ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baal13c04 |
|---|---|
| Clone Library Name | barley_pub |
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 202 bits (515), Expect = 5e-52 Identities = 104/199 (52%), Positives = 138/199 (69%), Gaps = 8/199 (4%) Frame = +3 Query: 18 KRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL 197 +R +L+W +R I G+ARGLLYLH++S +IIHRD+K SN+LLD+ + PKISDFGMAR+ Sbjct: 618 RRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARI 677 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDE 377 F D T NT ++ GTYGYM+PEYAM G S K+DVFSFG++VLEIVSG+KN + D Sbjct: 678 FERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKKNRGFYNLDY 737 Query: 378 KVDLLNYTWKLSEEGRSLEIVDPGL--------SGWDAGEVGMCVQLGLLCCQAVVSERP 533 + DLL+Y W +EGR+LEIVDP + S + EV C+Q+GLLC Q + RP Sbjct: 738 ENDLLSYVWSRWKEGRALEIVDPVIVDSLSSQPSIFQPQEVLKCIQIGLLCVQELAEHRP 797 Query: 534 DMYSVHLMLSSDSFTLPKP 590 M SV M S++ +P+P Sbjct: 798 AMSSVVWMFGSEATEIPQP 816
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 149 bits (376), Expect = 6e-36 Identities = 83/183 (45%), Positives = 114/183 (62%), Gaps = 3/183 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 LDWPKR +I LG ARGL YLH+ KIIHRD+KA+N+LLDE+ + DFG+A+L Sbjct: 385 LDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYK 444 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID--RHLGDEKV 383 THV T + GT G++APEY G S KTDVF +G+++LE+++G++ D R D+ V Sbjct: 445 DTHVTT-AVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDV 503 Query: 384 DLLNYTWKLSEEGRSLEIVDPGLSG-WDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLML 560 LL++ L +E + +VD L G + EV +Q+ LLC Q+ ERP M V ML Sbjct: 504 MLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRML 563 Query: 561 SSD 569 D Sbjct: 564 EGD 566
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 133 bits (335), Expect = 3e-31 Identities = 74/181 (40%), Positives = 115/181 (63%), Gaps = 3/181 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF-LE 206 LDW R +I G A+GL +LH+++ +I+RD K+SN+LLDE +PK+SDFG+A+L Sbjct: 182 LDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTG 241 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVD 386 D +HV+T R+ GTYGY APEYAM G L+ K+DV+SFG++ LE+++GRK ID + + + Sbjct: 242 DKSHVST-RVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQN 300 Query: 387 LLNYTWKLSEEGRS-LEIVDPGLSG-WDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLML 560 L+ + L + R +++ DP L G + + + + +C Q + RP + V L Sbjct: 301 LVAWARPLFNDRRKFIKLADPRLKGRFPTRALYQALAVASMCIQEQAATRPLIADVVTAL 360 Query: 561 S 563 S Sbjct: 361 S 361
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 131 bits (330), Expect = 1e-30 Identities = 74/181 (40%), Positives = 114/181 (62%), Gaps = 3/181 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE- 206 LDW R +I G ARGL YLH+ +I+RD+K SN+LL E PK+SDFG+A++ Sbjct: 199 LDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSG 258 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVD 386 D THV+T R+ GTYGY AP+YAM G L+ K+D++SFG+++LE+++GRK ID + + Sbjct: 259 DKTHVST-RVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKDQN 317 Query: 387 LLNYTWKLSEEGRSL-EIVDPGLSG-WDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLML 560 L+ + L ++ R+ ++VDP L G + + + + +C Q + RP + V L L Sbjct: 318 LVGWARPLFKDRRNFPKMVDPLLQGQYPVRGLYQALAISAMCVQEQPTMRPVVSDVVLAL 377 Query: 561 S 563 + Sbjct: 378 N 378
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 127 bits (320), Expect = 2e-29 Identities = 69/175 (39%), Positives = 110/175 (62%), Gaps = 2/175 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 LDW KR +I +G ARGL +LH IIHRDIKASN+LLD PK++DFG+ARL Sbjct: 1012 LDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISAC 1071 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGD-EKVD 386 +HV+T I+GT+GY+ PEY + +TK DV+SFG+++LE+V+G++ + E + Sbjct: 1072 ESHVSTV-IAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEPTGPDFKESEGGN 1130 Query: 387 LLNYTWKLSEEGRSLEIVDPGLSGWDAGEVGM-CVQLGLLCCQAVVSERPDMYSV 548 L+ + + +G++++++DP L + +Q+ +LC ++RP+M V Sbjct: 1131 LVGWAIQKINQGKAVDVIDPLLVSVALKNSQLRLLQIAMLCLAETPAKRPNMLDV 1185
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 126 bits (316), Expect = 5e-29 Identities = 71/178 (39%), Positives = 106/178 (59%), Gaps = 2/178 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 LDW R +I +G ARGL +LH IIHRD+K+SNVLLD+ ++SDFGMARL Sbjct: 954 LDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSAL 1013 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 TH++ ++GT GY+ PEY + + K DV+S+G+++LE++SG+K ID E +L Sbjct: 1014 DTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPEEFGEDNNL 1073 Query: 390 LNYTWKLSEEGRSLEIVDPGLSGWDAGEVGMC--VQLGLLCCQAVVSERPDMYSVHLM 557 + + +L E R EI+DP L +G+V + +++ C +RP M V M Sbjct: 1074 VGWAKQLYREKRGAEILDPELVTDKSGDVELLHYLKIASQCLDDRPFKRPTMIQVMTM 1131
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 125 bits (314), Expect = 9e-29 Identities = 69/178 (38%), Positives = 103/178 (57%), Gaps = 1/178 (0%) Frame = +3 Query: 18 KRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL 197 KR LDWP R I LG ARGL YLH +IHRD+K+SN+LLD+ + K++DFG ++ Sbjct: 687 KRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKY 746 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDE 377 ++ + + GT GY+ PEY LS K+DVFSFG+++LEIVSGR+ ++ Sbjct: 747 APQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRI 806 Query: 378 KVDLLNYTWKLSEEGRSLEIVDPGL-SGWDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 + L+ + + EIVDPG+ G+ A + V++ L C + + RP M + Sbjct: 807 EWSLVEWAKPYIRASKVDEIVDPGIKGGYHAEALWRVVEVALQCLEPYSTYRPCMVDI 864
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 125 bits (313), Expect = 1e-28 Identities = 70/180 (38%), Positives = 107/180 (59%), Gaps = 2/180 (1%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 + L+W R +I +G ARGL +LH IIHRD+K+SNVLLDE ++SDFGMARL Sbjct: 954 IYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVS 1013 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKV 383 TH++ ++GT GY+ PEY + + K DV+S+G+++LE++SG+K ID E Sbjct: 1014 ALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDN 1073 Query: 384 DLLNYTWKLSEEGRSLEIVDPGLSGWDAGEVGM--CVQLGLLCCQAVVSERPDMYSVHLM 557 +L+ + +L E R EI+DP L +G+V + +++ C +RP M + M Sbjct: 1074 NLVGWAKQLYREKRGAEILDPELVTDKSGDVELFHYLKIASQCLDDRPFKRPTMIQLMAM 1133
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 125 bits (313), Expect = 1e-28 Identities = 69/178 (38%), Positives = 102/178 (57%), Gaps = 1/178 (0%) Frame = +3 Query: 18 KRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL 197 KR LDWP R I LG ARGL YLH +IHRD+K+SN+LLD + K++DFG ++ Sbjct: 686 KRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKY 745 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDE 377 ++ + + GT GY+ PEY LS K+DVFSFG+++LEIVSGR+ ++ Sbjct: 746 APQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRV 805 Query: 378 KVDLLNYTWKLSEEGRSLEIVDPGL-SGWDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 + L+ + + EIVDPG+ G+ A + V++ L C + + RP M + Sbjct: 806 EWSLVEWAKPYIRASKVDEIVDPGIKGGYHAEALWRVVEVALQCLEPYSTYRPCMVDI 863
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 124 bits (310), Expect = 3e-28 Identities = 73/176 (41%), Positives = 108/176 (61%), Gaps = 3/176 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF-LE 206 L W R ++ LG ARGL +LH P ++I+RD KASN+LLD N K+SDFG+AR + Sbjct: 173 LSWNTRVRMALGAARGLAFLHNAQP-QVIYRDFKASNILLDSNYNAKLSDFGLARDGPMG 231 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVD 386 D +HV+T R+ GT GY APEY G+LS K+DV+SFG+++LE++SGR+ ID++ + + Sbjct: 232 DNSHVST-RVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKNQPVGEHN 290 Query: 387 LLNYTWK-LSEEGRSLEIVDPGLSG-WDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 L+++ L+ + R L ++DP L G + L L C RP M + Sbjct: 291 LVDWARPYLTNKRRLLRVMDPRLQGQYSLTRALKIAVLALDCISIDAKSRPTMNEI 346
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 124 bits (310), Expect = 3e-28 Identities = 65/192 (33%), Positives = 109/192 (56%), Gaps = 7/192 (3%) Frame = +3 Query: 12 GXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMA 191 G K L W RH++ + A+GL YLH + I+HRD+K++N+LLD ++DFG+A Sbjct: 780 GSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLA 839 Query: 192 RLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLG 371 + ++ A I+G+YGY+APEYA + K+DV+SFG+++LE+++G+K + Sbjct: 840 KFLVDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGKKPVGEF-- 897 Query: 372 DEKVDLLNYTWKLSEE-------GRSLEIVDPGLSGWDAGEVGMCVQLGLLCCQAVVSER 530 E VD++ + EE + IVDP L+G+ V ++ ++C + + R Sbjct: 898 GEGVDIVRWVRNTEEEITQPSDAAIVVAIVDPRLTGYPLTSVIHVFKIAMMCVEEEAAAR 957 Query: 531 PDMYSVHLMLSS 566 P M V ML++ Sbjct: 958 PTMREVVHMLTN 969
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 123 bits (309), Expect = 3e-28 Identities = 72/197 (36%), Positives = 114/197 (57%), Gaps = 17/197 (8%) Frame = +3 Query: 9 TGXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGM 188 TG KR L W +R +I G A+GL +LH IIHRD+K+SNVLLD+ + ++SDFGM Sbjct: 928 TGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGM 987 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDR-H 365 ARL TH++ ++GT GY+ PEY + + K DV+S G+++LEI+SG++ D+ Sbjct: 988 ARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDKEE 1047 Query: 366 LGDEKVDLLNYTWKLSEEGRSLEIVDPGL------------SGWDAG----EVGMCVQLG 497 GD +L+ ++ + EG+ +E++D L G++ G E+ +++ Sbjct: 1048 FGD--TNLVGWSKMKAREGKHMEVIDEDLLKEGSSESLNEKEGFEGGVIVKEMLRYLEIA 1105 Query: 498 LLCCQAVVSERPDMYSV 548 L C S+RP+M V Sbjct: 1106 LRCVDDFPSKRPNMLQV 1122
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 123 bits (308), Expect = 5e-28 Identities = 69/179 (38%), Positives = 102/179 (56%), Gaps = 6/179 (3%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 LDW RH I +G A GL YLH + I+HRDIK N+LLD L P ISDFG+A+L + Sbjct: 911 LDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQS 970 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 AT + + + GT GYMAPE A S ++DV+S+G+++LE+++ +K +D E D+ Sbjct: 971 ATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKKALDPSFNGE-TDI 1029 Query: 390 LNYTWKL-SEEGRSLEIVDPGL-----SGWDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 + + + ++ G +IVDP L +V + L L C + V +RP M V Sbjct: 1030 VGWVRSVWTQTGEIQKIVDPSLLDELIDSSVMEQVTEALSLALRCAEKEVDKRPTMRDV 1088
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 121 bits (303), Expect = 2e-27 Identities = 67/189 (35%), Positives = 107/189 (56%), Gaps = 2/189 (1%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL-- 197 V L WP+R +I L A GL YLH + I+HRD+K+SN+LLD K++DFG+A++ Sbjct: 786 VVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQ 845 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDE 377 T I+G+ GY+APEY ++ K+D++SFG+++LE+V+G++ D LGD+ Sbjct: 846 MSGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQPTDSELGDK 905 Query: 378 KVDLLNYTWKLSEEGRSLEIVDPGLSGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLM 557 D+ + ++ ++DP L E+ + +GLLC + RP M V +M Sbjct: 906 --DMAKWVCTALDKCGLEPVIDPKLDLKFKEEISKVIHIGLLCTSPLPLNRPSMRKVVIM 963 Query: 558 LSSDSFTLP 584 L S +P Sbjct: 964 LQEVSGAVP 972
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 121 bits (303), Expect = 2e-27 Identities = 66/181 (36%), Positives = 109/181 (60%), Gaps = 4/181 (2%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 W +R + L +ARG+ YLH + IHRD+K SN+LL + + K++DFG+ RL E Sbjct: 688 WKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKG 747 Query: 216 HVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLN 395 + T RI+GT+GY+APEYA+ G ++TK DV+SFG++++E+++GRK++D +E + L++ Sbjct: 748 SIET-RIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRKSLDESQPEESIHLVS 806 Query: 396 YTWK--LSEEGRSLEIVDP--GLSGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLMLS 563 + + +++E + +D L V +L CC +RPDM +LS Sbjct: 807 WFKRMYINKEASFKKAIDTTIDLDEETLASVHTVAELAGHCCAREPYQRPDMGHAVNILS 866 Query: 564 S 566 S Sbjct: 867 S 867
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 120 bits (301), Expect = 3e-27 Identities = 71/182 (39%), Positives = 109/182 (59%), Gaps = 4/182 (2%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 ++L+WP R +I +G ARGL +LH IIHRD+K+SNVLLDE L ++SDFGMARL Sbjct: 981 IKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMS 1040 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID-RHLGDEK 380 TH++ ++GT GY+ PEY + STK DV+S+G+++LE+++G++ D GD Sbjct: 1041 AMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTDSADFGDN- 1099 Query: 381 VDLLNYTWKLSEEGRSLEIVDPGLSGWDAG---EVGMCVQLGLLCCQAVVSERPDMYSVH 551 +L+ + KL +G+ ++ D L DA E+ +++ C +RP M V Sbjct: 1100 -NLVGWV-KLHAKGKITDVFDRELLKEDASIEIELLQHLKVACACLDDRHWKRPTMIQVM 1157 Query: 552 LM 557 M Sbjct: 1158 AM 1159
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 120 bits (301), Expect = 3e-27 Identities = 71/182 (39%), Positives = 109/182 (59%), Gaps = 4/182 (2%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 ++L+WP R +I +G ARGL +LH IIHRD+K+SNVLLDE L ++SDFGMARL Sbjct: 981 IKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMS 1040 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID-RHLGDEK 380 TH++ ++GT GY+ PEY + STK DV+S+G+++LE+++G++ D GD Sbjct: 1041 AMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTDSADFGDN- 1099 Query: 381 VDLLNYTWKLSEEGRSLEIVDPGLSGWDAG---EVGMCVQLGLLCCQAVVSERPDMYSVH 551 +L+ + KL +G+ ++ D L DA E+ +++ C +RP M V Sbjct: 1100 -NLVGWV-KLHAKGKITDVFDRELLKEDASIEIELLQHLKVACACLDDRHWKRPTMIQVM 1157 Query: 552 LM 557 M Sbjct: 1158 AM 1159
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 120 bits (300), Expect = 4e-27 Identities = 66/169 (39%), Positives = 101/169 (59%), Gaps = 1/169 (0%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L W R +I G A+GLLYLHE I+HRDIK+SN+LLDE N ++DFG+ARL Sbjct: 829 LKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPY 888 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 THV+T + GT GY+ PEY + K DV+SFG+++LE+++ ++ +D DL Sbjct: 889 ETHVST-DLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKRPVDMCKPKGCRDL 947 Query: 390 LNYTWKLSEEGRSLEIVDPGL-SGWDAGEVGMCVQLGLLCCQAVVSERP 533 +++ K+ E R+ E+ DP + S + E+ +++ LC +RP Sbjct: 948 ISWVVKMKHESRASEVFDPLIYSKENDKEMFRVLEIACLCLSENPKQRP 996
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 119 bits (297), Expect = 9e-27 Identities = 67/176 (38%), Positives = 108/176 (61%), Gaps = 3/176 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF-LE 206 L W R ++ LG A+GL +LH S ++I+RD K SN+LLD + N K+SDFG+A+ + Sbjct: 173 LSWKLRLKVALGAAKGLAFLHS-SETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIG 231 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVD 386 D +HV+T R+ GT+GY APEY G+L+TK+DV+SFG+++LE++SGR+ +D++ + + Sbjct: 232 DKSHVST-RVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRRAVDKNRPSGERN 290 Query: 387 LLNYTWK-LSEEGRSLEIVDPGLSG-WDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 L+ + L + + ++D L + E L L C + RP+M V Sbjct: 291 LVEWAKPYLVNKRKIFRVIDNRLQDQYSMEEACKVATLSLRCLTTEIKLRPNMSEV 346
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 118 bits (296), Expect = 1e-26 Identities = 69/176 (39%), Positives = 105/176 (59%), Gaps = 3/176 (1%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF-LE 206 L W R ++ LG A+GL +LH + +I+RD K SN+LLD + N K+SDFG+A+ Sbjct: 174 LSWTLRLKVALGAAKGLAFLHN-AETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTG 232 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVD 386 D +HV+T RI GTYGY APEY G+L+TK+DV+S+G+++LE++SGR+ +D++ + Sbjct: 233 DKSHVST-RIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRRAVDKNRPPGEQK 291 Query: 387 LLNYTWKLSEEGRSL-EIVDPGLSG-WDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 L+ + L R L ++D L + E L L C + RP+M V Sbjct: 292 LVEWARPLLANKRKLFRVIDNRLQDQYSMEEACKVATLALRCLTFEIKLRPNMNEV 347
