 Query: 468 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +EAQI+ L H +V Y VV P+ + VTEFM +GS Sbjct: 327 --LEEAQIMKLLRHDKLVQLYAVV---PEEPIYIVTEFMCHGS 364
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 49.7 bits (117), Expect = 6e-06 Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 2/97 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 287 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++ + HPN+V GV P +TEFM G+ Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGN 322
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 49.7 bits (117), Expect = 6e-06 Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 2/97 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 123 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 173 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++ + HPN+V GV P +TEFM G+ Sbjct: 174 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGN 208
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 49.7 bits (117), Expect = 6e-06 Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 2/97 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 186 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 236 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++ + HPN+V GV P +TEFM G+ Sbjct: 237 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGN 271
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 49.7 bits (117), Expect = 6e-06 Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 2/97 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 287 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++ + HPN+V GV P +TEFM G+ Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGN 322
>ACK1_HUMAN (Q07912) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine| kinase non-receptor protein 2) Length = 1036 Score = 49.7 bits (117), Expect = 6e-06 Identities = 35/126 (27%), Positives = 50/126 (39%) Frame = +3 Query: 219 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 398 P H K+S PA L I DL +++LG G++G V G+W Sbjct: 90 PPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPS 149 Query: 399 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 + C + + DF +E + SL H N++ YGVV P + VTE Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP---MKMVTE 206 Query: 579 FMVNGS 596 GS Sbjct: 207 LAPLGS 212
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 49.3 bits (116), Expect = 8e-06 Identities = 36/91 (39%), Positives = 48/91 (52%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +GSG G V +G+ R VAIK +KA +ER+R DF +EA I+ Sbjct: 6 KIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGY-----TERQR--QDFLREAAIMGQF 58 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV G + VTE+M NGS Sbjct: 59 DHPNIIRLEGVVTRGRLAMI--VTEYMENGS 87
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 49.3 bits (116), Expect = 8e-06 Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I L+ +++LGSG +G V+ G W VAIK +K+ D + DF EAQ Sbjct: 243 IDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPK---------DFLAEAQ 293 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 I+ L H ++ Y V + + +TE M +GS Sbjct: 294 IMKKLRHTKLIQLYAVCT--VEEPIYIITELMKHGS 327
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 49.3 bits (116), Expect = 8e-06 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 L++I++LG G +G V G G VA+K +K P RE ++ W+E Sbjct: 875 LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLK-------PENREEQSSNLWREIH 927 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 IL L+H N+V + G+ + S+ + EF+ GS Sbjct: 928 ILRELYHENIVKYKGIWHEEGGRSIKLIMEFLPAGS 963
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/92 (30%), Positives = 46/92 (50%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 500 +D++ I+++G G + V+ G W+G VAIK++K + E+ F +E Q L Sbjct: 106 NDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLKII------GDEEQFKERFIREVQNLKK 159 Query: 501 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +H N+V F G +TE+M GS Sbjct: 160 GNHQNIVMFIGACYK----PACIITEYMAGGS 187
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 48.9 bits (115), Expect = 1e-05 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR-GCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I +++ +++LG G +G VF+GKWR DVA+K ++ E A F +EA Sbjct: 279 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR---------EGTMSTAAFLQEAA 329 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 I+ H +V+ Y V + + V E+M GS Sbjct: 330 IMKKFRHNRLVALYAVC--SQEEPIYIVQEYMSKGS 363
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 48.9 bits (115), Expect = 1e-05 Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 L++I++LG G +G V G G VA+K +K P RE + W+E Sbjct: 872 LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLK-------PENREEQSNNLWREIH 924 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 IL L+H N+V + G+ + S+ + EF+ GS Sbjct: 925 ILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGS 960
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 48.9 bits (115), Expect = 1e-05 Identities = 36/91 (39%), Positives = 47/91 (51%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +GSG G V +G+ R VAIK +KA +ER+R DF EA I+ Sbjct: 639 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-----TERQR--RDFLSEASIMGQF 691 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV G + VTE+M NGS Sbjct: 692 DHPNIIRLEGVVTRGRLAMI--VTEYMENGS 720
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + V E+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVIEYMSKGS 344
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 48.9 bits (115), Expect = 1e-05 Identities = 34/94 (36%), Positives = 50/94 (53%) Frame = +3 Query: 252 SSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCF 431 SS E A ++ L+ K ++EE+ +G G +G V KWR DVAIK+I++ Sbjct: 13 SSAGEMIEAPSQVLNFEEIDYKEIEVEEV--VGRGAFGVVCKAKWRAKDVAIKQIESE-- 68 Query: 432 DGRPSERERLIADFWKEAQILSSLHHPNVVSFYG 533 SER+ I E + LS ++HPN+V YG Sbjct: 69 ----SERKAFIV----ELRQLSRVNHPNIVKLYG 94
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 48.5 bits (114), Expect = 1e-05 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + V E+M GS Sbjct: 306 -----FLQEAQVMKKLRHKKLVQLYAVVSEEP---IYIVIEYMSKGS 344
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/111 (30%), Positives = 51/111 (45%), Gaps = 1/111 (0%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR-GCDVAIKRIKASCFDGRP 443 +T + L+K I + + + LG+G +G V+ G W VA+K +K + Sbjct: 231 TTKPQTLGLAKDAWEIDRNSIALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKA 290 Query: 444 SERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQI+ L H +V Y VV + P + VTEFM GS Sbjct: 291 ---------FLEEAQIMKLLRHDKLVQLYAVVSEEP---IYIVTEFMCYGS 329
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 622 IEEV--IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY-----SEKQR--RDFLSEASI 672 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + +TEFM NG+ Sbjct: 673 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGA 705
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 48.5 bits (114), Expect = 1e-05 Identities = 38/123 (30%), Positives = 52/123 (42%), Gaps = 1/123 (0%) Frame = +3 Query: 231 GSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAI 407 G C +TP + L+K + D L ++LG G + V+ G W G VAI Sbjct: 236 GLCFNLTVIATNNTP-QTVGLAKDAWEVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAI 294 Query: 408 KRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMV 587 K +K F +EAQI+ L H +V Y VV P + VTE+M Sbjct: 295 KTLKPGTMSPE---------SFLEEAQIMKKLKHDKLVQLYAVVSRRP---IYIVTEYMS 342 Query: 588 NGS 596 GS Sbjct: 343 KGS 345
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 2/93 (2%) Frame = +3 Query: 318 NDDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 + +++++LG+GTY +V+ G K G VA+K +K +G PS R E + Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-------EISL 56 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVN 590 + L H N+V Y V+ + L V EFM N Sbjct: 57 MKELKHENIVRLYDVIH--TENKLTLVFEFMDN 87
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 539 IEEV--IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY-----SEKQR--RDFLSEASI 589 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + +TEFM NG+ Sbjct: 590 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGA 622
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 2/87 (2%) Frame = +3 Query: 342 ELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 515 +LG G YG V+ W+ G VA+K +K E + DF +EA I+ + HPN Sbjct: 376 KLGGGQYGEVYEAVWKRYGNTVAVKTLK---------EDTMALKDFLEEAAIMKEMKHPN 426 Query: 516 VVSFYGVVRDGPDGSLATVTEFMVNGS 596 +V GV P +TEFM +G+ Sbjct: 427 LVQLIGVCTREP--PFYIITEFMSHGN 451
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 48.5 bits (114), Expect = 1e-05 Identities = 36/91 (39%), Positives = 47/91 (51%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +GSG G V +G+ R VAIK +KA +ER+R DF EA I+ Sbjct: 638 KIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGY-----TERQR--QDFLSEAAIMGQF 690 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV G + VTE+M NGS Sbjct: 691 DHPNIIRLEGVVTRGRLAMI--VTEYMENGS 719
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 48.1 bits (113), Expect = 2e-05 Identities = 32/95 (33%), Positives = 50/95 (52%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII----RELQV 117 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYGV DG ++ E M GS Sbjct: 118 LHECNSPYIVGFYGVFYS--DGEISICMEHMDGGS 150
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 LHHPN+V V+ D L + EF+ Sbjct: 56 KELHHPNIVCLQDVLMQ--DARLYLIFEFL 83
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I+ ++ ++ LG+G +G V+ G W G VA+K +K I +F +EA Sbjct: 235 IEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------IEEFLEEAS 285 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 I+ L HP ++ Y V + + VTE M +GS Sbjct: 286 IMKQLRHPKLIQLYAVCT--KEEPIYIVTELMKHGS 319
