ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags36a10 |
|---|---|
| Clone Library Name | barley_pub |
>UPL2_ARATH (Q8H0T4) E3 ubiquitin protein ligase UPL2 (EC 6.3.2.-)| (Ubiquitin-protein ligase 2) Length = 3658 Score = 393 bits (1009), Expect = e-109 Identities = 190/219 (86%), Positives = 205/219 (93%), Gaps = 1/219 (0%) Frame = +3 Query: 3 RLLNAFIRQNSGLLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDHHHS-PVRISVRRA 179 RLLN+F+RQN LLEKSFS+MLK PRLIDFDNK+AYFRS+I+HQHD H S P+RISVRRA Sbjct: 3244 RLLNSFVRQNPSLLEKSFSMMLKAPRLIDFDNKKAYFRSRIRHQHDQHISGPLRISVRRA 3303 Query: 180 YILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV 359 Y+LEDSYNQLRMRSPQDLKGRL V FQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV Sbjct: 3304 YVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV 3363 Query: 360 GNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHD 539 GND TFQPNPNSVYQTEHLSYFKFVGR+V KALFD QLLDV+FTRSFYKHILG KVTYHD Sbjct: 3364 GNDATFQPNPNSVYQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHD 3423 Query: 540 IEAIDPAYYRNLKWMLENDISDVLDLTFSMDADEEKLIL 656 IEA+DP YY+NLKW+LEND+SD+LDLTFSMDADEEK IL Sbjct: 3424 IEAVDPDYYKNLKWLLENDVSDILDLTFSMDADEEKHIL 3462
>UPL1_ARATH (Q8GY23) E3 ubiquitin protein ligase UPL1 (EC 6.3.2.-)| (Ubiquitin-protein ligase 1) Length = 3684 Score = 391 bits (1004), Expect = e-108 Identities = 190/219 (86%), Positives = 204/219 (93%), Gaps = 1/219 (0%) Frame = +3 Query: 3 RLLNAFIRQNSGLLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDHHHS-PVRISVRRA 179 RLLN+FIRQN LLEKS S+MLK PRLIDFDNK+AYFRS+I+HQHD H S P+RISVRRA Sbjct: 3267 RLLNSFIRQNPSLLEKSLSMMLKAPRLIDFDNKKAYFRSRIRHQHDQHISGPLRISVRRA 3326 Query: 180 YILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV 359 Y+LEDSYNQLRMRSPQDLKGRL V FQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV Sbjct: 3327 YVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV 3386 Query: 360 GNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHD 539 GND TFQPNPNSVYQTEHLSYFKFVGR+V KALFD QLLDV+FTRSFYKHILG KVTYHD Sbjct: 3387 GNDATFQPNPNSVYQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHD 3446 Query: 540 IEAIDPAYYRNLKWMLENDISDVLDLTFSMDADEEKLIL 656 IEA+DP YY+NLKW+LEND+SD+LDLTFSMDADEEK IL Sbjct: 3447 IEAVDPDYYKNLKWLLENDVSDILDLTFSMDADEEKHIL 3485
>TOM1_NEUCR (Q9P4Z1) E3 ubiquitin protein ligase TOM1-like protein (EC 6.3.2.-)| Length = 4065 Score = 214 bits (544), Expect = 2e-55 Identities = 100/217 (46%), Positives = 151/217 (69%), Gaps = 5/217 (2%) Frame = +3 Query: 3 RLLNAFIRQNSGLLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHD---HHHSPVRISVR 173 R+LN +R N L+ +FSL++K P++++FDNKR YF + ++ H P+++ VR Sbjct: 3654 RILNELVRHNPKLMSGTFSLLVKNPKVLEFDNKRNYFNRSVHSKYQQTRHSFPPLQLQVR 3713 Query: 174 RAYILEDSYNQLRMRSPQDLK-GRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF 350 R ++ DS+ L + +LK G+L + FQGEEG+DAGG+TREW+Q+LSR +FD +LF Sbjct: 3714 REHVFHDSFRSLYYKKADELKFGKLNIRFQGEEGVDAGGVTREWFQVLSRQMFDPNYVLF 3773 Query: 351 TTVGND-LTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKV 527 V +D TF PN S EHL +FKF+GR++GKAL++ +LL+ +F+R+ YK ILG V Sbjct: 3774 VPVSSDRTTFHPNKLSPINDEHLPFFKFIGRIIGKALYEGRLLECYFSRAVYKRILGKPV 3833 Query: 528 TYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMDAD 638 + D+E+ DP YY++L WMLENDI+D++ TFS++ D Sbjct: 3834 SVKDMESFDPDYYKSLVWMLENDITDIITETFSVEDD 3870
>TOM1_ASHGO (Q756G2) Probable E3 ubiquitin protein ligase TOM1 (EC 6.3.2.-)| Length = 3258 Score = 205 bits (521), Expect = 1e-52 Identities = 101/215 (46%), Positives = 148/215 (68%), Gaps = 2/215 (0%) Frame = +3 Query: 3 RLLNAFIRQNSGLLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAY 182 +LLN IR N L+ FSL++K P+++DFDNKR YF ++++ H + ISVRR + Sbjct: 2851 KLLNEMIRSNPKLMSGPFSLLVKNPKILDFDNKRYYFTAQLR-AITHDRPKLSISVRREH 2909 Query: 183 ILEDSYNQLRMRSPQDLK-GRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTV 359 + DSY L +S +D+K +L + F+GE G+DAGG+TREWYQ+LSR +F+ LF V Sbjct: 2910 VFLDSYRSLFFKSNEDIKISKLEISFKGEAGVDAGGITREWYQVLSRQMFNPDYALFIPV 2969 Query: 360 GND-LTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYH 536 +D TF+PN S EHLS+FKF+G ++GKA+ D LD HF+R YK+ILG V Sbjct: 2970 ASDKTTFRPNRTSGINPEHLSFFKFIGMIIGKAISDQCFLDCHFSREVYKNILGKPVALK 3029 Query: 537 DIEAIDPAYYRNLKWMLENDISDVLDLTFSMDADE 641 D+E++D YY++L W+LENDI+D+++ TFS++ D+ Sbjct: 3030 DMESLDLDYYKSLIWILENDITDIIEETFSVETDD 3064
>TOM1_YEAST (Q03280) E3 ubiquitin protein ligase TOM1 (EC 6.3.2.-)| (Temperature-dependent organization in mitotic nucleus protein 1) (Suppressor of snRNA protein 2) Length = 3268 Score = 201 bits (510), Expect = 2e-51 Identities = 100/216 (46%), Positives = 149/216 (68%), Gaps = 3/216 (1%) Frame = +3 Query: 3 RLLNAFIRQNSGLLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDHHHSP-VRISVRRA 179 +LLN IR N L+ F+L++K P+++DFDNKR +F +K+K D+ P + I+VRR Sbjct: 2861 KLLNQMIRSNPKLMSGPFALLVKNPKVLDFDNKRYFFNAKLKS--DNQERPKLPITVRRE 2918 Query: 180 YILEDSYNQLRMRSPQDLKG-RLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTT 356 + DSY L ++ ++K +L + F+GE G+DAGG+TREWYQ+LSR +F+ LF Sbjct: 2919 QVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLP 2978 Query: 357 VGND-LTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTY 533 V +D TF PN S EHLS+FKF+G ++GKA+ D LD HF+R YK+ILG V+ Sbjct: 2979 VPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSL 3038 Query: 534 HDIEAIDPAYYRNLKWMLENDISDVLDLTFSMDADE 641 D+E++DP YY++L W+LENDI+D+++ TFS++ D+ Sbjct: 3039 KDMESLDPDYYKSLVWILENDITDIIEETFSVETDD 3074