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 116 bits (291), Expect = 4e-26 Identities = 70/182 (38%), Positives = 106/182 (58%), Gaps = 4/182 (2%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 V+L+W R +I +G ARGL +LH IIHRD+K+SNVLLDE L ++SDFGMARL Sbjct: 976 VKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMS 1035 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDR-HLGDEK 380 TH++ ++GT GY+ PEY + STK DV+S+G+++LE+++G++ D GD Sbjct: 1036 AMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN- 1094 Query: 381 VDLLNYTWKLSEEGRSLEIVDPGLSGWDAG---EVGMCVQLGLLCCQAVVSERPDMYSVH 551 +L+ + K + R ++ DP L D E+ +++ + C RP M V Sbjct: 1095 -NLVGWV-KQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 1152 Query: 552 LM 557 M Sbjct: 1153 AM 1154
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 115 bits (288), Expect = 9e-26 Identities = 73/175 (41%), Positives = 102/175 (58%), Gaps = 4/175 (2%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 W R +I++G ARGL +LH ++I+RD KASN+LLD + K+SDFG+A+L D Sbjct: 190 WDLRIKIVIGAARGLAFLHSLQR-EVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEK 248 Query: 216 HVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG--RKNIDRHLGDEK-VD 386 T RI GTYGY APEY G+L K+DVF+FG+++LEI++G N R G E VD Sbjct: 249 SHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTKRPRGQESLVD 308 Query: 387 LLNYTWKLSEEGRSLEIVDPGLSGWDAGEVGM-CVQLGLLCCQAVVSERPDMYSV 548 L +LS + R +I+D G+ G +V ++ L C + RP M V Sbjct: 309 WLRP--ELSNKHRVKQIMDKGIKGQYTTKVATEMARITLSCIEPDPKNRPHMKEV 361
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 114 bits (284), Expect = 3e-25 Identities = 65/169 (38%), Positives = 97/169 (57%), Gaps = 1/169 (0%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 LDW R +I G A GL YLH+ I+HRDIK+SN+LL + ++DFG+ARL L Sbjct: 838 LDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPY 897 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 THV T + GT GY+ PEY + K DV+SFG+++LE+++GR+ +D DL Sbjct: 898 DTHVTT-DLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTGRRPMDVCKPRGSRDL 956 Query: 390 LNYTWKLSEEGRSLEIVDPGLSGWD-AGEVGMCVQLGLLCCQAVVSERP 533 +++ ++ E R EI DP + D A E+ + +++ C RP Sbjct: 957 ISWVLQMKTEKRESEIFDPFIYDKDHAEEMLLVLEIACRCLGENPKTRP 1005
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 111 bits (277), Expect = 2e-24 Identities = 68/178 (38%), Positives = 104/178 (58%), Gaps = 1/178 (0%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L W R +I G A G+ +LHE IHRDIK++N+LLDE KISDFG+AR + Sbjct: 283 LSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKF 339 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 A V T RI GT YMAPE A+ G ++ K+D++SFG+++LEI++G +D H E L Sbjct: 340 AQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSFGVVLLEIITGLPAVDEH--REPQLL 396 Query: 390 LNYTWKLSEEGRSLE-IVDPGLSGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLML 560 L+ ++ +E +++E +D ++ D+ V + C ++RPD+ V +L Sbjct: 397 LDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLL 454
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 110 bits (274), Expect = 4e-24 Identities = 66/175 (37%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +3 Query: 27 QLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 +L+W +R I + ARG+ YLH + +IHRDIK+SN+L+DE N +++DFG++ L Sbjct: 602 RLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPA 661 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVD 386 D+ + +GT GY+ PEY YL+TK+DV+SFG+++LEI+SGRK ID E+ + Sbjct: 662 DSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQF--EEGN 719 Query: 387 LLNYTWKLSEEGRSLEIVDPGLS-GWDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 ++ + L + G I+DP LS D + + C + +RP M V Sbjct: 720 IVEWAVPLIKAGDIFAILDPVLSPPSDLEALKKIASVACKCVRMRGKDRPSMDKV 774
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 107 bits (267), Expect = 3e-23 Identities = 61/184 (33%), Positives = 103/184 (55%), Gaps = 1/184 (0%) Frame = +3 Query: 12 GXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMA 191 G + L W +R +I L A+GL YLH I+HRD+K +N+LL+EKL K++DFG++ Sbjct: 660 GKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLS 719 Query: 192 RLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLG 371 R F + + + ++G+ GY+ PEY ++ K+DV+S G+++LE+++G+ I Sbjct: 720 RSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQPAI-ASSK 778 Query: 372 DEKVDLLNYTWKLSEEGRSLEIVDPGL-SGWDAGEVGMCVQLGLLCCQAVVSERPDMYSV 548 EKV + ++ + G IVD L +D G ++ L C + ++RP M V Sbjct: 779 TEKVHISDHVRSILANGDIRGIVDQRLRERYDVGSAWKMSEIALACTEHTSAQRPTMSQV 838 Query: 549 HLML 560 + L Sbjct: 839 VMEL 842
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 106 bits (265), Expect = 4e-23 Identities = 68/180 (37%), Positives = 103/180 (57%), Gaps = 7/180 (3%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMAR---LF 200 L W +R I LG ARG+ +LH +IH DIK +N+LLD+ L PKI DFG+ R Sbjct: 315 LTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKS 374 Query: 201 LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDE- 377 L+ VN ++ GT Y+ PE+ LST DV+SFG+++LE+ +GR+ DR +E Sbjct: 375 LDAVVEVN--KVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENET 432 Query: 378 KVDLLNYTWKLSEEGRSLEIVDPGLSGWDAGEVGMC---VQLGLLCCQAVVSERPDMYSV 548 K +LL+Y + + R +E+++ L+ E+ MC ++ GL C +RP M +V Sbjct: 433 KKNLLDYVKQQWRQNR-MELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAV 491
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 105 bits (262), Expect = 1e-22 Identities = 66/182 (36%), Positives = 100/182 (54%), Gaps = 1/182 (0%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L W R ++ G A G+ +LHE IHRDIK++N+LLD+ KISDFG+AR Sbjct: 283 LSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASARL 339 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 A V T RI GT YMAPE A+ G ++ K+D++SFG+++LE+++G +D + E L Sbjct: 340 AQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSFGVVLLELITGLAAVDEN--REPQLL 396 Query: 390 LNYTWKLSEEGRSLE-IVDPGLSGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLMLSS 566 L+ ++ +E +++E D +S D V C + RPD+ V +L Sbjct: 397 LDIKEEIEDEEKTIEDYTDEKMSDADPASVEAMYSAASQCLHEKKNRRPDIAKVQQLLQE 456 Query: 567 DS 572 S Sbjct: 457 MS 458
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 103 bits (258), Expect = 3e-22 Identities = 64/192 (33%), Positives = 105/192 (54%), Gaps = 10/192 (5%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 + LDW R I LG+A+GL YLH E +IH D+K N+LLD+ PKI+DFG+ +L Sbjct: 625 ILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLN 684 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKV 383 + N + GT GY+APE+ + ++ K DV+S+G+++LE+++G + + G ++V Sbjct: 685 RGGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTRVSELVGGTDEV 744 Query: 384 D--LLNYTWKLSE--EGRSLEIVDPGLSG-----WDAGEVGMCVQLGLLCCQAVVSERPD 536 L LS EG +D L + + ++L + C + S+RP Sbjct: 745 HSMLRKLVRMLSAKLEGEEQSWIDGYLDSKLNRPVNYVQARTLIKLAVSCLEEDRSKRPT 804 Query: 537 M-YSVHLMLSSD 569 M ++V +LS+D Sbjct: 805 MEHAVQTLLSAD 816
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 103 bits (257), Expect = 4e-22 Identities = 52/119 (43%), Positives = 75/119 (63%), Gaps = 7/119 (5%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF--- 200 L WP+R I+LG AR + +LH++SP +IH DIK+SNVLLDE+L PK+ DFG+AR Sbjct: 310 LSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFA 368 Query: 201 ----LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRH 365 + + T + GT Y+ EY G L+ TD FSFG++VLE ++G++ + H Sbjct: 369 GSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 102 bits (255), Expect = 6e-22 Identities = 51/116 (43%), Positives = 75/116 (64%), Gaps = 7/116 (6%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL---- 197 L WP+R I+LG AR + +LH++SP +IH DIK+SNVLLDE+L PK+ DFG+AR Sbjct: 310 LSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFA 368 Query: 198 ---FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNI 356 + +T T + GT Y+ EY G L+ TD FSFG+++LE ++G++ + Sbjct: 369 GAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAV 424
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 92.4 bits (228), Expect = 9e-19 Identities = 58/182 (31%), Positives = 100/182 (54%), Gaps = 5/182 (2%) Frame = +3 Query: 18 KRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL 197 ++ L+W +RH+I LG+ARGL YLH V IIH +I++ NVL+D+ ++++FG+ ++ Sbjct: 465 RKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKI 524 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK-NIDRHLGD 374 ++ A + + GY APE + ++DV++FG+L+LEI+ G+K G+ Sbjct: 525 MVQ-AVADEIVSQAKSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKPGKSGRNGN 583 Query: 375 EKVDLLNYTWKLSEEGRSLEIVD----PGLSGWDAGEVGMCVQLGLLCCQAVVSERPDMY 542 E VDL + E ++E+ D G+ + ++L + CC V + RP M Sbjct: 584 EFVDLPSLVKAAVLEETTMEVFDLEAMKGIRSPMEEGLVHALKLAMGCCAPVTTVRPSME 643 Query: 543 SV 548 V Sbjct: 644 EV 645
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 83.2 bits (204), Expect = 5e-16 Identities = 48/144 (33%), Positives = 80/144 (55%), Gaps = 5/144 (3%) Frame = +3 Query: 3 CSTGXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDF 182 C+ G L W R +++G+A+ + YLH P +I ++ ++N+LLD++L PK++DF Sbjct: 268 CTNGT--TPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDF 325 Query: 183 GMARLFLEDATHVNTFRISG----TYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 A +T ++G YM EY G LS KTDV+SFG++++E+++G K Sbjct: 326 AAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCK 385 Query: 351 NIDRHLGDEK-VDLLNYTWKLSEE 419 + L D K V L + +L E+ Sbjct: 386 VV---LDDPKHVQLRDLLMELMEK 406
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 80.1 bits (196), Expect = 4e-15 Identities = 44/101 (43%), Positives = 69/101 (68%), Gaps = 8/101 (7%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNP--------KISDFGMARLFLEDATHV 221 +ARG+LYLHEE+ V I+HRD+K+SN+LL EK+ KI+DFG+AR + T + Sbjct: 244 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-HRTTKM 302 Query: 222 NTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 +T +GTY +MAPE + S +D++S+G+L+ E+++G Sbjct: 303 ST---AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTG 340
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 79.0 bits (193), Expect = 1e-14 Identities = 43/109 (39%), Positives = 69/109 (63%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 +++ + + +++ G A G+ YLH +P+ I+HRDIK +N+L+DE N KI+DFG AR+ Sbjct: 1455 IKITFANKLKLLYGAAMGIDYLHSSNPM-IVHRDIKPANILVDEHFNVKIADFGFARI-K 1512 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 ED T T GT + APE K DVFSFG+++ E+++G++ Sbjct: 1513 EDNT---TMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKE 1558 Score = 57.4 bits (137), Expect = 3e-08 Identities = 34/96 (35%), Positives = 57/96 (59%), Gaps = 5/96 (5%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 ++G+ +LH I+HRD+K+ N+LLD K N K+SDFG+ ++ E I GT Sbjct: 893 SKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTI 949 Query: 249 GYMAPEYAMNGYLSTK-----TDVFSFGMLVLEIVS 341 ++APE + ST+ DV+SFG+++ E+++ Sbjct: 950 HWIAPEILND---STEVDYILADVYSFGIILWELLT 982
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 78.6 bits (192), Expect = 1e-14 Identities = 40/107 (37%), Positives = 69/107 (64%), Gaps = 2/107 (1%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 WP +++ + G+ YLH+++PV ++HRD+K SNVL D +L+ K++DFG++ + Sbjct: 114 WPLLCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQS 172 Query: 216 HVNTFRISGTYGYMAPE--YAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 + GT GY+APE +N ST +DV+SFG+L+ +++GR+ Sbjct: 173 GTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE 219
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 78.6 bits (192), Expect = 1e-14 Identities = 41/109 (37%), Positives = 64/109 (58%), Gaps = 4/109 (3%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMA----RL 197 L W R I++G+++ + YLH P +I I ++N+LLD++ PK++DF MA L Sbjct: 262 LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHL 321 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 + T T S YM EY G LS KTDV+SFG++++E+++G Sbjct: 322 EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 76.6 bits (187), Expect = 5e-14 Identities = 40/107 (37%), Positives = 71/107 (66%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R QLD +R + +A+G+ YLH +P I+HRD+K+ N+L+D+K K+ DFG++R Sbjct: 643 REQLDERRRLSMAYDVAKGMNYLHNRNP-PIVHRDLKSPNLLVDKKYTVKVCDFGLSR-- 699 Query: 201 LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 L+ +T +++ +GT +MAPE + + K+DV+SFG+++ E+ + Sbjct: 700 LKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELAT 746
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 76.3 bits (186), Expect = 6e-14 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +3 Query: 57 ILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRI 236 +L + L Y+H ++HRD+K SN+++D+ ++ DFG+A+ +DA ++ Sbjct: 225 MLQICEALAYIHGHG---LVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKL 281 Query: 237 SGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 GTY YMAPE + L + D++S G+++ E++SGR D Sbjct: 282 VGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFD 322
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 74.7 bits (182), Expect = 2e-13 Identities = 44/103 (42%), Positives = 64/103 (62%), Gaps = 10/103 (9%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNP--------KISDFGMARLFLEDATHV 221 +ARG+ YLH E+P+ IIHRD+K+SNVL+ E + KI+DFG+AR Sbjct: 245 IARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR------EMY 298 Query: 222 NTFRIS--GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 NT R+S GTY +M PE S +DV+S+G+L+ E+++G Sbjct: 299 NTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITG 341
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 73.6 bits (179), Expect = 4e-13 Identities = 40/101 (39%), Positives = 63/101 (62%), Gaps = 8/101 (7%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNP--------KISDFGMARLFLEDATHV 221 +ARG+ YLH+E+ V IIHRD+K+SN+L+ +K+ KI+DFG+AR + Sbjct: 249 IARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR----EWHRT 304 Query: 222 NTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 +GTY +MAPE S +DV+S+G+L+ E+++G Sbjct: 305 TKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTG 345
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 73.6 bits (179), Expect = 4e-13 Identities = 42/102 (41%), Positives = 63/102 (61%), Gaps = 9/102 (8%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNP--------KISDFGMARLFLEDATHV 221 +ARG+ YLH ++PV IIHRD+K+ N+L+ E + KI+DFG+AR + H Sbjct: 203 VARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW-----HK 257 Query: 222 NT-FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 T +GTY +MAPE S +DV+SFG+L+ E+++G Sbjct: 258 TTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTG 299
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 71.2 bits (173), Expect = 2e-12 Identities = 40/108 (37%), Positives = 66/108 (61%), Gaps = 3/108 (2%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL--FLED 209 WP +++ + G+ YLH +P ++HRD+K SNVLLD +L+ K++DFG++ + Sbjct: 115 WPLLCRLLEEVVLGMCYLHSLNP-SLLHRDLKPSNVLLDLELHAKLADFGLSTFQGGSQS 173 Query: 210 ATHVNTFRISGTYGYMAPEYAMN-GYLSTKTDVFSFGMLVLEIVSGRK 350 + + GT Y+APE N G S +DV+SFG+LV +++GR+ Sbjct: 174 GSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGRE 221
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 70.5 bits (171), Expect = 3e-12 Identities = 43/116 (37%), Positives = 69/116 (59%), Gaps = 3/116 (2%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R+ +DW G+A G+ YLH KIIHRD+K+ NVL+ KISDFG ++ Sbjct: 254 RLLVDWST------GIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKEL 304 Query: 201 LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR---KNID 359 + +T ++ +GT +MAPE N +S K D++SFG+++ E+++G K++D Sbjct: 305 SDKSTKMS---FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 357
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 70.1 bits (170), Expect = 5e-12 Identities = 42/124 (33%), Positives = 73/124 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A+G+ YLH E+PVK+IHRD+K+ NV++ KI DFG +R F TH++ + GT Sbjct: 114 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMS---LVGT 169 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWKLSEEGR 425 + +MAPE + +S D +S+G+++ E+++ R + + ++ L W + E+ Sbjct: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT------REVPFKGLEGLQVAWLVVEKNE 223 Query: 426 SLEI 437 L I Sbjct: 224 RLTI 227
