ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags36m18 |
|---|---|
| Clone Library Name | barley_pub |
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 367 bits (941), Expect = e-101 Identities = 173/215 (80%), Positives = 203/215 (94%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 KGE+KGQ VAVK+I KAKMTTAI+IEDVRREVKIL+AL+GHNNLV+FYDA ED NVY+V Sbjct: 169 KGEFKGQDVAVKVIPKAKMTTAIAIEDVRREVKILRALTGHNNLVQFYDAFEDHTNVYVV 228 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 MELCEGGELLDRIL+RGG+YTE+DAKA+++QIL+VVAFCHLQGVVHRDLKPENFLF ++D Sbjct: 229 MELCEGGELLDRILSRGGKYTEDDAKAVMIQILNVVAFCHLQGVVHRDLKPENFLFKSKD 288 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCG 542 E++ +K IDFGLSD+++PDERLNDIVGSAYYVAPEVLHRSYS EAD+WSIGVI+YILLCG Sbjct: 289 EDSQLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRSYSTEADVWSIGVISYILLCG 348 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 SRPFWARTESGIFR+VL+A+ + D+ PWPSVS+EA Sbjct: 349 SRPFWARTESGIFRAVLKANLSFDEPPWPSVSSEA 383
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 232 bits (592), Expect = 6e-61 Identities = 114/210 (54%), Positives = 146/210 (69%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K ISK K+ + ED+RRE++I++ LSG N+V+F A ED NV++VMELC Sbjct: 108 GKQYACKSISKRKLVSKADKEDIRREIQIMQHLSGQQNIVEFRGAYEDKSNVHVVMELCA 167 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+A+G Y+E A I +++VV CH GV+HRDLKPENFL T++ENA + Sbjct: 168 GGELFDRIIAKG-HYSERAAATICRAVVNVVNICHFMGVMHRDLKPENFLLATKEENAML 226 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K DFGLS FI + DIVGSAYYVAPEVL R+Y E D+WS GVI YILL G PFW Sbjct: 227 KATDFGLSVFIEEGKMYRDIVGSAYYVAPEVLRRNYGKEIDVWSAGVILYILLSGVPPFW 286 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A TE GIF ++L+ + + + PWPS+S A Sbjct: 287 AETEKGIFDAILQGEIDFESQPWPSISESA 316
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 230 bits (586), Expect = 3e-60 Identities = 115/210 (54%), Positives = 143/210 (68%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K ISK K+ + ED+RRE++I++ LSG N+V+F A ED NV++VMELC Sbjct: 88 GRQYACKSISKRKLVSKADREDIRREIQIMQHLSGQPNIVEFRGAYEDKSNVHVVMELCA 147 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+A+G YTE A I +++VV CH GV+HRDLKPENFL T +ENA + Sbjct: 148 GGELFDRIIAKG-HYTERAAATICRAVVNVVNICHFMGVMHRDLKPENFLLATMEENAML 206 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K DFGLS FI + DIVGSAYYVAPEVL RSY E D+WS GVI YILL G PFW Sbjct: 207 KATDFGLSVFIEEGKMYRDIVGSAYYVAPEVLRRSYGKEIDVWSAGVILYILLSGVPPFW 266 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A E GIF ++L + + + PWPS+S A Sbjct: 267 AEIEKGIFDAILHEEIDFESQPWPSISESA 296
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 227 bits (579), Expect = 2e-59 Identities = 112/210 (53%), Positives = 141/210 (67%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K I+K K+ T +EDVRRE++I+ L+GH N++ A ED + V++VME C Sbjct: 173 GKEFACKSIAKRKLLTDEDVEDVRREIQIMHHLAGHPNVISIKGAYEDVVAVHLVMECCA 232 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+ RG YTE A + I+ VV CH GV+HRDLKPENFLF ++ E++ + Sbjct: 233 GGELFDRIIQRG-HYTERKAAELTRTIVGVVEACHSLGVMHRDLKPENFLFVSKHEDSLL 291 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K IDFGLS F +PD+ D+VGS YYVAPEVL + Y EAD+WS GVI YILL G PFW Sbjct: 292 KTIDFGLSMFFKPDDVFTDVVGSPYYVAPEVLRKRYGPEADVWSAGVIVYILLSGVPPFW 351 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A TE GIF VL D + PWPS+S A Sbjct: 352 AETEQGIFEQVLHGDLDFSSDPWPSISESA 381
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 219 bits (558), Expect = 5e-57 Identities = 113/210 (53%), Positives = 143/210 (68%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ A K I K K+ + ED++RE++IL+ LSG N+V+F ED +V++VMELC Sbjct: 104 GQLYACKSILKRKLVSKNDKEDIKREIQILQHLSGQPNIVEFKGVFEDRQSVHLVMELCA 163 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+A+G Y+E A I QI++VV CH GV+HRDLKPENFL +++D++A + Sbjct: 164 GGELFDRIIAQG-HYSERAAATICRQIVNVVHVCHFMGVMHRDLKPENFLLSSKDKDAML 222 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K DFGLS FI + +IVGSAYYVAPEVL RSY E DIWS GVI YILL G PFW Sbjct: 223 KATDFGLSVFIEEGKVYRNIVGSAYYVAPEVLRRSYGKEIDIWSAGVILYILLSGVPPFW 282 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A E GIF ++L + + PWPSVS A Sbjct: 283 AENEKGIFDAILEGVIDFESEPWPSVSNSA 312
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 219 bits (558), Expect = 5e-57 Identities = 108/210 (51%), Positives = 139/210 (66%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A K I K K+ T +EDVRRE++I+ LSGH N+V D ED V+IVMELC Sbjct: 102 GCEYACKTIPKRKLITKEDVEDVRREIQIMHHLSGHKNVVAIKDVYEDGQAVHIVMELCA 161 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI +G Y+E A ++ I+S+VA CH GV+HRDLKPENFL +D++ + Sbjct: 162 GGELFDRIQEKG-HYSERKAAELIRIIVSIVAMCHSLGVMHRDLKPENFLLLDKDDDLSI 220 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K IDFGLS F +P + ++VGS YYVAPEVLH+ Y E+D+WS GVI Y+LL G PFW Sbjct: 221 KAIDFGLSVFFKPGQVFTELVGSPYYVAPEVLHKRYGPESDVWSAGVILYVLLSGVPPFW 280 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A T+ GIF +VL+ + PWP +S A Sbjct: 281 AETQQGIFDAVLKGHIDFQSDPWPKISDSA 310
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 212 bits (540), Expect = 7e-55 Identities = 109/210 (51%), Positives = 136/210 (64%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A K I K K+ EDV RE++I+ LS H N+V+ ED+ V++VMELCE Sbjct: 57 GGKFACKSIPKRKLLCKEDYEDVWREIQIMHHLSEHANVVRIEGTYEDSTAVHLVMELCE 116 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+ +G Y+E A ++ I+ VV CH GV+HRDLKPENFLF T DE+A + Sbjct: 117 GGELFDRIVQKG-HYSERQAARLIKTIVEVVEACHSLGVMHRDLKPENFLFDTIDEDAKL 175 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K DFGLS F +P E D+VGS YYVAPEVL + Y E+D+WS GVI YILL G PFW Sbjct: 176 KATDFGLSVFYKPGESFCDVVGSPYYVAPEVLRKLYGPESDVWSAGVILYILLSGVPPFW 235 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A +E GIFR +L + PWPS+S A Sbjct: 236 AESEPGIFRQILLGKLDFHSEPWPSISDSA 265
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 198 bits (504), Expect = 1e-50 Identities = 101/210 (48%), Positives = 130/210 (61%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A K I K+ + IEDVRRE++I+ LSG N+V D ED V+IVMELC Sbjct: 96 GCQYACKTILKSNLRCVSDIEDVRREIQIMHHLSGQKNIVTIKDTYEDEQAVHIVMELCA 155 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL +I RG Y+E A ++ I+ ++ CH GV+HRDLKPENFL D+ + Sbjct: 156 GGELFSKIQKRG-HYSERKAAELIKIIVGIIETCHSHGVMHRDLKPENFLLLDADDEFSV 214 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFW 557 K IDFGLS F RP + ++VGS YY+APEVL + Y EADIW+ GVI Y+LL G PFW Sbjct: 215 KAIDFGLSVFFRPGQVFREVVGSPYYIAPEVLEKRYGPEADIWTAGVILYVLLTGVPPFW 274 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 A T+SGI+ VL + + WP +S A Sbjct: 275 ADTQSGIYEKVLDGRIDFKSNRWPRISDSA 304
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 163 bits (412), Expect = 5e-40 Identities = 86/218 (39%), Positives = 129/218 (59%), Gaps = 12/218 (5%) Frame = +3 Query: 30 AVKIISKAK-------MTTAISIED-----VRREVKILKALSGHNNLVKFYDACEDALNV 173 A+K+I K++ +T I +D + E+ +LK+L H N++K +D ED Sbjct: 82 AIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKSLD-HPNIIKLFDVFEDKKYF 140 Query: 174 YIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT 353 Y+V E EGGEL ++I+ R ++ E DA I+ QILS + + H +VHRD+KPEN L Sbjct: 141 YLVTEFYEGGELFEQIINRH-KFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLE 199 Query: 354 TRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYIL 533 + +K++DFGLS F D +L D +G+AYY+APEVL + Y+ + D+WS GVI YIL Sbjct: 200 NKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVILYIL 259 Query: 534 LCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 LCG PF + + I + V + D + W ++S EA Sbjct: 260 LCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEA 297
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 163 bits (412), Expect = 5e-40 Identities = 86/218 (39%), Positives = 129/218 (59%), Gaps = 12/218 (5%) Frame = +3 Query: 30 AVKIISKAK-------MTTAISIED-----VRREVKILKALSGHNNLVKFYDACEDALNV 173 A+K+I K++ +T I +D + E+ +LK+L H N++K +D ED Sbjct: 82 AIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKSLD-HPNIIKLFDVFEDKKYF 140 Query: 174 YIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT 353 Y+V E EGGEL ++I+ R ++ E DA I+ QILS + + H +VHRD+KPEN L Sbjct: 141 YLVTEFYEGGELFEQIINRH-KFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLE 199 Query: 354 TRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYIL 533 + +K++DFGLS F D +L D +G+AYY+APEVL + Y+ + D+WS GVI YIL Sbjct: 200 NKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVILYIL 259 Query: 534 LCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 LCG PF + + I + V + D + W ++S EA Sbjct: 260 LCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEA 297
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 162 bits (409), Expect = 1e-39 Identities = 80/190 (42%), Positives = 119/190 (62%) Frame = +3 Query: 78 EDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDA 257 E++ E+ +LK+L H N++K +D ED Y+V E EGGEL ++I+ R ++ E DA Sbjct: 109 EEIYNEISLLKSLD-HPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH-KFDECDA 166 Query: 258 KAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLNDI 437 I+ QILS + + H +VHRD+KPEN L ++ +K++DFGLS F D +L D Sbjct: 167 ANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDR 226 Query: 438 VGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLRADPNLDD 617 +G+AYY+APEVL + Y+ + D+WS GVI YILLCG PF + + I + V + D Sbjct: 227 LGTAYYIAPEVLKKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDF 286 Query: 618 SPWPSVSAEA 647 + W ++S EA Sbjct: 287 NDWKNISDEA 296
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 161 bits (407), Expect = 2e-39 Identities = 92/216 (42%), Positives = 126/216 (58%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K G+ A+K I K+ S+E+ E+ +LK + H N+V D E + Y+V Sbjct: 41 KQRVTGKLFALKCIKKSPAFRDSSLEN---EIAVLKRIK-HENIVTLEDIYESTTHYYLV 96 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 M+L GGEL DRIL RG YTE+DA ++ Q+LS V + H G+VHRDLKPEN L+ T + Sbjct: 97 MQLVSGGELFDRILERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPE 155 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLC 539 EN+ + + DFGLS + + ++ G+ YVAPEVL + YS D WSIGVITYILLC Sbjct: 156 ENSKIMITDFGLSK-MEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLC 214 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF+ TES +F + + W +S A Sbjct: 215 GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESA 250
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 161 bits (407), Expect = 2e-39 Identities = 92/216 (42%), Positives = 126/216 (58%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K G+ A+K I K+ S+E+ E+ +LK + H N+V D E + Y+V Sbjct: 41 KQRLTGKLFALKCIKKSPAFRDSSLEN---EIAVLKKIK-HENIVTLEDIYESTTHYYLV 96 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 M+L GGEL DRIL RG YTE+DA ++ Q+LS V + H G+VHRDLKPEN L+ T + Sbjct: 97 MQLVSGGELFDRILERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPE 155 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLC 539 EN+ + + DFGLS + + ++ G+ YVAPEVL + YS D WSIGVITYILLC Sbjct: 156 ENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLC 214 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF+ TES +F + + W +S A Sbjct: 215 GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESA 250
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 161 bits (407), Expect = 2e-39 Identities = 92/216 (42%), Positives = 126/216 (58%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K G+ A+K I K+ S+E+ E+ +LK + H N+V D E + Y+V Sbjct: 41 KQRVTGKLFALKCIKKSPAFRDSSLEN---EIAVLKRIK-HENIVTLEDIYESTTHYYLV 96 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 M+L GGEL DRIL RG YTE+DA ++ Q+LS V + H G+VHRDLKPEN L+ T + Sbjct: 97 MQLVSGGELFDRILERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPE 155 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLC 539 EN+ + + DFGLS + + ++ G+ YVAPEVL + YS D WSIGVITYILLC Sbjct: 156 ENSKIMITDFGLSK-MEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLC 214 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF+ TES +F + + W +S A Sbjct: 215 GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESA 250
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 158 bits (400), Expect = 1e-38 Identities = 88/216 (40%), Positives = 128/216 (59%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K ++ G A+K+ISK + + + REV++LK L H N++K Y+ ED Y+V Sbjct: 87 KDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLD-HINIMKLYEFFEDNNYYYLV 145 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL D I++R R+ E DA I+ Q+LS + + H VVHRDLKPEN L T++ Sbjct: 146 SDVYSGGELFDEIISRK-RFYEVDAARIIKQVLSGITYMHKNNVVHRDLKPENILLETKN 204 Query: 363 -ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLC 539 E+ +K+IDFGLS +++ D +G+AYY+AP+VLH +Y + DIWS GVI YILL Sbjct: 205 KEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLS 264 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF E I + V D + +S +A Sbjct: 265 GCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKA 300
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 158 bits (400), Expect = 1e-38 Identities = 88/216 (40%), Positives = 128/216 (59%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K ++ G A+K+ISK + + + REV++LK L H N++K Y+ ED Y+V Sbjct: 87 KDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLD-HINIMKLYEFFEDNNYYYLV 145 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL D I++R R+ E DA I+ Q+LS + + H VVHRDLKPEN L T++ Sbjct: 146 SDVYSGGELFDEIISRK-RFYEVDAARIIKQVLSGITYMHKNNVVHRDLKPENILLETKN 204 Query: 363 -ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLC 539 E+ +K+IDFGLS +++ D +G+AYY+AP+VLH +Y + DIWS GVI YILL Sbjct: 205 KEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLS 264 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF E I + V D + +S +A Sbjct: 265 GCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKA 300
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 158 bits (400), Expect = 1e-38 Identities = 86/211 (40%), Positives = 124/211 (58%), Gaps = 1/211 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ AVK I K + S + E+ +L+ + H N+V D E ++Y+VM+L Sbjct: 46 GKLFAVKCIPKKALKGKES--SIENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVS 102 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+ +G YTE+DA ++ Q+L V + H G+VHRDLKPEN L+ ++DE + + Sbjct: 103 GGELFDRIVEKGF-YTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKI 161 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 + DFGLS + ++ G+ YVAPEVL + YS D WSIGVI YILLCG PF Sbjct: 162 MISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPF 221 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +S +F +L+A+ D W +S A Sbjct: 222 YDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 158 bits (400), Expect = 1e-38 Identities = 86/211 (40%), Positives = 124/211 (58%), Gaps = 1/211 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ AVK I K + S + E+ +L+ + H N+V D E ++Y+VM+L Sbjct: 46 GKLFAVKCIPKKALKGKES--SIENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVS 102 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+ +G YTE+DA ++ Q+L V + H G+VHRDLKPEN L+ ++DE + + Sbjct: 103 GGELFDRIVEKGF-YTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKI 161 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 + DFGLS + ++ G+ YVAPEVL + YS D WSIGVI YILLCG PF Sbjct: 162 MISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPF 221 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +S +F +L+A+ D W +S A Sbjct: 222 YDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 158 bits (399), Expect = 2e-38 Identities = 89/216 (41%), Positives = 128/216 (59%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 + ++ G A+K+ISK + E + REV++LK L H N++K Y+ ED Y+V Sbjct: 87 RDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD-HINIMKLYEFFEDNNYYYLV 145 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL D I++R R+ E DA I+ QILS + + H VVHRDLKPEN L T++ Sbjct: 146 SDVYTGGELFDEIISRK-RFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKN 204 Query: 363 -ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLC 539 E+ +K+IDFGLS +++ D +G+AYY+AP+VLH +Y + DIWS GVI YILL Sbjct: 205 KEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLS 264 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF E I + V D + +S +A Sbjct: 265 GCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKA 300
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 157 bits (398), Expect = 2e-38 Identities = 85/215 (39%), Positives = 129/215 (60%), Gaps = 3/215 (1%) Frame = +3 Query: 12 YKG---QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 YKG T + I + K +I +E++I+K L H N+VK Y+ E+ +Y++ Sbjct: 86 YKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLD-HPNIVKLYETYENDNYIYLI 144 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 MELC G EL D I+ G +TE++A I+ QI S + + H +VHRDLKPENFLF + + Sbjct: 145 MELCSGRELFDSIIENGS-FTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSEN 203 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCG 542 +++ +K+IDFGLS + E G+ YYVAP+VL Y + DIWS GVI Y LLCG Sbjct: 204 KDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSGVIMYTLLCG 263 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 PF+ T++ + + V + + ++ W S+S++A Sbjct: 264 YPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDA 298
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 157 bits (398), Expect = 2e-38 Identities = 85/215 (39%), Positives = 129/215 (60%), Gaps = 3/215 (1%) Frame = +3 Query: 12 YKG---QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 YKG T + I + K +I +E++I+K L H N+VK Y+ E+ +Y++ Sbjct: 86 YKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLD-HPNIVKLYETYENDNYIYLI 144 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 MELC G EL D I+ G +TE++A I+ QI S + + H +VHRDLKPENFLF + + Sbjct: 145 MELCSGRELFDSIIENGS-FTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSEN 203 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCG 542 +++ +K+IDFGLS + E G+ YYVAP+VL Y + DIWS GVI Y LLCG Sbjct: 204 KDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSGVIMYTLLCG 263 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 PF+ T++ + + V + + ++ W S+S++A Sbjct: 264 YPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDA 298
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 157 bits (396), Expect = 3e-38 Identities = 81/207 (39%), Positives = 125/207 (60%), Gaps = 1/207 (0%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK++SK K+ +I R+E+ I+K L H N++K + ED +Y++M+LC GGEL Sbjct: 139 AVKVVSKKKLK---NIPRFRQEIDIMKNLD-HPNVIKLLETFEDEEQIYLIMDLCTGGEL 194 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 D+I+ +G + E A I+ QI SV+ + H++ + HRD+KPENFLF + + +K+ID Sbjct: 195 FDKIIKKGS-FVEMYASFIMKQIFSVLNYLHIRNICHRDIKPENFLFYDKSTESLIKIID 253 Query: 390 FGLSDFIRP-DERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFWART 566 FGL+ + D + G+ YYVAP+VL Y + D+WS GV+ YI+LCG PF+ + Sbjct: 254 FGLAAYFNDIDYEMKTKAGTPYYVAPQVLTGCYDYKCDLWSAGVLFYIILCGYPPFYGES 313 Query: 567 ESGIFRSVLRADPNLDDSPWPSVSAEA 647 + I V + N W ++S EA Sbjct: 314 DHEILSMVKKGKYNFKGKEWNNISDEA 340
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 156 bits (394), Expect = 6e-38 Identities = 85/207 (41%), Positives = 126/207 (60%), Gaps = 1/207 (0%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK++SK K+ +I R+E+ I+K L H N+VK + ED+ +Y+VMELC GGEL Sbjct: 145 AVKVVSKKKLK---NIPRFRQEIDIMKNLD-HPNVVKLLETFEDSNQIYLVMELCTGGEL 200 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 D+I+ +G + E A I+ QI SV+ + H++ + HRD+KPENFLF + +K+ID Sbjct: 201 FDKIVKKGC-FVETFASFIMKQIFSVLNYLHIRNICHRDIKPENFLFYDMTPESLIKIID 259 Query: 390 FGLSD-FIRPDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSRPFWART 566 FGL+ F + + G+ YYVAP+VL SY+ + D+WS GV+ YILLCG PF+ + Sbjct: 260 FGLASYFTHNNYEMKTKAGTPYYVAPQVLTGSYNYKCDMWSSGVLFYILLCGYPPFFGES 319 Query: 567 ESGIFRSVLRADPNLDDSPWPSVSAEA 647 + I V + W ++S EA Sbjct: 320 DHEILSMVKKGKYQFKGKEWNNISEEA 346
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 153 bits (387), Expect = 4e-37 Identities = 84/208 (40%), Positives = 121/208 (58%), Gaps = 1/208 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K I+K + + E+ +L + H N+V D E ++Y++M+L GGE Sbjct: 46 VAIKCIAKEALEGKEG--SMENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGE 102 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI+ +G YTE DA ++ Q+L V + H G+VHRDLKPEN L+ + DE++ + + Sbjct: 103 LFDRIVEKGF-YTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMIS 161 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGLS P L+ G+ YVAPEVL + YS D WSIGVI YILLCG PF+ Sbjct: 162 DFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE 221 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +F +L+A+ D W +S A Sbjct: 222 NDAKLFEQILKAEYEFDSPYWDDISDSA 249
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 153 bits (387), Expect = 4e-37 Identities = 84/208 (40%), Positives = 121/208 (58%), Gaps = 1/208 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K I+K + + E+ +L + H N+V D E ++Y++M+L GGE Sbjct: 46 VAIKCIAKKALEGKEG--SMENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGE 102 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI+ +G YTE DA ++ Q+L V + H G+VHRDLKPEN L+ + DE++ + + Sbjct: 103 LFDRIVEKGF-YTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMIS 161 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGLS P L+ G+ YVAPEVL + YS D WSIGVI YILLCG PF+ Sbjct: 162 DFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE 221 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +F +L+A+ D W +S A Sbjct: 222 NDAKLFEQILKAEYEFDSPYWDDISDSA 249
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 153 bits (387), Expect = 4e-37 Identities = 84/208 (40%), Positives = 121/208 (58%), Gaps = 1/208 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K I+K + + E+ +L + H N+V D E ++Y++M+L GGE Sbjct: 46 VAIKCIAKKALEGKEG--SMENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGE 102 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI+ +G YTE DA ++ Q+L V + H G+VHRDLKPEN L+ + DE++ + + Sbjct: 103 LFDRIVEKGF-YTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMIS 161 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGLS P L+ G+ YVAPEVL + YS D WSIGVI YILLCG PF+ Sbjct: 162 DFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE 221 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +F +L+A+ D W +S A Sbjct: 222 NDAKLFEQILKAEYEFDSPYWDDISDSA 249
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 153 bits (386), Expect = 5e-37 Identities = 86/208 (41%), Positives = 124/208 (59%), Gaps = 1/208 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K I K + ++ V E+ +L+ +S H N+V D E ++Y+ MEL GGE Sbjct: 41 VALKCIPKKALRGKEAL--VENEIAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGGE 97 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI+ RG YTE+DA +V Q+L V++ H G+VHRDLKPEN L+ T E++ + + Sbjct: 98 LFDRIMERGS-YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVS 156 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGLS I+ L G+ YVAPE+L + Y D+W++GVI+YILLCG PF+ Sbjct: 157 DFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDE 215 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +F +LRA D W +S A Sbjct: 216 SDPELFSQILRASYEFDSPFWDDISESA 243
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 153 bits (386), Expect = 5e-37 Identities = 86/208 (41%), Positives = 124/208 (59%), Gaps = 1/208 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K I K + ++ V E+ +L+ +S H N+V D E ++Y+ MEL GGE Sbjct: 41 VALKCIPKKALRGKEAL--VENEIAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGGE 97 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI+ RG YTE+DA +V Q+L V++ H G+VHRDLKPEN L+ T E++ + + Sbjct: 98 LFDRIMERGS-YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVS 156 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGLS I+ L G+ YVAPE+L + Y D+W++GVI+YILLCG PF+ Sbjct: 157 DFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDE 215 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +F +LRA D W +S A Sbjct: 216 SDPELFSQILRASYEFDSPFWDDISESA 243
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 153 bits (386), Expect = 5e-37 Identities = 86/208 (41%), Positives = 124/208 (59%), Gaps = 1/208 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K I K + ++ V E+ +L+ +S H N+V D E ++Y+ MEL GGE Sbjct: 41 VALKCIPKKALRGKEAL--VENEIAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGGE 97 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI+ RG YTE+DA +V Q+L V++ H G+VHRDLKPEN L+ T E++ + + Sbjct: 98 LFDRIMERGS-YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVS 156 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGLS I+ L G+ YVAPE+L + Y D+W++GVI+YILLCG PF+ Sbjct: 157 DFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDE 215 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +F +LRA D W +S A Sbjct: 216 SDPELFSQILRASYEFDSPFWDDISESA 243
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 151 bits (382), Expect = 1e-36 Identities = 85/208 (40%), Positives = 122/208 (58%), Gaps = 2/208 (0%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+K++ K + + VR E+ +L LS H N++K + E + +V+EL GGEL Sbjct: 69 ALKVLKKT-----VDKKIVRTEIGVLLRLS-HPNIIKLKEIFETPTEISLVLELVTGGEL 122 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 DRI+ +G Y+E DA+ V QIL VA+ H G+VHRDLKPEN L+ T +AP+K+ D Sbjct: 123 FDRIVEKG-YYSERDARDAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIAD 181 Query: 390 FGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFW-AR 563 FGLS + + + G+ Y APE+L +Y E D+WS+G+ITYILLCG PF+ R Sbjct: 182 FGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDER 241 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +FR +L + W VS A Sbjct: 242 GDQFMFRRILNCEYYFISPWWDEVSLNA 269
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 150 bits (379), Expect = 3e-36 Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 2/208 (0%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+K++ K + + VR E+ +L LS H N++K + E + +V+EL GGEL Sbjct: 73 ALKVLKKT-----VDKKIVRTEIGVLLRLS-HPNIIKLKEIFETPTEISLVLELVTGGEL 126 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 DRI+ +G Y+E DA V QIL VA+ H G+VHRDLKPEN L+ T +AP+K+ D Sbjct: 127 FDRIVEKG-YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIAD 185 Query: 390 FGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFW-AR 563 FGLS + + + G+ Y APE+L +Y E D+WS+G+ITYILLCG PF+ R Sbjct: 186 FGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDER 245 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +FR +L + W VS A Sbjct: 246 GDQFMFRRILNCEYYFISPWWDEVSLNA 273
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 150 bits (379), Expect = 3e-36 Identities = 83/210 (39%), Positives = 127/210 (60%), Gaps = 1/210 (0%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A+K+I+K+++ ++++ EV ILK ++ H N++ + + +Y+VMEL G Sbjct: 32 QRYAIKVINKSELGKDYE-KNLKMEVDILKKVN-HPNIIALKELFDTPEKLYLVMELVTG 89 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL D+I+ +G Y+E DA +V +I+S V + H +VHRDLKPEN L +++ + + Sbjct: 90 GELFDKIVEKGS-YSEADAANLVKKIVSAVGYLHGLNIVHRDLKPENLLLKSKENHLEVA 148 Query: 381 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFW 557 + DFGLS I + G+ YVAPEVL+ + Y E D+WSIGVITYILLCG PF+ Sbjct: 149 IADFGLSKIIGQTLVMQTACGTPSYVAPEVLNATGYDKEVDMWSIGVITYILLCGFPPFY 208 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 T IF ++ A+ + W +S EA Sbjct: 209 GDTVPEIFEQIMEANYEFPEEYWGGISKEA 238
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 150 bits (379), Expect = 3e-36 Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 2/208 (0%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+K++ K + + VR E+ +L LS H N++K + E + +V+EL GGEL Sbjct: 69 ALKVLKKT-----VDKKIVRTEIGVLLRLS-HPNIIKLKEIFETPTEISLVLELVTGGEL 122 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 DRI+ +G Y+E DA V QIL VA+ H G+VHRDLKPEN L+ T +AP+K+ D Sbjct: 123 FDRIVEKG-YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIAD 181 Query: 390 FGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFW-AR 563 FGLS + + + G+ Y APE+L +Y E D+WS+G+ITYILLCG PF+ R Sbjct: 182 FGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDER 241 Query: 564 TESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +FR +L + W VS A Sbjct: 242 GDQFMFRRILNCEYYFISPWWDEVSLNA 269
