ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags33o06 |
|---|---|
| Clone Library Name | barley_pub |
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 189 bits (480), Expect = 6e-48 Identities = 98/218 (44%), Positives = 137/218 (62%), Gaps = 2/218 (0%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G R L D +VAVK + S QG EF E+ +GYC+E ++ IL Sbjct: 608 GSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQIL 667 Query: 183 VYEYMENGTVKSHLYG--SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 VY +M NG++ LYG S L+W RL I +GAARGL YLHT +++IHRDVKS+N Sbjct: 668 VYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSN 727 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGV 536 ILLD+++ AKVADFG SK P+ ++VS V+G+ GYLDPEY++ QQL+EKSDV+SFGV Sbjct: 728 ILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGV 787 Query: 537 VMLEVLCARPVIDPSLPREMVNLAEWGMKWQKRGELHQ 650 V+LE++ R ++ PR +L EW + + ++ + Sbjct: 788 VLLEIVSGREPLNIKRPRIEWSLVEWAKPYIRASKVDE 825
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 187 bits (476), Expect = 2e-47 Identities = 97/218 (44%), Positives = 136/218 (62%), Gaps = 2/218 (0%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G R L D +VAVK + S QG EF E+ +GYC+E ++ IL Sbjct: 607 GSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQIL 666 Query: 183 VYEYMENGTVKSHLYG--SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 VY +M NG++ LYG + L+W RL I +GAARGL YLHT +++IHRDVKS+N Sbjct: 667 VYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSN 726 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGV 536 ILLD ++ AKVADFG SK P+ ++VS V+G+ GYLDPEY++ QQL+EKSDV+SFGV Sbjct: 727 ILLDHSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGV 786 Query: 537 VMLEVLCARPVIDPSLPREMVNLAEWGMKWQKRGELHQ 650 V+LE++ R ++ PR +L EW + + ++ + Sbjct: 787 VLLEIVSGREPLNIKRPRVEWSLVEWAKPYIRASKVDE 824
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 175 bits (443), Expect = 1e-43 Identities = 95/212 (44%), Positives = 130/212 (61%), Gaps = 5/212 (2%) Frame = +3 Query: 24 LRDDTKVAVKRGNPKS--QQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYM 197 LRD T VAVKR S ++ EF E++ +GYC++ +E +LVYE+M Sbjct: 524 LRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFM 583 Query: 198 ENGTVKSHLYGSD---NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLD 368 +G++ HL+G D LNW +R+ I + AARG+ YLH + +IHRD+KS+NIL+D Sbjct: 584 AHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILID 643 Query: 369 ENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLE 548 E+ A+VADFGLS GP T +S G+ GYLDPEY+R LT KSDVYSFGVV+LE Sbjct: 644 EDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLE 703 Query: 549 VLCARPVIDPSLPREMVNLAEWGMKWQKRGEL 644 +L R ID + E N+ EW + K G++ Sbjct: 704 ILSGRKAID--MQFEEGNIVEWAVPLIKAGDI 733
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 172 bits (437), Expect = 6e-43 Identities = 87/181 (48%), Positives = 117/181 (64%) Frame = +3 Query: 39 KVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKS 218 +VAVK + +S QG EFR E++ +GYC+E N M+L+YEYM N + Sbjct: 597 QVAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGD 656 Query: 219 HLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADF 398 +L G + L+W++RL+I + AA+GL YLH G I+HRDVK NILL+E L AK+ADF Sbjct: 657 YLAGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADF 716 Query: 399 GLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDP 578 GLS++ +ST V GS GYLDPEY+ +Q+ EKSDVYS GVV+LEV+ +P I Sbjct: 717 GLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQPAIAS 776 Query: 579 S 581 S Sbjct: 777 S 777
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 166 bits (420), Expect = 6e-41 Identities = 86/196 (43%), Positives = 120/196 (61%), Gaps = 2/196 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D VA+K+ + QG+ EF E+ IG+C E ++ +LVYEYM G++ Sbjct: 126 DQVVAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSL 185 Query: 213 KSHLY--GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAK 386 + HL+ S L+W R++I GAARGL YLH +I+RD+K +NILL E+ K Sbjct: 186 EDHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPK 245 Query: 387 VADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARP 566 ++DFGL+K GP D+THVST V G++GY P+Y QLT KSD+YSFGVV+LE++ R Sbjct: 246 LSDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRK 305 Query: 567 VIDPSLPREMVNLAEW 614 ID + R+ NL W Sbjct: 306 AIDNTKTRKDQNLVGW 321
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 165 bits (417), Expect = 1e-40 Identities = 86/193 (44%), Positives = 118/193 (61%), Gaps = 2/193 (1%) Frame = +3 Query: 42 VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSH 221 VAVK+ + QG EF E+ IGYC + ++ +LVYE+M G+++ H Sbjct: 112 VAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDH 171 Query: 222 LYG--SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 L+ D +L+W R++I GAA+GL +LH + +I+RD KS+NILLDE K++D Sbjct: 172 LHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSD 231 Query: 396 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 FGL+K GP D++HVST V G++GY PEY QLT KSDVYSFGVV LE++ R ID Sbjct: 232 FGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAID 291 Query: 576 PSLPREMVNLAEW 614 +P NL W Sbjct: 292 SEMPHGEQNLVAW 304
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 162 bits (409), Expect = 1e-39 Identities = 86/193 (44%), Positives = 119/193 (61%), Gaps = 2/193 (1%) Frame = +3 Query: 42 VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSH 221 +AVK+ N QG E+ E+ IGYC E +LVYE+M G++++H Sbjct: 103 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENH 162 Query: 222 LY--GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 L+ G L+WK RL++ +GAA+GL +LH+ + +I+RD K++NILLD AK++D Sbjct: 163 LFRRGLYFQPLSWKLRLKVALGAAKGLAFLHSSETR-VIYRDFKTSNILLDSEYNAKLSD 221 Query: 396 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 FGL+K GP D++HVST V G+ GY PEY LT KSDVYSFGVV+LE+L R +D Sbjct: 222 FGLAKDGPIGDKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRRAVD 281 Query: 576 PSLPREMVNLAEW 614 + P NL EW Sbjct: 282 KNRPSGERNLVEW 294
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 160 bits (406), Expect = 2e-39 Identities = 81/191 (42%), Positives = 123/191 (64%) Frame = +3 Query: 42 VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSH 221 VA+KR N +S QG E+R+E+ +GYC E E++LVYE+M G+++SH Sbjct: 121 VAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESH 180 Query: 222 LYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFG 401 L+ ++P W R++I IGAARGL +LH+ + +I+RD K++NILLD N AK++DFG Sbjct: 181 LFRRNDP-FPWDLRIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFG 238 Query: 402 LSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPS 581 L+K GP +++HV+T + G++GY PEY L KSDV++FGVV+LE++ + Sbjct: 239 LAKLGPADEKSHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTK 298 Query: 582 LPREMVNLAEW 614 PR +L +W Sbjct: 299 RPRGQESLVDW 309
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 160 bits (405), Expect = 3e-39 Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 2/193 (1%) Frame = +3 Query: 42 VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSH 221 +AVK+ N QG E+ E+ IGYC E +LVYE+M G++++H Sbjct: 104 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENH 163 Query: 222 LY--GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 L+ GS L+W RL++ +GAA+GL +LH ++I+RD K++NILLD AK++D Sbjct: 164 LFRRGSYFQPLSWTLRLKVALGAAKGLAFLHNAET-SVIYRDFKTSNILLDSEYNAKLSD 222 Query: 396 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 FGL+K GP D++HVST + G++GY PEY LT KSDVYS+GVV+LEVL R +D Sbjct: 223 FGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRRAVD 282 Query: 576 PSLPREMVNLAEW 614 + P L EW Sbjct: 283 KNRPPGEQKLVEW 295
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 160 bits (405), Expect = 3e-39 Identities = 85/202 (42%), Positives = 121/202 (59%), Gaps = 5/202 (2%) Frame = +3 Query: 24 LRDDTKVAVKR--GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYM 197 L D TK+AVKR + +G EF++EI +GYC + NE +LVYEYM Sbjct: 607 LHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYM 666 Query: 198 ENGTVKSHLYGSDNPSLN---WKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLD 368 GT+ HL+ L WKQRL + + ARG+ YLH + ++ IHRD+K +NILL Sbjct: 667 PQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLG 726 Query: 369 ENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLE 548 +++ AKVADFGL + PE + + T + G+FGYL PEY ++T K DVYSFGV+++E Sbjct: 727 DDMRAKVADFGLVRLAPE-GKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILME 785 Query: 549 VLCARPVIDPSLPREMVNLAEW 614 ++ R +D S P E ++L W Sbjct: 786 LITGRKSLDESQPEESIHLVSW 807
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 160 bits (404), Expect = 4e-39 Identities = 90/211 (42%), Positives = 126/211 (59%), Gaps = 4/211 (1%) Frame = +3 Query: 15 RXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEY 194 + L D TKVA+KR + + Q EF+ E+E +GYC+ +N+ +L+Y Y Sbjct: 759 KATLPDGTKVAIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSY 818 Query: 195 MENGTVKSHLYGSDN--PSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLD 368 M+NG++ L+ + PSL+WK RL I GAA GL YLH I+HRD+KS+NILL Sbjct: 819 MDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLS 878 Query: 369 ENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLE 548 + +A +ADFGL++ D THV+T + G+ GY+ PEY + T K DVYSFGVV+LE Sbjct: 879 DTFVAHLADFGLARLILPYD-THVTTDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLE 937 Query: 549 VLCARPVIDPSLPREMVNLAEW--GMKWQKR 635 +L R +D PR +L W MK +KR Sbjct: 938 LLTGRRPMDVCKPRGSRDLISWVLQMKTEKR 968
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 158 bits (400), Expect = 1e-38 Identities = 86/193 (44%), Positives = 118/193 (61%), Gaps = 2/193 (1%) Frame = +3 Query: 42 VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSH 221 +AVKR N + QG E+ EI IGYC E +LVYE+M G++++H Sbjct: 103 IAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENH 162 Query: 222 LY--GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 L+ G+ L+W R+ + +GAARGL +LH + +I+RD K++NILLD N AK++D Sbjct: 163 LFRRGTFYQPLSWNTRVRMALGAARGLAFLHNAQPQ-VIYRDFKASNILLDSNYNAKLSD 221 Query: 396 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 FGL++ GP D +HVST V G+ GY PEY L+ KSDVYSFGVV+LE+L R ID Sbjct: 222 FGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAID 281 Query: 576 PSLPREMVNLAEW 614 + P NL +W Sbjct: 282 KNQPVGEHNLVDW 294
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 152 bits (385), Expect = 6e-37 Identities = 87/209 (41%), Positives = 122/209 (58%), Gaps = 2/209 (0%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L D KVA+K+ + Q EF E+E G+C +N+ +L Sbjct: 746 GMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLL 805 Query: 183 VYEYMENGTVKSHLYG-SDNPSL-NWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 +Y YMENG++ L+ +D P+L WK RL I GAA+GL YLH G I+HRD+KS+N Sbjct: 806 IYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSN 865 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGV 536 ILLDEN + +ADFGL++ +THVST + G+ GY+ PEY + T K DVYSFGV Sbjct: 866 ILLDENFNSHLADFGLARLMSPY-ETHVSTDLVGTLGYIPPEYGQASVATYKGDVYSFGV 924 Query: 537 VMLEVLCARPVIDPSLPREMVNLAEWGMK 623 V+LE+L + +D P+ +L W +K Sbjct: 925 VLLELLTDKRPVDMCKPKGCRDLISWVVK 953
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 149 bits (375), Expect = 9e-36 Identities = 85/216 (39%), Positives = 121/216 (56%), Gaps = 3/216 (1%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L + VAVK+ + QG EF E+E +GYC E +L Sbjct: 929 GTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLL 988 Query: 183 VYEYMENGTVKSHLYGSDN--PSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 VYEYM NG++ L L+W +RL+I +GAARGL +LH G IIHRD+K++N Sbjct: 989 VYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASN 1048 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGV 536 ILLD + KVADFGL++ ++HVST + G+FGY+ PEY + + T K DVYSFGV Sbjct: 1049 ILLDGDFEPKVADFGLARL-ISACESHVSTVIAGTFGYIPPEYGQSARATTKGDVYSFGV 1107 Query: 537 VMLEVLCARPVIDPSLPR-EMVNLAEWGMKWQKRGE 641 ++LE++ + P E NL W ++ +G+ Sbjct: 1108 ILLELVTGKEPTGPDFKESEGGNLVGWAIQKINQGK 1143
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 148 bits (374), Expect = 1e-35 Identities = 88/219 (40%), Positives = 130/219 (59%), Gaps = 7/219 (3%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G+ + LRD + VA+K+ + QG EF E+E +GYC E +L Sbjct: 871 GEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLL 930 Query: 183 VYEYMENGTVKSHLYGSDNPS----LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKS 350 VYEYM+ G++++ L+ + LNW R +I IGAARGL +LH IIHRD+KS Sbjct: 931 VYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKS 990 Query: 351 ANILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYS 527 +N+LLDE+ A+V+DFG+++ LD TH+S + + G+ GY+ PEY++ + T K DVYS Sbjct: 991 SNVLLDEDFEARVSDFGMARLVSALD-THLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYS 1049 Query: 528 FGVVMLEVLCARPVIDPSLPREMVNLAEWGMKW--QKRG 638 +GV++LE+L + IDP E NL W + +KRG Sbjct: 1050 YGVILLELLSGKKPIDPGEFGEDNNLVGWAKQLYREKRG 1088
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 145 bits (367), Expect = 8e-35 Identities = 78/182 (42%), Positives = 116/182 (63%), Gaps = 2/182 (1%) Frame = +3 Query: 24 LRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMEN 203 L D ++AVKR + S QG +EF E+ +G C E +E +L+YEY+EN Sbjct: 547 LLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLEN 606 Query: 204 GTVKSHLYGSDNPS-LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLL 380 ++ S+L+G S LNW +R +I G ARGL YLH S IIHRD+K +NILLD+N++ Sbjct: 607 LSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMI 666 Query: 381 AKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLC 557 K++DFG+++ E D+T +T V G++GY+ PEY +EKSDV+SFGV++LE++ Sbjct: 667 PKISDFGMARIF-ERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVS 725 Query: 558 AR 563 + Sbjct: 726 GK 727
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 145 bits (365), Expect = 1e-34 Identities = 85/218 (38%), Positives = 128/218 (58%), Gaps = 6/218 (2%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L D + VA+K+ + QG EF E+E +GYC E +L Sbjct: 870 GDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETIGKIKHRNLVPLLGYCKIGEERLL 929 Query: 183 VYEYMENGTVKSHLYGSDNPS---LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 VYEYM+ G++++ L+ L+W R +I IGAARGL +LH IIHRD+KS+ Sbjct: 930 VYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSS 989 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSF 530 N+LLD++ +A+V+DFG+++ LD TH+S + + G+ GY+ PEY++ + T K DVYS+ Sbjct: 990 NVLLDQDFVARVSDFGMARLVSALD-THLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSY 1048 Query: 531 GVVMLEVLCARPVIDPSLPREMVNLAEWGMKW--QKRG 638 GV++LE+L + IDP E NL W + +KRG Sbjct: 1049 GVILLELLSGKKPIDPEEFGEDNNLVGWAKQLYREKRG 1086
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 144 bits (362), Expect = 3e-34 Identities = 83/194 (42%), Positives = 114/194 (58%), Gaps = 3/194 (1%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKR-GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMI 179 GK + L D T VAVKR ++Q G +F+TE+E G+C E + Sbjct: 301 GKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERL 360 Query: 180 LVYEYMENGTVKSHLYG--SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 LVY YM NG+V S L P L+W +R I +G+ARGL YLH IIHRDVK+A Sbjct: 361 LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAA 420 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 NILLDE A V DFGL+K + THV+TAV+G+ G++ PEY + +EK+DV+ +G Sbjct: 421 NILLDEEFEAVVGDFGLAKL-MDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYG 479 Query: 534 VVMLEVLCARPVID 575 V++LE++ + D Sbjct: 480 VMLLELITGQRAFD 493
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 140 bits (354), Expect = 3e-33 Identities = 80/194 (41%), Positives = 117/194 (60%), Gaps = 3/194 (1%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L+D + VA+K+ S QG EF E+E +GYC E +L Sbjct: 900 GDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLL 959 Query: 183 VYEYMENGTVKSHLYGSDNPS--LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 VYEYM+ G+++ L+ LNW R +I IGAARGL +LH IIHRD+KS+N Sbjct: 960 VYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSN 1019 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 +LLDENL A+V+DFG+++ +D TH+S + + G+ GY+ PEY++ + + K DVYS+G Sbjct: 1020 VLLDENLEARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYG 1078 Query: 534 VVMLEVLCARPVID 575 VV+LE+L + D Sbjct: 1079 VVLLELLTGKQPTD 1092
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 140 bits (354), Expect = 3e-33 Identities = 83/208 (39%), Positives = 123/208 (59%), Gaps = 4/208 (1%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L+D + VA+K+ S QG EF E+E +GYC +E +L Sbjct: 895 GDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLL 954 Query: 183 VYEYMENGTVKSHLYGSDNPS--LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 VYE+M+ G+++ L+ LNW R +I IG+ARGL +LH + IIHRD+KS+N Sbjct: 955 VYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSN 1014 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 +LLDENL A+V+DFG+++ +D TH+S + + G+ GY+ PEY++ + + K DVYS+G Sbjct: 1015 VLLDENLEARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYG 1073 Query: 534 VVMLEVLCA-RPVIDPSLPREMVNLAEW 614 VV+LE+L RP P NL W Sbjct: 1074 VVLLELLTGKRPTDSPDFGDN--NLVGW 1099
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 140 bits (352), Expect = 4e-33 Identities = 80/194 (41%), Positives = 117/194 (60%), Gaps = 3/194 (1%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L+D + VA+K+ S QG EF E+E +GYC E +L Sbjct: 900 GDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLL 959 Query: 183 VYEYMENGTVKSHLYGSDNPS--LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 VYEYM+ G+++ L+ LNW R +I IGAARGL +LH IIHRD+KS+N Sbjct: 960 VYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSN 1019 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 +LLDENL A+V+DFG+++ +D TH+S + + G+ GY+ PEY++ + + K DVYS+G Sbjct: 1020 VLLDENLEARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYG 1078 Query: 534 VVMLEVLCARPVID 575 VV+LE+L + D Sbjct: 1079 VVLLELLTGKQPTD 1092
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 136 bits (343), Expect = 5e-32 Identities = 81/218 (37%), Positives = 125/218 (57%), Gaps = 5/218 (2%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G+ + L+D + VA+K+ S QG EF E+E +GYC E +L Sbjct: 850 GEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLL 909 Query: 183 VYEYMENGTVKSHLYGSDNPS----LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKS 350 VYE+M+ G+++ L+G L W++R +I GAA+GL +LH IIHRD+KS Sbjct: 910 VYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKS 969 Query: 351 ANILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYS 527 +N+LLD+++ A+V+DFG+++ LD TH+S + + G+ GY+ PEY++ + T K DVYS Sbjct: 970 SNVLLDQDMEARVSDFGMARLISALD-THLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYS 1028 Query: 528 FGVVMLEVLCARPVIDPSLPREMVNLAEWGMKWQKRGE 641 GVVMLE+L + D + NL W + G+ Sbjct: 1029 IGVVMLEILSGKRPTDKEEFGD-TNLVGWSKMKAREGK 1065
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 132 bits (331), Expect = 1e-30 Identities = 76/204 (37%), Positives = 115/204 (56%), Gaps = 4/204 (1%) Frame = +3 Query: 15 RXALRDDTKVAVKR----GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 R ++ ++ VA+KR G +S G F EI+ +GY ++ +L Sbjct: 708 RGSMPNNVDVAIKRLVGRGTGRSDHG---FTAEIQTLGRIRHRHIVRLLGYVANKDTNLL 764 Query: 183 VYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANIL 362 +YEYM NG++ L+GS L W+ R + + AA+GL YLH + I+HRDVKS NIL Sbjct: 765 LYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNIL 824 Query: 363 LDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVM 542 LD + A VADFGL+K + + +++ GS+GY+ PEY ++ EKSDVYSFGVV+ Sbjct: 825 LDSDFEAHVADFGLAKFLVDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVL 884 Query: 543 LEVLCARPVIDPSLPREMVNLAEW 614 LE++ + + E V++ W Sbjct: 885 LELIAGKKPVGEF--GEGVDIVRW 906