>PTR1_SCHPO (O13834) E3 ubiquitin protein ligase ptr1 (EC 6.3.2.-) (Poly(A)+ RNA| transport protein 1) Length = 3227 Score = 197 bits (500), Expect = 3e-50 Identities = 92/215 (42%), Positives = 146/215 (67%), Gaps = 3/215 (1%) Frame = +3 Query: 3 RLLNAFIRQNSGLLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQH-DHHHSPVRISVRRA 179 +++N + L+ SFSL++K P++++F+NKR YF ++ + + P+ I+VRR Sbjct: 2818 KIINMMVFTTPSLMSGSFSLLVKNPKVLEFENKRNYFNRQLHEEAAKEQYPPLNITVRRD 2877 Query: 180 YILEDSYNQLRMRSPQDLK-GRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTT 356 ++ DSY L + ++K +L +HF+ EEG+DAGG+TREW Q+L+R +F+ LF Sbjct: 2878 HVFLDSYRALHFKDADEVKFSKLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLP 2937 Query: 357 V-GNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTY 533 V G+ TF PN +S +HLS+FKF GR++GKAL+D +LLD HF+R+ YKH+L V+ Sbjct: 2938 VTGDATTFHPNRDSSVNPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAVYKHMLHRSVSV 2997 Query: 534 HDIEAIDPAYYRNLKWMLENDISDVLDLTFSMDAD 638 DIE++DP YY++L WML NDI+D++ F+++ D Sbjct: 2998 KDIESLDPDYYKSLVWMLNNDITDIITEEFAVEKD 3032
>HUWE1_HUMAN (Q7Z6Z7) HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-)| (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1) Length = 4374 Score = 189 bits (480), Expect = 6e-48 Identities = 98/216 (45%), Positives = 148/216 (68%), Gaps = 4/216 (1%) Frame = +3 Query: 6 LLNAFIRQNSG-LLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDH-HHSPVRISVRRA 179 +LN +RQ++ L + F++++ R++DFD KR YFR +++ + + + VRR Sbjct: 3965 VLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRD 4024 Query: 180 YILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TT 356 ++ EDSY +L +SP+++K RL + F+GEEG DAGGL REWY ++SR +F+ LF T+ Sbjct: 4025 HVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTS 4084 Query: 357 VGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYH 536 G+ +T+ NP+S HLSYFKFVGR+V KA++D +LL+ +FTRSFYKHILG V Y Sbjct: 4085 PGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYT 4144 Query: 537 DIEAIDPAYYRNLKWMLENDISDV-LDLTFSMDADE 641 D+E+ D +Y+ L ++LEND+S + DLTFS + E Sbjct: 4145 DMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE 4180
>HUWE1_MOUSE (Q7TMY8) HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-)| (E3 ubiquitin protein ligase URE-B1) (E3Histone) Length = 4377 Score = 189 bits (480), Expect = 6e-48 Identities = 98/216 (45%), Positives = 148/216 (68%), Gaps = 4/216 (1%) Frame = +3 Query: 6 LLNAFIRQNSG-LLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDH-HHSPVRISVRRA 179 +LN +RQ++ L + F++++ R++DFD KR YFR +++ + + + VRR Sbjct: 3968 VLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRD 4027 Query: 180 YILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TT 356 ++ EDSY +L +SP+++K RL + F+GEEG DAGGL REWY ++SR +F+ LF T+ Sbjct: 4028 HVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTS 4087 Query: 357 VGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYH 536 G+ +T+ NP+S HLSYFKFVGR+V KA++D +LL+ +FTRSFYKHILG V Y Sbjct: 4088 PGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYT 4147 Query: 537 DIEAIDPAYYRNLKWMLENDISDV-LDLTFSMDADE 641 D+E+ D +Y+ L ++LEND+S + DLTFS + E Sbjct: 4148 DMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE 4183
>PUB3_SCHPO (O14326) E3 ubiquitin--protein ligase pub3 (EC 6.3.2.-)| Length = 786 Score = 159 bits (402), Expect = 7e-39 Identities = 87/187 (46%), Positives = 119/187 (63%), Gaps = 3/187 (1%) Frame = +3 Query: 87 DFDNKRAYFRSKIKHQHDHHHSP--VRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQ 260 DF K YFRS Q P + VRR +I EDSY ++ S DLK RL + F Sbjct: 411 DFRRKLIYFRS----QPGMRPLPGQCNVKVRRDHIFEDSYAEIMRYSAHDLKKRLMIRFD 466 Query: 261 GEEGIDAGGLTREWYQLLSRVIFDKGALLFT-TVGNDLTFQPNPNSVYQTEHLSYFKFVG 437 GE+G+D GGL+RE++ LLS +FD LF + ++ T Q NP+S EHL+YF+F+G Sbjct: 467 GEDGLDYGGLSREFFFLLSHKMFDPIYCLFEYSAVDNYTLQINPHSSINPEHLNYFRFIG 526 Query: 438 RVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDL 617 RV+G A+F + LD F S YK +L KV+ D+E+ID +YR+LKW+LENDI+ +LDL Sbjct: 527 RVIGLAIFHRRFLDAFFVVSLYKKLLRKKVSLADMESIDAEFYRSLKWVLENDITGILDL 586 Query: 618 TFSMDAD 638 TFS++ D Sbjct: 587 TFSVEED 593
>PUB1_SCHPO (Q92462) E3 ubiquitin--protein ligase pub1 (EC 6.3.2.-)| Length = 767 Score = 157 bits (398), Expect = 2e-38 Identities = 89/185 (48%), Positives = 117/185 (63%), Gaps = 3/185 (1%) Frame = +3 Query: 87 DFDNKRAYFRSKIKHQHDHHHSP--VRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQ 260 DF K YF S Q H P I VRR +I EDSY ++ +S DLK RL + F Sbjct: 392 DFRRKLIYFLS----QPALHPLPGQCHIKVRRNHIFEDSYAEIMRQSATDLKKRLMIKFD 447 Query: 261 GEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNSVYQTEHLSYFKFVG 437 GE+G+D GGL+RE++ LLS +F+ LF D T Q NP+S EHL+YFKF+G Sbjct: 448 GEDGLDYGGLSREYFFLLSHEMFNPFYCLFEYSSVDNYTLQINPHSGINPEHLNYFKFIG 507 Query: 438 RVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDL 617 RV+G A+F + +D F SFYK IL KVT D+E++D YYR+L W+L+NDI+ VLDL Sbjct: 508 RVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEYYRSLVWILDNDITGVLDL 567 Query: 618 TFSMD 632 TFS++ Sbjct: 568 TFSVE 572
>RSP5_YEAST (P39940) E3 ubiquitin--protein ligase RSP5 (EC 6.3.2.-)| Length = 809 Score = 152 bits (383), Expect = 1e-36 Identities = 87/190 (45%), Positives = 115/190 (60%), Gaps = 3/190 (1%) Frame = +3 Query: 87 DFDNKRAYFRSK--IKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQ 260 DF K YFRS+ ++ H I VRR I ED+Y ++ ++P+DLK RL + F Sbjct: 434 DFRRKVIYFRSQPALRILPGQCH----IKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFD 489 Query: 261 GEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNSVYQTEHLSYFKFVG 437 GEEG+D GG++RE++ LLS +F+ LF D T Q NPNS EHL+YFKF+G Sbjct: 490 GEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIG 549 Query: 438 RVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDL 617 RVVG +F + LD F + YK +L KV D+E +D Y +L WMLEN I VLDL Sbjct: 550 RVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGVLDL 609 Query: 618 TFSMDADEEK 647 TFS AD+E+ Sbjct: 610 TFS--ADDER 617