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 47.8 bits (112), Expect = 2e-05 Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 2/89 (2%) Frame = +3 Query: 330 EEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 ++++ LG+GTY +V+ G K G VA+K +K +G PS R E ++ L Sbjct: 10 KQLERLGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIR-------EISLMKEL 62 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVN 590 H N+V Y V+ + L V EFM N Sbjct: 63 KHENIVRLYDVIH--TENKLTLVFEFMDN 89
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 47.8 bits (112), Expect = 2e-05 Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVF------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 L+ I++LG G +G V G G VA+K +K P IAD KE + Sbjct: 874 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-------PESGGNHIADLKKEIE 926 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 IL +L+H N+V + G+ + + + EF+ +GS Sbjct: 927 ILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGS 962
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 47.8 bits (112), Expect = 2e-05 Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 6/124 (4%) Frame = +3 Query: 228 HGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWR--GCDV 401 +G + + SG++ +P + + L N D E+I+E+G G +G VF K R G Sbjct: 209 NGLGENKRKSGVKVSPDDVQRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRY 268 Query: 402 AIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFY----GVVRDGPDGSLAT 569 AIKR+K ++ +E E Q L+ L+H N+V ++ GV D P+ S++ Sbjct: 269 AIKRVK---YNTEKAEH---------EVQALAELNHVNIVQYHSCWEGVDYD-PEHSMSD 315 Query: 570 VTEF 581 + + Sbjct: 316 TSRY 319
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 7/104 (6%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 461 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 526 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 579 Query: 462 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV +G L V E+M +G Sbjct: 580 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHG 619
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 47.4 bits (111), Expect = 3e-05 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 2/95 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 + + +++++LG+GTY +V+ G K G VA+K +K +G PS R E Sbjct: 1 MSSSQFKQLEKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIR-------EI 53 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVN 590 ++ L H N+V Y V+ + L V E+M N Sbjct: 54 SLMKELKHDNIVRLYDVIH--TENKLTLVFEYMDN 86
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + +TEFM NG+ Sbjct: 672 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGA 704
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + +TEFM NG+ Sbjct: 672 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGA 704
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V+ G+ R VAIK +KA SE++R DF EA I Sbjct: 621 IEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-----SEKQR--RDFLSEASI 671 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + +TEFM NG+ Sbjct: 672 MGQFDHPNIIRLEGVVT--KSRPVMIITEFMENGA 704
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 47.4 bits (111), Expect = 3e-05 Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 14/135 (10%) Frame = +3 Query: 171 DKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKN---------- 320 D G+ D G P S + S + S E ++L+ + +KN Sbjct: 242 DAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYYW 301 Query: 321 ----DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 +++ +K +G+G++G+VF G+W G DVA+K +K + +P+ + F E Q Sbjct: 302 EVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QPTAEQ--AQAFKNEMQ 354 Query: 489 ILSSLHHPNVVSFYG 533 +L H N++ F G Sbjct: 355 VLRKTRHVNILLFMG 369
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 47.4 bits (111), Expect = 3e-05 Identities = 41/162 (25%), Positives = 72/162 (44%) Frame = +3 Query: 111 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 290 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 470 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +E Q+L + P +V FYG DG ++ E M GS Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 149
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 47.4 bits (111), Expect = 3e-05 Identities = 41/162 (25%), Positives = 72/162 (44%) Frame = +3 Query: 111 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 290 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 470 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +E Q+L + P +V FYG DG ++ E M GS Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 149
>MP2K1_PANTR (Q9XT09) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 47.4 bits (111), Expect = 3e-05 Identities = 41/162 (25%), Positives = 72/162 (44%) Frame = +3 Query: 111 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 290 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 470 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +E Q+L + P +V FYG DG ++ E M GS Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 149
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 47.4 bits (111), Expect = 3e-05 Identities = 41/162 (25%), Positives = 72/162 (44%) Frame = +3 Query: 111 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 290 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 470 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +E Q+L + P +V FYG DG ++ E M GS Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 149
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 47.4 bits (111), Expect = 3e-05 Identities = 41/162 (25%), Positives = 72/162 (44%) Frame = +3 Query: 111 EKPVEVQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 290 +KP +Q + P S V + N + Q D+ + +E+ + + Sbjct: 3 KKPTPIQLNPAPDGSAV----NGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 58 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 470 + + +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I Sbjct: 59 VGE----LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQII-- 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +E Q+L + P +V FYG DG ++ E M GS Sbjct: 112 --RELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 149
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 A+ K +K++DL +++G G +G VF G+ R + VA+K SC + P + L Sbjct: 546 AVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVK----SCRETLPPD---L 598 Query: 462 IADFWKEAQILSSLHHPNVVSFYGV 536 A F +EA+IL +HPN+V GV Sbjct: 599 KAKFLQEARILKQYNHPNIVRLIGV 623
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ R G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+VS V+ D L + EF+ Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL 83
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ R G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+VS V+ D L + EF+ Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL 83
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 7/104 (6%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 461 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 529 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 582 Query: 462 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV +G L V E+M +G Sbjct: 583 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHG 622
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 7/104 (6%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 461 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 529 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 582 Query: 462 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV +G L V E+M +G Sbjct: 583 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHG 622
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 7/104 (6%) Frame = +3 Query: 303 LQTIKNDDLEEIKELGSGTYGSVFHGK-WRGCD------VAIKRIKASCFDGRPSERERL 461 +Q IK ++ +ELG G +G VF + + C VA+K +K + + R Sbjct: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK------ 583 Query: 462 IADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 DF +EA++L++L H ++V FYGV +G L V E+M +G Sbjct: 584 --DFHREAELLTNLQHEHIVKFYGVCVEG--DPLIMVFEYMKHG 623
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 47.0 bits (110), Expect = 4e-05 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 I+ ++ ++ LG+G +G V+ G W G VA+K +K + +F +EA Sbjct: 235 IEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------VEEFLQEAS 285 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 I+ L HP ++ Y V + + VTE M GS Sbjct: 286 IMKRLRHPKLIQLYAVCT--KEEPIYIVTELMKYGS 319
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 47.0 bits (110), Expect = 4e-05 Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W G VAIK +K Sbjct: 247 QTQGLAKDAWEIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---- 302 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y +V + P + V E+M GS Sbjct: 303 -----FLQEAQVMKKLRHEKLVQLYAMVSEEP---IYIVIEYMSKGS 341
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 47.0 bits (110), Expect = 4e-05 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 L+ I++LG G +G V ++ G VA+K +K P IAD KE +I Sbjct: 864 LKRIRDLGEGHFGKVELCRYDPEDNTGEQVAVKSLK-------PESGGNHIADLKKEIEI 916 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L +L+H N+V + G+ + + + EF+ +GS Sbjct: 917 LRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGS 951
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 47.0 bits (110), Expect = 4e-05 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 2/111 (1%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKND--DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 440 +TP A LS+ L D + + LGSG +GSV+ + G VAIK++ R Sbjct: 39 ATPPRAPRLSRRLAWCFIDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLR 98 Query: 441 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 S+R +FW E I + LHH N++ P+GS + T M G Sbjct: 99 ASQR-----NFWAELNI-ARLHHDNIIRVVAASTRTPEGSNSLGTIIMEFG 143