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 127 bits (319), Expect = 3e-29 Identities = 81/218 (37%), Positives = 112/218 (51%), Gaps = 14/218 (6%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNE----------FRTEIEXXXXXXXXXXXXXIG 152 GK + LR VAVK+ N + G +E F E+E Sbjct: 695 GKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHKSIVRLWC 754 Query: 153 YCDERNEMILVYEYMENGTVKSHLYGSDNPS--LNWKQRLEICIGAARGLHYLHTGSAKA 326 C + +LVYEYM NG++ L+G L W +RL I + AA GL YLH Sbjct: 755 CCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPP 814 Query: 327 IIHRDVKSANILLDENLLAKVADFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYFRRQQ 500 I+HRDVKS+NILLD + AKVADFG++K G + + GS GY+ PEY + Sbjct: 815 IVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYVYTLR 874 Query: 501 LTEKSDVYSFGVVMLEVLCARPVIDPSLPREMVNLAEW 614 + EKSD+YSFGVV+LE++ + D L + ++A+W Sbjct: 875 VNEKSDIYSFGVVLLELVTGKQPTDSELGDK--DMAKW 910
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 121 bits (303), Expect = 2e-27 Identities = 69/187 (36%), Positives = 110/187 (58%), Gaps = 5/187 (2%) Frame = +3 Query: 30 DDTKVAVKR----GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYM 197 ++T VAVK+ + +++ +F EI+ +G+ + +++ LVY YM Sbjct: 206 NNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYM 265 Query: 198 ENGTVKSHLYGSDN-PSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDEN 374 NG++ L D P L+W R +I GAA G+++LH IHRD+KSANILLDE Sbjct: 266 PNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEA 322 Query: 375 LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 AK++DFGL++ + QT +++ + G+ Y+ PE R ++T KSD+YSFGVV+LE++ Sbjct: 323 FTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL-RGEITPKSDIYSFGVVLLEII 381 Query: 555 CARPVID 575 P +D Sbjct: 382 TGLPAVD 388
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 118 bits (295), Expect = 2e-26 Identities = 70/185 (37%), Positives = 100/185 (54%), Gaps = 1/185 (0%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + L DD VAVK+ +QG F+ E+ G+C E + +L Sbjct: 546 GTVYKGVLEDDRHVAVKKLE-NVRQGKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLL 604 Query: 183 VYEYMENGTVKSHLYGSD-NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 V EY+ENG++ + L+ N L+W+ R I +G A+GL YLH + +IH DVK NI Sbjct: 605 VSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENI 664 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 LLD+ K+ DFGL K T + V+G+ GY+ PE+ +T K DVYS+GVV Sbjct: 665 LLDQAFEPKITDFGLVKLLNRGGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGVV 724 Query: 540 MLEVL 554 +LE+L Sbjct: 725 LLELL 729
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 115 bits (289), Expect = 9e-26 Identities = 68/200 (34%), Positives = 114/200 (57%), Gaps = 6/200 (3%) Frame = +3 Query: 30 DDTKVAVKRGNP----KSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYM 197 ++T VAVK+ +++ +F EI+ +G+ + + + LVY YM Sbjct: 206 NNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYM 265 Query: 198 ENGTVKSHLYGSDN-PSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDEN 374 NG++ L D P L+W R ++ G A G+ +LH IHRD+KSANILLD++ Sbjct: 266 PNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKD 322 Query: 375 LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 AK++DFGL++ L QT +++ + G+ Y+ PE R ++T KSD+YSFGVV+LE++ Sbjct: 323 FTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEAL-RGEITPKSDIYSFGVVLLELI 381 Query: 555 CARPVIDPSL-PREMVNLAE 611 +D + P+ ++++ E Sbjct: 382 TGLAAVDENREPQLLLDIKE 401
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 113 bits (282), Expect = 6e-25 Identities = 63/147 (42%), Positives = 91/147 (61%), Gaps = 5/147 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHL--YGSDNP--SLNWKQRLEICIGAARGLHYLHTGS 317 GY + + LVY+ M+ G++++ L + + NP +L W+QR I +G ARG+++LHT Sbjct: 279 GYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTAR 338 Query: 318 AKAIIHRDVKSANILLDENLLAKVADFGLSKTGPE-LDQTHVSTAVKGSFGYLDPEYFRR 494 +IH D+K ANILLD+ L K+ DFGL + GP+ LD V G+ YL PE+ Sbjct: 339 GTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNF 398 Query: 495 QQLTEKSDVYSFGVVMLEVLCARPVID 575 +QL+ DVYSFG+V+LEV R V D Sbjct: 399 RQLSTGVDVYSFGIVLLEVFTGRQVTD 425
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 112 bits (281), Expect = 7e-25 Identities = 60/160 (37%), Positives = 95/160 (59%), Gaps = 2/160 (1%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYGSDNPS-LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++Y YMENG++ L+ ++ P L+W R I +G A GL YLH AI+HRD+K Sbjct: 887 LILYTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPM 946 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 NILLD +L ++DFG++K + + S V+G+ GY+ PE + +SDVYS+G Sbjct: 947 NILLDSDLEPHISDFGIAKLLDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYG 1006 Query: 534 VVMLEVLCARPVIDPSLPREMVNLAEWGMK-WQKRGELHQ 650 VV+LE++ + +DPS E ++ W W + GE+ + Sbjct: 1007 VVLLELITRKKALDPSFNGE-TDIVGWVRSVWTQTGEIQK 1045
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 108 bits (270), Expect = 1e-23 Identities = 67/197 (34%), Positives = 104/197 (52%), Gaps = 13/197 (6%) Frame = +3 Query: 21 ALRDDTKVAVKRGNPKSQ----QGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVY 188 A+ +T AVKR ++ F TE+E GYC E LVY Sbjct: 229 AVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVY 288 Query: 189 EYMENGTVKS--HLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANIL 362 ++ NG+++ HL L+W QRL+I +G AR + +LH S ++IH D+KS+N+L Sbjct: 289 GFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVL 347 Query: 363 LDENLLAKVADFGLSK----TGPELDQTHV---STAVKGSFGYLDPEYFRRQQLTEKSDV 521 LDE L+ K+ DFGL++ G + Q+ ++ V+G+ YL EY + +L +D Sbjct: 348 LDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDT 407 Query: 522 YSFGVVMLEVLCARPVI 572 +SFGVV+LE L + + Sbjct: 408 FSFGVVILETLAGQRAV 424
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 107 bits (266), Expect = 4e-23 Identities = 60/170 (35%), Positives = 93/170 (54%), Gaps = 9/170 (5%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDN--PSLNWKQR 263 F TE+E GYC + LVY ++ NG+++ L+ P L+W QR Sbjct: 256 FLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQR 315 Query: 264 LEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSK----TGPELDQ 431 L+I +G AR + +LH S ++IH D+KS+N+LLDE L K+ DFGL++ G Q Sbjct: 316 LDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQ 374 Query: 432 THV---STAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVI 572 + + + V+G+ YL EY + +L +D +SFGVV+LE L + + Sbjct: 375 SSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAV 424
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 102 bits (255), Expect = 8e-22 Identities = 52/139 (37%), Positives = 86/139 (61%), Gaps = 2/139 (1%) Frame = +3 Query: 153 YCDERNEMILVYEYMENGTVKSHLYGSD--NPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 Y +R E +L+Y+Y+ N ++ L+ S P+LNW +R +I +G ARGL YLHTG Sbjct: 436 YQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVP 495 Query: 327 IIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 IIH +++S N+L+D+ A++ +FGL K + + + K S GY PE + ++ Sbjct: 496 IIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAK-SDGYKAPELHKMKKCN 554 Query: 507 EKSDVYSFGVVMLEVLCAR 563 +SDVY+FG+++LE+L + Sbjct: 555 PRSDVYAFGILLLEILMGK 573
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 99.4 bits (246), Expect = 8e-21 Identities = 58/166 (34%), Positives = 88/166 (53%), Gaps = 5/166 (3%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPS-LNWKQRL 266 F +E+E Y E ++ LVY YM NGT+ L ++ + L+W R+ Sbjct: 222 FLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRI 281 Query: 267 EICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVST 446 + IG A+ + YLH A+I +V SANILLD+ L K+ DF + P L+Q + Sbjct: 282 SVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTI 341 Query: 447 AVKGS----FGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVI 572 + G Y+ EY R+ +L+ K+DVYSFG+V++EVL V+ Sbjct: 342 NMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVV 387
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 99.4 bits (246), Expect = 8e-21 Identities = 72/222 (32%), Positives = 107/222 (48%), Gaps = 24/222 (10%) Frame = +3 Query: 42 VAVKR--GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVK 215 VAVK+ S+ L EFR E+ IG C ++ + +V EYM G ++ Sbjct: 1388 VAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLR 1447 Query: 216 SHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 L D + + +L++ GAA G+ YLH+ S I+HRD+K ANIL+DE+ K+AD Sbjct: 1448 DVLKNPDI-KITFANKLKLLYGAAMGIDYLHS-SNPMIVHRDIKPANILVDEHFNVKIAD 1505 Query: 396 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLC------ 557 FG ++ + + + + G+ + PE R ++ EK+DV+SFGVVM EVL Sbjct: 1506 FGFAR----IKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKEPFA 1561 Query: 558 --------------ARPVIDPSLPREMVNLAE--WGMKWQKR 635 RP+I P E L + W K KR Sbjct: 1562 ECNFMKVSLDILEGGRPIIPSDCPHEFAKLIKKCWHAKAHKR 1603 Score = 81.6 bits (200), Expect = 2e-15 Identities = 52/177 (29%), Positives = 91/177 (51%), Gaps = 4/177 (2%) Frame = +3 Query: 36 TKVAVKRGNPK--SQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGT 209 T+VAVK + K S+ F E++ + + M +V E+M G+ Sbjct: 808 TEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGS 867 Query: 210 VKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 + L P + + ++++ A++G+H+LH+ I+HRD+KS N+LLD KV Sbjct: 868 LYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKV 924 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE--KSDVYSFGVVMLEVL 554 +DFGL+K ELD+ + + G+ ++ PE + +DVYSFG+++ E+L Sbjct: 925 SDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVYSFGIILWELL 981
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 90.5 bits (223), Expect = 4e-18 Identities = 55/168 (32%), Positives = 86/168 (51%), Gaps = 6/168 (3%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYG-SDNPSLNWKQRL 266 F +E+E Y E + L+Y YM NGT+ L D L W R+ Sbjct: 209 FLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRI 268 Query: 267 EICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQ----T 434 I IG ++ +HYLH ++I + SANILLD+ K+ DF ++ L+ Sbjct: 269 GILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTI 328 Query: 435 HVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLC-ARPVID 575 +++++ Y+ EY R+ +L+ K+DVYSFG+V++EVL R V+D Sbjct: 329 NMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLD 376
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/147 (36%), Positives = 78/147 (53%), Gaps = 4/147 (2%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPS-LNWKQRLEICIGAARGLHYLHTGSAK 323 +G+C R +Y YM NG+++ L G L W QR+ IC G + YLH Sbjct: 273 LGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLH---GL 329 Query: 324 AIIHRDVKSANILLDENLLAKVAD--FGLSKTGPELDQTHVST-AVKGSFGYLDPEYFRR 494 IIH +VKS+N+LLD+NL K+A L T + T ++ S YL ++ R Sbjct: 330 EIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRV 389 Query: 495 QQLTEKSDVYSFGVVMLEVLCARPVID 575 QLT++ D++S G+V+ EVL P +D Sbjct: 390 GQLTKRVDIFSCGIVLAEVLTGIPAMD 416
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 86.7 bits (213), Expect = 6e-17 Identities = 67/213 (31%), Positives = 102/213 (47%), Gaps = 19/213 (8%) Frame = +3 Query: 33 DTKVAVK---RGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNE--MILVYEYM 197 +T VA+K R K++ L F+ E+ +G C E +V E+M Sbjct: 1310 ETDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWM 1369 Query: 198 ENGTVKSHLYGSDNP-SLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDEN 374 G+++ L N N RL++ + A+G++YLH G I+HRD+ S NILLD N Sbjct: 1370 GGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLH-GWTPPILHRDLSSRNILLDHN 1428 Query: 375 L-------------LAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKS 515 + K++DFGLS+ E Q T G Y+ PE F+ +EKS Sbjct: 1429 IDPKNPVVSSRQDIKCKISDFGLSRLKKE--QASQMTQSVGCIPYMAPEVFKGDSNSEKS 1486 Query: 516 DVYSFGVVMLEVLCARPVIDPSLPREMVNLAEW 614 DVYS+G+V+ E+L + P +M +LA + Sbjct: 1487 DVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAY 1519
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 85.1 bits (209), Expect = 2e-16 Identities = 55/153 (35%), Positives = 82/153 (53%), Gaps = 5/153 (3%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G C + ++ + EYM GT++ L S P L+W RL + + ARGL YLH+ K Sbjct: 116 MGVCVHQGQLHALTEYMNGGTLEQ-LLSSPEP-LSWPVRLHLALDIARGLRYLHS---KG 170 Query: 327 IIHRDVKSANILL---DENLLAKVADFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYFR 491 + HRD+ S N L+ D A V DFGL++ P + AV GS ++ PE R Sbjct: 171 VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLR 230 Query: 492 RQQLTEKSDVYSFGVVMLEVLCARPVIDPSLPR 590 + EK+DV++FG+V+ E++ P LPR Sbjct: 231 GELYDEKADVFAFGIVLCELIARVPADPDYLPR 263
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 84.7 bits (208), Expect = 2e-16 Identities = 55/153 (35%), Positives = 82/153 (53%), Gaps = 5/153 (3%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G C + ++ + EYM GT++ L S P L+W RL + + A+GL YLH AK Sbjct: 111 MGVCVHQGQLHALTEYMNGGTLEQ-LLSSPEP-LSWPVRLHLALDIAQGLRYLH---AKG 165 Query: 327 IIHRDVKSANILL---DENLLAKVADFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYFR 491 + HRD+ S N L+ D A V DFGL++ P + AV GS ++ PE R Sbjct: 166 VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLR 225 Query: 492 RQQLTEKSDVYSFGVVMLEVLCARPVIDPSLPR 590 + EK+DV++FG+V+ E++ P LPR Sbjct: 226 GELYDEKADVFAFGIVLCELIARVPADPDYLPR 258
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 84.3 bits (207), Expect = 3e-16 Identities = 48/158 (30%), Positives = 83/158 (52%) Frame = +3 Query: 87 EFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRL 266 +F++E+ I C + ++ EYM G ++ +L + SL+ + L Sbjct: 131 QFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVL 190 Query: 267 EICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVST 446 + + +RG+ YLH+ + +IHRD+KS N+LL++ + KVADFG S Q + Sbjct: 191 RLALDISRGMEYLHS---QGVIHRDLKSNNLLLNDEMRVKVADFGTSCLE---TQCREAK 244 Query: 447 AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCA 560 G++ ++ PE + + T K DVYSFG+V+ E+ A Sbjct: 245 GNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTA 282
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 84.3 bits (207), Expect = 3e-16 Identities = 50/154 (32%), Positives = 86/154 (55%), Gaps = 3/154 (1%) Frame = +3 Query: 147 IGYCDERNEM--ILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSA 320 +G C E +M +++ EYM+NG++K +L D N Q + + + G+ YL + Sbjct: 279 LGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLES--- 335 Query: 321 KAIIHRDVKSANILLDENLLAKVADFGLSK-TGPELDQTHVSTAVKGSFGYLDPEYFRRQ 497 + ++HRD+++ NIL+ +L KVADFGL++ T L T ++ + + PE + + Sbjct: 336 EKVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKT-LRFPYKWTAPEAAKSK 394 Query: 498 QLTEKSDVYSFGVVMLEVLCARPVIDPSLPREMV 599 T KSDV+S+G+VM E+L P +P + V Sbjct: 395 VFTSKSDVWSYGIVMFEILTWASSPYPDIPAKEV 428
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 84.0 bits (206), Expect = 4e-16 Identities = 55/153 (35%), Positives = 82/153 (53%), Gaps = 5/153 (3%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G C + ++ + EYM GT++ L S P L+W RL + + A+GL YLH AK Sbjct: 111 MGVCVHQGQLHALTEYMNGGTLEQ-LLSSPEP-LSWPVRLHLALDIAQGLRYLH---AKG 165 Query: 327 IIHRDVKSANILL---DENLLAKVADFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYFR 491 + HRD+ S N L+ D A V DFGL++ P + AV GS ++ PE R Sbjct: 166 VFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLR 225 Query: 492 RQQLTEKSDVYSFGVVMLEVLCARPVIDPSLPR 590 + EK+DV++FG+V+ E++ P LPR Sbjct: 226 GELYDEKADVFAFGIVLCELIARVPADPDYLPR 258
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 83.2 bits (204), Expect = 6e-16 Identities = 57/182 (31%), Positives = 90/182 (49%), Gaps = 10/182 (5%) Frame = +3 Query: 39 KVAVKR---GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGT 209 +VAVK P N+ E E +G C+E + +V EYM NG+ Sbjct: 43 RVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS 102 Query: 210 VKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAK 386 + L+ ++ P + W R I A G++YLH + ++H D+K+ NILLD K Sbjct: 103 LNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNPP-LLHHDLKTQNILLDNEFHVK 161 Query: 387 VADFGLSK---TGPELDQTHVSTAVKGSFGYLDPEYF---RRQQLTEKSDVYSFGVVMLE 548 +ADFGLSK +++ S G+ Y+ PE + ++ + + K D+YS+ V+M E Sbjct: 162 IADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWE 221 Query: 549 VL 554 VL Sbjct: 222 VL 223
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 83.2 bits (204), Expect = 6e-16 Identities = 56/152 (36%), Positives = 85/152 (55%), Gaps = 4/152 (2%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G C + ++ + EY+ +G ++ L N L W R+++ A GL YLH K Sbjct: 117 MGVCVHQGQLHALTEYINSGNLEQLL--DSNLHLPWTVRVKLAYDIAVGLSYLHF---KG 171 Query: 327 IIHRDVKSANILL--DEN-LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQ 497 I HRD+ S N L+ DEN A VADFGL++ P++ AV GS ++ PE R + Sbjct: 172 IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDE 231 Query: 498 QLTEKSDVYSFGVVMLEVLCARPVIDPS-LPR 590 EK+DV+S+G+++ E++ AR DP LPR Sbjct: 232 PYNEKADVFSYGIILCEII-ARIQADPDYLPR 262
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 83.2 bits (204), Expect = 6e-16 Identities = 52/158 (32%), Positives = 84/158 (53%), Gaps = 1/158 (0%) Frame = +3 Query: 81 LNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSD-NPSLNWK 257 +NEF E+ +G + + +V EY+ G++ L+ S L+ + Sbjct: 590 VNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDER 649 Query: 258 QRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTH 437 +RL + A+G++YLH + I+HRD+KS N+L+D+ KV DFGLS+ + Sbjct: 650 RRLSMAYDVAKGMNYLHNRNPP-IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSS 708 Query: 438 VSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 S A G+ ++ PE R + EKSDVYSFGV++ E+ Sbjct: 709 KSAA--GTPEWMAPEVLRDEPSNEKSDVYSFGVILWEL 744
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 11/186 (5%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK S +F E E G C E + +I+V+EYM++G Sbjct: 563 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 622 Query: 207 TVKSHL--YGSD-------NP--SLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + L +G D NP L Q L I A G+ YL +++ +HRD+ + Sbjct: 623 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 679 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 N L+ ENLL K+ DFG+S+ D V ++ PE ++ T +SDV+S G Sbjct: 680 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG 739 Query: 534 VVMLEV 551 VV+ E+ Sbjct: 740 VVLWEI 745
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 11/186 (5%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK S +F E E G C E + +I+V+EYM++G Sbjct: 563 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 622 Query: 207 TVKSHL--YGSD-------NP--SLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + L +G D NP L Q L I A G+ YL +++ +HRD+ + Sbjct: 623 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 679 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 N L+ ENLL K+ DFG+S+ D V ++ PE ++ T +SDV+S G Sbjct: 680 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG 739 Query: 534 VVMLEV 551 VV+ E+ Sbjct: 740 VVLWEI 745
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 11/186 (5%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK S +F E E G C E + +I+V+EYM++G Sbjct: 564 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 623 Query: 207 TVKSHL--YGSD-------NP--SLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + L +G D NP L Q L I A G+ YL +++ +HRD+ + Sbjct: 624 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 680 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 N L+ ENLL K+ DFG+S+ D V ++ PE ++ T +SDV+S G Sbjct: 681 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG 740 Query: 534 VVMLEV 551 VV+ E+ Sbjct: 741 VVLWEI 746
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 81.6 bits (200), Expect = 2e-15 Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 1/185 (0%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G + R A + ++AVK + + EI IG + L Sbjct: 22 GGAVRKATFQNQEIAVKIFDFLEETIKKNAEREITHLSEIDHENVIRVIGRASNGKKDYL 81 Query: 183 VYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANIL 362 + EY+E G++ ++LYG D +Q + + A+ L YLH+ + I+HRD+K N+L Sbjct: 82 LMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLD-RPIVHRDIKPQNML 140 Query: 363 L-DENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L +++ K+ DFGL+ D ++ T ++G+ Y+ PE + + T K DVYSFG++ Sbjct: 141 LYNQHEDLKICDFGLAT-----DMSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVYSFGIM 195 Query: 540 MLEVL 554 + E++ Sbjct: 196 LWELM 200