>NEDD4_HUMAN (P46934) E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-)| Length = 1000 Score = 150 bits (380), Expect = 2e-36 Identities = 83/192 (43%), Positives = 122/192 (63%), Gaps = 3/192 (1%) Frame = +3 Query: 72 VPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLR-MRSPQDLKGRLT 248 VP D+ K +FR K+K Q+D + + +RRA +LEDSY ++ ++ LK RL Sbjct: 616 VPYSRDYKRKYEFFRRKLKKQNDIPNK-FEMKLRRATVLEDSYRRIMGVKRADFLKARLW 674 Query: 249 VHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNS-VYQTEHLSY 422 + F GE+G+D GG+ REW+ L+S+ +F+ LF D T Q NPNS + +HLSY Sbjct: 675 IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 734 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDIS 602 FKF+GRV G A++ +LLD F R FYK +L +T HD+E++D YY +L+W+LEND + Sbjct: 735 FKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPT 794 Query: 603 DVLDLTFSMDAD 638 + LDL F +D + Sbjct: 795 E-LDLRFIIDEE 805
>NEDD4_RAT (Q62940) E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-)| Length = 887 Score = 149 bits (375), Expect = 9e-36 Identities = 80/188 (42%), Positives = 121/188 (64%), Gaps = 4/188 (2%) Frame = +3 Query: 87 DFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLR-MRSPQDLKGRLTVHFQG 263 D+ K +FR K+K Q D + + +RRA ILEDSY ++ ++ LK RL + F G Sbjct: 507 DYKRKYEFFRRKLKKQTDIPNK-FEMKLRRANILEDSYRRIMGVKRADFLKARLWIEFDG 565 Query: 264 EEGIDAGGLTREWYQLLSRVIFDK--GALLFTTVGNDLTFQPNPNS-VYQTEHLSYFKFV 434 E+G+D GG+ REW+ L+S+ +F+ G ++ ++ T Q NPNS + +HLSYFKF+ Sbjct: 566 EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATEDNYTLQINPNSGLCNEDHLSYFKFI 625 Query: 435 GRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDVLD 614 GRV G A++ +LLD F R FYK +L +T HD+E++D YY +L+W+LEND ++ LD Sbjct: 626 GRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTE-LD 684 Query: 615 LTFSMDAD 638 L F +D + Sbjct: 685 LRFIIDEE 692
>NEDD4_MOUSE (P46935) E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural| precursor cell expressed developmentally down-regulated protein 4) Length = 887 Score = 149 bits (375), Expect = 9e-36 Identities = 85/192 (44%), Positives = 120/192 (62%), Gaps = 3/192 (1%) Frame = +3 Query: 72 VPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDL-KGRLT 248 VP D+ K +FR K+K Q D + + +RRA ILEDSY ++ DL K RL Sbjct: 503 VPYSRDYKRKYEFFRRKLKKQTDIPNK-FEMKLRRANILEDSYRRIMGVKRADLLKARLW 561 Query: 249 VHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNS-VYQTEHLSY 422 + F GE+G+D GG+ REW+ L+S+ +F+ LF D T Q NPNS + +HLSY Sbjct: 562 IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 621 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDIS 602 FKF+GRV G A++ +LLD F R FYK +L +T HD+E++D YY +L+W+LEND + Sbjct: 622 FKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPT 681 Query: 603 DVLDLTFSMDAD 638 + LDL F +D + Sbjct: 682 E-LDLRFIIDEE 692
>NED4L_HUMAN (Q96PU5) E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-)| (Nedd4-2) (NEDD4.2) Length = 975 Score = 144 bits (364), Expect = 2e-34 Identities = 82/192 (42%), Positives = 119/192 (61%), Gaps = 3/192 (1%) Frame = +3 Query: 72 VPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLR-MRSPQDLKGRLT 248 VP +F K YFR K+K D + + + R I E+SY ++ ++ P LK RL Sbjct: 591 VPYSREFKQKYDYFRKKLKKPADIPNR-FEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 649 Query: 249 VHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNS-VYQTEHLSY 422 + F+ E+G+D GG+ REW+ LLS+ +F+ LF D T Q NPNS + +HLSY Sbjct: 650 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 709 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDIS 602 F F+GRV G A+F +LLD F R FYK +LG ++T +D+E++D YY +LKW+LEND + Sbjct: 710 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 769 Query: 603 DVLDLTFSMDAD 638 + LDL F +D + Sbjct: 770 E-LDLMFCIDEE 780
>NED4L_MOUSE (Q8CFI0) E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-)| (Nedd4-2) (NEDD4.2) Length = 1004 Score = 144 bits (364), Expect = 2e-34 Identities = 82/192 (42%), Positives = 119/192 (61%), Gaps = 3/192 (1%) Frame = +3 Query: 72 VPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLR-MRSPQDLKGRLT 248 VP +F K YFR K+K D + + + R I E+SY ++ ++ P LK RL Sbjct: 620 VPYSREFKQKYDYFRKKLKKPADIPNR-FEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 678 Query: 249 VHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNS-VYQTEHLSY 422 + F+ E+G+D GG+ REW+ LLS+ +F+ LF D T Q NPNS + +HLSY Sbjct: 679 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 738 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDIS 602 F F+GRV G A+F +LLD F R FYK +LG ++T +D+E++D YY +LKW+LEND + Sbjct: 739 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 798 Query: 603 DVLDLTFSMDAD 638 + LDL F +D + Sbjct: 799 E-LDLMFCIDEE 809
>NED4L_PONPY (Q5RBF2) E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-)| Length = 959 Score = 144 bits (364), Expect = 2e-34 Identities = 82/192 (42%), Positives = 119/192 (61%), Gaps = 3/192 (1%) Frame = +3 Query: 72 VPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLR-MRSPQDLKGRLT 248 VP +F K YFR K+K D + + + R I E+SY ++ ++ P LK RL Sbjct: 575 VPYSREFKQKYDYFRKKLKKPADIPNR-FEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 633 Query: 249 VHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNS-VYQTEHLSY 422 + F+ E+G+D GG+ REW+ LLS+ +F+ LF D T Q NPNS + +HLSY Sbjct: 634 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 693 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDIS 602 F F+GRV G A+F +LLD F R FYK +LG ++T +D+E++D YY +LKW+LEND + Sbjct: 694 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 753 Query: 603 DVLDLTFSMDAD 638 + LDL F +D + Sbjct: 754 E-LDLMFCIDEE 764
>SMUF2_HUMAN (Q9HAU4) Smad ubiquitination regulatory factor 2 (EC 6.3.2.-)| (Ubiquitin--protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2) Length = 748 Score = 144 bits (363), Expect = 2e-34 Identities = 82/191 (42%), Positives = 110/191 (57%), Gaps = 2/191 (1%) Frame = +3 Query: 66 LKVPRLI-DFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGR 242 L VPR D K R ++ Q RI V R I E+SY Q+ P+DL R Sbjct: 363 LTVPRYKRDLVQKLKILRQELSQQQPQA-GHCRIEVSREEIFEESYRQVMKMRPKDLWKR 421 Query: 243 LTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDL-TFQPNPNSVYQTEHLS 419 L + F+GEEG+D GG+ REW LLS + + LF +D+ T Q NP+S EHLS Sbjct: 422 LMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLS 481 Query: 420 YFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDI 599 YF FVGR++G A+F +D FT FYK +LG +T D+E +DP + +L W+LENDI Sbjct: 482 YFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDI 541 Query: 600 SDVLDLTFSMD 632 + VLD TF ++ Sbjct: 542 TGVLDHTFCVE 552