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 150 bits (378), Expect = 4e-36 Identities = 88/188 (46%), Positives = 118/188 (62%), Gaps = 3/188 (1%) Frame = +3 Query: 21 QTVAVKII-SKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 + VA+KI+ KA + ++ + E+ IL+ LS H N+V F D E YIV +L Sbjct: 71 EDVAIKILLKKALQGNNVQLQMLYEELSILQKLS-HPNIVSFKDWFESKDKFYIVTQLAT 129 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRIL+RG ++TE DA I+VQIL V + H + VVHRDLKPEN L+ + EN+P+ Sbjct: 130 GGELFDRILSRG-KFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPL 188 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRP 551 + DFG++ ++ +E L GS YVAPEVL + + DIWSIGVITY LLCG P Sbjct: 189 VIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSP 248 Query: 552 FWARTESG 575 F A + G Sbjct: 249 FIAESVEG 256
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 147 bits (370), Expect = 3e-35 Identities = 88/189 (46%), Positives = 117/189 (61%), Gaps = 3/189 (1%) Frame = +3 Query: 3 KGEYKGQTVAVKI-ISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYI 179 K G+ VAVKI I KA + +E + E+ IL+ L H N+V F D E YI Sbjct: 55 KNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLH-HPNIVAFKDWFESKDKFYI 113 Query: 180 VMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR 359 + +L +GGEL DRIL +G ++TEEDA I+V+ILS V + H Q +VHRDLKPEN L+ + Sbjct: 114 ITQLAKGGELFDRILKKG-KFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDK 172 Query: 360 DENAPMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYIL 533 + +P+ + DFG++ ++ DE L GS YVAPEVL + + DIWSIGVITY L Sbjct: 173 SDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTL 232 Query: 534 LCGSRPFWA 560 LCG F A Sbjct: 233 LCGYSAFRA 241
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 142 bits (357), Expect = 1e-33 Identities = 83/218 (38%), Positives = 125/218 (57%), Gaps = 9/218 (4%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q AVKIISK + +RE+ LK GH N+VK ++ D L+ ++VMEL +G Sbjct: 440 QEYAVKIISKRMEA------NTQREITALKLCEGHPNVVKLHEVYHDQLHTFLVMELLKG 493 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GELL+RI + ++E +A I+ +++S V+ H GVVHRDLKPEN LFT +N+ +K Sbjct: 494 GELLERIQKKQ-HFSETEASHIMRRLVSAVSHMHDVGVVHRDLKPENLLFTDETDNSEIK 552 Query: 381 LIDFGLSDFIRPDER-LNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 +IDFG + PD + L + +Y APE+ H Y D+WS+GVI Y +L G PF Sbjct: 553 IIDFGFARLKPPDNQPLKTPCFTLHYAAPELFNHNGYDESCDLWSLGVILYTMLSGQVPF 612 Query: 555 WARTES-------GIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +S I + + + + + + W +VS EA Sbjct: 613 QSQDKSLTCTSALEIMKKIKKGEFSFEGEAWKNVSEEA 650 Score = 88.6 bits (218), Expect = 1e-17 Identities = 59/210 (28%), Positives = 108/210 (51%), Gaps = 10/210 (4%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTT-AISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 G G+ A+K++ KA + A + E R E ++L+ + LV + A + ++++ Sbjct: 61 GHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTDTKLHLI 120 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL + R R++E + + + +I+ + H G+++RD+K EN L D Sbjct: 121 LDYINGGELFTHLSQRE-RFSENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILL---D 176 Query: 363 ENAPMKLIDFGLSDFIRPD--ERLNDIVGSAYYVAPEVLH---RSYSMEADIWSIGVITY 527 + + L DFGLS D ER G+ Y+AP+++ + D WS+GV+ Y Sbjct: 177 SDGHVVLTDFGLSKEFLTDENERAYSFCGTIEYMAPDIVRGGDTGHDKAVDWWSVGVLMY 236 Query: 528 ILLCGSRPFWA----RTESGIFRSVLRADP 605 LL G+ PF +++ I R +L+++P Sbjct: 237 ELLTGASPFTVDGEKNSQAEISRRILKSEP 266
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 141 bits (356), Expect = 1e-33 Identities = 75/203 (36%), Positives = 124/203 (61%), Gaps = 1/203 (0%) Frame = +3 Query: 42 ISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRI 221 + + ++ A+ ++ +I++ +S H N++ +D EDA V++V+ELC GGEL DRI Sbjct: 74 LKQVSVSDALLTNEILVMRRIVEDVSPHPNVIHLHDVYEDANGVHLVLELCSGGELFDRI 133 Query: 222 LARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLS 401 +A+ RY+E +A +V QI S +A H ++HRDLKPEN LF +++ + +K++DFGLS Sbjct: 134 VAQD-RYSESEAAEVVQQIASGLAALHKSTIIHRDLKPENCLFLNQEKRSTLKIMDFGLS 192 Query: 402 DFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGI 578 + + + GS YV+PE L R S +D+WS+GVI YILL G PF A + Sbjct: 193 SVEDFTDPIVALFGSIDYVSPEALSQRQVSSASDMWSLGVILYILLSGCPPFHAPSNREK 252 Query: 579 FRSVLRADPNLDDSPWPSVSAEA 647 + +L D + ++ W ++++ A Sbjct: 253 QQRILAGDFSFEEHTWKTITSSA 275
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 140 bits (352), Expect = 4e-33 Identities = 82/218 (37%), Positives = 124/218 (56%), Gaps = 9/218 (4%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q AVKIISK + ++E+ LK GH N+VK ++ D L+ ++VMEL G Sbjct: 450 QAFAVKIISKRMEA------NTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNG 503 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL +RI + ++E +A I+ +++S V+ H GVVHRDLKPEN LFT ++N +K Sbjct: 504 GELFERIKKKK-HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIK 562 Query: 381 LIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 +IDFG + PD + L + +Y APE+L+++ Y D+WS+GVI Y +L G PF Sbjct: 563 IIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPF 622 Query: 555 WARTES-------GIFRSVLRADPNLDDSPWPSVSAEA 647 + S I + + + D + + W +VS EA Sbjct: 623 QSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660 Score = 92.8 bits (229), Expect = 8e-19 Identities = 62/210 (29%), Positives = 111/210 (52%), Gaps = 10/210 (4%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTT-AISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 G G+ A+K++ KA + A + E R E ++L+ + LV + A + ++++ Sbjct: 71 GHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLI 130 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL + R R+TE + + V +I+ + H G+++RD+K EN L D Sbjct: 131 LDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL---D 186 Query: 363 ENAPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLH---RSYSMEADIWSIGVITY 527 N + L DFGLS +F+ + ER G+ Y+AP+++ + D WS+GV+ Y Sbjct: 187 SNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMY 246 Query: 528 ILLCGSRPFWA----RTESGIFRSVLRADP 605 LL G+ PF +++ I R +L+++P Sbjct: 247 ELLTGASPFTVDGEKNSQAEISRRILKSEP 276
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 139 bits (351), Expect = 6e-33 Identities = 75/201 (37%), Positives = 125/201 (62%), Gaps = 6/201 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISI-EDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELC 194 GQ+VAVKI++K K+ T ++ +++RE+ I++ LS H N+VK ++ ++ ME Sbjct: 44 GQSVAVKILNKKKLLTNPALANNIKREISIMRRLS-HPNIVKLHEVMATKSKIFFAMEFV 102 Query: 195 EGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 +GGEL ++I ++ GR +E+ ++ Q++S V +CH +GV HRDLKPEN L DEN Sbjct: 103 KGGELFNKI-SKHGRLSEDLSRRYFQQLISAVGYCHARGVYHRDLKPENLLI---DENGN 158 Query: 375 MKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYILLC 539 +K+ DFGLS D IRPD L+ + G+ YVAPE+L + + D+WS G++ ++L+ Sbjct: 159 LKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILSKKGYEGAKVDVWSCGIVLFVLVA 218 Query: 540 GSRPFWARTESGIFRSVLRAD 602 G PF +++ + + + Sbjct: 219 GYLPFNDPNVMNMYKKIYKGE 239
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 139 bits (350), Expect = 7e-33 Identities = 79/193 (40%), Positives = 111/193 (57%), Gaps = 2/193 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G VA+KI+++ K+ E VRRE+KIL+ L H ++++ Y+ E ++Y+VME Sbjct: 65 GHKVAIKILNRRKIKNMEMEEKVRREIKILR-LFMHPHIIRLYEVIETPTDIYLVMEYVN 123 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GEL D I+ +G R E++A+ QI+S V +CH VVHRDLKPEN L D + Sbjct: 124 SGELFDYIVEKG-RLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLL---DSKCNV 179 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRP 551 K+ DFGLS+ +R L GS Y APEV+ E D+WS GVI Y LLCG+ P Sbjct: 180 KIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLP 239 Query: 552 FWARTESGIFRSV 590 F +F+ + Sbjct: 240 FDDENIPNLFKKI 252
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 139 bits (349), Expect = 9e-33 Identities = 82/210 (39%), Positives = 117/210 (55%), Gaps = 4/210 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALS-GHNNLVKFYDACEDALNVYIVMELCEGGE 206 A KI++K M V+ E+ ILK +S H N++ D E N+Y++ EL GGE Sbjct: 58 AAKIMNKKMMEKKQDF--VKNEIAILKRVSYEHPNILHLVDFFETVNNLYLITELATGGE 115 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI A+G Y E DA A++ S V + H G+VHRDLKPEN L+ ++D N+ + + Sbjct: 116 LFDRICAKGSFY-EADAAALMRTTTSAVKYLHDNGIVHRDLKPENLLYRSKDPNSDLLIA 174 Query: 387 DFGLSDFIRPDE--RLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFW 557 DFGLS F + L G+ Y+APEV R+ Y D+W+IGVITY LL G PF Sbjct: 175 DFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGVITYFLLSGYTPFA 234 Query: 558 ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ + ++L + +D W +S A Sbjct: 235 RPSQVEVIEAILANEYTFNDPCWSGISETA 264
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 138 bits (348), Expect = 1e-32 Identities = 80/212 (37%), Positives = 122/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ A KII+ K++ A + + RE +I + L H N+V+ +D+ + Y+V +L Sbjct: 37 GQEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVT 94 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CHL G+VHRDLKPEN L ++ + A + Sbjct: 95 GGELFEDIVARE-YYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAV 153 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ ++ D++ G+ Y++PEVL + Y D+W+ GVI YILL G P Sbjct: 154 KLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPP 213 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 214 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 245
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 138 bits (348), Expect = 1e-32 Identities = 82/218 (37%), Positives = 124/218 (56%), Gaps = 9/218 (4%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q AVKIISK + ++E+ LK GH N+VK ++ D L+ ++VMEL G Sbjct: 450 QAFAVKIISKRMEA------NTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNG 503 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL +RI + ++E +A I+ +++S V+ H GVVHRDLKPEN LFT ++N +K Sbjct: 504 GELFERIKKKK-HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIK 562 Query: 381 LIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 +IDFG + PD + L + +Y APE+L+++ Y D+WS+GVI Y +L G PF Sbjct: 563 IIDFGFARPKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPF 622 Query: 555 WARTES-------GIFRSVLRADPNLDDSPWPSVSAEA 647 + S I + + + D + + W +VS EA Sbjct: 623 QSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660 Score = 92.0 bits (227), Expect = 1e-18 Identities = 62/210 (29%), Positives = 110/210 (52%), Gaps = 10/210 (4%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTT-AISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 G G+ A+K++ KA + A + E R E ++L+ LV + A + ++++ Sbjct: 71 GHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHTRQSPFLVTLHYAFQTETKLHLI 130 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL + R R+TE + + V +I+ + H G+++RD+K EN L D Sbjct: 131 LDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL---D 186 Query: 363 ENAPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLH---RSYSMEADIWSIGVITY 527 N + L DFGLS +F+ + ER G+ Y+AP+++ + D WS+GV+ Y Sbjct: 187 SNGHVMLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMY 246 Query: 528 ILLCGSRPFWA----RTESGIFRSVLRADP 605 LL G+ PF +++ I R +L+++P Sbjct: 247 ELLTGASPFTVDGEKNSQAEISRRILKSEP 276
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 138 bits (348), Expect = 1e-32 Identities = 79/193 (40%), Positives = 112/193 (58%), Gaps = 2/193 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G VA+KI+++ K+ E VRRE+KIL+ L H ++++ Y+ E ++Y+VME + Sbjct: 43 GHKVAIKILNRRKIKNMEMEEKVRREIKILR-LFMHPHIIRQYEVIETTSDIYVVMEYVK 101 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GEL D I+ +G R E++A+ QI+S V +CH VVHRDLKPEN L D + Sbjct: 102 SGELFDYIVEKG-RLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLL---DSRCNI 157 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRP 551 K+ DFGLS+ +R L GS Y APEV+ E D+WS GVI Y LLCG+ P Sbjct: 158 KIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLP 217 Query: 552 FWARTESGIFRSV 590 F +F+ + Sbjct: 218 FDDENIPNLFKKI 230
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 138 bits (347), Expect = 2e-32 Identities = 80/212 (37%), Positives = 122/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ A KII+ K++ A + + RE +I + L H N+V+ +D+ + Y+V +L Sbjct: 37 GQGYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVT 94 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CHL G+VHRDLKPEN L ++ + A + Sbjct: 95 GGELFEDIVARE-YYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAV 153 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ ++ D++ G+ Y++PEVL + Y D+W+ GVI YILL G P Sbjct: 154 KLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPP 213 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 214 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 245
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 137 bits (345), Expect = 3e-32 Identities = 80/212 (37%), Positives = 122/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A KII+ K++ A + + RE +I + L H+N+V+ +D+ + Y+V +L Sbjct: 37 GHEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HSNIVRLHDSISEEGFHYLVFDLVT 94 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 95 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAV 153 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ ++ D++ G+ Y++PEVL + +Y DIW+ GVI YILL G P Sbjct: 154 KLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPP 213 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 245
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 137 bits (345), Expect = 3e-32 Identities = 80/212 (37%), Positives = 122/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A KII+ K++ A + + RE +I + L H+N+V+ +D+ + Y+V +L Sbjct: 37 GHEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HSNIVRLHDSISEEGFHYLVFDLVT 94 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 95 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAV 153 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ ++ D++ G+ Y++PEVL + +Y DIW+ GVI YILL G P Sbjct: 154 KLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPP 213 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 245
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 137 bits (345), Expect = 3e-32 Identities = 80/212 (37%), Positives = 122/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A KII+ K++ A + + RE +I + L H+N+V+ +D+ + Y+V +L Sbjct: 37 GHEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HSNIVRLHDSISEEGFHYLVFDLVT 94 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 95 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAV 153 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ ++ D++ G+ Y++PEVL + +Y DIW+ GVI YILL G P Sbjct: 154 KLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPP 213 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 245
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 136 bits (343), Expect = 5e-32 Identities = 76/178 (42%), Positives = 109/178 (61%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K ++ ++ ++E + REV+++K L+ H N++K Y E +YIV E + GE Sbjct: 53 VAIKIIDKTRLDSS-NLEKIYREVQLMKLLN-HPNIIKLYQVMETKDMLYIVTEFAKNGE 110 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D L G +E +A+ QILS V +CH +VHRDLK EN L D N +KL Sbjct: 111 MFD-YLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLL---DSNMDIKLA 166 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRPF 554 DFG +F +P E L+ VGS Y APEV + Y + D+WS+GV+ Y+L+CGS PF Sbjct: 167 DFGFGNFYKPGEPLSTCVGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPF 224
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 135 bits (341), Expect = 8e-32 Identities = 78/212 (36%), Positives = 121/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ A KII+ K++ A + + RE +I + L H N+V+ +D+ + + Y++ +L Sbjct: 36 GQEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVT 93 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 94 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAV 152 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ + +++ G+ Y++PEVL + Y D+W+ GVI YILL G P Sbjct: 153 KLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP 212 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 244
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 135 bits (341), Expect = 8e-32 Identities = 78/212 (36%), Positives = 121/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ A KII+ K++ A + + RE +I + L H N+V+ +D+ + + Y++ +L Sbjct: 36 GQEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVT 93 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 94 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAV 152 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ + +++ G+ Y++PEVL + Y D+W+ GVI YILL G P Sbjct: 153 KLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP 212 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 244
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 135 bits (341), Expect = 8e-32 Identities = 78/212 (36%), Positives = 121/212 (57%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ A KII+ K++ A + + RE +I + L H N+V+ +D+ + + Y++ +L Sbjct: 36 GQEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVT 93 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 94 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAV 152 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ + +++ G+ Y++PEVL + Y D+W+ GVI YILL G P Sbjct: 153 KLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP 212 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 244
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 135 bits (340), Expect = 1e-31 Identities = 81/212 (38%), Positives = 119/212 (56%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A KII+ K+T A + + RE +I + L H N+V+ +D+ ++ Y+V +L Sbjct: 37 GFEFAAKIINTKKLT-ARDFQKLEREARICRKLH-HPNIVRLHDSIQEENYHYLVFDLVT 94 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 95 GGELFEDIVAREF-YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAV 153 Query: 378 KLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ ++ D + G+ Y++PEVL + Y DIW+ GVI YILL G P Sbjct: 154 KLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPP 213 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + ++ + + W +V+ EA Sbjct: 214 FWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEA 245
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 135 bits (339), Expect = 1e-31 Identities = 78/197 (39%), Positives = 118/197 (59%), Gaps = 4/197 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KI+ K + + + V+ E+ LK+L H ++ + Y E +++V+E C Sbjct: 34 GEMVAIKIMDKNALGS--DLPRVKTEIDALKSLR-HQHICQLYHVLETKNKIFMVLEYCP 90 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL D I+++ R +EE+ + + QILS VA+ H QG HRDLKPEN LF DEN + Sbjct: 91 GGELFDYIISQD-RLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLF---DENHKL 146 Query: 378 KLIDFGLSDFIR--PDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGS 545 KLIDFGL + D L GS Y APE++ +SY EAD+WS+G++ Y+L+CG Sbjct: 147 KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGF 206 Query: 546 RPFWARTESGIFRSVLR 596 PF +++ ++R Sbjct: 207 LPFDDDNVMALYKKIMR 223
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 135 bits (339), Expect = 1e-31 Identities = 81/186 (43%), Positives = 111/186 (59%), Gaps = 2/186 (1%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K E G VAVKI+++ K+ + + +RRE++ LK L H +++K Y ++++V Sbjct: 36 KHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRHPHIIKLYQVISTPSDIFMV 94 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ME GGEL D I + GR E++++ + QILS V +CH VVHRDLKPEN L D Sbjct: 95 MEYVSGGELFDYI-CKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---D 150 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYILL 536 + K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y LL Sbjct: 151 AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 210 Query: 537 CGSRPF 554 CG+ PF Sbjct: 211 CGTLPF 216
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 135 bits (339), Expect = 1e-31 Identities = 81/186 (43%), Positives = 111/186 (59%), Gaps = 2/186 (1%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K E G VAVKI+++ K+ + + +RRE++ LK L H +++K Y ++++V Sbjct: 36 KHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRHPHIIKLYQVISTPSDIFMV 94 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ME GGEL D I + GR E++++ + QILS V +CH VVHRDLKPEN L D Sbjct: 95 MEYVSGGELFDYI-CKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---D 150 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYILL 536 + K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y LL Sbjct: 151 AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 210 Query: 537 CGSRPF 554 CG+ PF Sbjct: 211 CGTLPF 216
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 135 bits (339), Expect = 1e-31 Identities = 81/186 (43%), Positives = 111/186 (59%), Gaps = 2/186 (1%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K E G VAVKI+++ K+ + + +RRE++ LK L H +++K Y ++++V Sbjct: 34 KHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRHPHIIKLYQVISTPSDIFMV 92 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ME GGEL D I + GR E++++ + QILS V +CH VVHRDLKPEN L D Sbjct: 93 MEYVSGGELFDYI-CKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---D 148 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYILL 536 + K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y LL Sbjct: 149 AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 208 Query: 537 CGSRPF 554 CG+ PF Sbjct: 209 CGTLPF 214
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 135 bits (339), Expect = 1e-31 Identities = 81/186 (43%), Positives = 111/186 (59%), Gaps = 2/186 (1%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K E G VAVKI+++ K+ + + +RRE++ LK L H +++K Y ++++V Sbjct: 34 KHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRHPHIIKLYQVISTPSDIFMV 92 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ME GGEL D I + GR E++++ + QILS V +CH VVHRDLKPEN L D Sbjct: 93 MEYVSGGELFDYI-CKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---D 148 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYILL 536 + K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y LL Sbjct: 149 AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 208 Query: 537 CGSRPF 554 CG+ PF Sbjct: 209 CGTLPF 214
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 134 bits (338), Expect = 2e-31 Identities = 78/212 (36%), Positives = 120/212 (56%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ KII+ K++ A + + RE +I + L H N+V+ +D+ + + Y++ +L Sbjct: 36 GQEYPAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVT 93 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + I+AR Y+E DA + QIL V CH GVVHRDLKPEN L ++ + A + Sbjct: 94 GGELFEDIVARE-YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAV 152 Query: 378 KLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 KL DFGL+ + + +R G+ Y++PEVL + Y D+W+ GVI YILL G P Sbjct: 153 KLADFGLAIEVEGEQQRWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP 212 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 FW + +++ + + W +V+ EA Sbjct: 213 FWDEDQHRLYQQIKARAYDFPSPEWDTVTPEA 244
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 134 bits (338), Expect = 2e-31 Identities = 81/212 (38%), Positives = 119/212 (56%), Gaps = 3/212 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G VA+KI++K+ + ++ ++RE+ I+K + H N+V+ Y+ +YIV+E Sbjct: 34 GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVRLYEVLASPSKIYIVLEFVT 92 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI+ +G R E +++ Q++ VA CH +GV HRDLKPEN L D N + Sbjct: 93 GGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL---DTNGNL 148 Query: 378 KLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSR 548 K+ DFGLS + E L G+ YVAPEVL + Y ADIWS GVI +++L G Sbjct: 149 KVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYL 208 Query: 549 PFWARTESGIFRSVLRADPNLDDSPWPSVSAE 644 PF G++R + A+ PW S + Sbjct: 209 PFSETDLPGLYRKINAAE--FSCPPWFSAEVK 238
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 134 bits (338), Expect = 2e-31 Identities = 76/211 (36%), Positives = 122/211 (57%), Gaps = 2/211 (0%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A+K+I + + E EV +L+ + H+ +++ + E VY+VMEL G Sbjct: 104 QPYAIKMIDRVQ-----GKEVFESEVAVLRRVK-HSYIIQLIEVFETKDKVYMVMELATG 157 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL DRI+A+G +TE DA ++ +L V + H G+ HRDLKPEN L+ ++ + Sbjct: 158 GELFDRIIAKGS-FTERDATRVLNMVLDGVKYLHGLGITHRDLKPENLLYYHPGHDSKIM 216 Query: 381 LIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 + DFGLS + P+ + G+ Y+APE++ R Y + D+W++GVITYILL G+ PF Sbjct: 217 ITDFGLSSTRKGPENFMRTTCGTPEYIAPEIIARKPYMCQVDMWAVGVITYILLSGTMPF 276 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ ++R +L+A + W VSA+A Sbjct: 277 DDENKTRLYRLILKAKYSYAGEHWKDVSAQA 307
>KCC1_METAN (O14408) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| Length = 382 Score = 134 bits (337), Expect = 2e-31 Identities = 83/209 (39%), Positives = 118/209 (56%), Gaps = 2/209 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K + + V E+ +L+ L+ H ++VKF D E YIV +L GGE Sbjct: 47 VAIKIILKKNVKGNEKM--VYAELDMLQRLT-HPHIVKFVDWFESRDKFYIVTQLATGGE 103 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI +G ++TE DA + QI++ V + H VVHRDLKPEN L+ TRD ++ + L Sbjct: 104 LFDRICDQG-KFTEVDASQTIRQIMTAVDYLHDNDVVHRDLKPENLLYVTRDPDSDLVLA 162 Query: 387 DFGLSDFIR-PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWA 560 DFG++ + +E L + GS Y APEV+ + + D+WS+GVITY LLCG PF + Sbjct: 163 DFGITKTLDIKEETLTTMAGSFGYAAPEVMEQKGHGKPVDMWSMGVITYTLLCGYSPFRS 222 Query: 561 RTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + R A + W VS +A Sbjct: 223 ENLRDLLRECTAAPVPFHERYWKDVSQDA 251
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 134 bits (336), Expect = 3e-31 Identities = 68/175 (38%), Positives = 103/175 (58%), Gaps = 3/175 (1%) Frame = +3 Query: 123 HNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCH 302 H N+++ + E A VY+VMEL GGEL DRI+ RG +TE DA ++ +L V + H Sbjct: 150 HTNIIQLMEVFETAERVYMVMELATGGELFDRIITRGS-FTERDATRVLQMVLDGVKYLH 208 Query: 303 LQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDER--LNDIVGSAYYVAPEVLH 476 G+ HRDLKPEN L+ ++ + + DFGL+ + + + G+ Y+APE+L Sbjct: 209 TLGITHRDLKPENLLYYHPGADSKIMITDFGLASTRKKGDECLMKTTCGTPEYIAPEILV 268 Query: 477 RS-YSMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 R Y+ D+W++GVI+YILL G+ PF ++R +L+ + PWPSVS Sbjct: 269 RKPYTNAVDMWALGVISYILLSGTMPFEDDNRMRLYRQILKGKYSFSGEPWPSVS 323
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 134 bits (336), Expect = 3e-31 Identities = 72/185 (38%), Positives = 110/185 (59%), Gaps = 3/185 (1%) Frame = +3 Query: 93 EVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVV 272 E+++L+ + H N+++ + E VY+VMEL GGEL DRI+A+G +TE DA ++ Sbjct: 142 ELRVLRRVR-HANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGS-FTERDATRVLQ 199 Query: 273 QILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRP--DERLNDIVGS 446 +L V + H G+ HRDLKPEN L+ ++ + + DFGL+ + D + G+ Sbjct: 200 MVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGT 259 Query: 447 AYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLRADPNLDDSP 623 Y+APEVL R Y+ D+W++GVI YILL G+ PF + ++R +LR + P Sbjct: 260 PEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEP 319 Query: 624 WPSVS 638 WPSVS Sbjct: 320 WPSVS 324