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 81.3 bits (199), Expect = 2e-15 Identities = 50/138 (36%), Positives = 80/138 (57%), Gaps = 2/138 (1%) Frame = +3 Query: 168 NEMILVYEYMENGTVKSHLYGSDN-PSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 N + LV EY E G++ + L+G++ P + C+ ++G+ YLH+ KA+IHRD+ Sbjct: 98 NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDL 157 Query: 345 KSANILLDEN-LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDV 521 K N+LL + K+ DFG T ++ QTH+ T KGS ++ PE F +EK DV Sbjct: 158 KPPNLLLVAGGTVLKICDFG---TACDI-QTHM-TNNKGSAAWMAPEVFEGSNYSEKCDV 212 Query: 522 YSFGVVMLEVLCARPVID 575 +S+G+++ EV+ R D Sbjct: 213 FSWGIILWEVITRRKPFD 230
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 81.3 bits (199), Expect = 2e-15 Identities = 50/138 (36%), Positives = 80/138 (57%), Gaps = 2/138 (1%) Frame = +3 Query: 168 NEMILVYEYMENGTVKSHLYGSDN-PSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 N + LV EY E G++ + L+G++ P + C+ ++G+ YLH+ KA+IHRD+ Sbjct: 98 NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDL 157 Query: 345 KSANILLDEN-LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDV 521 K N+LL + K+ DFG T ++ QTH+ T KGS ++ PE F +EK DV Sbjct: 158 KPPNLLLVAGGTVLKICDFG---TACDI-QTHM-TNNKGSAAWMAPEVFEGSNYSEKCDV 212 Query: 522 YSFGVVMLEVLCARPVID 575 +S+G+++ EV+ R D Sbjct: 213 FSWGIILWEVITRRKPFD 230
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 80.9 bits (198), Expect = 3e-15 Identities = 56/152 (36%), Positives = 84/152 (55%), Gaps = 4/152 (2%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G C + ++ + EY+ +G ++ L N L W R+++ A GL YLH K Sbjct: 117 MGVCVHQGQLHALTEYINSGNLEQLL--DSNLYLPWTVRVKLAYDIAVGLSYLHF---KG 171 Query: 327 IIHRDVKSANILL--DEN-LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQ 497 I HRD+ S N L+ DEN A VADFGL++ P+ AV GS ++ PE R + Sbjct: 172 IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGSEKLAVVGSPFWMAPEVLRDE 231 Query: 498 QLTEKSDVYSFGVVMLEVLCARPVIDPS-LPR 590 EK+DV+S+G+++ E++ AR DP LPR Sbjct: 232 PYNEKADVFSYGIILCEII-ARIQADPDYLPR 262
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 80.5 bits (197), Expect = 4e-15 Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + L FR E+ +GY + N + +V ++ E ++ Sbjct: 362 DVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 420 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ D Q ++I A+G+ YLH AK IIHRD+KS NI L E L K+ Sbjct: 421 YYHLHVLDT-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIG 476 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 477 DFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 533
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 80.5 bits (197), Expect = 4e-15 Identities = 55/186 (29%), Positives = 84/186 (45%), Gaps = 11/186 (5%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK S +F E E G C E + +I+V+EYM++G Sbjct: 560 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 619 Query: 207 TVKSHLY-----------GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + L G+ L Q L I A G+ YL +++ +HRD+ + Sbjct: 620 DLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 676 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 N L+ ENLL K+ DFG+S+ D V ++ PE ++ T +SDV+S G Sbjct: 677 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG 736 Query: 534 VVMLEV 551 VV+ E+ Sbjct: 737 VVLWEI 742
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 6/177 (3%) Frame = +3 Query: 42 VAVKRGN---PKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 VAVK N P QQ L F+ E+ +GY + ++ +V ++ E ++ Sbjct: 90 VAVKMLNVTAPTPQQ-LQAFKNEVGVLRKTRHVNILLFMGY-STKPQLAIVTQWCEGSSL 147 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 148 YHHLHIIET-KFEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIG 203 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ +H + GS ++ PE R Q + +SDVY+FG+V+ E++ Sbjct: 204 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 260
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 6/177 (3%) Frame = +3 Query: 42 VAVKRGN---PKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 VAVK N P QQ L F+ E+ +GY + ++ +V ++ E ++ Sbjct: 520 VAVKMLNVTAPTPQQ-LQAFKNEVGVLRKTRHVNILLFMGY-STKPQLAIVTQWCEGSSL 577 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 578 YHHLHIIET-KFEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIG 633 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ +H + GS ++ PE R Q + +SDVY+FG+V+ E++ Sbjct: 634 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 690
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 6/177 (3%) Frame = +3 Query: 42 VAVKRGN---PKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 VAVK N P QQ L F+ E+ +GY + ++ +V ++ E ++ Sbjct: 106 VAVKMLNVTAPTPQQ-LQAFKNEVGVLRKTRHVNILLFMGY-STKPQLAIVTQWCEGSSL 163 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 164 YHHLHIIET-KFEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIG 219 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ +H + GS ++ PE R Q + +SDVY+FG+V+ E++ Sbjct: 220 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 276
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 80.1 bits (196), Expect = 5e-15 Identities = 61/178 (34%), Positives = 89/178 (50%), Gaps = 7/178 (3%) Frame = +3 Query: 42 VAVKRGNPK--SQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVK 215 VAVK N K S L F+ E+ +G C + + +V ++ E ++ Sbjct: 452 VAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLY 510 Query: 216 SHLYGSDNPSLNWKQRLEICIG--AARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 H++ S+ +K I IG A+G+ YLH AK IIHRD+KS NI L E+L K+ Sbjct: 511 KHVHVSET---KFKLNTLIDIGRQVAQGMDYLH---AKNIIHRDLKSNNIFLHEDLSVKI 564 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE---KSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q+L +SDVY+FG+VM E+L Sbjct: 565 GDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELL 622
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 6/177 (3%) Frame = +3 Query: 42 VAVKRGN---PKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 VAVK N P QQ L F+ E+ +GY + ++ +V ++ E ++ Sbjct: 480 VAVKMLNVTAPTPQQ-LQAFKNEVGVLRKTRHVNILLFMGY-STKPQLAIVTQWCEGSSL 537 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 538 YHHLHIIET-KFEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIG 593 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ +H + GS ++ PE R Q + +SDVY+FG+V+ E++ Sbjct: 594 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 650
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 6/177 (3%) Frame = +3 Query: 42 VAVKRGN---PKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 VAVK N P QQ L F+ E+ +GY + ++ +V ++ E ++ Sbjct: 42 VAVKMLNVTAPTPQQ-LQAFKNEVGVLRKTRHVNILLFMGY-STKPQLAIVTQWCEGSSL 99 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 100 YHHLHIIET-KFEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIG 155 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ +H + GS ++ PE R Q + +SDVY+FG+V+ E++ Sbjct: 156 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 212
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 6/177 (3%) Frame = +3 Query: 42 VAVKRGN---PKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 VAVK N P QQ L F+ E+ +GY + ++ +V ++ E ++ Sbjct: 520 VAVKMLNVTAPTPQQ-LQAFKNEVGVLRKTRHVNILLFMGY-STKPQLAIVTQWCEGSSL 577 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 578 YHHLHIIET-KFEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIG 633 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ +H + GS ++ PE R Q + +SDVY+FG+V+ E++ Sbjct: 634 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 690
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 79.3 bits (194), Expect = 9e-15 Identities = 55/152 (36%), Positives = 84/152 (55%), Gaps = 4/152 (2%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G C + ++ + EY+ +G ++ L + L W R+++ A GL YLH K Sbjct: 117 MGVCVHQGQLHALTEYINSGNLEQLL--DSDLYLPWTVRVKLAYDIAVGLSYLHF---KG 171 Query: 327 IIHRDVKSANILL--DEN-LLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQ 497 I HRD+ S N L+ DEN A VADFGL++ P+ AV GS ++ PE R + Sbjct: 172 IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGREKLAVVGSPFWMAPEVLRDE 231 Query: 498 QLTEKSDVYSFGVVMLEVLCARPVIDPS-LPR 590 EK+DV+S+G+++ E++ AR DP LPR Sbjct: 232 PYNEKADVFSYGIILCEII-ARIQADPDYLPR 262
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 79.3 bits (194), Expect = 9e-15 Identities = 48/139 (34%), Positives = 76/139 (54%), Gaps = 1/139 (0%) Frame = +3 Query: 153 YCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAII 332 Y D + +V EY++ T++ L+ L ++ LE+ IG + L Y H I+ Sbjct: 81 YIDNVSIPYIVMEYVDGSTLRELLHSGRK--LLPERTLEMTIGILQALEYSHRAG---IV 135 Query: 333 HRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVST-AVKGSFGYLDPEYFRRQQLTE 509 HRD+K AN++L N KV DFG+++ + T T AV G+ YL PE + +Q+ Sbjct: 136 HRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQTAAVIGTAQYLSPEQAKGEQVDA 195 Query: 510 KSDVYSFGVVMLEVLCARP 566 +SD+YS G ++ E+L RP Sbjct: 196 RSDLYSTGCLLYELLTVRP 214
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 79.3 bits (194), Expect = 9e-15 Identities = 53/159 (33%), Positives = 87/159 (54%), Gaps = 8/159 (5%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAK 323 +G C+E + +V EYM NG++ L+ ++ P + W R I A G++YLH Sbjct: 82 LGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN-MTP 140 Query: 324 AIIHRDVKSANILLDENLLAKVADFGLSK-TGPELDQTHVSTAVK--GSFGYLDPEYF-- 488 ++H D+K+ NILLD K+ADFGLSK L Q+ S + G+ Y+ PE + Sbjct: 141 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 200 Query: 489 -RRQQLTEKSDVYSFGVVMLEVLCAR-PVIDPSLPREMV 599 ++ + + K D+YS+ V+ EVL + P D + P +++ Sbjct: 201 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIM 239
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 77.8 bits (190), Expect = 3e-14 Identities = 46/133 (34%), Positives = 74/133 (55%) Frame = +3 Query: 168 NEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 NE+ ++ EYM+ G++ + +D LN KQ IC +GL +LH K IIHRD+K Sbjct: 750 NELWVIMEYMQGGSLTEIIENNDF-KLNEKQIATICFETLKGLQHLHK---KHIIHRDIK 805 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 S N+LLD K+ DFG DQ + + G+ ++ PE ++++ EK DV+S Sbjct: 806 SDNVLLDAYGNVKITDFGF--CAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVWS 863 Query: 528 FGVVMLEVLCARP 566 G++ +E++ P Sbjct: 864 LGIMTIEMIEGEP 876
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 77.8 bits (190), Expect = 3e-14 Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + L FR E+ +GY + N + +V ++ E ++ Sbjct: 371 DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 429 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + Q ++I A+G+ YLH AK IIHRD+KS NI L E L K+ Sbjct: 430 YKHLHVQET-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIG 485 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 486 DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 542
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 77.8 bits (190), Expect = 3e-14 Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + L FR E+ +GY + N + +V ++ E ++ Sbjct: 371 DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 429 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + Q ++I A+G+ YLH AK IIHRD+KS NI L E L K+ Sbjct: 430 YKHLHVQET-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIG 485 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 486 DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELM 542
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 77.8 bits (190), Expect = 3e-14 Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + L FR E+ +GY + N + +V ++ E ++ Sbjct: 46 DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 104 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + Q ++I A+G+ YLH AK IIHRD+KS NI L E L K+ Sbjct: 105 YKHLHVQET-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIG 160 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 161 DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELM 217
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 77.4 bits (189), Expect = 3e-14 Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 1/175 (0%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D VAVK ++Q + E++ G + L+ E+ E G++ Sbjct: 40 DKLVAVKEFFASAEQ--KDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSL 97 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILL-DENLLAKV 389 + L+G P+ + + A GL YLH + K +IHRDVK N+LL ++ K+ Sbjct: 98 HNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKI 157 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 DF G D++ + T +GS ++ PE F + TEK D++S+ +V+ EVL Sbjct: 158 CDF-----GTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVL 207
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 77.4 bits (189), Expect = 3e-14 Identities = 48/134 (35%), Positives = 74/134 (55%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C E+ + LV+E+ME+G + +L S + L +C+ G+ YL + Sbjct: 428 GVCLEQAPICLVFEFMEHGCLSDYLR-SQRGLFAAETLLGMCLDVCEGMAYLEKA---CV 483 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 IHRD+ + N L+ EN + KV+DFG+++ + DQ ST K + PE F + + Sbjct: 484 IHRDLAARNCLVGENQVIKVSDFGMTRFVLD-DQYTSSTGTKFPVKWASPEVFSFSRYSS 542 Query: 510 KSDVYSFGVVMLEV 551 KSDV+SFGV+M EV Sbjct: 543 KSDVWSFGVLMWEV 556
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/189 (28%), Positives = 86/189 (45%), Gaps = 14/189 (7%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK + +F+ E E G C + + +I+V+EYM++G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 207 TVKSHL--YGSD------------NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 + L +G D L Q L I A G+ YL +++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 345 KSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVY 524 + N L+ NLL K+ DFG+S+ D V ++ PE ++ T +SDV+ Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740 Query: 525 SFGVVMLEV 551 SFGV++ E+ Sbjct: 741 SFGVILWEI 749
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/189 (28%), Positives = 86/189 (45%), Gaps = 14/189 (7%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK + +F+ E E G C + + +I+V+EYM++G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 207 TVKSHL--YGSD------------NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 + L +G D L Q L I A G+ YL +++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 345 KSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVY 524 + N L+ NLL K+ DFG+S+ D V ++ PE ++ T +SDV+ Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740 Query: 525 SFGVVMLEV 551 SFGV++ E+ Sbjct: 741 SFGVILWEI 749
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 77.0 bits (188), Expect = 4e-14 Identities = 47/135 (34%), Positives = 77/135 (57%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G +R ++++ E+MENG + + L ++ L Q + + G A G++YL S Sbjct: 690 GVVTKRKPIMIITEFMENGALDAFLRERED-QLVPGQLVAMLQGIASGMNYL---SNHNY 745 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 +HRD+ + NIL+++NL KV+DFGL++ + D T+ + K + PE + T Sbjct: 746 VHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTT 805 Query: 510 KSDVYSFGVVMLEVL 554 SDV+SFG+VM EVL Sbjct: 806 ASDVWSFGIVMWEVL 820
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 77.0 bits (188), Expect = 4e-14 Identities = 56/173 (32%), Positives = 87/173 (50%), Gaps = 2/173 (1%) Frame = +3 Query: 39 KVAVK--RGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 KVA+K R S++ +F E E G C E+ + LV+E+ME+G + Sbjct: 387 KVAIKTIREGAMSEE---DFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCL 443 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 +L + + L +C+ G+ YL +IHRD+ + N L+ EN + KV+ Sbjct: 444 SDYLR-TQRGLFAAETLLGMCLDVCEGMAYLEEA---CVIHRDLAARNCLVGENQVIKVS 499 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 DFG+++ + DQ ST K + PE F + + KSDV+SFGV+M EV Sbjct: 500 DFGMTRFVLD-DQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEV 551
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + FR E+ +GY + N + +V ++ E ++ Sbjct: 371 DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 429 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + Q ++I A+G+ YLH AK IIHRD+KS NI L E L K+ Sbjct: 430 YKHLHVQET-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIG 485 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 486 DFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELM 542
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 76.6 bits (187), Expect = 6e-14 Identities = 46/135 (34%), Positives = 77/135 (57%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G +R ++++ E+MENG + + L ++ L Q + + +G A G++ L S Sbjct: 691 GVITKRKPIMIITEFMENGALDAFLKERED-QLAPGQLVAMLLGIASGMNCL---SGHNY 746 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 +HRD+ + NIL+++NL KV+DFGL++ + D T+ + K + PE + T Sbjct: 747 VHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTT 806 Query: 510 KSDVYSFGVVMLEVL 554 SDV+SFG+VM EVL Sbjct: 807 ASDVWSFGIVMWEVL 821
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 76.6 bits (187), Expect = 6e-14 Identities = 53/188 (28%), Positives = 85/188 (45%), Gaps = 14/188 (7%) Frame = +3 Query: 30 DDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGT 209 D VAVK + +F+ E E G C + + +I+V+EYM++G Sbjct: 567 DKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD 626 Query: 210 VKSHL--YGSD------------NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 + L +G D L Q L I A G+ YL +++ +HRD+ Sbjct: 627 LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLA 683 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N L+ NLL K+ DFG+S+ D V ++ PE ++ T +SDV+S Sbjct: 684 TRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS 743 Query: 528 FGVVMLEV 551 FGV++ E+ Sbjct: 744 FGVILWEI 751
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 76.3 bits (186), Expect = 8e-14 Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + FR E+ +GY + N + +V ++ E ++ Sbjct: 371 DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 429 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + Q ++I A+G+ YLH AK IIHRD+KS NI L E L K+ Sbjct: 430 YKHLHVQET-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIG 485 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 486 DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 542
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 76.3 bits (186), Expect = 8e-14 Identities = 45/129 (34%), Positives = 71/129 (55%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EY++ T++ ++ +D P + +Q +EI A + L++ H IIHRDVK ANI Sbjct: 90 IVMEYVDGATLRDIVH-TDGP-MPPQQAIEIVADACQALNFSHQNG---IIHRDVKPANI 144 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 ++ KV DFG+++ + + AV G+ YL PE R + +SDVYS G V Sbjct: 145 MISATNAVKVMDFGIARAIADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCV 204 Query: 540 MLEVLCARP 566 + E+L P Sbjct: 205 LYEILTGEP 213
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 75.5 bits (184), Expect = 1e-13 Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 14/189 (7%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK + +F+ E E G C + + +I+V+EYM++G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 207 TVKSHL--YGSD------------NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 + L +G D L Q L I A G+ YL +++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPXQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 345 KSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVY 524 + N + NLL K+ DFG+S+ D V ++ PE ++ T +SDV+ Sbjct: 681 ATRNCXVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740 Query: 525 SFGVVMLEV 551 SFGV++ E+ Sbjct: 741 SFGVILWEI 749