>SMUF1_XENLA (Q9PUN2) Smad ubiquitination regulatory factor 1 (EC 6.3.2.-)| (Ubiquitin--protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase) (xSMURF1) Length = 731 Score = 140 bits (352), Expect = 4e-33 Identities = 71/159 (44%), Positives = 100/159 (62%), Gaps = 1/159 (0%) Frame = +3 Query: 159 RISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKG 338 R+ V R I E+SY Q+ P+DLK RL V F+GEEG+D GG+ REW LL + + Sbjct: 374 RVEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPY 433 Query: 339 ALLFT-TVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHIL 515 LF + N T Q NP+S +HLSYF FVGR++G A+F ++ FT FYK +L Sbjct: 434 YGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLL 493 Query: 516 GAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMD 632 G + D+E++DP +++L W+LENDI+ VLD TF ++ Sbjct: 494 GKPIQLSDLESVDPELHKSLVWILENDITSVLDHTFCVE 532
>SMUF1_MOUSE (Q9CUN6) Smad ubiquitination regulatory factor 1 (EC 6.3.2.-)| (Ubiquitin--protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) Length = 731 Score = 140 bits (352), Expect = 4e-33 Identities = 72/159 (45%), Positives = 100/159 (62%), Gaps = 1/159 (0%) Frame = +3 Query: 159 RISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKG 338 RI V R I E+SY Q+ P+DLK RL V F+GEEG+D GG+ REW LL + + Sbjct: 374 RIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPY 433 Query: 339 ALLFT-TVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHIL 515 LF + N T Q NP+S +HLSYF FVGR++G A+F ++ FT FYK +L Sbjct: 434 YGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLL 493 Query: 516 GAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMD 632 G + D+E++DP +++L W+LENDI+ VLD TF ++ Sbjct: 494 GKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVE 532
>ITCH_MOUSE (Q8C863) Itchy E3 ubiquitin protein ligase (EC 6.3.2.-)| Length = 864 Score = 140 bits (352), Expect = 4e-33 Identities = 77/186 (41%), Positives = 108/186 (58%), Gaps = 2/186 (1%) Frame = +3 Query: 87 DFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGE 266 DF K YFR + H ++I+V R + EDS+ Q+ SPQDL+ RL V F GE Sbjct: 488 DFKAKVQYFRFWCQQLAMPQH--IKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGE 545 Query: 267 EGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNSVYQTEHLSYFKFVGRV 443 EG+D GG+ REW+ LLS + + LF G D Q NP S +HL YF+F+GR Sbjct: 546 EGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRF 605 Query: 444 VGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLT 620 + ALF + +D F+ FYK IL V D+E+IDP +Y +L W+ EN+I + L++ Sbjct: 606 IAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGLEMY 665 Query: 621 FSMDAD 638 FS+D + Sbjct: 666 FSVDKE 671
>ITCH_HUMAN (Q96J02) Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-)| (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) Length = 903 Score = 140 bits (352), Expect = 4e-33 Identities = 77/186 (41%), Positives = 108/186 (58%), Gaps = 2/186 (1%) Frame = +3 Query: 87 DFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGE 266 DF K YFR + H ++I+V R + EDS+ Q+ SPQDL+ RL V F GE Sbjct: 527 DFKAKVQYFRFWCQQLAMPQH--IKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGE 584 Query: 267 EGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNSVYQTEHLSYFKFVGRV 443 EG+D GG+ REW+ LLS + + LF G D Q NP S +HL YF+F+GR Sbjct: 585 EGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRF 644 Query: 444 VGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLT 620 + ALF + +D F+ FYK IL V D+E+IDP +Y +L W+ EN+I + L++ Sbjct: 645 IAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMY 704 Query: 621 FSMDAD 638 FS+D + Sbjct: 705 FSVDKE 710
>SMUF1_HUMAN (Q9HCE7) Smad ubiquitination regulatory factor 1 (EC 6.3.2.-)| (Ubiquitin--protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1) Length = 757 Score = 137 bits (346), Expect = 2e-32 Identities = 71/159 (44%), Positives = 99/159 (62%), Gaps = 1/159 (0%) Frame = +3 Query: 159 RISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKG 338 RI V R I E+SY Q+ P+DLK RL V F+GEEG+D GG+ REW LL + + Sbjct: 400 RIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPY 459 Query: 339 ALLFT-TVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHIL 515 LF + N Q NP+S +HLSYF FVGR++G A+F ++ FT FYK +L Sbjct: 460 YGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLL 519 Query: 516 GAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMD 632 G + D+E++DP +++L W+LENDI+ VLD TF ++ Sbjct: 520 GKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVE 558
>WWP1_HUMAN (Q9H0M0) NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW| domain-containing protein 1) (Atropin-1-interacting protein 5) (AIP5) Length = 922 Score = 136 bits (343), Expect = 5e-32 Identities = 75/183 (40%), Positives = 109/183 (59%), Gaps = 7/183 (3%) Frame = +3 Query: 111 FRSKIKH-----QHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGI 275 FR K+ H Q + S V+I+V R + EDS+ Q+ P DL+ RL V F+GEEG+ Sbjct: 547 FRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGL 606 Query: 276 DAGGLTREWYQLLSRVIFDKGALLFTTVG-NDLTFQPNPNSVYQTEHLSYFKFVGRVVGK 452 D GGL REW+ LLS + + LF G N+ Q NP S +HLSYF F+GR + Sbjct: 607 DYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAM 666 Query: 453 ALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLTFSM 629 ALF + +D F+ FYK +L K+T D+E+ID +Y +L W+ +N+I + L++ FS+ Sbjct: 667 ALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSV 726 Query: 630 DAD 638 D + Sbjct: 727 DME 729