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.0 bits (110), Expect = 4e-05 Identities = 31/90 (34%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+VS V+ D L + EF+ Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL 83
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.0 bits (110), Expect = 4e-05 Identities = 31/90 (34%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+VS V+ D L + EF+ Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL 83
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 46.6 bits (109), Expect = 5e-05 Identities = 32/104 (30%), Positives = 52/104 (50%), Gaps = 2/104 (1%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSER 452 E E +G +D +++++G GTYG V+ GK R + VA+K+I+ SE Sbjct: 6 EGEVAHEGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLE------SED 59 Query: 453 ERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 E + + +E +L L HPNVV V+ + L + EF+ Sbjct: 60 EGVPSTAVREISLLKELQHPNVVGLEAVIMQ--ENRLFLIFEFL 101
>ACK2_BOVIN (O02742) Activated CDC42 kinase 2 (EC 2.7.10.2) (ACK-2)| Length = 747 Score = 46.6 bits (109), Expect = 5e-05 Identities = 34/126 (26%), Positives = 49/126 (38%) Frame = +3 Query: 219 PDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD 398 P H K+S A +L I DL ++LG G++G V G+W Sbjct: 90 PPHHSQSTFRKTSPTPGGSAGEGSLQSLTCLIGEKDLHLFEKLGDGSFGVVRRGEWDAPS 149 Query: 399 VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 + C + + DF +E + SL H N++ YGVV P + VTE Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP---MKMVTE 206 Query: 579 FMVNGS 596 GS Sbjct: 207 LAPLGS 212
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 46.2 bits (108), Expect = 7e-05 Identities = 31/95 (32%), Positives = 48/95 (50%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E I ELG+G G V + R + + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKARHRPSGLIMAR-KLIHLEIKPAVRNQII----RELQV 121 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYG DG ++ E M GS Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 154
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 46.2 bits (108), Expect = 7e-05 Identities = 30/95 (31%), Positives = 49/95 (51%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E++ ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 62 LKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMAR-KLIHLEIKPAIRNQII----RELQV 116 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYG DG ++ E M GS Sbjct: 117 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 149
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 46.2 bits (108), Expect = 7e-05 Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 7/94 (7%) Frame = +3 Query: 333 EIKELGSGTYGSVFHGKWRG--CDVAIKRIKASCFD-GRPSERERLIADF----WKEAQI 491 ++++LGSG YG V K + + AIK IK S FD GR ++ + I F + E + Sbjct: 58 KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFHEEIYNEISL 117 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 L SL HPN++ + V D L VTEF G Sbjct: 118 LKSLDHPNIIKLFDVFEDKKYFYL--VTEFYEGG 149
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 46.2 bits (108), Expect = 7e-05 Identities = 31/95 (32%), Positives = 49/95 (51%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E+I ELG+G G VF + + + R K + +P+ R ++I +E Q+ Sbjct: 56 LKDDDFEKISELGAGNGGVVFKVSHKPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 110 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYG DG ++ E M GS Sbjct: 111 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 143
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 46.2 bits (108), Expect = 7e-05 Identities = 32/107 (29%), Positives = 47/107 (43%), Gaps = 1/107 (0%) Frame = +3 Query: 279 EAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD-VAIKRIKASCFDGRPSERE 455 + + L+K I + L +LG G +G V+ G W VAIK +K Sbjct: 250 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEA---- 305 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F +EAQ++ L H +V Y VV + P + V E+M GS Sbjct: 306 -----FLQEAQVMKKLRHEKLVQLYAVVSEEP---IYIVIEYMSKGS 344
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 46.2 bits (108), Expect = 7e-05 Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 2/97 (2%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 ++ D+ +LG G YG V+ G W+ VA+K +K + + +F KEA Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---------VEEFLKEA 333 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++ + HPN+V GV P VTE+M G+ Sbjct: 334 AVMKEIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGN 368
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 46.2 bits (108), Expect = 7e-05 Identities = 30/94 (31%), Positives = 47/94 (50%), Gaps = 2/94 (2%) Frame = +3 Query: 309 TIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKE 482 T + +++++LG GTY +V+ G+ R G VA+K I +G PS R E Sbjct: 2 TGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIR-------E 54 Query: 483 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 ++ L H N+V+ Y V+ + L V EFM Sbjct: 55 ISLMKELDHENIVTLYDVIH--TENKLTLVFEFM 86
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 46.2 bits (108), Expect = 7e-05 Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 2/94 (2%) Frame = +3 Query: 309 TIKNDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKE 482 T + +++++LG GTY +V+ G+ R G VA+K I +G PS R E Sbjct: 2 TGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIR-------E 54 Query: 483 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 ++ L H N+V+ Y V+ + L V E+M Sbjct: 55 ISLMKELDHENIVTLYDVIH--TENKLTLVFEYM 86
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 46.2 bits (108), Expect = 7e-05 Identities = 36/95 (37%), Positives = 48/95 (50%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +GSG +G V G+ R VAIK +K+ G E+ R +F EA I Sbjct: 639 IEEV--IGSGEFGEVCFGRLKHPGKREYTVAIKTLKS----GYTDEQRR---EFLSEASI 689 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPNV+ GVV + VTEFM NGS Sbjct: 690 MGQFEHPNVIHLEGVVT--KSRPVMIVTEFMENGS 722
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 46.2 bits (108), Expect = 7e-05 Identities = 24/70 (34%), Positives = 42/70 (60%) Frame = +3 Query: 324 DLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 +++ +K +G+G++G+VF G+W G DVA+K +K S +P+ + F E Q+L Sbjct: 309 EVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVS----QPTAEQ--AQAFKNEMQVLRKT 361 Query: 504 HHPNVVSFYG 533 H N++ F G Sbjct: 362 RHVNILLFMG 371
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 46.2 bits (108), Expect = 7e-05 Identities = 34/135 (25%), Positives = 62/135 (45%), Gaps = 14/135 (10%) Frame = +3 Query: 171 DKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKN---------- 320 D G+ D G P S + S + + E ++L+ + +KN Sbjct: 242 DAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYW 301 Query: 321 ----DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 +++ +K +G+G++G+VF G+W G DVA+K +K + +P+ + F E Q Sbjct: 302 EVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QPTAEQ--AQAFKNEMQ 354 Query: 489 ILSSLHHPNVVSFYG 533 +L H N++ F G Sbjct: 355 VLRKTRHVNILLFMG 369
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 45.8 bits (107), Expect = 9e-05 Identities = 39/150 (26%), Positives = 66/150 (44%), Gaps = 14/150 (9%) Frame = +3 Query: 126 VQPDARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGL 305 VQ A+ N+ N G D G P S + S S E ++L+ Sbjct: 232 VQLTAQSFNTDAAGNRGGG---DGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDK 288 Query: 306 QTIKN--------------DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRP 443 + +KN +++ +K +G+G++G+VF G+W G DVA+K +K + +P Sbjct: 289 KKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVA----QP 343 Query: 444 SERERLIADFWKEAQILSSLHHPNVVSFYG 533 + + F E Q+L H N++ F G Sbjct: 344 TAEQ--AQAFKNEMQVLRKTRHVNILLFMG 371
>PR2_DROME (Q9I7F7) Tyrosine-protein kinase PR2 (EC 2.7.10.2)| Length = 1337 Score = 45.8 bits (107), Expect = 9e-05 Identities = 35/93 (37%), Positives = 47/93 (50%), Gaps = 4/93 (4%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIK-RIKASCFDGRPSERERLIA---DFWK 479 I D + K+LG+G +G V G W + I+ IK C RER+ + +F K Sbjct: 128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLC-------RERMQSNPMEFLK 180 Query: 480 EAQILSSLHHPNVVSFYGVVRDGPDGSLATVTE 578 EA I+ S+ H N+V YGVV SL VTE Sbjct: 181 EAAIMHSIEHENIVRLYGVVL--ATDSLMLVTE 211
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/95 (32%), Positives = 47/95 (49%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E I ELG+G G V + R + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKARHRPSGFIMAR-KLIHLEIKPAVRNQII----RELQV 121 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYG DG ++ E M GS Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 154
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 45.4 bits (106), Expect = 1e-04 Identities = 37/101 (36%), Positives = 51/101 (50%), Gaps = 6/101 (5%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFW 476 + N +E + +G+G +G V G+ R VAIK +KA SE +R DF Sbjct: 623 VSNIRIERV--IGAGEFGEVCSGRLRLPSKREIQVAIKSLKAGY-----SEHQR--RDFL 673 Query: 477 KEAQILSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGS 596 EA I+ HPN++ GVV R P + VTE+M NGS Sbjct: 674 SEASIMGQFDHPNIIRLEGVVTRCKP---VMIVTEYMENGS 711
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 45.4 bits (106), Expect = 1e-04 Identities = 46/156 (29%), Positives = 63/156 (40%), Gaps = 4/156 (2%) Frame = +3 Query: 117 PVEVQP--DARPANSPVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEA 290 P+E+ P D RP +SPV KDGK F T S P Sbjct: 12 PLELSPSADLRPCSSPVVIPGKDGKAFLGGTP---------------SPRTRRLPPRLAW 56 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD 470 S I D L ++ LGSG +G+V+ + G VA+K++K S + S + Sbjct: 57 CS-----IDWDRLCLLQPLGSGGFGAVYKATYHGVTVAVKQVKKSSKNRLASRQ-----S 106 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGP--DGSLATV 572 FW E + + L H NVV P SL T+ Sbjct: 107 FWAELNV-ARLQHDNVVRVVAASTCAPASQNSLGTI 141