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 75.5 bits (184), Expect = 1e-13 Identities = 44/133 (33%), Positives = 72/133 (54%) Frame = +3 Query: 156 CDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIH 335 C +R + +V EYM G++ +L + +L +++ A G+ +L A+ IH Sbjct: 302 CSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLE---AQGYIH 358 Query: 336 RDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKS 515 RD+ + NIL+ EN + KVADFGL++ E D+ K + PE + T KS Sbjct: 359 RDLAARNILVGENYICKVADFGLARL-IEDDEYTAHEGAKFPIKWTAPEAALYNRFTIKS 417 Query: 516 DVYSFGVVMLEVL 554 DV+SFG++M E++ Sbjct: 418 DVWSFGILMAEIV 430
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 75.1 bits (183), Expect = 2e-13 Identities = 53/176 (30%), Positives = 84/176 (47%), Gaps = 1/176 (0%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 R +VA+K N S +F E + G C +R + +V E+MENG Sbjct: 291 RSHIQVAIKAINEGSMSE-EDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENG 349 Query: 207 TVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAK 386 + ++L + L + L +C G+ YL IHRD+ + N L+ + K Sbjct: 350 CLLNYLR-ENKGKLRKEMLLSVCQDICEGMEYLERNG---YIHRDLAARNCLVSSTCIVK 405 Query: 387 VADFGLSKTGPELDQTHVST-AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 ++DFG+++ LD +VS+ K + PE F + + KSDV+SFGV+M EV Sbjct: 406 ISDFGMTRY--VLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEV 459
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 75.1 bits (183), Expect = 2e-13 Identities = 51/165 (30%), Positives = 78/165 (47%) Frame = +3 Query: 81 LNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQ 260 + FR E + +E + +V EY+E T+K ++ + N L+ K+ Sbjct: 53 IRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYI--TANGPLHPKE 110 Query: 261 RLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHV 440 L I + + H I+HRD+K NIL+D KV DFG++ TH Sbjct: 111 ALNIMEQIVSAIAHAHQNQ---IVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHT 167 Query: 441 STAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 ++ V GS YL PE R T+KSD+Y+ G+V+ E+L R D Sbjct: 168 NS-VLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFD 211
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 75.1 bits (183), Expect = 2e-13 Identities = 54/173 (31%), Positives = 83/173 (47%) Frame = +3 Query: 36 TKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVK 215 T VAVK P + + EF E C + + +V E M++G++ Sbjct: 263 TSVAVKTLKPGTMS-IEEFLEEASIMKQLRHPKLIQLYAVCTKEEPIYIVTELMKHGSLL 321 Query: 216 SHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 +L G D SL +++C A G+ YL + IHRD+ + NIL+ E+ + KVAD Sbjct: 322 EYLRG-DGRSLKLPDLVDMCSQVASGMSYLEQQN---YIHRDLAARNILVGEHKICKVAD 377 Query: 396 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 FGL++ E + K + PE + T KSDV+SFG+V+ EV+ Sbjct: 378 FGLARVIDE-EIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVWSFGIVLYEVI 429
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 74.7 bits (182), Expect = 2e-13 Identities = 59/213 (27%), Positives = 101/213 (47%), Gaps = 6/213 (2%) Frame = +3 Query: 6 KSTRXALRDDTKVAV-----KRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERN 170 K+TR +DD+KV KRG ++ + L R E + I + + Sbjct: 20 KATR---KDDSKVVAIKVISKRG--RATKELKNLRRECDIQARLKHPHVIEMIESFESKT 74 Query: 171 EMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKS 350 ++ +V E+ + H Y S N ++ + + L+YLH+ I+HRD+K Sbjct: 75 DLFVVTEF---ALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNR---ILHRDLKP 128 Query: 351 ANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 N+LLD+N+ AK+ DFGL++ THV T++KG+ Y+ PE Q +D++S Sbjct: 129 QNVLLDKNMHAKLCDFGLARN--MTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSL 186 Query: 531 GVVMLEVLCARPVIDPSLPREMVNLAEW-GMKW 626 G + E + +P S +V + + +KW Sbjct: 187 GCIAYESMAGQPPFCASSILHLVKMIKHEDVKW 219
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 74.7 bits (182), Expect = 2e-13 Identities = 53/188 (28%), Positives = 87/188 (46%), Gaps = 13/188 (6%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK S+ +F+ E E G C E +++V+EYM +G Sbjct: 536 QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 595 Query: 207 TV----KSH------LYGSDNPS---LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 + +SH L G ++ + L Q L + A G+ YL + +HRD+ Sbjct: 596 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---AGLHFVHRDLA 652 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N L+ + L+ K+ DFG+S+ D V ++ PE ++ T +SDV+S Sbjct: 653 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWS 712 Query: 528 FGVVMLEV 551 FGVV+ E+ Sbjct: 713 FGVVLWEI 720
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 74.7 bits (182), Expect = 2e-13 Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 13/188 (6%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 ++ T VAVK ++ +F+ E E G C E + +I+V+EYM++G Sbjct: 519 QEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVKFYGVCTEGDPLIMVFEYMKHG 578 Query: 207 TVKSHL--YGSDNPSLNWKQ-----------RLEICIGAARGLHYLHTGSAKAIIHRDVK 347 + L +G D L+ Q L+I A G+ YL ++ +HRD+ Sbjct: 579 DLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQIASGMVYL---ASLHFVHRDLA 635 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N L+ +L+ K+ DFG+S+ D V ++ PE ++ T +SD++S Sbjct: 636 TRNCLVGHDLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWS 695 Query: 528 FGVVMLEV 551 FGVV+ E+ Sbjct: 696 FGVVLWEI 703
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 74.3 bits (181), Expect = 3e-13 Identities = 47/127 (37%), Positives = 70/127 (55%), Gaps = 1/127 (0%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 ++V EYMENG++ + L D Q + + G G+ YL S +HRD+ + N Sbjct: 710 MIVTEYMENGSLDTFLRTHDG-QFTIMQLVGMLRGVGAGMRYL---SDLGYVHRDLAARN 765 Query: 357 ILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 +L+D NL+ KV+DFGLS+ + D + +T K + PE + + SDV+SFG Sbjct: 766 VLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFG 825 Query: 534 VVMLEVL 554 VVM EVL Sbjct: 826 VVMWEVL 832
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 74.3 bits (181), Expect = 3e-13 Identities = 55/174 (31%), Positives = 85/174 (48%), Gaps = 1/174 (0%) Frame = +3 Query: 36 TKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVK 215 T VAVK P + + EF E C + + +V E M+ G++ Sbjct: 263 TSVAVKTLKPGTMS-VEEFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLL 321 Query: 216 SHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 +L G D L +Q +++ A G+ YL + IHRD+ + NIL+ E+ + KVAD Sbjct: 322 EYLRGEDGV-LKIEQLVDVAAQVASGMSYLEQQN---YIHRDLAARNILVGEHGICKVAD 377 Query: 396 FGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 FGL++ E+ + H T K + PE + T KSDV+SFGVV+ E++ Sbjct: 378 FGLARVIDEEIYEAH--TGAKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEII 429
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 74.3 bits (181), Expect = 3e-13 Identities = 55/188 (29%), Positives = 90/188 (47%), Gaps = 13/188 (6%) Frame = +3 Query: 30 DDTKVAVKRGNPKSQ--QGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMEN 203 D+ V R +P Q + R E + G C + + LV E+ Sbjct: 166 DEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARG 225 Query: 204 GTVKSHLYGSDNPS---LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDE- 371 G + L G P +NW ++ ARG++YLH + IIHRD+KS+NIL+ + Sbjct: 226 GPLNRVLSGKRIPPDILVNWAVQI------ARGMNYLHDEAIVPIIHRDLKSSNILILQK 279 Query: 372 -------NLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 N + K+ DFGL++ E +T +A G++ ++ PE R ++ SDV+S+ Sbjct: 280 VENGDLSNKILKITDFGLAR---EWHRTTKMSAA-GTYAWMAPEVIRASMFSKGSDVWSY 335 Query: 531 GVVMLEVL 554 GV++ E+L Sbjct: 336 GVLLWELL 343
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/136 (33%), Positives = 75/136 (55%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + M+++ EYMENG + L D + Q + + G A G+ YL + Sbjct: 680 GVISKYKPMMIITEYMENGALDKFLREKDG-EFSVLQLVGMLRGIAAGMKYLANMN---Y 735 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + T+ ++ K + PE ++ T Sbjct: 736 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFT 795 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+SFG+VM EV+ Sbjct: 796 SASDVWSFGIVMWEVM 811
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/160 (28%), Positives = 83/160 (51%), Gaps = 1/160 (0%) Frame = +3 Query: 156 CDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIH 335 C + + +V EYM G++ L D L+++ + I A G+ YL + K +IH Sbjct: 346 CSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLES---KQLIH 402 Query: 336 RDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKS 515 RD+ + N+L+ EN +AK+ DFGL++ + D+ + + PE + + KS Sbjct: 403 RDLAARNVLIGENNVAKICDFGLARVIAD-DEYCPKQGSRFPVKWTAPEAIIYGKFSIKS 461 Query: 516 DVYSFGVVMLEVLCARPVIDPSL-PREMVNLAEWGMKWQK 632 DV+S+G++++E+ V P + RE++ E G + K Sbjct: 462 DVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPK 501
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 74.3 bits (181), Expect = 3e-13 Identities = 51/184 (27%), Positives = 83/184 (45%), Gaps = 14/184 (7%) Frame = +3 Query: 42 VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSH 221 VAVK + +F+ E E G C + + +I+V+EYM++G + Sbjct: 569 VAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKF 628 Query: 222 L--YGSD------------NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 L +G D L Q L I G+ YL +++ +HRD+ + N Sbjct: 629 LRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQICSGMVYL---ASQHFVHRDLATRNC 685 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ NLL K+ DFG+S+ D V ++ PE ++ T +SDV+SFGV+ Sbjct: 686 LVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVI 745 Query: 540 MLEV 551 + E+ Sbjct: 746 LWEI 749
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/166 (30%), Positives = 79/166 (47%), Gaps = 11/166 (6%) Frame = +3 Query: 87 EFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDN--PSLNWKQ 260 EF TE IG +++V EYM NG++ L +D ++W++ Sbjct: 761 EFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEK 820 Query: 261 RLEICIGAARGLHYLHTGSAKAIIHR-----DVKSANILLDENLLAKVADFGLSK----T 413 E+ G A G+ YL + +HR D+ + N+LLD L K+ADFGLS+ Sbjct: 821 ITEMLYGIASGMKYL---TDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSRGVRSE 877 Query: 414 GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 G ++ + + K + PE ++ T SDV+SFGVV+ EV Sbjct: 878 GSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEV 923
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 73.9 bits (180), Expect = 4e-13 Identities = 48/144 (33%), Positives = 74/144 (51%), Gaps = 11/144 (7%) Frame = +3 Query: 156 CDERNEMILVYEYMENGTVKSHLYGSDNPS---LNWKQRLEICIGAARGLHYLHTGSAKA 326 C E + LV EY G + L G P +NW ++ ARG+HYLH + Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQI------ARGMHYLHCEALVP 236 Query: 327 IIHRDVKSANILL--------DENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPE 482 +IHRD+KS NILL E+ K+ DFGL++ + Q + G++ ++ PE Sbjct: 237 VIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQ----MSAAGTYAWMAPE 292 Query: 483 YFRRQQLTEKSDVYSFGVVMLEVL 554 + ++ SDV+SFGV++ E+L Sbjct: 293 VIKASTFSKGSDVWSFGVLLWELL 316
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 3/177 (1%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D V + + + + FR E+ +GY + N + +V ++ E ++ Sbjct: 104 DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL 162 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 HL+ + Q ++I A+G+ YLH AK IIHRD+KS NI L L K+ Sbjct: 163 YKHLHVQET-KFQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHGGLTVKIG 218 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 DFGL+ + GS ++ PE R Q + +SDVYS+G+V+ E++ Sbjct: 219 DFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELM 275
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 73.9 bits (180), Expect = 4e-13 Identities = 56/216 (25%), Positives = 102/216 (47%), Gaps = 17/216 (7%) Frame = +3 Query: 36 TKVAVKR-GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXI-GYCDERNEMILVYEYMENGT 209 TKVAVK + +++ L++ +E+E + G C + + ++ EY G Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 210 VKSHLYGSDNPSLNW--------------KQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 ++ +L P L + K + ARG+ YL ++K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL---ASKKCIHRDLA 625 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N+L+ E+ + K+ADFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 528 FGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 FGV++ E+ +P +P E+ L + G + K Sbjct: 686 FGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDK 721
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 73.6 bits (179), Expect = 5e-13 Identities = 57/216 (26%), Positives = 103/216 (47%), Gaps = 17/216 (7%) Frame = +3 Query: 36 TKVAVKR-GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXI-GYCDERNEMILVYEYMENGT 209 TKVAVK + S++ L++ +E+E + G C + + ++ EY G Sbjct: 503 TKVAVKMLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGN 562 Query: 210 VKSHLYGSDNPS--------------LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 ++ +L P+ L++K + ARG+ YL ++K IHRD+ Sbjct: 563 LREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYL---ASKKCIHRDLA 619 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N+L+ E+ + K+ADFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 620 ARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 679 Query: 528 FGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 FGV++ E+ P +P E+ L + G + K Sbjct: 680 FGVLLWEIFTLGGSPYPGVPMEELFKLLKEGHRMDK 715
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 73.6 bits (179), Expect = 5e-13 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 1/157 (0%) Frame = +3 Query: 84 NEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQR 263 +EF E + G C + + +V EY+ NG + ++L S L Q Sbjct: 455 DEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLR-SHGKGLEPSQL 513 Query: 264 LEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVS 443 LE+C G+ +L + IHRD+ + N L+D +L KV+DFG+++ LD +VS Sbjct: 514 LEMCYDVCEGMAFLESHQ---FIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVS 568 Query: 444 T-AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 + K + PE F + + KSDV++FG++M EV Sbjct: 569 SVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEV 605
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/174 (28%), Positives = 86/174 (49%), Gaps = 3/174 (1%) Frame = +3 Query: 39 KVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKS 218 K + + K+QQ +F+ EIE +G + +++EYM NG + Sbjct: 442 KALKENASVKTQQ---DFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHE 498 Query: 219 HLYGS---DNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 L + + SL+ + L+I + + G+ YL SA +HRD+ + N L++E L+ K+ Sbjct: 499 FLISNSPTEGKSLSQLEFLQIALQISEGMQYL---SAHHYVHRDLAARNCLVNEGLVVKI 555 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 +DFGLS+ D V + ++ E + T +SDV+SFGVV+ E+ Sbjct: 556 SDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEI 609
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 73.6 bits (179), Expect = 5e-13 Identities = 58/200 (29%), Positives = 91/200 (45%), Gaps = 19/200 (9%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLE 269 F TE++ IG + ++ L+ EY+E GT+K L +D W+Q++ Sbjct: 373 FLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNAD--PFPWQQKVS 430 Query: 270 ICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS------KTGPELDQ 431 G A G+ YLH+ IIHRD+ S N L+ + VADFGLS + P L++ Sbjct: 431 FAKGIASGMAYLHS---MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPTLEK 487 Query: 432 THVST------------AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 V G+ ++ PE Q E D++SFG+V+ E++ + D Sbjct: 488 PSAKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGQSYDETVDIFSFGIVLCEII-GQVYAD 546 Query: 576 PS-LPREMVNLAEWGMKWQK 632 P LPR + + W+K Sbjct: 547 PDCLPRTLDFGLNVKLFWEK 566
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 73.2 bits (178), Expect = 6e-13 Identities = 49/135 (36%), Positives = 71/135 (52%), Gaps = 6/135 (4%) Frame = +3 Query: 180 LVYEYMENGTVKS--HLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +V EY++ T++ H G P K+ +E+ A + L++ H IIHRDVK A Sbjct: 90 IVMEYVDGVTLRDIVHTEGPMTP----KRAIEVIADACQALNFSHQNG---IIHRDVKPA 142 Query: 354 NILLDENLLAKVADFGLSK----TGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDV 521 NI++ KV DFG+++ +G + QT AV G+ YL PE R + +SDV Sbjct: 143 NIMISATNAVKVMDFGIARAIADSGNSVTQT---AAVIGTAQYLSPEQARGDSVDARSDV 199 Query: 522 YSFGVVMLEVLCARP 566 YS G V+ EVL P Sbjct: 200 YSLGCVLYEVLTGEP 214
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 73.2 bits (178), Expect = 6e-13 Identities = 49/135 (36%), Positives = 71/135 (52%), Gaps = 6/135 (4%) Frame = +3 Query: 180 LVYEYMENGTVKS--HLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +V EY++ T++ H G P K+ +E+ A + L++ H IIHRDVK A Sbjct: 90 IVMEYVDGVTLRDIVHTEGPMTP----KRAIEVIADACQALNFSHQNG---IIHRDVKPA 142 Query: 354 NILLDENLLAKVADFGLSK----TGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDV 521 NI++ KV DFG+++ +G + QT AV G+ YL PE R + +SDV Sbjct: 143 NIMISATNAVKVMDFGIARAIADSGNSVTQT---AAVIGTAQYLSPEQARGDSVDARSDV 199 Query: 522 YSFGVVMLEVLCARP 566 YS G V+ EVL P Sbjct: 200 YSLGCVLYEVLTGEP 214
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 73.2 bits (178), Expect = 6e-13 Identities = 56/152 (36%), Positives = 78/152 (51%), Gaps = 5/152 (3%) Frame = +3 Query: 159 DERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHR 338 D+ + LV ++MENG++ S L S P W + G+ YLH + ++HR Sbjct: 85 DQDPKPALVTKFMENGSL-SGLLQSQCPR-PWPLLCRLLKEVVLGMFYLHDQNP-VLLHR 141 Query: 339 DVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYF--RRQQLTEK 512 D+K +N+L D L K+ADFGLS S G+ GYL PE F ++ + Sbjct: 142 DLKPSNVLPDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTA 201 Query: 513 SDVYSFGVVMLEVLCARPV---IDPSLPREMV 599 SDVYSFG++M VL R V +PSL E V Sbjct: 202 SDVYSFGILMWAVLAGREVELPTEPSLVYEAV 233
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 73.2 bits (178), Expect = 6e-13 Identities = 51/148 (34%), Positives = 80/148 (54%), Gaps = 12/148 (8%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ EYMENG++ + L +D Q + I G A G+ YL S + +HRD+ + Sbjct: 69 VMIITEYMENGSLDAFLRKNDG-RFTVIQLVGILRGIASGMKYL---SDMSYVHRDLAAR 124 Query: 354 NILLDENLLAKVADFGLSK----------TGPELDQTHVSTAVKGSFGYLDPEYFRRQQL 503 NIL++ NL+ KV+DFG+S+ T E+ T+ S K + PE ++ Sbjct: 125 NILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKF 184 Query: 504 TEKSDVYSFGVVMLEVLC--ARPVIDPS 581 T SDV+S+G+VM EV+ RP D S Sbjct: 185 TSASDVWSYGIVMWEVMSYGERPYWDMS 212
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 73.2 bits (178), Expect = 6e-13 Identities = 45/136 (33%), Positives = 75/136 (55%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + M+++ EYMENG + L D + Q + + G A G+ YL + Sbjct: 681 GVVSKYKPMMIITEYMENGALDKFLREKDG-EFSVLQLVGMLRGIASGMKYLANMN---Y 736 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + T+ ++ K + PE ++ T Sbjct: 737 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFT 796 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+VM EV+ Sbjct: 797 SASDVWSYGIVMWEVM 812
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 73.2 bits (178), Expect = 6e-13 Identities = 55/153 (35%), Positives = 77/153 (50%), Gaps = 14/153 (9%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 +G E LV EYME G + L + L+ K R I + A G+ YLH K Sbjct: 79 LGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGR--IIVEAIEGMCYLHD---KG 133 Query: 327 IIHRDVKSANILLDENLLAKVADFGL------SKTGPELD--QTHVSTAVK----GSFGY 470 +IH+D+K NIL+D + K+AD G+ SK E D Q VS+ K G+ Y Sbjct: 134 VIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYY 193 Query: 471 LDPEYFR--RQQLTEKSDVYSFGVVMLEVLCAR 563 + PE+ + TEKSDVYSFG+V+ + + Sbjct: 194 MAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKK 226
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 73.2 bits (178), Expect = 6e-13 Identities = 49/148 (33%), Positives = 76/148 (51%), Gaps = 13/148 (8%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPS---LNWKQRLEICIGAARGLHYLHTGSA 320 G C + LV EY G + L G P +NW + ARG++YLH + Sbjct: 162 GACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNW------AVQVARGMNYLHNDAP 215 Query: 321 KAIIHRDVKSANILLDE--------NLLAKVADFGLSKTGPELDQTHVST--AVKGSFGY 470 IIHRD+KS NIL+ E + + K+ DFGL++ + H +T + G++ + Sbjct: 216 VPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR------EWHKTTKMSAAGTYAW 269 Query: 471 LDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 + PE R ++ SDV+SFGV++ E+L Sbjct: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELL 297
