ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal21i17 |
|---|---|
| Clone Library Name | barley_pub |
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 159 bits (402), Expect = 6e-39 Identities = 91/193 (47%), Positives = 124/193 (64%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK LE+ E F E++ IG I+H N+VR+ GFCSEG+ R L+ EY+ N SL + Sbjct: 559 VAVKKLENVRQGKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANIL 618 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 FS NI LL +IALG+A+G+ YLH C + ++H D+KP NILLD F PKI+ Sbjct: 619 FSEGGNI---LLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKIT 675 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGL KL R S ++ RGT+GYIAPE S ++ K DVYS+G+++LE+++G R Sbjct: 676 DFGLVKLLNRGGSTQNVSHVRGTLGYIAPEWVSSL--PITAKVDVYSYGVVLLELLTGTR 733 Query: 560 NSDPSVENQDEVY 598 S+ V DEV+ Sbjct: 734 VSE-LVGGTDEVH 745
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 154 bits (388), Expect = 2e-37 Identities = 84/188 (44%), Positives = 120/188 (63%), Gaps = 1/188 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L +G +AVK L ++ +G +EF+NEV I + H N+V+++G C EG + LIYEY+ N Sbjct: 547 LLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLEN 606 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL+ Y+F + L + DI G+ARG+ YLHQ RI+H D+K NILLD Sbjct: 607 LSLDSYLFGKTR---RSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDK 663 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 N PKISDFG+A++ RD++ GT GY++PE +G S KSDV+SFG++VL Sbjct: 664 NMIPKISDFGMARIFERDETEANTMKVVGTYGYMSPEY--AMYGIFSEKSDVFSFGVIVL 721 Query: 539 EMVSGRRN 562 E+VSG++N Sbjct: 722 EIVSGKKN 729
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 149 bits (375), Expect = 8e-36 Identities = 81/192 (42%), Positives = 122/192 (63%), Gaps = 1/192 (0%) Frame = +2 Query: 20 VAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKY 196 VA+K L+ + +G EF+ EV T+ L H N+V+L+GFC+EG +R L+YEYMP SLE + Sbjct: 129 VAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDH 188 Query: 197 IFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKI 376 + HV +K L + IA G ARG+EYLH +++ D+K NILL ++ PK+ Sbjct: 189 L--HVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKL 246 Query: 377 SDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 556 SDFGLAK+ T GT GY AP+ Y+ G +++KSD+YSFG+++LE+++GR Sbjct: 247 SDFGLAKVGPSGDKTHVSTRVMGTYGYCAPD-YAMT-GQLTFKSDIYSFGVVLLELITGR 304 Query: 557 RNSDPSVENQDE 592 + D + +D+ Sbjct: 305 KAIDNTKTRKDQ 316
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 146 bits (369), Expect = 4e-35 Identities = 81/197 (41%), Positives = 121/197 (61%), Gaps = 1/197 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 LR+G VA+K L TG+G+ EF+ E+ TIG I H N+V L+G+C G R L+YEYM Sbjct: 878 LRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKW 937 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SLE + S L IA+G ARG+ +LH C I+H D+K N+LLD Sbjct: 938 GSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDE 997 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 +F ++SDFG+A+L + + L+++ GT GY+ PE Y ++F + K DVYS+G+++L Sbjct: 998 DFEARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYY-QSF-RCTAKGDVYSYGVILL 1055 Query: 539 EMVSGRRNSDPSVENQD 589 E++SG++ DP +D Sbjct: 1056 ELLSGKKPIDPGEFGED 1072
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 144 bits (364), Expect = 1e-34 Identities = 81/195 (41%), Positives = 121/195 (62%), Gaps = 1/195 (0%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 G VAVK L+ + +G EF+ EV + L+HH N+V L+G+C++G +R L+YE+MP SL Sbjct: 109 GQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSL 168 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 E ++ H ++ L + IA G A+G+E+LH N +++ D K NILLD F+ Sbjct: 169 EDHL--HDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFH 226 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 PK+SDFGLAKL T GT GY APE Y+ G ++ KSDVYSFG++ LE++ Sbjct: 227 PKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPE-YAMT-GQLTVKSDVYSFGVVFLELI 284 Query: 548 SGRRNSDPSVENQDE 592 +GR+ D + + ++ Sbjct: 285 TGRKAIDSEMPHGEQ 299
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 141 bits (356), Expect = 1e-33 Identities = 80/191 (41%), Positives = 122/191 (63%), Gaps = 1/191 (0%) Frame = +2 Query: 20 VAVKML-ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKY 196 VAVK L E+ T EF+ E+ T+G + H N+V L+G+CS + L+YEYM N SL+ + Sbjct: 942 VAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHW 1001 Query: 197 IFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKI 376 + + + ++L +K L IA+G ARG+ +LH G I+H DIK NILLD +F PK+ Sbjct: 1002 LRNQTGML--EVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKV 1059 Query: 377 SDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 556 +DFGLA+L + +S ++ T GT GYI PE Y ++ + K DVYSFG+++LE+V+G+ Sbjct: 1060 ADFGLARLISACESHVS-TVIAGTFGYIPPE-YGQS-ARATTKGDVYSFGVILLELVTGK 1116 Query: 557 RNSDPSVENQD 589 + P + + Sbjct: 1117 EPTGPDFKESE 1127
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 141 bits (355), Expect = 2e-33 Identities = 79/190 (41%), Positives = 120/190 (63%), Gaps = 1/190 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L++G VA+K L +G+G+ EF E+ TIG I H N+V L+G+C G R L+YEYM Sbjct: 907 LKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKY 966 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SLE + I KL P + IA+G ARG+ +LH C I+H D+K N+LLD Sbjct: 967 GSLEDVLHDR-KKIGIKLNWPARR-KIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDE 1024 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 N ++SDFG+A+L + + L+++ GT GY+ PE Y ++F S K DVYS+G+++L Sbjct: 1025 NLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY-QSF-RCSTKGDVYSYGVVLL 1082 Query: 539 EMVSGRRNSD 568 E+++G++ +D Sbjct: 1083 ELLTGKQPTD 1092
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 140 bits (354), Expect = 2e-33 Identities = 79/197 (40%), Positives = 120/197 (60%), Gaps = 1/197 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L +G VA+K L TG+G+ EF+ E+ TIG I H N+V L+G+C G R L+YEYM Sbjct: 877 LADGSVVAIKKLIQVTGQGDREFMAEMETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKY 936 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SLE + L + IA+G ARG+ +LH C I+H D+K N+LLD Sbjct: 937 GSLETVLHEKTKK-GGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQ 995 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 +F ++SDFG+A+L + + L+++ GT GY+ PE Y ++F + K DVYS+G+++L Sbjct: 996 DFVARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYY-QSF-RCTAKGDVYSYGVILL 1053 Query: 539 EMVSGRRNSDPSVENQD 589 E++SG++ DP +D Sbjct: 1054 ELLSGKKPIDPEEFGED 1070
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 140 bits (353), Expect = 3e-33 Identities = 78/190 (41%), Positives = 121/190 (63%), Gaps = 1/190 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L++G VA+K L +G+G+ EF+ E+ TIG I H N+V L+G+C G R L+YE+M Sbjct: 902 LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKY 961 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SLE + KL T+ IA+G ARG+ +LH C+ I+H D+K N+LLD Sbjct: 962 GSLED-VLHDPKKAGVKLNWSTRR-KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDE 1019 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 N ++SDFG+A+L + + L+++ GT GY+ PE Y ++F S K DVYS+G+++L Sbjct: 1020 NLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY-QSF-RCSTKGDVYSYGVVLL 1077 Query: 539 EMVSGRRNSD 568 E+++G+R +D Sbjct: 1078 ELLTGKRPTD 1087
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 139 bits (350), Expect = 6e-33 Identities = 78/190 (41%), Positives = 119/190 (62%), Gaps = 1/190 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L++G VA+K L +G+G+ EF E+ TIG I H N+V L+G+C G R L+YEYM Sbjct: 907 LKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKY 966 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SLE + KL P + IA+G ARG+ +LH C I+H D+K N+LLD Sbjct: 967 GSLEDVLHDR-KKTGIKLNWPARR-KIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDE 1024 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 N ++SDFG+A+L + + L+++ GT GY+ PE Y ++F S K DVYS+G+++L Sbjct: 1025 NLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY-QSF-RCSTKGDVYSYGVVLL 1082 Query: 539 EMVSGRRNSD 568 E+++G++ +D Sbjct: 1083 ELLTGKQPTD 1092
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 138 bits (348), Expect = 1e-32 Identities = 75/194 (38%), Positives = 119/194 (61%), Gaps = 3/194 (1%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE---EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYM 172 L +G +AVK +E+ G+ EF +E+A + + H ++V L+G+C +G + L+YEYM Sbjct: 607 LHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYM 666 Query: 173 PNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 352 P +L +++F S K L + L +AL +ARG+EYLH +Q +H D+KP NILL Sbjct: 667 PQGTLSRHLFEW-SEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILL 725 Query: 353 DYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGML 532 + K++DFGL +L + + T GT GY+APE G V+ K DVYSFG++ Sbjct: 726 GDDMRAKVADFGLVRLAPEGKGSIE-TRIAGTFGYLAPEYAVT--GRVTTKVDVYSFGVI 782 Query: 533 VLEMVSGRRNSDPS 574 ++E+++GR++ D S Sbjct: 783 LMELITGRKSLDES 796
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 138 bits (347), Expect = 1e-32 Identities = 84/190 (44%), Positives = 114/190 (60%), Gaps = 1/190 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L +G VA+K L G+ E EF EV T+ H N+V L GFC R LIY YM N Sbjct: 753 LPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMEN 812 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL+ ++ H N LL L IA G A+G+ YLH+GC+ ILH DIK NILLD Sbjct: 813 GSLDYWL--HERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDE 870 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 NFN ++DFGLA+L + ++ ++ T GT+GYI PE + +YK DVYSFG+++L Sbjct: 871 NFNSHLADFGLARLMSPYETHVS-TDLVGTLGYIPPEYGQASV--ATYKGDVYSFGVVLL 927 Query: 539 EMVSGRRNSD 568 E+++ +R D Sbjct: 928 ELLTDKRPVD 937
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 136 bits (343), Expect = 4e-32 Identities = 86/201 (42%), Positives = 117/201 (58%), Gaps = 3/201 (1%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGEE--FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMP 175 L +G VAVK L+ +G E F EV I + H N++RL GFC T R L+Y YM Sbjct: 308 LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMA 367 Query: 176 NESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLD 355 N S+ + SQ L K IALG ARG+ YLH C+ +I+H D+K NILLD Sbjct: 368 NGSVASCLRERPE--SQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLD 425 Query: 356 YNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLV 535 F + DFGLAKL + +T TA RGT+G+IAPE S G S K+DV+ +G+++ Sbjct: 426 EEFEAVVGDFGLAKLMDYKDTHVT-TAVRGTIGHIAPEYLST--GKSSEKTDVFGYGVML 482 Query: 536 LEMVSGRRNSD-PSVENQDEV 595 LE+++G+R D + N D+V Sbjct: 483 LELITGQRAFDLARLANDDDV 503
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 135 bits (341), Expect = 7e-32 Identities = 76/184 (41%), Positives = 114/184 (61%), Gaps = 1/184 (0%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 NG VAVK+L + +G +EF EV + +HH N+ L+G+C+E LIYEYM NE+ Sbjct: 594 NGEQVAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANEN 653 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L Y+ S I L+ + L I+L A+G+EYLH GC I+H D+KP NILL+ Sbjct: 654 LGDYLAGKRSFI----LSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKL 709 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K++DFGL++ + + S T G++GY+ PE YS ++ KSDVYS G+++LE+ Sbjct: 710 QAKMADFGLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTR--QMNEKSDVYSLGVVLLEV 767 Query: 545 VSGR 556 ++G+ Sbjct: 768 ITGQ 771
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 134 bits (336), Expect = 3e-31 Identities = 72/190 (37%), Positives = 120/190 (63%), Gaps = 1/190 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L++G VA+K L + +G+ EF+ E+ T+G I H N+V L+G+C G R L+YE+M Sbjct: 857 LKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQY 916 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SLE+ + + +++L + IA G A+G+ +LH C I+H D+K N+LLD Sbjct: 917 GSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQ 976 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 + ++SDFG+A+L + + L+++ GT GY+ PE Y ++F + K DVYS G+++L Sbjct: 977 DMEARVSDFGMARLISALDTHLSVSTLAGTPGYVPPEYY-QSF-RCTAKGDVYSIGVVML 1034 Query: 539 EMVSGRRNSD 568 E++SG+R +D Sbjct: 1035 EILSGKRPTD 1044
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 132 bits (333), Expect = 6e-31 Identities = 78/187 (41%), Positives = 111/187 (59%), Gaps = 1/187 (0%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 GV +AVK L +G +E++ EV +G H N+V+L+G+C E R L+YE+MP SL Sbjct: 101 GVVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSL 160 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 E ++F S L+ T L +ALG A+G+ +LH +++ D K NILLD +N Sbjct: 161 ENHLFRRGSYFQP--LSWTLRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILLDSEYN 217 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K+SDFGLAK T GT GY APE + G ++ KSDVYS+G+++LE++ Sbjct: 218 AKLSDFGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLAT--GHLTTKSDVYSYGVVLLEVL 275 Query: 548 SGRRNSD 568 SGRR D Sbjct: 276 SGRRAVD 282
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 132 bits (332), Expect = 8e-31 Identities = 75/186 (40%), Positives = 112/186 (60%), Gaps = 1/186 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L +G VAVK+ S++ +G EF NE+ + I H N+V L+G+C+E ++ L+Y +M N Sbjct: 615 LDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSN 674 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL ++ S +K+L L IALG ARG+ YLH + ++H D+K NILLD Sbjct: 675 GSLLDRLYGEASK--RKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQ 732 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 + K++DFG +K ++ RGT GY+ PE Y +S KSDV+SFG+++L Sbjct: 733 SMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQ--QLSEKSDVFSFGVVLL 790 Query: 539 EMVSGR 556 E+VSGR Sbjct: 791 EIVSGR 796
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 132 bits (331), Expect = 1e-30 Identities = 82/210 (39%), Positives = 121/210 (57%), Gaps = 14/210 (6%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGEE-----------FINEVATIGLIHHANIVRLMGFCSEGTR 148 LR G VAVK L S G++ F EV T+G I H +IVRL CS G Sbjct: 702 LRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHKSIVRLWCCCSSGDC 761 Query: 149 RALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFD 328 + L+YEYMPN SL + H +L + L IAL A G+ YLH C I+H D Sbjct: 762 KLLVYEYMPNGSLADVL--HGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRD 819 Query: 329 IKPHNILLDYNFNPKISDFGLAKL--CARDQSILTLTAARGTMGYIAPE-LYSRNFGGVS 499 +K NILLD ++ K++DFG+AK+ + ++ ++ G+ GYIAPE +Y+ V+ Sbjct: 820 VKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYVYTLR---VN 876 Query: 500 YKSDVYSFGMLVLEMVSGRRNSDPSVENQD 589 KSD+YSFG+++LE+V+G++ +D + ++D Sbjct: 877 EKSDIYSFGVVLLELVTGKQPTDSELGDKD 906
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 130 bits (328), Expect = 2e-30 Identities = 77/187 (41%), Positives = 113/187 (60%), Gaps = 1/187 (0%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 G+ +AVK L +G E++ E+ +G + H N+V+L+G+C E R L+YE+M SL Sbjct: 100 GIVIAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSL 159 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 E ++F Q L T+ + +ALG ARG+ +LH ++++ D K NILLD N+N Sbjct: 160 ENHLFRR-GTFYQPLSWNTR-VRMALGAARGLAFLH-NAQPQVIYRDFKASNILLDSNYN 216 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K+SDFGLA+ + T GT GY APE + G +S KSDVYSFG+++LE++ Sbjct: 217 AKLSDFGLARDGPMGDNSHVSTRVMGTQGYAAPEYLAT--GHLSVKSDVYSFGVVLLELL 274 Query: 548 SGRRNSD 568 SGRR D Sbjct: 275 SGRRAID 281
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 130 bits (328), Expect = 2e-30 Identities = 73/196 (37%), Positives = 120/196 (61%), Gaps = 3/196 (1%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTG---EGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYM 172 LR+G VAVK ++ +EF NE+ + ++HA+++ L+G+C +G+ R L+YE+M Sbjct: 524 LRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFM 583 Query: 173 PNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 352 + SL +++ N+ +K L + + IA+ ARG+EYLH ++H DIK NIL+ Sbjct: 584 AHGSLYQHLHGKDPNL-KKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI 642 Query: 353 DYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGML 532 D + N +++DFGL+ L D GT+GY+ PE Y ++ ++ KSDVYSFG++ Sbjct: 643 DEDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHY--LTTKSDVYSFGVV 700 Query: 533 VLEMVSGRRNSDPSVE 580 +LE++SGR+ D E Sbjct: 701 LLEILSGRKAIDMQFE 716
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 130 bits (327), Expect = 3e-30 Identities = 73/186 (39%), Positives = 113/186 (60%), Gaps = 1/186 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L +G VAVK+ +++ +G EF NE+ + I H N+V L+G+C+E ++ L+Y +M N Sbjct: 614 LDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSN 673 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL ++ + +K+L L IALG ARG+ YLH + ++H D+K NILLD+ Sbjct: 674 GSLLDRLYGEPAK--RKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDH 731 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 + K++DFG +K ++ RGT GY+ PE Y +S KSDV+SFG+++L Sbjct: 732 SMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQ--QLSEKSDVFSFGVVLL 789 Query: 539 EMVSGR 556 E+VSGR Sbjct: 790 EIVSGR 795
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 130 bits (327), Expect = 3e-30 Identities = 80/190 (42%), Positives = 108/190 (56%), Gaps = 1/190 (0%) Frame = +2 Query: 2 LRNGVPVAVKMLESSTGEGE-EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 L +G VA+K L TG+ + EF EV T+ H N+V L+G+C+ + LIY YM N Sbjct: 762 LPDGTKVAIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDN 821 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL+ ++ V L L IA G A G+ YLHQ C ILH DIK NILL Sbjct: 822 GSLDYWLHEKVDGPPS--LDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSD 879 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 F ++DFGLA+L + +T T GT+GYI PE + +YK DVYSFG+++L Sbjct: 880 TFVAHLADFGLARLILPYDTHVT-TDLVGTLGYIPPEYGQASV--ATYKGDVYSFGVVLL 936 Query: 539 EMVSGRRNSD 568 E+++GRR D Sbjct: 937 ELLTGRRPMD 946
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 130 bits (326), Expect = 4e-30 Identities = 78/190 (41%), Positives = 113/190 (59%), Gaps = 4/190 (2%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 G+ +AVK L +G +E++ EV +G H ++V+L+G+C E R L+YE+MP SL Sbjct: 100 GLVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSL 159 Query: 188 EKYIFS---HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 E ++F + +S KL L +ALG A+G+ +LH R+++ D K NILLD Sbjct: 160 ENHLFRRGLYFQPLSWKL-----RLKVALGAAKGLAFLHSS-ETRVIYRDFKTSNILLDS 213 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 +N K+SDFGLAK T GT GY APE + G ++ KSDVYSFG+++L Sbjct: 214 EYNAKLSDFGLAKDGPIGDKSHVSTRVMGTHGYAAPEYLAT--GHLTTKSDVYSFGVVLL 271 Query: 539 EMVSGRRNSD 568 E++SGRR D Sbjct: 272 ELLSGRRAVD 281
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 127 bits (318), Expect = 3e-29 Identities = 71/183 (38%), Positives = 111/183 (60%), Gaps = 1/183 (0%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 +G+ VA+K L S + +G E+ +EV +G++ H N+V+L+G+C E L+YE+MP S Sbjct: 117 SGMIVAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGS 176 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 LE ++F L + I +G ARG+ +LH + +++ D K NILLD N+ Sbjct: 177 LESHLFRRNDPFPWDL-----RIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLDSNY 230 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 + K+SDFGLAKL D+ T GT GY APE + G + KSDV++FG+++LE+ Sbjct: 231 DAKLSDFGLAKLGPADEKSHVTTRIMGTYGYAAPEYMAT--GHLYVKSDVFAFGVVLLEI 288 Query: 545 VSG 553 ++G Sbjct: 289 MTG 291
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 120 bits (302), Expect = 2e-27 Identities = 73/186 (39%), Positives = 108/186 (58%), Gaps = 2/186 (1%) Frame = +2 Query: 8 NGVPVAVKMLES-STGEGEE-FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 N V VA+K L TG + F E+ T+G I H +IVRL+G+ + L+YEYMPN Sbjct: 713 NNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVANKDTNLLLYEYMPNG 772 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL + + Q +A+ A+G+ YLH C+ ILH D+K +NILLD + Sbjct: 773 SLGELLHGSKGGHLQWETRHR----VAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSD 828 Query: 362 FNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLE 541 F ++DFGLAK + +++ G+ GYIAPE Y+ V KSDVYSFG+++LE Sbjct: 829 FEAHVADFGLAKFLVDGAASECMSSIAGSYGYIAPE-YAYTL-KVDEKSDVYSFGVVLLE 886 Query: 542 MVSGRR 559 +++G++ Sbjct: 887 LIAGKK 892
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 119 bits (298), Expect = 7e-27 Identities = 68/177 (38%), Positives = 106/177 (59%), Gaps = 1/177 (0%) Frame = +2 Query: 68 INEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTK 247 + E+ TIG + H N+++L F ++Y YM N SL + H +N + L T+ Sbjct: 859 VREIETIGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDIL--HETNPPKPLDWSTR 916 Query: 248 MLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILT 427 +IA+G A G+ YLH C+ I+H DIKP NILLD + P ISDFG+AKL + + + Sbjct: 917 H-NIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSATSIP 975 Query: 428 LTAARGTMGYIAPELYSRNFGGV-SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 595 +GT+GY+APE F V S +SDVYS+G+++LE+++ ++ DPS + ++ Sbjct: 976 SNTVQGTIGYMAPE---NAFTTVKSRESDVYSYGVVLLELITRKKALDPSFNGETDI 1029
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 109 bits (273), Expect = 5e-24 Identities = 65/179 (36%), Positives = 100/179 (55%), Gaps = 1/179 (0%) Frame = +2 Query: 53 EGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKL 232 E ++ NE+ + I H NI+ L G+ +G + L+Y+ M SLE + +H + Sbjct: 255 ELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPA 314 Query: 233 LAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARD 412 L + I+LG ARG+ +LH ++H DIKP NILLD PKI DFGL + + Sbjct: 315 LTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKS 374 Query: 413 -QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQ 586 +++ + GT Y+ PE RNF +S DVYSFG+++LE+ +GR+ +D EN+ Sbjct: 375 LDAVVEVNKVFGTKIYLPPEF--RNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENE 431
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 109 bits (272), Expect = 7e-24 Identities = 75/199 (37%), Positives = 108/199 (54%), Gaps = 6/199 (3%) Frame = +2 Query: 8 NGVPVAVK----MLESSTGE-GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYM 172 N VAVK M+E ST E ++F E+ + H N+V L+GF S+ L+Y YM Sbjct: 206 NNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYM 265 Query: 173 PNESLEKYIFSHVSNIS-QKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 349 PN SL +S + L+ +A G A G+ +LH+ + +H DIK NIL Sbjct: 266 PNGSL----LDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANIL 318 Query: 350 LDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGM 529 LD +F KISDFGLA+ AR + + GT Y+APE G ++ KSD+YSFG+ Sbjct: 319 LDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEALR---GEITPKSDIYSFGV 375 Query: 530 LVLEMVSGRRNSDPSVENQ 586 ++LE+++G D + E Q Sbjct: 376 VLLELITGLAAVDENREPQ 394
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 107 bits (267), Expect = 3e-23 Identities = 60/174 (34%), Positives = 100/174 (57%), Gaps = 7/174 (4%) Frame = +2 Query: 59 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 + F+ EV + H NIV G+C+E L+Y ++PN SLE + H+ + L+ Sbjct: 254 QSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQL--HLQTQACSPLS 311 Query: 239 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKL------ 400 + LDI LG AR +++LHQ + ++H DIK N+LLD PK+ DFGLA+ Sbjct: 312 WPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGA 370 Query: 401 -CARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 ++ ++ + RGT+ Y+ PE Y + G ++ +D +SFG+++LE ++G+R Sbjct: 371 KASQSSTVARTSTVRGTLAYL-PEEYIKT-GRLAVDTDTFSFGVVILETLAGQR 422