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/89 (31%), Positives = 46/89 (51%), Gaps = 2/89 (2%) Frame = +3 Query: 330 EEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 ++++++G+GTY +V+ G K G VA+K +K +G PS R E ++ L Sbjct: 8 KQLEKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-------EISLMKEL 60 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVN 590 H N+V + V+ + L V EFM N Sbjct: 61 KHDNIVRLFDVIH--TENKLTLVFEFMDN 87
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G K G V +K+I+ SE E + + +E +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVTMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+VS V+ D L + EF+ Sbjct: 56 KELRHPNIVSLQDVLMQ--DSRLYLIFEFL 83
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 45.4 bits (106), Expect = 1e-04 Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 DD +I+++G GTYG V+ G K G VA+K+I+ SE E + + +E +L Sbjct: 2 DDYLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLE------SEEEGVPSTAVREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPNVV V+ + L V EF+ Sbjct: 56 KELQHPNVVRLLDVLMQ--ESKLYLVFEFL 83
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/77 (35%), Positives = 42/77 (54%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 500 +++ E++ LGSG G+VF GK+R +VAIK++ RE+ D + L Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDI----KHLRK 210 Query: 501 LHHPNVVSFYGVVRDGP 551 L HPN+++F GV P Sbjct: 211 LKHPNIIAFKGVCTQAP 227
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/77 (35%), Positives = 42/77 (54%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 500 +++ E++ LGSG G+VF GK+R +VAIK++ RE+ D + L Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDI----KHLRK 210 Query: 501 LHHPNVVSFYGVVRDGP 551 L HPN+++F GV P Sbjct: 211 LKHPNIIAFKGVCTQAP 227
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 45.4 bits (106), Expect = 1e-04 Identities = 47/190 (24%), Positives = 84/190 (44%), Gaps = 4/190 (2%) Frame = +3 Query: 39 ISENRLNFLPEFVASVK--KAALEESEKPVEVQPDARPANSPVCDNDKDGKKFDENTDGD 212 +SE+ ++P V ++ +AA + S K P P++S V +++ + T + Sbjct: 121 VSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPF--PSSSGVSNSNNNRTS---TTATE 175 Query: 213 QDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG 392 + P + + H S+ + + E L+ D LG G +G V+ GKW+ Sbjct: 176 EIPSLESLGNIHISTVQRAAESLLEIDYAELENA-TDGWSPDNRLGQGGFGDVYRGKWKQ 234 Query: 393 CDVAIK--RIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLA 566 DVAIK ++ D + E + + E + L+S+ H N+++ YG G G Sbjct: 235 LDVAIKVMNYRSPNIDQKMVE----LQQSYNELKYLNSIRHDNILALYGYSIKG--GKPC 288 Query: 567 TVTEFMVNGS 596 V + M GS Sbjct: 289 LVYQLMKGGS 298
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 7/101 (6%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCD-------VAIKRIKASCFDGRPSERERLIAD 470 IK D+ ELG G +G VF + VA+K +K + + R D Sbjct: 508 IKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQ--------D 559 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 F +EA++L+ L H ++V F+GV +G G L V E+M +G Sbjct: 560 FHREAELLTMLQHQHIVRFFGVCTEG--GPLLMVFEYMRHG 598
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/115 (26%), Positives = 52/115 (45%), Gaps = 3/115 (2%) Frame = +3 Query: 261 IESTPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCF 431 +ES E SKG + DL ++ + SG + ++ G ++ VA+K ++ Sbjct: 61 LESENVETWEASKGEREEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTH 120 Query: 432 DGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + R +L F E +LS L HPN+V F + P +TE+M G+ Sbjct: 121 --KEETRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKPP--VYCIITEYMSQGN 171
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 3/98 (3%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGC--DVAIKRIKASCFDGRPSERERLIADFWKEA 485 + NDD+ ++ +G G +G V+ K + DVA+K +C P E++R F +E Sbjct: 1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVK----TCRMTLPDEQKR---KFLQEG 1110 Query: 486 QILSSLHHPNVVSFYGV-VRDGPDGSLATVTEFMVNGS 596 +IL HPN+V G+ V+ P + V E ++ GS Sbjct: 1111 RILKQYDHPNIVKLIGICVQKQP---IMIVMELVLGGS 1145
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/98 (32%), Positives = 49/98 (50%), Gaps = 3/98 (3%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGS---VFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKE 482 +KN+DL+ + ELG+G G+ V H K + K D +PS R++++ +E Sbjct: 104 LKNEDLKTLSELGAGNGGTVTKVLHEK----SGTVMAKKVVFIDAKPSVRKQIL----RE 155 Query: 483 AQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 QIL + P +VSFYG + P + EFM S Sbjct: 156 LQILHECNSPYIVSFYGAYLNEP--HICMCMEFMQKDS 191
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 2/90 (2%) Frame = +3 Query: 333 EIKEL-GSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSLH 506 E+KEL G+G +G V+ W+G +VA+K + P + A+ +EA++ + L Sbjct: 125 ELKELIGAGGFGQVYRATWQGQEVAVKAARQD-----PEQDAAAAAESVRREARLFAMLR 179 Query: 507 HPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GV P L V EF G+ Sbjct: 180 HPNIIELRGVCLQQP--HLCLVLEFARGGA 207
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 44.7 bits (104), Expect = 2e-04 Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 2/98 (2%) Frame = +3 Query: 249 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKA 422 + SGI T A+ K + ++D+ + +G G +G VF G+ R + VA+K Sbjct: 250 RKSGIVLT----RAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVK---- 301 Query: 423 SCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 536 SC + P E L A F +EA+IL +HPN+V GV Sbjct: 302 SCRETLPPE---LKAKFLQEARILKQYNHPNIVRLIGV 336
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 2/88 (2%) Frame = +3 Query: 339 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 512 K LG G +G V+ + G ++A K+++ FD E + ++ E Q+L +L H Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQ---FDPDSPETSKEVSALECEIQLLKNLQHE 422 Query: 513 NVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +V +YG +RD + +L E+M GS Sbjct: 423 RIVQYYGCLRDRAEKTLTIFMEYMPGGS 450
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 2/88 (2%) Frame = +3 Query: 339 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 512 K LG G +G V+ + G ++A+K+++ FD E + + E Q+L +L H Sbjct: 360 KLLGQGAFGRVYLCYDVDTGRELAVKQVQ---FDPDSPETSKEVNALECEIQLLKNLLHE 416 Query: 513 NVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +V +YG +RD + +L+ E+M GS Sbjct: 417 RIVQYYGCLRDPQEKTLSIFMEYMPGGS 444
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 2/78 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 D+ + +++G GTYG V+ + G DVA+K+I+ E E + + +E +L Sbjct: 6 DNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLE------GETEGVPSTAIREISLL 59 Query: 495 SSLHHPNVVSFYGVVRDG 548 +L HPNVV + VV G Sbjct: 60 KNLKHPNVVQLFDVVISG 77
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/108 (27%), Positives = 53/108 (49%) Frame = +3 Query: 270 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSE 449 TP+ L+ +K +L+ +K LGSG +G+V+ G W +K I + + Sbjct: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETT 757 Query: 450 RERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 + +F EA I++S+ HP++V GV ++ VT+ M +G Sbjct: 758 GPKANVEFMDEALIMASMDHPHLVRLLGVCL---SPTIQLVTQLMPHG 802
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 44.7 bits (104), Expect = 2e-04 Identities = 35/96 (36%), Positives = 51/96 (53%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V GK + VAIK +KA +E++R DF EA I Sbjct: 611 IEEV--IGAGEFGEVCRGKLKQAGRREQFVAIKTLKAGY-----TEQQR--RDFLGEASI 661 Query: 492 LSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGS 596 + HPN++ GVV R P + +TEFM NG+ Sbjct: 662 MGQFDHPNIIRLEGVVTRSRP---VMILTEFMENGA 694
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 44.7 bits (104), Expect = 2e-04 Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 2/98 (2%) Frame = +3 Query: 249 KSSGIESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKA 422 + SGI T A+ K + ++D+ + +G G +G VF G+ R + VA+K Sbjct: 590 RKSGIVLT----RAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVK---- 641 Query: 423 SCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 536 SC + P E L A F +EA+IL +HPN+V GV Sbjct: 642 SCRETLPPE---LKAKFLQEARILKQCNHPNIVRLIGV 676
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 44.7 bits (104), Expect = 2e-04 Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + L Sbjct: 548 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---L 600 Query: 462 IADFWKEAQILSSLHHPNVVSFYGV 536 A F +EA+IL HPN+V GV Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGV 625
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/95 (32%), Positives = 48/95 (50%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E I ELG+G G V + R + + R K + +P+ R ++I +E Q+ Sbjct: 67 LKDDDFERISELGAGNGGVVTKVQHRPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 121 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYG DG ++ E M GS Sbjct: 122 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 154
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/91 (35%), Positives = 46/91 (50%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G+G +G V G+ + VAIK +KA +E++R DF EA I+ Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGY-----TEKQR--RDFLGEASIMGQF 677 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + VTE+M NGS Sbjct: 678 DHPNIIRLEGVVTKSK--PVMIVTEYMENGS 706
>ACK1_MOUSE (O54967) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1)| (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Length = 1055 Score = 44.3 bits (103), Expect = 3e-04 Identities = 28/95 (29%), Positives = 42/95 (44%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 I DL +++LG G++G V G+W + C + + DF +E Sbjct: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + SL H N++ YGVV P + VTE GS Sbjct: 181 MHSLDHRNLIRLYGVVLTLP---MKMVTELAPLGS 212
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 44.3 bits (103), Expect = 3e-04 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 437 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDL 130 Query: 438 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 R S+R FW E I + L H N+V P+ S + T M G Sbjct: 131 RASQR-----SFWAELNI-AGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFG 176