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 73.2 bits (178), Expect = 6e-13 Identities = 52/188 (27%), Positives = 87/188 (46%), Gaps = 13/188 (6%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK S+ +F E E G C E +++V+EYM +G Sbjct: 539 QDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHG 598 Query: 207 TV----KSH------LYGSDNPS---LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 + +SH L G ++ + L Q L + A G+ YL ++ +HRD+ Sbjct: 599 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---ASLHFVHRDLA 655 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N L+ + L+ K+ DFG+S+ D V ++ PE ++ + +SDV+S Sbjct: 656 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWS 715 Query: 528 FGVVMLEV 551 FGVV+ E+ Sbjct: 716 FGVVLWEI 723
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 72.8 bits (177), Expect = 8e-13 Identities = 48/177 (27%), Positives = 86/177 (48%) Frame = +3 Query: 24 LRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMEN 203 + D +VAVK+ L + E E G E +V EY Sbjct: 36 ISQDKEVAVKK--------LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASL 87 Query: 204 GTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLA 383 G++ ++ + + ++ + + A+G+HYLH + +IHRD+KS N+++ + + Sbjct: 88 GSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVL 147 Query: 384 KVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 K+ DFG S+ TH+S + G+F ++ PE + ++E D YS+GVV+ E+L Sbjct: 148 KICDFGASRF--HNHTTHMS--LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEML 200
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 72.8 bits (177), Expect = 8e-13 Identities = 54/159 (33%), Positives = 86/159 (54%), Gaps = 5/159 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + ++++ E+MENG + S L +D Q + + G A G+ YL S Sbjct: 603 GVVTKSRPVMIITEFMENGALDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---SEMNY 658 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S+ K + PE R ++ Sbjct: 659 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIRYRK 718 Query: 501 LTEKSDVYSFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 T SDV+S+G+VM EV+ RP D S ++++N E Sbjct: 719 FTSASDVWSYGIVMWEVMSYGERPYWDMS-NQDVINAIE 756
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/141 (34%), Positives = 74/141 (52%), Gaps = 3/141 (2%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHL--YGSDNPSLNWKQRLEICIGAARGLHYLHTGSAK 323 G E + + EY+ G+V S L YG SL +I IG A YLH K Sbjct: 542 GASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVA----YLHK---K 594 Query: 324 AIIHRDVKSANILLDENLLAKVADFGLS-KTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ 500 IIHRD+K ANIL+D K+ DFG+S K P + + +++GS ++ PE ++ Sbjct: 595 NIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTA 654 Query: 501 LTEKSDVYSFGVVMLEVLCAR 563 T K+D++S G V++E+ + Sbjct: 655 TTAKADIWSTGCVVIEMFTGK 675
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/157 (31%), Positives = 80/157 (50%), Gaps = 1/157 (0%) Frame = +3 Query: 84 NEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQR 263 +EF E + G C ++ + +V EY+ NG + ++L S L Q Sbjct: 431 DEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLK-SHGKGLESCQL 489 Query: 264 LEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVS 443 LE+C G+ +L + IHRD+ + N L+D +L KV+DFG+++ LD +VS Sbjct: 490 LEMCYDVCEGMAFLESHQ---FIHRDLAARNCLVDSDLSVKVSDFGMTRY--VLDDQYVS 544 Query: 444 T-AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEV 551 + K + PE F + + KSDV++FG++M EV Sbjct: 545 SVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEV 581
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 72.4 bits (176), Expect = 1e-12 Identities = 56/183 (30%), Positives = 90/183 (49%), Gaps = 7/183 (3%) Frame = +3 Query: 24 LRDDTK--VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDE--RNEMILVYE 191 L+D+T VAVK+ +++ L +F EIE G C R + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME 930 Query: 192 YMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDE 371 Y+ G+++ +L ++ K+ L+ +G+ YL T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 372 NLLAKVADFGLSKTGPELDQTHVSTAVKGS---FGYLDPEYFRRQQLTEKSDVYSFGVVM 542 K+ DFGL+K P+ D+ + G F Y PE + + SDV+SFGVV+ Sbjct: 987 ENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYA-PESLTESKFSVASDVWSFGVVL 1044 Query: 543 LEV 551 E+ Sbjct: 1045 YEL 1047 Score = 38.5 bits (88), Expect = 0.017 Identities = 40/143 (27%), Positives = 71/143 (49%), Gaps = 9/143 (6%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C E ILV E+++ G++ ++L + N S+N +L + A +H+L K++ Sbjct: 614 GVCVCGEENILVQEFVKFGSLDTYLKKNKN-SINILWKLGVAKQLAWAMHFL---EEKSL 669 Query: 330 IHRDVKSANILL--DENL------LAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 485 IH +V + NILL +E+ K++D G+S T D ++ ++ PE Sbjct: 670 IHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD------ILQERIPWVPPEC 723 Query: 486 FRR-QQLTEKSDVYSFGVVMLEV 551 + LT +D +SFG + E+ Sbjct: 724 IENPKNLTLATDKWSFGTTLWEI 746
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 72.4 bits (176), Expect = 1e-12 Identities = 56/216 (25%), Positives = 102/216 (47%), Gaps = 17/216 (7%) Frame = +3 Query: 36 TKVAVKR-GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXI-GYCDERNEMILVYEYMENGT 209 TKVAVK + +++ L++ +E+E + G C + + ++ EY G Sbjct: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 566 Query: 210 VKSHLYGSDNPS--------------LNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 ++ +L P L++K + ARG+ YL ++K IHRD+ Sbjct: 567 LREYLQARRPPGMEYCYNPTRIPEEQLSFKDLVSCAYQVARGMEYL---ASKKCIHRDLA 623 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N+L+ E+ + K+ADFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 624 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 683 Query: 528 FGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 FGV++ E+ P +P E+ L + G + K Sbjct: 684 FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 719
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 72.4 bits (176), Expect = 1e-12 Identities = 48/139 (34%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V EYMENG + + L D Q + + G A G+ YL + +HRD+ + Sbjct: 702 VMIVIEYMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYL---ADMGYVHRDLAAR 757 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE + ++ T SDV+S+ Sbjct: 758 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 817 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 818 GIVMWEVMSYGERPYWDMS 836
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 72.4 bits (176), Expect = 1e-12 Identities = 43/127 (33%), Positives = 72/127 (56%), Gaps = 1/127 (0%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + +V E++ G + + L +N Q L+ + A G+ YL + K ++HRD+ + Sbjct: 300 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLES---KKLVHRDLAAR 356 Query: 354 NILLDENLLAKVADFGLSKTGPE-LDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL+ E+L+AKV+DFGL+K + LD + + + PE + + T KSDV+SF Sbjct: 357 NILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK------WTAPEALKHGKFTSKSDVWSF 410 Query: 531 GVVMLEV 551 GV++ EV Sbjct: 411 GVLLWEV 417
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 72.4 bits (176), Expect = 1e-12 Identities = 54/140 (38%), Positives = 74/140 (52%), Gaps = 5/140 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C R + LV EYME G+++ L P W R I A G+++LH A + Sbjct: 86 GIC--REPVGLVMEYMETGSLEKLLASEPLP---WDLRFRIIHETAVGMNFLHC-MAPPL 139 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFG---YLDPEYFRRQQ 500 +H D+K ANILLD + K++DFGL+K L +H ++ G FG YL PE R + Sbjct: 140 LHLDLKPANILLDAHYHVKISDFGLAKCN-GLSHSH-DLSMDGLFGTIAYLPPERIREKS 197 Query: 501 --LTEKSDVYSFGVVMLEVL 554 K DVYSF +V+ VL Sbjct: 198 RLFDTKHDVYSFAIVIWGVL 217
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 72.4 bits (176), Expect = 1e-12 Identities = 48/160 (30%), Positives = 73/160 (45%) Frame = +3 Query: 87 EFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRL 266 +FR E+E GY + + L+ EY+ NG + HL G + N Sbjct: 153 QFRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSH--FNDVVAS 210 Query: 267 EICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVST 446 A L Y+H + I+HRD+K NI++ N K+ DFG S P+ + Sbjct: 211 YYVYQMADALDYMHE---RNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSKRKT-- 265 Query: 447 AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARP 566 + G+ YL PE R ++ EK DV++ GV+ E+L P Sbjct: 266 -LCGTVDYLSPELIRSREYNEKVDVWALGVLTYELLVGSP 304
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 72.4 bits (176), Expect = 1e-12 Identities = 56/216 (25%), Positives = 101/216 (46%), Gaps = 17/216 (7%) Frame = +3 Query: 36 TKVAVKR-GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXI-GYCDERNEMILVYEYMENGT 209 TKVAVK + +++ L++ +E+E + G C + + ++ EY G Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 210 VKSHLYGSDNPSLNW--------------KQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 ++ +L P L + K + ARG+ YL ++K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL---ASKKCIHRDLA 625 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N+L+ E+ + K+ADFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 528 FGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 FGV++ E+ P +P E+ L + G + K Sbjct: 686 FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 721
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 72.4 bits (176), Expect = 1e-12 Identities = 56/216 (25%), Positives = 101/216 (46%), Gaps = 17/216 (7%) Frame = +3 Query: 36 TKVAVKR-GNPKSQQGLNEFRTEIEXXXXXXXXXXXXXI-GYCDERNEMILVYEYMENGT 209 TKVAVK + +++ L++ +E+E + G C + + ++ EY G Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 210 VKSHLYGSDNPSLNW--------------KQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 ++ +L P L + K + ARG+ YL ++K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL---ASKKCIHRDLA 625 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 + N+L+ E+ + K+ADFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 528 FGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 FGV++ E+ P +P E+ L + G + K Sbjct: 686 FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 721
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 72.0 bits (175), Expect = 1e-12 Identities = 48/177 (27%), Positives = 85/177 (48%) Frame = +3 Query: 24 LRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMEN 203 + D +VAVK+ L + E E G E +V EY Sbjct: 36 ISQDKEVAVKK--------LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASL 87 Query: 204 GTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLA 383 G++ ++ + + ++ + A+G+HYLH + +IHRD+KS N+++ + + Sbjct: 88 GSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVL 147 Query: 384 KVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 K+ DFG S+ TH+S + G+F ++ PE + ++E D YS+GVV+ E+L Sbjct: 148 KICDFGASRF--HNHTTHMS--LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEML 200
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 72.0 bits (175), Expect = 1e-12 Identities = 57/164 (34%), Positives = 83/164 (50%), Gaps = 14/164 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 IG + + + EY++ GT++ + D+ W QR+ A G+ YLH+ + Sbjct: 400 IGVLYKDKRLNFITEYIKGGTLRGIIKSMDS-QYPWSQRVSFAKDIASGMAYLHSMN--- 455 Query: 327 IIHRDVKSANILLDENLLAKVADFGLS------KTGPE-------LDQTHVSTAVKGSFG 467 IIHRD+ S N L+ EN VADFGL+ KT PE D+ T V G+ Sbjct: 456 IIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV-GNPY 514 Query: 468 YLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPS-LPREM 596 ++ PE + EK DV+SFG+V+ E++ R DP LPR M Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYLPRTM 557
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 72.0 bits (175), Expect = 1e-12 Identities = 46/156 (29%), Positives = 79/156 (50%), Gaps = 1/156 (0%) Frame = +3 Query: 159 DERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHR 338 +E++ + +V EYM G++ +L L L+ + + YL A +HR Sbjct: 257 EEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---ANNFVHR 313 Query: 339 DVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSD 518 D+ + N+L+ E+ +AKV+DFGL+K T K + PE R ++ + KSD Sbjct: 314 DLAARNVLVSEDNIAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSD 368 Query: 519 VYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMK 623 V+SFG+++ E+ V P +P +++V E G K Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 72.0 bits (175), Expect = 1e-12 Identities = 55/176 (31%), Positives = 95/176 (53%), Gaps = 5/176 (2%) Frame = +3 Query: 42 VAVKRGNPK---SQQGLNEFRTEIEXXXXXXXXXXXXXIGYC-DERNEMILVYEYMENGT 209 VA+KR S+ ++ F E+ +G C D+ ++ +V +Y+ G+ Sbjct: 485 VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGS 544 Query: 210 VKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 + S L+ L+ + +L I + A+G+ YLH+ + IIHRD+ S NILL E+ A V Sbjct: 545 LFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVV 602 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRR-QQLTEKSDVYSFGVVMLEVL 554 ADFG S+ LD+ ++ T G+ ++ PE F + + T K+DV+S+ + + E+L Sbjct: 603 ADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELL 657
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 72.0 bits (175), Expect = 1e-12 Identities = 45/128 (35%), Positives = 73/128 (57%), Gaps = 1/128 (0%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V EYMENG++ S L D Q + + G A G+ YL S +HRD+ + Sbjct: 746 VMIVVEYMENGSLDSFLRKHDG-HFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAAR 801 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE ++ + SDV+S+ Sbjct: 802 NILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDVWSY 861 Query: 531 GVVMLEVL 554 G+VM EV+ Sbjct: 862 GIVMWEVM 869
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 72.0 bits (175), Expect = 1e-12 Identities = 42/130 (32%), Positives = 72/130 (55%) Frame = +3 Query: 165 RNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 + + ++ EYME G++ L S+ L+ + L++ A G+ ++ AK IHRD+ Sbjct: 307 KEPIYIITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIE---AKNYIHRDL 363 Query: 345 KSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVY 524 ++ANIL+ E L K+ADFGL++ + + T K + PE T KSDV+ Sbjct: 364 RAANILVSEALCCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVW 422 Query: 525 SFGVVMLEVL 554 SFG+++ E++ Sbjct: 423 SFGILLTEIV 432
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 72.0 bits (175), Expect = 1e-12 Identities = 55/176 (31%), Positives = 95/176 (53%), Gaps = 5/176 (2%) Frame = +3 Query: 42 VAVKRGNPK---SQQGLNEFRTEIEXXXXXXXXXXXXXIGYC-DERNEMILVYEYMENGT 209 VA+KR S+ ++ F E+ +G C D+ ++ +V +Y+ G+ Sbjct: 486 VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGS 545 Query: 210 VKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 + S L+ L+ + +L I + A+G+ YLH+ + IIHRD+ S NILL E+ A V Sbjct: 546 LFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVV 603 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRR-QQLTEKSDVYSFGVVMLEVL 554 ADFG S+ LD+ ++ T G+ ++ PE F + + T K+DV+S+ + + E+L Sbjct: 604 ADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYSLCLWELL 658
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/182 (30%), Positives = 93/182 (51%), Gaps = 7/182 (3%) Frame = +3 Query: 30 DDTKV--AVKRGNPKSQQG-LNEFRTEIEXXXXXXXXXXXXXIGYC-DERNEMILVYEYM 197 DD K+ AVK N + G +++F TE +G C ++V YM Sbjct: 1101 DDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYM 1160 Query: 198 ENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDEN 374 ++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + N +LDE Sbjct: 1161 KHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEK 1215 Query: 375 LLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLE 548 KVADFGL++ E H T K ++ E + Q+ T KSDV+SFGV++ E Sbjct: 1216 FTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWE 1275 Query: 549 VL 554 ++ Sbjct: 1276 LM 1277
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/182 (30%), Positives = 93/182 (51%), Gaps = 7/182 (3%) Frame = +3 Query: 30 DDTKV--AVKRGNPKSQQG-LNEFRTEIEXXXXXXXXXXXXXIGYC-DERNEMILVYEYM 197 DD K+ AVK N + G +++F TE +G C ++V YM Sbjct: 1101 DDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYM 1160 Query: 198 ENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDEN 374 ++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + N +LDE Sbjct: 1161 KHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEK 1215 Query: 375 LLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLE 548 KVADFGL++ E H T K ++ E + Q+ T KSDV+SFGV++ E Sbjct: 1216 FTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWE 1275 Query: 549 VL 554 ++ Sbjct: 1276 LM 1277
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 71.6 bits (174), Expect = 2e-12 Identities = 43/129 (33%), Positives = 75/129 (58%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1155 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1209 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDEN KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1210 NCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1269 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1270 FGVLLWELM 1278
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/182 (30%), Positives = 93/182 (51%), Gaps = 7/182 (3%) Frame = +3 Query: 30 DDTKV--AVKRGNPKSQQG-LNEFRTEIEXXXXXXXXXXXXXIGYC-DERNEMILVYEYM 197 DD K+ AVK N + G +++F TE +G C ++V YM Sbjct: 1102 DDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYM 1161 Query: 198 ENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDEN 374 ++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + N +LDE Sbjct: 1162 KHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAARNCMLDEK 1216 Query: 375 LLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLE 548 KVADFGL++ E H T K ++ E + Q+ T KSDV+SFGV++ E Sbjct: 1217 FTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWE 1276 Query: 549 VL 554 ++ Sbjct: 1277 LM 1278
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 71.6 bits (174), Expect = 2e-12 Identities = 47/176 (26%), Positives = 89/176 (50%), Gaps = 3/176 (1%) Frame = +3 Query: 36 TKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVK 215 T VAVK P S N+F E + C + + ++ E M +G+++ Sbjct: 257 TPVAVKTLKPGSMDP-NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQ 315 Query: 216 SHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVAD 395 +L ++ Q++++ A G+ YL + + IHRD+ + N+L+ E+ + KVAD Sbjct: 316 EYLQNDTGSKIHLTQQVDMAAQVASGMAYLES---RNYIHRDLAARNVLVGEHNIYKVAD 372 Query: 396 FGLSKTGPELDQTHVSTA---VKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 FGL++ ++D + + +K + PE R + + KSDV+SFG+++ E++ Sbjct: 373 FGLARVF-KVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEII 427
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/136 (33%), Positives = 75/136 (55%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ + L +D Q + + G A G+ YL S Sbjct: 717 GVVTKSKPVMIVTEYMENGSLDTFLKKNDG-QFTVIQLVGMLRGIASGMKYL---SDMGY 772 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 773 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFT 832 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+VM EV+ Sbjct: 833 SASDVWSYGIVMWEVM 848
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 71.6 bits (174), Expect = 2e-12 Identities = 44/135 (32%), Positives = 70/135 (51%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C + ++ EY +G + L + + ++ G A G++YLH I Sbjct: 221 GVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHK---I 275 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 IHRD+KS N+L+ K++DFG SK EL + G+ +L PE R + ++E Sbjct: 276 IHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTKMSFAGTVAWLAPEVIRNEPVSE 332 Query: 510 KSDVYSFGVVMLEVL 554 K D++SFGVV+ E+L Sbjct: 333 KVDIWSFGVVLWELL 347
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ S L D Q + + G A G+ YL S Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHD-AQFTVIQLVGMLRGIASGMKYL---SDMGY 742 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 743 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFT 802 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+V+ EV+ Sbjct: 803 SASDVWSYGIVLWEVM 818