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 70.1 bits (170), Expect = 5e-12 Identities = 42/124 (33%), Positives = 73/124 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A+G+ YLH E+PVK+IHRD+K+ NV++ KI DFG +R F TH++ + GT Sbjct: 114 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMS---LVGT 169 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWKLSEEGR 425 + +MAPE + +S D +S+G+++ E+++ R + + ++ L W + E+ Sbjct: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT------REVPFKGLEGLQVAWLVVEKNE 223 Query: 426 SLEI 437 L I Sbjct: 224 RLTI 227
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 70.1 bits (170), Expect = 5e-12 Identities = 42/128 (32%), Positives = 71/128 (55%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I + + RGL YL +E +KI+HRD+K SN+L++ K+ DFG++ + ++ N+F Sbjct: 173 RISVAVVRGLTYLKDE--IKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMA--NSF 228 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWKL 410 GT YMAPE + + +D++SFG+ ++E++ GR + E + N Sbjct: 229 --VGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENE 286 Query: 411 SEEGRSLE 434 E SLE Sbjct: 287 IELADSLE 294
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 69.7 bits (169), Expect = 6e-12 Identities = 40/112 (35%), Positives = 66/112 (58%), Gaps = 2/112 (1%) Frame = +3 Query: 18 KRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL 197 KR QL P+ +++ + L Y+H++ ++IHRD+K N++LDE N KI DFG+A L Sbjct: 131 KRKQLTEPEVRYLMMQILGALKYMHKK---RVIHRDLKLGNIMLDESNNVKIGDFGLAAL 187 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGY--LSTKTDVFSFGMLVLEIVSGR 347 ++D T I GT Y+APE N S + D++S G+++ ++ G+ Sbjct: 188 LMDDEERKMT--ICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGK 237
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 69.7 bits (169), Expect = 6e-12 Identities = 41/112 (36%), Positives = 66/112 (58%), Gaps = 13/112 (11%) Frame = +3 Query: 45 RHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPK-------------ISDFG 185 R ++ L +A+G+ YLH +P I+HRD+ + N+LLD ++PK ISDFG Sbjct: 1392 RLKLALDIAKGMNYLHGWTP-PILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFG 1450 Query: 186 MARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 ++RL E A+ + + G YMAPE S K+DV+S+GM++ E+++ Sbjct: 1451 LSRLKKEQASQMT--QSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLT 1500
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 69.7 bits (169), Expect = 6e-12 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 12/123 (9%) Frame = +3 Query: 27 QLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 Q W +R +A G+ YLH + IIHRD+ + N L+ E N ++DFG+ARL ++ Sbjct: 431 QYPWSQRVSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENKNVVVADFGLARLMVD 487 Query: 207 DATHVNTFR------------ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 + T R + G +MAPE K DVFSFG+++ EI+ GR Sbjct: 488 EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRV 546 Query: 351 NID 359 N D Sbjct: 547 NAD 549
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 69.7 bits (169), Expect = 6e-12 Identities = 41/102 (40%), Positives = 63/102 (61%), Gaps = 9/102 (8%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNP--------KISDFGMARLFLEDATHV 221 +ARG+ YLH E+ V +IHRD+K++N+LL + + KI+DFG+AR + H Sbjct: 222 IARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREW-----HK 276 Query: 222 NT-FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 T +GTY +MAPE S +DV+SFG+L+ E+++G Sbjct: 277 TTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTG 318
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 69.3 bits (168), Expect = 8e-12 Identities = 42/101 (41%), Positives = 58/101 (57%), Gaps = 1/101 (0%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 + +GL YLH E K IHRDIKA+NVLL E+ + K++DFG+A + NTF GT Sbjct: 128 ILKGLDYLHSE---KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF--VGT 182 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR-KNIDRH 365 +MAPE +K D++S G+ +E+ G N D H Sbjct: 183 PFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMH 223
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 69.3 bits (168), Expect = 8e-12 Identities = 42/101 (41%), Positives = 58/101 (57%), Gaps = 1/101 (0%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 + +GL YLH E K IHRDIKA+NVLL E+ + K++DFG+A + NTF GT Sbjct: 128 ILKGLDYLHSE---KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF--VGT 182 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR-KNIDRH 365 +MAPE +K D++S G+ +E+ G N D H Sbjct: 183 PFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMH 223
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 69.3 bits (168), Expect = 8e-12 Identities = 41/99 (41%), Positives = 56/99 (56%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I + RGL YLHE K+IHRDIK N+LL+EK K+ DFG++ +A + Sbjct: 321 KIAESVLRGLSYLHER---KVIHRDIKPQNILLNEKGEIKLCDFGVS----GEAVNSLAM 373 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +GT YMAPE S DV+S G+ +LE+ GR Sbjct: 374 TFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGR 412
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 69.3 bits (168), Expect = 8e-12 Identities = 42/116 (36%), Positives = 69/116 (59%), Gaps = 3/116 (2%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R+ +DW G+A G+ YLH KIIHRD+K+ NVL+ KISDFG ++ Sbjct: 254 RLLVDWST------GIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKEL 304 Query: 201 LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR---KNID 359 + +T ++ +GT ++APE N +S K D++SFG+++ E+++G K++D Sbjct: 305 SDKSTKMS---FAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 357
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 68.9 bits (167), Expect = 1e-11 Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 21/150 (14%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 PK +A G+ Y+ ++ IHRD++A+NVL+ E L KI+DFG+AR+ +ED + Sbjct: 341 PKLIDFSAQIAEGMAYIERKN---YIHRDLRAANVLVSESLMCKIADFGLARV-IEDNEY 396 Query: 219 VNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS-------GRKNID------ 359 + APE G + K+DV+SFG+L+ EIV+ GR N D Sbjct: 397 TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALS 456 Query: 360 --------RHLGDEKVDLLNYTWKLSEEGR 425 + DE D++ WK S E R Sbjct: 457 QGYRMPRMENCPDELYDIMKMCWKESAEER 486
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 68.6 bits (166), Expect = 1e-11 Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 12/123 (9%) Frame = +3 Query: 27 QLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 Q W +R +A G+ YLH + IIHRD+ + N L+ E N ++DFG+ARL ++ Sbjct: 431 QYPWSQRVSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENRNVVVADFGLARLMID 487 Query: 207 DATHVNTFR------------ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 + R + G +MAPE K DVFSFG+++ EI+ GR Sbjct: 488 EKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRV 546 Query: 351 NID 359 N D Sbjct: 547 NAD 549
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 68.2 bits (165), Expect = 2e-11 Identities = 39/99 (39%), Positives = 58/99 (58%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I + RGL YLHE+ K+IHRDIK N+LL+E K+ DFG++ +A + Sbjct: 328 KIAEAVLRGLSYLHEK---KVIHRDIKPQNILLNENGQVKLCDFGVS----GEAVNSLAT 380 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +GT YMAPE S +DV+S G+ +LE+ +G+ Sbjct: 381 TFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGK 419
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/179 (29%), Positives = 88/179 (49%), Gaps = 3/179 (1%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED--ATHVN 224 Q++LG+ L Y H + IIHRDIK N+++ E+ K+ DFG+AR L+D AT Sbjct: 125 QVMLGVLNALDYSHR---MGIIHRDIKPGNIMISEQGVVKVMDFGIARA-LDDSAATMTQ 180 Query: 225 TFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTW 404 + + GT Y++PE A + ++D++S G ++ E+++GR GD V + Sbjct: 181 SQGVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYEMLTGRPPF---TGDSAVAIAYQ-- 235 Query: 405 KLSEEGRSLEIVDPGL-SGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLMLSSDSFT 578 +SE PGL WD+ +C +A+ +R + Y+ +D T Sbjct: 236 HVSEVATPPSAAVPGLPKMWDS-----------ICAKAMAKDRQNRYATASEFKTDILT 283
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 67.8 bits (164), Expect = 2e-11 Identities = 39/103 (37%), Positives = 65/103 (63%), Gaps = 3/103 (2%) Frame = +3 Query: 60 LGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRIS 239 +G+A G+ YLH KIIHRD+K+ N+L+ KISDFG ++ + +T ++ + Sbjct: 218 MGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS---FA 271 Query: 240 GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR---KNID 359 GT +MAPE N +S K D++SFG+++ E+++G K++D Sbjct: 272 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 314
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 67.8 bits (164), Expect = 2e-11 Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 12/123 (9%) Frame = +3 Query: 27 QLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 Q W +R +A G+ YLH + IIHRD+ + N L+ E N ++DFG+ARL ++ Sbjct: 431 QYPWSQRVSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENRNVVVADFGLARLMID 487 Query: 207 DATHVNTFR------------ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 + R + G +MAPE K DVFSFG+++ EI+ GR Sbjct: 488 EKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRV 546 Query: 351 NID 359 N D Sbjct: 547 NAD 549
>STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC 2.7.12.2)| Length = 515 Score = 67.8 bits (164), Expect = 2e-11 Identities = 40/105 (38%), Positives = 62/105 (59%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I G+ GL +L+ + KIIHRDIK SNVL++ K K+ DFG+++ + +TF Sbjct: 309 KIAYGVLNGLDHLYRQ--YKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSI--ADTF 364 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRH 365 GT YM+PE S K DV+S G++++E+V+G + H Sbjct: 365 --VGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGH 407
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 67.8 bits (164), Expect = 2e-11 Identities = 39/103 (37%), Positives = 65/103 (63%), Gaps = 3/103 (2%) Frame = +3 Query: 60 LGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRIS 239 +G+A G+ YLH KIIHRD+K+ N+L+ KISDFG ++ + +T ++ + Sbjct: 251 MGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS---FA 304 Query: 240 GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR---KNID 359 GT +MAPE N +S K D++SFG+++ E+++G K++D Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 347
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 67.8 bits (164), Expect = 2e-11 Identities = 39/103 (37%), Positives = 65/103 (63%), Gaps = 3/103 (2%) Frame = +3 Query: 60 LGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRIS 239 +G+A G+ YLH KIIHRD+K+ N+L+ KISDFG ++ + +T ++ + Sbjct: 251 MGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS---FA 304 Query: 240 GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR---KNID 359 GT +MAPE N +S K D++SFG+++ E+++G K++D Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 347
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 67.4 bits (163), Expect = 3e-11 Identities = 49/150 (32%), Positives = 73/150 (48%), Gaps = 21/150 (14%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 PK +A G+ Y+ ++ IHRD++A+NVL+ E L KI+DFG+AR+ +ED + Sbjct: 341 PKLIDFSAQIAEGMAYIERKN---YIHRDLRAANVLVSESLMCKIADFGLARV-IEDNEY 396 Query: 219 VNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS-------GRKNID------ 359 + APE G + K+DV+SFG+L+ EIV+ GR N D Sbjct: 397 TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALS 456 Query: 360 --------RHLGDEKVDLLNYTWKLSEEGR 425 + DE D++ WK E R Sbjct: 457 QGYRMPRMENCPDELYDIMKMCWKEKAEER 486
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 67.4 bits (163), Expect = 3e-11 Identities = 49/150 (32%), Positives = 73/150 (48%), Gaps = 21/150 (14%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 PK +A G+ Y+ ++ IHRD++A+NVL+ E L KI+DFG+AR+ +ED + Sbjct: 341 PKLIDFSAQIAEGMAYIERKN---YIHRDLRAANVLVSESLMCKIADFGLARV-IEDNEY 396 Query: 219 VNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS-------GRKNID------ 359 + APE G + K+DV+SFG+L+ EIV+ GR N D Sbjct: 397 TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALS 456 Query: 360 --------RHLGDEKVDLLNYTWKLSEEGR 425 + DE D++ WK E R Sbjct: 457 QGYRMPRVENCPDELYDIMKMCWKEKAEER 486
>STK25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 67.0 bits (162), Expect = 4e-11 Identities = 42/105 (40%), Positives = 59/105 (56%), Gaps = 1/105 (0%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 I+ + +GL YLH E + IHRDIKA+NVLL E+ + K++DFG+A + NTF Sbjct: 120 ILREILKGLDYLHSE---RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF- 175 Query: 234 ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR-KNIDRH 365 GT +MAPE K D++S G+ +E+ G N D H Sbjct: 176 -VGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLH 219
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 67.0 bits (162), Expect = 4e-11 Identities = 42/105 (40%), Positives = 58/105 (55%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 LD + I+ + +GL YLH E K IHRDIKA+NVLL E K++DFG+A + Sbjct: 128 LDETQIATILREILKGLDYLHSE---KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDT 184 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 NTF GT +MAPE +K D++S G+ +E+ G Sbjct: 185 QIKRNTF--VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARG 227
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 67.0 bits (162), Expect = 4e-11 Identities = 38/97 (39%), Positives = 57/97 (58%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 Q L +A G+ YL + K++HRD+ A N+L+ E L K+SDFG+A+ L + Sbjct: 290 QFALHVAEGMEYLESK---KLVHRDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSRL 346 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + T APE NG S+K+DV+SFG+L+ E+ S Sbjct: 347 PVKWT----APEALKNGRFSSKSDVWSFGVLLWEVFS 379
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 67.0 bits (162), Expect = 4e-11 Identities = 40/97 (41%), Positives = 55/97 (56%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 I+ + +GL YLH E K IHRDIKA+NVLL E K++DFG+A + NTF Sbjct: 124 ILREILKGLDYLHSE---KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTF- 179 Query: 234 ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 GT +MAPE +K D++S G+ +E+ G Sbjct: 180 -VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKG 215
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 66.6 bits (161), Expect = 5e-11 Identities = 31/84 (36%), Positives = 54/84 (64%) Frame = +3 Query: 108 KIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYL 287 +I+HRDIK N+L+D N K++DFG+A L T +T + G+ Y++PE A G Sbjct: 129 QIVHRDIKPHNILIDHMGNIKVTDFGIATA-LSSTTITHTNSVLGSVHYLSPEQARGGLA 187 Query: 288 STKTDVFSFGMLVLEIVSGRKNID 359 + K+D+++ G+++ E+++GR D Sbjct: 188 TKKSDIYALGIVLFELLTGRIPFD 211
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 66.6 bits (161), Expect = 5e-11 Identities = 42/105 (40%), Positives = 59/105 (56%), Gaps = 1/105 (0%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 I+ + +GL YLH E + IHRDIKA+NVLL E+ + K++DFG+A + NTF Sbjct: 120 ILREILKGLDYLHSE---RKIHRDIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTF- 175 Query: 234 ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR-KNIDRH 365 GT +MAPE K D++S G+ +E+ G N D H Sbjct: 176 -VGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLH 219
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 66.2 bits (160), Expect = 7e-11 Identities = 35/111 (31%), Positives = 66/111 (59%), Gaps = 6/111 (5%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 WP R +I+ +A G+ YLH +P ++H D+K N+LLD + + KI+DFG+++ + + Sbjct: 118 WPLRFRILHEIALGVNYLHNMNP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLS 176 Query: 216 HVNTFRIS---GTYGYMAPEYAMNGY---LSTKTDVFSFGMLVLEIVSGRK 350 +++ + GT YM PE G S K D++S+ +++ E++S ++ Sbjct: 177 QSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQ 227
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 66.2 bits (160), Expect = 7e-11 Identities = 38/92 (41%), Positives = 55/92 (59%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ YL ++ IHRD+ A N+L+ E K+ DFG+ARL ED + I Sbjct: 296 VAEGMCYLESQN---YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNI--P 350 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 Y + APE G+ STK+DV+SFG+L+ E+ S Sbjct: 351 YKWTAPEALSRGHYSTKSDVWSFGILLHEMFS 382