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 44.3 bits (103), Expect = 3e-04 Identities = 30/108 (27%), Positives = 53/108 (49%) Frame = +3 Query: 270 TPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSE 449 TP+ L+ +K +L+ +K LGSG +G+V+ G W +K I + + Sbjct: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETT 757 Query: 450 RERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 + +F EA I++S+ HP++V GV ++ VT+ M +G Sbjct: 758 GPKANVEFMDEALIMASVDHPHLVRLLGVCL---SPTIQLVTQLMPHG 802
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 44.3 bits (103), Expect = 3e-04 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 437 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 52 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDL 110 Query: 438 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 R S+R FW E I + L H N+V P+ S + T M G Sbjct: 111 RASQR-----SFWAELNI-AGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFG 156
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + + Sbjct: 335 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---I 387 Query: 462 IADFWKEAQILSSLHHPNVVSFYGV 536 A F +EA+IL HPN+V GV Sbjct: 388 KAKFLQEAKILKQYSHPNIVRLIGV 412
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 43.9 bits (102), Expect = 4e-04 Identities = 35/108 (32%), Positives = 49/108 (45%), Gaps = 15/108 (13%) Frame = +3 Query: 273 PAEAEALSKGLQTIKNDDLEEI---------KELGSGTYGSVFHGKW-----RGCDVAIK 410 P KG QT+KN+ + I KELG G +GSV G W + +VA+K Sbjct: 457 PNSVNVGQKGDQTMKNNAQQNIILKESISFGKELGVGEFGSVIKGIWLSPGGKEINVAMK 516 Query: 411 RI-KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGP 551 + K G +F +EA ++S L+HP +VS GV P Sbjct: 517 TLHKDKMVQGE--------KEFLREALVMSQLNHPCIVSLLGVCLGPP 556
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 43.9 bits (102), Expect = 4e-04 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 437 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 41 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 99 Query: 438 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 R S+R FW E I + L H N+V P+ S + T M G Sbjct: 100 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFG 145
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 43.9 bits (102), Expect = 4e-04 Identities = 28/90 (31%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 D+ +I+++G GTYG V+ G+ + G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+V V+ D L + EF+ Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEFL 83
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 43.9 bits (102), Expect = 4e-04 Identities = 28/90 (31%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 D+ +I+++G GTYG V+ G+ + G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+V V+ D L + EF+ Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEFL 83
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 43.9 bits (102), Expect = 4e-04 Identities = 35/90 (38%), Positives = 50/90 (55%), Gaps = 2/90 (2%) Frame = +3 Query: 333 EIKELGSGTYGSVFHGKWR-GCDVAIKR-IKASCFDGRPSERERLIADFWKEAQILSSLH 506 E ++G G++ VF G R G VA+KR IKAS D + S +E F E +LS L+ Sbjct: 507 EDSQVGKGSFSCVFKGILRDGTVVAVKRAIKAS--DVKKSSKE-----FHNELDLLSRLN 559 Query: 507 HPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 H ++++ G DG + L V EFM +GS Sbjct: 560 HAHLLNLLGYCEDGSERLL--VYEFMAHGS 587
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 43.9 bits (102), Expect = 4e-04 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 437 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 130 Query: 438 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 R S+R FW E I + L H N+V P+ S + T M G Sbjct: 131 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFG 176
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 43.9 bits (102), Expect = 4e-04 Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V G+ + VAIK +K G +ER+R +F EA I Sbjct: 617 IEEV--IGAGEFGEVCRGRLKAPGKKESCVAIKTLK-----GGYTERQR--REFLSEASI 667 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + + +TEFM NG+ Sbjct: 668 MGQFEHPNIIRLEGVVTNSV--PVMILTEFMENGA 700
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 43.9 bits (102), Expect = 4e-04 Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 5/95 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V G+ + VAIK +K G +ER+R +F EA I Sbjct: 617 IEEV--IGAGEFGEVCRGRLKAPGKKESCVAIKTLK-----GGYTERQR--REFLSEASI 667 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 + HPN++ GVV + + +TEFM NG+ Sbjct: 668 MGQFEHPNIIRLEGVVTNSM--PVMILTEFMENGA 700
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 43.9 bits (102), Expect = 4e-04 Identities = 28/84 (33%), Positives = 45/84 (53%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K + D P + + F E +L H N++ Sbjct: 346 IGSGSFGTVYKGKWHG-DVAVKILKVT--DPTPEQ----LQAFRNEVAVLRKTRHVNILL 398 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 399 FMGYM---TKDNLAIVTQWCEGSS 419
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 43.9 bits (102), Expect = 4e-04 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 437 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 88 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 146 Query: 438 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 R S+R FW E I + L H N+V P+ S + T M G Sbjct: 147 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFG 192
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + + Sbjct: 203 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---I 255 Query: 462 IADFWKEAQILSSLHHPNVVSFYGV 536 A F +EA+IL HPN+V GV Sbjct: 256 KAKFLQEAKILKQYSHPNIVRLIGV 280
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +3 Query: 288 ALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGCD--VAIKRIKASCFDGRPSERERL 461 A+ K + ++DL +++G G +G VF G+ R + VA+K SC + P + + Sbjct: 546 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPD---I 598 Query: 462 IADFWKEAQILSSLHHPNVVSFYGV 536 A F +EA+IL HPN+V GV Sbjct: 599 KAKFLQEAKILKQYSHPNIVRLIGV 623
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 43.9 bits (102), Expect = 4e-04 Identities = 35/96 (36%), Positives = 50/96 (52%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V G+ + VAIK +KA +E +R DF EA I Sbjct: 189 IEEV--IGAGEFGEVCRGRLKQAGRKETTVAIKTLKAGY-----TEHQR--RDFLSEASI 239 Query: 492 LSSLHHPNVVSFYGVV-RDGPDGSLATVTEFMVNGS 596 + HPNV+ GV+ R P + VTEFM NG+ Sbjct: 240 MGQFDHPNVIHLEGVLTRSCP---VLIVTEFMENGA 272
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 43.9 bits (102), Expect = 4e-04 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Frame = +3 Query: 267 STPAEAEALSKGLQTIKNDDLEEI---KELGSGTYGSVFHGKWRGCDVAIKRIKASCFDG 437 +TP A L + L + D E++ LGSG +GSV+ + G VAIK++ D Sbjct: 72 TTPPRAPGLPRRLAWF-SIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDL 130 Query: 438 RPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 R S+R FW E I + L H N+V P+ S + T M G Sbjct: 131 RASQR-----SFWAELNI-ARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFG 176
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 43.9 bits (102), Expect = 4e-04 Identities = 39/151 (25%), Positives = 62/151 (41%), Gaps = 4/151 (2%) Frame = +3 Query: 156 PVCDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEE 335 P CD D+ +N + P S ++KS + T + + + N D Sbjct: 126 PFCDKDRTLMTPVQNLEQSYMPP-DSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 184 Query: 336 IK----ELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 I ++G G +G V+ G VA+K++ A E L F +E ++++ Sbjct: 185 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMV----DITTEELKQQFDQEIKVMAKC 240 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 H N+V G DG D L V +M NGS Sbjct: 241 QHENLVELLGFSSDGDD--LCLVYVYMPNGS 269
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 43.9 bits (102), Expect = 4e-04 Identities = 28/91 (30%), Positives = 46/91 (50%), Gaps = 2/91 (2%) Frame = +3 Query: 318 NDDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 + +++++LG GTY +V+ G+ R G VA+K I +G PS R E + Sbjct: 4 SSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIR-------EISL 56 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 + L H N+V+ Y V+ + L V E+M Sbjct: 57 MKELKHENIVTLYDVIH--TENKLNLVFEYM 85
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 43.5 bits (101), Expect = 5e-04 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 645 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 697 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNV+ GVV + +TEFM NGS Sbjct: 698 PNVIHLEGVVT--KSSPVMIITEFMENGS 724
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 43.5 bits (101), Expect = 5e-04 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 628 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 680 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNV+ GVV + +TEFM NGS Sbjct: 681 PNVIHLEGVVT--KSSPVMIITEFMENGS 707
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 43.5 bits (101), Expect = 5e-04 Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 2/88 (2%) Frame = +3 Query: 339 KELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHP 512 K LG G +G V+ + G ++A K+++ FD E + ++ E Q+L +L H Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQ---FDPDSPETSKEVSALECEIQLLKNLQHE 422 Query: 513 NVVSFYGVVRDGPDGSLATVTEFMVNGS 596 +V +YG +RD + L E+M GS Sbjct: 423 RIVQYYGCLRDRAEKILTIFMEYMPGGS 450
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHG--KWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 D+ +I+++G GTYG V+ G K G VA+K+I+ +E E + + +E +L Sbjct: 2 DEYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLE------NEEEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPN+V V+ D L + EF+ Sbjct: 56 KELQHPNIVCLLDVLMQ--DSRLYLIFEFL 83
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPNVV V+ + L + EF+ Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL 83