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 4/129 (3%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V E+M NG+++ L SL WK R I + +++LH+ ++H D+K NI Sbjct: 96 IVMEFMANGSLEKVL---STHSLCWKLRFRIIHETSLAMNFLHS-IKPPLLHLDLKPGNI 151 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHV--STAVKGSFGYLDPEYFRRQQLT--EKSDVYS 527 LLD N+ K++DFGLSK + + +A++G Y+ PE F K DVYS Sbjct: 152 LLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYS 211 Query: 528 FGVVMLEVL 554 F +V+ E+L Sbjct: 212 FAIVIWELL 220
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/136 (33%), Positives = 75/136 (55%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ + L +D Q + + G A G+ YL S Sbjct: 743 GVVTKSKPVMIVTEYMENGSLDTFLKKNDG-QFTVIQLVGMLRGIAAGMKYL---SDMGY 798 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 799 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFT 858 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+VM EV+ Sbjct: 859 SASDVWSYGIVMWEVV 874
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 71.2 bits (173), Expect = 2e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 338 IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 394 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 395 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 453 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 454 LTELTTKGRVPYPGMVNREVLDQVERGYR 482
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 71.2 bits (173), Expect = 2e-12 Identities = 55/183 (30%), Positives = 90/183 (49%), Gaps = 7/183 (3%) Frame = +3 Query: 24 LRDDTK--VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDE--RNEMILVYE 191 L+D+T VAVK+ +++ L +F EIE G C R + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME 930 Query: 192 YMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDE 371 Y+ G+++ +L ++ K+ L+ +G+ YL T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 372 NLLAKVADFGLSKTGPELDQTHVSTAVKGS---FGYLDPEYFRRQQLTEKSDVYSFGVVM 542 K+ DFGL+K P+ D+ + G F Y P+ + + SDV+SFGVV+ Sbjct: 987 ENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYA-PQSLTESKFSVASDVWSFGVVL 1044 Query: 543 LEV 551 E+ Sbjct: 1045 YEL 1047 Score = 36.6 bits (83), Expect = 0.066 Identities = 39/143 (27%), Positives = 70/143 (48%), Gaps = 9/143 (6%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C E ILV E+++ G++ ++L + N S+N +L + A +H+L K++ Sbjct: 614 GVCVCGEENILVQEFVKFGSLDTYLKKNKN-SINILWKLGVAKQLAWAMHFL---EEKSL 669 Query: 330 IHRDVKSANILL--DENL------LAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 485 IH +V + NILL +E+ K++D G+S T D ++ ++ PE Sbjct: 670 IHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKD------ILQERIPWVPPEC 723 Query: 486 FRR-QQLTEKSDVYSFGVVMLEV 551 + L +D +SFG + E+ Sbjct: 724 IENPKNLNLATDKWSFGTTLWEI 746
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/136 (33%), Positives = 75/136 (55%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ + L +D Q + + G A G+ YL S Sbjct: 580 GVVTKSKPVMIVTEYMENGSLDTFLKKNDG-QFTVIQLVGMLRGIAAGMKYL---SDMGY 635 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 636 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFT 695 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+VM EV+ Sbjct: 696 SASDVWSYGIVMWEVV 711
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/128 (35%), Positives = 72/128 (56%), Gaps = 1/128 (0%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V EYMENG++ + L D Q L + G A G+ YL S +HRD+ + Sbjct: 700 VMIVTEYMENGSLDTFLKKHDG-QFTVIQLLGMLRGIAAGMQYL---SEMNYVHRDLAAR 755 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T SDV+S+ Sbjct: 756 NILVNRNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSY 815 Query: 531 GVVMLEVL 554 G+VM EV+ Sbjct: 816 GIVMWEVI 823
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/177 (26%), Positives = 84/177 (47%), Gaps = 15/177 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNW--------------KQRLEICIGA 284 +G C + + ++ EY G ++ +L P + + K + Sbjct: 551 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL 610 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL +++ IHRD+ + N+L+ EN + K+ADFGL++ +D +T + Sbjct: 611 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 667 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 ++ PE + T +SDV+SFGV+M E+ P +P E+ L + G + K Sbjct: 668 KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 724
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/177 (26%), Positives = 84/177 (47%), Gaps = 15/177 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNW--------------KQRLEICIGA 284 +G C + + ++ EY G ++ +L P + + K + Sbjct: 551 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL 610 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL +++ IHRD+ + N+L+ EN + K+ADFGL++ +D +T + Sbjct: 611 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 667 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 ++ PE + T +SDV+SFGV+M E+ P +P E+ L + G + K Sbjct: 668 KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 724
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 451 LTELTTKGRVPYPGMVNREVLDQVERGYR 479
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 70.9 bits (172), Expect = 3e-12 Identities = 54/159 (33%), Positives = 83/159 (52%), Gaps = 5/159 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G ++++ E+MENG + S L +D Q + I G A G+ YL S Sbjct: 675 GVVTRSRPVMILTEFMENGALDSFLRMNDG-QFTVIQLVGILRGIASGMKYL---SEMNY 730 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S K + PE ++ Sbjct: 731 VHRDLAARNILVNSNLVCKVSDFGLSRFLENSRSDPTYTSALGGKIPIRWTAPEAISYRK 790 Query: 501 LTEKSDVYSFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 T SDV+S+G+VM EV+ RP D S ++++N E Sbjct: 791 FTSASDVWSYGIVMWEVMSYGERPYWDMS-NQDVINAIE 828
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/177 (26%), Positives = 84/177 (47%), Gaps = 15/177 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNW--------------KQRLEICIGA 284 +G C + + ++ EY G ++ +L P + + K + Sbjct: 553 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQL 612 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL +++ IHRD+ + N+L+ EN + K+ADFGL++ +D +T + Sbjct: 613 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 669 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 ++ PE + T +SDV+SFGV+M E+ P +P E+ L + G + K Sbjct: 670 KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 726
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/139 (33%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V E+MENG + + L D Q + + G A G+ YL + +HRD+ + Sbjct: 707 VMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYL---ADMGYVHRDLAAR 762 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE + ++ T SDV+S+ Sbjct: 763 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 823 GIVMWEVMSYGERPYWDMS 841
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/139 (33%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V E+MENG + + L D Q + + G A G+ YL + +HRD+ + Sbjct: 707 VMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYL---ADMGYVHRDLAAR 762 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE + ++ T SDV+S+ Sbjct: 763 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 823 GIVMWEVMSYGERPYWDMS 841
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/139 (33%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V E+MENG + + L D Q + + G A G+ YL + +HRD+ + Sbjct: 707 VMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYL---ADMGYVHRDLAAR 762 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE + ++ T SDV+S+ Sbjct: 763 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 823 GIVMWEVMSYGERPYWDMS 841
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 343 IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMN---YVHRDLRAANI 399 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 400 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 458 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 459 LTELTTKGRVPYPGMVNREVLDQVERGYR 487
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 70.9 bits (172), Expect = 3e-12 Identities = 50/186 (26%), Positives = 82/186 (44%), Gaps = 16/186 (8%) Frame = +3 Query: 42 VAVKRGNPKSQQGLN-EFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKS 218 VAVK L +F E E G C E ++ ++++E+MENG + Sbjct: 535 VAVKTLKGSCSDSLKRDFEREAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNK 594 Query: 219 HL---------------YGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +L SD L +Q ++I + A + YL + + +HRD+ + Sbjct: 595 YLRMHGPDAAFLKDRDSMDSDEGQLTREQLMKIVLQIASAMEYL---ALQHFVHRDLATR 651 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 N L+ +L+ K+ DFG+S+ D V ++ PE + T +SDV+SFG Sbjct: 652 NCLVGCDLVVKLGDFGMSRDVYTTDYYRVEGTAMLPVRWMPPESIIYRTFTTESDVWSFG 711 Query: 534 VVMLEV 551 V + EV Sbjct: 712 VTLWEV 717
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/135 (31%), Positives = 70/135 (51%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C + ++ EY +G + L + + ++ G A G++YLH I Sbjct: 221 GVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHK---I 275 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 IHRD+KS N+L+ K++DFG SK EL + G+ ++ PE R + ++E Sbjct: 276 IHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTKMSFAGTVAWMAPEVIRNEPVSE 332 Query: 510 KSDVYSFGVVMLEVL 554 K D++SFGVV+ E+L Sbjct: 333 KVDIWSFGVVLWELL 347
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 451 LTELTTKGRVPYPGMVNREVLDQVERGYR 479
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 70.5 bits (171), Expect = 4e-12 Identities = 53/159 (33%), Positives = 85/159 (53%), Gaps = 5/159 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + ++++ E+MENG + S L +D Q + + G A G+ YL S Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---SEMNY 740 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S+ K + PE ++ Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 501 LTEKSDVYSFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 T SDV+S+G+VM EV+ RP D S ++++N E Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMS-NQDVINAIE 838
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 70.5 bits (171), Expect = 4e-12 Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ S L D Q + + G A G+ YL S Sbjct: 688 GVVTKSKPVMIVTEYMENGSLDSFLRKHD-AQFTVIQLVGMLRGIASGMKYL---SDMGY 743 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 744 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPEATAYRKFT 803 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+V+ EV+ Sbjct: 804 SASDVWSYGIVLWEVM 819
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 70.5 bits (171), Expect = 4e-12 Identities = 43/129 (33%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1154 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1208 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1209 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1268 Query: 528 FGVVMLEVL 554 FGVV+ E++ Sbjct: 1269 FGVVLWELM 1277
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/154 (31%), Positives = 81/154 (52%), Gaps = 1/154 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V E+M G++ L D L Q +++ A G+ Y+ + IHRD+++ANI Sbjct: 338 IVTEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIERMN---YIHRDLRAANI 394 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ +NL+ K+ADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 395 LVGDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGIL 453 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMKWQKRG 638 + E++ V P + RE++ E G + Q G Sbjct: 454 LTELVTKGRVPYPGMNNREVLEQVERGYRMQCPG 487
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 338 IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDRMN---YVHRDLRAANI 394 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 395 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 453 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 454 LTELTTKGRVPYPGMVNREVLDQVERGYR 482
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 70.5 bits (171), Expect = 4e-12 Identities = 51/187 (27%), Positives = 86/187 (45%), Gaps = 3/187 (1%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMIL 182 G R D V V + + + + F+ E++ +G+ R + Sbjct: 322 GTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMT-RPGFAI 380 Query: 183 VYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANIL 362 + ++ E ++ HL+ +D + Q +++ A+G+ YLH AK IIHRD+KS NI Sbjct: 381 ITQWCEGSSLYHHLHVADT-RFDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIF 436 Query: 363 LDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFG 533 L E L K+ DFGL+ GS ++ E R Q + +SDVY++G Sbjct: 437 LHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYG 496 Query: 534 VVMLEVL 554 VV+ E++ Sbjct: 497 VVLYELM 503
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 70.5 bits (171), Expect = 4e-12 Identities = 54/176 (30%), Positives = 94/176 (53%), Gaps = 5/176 (2%) Frame = +3 Query: 42 VAVKRGNPK---SQQGLNEFRTEIEXXXXXXXXXXXXXIGYC-DERNEMILVYEYMENGT 209 VA+KR S+ ++ F E+ +G C ++ ++ +V +Y+ G+ Sbjct: 588 VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGS 647 Query: 210 VKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 + S L+ L+ + +L I + A+G+ YLH + IIHRD+ S NILL E+ A V Sbjct: 648 LFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYEDGHAVV 705 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRR-QQLTEKSDVYSFGVVMLEVL 554 ADFG S+ LD+ ++ T G+ ++ PE F + + T K+DV+S+ + + E+L Sbjct: 706 ADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEIL 760
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 451 LTELTTKGRVPYPGMVNREVLDQVERGYR 479
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 70.5 bits (171), Expect = 4e-12 Identities = 44/128 (34%), Positives = 72/128 (56%), Gaps = 1/128 (0%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V EYMENG++ S L D Q + + G A G+ YL S +HRD+ + Sbjct: 746 VMIVVEYMENGSLDSFLRKHDG-HFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAAR 801 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE ++ + SD +S+ Sbjct: 802 NILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSY 861 Query: 531 GVVMLEVL 554 G+VM EV+ Sbjct: 862 GIVMWEVM 869
>EPHA6_HUMAN (Q9UF33) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 70.5 bits (171), Expect = 4e-12 Identities = 44/128 (34%), Positives = 72/128 (56%), Gaps = 1/128 (0%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V EYMENG++ S L D Q + + G A G+ YL S +HRD+ + Sbjct: 746 VMIVVEYMENGSLDSFLRKHDG-HFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAAR 801 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFGLS+ + + + +T K + PE ++ + SD +S+ Sbjct: 802 NILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSY 861 Query: 531 GVVMLEVL 554 G+VM EV+ Sbjct: 862 GIVMWEVM 869
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 451 LTELTTKGRVPYPGMVNREVLDQVERGYR 479
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 451 LTELTTKGRVPYPGMVNREVLDQVERGYR 479
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 70.5 bits (171), Expect = 4e-12 Identities = 50/135 (37%), Positives = 79/135 (58%), Gaps = 10/135 (7%) Frame = +3 Query: 189 EYMENGTVKSHL--YGSDNPSL--NW-KQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 EY+ G+V L YGS +L N+ KQ L +GL YLH+ + I+HRD+K A Sbjct: 477 EYVPGGSVAGLLTMYGSFEETLVKNFIKQTL-------KGLEYLHS---RGIVHRDIKGA 526 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVST-----AVKGSFGYLDPEYFRRQQLTEKSD 518 NIL+D K++DFG+SK EL+ T T + +GS ++ PE ++ TEK+D Sbjct: 527 NILVDNKGKIKISDFGISKK-LELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTD 585 Query: 519 VYSFGVVMLEVLCAR 563 ++S G +++E+L ++ Sbjct: 586 IWSLGCLVIEMLTSK 600
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 70.5 bits (171), Expect = 4e-12 Identities = 44/127 (34%), Positives = 71/127 (55%), Gaps = 1/127 (0%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 ++V EYMENG++ S L D Q + + G A G+ YL S +HRD+ + N Sbjct: 696 MIVTEYMENGSLDSFLRKHD-AQFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAARN 751 Query: 357 ILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 IL++ NL+ KV+DFGLS+ + + + + K + PE ++ T SDV+S+G Sbjct: 752 ILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAMSYRKFTSASDVWSYG 811 Query: 534 VVMLEVL 554 +V+ EV+ Sbjct: 812 IVLWEVM 818
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 70.1 bits (170), Expect = 5e-12 Identities = 44/136 (32%), Positives = 73/136 (53%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ S L D Q + + G A G+ YL S Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHD-AQFTVIQLVGMLRGIASGMKYL---SDMGY 742 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 743 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFT 802 Query: 507 EKSDVYSFGVVMLEVL 554 SD +S+G+V+ EV+ Sbjct: 803 SASDAWSYGIVLWEVM 818
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 70.1 bits (170), Expect = 5e-12 Identities = 53/165 (32%), Positives = 82/165 (49%), Gaps = 15/165 (9%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 IG + + + EY++ GT++ + D+ W QR+ A G+ YLH+ + Sbjct: 400 IGVLYKDKRLNFITEYIKGGTLRGIIKNMDS-QYPWSQRVSFAKDIASGMAYLHSMN--- 455 Query: 327 IIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVST--------------AVKGSF 464 IIHRD+ S N L+ EN VADFGL++ +D+ + S V G+ Sbjct: 456 IIHRDLNSHNCLVRENRNVVVADFGLARL--MIDEKNQSEDLRSLKKPDRKKRYTVVGNP 513 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPS-LPREM 596 ++ PE + EK DV+SFG+V+ E++ R DP LPR M Sbjct: 514 YWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYLPRTM 557
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 70.1 bits (170), Expect = 5e-12 Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 1/156 (0%) Frame = +3 Query: 159 DERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHR 338 +E+ + +V EYM G++ +L L L+ + + YL + +HR Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN---FVHR 313 Query: 339 DVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSD 518 D+ + N+L+ E+ +AKV+DFGL+K T K + PE R ++ + KSD Sbjct: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSD 368 Query: 519 VYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMK 623 V+SFG+++ E+ V P +P +++V E G K Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 70.1 bits (170), Expect = 5e-12 Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 1/156 (0%) Frame = +3 Query: 159 DERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHR 338 +E+ + +V EYM G++ +L L L+ + + YL + +HR Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN---FVHR 313 Query: 339 DVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSD 518 D+ + N+L+ E+ +AKV+DFGL+K T K + PE R ++ + KSD Sbjct: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSD 368 Query: 519 VYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMK 623 V+SFG+++ E+ V P +P +++V E G K Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 334 IVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 390 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 391 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 449 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 450 LTELTTKGRVPYPGMVNREVLDQVERGYR 478
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/130 (33%), Positives = 70/130 (53%), Gaps = 1/130 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EY++ T++ + N +L+ + ++ +G L Y H IIHRD+K NI Sbjct: 98 IVMEYVKGQTLRDII--KVNGALSQRDCEQVMLGVLNALDYSHR---MGIIHRDIKPGNI 152 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHV-STAVKGSFGYLDPEYFRRQQLTEKSDVYSFGV 536 ++ E + KV DFG+++ + T S V G+ YL PE R + + +SD+YS G Sbjct: 153 MISEQGVVKVMDFGIARALDDSAATMTQSQGVVGTAQYLSPEQARGETVDMRSDLYSAGC 212 Query: 537 VMLEVLCARP 566 V+ E+L RP Sbjct: 213 VLYEMLTGRP 222
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 70.1 bits (170), Expect = 5e-12 Identities = 50/151 (33%), Positives = 78/151 (51%), Gaps = 7/151 (4%) Frame = +3 Query: 147 IGYCDERNEM-ILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAK 323 +G C R+ + ++V YM +G ++ H + S K+ + + A G+ YL + K Sbjct: 125 LGVCLPRHGLPLVVLPYMRHGDLR-HFVRAQERSPTVKELIGFGLQVALGMEYL---AQK 180 Query: 324 AIIHRDVKSANILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQ 497 +HRD+ + N +LDE L KVADFGL++ G E K ++ E + Q Sbjct: 181 KFVHRDLAARNCMLDETLTVKVADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESLQTQ 240 Query: 498 QLTEKSDVYSFGVVMLEVL----CARPVIDP 578 + T KSDV+SFGV+M E+L P +DP Sbjct: 241 KFTTKSDVWSFGVLMWELLTRGASPYPEVDP 271