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 133 bits (335), Expect = 4e-31 Identities = 81/212 (38%), Positives = 122/212 (57%), Gaps = 4/212 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KI+ K T + ++ E++ LK L H ++ + Y E A +++V+E C Sbjct: 34 GEMVAIKIMDKN--TLGSDLPRIKTEIEALKNLR-HQHICQLYHVLETANKIFMVLEYCP 90 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL D I+++ R +EE+ + + QI+S VA+ H QG HRDLKPEN LF DE + Sbjct: 91 GGELFDYIISQD-RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLF---DEYHKL 146 Query: 378 KLIDFGLSDFIR--PDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGS 545 KLIDFGL + D L GS Y APE++ +SY EAD+WS+G++ Y+L+CG Sbjct: 147 KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGF 206 Query: 546 RPFWARTESGIFRSVLRADPNLDDSPWPSVSA 641 PF +++ ++R D W S S+ Sbjct: 207 LPFDDDNVMALYKKIMRG--KYDVPKWLSPSS 236
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 133 bits (335), Expect = 4e-31 Identities = 76/178 (42%), Positives = 108/178 (60%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K ++ ++ ++E + REV+++K L+ H N++K Y E +YIV E + GE Sbjct: 53 VAIKIIDKTRLDSS-NLEKIYREVQLMKLLN-HPNIIKLYQVMETKDMLYIVTEFAKNGE 110 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D L G +E +A+ QILS V +CH +VHRDLK EN L D N +KL Sbjct: 111 MFD-YLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTENLLL---DGNMDIKLA 166 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRPF 554 DFG +F +P E L+ GS Y APEV + Y + DIWS+GV+ Y+L+CGS PF Sbjct: 167 DFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPF 224
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 133 bits (334), Expect = 5e-31 Identities = 83/209 (39%), Positives = 116/209 (55%), Gaps = 2/209 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VAVKII K + + V E+ +L+ L+ H ++V F D E YIV +L GGE Sbjct: 47 VAVKIILKRNVRGNERM--VYDELDLLQKLN-HPHIVHFVDWFESKDKFYIVTQLATGGE 103 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L DRI G++TE+DA + Q+L V + H + +VHRDLKPEN L+ TRD ++ + L Sbjct: 104 LFDRI-CEYGKFTEKDASQTIRQVLDAVNYLHQRNIVHRDLKPENLLYLTRDLDSQLVLA 162 Query: 387 DFGLSDFI-RPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSRPFWA 560 DFG++ + P E L + GS Y APEV L + + DIWS+GVITY LLCG PF + Sbjct: 163 DFGIAKMLDNPAEVLTSMAGSFGYAAPEVMLKQGHGKAVDIWSLGVITYTLLCGYSPFRS 222 Query: 561 RTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + + + W VS +A Sbjct: 223 ENLTDLIEECRSGRVVFHERYWKDVSKDA 251
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 133 bits (334), Expect = 5e-31 Identities = 72/209 (34%), Positives = 121/209 (57%), Gaps = 1/209 (0%) Frame = +3 Query: 24 TVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGG 203 T+ + + ++ + ++ +I++ +S H N++ YD ED V++V+ELC GG Sbjct: 72 TIGFPTMRQVSVSDTLLTNEILVMRRIVENVSPHPNVIDLYDVYEDTNGVHLVLELCSGG 131 Query: 204 ELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKL 383 EL DRI+A+ +Y+E +A +V QI S + H +VHRDLKPEN LF +++P+K+ Sbjct: 132 ELFDRIVAQD-KYSETEAATVVHQIASGLEAVHRANIVHRDLKPENCLFLDVRKDSPLKI 190 Query: 384 IDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFWA 560 +DFGLS + + + GS YV+PE L + + ++D+WS+GVI YILL G PF A Sbjct: 191 MDFGLSSVEEFTDPVVGLFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSGYPPFIA 250 Query: 561 RTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + + ++ + + + W +S A Sbjct: 251 QNNRQKQQMIMNGNFSFYEKTWKGISQPA 279
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 132 bits (333), Expect = 7e-31 Identities = 80/206 (38%), Positives = 118/206 (57%), Gaps = 5/206 (2%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K G + AVKII K+++ ++RE++ LK L H ++V+ ++ + +V Sbjct: 38 KDTVSGHSFAVKIIDKSRIADLNFSLQIKREIRTLKMLK-HPHIVRLHEVLASKTKINMV 96 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 MEL GGEL DRI++ G + TE D + + Q++ +++CH +GV HRDLK EN L D Sbjct: 97 MELVTGGELFDRIVSNG-KLTETDGRKMFQQLIDGISYCHSKGVFHRDLKLENVLL---D 152 Query: 363 ENAPMKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEA-DIWSIGVITY 527 +K+ DFGLS R D L+ GS YVAPEVL +R Y A DIWS GVI Y Sbjct: 153 AKGHIKITDFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLANRGYDGAASDIWSCGVILY 212 Query: 528 ILLCGSRPFWARTESGIFRSVLRADP 605 ++L G PF R + +++ + + DP Sbjct: 213 VILTGCLPFDDRNLAVLYQKICKGDP 238
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 132 bits (332), Expect = 9e-31 Identities = 72/185 (38%), Positives = 110/185 (59%), Gaps = 3/185 (1%) Frame = +3 Query: 93 EVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVV 272 E+++L+ + H N+++ + E VY+VMEL GGEL DRI+A+G +TE DA ++ Sbjct: 142 ELRVLRRVR-HANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGS-FTERDATRVLQ 199 Query: 273 QILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRP--DERLNDIVGS 446 +L V + H G+ HRDLKPEN L+ ++ + + DFGL+ + D + G+ Sbjct: 200 MVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGT 259 Query: 447 AYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLRADPNLDDSP 623 Y+APEVL R Y+ D+W++GVI YILL G+ PF + ++R +LR + P Sbjct: 260 PEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYLGEP 319 Query: 624 WPSVS 638 WPSVS Sbjct: 320 WPSVS 324
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 132 bits (331), Expect = 1e-30 Identities = 76/212 (35%), Positives = 121/212 (57%), Gaps = 5/212 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G A K I K ++ ++ +S E++ REV IL+ + H N++ +D E+ +V +++E Sbjct: 36 GMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIR-HPNIITLHDVFENKTDVVLILE 94 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA TE++A + QIL V + H + + H DLKPEN + + Sbjct: 95 LVSGGELFD-FLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAA 153 Query: 369 AP-MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCG 542 +P +KLIDFG++ I +I G+ +VAPE++ + +EAD+WSIGVITYILL G Sbjct: 154 SPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 213 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 + PF T+ ++ + + D+ + S S Sbjct: 214 ASPFLGETKQETLTNISAVNYDFDEEYFSSTS 245
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 132 bits (331), Expect = 1e-30 Identities = 76/212 (35%), Positives = 121/212 (57%), Gaps = 5/212 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G A K I K ++ ++ +S E++ REV IL+ + H N++ +D E+ +V +++E Sbjct: 36 GMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIR-HPNIITLHDVFENKTDVVLILE 94 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA TE++A + QIL V + H + + H DLKPEN + + Sbjct: 95 LVSGGELFD-FLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAA 153 Query: 369 AP-MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCG 542 +P +KLIDFG++ I +I G+ +VAPE++ + +EAD+WSIGVITYILL G Sbjct: 154 SPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 213 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 + PF T+ ++ + + D+ + S S Sbjct: 214 ASPFLGETKQETLTNISAVNYDFDEEYFSSTS 245
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 132 bits (331), Expect = 1e-30 Identities = 73/215 (33%), Positives = 119/215 (55%), Gaps = 12/215 (5%) Frame = +3 Query: 18 GQTVAVKIIS-KAKMTTAISIEDVR----REVKILKALSGHNNLVKFYDACEDALNVYIV 182 G AVKI+ A+ + +E+VR RE+ IL+ ++GH +++ D+ E + +++V Sbjct: 47 GDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLV 106 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +L GEL D + + +E++ ++I+ +L V F H+ +VHRDLKPEN L D Sbjct: 107 FDLMRKGELFDYLTEKVA-LSEKETRSIMRSLLEAVNFLHVNNIVHRDLKPENILL---D 162 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGVI 521 +N ++L DFG S + P E+L ++ G+ Y+APE+L H Y E D+W+ GVI Sbjct: 163 DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVI 222 Query: 522 TYILLCGSRPFWARTESGIFRSVLRADPNLDDSPW 626 + LL GS PFW R + + R ++ W Sbjct: 223 LFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEW 257
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 132 bits (331), Expect = 1e-30 Identities = 74/220 (33%), Positives = 120/220 (54%), Gaps = 12/220 (5%) Frame = +3 Query: 18 GQTVAVKIIS-KAKMTTAISIEDVR----REVKILKALSGHNNLVKFYDACEDALNVYIV 182 G AVKI+ A+ + +E+VR RE IL+ ++GH +++ D+ E + +++V Sbjct: 47 GHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLV 106 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +L GEL D + + +E++ ++I+ +L V+F H +VHRDLKPEN L D Sbjct: 107 FDLMRKGELFDYLTEKVA-LSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILL---D 162 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGVI 521 +N ++L DFG S + P E+L ++ G+ Y+APE+L H Y E D+W+ GVI Sbjct: 163 DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVI 222 Query: 522 TYILLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSA 641 + LL GS PFW R + + R ++ W S+ Sbjct: 223 LFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSS 262
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 131 bits (330), Expect = 2e-30 Identities = 77/214 (35%), Positives = 124/214 (57%), Gaps = 7/214 (3%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G+ A K I K +++++ +S E++ REV IL+ + H N++ +D E+ +V +++E Sbjct: 36 GKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR-HPNIITLHDIFENKTDVVLILE 94 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA TE++A + QIL V + H + + H DLKPEN + D+N Sbjct: 95 LVSGGELFD-FLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL--DKN 151 Query: 369 AP---MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILL 536 P +KLIDFG++ I +I G+ +VAPE++ + +EAD+WSIGVITYILL Sbjct: 152 VPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL 211 Query: 537 CGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 G+ PF T+ ++ + + D+ + + S Sbjct: 212 SGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 131 bits (330), Expect = 2e-30 Identities = 79/195 (40%), Positives = 118/195 (60%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVKII K ++ ++ S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 76 GKEVAVKIIDKTQLNSS-SLQKLFREVRIMKVLN-HPNIVKLFEVIETEKTLYLVMEYAS 133 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 134 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLL---DADMNI 189 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 190 KIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 249 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 250 FDGQNLKELRERVLR 264
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 131 bits (330), Expect = 2e-30 Identities = 81/187 (43%), Positives = 111/187 (59%), Gaps = 4/187 (2%) Frame = +3 Query: 6 GEYK--GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYI 179 GE++ G VAVKI+++ K+ + + ++RE++ LK L H +++K Y + ++ Sbjct: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRHPHIIKLYQVISTPTDFFM 91 Query: 180 VMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR 359 VME GGEL D I + GR E +A+ + QILS V +CH VVHRDLKPEN L Sbjct: 92 VMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL--- 147 Query: 360 DENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYIL 533 D + K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y L Sbjct: 148 DAHMNAKIADFGLSNIMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207 Query: 534 LCGSRPF 554 LCG+ PF Sbjct: 208 LCGTLPF 214
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 131 bits (330), Expect = 2e-30 Identities = 81/187 (43%), Positives = 111/187 (59%), Gaps = 4/187 (2%) Frame = +3 Query: 6 GEYK--GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYI 179 GE++ G VAVKI+++ K+ + + ++RE++ LK L H +++K Y + ++ Sbjct: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRHPHIIKLYQVISTPTDFFM 91 Query: 180 VMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR 359 VME GGEL D I + GR E +A+ + QILS V +CH VVHRDLKPEN L Sbjct: 92 VMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL--- 147 Query: 360 DENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYIL 533 D + K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y L Sbjct: 148 DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207 Query: 534 LCGSRPF 554 LCG+ PF Sbjct: 208 LCGTLPF 214
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 131 bits (330), Expect = 2e-30 Identities = 79/195 (40%), Positives = 118/195 (60%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVKII K ++ ++ S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 76 GKEVAVKIIDKTQLNSS-SLQKLFREVRIMKVLN-HPNIVKLFEVIETEKTLYLVMEYAS 133 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 134 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLL---DADMNI 189 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 190 KIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 249 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 250 FDGQNLKELRERVLR 264
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 131 bits (329), Expect = 2e-30 Identities = 81/187 (43%), Positives = 110/187 (58%), Gaps = 4/187 (2%) Frame = +3 Query: 6 GEYK--GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYI 179 GE++ G VAVKI+++ K+ + + ++RE++ LK L H +++K Y + ++ Sbjct: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRHPHIIKLYQVISTPTDFFM 91 Query: 180 VMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR 359 VME GGEL D I + GR E +A+ + QILS V +CH VVHRDLKPEN L Sbjct: 92 VMEYVSGGELFDYI-CKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL--- 147 Query: 360 DENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYIL 533 D K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y L Sbjct: 148 DAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207 Query: 534 LCGSRPF 554 LCG+ PF Sbjct: 208 LCGTLPF 214
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 131 bits (329), Expect = 2e-30 Identities = 81/187 (43%), Positives = 110/187 (58%), Gaps = 4/187 (2%) Frame = +3 Query: 6 GEYK--GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYI 179 GE++ G VAVKI+++ K+ + + ++RE++ LK L H +++K Y + ++ Sbjct: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRHPHIIKLYQVISTPTDFFM 91 Query: 180 VMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR 359 VME GGEL D I + GR E +A+ + QILS V +CH VVHRDLKPEN L Sbjct: 92 VMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL--- 147 Query: 360 DENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-MEADIWSIGVITYIL 533 D K+ DFGLS+ + E L GS Y APEV+ R Y+ E DIWS GVI Y L Sbjct: 148 DAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207 Query: 534 LCGSRPF 554 LCG+ PF Sbjct: 208 LCGTLPF 214
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 131 bits (329), Expect = 2e-30 Identities = 75/203 (36%), Positives = 121/203 (59%), Gaps = 1/203 (0%) Frame = +3 Query: 42 ISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRI 221 +S A +T I + +RR I++ +S H N++ YD ED V++V+ELC GGEL DRI Sbjct: 91 VSDALLTNEILV--MRR---IVENVSPHPNVIDLYDVYEDTNGVHLVLELCSGGELFDRI 145 Query: 222 LARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLS 401 +A+ +Y+E +A +V QI++ + H ++HRDLKPEN LF +++ +K++DFGLS Sbjct: 146 VAQD-KYSETEASTVVHQIVAGLEAIHRANIIHRDLKPENCLFLDVGKDSSLKIMDFGLS 204 Query: 402 DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFWARTESGI 578 + + + GS YV+PE L + + ++D+WS+GVI YILL G PF A+ Sbjct: 205 SVEEFTDPVVGLFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSGYPPFIAQNNRQK 264 Query: 579 FRSVLRADPNLDDSPWPSVSAEA 647 + +L + + + W +S A Sbjct: 265 QQMILNGNFSFYEKTWKGISQSA 287
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 130 bits (328), Expect = 3e-30 Identities = 79/195 (40%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVKII K ++ S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 83 GREVAVKIIDKTQLNPT-SLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLVMEYAS 140 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 141 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLL---DADMNI 196 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 197 KIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 256 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 257 FDGQNLKELRERVLR 271
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 130 bits (328), Expect = 3e-30 Identities = 79/195 (40%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVKII K ++ S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 83 GREVAVKIIDKTQLNPT-SLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLVMEYAS 140 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 141 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLL---DADMNI 196 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 197 KIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 256 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 257 FDGQNLKELRERVLR 271
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 130 bits (327), Expect = 3e-30 Identities = 77/195 (39%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K ++ S++ + REV+I+K L+ H N+VK ++ E +Y++ME Sbjct: 79 GREVAIKIIDKTQLNPT-SLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYAS 136 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 137 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLL---DADMNI 192 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 193 KIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 252 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 253 FDGQNLKELRERVLR 267
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 130 bits (327), Expect = 3e-30 Identities = 79/195 (40%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVKII K ++ S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 83 GREVAVKIIDKTQLNPT-SLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLVMEYAS 140 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 141 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLL---DGDMNI 196 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 197 KIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 256 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 257 FDGQNLKELRERVLR 271
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 130 bits (327), Expect = 3e-30 Identities = 77/195 (39%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K ++ S++ + REV+I+K L+ H N+VK ++ E +Y++ME Sbjct: 79 GREVAIKIIDKTQLNPT-SLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYAS 136 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+S V +CH + +VHRDLK EN L D + + Sbjct: 137 GGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLL---DADMNI 192 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E D+WS+GVI Y L+ GS P Sbjct: 193 KITDFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 252 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 253 FDGQNLKELRERVLR 267
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 130 bits (326), Expect = 4e-30 Identities = 79/220 (35%), Positives = 115/220 (52%), Gaps = 14/220 (6%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVR-------REVKILKALSGHNNLVKFYDACEDALNVYI 179 Q AVK+I + S E+VR +EV IL+ +SGH N+++ D E ++ Sbjct: 43 QEYAVKVIDVTG-GGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFL 101 Query: 180 VMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR 359 V +L + GEL D L +E++ + I+ +L V+ H +VHRDLKPEN L Sbjct: 102 VFDLMKRGELFD-YLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILL--- 157 Query: 360 DENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGV 518 D+N +KL DFG S + P ERL ++ G+ Y+APE++ H Y E D+WS GV Sbjct: 158 DDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGV 217 Query: 519 ITYILLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 I Y LL GS PFW R + + R ++ + W S Sbjct: 218 IMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYS 257
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 130 bits (326), Expect = 4e-30 Identities = 75/178 (42%), Positives = 107/178 (60%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K+++ A+++E + REV+I+K L H +++K Y E +Y+V E + GE Sbjct: 46 VAIKIIDKSQLD-AVNLEKIYREVQIMKMLD-HPHIIKLYQVMETKSMLYLVTEYAKNGE 103 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D LA GR E +A+ QILS V +CH + VVHRDLK EN L D N +K+ Sbjct: 104 IFD-YLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLKAENLLL---DNNMNIKIA 159 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSMEADIWSIGVITYILLCGSRPF 554 DFG +F + E L GS Y APEV + + DIWS+GV+ Y+L+CG+ PF Sbjct: 160 DFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPF 217
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 130 bits (326), Expect = 4e-30 Identities = 81/215 (37%), Positives = 121/215 (56%), Gaps = 5/215 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G A K I K + ++ +S ED+ REV ILK + H N++ ++ E+ +V +++E Sbjct: 36 GLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ-HPNVITLHEVYENKTDVILILE 94 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA TEE+A + QIL+ V + H + H DLKPEN + R+ Sbjct: 95 LVAGGELFD-FLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVP 153 Query: 369 AP-MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCG 542 P +K+IDFGL+ I +I G+ +VAPE++ + +EAD+WSIGVITYILL G Sbjct: 154 KPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 213 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + PF T+ +V + +D + + SA A Sbjct: 214 ASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 129 bits (325), Expect = 6e-30 Identities = 74/178 (41%), Positives = 107/178 (60%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K+++ A+++E + REV+I+K L H +++K Y E +Y+V E + GE Sbjct: 46 VAIKIIDKSQLD-AVNLEKIYREVQIMKMLD-HPHIIKLYQVMETKSMLYLVTEYAKNGE 103 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D LA GR E +A+ QILS V +CH + +VHRDLK EN L D N +K+ Sbjct: 104 IFD-YLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLL---DNNMNIKIA 159 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSMEADIWSIGVITYILLCGSRPF 554 DFG +F + E L GS Y APEV + + DIWS+GV+ Y+L+CG+ PF Sbjct: 160 DFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPF 217
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 129 bits (325), Expect = 6e-30 Identities = 70/177 (39%), Positives = 108/177 (61%), Gaps = 1/177 (0%) Frame = +3 Query: 99 KILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQI 278 KI++ +S H N++ YD ED V++V+ELC GGEL DRI+ + RY+E A A+V QI Sbjct: 99 KIVENVSPHPNVIDLYDVYEDENGVHLVLELCSGGELFDRIVKQE-RYSEVGAAAVVRQI 157 Query: 279 LSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYV 458 +A H +VHRDLKPEN LF ++P+K++DFGLS + + + GS YV Sbjct: 158 AQGLAALHRSNIVHRDLKPENCLFLDNTVDSPLKIMDFGLSSVEEFTDPVVGLFGSIDYV 217 Query: 459 APEVLHR-SYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLRADPNLDDSPW 626 +PE L + + ++D+W++GVI YILL G PF A++ + ++ + + + W Sbjct: 218 SPEALSQGQVTSKSDMWALGVILYILLSGYPPFIAQSNRQKQQMIMAGEFSFYEKTW 274
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 129 bits (325), Expect = 6e-30 Identities = 73/219 (33%), Positives = 119/219 (54%), Gaps = 12/219 (5%) Frame = +3 Query: 18 GQTVAVKIIS-KAKMTTAISIEDVR----REVKILKALSGHNNLVKFYDACEDALNVYIV 182 G AVKI+ A+ + +E+VR RE+ IL+ ++GH +++ D+ E + +++V Sbjct: 47 GDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLV 106 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +L GEL D + + +E++ ++I+ +L V+F H +VHRDLKPEN L D Sbjct: 107 FDLMRKGELFDYLTEKVA-LSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILL---D 162 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGVI 521 +N ++L DFG S + E+L ++ G+ Y+APE+L H Y E D+W+ GVI Sbjct: 163 DNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVI 222 Query: 522 TYILLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 + LL GS PFW R + + R ++ W S Sbjct: 223 LFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDCS 261
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 129 bits (325), Expect = 6e-30 Identities = 78/195 (40%), Positives = 115/195 (58%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K ++ + S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 82 GREVAIKIIDKTQLNPS-SLQKLFREVRIMKGLN-HPNIVKLFEVIETEKTLYLVMEYAS 139 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GE+ D +++ G R E++A+A QI+S V +CH + +VHRDLK EN L D A + Sbjct: 140 AGEVFDYLVSHG-RMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLL---DAEANI 195 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E DIWS+GVI Y L+ GS P Sbjct: 196 KIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLP 255 Query: 552 FWARTESGIFRSVLR 596 F + VLR Sbjct: 256 FDGHNLKELRERVLR 270
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 129 bits (325), Expect = 6e-30 Identities = 78/195 (40%), Positives = 115/195 (58%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K ++ + S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 82 GREVAIKIIDKTQLNPS-SLQKLFREVRIMKGLN-HPNIVKLFEVIETEKTLYLVMEYAS 139 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GE+ D +++ G R E++A+A QI+S V +CH + +VHRDLK EN L D A + Sbjct: 140 AGEVFDYLVSHG-RMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLL---DAEANI 195 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + Y E DIWS+GVI Y L+ GS P Sbjct: 196 KIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLP 255 Query: 552 FWARTESGIFRSVLR 596 F + VLR Sbjct: 256 FDGHNLKELRERVLR 270
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 129 bits (324), Expect = 7e-30 Identities = 78/219 (35%), Positives = 117/219 (53%), Gaps = 13/219 (5%) Frame = +3 Query: 21 QTVAVKII--SKAKMTTAISIEDVR----REVKILKALSGHNNLVKFYDACEDALNVYIV 182 Q AVKII + ++ ++++R +EV IL+ +SGH N+++ D E ++V Sbjct: 43 QEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFLV 102 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +L + GEL D L TE++ + I+ +L VV H +VHRDLKPEN L D Sbjct: 103 FDLMKRGELFD-YLTEKVTLTEKETRKIMRALLEVVCTLHKLNIVHRDLKPENILL---D 158 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGVI 521 +N +KL DFG S ++P E+L ++ G+ Y+APE++ H Y E D+WS GVI Sbjct: 159 DNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDEGHPGYGKEVDMWSTGVI 218 Query: 522 TYILLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 Y LL GS PFW R + + R ++ W S Sbjct: 219 MYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYS 257
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 129 bits (323), Expect = 1e-29 Identities = 77/219 (35%), Positives = 117/219 (53%), Gaps = 13/219 (5%) Frame = +3 Query: 21 QTVAVKII--SKAKMTTAISIEDVR----REVKILKALSGHNNLVKFYDACEDALNVYIV 182 Q AVKII + ++ ++++R +EV IL+ +SGH N+++ D E ++V Sbjct: 43 QEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFLV 102 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +L + GEL D L TE++ + I+ +L V+ H +VHRDLKPEN L D Sbjct: 103 FDLMKRGELFD-YLTEKVTLTEKETRKIMRALLEVICTLHKLNIVHRDLKPENILL---D 158 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGVI 521 +N +KL DFG S ++P E+L ++ G+ Y+APE++ H Y E D+WS GVI Sbjct: 159 DNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDDGHPGYGKEVDMWSTGVI 218 Query: 522 TYILLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 Y LL GS PFW R + + R ++ W S Sbjct: 219 MYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYS 257
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 129 bits (323), Expect = 1e-29 Identities = 73/192 (38%), Positives = 108/192 (56%), Gaps = 4/192 (2%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSG--HNNLVKFYDACEDALNVYIVMELCEG 200 VA+K++++ +M E +RE+KIL+ H ++++ Y+ ++++VME C+ Sbjct: 40 VAIKVLNRRQMRAPEMEEKAKREIKILRLFIDLIHPHIIRVYEVIVTPKDIFVVMEYCQN 99 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G+LLD IL + R E++A+ QI+S V +CH VVHRDLKPEN L D +K Sbjct: 100 GDLLDYILEKR-RLQEDEARRTFQQIISAVEYCHRNKVVHRDLKPENLLL---DSKYNVK 155 Query: 381 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRPF 554 L DFGLS+ + L GS Y APEV+ E D+WS GVI Y LLCG+ PF Sbjct: 156 LADFGLSNVMHDGHFLKTSCGSLNYAAPEVISGKLYAGPEIDVWSCGVILYALLCGAVPF 215 Query: 555 WARTESGIFRSV 590 +F+ + Sbjct: 216 DDDNIPNLFKKI 227
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 128 bits (322), Expect = 1e-29 Identities = 75/178 (42%), Positives = 105/178 (58%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K ++ + ++E + REV+I+K L+ H +++K Y E +YIV E + GE Sbjct: 52 VAIKIIDKTRLDPS-NLEKIYREVQIMKLLN-HPHIIKLYQVMETKDMLYIVTEFAKNGE 109 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D L G +E +A+ QILS V +CH +VHRDLK EN L D N +KL Sbjct: 110 MFDH-LTSNGHLSESEARKKFWQILSAVEYCHSHHIVHRDLKTENLLL---DANMNIKLA 165 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRPF 554 DFG +F + E L+ GS Y APEV + Y DIWS+GV+ Y+L+CGS PF Sbjct: 166 DFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLDIWSLGVVLYVLVCGSLPF 223