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPNVV V+ + L + EF+ Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL 83
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPNVV V+ + L + EF+ Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL 83
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 +D +I+++G GTYG V+ G+ + G VA+K+I+ SE E + + +E +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLE------SEEEGVPSTAVREVSLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L HPNVV V+ + L + EF+ Sbjct: 56 QELKHPNVVRLLDVLMQ--ESRLYLIFEFL 83
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 1/90 (1%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSL 503 LEE+ +G G +G V+ G WRG VA+K + P E + A+ +EA++ + L Sbjct: 119 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQD-----PDEDISVTAESVRQEARLFAML 171 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 HPN+++ V + P +L V E+ G Sbjct: 172 AHPNIIALKAVCLEEP--NLCLVMEYAAGG 199
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 43.1 bits (100), Expect = 6e-04 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 635 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 687 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNV+ GVV + +TEFM NGS Sbjct: 688 PNVIHLEGVVTKST--PVMIITEFMENGS 714
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 43.1 bits (100), Expect = 6e-04 Identities = 30/95 (31%), Positives = 48/95 (50%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +K+DD E I ELG+G G V + + + + R K + +P+ R ++I +E Q+ Sbjct: 65 LKDDDFERISELGAGNGGVVTKVQHKPSGLIMAR-KLIHLEIKPAIRNQII----RELQV 119 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P +V FYG DG ++ E M GS Sbjct: 120 LHECNSPYIVGFYGAFYS--DGEISICMEHMDGGS 152
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 43.1 bits (100), Expect = 6e-04 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 + ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V + V+ + L V EF+ Sbjct: 56 KELNHPNIVKLHDVIH--TENKLYLVFEFL 83
>FAK1_XENLA (Q91738) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1068 Score = 43.1 bits (100), Expect = 6e-04 Identities = 44/182 (24%), Positives = 79/182 (43%), Gaps = 11/182 (6%) Frame = +3 Query: 39 ISENRLNFLPEFVASVKKAALEESEKPVEVQPDARPANSPVCDNDKDGKK-----FDENT 203 I+EN + + + V A+ +P + A P+ + +N+K G + + Sbjct: 336 IAENMADLIDGYCRLVSGASESFIIRPQKEGERALPSIPKLANNEKHGVRPHAVSVSDEF 395 Query: 204 DGDQDPDVHGSCDQHKSSGIESTPAEAEALSK-GLQTIKNDDLEEIKELGSGTYGSVFHG 380 GD+ D D+ + + P+++ L + G I+ D +E + +G G +G V G Sbjct: 396 SGDETDDYAEIIDEEDTY---TMPSKSYGLDEAGDYEIQRDRIELGRCIGEGQFGDVHQG 452 Query: 381 KWRGCD-----VAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGVVRD 545 + + VAIK K D S RE+ F +EA + HP++V GV+ + Sbjct: 453 VYMSPENPAMAVAIKTCKNCTSD---SVREK----FLQEALTMRQFDHPHIVKLIGVITE 505 Query: 546 GP 551 P Sbjct: 506 NP 507
>TOPK_HUMAN (Q96KB5) T-lymphokine-activated killer cell-originated protein| kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3) Length = 322 Score = 43.1 bits (100), Expect = 6e-04 Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 10/92 (10%) Frame = +3 Query: 336 IKELGSGTYGSVF----------HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEA 485 +++LG GT +V+ H W A+K+I C D S ++ + D EA Sbjct: 35 MQKLGFGTGVNVYLMKRSPRGLSHSPW-----AVKKINPICNDHYRSVYQKRLMD---EA 86 Query: 486 QILSSLHHPNVVSFYGVVRDGPDGSLATVTEF 581 +IL SLHHPN+V Y + DGSL E+ Sbjct: 87 KILKSLHHPNIVG-YRAFTEANDGSLCLAMEY 117
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 30 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 82 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 83 FMGYM---TKDNLAIVTQWCEGSS 103
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 43.1 bits (100), Expect = 6e-04 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G R VAIK +K+ +E++R DF EA I+ H Sbjct: 627 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-----TEKQR--RDFLSEASIMGQFDH 679 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNV+ GVV + +TEFM NGS Sbjct: 680 PNVIHLEGVVTKST--PVMIITEFMENGS 706
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 407 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSS 428
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQ----LQAFRNEVAVLRKTRHVNILL 407 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSS 428
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 42.7 bits (99), Expect = 8e-04 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 407 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSS 428
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 42.7 bits (99), Expect = 8e-04 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 IL SL H N+V + GV +L + E++ GS Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGS 936 Score = 32.7 bits (73), Expect = 0.81 Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 9/104 (8%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVF---------HGKWRGCDVAIKRIKASCFDGRPSERERLI 464 I+N+DL + LG GT+ +F +G+ +V +K + + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 465 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F++ A ++S L H ++V YGV G + L V EF+ GS Sbjct: 592 ESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL--VQEFVKFGS 633
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 42.7 bits (99), Expect = 8e-04 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 IL SL H N+V + GV +L + E++ GS Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGS 936 Score = 32.7 bits (73), Expect = 0.81 Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 9/104 (8%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVF---------HGKWRGCDVAIKRIKASCFDGRPSERERLI 464 I+N+DL + LG GT+ +F +G+ +V +K + + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 465 ADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F++ A ++S L H ++V YGV G + L V EF+ GS Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL--VQEFVKFGS 633
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 42.7 bits (99), Expect = 8e-04 Identities = 33/89 (37%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 691 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNVV GVV G + V EFM NG+ Sbjct: 692 PNVVHLEGVVTRGK--PVMIVIEFMENGA 718
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 42.7 bits (99), Expect = 8e-04 Identities = 33/89 (37%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 639 IGAGEFGEVCSGRLKLPGQRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 691 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNVV GVV G + V EFM NG+ Sbjct: 692 PNVVHLEGVVTRGK--PVMIVIEFMENGA 718
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 42.7 bits (99), Expect = 8e-04 Identities = 33/89 (37%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 691 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNVV GVV G + V EFM NG+ Sbjct: 692 PNVVHLEGVVTRGK--PVMIVIEFMENGA 718
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 42.7 bits (99), Expect = 8e-04 Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G+G +G V G+ + VAIK +K +E++R DF EA I+ Sbjct: 626 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-----TEKQR--RDFLGEASIMGQF 678 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + VTE+M NGS Sbjct: 679 DHPNIIRLEGVVTKSK--PVMIVTEYMENGS 707
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 42.7 bits (99), Expect = 8e-04 Identities = 31/89 (34%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 681 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-----TEKQR--RDFLGEASIMGQFDH 733 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PN++ GVV + VTE+M NGS Sbjct: 734 PNIIHLEGVVTKSK--PVMIVTEYMENGS 760
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 42.7 bits (99), Expect = 8e-04 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 1/103 (0%) Frame = +3 Query: 291 LSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRG-CDVAIKRIKASCFDGRPSERERLIA 467 ++K I + L ++LG+G +G V+ G W VA+K +K A Sbjct: 228 IAKDAWEIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSP---------A 278 Query: 468 DFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 F EA ++ L H ++V Y + D + VTE+M GS Sbjct: 279 SFLDEAGVMKKLRHKHLVQLYAICSDRE--PIYIVTEYMSGGS 319
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 42.7 bits (99), Expect = 8e-04 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 6/96 (6%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW------RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 L+ +++LG G +GSV ++ G VA+K+++ S E + DF +E + Sbjct: 849 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIE 900 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 IL SL H N+V + GV +L + E++ GS Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGS 936 Score = 33.1 bits (74), Expect = 0.62 Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 1/96 (1%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQ 488 I+N+DL + LG GT+ +F G R + K + R ++ F++ A Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAAS 599 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++S L H ++V YGV G + L V EF+ GS Sbjct: 600 MMSQLSHKHLVLNYGVCVCGEENIL--VQEFVKFGS 633
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 42.7 bits (99), Expect = 8e-04 Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 1/91 (1%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIAD-FWKEAQILSSL 503 LEEI +G G +G V+ WRG +VA+K + P + + A+ +EA++ +L Sbjct: 100 LEEI--IGVGGFGKVYRALWRGEEVAVKAARLD-----PEKDPAVTAEQVCQEARLFGAL 152 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN+++ G + P L V E+ G+ Sbjct: 153 QHPNIIALRGACLNPP--HLCLVMEYARGGA 181
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 42.7 bits (99), Expect = 8e-04 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 88 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 140 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 141 FMGYM---TKDNLAIVTQWCEGSS 161