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 105 bits (262), Expect = 1e-22 Identities = 65/197 (32%), Positives = 107/197 (54%), Gaps = 11/197 (5%) Frame = +2 Query: 2 LRNGVPVAVKMLESS----TGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEY 169 +RN V ++ E++ T + F+ EV + H NIV G+C++ L+Y + Sbjct: 231 MRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGF 290 Query: 170 MPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 349 +PN SLE + H + L+ + LDI LG AR +++LHQ + ++H DIK N+L Sbjct: 291 LPNGSLEDRL--HCQTQACPPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVL 347 Query: 350 LDYNFNPKISDFGLAKLC-------ARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKS 508 LD PK+ DFGLA+ ++ + RGT+ Y+ PE Y + G ++ + Sbjct: 348 LDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PEEYIKT-GRLAVDT 405 Query: 509 DVYSFGMLVLEMVSGRR 559 D +SFG++VLE ++G+R Sbjct: 406 DTFSFGVVVLETLAGQR 422
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 103 bits (257), Expect = 4e-22 Identities = 73/199 (36%), Positives = 106/199 (53%), Gaps = 6/199 (3%) Frame = +2 Query: 8 NGVPVAVK----MLESSTGE-GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYM 172 N VAVK M++ +T E ++F E+ + H N+V L+GF S+G L+Y YM Sbjct: 206 NNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYM 265 Query: 173 PNESLEKYIFSHVSNIS-QKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 349 PN SL +S + L+ IA G A G+ +LH+ + +H DIK NIL Sbjct: 266 PNGSL----LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANIL 318 Query: 350 LDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGM 529 LD F KISDFGLA+ + + + GT Y+APE G ++ KSD+YSFG+ Sbjct: 319 LDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR---GEITPKSDIYSFGV 375 Query: 530 LVLEMVSGRRNSDPSVENQ 586 ++LE+++G D E Q Sbjct: 376 VLLEIITGLPAVDEHREPQ 394
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 101 bits (251), Expect = 2e-21 Identities = 63/177 (35%), Positives = 99/177 (55%), Gaps = 15/177 (8%) Frame = +2 Query: 65 FINEVATIGLIHHANIVRLMGFCSEG--TRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 F NEV + + H N+V+ +G C+ G ++ E+M SL +++ H + + Q Sbjct: 1332 FQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQN--- 1388 Query: 239 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP-------------KIS 379 P L +AL IA+GM YLH G ILH D+ NILLD+N +P KIS Sbjct: 1389 PHIRLKLALDIAKGMNYLH-GWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKIS 1447 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++L + + +T + G + Y+APE++ + S KSDVYS+GM++ E+++ Sbjct: 1448 DFGLSRL--KKEQASQMTQSVGCIPYMAPEVFKGDSN--SEKSDVYSYGMVLFELLT 1500
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 95.5 bits (236), Expect = 1e-19 Identities = 65/189 (34%), Positives = 108/189 (57%), Gaps = 3/189 (1%) Frame = +2 Query: 2 LRNGVPVAVKMLESST-GEGEEFINEVATIGLIHHANIVRLMGFCSEGTR--RALIYEYM 172 L +G +A+++L T + + + +G I H N+V L F +G R + LIY+Y+ Sbjct: 392 LSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFY-QGKRGEKLLIYDYL 450 Query: 173 PNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL 352 PN SL + H S + L + IALGIARG+ YLH G I+H +I+ N+L+ Sbjct: 451 PNISLHDLL--HESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLV 508 Query: 353 DYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGML 532 D F ++++FGL K+ + + ++ A+ GY APEL+ + +SDVY+FG+L Sbjct: 509 DDFFFARLTEFGLDKIMVQAVADEIVSQAKSD-GYKAPELHKMK--KCNPRSDVYAFGIL 565 Query: 533 VLEMVSGRR 559 +LE++ G++ Sbjct: 566 LLEILMGKK 574
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 94.4 bits (233), Expect = 2e-19 Identities = 65/184 (35%), Positives = 102/184 (55%), Gaps = 3/184 (1%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGE---EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 +G VAVK+L E EF+ EVA + + H NIV MG ++ +++ EY+ Sbjct: 571 HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSR 630 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL Y H S ++L + L +A +A+GM YLH N I+H D+K N+L+D Sbjct: 631 GSL--YRLLHKSGAREQL-DERRRLSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDK 686 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 + K+ DFGL++L A + L+ +A GT ++APE+ + KSDVYSFG+++ Sbjct: 687 KYTVKVCDFGLSRLKA--STFLSSKSAAGTPEWMAPEVLRDE--PSNEKSDVYSFGVILW 742 Query: 539 EMVS 550 E+ + Sbjct: 743 ELAT 746
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 91.7 bits (226), Expect = 1e-18 Identities = 58/182 (31%), Positives = 106/182 (58%), Gaps = 3/182 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K+L +TG EF++E + + H ++VRL+G C T + L+ + MP+ L Sbjct: 746 IPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCL 804 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 +Y+ H NI +LL L+ + IA+GM YL + +R++H D+ N+L+ + Sbjct: 805 LEYVHEHKDNIGSQLL-----LNWCVQIAKGMMYLEE---RRLVHRDLAARNVLVKSPNH 856 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEM 544 KI+DFGLA+L D+ + + ++A E ++ R F +++SDV+S+G+ + E+ Sbjct: 857 VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF---THQSDVWSYGVTIWEL 913 Query: 545 VS 550 ++ Sbjct: 914 MT 915
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 90.9 bits (224), Expect = 3e-18 Identities = 58/182 (31%), Positives = 106/182 (58%), Gaps = 3/182 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K+L +TG EF++E + + H ++VRL+G C T + L+ + MP+ L Sbjct: 746 IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCL 804 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 +Y+ H NI +LL L+ + IA+GM YL + +R++H D+ N+L+ + Sbjct: 805 LEYVHEHKDNIGSQLL-----LNWCVQIAKGMMYLEE---RRLVHRDLAARNVLVKSPNH 856 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEM 544 KI+DFGLA+L D+ + + ++A E ++ R F +++SDV+S+G+ + E+ Sbjct: 857 VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF---THQSDVWSYGVTIWEL 913 Query: 545 VS 550 ++ Sbjct: 914 MT 915
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 90.5 bits (223), Expect = 3e-18 Identities = 63/194 (32%), Positives = 106/194 (54%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N PVA+K L+S T + ++F+ E + + H +++L C+ +I E M + SL Sbjct: 269 NTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSL 328 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 +Y+ + ++ + L T ++D+A IA GM YL +Q +H D+ N+L+ Sbjct: 329 LEYLQA-IAGKGRSLKMQT-LIDMAAQIAAGMAYLE---SQNYIHRDLAARNVLVGDGNI 383 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLA+L D+ + AR + + APE + N+ S KSDV+SFG+L+ E+V Sbjct: 384 VKIADFGLARLIKEDEYEARV-GARFPIKWTAPE--AANYSKFSIKSDVWSFGILLTELV 440 Query: 548 SGRRNSDPSVENQD 589 + R P + N + Sbjct: 441 TYGRIPYPGMTNAE 454
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 89.7 bits (221), Expect = 6e-18 Identities = 62/182 (34%), Positives = 98/182 (53%), Gaps = 4/182 (2%) Frame = +2 Query: 17 PVAVKMLESST---GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 PVAVK L T + + F NEVA + H NI+ MG C A++ ++ SL Sbjct: 451 PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSL 509 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 K++ HVS KL ++DI +A+GM+YLH + I+H D+K +NI L + + Sbjct: 510 YKHV--HVSETKFKL---NTLIDIGRQVAQGMDYLHA---KNIIHRDLKSNNIFLHEDLS 561 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEM 544 KI DFGLA R G++ ++APE + + S++SDVY+FG+++ E+ Sbjct: 562 VKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYEL 621 Query: 545 VS 550 ++ Sbjct: 622 LA 623
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 89.7 bits (221), Expect = 6e-18 Identities = 56/177 (31%), Positives = 92/177 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K ++ E+FI E + + H +V+L G C E L++E+M + L Y+ Sbjct: 393 VAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYL 452 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S + L A +L + L + GM YL + C ++H D+ N L+ N K+S Sbjct: 453 RS-----QRGLFAAETLLGMCLDVCEGMAYLEKAC---VIHRDLAARNCLVGENQVIKVS 504 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFG+ + DQ + T + + + +PE++S F S KSDV+SFG+L+ E+ S Sbjct: 505 DFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVFS--FSRYSSKSDVWSFGVLMWEVFS 558
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 88.6 bits (218), Expect = 1e-17 Identities = 55/177 (31%), Positives = 90/177 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K + E+FI E + + H +V+L G C E L++E+M + L Y+ Sbjct: 388 VAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYL 447 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + L A +L + L + GM YL + C ++H D+ N L+ N K+S Sbjct: 448 -----RTQRGLFAAETLLGMCLDVCEGMAYLEEAC---VIHRDLAARNCLVGENQVIKVS 499 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFG+ + DQ + T + + + +PE++S F S KSDV+SFG+L+ E+ S Sbjct: 500 DFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVFS--FSRYSSKSDVWSFGVLMWEVFS 553
>LET23_CAEEL (P24348) Receptor tyrosine-protein kinase let-23 precursor (EC| 2.7.10.1) (Lethal protein 23) Length = 1367 Score = 88.2 bits (217), Expect = 2e-17 Identities = 45/179 (25%), Positives = 101/179 (56%) Frame = +2 Query: 14 VPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 +PVA+K+ ++ + +E + E + + H N+++++GFC ++ Y P +L+ Sbjct: 958 IPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQN 1017 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ H N+ + + + IA GM+YL + QR++H D+ N+L+ + + Sbjct: 1018 FLKLHKENLGAR-----EQVLYCYQIASGMQYLEK---QRVVHRDLATRNVLVKKFNHVE 1069 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 I+DFGL+K+ D +T+ + + + ++A E++S++ ++ SDV++FG+ E+++ Sbjct: 1070 ITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC--YTHASDVWAFGVTCWEIIT 1126
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 88.2 bits (217), Expect = 2e-17 Identities = 67/187 (35%), Positives = 103/187 (55%), Gaps = 5/187 (2%) Frame = +2 Query: 11 GVPVAVK-MLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 GV VAVK ++ E + EF E+A + + H+NIV +G C + ++ EYM Sbjct: 1385 GVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMG 1444 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 +L + N K+ K L + G A G++YLH N I+H DIKP NIL+D + Sbjct: 1445 NLRDVL----KNPDIKITFANK-LKLLYGAAMGIDYLHSS-NPMIVHRDIKPANILVDEH 1498 Query: 362 FNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSY--KSDVYSFGMLV 535 FN KI+DFG A++ D + +T GT + APE+ G Y K+DV+SFG+++ Sbjct: 1499 FNVKIADFGFARI-KEDNTTMTRC---GTPCWTAPEV----IRGEKYCEKADVFSFGVVM 1550 Query: 536 LEMVSGR 556 E+++G+ Sbjct: 1551 WEVLTGK 1557 Score = 76.6 bits (187), Expect = 5e-14 Identities = 54/183 (29%), Positives = 92/183 (50%), Gaps = 3/183 (1%) Frame = +2 Query: 11 GVPVAVKMLES---STGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 G VAVK++ S S F EV + + H N+V M ++ ++ E+M Sbjct: 807 GTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLG 866 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL + + N + + +A ++GM +LH + I+H D+K N+LLD Sbjct: 867 SL----YDLLGNELIPEIPYALKIKMAYQASKGMHFLH---SSGIVHRDLKSLNLLLDSK 919 Query: 362 FNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLE 541 +N K+SDFGL K+ + T GT+ +IAPE+ + + +DVYSFG+++ E Sbjct: 920 WNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVYSFGIILWE 979 Query: 542 MVS 550 +++ Sbjct: 980 LLT 982
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 88.2 bits (217), Expect = 2e-17 Identities = 62/194 (31%), Positives = 97/194 (50%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N PVAVK L++ T + F+ E + + H +++L C++G +I E M SL Sbjct: 116 NSTPVAVKTLKAGTMQPAAFLAEAQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGSL 175 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 Y+ L +++D+A +A GM YL +H D+ NIL+ N Sbjct: 176 LDYLQGEAG-----ALKLPQLIDMAAQVAAGMAYLEL---HNYIHRDLAARNILVGDNNI 227 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K++DFGLA+L D T A+ + + APE + F S KSDV+SFG+L+ E+V Sbjct: 228 CKVADFGLARLIVSDDYNAT-EGAKFPIKWTAPE--AALFNRFSIKSDVWSFGILITELV 284 Query: 548 SGRRNSDPSVENQD 589 + R P + N + Sbjct: 285 TYGRIPYPGMSNAE 298
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 87.8 bits (216), Expect = 2e-17 Identities = 58/197 (29%), Positives = 106/197 (53%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VPVA+K L++ E + +F++E + +G H NI+RL G + G ++ EYM N SL Sbjct: 662 VPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSL 721 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ +H + +++ + G+ GM YL + +H D+ N+L+D N Sbjct: 722 DTFLRTHDGQFT-----IMQLVGMLRGVGAGMRYL---SDLGYVHRDLAARNVLVDSNLV 773 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D + T T + + + APE + F S SDV+SFG+++ E+ Sbjct: 774 CKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA--FRTFSSASDVWSFGVVMWEV 831 Query: 545 VSGRRNSDPSVENQDEV 595 ++ ++ N+D + Sbjct: 832 LAYGERPYWNMTNRDVI 848
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 87.4 bits (215), Expect = 3e-17 Identities = 70/216 (32%), Positives = 109/216 (50%), Gaps = 19/216 (8%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N VAVK L+ T + F+ E + + H +VRL + +I EYM SL Sbjct: 267 NSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 326 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ S+ K+L P K++D + IA GM Y+ + + +H D++ N+L+ + Sbjct: 327 LDFL---KSDEGGKVLLP-KLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLM 379 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLA++ D A+ + + APE + NFG + KSDV+SFG+L+ E+V Sbjct: 380 CKIADFGLARV-IEDNEYTAREGAKFPIKWTAPE--AINFGCFTIKSDVWSFGILLYEIV 436 Query: 548 S-------GRRNSD-----------PSVEN-QDEVY 598 + GR N+D P VEN DE+Y Sbjct: 437 TYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELY 472
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 87.4 bits (215), Expect = 3e-17 Identities = 67/195 (34%), Positives = 96/195 (49%), Gaps = 5/195 (2%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRR--ALIYEYMPNE 181 G VAVK L+ ST E +F E+ + + H NIV+ G C RR LI EY+P Sbjct: 876 GEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYG 935 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL Y+ H I K K+L I +GMEYL +R +H D+ NIL++ Sbjct: 936 SLRDYLQKHKERIDHK-----KLLQYTSQICKGMEYLG---TKRYIHRDLATRNILVENE 987 Query: 362 FNPKISDFGLAKLCARDQSILTL-TAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 KI DFGL K+ +D+ + + + APE S S SDV+SFG+++ Sbjct: 988 NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE--SLTESKFSVASDVWSFGVVLY 1045 Query: 539 EMVSG-RRNSDPSVE 580 E+ + ++ P VE Sbjct: 1046 ELFTYIEKSKSPPVE 1060
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 87.4 bits (215), Expect = 3e-17 Identities = 65/198 (32%), Positives = 104/198 (52%), Gaps = 2/198 (1%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N VAVK L+ T F++E + + H ++V+L CS+ ++ EYM SL Sbjct: 261 NTTQVAVKTLKPGTMSPASFLDEAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSL 320 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 Y+ S ++ +L PT ++D+A +A GM +L Q +H D+ NIL+ N+ Sbjct: 321 LDYL-SKGEGVNLQL--PT-LIDMAAQVASGMAFLEA---QGYIHRDLAARNILVGENYI 373 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPE--LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+L D A+ + + APE LY+R + KSDV+SFG+L+ E Sbjct: 374 CKVADFGLARL-IEDDEYTAHEGAKFPIKWTAPEAALYNR----FTIKSDVWSFGILMAE 428 Query: 542 MVSGRRNSDPSVENQDEV 595 +V+ R P + N + Sbjct: 429 IVTKGRIPYPGMTNAQTI 446
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 87.0 bits (214), Expect = 4e-17 Identities = 68/216 (31%), Positives = 110/216 (50%), Gaps = 19/216 (8%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N VAVK L+ T + F+ E + + H +VRL ++ +I E+M SL Sbjct: 267 NSTKVAVKTLKPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSL 326 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ S+ K+L P K++D + IA GM Y+ + + +H D++ N+L+ + Sbjct: 327 LDFL---KSDEGSKVLLP-KLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLM 379 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLA++ D A+ + + APE + NFG + KSDV+SFG+L+ E+V Sbjct: 380 CKIADFGLARV-IEDNEYTAREGAKFPIKWTAPE--AINFGCFTIKSDVWSFGILLYEIV 436 Query: 548 S-------GRRNSD-----------PSVEN-QDEVY 598 + GR N+D P +EN DE+Y Sbjct: 437 TYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELY 472
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 87.0 bits (214), Expect = 4e-17 Identities = 56/191 (29%), Positives = 108/191 (56%), Gaps = 1/191 (0%) Frame = +2 Query: 26 VKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 205 +K+++ + + + F NEVA + H NI+ MG+ ++ A++ ++ SL K++ Sbjct: 377 LKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHL-- 433 Query: 206 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDF 385 HV ++ +++DIA A+GM+YLH + I+H D+K +NI L KI DF Sbjct: 434 HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDF 487 Query: 386 GLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRN 562 GLA + +R + G++ ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 488 GLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELP 547 Query: 563 SDPSVENQDEV 595 + N+D++ Sbjct: 548 YS-HINNRDQI 557
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 87.0 bits (214), Expect = 4e-17 Identities = 65/195 (33%), Positives = 98/195 (50%), Gaps = 3/195 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 R+ +AVK L+ EF+ E A + +HH N+VRL+G C+ +I E+M N + Sbjct: 332 RHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGN 391 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L +Y+ + LL P ++ +A IA GM YL + +H D+ N L+ + Sbjct: 392 LLEYL----RRTDKSLLPPIILVQMASQIASGMSYLEA---RHFIHRDLAARNCLVSEHN 444 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLV 535 KI+DFGLA+ D T TA G + + APE F S KSDV++FG+L+ Sbjct: 445 IVKIADFGLARFMKED----TYTAHAGAKFPIKWTAPE--GLAFNTFSSKSDVWAFGVLL 498 Query: 536 LEMVSGRRNSDPSVE 580 E+ + P VE Sbjct: 499 WEIATYGMAPYPGVE 513
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 86.7 bits (213), Expect = 5e-17 Identities = 58/197 (29%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VPVA+K L++ E + +F++E A +G H NI+RL G + G ++ EYM N SL Sbjct: 661 VPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSL 720 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ +H + +++ + G+ GM YL + +H D+ N+L+D Sbjct: 721 DAFLRTHDGQFT-----IVQLVGMLRGVGAGMRYL---SDLGYIHRDLAARNVLVDGRLV 772 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL++ D ++ T + + + APE + F S SDV+SFG+++ E+ Sbjct: 773 CKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIA--FRTFSSASDVWSFGVVMWEV 830 Query: 545 VSGRRNSDPSVENQDEV 595 ++ ++ NQD + Sbjct: 831 LAYGERPYWNMTNQDVI 847
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 86.7 bits (213), Expect = 5e-17 Identities = 62/190 (32%), Positives = 101/190 (53%), Gaps = 3/190 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E EEF+ E A + I H N+V+L+G C+ ++ EYMP +L Y+ Sbjct: 314 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 373 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +++ + +L +A I+ MEYL + + +H D+ N L+ N K++ Sbjct: 374 ----RECNREEVTAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCLVGENHVVKVA 426 Query: 380 DFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++L D T TA G + + APE S + S KSDV++FG+L+ E+ + Sbjct: 427 DFGLSRLMTGD----TYTAHAGAKFPIKWTAPE--SLAYNTFSIKSDVWAFGVLLWEIAT 480 Query: 551 GRRNSDPSVE 580 + P ++ Sbjct: 481 YGMSPYPGID 490
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 86.7 bits (213), Expect = 5e-17 Identities = 56/191 (29%), Positives = 108/191 (56%), Gaps = 1/191 (0%) Frame = +2 Query: 26 VKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 205 +K+++ + + + F NEVA + H NI+ MG+ ++ A++ ++ SL K++ Sbjct: 110 LKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHL-- 166 Query: 206 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDF 385 HV ++ +++DIA A+GM+YLH + I+H D+K +NI L KI DF Sbjct: 167 HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHGGLTVKIGDF 220 Query: 386 GLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRN 562 GLA + +R + G++ ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 221 GLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELP 280 Query: 563 SDPSVENQDEV 595 + N+D++ Sbjct: 281 YS-HINNRDQI 290
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 86.7 bits (213), Expect = 5e-17 Identities = 56/191 (29%), Positives = 108/191 (56%), Gaps = 1/191 (0%) Frame = +2 Query: 26 VKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 205 +K+++ + + + F NEVA + H NI+ MG+ ++ A++ ++ SL K++ Sbjct: 377 LKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHL-- 433 Query: 206 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDF 385 HV ++ +++DIA A+GM+YLH + I+H D+K +NI L KI DF Sbjct: 434 HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDF 487 Query: 386 GLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRN 562 GLA + +R + G++ ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 488 GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP 547 Query: 563 SDPSVENQDEV 595 + N+D++ Sbjct: 548 YS-HINNRDQI 557
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 86.3 bits (212), Expect = 6e-17 Identities = 54/181 (29%), Positives = 103/181 (56%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEG--EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PV +K++E +G + + + +G + HA+IVRL+G C G+ L+ +Y+P SL Sbjct: 735 IPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSL 793 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ H ++ L P +L+ + IA+GM YL + ++H D+ N++L Sbjct: 794 LDHVKQH-----RETLGPQLLLNWGVQIAKGMYYLEE---HSMVHRDLALRNVMLKSPSQ 845 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 +++DFG+A L D L + A+ + ++A E S +FG +++SDV+S+G+ V E++ Sbjct: 846 VQVADFGVADLLPPDDKQLLHSEAKTPIKWMALE--SIHFGKYTHQSDVWSYGVTVWELM 903 Query: 548 S 550 + Sbjct: 904 T 904
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 86.3 bits (212), Expect = 6e-17 Identities = 54/181 (29%), Positives = 103/181 (56%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEG--EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PV +K++E +G + + + +G + HA+IVRL+G C G+ L+ +Y+P SL Sbjct: 735 IPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSL 793 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ H ++ L P +L+ + IA+GM YL + ++H D+ N++L Sbjct: 794 LDHVRQH-----RETLGPQLLLNWGVQIAKGMYYLEE---HSMVHRDLALRNVMLKSPSQ 845 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 +++DFG+A L D L + A+ + ++A E S +FG +++SDV+S+G+ V E++ Sbjct: 846 VQVADFGVADLLPPDDKQLLHSEAKTPIKWMALE--SIHFGKYTHQSDVWSYGVTVWELM 903 Query: 548 S 550 + Sbjct: 904 T 904
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 86.3 bits (212), Expect = 6e-17 Identities = 53/177 (29%), Positives = 97/177 (54%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVKM++ + +EF E T+ + H +V+ G CS+ ++ EY+ N L Y+ Sbjct: 442 VAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYL 501 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 SH K L P+++L++ + GM +L + + +H D+ N L+D + K+S Sbjct: 502 RSH-----GKGLEPSQLLEMCYDVCEGMAFLE---SHQFIHRDLAARNCLVDRDLCVKVS 553 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFG+ + DQ + ++ + + + APE++ ++ S KSDV++FG+L+ E+ S Sbjct: 554 DFGMTRYVLDDQYVSSV-GTKFPVKWSAPEVF--HYFKYSSKSDVWAFGILMWEVFS 607