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 128 bits (321), Expect = 2e-29 Identities = 71/189 (37%), Positives = 113/189 (59%), Gaps = 2/189 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G+ VAVK+I K K+ T ++ + +EV+ +K + H N+V+ Y+ + +Y+++EL Sbjct: 37 FTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQ-HPNIVRLYEVIDTQTKLYLILEL 94 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 +GG++ D I+ E+ AK QI+ +++CH VVHRDLKPEN +F ++ Sbjct: 95 GDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFF--EKQG 152 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEA-DIWSIGVITYILLCGS 545 +KL DFG S+ +P ++L GS Y APE+ L Y A DIWS+GVI ++L+CG Sbjct: 153 LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQ 212 Query: 546 RPFWARTES 572 PF +S Sbjct: 213 PPFQEANDS 221
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 128 bits (321), Expect = 2e-29 Identities = 74/178 (41%), Positives = 107/178 (60%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K ++ ++ ++E + REV+++K L+ H +++K Y E +YIV E + GE Sbjct: 53 VAIKIIDKTRLDSS-NLEKIYREVQLMKLLN-HPHIIKLYQVMETKDMLYIVTEFAKNGE 110 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D L G +E +A+ QILS V +CH +VHRDLK EN L D N +KL Sbjct: 111 MFD-YLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLL---DGNMDIKLA 166 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGSRPF 554 DFG +F + E L+ GS Y APEV + Y + DIWS+GV+ Y+L+CGS PF Sbjct: 167 DFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPF 224
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 128 bits (321), Expect = 2e-29 Identities = 77/207 (37%), Positives = 119/207 (57%), Gaps = 7/207 (3%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G A K I K + + +S E++ REV IL+ + H+N++ +D E+ +V +++E Sbjct: 46 GLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL-HHNVITLHDVYENRTDVVLILE 104 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA+ +EE+A + + QIL V + H + + H DLKPEN + D+N Sbjct: 105 LVSGGELFD-FLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL--DKN 161 Query: 369 APM---KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILL 536 P+ KLIDFGL+ I +I G+ +VAPE++ + +EAD+WSIGVITYILL Sbjct: 162 IPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL 221 Query: 537 CGSRPFWARTESGIFRSVLRADPNLDD 617 G+ PF T+ ++ + D+ Sbjct: 222 SGASPFLGDTKQETLANITAVSYDFDE 248
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 128 bits (321), Expect = 2e-29 Identities = 71/189 (37%), Positives = 113/189 (59%), Gaps = 2/189 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G+ VAVK+I K K+ T ++ + +EV+ +K + H N+V+ Y+ + +Y+++EL Sbjct: 37 FTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQ-HPNIVRLYEVIDTQTKLYLILEL 94 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 +GG++ D I+ E+ AK QI+ +++CH VVHRDLKPEN +F ++ Sbjct: 95 GDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFF--EKQG 152 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEA-DIWSIGVITYILLCGS 545 +KL DFG S+ +P ++L GS Y APE+ L Y A DIWS+GVI ++L+CG Sbjct: 153 LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQ 212 Query: 546 RPFWARTES 572 PF +S Sbjct: 213 PPFQEANDS 221
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 128 bits (321), Expect = 2e-29 Identities = 71/189 (37%), Positives = 113/189 (59%), Gaps = 2/189 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G+ VAVK+I K K+ T ++ + +EV+ +K + H N+V+ Y+ + +Y+++EL Sbjct: 37 FTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQ-HPNIVRLYEVIDTQTKLYLILEL 94 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 +GG++ D I+ E+ AK QI+ +++CH VVHRDLKPEN +F ++ Sbjct: 95 GDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFF--EKQG 152 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEA-DIWSIGVITYILLCGS 545 +KL DFG S+ +P ++L GS Y APE+ L Y A DIWS+GVI ++L+CG Sbjct: 153 LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQ 212 Query: 546 RPFWARTES 572 PF +S Sbjct: 213 PPFQEANDS 221
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 127 bits (320), Expect = 2e-29 Identities = 77/195 (39%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVKII K ++ ++ S++ + REV+I+K L+ H N+VK ++ E +Y+VME Sbjct: 76 GKEVAVKIIDKTQLNSS-SLQKLFREVRIMKVLN-HPNIVKLFEVIETEKTLYLVMEYAS 133 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGE+ D ++A G R E++A+A QI+ V +CH + +VHRDLK EN L D + + Sbjct: 134 GGEVFDYLVAHG-RMKEKEARAKFRQIVLHVQYCHQKFIVHRDLKAENLLL---DADMNI 189 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH--RSYSMEADIWSIGVITYILLCGSRP 551 K+ DFG S+ +L+ GS Y APE+ + E D+WS+GVI Y L+ GS P Sbjct: 190 KIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKIDGPEVDVWSLGVILYTLVSGSLP 249 Query: 552 FWARTESGIFRSVLR 596 F + + VLR Sbjct: 250 FDGQNLKELRERVLR 264
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 127 bits (320), Expect = 2e-29 Identities = 81/221 (36%), Positives = 117/221 (52%), Gaps = 11/221 (4%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ AVKI+S+ E+ +REV L+ H N+V ++ D L+ Y+V+EL Sbjct: 434 GQEFAVKILSRRLE------ENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLR 487 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQ-GVVHRDLKPENFLFTTRDENAP 374 GGELL+ I + ++E +A I+ ++S V+F H + GVVHRDLKPEN L+ AP Sbjct: 488 GGELLEHI-RKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP 546 Query: 375 MKLIDFGLSDF--IRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGS 545 +K+IDFG + P E + + Y APE+L + Y D+WS+GVI Y++L G Sbjct: 547 VKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQ 606 Query: 546 RPFWARTESG-------IFRSVLRADPNLDDSPWPSVSAEA 647 PF + G I + +LD W VS EA Sbjct: 607 VPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 647 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/209 (27%), Positives = 104/209 (49%), Gaps = 9/209 (4%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTT-AISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 G G+ A+K++ KA + A + E R E +L+ + LV + A + ++++ Sbjct: 55 GHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLI 114 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGE+ + R + E + + +I+ + H G+++RDLK EN L D Sbjct: 115 LDYVSGGEMFTHLYQRQ-YFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLL---D 170 Query: 363 ENAPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYI 530 + L DFGLS +F+ + ER G+ Y+APE++ + D WS+G++ + Sbjct: 171 SEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLGILLFE 230 Query: 531 LLCGSRPFW----ARTESGIFRSVLRADP 605 LL G+ PF T++ + R +L+ P Sbjct: 231 LLTGASPFTLEGERNTQAEVSRRILKCSP 259
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 127 bits (319), Expect = 3e-29 Identities = 83/219 (37%), Positives = 116/219 (52%), Gaps = 10/219 (4%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIE-----DVRREVKILKALSGHNNLVKFYDACEDALNVYIVM 185 Q VA+KIISK + S E V E++ILK L+ H ++K D DA + YIV+ Sbjct: 248 QKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLN-HPCIIKIKDVF-DAEDYYIVL 305 Query: 186 ELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDE 365 EL EGGEL DR++ R E K Q+L V + H G++HRDLKPEN L ++++E Sbjct: 306 ELMEGGELFDRVVGNK-RLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEE 364 Query: 366 NAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL----HRSYSMEADIWSIGVITYIL 533 + +K+ DFG S + + + G+ Y+APEVL YS D WS+GVI +I Sbjct: 365 DCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFIC 424 Query: 534 LCGSRPFWA-RTESGIFRSVLRADPNLDDSPWPSVSAEA 647 L G PF +T+ + + N W VS EA Sbjct: 425 LSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEA 463
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 127 bits (319), Expect = 3e-29 Identities = 80/215 (37%), Positives = 121/215 (56%), Gaps = 5/215 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G A K I K + ++ +S ED+ REV ILK + H N++ ++ E+ +V +++E Sbjct: 36 GLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIR-HPNVITLHEVYENKTDVILILE 94 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA TEE+A + QILS V + H + H DLKPEN + R+ Sbjct: 95 LVAGGELFD-FLAEKESLTEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVP 153 Query: 369 AP-MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCG 542 P +K+IDFGL+ I +I G+ +VAPE++ + +EAD+WSIGVITYILL G Sbjct: 154 KPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 213 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + PF T+ +V + + ++ + + S A Sbjct: 214 ASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLA 248
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 127 bits (318), Expect = 4e-29 Identities = 73/200 (36%), Positives = 115/200 (57%), Gaps = 5/200 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G +VA+K+I K ++ E ++RE+ ++ L H N+V+ ++ +Y VME + Sbjct: 35 GDSVAIKVIDKERILKVGMTEQIKREISAMRLLR-HPNIVELHEVMATKSKIYFVMEHVK 93 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL +++ G+ E+ A+ Q++ V FCH +GV HRDLKPEN L DE+ + Sbjct: 94 GGELFNKVST--GKLREDVARKYFQQLVRAVDFCHSRGVCHRDLKPENLLL---DEHGNL 148 Query: 378 KLIDFG---LSDFIRPDERLNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYILLCG 542 K+ DFG LSD R D L+ G+ YVAPEV+ R+ +AD+WS GVI ++LL G Sbjct: 149 KISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRNGYDGFKADVWSCGVILFVLLAG 208 Query: 543 SRPFWARTESGIFRSVLRAD 602 PF +++ + +A+ Sbjct: 209 YLPFRDSNLMELYKKIGKAE 228
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 127 bits (318), Expect = 4e-29 Identities = 70/185 (37%), Positives = 108/185 (58%), Gaps = 3/185 (1%) Frame = +3 Query: 93 EVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVV 272 E+ +L+ +S H +V+ + E VY+VMEL GGEL DR++A+G +TE DA I+ Sbjct: 108 ELSVLRRVS-HRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGS-FTERDAVRILQ 165 Query: 273 QILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGL--SDFIRPDERLNDIVGS 446 + + + H + HR+LKPEN L+ E + + + DFGL S D + + G+ Sbjct: 166 MVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGT 225 Query: 447 AYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLRADPNLDDSP 623 Y+APEVL R Y+ D+W++GVITY LL G PF +++ ++R +L+ N P Sbjct: 226 PEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEP 285 Query: 624 WPSVS 638 WPS+S Sbjct: 286 WPSIS 290
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 126 bits (317), Expect = 5e-29 Identities = 73/178 (41%), Positives = 106/178 (59%), Gaps = 2/178 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+KII K+++ A+++E + REV+I+K L H +++K Y E +Y+V E + GE Sbjct: 46 VAIKIIDKSQLD-AVNLEKIYREVQIMKMLD-HPHIIKLYQVMETKSMLYLVTEYAKNGE 103 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + D LA GR E +A+ QILS V +CH + +VHRDLK EN L D N +K+ Sbjct: 104 IFD-YLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLL---DNNMNIKIA 159 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSMEADIWSIGVITYILLCGSRPF 554 DF +F + E L GS Y APEV + + DIWS+GV+ Y+L+CG+ PF Sbjct: 160 DFSFGNFFKSGELLATWRGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPF 217
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 126 bits (317), Expect = 5e-29 Identities = 71/195 (36%), Positives = 112/195 (57%), Gaps = 2/195 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G+ VA+K I K K+ + + +RRE++I+ +L+ H +++ Y+ E+ + I+ME Sbjct: 77 FSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLN-HPHIISIYEVFENKDKIVIIMEY 135 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 GEL D I R R +E + + QI+S V +CH GVVHRDLK EN L D+N Sbjct: 136 ASKGELYDYISERR-RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL---DDNC 191 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGS 545 +K+ DFGLS+ + D+ L GS Y +PE+++ R Y E D W++GV+ Y L+ G+ Sbjct: 192 NIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGT 251 Query: 546 RPFWARTESGIFRSV 590 PF + R + Sbjct: 252 MPFDGFDHKNLIRQI 266
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 126 bits (316), Expect = 6e-29 Identities = 75/189 (39%), Positives = 110/189 (58%), Gaps = 5/189 (2%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K + VA+KI+ K K+ +E +RRE+ +K + H N+V+ ++ ++IV Sbjct: 38 KNTENDEPVAIKILDKEKVQKHRLVEQIRREICTMKLVK-HPNVVRLFEVMGSKARIFIV 96 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +E GGEL + I+A GR EE+A+ Q+++ V +CH +GV HRDLK EN L D Sbjct: 97 LEYVTGGELFE-IIATNGRLKEEEARKYFQQLINAVDYCHSRGVYHRDLKLENLLL---D 152 Query: 363 ENAPMKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITY 527 + +K+ DFGLS + ++ D L+ G+ YVAPEV+ R Y ADIWS GVI Y Sbjct: 153 ASGNLKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDRGYDGAAADIWSCGVILY 212 Query: 528 ILLCGSRPF 554 +LL G PF Sbjct: 213 VLLAGFLPF 221
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 125 bits (315), Expect = 8e-29 Identities = 74/212 (34%), Positives = 123/212 (58%), Gaps = 9/212 (4%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+K ++K K ++ +++ + REV ILK++ H +++ E +Y+VMELCE GEL Sbjct: 143 AIKKVNKEKAGSS-AVKLLEREVNILKSVK-HEHIIHLEQVFETPKKMYLVMELCEDGEL 200 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTT------RDENA 371 + IL R G ++E + + I+ + S +A+ H +VHRDLK EN + + + N Sbjct: 201 KE-ILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINL 259 Query: 372 PMKLIDFGLS--DFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCG 542 +K+ DFGL+ R + L G+ Y+APEV+ YS + DIWSIGV+ Y+LL G Sbjct: 260 NIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRG 319 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 PF A +E +F + + + + +++ W S+S Sbjct: 320 EPPFLASSEEKLFELIRKGELHFENAVWNSIS 351
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 125 bits (315), Expect = 8e-29 Identities = 75/216 (34%), Positives = 116/216 (53%), Gaps = 13/216 (6%) Frame = +3 Query: 30 AVKII--SKAKMTTAISIEDVR----REVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 AVKII + +A ++++R +EV IL+ +SGH N+++ D E ++V +L Sbjct: 46 AVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDL 105 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 + GEL D L +E++ + I+ +L V+ H +VHRDLKPEN L D++ Sbjct: 106 MKKGELFD-YLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILL---DDDM 161 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSMEADIWSIGVITYI 530 +KL DFG S + P E+L ++ G+ Y+APE++ H Y E D+WS GVI Y Sbjct: 162 NIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYT 221 Query: 531 LLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVS 638 LL GS PFW R + + R ++ + W S Sbjct: 222 LLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYS 257
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 125 bits (315), Expect = 8e-29 Identities = 74/195 (37%), Positives = 113/195 (57%), Gaps = 4/195 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K ++KA + + + + + E++I K++S H N+V+F D ED NVYI++E+C Sbjct: 104 GEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMS-HPNIVQFIDCFEDDSNVYILLEICP 162 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 G L++ +L R TE + + QI + + H + V+HRDLK N F D N + Sbjct: 163 NGSLME-LLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFF---DSNYNL 218 Query: 378 KLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVL---HRSYSMEADIWSIGVITYILLCGS 545 K+ DFGL+ + + ER I G+ Y+APEVL H +S E DIWS+GV+ Y LL G Sbjct: 219 KIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGK 278 Query: 546 RPFWARTESGIFRSV 590 PF AR + I+ + Sbjct: 279 PPFQARDVNTIYERI 293
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 125 bits (314), Expect = 1e-28 Identities = 76/211 (36%), Positives = 118/211 (55%), Gaps = 2/211 (0%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A KII+ K++ A + + RE +I + L H N+V+ +D+ + Y+V +L G Sbjct: 38 QEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTG 95 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL + I+AR Y+E DA + QIL V H +VHRDLKPEN L ++ + A +K Sbjct: 96 GELFEDIVARE-YYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK 154 Query: 381 LIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 L DFGL+ ++ +++ G+ Y++PEVL + Y DIW+ GVI YILL G PF Sbjct: 155 LADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPF 214 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 W + +++ + + W +V+ EA Sbjct: 215 WDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 245
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 125 bits (314), Expect = 1e-28 Identities = 73/190 (38%), Positives = 108/190 (56%), Gaps = 2/190 (1%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VAVKI+++ K+ + + +RRE++ L +L H ++++ Y +++++ME GGE Sbjct: 113 VAVKILNRQKIKSLDVVGKIRREIQNL-SLFRHPHIIRLYQVISTPSDIFMIMEHVSGGE 171 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L D I+ + GR +A+ QI+S V +CH VVHRDLKPEN L DE +K+ Sbjct: 172 LFDYIV-KHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLL---DEQNNVKIA 227 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRPFWA 560 DFGLS+ + + L GS Y APEV+ E D+WS GVI Y LLCG+ PF Sbjct: 228 DFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDD 287 Query: 561 RTESGIFRSV 590 +FR + Sbjct: 288 EHVPSLFRKI 297
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 125 bits (314), Expect = 1e-28 Identities = 76/207 (36%), Positives = 117/207 (56%), Gaps = 7/207 (3%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA---ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 G A K I K + + + E++ REV IL+ + H N++ +D E+ +V +++E Sbjct: 46 GLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL-HPNIITLHDVYENRTDVVLILE 104 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 L GGEL D LA+ +EE+A + + QIL V + H + + H DLKPEN + D+N Sbjct: 105 LVSGGELFD-FLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL--DKN 161 Query: 369 APM---KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILL 536 P+ KLIDFGL+ I +I G+ +VAPE++ + +EAD+WSIGVITYILL Sbjct: 162 IPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL 221 Query: 537 CGSRPFWARTESGIFRSVLRADPNLDD 617 G+ PF T+ ++ + D+ Sbjct: 222 SGASPFLGDTKQETLANITAVSYDFDE 248
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 125 bits (314), Expect = 1e-28 Identities = 76/211 (36%), Positives = 118/211 (55%), Gaps = 2/211 (0%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A KII+ K++ A + + RE +I + L H N+V+ +D+ + Y+V +L G Sbjct: 38 QEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTG 95 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL + I+AR Y+E DA + QIL V H +VHRDLKPEN L ++ + A +K Sbjct: 96 GELFEDIVARE-YYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK 154 Query: 381 LIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 L DFGL+ ++ +++ G+ Y++PEVL + Y DIW+ GVI YILL G PF Sbjct: 155 LADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPF 214 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 W + +++ + + W +V+ EA Sbjct: 215 WDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 245
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 125 bits (314), Expect = 1e-28 Identities = 76/211 (36%), Positives = 118/211 (55%), Gaps = 2/211 (0%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A KII+ K++ A + + RE +I + L H N+V+ +D+ + Y+V +L G Sbjct: 38 QEYAAKIINTKKLS-ARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTG 95 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL + I+AR Y+E DA + QIL V H +VHRDLKPEN L ++ + A +K Sbjct: 96 GELFEDIVARE-YYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVK 154 Query: 381 LIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 L DFGL+ ++ +++ G+ Y++PEVL + Y DIW+ GVI YILL G PF Sbjct: 155 LADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPF 214 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 W + +++ + + W +V+ EA Sbjct: 215 WDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 245
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 124 bits (312), Expect = 2e-28 Identities = 75/216 (34%), Positives = 118/216 (54%), Gaps = 4/216 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 Y G+ A+KII KAK + + EV IL+ + H N++ + E A ++++VMEL Sbjct: 414 YTGKEFALKIIDKAKCCGKEHL--IENEVSILRRVK-HPNIIMLVEEMETATDLFLVMEL 470 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTT-RDEN 368 +GG+L D I + +YTE D A+V + + + + H +VHRD+KPEN L D Sbjct: 471 VKGGDLFDAITS-STKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGT 529 Query: 369 APMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGS 545 +KL DFGL+ + + L + G+ YVAPE++ Y ++ D+W+ GVITYILLCG Sbjct: 530 KSLKLGDFGLATVV--EGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGF 587 Query: 546 RPFWART--ESGIFRSVLRADPNLDDSPWPSVSAEA 647 PF + + +F +L W +++ A Sbjct: 588 PPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 623
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 124 bits (312), Expect = 2e-28 Identities = 78/219 (35%), Positives = 120/219 (54%), Gaps = 10/219 (4%) Frame = +3 Query: 21 QTVAVKIISK-----AKMTTAISIED-VRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 Q A+KI+ K A+ +T S D V E KI+K LS H +V+ +D + +VY+V Sbjct: 198 QQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLS-HPCVVRMHDIVDKPDSVYMV 256 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +E GG+LL+RI++ +E+ +K Q+ V + H +G+ HRDLKP+N L T D Sbjct: 257 LEFMRGGDLLNRIISNK-LLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETND 315 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL----HRSYSMEADIWSIGVITYI 530 E +K+ DFGLS F++ D + + G+ YVAPEVL +Y+ + DIWS+GV+ + Sbjct: 316 EETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFT 375 Query: 531 LLCGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 L G+ PF + + + + W SVS A Sbjct: 376 CLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRA 414
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 124 bits (311), Expect = 2e-28 Identities = 71/195 (36%), Positives = 111/195 (56%), Gaps = 2/195 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G+ VA+K I K K+ + +RRE++I+ +L+ H +++ Y+ E+ + I+ME Sbjct: 76 FSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN-HPHIISIYEVFENKDKIVIIMEY 134 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 GEL D I R R +E + + QI+S V +CH GVVHRDLK EN L D+N Sbjct: 135 ASKGELYDYISERR-RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL---DDNC 190 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-SMEADIWSIGVITYILLCGS 545 +K+ DFGLS+ + D+ L GS Y +PE+++ R Y E D W++GV+ Y L+ G+ Sbjct: 191 NIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGT 250 Query: 546 RPFWARTESGIFRSV 590 PF + R + Sbjct: 251 MPFDGFDHKNLIRQI 265
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 124 bits (311), Expect = 2e-28 Identities = 76/210 (36%), Positives = 117/210 (55%), Gaps = 4/210 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+KII K+K + ++ EV IL+ + H N+V + + +Y+VMEL +GG+L Sbjct: 433 ALKIIKKSKCRGKEHM--IQNEVSILRRVK-HPNIVLLIEEMDVPTELYLVMELVKGGDL 489 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFL-FTTRDENAPMKLI 386 D I + +YTE DA ++ + S + + H +VHRD+KPEN L + +D + +KL Sbjct: 490 FDAITSTS-KYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLG 548 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGL+ + D L + G+ YVAPE++ Y ++ DIW+ GVITYILLCG PF Sbjct: 549 DFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGS 606 Query: 564 --TESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +F +L + W +VS A Sbjct: 607 GDDQEVLFDQILMGQVDFPSPYWDNVSDSA 636
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 124 bits (311), Expect = 2e-28 Identities = 76/210 (36%), Positives = 117/210 (55%), Gaps = 4/210 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+KII K+K + ++ EV IL+ + H N+V + + +Y+VMEL +GG+L Sbjct: 110 ALKIIKKSKCRGKEHM--IQNEVSILRRVK-HPNIVLLIEEMDVPTELYLVMELVKGGDL 166 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFL-FTTRDENAPMKLI 386 D I + +YTE DA ++ + S + + H +VHRD+KPEN L + +D + +KL Sbjct: 167 FDAITSTS-KYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLG 225 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGL+ + D L + G+ YVAPE++ Y ++ DIW+ GVITYILLCG PF Sbjct: 226 DFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGS 283 Query: 564 --TESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +F +L + W +VS A Sbjct: 284 GDDQEVLFDQILMGQVDFPSPYWDNVSDSA 313
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 124 bits (311), Expect = 2e-28 Identities = 76/210 (36%), Positives = 117/210 (55%), Gaps = 4/210 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+KII K+K + ++ EV IL+ + H N+V + + +Y+VMEL +GG+L Sbjct: 417 ALKIIKKSKCRGKEHM--IQNEVSILRRVK-HPNIVLLIEEMDVPTELYLVMELVKGGDL 473 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFL-FTTRDENAPMKLI 386 D I + +YTE DA ++ + S + + H +VHRD+KPEN L + +D + +KL Sbjct: 474 FDAITSTN-KYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLG 532 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFGL+ + D L + G+ YVAPE++ Y ++ DIW+ GVITYILLCG PF Sbjct: 533 DFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGS 590 Query: 564 --TESGIFRSVLRADPNLDDSPWPSVSAEA 647 + +F +L + W +VS A Sbjct: 591 GDDQEVLFDQILMGQVDFPSPYWDNVSDSA 620
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 124 bits (310), Expect = 3e-28 Identities = 80/222 (36%), Positives = 117/222 (52%), Gaps = 12/222 (5%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ AVKI+S+ + +REV L+ H N+V ++ D L+ Y+V+EL Sbjct: 434 GQEFAVKILSRRLEA------NTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLR 487 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQ-GVVHRDLKPENFLFTTRDENAP 374 GGELL+ I + ++E +A I+ ++S V+F H + GVVHRDLKPEN L+ AP Sbjct: 488 GGELLEHIRKKR-HFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP 546 Query: 375 MKLIDFGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCG 542 +K+IDFG + +RP + + Y APE+L + Y D+WS+GVI Y++L G Sbjct: 547 VKIIDFGFAR-LRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSG 605 Query: 543 SRPFWARTESG-------IFRSVLRADPNLDDSPWPSVSAEA 647 PF + G I + +LD W VS EA Sbjct: 606 QVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 647 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/209 (27%), Positives = 104/209 (49%), Gaps = 9/209 (4%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTT-AISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 G G+ A+K++ KA + A + E R E +L+ + LV + A + ++++ Sbjct: 55 GHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLI 114 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGE+ + R + E + + +I+ + H G+++RDLK EN L D Sbjct: 115 LDYVSGGEMFTHLYQRQ-YFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLL---D 170 Query: 363 ENAPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYI 530 + L DFGLS +F+ + ER G+ Y+APE++ + D WS+G++ + Sbjct: 171 SEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFE 230 Query: 531 LLCGSRPFW----ARTESGIFRSVLRADP 605 LL G+ PF T++ + R +L+ P Sbjct: 231 LLTGASPFTLEGERNTQAEVSRRILKCSP 259
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 123 bits (309), Expect = 4e-28 Identities = 70/181 (38%), Positives = 108/181 (59%), Gaps = 2/181 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ VA+KI+++ K++ ++ ++ V RE+ ILK + H +++K +D E+ +Y+V+E Sbjct: 73 GQKVAIKIVNREKLSESVLMK-VEREIAILKLIE-HPHVLKLHDVYENKKYLYLVLEHVS 130 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL D L + GR T ++A+ QI+S + FCH + HRDLKPEN L DE + Sbjct: 131 GGELFD-YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLL---DEKNNI 186 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSMEADIWSIGVITYILLCGSRP 551 ++ DFG++ D L GS +Y PEV+ + AD+WS GVI + LL G+ P Sbjct: 187 RIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALP 246 Query: 552 F 554 F Sbjct: 247 F 247
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 123 bits (308), Expect = 5e-28 Identities = 69/180 (38%), Positives = 108/180 (60%), Gaps = 2/180 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q VA+KI+++ K++ ++ ++ V RE+ ILK + H +++K +D E+ +Y+V+E G Sbjct: 43 QKVAIKIVNREKLSESVLMK-VEREIAILKLIE-HPHVLKLHDVYENKKYLYLVLEHVSG 100 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL D L + GR T ++A+ QI+S + FCH + HRDLKPEN L DE ++ Sbjct: 101 GELFD-YLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLL---DEKNNIR 156 Query: 381 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSMEADIWSIGVITYILLCGSRPF 554 + DFG++ D L GS +Y PEV+ + +AD+WS GVI + LL G+ PF Sbjct: 157 IADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPF 216