>E2AK1_SCHPO (O13889) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor 1) Length = 704 Score = 42.7 bits (99), Expect = 8e-04 Identities = 24/71 (33%), Positives = 41/71 (57%), Gaps = 2/71 (2%) Frame = +3 Query: 324 DLEEIKELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 497 D EE++ LG G YGSV+ K+ G + A+K+I S ++ ++E++ L+ Sbjct: 223 DFEELELLGKGGYGSVYKARNKFDGVEYALKKIPLRLRSFSTS------SNIFRESRTLA 276 Query: 498 SLHHPNVVSFY 530 L+HPNV+ F+ Sbjct: 277 RLNHPNVIRFF 287
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 42.7 bits (99), Expect = 8e-04 Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G+G +G V G+ + VAIK +K +E++R DF EA I+ Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-----TEKQR--RDFLGEASIMGQF 677 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + VTE+M NGS Sbjct: 678 DHPNIIRLEGVVTKSKPEMI--VTEYMENGS 706
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 42.7 bits (99), Expect = 8e-04 Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWR-----GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G+G +G V G+ + VAIK +K +E++R DF EA I+ Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-----TEKQR--RDFLGEASIMGQF 677 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + VTE+M NGS Sbjct: 678 DHPNIIRLEGVVTKSK--PVMIVTEYMENGS 706
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 42.7 bits (99), Expect = 8e-04 Identities = 28/84 (33%), Positives = 44/84 (52%) Frame = +3 Query: 345 LGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVS 524 +GSG++G+V+ GKW G DVA+K +K D P + + F E +L H N++ Sbjct: 355 IGSGSFGTVYKGKWHG-DVAVKILKV--VDPTPEQFQA----FRNEVAVLRKTRHVNILL 407 Query: 525 FYGVVRDGPDGSLATVTEFMVNGS 596 F G + +LA VT++ S Sbjct: 408 FMGYM---TKDNLAIVTQWCEGSS 428
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 42.7 bits (99), Expect = 8e-04 Identities = 33/94 (35%), Positives = 47/94 (50%), Gaps = 10/94 (10%) Frame = +3 Query: 342 ELGSGTYGSVFHGKWRGCD----------VAIKRIKASCFDGRPSERERLIADFWKEAQI 491 ELG G +G VF + C VA+K +K +E RL DF +EA++ Sbjct: 498 ELGEGAFGKVFLAE---CSHLLPEQEKTLVAVKALK------EVTENARL--DFQREAEL 546 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 L+ L H ++V FYGV +G L V E+M +G Sbjct: 547 LTVLQHEHIVKFYGVCTEG--DPLIMVFEYMKHG 578
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 42.4 bits (98), Expect = 0.001 Identities = 31/89 (34%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 657 IGAGEFGEVCSGRLKLQGKREFPVAIKTLKVGY-----TEKQR--RDFLGEASIMGQFDH 709 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PN++ GVV + VTE+M NGS Sbjct: 710 PNIIHLEGVVTKSK--PVMIVTEYMENGS 736
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 42.4 bits (98), Expect = 0.001 Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 7/101 (6%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVF----HGKWRGCD---VAIKRIKASCFDGRPSERERLIAD 470 IK D+ ELG G +G VF H D VA+K +K + R D Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ--------D 556 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 F +EA++L+ L H ++V F+GV +G L V E+M +G Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHG 595
>TOPK_BRARE (Q6DHU8) T-lymphokine-activated killer cell-originated protein| kinase homolog (EC 2.7.12.2) (PDZ-binding kinase) Length = 339 Score = 42.4 bits (98), Expect = 0.001 Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 4/86 (4%) Frame = +3 Query: 336 IKELGSGTYGSVF----HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 +K+LG GT +V+ GK AIK+I + C G+ S ++ + + EA+IL L Sbjct: 39 MKKLGCGTGVNVYLMNRMGKQTHSPWAIKKINSKCAQGQVSVYQKRLCE---EAKILKDL 95 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEF 581 HPN+V F DGS EF Sbjct: 96 KHPNIVGFRAFT-TAKDGSKCLAMEF 120
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 42.0 bits (97), Expect = 0.001 Identities = 31/86 (36%), Positives = 42/86 (48%), Gaps = 2/86 (2%) Frame = +3 Query: 345 LGSGTYGSVFHGKW--RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 518 LG G +G V+ G+ G VA+K++ + G +F E +LS LHHPN+ Sbjct: 92 LGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGN--------REFLVEVLMLSLLHHPNL 143 Query: 519 VSFYGVVRDGPDGSLATVTEFMVNGS 596 V+ G DG L V EFM GS Sbjct: 144 VNLIGYCADGDQRLL--VYEFMPLGS 167
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 625 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 677 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + +TE+M NGS Sbjct: 678 DHPNIIHLEGVVTKCK--PVMIITEYMENGS 706
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 625 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 677 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + +TE+M NGS Sbjct: 678 DHPNIIHLEGVVTKCK--PVMIITEYMENGS 706
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 625 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 677 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + +TE+M NGS Sbjct: 678 DHPNIIHLEGVVTKCK--PVMIITEYMENGS 706
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 624 KVIGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 676 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + +TE+M NGS Sbjct: 677 DHPNIIHLEGVVTKCK--PVMIITEYMENGS 705
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 42.0 bits (97), Expect = 0.001 Identities = 27/86 (31%), Positives = 45/86 (52%), Gaps = 2/86 (2%) Frame = +3 Query: 345 LGSGTYGSVFHGKW--RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 518 +G G +G V+ G G +AIK++ + + + I + +E Q+L +L HPN+ Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNI 133 Query: 519 VSFYGVVRDGPDGSLATVTEFMVNGS 596 V + G VR+ SL + EF+ GS Sbjct: 134 VRYLGTVRE--SDSLNILMEFVPGGS 157
>KSR2_HUMAN (Q6VAB6) Kinase suppressor of ras-2 (hKSR2)| Length = 829 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/103 (31%), Positives = 46/103 (44%), Gaps = 2/103 (1%) Frame = +3 Query: 267 STPAEAEALSKGLQT--IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGR 440 S P +A S LQ I + LE + +G G +G V+HG+W G +VAI+ I Sbjct: 523 SFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIE----- 576 Query: 441 PSERERLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLAT 569 + E + F +E H NVV F G P ++ T Sbjct: 577 -RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIIT 618
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 42.0 bits (97), Expect = 0.001 Identities = 34/102 (33%), Positives = 46/102 (45%), Gaps = 9/102 (8%) Frame = +3 Query: 249 KSSGIESTPAEAEALSKGLQT-------IKNDDLEEIKELGSGTYGSVFHGK--WRGCDV 401 K S ES+P + E S+G + K LG+GT+G V K G DV Sbjct: 4 KVSEKESSPKQTEEDSEGKMAHVQPASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDV 63 Query: 402 AIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSF 527 A+K + G + E L + E IL LHHPN+V+F Sbjct: 64 AVKILIKKALKGNKVQLEAL----YDELDILQRLHHPNIVAF 101
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 42.0 bits (97), Expect = 0.001 Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 1/90 (1%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSER-ERLIADFWKEAQILSSL 503 LEEI +G G +G V+ W G +VA+K + P E + I + +EA++ + L Sbjct: 146 LEEI--IGIGGFGKVYRAFWIGDEVAVKAARHD-----PDEDISQTIENVRQEAKLFAML 198 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 HPN+++ GV P +L V EF G Sbjct: 199 KHPNIIALRGVCLKEP--NLCLVMEFARGG 226
>MOS_HUMAN (P00540) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/86 (32%), Positives = 41/86 (47%) Frame = +3 Query: 336 IKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPN 515 ++ LG+G +GSV+ +RG VAIK++ C R + R FW E + + L H N Sbjct: 63 LQRLGAGGFGSVYKATYRGVPVAIKQVN-KCTKNRLASRR----SFWAELNV-ARLRHDN 116 Query: 516 VVSFYGVVRDGPDGSLATVTEFMVNG 593 +V P GS + T M G Sbjct: 117 IVRVVAASTRTPAGSNSLGTIIMEFG 142
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 5/91 (5%) Frame = +3 Query: 339 KELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 K +G G +G V G+ R VAIK +KA D ++R DF EA I+ Sbjct: 624 KVIGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTD-----KQR--RDFLSEASIMGQF 676 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 HPN++ GVV + +TE+M NGS Sbjct: 677 DHPNIIHLEGVVTKCK--PVMIITEYMENGS 705
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/86 (29%), Positives = 47/86 (54%), Gaps = 2/86 (2%) Frame = +3 Query: 345 LGSGTYGSVFHGKW--RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 518 +G G +G+V+ G G +A+K++ + + + I + +E ++L +L HPN+ Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 134 Query: 519 VSFYGVVRDGPDGSLATVTEFMVNGS 596 V + G VR+ D +L + EF+ GS Sbjct: 135 VRYLGTVRE--DDTLNILLEFVPGGS 158
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 42.0 bits (97), Expect = 0.001 Identities = 34/106 (32%), Positives = 48/106 (45%), Gaps = 7/106 (6%) Frame = +3 Query: 297 KGLQTIKNDDLEEIKELGSGTYG------SVFHGKWRGCDVAIKR-IKASCFDGRPSERE 455 K + +N E I+ LGSGT+ V GKW + KR I + + R +E Sbjct: 157 KNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEM- 215 Query: 456 RLIADFWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 F +E IL SLHHP VV + + + D L V E++ G Sbjct: 216 -----FQREIDILKSLHHPGVVQCHEIFEN--DDELFIVMEYVEGG 254
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 42.0 bits (97), Expect = 0.001 Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 7/93 (7%) Frame = +3 Query: 339 KELGSGTYGSV-----FHGKWRG--CDVAIKRIKASCFDGRPSERERLIADFWKEAQILS 497 K LG G +G V FH K R VA+K +K + PSE L+++F +L Sbjct: 728 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA---SPSELRDLLSEF----NVLK 780 Query: 498 SLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 ++HP+V+ YG DG L + E+ GS Sbjct: 781 QVNHPHVIKLYGAC--SQDGPLLLIVEYAKYGS 811
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 2/87 (2%) Frame = +3 Query: 330 EEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 + +++LG GTY V+ G+ R G VA+K I+ +G PS R E ++ L Sbjct: 4 QRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEGTPSTAIR-------EISLMKEL 56 Query: 504 HHPNVVSFYGVVRDGPDGSLATVTEFM 584 HPN++S V++ + L V E+M Sbjct: 57 RHPNIMSLSDVLQ--TENKLMLVFEYM 81