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 70.1 bits (170), Expect = 5e-12 Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 19/200 (9%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLE 269 F TE++ IG + ++ L+ EY+E GT+K L D W+Q++ Sbjct: 373 FLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVD--PFPWQQKVR 430 Query: 270 ICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS------KTGPELDQ 431 G A G+ YLH+ IIHRD+ S N L+ + VADFGLS + P +++ Sbjct: 431 FAKGIASGMAYLHS---MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEK 487 Query: 432 THVST------------AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 V G+ ++ PE + E DV+SFG+V+ E++ + D Sbjct: 488 AATKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII-GQVYAD 546 Query: 576 PS-LPREMVNLAEWGMKWQK 632 P LPR + + W+K Sbjct: 547 PDCLPRTLDFGLNVKLFWEK 566
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 70.1 bits (170), Expect = 5e-12 Identities = 60/200 (30%), Positives = 90/200 (45%), Gaps = 19/200 (9%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLE 269 F TE++ IG + ++ L+ EY+E GT+K L D W+Q++ Sbjct: 373 FLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD--PFPWQQKVR 430 Query: 270 ICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS-------KTGP-EL 425 G A G+ YLH+ IIHRD+ S N L+ + VADFGLS K P E Sbjct: 431 FAKGIASGMAYLHS---MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEK 487 Query: 426 DQTHVST----------AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 T T V G+ ++ PE + E D++SFG+V+ E++ + D Sbjct: 488 ATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYAD 546 Query: 576 PS-LPREMVNLAEWGMKWQK 632 P LPR + + W+K Sbjct: 547 PDCLPRTLDFGLNVKLFWEK 566
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 70.1 bits (170), Expect = 5e-12 Identities = 44/136 (32%), Positives = 75/136 (55%), Gaps = 1/136 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V EYMENG++ + L +D Q + + G + G+ YL S Sbjct: 741 GVVTKSKPVMIVTEYMENGSLDTFLKKNDG-QFTVIQLVGMLRGISAGMKYL---SDMGY 796 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 +HRD+ + NIL++ NL+ KV+DFGLS+ + + + + K + PE ++ T Sbjct: 797 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFT 856 Query: 507 EKSDVYSFGVVMLEVL 554 SDV+S+G+VM EV+ Sbjct: 857 SASDVWSYGIVMWEVV 872
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 70.1 bits (170), Expect = 5e-12 Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 28/203 (13%) Frame = +3 Query: 27 RDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENG 206 +D VAVK + +F+ E E G C + + +I+V+EYM++G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 207 TVKSHL--YGSD------------NPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 + L +G D L Q L I A G+ YL +++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 345 KSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF--------------GYLDPE 482 + N L+ NLL K+ DFG+S+ D + F ++ PE Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 740 Query: 483 YFRRQQLTEKSDVYSFGVVMLEV 551 ++ T +SDV+SFGV++ E+ Sbjct: 741 SIMYRKFTTESDVWSFGVILWEI 763
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 70.1 bits (170), Expect = 5e-12 Identities = 47/178 (26%), Positives = 82/178 (46%) Frame = +3 Query: 33 DTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTV 212 D VA+K ++ + LN+ EI G+ + E+ ++ EY NG++ Sbjct: 48 DQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSL 107 Query: 213 KSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVA 392 + L + L+ + GL YLH + +IHRD+K+ANILL + K+A Sbjct: 108 R-RLISRSSTGLSENESKTYVTQTLLGLKYLH---GEGVIHRDIKAANILLSADNTVKLA 163 Query: 393 DFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARP 566 DFG+S + + G+ ++ PE + + SD++S G ++E+L P Sbjct: 164 DFGVSTI-----VNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNP 216
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 70.1 bits (170), Expect = 5e-12 Identities = 58/205 (28%), Positives = 96/205 (46%), Gaps = 6/205 (2%) Frame = +3 Query: 3 GKSTRXALRDDTKVAVKRGNPKSQQGLN-EFRTEIEXXXXXXXXXXXXXIGYCDERNEMI 179 G+ + L+D T VAVK Q L +F E + IG C +R + Sbjct: 575 GEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVY 634 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 ++ E + G + L + L KQ ++ + AA G+ YL + K IHRD+ + N Sbjct: 635 IIMELVSGGDFLTFLRRKKD-ELKLKQLVKFSLDAAAGMLYLES---KNCIHRDLAARNC 690 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKG-SFGYLDPEYFRRQQLTEKSDVYSFGV 536 L+ EN + K++DFG+S+ E + S+ +K + PE + + +SDV+SFG+ Sbjct: 691 LVGENNVLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGI 748 Query: 537 VMLEV----LCARPVIDPSLPREMV 599 ++ E +C P + RE V Sbjct: 749 LLWETFSLGVCPYPGMTNQQAREQV 773
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 69.7 bits (169), Expect = 7e-12 Identities = 41/127 (32%), Positives = 72/127 (56%), Gaps = 1/127 (0%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + +V E++ G + + L ++ Q L+ + A G+ YL + K ++HRD+ + Sbjct: 298 LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAAR 354 Query: 354 NILLDENLLAKVADFGLSKTGPE-LDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL+ E+L+AKV+DFGL+K + LD + + + PE + + + KSDV+SF Sbjct: 355 NILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK------WTAPEALKNGRFSSKSDVWSF 408 Query: 531 GVVMLEV 551 GV++ EV Sbjct: 409 GVLLWEV 415
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 69.7 bits (169), Expect = 7e-12 Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 13/163 (7%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 IG + + + EY++ GT++ + D+ W QR+ A G+ YLH+ + Sbjct: 400 IGVLYKDKRLNFITEYIKGGTLRGIIKSMDS-QYPWSQRVSFAKDIASGMAYLHSMN--- 455 Query: 327 IIHRDVKSANILLDENLLAKVADFGLSK-----TGPELDQTHVST-------AVKGSFGY 470 IIHRD+ S N L+ EN VADFGL++ G D + V G+ + Sbjct: 456 IIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYW 515 Query: 471 LDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPS-LPREM 596 + PE + EK DV+SFG+V+ E++ R DP LPR M Sbjct: 516 MAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYLPRTM 557
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 69.7 bits (169), Expect = 7e-12 Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 1/156 (0%) Frame = +3 Query: 159 DERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHR 338 +E+ + +V EYM G++ +L L L+ + + YL + +HR Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVLEAMEYLEGNN---FVHR 313 Query: 339 DVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSD 518 D+ + N+L+ E+ +AKV+DFGL+K T K + PE R ++ + KSD Sbjct: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSD 368 Query: 519 VYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMK 623 V+SFG+++ E+ V P +P +++V E G K Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 69.7 bits (169), Expect = 7e-12 Identities = 53/161 (32%), Positives = 79/161 (49%), Gaps = 13/161 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 IG + + + EY++ GT++ + D+ W QR+ A G+ YLH+ + Sbjct: 407 IGVLYKEKRLNFITEYIKGGTLRGLIKSMDS-HYPWSQRVSFAKDIAAGMAYLHSMN--- 462 Query: 327 IIHRDVKSANILLDENLLAKVADFGLS------KTGPELDQT------HVSTAVKGSFGY 470 IIHRD+ S N L+ EN VADFGL+ K PE Q V G+ + Sbjct: 463 IIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKNQPEHLQNLKKPDRKKRYTVVGNPYW 522 Query: 471 LDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPS-LPR 590 + PE + EK D++SFG+V+ E++ R DP LPR Sbjct: 523 MAPEMINGRSYDEKVDIFSFGIVLCEII-GRVSADPDYLPR 562
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 69.7 bits (169), Expect = 7e-12 Identities = 37/93 (39%), Positives = 58/93 (62%) Frame = +3 Query: 276 IGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVK 455 +G A G++YLH IIHRD+KS N+L+ + + K++DFG SK EL + Sbjct: 218 MGIAGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFA 271 Query: 456 GSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 G+ ++ PE R + ++EK D++SFGVV+ E+L Sbjct: 272 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 304
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/149 (30%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L + +L +++ A G+ Y+ + IHRD++SANI Sbjct: 339 IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN---YIHRDLRSANI 395 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ +NL+ K+ADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 396 LVGDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 454 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E++ V P + RE++ E G + Sbjct: 455 LTELVTKGRVPYPGMNNREVLEQVERGYR 483
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 69.7 bits (169), Expect = 7e-12 Identities = 52/151 (34%), Positives = 85/151 (56%), Gaps = 5/151 (3%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ E+MENG + S L +D Q + + G A G+ YL + + +HRD+ + Sbjct: 689 VMILTEFMENGALDSFLRLNDG-QFTVIQLVGMLRGIASGMRYL---AEMSYVHRDLAAR 744 Query: 354 NILLDENLLAKVADFGLSKTGPE--LDQTHVST-AVKGSFGYLDPEYFRRQQLTEKSDVY 524 NIL++ NL+ KV+DFGLS+ E D T+ S+ K S + PE ++ T SD + Sbjct: 745 NILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAIAFRKFTSASDAW 804 Query: 525 SFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 S+G+VM EV+ RP D S ++++N E Sbjct: 805 SYGIVMWEVMSFGERPYWDMS-NQDVINAIE 834
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/139 (33%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ EYMENG++ + L +D Q + I G G+ YL S + +HRD+ + Sbjct: 694 VMIITEYMENGSLDAFLRKNDG-RFTVIQLVGILRGIGSGMKYL---SDMSYVHRDLAAR 749 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFG+S+ + + + + K + PE ++ T SDV+S+ Sbjct: 750 NILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSY 809 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 810 GIVMWEVMSYGERPYWDMS 828
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 69.7 bits (169), Expect = 7e-12 Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 8/152 (5%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + +++V E+MENG++ S L + + Q + + G A G+ YL S Sbjct: 703 GVVTKSRPVMIVTEFMENGSLDSFLRQKEG-QFSVLQLVGMLRGIAAGMRYL---SDMNY 758 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFG------YLDPEYFR 491 +HRD+ + NIL++ NL+ KV+DFGLS+ L+ + G+ G + PE + Sbjct: 759 VHRDLAARNILVNSNLVCKVSDFGLSRF---LEDDASNPTYTGALGCKIPIRWTAPEAVQ 815 Query: 492 RQQLTEKSDVYSFGVVMLEVLC--ARPVIDPS 581 ++ T SDV+S+G+VM EV+ RP D S Sbjct: 816 YRKFTSSSDVWSYGIVMWEVMSYGERPYWDMS 847
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 69.7 bits (169), Expect = 7e-12 Identities = 37/93 (39%), Positives = 58/93 (62%) Frame = +3 Query: 276 IGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVK 455 +G A G++YLH IIHRD+KS N+L+ + + K++DFG SK EL + Sbjct: 251 MGIAGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFA 304 Query: 456 GSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 G+ ++ PE R + ++EK D++SFGVV+ E+L Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 337
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 69.7 bits (169), Expect = 7e-12 Identities = 37/93 (39%), Positives = 58/93 (62%) Frame = +3 Query: 276 IGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVK 455 +G A G++YLH IIHRD+KS N+L+ + + K++DFG SK EL + Sbjct: 251 MGIAGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFA 304 Query: 456 GSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 G+ ++ PE R + ++EK D++SFGVV+ E+L Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 337
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/145 (32%), Positives = 77/145 (53%), Gaps = 1/145 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSL-PREMVNLAE 611 + E+ V P + RE+++ E Sbjct: 451 LTELTTKGRVPYPGMVNREVLDQVE 475
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 69.3 bits (168), Expect = 9e-12 Identities = 52/159 (32%), Positives = 85/159 (53%), Gaps = 5/159 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + ++++ E+MENG + S L +D Q + + G A G+ YL + Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---AEMNY 740 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S+ K + PE ++ Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 501 LTEKSDVYSFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 T SDV+S+G+VM EV+ RP D S ++++N E Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMS-NQDVINAIE 838
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 69.3 bits (168), Expect = 9e-12 Identities = 52/159 (32%), Positives = 85/159 (53%), Gaps = 5/159 (3%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + ++++ E+MENG + S L +D Q + + G A G+ YL + Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---AEMNY 740 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S+ K + PE ++ Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 501 LTEKSDVYSFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 T SDV+S+G+VM EV+ RP D S ++++N E Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMS-NQDVINAIE 838
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 3/172 (1%) Frame = +3 Query: 48 VKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLY 227 +K P ++Q F+ E++ +G+ R ++ ++ E ++ HL+ Sbjct: 336 LKVAQPTAEQA-QAFKNEMQVLRKTRHVNILLFMGFMT-RPGFAIITQWCEGSSLYHHLH 393 Query: 228 GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS 407 +D + Q +++ A+G+ YLH AK IIHRD+KS NI L E L K+ DFGL+ Sbjct: 394 VADT-RFDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFGLA 449 Query: 408 KTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 GS ++ E R Q + +SDVY++GVV+ E++ Sbjct: 450 TVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 501
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 3/172 (1%) Frame = +3 Query: 48 VKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLY 227 +K P ++Q F+ E++ +G+ R ++ ++ E ++ HL+ Sbjct: 336 LKVAQPTAEQA-QAFKNEMQVLRKTRHVNILLFMGFMT-RPGFAIITQWCEGSSLYHHLH 393 Query: 228 GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS 407 +D + Q +++ A+G+ YLH AK IIHRD+KS NI L E L K+ DFGL+ Sbjct: 394 VADT-RFDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFGLA 449 Query: 408 KTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 GS ++ E R Q + +SDVY++GVV+ E++ Sbjct: 450 TVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 501
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 69.3 bits (168), Expect = 9e-12 Identities = 43/129 (33%), Positives = 71/129 (55%), Gaps = 4/129 (3%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V E+M +G+++ L SL W +L I + +++LH+ ++H D+K NI Sbjct: 108 IVMEFMASGSLEKTL---PTHSLCWPLKLRIIHETSLAMNFLHS-IKPPLLHLDLKPGNI 163 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHV--STAVKGSFGYLDPEYFRRQQLT--EKSDVYS 527 LLD N+ K++DFGLSK + Q +A++G+ Y+ PE F + DVYS Sbjct: 164 LLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDVYS 223 Query: 528 FGVVMLEVL 554 F +V+ E+L Sbjct: 224 FAIVIWEIL 232
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 69.3 bits (168), Expect = 9e-12 Identities = 42/129 (32%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1152 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1206 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1207 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1266 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1267 FGVLLWELM 1275
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 69.3 bits (168), Expect = 9e-12 Identities = 42/129 (32%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1154 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1208 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1209 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1268 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1269 FGVLLWELM 1277
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 69.3 bits (168), Expect = 9e-12 Identities = 42/129 (32%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1154 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1208 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1209 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1268 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1269 FGVLLWELM 1277
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 69.3 bits (168), Expect = 9e-12 Identities = 42/129 (32%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1154 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1208 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1209 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1268 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1269 FGVLLWELM 1277
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 69.3 bits (168), Expect = 9e-12 Identities = 42/129 (32%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1154 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1208 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1209 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1268 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1269 FGVLLWELM 1277
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 69.3 bits (168), Expect = 9e-12 Identities = 45/138 (32%), Positives = 76/138 (55%), Gaps = 10/138 (7%) Frame = +3 Query: 171 EMILVYEYMENGTVKSHLYGSDNPSL--NWKQRLEICIGAARGLHYLHTGSAKAIIHRDV 344 ++ LV EY G++ L G P + NW I ARG++YLH + +IIHRD+ Sbjct: 212 KLCLVMEYARGGSLNRILAGKIPPDVLVNW------AIQIARGMNYLHNEAPMSIIHRDL 265 Query: 345 KSANILLDENL--------LAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ 500 KS+N+L+ E + K+ DFGL++ E+ T +A G++ ++ PE Sbjct: 266 KSSNVLIYEAIEGNHLQQKTLKITDFGLAR---EMYNTQRMSAA-GTYAWMPPEVISVST 321 Query: 501 LTEKSDVYSFGVVMLEVL 554 ++ SDV+S+GV++ E++ Sbjct: 322 YSKFSDVWSYGVLLWELI 339
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 69.3 bits (168), Expect = 9e-12 Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 7/183 (3%) Frame = +3 Query: 24 LRDDTK--VAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDE--RNEMILVYE 191 L+D+T VAVK+ +++ L +F EIE G C R + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIME 930 Query: 192 YMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDE 371 Y+ G+++ +L ++ + L+ +G+ YL T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 372 NLLAKVADFGLSKTGPELDQTHVSTAVKGS---FGYLDPEYFRRQQLTEKSDVYSFGVVM 542 K+ DFGL+K P+ D+ + G F Y PE + + SDV+SFGVV+ Sbjct: 987 ENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYA-PESLTESKFSVASDVWSFGVVL 1044 Query: 543 LEV 551 E+ Sbjct: 1045 YEL 1047 Score = 35.8 bits (81), Expect = 0.11 Identities = 38/143 (26%), Positives = 70/143 (48%), Gaps = 9/143 (6%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C +E ILV E+++ G++ ++L + N +N +LE+ A +H+L + + Sbjct: 614 GVCVCGDENILVQEFVKFGSLDTYLKKNKN-CINILWKLEVAKQLAWAMHFLEENT---L 669 Query: 330 IHRDVKSANILL--DENL------LAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 485 IH +V + NILL +E+ K++D G+S T D ++ ++ PE Sbjct: 670 IHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD------ILQERIPWVPPEC 723 Query: 486 FRR-QQLTEKSDVYSFGVVMLEV 551 + L +D +SFG + E+ Sbjct: 724 IENPKNLNLATDKWSFGTTLWEI 746
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 69.3 bits (168), Expect = 9e-12 Identities = 53/170 (31%), Positives = 85/170 (50%), Gaps = 5/170 (2%) Frame = +3 Query: 150 GYCDERNE--MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAK 323 G C+++ E + LV EY+ G+++ +L S+ Q L G+ YLH A+ Sbjct: 964 GCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQICEGMAYLH---AQ 1017 Query: 324 AIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTH-VSTAVKGSFGYLDPEYFRRQQ 500 IHRD+ + N+LLD + L K+ DFGL+K PE + + V + PE + + Sbjct: 1018 HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 1077 Query: 501 LTEKSDVYSFGVVMLEVL--CARPVIDPSLPREMVNLAEWGMKWQKRGEL 644 SDV+SFGV + E+L C P+ E++ +A+ M + EL Sbjct: 1078 FYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 1127 Score = 30.0 bits (66), Expect = 6.2 Identities = 36/138 (26%), Positives = 58/138 (42%), Gaps = 4/138 (2%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGS-DNPSLNWKQRLEICIGAARGLHYLHTGSAKA 326 G C E I+V EY+E+G + L + + WK + + A L YL K Sbjct: 675 GVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWK--MVVAQQLASALSYLEN---KN 729 Query: 327 IIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVK-GSFGYLDPEYF--RRQ 497 ++H +V NILL LA+ + + P + +S + +L PE Sbjct: 730 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGAN 789 Query: 498 QLTEKSDVYSFGVVMLEV 551 L+ D + FG +LE+ Sbjct: 790 SLSTAMDKWGFGATLLEI 807