>MYLK2_RAT (P20689) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 609 Score = 123 bits (308), Expect = 5e-28 Identities = 77/211 (36%), Positives = 117/211 (55%), Gaps = 1/211 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G +A K+I K T E V E++++ L+ H NL++ Y A E + + + ME E Sbjct: 321 GLKLAAKVIKKQ---TPKDKEMVLLEIEVMNQLN-HRNLIQLYSAIETSHEIILFMEYIE 376 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL +RI+ + TE D V QI + F H V+H DLKPEN L + + Sbjct: 377 GGELFERIVDEDYQLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHL-V 435 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 K+IDFGL+ P+E+L G+ +++PEV+ + S + D+WS+GVITY+LL G PF Sbjct: 436 KIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPF 495 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +VL A+ D+ + +VS EA Sbjct: 496 LGDDDTETLNNVLSANWYFDEETFEAVSDEA 526
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 123 bits (308), Expect = 5e-28 Identities = 68/212 (32%), Positives = 118/212 (55%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K + K + +E + E+ +L+ + ++ ++ E + + +V+E Sbjct: 67 GKEFAAKFMRKRRKGQDCRMEIIH-EIAVLELAQDNPWVINLHEVYETSSEMILVLEYAA 125 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 GGE+ D+ +A R + E+D + ++ QIL V F H VVH DLKP+N L T+ Sbjct: 126 GGEISDQCVADRDEAFNEKDVQRLMRQILEGVHFLHTHDVVHLDLKPQNILLTSESPLGD 185 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRP 551 +K++DFGLS ++ E L +I+G+ YVAPE+L + SM D+WSIGV+TY++L G P Sbjct: 186 IKIVDFGLSRIVKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISP 245 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + F ++ + + + + + +VS A Sbjct: 246 FLGDNKQETFLNISQMNLSYSEEEFDTVSESA 277
>MAPK2_DROME (P49071) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) Length = 359 Score = 122 bits (307), Expect = 7e-28 Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 10/200 (5%) Frame = +3 Query: 78 EDVRREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARG-GRY 242 E RREV + +SG +V D E+ + +VME EGGEL RI + G + Sbjct: 55 ERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAF 114 Query: 243 TEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDE 422 TE +A I+ +I + V + H + + HRDLKPEN L+TT NA +KL DFG + Sbjct: 115 TEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSY 174 Query: 423 RLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR----TESGIFRS 587 L + YYVAPEVL Y DIWS+GV+ YI++CG PF++ G+ Sbjct: 175 TLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNR 234 Query: 588 VLRADPNLDDSPWPSVSAEA 647 + + D W +VS A Sbjct: 235 IRTGQYDFPDPEWTNVSQAA 254
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 122 bits (306), Expect = 9e-28 Identities = 68/212 (32%), Positives = 118/212 (55%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K + K + +E + E+ +L+ + ++ ++ E A + +V+E Sbjct: 84 GKEFAAKFMRKRRKGQDCRMEIIH-EIAVLELAQDNPWVINLHEVYETASEMILVLEYAA 142 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 GGE+ D+ +A R + E+D + ++ QIL V F H + VVH DLKP+N L T+ Sbjct: 143 GGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGD 202 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRP 551 +K++DFGLS ++ E L +I+G+ YVAPE+L + SM D+WSIGV+TY++L G P Sbjct: 203 IKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISP 262 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + F ++ + + + + + +S A Sbjct: 263 FLGNDKQETFLNISQMNLSYSEEEFDVLSESA 294
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 121 bits (304), Expect = 2e-27 Identities = 75/214 (35%), Positives = 117/214 (54%), Gaps = 4/214 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A+KII KAK + + EV IL+ + H N++ + E A +++VMEL + Sbjct: 417 GKEFALKIIDKAKCCGKEHL--IENEVSILRRVK-HPNIIMLVEEMETATELFLVMELVK 473 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTR-DENAP 374 GG+L D I + +YTE D A+V + + + + H +VHRD+KPEN L D Sbjct: 474 GGDLFDAITS-STKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKS 532 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 +KL DFGL+ + + L + G+ YVAPE++ + Y ++ DIW+ GVITYILLCG P Sbjct: 533 LKLGDFGLATVV--EGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPP 590 Query: 552 FWART--ESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + + +F +L W +++ A Sbjct: 591 FRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 624
>MYLK_CHICK (P11799) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin] Length = 1906 Score = 120 bits (302), Expect = 3e-27 Identities = 72/199 (36%), Positives = 108/199 (54%), Gaps = 1/199 (0%) Frame = +3 Query: 54 KMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARG 233 K +A E++R E+ I+ L H LV+ DA E+ N+ +V+E+ GGEL +RI+ Sbjct: 1485 KAYSAKEKENIRDEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEMVSGGELFERIIDED 1543 Query: 234 GRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIR 413 TE + + QI V + H QG+VH DLKPEN + + +KLIDFGL+ + Sbjct: 1544 FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTSIKLIDFGLARRLE 1602 Query: 414 PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSV 590 L + G+ +VAPEV+ + E D+WSIGVI YIL+ G PF ++ +V Sbjct: 1603 SAGSLKVLFGTPEFVAPEVINYEPIGYETDMWSIGVICYILVSGLSPFMGDNDNETLANV 1662 Query: 591 LRADPNLDDSPWPSVSAEA 647 A + DD + +S +A Sbjct: 1663 TSATWDFDDEAFDEISDDA 1681
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 120 bits (301), Expect = 3e-27 Identities = 79/217 (36%), Positives = 116/217 (53%), Gaps = 10/217 (4%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIE-----DVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 VA+KIISK K + E +V E++ILK L+ H ++K + DA + YIV+EL Sbjct: 246 VAIKIISKRKFAIGSAREADPALNVETEIEILKKLN-HPCIIKIKNFF-DAEDYYIVLEL 303 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 EGGEL D+++ R E K Q+L V + H G++HRDLKPEN L ++++E+ Sbjct: 304 MEGGELFDKVVGNK-RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC 362 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL----HRSYSMEADIWSIGVITYILLC 539 +K+ DFG S + + + G+ Y+APEVL Y+ D WS+GVI +I L Sbjct: 363 LIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS 422 Query: 540 GSRPFWA-RTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF RT+ + + N W VS +A Sbjct: 423 GYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKA 459
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 120 bits (300), Expect = 5e-27 Identities = 69/195 (35%), Positives = 114/195 (58%), Gaps = 4/195 (2%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A K+I+K + + + E+K+ +++S H N+V F D ED+ N+Y+++ELCE Sbjct: 63 GNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMS-HPNIVGFIDCFEDSTNIYLILELCE 121 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 L++ +L + + TE + + +++QIL + + H + V+HRDLK N + DE+ + Sbjct: 122 HKSLME-LLRKRKQLTEPEVRYLMMQILGALKYMHKKRVIHRDLKLGNIML---DESNNV 177 Query: 378 KLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVLHRS---YSMEADIWSIGVITYILLCGS 545 K+ DFGL+ + D ER I G+ Y+APE+L S +S E D+WS GV+ Y LL G Sbjct: 178 KIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGK 237 Query: 546 RPFWARTESGIFRSV 590 PF + I+R + Sbjct: 238 PPFQDKEVKTIYRKI 252
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 120 bits (300), Expect = 5e-27 Identities = 71/193 (36%), Positives = 106/193 (54%), Gaps = 2/193 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ VA+KII++ + + V RE+ L+ L H +++K YD + + +V+E Sbjct: 75 GQKVALKIINRKTLAKSDMQGRVEREISYLRLLR-HPHIIKLYDVIKSKDEIIMVIEFA- 132 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 G EL D I+ RG + E++A+ QI++ V +CH +VHRDLKPEN L D+ + Sbjct: 133 GKELFDYIVQRG-KMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPENLLL---DDQLNV 188 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRP 551 K+ DFGLS+ + L GS Y APEV+ E D+WS GVI Y++LCG P Sbjct: 189 KIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSSGVILYVMLCGRLP 248 Query: 552 FWARTESGIFRSV 590 F +F+ + Sbjct: 249 FDDEFIPALFKKI 261
>MYLK2_RABIT (P07313) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 607 Score = 120 bits (300), Expect = 5e-27 Identities = 76/211 (36%), Positives = 114/211 (54%), Gaps = 1/211 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G +A K+I K T E V E++++ L+ H NL++ Y A E + + ME E Sbjct: 319 GLKLAAKVIKKQ---TPKDKEMVMLEIEVMNQLN-HRNLIQLYAAIETPHEIVLFMEYIE 374 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL +RI+ TE D V QI + F H V+H DLKPEN L + + Sbjct: 375 GGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHL-V 433 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 K+IDFGL+ P+E+L G+ +++PEV+ + S + D+WS+GVITY+LL G PF Sbjct: 434 KIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPF 493 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +VL + D+ + +VS EA Sbjct: 494 LGDDDTETLNNVLSGNWYFDEETFEAVSDEA 524
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 119 bits (299), Expect = 6e-27 Identities = 66/181 (36%), Positives = 104/181 (57%), Gaps = 2/181 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G VA+KI+++ +M ++ R E+ L+ L+ H ++ + + ++++VMEL Sbjct: 47 GYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLT-HPHITRLFRVISTPSDIFLVMELVS 105 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL I +G E ++ QI+S V++CH +VHRDLKPEN L D N + Sbjct: 106 GGELFSYITRKGALPIRE-SRRYFQQIISGVSYCHNHMIVHRDLKPENLLL---DANKNI 161 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSM--EADIWSIGVITYILLCGSRP 551 K+ DFGLS+++ + L+ GS Y APE++ + E D+WS GVI Y +LCG+ P Sbjct: 162 KIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLP 221 Query: 552 F 554 F Sbjct: 222 F 222
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 119 bits (299), Expect = 6e-27 Identities = 71/193 (36%), Positives = 108/193 (55%), Gaps = 2/193 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ VA+KII+K + + + RE+ L+ L H +++K YD + + +V+E Sbjct: 62 GQKVALKIINKKVLAKSDMQGRIEREISYLRLLR-HPHIIKLYDVIKSKDEIIMVIEYA- 119 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 G EL D I+ R + +E++A+ QI+S V +CH +VHRDLKPEN L DE+ + Sbjct: 120 GNELFDYIVQRN-KMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLL---DEHLNV 175 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRP 551 K+ DFGLS+ + L GS Y APEV+ E D+WS GVI Y++LC P Sbjct: 176 KIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLP 235 Query: 552 FWARTESGIFRSV 590 F + +F+++ Sbjct: 236 FDDESIPVLFKNI 248
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 119 bits (299), Expect = 6e-27 Identities = 73/204 (35%), Positives = 113/204 (55%), Gaps = 1/204 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G V VK + K+K+ + +V E+++L+ + H ++K A E VY+V+E + Sbjct: 134 GNRVVVKEVDKSKVKES----NVYTEIEVLRKVM-HKYIIKLISAYEQEGFVYLVLEYLK 188 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL + L G YTE+ AK + ++L + H GVVHRDLK EN + ++ + + Sbjct: 189 GGELFE-YLNNNGPYTEQVAKKAMKRVLIALEALHSNGVVHRDLKMENLMLENPNDPSSL 247 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPF 554 K+IDFGL+ F+ +N GS YVAPE+L SY + DI+S+GVI + +LCG PF Sbjct: 248 KIIDFGLASFLN-SPSMNMRCGSPGYVAPEILKCASYGTKVDIFSLGVILFNILCGYPPF 306 Query: 555 WARTESGIFRSVLRADPNLDDSPW 626 IF+ +R + + W Sbjct: 307 RGNNVKEIFKKNMRCHISFNTKHW 330
>MYLK_BOVIN (Q28824) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1176 Score = 119 bits (298), Expect = 8e-27 Identities = 71/199 (35%), Positives = 108/199 (54%), Gaps = 1/199 (0%) Frame = +3 Query: 54 KMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARG 233 K +A E++R+E+ I+ L H LV+ DA E+ N+ +V+E+ GGEL +RI+ Sbjct: 757 KAYSAKEKENIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED 815 Query: 234 GRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIR 413 TE + + QI V + H QG+VH DLKPEN + + +KLIDFGL+ + Sbjct: 816 FELTERECIKYMKQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIKLIDFGLARRLE 874 Query: 414 PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSV 590 L + G+ +VAPEV+ + D+WSIGVI YIL+ G PF ++ +V Sbjct: 875 NAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANV 934 Query: 591 LRADPNLDDSPWPSVSAEA 647 A + DD + +S +A Sbjct: 935 TSATWDFDDEAFDEISDDA 953
>MYLK_SHEEP (O02827) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] (Fragment) Length = 438 Score = 119 bits (298), Expect = 8e-27 Identities = 71/199 (35%), Positives = 108/199 (54%), Gaps = 1/199 (0%) Frame = +3 Query: 54 KMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARG 233 K +A E++R+E+ I+ L H LV+ DA E+ N+ +V+E+ GGEL +RI+ Sbjct: 18 KAYSAKEKENIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED 76 Query: 234 GRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIR 413 TE + + QI V + H QG+VH DLKPEN + + +KLIDFGL+ + Sbjct: 77 FELTERECIKYMKQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIKLIDFGLARRLE 135 Query: 414 PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSV 590 L + G+ +VAPEV+ + D+WSIGVI YIL+ G PF ++ +V Sbjct: 136 NAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANV 195 Query: 591 LRADPNLDDSPWPSVSAEA 647 A + DD + +S +A Sbjct: 196 TSATWDFDDEAFDEISDDA 214
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 119 bits (298), Expect = 8e-27 Identities = 71/193 (36%), Positives = 108/193 (55%), Gaps = 2/193 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ VA+KII+K + + + RE+ L+ L H +++K YD + + +V+E Sbjct: 78 GQKVALKIINKKVLAKSDMQGRIEREISYLRLLR-HPHIIKLYDVIKSKDEIIMVIEYA- 135 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 G EL D I+ R + +E++A+ QI+S V +CH +VHRDLKPEN L DE+ + Sbjct: 136 GNELFDYIVQRD-KMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLL---DEHLNV 191 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRP 551 K+ DFGLS+ + L GS Y APEV+ E D+WS GVI Y++LC P Sbjct: 192 KIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLP 251 Query: 552 FWARTESGIFRSV 590 F + +F+++ Sbjct: 252 FDDESIPVLFKNI 264
>MYLK2_HUMAN (Q9H1R3) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 595 Score = 119 bits (298), Expect = 8e-27 Identities = 76/211 (36%), Positives = 114/211 (54%), Gaps = 1/211 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G +A K+I K T E V E++++ L+ H NL++ Y A E + + ME E Sbjct: 307 GLKLAAKVIKKQ---TPKDKEMVLLEIEVMNQLN-HRNLIQLYAAIETPHEIVLFMEYIE 362 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL +RI+ TE D V QI + F H V+H DLKPEN L + + Sbjct: 363 GGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHL-V 421 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 K+IDFGL+ P+E+L G+ +++PEV+ + S + D+WS+GVITY+LL G PF Sbjct: 422 KIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPF 481 Query: 555 WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 ++ +VL + D+ + +VS EA Sbjct: 482 LGDDDTETLNNVLSGNWYFDEETFEAVSDEA 512
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 119 bits (298), Expect = 8e-27 Identities = 73/178 (41%), Positives = 100/178 (56%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVKII K+K D E++IL H N++ D +D VY+V EL +GGEL Sbjct: 449 AVKIIDKSK-------RDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGEL 501 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN-APMKLI 386 LD+IL R ++E +A A++ I V + H QGVVHRDLKP N L+ N +++ Sbjct: 502 LDKIL-RQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRIC 560 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL R Y DIWS+GV+ Y +L G PF Sbjct: 561 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF 618 Score = 99.4 bits (246), Expect = 8e-21 Identities = 62/195 (31%), Positives = 107/195 (54%), Gaps = 2/195 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A+K++ KA + + + E IL ++ H +VK + A + +Y++++ G Sbjct: 95 QLYAMKVLKKATLKVRDRVR-TKMERDILVEVN-HPFIVKLHYAFQTEGKLYLILDFLRG 152 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE +K Sbjct: 153 GDLFTR-LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIK 208 Query: 381 LIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPF 554 L DFGLS + I +++ G+ Y+APEV++ R ++ AD WS GV+ + +L G+ PF Sbjct: 209 LTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPF 268 Query: 555 WARTESGIFRSVLRA 599 + +L+A Sbjct: 269 QGKDRKETMTMILKA 283
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 119 bits (298), Expect = 8e-27 Identities = 73/178 (41%), Positives = 100/178 (56%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVKII K+K D E++IL H N++ D +D VY+V EL +GGEL Sbjct: 449 AVKIIDKSK-------RDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGEL 501 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN-APMKLI 386 LD+IL R ++E +A A++ I V + H QGVVHRDLKP N L+ N +++ Sbjct: 502 LDKIL-RQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRIC 560 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL R Y DIWS+GV+ Y +L G PF Sbjct: 561 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF 618 Score = 99.4 bits (246), Expect = 8e-21 Identities = 62/195 (31%), Positives = 107/195 (54%), Gaps = 2/195 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A+K++ KA + + + E IL ++ H +VK + A + +Y++++ G Sbjct: 95 QLYAMKVLKKATLKVRDRVR-TKMERDILVEVN-HPFIVKLHYAFQTEGKLYLILDFLRG 152 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE +K Sbjct: 153 GDLFTR-LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIK 208 Query: 381 LIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPF 554 L DFGLS + I +++ G+ Y+APEV++ R ++ AD WS GV+ + +L G+ PF Sbjct: 209 LTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPF 268 Query: 555 WARTESGIFRSVLRA 599 + +L+A Sbjct: 269 QGKDRKETMTMILKA 283
>MYLK_HUMAN (Q15746) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1914 Score = 119 bits (297), Expect = 1e-26 Identities = 71/199 (35%), Positives = 108/199 (54%), Gaps = 1/199 (0%) Frame = +3 Query: 54 KMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARG 233 K +A E++R+E+ I+ L H LV+ DA E+ N+ +V+E+ GGEL +RI+ Sbjct: 1496 KAYSAKEKENIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED 1554 Query: 234 GRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIR 413 TE + + QI V + H QG+VH DLKPEN + + +KLIDFGL+ + Sbjct: 1555 FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIKLIDFGLARRLE 1613 Query: 414 PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSV 590 L + G+ +VAPEV+ + D+WSIGVI YIL+ G PF ++ +V Sbjct: 1614 NAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANV 1673 Query: 591 LRADPNLDDSPWPSVSAEA 647 A + DD + +S +A Sbjct: 1674 TSATWDFDDEAFDEISDDA 1692
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 119 bits (297), Expect = 1e-26 Identities = 74/212 (34%), Positives = 114/212 (53%), Gaps = 6/212 (2%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVKI+ KA + D EV IL S H +VK +D ED +Y++ ELCEGGEL Sbjct: 481 AVKIVKKA-------VFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGEL 533 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD-ENAPMKLI 386 LD+++ + +E++ AI+ +L+ V + H Q V HRDL N LF +D + + ++++ Sbjct: 534 LDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIV 593 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFWA 560 DFG + R + L +A +VAPEVL + Y D+WS+GV+ + +L G PF Sbjct: 594 DFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAM 653 Query: 561 ---RTESGIFRSVLRADPNLDDSPWPSVSAEA 647 T I + V ++ W ++S EA Sbjct: 654 GPNDTPDQILQRVGDGKISMTHPVWDTISDEA 685 Score = 106 bits (265), Expect = 5e-23 Identities = 67/204 (32%), Positives = 113/204 (55%), Gaps = 5/204 (2%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRR---EVKILKALSGHNNLVKFYDACEDALNV 173 +G G A+K++ KA + + D +R E IL +S H +VK + A + + Sbjct: 125 RGRDSGHVYAMKVLKKA----TLKVRDRQRTKLERNILAHIS-HPFIVKLHYAFQTEGKL 179 Query: 174 YIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT 353 Y++++ GG+L R L++ +TE+D K + ++ + H G+V+RDLKPEN L Sbjct: 180 YLILDFLRGGDLFTR-LSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILL- 237 Query: 354 TRDENAPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITY 527 D + +K+ DFGLS + I +++ G+ Y+APEV++R +SM AD WS+GV+ + Sbjct: 238 --DADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMF 295 Query: 528 ILLCGSRPFWARTESGIFRSVLRA 599 +L G PF R + +L+A Sbjct: 296 EMLTGHLPFQGRDRNDTMTQILKA 319
>MAPK3_RAT (Q66H84) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 118 bits (296), Expect = 1e-26 Identities = 75/197 (38%), Positives = 106/197 (53%), Gaps = 10/197 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 R+EV SG ++V+ D E+ + + IVME EGGEL RI RG + +TE Sbjct: 84 RQEVDHHWQASGGPHIVRILDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTER 143 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + F H Q + HRD+KPEN L+T+++++A +KL DFG + L Sbjct: 144 EAAEIMRDIGTAIQFLHSQNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQ 202 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWART----ESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ T G+ R + Sbjct: 203 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 262 Query: 597 ADPNLDDSPWPSVSAEA 647 W VS +A Sbjct: 263 GQYGFPKPEWADVSEDA 279
>MAPK3_BOVIN (Q3SYZ2) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 118 bits (296), Expect = 1e-26 Identities = 74/197 (37%), Positives = 106/197 (53%), Gaps = 10/197 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 R+EV SG ++V+ D E+ + + I+ME EGGEL RI RG + +TE Sbjct: 84 RQEVDHHWQASGGPHIVRILDVYENMHHSKRCLLIIMECMEGGELFSRIQERGDQAFTER 143 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + F H + + HRD+KPEN L+T++D++A +KL DFG + L Sbjct: 144 EAAEIMRDIGTAIQFLHSRNIAHRDVKPENLLYTSKDKDAVLKLTDFGFAK-ETTQNALQ 202 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWART----ESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ T G+ R + Sbjct: 203 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 262 Query: 597 ADPNLDDSPWPSVSAEA 647 W VS +A Sbjct: 263 GQYGFPSPEWSEVSEDA 279
>MYLK_MOUSE (Q6PDN3) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1941 Score = 117 bits (294), Expect = 2e-26 Identities = 70/199 (35%), Positives = 108/199 (54%), Gaps = 1/199 (0%) Frame = +3 Query: 54 KMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARG 233 K +A +++R+E+ I+ L H LV+ DA E+ N+ +V+E+ GGEL +RI+ Sbjct: 1518 KAYSAKEKDNIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED 1576 Query: 234 GRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIR 413 TE + + QI V + H QG+VH DLKPEN + + +KLIDFGL+ + Sbjct: 1577 FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIKLIDFGLARRLE 1635 Query: 414 PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSV 590 L + G+ +VAPEV+ + D+WSIGVI YIL+ G PF ++ +V Sbjct: 1636 NAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANV 1695 Query: 591 LRADPNLDDSPWPSVSAEA 647 A + DD + +S +A Sbjct: 1696 TSATWDFDDEAFDEISDDA 1714
>MKNK1_XENTR (Q66JF3) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 417 Score = 117 bits (294), Expect = 2e-26 Identities = 78/239 (32%), Positives = 112/239 (46%), Gaps = 29/239 (12%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ AVKI+ K S V REV+ L G+ N+++ + CED Y+V E Sbjct: 60 GKDYAVKIVEKK---AGHSRSRVFREVETLYQCQGNKNILELIEFCEDDARFYLVFEKLR 116 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG +L I R + E +A +V I S + F H +G+ HRDLKPEN L +D+ +P+ Sbjct: 117 GGSILSHIQKRK-HFNEREASKVVKDIASALDFLHTKGIAHRDLKPENILCEFKDKVSPV 175 Query: 378 KLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSMEADIWSIG 515 K+ DF L ++ + I GSA Y+APEV+ Y D+WS+G Sbjct: 176 KICDFDLGSGVKLNSACTPITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLG 235 Query: 516 VITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 VI YI+L G PF W R E + +F S+ + W +S A Sbjct: 236 VILYIMLSGYPPFVGNCGADCGWDRGEMCRVCQNKLFESIQEGKYEFPEKDWSHISNSA 294
>MAPK3_MOUSE (Q3UMW7) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 117 bits (293), Expect = 3e-26 Identities = 74/197 (37%), Positives = 108/197 (54%), Gaps = 10/197 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 R+EV SG ++V+ D E+ + + IVME EGGEL RI RG + +TE Sbjct: 84 RQEVDHHWQASGGPHIVRILDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTER 143 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + F H + + HRD+KPEN L+T+++++A +KL DFG + L Sbjct: 144 EAAEIMRDIGTAIQFLHSRNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQ 202 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWART----ESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ T G+ R + Sbjct: 203 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 262 Query: 597 ADPNLDDSPWPSVSAEA 647 + + W VS +A Sbjct: 263 GQYSFPNPEWLDVSEDA 279
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 117 bits (293), Expect = 3e-26 Identities = 67/170 (39%), Positives = 98/170 (57%), Gaps = 9/170 (5%) Frame = +3 Query: 165 LNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENF 344 L+ ++VMEL GGEL +RI R ++E +A I+ +++S V+ H GVVHRDLKPEN Sbjct: 556 LHTFLVMELLNGGELFERI-KRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENL 614 Query: 345 LFTTRDENAPMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVL-HRSYSMEADIWSIGV 518 LFT ++N +K+IDFG + PD + L + +Y APE+L H Y D+WS+GV Sbjct: 615 LFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGV 674 Query: 519 ITYILLCGSRPFWARTES-------GIFRSVLRADPNLDDSPWPSVSAEA 647 I Y +L G PF + S I + + + D + + W +VS EA Sbjct: 675 ILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 724 Score = 92.8 bits (229), Expect = 8e-19 Identities = 62/210 (29%), Positives = 111/210 (52%), Gaps = 10/210 (4%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTT-AISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 G G+ A+K++ KA + A + E R E ++L+ + LV + A + ++++ Sbjct: 70 GHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLI 129 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GGEL + R R+TE + + V +I+ + H G+++RD+K EN L D Sbjct: 130 LDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL---D 185 Query: 363 ENAPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLH---RSYSMEADIWSIGVITY 527 N + L DFGLS +F+ + ER G+ Y+AP+++ + D WS+GV+ Y Sbjct: 186 SNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMY 245 Query: 528 ILLCGSRPFWA----RTESGIFRSVLRADP 605 LL G+ PF +++ I R +L+++P Sbjct: 246 ELLTGASPFTVDGEKNSQAEISRRILKSEP 275
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha| 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 117 bits (293), Expect = 3e-26 Identities = 78/212 (36%), Positives = 110/212 (51%), Gaps = 6/212 (2%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I K+K D E++IL H N++ D +D+ +VY+V EL GGEL Sbjct: 445 AVKVIDKSK-------RDPSEEIEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGEL 497 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP-MKLI 386 LD+IL R ++E +A ++ I V + H QGVVHRDLKP N L+ N +++ Sbjct: 498 LDKIL-RQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 556 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFW- 557 DFG + +R + L +A +VAPEVL R Y DIWS+GV+ Y +L G PF Sbjct: 557 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTPFAN 616 Query: 558 --ARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 + T I + L W +VS A Sbjct: 617 GPSDTPEEILTRISSGKFTLSGGNWNTVSETA 648 Score = 97.8 bits (242), Expect = 2e-20 Identities = 63/196 (32%), Positives = 107/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A+K++ KA + + + E IL ++ H +VK + A + +Y++++ Sbjct: 88 GHLYAMKVLKKATLKVRDRVR-TKMERDILADVN-HPFVVKLHYAFQTEGKLYLILDFLR 145 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE + Sbjct: 146 GGDLFTR-LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHI 201 Query: 378 KLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRP 551 KL DFGLS + I +++ G+ Y+APEV++R ++ AD WS GV+ + +L GS P Sbjct: 202 KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLP 261 Query: 552 FWARTESGIFRSVLRA 599 F + +L+A Sbjct: 262 FQGKDRKETMTLILKA 277
>MKNK1_XENLA (Q9YGW0) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 418 Score = 117 bits (292), Expect = 4e-26 Identities = 78/239 (32%), Positives = 112/239 (46%), Gaps = 29/239 (12%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ AVKI+ K S V REV+ L G+ N+++ + CED Y+V E Sbjct: 60 GKDYAVKIVEKK---AGHSRSRVFREVETLYQCQGNKNILELIEFCEDDARFYLVFEKLL 116 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG +L I R + E +A +V I S + F H +G+ HRDLKPEN L +D+ +P+ Sbjct: 117 GGSILSHIQKRK-HFNEREASKVVKDIASALDFLHTKGIAHRDLKPENILCEFKDKVSPV 175 Query: 378 KLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSMEADIWSIG 515 K+ DF L ++ + I GSA Y+APEV+ Y D+WS+G Sbjct: 176 KICDFDLGSGVKLNSACTTITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLG 235 Query: 516 VITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 VI YI+L G PF W R E + +F S+ + W +S A Sbjct: 236 VILYIMLSGYPPFVGNCGTDCGWDRGEVCRVCQNKLFESIQEGKYEFPEKDWSHISISA 294