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 65.9 bits (159), Expect = 9e-11 Identities = 39/99 (39%), Positives = 56/99 (56%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I G+ GL YLH+ KIIHRDIK SN+LL K K+ DFG++ + TF Sbjct: 185 KIAFGVLSGLSYLHDR---KIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSL--AGTF 239 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +GT YMAPE G + +D++S G+ ++E+ R Sbjct: 240 --TGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNR 276
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 65.9 bits (159), Expect = 9e-11 Identities = 37/107 (34%), Positives = 59/107 (55%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R QL K + L + GLL+LH +S I+H D+K +N+L+ EK KISDFG ++ Sbjct: 165 REQLSLGKCLKYSLDIVNGLLFLHSQS---ILHLDLKPANILISEKDVCKISDFGCSQKL 221 Query: 201 LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + I GTY + APE + K D++SFG+ + ++ + Sbjct: 222 QDLRCRPSLHHIGGTYTHQAPELLKGEIATPKADIYSFGITLWQMTT 268
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 65.5 bits (158), Expect = 1e-10 Identities = 37/111 (33%), Positives = 64/111 (57%), Gaps = 6/111 (5%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARL----FL 203 WP +++ + G+ YLH P ++HRD+K SN+LLD +L+ K++DFG++ Sbjct: 115 WPLLCRLLQEVVLGMCYLHSLDP-PLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQS 173 Query: 204 EDATHVNTFRISGTYGYMAPE--YAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 + + GT Y+ PE + +N S +DV+SFG+LV +++GR+ Sbjct: 174 GSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 65.5 bits (158), Expect = 1e-10 Identities = 42/110 (38%), Positives = 64/110 (58%), Gaps = 2/110 (1%) Frame = +3 Query: 27 QLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 + D P + + +GL YLH + I+HRD+KA N+LLD+ KISDFG++R + Sbjct: 1274 RFDEPLIKHLTTQVLKGLAYLHSKG---ILHRDMKADNLLLDQDGICKISDFGISRK-SK 1329 Query: 207 DATHVNTFRISGTYGYMAPEY--AMNGYLSTKTDVFSFGMLVLEIVSGRK 350 D + + GT +MAPE GY S K D++S G +VLE+ +G++ Sbjct: 1330 DIYSNSDMTMRGTVFWMAPEMVDTKQGY-SAKVDIWSLGCIVLEMFAGKR 1378
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 65.5 bits (158), Expect = 1e-10 Identities = 37/93 (39%), Positives = 53/93 (56%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L GL YLH+ I HRD+K N+LLDE N KISDFGMA +F + GT Sbjct: 127 LLSGLNYLHQRG---IAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGT 183 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 Y+APE Y + D++S G++++ +++G Sbjct: 184 LPYVAPEVLQKAYHAQPADLWSCGVILVTMLAG 216
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 65.1 bits (157), Expect = 1e-10 Identities = 39/97 (40%), Positives = 59/97 (60%), Gaps = 3/97 (3%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF-LEDATHVNTFRISG 242 L + YLH E V HRDIK N+LLD+ N K++DFG+A F +D T + G Sbjct: 125 LVSAINYLHVECGVA--HRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRG 182 Query: 243 TYGYMAPE--YAMNGYLSTKTDVFSFGMLVLEIVSGR 347 + YMAPE Y+ GY + +TD++S G+L+ +++G+ Sbjct: 183 SPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLLTGQ 219
>DAF4_CAEEL (P50488) Cell-surface receptor daf-4 precursor (EC 2.7.11.30)| (Abnormal dauer formation protein 4) Length = 744 Score = 65.1 bits (157), Expect = 1e-10 Identities = 38/113 (33%), Positives = 61/113 (53%), Gaps = 12/113 (10%) Frame = +3 Query: 48 HQIILGLARGLLYLHEESPV-------KIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 ++II+ + GL +LH++ P IIHRDIK+ N+L+ + I+DFG+AR++ Sbjct: 408 NRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSY 467 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKT-----DVFSFGMLVLEIVSGRK 350 D + GT YM+PE T T DV+S G+++ E++S K Sbjct: 468 DIEQSDLLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISRTK 520
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 64.7 bits (156), Expect = 2e-10 Identities = 37/104 (35%), Positives = 56/104 (53%) Frame = +3 Query: 48 HQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNT 227 HQII G+ LYLH I+HRD+ SN+LL +N KI+DFG+A + H Sbjct: 118 HQIITGM----LYLHSHG---ILHRDLTLSNILLTRNMNIKIADFGLATQL--NMPHEKH 168 Query: 228 FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 + + GT Y++PE A ++D++S G + ++ GR D Sbjct: 169 YTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFD 212
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 64.7 bits (156), Expect = 2e-10 Identities = 37/94 (39%), Positives = 55/94 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L GL YLH + I+HRDIK +N+L+D K K++DFG ++ E AT + GT Sbjct: 181 LLLGLEYLHNHA---IMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGT 237 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE + S D++S G V+E+V+G+ Sbjct: 238 PYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGK 271
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 64.3 bits (155), Expect = 2e-10 Identities = 36/111 (32%), Positives = 63/111 (56%), Gaps = 6/111 (5%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMAR---LFLE 206 WP R +I+ +A G+ YLH +P ++H D+K N+LLD + + KI+DFG+++ + L Sbjct: 118 WPLRFRILHEIALGVNYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLS 176 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGY---LSTKTDVFSFGMLVLEIVSGRK 350 + + GT YM PE G S K D++S+ ++ E++S ++ Sbjct: 177 QSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQ 227
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/95 (38%), Positives = 61/95 (64%), Gaps = 3/95 (3%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHV---NTFRI 236 +A G+ Y+ + IHRD++A+N+L+ E+L KI+DFG+ARL +D + + F I Sbjct: 366 VAEGMAYMER---MNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPI 422 Query: 237 SGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 T APE A+ G + K+DV+SFG+L+ E+++ Sbjct: 423 KWT----APEAALFGRFTIKSDVWSFGILLTELIT 453
>LRRK1_MOUSE (Q3UHC2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2014 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/105 (35%), Positives = 61/105 (58%), Gaps = 5/105 (4%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLL-----DEKLNPKISDFGMARLFLEDAT 215 +I +A GL YLH+++ II D+K+ N+L+ E +N K+SD+G++R + Sbjct: 1365 KIAYQIASGLAYLHKKN---IIFCDLKSDNILVWSLSAKEHINIKLSDYGISR----QSF 1417 Query: 216 HVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 H + GT GY APE K D+FS+GM++ E++SG++ Sbjct: 1418 HEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQR 1462
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 64.3 bits (155), Expect = 2e-10 Identities = 33/97 (34%), Positives = 60/97 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ L ++RG+ YLH + +IHRD+K++N+LL++++ K++DFG + L + Sbjct: 191 RLALDISRGMEYLHSQG---VIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNM 247 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 GTY +MAPE + K DV+SFG+++ E+ + Sbjct: 248 ---GTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTT 281
>LRRK1_HUMAN (Q38SD2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2038 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/105 (35%), Positives = 61/105 (58%), Gaps = 5/105 (4%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLL-----DEKLNPKISDFGMARLFLEDAT 215 +I +A GL YLH+++ II D+K+ N+L+ E +N K+SD+G++R + Sbjct: 1388 KIAYQIASGLAYLHKKN---IIFCDLKSDNILVWSLDVKEHINIKLSDYGISR----QSF 1440 Query: 216 HVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 H + GT GY APE K D+FS+GM++ E++SG++ Sbjct: 1441 HEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQR 1485
>GPRK1_DROME (P32865) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 700 Score = 64.3 bits (155), Expect = 2e-10 Identities = 38/116 (32%), Positives = 65/116 (56%), Gaps = 1/116 (0%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL ++H+ I++RD+K +N+LLDE + +ISD G+A F + H + GT+GY Sbjct: 305 GLEHMHKRC---IVYRDLKPANILLDENGHIRISDLGLACDFSKKKPHASV----GTHGY 357 Query: 255 MAPEYAMNG-YLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWKLSEE 419 MAPE G + D FSFG ++ +++ G +H +K+++ T ++ E Sbjct: 358 MAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDKLEIDKMTLTMNVE 413
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 64.3 bits (155), Expect = 2e-10 Identities = 38/104 (36%), Positives = 63/104 (60%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ E+L KI+DFG+ARL +ED Sbjct: 377 LTLPQLVDMAAQVAEGMAYMER---MDYIHRDLRAANILVGERLVCKIADFGLARL-IED 432 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L+ E++S Sbjct: 433 NEYNPRQGAKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELIS 476
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 63.9 bits (154), Expect = 3e-10 Identities = 37/106 (34%), Positives = 65/106 (61%) Frame = +3 Query: 24 VQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFL 203 ++L+ K + +A G+ ++ E++ IHRD++A+N+L+ + L+ KI+DFG+ARL + Sbjct: 333 IKLNVNKLLDMAAQIAEGMAFIEEQN---YIHRDLRAANILVSDTLSCKIADFGLARL-I 388 Query: 204 EDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 ED + + APE G + K+DV+SFG+L+ EIV+ Sbjct: 389 EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVT 434
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 63.9 bits (154), Expect = 3e-10 Identities = 36/107 (33%), Positives = 59/107 (55%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDFG ++ Sbjct: 167 REQLSLGKCLKYSLDVVNGLLFLHSQS---ILHLDLKPANILISEQDVCKISDFGCSQKL 223 Query: 201 LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + I GTY + APE + K D++SFG+ + ++ + Sbjct: 224 QDLRCRQSPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTT 270
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 63.9 bits (154), Expect = 3e-10 Identities = 34/99 (34%), Positives = 61/99 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + RGL YL E+ +I+HRD+K SN+L++ + K+ DFG++ ++ N+F Sbjct: 172 KVSIAVLRGLAYLREKH--QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSF 227 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YMAPE + S ++D++S G+ ++E+ GR Sbjct: 228 --VGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGR 264
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 63.9 bits (154), Expect = 3e-10 Identities = 34/99 (34%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + RGL+YL E+ +I+HRD+K SN+L++ + K+ DFG++ ++ N+F Sbjct: 169 KVSIAVLRGLVYLREKH--QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSF 224 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++DV+S G+ ++E+ GR Sbjct: 225 --VGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGR 261
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 63.5 bits (153), Expect = 4e-10 Identities = 37/97 (38%), Positives = 60/97 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 Q L +A G+ YL + K++HRD+ A N+L+ E L K+SDFG+A+ + +++ Sbjct: 329 QFALHVAEGMEYLESK---KLVHRDLAARNILVSEDLVAKVSDFGLAK---AERKGLDSS 382 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 R+ + APE NG S+K+DV+SFG+L+ E+ S Sbjct: 383 RL--PVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFS 417
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 63.5 bits (153), Expect = 4e-10 Identities = 38/104 (36%), Positives = 55/104 (52%) Frame = +3 Query: 48 HQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNT 227 HQII G+ LYLH I+HRD+ SN+LL +N KI+DFG+A H Sbjct: 118 HQIITGM----LYLHSHG---ILHRDLTLSNLLLTRNMNIKIADFGLATQL--KMPHEKH 168 Query: 228 FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 + + GT Y++PE A ++DV+S G + ++ GR D Sbjct: 169 YTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFD 212
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 63.5 bits (153), Expect = 4e-10 Identities = 36/96 (37%), Positives = 56/96 (58%), Gaps = 4/96 (4%) Frame = +3 Query: 72 RGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF----RIS 239 +GL YLH I+HRDIK +N+L+D K KISDFG+++ ++T T Sbjct: 508 KGLEYLHSRG---IVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQ 564 Query: 240 GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 G+ +MAPE + KTD++S G LV+E+++ + Sbjct: 565 GSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSK 600
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 63.5 bits (153), Expect = 4e-10 Identities = 38/92 (41%), Positives = 54/92 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ YL ++ IHRD+ A NVL+ E K+ DFG+ARL ED + + Sbjct: 296 VAEGMCYLESQN---YIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNV--P 350 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 Y + APE G+ S K+DV+SFG+L+ EI S Sbjct: 351 YKWTAPEALSRGHYSIKSDVWSFGVLLHEIFS 382
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 63.5 bits (153), Expect = 4e-10 Identities = 33/113 (29%), Positives = 60/113 (53%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I+ + L + H+ IIHRD+K +N+++ K+ DFG+AR + + T Sbjct: 117 EIVADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSTSVTQTA 173 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 + GT Y++PE A + ++DV+S G ++ EI++G +GD V + Sbjct: 174 AVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPPF---IGDSPVSV 223
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 63.2 bits (152), Expect = 6e-10 Identities = 38/104 (36%), Positives = 61/104 (58%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ E L KI+DFG+ARL +ED Sbjct: 365 LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLICKIADFGLARL-IED 420 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L E+V+ Sbjct: 421 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVT 464
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 63.2 bits (152), Expect = 6e-10 Identities = 37/104 (35%), Positives = 62/104 (59%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ + L KI+DFG+ARL +ED Sbjct: 365 LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARL-IED 420 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 421 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVT 464
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 63.2 bits (152), Expect = 6e-10 Identities = 39/97 (40%), Positives = 56/97 (57%), Gaps = 1/97 (1%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGM-ARLFLEDATHVNT 227 +I L +G+ +LH + IIHRDIK+ NVLLD N KI+DFG ARL V Sbjct: 413 RICLETCKGIQHLHARN---IIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVT- 468 Query: 228 FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIV 338 + GT +MAPE TK D++S G++++E++ Sbjct: 469 --MVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMI 503
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 63.2 bits (152), Expect = 6e-10 Identities = 38/103 (36%), Positives = 61/103 (59%), Gaps = 5/103 (4%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLN---PKISDFGMARLFLEDA-THVNTFR 233 LA GL +H++ IIHRD+K NV + + ++ DFG+ARL DA + V+ Sbjct: 119 LAEGLAAIHDKG---IIHRDLKPENVFISKSARGEQARLLDFGIARLVEPDAASSVSQIG 175 Query: 234 IS-GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 + GT Y++PE A+ + T++D++SFG+L ++SGR D Sbjct: 176 VVLGTPEYLSPEQAVGAKVDTRSDLYSFGVLTYRVLSGRLPFD 218
>KPC1_LYTPI (Q25378) Protein kinase C (EC 2.7.11.13)| Length = 658 Score = 63.2 bits (152), Expect = 6e-10 Identities = 37/104 (35%), Positives = 58/104 (55%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL YLH + +I+RD+K NVL+D + + KI+DFGM + + + TF GT Sbjct: 433 IAVGLFYLHSQG---VIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTF--CGT 487 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDE 377 Y+APE D ++FG+L+ E+++G+ D DE Sbjct: 488 PDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAGQPPFDGEDEDE 531
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 63.2 bits (152), Expect = 6e-10 Identities = 37/104 (35%), Positives = 62/104 (59%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ + L KI+DFG+ARL +ED Sbjct: 361 LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARL-IED 416 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVA 460
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 63.2 bits (152), Expect = 6e-10 Identities = 39/112 (34%), Positives = 65/112 (58%), Gaps = 8/112 (7%) Frame = +3 Query: 30 LDWPKRHQIILG--------LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFG 185 LD P + +G ++RG+ YL E +K++HRD+ A N+L+ E KISDFG Sbjct: 839 LDHPDERVLTMGDLISFAWQISRGMQYLAE---MKLVHRDLAARNILVAEGRKMKISDFG 895 Query: 186 MARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 ++R E+ ++V + +MA E + +T++DV+SFG+L+ EIV+ Sbjct: 896 LSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 947