>WWP1_MOUSE (Q8BZZ3) NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW| domain-containing protein 1) Length = 918 Score = 136 bits (343), Expect = 5e-32 Identities = 75/183 (40%), Positives = 109/183 (59%), Gaps = 7/183 (3%) Frame = +3 Query: 111 FRSKIKH-----QHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGI 275 FR K+ H Q + S V+I+V R + EDS+ Q+ P DL+ RL V F+GEEG+ Sbjct: 543 FRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGL 602 Query: 276 DAGGLTREWYQLLSRVIFDKGALLFTTVG-NDLTFQPNPNSVYQTEHLSYFKFVGRVVGK 452 D GGL REW+ LLS + + LF G N+ Q NP S +HLSYF F+GR + Sbjct: 603 DYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAM 662 Query: 453 ALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLTFSM 629 ALF + +D F+ FYK +L K+T D+E+ID +Y +L W+ +N+I + L++ FS+ Sbjct: 663 ALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSV 722 Query: 630 DAD 638 D + Sbjct: 723 DME 725
>SMUF1_DROME (Q9V853) E3 ubiquitin-protein ligase Smurf1 (EC 6.3.2.-) (Smad| ubiquitination regulatory factor 1 homolog) (DSmurf) (Lethal with a checkpoint kinase protein) Length = 1061 Score = 136 bits (342), Expect = 6e-32 Identities = 71/159 (44%), Positives = 99/159 (62%), Gaps = 1/159 (0%) Frame = +3 Query: 159 RISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKG 338 R+ V R I E+SY + +D++ RL V F+GEEG+D GG+ REW LLSR + + Sbjct: 703 RLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQ 762 Query: 339 ALLFTTVGND-LTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHIL 515 LF +D T Q NP+S +HLSYF FVGR +G A+F LD FT FYK +L Sbjct: 763 YGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLL 822 Query: 516 GAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMD 632 +T DIE +DP +R+L WMLE++IS +++ TFS++ Sbjct: 823 NKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVE 861
>NEDD4_DROME (Q9VVI3) E3 ubiquitin-protein ligase Nedd-4 (EC 6.3.2.-) (DNedd4)| Length = 1007 Score = 136 bits (342), Expect = 6e-32 Identities = 77/192 (40%), Positives = 113/192 (58%), Gaps = 3/192 (1%) Frame = +3 Query: 72 VPRLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDL-KGRLT 248 VP D+ K YF+S I+ + + + I +RR ILEDSY + + DL K +L Sbjct: 623 VPYSRDYKQKYEYFKSHIR-KPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLW 681 Query: 249 VHFQGEEGIDAGGLTREWYQLLSRVIFDK--GALLFTTVGNDLTFQPNPNSVYQTEHLSY 422 V F+GE G+D GGL REW+ LLS+ +F+ G ++ + N N + + EHLSY Sbjct: 682 VEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSY 741 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDIS 602 FKF+GR+ G A++ +LLD F R FYK +L + D+E++D YY +L W+ END Sbjct: 742 FKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-P 800 Query: 603 DVLDLTFSMDAD 638 +L+LTF +D D Sbjct: 801 RILELTFCLDED 812
>HUWE1_RAT (P51593) HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-)| (E3 ubiquitin protein ligase URE-B1) (Upstream regulatory element-binding protein 1) (Fragment) Length = 322 Score = 133 bits (334), Expect = 5e-31 Identities = 68/128 (53%), Positives = 92/128 (71%), Gaps = 2/128 (1%) Frame = +3 Query: 264 EEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNDLTFQPNPNSVYQTEHLSYFKFVGR 440 EEG DAGGL REWY ++SR +F+ LF T+ G+ +T+ NP+S HLSYFKFVGR Sbjct: 1 EEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 60 Query: 441 VVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDL 617 +V KA++D +LL+ +FTRSFYKHILG V Y D+E+ D +Y+ L ++LEND+S + DL Sbjct: 61 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDL 120 Query: 618 TFSMDADE 641 TFS + E Sbjct: 121 TFSTEVQE 128
>WWP2_MOUSE (Q9DBH0) NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW| domain-containing protein 2) Length = 870 Score = 132 bits (331), Expect = 1e-30 Identities = 66/165 (40%), Positives = 100/165 (60%), Gaps = 2/165 (1%) Frame = +3 Query: 150 SPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIF 329 S V+ISV R + EDS+ Q+ P DL+ RL + +GEEG+D GG+ REW+ LLS + Sbjct: 513 SHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVL 572 Query: 330 DKGALLFTTVG-NDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYK 506 + LF G N+ Q NP S +HL+YF+F+GR + AL+ + +D FT FYK Sbjct: 573 NPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYK 632 Query: 507 HILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLTFSMDAD 638 +L + T D+E+IDP +Y ++ W+ EN++ + L+L F D + Sbjct: 633 RMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDME 677
>WWP2_HUMAN (O00308) NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW| domain-containing protein 2) (Atrophin-1-interacting protein 2) (AIP2) Length = 870 Score = 132 bits (331), Expect = 1e-30 Identities = 66/165 (40%), Positives = 100/165 (60%), Gaps = 2/165 (1%) Frame = +3 Query: 150 SPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIF 329 S V+ISV R + EDS+ Q+ P DL+ RL + +GEEG+D GG+ REW+ LLS + Sbjct: 513 SHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVL 572 Query: 330 DKGALLFTTVG-NDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYK 506 + LF G N+ Q NP S +HL+YF+F+GR + AL+ + +D FT FYK Sbjct: 573 NPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYK 632 Query: 507 HILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLTFSMDAD 638 +L + T D+E+IDP +Y ++ W+ EN++ + L+L F D + Sbjct: 633 RMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME 677
>SUDX_DROME (Q9Y0H4) E3 ubiquitin-protein ligase suppressor of deltex (EC| 6.3.2.-) Length = 949 Score = 130 bits (327), Expect = 3e-30 Identities = 67/163 (41%), Positives = 101/163 (61%), Gaps = 2/163 (1%) Frame = +3 Query: 150 SPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIF 329 S ++I+V R + EDSY+Q+ +L+ RL + F+GEEG+D GG++REW+ LLS + Sbjct: 592 SHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVL 651 Query: 330 DKGALLFTTVG-NDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYK 506 + LF N+ + Q NP S +HL YFKF+GR + AL+ + + FT FYK Sbjct: 652 NPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYK 711 Query: 507 HILGAKVTYHDIEAIDPAYYRNLKWMLENDISDV-LDLTFSMD 632 +L K+T DIE IDP +Y +L W+ +N+I + L+L FS+D Sbjct: 712 RMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVD 754