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 41.6 bits (96), Expect = 0.002 Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VA K +K +E++R DF EA I+ H Sbjct: 683 IGAGEFGEVCSGRLKLPGKRELPVATKTLKVGY-----TEKQR--RDFLSEASIMGQFDH 735 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PN++ GVV + VTE+M NGS Sbjct: 736 PNIIHLEGVVTKSK--PVMIVTEYMENGS 762
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 41.6 bits (96), Expect = 0.002 Identities = 42/161 (26%), Positives = 67/161 (41%), Gaps = 17/161 (10%) Frame = +3 Query: 162 CDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKND-----D 326 C + K F + + +G +K+S E A++ G+ K + Sbjct: 2 CSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNS-------EDLAINPGMYVRKKEGKIGES 54 Query: 327 LEEIKELGSGTYGSVF-----HGKWRGCDVAIKRIKASCFD-------GRPSERERLIAD 470 ++++LGSG YG V HG + AIK IK S FD + +++ + Sbjct: 55 YFKVRKLGSGAYGEVLLCREKHGHG---EKAIKVIKKSQFDKMKYSITNKIECDDKIHEE 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 + E +L SL HPN++ + V D L VTEF G Sbjct: 112 IYNEISLLKSLDHPNIIKLFDVFEDKKYFYL--VTEFYEGG 150
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 41.6 bits (96), Expect = 0.002 Identities = 42/161 (26%), Positives = 67/161 (41%), Gaps = 17/161 (10%) Frame = +3 Query: 162 CDNDKDGKKFDENTDGDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKND-----D 326 C + K F + + +G +K+S E A++ G+ K + Sbjct: 2 CSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNS-------EDLAINPGMYVRKKEGKIGES 54 Query: 327 LEEIKELGSGTYGSVF-----HGKWRGCDVAIKRIKASCFD-------GRPSERERLIAD 470 ++++LGSG YG V HG + AIK IK S FD + +++ + Sbjct: 55 YFKVRKLGSGAYGEVLLCREKHGHG---EKAIKVIKKSQFDKMKYSITNKIECDDKIHEE 111 Query: 471 FWKEAQILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 + E +L SL HPN++ + V D L VTEF G Sbjct: 112 IYNEISLLKSLDHPNIIKLFDVFEDKKYFYL--VTEFYEGG 150
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V V+ + L V EF+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL 83
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/90 (28%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVF--HGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 ++ ++++++G GTYG V+ K G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V V+ + L V EF+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL 83
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V V+ + L V EF+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL 83
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V V+ + L V EF+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL 83
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 41.6 bits (96), Expect = 0.002 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 5/89 (5%) Frame = +3 Query: 345 LGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 +G+G +G V G+ R VAIK +K +E++R DF EA I+ H Sbjct: 634 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-----TEKQR--RDFLCEASIMGQFDH 686 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 PNVV GVV G + V E+M NG+ Sbjct: 687 PNVVHLEGVVTRGK--PVMIVIEYMENGA 713
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%) Frame = +3 Query: 330 EEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSL 503 +++++LG GTYG V+ K + G VA+K+I+ DG PS R E +L + Sbjct: 11 QKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLE-DDGVPSTALR-------EISLLKEV 62 Query: 504 HHPNVVSFYGVV 539 HPNVVS + V+ Sbjct: 63 PHPNVVSLFDVL 74
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 ++ ++++++G GTYG V+ K + G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V V+ + L V EF+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL 83
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 8/100 (8%) Frame = +3 Query: 261 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC--------DVAIKRI 416 + + P++AE S L D L K LGSG +G V+ G VA+K + Sbjct: 1941 VSTLPSQAEIES--LPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTL 1998 Query: 417 KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 536 K D SE F KEA ++S HP+++ GV Sbjct: 1999 KRGATDQEKSE-------FLKEAHLMSKFDHPHILKLLGV 2031
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 8/100 (8%) Frame = +3 Query: 261 IESTPAEAEALSKGLQTIKNDDLEEIKELGSGTYGSVFHGKWRGC--------DVAIKRI 416 + + P++AE S L D L K LGSG +G V+ G VA+K + Sbjct: 78 VSTLPSQAEIES--LPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTL 135 Query: 417 KASCFDGRPSERERLIADFWKEAQILSSLHHPNVVSFYGV 536 K D SE F KEA ++S HP+++ GV Sbjct: 136 KRGATDQEKSE-------FLKEAHLMSKFDHPHILKLLGV 168
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 41.6 bits (96), Expect = 0.002 Identities = 32/93 (34%), Positives = 46/93 (49%), Gaps = 5/93 (5%) Frame = +3 Query: 327 LEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 +EE+ +G+G +G V G+ R VAIK +K +ER+R DF EA I Sbjct: 625 IEEV--IGAGEFGEVCRGRLKLPGRREIFVAIKTLKVGY-----TERQR--RDFLSEASI 675 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVN 590 + HPN++ GVV + +TEFM N Sbjct: 676 MGQFDHPNIIHLEGVVT--KSRPVMIITEFMEN 706
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/91 (34%), Positives = 47/91 (51%), Gaps = 3/91 (3%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASC-FDGRPSERERLIADFWKEAQI 491 D ++++++G GTYG V+ K R G VA+K+I+ +G PS R E + Sbjct: 2 DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIR-------EISL 54 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L L HPN+V VV + + L V EF+ Sbjct: 55 LKELKHPNIVRLLDVVHN--ERKLYLVFEFL 83
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 41.6 bits (96), Expect = 0.002 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQIL 494 ++ ++++++G GTYG V+ + R G VA+K+I+ +E E + + +E +L Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLD------TETEGVPSTAIREISLL 55 Query: 495 SSLHHPNVVSFYGVVRDGPDGSLATVTEFM 584 L+HPN+V V+ + L V EF+ Sbjct: 56 KELNHPNIVKLLDVIH--TENKLYLVFEFL 83
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 41.6 bits (96), Expect = 0.002 Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 6/92 (6%) Frame = +3 Query: 339 KELGSGTYGSVFHGKWRGCD------VAIKRIKASCFDGRPSERERLIADFWKEAQILSS 500 K +G+G +G V+ G + VAIK +KA +E++R+ DF EA I+ Sbjct: 618 KVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGY-----TEKQRV--DFLSEASIMGQ 670 Query: 501 LHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 H N++ GVV + +TE+M NG+ Sbjct: 671 FSHHNIIPLEGVV--SKYKPMMIITEYMENGA 700
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 41.6 bits (96), Expect = 0.002 Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 2/88 (2%) Frame = +3 Query: 336 IKELGSGTYGSVFHGKWR--GCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHH 509 ++ +G G+YG V K R G IK++ S RER A+ +EAQ+LS L H Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLR----NASSRERRAAE--QEAQLLSQLKH 62 Query: 510 PNVVSFYGVVRDGPDGSLATVTEFMVNG 593 PN+V+ Y +G DG L V F G Sbjct: 63 PNIVT-YKESWEGGDGLLYIVMGFCEGG 89
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 41.2 bits (95), Expect = 0.002 Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 5/95 (5%) Frame = +3 Query: 324 DLEEIKELGSGTYGSVFHGKW-----RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQ 488 D+E ++ELG G +G V+ G+ VAIK +K + + DF +E + Sbjct: 409 DVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENA-------SVKTQQDFKREIE 461 Query: 489 ILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNG 593 ++S L H N+V GVV + + E+M NG Sbjct: 462 LISDLKHQNIVCILGVVLN--KEPYCMLFEYMANG 494
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 41.2 bits (95), Expect = 0.002 Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 5/122 (4%) Frame = +3 Query: 180 GKKFDENTD---GDQDPDVHGSCDQHKSSGIESTPAEAEALSKGLQTIKNDDLEEIKELG 350 GK +ENT D D++ SC + + T E + L D ++LG Sbjct: 23 GKNTNENTSKQSNDYKYDINTSCISREGT----TTLERKNLILCHSGKLEDKYIIDEKLG 78 Query: 351 SGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERL--IADFWKEAQILSSLHHPNVVS 524 GTYG V+ G I ++ + + +++RL I F++E +I+ L HPN+V Sbjct: 79 QGTYGCVYKG--------IDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVK 130 Query: 525 FY 530 Y Sbjct: 131 LY 132
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 41.2 bits (95), Expect = 0.002 Identities = 25/86 (29%), Positives = 47/86 (54%), Gaps = 2/86 (2%) Frame = +3 Query: 345 LGSGTYGSVFHGKW--RGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSSLHHPNV 518 +G G +G+V+ G G +A+K++ + + + I + +E ++L +L HPN+ Sbjct: 74 IGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 133 Query: 519 VSFYGVVRDGPDGSLATVTEFMVNGS 596 V + G VR+ D +L + EF+ GS Sbjct: 134 VRYLGTVRE--DETLNILLEFVPGGS 157
>NIMA_EMENI (P11837) G2-specific protein kinase nimA (EC 2.7.11.1) (Never in| mitosis) Length = 699 Score = 41.2 bits (95), Expect = 0.002 Identities = 23/70 (32%), Positives = 39/70 (55%) Frame = +3 Query: 321 DDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQILSS 500 D E ++++G G++G + K + + R + + ERE+L A+F ILSS Sbjct: 9 DKYEVLEKIGCGSFGIIRKVKRKSDGFILCRKEINYIKMSTKEREQLTAEF----NILSS 64 Query: 501 LHHPNVVSFY 530 L HPN+V++Y Sbjct: 65 LRHPNIVAYY 74
>DSOR1_DROME (Q24324) Dual specificity mitogen-activated protein kinase kinase| dSOR1 (EC 2.7.12.2) (Downstream of RAF) (MAPKK) Length = 396 Score = 41.2 bits (95), Expect = 0.002 Identities = 26/95 (27%), Positives = 51/95 (53%) Frame = +3 Query: 312 IKNDDLEEIKELGSGTYGSVFHGKWRGCDVAIKRIKASCFDGRPSERERLIADFWKEAQI 491 + ++DLE++ ELGSG G V + + + R K + +P+ +++++ +E ++ Sbjct: 82 LSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMAR-KLIHLEVKPAIKKQIL----RELKV 136 Query: 492 LSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGS 596 L + P++V FYG DG ++ E+M GS Sbjct: 137 LHECNFPHIVGFYGAFYS--DGEISICMEYMDGGS 169 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 81,453,405 Number of Sequences: 219361 Number of extensions: 1591673 Number of successful extensions: 7566 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6539 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7221 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5196311029 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