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 63.2 bits (152), Expect = 6e-10 Identities = 38/104 (36%), Positives = 61/104 (58%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ E L KI+DFG+ARL +ED Sbjct: 367 LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLVCKIADFGLARL-IED 422 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L E+V+ Sbjct: 423 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVT 466
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 63.2 bits (152), Expect = 6e-10 Identities = 35/99 (35%), Positives = 59/99 (59%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I + R L + H+ KIIHRDIK N+L+ ++ K++DFG+AR AT T Sbjct: 113 EIASQVCRALDHAHKN---KIIHRDIKPQNILVTDEDVVKVTDFGIARA-ANGATITYTG 168 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 + GT Y +PE A + +TD++S G+++ E+++G+ Sbjct: 169 DVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGK 207
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 63.2 bits (152), Expect = 6e-10 Identities = 37/104 (35%), Positives = 62/104 (59%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ + L KI+DFG+ARL +ED Sbjct: 360 LKLPQLVDMAAQIAAGMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARL-IED 415 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 416 NEYTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTELVT 459
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 63.2 bits (152), Expect = 6e-10 Identities = 37/104 (35%), Positives = 62/104 (59%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ + L KI+DFG+ARL +ED Sbjct: 358 LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARL-IED 413 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 414 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVT 457
>IKKB_DROME (Q9VEZ5) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.1) (DmIKK-beta) (Immune response deficient protein 5) (IKK-like protein) (Lipopolysaccharide-activated kinase) (DLAK) (Cactus kinase IKK) Length = 751 Score = 62.8 bits (151), Expect = 7e-10 Identities = 44/127 (34%), Positives = 68/127 (53%), Gaps = 13/127 (10%) Frame = +3 Query: 3 CSTGXKRVQLDWPKR---------HQIILGLARGLLYLHEESPVKIIHRDIKASNVLL-- 149 C+ G R +L P+ QI+ L + L +LH S I HRD+K N+++ Sbjct: 137 CNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLH--SQCGICHRDLKPDNIVIQR 194 Query: 150 --DEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGML 323 D K K++DFG+AR D T V + + GT Y APE NG+ ++ D++SFG++ Sbjct: 195 GVDGKKIYKLTDFGLAR-GTPDQTMVQS--VVGTRHYYAPEVVENGFYNSTVDLWSFGVI 251 Query: 324 VLEIVSG 344 E+V+G Sbjct: 252 AYELVTG 258
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 62.8 bits (151), Expect = 7e-10 Identities = 35/92 (38%), Positives = 58/92 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ ++ E + IHRD++A+N+L+ + L+ KI+DFG+ARL +ED + Sbjct: 347 IAEGMAFIEERN---YIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFP 402 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE G + K+DV+SFG+L+ EIV+ Sbjct: 403 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVT 434
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 62.8 bits (151), Expect = 7e-10 Identities = 35/92 (38%), Positives = 58/92 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ ++ E + IHRD++A+N+L+ + L+ KI+DFG+ARL +ED + Sbjct: 347 IAEGMAFIEERN---YIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFP 402 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE G + K+DV+SFG+L+ EIV+ Sbjct: 403 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVT 434
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 61/99 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + RGL YL E+ +I+HRD+K SN+L++ + K+ DFG++ ++ N+F Sbjct: 172 KVSIAVLRGLAYLREKH--QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSF 227 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 228 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGR 264
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 168 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 223 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 224 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 167 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 222 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 223 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 167 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 222 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 223 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 167 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 222 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 223 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 167 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 222 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 223 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 61/99 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + RGL YL E+ +I+HRD+K SN+L++ + K+ DFG++ ++ N+F Sbjct: 172 KVSIAVLRGLAYLREKH--QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSF 227 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 228 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGR 264
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 161 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 216 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 217 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGR 253
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 62.8 bits (151), Expect = 7e-10 Identities = 33/99 (33%), Positives = 62/99 (62%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + +GL YL E+ KI+HRD+K SN+L++ + K+ DFG++ ++ + N+F Sbjct: 167 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSF 222 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 223 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGR 259
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 62.4 bits (150), Expect = 9e-10 Identities = 44/112 (39%), Positives = 66/112 (58%), Gaps = 8/112 (7%) Frame = +3 Query: 39 PKRHQIILGLAR----GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 P Q++ ++R GL YLH + IIHRD+KA N+L+D KISDFG+++ Sbjct: 926 PFEEQLVRFVSRQVLYGLSYLHSKG---IIHRDLKADNLLIDFDGVCKISDFGISK--HS 980 Query: 207 DATHVNTFRIS--GTYGYMAPEYAMNGY--LSTKTDVFSFGMLVLEIVSGRK 350 D + N +S G+ +MAPE N + S K DV+S G +VLE+++GR+ Sbjct: 981 DNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRR 1032
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 62.4 bits (150), Expect = 9e-10 Identities = 35/92 (38%), Positives = 58/92 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ Y+ + IHRD++++N+L+ L KI+DFG+ARL +ED + Sbjct: 373 VARGMAYIER---MNYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFP 428 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELVT 460
>STE7_CANAL (P46599) Serine/threonine-protein kinase STE7 homolog (EC 2.7.12.2)| Length = 589 Score = 62.4 bits (150), Expect = 9e-10 Identities = 37/98 (37%), Positives = 55/98 (56%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + GL YL+ KIIHRDIK +NVL+ K K+ DFG++R +TF Sbjct: 352 KLSFAILSGLTYLYTTH--KIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTF 409 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 GT YM+PE K+DV+S G++++E+ SG Sbjct: 410 --VGTSMYMSPERIQGLDYGVKSDVWSTGLMLIELASG 445
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/92 (38%), Positives = 58/92 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + IHRD++A+N+L+ E L KI+DFG+ARL +ED + Sbjct: 354 VAEGMAYMER---MNYIHRDLRAANILVGEYLICKIADFGLARL-IEDNEYNPQQGTKFP 409 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+++ Sbjct: 410 IKWTAPEAALFGRFTVKSDVWSFGILLTELIT 441
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/93 (38%), Positives = 55/93 (59%), Gaps = 2/93 (2%) Frame = +3 Query: 72 RGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRIS--GT 245 +GL +LH + +IHRDIK+ N+LL+ N KI+DFG F +N+ RI+ GT Sbjct: 1059 KGLKFLHSKG---VIHRDIKSDNILLNMDGNIKITDFG----FCAQINEINSKRITMVGT 1111 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 +MAPE K DV+S G++++E++ G Sbjct: 1112 PYWMAPEIVSRKEYGPKVDVWSLGIMIIEMLEG 1144
>NEK2_HUMAN (P51955) Serine/threonine-protein kinase Nek2 (EC 2.7.11.1)| (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) Length = 445 Score = 62.0 bits (149), Expect = 1e-09 Identities = 31/75 (41%), Positives = 46/75 (61%) Frame = +3 Query: 111 IIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS 290 ++HRD+K +NV LD K N K+ DFG+AR+ D + TF GT YM+PE + Sbjct: 137 VLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF--VGTPYYMSPEQMNRMSYN 194 Query: 291 TKTDVFSFGMLVLEI 335 K+D++S G L+ E+ Sbjct: 195 EKSDIWSLGCLLYEL 209
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 5/112 (4%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L WP + +II + + +LH P ++H D+K N+LLD ++ KISDFG+++ ++E Sbjct: 127 LCWPLKLRIIHETSLAMNFLHSIKP-PLLHLDLKPGNILLDNNMHVKISDFGLSK-WMEQ 184 Query: 210 AT---HVNTFRISGTYGYMAPEYAM--NGYLSTKTDVFSFGMLVLEIVSGRK 350 +T ++ + GT Y+ PE + N + DV+SF +++ EI++ +K Sbjct: 185 STQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKK 236
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 62.0 bits (149), Expect = 1e-09 Identities = 38/120 (31%), Positives = 62/120 (51%), Gaps = 12/120 (10%) Frame = +3 Query: 36 WPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 W +R +A G+ YLH + IIHRD+ + N L+ E + ++DFG+ARL +++ Sbjct: 441 WSQRVSFAKDIAAGMAYLHS---MNIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKN 497 Query: 216 ---HVNT---------FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 H+ + + G +MAPE K D+FSFG+++ EI+ GR + D Sbjct: 498 QPEHLQNLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDIFSFGIVLCEII-GRVSAD 556
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 62.0 bits (149), Expect = 1e-09 Identities = 35/92 (38%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 + G+ +L E + IHRD++A+N+L+ + L+ KI+DFG+ARL +ED + Sbjct: 347 IVEGMAFLEERN---YIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFP 402 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE G + K+DV+SFG+L+ EIV+ Sbjct: 403 IKWTAPEAINYGTFTIKSDVWSFGILMTEIVT 434
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/108 (34%), Positives = 60/108 (55%), Gaps = 1/108 (0%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMA-RL 197 R QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDFG + +L Sbjct: 214 REQLSLGKCLKYSLDVVNGLLFLHSQS---ILHLDLKPANILISEQDVCKISDFGCSQKL 270 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + I GTY + APE + K D++SFG+ + ++ + Sbjct: 271 QVLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTT 318
>GPRK2_DROME (P32866) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 714 Score = 62.0 bits (149), Expect = 1e-09 Identities = 46/134 (34%), Positives = 71/134 (52%), Gaps = 12/134 (8%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL +LH++ I++RD K N+LLD+ + +ISD G+A E + R+ GT Sbjct: 419 VACGLQHLHKQG---IVYRDCKPENILLDDHGHVRISDLGLAVEIPEG--EMVRGRV-GT 472 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG------------RKNIDRHLGDEKVDL 389 GYMAPE N + D FSFG L+ E++ G R+ +DR + K D Sbjct: 473 VGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRV---KEDP 529 Query: 390 LNYTWKLSEEGRSL 431 Y+ K ++E +S+ Sbjct: 530 EKYSSKFNDEAKSM 543
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/116 (31%), Positives = 67/116 (57%), Gaps = 1/116 (0%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS-GRKNIDRHLGDEKVDLLNYTWKL 410 + APE A+ G + K+DV+SFG+L+ E+ + GR + E +D + +++ Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERAYRM 480
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/94 (38%), Positives = 55/94 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L GL YLH + I+HRDIK +N+L+D + K++DFG ++ E AT + GT Sbjct: 180 LLLGLEYLHNHA---IMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGT 236 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE + S D++S G V+E+V+G+ Sbjct: 237 PYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGK 270
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 62.0 bits (149), Expect = 1e-09 Identities = 33/99 (33%), Positives = 61/99 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 ++ + + RGL YL E+ +I+HRD+K SN+L++ + K+ DFG++ ++ N+F Sbjct: 170 KVSIAVLRGLAYLREKH--QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSF 225 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 GT YM+PE + S ++D++S G+ ++E+ GR Sbjct: 226 --VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGR 262
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/124 (33%), Positives = 65/124 (52%), Gaps = 5/124 (4%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL +LH+ II+RD+K NV+LD + + KI+DFGM + + D TF GT Y Sbjct: 449 GLFFLHKRG---IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF--CGTPDY 503 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLL-----NYTWKLSEE 419 +APE D +++G+L+ E+++G+ D DE + +Y LS+E Sbjct: 504 IAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKE 563 Query: 420 GRSL 431 S+ Sbjct: 564 AVSI 567
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/124 (33%), Positives = 65/124 (52%), Gaps = 5/124 (4%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL +LH+ II+RD+K NV+LD + + KI+DFGM + + D TF GT Y Sbjct: 449 GLFFLHKRG---IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF--CGTPDY 503 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLL-----NYTWKLSEE 419 +APE D +++G+L+ E+++G+ D DE + +Y LS+E Sbjct: 504 IAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKE 563 Query: 420 GRSL 431 S+ Sbjct: 564 AVSI 567
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/124 (33%), Positives = 65/124 (52%), Gaps = 5/124 (4%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL +LH+ II+RD+K NV+LD + + KI+DFGM + + D TF GT Y Sbjct: 449 GLFFLHKRG---IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF--CGTPDY 503 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLL-----NYTWKLSEE 419 +APE D +++G+L+ E+++G+ D DE + +Y LS+E Sbjct: 504 IAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKE 563 Query: 420 GRSL 431 S+ Sbjct: 564 AVSI 567
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/124 (33%), Positives = 65/124 (52%), Gaps = 5/124 (4%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL +LH+ II+RD+K NV+LD + + KI+DFGM + + D TF GT Y Sbjct: 449 GLFFLHKRG---IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF--CGTPDY 503 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLL-----NYTWKLSEE 419 +APE D +++G+L+ E+++G+ D DE + +Y LS+E Sbjct: 504 IAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKE 563 Query: 420 GRSL 431 S+ Sbjct: 564 AVSI 567
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/90 (40%), Positives = 57/90 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ YL E+ +++HRD+ A NVL+D+ L K++DFG+ARL L+D + + Sbjct: 334 VAEGMSYLEEQ---RVVHRDLAARNVLVDDGLACKVADFGLARL-LKDDIYSPSSSSKIP 389 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEI 335 + APE A S K+DV+SFG+L+ E+ Sbjct: 390 VKWTAPEAANYRVFSQKSDVWSFGVLLHEV 419
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 62.0 bits (149), Expect = 1e-09 Identities = 38/116 (32%), Positives = 65/116 (56%), Gaps = 4/116 (3%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF--- 200 L WP+R I GL + YLH ++IIH ++K+SNVLLD+ L PK++ MA L Sbjct: 307 LPWPQRVSICSGLLCAVEYLHG---LEIIHSNVKSSNVLLDQNLTPKLA-HPMAHLCPVN 362 Query: 201 -LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRH 365 T + T + + Y+ ++ G L+ + D+FS G+++ E+++G +D + Sbjct: 363 KRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 377 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 432 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 433 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 464
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/104 (35%), Positives = 60/104 (57%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLED 209 L P+ + +A G+ Y+ + IHRD++A+N+L+ E L KI+DFG+ARL +ED Sbjct: 363 LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLVCKIADFGLARL-IED 418 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + APE A+ G + K+DV+SFG+L E+ + Sbjct: 419 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELTT 462