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 116 bits (291), Expect = 5e-26 Identities = 71/178 (39%), Positives = 99/178 (55%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVKII K+K D E++IL H N++ D +D VY+VMEL GGEL Sbjct: 442 AVKIIDKSK-------RDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGEL 494 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN-APMKLI 386 LDRIL R ++E +A ++ I + + H QGVVHRDLKP N L+ N +++ Sbjct: 495 LDRIL-RQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRIC 553 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL R Y D+WS+G++ Y +L G PF Sbjct: 554 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPF 611 Score = 102 bits (254), Expect = 1e-21 Identities = 65/200 (32%), Positives = 108/200 (54%), Gaps = 2/200 (1%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVM 185 G GQ A+K++ KA + + + E IL ++ H +VK + A + +Y+++ Sbjct: 81 GSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVN-HPFIVKLHYAFQTEGKLYLIL 138 Query: 186 ELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDE 365 + GG+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE Sbjct: 139 DFLRGGDLFTR-LSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILL---DE 194 Query: 366 NAPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLC 539 +K+ DFGLS + D+R G+ Y+APEV++ R ++ AD WS GV+ + +L Sbjct: 195 EGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT 254 Query: 540 GSRPFWARTESGIFRSVLRA 599 GS PF + +L+A Sbjct: 255 GSLPFQGKDRKETMALILKA 274
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 116 bits (291), Expect = 5e-26 Identities = 69/192 (35%), Positives = 104/192 (54%), Gaps = 2/192 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q VA+K IS+ + + V RE+ LK L H +++K YD ++ +V+E G Sbjct: 58 QKVALKFISRQLLKKSDMHMRVEREISYLKLLR-HPHIIKLYDVITTPTDIVMVIEYA-G 115 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL D I+ + R TE++ + QI+ + +CH +VHRDLKPEN L D+N +K Sbjct: 116 GELFDYIVEKK-RMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLL---DDNLNVK 171 Query: 381 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRPF 554 + DFGLS+ + L GS Y APEV++ E D+WS G++ Y++L G PF Sbjct: 172 IADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPF 231 Query: 555 WARTESGIFRSV 590 +F+ V Sbjct: 232 DDEFIPNLFKKV 243
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 116 bits (291), Expect = 5e-26 Identities = 69/178 (38%), Positives = 101/178 (56%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I K+K D E++IL+ H N++ D E+ ++Y+V EL GGEL Sbjct: 443 AVKVIDKSK-------RDPSEEIEILRRYGQHPNIITLKDVYEECNSIYLVTELMRGGEL 495 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD-ENAPMKLI 386 LDRIL R ++E +A +++ + V + H QGVVHRDLKP N L+ + +++ Sbjct: 496 LDRIL-RQKFFSEREACSVLFTVCKTVEYLHSQGVVHRDLKPSNILYVDESGDPESIRIC 554 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG S +R + L +A +VAPEVL R Y DIWS+G++ Y +L G PF Sbjct: 555 DFGFSKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF 612 Score = 95.9 bits (237), Expect = 9e-20 Identities = 63/195 (32%), Positives = 106/195 (54%), Gaps = 2/195 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A+K++ KA + + + E IL + H +V+ + A + +Y++++ G Sbjct: 89 QLYAMKVLKKATLKVRDRVR-TKMERDILADVH-HPFVVRLHYAFQTEGKLYLILDFLRG 146 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE +K Sbjct: 147 GDLFTR-LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHIK 202 Query: 381 LIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 L DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ + +L GS PF Sbjct: 203 LTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHGADWWSYGVLMFEMLTGSLPF 262 Query: 555 WARTESGIFRSVLRA 599 + +L+A Sbjct: 263 QGKDRKETMTLILKA 277
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 116 bits (290), Expect = 7e-26 Identities = 68/199 (34%), Positives = 114/199 (57%), Gaps = 2/199 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G VA+K+I K M A ++ V+ EVKI L H ++++ Y+ ED+ VY+V+E+ Sbjct: 33 HTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK-HPSILELYNYFEDSNYVYLVLEM 91 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GE+ + R ++E +A+ + QI++ + + H G++HRDL N L T N Sbjct: 92 CHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNM 148 Query: 372 PMKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGS 545 +K+ DFGL+ ++ P E+ + G+ Y++PE+ RS + +E+D+WS+G + Y LL G Sbjct: 149 NIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGR 208 Query: 546 RPFWARTESGIFRSVLRAD 602 PF T V+ AD Sbjct: 209 PPFDTDTVKNTLNKVVLAD 227
>MYLK_RABIT (P29294) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1147 Score = 116 bits (290), Expect = 7e-26 Identities = 71/199 (35%), Positives = 107/199 (53%), Gaps = 1/199 (0%) Frame = +3 Query: 54 KMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARG 233 K +A E++ E+ I+ L H LV+ DA E+ N+ +V+E+ GGEL +RI+ Sbjct: 728 KAYSAKEKENIPAEIGIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED 786 Query: 234 GRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIR 413 TE + + QI V + H QG+VH DLKPEN + + +KLIDFGL+ + Sbjct: 787 FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIKLIDFGLARRLE 845 Query: 414 PDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWARTESGIFRSV 590 L + G+ +VAPEV+ + S D+WSIGVI YIL+ G PF ++ +V Sbjct: 846 NAGSLKVLFGTPEFVAPEVINYEPISYATDMWSIGVICYILVSGLSPFMGDNDNETLANV 905 Query: 591 LRADPNLDDSPWPSVSAEA 647 A + DD + +S +A Sbjct: 906 TSATWDFDDEAFDEISDDA 924
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 116 bits (290), Expect = 7e-26 Identities = 74/180 (41%), Positives = 102/180 (56%), Gaps = 5/180 (2%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVKII K+K D E++IL H N++ D +D VY+VMEL GGEL Sbjct: 442 AVKIIDKSK-------RDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA---PMK 380 LDRIL R ++E +A ++ I + + H QGVVHRDLKP N L+ RDE+ ++ Sbjct: 495 LDRIL-RQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY--RDESGSPESIR 551 Query: 381 LIDFGLSDFIRP-DERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 + DFG + +R + L +A +VAPEVL R Y DIWS+G++ Y +L G PF Sbjct: 552 VCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF 611 Score = 107 bits (266), Expect = 4e-23 Identities = 67/201 (33%), Positives = 110/201 (54%), Gaps = 2/201 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 KG GQ A+K++ KA + + + E IL ++ H +VK + A + +Y++ Sbjct: 80 KGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVN-HPFIVKLHYAFQTEGKLYLI 137 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 ++ GG+L R L++ +TEED K + ++ + H G+++RDLKPEN L D Sbjct: 138 LDFLRGGDLFTR-LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL---D 193 Query: 363 ENAPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILL 536 E +K+ DFGLS + I D+R G+ Y+APEV++ R ++ AD WS GV+ + +L Sbjct: 194 EEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEML 253 Query: 537 CGSRPFWARTESGIFRSVLRA 599 GS PF + +L+A Sbjct: 254 TGSLPFQGKDRKETMALILKA 274
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 116 bits (290), Expect = 7e-26 Identities = 71/194 (36%), Positives = 107/194 (55%), Gaps = 3/194 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ VA+KII++ + + V RE+ L+ L H +++K YD + + +V+E Sbjct: 76 GQKVALKIINRKTLAKSDMQGRVEREISYLRLLR-HPHIIKLYDVIKSKDEIIMVIEFA- 133 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 G EL D I+ RG + E++A+ QI++ V +CH +VHRDLKPEN L D+ + Sbjct: 134 GKELFDYIVQRG-KMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPENLLL---DDQLNV 189 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYV-APEVLHRSY--SMEADIWSIGVITYILLCGSR 548 K+ DFGLS+ + L GS Y+ APEV+ E D+WS GVI Y++LCG Sbjct: 190 KIADFGLSNIMTDGNFLKTSCGSPNYMPAPEVISGKLYAGPEVDVWSAGVILYVMLCGRL 249 Query: 549 PFWARTESGIFRSV 590 PF +F+ + Sbjct: 250 PFDDEFIPALFKKI 263
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 116 bits (290), Expect = 7e-26 Identities = 78/218 (35%), Positives = 118/218 (54%), Gaps = 25/218 (11%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K ++ S++ + REV+I+K L+ H N+VK ++ E +Y++ME Sbjct: 79 GREVAIKIIDKTQLNPT-SLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYAS 136 Query: 198 GGELLDRILARGGRYTEEDAKA-----------IVVQ------------ILSVVAFCHLQ 308 GGE+ D ++A GR E++A++ I VQ I+S V +CH + Sbjct: 137 GGEVFDYLVAH-GRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQK 195 Query: 309 GVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY 485 +VHRDLK EN L D + +K+ DFG S+ +L+ GS Y APE+ + Y Sbjct: 196 RIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKY 252 Query: 486 -SMEADIWSIGVITYILLCGSRPFWARTESGIFRSVLR 596 E D+WS+GVI Y L+ GS PF + + VLR Sbjct: 253 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 290
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 115 bits (289), Expect = 9e-26 Identities = 69/198 (34%), Positives = 114/198 (57%), Gaps = 10/198 (5%) Frame = +3 Query: 3 KGEYKGQT---VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNV 173 +G ++ +T VA+K I+K ++ + + + +E+KILK L H N+V YD E +V Sbjct: 25 RGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQ-HENIVALYDVQELPNSV 81 Query: 174 YIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT 353 ++VME C GG+L D + A+ G +E+ + + QI + + H +G++HRDLKP+N L + Sbjct: 82 FLVMEYCNGGDLADYLQAK-GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLS 140 Query: 354 ---TRDENAP---MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSI 512 R N +K+ DFG + ++ + + GS Y+APEV + + Y +AD+WSI Sbjct: 141 YANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYDAKADLWSI 200 Query: 513 GVITYILLCGSRPFWART 566 G + Y L G PF A + Sbjct: 201 GTVIYQCLVGKPPFQANS 218
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 115 bits (289), Expect = 9e-26 Identities = 69/185 (37%), Positives = 104/185 (56%), Gaps = 7/185 (3%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VAVK I+K + + ++ + +E+KILK L H N+V YD E A +VY+VME C GG+ Sbjct: 43 VAVKCINKKNLAKSQTL--LGKEIKILKELK-HENIVALYDFQEMANSVYLVMEYCNGGD 99 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT------TRDEN 368 L D L +E+ + + QI + H +G++HRDLKP+N L + N Sbjct: 100 LAD-YLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSN 158 Query: 369 APMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGS 545 +K+ DFG + +++ + + GS Y+APEV + + Y +AD+WSIG I Y L G Sbjct: 159 IRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGK 218 Query: 546 RPFWA 560 PF A Sbjct: 219 APFQA 223
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 115 bits (289), Expect = 9e-26 Identities = 71/178 (39%), Positives = 99/178 (55%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I K+K D E++IL H N++ D +D VY+V EL GGEL Sbjct: 462 AVKVIDKSK-------RDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMRGGEL 514 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN-APMKLI 386 LD+IL R ++E +A +++ I V + H QGVVHRDLKP N L+ N +++ Sbjct: 515 LDKIL-RQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRIC 573 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL R Y DIWS+GV+ Y +L G PF Sbjct: 574 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCTPF 631 Score = 97.1 bits (240), Expect = 4e-20 Identities = 63/193 (32%), Positives = 107/193 (55%), Gaps = 3/193 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREV-KILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 A+K++ KA + + VR ++ + + A H +VK + A + +Y++++ GG+ Sbjct: 110 AMKVLKKATLKVR---DRVRTKIERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGD 166 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L R L++ +TEED K + ++ + H G+++RDLKPEN L DE +KL Sbjct: 167 LFTR-LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHIKLT 222 Query: 387 DFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPFWA 560 DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ + +L GS PF Sbjct: 223 DFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQG 282 Query: 561 RTESGIFRSVLRA 599 + +L+A Sbjct: 283 KDRKETMTLILKA 295
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 115 bits (288), Expect = 1e-25 Identities = 72/181 (39%), Positives = 104/181 (57%), Gaps = 2/181 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G AVK+I ++++ E + E+++ + L H ++V+F EDA N+YI +ELC Sbjct: 85 GSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ-HRHIVRFSHHFEDADNIYIFLELCS 143 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 L AR E + + + QILS + + H +G++HRDLK NF T EN + Sbjct: 144 RKSLAHIWKARH-TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT---ENMEL 199 Query: 378 KLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 K+ DFGL+ + P E R I G+ YVAPEVL R + EAD+WS+G + Y LLCGS P Sbjct: 200 KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP 259 Query: 552 F 554 F Sbjct: 260 F 260
>PLK3_CAEEL (Q20845) Serine/threonine-protein kinase plk-3 (EC 2.7.11.21)| (Polo-like kinase 3) Length = 615 Score = 115 bits (288), Expect = 1e-25 Identities = 68/180 (37%), Positives = 106/180 (58%), Gaps = 1/180 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 +AVK++ K + + + E + REV+I + LS H N+V+F+ ED+ NVY +ELC Sbjct: 61 LAVKVVPKVILLKSTAREKLTREVEIHRQLS-HRNIVQFHHFFEDSQNVYFTLELCSKNS 119 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L++ RG TE +A+ +Q+ V H ++HRDLK N +E+ +K+ Sbjct: 120 LMELNKQRGP-LTEHEARFYTIQVAEGVKHLHNLQIIHRDLKLGNLFL---NEHLQVKIG 175 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFWAR 563 DFGL+ F +E+ G+ Y+APEVL+ + ++ E DIW+IG I Y+LL GS PF +R Sbjct: 176 DFGLATFCEKNEKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGCILYVLLFGSPPFESR 235
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1) (Ribosomal| protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 115 bits (288), Expect = 1e-25 Identities = 76/212 (35%), Positives = 109/212 (51%), Gaps = 6/212 (2%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I K K D E++IL+ H N++ D ++ ++Y+V EL GGEL Sbjct: 443 AVKVIDKTK-------RDPSEEIEILRRYGQHPNIIALKDVYKEGNSIYVVTELMRGGEL 495 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD-ENAPMKLI 386 LDRIL R ++E +A +++ + V H QGVVHRDLKP N L+ + +++ Sbjct: 496 LDRIL-RQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKPSNILYVDESGDPESIRIC 554 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF-- 554 DFG + +R D L +A +VAPEVL R Y DIWS+G++ Y +L G PF Sbjct: 555 DFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN 614 Query: 555 -WARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 T I + L W +VSA A Sbjct: 615 GLGDTPEEILARIGSGKFTLRGGNWNTVSAAA 646 Score = 96.7 bits (239), Expect = 5e-20 Identities = 63/195 (32%), Positives = 106/195 (54%), Gaps = 2/195 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q A+K++ KA + + + E IL + H +V+ + A + +Y++++ G Sbjct: 89 QLYAMKVLKKATLKVRDRVR-TKMERDILADVH-HPFVVRLHYAFQTEGKLYLILDFLRG 146 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE +K Sbjct: 147 GDLFTR-LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHIK 202 Query: 381 LIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 L DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ + +L GS PF Sbjct: 203 LTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPF 262 Query: 555 WARTESGIFRSVLRA 599 + +L+A Sbjct: 263 QGKDRKETMTLILKA 277
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 115 bits (288), Expect = 1e-25 Identities = 75/185 (40%), Positives = 109/185 (58%), Gaps = 6/185 (3%) Frame = +3 Query: 18 GQTVAVKIISK--AKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 G+ VA+K+I K AK T ++ +++RRE +I + + H N+ + D E + Y+VMEL Sbjct: 85 GEKVAIKVIDKKRAKKDTYVT-KNLRREGQIQQMIR-HPNITQLLDILETENSYYLVMEL 142 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GG L+ +I + R E +A+ + Q++S V H GVVHRDLK EN L DE+ Sbjct: 143 CPGGNLMHKIYEK-KRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLL---DEDN 198 Query: 372 PMKLIDFGLSD---FIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLC 539 +KLIDFGLS+ + + + GS Y APE+L R Y + D+WSIGV Y +L Sbjct: 199 NIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLT 258 Query: 540 GSRPF 554 G+ PF Sbjct: 259 GTLPF 263
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 115 bits (288), Expect = 1e-25 Identities = 75/185 (40%), Positives = 109/185 (58%), Gaps = 6/185 (3%) Frame = +3 Query: 18 GQTVAVKIISK--AKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 G+ VA+K+I K AK T ++ +++RRE +I + + H N+ + D E + Y+VMEL Sbjct: 85 GEKVAIKVIDKKRAKKDTYVT-KNLRREGQIQQMIR-HPNITQLLDILETENSYYLVMEL 142 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GG L+ +I + R E +A+ + Q++S V H GVVHRDLK EN L DE+ Sbjct: 143 CPGGNLMHKIYEK-KRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLL---DEDN 198 Query: 372 PMKLIDFGLSD---FIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLC 539 +KLIDFGLS+ + + + GS Y APE+L R Y + D+WSIGV Y +L Sbjct: 199 NIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLT 258 Query: 540 GSRPF 554 G+ PF Sbjct: 259 GTLPF 263
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 115 bits (287), Expect = 1e-25 Identities = 70/178 (39%), Positives = 99/178 (55%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I K+K D E++IL H N++ D +D +VY+V EL GGEL Sbjct: 434 AVKVIDKSK-------RDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 486 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP-MKLI 386 LD+IL R ++E +A ++ I V + H QGVVHRDLKP N L+ N +++ Sbjct: 487 LDKIL-RQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 545 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL R Y DIWS+G++ Y +L G PF Sbjct: 546 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF 603 Score = 85.9 bits (211), Expect = 9e-17 Identities = 56/170 (32%), Positives = 95/170 (55%), Gaps = 2/170 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A+K++ KA + + + E IL ++ H +VK + A + +Y++++ Sbjct: 88 GHLYAMKVLKKATLKVRDRVR-TKMERDILADVN-HPFVVKLHYAFQTEGKLYLILDFLR 145 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE + Sbjct: 146 GGDLFTR-LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHI 201 Query: 378 KLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVI 521 KL DFGLS + I +++ G+ Y+APEV++R ++ AD WS GV+ Sbjct: 202 KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVL 251
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 115 bits (287), Expect = 1e-25 Identities = 70/207 (33%), Positives = 112/207 (54%), Gaps = 14/207 (6%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+T AVKIISK K+ +++ V RE+++L+ L+ H +V+ ED + Y+VME Sbjct: 221 GKTFAVKIISKRKVIG--NMDGVTRELEVLQKLN-HPRIVRLKGFYEDTESYYMVMEFVS 277 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG+L+D + A G E+ + I QIL+ + + H G+ HRDLKP+N L +D+ + Sbjct: 278 GGDLMDFVAAHGA-VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILI-EQDDPVLV 335 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--------------HRSYSMEADIWSIG 515 K+ DFGL+ + G+ YVAPEV+ YS D+WS+G Sbjct: 336 KITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMG 395 Query: 516 VITYILLCGSRPFWARTESGIFRSVLR 596 + Y++L G PF T+ +++ + R Sbjct: 396 CLVYVILTGHLPFSGSTQDQLYKQIGR 422
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 115 bits (287), Expect = 1e-25 Identities = 67/198 (33%), Positives = 113/198 (57%), Gaps = 10/198 (5%) Frame = +3 Query: 3 KGEYKGQT---VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNV 173 +G ++ +T VA+K I+K ++ + + + +E+KILK L H N+V YD E +V Sbjct: 25 RGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQ-HENIVALYDVQELPNSV 81 Query: 174 YIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT 353 ++VME C GG+L D + A+ G +E+ + + QI + + H +G++HRDLKP+N L + Sbjct: 82 FLVMEYCNGGDLADYLQAK-GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLS 140 Query: 354 TRDENAP------MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSI 512 + +K+ DFG + ++ + + GS Y+APEV + + Y +AD+WSI Sbjct: 141 YANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSI 200 Query: 513 GVITYILLCGSRPFWART 566 G + Y L G PF A + Sbjct: 201 GTVIYQCLVGKPPFQANS 218
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 115 bits (287), Expect = 1e-25 Identities = 75/185 (40%), Positives = 109/185 (58%), Gaps = 6/185 (3%) Frame = +3 Query: 18 GQTVAVKIISK--AKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 G+ VA+K+I K AK T ++ +++RRE +I + + H N+ + D E + Y+VMEL Sbjct: 85 GEKVAIKVIDKKRAKKDTYVT-KNLRREGQIQQMIR-HPNITQLLDILETENSYYLVMEL 142 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GG L+ +I + R E +A+ + Q++S V H GVVHRDLK EN L DE+ Sbjct: 143 CPGGNLMHKIYEK-KRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKIENLLL---DEDN 198 Query: 372 PMKLIDFGLSD---FIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLC 539 +KLIDFGLS+ + + + GS Y APE+L R Y + D+WSIGV Y +L Sbjct: 199 NIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLT 258 Query: 540 GSRPF 554 G+ PF Sbjct: 259 GTLPF 263
>MAPK3_HUMAN (Q16644) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK) Length = 382 Score = 115 bits (287), Expect = 1e-25 Identities = 73/197 (37%), Positives = 105/197 (53%), Gaps = 10/197 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 R+EV SG ++V D E+ + + I+ME EGGEL RI RG + +TE Sbjct: 82 RQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTER 141 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + F H + HRD+KPEN L+T+++++A +KL DFG + L Sbjct: 142 EAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQ 200 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWART----ESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ T G+ R + Sbjct: 201 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 260 Query: 597 ADPNLDDSPWPSVSAEA 647 + W VS +A Sbjct: 261 GQYGFPNPEWSEVSEDA 277
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 114 bits (286), Expect = 2e-25 Identities = 68/185 (36%), Positives = 105/185 (56%), Gaps = 7/185 (3%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VAVK I+K + + ++ + +E+KILK L H N+V YD E A +VY+VME C GG+ Sbjct: 43 VAVKCINKKNLAKSQTL--LGKEIKILKELK-HENIVALYDFQEMANSVYLVMEYCNGGD 99 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFT------TRDEN 368 L D + A +E+ + + QI + H +G++HRDLKP+N L + + Sbjct: 100 LADYLHAM-RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNS 158 Query: 369 APMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGS 545 +K+ DFG + +++ + + GS Y+APEV + + Y +AD+WSIG I Y L G Sbjct: 159 IRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGK 218 Query: 546 RPFWA 560 PF A Sbjct: 219 APFQA 223
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 114 bits (285), Expect = 2e-25 Identities = 69/199 (34%), Positives = 112/199 (56%), Gaps = 2/199 (1%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G VA+K+I K M A ++ V+ EVKI L H ++++ Y+ ED VY+V+E+ Sbjct: 33 HTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK-HPSVLELYNYFEDNNYVYLVLEM 91 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GE+ + R ++E +A+ + QI++ + + H G++HRDL N L T N Sbjct: 92 CHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNM 148 Query: 372 PMKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGS 545 +K+ DFGL+ + P E+ + G+ Y++PE+ RS + +E+DIWS+G + Y LL G Sbjct: 149 NIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGR 208 Query: 546 RPFWARTESGIFRSVLRAD 602 PF T V+ AD Sbjct: 209 PPFDTDTVKNTLNKVVLAD 227
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 114 bits (285), Expect = 2e-25 Identities = 70/178 (39%), Positives = 99/178 (55%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I K+K D E++IL H N++ D +D +VY+V EL GGEL Sbjct: 445 AVKVIDKSK-------RDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 497 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP-MKLI 386 LD+IL R ++E +A ++ I V + H QGVVHRDLKP N L+ N +++ Sbjct: 498 LDKIL-RQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 556 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL R Y DIWS+G++ Y +L G PF Sbjct: 557 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF 614 Score = 99.0 bits (245), Expect = 1e-20 Identities = 64/196 (32%), Positives = 107/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A+K++ KA + + + E IL ++ H +VK + A + +Y++++ Sbjct: 88 GHLYAMKVLKKATLKVRDRVR-TKMERDILADVN-HPFVVKLHYAFQTEGKLYLILDFLR 145 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG+L R L++ +TEED K + ++ + H G+++RDLKPEN L DE + Sbjct: 146 GGDLFTR-LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHI 201 Query: 378 KLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRP 551 KL DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ + +L GS P Sbjct: 202 KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLP 261 Query: 552 FWARTESGIFRSVLRA 599 F + +L+A Sbjct: 262 FQGKDRKETMTLILKA 277
>CSKP_HUMAN (O14936) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 114 bits (284), Expect = 3e-25 Identities = 70/217 (32%), Positives = 117/217 (53%), Gaps = 7/217 (3%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA--ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 GQ AVKI+ AK T++ +S ED++RE I L H ++V+ + +Y+V E Sbjct: 35 GQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK-HPHIVELLETYSSDGMLYMVFEF 93 Query: 192 CEGGELLDRILAR---GGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +G +L I+ R G Y+E A + QIL + +CH ++HRD+KP L +++ Sbjct: 94 MDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKE 153 Query: 363 ENAPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILL 536 +AP+KL FG++ + + VG+ +++APEV+ R Y D+W GVI +ILL Sbjct: 154 NSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILL 213 Query: 537 CGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF+ T+ +F +++ ++ W +S A Sbjct: 214 SGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESA 249
>CSKP_MOUSE (O70589) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 924 Score = 114 bits (284), Expect = 3e-25 Identities = 70/217 (32%), Positives = 117/217 (53%), Gaps = 7/217 (3%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA--ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 GQ AVKI+ AK T++ +S ED++RE I L H ++V+ + +Y+V E Sbjct: 35 GQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK-HPHIVELLETYSSDGMLYMVFEF 93 Query: 192 CEGGELLDRILAR---GGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +G +L I+ R G Y+E A + QIL + +CH ++HRD+KP L +++ Sbjct: 94 MDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKE 153 Query: 363 ENAPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILL 536 +AP+KL FG++ + + VG+ +++APEV+ R Y D+W GVI +ILL Sbjct: 154 NSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILL 213 Query: 537 CGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF+ T+ +F +++ ++ W +S A Sbjct: 214 SGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESA 249
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)| Length = 878 Score = 114 bits (284), Expect = 3e-25 Identities = 77/212 (36%), Positives = 112/212 (52%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VAVK+I K + T + +R EV IL++L H +V E V++VME Sbjct: 574 GRDVAVKVIDKLRFPTKQESQ-LRNEVAILQSLR-HPGIVNLECMFETPEKVFVVMEKLH 631 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 G ++L+ IL+ GR E K ++ QIL + H + +VH DLKPEN L + D Sbjct: 632 G-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQ 690 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSRP 551 +KL DFG + I +VG+ Y+APEV L++ Y+ D+WS+GVI Y+ L G+ P Sbjct: 691 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFP 750 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + I + A SPW +SA A Sbjct: 751 F--NEDEDINDQIQNAAFMYPASPWSHISAGA 780
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 114 bits (284), Expect = 3e-25 Identities = 75/201 (37%), Positives = 110/201 (54%), Gaps = 13/201 (6%) Frame = +3 Query: 3 KGEYKGQT---VAVKIISKAKMTTAISIEDVRREVKILKALSG--HNNLVKFYDACEDAL 167 +G Y +T VA+K I+K ++ + ++ + +E+KILK LS H NLV E Sbjct: 25 RGRYVDRTDVPVAIKAIAKKNISKSKNL--LTKEIKILKELSSLKHENLVGLLKCTETPT 82 Query: 168 NVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFL 347 +VY+VME C GG+L D L + E+ + VVQI + + +G+VHRDLKP+N L Sbjct: 83 HVYLVMEFCNGGDLAD-YLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRDLKPQNIL 141 Query: 348 F--TTRDENAP-----MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADI 503 +R +N +KL DFG + F+ + GS Y+APEV+ Y +AD+ Sbjct: 142 LCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADL 201 Query: 504 WSIGVITYILLCGSRPFWART 566 WSIG I + L G PF A+T Sbjct: 202 WSIGTILFQCLTGKAPFVAQT 222