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/197 (29%), Positives = 103/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VPVA+K L++ E + +F+ E A +G H NI+RL G + G ++ EYM N SL Sbjct: 29 VPVAIKALKAGYTERQRQDFLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSL 88 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ +H + +++ + G+ GM YL + +H D+ NIL+D Sbjct: 89 DAFLRTHDGQFT-----ILQLVGMLKGVGAGMRYL---SDLGYIHRDLAARNILVDGRLV 140 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL++ D ++ T + + + APE + F S SDV+SFG+++ E+ Sbjct: 141 CKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIA--FRTFSSASDVWSFGVVMWEV 198 Query: 545 VSGRRNSDPSVENQDEV 595 ++ ++ NQD + Sbjct: 199 LAYGERPYWNMTNQDVI 215
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/196 (30%), Positives = 111/196 (56%), Gaps = 4/196 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML + ++ F NEV + H NI+ MG+ ++ + A++ ++ SL Sbjct: 520 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLY 578 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ H+ +++ K++DIA A+GM+YLH + I+H D+K +NI L + Sbjct: 579 HHL--HIIETKFEMI---KLIDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTV 630 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + +R G++ ++APE + ++ S++SDVY+FG+++ E++ Sbjct: 631 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 690 Query: 548 SGRRNSDPSVENQDEV 595 +G+ ++ N+D++ Sbjct: 691 TGQLPYS-NINNRDQI 705
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 86.3 bits (212), Expect = 6e-17 Identities = 66/195 (33%), Positives = 96/195 (49%), Gaps = 5/195 (2%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRR--ALIYEYMPNE 181 G VAVK L+ ST E +F E+ + + H NIV+ G C RR LI EY+P Sbjct: 876 GEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYG 935 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL Y+ H I K K+L I +GMEYL +R +H D+ NIL++ Sbjct: 936 SLRDYLQKHKERIDHK-----KLLQYTSQICKGMEYLG---TKRYIHRDLATRNILVENE 987 Query: 362 FNPKISDFGLAKLCARDQSILTL-TAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 KI DFGL K+ +D+ + + + AP+ S S SDV+SFG+++ Sbjct: 988 NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPQ--SLTESKFSVASDVWSFGVVLY 1045 Query: 539 EMVSG-RRNSDPSVE 580 E+ + ++ P VE Sbjct: 1046 ELFTYIEKSKSPPVE 1060
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/196 (30%), Positives = 111/196 (56%), Gaps = 4/196 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML + ++ F NEV + H NI+ MG+ ++ + A++ ++ SL Sbjct: 106 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLY 164 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ H+ +++ K++DIA A+GM+YLH + I+H D+K +NI L + Sbjct: 165 HHL--HIIETKFEMI---KLIDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTV 216 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + +R G++ ++APE + ++ S++SDVY+FG+++ E++ Sbjct: 217 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 276 Query: 548 SGRRNSDPSVENQDEV 595 +G+ ++ N+D++ Sbjct: 277 TGQLPYS-NINNRDQI 291
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/196 (30%), Positives = 111/196 (56%), Gaps = 4/196 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML + ++ F NEV + H NI+ MG+ ++ + A++ ++ SL Sbjct: 90 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLY 148 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ H+ +++ K++DIA A+GM+YLH + I+H D+K +NI L + Sbjct: 149 HHL--HIIETKFEMI---KLIDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTV 200 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + +R G++ ++APE + ++ S++SDVY+FG+++ E++ Sbjct: 201 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 260 Query: 548 SGRRNSDPSVENQDEV 595 +G+ ++ N+D++ Sbjct: 261 TGQLPYS-NINNRDQI 275
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/196 (30%), Positives = 111/196 (56%), Gaps = 4/196 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML + ++ F NEV + H NI+ MG+ ++ + A++ ++ SL Sbjct: 480 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLY 538 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ H+ +++ K++DIA A+GM+YLH + I+H D+K +NI L + Sbjct: 539 HHL--HIIETKFEMI---KLIDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTV 590 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + +R G++ ++APE + ++ S++SDVY+FG+++ E++ Sbjct: 591 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 650 Query: 548 SGRRNSDPSVENQDEV 595 +G+ ++ N+D++ Sbjct: 651 TGQLPYS-NINNRDQI 665
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 86.3 bits (212), Expect = 6e-17 Identities = 57/183 (31%), Positives = 100/183 (54%), Gaps = 4/183 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFI----NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VAVK+L+ E EEF+ E + I +ANIV + ++G ++ EY+ ++L Sbjct: 36 VAVKVLKHEFTEDEEFVFKFKREASAAARIANANIVNIYDVGADGNVNYIVMEYVAGKTL 95 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 +K I + + K++D A IA+ + + H+ I+H DIKPHNI++ + Sbjct: 96 KKLIKENGK------IEFNKIIDYATQIAKALNFAHKN---GIVHRDIKPHNIMVTDDDI 146 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K++DFG+AK + + +I T G+ Y++PE V ++D+YSFG+++ EM Sbjct: 147 IKVTDFGIAK-ASNESTITTTNKVVGSAHYLSPE--QAQGIPVDCRTDIYSFGIVLYEMA 203 Query: 548 SGR 556 +G+ Sbjct: 204 TGK 206
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/196 (30%), Positives = 111/196 (56%), Gaps = 4/196 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML + ++ F NEV + H NI+ MG+ ++ + A++ ++ SL Sbjct: 42 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLY 100 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ H+ +++ K++DIA A+GM+YLH + I+H D+K +NI L + Sbjct: 101 HHL--HIIETKFEMI---KLIDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTV 152 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + +R G++ ++APE + ++ S++SDVY+FG+++ E++ Sbjct: 153 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 212 Query: 548 SGRRNSDPSVENQDEV 595 +G+ ++ N+D++ Sbjct: 213 TGQLPYS-NINNRDQI 227
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 86.3 bits (212), Expect = 6e-17 Identities = 56/191 (29%), Positives = 108/191 (56%), Gaps = 1/191 (0%) Frame = +2 Query: 26 VKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 205 +K+++ + + + F NEVA + H NI+ MG+ ++ A++ ++ SL K++ Sbjct: 377 LKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHL-- 433 Query: 206 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDF 385 HV ++ +++DIA A+GM+YLH + I+H D+K +NI L KI DF Sbjct: 434 HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDF 487 Query: 386 GLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRN 562 GLA + +R + G++ ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 488 GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP 547 Query: 563 SDPSVENQDEV 595 + N+D++ Sbjct: 548 YS-HINNRDQI 557
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 86.3 bits (212), Expect = 6e-17 Identities = 59/196 (30%), Positives = 111/196 (56%), Gaps = 4/196 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML + ++ F NEV + H NI+ MG+ ++ + A++ ++ SL Sbjct: 520 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLY 578 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ H+ +++ K++DIA A+GM+YLH + I+H D+K +NI L + Sbjct: 579 HHL--HIIETKFEMI---KLIDIARQTAQGMDYLHA---KSIIHRDLKSNNIFLHEDLTV 630 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + +R G++ ++APE + ++ S++SDVY+FG+++ E++ Sbjct: 631 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 690 Query: 548 SGRRNSDPSVENQDEV 595 +G+ ++ N+D++ Sbjct: 691 TGQLPYS-NINNRDQI 705
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 85.9 bits (211), Expect = 8e-17 Identities = 56/191 (29%), Positives = 108/191 (56%), Gaps = 1/191 (0%) Frame = +2 Query: 26 VKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 205 +K+++ + + + F NEVA + H NI+ MG+ ++ A++ ++ SL K++ Sbjct: 377 LKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHL-- 433 Query: 206 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDF 385 HV ++ +++DIA A+GM+YLH + I+H D+K +NI L KI DF Sbjct: 434 HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDF 487 Query: 386 GLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRN 562 GLA + +R + G++ ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 488 GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGEL- 546 Query: 563 SDPSVENQDEV 595 + N+D++ Sbjct: 547 PYAHINNRDQI 557
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 85.9 bits (211), Expect = 8e-17 Identities = 56/191 (29%), Positives = 108/191 (56%), Gaps = 1/191 (0%) Frame = +2 Query: 26 VKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFS 205 +K+++ + + + F NEVA + H NI+ MG+ ++ A++ ++ SL K++ Sbjct: 52 LKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHL-- 108 Query: 206 HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDF 385 HV ++ +++DIA A+GM+YLH + I+H D+K +NI L KI DF Sbjct: 109 HVQETKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDF 162 Query: 386 GLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRN 562 GLA + +R + G++ ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 163 GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGEL- 221 Query: 563 SDPSVENQDEV 595 + N+D++ Sbjct: 222 PYAHINNRDQI 232
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 85.9 bits (211), Expect = 8e-17 Identities = 58/182 (31%), Positives = 100/182 (54%), Gaps = 3/182 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VPVA+K L++ E + +F+ E +G H NI+RL G S+ +I EYM N +L Sbjct: 641 VPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGAL 700 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 +K++ S +++ + GIA GM+YL N +H D+ NIL++ N Sbjct: 701 DKFLREKDGEFS-----VLQLVGMLRGIAAGMKYL---ANMNYVHRDLAARNILVNSNLV 752 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + + APE S + + SDV+SFG+++ E+ Sbjct: 753 CKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS--YRKFTSASDVWSFGIVMWEV 810 Query: 545 VS 550 ++ Sbjct: 811 MT 812
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 85.5 bits (210), Expect = 1e-16 Identities = 55/181 (30%), Positives = 102/181 (56%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEG--EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PV +K++E +G + + + IG + HA+IVRL+G C G+ L+ +Y+P SL Sbjct: 737 IPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSL 795 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ H + L P +L+ + IA+GM YL + ++H ++ N+LL Sbjct: 796 LDHVRQH-----RGALGPQLLLNWGVQIAKGMYYLEE---HGMVHRNLAARNVLLKSPSQ 847 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 +++DFG+A L D L + A+ + ++A L S +FG +++SDV+S+G+ V E++ Sbjct: 848 VQVADFGVADLLPPDDKQLLYSEAKTPIKWMA--LESIHFGKYTHQSDVWSYGVTVWELM 905 Query: 548 S 550 + Sbjct: 906 T 906
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 85.5 bits (210), Expect = 1e-16 Identities = 55/181 (30%), Positives = 102/181 (56%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEG--EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PV +K++E +G + + + IG + HA+IVRL+G C G+ L+ +Y+P SL Sbjct: 737 IPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSL 795 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ H + L P +L+ + IA+GM YL + ++H ++ N+LL Sbjct: 796 LDHVRQH-----RGALGPQLLLNWGVQIAKGMYYLEE---HGMVHRNLAARNVLLKSPSQ 847 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 +++DFG+A L D L + A+ + ++A L S +FG +++SDV+S+G+ V E++ Sbjct: 848 VQVADFGVADLLPPDDKQLLYSEAKTPIKWMA--LESIHFGKYTHQSDVWSYGVTVWELM 905 Query: 548 S 550 + Sbjct: 906 T 906
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 85.1 bits (209), Expect = 1e-16 Identities = 53/171 (30%), Positives = 90/171 (52%), Gaps = 4/171 (2%) Frame = +2 Query: 59 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 + F++E+ + L HH NI+ L + +E + LIY YM N +L F + + Sbjct: 207 KRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTL----FDRLQCVGDTAPL 262 Query: 239 PTKM-LDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKL---CA 406 P + + I +GI++ + YLH ++ I NILLD F PK++DF +A Sbjct: 263 PWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLE 322 Query: 407 RDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 + +T++ + PE Y R G +S K+DVYSFG++++E+++G R Sbjct: 323 HQSCTINMTSSSSKHLWYMPEEYIRQ-GKLSIKTDVYSFGIVIMEVLTGCR 372
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 85.1 bits (209), Expect = 1e-16 Identities = 68/216 (31%), Positives = 108/216 (50%), Gaps = 19/216 (8%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N VAVK L+ T + F+ E + + H +VRL ++ +I E+M SL Sbjct: 267 NSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSL 326 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ S K+L P K++D + IA GM Y+ + + +H D++ N+L+ + Sbjct: 327 LDFLKSDEGG---KVLLP-KLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLM 379 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLA++ D A+ + + APE NFG + KSDV+SFG+L+ E+V Sbjct: 380 CKIADFGLARVI-EDNEYTAREGAKFPIKWTAPEAI--NFGCFTIKSDVWSFGILLYEIV 436 Query: 548 S-------GRRNSD-----------PSVEN-QDEVY 598 + GR N+D P +EN DE+Y Sbjct: 437 TYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELY 472
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 84.7 bits (208), Expect = 2e-16 Identities = 62/190 (32%), Positives = 101/190 (53%), Gaps = 3/190 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E EEF+ E A + I H N+V+L+G C+ +I E+M +L Y+ Sbjct: 217 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL 276 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +++ + +L +A I+ MEYL + + +H D+ N L+ N K++ Sbjct: 277 ----RECNRQEVNAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCLVGENHLVKVA 329 Query: 380 DFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++L D T TA GT + + APE S + S KSDV++FG+L+ E+ + Sbjct: 330 DFGLSRLMTGD----TYTAHAGTKFPIKWTAPE--SLAYNKFSIKSDVWAFGVLLWEIAT 383 Query: 551 GRRNSDPSVE 580 + P ++ Sbjct: 384 YGMSPYPGID 393
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 84.7 bits (208), Expect = 2e-16 Identities = 54/177 (30%), Positives = 97/177 (54%) Frame = +2 Query: 14 VPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 +PVAVK+++S+ + + E+ + + H ++RL CS G ++ E M +L+ Sbjct: 257 IPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQV 316 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 Y+ S K L+ +L A +A GM YL + +R++H D+ N+L+ + K Sbjct: 317 YLGSS----EGKALSLPHLLGFACQVAEGMSYLEE---RRVVHRDLAARNVLVGDDLTCK 369 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 ++DFGLA+L +D + ++ + + APE + N+ S KSDV+SFG+L+ E+ Sbjct: 370 VADFGLARL-LKDDVYSPSSGSKIPVKWTAPE--AANYRVFSQKSDVWSFGILLYEV 423
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 84.3 bits (207), Expect = 2e-16 Identities = 59/197 (29%), Positives = 99/197 (50%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 RN + VAVK L T F+ E A + H +V L CS+ ++ EYM S Sbjct: 304 RNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGS 363 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L ++ + L ++ IA +A GMEYL +++++H D+ N+L+ N Sbjct: 364 LLDFL----REGDGRYLHFEDLIYIATQVASGMEYLE---SKQLIHRDLAARNVLIGENN 416 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 KI DFGLA++ A D +R + + APE +G S KSDV+S+G+L++E+ Sbjct: 417 VAKICDFGLARVIA-DDEYCPKQGSRFPVKWTAPEAII--YGKFSIKSDVWSYGILLMEL 473 Query: 545 VSGRRNSDPSVENQDEV 595 + + P + +++ + Sbjct: 474 FTYGQVPYPGMHSREVI 490
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 84.3 bits (207), Expect = 2e-16 Identities = 62/187 (33%), Positives = 99/187 (52%), Gaps = 10/187 (5%) Frame = +2 Query: 20 VAVKMLESSTGEGE-------EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 VAVKM+ T + E +F +EVA + + H NIV+ + C + +I EYM Sbjct: 110 VAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQ 169 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L Y+ + L+ +L +AL I+RGMEYLH +Q ++H D+K +N+LL+ Sbjct: 170 GNLRMYL----NKKEPYSLSIETVLRLALDISRGMEYLH---SQGVIHRDLKSNNLLLND 222 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMG---YIAPELYSRNFGGVSYKSDVYSFGM 529 K++DFG + C Q A+G MG ++APE+ + K DVYSFG+ Sbjct: 223 EMRVKVADFGTS--CLETQ----CREAKGNMGTYRWMAPEMIKEK--PYTRKVDVYSFGI 274 Query: 530 LVLEMVS 550 ++ E+ + Sbjct: 275 VLWELTT 281
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 84.3 bits (207), Expect = 2e-16 Identities = 59/182 (32%), Positives = 102/182 (56%), Gaps = 4/182 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVK+L+ + E+ F NEVA + H NI+ MG+ ++ A++ ++ SL Sbjct: 363 VAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSL- 420 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 Y HV + ++ +++DIA A+GM+YLH + I+H D+K +NI L Sbjct: 421 -YYHLHVLDTKFQMF---QLIDIARQTAQGMDYLHA---KNIIHRDMKSNNIFLHEGLTV 473 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + R + G++ ++APE + ++ S++SDVYS+G+++ E++ Sbjct: 474 KIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 533 Query: 548 SG 553 +G Sbjct: 534 TG 535
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 84.0 bits (206), Expect = 3e-16 Identities = 63/182 (34%), Positives = 89/182 (48%), Gaps = 4/182 (2%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG-EEFINEVATIGLIHHANIVRLMGFCSEGTRR--ALIYEYMPNE 181 G VAVK L+ ST E +F E+ + + H NIV+ G C RR LI EY+P Sbjct: 876 GEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYG 935 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL Y+ H I K+L I +GMEYL +R +H D+ NIL++ Sbjct: 936 SLRDYLQKHKERIDH-----IKLLQYTSQICKGMEYLG---TKRYIHRDLATRNILVENE 987 Query: 362 FNPKISDFGLAKLCARDQSILTL-TAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 KI DFGL K+ +D+ + + + APE S S SDV+SFG+++ Sbjct: 988 NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE--SLTESKFSVASDVWSFGVVLY 1045 Query: 539 EM 544 E+ Sbjct: 1046 EL 1047
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 84.0 bits (206), Expect = 3e-16 Identities = 61/190 (32%), Positives = 101/190 (53%), Gaps = 3/190 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E EEF+ E A + I H N+V+L+G C+ +I E+M +L Y+ Sbjct: 154 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL 213 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +++ ++ +L +A I+ MEYL + + +H D+ N L+ N K++ Sbjct: 214 ----RECNRQEVSAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCLVGENHLVKVA 266 Query: 380 DFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++L D T TA G + + APE S + S KSDV++FG+L+ E+ + Sbjct: 267 DFGLSRLMTGD----TYTAHAGAKFPIKWTAPE--SLAYNKFSIKSDVWAFGVLLWEIAT 320 Query: 551 GRRNSDPSVE 580 + P ++ Sbjct: 321 YGMSPYPGID 330
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 84.0 bits (206), Expect = 3e-16 Identities = 61/190 (32%), Positives = 101/190 (53%), Gaps = 3/190 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E EEF+ E A + I H N+V+L+G C+ +I E+M +L Y+ Sbjct: 268 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL 327 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +++ ++ +L +A I+ MEYL + + +H D+ N L+ N K++ Sbjct: 328 ----RECNRQEVSAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCLVGENHLVKVA 380 Query: 380 DFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++L D T TA G + + APE S + S KSDV++FG+L+ E+ + Sbjct: 381 DFGLSRLMTGD----TYTAHAGAKFPIKWTAPE--SLAYNKFSIKSDVWAFGVLLWEIAT 434 Query: 551 GRRNSDPSVE 580 + P ++ Sbjct: 435 YGMSPYPGID 444
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 83.6 bits (205), Expect = 4e-16 Identities = 53/177 (29%), Positives = 97/177 (54%) Frame = +2 Query: 14 VPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 +PVA+K+++S+ + + E+ T+ + H ++RL CS G ++ E M +L+ Sbjct: 253 LPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQA 312 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + L +L A +A GM YL + QR++H D+ N+L+D K Sbjct: 313 FL----GTPEGRALRLPPLLGFACQVAEGMSYLEE---QRVVHRDLAARNVLVDDGLACK 365 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 ++DFGLA+L +D ++++ + + APE + N+ S KSDV+SFG+L+ E+ Sbjct: 366 VADFGLARL-LKDDIYSPSSSSKIPVKWTAPE--AANYRVFSQKSDVWSFGVLLHEV 419
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 83.6 bits (205), Expect = 4e-16 Identities = 52/177 (29%), Positives = 95/177 (53%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVKM++ +EF E T+ + H +V+ G CS+ ++ EY+ N L Y+ Sbjct: 418 VAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYL 477 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 SH K L ++L++ + GM +L + + +H D+ N L+D + + K+S Sbjct: 478 KSH-----GKGLESCQLLEMCYDVCEGMAFLE---SHQFIHRDLAARNCLVDSDLSVKVS 529 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFG+ + DQ + ++ + + + APE++ ++ S KSDV++FG+L+ E+ S Sbjct: 530 DFGMTRYVLDDQYVSSV-GTKFPVKWSAPEVF--HYFKYSSKSDVWAFGILMWEVFS 583
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 83.6 bits (205), Expect = 4e-16 Identities = 55/180 (30%), Positives = 92/180 (51%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 R +PVA+K + + E+FI E + + H+ +V+L G C + ++ E+M N Sbjct: 291 RAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGC 350 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L Y+ + + LL L + I GM YL + C +H D+ N L+ Sbjct: 351 LLDYLRERKGQLQKALL-----LSMCQDICEGMAYLERSC---YIHRDLAARNCLVSSAC 402 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 KISDFG+A+ D+ I + + A+ + + PE++ +F S KSDV+SFG+L+ E+ Sbjct: 403 VVKISDFGMARYVLDDEYI-SSSGAKFPVKWCPPEVF--HFNKYSSKSDVWSFGVLMWEV 459
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 83.6 bits (205), Expect = 4e-16 Identities = 55/183 (30%), Positives = 96/183 (52%), Gaps = 3/183 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 R + AVKM++ T ++FI E + + H N+V+L G CS+ ++ EYM + S Sbjct: 546 RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGS 605 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L Y+ H + + +LD+ + +++GM YL + +H D+ N L+ Sbjct: 606 LLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLER---HNYIHRDLAARNCLVGSEN 659 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLV 535 K++DFGLA+ DQ T++ GT + + PE+ N+ S KSDV+++G+L+ Sbjct: 660 VVKVADFGLARYVLDDQ----YTSSGGTKFPIKWAPPEVL--NYTRFSSKSDVWAYGVLM 713 Query: 536 LEM 544 E+ Sbjct: 714 WEI 716
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 83.6 bits (205), Expect = 4e-16 Identities = 56/197 (28%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L++ E + +F++E + +G H NI+RL G + ++ EYM N SL Sbjct: 653 IQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSL 712 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ H + ++L + GIA GM+YL + +H D+ NIL++ N Sbjct: 713 DTFLKKHDGQFT-----VIQLLGMLRGIAAGMQYLSE---MNYVHRDLAARNILVNRNLV 764 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + APE + + + SDV+S+G+++ E+ Sbjct: 765 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIT--YRKFTSASDVWSYGIVMWEV 822 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 823 ISYGERPYWEMSNQDVI 839
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 83.6 bits (205), Expect = 4e-16 Identities = 62/192 (32%), Positives = 99/192 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ + + F+ E + + H +VRL ++ +I EYM N SL ++ Sbjct: 269 VAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIY-IITEYMENGSLVDFL 327 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S L K+LD+A IA GM ++ + Q +H D++ NIL+ + KI+ Sbjct: 328 ----KTPSGIKLNVNKLLDMAAQIAEGMAFIEE---QNYIHRDLRAANILVSDTLSCKIA 380 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE N+G + KSDV+SFG+L+ E+V+ R Sbjct: 381 DFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTFTIKSDVWSFGILLTEIVTHGR 437 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 438 IPYPGMTNPEVI 449
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 83.6 bits (205), Expect = 4e-16 Identities = 56/183 (30%), Positives = 96/183 (52%), Gaps = 4/183 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFIN----EVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VA+K+L EFI E + + H NIV + E ++ EY+ +L Sbjct: 37 VAIKILRFDYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTL 96 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++YI ++ L P + L+I I + + HQ +I+H DIKPHNIL+D+ N Sbjct: 97 KEYITANGP------LHPKEALNIMEQIVSAIAHAHQN---QIVHRDIKPHNILIDHMGN 147 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K++DFG+A + +I + G++ Y++PE G + KSD+Y+ G+++ E++ Sbjct: 148 IKVTDFGIATALS-STTITHTNSVLGSVHYLSPE--QARGGLATKKSDIYALGIVLFELL 204 Query: 548 SGR 556 +GR Sbjct: 205 TGR 207