>PUB2_SCHPO (Q9UTG2) E3 ubiquitin--protein ligase pub2 (EC 6.3.2.-)| Length = 671 Score = 123 bits (309), Expect = 4e-28 Identities = 64/180 (35%), Positives = 106/180 (58%), Gaps = 6/180 (3%) Frame = +3 Query: 111 FRSKIKHQHDH-----HHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGI 275 ++ KI + +D + + +++ V RA ED+Y+ + S D+K +L + F+ E+G+ Sbjct: 297 YQRKIAYMYDRPEMAVNDAQLQLKVSRATTFEDAYDIISKLSVSDMKKKLLIRFRNEDGL 356 Query: 276 DAGGLTREWYQLLSRVIFDKGALLFTTVGND-LTFQPNPNSVYQTEHLSYFKFVGRVVGK 452 D GG++RE++ +LS IF+ G LF +D Q +P S + SYF+FVGRV+G Sbjct: 357 DYGGVSREFFYILSHAIFNPGYSLFEYATDDNYGLQISPLSSVNPDFRSYFRFVGRVMGL 416 Query: 453 ALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMD 632 A++ + LDV F FYK IL + D++ +D YY +LKW+ ND+ + L L FS++ Sbjct: 417 AIYHRRYLDVQFVLPFYKRILQKPLCLEDVKDVDEVYYESLKWIKNNDVDESLCLNFSVE 476
>K0317_MOUSE (Q8CHG5) Protein KIAA0317| Length = 823 Score = 102 bits (253), Expect = 1e-21 Identities = 65/190 (34%), Positives = 101/190 (53%), Gaps = 11/190 (5%) Frame = +3 Query: 90 FDNKRAYFRSKIKHQH-DHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGE 266 F +K +F+ +++ H HS V + V R +LE S R S D V FQ E Sbjct: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDE 498 Query: 267 EGIDAGGLTREWYQLLSRVIFDKGALLFT--TVGNDLTFQPNPNSVYQTEHLSYFKFVGR 440 E +D GG REW++L+ + +FD + LF T N PNPN L ++F GR Sbjct: 499 EALDWGGPRREWFELICKALFDTTSQLFARFTDSNQALVHPNPNRPAHL-RLKMYEFAGR 557 Query: 441 VVGKALFDA-------QLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRN-LKWMLEND 596 +VGK L+++ QL+ FTRSF I+G ++ Y E DP +Y++ + ++L ND Sbjct: 558 LVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNND 617 Query: 597 ISDVLDLTFS 626 +S+ ++L F+ Sbjct: 618 MSE-MELVFA 626
>UBE3A_HUMAN (Q05086) Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP| ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen) Length = 875 Score = 101 bits (252), Expect = 2e-21 Identities = 58/163 (35%), Positives = 101/163 (61%), Gaps = 5/163 (3%) Frame = +3 Query: 156 VRISVRRAYILEDSYNQLRM---RSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVI 326 +R+ VRR +I++D+ +L M +P DLK +L V F+GE+G+D GG+++E++QL+ I Sbjct: 523 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 582 Query: 327 FDKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYK 506 F+ +FT + F NP+S ++TE F +G V+G A+++ +LDVHF Y+ Sbjct: 583 FNPDIGMFTYDESTKLFWFNPSS-FETE--GQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639 Query: 507 HILGAKVTYHDIEAIDPAYYRNLKWML--ENDISDVLDLTFSM 629 ++G K T+ D+ P Y++LK +L E ++ D + +TF + Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQI 682
>K0317_HUMAN (O15033) Protein KIAA0317| Length = 823 Score = 101 bits (251), Expect = 2e-21 Identities = 65/190 (34%), Positives = 101/190 (53%), Gaps = 11/190 (5%) Frame = +3 Query: 90 FDNKRAYFRSKIKHQH-DHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGE 266 F +K +F+ +++ H HS V + V R +LE S R S D V FQ E Sbjct: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDE 498 Query: 267 EGIDAGGLTREWYQLLSRVIFDKGALLFT--TVGNDLTFQPNPNSVYQTEHLSYFKFVGR 440 E +D GG REW++L+ + +FD LFT + N PNPN L ++F GR Sbjct: 499 EALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHL-RLKMYEFAGR 557 Query: 441 VVGKALFDA-------QLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRN-LKWMLEND 596 +VGK L+++ QL+ FTRSF I+G ++ Y E DP +Y++ + ++L ND Sbjct: 558 LVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNND 617 Query: 597 ISDVLDLTFS 626 +S+ ++L F+ Sbjct: 618 MSE-MELVFA 626
>UBE3A_MOUSE (O08759) Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic| protein-associated protein E6-AP) Length = 885 Score = 94.0 bits (232), Expect = 4e-19 Identities = 56/161 (34%), Positives = 97/161 (60%), Gaps = 5/161 (3%) Frame = +3 Query: 162 ISVRRAYILEDSYNQLRM---RSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFD 332 + VRR +I++D+ +L M +P DLK +L V F+GE+G+D GG+++E++QL+ IF+ Sbjct: 536 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 595 Query: 333 KGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHI 512 +FT F NP+S ++TE F +G ++G A+++ +LDVHF Y+ + Sbjct: 596 PDIGMFTYDEATKLFWFNPSS-FETE--GQFTLIG-ILGLAIYNNCILDVHFPMVVYRKL 651 Query: 513 LGAKVTYHDIEAIDPAYYRNLKWML--ENDISDVLDLTFSM 629 +G K T+ D+ P Y++LK +L E + D + +TF + Sbjct: 652 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQI 692
>UBE3C_MOUSE (Q80U95) Ubiquitin-protein ligase E3C (EC 6.3.2.-)| Length = 1083 Score = 90.5 bits (223), Expect = 4e-18 Identities = 63/212 (29%), Positives = 109/212 (51%), Gaps = 17/212 (8%) Frame = +3 Query: 45 EKSFSLMLKVPRLIDFDNKRAYFRSKI--KHQHDHHHSP----VRISVRRAYILEDSYNQ 206 E+ +++ ++P ++ F+ + F+ I Q P + +++RR YI ED+Y++ Sbjct: 680 ERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDK 739 Query: 207 LRMRSPQDLKGRLTVHFQG-----EEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDL 371 L + DLK R+ VH E GID GG+ RE+ L + F+ F T L Sbjct: 740 LSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGL 799 Query: 372 TFQPNP--NSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILG--AKVTYHD 539 + PNP + ++ F+GR++GKAL++ L+++ F F +LG A V H Sbjct: 800 LY-PNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHH 858 Query: 540 IEAIDPAYYRNLKWM--LENDISDVLDLTFSM 629 + ++DP YRNL ++ E D+ + L L F++ Sbjct: 859 LASLDPEVYRNLLFLKSYEEDVEE-LGLNFTV 889
>UBE3C_HUMAN (Q15386) Ubiquitin-protein ligase E3C (EC 6.3.2.-)| Length = 1083 Score = 89.4 bits (220), Expect = 9e-18 Identities = 62/212 (29%), Positives = 110/212 (51%), Gaps = 17/212 (8%) Frame = +3 Query: 45 EKSFSLMLKVPRLIDFDNKRAYFRSKI--KHQHDHHHSP----VRISVRRAYILEDSYNQ 206 E+ +++ ++P ++ F+ + F+ I Q P + +++RR YI ED+Y++ Sbjct: 680 ERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDK 739 Query: 207 LRMRSPQDLKGRLTVHFQG-----EEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDL 371 L + DLK R+ VH E GID GG+ RE+ L + F+ F T L Sbjct: 740 LSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGL 799 Query: 372 TFQPNP--NSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILG--AKVTYHD 539 + PNP + ++ F+GR++GKAL++ L+++ F F +LG A V H Sbjct: 800 LY-PNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHH 858 Query: 540 IEAIDPAYYRNLKWM--LENDISDVLDLTFSM 629 + ++DP Y+NL ++ E+D+ + L L F++ Sbjct: 859 LASLDPEVYKNLLFLKSYEDDVEE-LGLNFTV 889