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 368 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 423 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 424 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 455
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 368 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 423 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 424 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 455
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 61.6 bits (148), Expect = 2e-09 Identities = 34/89 (38%), Positives = 54/89 (60%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL YLH E +IHRDIKA+N+LL K++DFG++ + + + ++GT + Sbjct: 133 GLKYLHGEG---VIHRDIKAANILLSADNTVKLADFGVSTI-----VNSSALTLAGTLNW 184 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 MAPE N ST +D++S G V+E+++ Sbjct: 185 MAPEILGNRGASTLSDIWSLGATVVEMLT 213
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 61.6 bits (148), Expect = 2e-09 Identities = 34/101 (33%), Positives = 61/101 (60%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 P+ ++ +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 357 PQLVEMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEY 412 Query: 219 VNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 413 TARPGARFPVKWTAPEAALYGRFTIKSDVWSFGILLTELTT 453
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/114 (33%), Positives = 63/114 (55%), Gaps = 1/114 (0%) Frame = +3 Query: 6 STGXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFG 185 ++ +V+ +P ++ +A GLL+LH + I+HRD+ + N+LLDE N KISDFG Sbjct: 196 NSSTPKVKYSFPLVLKMATDMALGLLHLHS---ITIVHRDLTSQNILLDELGNIKISDFG 252 Query: 186 MARLFLEDATHVNTFRISGTYGYMAPEYAMN-GYLSTKTDVFSFGMLVLEIVSG 344 ++ + + T + PE N G+ S K DV+ F ++V EI++G Sbjct: 253 LSAEKSREGSMTMTNGGICNPRWRPPELTKNLGHYSEKVDVYCFSLVVWEILTG 306
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/106 (35%), Positives = 62/106 (58%), Gaps = 10/106 (9%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 I+ G+A G+ YL S + +HRD+ A N+L++ L K+SDFGM+R+ ED T R Sbjct: 100 ILRGIASGMKYL---SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTR 156 Query: 234 -ISGTY---------GYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 I+GTY + APE ++ +DV+S+G+++ E++S Sbjct: 157 EITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMS 202
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/102 (36%), Positives = 56/102 (54%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 P+ I+ +GL +LH++ IIHRDIK+ NVLLD + KI+DFG + + Sbjct: 668 PQIAYIVRETCQGLKFLHDKH---IIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSK 724 Query: 219 VNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 T + GT +MAPE K DV+S G++ +E++ G Sbjct: 725 RAT--MVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEG 764
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 61.6 bits (148), Expect = 2e-09 Identities = 29/78 (37%), Positives = 52/78 (66%) Frame = +3 Query: 111 IIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS 290 IIHRD+K N+L+ E+ K++DFG+A+ ++ +T +T + G+ Y +PE A Y Sbjct: 129 IIHRDVKPQNILVTEEGVVKVTDFGIAKS-MDSSTIAHTNSVMGSAHYFSPEQAKGTYTD 187 Query: 291 TKTDVFSFGMLVLEIVSG 344 +TD++S G+++ E+V+G Sbjct: 188 YRTDLYSLGIVLYEMVTG 205
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 61.6 bits (148), Expect = 2e-09 Identities = 40/136 (29%), Positives = 71/136 (52%), Gaps = 1/136 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDA-THVNT 227 ++ +G+ + L Y H I+HRDIK +NV+L K+ DFG+AR + T T Sbjct: 117 EMTIGILQALEYSHRAG---IVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQT 173 Query: 228 FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 + GT Y++PE A + ++D++S G L+ E+++ R +GD V + Sbjct: 174 AAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPF---VGDSPVAVAYQ--H 228 Query: 408 LSEEGRSLEIVDPGLS 455 + EE ++ + DP ++ Sbjct: 229 VREEPQAPSVFDPEIT 244
>KPCG_RABIT (P10829) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (PKC-delta) Length = 697 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/108 (36%), Positives = 62/108 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL +LH + II+RD+K NV+LD + + KI+DFGM + + T TF GT Sbjct: 464 IAIGLFFLHNQG---IIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTF--CGT 518 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 Y+APE D +SFG+L+ E+++G+ D G+++ +L Sbjct: 519 PDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD---GEDEEEL 563
>KPCG_HUMAN (P05129) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/108 (36%), Positives = 62/108 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL +LH + II+RD+K NV+LD + + KI+DFGM + + T TF GT Sbjct: 464 IAIGLFFLHNQG---IIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTF--CGT 518 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 Y+APE D +SFG+L+ E+++G+ D G+++ +L Sbjct: 519 PDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD---GEDEEEL 563
>ARBK1_RAT (P26817) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV- 351 Query: 231 RISGTYGYMAPEYAMNGY-LSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 MAVE 412
>ARBK1_MOUSE (Q99MK8) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKRPHASV- 351 Query: 231 RISGTYGYMAPEYAMNGY-LSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 MAVE 412
>ARBK1_MESAU (Q64682) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV- 351 Query: 231 RISGTYGYMAPEYAMNGY-LSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 MAVE 412
>ARBK1_HUMAN (P25098) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein coupled receptor kinase 2) Length = 689 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV- 351 Query: 231 RISGTYGYMAPEYAMNGY-LSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 MAVE 412
>ARBK1_BOVIN (P21146) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV- 351 Query: 231 RISGTYGYMAPEYAMNGY-LSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 MAVE 412
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 61.6 bits (148), Expect = 2e-09 Identities = 34/92 (36%), Positives = 58/92 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + IHRD++++N+L+ + L KI+DFG+ARL +ED + Sbjct: 373 VAAGMAYIER---MNYIHRDLRSANILVGDNLVCKIADFGLARL-IEDNEYTARQGAKFP 428 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELVT 460
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/112 (33%), Positives = 65/112 (58%), Gaps = 8/112 (7%) Frame = +3 Query: 30 LDWPKRHQIILG--------LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFG 185 LD P + +G +++G+ YL E +K++HRD+ A N+L+ E KISDFG Sbjct: 838 LDHPDERALTMGDLISFAWQISQGMQYLAE---MKLVHRDLAARNILVAEGRKMKISDFG 894 Query: 186 MARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 ++R E+ ++V + +MA E + +T++DV+SFG+L+ EIV+ Sbjct: 895 LSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 946
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/109 (34%), Positives = 61/109 (55%), Gaps = 2/109 (1%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDFG ++ Sbjct: 198 REQLSLGKCLKYSLDVVNGLLFLHSQS---ILHLDLKPANILISEQDVCKISDFGCSQK- 253 Query: 201 LED--ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 L+D + I GTY + APE + K D++SFG+ + ++ + Sbjct: 254 LQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTT 302
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/94 (40%), Positives = 53/94 (56%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L L YLH +I+HRD+K NVLLD+ ++ K+ DFG+AR + THV T I GT Sbjct: 109 LVSALYYLHSN---RILHRDLKPQNVLLDKNMHAKLCDFGLAR-NMTLGTHVLT-SIKGT 163 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 YMAPE D++S G + E ++G+ Sbjct: 164 PLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQ 197
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 369 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 424 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 425 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 456
>PKH1_YEAST (Q03407) Serine/threonine-protein kinase PKH1 (EC 2.7.11.1)| (3-phosphoinositide-dependent protein kinase 1) Length = 766 Score = 61.6 bits (148), Expect = 2e-09 Identities = 32/114 (28%), Positives = 64/114 (56%), Gaps = 14/114 (12%) Frame = +3 Query: 105 VKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT-----------HVNTFRISGTYG 251 + IIHRDIK N+LLD+ + K++DFG A++ E+ + + + GT Sbjct: 243 IGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAE 302 Query: 252 YMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR---KNIDRHLGDEKVDLLNYTW 404 Y++PE + Y ++ D+++FG ++ ++++G+ K + +L +KV + Y + Sbjct: 303 YVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYAF 356
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/109 (34%), Positives = 61/109 (55%), Gaps = 2/109 (1%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDFG ++ Sbjct: 198 REQLSLGKCLKYSLDVVNGLLFLHSQS---ILHLDLKPANILISEQDVCKISDFGCSQK- 253 Query: 201 LED--ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 L+D + I GTY + APE + K D++SFG+ + ++ + Sbjct: 254 LQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTT 302
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 61.6 bits (148), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 372 IASGMAYVER---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 427 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 428 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 459
>PKD1_DICDI (P34100) Developmentally-regulated protein kinase 1 (EC 2.7.11.1)| (Fragment) Length = 416 Score = 61.2 bits (147), Expect = 2e-09 Identities = 36/100 (36%), Positives = 61/100 (61%), Gaps = 2/100 (2%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 I+ + + YLH E+ II+RD+K N+L+DEK + K++DFG ++ + NT Sbjct: 139 IVAEIVLAIEYLHAEN---IIYRDLKPENILIDEKGHIKLTDFGFSK---KTVGGKNTSS 192 Query: 234 ISGTYGYMAPEY--AMNGYLSTKTDVFSFGMLVLEIVSGR 347 + GT+ YMAPE + NG+ D ++ G++V E+V+G+ Sbjct: 193 VCGTFDYMAPEILNSSNGH-GKPVDWWALGVVVYELVTGK 231
>KIC1_YEAST (P38692) Serine/threonine-protein kinase KIC1 (EC 2.7.11.1) (Kinase| that interacts with CDC31) (N-rich kinase 1) Length = 1080 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/98 (38%), Positives = 58/98 (59%), Gaps = 1/98 (1%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 I+ L L +H+++ +IHRDIKA+NVL+ + N K+ DFG+A + T + Sbjct: 124 IMRELLVALKCIHKDN---VIHRDIKAANVLITNEGNVKLCDFGVAAQV--NQTSLRRQT 178 Query: 234 ISGTYGYMAPEYAMNG-YLSTKTDVFSFGMLVLEIVSG 344 ++GT +MAPE M G Y TK D++S G+ EI +G Sbjct: 179 MAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATG 216
>VGFR1_MOUSE (P35969) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) Length = 1333 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/92 (41%), Positives = 54/92 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ +L S K IHRD+ A N+LL E KI DFG+AR ++ +V Sbjct: 1006 VARGMEFL---SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLP 1062 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 +MAPE + STK+DV+S+G+L+ EI S Sbjct: 1063 LKWMAPESIFDKVYSTKSDVWSYGVLLWEIFS 1094
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 4/97 (4%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH +S IIHRD+K++N+ L E L KI DFG+A + + ++SG+ Sbjct: 171 AQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 227 Query: 249 GYMAPEYA----MNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE N Y S ++DV++FG+++ E+++G+ Sbjct: 228 LWMAPEVIRMQDKNPY-SFQSDVYAFGIVLYELMTGQ 263
>ARBK2_BOVIN (P26818) Beta-adrenergic receptor kinase 2 (EC 2.7.11.15)| (Beta-ARK-2) (G-protein-coupled receptor kinase 3) Length = 688 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV- 351 Query: 231 RISGTYGYMAPEYAMNG-YLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 MNVE 412
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 4/97 (4%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH +S IIHRD+K++N+ L E L KI DFG+A + + ++SG+ Sbjct: 601 AQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 657 Query: 249 GYMAPEYA----MNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE N Y S ++DV++FG+++ E+++G+ Sbjct: 658 LWMAPEVIRMQDKNPY-SFQSDVYAFGIVLYELMTGQ 693
>VGFR1_RAT (P53767) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) Length = 1336 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/92 (41%), Positives = 54/92 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ +L S K IHRD+ A N+LL E KI DFG+AR ++ +V Sbjct: 1006 VARGMEFL---SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLP 1062 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 +MAPE + STK+DV+S+G+L+ EI S Sbjct: 1063 LKWMAPESIFDKVYSTKSDVWSYGVLLWEIFS 1094
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 61.2 bits (147), Expect = 2e-09 Identities = 34/95 (35%), Positives = 60/95 (63%), Gaps = 3/95 (3%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH ++ IIHRD+K++N+ L E L KI DFG+A + + +++G+ Sbjct: 444 AQGMDYLHAKN---IIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSI 500 Query: 249 GYMAPEYAM---NGYLSTKTDVFSFGMLVLEIVSG 344 +MAPE N S ++DV+S+G+++ E+++G Sbjct: 501 LWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTG 535
>VGFR1_HUMAN (P17948) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) Length = 1338 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/92 (41%), Positives = 54/92 (58%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ +L S K IHRD+ A N+LL E KI DFG+AR ++ +V Sbjct: 1006 VARGMEFL---SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 +MAPE + STK+DV+S+G+L+ EI S Sbjct: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 4/97 (4%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH +S IIHRD+K++N+ L E L KI DFG+A + + ++SG+ Sbjct: 601 AQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 657 Query: 249 GYMAPEYA----MNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE N Y S ++DV++FG+++ E+++G+ Sbjct: 658 LWMAPEVIRMQDKNPY-SFQSDVYAFGIVLYELMTGQ 693
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 61.2 bits (147), Expect = 2e-09 Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 2/104 (1%) Frame = +3 Query: 39 PKRH-QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 PKR ++I + L + H+ IIHRD+K +N+++ K+ DFG+AR + Sbjct: 112 PKRAIEVIADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSGN 168 Query: 216 HV-NTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 V T + GT Y++PE A + ++DV+S G ++ E+++G Sbjct: 169 SVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTG 212
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 61.2 bits (147), Expect = 2e-09 Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 2/104 (1%) Frame = +3 Query: 39 PKRH-QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDAT 215 PKR ++I + L + H+ IIHRD+K +N+++ K+ DFG+AR + Sbjct: 112 PKRAIEVIADACQALNFSHQNG---IIHRDVKPANIMISATNAVKVMDFGIARAIADSGN 168 Query: 216 HV-NTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 V T + GT Y++PE A + ++DV+S G ++ E+++G Sbjct: 169 SVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTG 212
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 4/97 (4%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH +S IIHRD+K++N+ L E L KI DFG+A + + ++SG+ Sbjct: 187 AQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 243 Query: 249 GYMAPEYA----MNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE N Y S ++DV++FG+++ E+++G+ Sbjct: 244 LWMAPEVIRMQDKNPY-SFQSDVYAFGIVLYELMTGQ 279
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 61.2 bits (147), Expect = 2e-09 Identities = 35/103 (33%), Positives = 59/103 (57%), Gaps = 1/103 (0%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 P+ + L G++YLH + I HRD+K N+LLDE+ N KISDFG+A +F + Sbjct: 105 PEAQRFFQQLIAGVVYLHS---MGITHRDLKPENLLLDERDNLKISDFGLATVFKHNGRE 161 Query: 219 VNTFRISGTYGYMAPEYAMN-GYLSTKTDVFSFGMLVLEIVSG 344 ++ GT Y+APE + + DV++ G+++ +++G Sbjct: 162 RLLNKMCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAG 204
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 4/97 (4%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH +S IIHRD+K++N+ L E L KI DFG+A + + ++SG+ Sbjct: 561 AQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 617 Query: 249 GYMAPEYA----MNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE N Y S ++DV++FG+++ E+++G+ Sbjct: 618 LWMAPEVIRMQDKNPY-SFQSDVYAFGIVLYELMTGQ 653