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 82.8 bits (203), Expect = 7e-16 Identities = 55/197 (27%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L+ E + +F+ E + +G H NI+RL G ++ ++ EYM N SL Sbjct: 648 ISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSL 707 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ H + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 708 DSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLV 759 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + +PE S + + SDV+S+G+++ E+ Sbjct: 760 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAMS--YRKFTSASDVWSYGIVLWEV 817 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 818 MSYGERPYSQMSNQDVI 834
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 82.8 bits (203), Expect = 7e-16 Identities = 61/195 (31%), Positives = 104/195 (53%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 R G VAVK L+ T ++F+ E A + + H N+V+L+G C+ +I E+M + + Sbjct: 392 RYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGN 451 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L ++ S ++ L +L +A IA GM YL ++ +H D+ N L+ N Sbjct: 452 LLDFLRS----AGRETLDAVALLYMATQIASGMSYLE---SRNYIHRDLAARNCLVGDNK 504 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K++DFGLA+L RD + A+ + + APE + N S KSDV++FG+L+ E+ Sbjct: 505 LVKVADFGLARL-MRDDTYTAHAGAKFPIKWTAPEGLAYN--KFSTKSDVWAFGVLLWEI 561 Query: 545 VSGRRNSDPSVENQD 589 + + P+++ D Sbjct: 562 ATYGMSPYPAIDLTD 576
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 82.8 bits (203), Expect = 7e-16 Identities = 57/176 (32%), Positives = 92/176 (52%), Gaps = 2/176 (1%) Frame = +2 Query: 38 ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSN 217 E+++ E E + I +IV + G C + ++ E+M + SLEK + +H Sbjct: 71 ETTSSEVTCLFEEAVKMEKIKFQHIVSIYGVCKQPL--GIVMEFMASGSLEKTLPTH--- 125 Query: 218 ISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK 397 L P K L I + M +LH +LH D+KP NILLD N + KISDFGL+K Sbjct: 126 ---SLCWPLK-LRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLDNNMHVKISDFGLSK 180 Query: 398 LC--ARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 + + + +A RGT+ YI PE++ N + DVYSF +++ E+++ ++ Sbjct: 181 WMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKK 236
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 82.8 bits (203), Expect = 7e-16 Identities = 61/190 (32%), Positives = 100/190 (52%), Gaps = 3/190 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E EEF+ E A + I H N+V+L+G C+ +I E+M +L Y+ Sbjct: 268 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL 327 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +++ + +L +A I+ MEYL + + +H D+ N L+ N K++ Sbjct: 328 ----RECNRQEVNAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCLVGENHLVKVA 380 Query: 380 DFGLAKLCARDQSILTLTAARGT---MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++L D T TA G + + APE S + S KSDV++FG+L+ E+ + Sbjct: 381 DFGLSRLMTGD----TYTAHAGAKFPIKWTAPE--SLAYNKFSIKSDVWAFGVLLWEIAT 434 Query: 551 GRRNSDPSVE 580 + P ++ Sbjct: 435 YGMSPYPGID 444
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 82.8 bits (203), Expect = 7e-16 Identities = 62/192 (32%), Positives = 98/192 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ + + F+ E + + H +VRL +E +I EYM N SL ++ Sbjct: 269 VAVKSLKQGSMSPDAFLAEANLMKQLQHKRLVRLYAVVTEEPIY-IITEYMENGSLVDFL 327 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S L K+LD+A I GM +L + + +H D++ NIL+ + KI+ Sbjct: 328 ----KTPSGIKLTINKLLDMAAQIVEGMAFLEE---RNYIHRDLRAANILVSDTLSCKIA 380 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE N+G + KSDV+SFG+L+ E+V+ R Sbjct: 381 DFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTFTIKSDVWSFGILMTEIVTHGR 437 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 438 IPYPGMTNPEVI 449
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 82.4 bits (202), Expect = 9e-16 Identities = 60/198 (30%), Positives = 106/198 (53%), Gaps = 6/198 (3%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+S E + +F++E + +G H N++ L G ++ T +I E+M N SL+ Sbjct: 650 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDS 709 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL + +H D+ NIL++ N K Sbjct: 710 FLRQNDGQFT-----VIQLVGMLRGIAAGMKYL---ADMNYVHRDLAARNILVNSNLVCK 761 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 +SDFGL++ D S T T+A G + + APE + R F + SDV+S+G+++ E Sbjct: 762 VSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKF---TSASDVWSYGIVMWE 818 Query: 542 MVSGRRNSDPSVENQDEV 595 ++S + NQD + Sbjct: 819 VMSYGERPYWDMTNQDVI 836
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 82.4 bits (202), Expect = 9e-16 Identities = 60/198 (30%), Positives = 106/198 (53%), Gaps = 6/198 (3%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+S E + +F++E + +G H N++ L G ++ T +I E+M N SL+ Sbjct: 658 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDS 717 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL + +H D+ NIL++ N K Sbjct: 718 FLRQNDGQFT-----VIQLVGMLRGIAAGMKYL---ADMNYVHRDLAARNILVNSNLVCK 769 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 +SDFGL++ D S T T+A G + + APE + R F + SDV+S+G+++ E Sbjct: 770 VSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKF---TSASDVWSYGIVMWE 826 Query: 542 MVSGRRNSDPSVENQDEV 595 ++S + NQD + Sbjct: 827 VMSYGERPYWDMTNQDVI 844
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 82.4 bits (202), Expect = 9e-16 Identities = 55/176 (31%), Positives = 92/176 (52%), Gaps = 2/176 (1%) Frame = +2 Query: 38 ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSN 217 ++++ + I E A + I +IV + G C + ++ E+M N SLEK + +H + Sbjct: 59 DAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL--GIVMEFMANGSLEKVLSTH--S 114 Query: 218 ISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK 397 + KL I + M +LH +LH D+KP NILLD N + KISDFGL+K Sbjct: 115 LCWKL-----RFRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLDSNMHVKISDFGLSK 168 Query: 398 LCARD--QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 + + +A RG + YI PE++ + K DVYSF +++ E+++ ++ Sbjct: 169 WMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKK 224
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 82.4 bits (202), Expect = 9e-16 Identities = 55/182 (30%), Positives = 101/182 (55%), Gaps = 3/182 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L++ E + +F++E + +G H NI+ L G S+ +I EYM N +L Sbjct: 642 IPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIPLEGVVSKYKPMMIITEYMENGAL 701 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 +K++ S +++ + GIA GM+YL N +H D+ NIL++ N Sbjct: 702 DKFLREKDGEFS-----VLQLVGMLRGIASGMKYL---ANMNYVHRDLAARNILVNSNLV 753 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + + APE S + + SDV+S+G+++ E+ Sbjct: 754 CKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS--YRKFTSASDVWSYGIVMWEV 811 Query: 545 VS 550 ++ Sbjct: 812 MT 813
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 82.4 bits (202), Expect = 9e-16 Identities = 61/192 (31%), Positives = 99/192 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ + + F+ E + + H +VRL ++ +I EYM N SL ++ Sbjct: 269 VAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFL 327 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S L K+LD+A IA GM ++ + + +H D++ NIL+ + KI+ Sbjct: 328 ----KTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDLRAANILVSDTLSCKIA 380 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE N+G + KSDV+SFG+L+ E+V+ R Sbjct: 381 DFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTFTIKSDVWSFGILLTEIVTHGR 437 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 438 IPYPGMTNPEVI 449
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 82.4 bits (202), Expect = 9e-16 Identities = 61/192 (31%), Positives = 99/192 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ + + F+ E + + H +VRL ++ +I EYM N SL ++ Sbjct: 269 VAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFL 327 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S L K+LD+A IA GM ++ + + +H D++ NIL+ + KI+ Sbjct: 328 ----KTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDLRAANILVSDTLSCKIA 380 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE N+G + KSDV+SFG+L+ E+V+ R Sbjct: 381 DFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTFTIKSDVWSFGILLTEIVTHGR 437 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 438 IPYPGMTNPEVI 449
>SHARK_DROME (Q24145) Tyrosine-protein kinase shark (EC 2.7.10.2)| Length = 939 Score = 82.0 bits (201), Expect = 1e-15 Identities = 60/178 (33%), Positives = 90/178 (50%), Gaps = 1/178 (0%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+KML +EF+ E + + + H IVRL+G ++G ++ E P S+ +YI Sbjct: 695 VAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYI 753 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 H ++ A ++ A IA GM YL +Q +H D+ NILL KIS Sbjct: 754 LDH----GHEITANAELKVWASQIACGMHYLE---SQHFVHRDLAARNILLTARHQAKIS 806 Query: 380 DFGLAKLCARDQSILTLT-AARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFG+++ + T R + + APE S N G S+ SDV+SFG+ + EM S Sbjct: 807 DFGMSRSLRPGSTEYQFTQGGRWPIRWYAPE--SFNLGIFSHASDVWSFGVTIWEMFS 862
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 82.0 bits (201), Expect = 1e-15 Identities = 56/194 (28%), Positives = 98/194 (50%), Gaps = 2/194 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSE--GTRRALIYEYMPNESLEK 193 VA KML+SS E E+F+ E + + H IV L+G C+E +I EYM N SL++ Sbjct: 245 VAAKMLQSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKE 304 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 Y+ K +M+ + I+ GM YL +++++H D++ NIL+ + K Sbjct: 305 YL----KTPDGKKTNLNQMVHMMAEISEGMAYLE---SEKVVHRDLRADNILVANDLTRK 357 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 ++DFGL +L R + APE + KSDV+S+G+++ E+++ Sbjct: 358 VADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKV--FTSKSDVWSYGIVMFEILTW 415 Query: 554 RRNSDPSVENQDEV 595 + P + ++ + Sbjct: 416 ASSPYPDIPAKEVI 429
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/201 (28%), Positives = 105/201 (52%), Gaps = 4/201 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 + V VA+K L+ E + +F+ E + +G H N+V L G + G ++ EYM N Sbjct: 652 KRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMEN 711 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ H + +++ + GIA GM YL + +H D+ NIL++ Sbjct: 712 GALDAFLRKHDGQFT-----VIQLVGMLRGIAAGMRYL---ADMGYVHRDLAARNILVNS 763 Query: 359 NFNPKISDFGLAKLCARD-QSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGML 532 N K+SDFGL+++ D +++ T T + + + APE + R F + SDV+S+G++ Sbjct: 764 NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKF---TSASDVWSYGIV 820 Query: 533 VLEMVSGRRNSDPSVENQDEV 595 + E++S + NQD + Sbjct: 821 MWEVMSYGERPYWDMSNQDVI 841
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 81.6 bits (200), Expect = 2e-15 Identities = 59/195 (30%), Positives = 104/195 (53%), Gaps = 3/195 (1%) Frame = +2 Query: 14 VPVAVKMLESSTG--EGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L STG EEF+ E + H N+++L+ C ++ LI + MP L Sbjct: 966 IPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMS-SQMMLITQLMPLGCL 1024 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 Y+ ++ I K L L+ + IA+GM YL + +R++H D+ N+L+ Sbjct: 1025 LDYVRNNRDKIGSKAL-----LNWSTQIAKGMSYLEE---KRLVHRDLAARNVLVQTPSL 1076 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEM 544 KI+DFGLAKL + D + + + ++A E + +R F + KSDV++FG+ + E+ Sbjct: 1077 VKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVF---TSKSDVWAFGVTIWEL 1133 Query: 545 VSGRRNSDPSVENQD 589 ++ + ++ +D Sbjct: 1134 LTFGQRPHENIPAKD 1148
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 81.3 bits (199), Expect = 2e-15 Identities = 57/197 (28%), Positives = 103/197 (52%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L++ E + +F+ E + +G H NI+RL G + ++ E+M N +L+ Sbjct: 638 VAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDS 697 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ ++ +++ I GIA GM+YL + +H D+ NIL++ N K Sbjct: 698 FL-----RMNDGQFTVIQLVGILRGIASGMKYLSE---MNYVHRDLAARNILVNSNLVCK 749 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ +S T T+A G + + APE S + + SDV+S+G+++ E+ Sbjct: 750 VSDFGLSRFLENSRSDPTYTSALGGKIPIRWTAPEAIS--YRKFTSASDVWSYGIVMWEV 807 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 808 MSYGERPYWDMSNQDVI 824
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 80.9 bits (198), Expect = 3e-15 Identities = 59/198 (29%), Positives = 106/198 (53%), Gaps = 6/198 (3%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+S E + +F++E + +G H N++ L G ++ + +I E+M N SL+ Sbjct: 668 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDS 727 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL + +H D+ NIL++ N K Sbjct: 728 FLRQNDGQFTV-----IQLVGMLRGIAAGMKYL---ADMNYVHRDLAARNILVNSNLVCK 779 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 +SDFGL++ D S T T+A G + + APE + R F + SDV+S+G+++ E Sbjct: 780 VSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKF---TSASDVWSYGIVMWE 836 Query: 542 MVSGRRNSDPSVENQDEV 595 ++S + NQD + Sbjct: 837 VMSYGERPYWDMTNQDVI 854
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 80.9 bits (198), Expect = 3e-15 Identities = 62/194 (31%), Positives = 100/194 (51%), Gaps = 5/194 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E ++F+ E + IHH N+++L C+ G ++ E M S+ +Y+ Sbjct: 91 VAVKTLKPDTMEVKDFVQEAQVMKKIHHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYL 150 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K + +M+D++ IA GM YL +H D+ NIL+ K++ Sbjct: 151 ----KHGEGKNITLHQMVDMSAQIASGMTYLEA---HSYIHRDLAARNILVGEGNVCKVA 203 Query: 380 DFGLAKLCARDQSILTLTAARGT---MGYIAPE--LYSRNFGGVSYKSDVYSFGMLVLEM 544 DFGLA++ D GT + + APE LY+R + KSDV+SFG+L+ E+ Sbjct: 204 DFGLARVIKED----IYNPREGTKFPIKWTAPEAALYNR----FTIKSDVWSFGVLISEI 255 Query: 545 VSGRRNSDPSVENQ 586 V+ R P + N+ Sbjct: 256 VTHGRMPYPGMTNR 269
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 80.9 bits (198), Expect = 3e-15 Identities = 59/190 (31%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +VRL SE ++ EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVRLYAVVSEEPIY-IVTEYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 460 VPYPGMVNRE 469
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 80.9 bits (198), Expect = 3e-15 Identities = 59/193 (30%), Positives = 103/193 (53%), Gaps = 3/193 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T EEF+ E + + + H +++L C++ ++ E M SL +Y+ Sbjct: 265 VAVKTLKPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYL 324 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +L +++D+A +A GM YL Q Q +H D+ NIL+ + K++ Sbjct: 325 RG-----EDGVLKIEQLVDVAAQVASGMSYLEQ---QNYIHRDLAARNILVGEHGICKVA 376 Query: 380 DFGLAKLCARDQSILTL-TAARGTMGYIAPE--LYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGLA++ D+ I T A+ + + APE +Y+R + KSDV+SFG+++ E+++ Sbjct: 377 DFGLARVI--DEEIYEAHTGAKFPIKWTAPEAAMYNR----FTIKSDVWSFGVVLYEIIT 430 Query: 551 GRRNSDPSVENQD 589 R P + N + Sbjct: 431 YGRFPYPGMTNPE 443
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 80.5 bits (197), Expect = 3e-15 Identities = 57/201 (28%), Positives = 105/201 (52%), Gaps = 4/201 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 + V VA+K L+ E + +F+ E + +G H N+V L G + G ++ E+M N Sbjct: 657 KRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMEN 716 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ H + +++ + GIA GM YL + +H D+ NIL++ Sbjct: 717 GALDAFLRKHDGQFT-----VIQLVGMLRGIAAGMRYL---ADMGYVHRDLAARNILVNS 768 Query: 359 NFNPKISDFGLAKLCARD-QSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGML 532 N K+SDFGL+++ D +++ T T + + + APE + R F + SDV+S+G++ Sbjct: 769 NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKF---TSASDVWSYGIV 825 Query: 533 VLEMVSGRRNSDPSVENQDEV 595 + E++S + NQD + Sbjct: 826 MWEVMSYGERPYWDMSNQDVI 846
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 80.5 bits (197), Expect = 3e-15 Identities = 57/201 (28%), Positives = 105/201 (52%), Gaps = 4/201 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 + V VA+K L+ E + +F+ E + +G H N+V L G + G ++ E+M N Sbjct: 657 KRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMEN 716 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ H + +++ + GIA GM YL + +H D+ NIL++ Sbjct: 717 GALDAFLRKHDGQFT-----VIQLVGMLRGIAAGMRYL---ADMGYVHRDLAARNILVNS 768 Query: 359 NFNPKISDFGLAKLCARD-QSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGML 532 N K+SDFGL+++ D +++ T T + + + APE + R F + SDV+S+G++ Sbjct: 769 NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKF---TSASDVWSYGIV 825 Query: 533 VLEMVSGRRNSDPSVENQDEV 595 + E++S + NQD + Sbjct: 826 MWEVMSYGERPYWDMSNQDVI 846
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 80.5 bits (197), Expect = 3e-15 Identities = 57/214 (26%), Positives = 108/214 (50%), Gaps = 17/214 (7%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPN 178 N VAVKM++ + + + E+ + +I H NI+ L+G CS+ +I EY P+ Sbjct: 436 NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPH 495 Query: 179 ESLEKYIFSH--------------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRI 316 +L+ +++ + + ++ ++ A IARGM+YL ++R Sbjct: 496 GNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYL---ASRRC 552 Query: 317 LHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGV 496 +H D+ N+L+ ++ KI+DFGLA+ T R + ++APE F Sbjct: 553 IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKF--Y 610 Query: 497 SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVY 598 KSDV+S+G+L+ E+++ + P++ + +E+Y Sbjct: 611 DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELY 644
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 80.1 bits (196), Expect = 4e-15 Identities = 57/197 (28%), Positives = 101/197 (51%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+S + + EF++E + +G H N++ L G ++ ++ E+M N SL+ Sbjct: 666 VAIKTLKSGYTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDS 725 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ S +++ + GIA GM YL + +H D+ NIL++ N K Sbjct: 726 FLRQKEGQFSV-----LQLVGMLRGIAAGMRYLS---DMNYVHRDLAARNILVNSNLVCK 777 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ D S T T A G + + APE + + + SDV+S+G+++ E+ Sbjct: 778 VSDFGLSRFLEDDASNPTYTGALGCKIPIRWTAPE--AVQYRKFTSSSDVWSYGIVMWEV 835 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 836 MSYGERPYWDMSNQDVI 852
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 80.1 bits (196), Expect = 4e-15 Identities = 56/199 (28%), Positives = 106/199 (53%), Gaps = 5/199 (2%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L++ E + +F++E + +G H NI+RL G ++ +I E+M N +L Sbjct: 564 ISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGAL 623 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 624 DSFLRQNDGQFT-----VIQLVGMLRGIAAGMKYLSE---MNYVHRDLAARNILVNSNLV 675 Query: 368 PKISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 K+SDFGL++ D S T T++ G + + APE + + + SDV+S+G+++ Sbjct: 676 CKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE--AIRYRKFTSASDVWSYGIVMW 733 Query: 539 EMVSGRRNSDPSVENQDEV 595 E++S + NQD + Sbjct: 734 EVMSYGERPYWDMSNQDVI 752
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) Length = 813 Score = 80.1 bits (196), Expect = 4e-15 Identities = 58/194 (29%), Positives = 104/194 (53%), Gaps = 14/194 (7%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMP 175 + V VAVKML+ + E + + ++E+ + +I H NI+ L+G C++G +I EY Sbjct: 499 KESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAA 558 Query: 176 NESLEKYIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHF 325 +L +Y+ + V+ + + + ++ IARGMEYL +Q+ +H Sbjct: 559 KGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGMEYL---ASQKCIHR 615 Query: 326 DIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSY 502 D+ N+L+ N KI+DFGLA+ + R + ++APE L+ R + ++ Sbjct: 616 DLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVY---TH 672 Query: 503 KSDVYSFGMLVLEM 544 +SDV+SFG+L+ E+ Sbjct: 673 QSDVWSFGVLMWEI 686
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 80.1 bits (196), Expect = 4e-15 Identities = 55/181 (30%), Positives = 96/181 (53%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L +T +E ++E + + + ++ RL+G C T + LI + MP L Sbjct: 160 IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCL 218 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 YI H NI + L L+ + IA+GM YL + +R++H D+ N+L+ + Sbjct: 219 LDYIREHKDNIGSQYL-----LNWCVQIAKGMNYLEE---RRLVHRDLAARNVLVKTPQH 270 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLAKL D+ + + ++A E +++SDV+S+G+ V E++ Sbjct: 271 VKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRI--YTHQSDVWSYGVTVWELM 328 Query: 548 S 550 + Sbjct: 329 T 329
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 80.1 bits (196), Expect = 4e-15 Identities = 57/198 (28%), Positives = 104/198 (52%), Gaps = 4/198 (2%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 V VA+K L+ E + +F+ E + +G H N+V L G + G ++ E+M N +L Sbjct: 660 VAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGAL 719 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ H + +++ + GIA GM YL + +H D+ NIL++ N Sbjct: 720 DAFLRKHDGQFT-----VIQLVGMLRGIAAGMRYL---ADMGYVHRDLAARNILVNSNLV 771 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K+SDFGL+++ D +++ T T + + + APE + R F + SDV+S+G+++ E Sbjct: 772 CKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKF---TSASDVWSYGIVMWE 828 Query: 542 MVSGRRNSDPSVENQDEV 595 ++S + NQD + Sbjct: 829 VMSYGERPYWDMSNQDVI 846
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 80.1 bits (196), Expect = 4e-15 Identities = 63/190 (33%), Positives = 97/190 (51%), Gaps = 8/190 (4%) Frame = +2 Query: 14 VPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 V VAVK L T E + + E + + I+ ++G C+E ++ EYMPN Sbjct: 42 VRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNG 101 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL + + H + P + I IA G+ YLH N +LH D+K NILLD Sbjct: 102 SLNELL--HRKTEYPDIAWPLRFR-ILHEIALGVNYLHN-MNPPLLHHDLKTQNILLDNE 157 Query: 362 FNPKISDFGLAK--LCARDQSILTLTAAR-GTMGYIAPELYS-RNFGGVSYKSDVYSFGM 529 F+ KI+DFGL+K + + QS +A GT+ Y+ PE Y S K D+YS+ + Sbjct: 158 FHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAV 217 Query: 530 LVLEMVSGRR 559 ++ E++S ++ Sbjct: 218 IMWEVLSRKQ 227
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 80.1 bits (196), Expect = 4e-15 Identities = 55/181 (30%), Positives = 96/181 (53%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L +T +E ++E + + + ++ RL+G C T + LI + MP L Sbjct: 160 IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCL 218 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 YI H NI + L L+ + IA+GM YL + +R++H D+ N+L+ + Sbjct: 219 LDYIREHKDNIGSQYL-----LNWCVQIAKGMNYLEE---RRLVHRDLAARNVLVKTPQH 270 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLAKL D+ + + ++A E +++SDV+S+G+ V E++ Sbjct: 271 VKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRI--YTHQSDVWSYGVTVWELM 328 Query: 548 S 550 + Sbjct: 329 T 329