>HUL4_ASHGO (Q757T0) Probable ubiquitin-protein ligase HUL4 (EC 6.3.2.-) (HECT| ubiquitin ligase 4) Length = 839 Score = 85.5 bits (210), Expect = 1e-16 Identities = 65/208 (31%), Positives = 109/208 (52%), Gaps = 18/208 (8%) Frame = +3 Query: 54 FSLMLKVP-------RLIDFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLR 212 FSL +K+ RL+++ ++A+ ++ + Q + ++I VRR ++ DS ++ Sbjct: 438 FSLGMKISILEYETRRLMEYSAEQAFLKALDRKQVVDVY--LKIRVRREFVTTDSLRSIQ 495 Query: 213 MRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGND-----LTF 377 + +DLK L + F E GIDAGGL +EW+ LL+R +F+ LF V Sbjct: 496 NQQ-KDLKKSLRIEFVNEPGIDAGGLRKEWFLLLTRDLFNPNNGLFVYVPESRLCWFSIM 554 Query: 378 QPNPNSVYQTEHLS---YFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEA 548 + + + Q E S Y+ F G V+G A++++ +LD+ F R+FYK I G ++ +D Sbjct: 555 ESIEHELLQGEGSSSELYYLF-GVVLGLAIYNSTILDLKFPRAFYKKICGEVLSVNDFLE 613 Query: 549 IDPAYYRNLKWMLE---NDISDVLDLTF 623 + P N+ MLE D D+ LTF Sbjct: 614 LYPETGTNMLKMLEYDGEDFEDIFALTF 641
>HUL4_YEAST (P40985) Probable ubiquitin-protein ligase HUL4 (EC 6.3.2.-) (HECT| ubiquitin ligase 4) Length = 892 Score = 78.2 bits (191), Expect = 2e-14 Identities = 52/164 (31%), Positives = 83/164 (50%), Gaps = 9/164 (5%) Frame = +3 Query: 159 RISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFD-- 332 +I VRR I DS ++ LK L + F E GIDAGGL +EW+ LL++ +F+ Sbjct: 522 KIKVRRDVISHDSLRCIKEHQGDLLKS-LRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPM 580 Query: 333 KGALLFTTVGNDLTFQPNP----NSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSF 500 G ++ + F +P S + L + G V+G A+F++ +LD+ F ++ Sbjct: 581 NGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKAL 640 Query: 501 YKHILGAKVTYHDIEAIDPAYYRNLKWML---ENDISDVLDLTF 623 YK + +++ D + P RNL ML E++ DV LTF Sbjct: 641 YKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTF 684
>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3| Length = 1050 Score = 77.0 bits (188), Expect = 5e-14 Identities = 48/161 (29%), Positives = 87/161 (54%), Gaps = 5/161 (3%) Frame = +3 Query: 162 ISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDK-- 335 + VRR ++ D+ +L + S DLK L V F GEE +DAGG+T+E++ LL + + + Sbjct: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIY 763 Query: 336 GALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHIL 515 G + N L F + EH ++F +G G A++++ ++D+HF + YK +L Sbjct: 764 GMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLL 818 Query: 516 GAKVTYHDIEAIDPAYYRNLKWMLE---NDISDVLDLTFSM 629 K D++ + P R+L+ +L+ D+ + L F++ Sbjct: 819 NVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTI 859
>HUL5_YEAST (P53119) Probable ubiquitin-protein ligase HUL5 (EC 6.3.2.-)| Length = 910 Score = 73.9 bits (180), Expect = 4e-13 Identities = 68/235 (28%), Positives = 104/235 (44%), Gaps = 29/235 (12%) Frame = +3 Query: 24 RQNSGLLEKSFSLMLKVPRLIDFDNKRAYFR-----SKIKHQHDHHHSPVRIS------- 167 R S L + ++L++P I F+ + F K + D H+ + + Sbjct: 491 RLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTG 550 Query: 168 -------VRRAYILEDSYNQLRM---RSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLS 317 + R +LED++N R L F E GID GG+T+E+ +S Sbjct: 551 MRKQSAIISRDNVLEDAFNAFNSIGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVS 610 Query: 318 RVIF-DKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTR 494 F D LF T ND ++ P+ VY L Y F+G+VVGK L++ L+DV F Sbjct: 611 DEGFKDPKHELFRT--ND-RYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFAD 667 Query: 495 SFYKHIL----GAKVTYHDIEAIDPAYYRNLKWMLENDISDV--LDLTFSMDADE 641 F K +L G ++ D+ + D Y NL +L ++ LDLTF +D E Sbjct: 668 FFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPE 722
>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5| (Cyclin-E-binding protein 1) Length = 1024 Score = 67.0 bits (162), Expect = 5e-11 Identities = 48/186 (25%), Positives = 92/186 (49%), Gaps = 8/186 (4%) Frame = +3 Query: 63 MLKVPRLIDFDNKR--AYFRSKIKHQHDHHHSPVR----ISVRRAYILEDSYNQLRMRSP 224 +L L+ ++K+ AY RS + +R ++VRR +++ED NQL Sbjct: 644 LLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFEN 703 Query: 225 QDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIF--DKGALLFTTVGNDLTFQPNPNSV 398 +DL+ L V F GE G D GG+ +E++ L + + G ++ + + F P Sbjct: 704 EDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKP--- 760 Query: 399 YQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLK 578 + E YF F G + G +LF+ + ++ F + +K +L + D++ + P +NL+ Sbjct: 761 -KFEKKRYF-FFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQ 818 Query: 579 WMLEND 596 +L+++ Sbjct: 819 TLLDDE 824
>HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (Protein| hyperplastic discs) Length = 2885 Score = 52.0 bits (123), Expect = 2e-06 Identities = 21/62 (33%), Positives = 38/62 (61%) Frame = +3 Query: 408 EHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVTYHDIEAIDPAYYRNLKWML 587 E ++ F+ +GR++G L +LL + R K+ILG K+ +HD+ DPA Y + + ++ Sbjct: 2610 ERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQII 2669 Query: 588 EN 593 +N Sbjct: 2670 QN 2671
>EDD1_HUMAN (O95071) Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic| discs protein homolog) (hHYD) (Progestin-induced protein) Length = 2799 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 7/113 (6%) Frame = +3 Query: 330 DKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKH 509 D A LF G + P P + L+ F+ +GR++G L +L + R K Sbjct: 2499 DDNAPLFYQPGKRGFYTPRPGKNTEAR-LNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2557 Query: 510 ILGAKVTYHDIEAIDPAYYRNLKWML-------ENDISDVLDLTFSMDADEEK 647 +LG KV +HD DP Y +L+ ++ + + +DL F++D +E+ Sbjct: 2558 LLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEE 2610