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 61.2 bits (147), Expect = 2e-09 Identities = 33/92 (35%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + +HRD++A+N+L+ E L K++DFG+ARL +ED + Sbjct: 372 IASGMAYVDR---MNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFP 427 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+ + Sbjct: 428 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT 459
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/97 (38%), Positives = 62/97 (63%), Gaps = 4/97 (4%) Frame = +3 Query: 69 ARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTY 248 A+G+ YLH +S IIHRD+K++N+ L E L KI DFG+A + + ++SG+ Sbjct: 123 AQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 179 Query: 249 GYMAPEYA----MNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE N Y S ++DV++FG+++ E+++G+ Sbjct: 180 LWMAPEVIRMQDKNPY-SFQSDVYAFGIVLYELMTGQ 215
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 60.8 bits (146), Expect = 3e-09 Identities = 37/108 (34%), Positives = 60/108 (55%), Gaps = 1/108 (0%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMA-RL 197 R QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDFG + +L Sbjct: 178 RKQLSLGKCLKYSLDVVNGLLFLHSQS---ILHLDLKPANILISEQDVCKISDFGCSQKL 234 Query: 198 FLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + I GTY + APE + K D++SFG+ + ++ + Sbjct: 235 QVLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTT 282
>VGFR3_HUMAN (P35916) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1298 Score = 60.8 bits (146), Expect = 3e-09 Identities = 37/92 (40%), Positives = 53/92 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ +L K IHRD+ A N+LL E KI DFG+AR +D +V Sbjct: 1021 VARGMEFLASR---KCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLP 1077 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 +MAPE + +T++DV+SFG+L+ EI S Sbjct: 1078 LKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS 1109
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 60.8 bits (146), Expect = 3e-09 Identities = 34/92 (36%), Positives = 58/92 (63%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ ++ + IHRD++A+N+L+ + L KI+DFG+ARL +ED + Sbjct: 380 IADGMAFIER---MNYIHRDLRAANILVADNLVCKIADFGLARL-IEDNEYTARQGAKFP 435 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 436 IKWTAPEAALYGRFTIKSDVWSFGILLTELVT 467
>VGFR3_RAT (Q91ZT1) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 60.8 bits (146), Expect = 3e-09 Identities = 37/92 (40%), Positives = 53/92 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ +L K IHRD+ A N+LL E KI DFG+AR +D +V Sbjct: 1021 VARGMEFLASR---KCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLP 1077 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 +MAPE + +T++DV+SFG+L+ EI S Sbjct: 1078 LKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS 1109
>VGFR3_MOUSE (P35917) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 60.8 bits (146), Expect = 3e-09 Identities = 37/92 (40%), Positives = 53/92 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +ARG+ +L K IHRD+ A N+LL E KI DFG+AR +D +V Sbjct: 1021 VARGMEFLASR---KCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLP 1077 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 +MAPE + +T++DV+SFG+L+ EI S Sbjct: 1078 LKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS 1109
>RIPK5_CHICK (Q6XUX0) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 60.8 bits (146), Expect = 3e-09 Identities = 43/112 (38%), Positives = 58/112 (51%) Frame = +3 Query: 9 TGXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGM 188 TG K L+ R QI L + G+ YLH + ++HRDIK NVLLD+K KI+D G Sbjct: 744 TGLK-AGLELETRLQIALDVVEGIRYLHSQG---LVHRDIKLKNVLLDKKNRAKITDLGF 799 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 + + + I GT +MAPE G DV++FG+L I SG Sbjct: 800 CK-----PEAMMSGSIVGTPIHMAPE-LFTGKYDNSVDVYAFGILFWYICSG 845
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 60.8 bits (146), Expect = 3e-09 Identities = 31/75 (41%), Positives = 47/75 (62%) Frame = +3 Query: 111 IIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS 290 ++HRDIK +N+ LDE + K+ DFG+++L D T V T GT YM+PE + S Sbjct: 147 VLHRDIKPANIFLDENNSVKLGDFGLSKLL--DNTRVFTQSYVGTPYYMSPEIIRSSPYS 204 Query: 291 TKTDVFSFGMLVLEI 335 K+DV++ G ++ EI Sbjct: 205 AKSDVWALGCVIFEI 219
>ARBK2_HUMAN (P35626) Beta-adrenergic receptor kinase 2 (EC 2.7.11.15)| (Beta-ARK-2) (G-protein-coupled receptor kinase 3) Length = 688 Score = 60.8 bits (146), Expect = 3e-09 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 1/124 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +IILGL ++H +++RD+K +N+LLDE + +ISD G+A F + H + Sbjct: 300 EIILGLE----HVHNRF---VVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV- 351 Query: 231 RISGTYGYMAPEYAMNG-YLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTWK 407 GT+GYMAPE G + D FS G ++ +++ G +H +K ++ T Sbjct: 352 ---GTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 408 LSEE 419 ++ E Sbjct: 409 VNVE 412
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/117 (35%), Positives = 61/117 (52%), Gaps = 13/117 (11%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP-------VKIIHRDIKASNVLLDEKLNPKISDFGM 188 + W + I +ARGL YLHE+ P I HRDIK+ NVLL L I+DFG+ Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGL 343 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS------TKTDVFSFGMLVLEIVS 341 A F + +T GT YMAPE + G ++ + D+++ G+++ E+ S Sbjct: 344 ALKFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_RAT (P38444) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/117 (35%), Positives = 61/117 (52%), Gaps = 13/117 (11%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP-------VKIIHRDIKASNVLLDEKLNPKISDFGM 188 + W + I +ARGL YLHE+ P I HRDIK+ NVLL L I+DFG+ Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGL 343 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS------TKTDVFSFGMLVLEIVS 341 A F + +T GT YMAPE + G ++ + D+++ G+++ E+ S Sbjct: 344 ALKFEAGKSGGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/117 (35%), Positives = 61/117 (52%), Gaps = 13/117 (11%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP-------VKIIHRDIKASNVLLDEKLNPKISDFGM 188 + W + I +ARGL YLHE+ P I HRDIK+ NVLL L I+DFG+ Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGL 343 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS------TKTDVFSFGMLVLEIVS 341 A F + +T GT YMAPE + G ++ + D+++ G+++ E+ S Sbjct: 344 ALKFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/117 (35%), Positives = 61/117 (52%), Gaps = 13/117 (11%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP-------VKIIHRDIKASNVLLDEKLNPKISDFGM 188 + W + I +ARGL YLHE+ P I HRDIK+ NVLL L I+DFG+ Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGL 343 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS------TKTDVFSFGMLVLEIVS 341 A F + +T GT YMAPE + G ++ + D+++ G+++ E+ S Sbjct: 344 ALKFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/117 (35%), Positives = 61/117 (52%), Gaps = 13/117 (11%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP-------VKIIHRDIKASNVLLDEKLNPKISDFGM 188 + W + I +ARGL YLHE+ P I HRDIK+ NVLL L I+DFG+ Sbjct: 284 VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGL 343 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS------TKTDVFSFGMLVLEIVS 341 A F + +T GT YMAPE + G ++ + D+++ G+++ E+ S Sbjct: 344 ALKFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 60.8 bits (146), Expect = 3e-09 Identities = 35/94 (37%), Positives = 54/94 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L GL YLH I+HRDIK +N+L+D K +++DFG ++ +E AT + GT Sbjct: 180 LLLGLEYLHNNG---IMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGT 236 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +MAPE + S D++S G V+E+ +G+ Sbjct: 237 PYWMAPEVILQTGHSFSADIWSVGCTVIEMATGK 270
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 60.5 bits (145), Expect = 4e-09 Identities = 40/120 (33%), Positives = 65/120 (54%), Gaps = 3/120 (2%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR--IS 239 +A G+ YL + IHRD+ A NVL+ E K++DFG+AR+F D + R I Sbjct: 338 VASGMAYLESRN---YIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394 Query: 240 GTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS-GRKNIDRHLGDEKVDLLNYTWKLSE 416 + APE + S K+DV+SFG+L+ EI++ G+ G + + +L ++L + Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ 454
>SPKA_SYNY3 (Q9FAB3) Serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 521 Score = 60.5 bits (145), Expect = 4e-09 Identities = 41/105 (39%), Positives = 61/105 (58%), Gaps = 7/105 (6%) Frame = +3 Query: 51 QIILGLA---RGLLYLHEESPVKIIHRDIKASNVLL--DEKLNP--KISDFGMARLFLED 209 QI GL +G++Y E PV +HRDIK SNVLL D L KI DFG+A+L ++ Sbjct: 123 QICFGLDCAHKGIIYQGEACPV--VHRDIKPSNVLLVEDPALGELVKILDFGIAKL-VQA 179 Query: 210 ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 A T GT Y +PE L +++D++S G+++ E+++G Sbjct: 180 AEESKTQAFMGTLAYCSPEQMEGKELDSRSDIYSLGVMMYEMLTG 224
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 60.5 bits (145), Expect = 4e-09 Identities = 35/90 (38%), Positives = 55/90 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ YL E +++HRD+ A NVL+ + L K++DFG+ARL L+D + + Sbjct: 338 VAEGMSYLEER---RVVHRDLAARNVLVGDDLTCKVADFGLARL-LKDDVYSPSSGSKIP 393 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEI 335 + APE A S K+DV+SFG+L+ E+ Sbjct: 394 VKWTAPEAANYRVFSQKSDVWSFGILLYEV 423
>RIPK5_XENLA (Q67E01) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 916 Score = 60.5 bits (145), Expect = 4e-09 Identities = 55/172 (31%), Positives = 79/172 (45%) Frame = +3 Query: 45 RHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVN 224 R QI L + G+ +LH + ++HRDIK NVLLD+K KI+D G + + Sbjct: 743 RLQIALDVVEGIRFLHNQG---VVHRDIKLKNVLLDKKHRAKITDLGFCK-----PEAMM 794 Query: 225 TFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTW 404 + I GT +MAPE +G DV++FG+L I SG + EK ++ W Sbjct: 795 SGSIVGTPIHMAPE-LFSGKYDNSVDVYAFGILFWYICSGSVKLPEAF--EKCASKDHLW 851 Query: 405 KLSEEGRSLEIVDPGLSGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLML 560 +G E L+ +D C +L C S+RP M V ML Sbjct: 852 NNVRKGARPE----RLTIFDE----ECWKLMEACWNGDPSQRPLMGIVQPML 895
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 60.5 bits (145), Expect = 4e-09 Identities = 42/130 (32%), Positives = 70/130 (53%), Gaps = 8/130 (6%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL YLH + I++RD+K NV+LD + + KI+DFGM + + TF GT Sbjct: 428 IAIGLFYLHTQG---IVYRDLKLDNVMLDAEGHIKIADFGMCKENIMGDKTTRTF--CGT 482 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL--------LNYT 401 Y+APE + D +++G+L+ E+++G+ D G+++ +L ++Y Sbjct: 483 PDYIAPEIVLYQPYGRSVDWWAYGVLLYEMLAGQPPFD---GEDEEELFTSITDHNVSYP 539 Query: 402 WKLSEEGRSL 431 LS E SL Sbjct: 540 KALSREAVSL 549
>KPCA_MOUSE (P20444) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 60.5 bits (145), Expect = 4e-09 Identities = 40/124 (32%), Positives = 66/124 (53%), Gaps = 5/124 (4%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL +LH+ II+RD+K +NV+L+ + + KI+DFGM + + D TF GT Y Sbjct: 449 GLFFLHKRG---IIYRDLKLNNVMLNSEGHIKIADFGMCKEHMMDGVTTRTF--CGTPDY 503 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLL-----NYTWKLSEE 419 +APE D +++G+L+ E+++G+ D DE + +Y LS+E Sbjct: 504 IAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKE 563 Query: 420 GRSL 431 S+ Sbjct: 564 AVSI 567
>GRK2_CAEEL (Q09639) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 707 Score = 60.5 bits (145), Expect = 4e-09 Identities = 38/128 (29%), Positives = 66/128 (51%), Gaps = 5/128 (3%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL ++H +++RD+K +N+LLDE + ++SD G+A + + H + GT+GY Sbjct: 305 GLEHMHNRF---VVYRDLKPANILLDENGHVRVSDLGLACDYSKKKPHASV----GTHGY 357 Query: 255 MAPEYAMNGY-LSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL----LNYTWKLSEE 419 MAPE G + D FS G ++ +++ G +H +K ++ L +L E Sbjct: 358 MAPEVLAKGVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKDKNEIDKMTLTQDIELPNE 417 Query: 420 GRSLEIVD 443 G S + D Sbjct: 418 GLSKDCRD 425
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 60.5 bits (145), Expect = 4e-09 Identities = 35/105 (33%), Positives = 60/105 (57%) Frame = +3 Query: 27 QLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLE 206 +L P+ + +A G+ Y+ + IHRD++A+N+L+ E L KI+DFG+AR+ Sbjct: 330 RLSLPRLIDMSAQIAEGMAYIER---MNSIHRDLRAANILVSEALCCKIADFGLARII-- 384 Query: 207 DATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 D+ + + APE G + K DV+SFG+L++E+V+ Sbjct: 385 DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVT 429
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 60.5 bits (145), Expect = 4e-09 Identities = 35/92 (38%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ ++ ++ IHRD++A+N+L+ E L KI+DFG+ARL +ED + Sbjct: 346 IAEGMAFIEAKN---YIHRDLRAANILVSEALCCKIADFGLARL-IEDNEYTAREGAKFP 401 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE G + K+DV+SFG+L+ EIV+ Sbjct: 402 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVT 433
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 60.5 bits (145), Expect = 4e-09 Identities = 36/91 (39%), Positives = 51/91 (56%) Frame = +3 Query: 72 RGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYG 251 +GL +LH++ IIHRDIK+ NVLLD N KI+DFG + T + GT Sbjct: 789 KGLQHLHKKH---IIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNKRAT--MVGTPY 843 Query: 252 YMAPEYAMNGYLSTKTDVFSFGMLVLEIVSG 344 +MAPE K DV+S G++ +E++ G Sbjct: 844 WMAPEVVKQKEYDEKVDVWSLGIMTIEMIEG 874
>MOS_HUMAN (P00540) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 60.5 bits (145), Expect = 4e-09 Identities = 40/115 (34%), Positives = 63/115 (54%), Gaps = 2/115 (1%) Frame = +3 Query: 3 CSTGXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDF 182 C TG QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDF Sbjct: 167 CRTGG---QLSLGKCLKYSLDVVNGLLFLHSQS---IVHLDLKPANILISEQDVCKISDF 220 Query: 183 GMARLFLEDATHVNT--FRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 G + LED T + + GTY + APE ++ K D++SF + + ++ + Sbjct: 221 GCSEK-LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTT 274
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 60.5 bits (145), Expect = 4e-09 Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 5/109 (4%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLL---DEKLNPKISDFGMARLF 200 L WP R + L +ARGL YLH + + HRD+ + N L+ D + DFG+A Sbjct: 147 LSWPVRLHLALDIARGLRYLHSKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI 203 Query: 201 --LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + + G+ +MAPE K DVF+FG+++ E+++ Sbjct: 204 PVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 252
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 60.5 bits (145), Expect = 4e-09 Identities = 36/99 (36%), Positives = 54/99 (54%) Frame = +3 Query: 54 IILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFR 233 + L L L Y+H K++HRDIK++NVLL K+ DFG + + + + V Sbjct: 127 LFLQLCLALDYIHSH---KMLHRDIKSANVLLTSTGLVKLGDFGFSHQYEDTVSGVVAST 183 Query: 234 ISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRK 350 GT Y+APE N + K DV+S G+L+ EI+ +K Sbjct: 184 FCGTPYYLAPELWNNKRYNKKADVWSLGVLLYEIMGMKK 222
>MOS_PIG (P50118) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 345 Score = 60.5 bits (145), Expect = 4e-09 Identities = 38/113 (33%), Positives = 61/113 (53%) Frame = +3 Query: 3 CSTGXKRVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDF 182 CS G QL+ K + L + GLL+LH + I+H D+K +N+L+ E+ KISDF Sbjct: 168 CSAGE---QLNLEKCLKYSLDVVSGLLFLHSQG---IVHLDLKPANILISEQDVCKISDF 221 Query: 183 GMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 G + LED + GTY + APE ++ K D++SF + + ++ + Sbjct: 222 GCSER-LEDLRFRPRHHLGGTYTHRAPELLKGEPVTPKADIYSFAITLWQMTT 273
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 60.5 bits (145), Expect = 4e-09 Identities = 36/94 (38%), Positives = 56/94 (59%), Gaps = 1/94 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L G++YLH + I HRDIK N+LLDE+ N KISDFG+A +F + ++ GT Sbjct: 114 LMAGVVYLHG---IGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGT 170 Query: 246 YGYMAPE-YAMNGYLSTKTDVFSFGMLVLEIVSG 344 Y+APE + + DV+S G+++ +++G Sbjct: 171 LPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAG 204