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 79.7 bits (195), Expect = 6e-15 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 10/194 (5%) Frame = +2 Query: 2 LRNGVPVAVKMLESS----TGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEY 169 L+ G VA+K+++ G E+ E++ + L+ H NIV L +E Sbjct: 32 LKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRHPNIVEL-------------HEV 78 Query: 170 MPNESLEKYIFSHVSN--ISQKLLAPTKMLDIALG----IARGMEYLHQGCNQRILHFDI 331 M +S ++ HV + K+ D+A + R +++ H ++ + H D+ Sbjct: 79 MATKSKIYFVMEHVKGGELFNKVSTGKLREDVARKYFQQLVRAVDFCH---SRGVCHRDL 135 Query: 332 KPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSD 511 KP N+LLD + N KISDFGL+ L + L GT Y+APE+ SRN G +K+D Sbjct: 136 KPENLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRN-GYDGFKAD 194 Query: 512 VYSFGMLVLEMVSG 553 V+S G+++ +++G Sbjct: 195 VWSCGVILFVLLAG 208
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 79.7 bits (195), Expect = 6e-15 Identities = 59/190 (31%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE +I EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 460 VPYPGMVNRE 469
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 79.7 bits (195), Expect = 6e-15 Identities = 59/190 (31%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE +I EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 460 VPYPGMVNRE 469
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 79.7 bits (195), Expect = 6e-15 Identities = 57/182 (31%), Positives = 101/182 (55%), Gaps = 4/182 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVK+L+ S E+ F NE+ + H NI+ MGF + A+I ++ SL Sbjct: 333 VAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLY 391 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ HV++ ++ +++D+A A+GM+YLH + I+H D+K +NI L Sbjct: 392 HHL--HVADTRFDMV---QLIDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTV 443 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + R L G++ ++A E + ++ S++SDVY++G+++ E++ Sbjct: 444 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 503 Query: 548 SG 553 +G Sbjct: 504 TG 505
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 79.7 bits (195), Expect = 6e-15 Identities = 56/197 (28%), Positives = 105/197 (53%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L++ E + +F++E + +G H NI+RL G ++ +I E+M N +L+ Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL + +H D+ NIL++ N K Sbjct: 708 FLRQNDGQFT-----VIQLVGMLRGIAAGMKYLSE---MNYVHRDLAARNILVNSNLVCK 759 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ D S T T++ G + + APE + + + SDV+S+G+++ E+ Sbjct: 760 VSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA--YRKFTSASDVWSYGIVMWEV 817 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 818 MSFGERPYWDMSNQDVI 834
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 79.3 bits (194), Expect = 8e-15 Identities = 58/190 (30%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 460 VPYPGMVNRE 469
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 79.3 bits (194), Expect = 8e-15 Identities = 55/197 (27%), Positives = 101/197 (51%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+ E + EF++E + +G H NI+RL G + ++ E+M N +L+ Sbjct: 644 VAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDS 703 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ ++ +++ + GIA GM YL +H D+ NIL++ N K Sbjct: 704 FL-----RLNDGQFTVIQLVGMLRGIASGMRYL---AEMSYVHRDLAARNILVNSNLVCK 755 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ + S T T++ G ++ + APE + F + SD +S+G+++ E+ Sbjct: 756 VSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAIA--FRKFTSASDAWSYGIVMWEV 813 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 814 MSFGERPYWDMSNQDVI 830
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 79.3 bits (194), Expect = 8e-15 Identities = 59/190 (31%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 295 VAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 353 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L ++D+A +A GM Y+ + +H D++ NIL+ N KI+ Sbjct: 354 ----KDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGDNLVCKIA 406 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 407 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTKGR 463 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 464 VPYPGMNNRE 473
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 79.3 bits (194), Expect = 8e-15 Identities = 58/190 (30%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 460 VPYPGMVNRE 469
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 79.3 bits (194), Expect = 8e-15 Identities = 60/190 (31%), Positives = 98/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T E F+ E + + H +V+L SE ++ E+M SL ++ Sbjct: 294 VAVKTLKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVSEEPIY-IVTEFMSQGSLLDFL 352 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L +++D+A IA GM Y+ + +H D++ NIL+ N KI+ Sbjct: 353 ----KDGDGRYLKLPQLVDMAAQIAAGMAYIER---MNYIHRDLRAANILVGDNLVCKIA 405 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + FG + KSDV+SFG+L+ E+V+ R Sbjct: 406 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALFGKFTIKSDVWSFGILLTELVTKGR 462 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 463 VPYPGMNNRE 472
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 79.3 bits (194), Expect = 8e-15 Identities = 56/197 (28%), Positives = 104/197 (52%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L++ E + +F++E + +G H NI+RL G ++ +I E+M N +L+ Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL +H D+ NIL++ N K Sbjct: 708 FLRQNDGQFT-----VIQLVGMLRGIAAGMKYL---AEMNYVHRDLAARNILVNSNLVCK 759 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ D S T T++ G + + APE + + + SDV+S+G+++ E+ Sbjct: 760 VSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA--YRKFTSASDVWSYGIVMWEV 817 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 818 MSFGERPYWDMSNQDVI 834
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 79.3 bits (194), Expect = 8e-15 Identities = 56/197 (28%), Positives = 104/197 (52%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L++ E + +F++E + +G H NI+RL G ++ +I E+M N +L+ Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL +H D+ NIL++ N K Sbjct: 708 FLRQNDGQFT-----VIQLVGMLRGIAAGMKYL---AEMNYVHRDLAARNILVNSNLVCK 759 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ D S T T++ G + + APE + + + SDV+S+G+++ E+ Sbjct: 760 VSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA--YRKFTSASDVWSYGIVMWEV 817 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 818 MSFGERPYWDMSNQDVI 834
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 79.3 bits (194), Expect = 8e-15 Identities = 58/190 (30%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 460 VPYPGMVNRE 469
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 79.3 bits (194), Expect = 8e-15 Identities = 56/197 (28%), Positives = 103/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L+ E + +F+ E + +G H NI+ L G ++ ++ EYM N SL Sbjct: 541 LPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSL 600 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 601 DTFLKKNDGQFT-----VIQLVGMLRGIAAGMKYL---SDMGYVHRDLAARNILINSNLV 652 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + APE + F + SDV+S+G+++ E+ Sbjct: 653 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA--FRKFTSASDVWSYGIVMWEV 710 Query: 545 VSGRRNSDPSVENQDEV 595 VS + NQD + Sbjct: 711 VSYGERPYWEMTNQDVI 727
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 79.3 bits (194), Expect = 8e-15 Identities = 54/197 (27%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L+ E + +F+ E + +G H NI+RL G ++ ++ EYM N SL Sbjct: 648 ISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSL 707 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ H + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 708 DSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLV 759 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + +PE + + + SDV+S+G+++ E+ Sbjct: 760 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA--YRKFTSASDVWSYGIVLWEV 817 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 818 MSYGERPYWEMSNQDVI 834
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 79.0 bits (193), Expect = 1e-14 Identities = 58/198 (29%), Positives = 105/198 (53%), Gaps = 6/198 (3%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+S E + +F++E + +G H N++ L G ++ + +I E+M N SL+ Sbjct: 651 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDS 710 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ + GIA GM+YL + +H D+ N L++ N K Sbjct: 711 FLRQNDGQFT-----VIQLVGMLRGIAAGMKYL---ADMNYVHRDLAARNTLVNSNLVCK 762 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 +SDFGL++ D S T T+A G + + APE + R F + SDV+S+G+++ E Sbjct: 763 VSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKF---TSASDVWSYGIVMWE 819 Query: 542 MVSGRRNSDPSVENQDEV 595 ++S + NQD + Sbjct: 820 VMSYGERPYWDMTNQDVI 837
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 79.0 bits (193), Expect = 1e-14 Identities = 58/190 (30%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 295 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 353 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L ++D+A +ARGM Y+ + +H D++ NIL+ KI+ Sbjct: 354 ----KDGEGRALKLPNLVDMAAQVARGMAYIER---MNYIHRDLRSANILVGNGLICKIA 406 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 407 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTKGR 463 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 464 VPYPGMNNRE 473
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 79.0 bits (193), Expect = 1e-14 Identities = 57/202 (28%), Positives = 106/202 (52%), Gaps = 5/202 (2%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 R V VA+K L+ E + +F++E + +G H NI+RL G ++ ++ E+M N Sbjct: 657 RREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMEN 716 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ ++ +++ + GIA GM+YL + +H D+ NIL++ Sbjct: 717 CALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKYLSE---MNYVHRDLAARNILVNS 768 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGM 529 N K+SDFGL++ D S T T++ G + + APE + + + SDV+S+G+ Sbjct: 769 NLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA--YRKFTSASDVWSYGI 826 Query: 530 LVLEMVSGRRNSDPSVENQDEV 595 ++ E++S + NQD + Sbjct: 827 VMWEVMSYGERPYWDMSNQDVI 848
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 79.0 bits (193), Expect = 1e-14 Identities = 58/190 (30%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 294 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 352 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 353 KGETG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 405 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 406 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 462 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 463 VPYPGMVNRE 472
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/197 (27%), Positives = 104/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L+ E + +F+ E + +G H NI+RL G ++ ++ EYM N SL Sbjct: 649 ISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSL 708 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ H + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 709 DSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLV 760 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + +PE + + + SDV+S+G+++ E+ Sbjct: 761 CKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPE--ATAYRKFTSASDVWSYGIVLWEV 818 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 819 MSYGERPYWEMSNQDVI 835
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 79.0 bits (193), Expect = 1e-14 Identities = 57/202 (28%), Positives = 106/202 (52%), Gaps = 5/202 (2%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 R V VA+K L+ E + +F++E + +G H NI+RL G ++ ++ E+M N Sbjct: 652 RREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMEN 711 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ ++ +++ + GIA GM+YL + +H D+ NIL++ Sbjct: 712 CALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKYLSE---MNYVHRDLAARNILVNS 763 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGM 529 N K+SDFGL++ D S T T++ G + + APE + + + SDV+S+G+ Sbjct: 764 NLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA--YRKFTSASDVWSYGI 821 Query: 530 LVLEMVSGRRNSDPSVENQDEV 595 ++ E++S + NQD + Sbjct: 822 VMWEVMSYGERPYWDMSNQDVI 843
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/200 (27%), Positives = 104/200 (52%), Gaps = 5/200 (2%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 R VA+K L++ E + +F++E + +G H N++ L G + ++ E+M N Sbjct: 211 RKETTVAIKTLKAGYTEHQRRDFLSEASIMGQFDHPNVIHLEGVLTRSCPVLIVTEFMEN 270 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ ++ T+++ + GIA GM+YL + +H D+ N+L++ Sbjct: 271 GALDSFL-----RLNDGRFTVTQLVGMLRGIAAGMKYLS---DMNYVHRDLAARNVLVNS 322 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGM 529 N K+SDFGL++ + S T T++ G + + APE + F + SDV+S+G+ Sbjct: 323 NLVCKVSDFGLSRFLDDNSSDPTYTSSLGGKIPIRWTAPEAIA--FRKFTSASDVWSYGI 380 Query: 530 LVLEMVSGRRNSDPSVENQD 589 ++ E++S + NQD Sbjct: 381 VMWEVMSFGERPYWDMSNQD 400
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 78.6 bits (192), Expect = 1e-14 Identities = 62/184 (33%), Positives = 95/184 (51%), Gaps = 3/184 (1%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG---EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 G+ VA+K L+ E E FI EV + +H NIV +G C + +I EYM Sbjct: 129 GIHVAIKKLKIIGDEEQFKERFIREVQNLKKGNHQNIVMFIGACYKPA--CIITEYMAGG 186 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL + + S+ + + +L +A +A G+ +LH + I+H D+ NILLD Sbjct: 187 SLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLH---SITIVHRDLTSQNILLDEL 243 Query: 362 FNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLE 541 N KISDFGL+ +R+ S+ + PEL ++N G S K DVY F ++V E Sbjct: 244 GNIKISDFGLSAEKSREGSMTMTNGGICNPRWRPPEL-TKNLGHYSEKVDVYCFSLVVWE 302 Query: 542 MVSG 553 +++G Sbjct: 303 ILTG 306
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 78.6 bits (192), Expect = 1e-14 Identities = 59/188 (31%), Positives = 95/188 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE +I EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHKKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVEN 583 P + N Sbjct: 460 VPYPGMGN 467
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 78.6 bits (192), Expect = 1e-14 Identities = 55/173 (31%), Positives = 88/173 (50%), Gaps = 8/173 (4%) Frame = +2 Query: 59 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 E+ E G + H NI+ L G C L+ EY +L + + + + + Sbjct: 140 EQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-------AGRRVP 192 Query: 239 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILL-----DYNFNP---KISDFGLA 394 P +++ A+ +ARGM YLH I+H D+K NIL+ ++N KI+DFGL Sbjct: 193 PHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGL- 251 Query: 395 KLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 AR+ T +A GT ++APE+ + S SDV+SFG+L+ E+++G Sbjct: 252 ---AREWHKTTKMSAAGTYAWMAPEVIRLSL--FSKSSDVWSFGVLLWELLTG 299
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/182 (30%), Positives = 101/182 (55%), Gaps = 4/182 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVK+L+ + E+ F NE+ + H NI+ MGF + A+I ++ SL Sbjct: 333 VAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLY 391 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ HV++ ++ +++D+A A+GM+YLH + I+H D+K +NI L Sbjct: 392 HHL--HVADTRFDMV---QLIDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTV 443 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + R L G++ ++A E + ++ S++SDVY++G+++ E++ Sbjct: 444 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 503 Query: 548 SG 553 +G Sbjct: 504 TG 505
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/197 (28%), Positives = 103/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA K L+ E + +F++E + +G H NI+ L G ++ ++ EYM N SL Sbjct: 704 LPVATKTLKVGYTEKQRRDFLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSL 763 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 764 DTFLKKNDGQFT-----VIQLVGMLRGIAAGMKYL---SDMGYVHRDLAARNILINSNLV 815 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + APE + F + SDV+S+G+++ E+ Sbjct: 816 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA--FRKFTSASDVWSYGIVMWEV 873 Query: 545 VSGRRNSDPSVENQDEV 595 VS + NQD + Sbjct: 874 VSYGERPYWEMTNQDVI 890
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/182 (30%), Positives = 101/182 (55%), Gaps = 4/182 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVK+L+ + E+ F NE+ + H NI+ MGF + A+I ++ SL Sbjct: 331 VAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLY 389 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ HV++ ++ +++D+A A+GM+YLH + I+H D+K +NI L Sbjct: 390 HHL--HVADTRFDMV---QLIDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTV 441 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + R L G++ ++A E + ++ S++SDVY++G+++ E++ Sbjct: 442 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 501 Query: 548 SG 553 +G Sbjct: 502 TG 503
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/182 (30%), Positives = 101/182 (55%), Gaps = 4/182 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEE---FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVK+L+ + E+ F NE+ + H NI+ MGF + A+I ++ SL Sbjct: 331 VAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLY 389 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ HV++ ++ +++D+A A+GM+YLH + I+H D+K +NI L Sbjct: 390 HHL--HVADTRFDMV---QLIDVARQTAQGMDYLHA---KNIIHRDLKSNNIFLHEGLTV 441 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI DFGLA + R L G++ ++A E + ++ S++SDVY++G+++ E++ Sbjct: 442 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 501 Query: 548 SG 553 +G Sbjct: 502 TG 503
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 78.6 bits (192), Expect = 1e-14 Identities = 59/188 (31%), Positives = 95/188 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE +I EYM SL ++ Sbjct: 288 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAMVSEEPIYIVI-EYMSKGSLLDFL 346 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++++A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 347 KGEMG----KYLRLPQLVEMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 399 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D AR + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 400 DFGLARL-IEDNEYTARPGARFPVKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 456 Query: 560 NSDPSVEN 583 P + N Sbjct: 457 VPYPGMVN 464
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 78.6 bits (192), Expect = 1e-14 Identities = 62/190 (32%), Positives = 97/190 (51%), Gaps = 8/190 (4%) Frame = +2 Query: 14 VPVAVKMLESST----GEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 V VAVK L T E ++ + E + + I+ ++G C+E ++ EYMPN Sbjct: 42 VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNG 101 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL + + H + P + I IA G+ YLH +LH D+K NILLD Sbjct: 102 SLNELL--HRKTEYPDVAWPLRFR-ILHEIALGVNYLHN-MTPPLLHHDLKTQNILLDNE 157 Query: 362 FNPKISDFGLAK--LCARDQSILTLTAAR-GTMGYIAPELYS-RNFGGVSYKSDVYSFGM 529 F+ KI+DFGL+K + + QS + +A GT+ Y+ PE Y S K D+YS+ + Sbjct: 158 FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAV 217 Query: 530 LVLEMVSGRR 559 + E++S ++ Sbjct: 218 ITWEVLSRKQ 227
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 78.6 bits (192), Expect = 1e-14 Identities = 54/179 (30%), Positives = 96/179 (53%), Gaps = 2/179 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+KM+ + +EFI+E + + H +V+L G C++ +I EYM N L ++ Sbjct: 425 VAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNFL 484 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 +Q+ P ++L++ + MEYL +++ LH D+ N L++ K+S Sbjct: 485 -----RETQRRFQPAELLEMCKDVCEAMEYLE---SKQFLHRDLAARNCLVNDQGIVKVS 536 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPE--LYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGL++ D+ ++ ++ + + PE LYS+ S KSDV+SFG+L+ E+ S Sbjct: 537 DFGLSRYVLDDEYTSSM-GSKFPVRWSPPEVLLYSK----FSSKSDVWSFGVLMWEVYS 590
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 78.2 bits (191), Expect = 2e-14 Identities = 59/189 (31%), Positives = 101/189 (53%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 G VAVK ++ + F++E A + + H N+VRL+G ++ E++ +L Sbjct: 215 GQKVAVKNIKCDV-TAQAFLDETAVMTKLQHRNLVRLLGVILHHGLY-IVMEHVSKGNLV 272 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ + + L++ +++L AL +A GMEYL +++++H D+ NIL+ + Sbjct: 273 NFLRTR----GRALVSTSQLLQFALHVAEGMEYLE---SKKLVHRDLAARNILVSEDLVA 325 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 K+SDFGLAK R L ++R + + APE G S KSDV+SFG+L+ E+ S Sbjct: 326 KVSDFGLAKAELRK----GLDSSRLPVKWTAPEALKN--GRFSSKSDVWSFGVLLWEVFS 379 Query: 551 GRRNSDPSV 577 R P + Sbjct: 380 YGRAPYPKM 388
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 78.2 bits (191), Expect = 2e-14 Identities = 55/197 (27%), Positives = 103/197 (52%), Gaps = 3/197 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L+ E + +F+ E + +G H NI+ L G ++ ++ EYM N SL Sbjct: 702 LPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSL 761 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ + + +++ + GI+ GM+YL + +H D+ NIL++ N Sbjct: 762 DTFLKKNDGQFT-----VIQLVGMLRGISAGMKYL---SDMGYVHRDLAARNILINSNLV 813 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + APE + F + SDV+S+G+++ E+ Sbjct: 814 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA--FRKFTSASDVWSYGIVMWEV 871 Query: 545 VSGRRNSDPSVENQDEV 595 VS + NQD + Sbjct: 872 VSYGERPYWEMTNQDVI 888
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 78.2 bits (191), Expect = 2e-14 Identities = 56/185 (30%), Positives = 101/185 (54%), Gaps = 5/185 (2%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSE--GTRRALIYEYMPN 178 G VAVK L+ +G + E+ + ++H NIV+ G C+E G LI E++P+ Sbjct: 890 GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS 949 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL++Y+ + + I+ K + L A+ I +GM+YL +++ +H D+ N+L++ Sbjct: 950 GSLKEYLPKNKNKINLK-----QQLKYAVQICKGMDYLG---SRQYVHRDLAARNVLVES 1001 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGT-MGYIAPELYSRNFGGVSYKSDVYSFGMLV 535 KI DFGL K D+ T+ R + + + APE ++ ++ SDV+SFG+ + Sbjct: 1002 EHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIA--SDVWSFGVTL 1059 Query: 536 LEMVS 550 E+++ Sbjct: 1060 HELLT 1064
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 78.2 bits (191), Expect = 2e-14 Identities = 55/197 (27%), Positives = 100/197 (50%), Gaps = 5/197 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+ E + EF++E + +G H NI+RL G + ++ E+M N +L+ Sbjct: 644 VAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDS 703 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ ++ +++ + GIA GM YL +H D+ NIL++ N K Sbjct: 704 FL-----RLNDGQFTVIQLVGMLRGIASGMRYL---AEMSYVHRDLAARNILVNSNLVCK 755 Query: 374 ISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 +SDFGL++ + S T T++ G + + APE + F + SD +S+G+++ E+ Sbjct: 756 VSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIA--FRKFTSASDAWSYGIVMWEV 813 Query: 545 VSGRRNSDPSVENQDEV 595 +S + NQD + Sbjct: 814 MSFGERPYWDMSNQDVI 830
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 78.2 bits (191), Expect = 2e-14 Identities = 63/192 (32%), Positives = 101/192 (52%), Gaps = 9/192 (4%) Frame = +2 Query: 11 GVPVAVKMLE----SSTGEG-----EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIY 163 G +AVK +E SS E E +EV+T+ + H NIV+ +GF ++ +L Sbjct: 1198 GEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFL 1257 Query: 164 EYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHN 343 EY+ S+ I + + L+ + + +G+ YLH ++ ILH D+K N Sbjct: 1258 EYVAGGSVGSLIRMY-GRFDEPLIK-----HLTTQVLKGLAYLH---SKGILHRDMKADN 1308 Query: 344 ILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSF 523 +LLD + KISDFG+++ S +T RGT+ ++APE+ G S K D++S Sbjct: 1309 LLLDQDGICKISDFGISRKSKDIYSNSDMT-MRGTVFWMAPEMVDTK-QGYSAKVDIWSL 1366 Query: 524 GMLVLEMVSGRR 559 G +VLEM +G+R Sbjct: 1367 GCIVLEMFAGKR 1378