>EDD1_MOUSE (Q80TP3) Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic| discs protein homolog) Length = 2792 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 7/113 (6%) Frame = +3 Query: 330 DKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKH 509 D A LF G + P P + L+ F+ +GR++G L +L + R K Sbjct: 2492 DDNAPLFYQPGKRGFYTPRPGKNTEAR-LNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2550 Query: 510 ILGAKVTYHDIEAIDPAYYRNLKWML-------ENDISDVLDLTFSMDADEEK 647 +LG KV +HD DP Y +L+ ++ + + +DL F++D +E+ Sbjct: 2551 LLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEE 2603
>EDD1_RAT (Q62671) Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic| discs protein homolog) (100 kDa protein) (Fragment) Length = 920 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 7/113 (6%) Frame = +3 Query: 330 DKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKH 509 D A LF G + P P + L+ F+ +GR++G L +L + R K Sbjct: 620 DDNAPLFYQPGKRGFYTPRPGKNTEAR-LNCFRNIGRILGLCLLQNELCPITLNRHVIKV 678 Query: 510 ILGAKVTYHDIEAIDPAYYRNLKWML-------ENDISDVLDLTFSMDADEEK 647 +LG KV +HD DP Y +L+ ++ + + +DL F++D +E+ Sbjct: 679 LLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEE 731
>TRIPC_HUMAN (Q14669) Thyroid receptor-interacting protein 12 (TRIP12)| Length = 1992 Score = 38.5 bits (88), Expect = 0.018 Identities = 19/53 (35%), Positives = 33/53 (62%), Gaps = 2/53 (3%) Frame = +3 Query: 423 FKFVGRVVGKALFDAQLLDVHFTRSFYKHIL--GAKVTYHDIEAIDPAYYRNL 575 F+F+G+++ KA+ D +L+D+ FYK +L +T HD+ IDP R++ Sbjct: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSV 1749
>AUTS2_HUMAN (Q8WXX7) Autism susceptibility gene 2 protein| Length = 1259 Score = 32.0 bits (71), Expect = 1.7 Identities = 23/79 (29%), Positives = 31/79 (39%), Gaps = 19/79 (24%) Frame = +3 Query: 66 LKVPRLIDFDNKRAYFRSK----IKHQHDHHHSPVRISVR-------------RAYILED 194 L PRL + D FR + H H HHH P+ + R R ++L + Sbjct: 1104 LSTPRLYEADRS---FRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHMLRE 1160 Query: 195 SYNQLRMRS--PQDLKGRL 245 Y R+ S P L G L Sbjct: 1161 DYEHTRLHSVHPASLDGHL 1179
>FOXGB_CHICK (Q90964) Forkhead box protein G1B (Forkhead-related protein FKHL1)| (Transcription factor BF-1) (Brain factor 1) (BF1) (CBF-1) (Proto-oncogene C-QIN) (N-62-5) (CEQ 3-1) Length = 451 Score = 30.4 bits (67), Expect = 4.9 Identities = 13/37 (35%), Positives = 17/37 (45%) Frame = +3 Query: 39 LLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDHHH 149 L + SFS+ VP + DN + H H HHH Sbjct: 13 LPKSSFSINSLVPEAVQSDNHSGHSHHNSHHPHHHHH 49
>MURB_WOLPM (Q73HL4) UDP-N-acetylenolpyruvoylglucosamine reductase (EC| 1.1.1.158) (UDP-N-acetylmuramate dehydrogenase) Length = 295 Score = 30.4 bits (67), Expect = 4.9 Identities = 15/45 (33%), Positives = 27/45 (60%) Frame = -2 Query: 620 CEVQDITYVILEHPLQVSVVSRINGFNIMVSNLGTKYVLVERSSE 486 C+++D+TY+I L VSV+ + NI+V + G + + V+ E Sbjct: 37 CDIEDLTYLIKNTELPVSVIGATS--NIIVRDSGIRGITVKLGKE 79
>QIN_AVIS3 (P56260) Transforming protein Qin (Oncogene Qin)| Length = 387 Score = 30.0 bits (66), Expect = 6.3 Identities = 13/37 (35%), Positives = 17/37 (45%) Frame = +3 Query: 39 LLEKSFSLMLKVPRLIDFDNKRAYFRSKIKHQHDHHH 149 L + SFS+ VP + DN + H H HHH Sbjct: 13 LPKSSFSINNLVPEAVQSDNHSGHSHHNSHHPHHHHH 49
>SUIS_RAT (P23739) Sucrase-isomaltase, intestinal [Contains: Sucrase (EC| 3.2.1.48); Isomaltase (EC 3.2.1.10)] Length = 1840 Score = 30.0 bits (66), Expect = 6.3 Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%) Frame = +3 Query: 336 GALLFTTVGNDLTFQPNPNSVYQT--EHLSYFKFVG 437 G LL + G D+TFQP P Y+T L ++ F+G Sbjct: 1168 GVLLLNSNGMDVTFQPTPALTYRTIGGILDFYMFLG 1203
>FER3_MAIZE (P27788) Ferredoxin-3, chloroplast precursor (Ferredoxin III) (Fd| III) Length = 152 Score = 30.0 bits (66), Expect = 6.3 Identities = 21/71 (29%), Positives = 35/71 (49%) Frame = +3 Query: 351 TTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKHILGAKVT 530 T +GN T Q + +V LS+F V +V +L ++ LDV + ++G + Sbjct: 11 TLLGNVRTTQASQTAVKSPSSLSFFSQVTKV--PSLKTSKKLDVSAMAVYKVKLVGPEGE 68 Query: 531 YHDIEAIDPAY 563 H+ +A D AY Sbjct: 69 EHEFDAPDDAY 79
>YL174_MIMIV (Q5UPP1) Hypothetical protein L174| Length = 332 Score = 30.0 bits (66), Expect = 6.3 Identities = 22/85 (25%), Positives = 39/85 (45%) Frame = -2 Query: 656 QYQLLFICIHAKCEVQDITYVILEHPLQVSVVSRINGFNIMVSNLGTKYVLVERSSEMDI 477 QY + ICI++ C I ++++ L+ +N FN +V L T ++ V+ S Sbjct: 97 QYAIDDICINSAC-YDKIYKILIDKSLETD---NLNLFNFIVKELDTVFMDVDESKLTFR 152 Query: 476 QKLGIKESFSNHSSNKFEI*EVFSL 402 QK + + HS N I + + Sbjct: 153 QKNRLDSIKNKHSYNSTRINSIIKI 177
>SWI6_YEAST (P09959) Regulatory protein SWI6 (Cell-cycle box factor, chain| SWI6) (Trans-acting activator of HO endonuclease gene) (MBF subunit P90) Length = 803 Score = 30.0 bits (66), Expect = 6.3 Identities = 11/37 (29%), Positives = 25/37 (67%) Frame = +1 Query: 349 SRQLEMT*HFNQTLTLCIRLNTSHISNLLDEWLEKLS 459 ++Q E+ F + L+LC++++ + + N+LD L+ +S Sbjct: 746 TKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQAIS 782
>MPAO1_ORYSA (Q40638) Major pollen allergen Ory s 1 precursor (Ory s I)| Length = 263 Score = 29.6 bits (65), Expect = 8.3 Identities = 29/105 (27%), Positives = 44/105 (41%) Frame = +3 Query: 330 DKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDAQLLDVHFTRSFYKH 509 DK AL+ T ND P + Y + LS + L A ++D F R K+ Sbjct: 108 DKPALIHVTDMND-----EPIAAYHFD-LSGLAMAKDGKDEELRKAGIIDTQFRRVKCKY 161 Query: 510 ILGAKVTYHDIEAIDPAYYRNLKWMLENDISDVLDLTFSMDADEE 644 K+T+H +A +P Y L + D DV+++ EE Sbjct: 162 PADTKITFHIEKASNPNYLALLVKYVAGD-GDVVEVEIKEKGSEE 205 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 93,414,023 Number of Sequences: 219361 Number of extensions: 1899288 Number of successful extensions: 5032 Number of sequences better than 10.0: 57 Number of HSP's better than 10.0 without gapping: 4682 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4940 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6257125380 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