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 114 bits (284), Expect = 3e-25 Identities = 76/212 (35%), Positives = 111/212 (52%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K + T + +R EV IL+ L H +V E V++VME Sbjct: 606 GRDVAIKIIDKLRFPTKQESQ-LRNEVAILQNLH-HPGVVNLECMFETPERVFVVMEKLH 663 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 G ++L+ IL+ GR E K ++ QIL + H + +VH DLKPEN L + D Sbjct: 664 G-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQ 722 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRP 551 +KL DFG + I +VG+ Y+APEVL ++ Y+ D+WS+GVI Y+ L G+ P Sbjct: 723 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFP 782 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + I + A +PW +S EA Sbjct: 783 F--NEDEDIHDQIQNAAFMYPPNPWKEISHEA 812
>CSKP_RAT (Q62915) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 909 Score = 114 bits (284), Expect = 3e-25 Identities = 70/217 (32%), Positives = 117/217 (53%), Gaps = 7/217 (3%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA--ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 GQ AVKI+ AK T++ +S ED++RE I L H ++V+ + +Y+V E Sbjct: 35 GQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK-HPHIVELLETYSSDGMLYMVFEF 93 Query: 192 CEGGELLDRILAR---GGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +G +L I+ R G Y+E A + QIL + +CH ++HRD+KP L +++ Sbjct: 94 MDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKE 153 Query: 363 ENAPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILL 536 +AP+KL FG++ + + VG+ +++APEV+ R Y D+W GVI +ILL Sbjct: 154 NSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILL 213 Query: 537 CGSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G PF+ T+ +F +++ ++ W +S A Sbjct: 214 SGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESA 249
>MKNK1_MOUSE (O08605) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 427 Score = 113 bits (282), Expect = 6e-25 Identities = 76/239 (31%), Positives = 113/239 (47%), Gaps = 29/239 (12%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ AVKII K S V REV+ L G+ N+++ + ED Y+V E + Sbjct: 72 GKEYAVKIIEKQ---AGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQ 128 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG +L I R + E +A +V + + + F H +G+ HRDLKPEN L + ++ +P+ Sbjct: 129 GGSILAHIQKRK-HFNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPV 187 Query: 378 KLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSMEADIWSIG 515 K+ DF L ++ + I GSA Y+APEV+ Y D+WS+G Sbjct: 188 KICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLG 247 Query: 516 VITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 V+ YI+L G PF W R E + +F S+ D W +S EA Sbjct: 248 VVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEA 306
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 113 bits (282), Expect = 6e-25 Identities = 71/178 (39%), Positives = 100/178 (56%), Gaps = 3/178 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVKII K+K D E++IL H N++ D +D VY+V +L +GGEL Sbjct: 453 AVKIIDKSK-------RDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGEL 505 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA-PMKLI 386 LDRIL + ++E +A I+ I V + H QGVVHRDLKP N L+ +A +++ Sbjct: 506 LDRIL-KQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRIC 564 Query: 387 DFGLSDFIRPDE-RLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPF 554 DFG + +R + L +A +VAPEVL + Y DIWS+GV+ Y +L G PF Sbjct: 565 DFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPF 622 Score = 101 bits (252), Expect = 2e-21 Identities = 64/200 (32%), Positives = 110/200 (55%), Gaps = 2/200 (1%) Frame = +3 Query: 6 GEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVM 185 G GQ A+K++ KA + + + E IL ++ H +VK + A + +Y+++ Sbjct: 95 GPDAGQLYAMKVLKKASLKVRDRVR-TKMERDILVEVN-HPFIVKLHYAFQTEGKLYLIL 152 Query: 186 ELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDE 365 + GG++ R L++ +TEED K + ++ + H G+V+RDLKPEN L DE Sbjct: 153 DFLRGGDVFTR-LSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILL---DE 208 Query: 366 NAPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLC 539 +KL DFGLS + + +++ G+ Y+APEV++ R +S AD WS GV+ + +L Sbjct: 209 IGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT 268 Query: 540 GSRPFWARTESGIFRSVLRA 599 G+ PF + + +L+A Sbjct: 269 GTLPFQGKDRNETMNMILKA 288
>PLK3_MOUSE (Q60806) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) Length = 631 Score = 113 bits (282), Expect = 6e-25 Identities = 71/181 (39%), Positives = 104/181 (57%), Gaps = 2/181 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G AVK+I ++++ E + E+++ + L H ++V+F EDA N+YI +ELC Sbjct: 86 GIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ-HRHIVRFSHHFEDADNIYIFLELCS 144 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 L AR E + + + QILS + + H +G++HRDLK NF T +N + Sbjct: 145 RKSLAHIWKARH-TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT---DNMEL 200 Query: 378 KLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRP 551 K+ DFGL+ + P E R I G+ YVAPEVL R + EAD+WS+G + Y LLCGS P Sbjct: 201 KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP 260 Query: 552 F 554 F Sbjct: 261 F 261
>MAPK2_HUMAN (P49137) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 400 Score = 112 bits (281), Expect = 7e-25 Identities = 71/196 (36%), Positives = 100/196 (51%), Gaps = 10/196 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 RREV++ S ++V+ D E+ + IVME +GGEL RI RG + +TE Sbjct: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + H + HRD+KPEN L+T++ NA +KL DFG + L Sbjct: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR----TESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ G+ + Sbjct: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 Query: 597 ADPNLDDSPWPSVSAE 644 + W VS E Sbjct: 282 GQYEFPNPEWSEVSEE 297
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 112 bits (281), Expect = 7e-25 Identities = 72/184 (39%), Positives = 105/184 (57%), Gaps = 6/184 (3%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISI-EDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 + VAVKI+ M AI E++++E+ I K LS H N+VKFY + Y+ +E C Sbjct: 33 EAVAVKIVD---MKRAIDCPENIKKEICINKMLS-HENVVKFYGHRREGHIQYLFLEYCS 88 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI G E+DA+ Q+++ V + H G+ HRD+KPEN L RD + Sbjct: 89 GGELFDRIEPDIGM-PEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN---L 144 Query: 378 KLIDFGLSDFIRPDER---LNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYILLCG 542 K+ DFGL+ R + R LN + G+ YVAPE+L R ++ D+WS G++ +L G Sbjct: 145 KISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAG 204 Query: 543 SRPF 554 P+ Sbjct: 205 ELPW 208
>PLK1_CAEEL (P34331) Serine/threonine-protein kinase plk-1 (EC 2.7.11.21)| (Polo-like kinase 1) Length = 649 Score = 112 bits (281), Expect = 7e-25 Identities = 64/183 (34%), Positives = 105/183 (57%), Gaps = 1/183 (0%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 + VA K++ K+ + + V E ++ GH N+VK ++ ED LNVYI +ELC Sbjct: 62 EVVAGKVVPKSMLVKQYQRDKVDNERILIHRELGHINIVKLFNFFEDNLNVYITLELCAR 121 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 L++ + R TE +A+ QI+ V + H ++HRD+K N +++ +K Sbjct: 122 RSLME-LHKRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFL---NDDLVVK 177 Query: 381 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPFW 557 + DFGL+ + DER + G+ Y+APEVL+++ +S E DIW++G I YILL G PF Sbjct: 178 IGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFE 237 Query: 558 ART 566 +++ Sbjct: 238 SKS 240
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 112 bits (281), Expect = 7e-25 Identities = 72/197 (36%), Positives = 111/197 (56%), Gaps = 12/197 (6%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAIS----IEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVM 185 G+ A+KII+K K+ S E +RE+ ILK+L H +V+ ++ E+ ++IVM Sbjct: 190 GKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLH-HPGVVQCHEIFENDDELFIVM 248 Query: 186 ELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDE 365 E EGG+L+D ++A G E+D K ++ Q+L + H QGV HRD+KPEN L T Sbjct: 249 EYVEGGDLMDFLIANGS-IDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILIT---N 304 Query: 366 NAPMKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHR-------SYSMEADIWSIGVI 521 + +K+ DFGL+ I L G+ Y+APEVL Y + DIWS+G + Sbjct: 305 DFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCV 364 Query: 522 TYILLCGSRPFWARTES 572 Y++L S PF + +++ Sbjct: 365 LYVMLTASIPFASSSQA 381
>MKNK1_RAT (Q4G050) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 413 Score = 112 bits (281), Expect = 7e-25 Identities = 76/239 (31%), Positives = 113/239 (47%), Gaps = 29/239 (12%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ AVKII K S V REV+ L G+ N+++ + ED Y+V E + Sbjct: 60 GKEYAVKIIEKQ---AGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQ 116 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG +L I R + E +A +V + + + F H +G+ HRDLKPEN L + ++ +P+ Sbjct: 117 GGSILAHIQKRK-HFNELEASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPV 175 Query: 378 KLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSMEADIWSIG 515 K+ DF L ++ + I GSA Y+APEV+ Y D+WS+G Sbjct: 176 KICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLG 235 Query: 516 VITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 V+ YI+L G PF W R E + +F S+ D W +S EA Sbjct: 236 VVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISTEA 294
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 112 bits (279), Expect = 1e-24 Identities = 70/177 (39%), Positives = 103/177 (58%), Gaps = 2/177 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 AVK+I ++++ E + E+++ + L H ++V+F EDA N+YI +ELC L Sbjct: 58 AVKVIPQSRVAKPHQREKIINEIELHRDLQ-HRHIVRFSHHFEDADNIYIFLELCSRKSL 116 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 AR E + + + QILS + + H +G++HRDLK NF T +N +K+ D Sbjct: 117 AHIWKARH-TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT---DNMELKVGD 172 Query: 390 FGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSMEADIWSIGVITYILLCGSRPF 554 FGL+ + P E R I G+ YVAPEVL R + EAD+WS+G + Y LLCGS PF Sbjct: 173 FGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPF 229
>TSSK3_MOUSE (Q9D2E1) Testis-specific serine/threonine-protein kinase 3 (EC| 2.7.11.1) (TSSK-3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C) Length = 268 Score = 112 bits (279), Expect = 1e-24 Identities = 70/181 (38%), Positives = 100/181 (55%), Gaps = 5/181 (2%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALN-VYIVMELCEGG 203 VA+KII K + RE++I++ L H N+++ Y+ E A +Y+VMEL EGG Sbjct: 36 VAIKIIDKMGGPEEFIQRFLPRELQIVRTLD-HKNIIQVYEMLESADGKIYLVMELAEGG 94 Query: 204 ELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKL 383 ++ D +L GG E AKA+ Q++ + +CH GV HRDLK EN L + +KL Sbjct: 95 DVFDCVL-NGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALL----QGFNLKL 149 Query: 384 IDFGLSDFIRPDER--LNDIVGSAYYVAPEVLH--RSYSMEADIWSIGVITYILLCGSRP 551 DFG + + R GS Y APEVL S + D+WS+GV+ Y++LC S P Sbjct: 150 TDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLP 209 Query: 552 F 554 F Sbjct: 210 F 210
>MAPK2_CRILO (P49136) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (P45-54 HSP27 kinase) (Fragment) Length = 329 Score = 111 bits (278), Expect = 2e-24 Identities = 71/196 (36%), Positives = 99/196 (50%), Gaps = 10/196 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 RREV++ S ++V D E+ + IVME +GGEL RI RG + +TE Sbjct: 31 RREVELHWRASQCPHIVDIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 90 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + H + HRD+KPEN L+T++ NA +KL DFG + L Sbjct: 91 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 150 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR----TESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ G+ + Sbjct: 151 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 210 Query: 597 ADPNLDDSPWPSVSAE 644 + W VS E Sbjct: 211 GQYEFPNPEWSEVSEE 226
>MAPK2_MOUSE (P49138) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 386 Score = 111 bits (278), Expect = 2e-24 Identities = 71/196 (36%), Positives = 99/196 (50%), Gaps = 10/196 (5%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 RREV++ S ++V D E+ + IVME +GGEL RI RG + +TE Sbjct: 88 RREVELHWRASQCPHIVHIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 147 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + H + HRD+KPEN L+T++ NA +KL DFG + L Sbjct: 148 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 207 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR----TESGIFRSVLR 596 + YYVAPEVL Y D+WS+GVI YILLCG PF++ G+ + Sbjct: 208 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 267 Query: 597 ADPNLDDSPWPSVSAE 644 + W VS E Sbjct: 268 GQYEFPNPEWSEVSEE 283
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 111 bits (278), Expect = 2e-24 Identities = 71/184 (38%), Positives = 105/184 (57%), Gaps = 6/184 (3%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISI-EDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 + VAVKI+ M AI E++++E+ I K L+ H N+VKFY + Y+ +E C Sbjct: 33 EAVAVKIVD---MKRAIDCPENIKKEICINKMLN-HENVVKFYGHRREGNIQYLFLEYCS 88 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI G E+DA+ Q+++ V + H G+ HRD+KPEN L RD + Sbjct: 89 GGELFDRIEPDIGM-PEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN---L 144 Query: 378 KLIDFGLSDFIRPDER---LNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYILLCG 542 K+ DFGL+ R + R LN + G+ YVAPE+L R ++ D+WS G++ +L G Sbjct: 145 KISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAG 204 Query: 543 SRPF 554 P+ Sbjct: 205 ELPW 208
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 111 bits (277), Expect = 2e-24 Identities = 76/208 (36%), Positives = 109/208 (52%), Gaps = 16/208 (7%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTA----ISIED----------VRREVKILKALSGHNNLVKFYDAC 155 GQ AVK+ISKA T SI + RE+ I+K L+ H N+++ YD Sbjct: 42 GQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLN-HPNVLRLYDVW 100 Query: 156 EDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKP 335 E ++Y+V+E E GEL + ++ RG E +A QI+ V++CH G+VHRDLKP Sbjct: 101 ETNTDLYLVLEYAEKGELFNLLVERGP-LPEHEAIRFFRQIIIGVSYCHALGIVHRDLKP 159 Query: 336 ENFLFTTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH--RSYSMEADIWS 509 EN L D +K+ DFG++ + L GS +Y APE++ +D+WS Sbjct: 160 ENLLL---DHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWS 216 Query: 510 IGVITYILLCGSRPFWARTESGIFRSVL 593 GVI + LL G PF E G R++L Sbjct: 217 CGVILFALLTGRLPF--DEEDGNIRTLL 242
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 110 bits (276), Expect = 3e-24 Identities = 75/212 (35%), Positives = 110/212 (51%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+KII K + T + +R EV IL+ L H +V E V++VME Sbjct: 612 GRDVAIKIIDKLRFPTKQESQ-LRNEVAILQNLH-HPGVVNLECMFETPERVFVVMEKLH 669 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 G ++L+ IL+ G E K ++ QIL + H + +VH DLKPEN L + D Sbjct: 670 G-DMLEMILSSEKGWLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQ 728 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRP 551 +KL DFG + I +VG+ Y+APEVL ++ Y+ D+WS+GVI Y+ L G+ P Sbjct: 729 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFP 788 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + I + A +PW +S EA Sbjct: 789 F--NEDEDIHDQIQNAAFMYPPNPWKEISHEA 818
>PLK2_CAEEL (Q9N2L7) Serine/threonine-protein kinase plk-2 (EC 2.7.11.21)| (Polo-like kinase 2) Length = 632 Score = 110 bits (276), Expect = 3e-24 Identities = 68/184 (36%), Positives = 103/184 (55%), Gaps = 1/184 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ A K++ KA + + + +EV+I + L H N+VK Y ED NVYI +ELC Sbjct: 59 GELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQ-HRNVVKLYHFFEDKSNVYITLELCP 117 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 L++ + R TE +A+ QI+ V + H +VHRDLK N ++ + Sbjct: 118 RRSLME-LHKRRKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFL---NDELQV 173 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSMEADIWSIGVITYILLCGSRPF 554 K+ DFGL+ DER + G+ Y+APEVL++ +S E D+W+IG I YILL G PF Sbjct: 174 KIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPF 233 Query: 555 WART 566 +++ Sbjct: 234 ESKS 237
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 109 bits (273), Expect = 6e-24 Identities = 68/183 (37%), Positives = 102/183 (55%), Gaps = 5/183 (2%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 + VAVKI+ + A E++++E+ I K L+ H N+VKFY + Y+ +E C G Sbjct: 33 EAVAVKIVDMKR--AADCPENIKKEICINKMLN-HENVVKFYGHRREGATQYLFLEYCSG 89 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL DRI G E +A+ Q+++ V + H G+ HRDLKPEN L RD +K Sbjct: 90 GELFDRIEPDIGM-PEPEAQRFFQQLIAGVVYLHSMGITHRDLKPENLLLDERDN---LK 145 Query: 381 LIDFGLSDFIRPDER---LNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYILLCGS 545 + DFGL+ + + R LN + G+ YVAPE+L R + D+W+ GV+ +L G Sbjct: 146 ISDFGLATVFKHNGRERLLNKMCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAGE 205 Query: 546 RPF 554 P+ Sbjct: 206 LPW 208
>TSSK1_MOUSE (Q61241) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 364 Score = 109 bits (273), Expect = 6e-24 Identities = 81/185 (43%), Positives = 107/185 (57%), Gaps = 9/185 (4%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYD--ACEDALNVYIVMELCEG 200 VAVKII + K + + + RE++IL A+ H ++VK Y+ A D VYIVMEL Sbjct: 38 VAVKIIDRKKAPSDFLEKFLPREIEIL-AMLNHRSIVKTYEIFATSDG-KVYIVMELGVQ 95 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G+LL+ I RG E+DA+ Q+ S + +CH VVHRDLK EN L D++ +K Sbjct: 96 GDLLEFIKTRGA-LQEDDARKKFHQLSSAIKYCHDLDVVHRDLKSENLLL---DKDFNIK 151 Query: 381 LIDFGLSDFIRPDE--RL---NDIVGSAYYVAPEVLHR-SYSMEA-DIWSIGVITYILLC 539 L DFG S D+ RL GSA Y APEVL Y + DIWS+GVI YI++C Sbjct: 152 LSDFGFSKRCLRDDSGRLILSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVC 211 Query: 540 GSRPF 554 GS P+ Sbjct: 212 GSMPY 216
>MKNK1_BOVIN (Q58D94) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 420 Score = 109 bits (272), Expect = 8e-24 Identities = 74/239 (30%), Positives = 113/239 (47%), Gaps = 29/239 (12%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G AVKII K S V REV+ L G+ ++++ + ED Y+V E + Sbjct: 60 GNEYAVKIIEKH---AGHSRSRVFREVETLYQCQGNKHILELIEFFEDDTRFYLVFEKLQ 116 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG +L I + + E +A +V + + + F H +G+ HRDLKPEN L + ++ +P+ Sbjct: 117 GGSILAHI-QKQKHFNEREASRVVRDVAAALDFRHTKGIAHRDLKPENILCESPEKVSPV 175 Query: 378 KLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSMEADIWSIG 515 K+ DF L ++ + I GSA Y+APEV+ Y D+WS+G Sbjct: 176 KICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDEATFYDKRCDLWSLG 235 Query: 516 VITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 V+ YI+L G PF W R E + +F S+ + D W +S EA Sbjct: 236 VVLYIMLSGYPPFVGHCGADCGWDRGEVCTVCQNKLFESIQKGKYEFPDKDWAHISNEA 294
>MAPK5_HUMAN (Q8IW41) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase) Length = 473 Score = 109 bits (272), Expect = 8e-24 Identities = 73/243 (30%), Positives = 116/243 (47%), Gaps = 36/243 (14%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIE--DVRREVKILKALSGHNNLVKFYDACEDALN---------- 170 V VK ++ + I ++ R EV++ + H N+V+ + +++ Sbjct: 38 VCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRAR 97 Query: 171 VYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLF 350 + IVME+ EGGEL RI ++ +TE+ A + QI + CHL + HRDLKPEN LF Sbjct: 98 LLIVMEMMEGGELFHRI-SQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLF 156 Query: 351 TTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR----------------- 479 +AP+KL DFG + + D L + YYVAP+VL Sbjct: 157 KDNSLDAPVKLCDFGFAKIDQGD--LMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPT 214 Query: 480 --SYSMEADIWSIGVITYILLCGSRPFWARTES-----GIFRSVLRADPNLDDSPWPSVS 638 +Y+ D+WS+GVI Y++LCG PF+++ S + R ++ + W +S Sbjct: 215 PYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQIS 274 Query: 639 AEA 647 A Sbjct: 275 EMA 277
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 109 bits (272), Expect = 8e-24 Identities = 70/184 (38%), Positives = 104/184 (56%), Gaps = 6/184 (3%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISI-EDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 + VAVKI+ M A+ E++++E+ I K L+ H N+VKFY + Y+ +E C Sbjct: 33 EAVAVKIVD---MKRAVDCPENIKKEICINKMLN-HENVVKFYGHRREGNIQYLFLEYCS 88 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GGEL DRI G E DA+ Q+++ V + H G+ HRD+KPEN L RD + Sbjct: 89 GGELFDRIEPDIGM-PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN---L 144 Query: 378 KLIDFGLSDFIRPDER---LNDIVGSAYYVAPEVLHRS--YSMEADIWSIGVITYILLCG 542 K+ DFGL+ R + R LN + G+ YVAPE+L R ++ D+WS G++ +L G Sbjct: 145 KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAG 204 Query: 543 SRPF 554 P+ Sbjct: 205 ELPW 208
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 109 bits (272), Expect = 8e-24 Identities = 74/212 (34%), Positives = 110/212 (51%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+K+I K + T + +R EV IL+ L H +V E V++VME Sbjct: 598 GRDVAIKVIDKMRFPTKQESQ-LRNEVAILQNLH-HPGIVNLECMFETPERVFVVMEKLH 655 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 G ++L+ IL+ R E K +V QIL + H + +VH DLKPEN L + + Sbjct: 656 G-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQ 714 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRP 551 +KL DFG + I +VG+ Y+APEVL + Y+ D+WS+GVI Y+ L G+ P Sbjct: 715 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFP 774 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + I + A +PW +S+EA Sbjct: 775 F--NEDEDINDQIQNAAFMYPPNPWREISSEA 804
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 109 bits (272), Expect = 8e-24 Identities = 72/212 (33%), Positives = 114/212 (53%), Gaps = 5/212 (2%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 + VAVKI+ + A E++++E+ I + LS H N+V+FY + Y+ +E C G Sbjct: 33 EAVAVKIVDMTR--AADCPENIKKEICINRMLS-HTNIVRFYGHRREGNIQYLFLEYCRG 89 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL DRI G E+DA+ Q+++ V + H G+ HRD+KPEN L RD+ +K Sbjct: 90 GELFDRIEPDVGM-PEQDAQKFFQQLIAGVEYLHSIGITHRDIKPENLLLDERDQ---LK 145 Query: 381 LIDFGLSDFIR---PDERLNDIVGSAYYVAPEVL-HRSYSME-ADIWSIGVITYILLCGS 545 + DFGL+ R + LN + G+ YVAPE++ R++ + D+WS G++ +L G Sbjct: 146 ISDFGLATVFRHNGKERLLNKMCGTLPYVAPELIKSRAFHADPVDVWSCGIVLTAMLAGE 205 Query: 546 RPFWARTESGIFRSVLRADPNLDDSPWPSVSA 641 P W + + N +PW +SA Sbjct: 206 LP-WDQPNEVCQEYCDWKEKNHYLTPWKKISA 236
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 108 bits (271), Expect = 1e-23 Identities = 71/206 (34%), Positives = 107/206 (51%), Gaps = 22/206 (10%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDA-----CEDAL 167 K + GQ VAVKI + + R E IL + H N+V D+ + + Sbjct: 218 KNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQ-HPNIVNLLDSFVEPISKSQI 276 Query: 168 NVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFL 347 Y+V+E + GEL +RI+ R ++++KA+ Q+L+ + + H Q ++HRD+KPEN L Sbjct: 277 QKYLVLEKIDDGELFERIV-RKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENIL 335 Query: 348 FT-TRDEN---------------APMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-H 476 TR EN +K+ DFGL+ F + N + G+ YVAPEVL Sbjct: 336 LNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTK 395 Query: 477 RSYSMEADIWSIGVITYILLCGSRPF 554 + Y+ + D+WS GVI Y+ LCG PF Sbjct: 396 KGYTSKVDLWSAGVILYVCLCGFPPF 421
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 108 bits (271), Expect = 1e-23 Identities = 64/193 (33%), Positives = 107/193 (55%), Gaps = 1/193 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K++ K+++ +RRE++I L H N+++ Y+ DA VY+++E GE Sbjct: 69 VALKVLFKSQIEKEGLEHQLRREIEIQAHLQ-HPNILRLYNYFHDARRVYLILEYAPRGE 127 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L L + + E+ I+ ++ + +CH + V+HRD+KPEN L R E +K+ Sbjct: 128 LYKE-LQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGE---VKIA 183 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFG S P R + G+ Y+ PE++ R+Y + D+W IGV+ Y LL G PF + Sbjct: 184 DFGWSVHT-PSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESA 242 Query: 564 TESGIFRSVLRAD 602 + S +R +L+ D Sbjct: 243 SHSETYRRILKVD 255
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 108 bits (270), Expect = 1e-23 Identities = 61/182 (33%), Positives = 99/182 (54%), Gaps = 7/182 (3%) Frame = +3 Query: 30 AVKIISKAKMTTAISI----EDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 AVK ++K T+ ++ + E+++ K +GH N++ FY+ E+ ++V+E + Sbjct: 36 AVKFVNKKHATSCMNAGVWARRMASEIQLHKLCNGHKNIIHFYNTAENPQWRWVVLEFAQ 95 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GG+L D+I G E+ A+ Q++ ++F H +GV HRDLKPEN L D N + Sbjct: 96 GGDLFDKIEPDVG-IDEDVAQFYFAQLMEGISFMHSKGVAHRDLKPENILL---DYNGNL 151 Query: 378 KLIDFGLSDFIR---PDERLNDIVGSAYYVAPEVLHRSYSMEADIWSIGVITYILLCGSR 548 K+ DFG + LN VGS Y APE+ + + D+WS G+I + LL G+ Sbjct: 152 KISDFGFASLFSYKGKSRLLNSPVGSPPYAAPEITQQYDGSKVDVWSCGIILFALLLGNT 211 Query: 549 PF 554 P+ Sbjct: 212 PW 213
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 108 bits (270), Expect = 1e-23 Identities = 74/212 (34%), Positives = 109/212 (51%), Gaps = 2/212 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G+ VA+K+I K + T + +R EV IL+ L H +V E V++VME Sbjct: 599 GRDVAIKVIDKMRFPTKQESQ-LRNEVAILQNLH-HPGIVNLECMFETPERVFVVMEKLH 656 Query: 198 GGELLDRILA-RGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP 374 G ++L+ IL+ R E K +V QIL + H + +VH DLKPEN L + + Sbjct: 657 G-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQ 715 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRP 551 +KL DFG + I +VG+ Y+APEVL + Y+ D+WS+GVI Y+ L G+ P Sbjct: 716 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFP 775 Query: 552 FWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 F + I + A +PW +S EA Sbjct: 776 F--NEDEDINDQIQNAAFMYPPNPWREISGEA 805
>TSSK3_HUMAN (Q96PN8) Testis-specific serine/threonine-protein kinase 3 (EC| 2.7.11.1) (TSSK-3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C) Length = 268 Score = 108 bits (269), Expect = 2e-23 Identities = 68/181 (37%), Positives = 99/181 (54%), Gaps = 5/181 (2%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALN-VYIVMELCEGG 203 VA+K+I K + RE++I++ L H N+++ Y+ E A + +VMEL EGG Sbjct: 36 VAIKVIDKMGGPEEFIQRFLPRELQIVRTLD-HKNIIQVYEMLESADGKICLVMELAEGG 94 Query: 204 ELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKL 383 ++ D +L GG E AKA+ Q++ + +CH GV HRDLK EN L + +KL Sbjct: 95 DVFDCVL-NGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALL----QGFNLKL 149 Query: 384 IDFGLSDFIRPDER--LNDIVGSAYYVAPEVLH--RSYSMEADIWSIGVITYILLCGSRP 551 DFG + + R GS Y APEVL S + D+WS+GV+ Y++LC S P Sbjct: 150 TDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLP 209 Query: 552 F 554 F Sbjct: 210 F 210
>SAPKA_ORYSA (Q75H77) Serine/threonine-protein kinase SAPK10 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 10) Length = 362 Score = 108 bits (269), Expect = 2e-23 Identities = 73/196 (37%), Positives = 108/196 (55%), Gaps = 3/196 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 GQ VAVK I + E+V+RE+ ++L H N+++F + ++ IVME Sbjct: 46 GQLVAVKYIERGDKID----ENVQREIINHRSLR-HPNIIRFKEVILTPTHLAIVMEYAS 100 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP- 374 GGEL +RI GR++E++A+ Q++S V++CH V HRDLK EN L AP Sbjct: 101 GGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLD--GSTAPR 157 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSME-ADIWSIGVITYILLCGSR 548 +K+ DFG S + VG+ Y+APEV L + Y + AD+WS GV Y++L G+ Sbjct: 158 LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKIADVWSCGVTLYVMLVGAY 217 Query: 549 PFWARTESGIFRSVLR 596 PF E FR ++ Sbjct: 218 PFEDPDEPKNFRKTIQ 233