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 78.2 bits (191), Expect = 2e-14 Identities = 58/188 (30%), Positives = 95/188 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVEN 583 P + N Sbjct: 460 VPYPGMGN 467
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 78.2 bits (191), Expect = 2e-14 Identities = 58/188 (30%), Positives = 95/188 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 291 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 349 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 350 KGEMG----KYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 403 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 459 Query: 560 NSDPSVEN 583 P + N Sbjct: 460 VPYPGMGN 467
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 78.2 bits (191), Expect = 2e-14 Identities = 57/190 (30%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 290 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 348 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 349 KGEMG----RYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 401 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 402 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 458 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 459 VPYPGMVNRE 468
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 77.8 bits (190), Expect = 2e-14 Identities = 60/200 (30%), Positives = 109/200 (54%), Gaps = 14/200 (7%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML+S E + + I+E+ + +I H NI+ L+G C++ +I EY +L Sbjct: 511 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 570 Query: 191 KYIFS----------HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPH 340 +Y+ + + S+ ++ L+ ++ A +ARGMEYL +++ +H D+ Sbjct: 571 EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL---ASKKCIHRDLAAR 627 Query: 341 NILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVY 517 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SDV+ Sbjct: 628 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY---THQSDVW 684 Query: 518 SFGMLVLEMVSGRRNSDPSV 577 SFG+L+ E+ + + +P V Sbjct: 685 SFGVLLWEIFTLGGSPNPGV 704
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 77.8 bits (190), Expect = 2e-14 Identities = 51/180 (28%), Positives = 91/180 (50%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 R+ + VA+K + + E+FI E + + H+ +V+L G C + ++ E+M N Sbjct: 291 RSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGC 350 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L Y+ + + +++L L + I GMEYL + +H D+ N L+ Sbjct: 351 LLNYLRENKGKLRKEML-----LSVCQDICEGMEYLER---NGYIHRDLAARNCLVSSTC 402 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 KISDFG+ + D+ + + A+ + + PE++ F S KSDV+SFG+L+ E+ Sbjct: 403 IVKISDFGMTRYVLDDEYVSSF-GAKFPIKWSPPEVFL--FNKYSSKSDVWSFGVLMWEV 459
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 5/199 (2%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L++ E + +F++E + +G H NI+RL G ++ +I E+M N +L Sbjct: 647 ISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGAL 706 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 707 DSFLRQNDGQFT-----VIQLVGMLRGIAAGMKYLSE---MNYVHRDLAARNILVNSNLV 758 Query: 368 PKISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 K+SDFGL++ D S T T++ G + + A E + + + SDV+S+G+++ Sbjct: 759 CKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAQEAIA--YRKFTSASDVWSYGIVMW 816 Query: 539 EMVSGRRNSDPSVENQDEV 595 E++S ++ NQD + Sbjct: 817 EVMSYGERPYWTMSNQDVI 835
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 77.8 bits (190), Expect = 2e-14 Identities = 53/181 (29%), Positives = 96/181 (53%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L +T +E ++E + + + ++ RL+G C T + LI + MP L Sbjct: 742 IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCL 800 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 Y+ H NI + L L+ + IA+GM YL ++R++H D+ N+L+ + Sbjct: 801 LDYVREHKDNIGSQYL-----LNWCVQIAKGMNYLE---DRRLVHRDLAARNVLVKTPQH 852 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLAKL ++ + + ++A E +++SDV+S+G+ V E++ Sbjct: 853 VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRI--YTHQSDVWSYGVTVWELM 910 Query: 548 S 550 + Sbjct: 911 T 911
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 77.8 bits (190), Expect = 2e-14 Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 14/194 (7%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMP 175 + V VAVKML+ E + + ++E+ + +I H NI+ L+G C++ +I EY Sbjct: 511 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 570 Query: 176 NESLEKYIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHF 325 +L +Y+ + ++ + ++ + ++ +ARGMEYL +Q+ +H Sbjct: 571 KGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQLARGMEYL---ASQKCIHR 627 Query: 326 DIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSY 502 D+ N+L+ N KI+DFGLA+ T R + ++APE L+ R + ++ Sbjct: 628 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVY---TH 684 Query: 503 KSDVYSFGMLVLEM 544 +SDV+SFG+L+ E+ Sbjct: 685 QSDVWSFGVLMWEI 698
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/196 (28%), Positives = 102/196 (52%), Gaps = 3/196 (1%) Frame = +2 Query: 17 PVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 PVA+K L+ E + +F+ E + +G H NI+ L G ++ ++ EYM N SL+ Sbjct: 679 PVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLD 738 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 739 TFLKKNDGQFT-----VIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVC 790 Query: 371 KISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K+SDFGL+++ D ++ T + + + APE + F + SDV+S+G+++ E++ Sbjct: 791 KVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA--FRKFTSASDVWSYGIVMWEVM 848 Query: 548 SGRRNSDPSVENQDEV 595 S + NQD + Sbjct: 849 SYGERPYWEMTNQDVI 864
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 77.8 bits (190), Expect = 2e-14 Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 14/194 (7%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMP 175 + V VAVKML+ E + + ++E+ + +I H NI+ L+G C++ +I EY Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568 Query: 176 NESLEKYIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHF 325 +L +Y+ + ++ + ++ + ++ +ARGMEYL +Q+ +H Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYL---ASQKCIHR 625 Query: 326 DIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSY 502 D+ N+L+ N KI+DFGLA+ T R + ++APE L+ R + ++ Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVY---TH 682 Query: 503 KSDVYSFGMLVLEM 544 +SDV+SFG+L+ E+ Sbjct: 683 QSDVWSFGVLMWEI 696
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 77.8 bits (190), Expect = 2e-14 Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 14/194 (7%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMP 175 + V VAVKML+ E + + ++E+ + +I H NI+ L+G C++ +I EY Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568 Query: 176 NESLEKYIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHF 325 +L +Y+ + ++ + ++ + ++ +ARGMEYL +Q+ +H Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYL---ASQKCIHR 625 Query: 326 DIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSY 502 D+ N+L+ N KI+DFGLA+ T R + ++APE L+ R + ++ Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVY---TH 682 Query: 503 KSDVYSFGMLVLEM 544 +SDV+SFG+L+ E+ Sbjct: 683 QSDVWSFGVLMWEI 696
>EGFR_HUMAN (P00533) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Receptor tyrosine-protein kinase ErbB-1) Length = 1210 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/181 (29%), Positives = 96/181 (53%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L +T +E ++E + + + ++ RL+G C T + LI + MP L Sbjct: 740 IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCL 798 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 Y+ H NI + L L+ + IA+GM YL ++R++H D+ N+L+ + Sbjct: 799 LDYVREHKDNIGSQYL-----LNWCVQIAKGMNYLE---DRRLVHRDLAARNVLVKTPQH 850 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLAKL ++ + + ++A E +++SDV+S+G+ V E++ Sbjct: 851 VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRI--YTHQSDVWSYGVTVWELM 908 Query: 548 S 550 + Sbjct: 909 T 909
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 77.4 bits (189), Expect = 3e-14 Identities = 58/189 (30%), Positives = 101/189 (53%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 G VAVK ++ + F++E A + + H N+VRL+G ++ E++ +L Sbjct: 254 GQKVAVKNIKCDV-TAQAFLDETAVMTKLQHRNLVRLLGVILHHGLY-IVMEHVSKGNLV 311 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 ++ + + L++ +++L AL +A GMEYL +++++H D+ NIL+ + Sbjct: 312 NFLRTR----GRALVSTSQLLQFALHVAEGMEYLE---SKKLVHRDLAARNILVSEDLVA 364 Query: 371 KISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 550 K+SDFGLAK + L ++R + + APE G S KSDV+SFG+L+ E+ S Sbjct: 365 KVSDFGLAKAERKG-----LDSSRLPVKWTAPEALKN--GRFSSKSDVWSFGVLLWEVFS 417 Query: 551 GRRNSDPSV 577 R P + Sbjct: 418 YGRAPYPKM 426
>FGFR2_DROME (Q09147) Fibroblast growth factor receptor homolog 2 precursor (EC| 2.7.10.1) (Protein breathless) (dFGF-R1) Length = 1052 Score = 77.4 bits (189), Expect = 3e-14 Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 21/214 (9%) Frame = +2 Query: 20 VAVKML--ESSTGEGEEFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKM+ E + + + E+ + +I H NI+ L+G CS+G +I EY P+ +L+ Sbjct: 745 VAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLK 804 Query: 191 KYIFSHVSN-----------------ISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 319 ++ + IS + L ++ A IARGMEYL ++R + Sbjct: 805 DFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYL---ASRRCI 861 Query: 320 HFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGV 496 H D+ N+L+ + KI+DFGLA+ + T R + ++APE L + + Sbjct: 862 HRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDS- 920 Query: 497 SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVY 598 +SDV+S+G+L+ E+++ P + + +E+Y Sbjct: 921 --QSDVWSYGVLLWEIMTYGDQPYPHILSAEELY 952
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 77.4 bits (189), Expect = 3e-14 Identities = 57/190 (30%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 299 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFL 357 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D++ IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 358 KGETG----KYLRLPQLVDMSAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 410 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 411 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 467 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 468 VPYPGMVNRE 477
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 77.0 bits (188), Expect = 4e-14 Identities = 56/197 (28%), Positives = 102/197 (51%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 +N + VA+K L+ T E F+ E + + H +VRL ++ ++ EYM Sbjct: 260 KNNMKVAIKTLKEGTMSPEAFLGEANMMKALQHERLVRLYAVVTKEPIY-IVTEYMARGC 318 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L ++ ++ +L P +++D++ IA GM Y+ + +H D++ NIL+ Sbjct: 319 LLDFL---KTDEGSRLSLP-RLIDMSAQIAEGMAYIER---MNSIHRDLRAANILVSEAL 371 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 KI+DFGLA++ D A+ + + APE +FG + K+DV+SFG+L++E+ Sbjct: 372 CCKIADFGLARII--DSEYTAQEGAKFPIKWTAPEAI--HFGVFTIKADVWSFGVLLMEV 427 Query: 545 VSGRRNSDPSVENQDEV 595 V+ R P + N + + Sbjct: 428 VTYGRVPYPGMSNPEVI 444
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 77.0 bits (188), Expect = 4e-14 Identities = 57/190 (30%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 294 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFL 352 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D++ IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 353 KGETG----KYLRLPQLVDMSAQIASGMAYVDR---MNYVHRDLRAANILVGENLVCKVA 405 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 406 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 462 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 463 VPYPGMVNRE 472
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 76.6 bits (187), Expect = 5e-14 Identities = 49/162 (30%), Positives = 89/162 (54%) Frame = +2 Query: 74 EVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKML 253 E++ I + H NIV+ +GF T ++ EY+ S+ + + ++ Q + ++ Sbjct: 880 EISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQ- 938 Query: 254 DIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLT 433 + G+ YLH ++ I+H D+K N+L+D++ KISDFG++K Sbjct: 939 -----VLYGLSYLH---SKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANL 990 Query: 434 AARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 + +G++ ++APE+ + G S K DV+S G +VLEM++GRR Sbjct: 991 SMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRR 1032
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 76.6 bits (187), Expect = 5e-14 Identities = 52/173 (30%), Positives = 87/173 (50%) Frame = +2 Query: 38 ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSN 217 E + G E EV + + H NIVR +G E ++ E++P S+ + S Sbjct: 109 EKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSF 168 Query: 218 ISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK 397 ++ TK L + G+EYLH N I+H DIK NIL+D +++DFG +K Sbjct: 169 PEPVIIMYTKQLLL------GLEYLH---NNGIMHRDIKGANILVDNKGCIRLADFGASK 219 Query: 398 LCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 556 ++ + +GT ++APE+ + G S+ +D++S G V+EM +G+ Sbjct: 220 KVVELATVNGAKSMKGTPYWMAPEVILQT--GHSFSADIWSVGCTVIEMATGK 270
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 76.6 bits (187), Expect = 5e-14 Identities = 57/190 (30%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 292 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL 350 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L ++D+A +A GM Y+ + +H D++ NIL+ KI+ Sbjct: 351 ----KDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGNGLICKIA 403 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 404 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTKGR 460 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 461 VPYPGMNNRE 470
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 76.6 bits (187), Expect = 5e-14 Identities = 60/190 (31%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V L SE ++ EYM SL ++ Sbjct: 295 VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEYMIKGSLLDFL 353 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + K L +++D+A IA GM Y+ + +H D++ NIL+ N KI+ Sbjct: 354 ----KEGNGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGDNLVCKIA 406 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 407 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVAKGR 463 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 464 VPYPGMVNRE 473
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 76.6 bits (187), Expect = 5e-14 Identities = 57/192 (29%), Positives = 100/192 (52%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK ++ + E F+ E + + H +V+L S+ ++ E+M SL ++ Sbjct: 263 VAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQEPI-FIVTEFMAKGSLLDFL 321 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S + Q L K++D + I+ GM ++ Q + +H D++ NIL+ + KI+ Sbjct: 322 KSEEGS-KQPL---PKLIDFSAQISEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIA 374 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA++ D A+ + + APE NFG + KSDV+SFG+L++E+V+ R Sbjct: 375 DFGLARII-EDNEYTAREGAKFPIKWTAPEAI--NFGSFTIKSDVWSFGILLMEIVTYGR 431 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 432 IPYPGMSNPEVI 443
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 76.6 bits (187), Expect = 5e-14 Identities = 61/193 (31%), Positives = 91/193 (47%), Gaps = 5/193 (2%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCS-----EGTRRALIYEYMP 175 G VAVK++ S EV + + + ++RL G + + AL+ ++M Sbjct: 44 GYDVAVKIVNSKA-----ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFME 98 Query: 176 NESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLD 355 N SL + S L K + GM YLH N +LH D+KP N+L D Sbjct: 99 NGSLSGLLQSQCPRPWPLLCRLLKE------VVLGMFYLHDQ-NPVLLHRDLKPSNVLPD 151 Query: 356 YNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLV 535 + K++DFGL+ QS GT+GY+APEL+ S SDVYSFG+L+ Sbjct: 152 PELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILM 211 Query: 536 LEMVSGRRNSDPS 574 +++GR P+ Sbjct: 212 WAVLAGREVELPT 224
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 76.6 bits (187), Expect = 5e-14 Identities = 56/190 (29%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EY+ SL ++ Sbjct: 290 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYISKGSLLDFL 348 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L +++D+A IA GM Y+ + +H D++ NIL+ N K++ Sbjct: 349 KGEMG----RYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 401 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+ + R Sbjct: 402 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELTTKGR 458 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 459 VPYPGMVNRE 468
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 76.6 bits (187), Expect = 5e-14 Identities = 50/182 (27%), Positives = 99/182 (54%), Gaps = 3/182 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 + VA+K L++ E + +F+ E + +G H NI+RL G ++ ++ EYM N SL Sbjct: 648 ISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSL 707 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 + ++ H + + +++ + GIA GM+YL + +H D+ NIL++ N Sbjct: 708 DSFLRKHDAQFT-----VIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLV 759 Query: 368 PKISDFGLAKLCARD-QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K+SDFGL+++ D ++ T + + + +PE + + + SD +S+G+++ E+ Sbjct: 760 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA--YRKFTSASDAWSYGIVLWEV 817 Query: 545 VS 550 +S Sbjct: 818 MS 819
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 76.3 bits (186), Expect = 6e-14 Identities = 58/189 (30%), Positives = 104/189 (55%), Gaps = 14/189 (7%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML+S E + + I+E+ + +I H NI+ L+G C++ +I EY +L Sbjct: 511 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 570 Query: 191 KYIFS----------HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPH 340 +Y+ + + S+ ++ L+ ++ A +ARGMEYL +++ +H D+ Sbjct: 571 EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL---ASKKCIHRDLAAR 627 Query: 341 NILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVY 517 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SDV+ Sbjct: 628 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY---THQSDVW 684 Query: 518 SFGMLVLEM 544 SFG+L+ E+ Sbjct: 685 SFGVLLWEI 693
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 76.3 bits (186), Expect = 6e-14 Identities = 58/189 (30%), Positives = 104/189 (55%), Gaps = 14/189 (7%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML+S E + + I+E+ + +I H NI+ L+G C++ +I EY +L Sbjct: 511 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 570 Query: 191 KYIFS----------HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPH 340 +Y+ + + S+ ++ L+ ++ A +ARGMEYL +++ +H D+ Sbjct: 571 EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL---ASKKCIHRDLAAR 627 Query: 341 NILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVY 517 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SDV+ Sbjct: 628 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY---THQSDVW 684 Query: 518 SFGMLVLEM 544 SFG+L+ E+ Sbjct: 685 SFGVLLWEI 693
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 76.3 bits (186), Expect = 6e-14 Identities = 59/204 (28%), Positives = 110/204 (53%), Gaps = 14/204 (6%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML+S E + + I+E+ + +I H NI+ L+G C++ +I EY +L Sbjct: 505 VAVKMLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGNLR 564 Query: 191 KYIFS----------HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPH 340 +Y+ + + + + +LL+ ++ A +ARGM+YL +++ +H D+ Sbjct: 565 EYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYL---ASKKCIHRDLAAR 621 Query: 341 NILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVY 517 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SDV+ Sbjct: 622 NVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY---THQSDVW 678 Query: 518 SFGMLVLEMVSGRRNSDPSVENQD 589 SFG+L+ E+ + + P V ++ Sbjct: 679 SFGVLLWEIFTLGGSPYPGVPMEE 702
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 76.3 bits (186), Expect = 6e-14 Identities = 58/192 (30%), Positives = 100/192 (52%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK ++ + E F+ E + + H +V+L ++ +I E+M SL ++ Sbjct: 286 VAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFL 344 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S + Q L K++D + IA GM ++ Q + +H D++ NIL+ + KI+ Sbjct: 345 KSDEGS-KQPL---PKLIDFSAQIAEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIA 397 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA++ D A+ + + APE NFG + KSDV+SFG+L++E+V+ R Sbjct: 398 DFGLARVI-EDNEYTAREGAKFPIKWTAPEAI--NFGSFTIKSDVWSFGILLMEIVTYGR 454 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 455 IPYPGMSNPEVI 466
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 76.3 bits (186), Expect = 6e-14 Identities = 55/202 (27%), Positives = 105/202 (51%), Gaps = 5/202 (2%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 R + VA+K L+ E + +F++E + +G H NI+ L G ++ +I E+M N Sbjct: 647 RREIFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIHLEGVVTKSRPVMIITEFMEN 706 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ ++ +++ + GIA GM+YL + +H D+ NIL++ Sbjct: 707 CALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKYLSE---MNYVHRDLAARNILVNS 758 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARG---TMGYIAPELYSRNFGGVSYKSDVYSFGM 529 N K+SDFGL++ D + T T++ G + + APE + + + SDV+S+G+ Sbjct: 759 NLVCKVSDFGLSRFLEDDPADPTYTSSLGGKIPIRWTAPEAIA--YRKFTSASDVWSYGI 816 Query: 530 LVLEMVSGRRNSDPSVENQDEV 595 ++ E++S + NQD + Sbjct: 817 VMWEVMSYGERPYWDMSNQDVI 838
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 76.3 bits (186), Expect = 6e-14 Identities = 57/190 (30%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V+L SE ++ EYM SL ++ Sbjct: 295 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFL 353 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + + L ++D+A +A GM Y+ + +H D++ NIL+ KI+ Sbjct: 354 ----KDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGNGLICKIA 406 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 407 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTKGR 463 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 464 VPYPGMNNRE 473
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 76.3 bits (186), Expect = 6e-14 Identities = 58/189 (30%), Positives = 104/189 (55%), Gaps = 14/189 (7%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 VAVKML+S E + + I+E+ + +I H NI+ L+G C++ +I EY +L Sbjct: 509 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 568 Query: 191 KYIFS----------HVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPH 340 +Y+ + + + I ++ L+ ++ A +ARGMEYL +++ +H D+ Sbjct: 569 EYLQARRPPGMEYCYNPTRIPEEQLSFKDLVSCAYQVARGMEYL---ASKKCIHRDLAAR 625 Query: 341 NILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVY 517 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SDV+ Sbjct: 626 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY---THQSDVW 682 Query: 518 SFGMLVLEM 544 SFG+L+ E+ Sbjct: 683 SFGVLLWEI 691