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 60.5 bits (145), Expect = 4e-09 Identities = 36/94 (38%), Positives = 56/94 (59%), Gaps = 1/94 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L G++YLH + I HRDIK N+LLDE+ N KISDFG+A +F + ++ GT Sbjct: 114 LMAGVVYLHG---IGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGT 170 Query: 246 YGYMAPE-YAMNGYLSTKTDVFSFGMLVLEIVSG 344 Y+APE + + DV+S G+++ +++G Sbjct: 171 LPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAG 204
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 60.5 bits (145), Expect = 4e-09 Identities = 38/109 (34%), Positives = 61/109 (55%), Gaps = 2/109 (1%) Frame = +3 Query: 21 RVQLDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLF 200 R QL K + L + GLL+LH +S I+H D+K +N+L+ E+ KISDFG ++ Sbjct: 198 RKQLSLGKCLKYSLDVVNGLLFLHSQS---ILHLDLKPANILISEQDVCKISDFGCSQK- 253 Query: 201 LED--ATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 L+D + I GTY + APE + K D++SFG+ + ++ + Sbjct: 254 LQDLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTT 302
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 60.5 bits (145), Expect = 4e-09 Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 5/109 (4%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLL---DEKLNPKISDFGMARLF 200 L WP R + L +A+GL YLH + + HRD+ + N L+ D + DFG+A Sbjct: 142 LSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI 198 Query: 201 --LEDATHVNTFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + T + G+ +MAPE K DVF+FG+++ E+++ Sbjct: 199 PVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 247
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 60.5 bits (145), Expect = 4e-09 Identities = 40/118 (33%), Positives = 65/118 (55%), Gaps = 1/118 (0%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +I + ++ GL YL++ +IIHRD+K SN+L++ KI DFG++ + +TF Sbjct: 209 KIAVAVSHGLTYLYDVH--RIIHRDVKPSNILVNGAGQIKICDFGVSGELINSIA--DTF 264 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL-LNYT 401 GT YM+PE S K+DV+S G+ ++++ GR + D+ D NYT Sbjct: 265 --VGTSTYMSPERIQGDQYSVKSDVWSLGVSIIDVALGRFPFAENEEDDDSDADNNYT 320
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 60.1 bits (144), Expect = 5e-09 Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 2/113 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF-RISG 242 + RGL Y+H + ++HRD+K SN+LL+ + KI DFG+AR+ D H Sbjct: 132 ILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVA 188 Query: 243 TYGYMAPEYAMNGYLSTKT-DVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNY 398 T Y APE +N TK+ D++S G ++ E++S R G +D LN+ Sbjct: 189 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHYLDQLNH 238
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 60.1 bits (144), Expect = 5e-09 Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 2/113 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF-RISG 242 + RGL Y+H + ++HRD+K SN+LL+ + KI DFG+AR+ D H Sbjct: 132 ILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVA 188 Query: 243 TYGYMAPEYAMNGYLSTKT-DVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNY 398 T Y APE +N TK+ D++S G ++ E++S R G +D LN+ Sbjct: 189 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHYLDQLNH 238
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.1 bits (144), Expect = 5e-09 Identities = 31/98 (31%), Positives = 60/98 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A+ L + H+ I+HRDIK N+++ + K++DFG+A+ E +T T ++ G+ Sbjct: 117 IAKALNFAHKNG---IVHRDIKPHNIMVTDDDIIKVTDFGIAKASNE-STITTTNKVVGS 172 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 Y++PE A + +TD++SFG+++ E+ +G+ D Sbjct: 173 AHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVPYD 210
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 60.1 bits (144), Expect = 5e-09 Identities = 28/83 (33%), Positives = 53/83 (63%) Frame = +3 Query: 111 IIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS 290 ++HRDIK N+L++++ + +I+DFG+A+ AT +T + GT Y+APE N + Sbjct: 136 VVHRDIKPENILINDRGHVQITDFGLAKA-ASQATLSSTGMLLGTAAYLAPEMIENNQAT 194 Query: 291 TKTDVFSFGMLVLEIVSGRKNID 359 + D++S G++ E+++G+ D Sbjct: 195 AQGDLYSVGIMAWEMLTGKVPFD 217
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 60.1 bits (144), Expect = 5e-09 Identities = 28/78 (35%), Positives = 51/78 (65%) Frame = +3 Query: 111 IIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS 290 ++HRD+K N+L+ + + K++DFG+ R + A+ +T I GT Y++PE +G Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGLVRA-VAAASITSTGVILGTAAYLSPEQVRDGNAD 196 Query: 291 TKTDVFSFGMLVLEIVSG 344 ++DV+S G+LV E+++G Sbjct: 197 PRSDVYSVGVLVYELLTG 214
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 60.1 bits (144), Expect = 5e-09 Identities = 28/78 (35%), Positives = 51/78 (65%) Frame = +3 Query: 111 IIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS 290 ++HRD+K N+L+ + + K++DFG+ R + A+ +T I GT Y++PE +G Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGLVRA-VAAASITSTGVILGTAAYLSPEQVRDGNAD 196 Query: 291 TKTDVFSFGMLVLEIVSG 344 ++DV+S G+LV E+++G Sbjct: 197 PRSDVYSVGVLVYELLTG 214
>KPCG_BOVIN (P05128) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (Fragment) Length = 682 Score = 60.1 bits (144), Expect = 5e-09 Identities = 38/108 (35%), Positives = 62/108 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL +LH + II+RD+K NV+LD + + KI+DFGM + + + TF GT Sbjct: 449 IAIGLFFLHNQG---IIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTF--CGT 503 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 Y+APE D +SFG+L+ E+++G+ D G+++ +L Sbjct: 504 PDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD---GEDEEEL 548
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 60.1 bits (144), Expect = 5e-09 Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 2/113 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF-RISG 242 + RGL Y+H + ++HRD+K SN+LL+ + KI DFG+AR+ D H Sbjct: 136 ILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVA 192 Query: 243 TYGYMAPEYAMNGYLSTKT-DVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNY 398 T Y APE +N TK+ D++S G ++ E++S R G +D LN+ Sbjct: 193 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHYLDQLNH 242
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 60.1 bits (144), Expect = 5e-09 Identities = 35/97 (36%), Positives = 60/97 (61%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 Q L +A G+ YL + K++HRD+ A N+L+ E L K+SDFG+A+ + +++ Sbjct: 331 QFSLHVAEGMEYLESK---KLVHRDLAARNILVSEDLVAKVSDFGLAK---AERKGLDSS 384 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 R+ + APE +G ++K+DV+SFG+L+ E+ S Sbjct: 385 RL--PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS 419
>KPCT_MOUSE (Q02111) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 707 Score = 60.1 bits (144), Expect = 5e-09 Identities = 35/91 (38%), Positives = 53/91 (58%) Frame = +3 Query: 75 GLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGTYGY 254 GL +LH + I++RD+K N+LLD + KI+DFGM + + NTF GT Y Sbjct: 491 GLQFLHSKG---IVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTF--CGTPDY 545 Query: 255 MAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR 347 +APE + + D +SFG+LV E++ G+ Sbjct: 546 IAPEILLGQKYNHSVDWWSFGVLVYEMLIGQ 576
>KPCG_RAT (P63319) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 60.1 bits (144), Expect = 5e-09 Identities = 38/108 (35%), Positives = 62/108 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL +LH + II+RD+K NV+LD + + KI+DFGM + + + TF GT Sbjct: 464 IAIGLFFLHNQG---IIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTF--CGT 518 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 Y+APE D +SFG+L+ E+++G+ D G+++ +L Sbjct: 519 PDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD---GEDEEEL 563
>KPCG_MOUSE (P63318) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 60.1 bits (144), Expect = 5e-09 Identities = 38/108 (35%), Positives = 62/108 (57%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A GL +LH + II+RD+K NV+LD + + KI+DFGM + + + TF GT Sbjct: 464 IAIGLFFLHNQG---IIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTF--CGT 518 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDL 389 Y+APE D +SFG+L+ E+++G+ D G+++ +L Sbjct: 519 PDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD---GEDEEEL 563
>BYR1_SCHPO (P10506) Protein kinase byr1 (EC 2.7.12.2) (MAPK kinase) (MAPKK)| Length = 340 Score = 60.1 bits (144), Expect = 5e-09 Identities = 35/112 (31%), Positives = 62/112 (55%), Gaps = 5/112 (4%) Frame = +3 Query: 51 QIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF 230 +II + +GL+YL+ + + IIHRD+K SNV+++ + K+ DFG++ + Sbjct: 164 KIINSMVKGLIYLY--NVLHIIHRDLKPSNVVVNSRGEIKLCDFGVSGELVNSVAQT--- 218 Query: 231 RISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGR-----KNIDRHLG 371 GT YM+PE G + K+D++S G+ ++E+ + NID +G Sbjct: 219 -FVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQELPWSFSNIDDSIG 269
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 60.1 bits (144), Expect = 5e-09 Identities = 34/92 (36%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + IHRD++++N+L+ L KI+DFG+ARL +ED + Sbjct: 373 VAAGMAYIER---MNYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFP 428 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELVT 460
>AVR2B_PIG (Q66T47) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 60.1 bits (144), Expect = 5e-09 Identities = 41/125 (32%), Positives = 62/125 (49%), Gaps = 15/125 (12%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP--------VKIIHRDIKASNVLLDEKLNPKISDFG 185 + W + + ++RGL YLHE+ P I HRD K+ NVLL L ++DFG Sbjct: 282 ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFG 341 Query: 186 MARLFLEDATHVNTFRISGTYGYMAPE-------YAMNGYLSTKTDVFSFGMLVLEIVSG 344 +A F +T GT YMAPE + N +L + D+++ G+++ E+VS Sbjct: 342 LAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRNAFL--RIDMYAMGLVLWELVSR 399 Query: 345 RKNID 359 K D Sbjct: 400 CKAAD 404
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 60.1 bits (144), Expect = 5e-09 Identities = 41/115 (35%), Positives = 66/115 (57%), Gaps = 4/115 (3%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRIS-- 239 + RGL Y+H + ++HRD+K SN+LL++ + KI DFG+AR + D H +T ++ Sbjct: 146 ILRGLKYIHSAN---VLHRDLKPSNLLLNKTCDLKICDFGLAR--IADPEHDHTGFLTEY 200 Query: 240 -GTYGYMAPEYAMNGYLSTKT-DVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNY 398 T Y APE +N TK+ D++S G ++ E++S R G +D LN+ Sbjct: 201 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHYLDQLNH 252
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 60.1 bits (144), Expect = 5e-09 Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 2/113 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF-RISG 242 + RGL Y+H + ++HRD+K SN+LL+ + KI DFG+AR+ D H Sbjct: 130 ILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVA 186 Query: 243 TYGYMAPEYAMNGYLSTKT-DVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNY 398 T Y APE +N TK+ D++S G ++ E++S R G +D LN+ Sbjct: 187 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHYLDQLNH 236
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 60.1 bits (144), Expect = 5e-09 Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 2/113 (1%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTF-RISG 242 + RGL Y+H + ++HRD+K SN+LL+ + KI DFG+AR+ D H Sbjct: 130 ILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVA 186 Query: 243 TYGYMAPEYAMNGYLSTKT-DVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNY 398 T Y APE +N TK+ D++S G ++ E++S R G +D LN+ Sbjct: 187 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHYLDQLNH 236
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 60.1 bits (144), Expect = 5e-09 Identities = 34/92 (36%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + IHRD++++N+L+ L KI+DFG+ARL +ED + Sbjct: 370 VAAGMAYIER---MNYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFP 425 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 426 IKWTAPEAALYGRFTIKSDVWSFGILLTELVT 457
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 60.1 bits (144), Expect = 5e-09 Identities = 34/92 (36%), Positives = 57/92 (61%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 +A G+ Y+ + IHRD++++N+L+ L KI+DFG+ARL +ED + Sbjct: 370 VAAGMAYIER---MNYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFP 425 Query: 246 YGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVS 341 + APE A+ G + K+DV+SFG+L+ E+V+ Sbjct: 426 IKWTAPEAALYGRFTIKSDVWSFGILLTELVT 457
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 60.1 bits (144), Expect = 5e-09 Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 1/103 (0%) Frame = +3 Query: 39 PKRHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATH 218 P + L G++YLH + I HRDIK N+LLDE+ N KISDFG+A +F + Sbjct: 105 PDAQRFFHQLMAGVVYLHG---IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRE 161 Query: 219 VNTFRISGTYGYMAPE-YAMNGYLSTKTDVFSFGMLVLEIVSG 344 ++ GT Y+APE + + DV+S G+++ +++G Sbjct: 162 RLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAG 204
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 60.1 bits (144), Expect = 5e-09 Identities = 43/152 (28%), Positives = 73/152 (48%), Gaps = 29/152 (19%) Frame = +3 Query: 66 LARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVNTFRISGT 245 L LL+LH++ + HRDIK N+L+ + KISDFG+A++ T + TF GT Sbjct: 278 LLETLLHLHKQG---VTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETF--CGT 332 Query: 246 YGYMAPEYA------MNGYLSTKTDVFSFGMLV------------------LEIVSG--- 344 GY+APE ++G K D++S G ++ +E++S Sbjct: 333 MGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAY 392 Query: 345 --RKNIDRHLGDEKVDLLNYTWKLSEEGRSLE 434 ++ + +E +DL+N +++ E R E Sbjct: 393 PIEPLLENEISEEGIDLINRMLEINPEKRISE 424
>AVR2A_XENLA (P27039) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type II) (ACTR-II) Length = 514 Score = 60.1 bits (144), Expect = 5e-09 Identities = 40/117 (34%), Positives = 62/117 (52%), Gaps = 13/117 (11%) Frame = +3 Query: 30 LDWPKRHQIILGLARGLLYLHEESP-------VKIIHRDIKASNVLLDEKLNPKISDFGM 188 + W + I +ARGL +LHE+ P + HRDIK+ NVLL L I+DFG+ Sbjct: 285 VSWNELCLIAETMARGLSHLHEDIPGLKDGHKPAVAHRDIKSKNVLLKNNLTACIADFGL 344 Query: 189 ARLFLEDATHVNTFRISGTYGYMAPEYAMNGYLS------TKTDVFSFGMLVLEIVS 341 A F + +T GT YMAPE + G ++ + D+++FG+++ E+ S Sbjct: 345 ALKFEAGKSAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAFGLVLWELAS 400
>RIPK5_XENTR (Q67E00) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 918 Score = 60.1 bits (144), Expect = 5e-09 Identities = 55/172 (31%), Positives = 79/172 (45%) Frame = +3 Query: 45 RHQIILGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNPKISDFGMARLFLEDATHVN 224 R QI L + G+ +LH + ++HRDIK NVLLD+K KI+D G + + Sbjct: 745 RLQIALDVVEGIRFLHNQG---LVHRDIKLKNVLLDKKHRAKITDLGFCK-----PEAMM 796 Query: 225 TFRISGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNIDRHLGDEKVDLLNYTW 404 + I GT +MAPE +G DV++FG+L I SG + EK ++ W Sbjct: 797 SGSIVGTPIHMAPE-LFSGKYDNSVDVYAFGILFWYICSGSVKLPEAF--EKCASKDHLW 853 Query: 405 KLSEEGRSLEIVDPGLSGWDAGEVGMCVQLGLLCCQAVVSERPDMYSVHLML 560 +G E L+ +D C +L C S+RP M V ML Sbjct: 854 NNVRKGARPE----RLAIFDE----ECWKLMEACWNGDPSQRPLMGIVQPML 897
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 59.7 bits (143), Expect = 6e-09 Identities = 38/101 (37%), Positives = 56/101 (55%), Gaps = 1/101 (0%) Frame = +3 Query: 60 LGLARGLLYLHEESPVKIIHRDIKASNVLLDEKLNP-KISDFGMARLFLEDATHVNTFRI 236 L ++G+ YLH P +IHRD+K N+LL KI DFG A + TH+ + Sbjct: 135 LQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA---CDIQTHMTNNK- 190 Query: 237 SGTYGYMAPEYAMNGYLSTKTDVFSFGMLVLEIVSGRKNID 359 G+ +MAPE S K DVFS+G+++ E+++ RK D Sbjct: 191 -GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFD 230 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 76,077,199 Number of Sequences: 219361 Number of extensions: 1642440 Number of successful extensions: 9489 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 8095 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8681 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 5158951200 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