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 108 bits (269), Expect = 2e-23 Identities = 72/205 (35%), Positives = 107/205 (52%), Gaps = 10/205 (4%) Frame = +3 Query: 9 EYKGQTVAVKIISKAKMTT--------AISIEDVRREVKILKALSGHNNLVKFYDACEDA 164 E G AVK+ISK+ ++ ++ RE+ I+K LS H N++ YD E Sbjct: 41 ERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLS-HPNVLSLYDVWETN 99 Query: 165 LNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENF 344 N+Y+++E E GEL + +L G E +A QI+ +++CH G+VHRDLKPEN Sbjct: 100 NNLYLILEYAEKGELFN-LLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENL 158 Query: 345 LFTTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH--RSYSMEADIWSIGV 518 L D +K+ DFG++ + L GS +Y APE++ +D+WS GV Sbjct: 159 LL---DSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGV 215 Query: 519 ITYILLCGSRPFWARTESGIFRSVL 593 I + LL G PF E+G R +L Sbjct: 216 ILFALLTGRLPF--DEENGNVRDLL 238
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 107 bits (268), Expect = 2e-23 Identities = 61/193 (31%), Positives = 105/193 (54%), Gaps = 1/193 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 +A+K++ K+++ A +RREV+I L H N+++ Y DA VY++++ GGE Sbjct: 166 LALKVLFKSQLEKAGVEHQLRREVEIQSHLR-HPNILRLYGYFHDASRVYLILDYAPGGE 224 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L R L + R+ ++ + + Q+ + +CH + V+HRD+KPEN L N +K+ Sbjct: 225 LF-RELQKCTRFDDQRSALYIKQLAEALLYCHSKKVIHRDIKPENLLL---GSNGELKIA 280 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFG S P R + G+ Y+ PE++ R + + D+WS+GV+ Y L G PF Sbjct: 281 DFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFETD 339 Query: 564 TESGIFRSVLRAD 602 T +R + + + Sbjct: 340 THQETYRRISKVE 352
>MKNK2_HUMAN (Q9HBH9) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 465 Score = 107 bits (268), Expect = 2e-23 Identities = 78/238 (32%), Positives = 110/238 (46%), Gaps = 29/238 (12%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q AVKII K V REV++L GH N+++ + E+ Y+V E G Sbjct: 108 QEYAVKIIEKQPGHIR---SRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRG 164 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G +L I R + E +A +V + S + F H +G+ HRDLKPEN L ++ +P+K Sbjct: 165 GSILSHIHKRR-HFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK 223 Query: 381 LIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLH------RSYSMEADIWSIGV 518 + DF L I+ + + I GSA Y+APEV+ Y D+WS+GV Sbjct: 224 ICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGV 283 Query: 519 ITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 I YILL G PF W R E + +F S+ D W +S A Sbjct: 284 ILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAA 341
>MAPK5_MOUSE (O54992) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) Length = 473 Score = 107 bits (268), Expect = 2e-23 Identities = 72/243 (29%), Positives = 116/243 (47%), Gaps = 36/243 (14%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIE--DVRREVKILKALSGHNNLVKFYDACEDALN---------- 170 V VK ++ + I ++ R EV++ + H N+V+ + +++ Sbjct: 38 VCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRAR 97 Query: 171 VYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLF 350 + IVME+ EGGEL RI ++ +TE+ A + QI + CHL + HRDLKPEN LF Sbjct: 98 LLIVMEMMEGGELFHRI-SQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLF 156 Query: 351 TTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR----------------- 479 +AP+KL DFG + + D L + YYVAP+VL Sbjct: 157 KDNSLDAPVKLCDFGFAKVDQGD--LMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPT 214 Query: 480 --SYSMEADIWSIGVITYILLCGSRPFWARTES-----GIFRSVLRADPNLDDSPWPSVS 638 +Y+ D+WS+GVI Y++LCG PF+++ S + + ++ + W +S Sbjct: 215 PYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQIS 274 Query: 639 AEA 647 A Sbjct: 275 EMA 277
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 107 bits (268), Expect = 2e-23 Identities = 66/196 (33%), Positives = 104/196 (53%), Gaps = 1/196 (0%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G A+K + K ++ + RREV+I + H NL + Y D VY++ME Sbjct: 123 GLICALKAMEKKEIVQYTIQKQFRREVEIQGSFK-HKNLTQLYGFFYDEKRVYLLMEYVY 181 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPM 377 GEL + L G E A V Q+ + + + H + ++HRD+KPEN L N + Sbjct: 182 YGELY-KFLKNNGPLNETLASYFVYQMANALDYMHSKNILHRDIKPENILIGF---NNTI 237 Query: 378 KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPF 554 KL DFG S + ++ + G+ Y++PE++ R Y+ + D+W++GV+TY LL GS PF Sbjct: 238 KLTDFGWSVYNEDGQKRKTLCGTIDYLSPELIKSREYNNKVDVWALGVLTYELLVGSPPF 297 Query: 555 WARTESGIFRSVLRAD 602 T+ +R +LR D Sbjct: 298 EEDTKEMTYRRILRCD 313
>SAPK3_ORYSA (Q75V63) Serine/threonine-protein kinase SAPK3 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 3) (Protein kinase REK) Length = 334 Score = 107 bits (268), Expect = 2e-23 Identities = 67/180 (37%), Positives = 100/180 (55%), Gaps = 2/180 (1%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 + VAVK I + K E+V+RE+ ++L H N+++F + C ++ IVME G Sbjct: 29 ELVAVKYIERGKKID----ENVQREIINHRSLR-HPNIIRFKEVCLTPTHLAIVMEYAAG 83 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 GEL ++I GR++E++A+ Q++S V++CH + HRDLK EN L +K Sbjct: 84 GELFEQICT-AGRFSEDEARYFFQQLISGVSYCHSLEICHRDLKLENTLL-DGSPTPRVK 141 Query: 381 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--SMEADIWSIGVITYILLCGSRPF 554 + DFG S + VG+ Y+APEVL R AD+WS GV Y++L GS PF Sbjct: 142 ICDFGYSKSALLHSKPKSTVGTPAYIAPEVLSRKEYDGKVADVWSCGVTLYVMLVGSYPF 201
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 107 bits (266), Expect = 4e-23 Identities = 70/198 (35%), Positives = 109/198 (55%), Gaps = 9/198 (4%) Frame = +3 Query: 69 ISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTE 248 +S +D+ +EV + S H N+++ D ++I++E+ +GG+L D+I G Sbjct: 57 LSDKDITKEVVLQSKCSKHPNVLRLIDCNVSKEYMWIILEMADGGDLFDKIEPDVG-VDS 115 Query: 249 EDAKAIVVQILSVVAFCHLQ-GVVHRDLKPENFLFTTRDENAPMKLIDFGL-SDFIRPDE 422 + A+ Q++S + + H++ GV HRD+KPEN L D+N +KL DFGL S F R D Sbjct: 116 DVAQFYFQQLVSAINYLHVECGVAHRDIKPENILL---DKNGNLKLADFGLASQFRRKDG 172 Query: 423 RLN---DIVGSAYYVAPEVLHRS---YSMEADIWSIGVITYILLCGSRPF-WARTESGIF 581 L D GS Y+APEVL+ Y+ DIWSIG++ ++LL G P+ E+ F Sbjct: 173 TLRVSMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLLTGQTPWELPSLENEDF 232 Query: 582 RSVLRADPNLDDSPWPSV 635 + D NL+ PW + Sbjct: 233 VFFIENDGNLNWGPWSKI 250
>POLO_DROME (P52304) Serine/threonine-protein kinase polo (EC 2.7.11.21)| Length = 576 Score = 107 bits (266), Expect = 4e-23 Identities = 66/193 (34%), Positives = 108/193 (55%), Gaps = 2/193 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A KI+SK M E +E+ I ++L+ H N+VKF++ ED+ N+YIV+ELC+ + Sbjct: 52 AGKIVSKKLMIKHNQKEKTAQEITIHRSLN-HPNIVKFHNYFEDSQNIYIVLELCKKRSM 110 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 ++ + R TE + + + QI+ V + H ++HRDLK N ++ +K+ D Sbjct: 111 ME-LHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFL---NDLLHVKIGD 166 Query: 390 FGLSDFIRPD-ERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 FGL+ I + ER + G+ Y+APE+L + +S E DIWSIG + Y LL G PF + Sbjct: 167 FGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETK 226 Query: 564 TESGIFRSVLRAD 602 T + + + + Sbjct: 227 TLKDTYSKIKKCE 239
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 107 bits (266), Expect = 4e-23 Identities = 61/193 (31%), Positives = 104/193 (53%), Gaps = 1/193 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 +A+K++ K+++ A +RREV+I L H N+++ Y DA VY++++ GGE Sbjct: 166 LALKVLFKSQLEKAGVEHQLRREVEIQSHLR-HPNILRLYGYFHDASRVYLILDYAPGGE 224 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L R L + R+ ++ + + Q+ + +CH + V+HRD+KPEN L N +K+ Sbjct: 225 LF-RELQKCTRFDDQRSAMYIKQLAEALLYCHSKKVIHRDIKPENLLL---GSNGELKIA 280 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFG S P R + G+ Y+ PE++ R + D+WS+GV+ Y L G PF Sbjct: 281 DFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMHDETVDLWSLGVLCYEFLVGKPPFETD 339 Query: 564 TESGIFRSVLRAD 602 T +R + + + Sbjct: 340 THQETYRRISKVE 352
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 107 bits (266), Expect = 4e-23 Identities = 67/198 (33%), Positives = 104/198 (52%), Gaps = 19/198 (9%) Frame = +3 Query: 18 GQTVAVKIISK-----AKMTTAISIEDVR-------REVKI-----LKALSGHNNLVKFY 146 G+ A+KI+++ K A S E + +E++ L L H + + Sbjct: 148 GEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEKNKEIRTVREAALSTLLRHPYICEAR 207 Query: 147 DACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRD 326 D + Y+V E +GG++LD I++ G + E+ A+ V QI S +++ H VVHRD Sbjct: 208 DVYITNSHYYMVFEFVDGGQMLDYIISHG-KLKEKQARKFVRQIGSALSYLHQNSVVHRD 266 Query: 327 LKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS--YSMEAD 500 LK EN L + + +K+IDFGLS+ R RL GS Y+ APE+L+ E D Sbjct: 267 LKIENILIS---KTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVD 323 Query: 501 IWSIGVITYILLCGSRPF 554 +WS G++ Y+L+CG PF Sbjct: 324 VWSFGIVLYVLVCGKVPF 341
>MKNK2_RAT (Q5U2N4) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 106 bits (265), Expect = 5e-23 Identities = 78/238 (32%), Positives = 110/238 (46%), Gaps = 29/238 (12%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q AVKII K V REV++L GH N+++ + E+ Y+V E G Sbjct: 108 QEYAVKIIEKQLGHIR---SRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRG 164 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G +L I R + E +A +V + S + F H +G+ HRDLKPEN L ++ +P+K Sbjct: 165 GSILSHIHRRR-HFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK 223 Query: 381 LIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLH------RSYSMEADIWSIGV 518 + DF L I+ + + I GSA Y+APEV+ Y D+WS+GV Sbjct: 224 ICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGV 283 Query: 519 ITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 I YILL G PF W R E + +F S+ D W +S A Sbjct: 284 ILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAA 341
>MKNK2_MOUSE (Q8CDB0) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 106 bits (265), Expect = 5e-23 Identities = 78/238 (32%), Positives = 110/238 (46%), Gaps = 29/238 (12%) Frame = +3 Query: 21 QTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEG 200 Q AVKII K V REV++L GH N+++ + E+ Y+V E G Sbjct: 108 QEYAVKIIEKQLGHIR---SRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRG 164 Query: 201 GELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMK 380 G +L I R + E +A +V + S + F H +G+ HRDLKPEN L ++ +P+K Sbjct: 165 GSILSHIHRRR-HFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK 223 Query: 381 LIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLH------RSYSMEADIWSIGV 518 + DF L I+ + + I GSA Y+APEV+ Y D+WS+GV Sbjct: 224 ICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGV 283 Query: 519 ITYILLCGSRPF---------WARTE------SGIFRSVLRADPNLDDSPWPSVSAEA 647 I YILL G PF W R E + +F S+ D W +S A Sbjct: 284 ILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAA 341
>MAPK2_RABIT (P49139) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) (Fragments) Length = 330 Score = 106 bits (265), Expect = 5e-23 Identities = 64/164 (39%), Positives = 90/164 (54%), Gaps = 6/164 (3%) Frame = +3 Query: 87 RREVKILKALSGHNNLVKFYDACEDALN----VYIVMELCEGGELLDRILARGGR-YTEE 251 RREV++ S ++V+ D E+ + IVME +GG L RI RG + +TE Sbjct: 68 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGLLFSRIQDRGDQAFTER 127 Query: 252 DAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLN 431 +A I+ I + + H + HRD+KPEN L+T++ A +KL DFG + L Sbjct: 128 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPKAILKLTDFGFAKETTSHNSLT 187 Query: 432 DIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWA 560 + YYVAPEVL Y D+WS+GVI YILLCG PF++ Sbjct: 188 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYS 231
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 106 bits (265), Expect = 5e-23 Identities = 64/204 (31%), Positives = 110/204 (53%), Gaps = 4/204 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+KI+ K + + V RE ++ L H VK Y +D +Y + + GEL Sbjct: 112 AIKILEKRHIIKENKVPYVTRERDVMSRLD-HPFFVKLYFTFQDDEKLYFGLSYAKNGEL 170 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 L + + + G + E + +I+S + + H +G++HRDLKPEN L +E+ +++ D Sbjct: 171 L-KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILL---NEDMHIQITD 226 Query: 390 FGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFW 557 FG + + PD R N VG+A YV+PE+L +S +D+W++G I Y L+ G PF Sbjct: 227 FGTAKVLSPDSKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFR 286 Query: 558 ARTESGIFRSVLRADPNLDDSPWP 629 A E IF+ +++ + + + +P Sbjct: 287 AGNEYLIFQKIIKLEYDFPEKFFP 310
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 105 bits (263), Expect = 9e-23 Identities = 58/196 (29%), Positives = 106/196 (54%), Gaps = 1/196 (0%) Frame = +3 Query: 12 YKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMEL 191 + G+ A+K++ K ++ +E E ++LK + H L++ + +DA N+++VM+ Sbjct: 91 HNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVE-HPFLIRMWGTFQDARNIFMVMDY 149 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 EGGEL +L + R+ AK +++ + + H +++RDLKPEN L D N Sbjct: 150 IEGGELFS-LLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILL---DRNG 205 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSR 548 +K+ DFG + ++ + G+ Y+APEV+ + Y+ D WS+GV+ Y +L G Sbjct: 206 HIKITDFGFAKEVQTVTW--TLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYT 263 Query: 549 PFWARTESGIFRSVLR 596 PF+ T + +L+ Sbjct: 264 PFYDTTPMKTYEKILQ 279
>SAPK9_ORYSA (Q75V57) Serine/threonine-protein kinase SAPK9 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 9) Length = 361 Score = 105 bits (263), Expect = 9e-23 Identities = 71/196 (36%), Positives = 109/196 (55%), Gaps = 3/196 (1%) Frame = +3 Query: 18 GQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCE 197 G VAVK I + + E+V+RE+ ++L H N+++F + ++ IVME Sbjct: 45 GDLVAVKYIDRGEKID----ENVQREIINHRSLR-HPNIIRFKEVILTPTHLAIVMEYAS 99 Query: 198 GGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAP- 374 GGEL +RI + GR++E++A+ Q++S V++CH V HRDLK EN L AP Sbjct: 100 GGELFERICS-AGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLD--GSTAPR 156 Query: 375 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSME-ADIWSIGVITYILLCGSR 548 +K+ DFG S + VG+ Y+APEV L + Y + AD+WS GV Y++L G+ Sbjct: 157 LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKIADVWSCGVTLYVMLVGAY 216 Query: 549 PFWARTESGIFRSVLR 596 PF + FR ++ Sbjct: 217 PFEDPEDPKNFRKTIQ 232
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 105 bits (262), Expect = 1e-22 Identities = 57/159 (35%), Positives = 95/159 (59%), Gaps = 2/159 (1%) Frame = +3 Query: 84 VRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGELLDRILARGGRYTEEDAKA 263 + RE+ I+K +S H N++ ++ E+ +Y+V+E +GGEL D ++++G + E +A Sbjct: 161 IEREIVIMKLIS-HTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKG-KLPEREAIH 218 Query: 264 IVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLIDFGLSDFIRPDERLNDIVG 443 QI+ V++CH + HRDLKPEN L + N +K+ DFG++ P++ L G Sbjct: 219 YFKQIVEGVSYCHSFNICHRDLKPENLLLDKK--NRRIKIADFGMAALELPNKLLKTSCG 276 Query: 444 SAYYVAPE-VLHRSY-SMEADIWSIGVITYILLCGSRPF 554 S +Y +PE V+ R Y +D+WS G++ + LL G PF Sbjct: 277 SPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPF 315
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 105 bits (262), Expect = 1e-22 Identities = 62/185 (33%), Positives = 104/185 (56%), Gaps = 1/185 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K + G VA+K + K+++ + + VRRE++I L H N+++ Y D +Y++ Sbjct: 107 KEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLR-HKNILRLYGHFHDEKRIYLI 165 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +E GEL L R R++EE A + Q+ + +++ H + V+HRD+KPEN L Sbjct: 166 LEFAGRGELYQH-LRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKPENILLGIDG 224 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLC 539 E +KL DFG S P R + G+ Y+ PE++ + ++ + D+WS+GV+TY L Sbjct: 225 E---IKLSDFGWS-VHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLV 280 Query: 540 GSRPF 554 G+ PF Sbjct: 281 GAPPF 285
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 105 bits (261), Expect = 2e-22 Identities = 63/204 (30%), Positives = 110/204 (53%), Gaps = 4/204 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+KI+ K + + V RE ++ L H VK Y +D +Y + + GEL Sbjct: 109 AIKILEKRHIIKENKVPYVTRERDVMSRLD-HPFFVKLYFTFQDDEKLYFGLSYAKNGEL 167 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 L + + + G + E + +I+S + + H +G++HRDLKPEN L +E+ +++ D Sbjct: 168 L-KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILL---NEDMHIQITD 223 Query: 390 FGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFW 557 FG + + P+ R N VG+A YV+PE+L +S +D+W++G I Y L+ G PF Sbjct: 224 FGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFR 283 Query: 558 ARTESGIFRSVLRADPNLDDSPWP 629 A E IF+ +++ + + + +P Sbjct: 284 AGNEYLIFQKIIKLEYDFPEKFFP 307
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 105 bits (261), Expect = 2e-22 Identities = 69/216 (31%), Positives = 111/216 (51%), Gaps = 1/216 (0%) Frame = +3 Query: 3 KGEYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIV 182 K + G A+K + K ++ + RREV+I L H N+++ + D VY++ Sbjct: 117 KDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLR-HTNVLRLFGHFHDKDRVYLI 175 Query: 183 MELCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRD 362 +E GEL ++L R+TE A + + Q+ + + H + ++HRD+KPEN L D Sbjct: 176 LEYVVHGELY-KLLRNQKRFTESTASSYIYQMSEALLYLHGKNIIHRDIKPENILLHFND 234 Query: 363 ENAPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLC 539 +K+ DFG S P R + + G+ Y+ PE++ R Y D+WS+G++ Y LC Sbjct: 235 ---TIKISDFGWS-VHAPSNRRSTLCGTMDYLPPEIVQSRPYDKNVDVWSLGILMYEFLC 290 Query: 540 GSRPFWARTESGIFRSVLRADPNLDDSPWPSVSAEA 647 G+ PF E G ++ R LD P VSA+A Sbjct: 291 GAPPF---EEPGGAQATYRRIVKLDLRIPPYVSADA 323
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 105 bits (261), Expect = 2e-22 Identities = 70/204 (34%), Positives = 102/204 (50%), Gaps = 16/204 (7%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+K++ K + + V E + L LS H +K + +DA N+Y V+ L GEL Sbjct: 126 AIKVLDKRHIIKEKKEKYVNIEKEALCILSKHPGFIKLFYTFQDAHNLYFVLSLARNGEL 185 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 LD I + GR+ E A+ I+ + + H +GV+HRDLKPEN L D+N K+ D Sbjct: 186 LDYI-NKLGRFNEICAQYYAALIVDSIDYMHGRGVIHRDLKPENILL---DDNMRTKITD 241 Query: 390 FGLSDFI---------------RPDERLNDIVGSAYYVAPEVLHRSYSMEA-DIWSIGVI 521 FG + + +P VG+A YV+PEVL + A DIW+ G I Sbjct: 242 FGSAKILNSSHGSHEEDTHHADKPQAHSRSFVGTARYVSPEVLSDKIAGTASDIWAFGCI 301 Query: 522 TYILLCGSRPFWARTESGIFRSVL 593 + +L G PF A E F+S+L Sbjct: 302 LFQMLAGKPPFVAGNEYLTFQSIL 325
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 105 bits (261), Expect = 2e-22 Identities = 61/198 (30%), Positives = 107/198 (54%), Gaps = 1/198 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 +A+K++ KA++ A +RREV+I L H N+++ Y DA VY+++E G Sbjct: 159 LALKVLFKAQLEKAGVEHQLRREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGT 217 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + R L + ++ E+ + ++ + +++CH + V+HRD+KPEN L + E +K+ Sbjct: 218 VY-RELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE---LKIA 273 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFG S P R + G+ Y+ PE++ R + + D+WS+GV+ Y L G PF A Sbjct: 274 DFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332 Query: 564 TESGIFRSVLRADPNLDD 617 T ++ + R + D Sbjct: 333 TYQETYKRISRVEFTFPD 350
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 105 bits (261), Expect = 2e-22 Identities = 61/198 (30%), Positives = 105/198 (53%), Gaps = 1/198 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 +A+K++ K ++ A +RREV+I L H N+++ Y DA VY+++E G Sbjct: 150 LALKVLFKTQLEKANVEHQLRREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGT 208 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 + R L + ++ E+ + ++ + +++CH + V+HRD+KPEN L N +K+ Sbjct: 209 VY-RELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL---GSNGELKIA 264 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFG S P R + G+ Y+ PE++ R + + D+WS+GV+ Y L G PF A Sbjct: 265 DFGWS-VHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAH 323 Query: 564 TESGIFRSVLRADPNLDD 617 T +R + R + D Sbjct: 324 TYQETYRRISRVEFTFPD 341
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 105 bits (261), Expect = 2e-22 Identities = 63/204 (30%), Positives = 110/204 (53%), Gaps = 4/204 (1%) Frame = +3 Query: 30 AVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGEL 209 A+KI+ K + + V RE ++ L H VK Y +D +Y + + GEL Sbjct: 112 AIKILEKRHIIKENKVPYVTRERDVMSRLD-HPFFVKLYFTFQDDEKLYFGLSYAKNGEL 170 Query: 210 LDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLID 389 L + + + G + E + +I+S + + H +G++HRDLKPEN L +E+ +++ D Sbjct: 171 L-KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILL---NEDMHIQITD 226 Query: 390 FGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFW 557 FG + + P+ R N VG+A YV+PE+L +S +D+W++G I Y L+ G PF Sbjct: 227 FGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFR 286 Query: 558 ARTESGIFRSVLRADPNLDDSPWP 629 A E IF+ +++ + + + +P Sbjct: 287 AGNEYLIFQKIIKLEYHFPEKFFP 310
>TSSK2_HUMAN (Q96PF2) Testis-specific serine/threonine-protein kinase 2 (EC| 2.7.11.1) (TSSK-2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G) Length = 358 Score = 104 bits (260), Expect = 2e-22 Identities = 74/184 (40%), Positives = 105/184 (57%), Gaps = 8/184 (4%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALN-VYIVMELCEGG 203 VAVKII + K T + RE+ IL ++ H +++K Y+ E + +YI+MEL G Sbjct: 38 VAVKIIDRKKTPTDFVERFLPREMDILATVN-HGSIIKTYEIFETSDGRIYIIMELGVQG 96 Query: 204 ELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKL 383 +LL+ I +G + E+ A+ + Q+ S V +CH +VHRDLK EN L D++ +KL Sbjct: 97 DLLEFIKCQGALH-EDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLL---DKDFNIKL 152 Query: 384 IDFGLSDFIRPDERLNDIV-----GSAYYVAPEVLHR-SYSMEA-DIWSIGVITYILLCG 542 DFG S D I+ GSA Y APEVL Y + DIWS+GVI YI++CG Sbjct: 153 SDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCG 212 Query: 543 SRPF 554 S P+ Sbjct: 213 SMPY 216
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 104 bits (260), Expect = 2e-22 Identities = 62/193 (32%), Positives = 104/193 (53%), Gaps = 1/193 (0%) Frame = +3 Query: 27 VAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVMELCEGGE 206 VA+K++ K+++ +RREV+I L H N+++ Y+ D +Y+++E GGE Sbjct: 42 VALKVLFKSEIEKEGLEHQLRREVEIQAHLQ-HRNILRLYNYFYDDTRIYLILEYAPGGE 100 Query: 207 LLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENAPMKLI 386 L L R + ++ I+ ++ + +CH + V+HRD+KPEN L N +K+ Sbjct: 101 LYKE-LQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGL---NGEVKIS 156 Query: 387 DFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCGSRPFWAR 563 DFG S P R + G+ Y+ PE++ + Y+ D+W IGV+ Y LL G PF + Sbjct: 157 DFGWSVHT-PSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFESS 215 Query: 564 TESGIFRSVLRAD 602 T S +R + + D Sbjct: 216 TSSETYRRIRQVD 228
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 104 bits (260), Expect = 2e-22 Identities = 69/210 (32%), Positives = 114/210 (54%), Gaps = 2/210 (0%) Frame = +3 Query: 9 EYKGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNNLVKFYDACEDALNVYIVME 188 +Y Q VA+K I K + + +++RE++I++ L H N+V D+ E V +V + Sbjct: 24 KYSAQVVALKFIPKLGRSEK-ELRNLQREIEIMRGLR-HPNIVHMLDSFETDKEVVVVTD 81 Query: 189 LCEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDEN 368 EG ELL +IL G+ E+ +AI Q++S + + H ++HRD+KP+N L + Sbjct: 82 YAEG-ELL-QILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA---KG 136 Query: 369 APMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVL-HRSYSMEADIWSIGVITYILLCG 542 +KL DFG + + + L I G+ Y++PE++ R Y AD+WS+G I Y L G Sbjct: 137 GGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVG 196 Query: 543 SRPFWARTESGIFRSVLRADPNLDDSPWPS 632 + PF+A + + +L+ D WPS Sbjct: 197 TPPFYATSIFQLVSLILK-----DPVRWPS 221
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 104 bits (259), Expect = 3e-22 Identities = 62/196 (31%), Positives = 106/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 15 KGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNN-LVKFYDACEDALNVYIVMEL 191 + +T A+KI+ K + E +R E +I++ H++ +V+ Y +D+ +Y++ME Sbjct: 382 ESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG--AHSDFIVRLYRTFKDSKYLYMLMEA 439 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GGEL IL G + + + ++ A+ H +G+++RDLKPEN + D Sbjct: 440 CLGGELWT-ILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLIL---DHRG 495 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSR 548 KL+DFG + I ++ G+ YVAPE+ L++ + + AD WS+G++ Y LL GS Sbjct: 496 YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 555 Query: 549 PFWARTESGIFRSVLR 596 PF + +LR Sbjct: 556 PFSGPDPMKTYNIILR 571
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 104 bits (259), Expect = 3e-22 Identities = 62/196 (31%), Positives = 106/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 15 KGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNN-LVKFYDACEDALNVYIVMEL 191 + +T A+KI+ K + E +R E +I++ H++ +V+ Y +D+ +Y++ME Sbjct: 382 ESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG--AHSDFIVRLYRTFKDSKYLYMLMEA 439 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GGEL IL G + + + ++ A+ H +G+++RDLKPEN + D Sbjct: 440 CLGGELWT-ILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLIL---DHRG 495 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSR 548 KL+DFG + I ++ G+ YVAPE+ L++ + + AD WS+G++ Y LL GS Sbjct: 496 YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 555 Query: 549 PFWARTESGIFRSVLR 596 PF + +LR Sbjct: 556 PFSGPDPMKTYNIILR 571
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 104 bits (259), Expect = 3e-22 Identities = 62/196 (31%), Positives = 106/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 15 KGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNN-LVKFYDACEDALNVYIVMEL 191 + +T A+KI+ K + E +R E +I++ H++ +V+ Y +D+ +Y++ME Sbjct: 382 ESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG--AHSDFIVRLYRTFKDSKYLYMLMEA 439 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GGEL IL G + + + ++ A+ H +G+++RDLKPEN + D Sbjct: 440 CLGGELWT-ILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLIL---DHRG 495 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSR 548 KL+DFG + I ++ G+ YVAPE+ L++ + + AD WS+G++ Y LL GS Sbjct: 496 YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 555 Query: 549 PFWARTESGIFRSVLR 596 PF + +LR Sbjct: 556 PFSGPDPMKTYNIILR 571
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 104 bits (259), Expect = 3e-22 Identities = 62/196 (31%), Positives = 106/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 15 KGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNN-LVKFYDACEDALNVYIVMEL 191 + +T A+KI+ K + E +R E +I++ H++ +V+ Y +D+ +Y++ME Sbjct: 398 ESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG--AHSDFIVRLYRTFKDSKYLYMLMEA 455 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GGEL IL G + + + ++ A+ H +G+++RDLKPEN + D Sbjct: 456 CLGGELWT-ILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLIL---DHRG 511 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSR 548 KL+DFG + I ++ G+ YVAPE+ L++ + + AD WS+G++ Y LL GS Sbjct: 512 YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 571 Query: 549 PFWARTESGIFRSVLR 596 PF + +LR Sbjct: 572 PFSGPDPMKTYNIILR 587
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 104 bits (259), Expect = 3e-22 Identities = 62/196 (31%), Positives = 106/196 (54%), Gaps = 2/196 (1%) Frame = +3 Query: 15 KGQTVAVKIISKAKMTTAISIEDVRREVKILKALSGHNN-LVKFYDACEDALNVYIVMEL 191 + +T A+KI+ K + E +R E +I++ H++ +V+ Y +D+ +Y++ME Sbjct: 398 ESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG--AHSDFIVRLYRTFKDSKYLYMLMEA 455 Query: 192 CEGGELLDRILARGGRYTEEDAKAIVVQILSVVAFCHLQGVVHRDLKPENFLFTTRDENA 371 C GGEL IL G + + + ++ A+ H +G+++RDLKPEN + D Sbjct: 456 CLGGELWT-ILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLIL---DHRG 511 Query: 372 PMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSMEADIWSIGVITYILLCGSR 548 KL+DFG + I ++ G+ YVAPE+ L++ + + AD WS+G++ Y LL GS Sbjct: 512 YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 571 Query: 549 PFWARTESGIFRSVLR 596 PF + +LR Sbjct: 572 PFSGPDPMKTYNIILR 587 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 88,305,815 Number of Sequences: 219361 Number of extensions: 1768387 Number of successful extensions: 9425 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6410 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6708 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6086476506 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