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 76.3 bits (186), Expect = 6e-14 Identities = 58/191 (30%), Positives = 100/191 (52%), Gaps = 3/191 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T EEF+ E + + + H +++L C++ ++ E M + SL +Y+ Sbjct: 265 VAVKTLKPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYL 324 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 + L ++D+ +A GM YL Q Q +H D+ NIL+ + K++ Sbjct: 325 RG-----DGRSLKLPDLVDMCSQVASGMSYLEQ---QNYIHRDLAARNILVGEHKICKVA 376 Query: 380 DFGLAKLCARDQSIL-TLTAARGTMGYIAPE--LYSRNFGGVSYKSDVYSFGMLVLEMVS 550 DFGLA++ D+ I A+ + + APE +YSR + KSDV+SFG+++ E+++ Sbjct: 377 DFGLARVI--DEEIYEAKLGAKFPIKWTAPEAAMYSR----FTIKSDVWSFGIVLYEVIT 430 Query: 551 GRRNSDPSVEN 583 R P + N Sbjct: 431 YGRFPYPGMTN 441
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 76.3 bits (186), Expect = 6e-14 Identities = 57/192 (29%), Positives = 100/192 (52%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK ++ + E F+ E + + H +V+L S+ ++ E+M SL ++ Sbjct: 284 VAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPI-FIVTEFMAKGSLLDFL 342 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S + Q L K++D + I+ GM ++ Q + +H D++ NIL+ + KI+ Sbjct: 343 KSEEGS-KQPL---PKLIDFSAQISEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIA 395 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA++ D A+ + + APE NFG + KSDV+SFG+L++E+V+ R Sbjct: 396 DFGLARII-EDNEYTAREGAKFPIKWTAPEAI--NFGSFTIKSDVWSFGILLMEIVTYGR 452 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 453 IPYPGMSNPEVI 464
>UFO_HUMAN (P30530) Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1)| (AXL oncogene) Length = 887 Score = 75.9 bits (185), Expect = 8e-14 Identities = 61/204 (29%), Positives = 104/204 (50%), Gaps = 11/204 (5%) Frame = +2 Query: 20 VAVKMLE---SSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRR------ALIYEYM 172 VAVK ++ + E E+F++E + H N++RL+G C +G+ R +I +M Sbjct: 557 VAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFM 616 Query: 173 PNESLEKY-IFSHVSNISQKLLAPTKML-DIALGIARGMEYLHQGCNQRILHFDIKPHNI 346 + L + ++S + + Q + PT+ML IA GMEYL +R +H D+ N Sbjct: 617 KHGDLHSFLLYSRLGD--QPVYLPTQMLVKFMADIASGMEYL---STKRFIHRDLAARNC 671 Query: 347 LLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFG 526 +L+ N + ++DFGL+K A+ + +IA E + + KSDV+SFG Sbjct: 672 MLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRV--YTSKSDVWSFG 729 Query: 527 MLVLEMVSGRRNSDPSVENQDEVY 598 + + E+ + + P VEN E+Y Sbjct: 730 VTMWEIATRGQTPYPGVEN-SEIY 752
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 75.9 bits (185), Expect = 8e-14 Identities = 53/173 (30%), Positives = 87/173 (50%) Frame = +2 Query: 38 ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSN 217 E + +E EV + + H NIVR +G E ++ E++P S+ + + Sbjct: 109 EKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAF 168 Query: 218 ISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK 397 + T L + G+EYLH N I+H DIK NIL+D K++DFG +K Sbjct: 169 PESVVRTYTNQLLL------GLEYLH---NHAIMHRDIKGANILVDNQGCIKLADFGASK 219 Query: 398 LCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 556 A +I + +GT ++APE+ + G S+ +D++S G V+EMV+G+ Sbjct: 220 QVAELATISGAKSMKGTPYWMAPEVILQT--GHSFSADIWSVGCTVIEMVTGK 270
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 75.9 bits (185), Expect = 8e-14 Identities = 56/189 (29%), Positives = 99/189 (52%), Gaps = 13/189 (6%) Frame = +2 Query: 23 AVKMLE--SSTGEGEEFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 A+K ++ +S + +F E+ + L HH NI+ L+G C L EY P+ +L Sbjct: 851 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLD 910 Query: 194 YIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHN 343 ++ ++N + L+ ++L A +ARGM+YL Q ++ +H D+ N Sbjct: 911 FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARN 967 Query: 344 ILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSF 523 IL+ N+ KI+DFGL++ + + T R + ++A E S N+ + SDV+S+ Sbjct: 968 ILVGENYIAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIE--SLNYSVYTTNSDVWSY 1022 Query: 524 GMLVLEMVS 550 G+L+ E+VS Sbjct: 1023 GVLLWEIVS 1031
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 75.9 bits (185), Expect = 8e-14 Identities = 56/189 (29%), Positives = 99/189 (52%), Gaps = 13/189 (6%) Frame = +2 Query: 23 AVKMLE--SSTGEGEEFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 A+K ++ +S + +F E+ + L HH NI+ L+G C L EY P+ +L Sbjct: 853 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLD 912 Query: 194 YIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHN 343 ++ ++N + L+ ++L A +ARGM+YL Q ++ +H D+ N Sbjct: 913 FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARN 969 Query: 344 ILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSF 523 IL+ N+ KI+DFGL++ + + T R + ++A E S N+ + SDV+S+ Sbjct: 970 ILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIE--SLNYSVYTTNSDVWSY 1024 Query: 524 GMLVLEMVS 550 G+L+ E+VS Sbjct: 1025 GVLLWEIVS 1033
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 75.9 bits (185), Expect = 8e-14 Identities = 61/196 (31%), Positives = 103/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1109 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1167 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD NF Sbjct: 1168 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDENFTV 1219 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1220 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1276 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1277 LMTRGAPPYPDVNTFD 1292
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 75.9 bits (185), Expect = 8e-14 Identities = 48/168 (28%), Positives = 89/168 (52%), Gaps = 3/168 (1%) Frame = +2 Query: 59 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 + F++E+ + L H +I+ L + +E + L+Y YM N +L + +N + L Sbjct: 220 KRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRL--QCTNGTTPLSW 277 Query: 239 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKL---CAR 409 + + + +GIA+ ++YLH ++ ++ NILLD PK++DF A + Sbjct: 278 HVR-ISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQ 336 Query: 410 DQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 S + +T + PE Y R G +S K+DVYSFG++++E+++G Sbjct: 337 QSSTINMTGGGRKHLWYMPEEYIRQ-GRLSVKTDVYSFGIVIMEVLTG 383
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 75.9 bits (185), Expect = 8e-14 Identities = 56/189 (29%), Positives = 99/189 (52%), Gaps = 13/189 (6%) Frame = +2 Query: 23 AVKMLE--SSTGEGEEFINEVATI-GLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 A+K ++ +S + +F E+ + L HH NI+ L+G C L EY P+ +L Sbjct: 854 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLD 913 Query: 194 YIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHN 343 ++ ++N + L+ ++L A +ARGM+YL Q ++ +H D+ N Sbjct: 914 FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARN 970 Query: 344 ILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSF 523 IL+ N+ KI+DFGL++ + + T R + ++A E S N+ + SDV+S+ Sbjct: 971 ILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIE--SLNYSVYTTNSDVWSY 1025 Query: 524 GMLVLEMVS 550 G+L+ E+VS Sbjct: 1026 GVLLWEIVS 1034
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 75.9 bits (185), Expect = 8e-14 Identities = 50/165 (30%), Positives = 90/165 (54%) Frame = +2 Query: 59 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 E+ ++ + + H NI+ G C++ +I EY + L + + + + + Sbjct: 199 EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAG------RKIT 252 Query: 239 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS 418 P ++D + GIA GM YLH +I+H D+K N+L+ + KISDFG +K + D+S Sbjct: 253 PRLLVDWSTGIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKS 308 Query: 419 ILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 T + GT+ ++APE+ VS K D++SFG+++ E+++G Sbjct: 309 --TKMSFAGTVAWLAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 349
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 75.9 bits (185), Expect = 8e-14 Identities = 58/192 (30%), Positives = 100/192 (52%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK ++ + E F+ E + + H +V+L ++ +I E+M SL ++ Sbjct: 264 VAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFL 322 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 S + Q L K++D + IA GM ++ Q + +H D++ NIL+ + KI+ Sbjct: 323 KSDEGS-KQPL---PKLIDFSAQIAEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIA 375 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA++ D A+ + + APE NFG + KSDV+SFG+L++E+V+ R Sbjct: 376 DFGLARII-EDNEYTAREGAKFPIKWTAPEAI--NFGSSTIKSDVWSFGILLMEIVTYGR 432 Query: 560 NSDPSVENQDEV 595 P + N + + Sbjct: 433 IPYPGMSNPEVI 444
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 75.9 bits (185), Expect = 8e-14 Identities = 58/186 (31%), Positives = 98/186 (52%), Gaps = 6/186 (3%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSE--GTRRALIYEYMPN 178 G VAVK L+ +G + E+ + ++H NIV+ G C E G LI E++P+ Sbjct: 901 GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPS 960 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 SL++Y+ + + I+ K + L A+ I +GM+YL +++ +H D+ N+L++ Sbjct: 961 GSLKEYLPKNKNKINLK-----QQLKYAIQICKGMDYLG---SRQYVHRDLAARNVLVES 1012 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGT-MGYIAPE-LYSRNFGGVSYKSDVYSFGML 532 KI DFGL K D+ T+ R + + + APE L F SDV+SFG+ Sbjct: 1013 EHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKF---YIASDVWSFGVT 1069 Query: 533 VLEMVS 550 + E+++ Sbjct: 1070 LHELLT 1075
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 75.9 bits (185), Expect = 8e-14 Identities = 59/190 (31%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V L SE ++ E+M SL ++ Sbjct: 299 VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMTKGSLLDFL 357 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D+A IA GM Y+ + +H D++ NIL+ N KI+ Sbjct: 358 ----KEGEGKFLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGDNLVCKIA 410 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 411 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTKGR 467 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 468 VPYPGMVNRE 477
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 75.5 bits (184), Expect = 1e-13 Identities = 63/198 (31%), Positives = 104/198 (52%), Gaps = 5/198 (2%) Frame = +2 Query: 20 VAVKM---LESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLE 190 +AVK+ LE + + E E+ + I H N++R++G S G + L+ EY+ SL Sbjct: 35 IAVKIFDFLEETIKKNAE--REITHLSEIDHENVIRVIGRASNGKKDYLLMEYLEEGSLH 92 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 Y++ + + + AL A+ + YLH ++ I+H DIKP N+LL YN + Sbjct: 93 NYLYGD----DKWEYTVEQAVRWALQCAKALAYLH-SLDRPIVHRDIKPQNMLL-YNQHE 146 Query: 371 --KISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 KI DFGLA + ++ T +GT+ Y+APE + K DVYSFG+++ E+ Sbjct: 147 DLKICDFGLATDMSNNK-----TDMQGTLRYMAPEAIKHL--KYTAKCDVYSFGIMLWEL 199 Query: 545 VSGRRNSDPSVENQDEVY 598 ++ R+ +EN + Y Sbjct: 200 MT-RQLPYSHLENPNSQY 216
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 75.5 bits (184), Expect = 1e-13 Identities = 61/196 (31%), Positives = 99/196 (50%), Gaps = 1/196 (0%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFI-NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNE 181 ++ V VA+K++ ++ + +E+ + + H +I+ L S G +I E M Sbjct: 211 KDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKG 270 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 SL + + + +K+L +++LDIA +A GM YL +Q +H D+ NIL+ N Sbjct: 271 SLLELL----RDSDEKVLPVSELLDIAWQVAEGMCYLE---SQNYIHRDLAARNILVGEN 323 Query: 362 FNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLE 541 K+ DFGLA+L D + + APE SR G S KSDV+SFG+L+ E Sbjct: 324 TLCKVGDFGLARLIKED--VYLSHDHNIPYKWTAPEALSR--GHYSTKSDVWSFGILLHE 379 Query: 542 MVSGRRNSDPSVENQD 589 M S + P + N + Sbjct: 380 MFSRGQVPYPGMSNHE 395
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 75.5 bits (184), Expect = 1e-13 Identities = 56/190 (29%), Positives = 99/190 (52%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T + F+ E + L+ H +V+L SE ++ E+M + SL ++ Sbjct: 288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIY-IVTEFMCHGSLLDFL 346 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 N + L +++D+A +A GM Y+ + +H D++ NIL+ KI+ Sbjct: 347 ----KNPEGQDLRLPQLVDMAAQVAEGMAYMER---MNYIHRDLRAANILVGERLACKIA 399 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L +D ++ + + APE + FG + KSDV+SFG+L+ E+++ R Sbjct: 400 DFGLARLI-KDDEYNPCQGSKFPIKWTAPE--AALFGRFTIKSDVWSFGILLTELITKGR 456 Query: 560 NSDPSVENQD 589 P + ++ Sbjct: 457 IPYPGMNKRE 466
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 75.5 bits (184), Expect = 1e-13 Identities = 50/165 (30%), Positives = 90/165 (54%) Frame = +2 Query: 59 EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLA 238 E+ ++ + + H NI+ G C++ +I EY + L + + + + + Sbjct: 199 EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAG------RKIT 252 Query: 239 PTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS 418 P ++D + GIA GM YLH +I+H D+K N+L+ + KISDFG +K + D+S Sbjct: 253 PRLLVDWSTGIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKS 308 Query: 419 ILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 T + GT+ ++APE+ VS K D++SFG+++ E+++G Sbjct: 309 --TKMSFAGTVAWMAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 349
>UFO_MOUSE (Q00993) Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1)| (Adhesion-related kinase) Length = 888 Score = 75.5 bits (184), Expect = 1e-13 Identities = 61/204 (29%), Positives = 104/204 (50%), Gaps = 11/204 (5%) Frame = +2 Query: 20 VAVKMLE---SSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRR------ALIYEYM 172 VAVK ++ + E E+F++E + H N++RL+G C +G+ R +I +M Sbjct: 558 VAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFM 617 Query: 173 PNESLEKY-IFSHVSNISQKLLAPTKML-DIALGIARGMEYLHQGCNQRILHFDIKPHNI 346 + L + ++S + + Q + PT+ML IA GMEYL +R +H D+ N Sbjct: 618 KHGDLHSFLLYSRLGD--QPVFLPTQMLVKFMADIASGMEYL---STKRFIHRDLAARNC 672 Query: 347 LLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFG 526 +L+ N + ++DFGL+K A+ + +IA E + + KSDV+SFG Sbjct: 673 MLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRV--YTSKSDVWSFG 730 Query: 527 MLVLEMVSGRRNSDPSVENQDEVY 598 + + E+ + + P VEN E+Y Sbjct: 731 VTMWEIATRGQTPYPGVEN-SEIY 753
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 75.5 bits (184), Expect = 1e-13 Identities = 59/190 (31%), Positives = 96/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V L SE ++ E+M SL ++ Sbjct: 292 VAIKTLKLGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMTKGSLLDFL 350 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D+A IA GM Y+ + +H D++ NIL+ N KI+ Sbjct: 351 ----KEGEGKFLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGDNLVCKIA 403 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ R Sbjct: 404 DFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTKGR 460 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 461 VPYPGMVNRE 470
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 75.5 bits (184), Expect = 1e-13 Identities = 53/181 (29%), Positives = 94/181 (51%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K L +T +E ++E + + + ++ RL+G C T + LI + MP L Sbjct: 160 IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCL 218 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 YI H NI + L L+ + IA+GM YL + + ++H D+ N+L+ + Sbjct: 219 LDYIREHKDNIGSQYL-----LNWCVQIAKGMNYLEE---RHMVHRDLAARNVLVKTPQH 270 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGLAK D+ + + ++A E +++SDV+S+G+ V E++ Sbjct: 271 VKITDFGLAKQLGADEKEYHAEGGKVPIKWMALESILHRI--YTHQSDVWSYGVTVWELM 328 Query: 548 S 550 + Sbjct: 329 T 329
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 75.1 bits (183), Expect = 1e-13 Identities = 54/192 (28%), Positives = 96/192 (50%), Gaps = 2/192 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+ ++ +G F+ E +G +H +I+RL G ++ +I E+M N +L+ Sbjct: 654 VAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDA 713 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + LAP +++ + LGIA GM L +H D+ NIL++ N K Sbjct: 714 FLKER-----EDQLAPGQLVAMLLGIASGMNCLS---GHNYVHRDLAARNILVNQNLCCK 765 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 +SDFGL +L + + + APE + + SDV+SFG+++ E++S Sbjct: 766 VSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRI--FTTASDVWSFGIVMWEVLSF 823 Query: 554 RRNSDPSVENQD 589 + NQ+ Sbjct: 824 GDKPYGEMSNQE 835
>RTK2_GEOCY (P42159) Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK)| Length = 605 Score = 75.1 bits (183), Expect = 1e-13 Identities = 57/205 (27%), Positives = 102/205 (49%), Gaps = 9/205 (4%) Frame = +2 Query: 8 NGVP-VAVKMLESSTGEG--EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 NGV VAVK L+ E + F E+ + + H +IV+L+ C+ ++ EYM N Sbjct: 385 NGVALVAVKKLKPDVSEEVRQSFDKEIKFVSQLQHDSIVQLLAVCTHSKHPFIVMEYMEN 444 Query: 179 ESLEKYIFSHV-----SNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHN 343 L +++ + S + + P+ +L +A+ IA GM YL + +H D+ N Sbjct: 445 GDLNQFLQKYQMVDDDSALYSNQIPPSTLLYMAVQIASGMVYLS---SLNYVHRDLATRN 501 Query: 344 ILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSF 523 L+ NF KISDFG+++ A + ++A E + +G S KSD +++ Sbjct: 502 CLVGSNFRIKISDFGMSRNLYERVYYRVRGRAMLPIRWMATESF---YGRFSEKSDAWAY 558 Query: 524 GMLVLEMVS-GRRNSDPSVENQDEV 595 G+ V E+ + G++ +++QD + Sbjct: 559 GVTVWEIYTLGKKQPYEELDDQDMI 583
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 75.1 bits (183), Expect = 1e-13 Identities = 61/194 (31%), Positives = 91/194 (46%), Gaps = 13/194 (6%) Frame = +2 Query: 11 GVPVAVKMLESSTGEG-----EEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMP 175 G VAVK E E E ++ H NI+ L G C + L+ E+ Sbjct: 165 GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFAR 224 Query: 176 NESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLD 355 L + + S K + P +++ A+ IARGM YLH I+H D+K NIL+ Sbjct: 225 GGPLNRVL-------SGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILIL 277 Query: 356 Y--------NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSD 511 N KI+DFGL AR+ T +A GT ++APE+ + S SD Sbjct: 278 QKVENGDLSNKILKITDFGL----AREWHRTTKMSAAGTYAWMAPEVIRASM--FSKGSD 331 Query: 512 VYSFGMLVLEMVSG 553 V+S+G+L+ E+++G Sbjct: 332 VWSYGVLLWELLTG 345
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 75.1 bits (183), Expect = 1e-13 Identities = 53/191 (27%), Positives = 92/191 (48%), Gaps = 9/191 (4%) Frame = +2 Query: 11 GVPVAVKMLE----SSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 G VA+K+L + G E F E + + H +VR++ F G L+ E++ Sbjct: 36 GRKVAIKVLHHDLHAQAGMAERFKREARLLSAVEHPAVVRIVDFGESGDHACLVMEFVEG 95 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 ESL ++ + P + L + +A G+ +H ++ I+H D+KP N+ + Sbjct: 96 ESL-------YDVLTPGPMPPGRALPLLQQLAEGLAAIH---DKGIIHRDLKPENVFISK 145 Query: 359 NF---NPKISDFGLAKLCARD--QSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSF 523 + ++ DFG+A+L D S+ + GT Y++PE V +SD+YSF Sbjct: 146 SARGEQARLLDFGIARLVEPDAASSVSQIGVVLGTPEYLSPE--QAVGAKVDTRSDLYSF 203 Query: 524 GMLVLEMVSGR 556 G+L ++SGR Sbjct: 204 GVLTYRVLSGR 214
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/173 (30%), Positives = 87/173 (50%) Frame = +2 Query: 38 ESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSN 217 E + +E EV + + H NIVR +G E ++ E++P S+ + Sbjct: 110 EKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPF 169 Query: 218 ISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK 397 + T+ L + G+EYLH N I+H DIK NIL+D K++DFG +K Sbjct: 170 PESVVRTYTRQLLL------GLEYLH---NHAIMHRDIKGANILVDNKGCIKLADFGASK 220 Query: 398 LCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 556 A ++ + +GT ++APE+ + G S+ +D++S G V+EMV+G+ Sbjct: 221 QVAELATMTGAKSMKGTPYWMAPEVILQT--GHSFSADIWSVGCTVIEMVTGK 271
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 75.1 bits (183), Expect = 1e-13 Identities = 57/186 (30%), Positives = 96/186 (51%), Gaps = 4/186 (2%) Frame = +2 Query: 11 GVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 GV VA+K L+S G I E++ + + H NIVRL + L++EYM N+ Sbjct: 29 GVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLYDVIHTENKLTLVFEYMDND- 87 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L+KY+ S + + L + + G+ + H+ +ILH D+KP N+L+ Sbjct: 88 LKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHEN---KILHRDLKPQNLLITKRG 144 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY--SRNFGGVSYKSDVYSFGMLVL 538 K+ DFGLA+ A + T ++ T+ Y AP++ SR + S D++S G ++ Sbjct: 145 QLKLGDFGLAR--AFGIPVNTFSSEVVTLWYRAPDVLMGSRTY---STSIDIWSCGCILA 199 Query: 539 EMVSGR 556 EM++G+ Sbjct: 200 EMITGK 205
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 75.1 bits (183), Expect = 1e-13 Identities = 56/199 (28%), Positives = 102/199 (51%), Gaps = 2/199 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRA--LIYEYMPN 178 +N + VA+K L+ T E F+ E + + H +VRL TR ++ EYM Sbjct: 254 KNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVV---TREPIYIVTEYMAR 310 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 L ++ ++ +L P +++D++ +A GM Y+ + +H D++ NIL+ Sbjct: 311 GCLLDFL---KTDEGSRLSLP-RLIDMSAQVAEGMAYIER---MNSIHRDLRAANILVSE 363 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 KI+DFGLA++ D A+ + + APE + +FG + K+DV+SFG+L++ Sbjct: 364 TLCCKIADFGLARII--DSEYTAQEGAKFPIKWTAPE--AIHFGVFTIKADVWSFGVLLM 419 Query: 539 EMVSGRRNSDPSVENQDEV 595 +V+ R P + N + + Sbjct: 420 VIVTYGRVPYPGMSNPEVI 438
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 74.7 bits (182), Expect = 2e-13 Identities = 52/183 (28%), Positives = 96/183 (52%), Gaps = 2/183 (1%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 N PVAVK L+ + + +F+ E + + H +++L C+ +I E M + SL Sbjct: 255 NTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSL 314 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++Y+ N + + T+ +D+A +A GM YL ++ +H D+ N+L+ + Sbjct: 315 QEYL----QNDTGSKIHLTQQVDMAAQVASGMAYLE---SRNYIHRDLAARNVLVGEHNI 367 Query: 368 PKISDFGLAKLCARDQSIL--TLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA++ D + + + + + APE N S KSDV+SFG+L+ E Sbjct: 368 YKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSN--KFSIKSDVWSFGILLYE 425 Query: 542 MVS 550 +++ Sbjct: 426 IIT 428
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/153 (31%), Positives = 87/153 (56%) Frame = +2 Query: 95 IHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIA 274 + H NI+ G C++ ++ E+ L + + + + + P+ ++D ++GIA Sbjct: 168 LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG------RPVTPSLLVDWSMGIA 221 Query: 275 RGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 454 GM YLH +I+H D+K N+L+ Y+ KISDFG +K + D+S T + GT+ Sbjct: 222 GGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKS--TKMSFAGTVA 275 Query: 455 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 ++APE+ VS K D++SFG+++ E+++G Sbjct: 276 WMAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 306
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 74.7 bits (182), Expect = 2e-13 Identities = 55/191 (28%), Positives = 102/191 (53%), Gaps = 14/191 (7%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNES 184 V VAVKML+ + + + ++E+ + +I H NI+ L+G C++G ++ EY + Sbjct: 497 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 556 Query: 185 LEKYIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIK 334 L +++ + + ++ L ++ A +ARGMEYL +Q+ +H D+ Sbjct: 557 LREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYL---ASQKCIHRDLA 613 Query: 335 PHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSD 511 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SD Sbjct: 614 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVY---THQSD 670 Query: 512 VYSFGMLVLEM 544 V+SFG+L+ E+ Sbjct: 671 VWSFGVLLWEI 681
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 74.7 bits (182), Expect = 2e-13 Identities = 58/192 (30%), Positives = 97/192 (50%), Gaps = 2/192 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRAL--IYEYMPNESLEK 193 VA+K L+ T E F+ E + + H +V+L S RR + + EYM SL Sbjct: 292 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS---RRPIYIVTEYMSKGSLLI 348 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + L ++D+A +A GM Y+ + +H D++ NIL+ K Sbjct: 349 FL----KDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGNGLICK 401 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 I+DFGLA+L D A+ + + APE + +G + KSDV+SFG+L+ E+V+ Sbjct: 402 IADFGLARLI-EDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILLTELVTK 458 Query: 554 RRNSDPSVENQD 589 R P + N++ Sbjct: 459 GRVPYPGMNNRE 470
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 74.7 bits (182), Expect = 2e-13 Identities = 56/186 (30%), Positives = 98/186 (52%), Gaps = 4/186 (2%) Frame = +2 Query: 11 GVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 GV VA+K L+S G I E++ + + H NIVRL + L++E+M N+ Sbjct: 30 GVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDND- 88 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L+KY+ S + + L + + +G+ + H+ +ILH D+KP N+L++ Sbjct: 89 LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN---KILHRDLKPQNLLINKRG 145 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY--SRNFGGVSYKSDVYSFGMLVL 538 K+ DFGLA+ A + T ++ T+ Y AP++ SR + S D++S G ++ Sbjct: 146 QLKLGDFGLAR--AFGIPVNTFSSEVVTLWYRAPDVLMGSRTY---STSIDIWSCGCILA 200 Query: 539 EMVSGR 556 EM++G+ Sbjct: 201 EMITGK 206
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 74.7 bits (182), Expect = 2e-13 Identities = 57/186 (30%), Positives = 97/186 (52%), Gaps = 4/186 (2%) Frame = +2 Query: 11 GVPVAVK--MLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNES 184 GV VA+K L+S G I E++ + + H NIVRL + L++E+M N+ Sbjct: 30 GVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLFDVIHTENKLTLVFEFMDND- 88 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNF 364 L+K++ + S K L + + +G+ + H+ RILH D+KP N+L++ Sbjct: 89 LKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHEN---RILHRDLKPQNLLINNRG 145 Query: 365 NPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY--SRNFGGVSYKSDVYSFGMLVL 538 K+ DFGLA+ A + T ++ T+ Y AP++ SRN+ D++S G ++ Sbjct: 146 QLKLGDFGLAR--AFGIPVNTFSSEVVTLWYRAPDVLMGSRNY---CTSIDIWSCGCILA 200 Query: 539 EMVSGR 556 EM+ G+ Sbjct: 201 EMIMGK 206
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 74.7 bits (182), Expect = 2e-13 Identities = 59/190 (31%), Positives = 95/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V L SE ++ E+M SL ++ Sbjct: 301 VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFL 359 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D+A IA GM Y+ + +H D++ NIL+ N KI+ Sbjct: 360 ----KEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLVCKIA 412 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L E+V+ R Sbjct: 413 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILQTELVTKGR 469 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 470 VPYPGMVNRE 479
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/153 (31%), Positives = 87/153 (56%) Frame = +2 Query: 95 IHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIA 274 + H NI+ G C++ ++ E+ L + + + + + P+ ++D ++GIA Sbjct: 201 LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG------RPVTPSLLVDWSMGIA 254 Query: 275 RGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 454 GM YLH +I+H D+K N+L+ Y+ KISDFG +K + D+S T + GT+ Sbjct: 255 GGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKS--TKMSFAGTVA 308 Query: 455 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 ++APE+ VS K D++SFG+++ E+++G Sbjct: 309 WMAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 339
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/153 (31%), Positives = 87/153 (56%) Frame = +2 Query: 95 IHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIA 274 + H NI+ G C++ ++ E+ L + + + + + P+ ++D ++GIA Sbjct: 201 LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG------RPVTPSLLVDWSMGIA 254 Query: 275 RGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 454 GM YLH +I+H D+K N+L+ Y+ KISDFG +K + D+S T + GT+ Sbjct: 255 GGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKS--TKMSFAGTVA 308 Query: 455 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 ++APE+ VS K D++SFG+++ E+++G Sbjct: 309 WMAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 339
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 74.7 bits (182), Expect = 2e-13 Identities = 59/190 (31%), Positives = 95/190 (50%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ T E F+ E + + H +V L SE ++ E+M SL ++ Sbjct: 299 VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFL 357 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 K L +++D+A IA GM Y+ + +H D++ NIL+ N KI+ Sbjct: 358 ----KEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLICKIA 410 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + +G + KSDV+SFG+L E+V+ R Sbjct: 411 DFGLARL-IEDNEYTARQGAKFPIKWTAPE--AALYGRFTIKSDVWSFGILQTELVTKGR 467 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 468 VPYPGMVNRE 477
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/181 (28%), Positives = 95/181 (52%), Gaps = 2/181 (1%) Frame = +2 Query: 14 VPVAVKMLESSTGE--GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 +PVA+K+L +T +E ++E + + H ++ RL+G C + L+ + MP L Sbjct: 738 IPVAIKVLREATSPKVNQEVLDEAYVMASVDHPHVCRLLGICLTSAVQ-LVTQLMPYGCL 796 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 Y+ H I + L L+ + IA+GM YL + + ++H D+ N+LL + Sbjct: 797 LDYVRQHQERICGQWL-----LNWCVQIAKGMNYLEE---RHLVHRDLAARNVLLKNPNH 848 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 KI+DFGL+KL D+ + + ++A E + +++SDV+S+G+ V E++ Sbjct: 849 VKITDFGLSKLLTADEKEYQADGGKVPIKWMALESILQ--WTYTHQSDVWSYGVTVWELM 906 Query: 548 S 550 + Sbjct: 907 T 907
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 74.3 bits (181), Expect = 2e-13 Identities = 58/190 (30%), Positives = 97/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T + F+ E + L+ H +V+L SE ++ E+M SL ++ Sbjct: 276 VAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIY-IVTEFMCYGSLLDFL 334 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 Q L+ P ++D+A +A GM Y+ + +H D++ NIL+ KI+ Sbjct: 335 KDREG---QNLMLP-HLVDMAAQVAEGMAYMER---MNYIHRDLRAANILVGEYLICKIA 387 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D + + + APE + FG + KSDV+SFG+L+ E+++ R Sbjct: 388 DFGLARLI-EDNEYNPQQGTKFPIKWTAPE--AALFGRFTVKSDVWSFGILLTELITKGR 444 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 445 VPYPGMNNRE 454
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 74.3 bits (181), Expect = 2e-13 Identities = 53/192 (27%), Positives = 94/192 (48%), Gaps = 2/192 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+ ++ G+ F+ E +G H +I+ L G ++ +I E+M N +L+ Sbjct: 653 VAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDA 712 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + L P +++ + GIA GM YL N +H D+ NIL++ N K Sbjct: 713 FLRER-----EDQLVPGQLVAMLQGIASGMNYLS---NHNYVHRDLAARNILVNQNLCCK 764 Query: 374 ISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 +SDFGL +L + + + APE + + SDV+SFG+++ E++S Sbjct: 765 VSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRI--FTTASDVWSFGIVMWEVLSF 822 Query: 554 RRNSDPSVENQD 589 + NQ+ Sbjct: 823 GDKPYGEMSNQE 834
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 73.9 bits (180), Expect = 3e-13 Identities = 57/190 (30%), Positives = 102/190 (53%), Gaps = 1/190 (0%) Frame = +2 Query: 11 GVPVAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMG-FCSEGTRRALIYEYMPNESL 187 G VAVK ++ + F++E A + + H N+VRL+G +G ++ E++ +L Sbjct: 256 GQKVAVKNIKCDV-TAQAFLDETAVMTKMQHENLVRLLGVILHQGLY--IVMEHVSKGNL 312 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ + + L+ ++L +L +A GMEYL +++++H D+ NIL+ + Sbjct: 313 VNFLRTR----GRALVNTAQLLQFSLHVAEGMEYLE---SKKLVHRDLAARNILVSEDLV 365 Query: 368 PKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 547 K+SDFGLAK + L ++R + + APE + G + KSDV+SFG+L+ E+ Sbjct: 366 AKVSDFGLAKAERKG-----LDSSRLPVKWTAPE--ALKHGKFTSKSDVWSFGVLLWEVF 418 Query: 548 SGRRNSDPSV 577 S R P + Sbjct: 419 SYGRAPYPKM 428
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 73.9 bits (180), Expect = 3e-13 Identities = 59/193 (30%), Positives = 98/193 (50%), Gaps = 1/193 (0%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VA+K L+ + F+ E + + H +VRL ++ +I EYM SL ++ Sbjct: 268 VAIKNLKQGSMSPSAFLAEANLMKNLQHPRLVRLYAVVTKEPIY-IITEYMEKGSLVDFL 326 Query: 200 FSHVSNISQKL-LAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKI 376 S+ + L+ K+LD+A IA GM ++ + +H D++ NIL+ KI Sbjct: 327 -----KTSEGIKLSINKLLDMAAQIAEGMAFIEA---KNYIHRDLRAANILVSEALCCKI 378 Query: 377 SDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 556 +DFGLA+L D A+ + + APE N+G + KSDV+SFG+L+ E+V+ Sbjct: 379 ADFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTFTIKSDVWSFGILLTEIVTYG 435 Query: 557 RNSDPSVENQDEV 595 R P + N + + Sbjct: 436 RIPYPGMTNPEVI 448
>JAK3_HUMAN (P52333) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 73.9 bits (180), Expect = 3e-13 Identities = 59/195 (30%), Positives = 102/195 (52%), Gaps = 5/195 (2%) Frame = +2 Query: 11 GVPVAVKMLE-SSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRAL--IYEYMPNE 181 G VAVK L+ S + +F E+ + +H IV+ G R++L + EY+P+ Sbjct: 849 GALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSG 908 Query: 182 SLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 L ++ H + + +++L + I +GMEYL ++R +H D+ NIL++ Sbjct: 909 CLRDFLQRHRARLDA-----SRLLLYSSQICKGMEYLG---SRRCVHRDLAARNILVESE 960 Query: 362 FNPKISDFGLAKLCARDQSILTL-TAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 + KI+DFGLAKL D+ + + + + APE S N S +SDV+SFG+++ Sbjct: 961 AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNI--FSRQSDVWSFGVVLY 1018 Query: 539 EMVS-GRRNSDPSVE 580 E+ + ++ PS E Sbjct: 1019 ELFTYCDKSCSPSAE 1033
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 73.9 bits (180), Expect = 3e-13 Identities = 60/194 (30%), Positives = 90/194 (46%), Gaps = 13/194 (6%) Frame = +2 Query: 11 GVPVAVKMLESSTGE-----GEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMP 175 G VAVK E E E ++ H NI+ L C E L+ EY Sbjct: 138 GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAA 197 Query: 176 NESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLD 355 L + + + + + P +++ A+ IARGM YLH ++H D+K +NILL Sbjct: 198 GGPLSRAL-------AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLL 250 Query: 356 YNFNP--------KISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSD 511 KI+DFGL AR+ T +A GT ++APE+ + S SD Sbjct: 251 QPIESDDMEHKTLKITDFGL----AREWHKTTQMSAAGTYAWMAPEVIKAS--TFSKGSD 304 Query: 512 VYSFGMLVLEMVSG 553 V+SFG+L+ E+++G Sbjct: 305 VWSFGVLLWELLTG 318
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 73.6 bits (179), Expect = 4e-13 Identities = 56/207 (27%), Positives = 104/207 (50%), Gaps = 21/207 (10%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VAVKML+ + + E + ++E + ++H ++++L G CS+ LI EY SL Sbjct: 756 VAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRG 815 Query: 194 YI------------------FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRIL 319 ++ S + + +++L ++ A I+RGM+YL +++ Sbjct: 816 FLRDSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYL---AEMKLV 872 Query: 320 HFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGV 496 H D+ NIL+ KISDFGL++ + S + + R + ++A E L+ + Sbjct: 873 HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIY--- 929 Query: 497 SYKSDVYSFGMLVLEMVSGRRNSDPSV 577 + +SDV+SFG+L+ E+V+ N P + Sbjct: 930 TTQSDVWSFGVLLWEIVTLGGNPYPGI 956
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1108 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1166 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1167 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1218 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1219 KVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1275 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1276 LMTRGAPPYPDVNTFD 1291
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1108 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1166 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1167 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1218 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1219 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1275 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1276 LMTRGAPPYPDVNTFD 1291
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1108 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1166 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1167 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1218 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1219 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1275 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1276 LMTRGAPPYPDVNTFD 1291
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1108 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1166 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1167 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1218 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1219 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1275 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1276 LMTRGAPPYPDVNTFD 1291
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1109 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1167 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1168 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1219 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1220 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1276 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1277 LMTRGAPPYPDVNTFD 1292
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1109 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1167 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1168 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1219 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1220 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1276 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1277 LMTRGAPPYPDVNTFD 1292
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 73.6 bits (179), Expect = 4e-13 Identities = 59/196 (30%), Positives = 92/196 (46%), Gaps = 14/196 (7%) Frame = +2 Query: 8 NGVPVAVKMLESSTGEGE------EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEY 169 +G VA+K+ TGE + + E + H NI L G C T+ L+ EY Sbjct: 162 DGEEVAIKIAHQ-TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLN-TKLCLVMEY 219 Query: 170 MPNESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNIL 349 SL + + + P +++ A+ IARGM YLH I+H D+K N+L Sbjct: 220 ARGGSLNRILAGKIP--------PDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVL 271 Query: 350 LDYNFNP--------KISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYK 505 + KI+DFGLA+ Q + +A GT ++ PE+ S S Sbjct: 272 IYEAIEGNHLQQKTLKITDFGLAREMYNTQRM----SAAGTYAWMPPEVIS--VSTYSKF 325 Query: 506 SDVYSFGMLVLEMVSG 553 SDV+S+G+L+ E+++G Sbjct: 326 SDVWSYGVLLWELITG 341
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1108 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1166 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1167 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1218 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1219 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1275 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1276 LMTRGAPPYPDVNTFD 1291
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 73.6 bits (179), Expect = 4e-13 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 7/196 (3%) Frame = +2 Query: 23 AVKMLESST--GEGEEFINEVATIGLIHHANIVRLMGFC--SEGTRRALIYEYMPNESLE 190 AVK L T GE +F+ E + H N++ L+G C SEG+ ++ YM + L Sbjct: 1108 AVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1166 Query: 191 KYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNP 370 +I + N + K ++ L +A+GM+YL +++ +H D+ N +LD F Sbjct: 1167 NFIRNETHNPTVK-----DLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEKFTV 1218 Query: 371 KISDFGLAKLCARDQ--SILTLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFGMLVLE 541 K++DFGLA+ + S+ T A+ + ++A E L ++ F + KSDV+SFG+L+ E Sbjct: 1219 KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF---TTKSDVWSFGVLLWE 1275 Query: 542 MVSGRRNSDPSVENQD 589 +++ P V D Sbjct: 1276 LMTRGAPPYPDVNTFD 1291
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 73.6 bits (179), Expect = 4e-13 Identities = 56/180 (31%), Positives = 93/180 (51%), Gaps = 2/180 (1%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFI-NEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKY 196 VA+K + + +EFI NE+ + HH NIV + + ++ EYM SL + Sbjct: 412 VAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEV 471 Query: 197 IFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKI 376 + ++ L+ ++ I G+++LH+ I+H DIK NILL + K+ Sbjct: 472 VTNNT-------LSEGQIAAICKETLEGLQHLHEN---GIVHRDIKSDNILLSLQGDIKL 521 Query: 377 SDFGLAKLCAR-DQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 553 +DFG CA+ D ++ T GT ++APE+ +R G +K DV+S G++ +EMV G Sbjct: 522 TDFG---FCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYG--FKVDVWSLGIMAIEMVEG 576
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 73.6 bits (179), Expect = 4e-13 Identities = 63/187 (33%), Positives = 92/187 (49%), Gaps = 8/187 (4%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGT-----RRALIYEYMPNES 184 VAVK++ S ++ EV + + H N++ L+G AL+ +M N S Sbjct: 48 VAVKIVNS-----KKISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGS 102 Query: 185 LEKYIFSHVSNISQKLLAPTKMLDIALG-IARGMEYLHQGCNQRILHFDIKPHNILLDYN 361 L + P +L L + GM YLH N +LH D+KP N+LLD Sbjct: 103 LSGLL-------QPSCPRPWPLLCRLLEEVVLGMCYLHS-LNPSLLHRDLKPSNVLLDLE 154 Query: 362 FNPKISDFGLAKLCARDQSILTLTA--ARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLV 535 + K++DFGL+ QS + + GT+ Y+APEL N G S SDVYSFG+LV Sbjct: 155 LHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLD-NDGKASKASDVYSFGVLV 213 Query: 536 LEMVSGR 556 +++GR Sbjct: 214 WTVLAGR 220
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 73.2 bits (178), Expect = 5e-13 Identities = 52/184 (28%), Positives = 94/184 (51%), Gaps = 5/184 (2%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFIN----EVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESL 187 VA+K+L E F+ E + H NIV + EG ++ EY+ +L Sbjct: 36 VAIKILRPEFAADENFVKKFKRESQAAASLSHPNIVGIYDVGQEGDIYYIVMEYVKGRTL 95 Query: 188 EKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFN 367 ++ I + + K + ++IA + R +++ H+ +I+H DIKP NIL+ Sbjct: 96 KELIRENGGPLEVK-----RAVEIASQVCRALDHAHKN---KIIHRDIKPQNILVTDEDV 147 Query: 368 PKISDFGLAKLCARDQSILTLTA-ARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEM 544 K++DFG+A+ A + + +T T GT Y +PE + V ++D+YS G+++ EM Sbjct: 148 VKVTDFGIAR--AANGATITYTGDVIGTAYYFSPEQAKGSI--VDERTDIYSLGIVLFEM 203 Query: 545 VSGR 556 ++G+ Sbjct: 204 LTGK 207
>EPHAA_HUMAN (Q5JZY3) Ephrin type-A receptor 10 precursor (EC 2.7.10.1)| Length = 1008 Score = 73.2 bits (178), Expect = 5e-13 Identities = 52/184 (28%), Positives = 95/184 (51%), Gaps = 2/184 (1%) Frame = +2 Query: 5 RNGVPVAVKMLESSTGEGEE--FINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPN 178 R + VAV ML S + + F+ E T+G H++IVRL G + G+ ++ EYM + Sbjct: 669 RQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSH 728 Query: 179 ESLEKYIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDY 358 +L+ ++ H + L +++ + G+A M+YL + +H + ++L+ Sbjct: 729 GALDGFLRRH-----EGQLVAGQLMGLLPGLASAMKYLSE---MGYVHRGLAARHVLVSS 780 Query: 359 NFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVL 538 + KIS FG R +++ T + R + APE + FG S SDV+SFG+++ Sbjct: 781 DLVCKISGFGRGPR-DRSEAVYTTMSGRSPALWAAPE--TLQFGHFSSASDVWSFGIIMW 837 Query: 539 EMVS 550 E+++ Sbjct: 838 EVMA 841
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 73.2 bits (178), Expect = 5e-13 Identities = 59/188 (31%), Positives = 97/188 (51%), Gaps = 11/188 (5%) Frame = +2 Query: 20 VAVKMLES--STGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L+S S EF+ E +G H N++RL+G + ++ EYM N SL++ Sbjct: 745 VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQ 804 Query: 194 YIFSHVSNISQK--LLAPTKMLDIALGIARGMEYL-HQGCNQRILHF-DIKPHNILLDYN 361 ++ N Q+ + K+ ++ GIA GM+YL G R+ D+ N+LLD Sbjct: 805 FL----RNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDME 860 Query: 362 FNPKISDFGLAKLCARDQSIL----TLTAARGTMGYIAPE-LYSRNFGGVSYKSDVYSFG 526 KI+DFGL++ + S + T + + + APE + R F + SDV+SFG Sbjct: 861 LRCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKF---TPSSDVWSFG 917 Query: 527 MLVLEMVS 550 +++ E+ S Sbjct: 918 VVIWEVCS 925
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 73.2 bits (178), Expect = 5e-13 Identities = 54/191 (28%), Positives = 101/191 (52%), Gaps = 14/191 (7%) Frame = +2 Query: 14 VPVAVKMLESSTGEGE--EFINEVATIGLI-HHANIVRLMGFCSEGTRRALIYEYMPNES 184 + VAVKML+ + + + ++E+ + +I H NI+ L+G C++ ++ EY + Sbjct: 497 ITVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGN 556 Query: 185 LEKYIFSH----------VSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIK 334 L +Y+ + + ++ L ++ A +ARGMEYL +Q+ +H D+ Sbjct: 557 LREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYL---ASQKCIHRDLA 613 Query: 335 PHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFGGVSYKSD 511 N+L+ + KI+DFGLA+ T R + ++APE L+ R + +++SD Sbjct: 614 ARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVY---THQSD 670 Query: 512 VYSFGMLVLEM 544 V+SFG+L+ E+ Sbjct: 671 VWSFGVLLWEI 681
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 73.2 bits (178), Expect = 5e-13 Identities = 58/190 (30%), Positives = 98/190 (51%) Frame = +2 Query: 20 VAVKMLESSTGEGEEFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEKYI 199 VAVK L+ T + + E + L+ H +V+L E ++ E+M + SL +++ Sbjct: 311 VAVKTLKPGTMSPKASLEEAQIMKLLRHDKLVQLYAVVPEEPIY-IVTEFMCHGSLLEFL 369 Query: 200 FSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPKIS 379 Q L P +++D+A +A GM Y+ + +H D++ NIL+ KI+ Sbjct: 370 KDQEG---QDLTLP-QLVDMAAQVAEGMAYMER---MDYIHRDLRAANILVGERLVCKIA 422 Query: 380 DFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 559 DFGLA+L D A+ + + APE + FG + KSDV+SFG+L+ E++S R Sbjct: 423 DFGLARLI-EDNEYNPRQGAKFPIKWTAPE--AALFGRFTIKSDVWSFGILLTELISKGR 479 Query: 560 NSDPSVENQD 589 P + N++ Sbjct: 480 VPYPGMNNRE 489
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 72.8 bits (177), Expect = 7e-13 Identities = 56/204 (27%), Positives = 104/204 (50%), Gaps = 12/204 (5%) Frame = +2 Query: 20 VAVKMLESSTGEGE--EFINEVATIGLIHHANIVRLMGFCSEGTRRALIYEYMPNESLEK 193 VA+K L++ + + +F++E + +G H NI+RL G ++ +I EYM N SL+ Sbjct: 24 VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDA 83 Query: 194 YIFSHVSNISQKLLAPTKMLDIALGIARGMEYLHQGCNQRILHFDIKPHNILLDYNFNPK 373 ++ + + +++ I GIA GM+YL + +H D+ NIL++ N K Sbjct: 84 FLRKNDGRFT-----VIQLVGILRGIASGMKYL---SDMSYVHRDLAARNILVNSNLVCK 135 Query: 374 ISDFGLAKLCARD-QSILTLTAARGT---------MGYIAPELYSRNFGGVSYKSDVYSF 523 +SDFG++++ D + T GT + + APE + + + SDV+S+ Sbjct: 136 VSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAIT--YRKFTSASDVWSY 193 Query: 524 GMLVLEMVSGRRNSDPSVENQDEV 595 G+++ E++S + NQD + Sbjct: 194 GIVMWEVMSYGERPYWDMSNQDVI 217 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 90,806,397 Number of Sequences: 219361 Number of extensions: 1991057 Number of successful extensions: 8500 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6809 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7183 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5253413348 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