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 69.3 bits (168), Expect = 9e-12 Identities = 42/129 (32%), Positives = 74/129 (57%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL ++K +HRD+ + Sbjct: 1155 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---ASKKFVHRDLAAR 1209 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1210 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1269 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1270 FGVLLWELM 1278
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 3/172 (1%) Frame = +3 Query: 48 VKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLY 227 +K P ++Q F+ E++ +G+ R ++ ++ E ++ HL+ Sbjct: 338 LKVAQPTAEQA-QAFKNEMQVLRKTRHVNILLFMGFMT-RPGFAIITQWCEGSSLYHHLH 395 Query: 228 GSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS 407 +D + Q +++ A+G+ YLH AK IIHRD+KS NI L E L K+ DFGL+ Sbjct: 396 VADT-RFDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFGLA 451 Query: 408 KTGPELDQTHVSTAVKGSFGYLDPEYFRRQQ---LTEKSDVYSFGVVMLEVL 554 GS ++ E R Q + +SDVY++GVV+ E++ Sbjct: 452 TVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 503
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/136 (30%), Positives = 70/136 (51%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EY++ T+K + + P L K+ +EI R L + H IIHRD+K NI Sbjct: 85 IVMEYVKGRTLKELIRENGGP-LEVKRAVEIASQVCRALDHAHKNK---IIHRDIKPQNI 140 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ + + KV DFG+++ T+ + G+ Y PE + + E++D+YS G+V Sbjct: 141 LVTDEDVVKVTDFGIARAANGATITYTGDVI-GTAYYFSPEQAKGSIVDERTDIYSLGIV 199 Query: 540 MLEVLCARPVIDPSLP 587 + E+L + + P Sbjct: 200 LFEMLTGKVPFEGDSP 215
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 69.3 bits (168), Expect = 9e-12 Identities = 55/187 (29%), Positives = 85/187 (45%), Gaps = 5/187 (2%) Frame = +3 Query: 21 ALRDDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYME 200 AL+ K + GN + Q FR E+E G+ +++ + L+ EY+ Sbjct: 126 ALKCMEKKELVEGNVEKQ-----FRREVEIQSNLRHTNVLRLFGHFHDKDRVYLILEYVV 180 Query: 201 NGTVKSHLYGSDNPSLNWKQRLEICIGA-----ARGLHYLHTGSAKAIIHRDVKSANILL 365 +G + L N K+ E + + L YLH K IIHRD+K NILL Sbjct: 181 HGELYKLLR-------NQKRFTESTASSYIYQMSEALLYLH---GKNIIHRDIKPENILL 230 Query: 366 DENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVML 545 N K++DFG S P ++ + + G+ YL PE + + + DV+S G++M Sbjct: 231 HFNDTIKISDFGWSVHAP----SNRRSTLCGTMDYLPPEIVQSRPYDKNVDVWSLGILMY 286 Query: 546 EVLCARP 566 E LC P Sbjct: 287 EFLCGAP 293
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 69.3 bits (168), Expect = 9e-12 Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 8/186 (4%) Frame = +3 Query: 30 DDTKVAVKRGNPK---SQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEM-----ILV 185 +D +VAVK P+ + + L+ FR E Y + + +V Sbjct: 42 NDREVAVKVLRPEFSDNTEFLSRFRNEARAAENIHSEHVVTTYDYREVADPAGHTFCFIV 101 Query: 186 YEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILL 365 EY+ ++ L +L + L++ AA GL +H ++HRD+K N+L+ Sbjct: 102 LEYIRGESLADML--EREGALPEELALDVMEQAAHGLSVIHR---MGLVHRDIKPGNMLI 156 Query: 366 DENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVML 545 N + K+ DFG++K + T V G+ Y+ PE + Q+T SDVYS GVV Sbjct: 157 TANGILKITDFGIAKAAASVPLTRTGMVV-GTAQYVSPEQAQGHQVTPASDVYSLGVVGY 215 Query: 546 EVLCAR 563 E+L R Sbjct: 216 EMLSGR 221
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V E+M G++ L D L Q +++ A G+ Y+ + IHRD+++ANI Sbjct: 343 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMN---YIHRDLRAANI 399 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ K+ADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 400 LVGENLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 458 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 E++ V P + RE++ E G + Sbjct: 459 QTELVTKGRVPYPGMVNREVLEQVERGYR 487
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 69.3 bits (168), Expect = 9e-12 Identities = 46/149 (30%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L + +L +++ ARG+ Y+ + IHRD++SANI Sbjct: 339 IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERMN---YIHRDLRSANI 395 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ L+ K+ADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 396 LVGNGLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 454 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E++ V P + RE++ E G + Sbjct: 455 LTELVTKGRVPYPGMNNREVLEQVERGYR 483
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 69.3 bits (168), Expect = 9e-12 Identities = 46/138 (33%), Positives = 77/138 (55%), Gaps = 3/138 (2%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + + ++++ E+MENG++ S L +D Q + + G A G+ YL + Sbjct: 705 GVVTKSSPVMIITEFMENGSLDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---ADMNY 760 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S K + PE + ++ Sbjct: 761 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK 820 Query: 501 LTEKSDVYSFGVVMLEVL 554 T SDV+S+G+VM EV+ Sbjct: 821 FTSASDVWSYGIVMWEVM 838
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/126 (32%), Positives = 69/126 (54%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 + +V E++ G + + L ++ Q L+ + A G+ YL + K ++HRD+ + Sbjct: 259 LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAAR 315 Query: 354 NILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 NIL+ E+L+AKV+DFGL+K VK + PE + + + KSDV+SFG Sbjct: 316 NILVSEDLVAKVSDFGLAKAELRKGLDSSRLPVK----WTAPEALKNGRFSSKSDVWSFG 371 Query: 534 VVMLEV 551 V++ EV Sbjct: 372 VLLWEV 377
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 68.9 bits (167), Expect = 1e-11 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSLPR-EMVNLAEWGMK 623 + E+ V P + E+++ E G + Sbjct: 451 LTELTTKGRVPYPGMGNGEVLDRVERGYR 479
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) Length = 813 Score = 68.9 bits (167), Expect = 1e-11 Identities = 47/177 (26%), Positives = 86/177 (48%), Gaps = 15/177 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHL---------YGSD-----NPSLNWKQRLEICIGA 284 +G C + + ++ EY G ++ +L Y D + + +K + Sbjct: 541 LGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQI 600 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL +++ IHRD+ + N+L+ EN + K+ADFGL++ +D ++ + Sbjct: 601 ARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPV 657 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 ++ PE + T +SDV+SFGV+M E+ P +P E+ L + G + K Sbjct: 658 KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 714
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 68.9 bits (167), Expect = 1e-11 Identities = 43/134 (32%), Positives = 70/134 (52%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C ++ + +V E+ME G + + L + L +C G+ YL S Sbjct: 429 GVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRDMLLSMCQDVCEGMEYLERNS---F 484 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 IHRD+ + N L++E + KV+DFG+++ + DQ S+ K + PE F + + Sbjct: 485 IHRDLAARNCLVNEAGVVKVSDFGMARYVLD-DQYTSSSGAKFPVKWCPPEVFNYSRFSS 543 Query: 510 KSDVYSFGVVMLEV 551 KSDV+SFGV+M E+ Sbjct: 544 KSDVWSFGVLMWEI 557
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 68.9 bits (167), Expect = 1e-11 Identities = 41/140 (29%), Positives = 73/140 (52%) Frame = +3 Query: 168 NEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 N +V EY+ T+K + +N + + + ++ A+ L++ H I+HRD+K Sbjct: 81 NVNYIVMEYVAGKTLKKLI--KENGKIEFNKIIDYATQIAKALNFAHKNG---IVHRDIK 135 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 NI++ ++ + KV DFG++K E T + V GS YL PE + + ++D+YS Sbjct: 136 PHNIMVTDDDIIKVTDFGIAKASNESTIT-TTNKVVGSAHYLSPEQAQGIPVDCRTDIYS 194 Query: 528 FGVVMLEVLCARPVIDPSLP 587 FG+V+ E+ + D P Sbjct: 195 FGIVLYEMATGKVPYDADTP 214
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 68.9 bits (167), Expect = 1e-11 Identities = 40/125 (32%), Positives = 68/125 (54%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 ++ EYMENG++ L LN + L++ A G+ ++ + IHRD+++ANI Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQN---YIHRDLRAANI 369 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ + L K+ADFGL++ + + T K + PE T KSDV+SFG++ Sbjct: 370 LVSDTLSCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVWSFGIL 428 Query: 540 MLEVL 554 + E++ Sbjct: 429 LTEIV 433
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 68.9 bits (167), Expect = 1e-11 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V E+M G++ L D L Q +++ A G+ Y+ + IHRD+++ANI Sbjct: 345 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMN---YIHRDLRAANI 401 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ K+ADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 402 LVGENLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 460 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 E++ V P + RE++ E G + Sbjct: 461 QTELVTKGRVPYPGMVNREVLEQVERGYR 489
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 68.9 bits (167), Expect = 1e-11 Identities = 56/200 (28%), Positives = 90/200 (45%), Gaps = 19/200 (9%) Frame = +3 Query: 90 FRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLE 269 F TE++ IG + ++ L+ EY+E GT+K L D W+Q++ Sbjct: 373 FLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVD--PFPWQQKVR 430 Query: 270 ICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLS------KTGPELDQ 431 G + G+ YLH+ IIHRD+ S N L+ + VADFGLS + P +++ Sbjct: 431 FAKGISSGMAYLHS---MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEK 487 Query: 432 THVST------------AVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVID 575 V G+ ++ PE + E DV+SFG+V+ E++ + D Sbjct: 488 ATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII-GQVYAD 546 Query: 576 PS-LPREMVNLAEWGMKWQK 632 P LPR + + W+K Sbjct: 547 PDCLPRTLDFGLNVKLFWEK 566
>GUC2C_PIG (P55204) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) Length = 1073 Score = 68.9 bits (167), Expect = 1e-11 Identities = 38/132 (28%), Positives = 70/132 (53%), Gaps = 5/132 (3%) Frame = +3 Query: 183 VYEYMENGTVKSHLYGS----DNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKS 350 V EY E G+++ L + D ++W+ ++ + A+G+ YLH S+K +H +KS Sbjct: 560 VIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLH--SSKTEVHGRLKS 617 Query: 351 ANILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N ++D ++ K+ DFG + P+ D + PE+ RR +++K DVYS Sbjct: 618 TNCVVDSRMVVKITDFGCNSILAPKKDL------------WTAPEHLRRASVSQKGDVYS 665 Query: 528 FGVVMLEVLCAR 563 +G++ E++ R Sbjct: 666 YGIIAQEIILRR 677
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/138 (33%), Positives = 76/138 (55%), Gaps = 3/138 (2%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + ++++ E+MENG++ S L +D Q + + G A G+ YL + Sbjct: 695 GVVTKSTPVMIITEFMENGSLDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---ADMNY 750 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S K + PE + ++ Sbjct: 751 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK 810 Query: 501 LTEKSDVYSFGVVMLEVL 554 T SDV+S+G+VM EV+ Sbjct: 811 FTSASDVWSYGIVMWEVM 828
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 68.9 bits (167), Expect = 1e-11 Identities = 52/151 (34%), Positives = 83/151 (54%), Gaps = 5/151 (3%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 +++V E+MENG + S L +D Q + + G A G+ YL S +HRD+ + Sbjct: 261 VLIVTEFMENGALDSFLRLNDG-RFTVTQLVGMLRGIAAGMKYL---SDMNYVHRDLAAR 316 Query: 354 NILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQLTEKSDVY 524 N+L++ NL+ KV+DFGLS+ D T+ S+ K + PE ++ T SDV+ Sbjct: 317 NVLVNSNLVCKVSDFGLSRFLDDNSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDVW 376 Query: 525 SFGVVMLEVLC--ARPVIDPSLPREMVNLAE 611 S+G+VM EV+ RP D S ++++N E Sbjct: 377 SYGIVMWEVMSFGERPYWDMS-NQDVMNAVE 406
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/138 (33%), Positives = 76/138 (55%), Gaps = 3/138 (2%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G + ++++ E+MENG++ S L +D Q + + G A G+ YL + Sbjct: 687 GVVTKSTPVMIITEFMENGSLDSFLRQNDG-QFTVIQLVGMLRGIAAGMKYL---ADMNY 742 Query: 330 IHRDVKSANILLDENLLAKVADFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYFRRQQ 500 +HRD+ + NIL++ NL+ KV+DFGLS+ D T+ S K + PE + ++ Sbjct: 743 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK 802 Query: 501 LTEKSDVYSFGVVMLEVL 554 T SDV+S+G+VM EV+ Sbjct: 803 FTSASDVWSYGIVMWEVM 820
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 68.9 bits (167), Expect = 1e-11 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 19/155 (12%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTV-----KSHLYGSDNP---------SLNWKQRLEICIGA 284 +G C+ R + + EY G + KS + +D +L+ +Q L A Sbjct: 902 LGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDA 961 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 A G+ YL S K IHRD+ + N+L+ ENL +K+ADFGLS+ G E+ VK + Sbjct: 962 ANGMQYL---SEKQFIHRDLAARNVLVGENLASKIADFGLSR-GEEV-------YVKKTM 1010 Query: 465 GYLDPEYFRRQQL-----TEKSDVYSFGVVMLEVL 554 G L + + L T KSDV+SFGV++ E++ Sbjct: 1011 GRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIV 1045
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/135 (31%), Positives = 74/135 (54%), Gaps = 1/135 (0%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSL-NWKQRLEICIGAARGLHYLHTGSAKA 326 G C + + +V EYM++G++ ++L + + N L++CI ++G+ YL + Sbjct: 586 GVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN--- 642 Query: 327 IIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLT 506 IHRD+ + N L+ + KVADFGL++ + DQ S K + PE + + Sbjct: 643 YIHRDLAARNCLVGSENVVKVADFGLARYVLD-DQYTSSGGTKFPIKWAPPEVLNYTRFS 701 Query: 507 EKSDVYSFGVVMLEV 551 KSDV+++GV+M E+ Sbjct: 702 SKSDVWAYGVLMWEI 716
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 68.9 bits (167), Expect = 1e-11 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 19/155 (12%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTV-----KSHLYGSDNP---------SLNWKQRLEICIGA 284 +G C+ R + + EY G + KS + +D +L+ +Q L A Sbjct: 900 LGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDA 959 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 A G+ YL S K IHRD+ + N+L+ ENL +K+ADFGLS+ G E+ VK + Sbjct: 960 ANGMQYL---SEKQFIHRDLAARNVLVGENLASKIADFGLSR-GEEV-------YVKKTM 1008 Query: 465 GYLDPEYFRRQQL-----TEKSDVYSFGVVMLEVL 554 G L + + L T KSDV+SFGV++ E++ Sbjct: 1009 GRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIV 1043
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +E+ A G+ Y+ + +HRD+++ANI Sbjct: 332 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERMN---YVHRDLRAANI 388 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T + + PE + T KSDV+SFG++ Sbjct: 389 LVGENLVCKVADFGLARLIEDNEYT-ARPGARFPVKWTAPEAALYGRFTIKSDVWSFGIL 447 Query: 540 MLEVLCARPVIDPSLPR-EMVNLAEWGMK 623 + E+ V P + E+++ E G + Sbjct: 448 LTELTTKGRVPYPGMVNGEVLDRVERGYR 476
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/127 (37%), Positives = 69/127 (54%), Gaps = 1/127 (0%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 ++V EYMENG++ + L D Q + + G G+ YL S IHRD+ + N Sbjct: 77 MIVTEYMENGSLDAFLRTHDG-QFTILQLVGMLKGVGAGMRYL---SDLGYIHRDLAARN 132 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 IL+D L+ KV+DFGLS+ + + +TA K + PE + + SDV+SFG Sbjct: 133 ILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFG 192 Query: 534 VVMLEVL 554 VVM EVL Sbjct: 193 VVMWEVL 199
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 68.6 bits (166), Expect = 2e-11 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 19/155 (12%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTV-----KSHLYGSDNP---------SLNWKQRLEICIGA 284 +G C+ R + L EY +G + KS + +D +L+ +Q L Sbjct: 887 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADV 946 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL S K IHRD+ + NIL+ EN +AK+ADFGLS+ G E+ VK + Sbjct: 947 ARGMDYL---SQKQFIHRDLAARNILVGENYIAKIADFGLSR-GQEV-------YVKKTM 995 Query: 465 GYLDPEYFRRQQL-----TEKSDVYSFGVVMLEVL 554 G L + + L T SDV+S+GV++ E++ Sbjct: 996 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIV 1030
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/136 (30%), Positives = 71/136 (52%) Frame = +3 Query: 168 NEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVK 347 ++ +V E+++ T+K ++ + N L + +EI + H+ IIHRD+K Sbjct: 84 SQQYIVMEFVDGMTLKQYI--NQNAPLANDEAIEIITEILSAMDMAHS---HGIIHRDLK 138 Query: 348 SANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N+L+ + KV DFG++K E T +T + GS YL PE R T +SD+Y+ Sbjct: 139 PQNVLVSSSGTVKVTDFGIAKALSETSLTQTNT-MFGSVHYLSPEQARGSNATVQSDIYA 197 Query: 528 FGVVMLEVLCARPVID 575 G+++ E+L + D Sbjct: 198 IGIILFELLTGQIPFD 213
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EY+ G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 334 IVTEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 390 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 391 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 449 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 + E+ V P + RE+++ E G + Sbjct: 450 LTELTTKGRVPYPGMVNREVLDQVERGYR 478
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 68.6 bits (166), Expect = 2e-11 Identities = 44/161 (27%), Positives = 85/161 (52%), Gaps = 4/161 (2%) Frame = +3 Query: 93 RTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKS--HLYGS-DNPSLNWKQR 263 R+E+ +G+ ++ N L EY+ G+V S +YG D P + Sbjct: 1226 RSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIK---- 1281 Query: 264 LEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVS 443 + +GL YLH+ K I+HRD+K+ N+LLD++ + K++DFG+S+ ++ ++ Sbjct: 1282 -HLTTQVLKGLAYLHS---KGILHRDMKADNLLLDQDGICKISDFGISRKSKDI-YSNSD 1336 Query: 444 TAVKGSFGYLDPEYF-RRQQLTEKSDVYSFGVVMLEVLCAR 563 ++G+ ++ PE +Q + K D++S G ++LE+ + Sbjct: 1337 MTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGK 1377
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ EYMENG++ + L +D Q + + G G+ YL S + +HRD+ + Sbjct: 694 VMIITEYMENGSLDAFLRKNDG-RFTVIQLVGMLRGIGSGMKYL---SDMSYVHRDLAAR 749 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFG+S+ + + + + K + PE ++ T SDV+S+ Sbjct: 750 NILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSY 809 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 810 GIVMWEVMSYGERPYWDMS 828
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (CD333 antigen) Length = 806 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/177 (26%), Positives = 84/177 (47%), Gaps = 15/177 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNW--------------KQRLEICIGA 284 +G C + + ++ EY G ++ L P L++ K + Sbjct: 542 LGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQV 601 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL +++ IHRD+ + N+L+ E+ + K+ADFGL++ LD +T + Sbjct: 602 ARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 658 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 ++ PE + T +SDV+SFGV++ E+ P +P E+ L + G + K Sbjct: 659 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 715
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/177 (25%), Positives = 85/177 (48%), Gaps = 15/177 (8%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNW--------------KQRLEICIGA 284 +G C + + ++ EY G ++ +L P +++ K + Sbjct: 536 LGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQV 595 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL +++ IHRD+ + N+L+ E+ + K+ADFGL++ +D +T + Sbjct: 596 ARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPV 652 Query: 465 GYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSLP-REMVNLAEWGMKWQK 632 ++ PE + T +SDV+SFGV++ E+ P +P E+ L + G + K Sbjct: 653 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 709
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ EYMENG++ + L +D Q + + G G+ YL S + +HRD+ + Sbjct: 695 VMIITEYMENGSLDAFLRKNDG-RFTVIQLVGMLRGIGSGMKYL---SDMSYVHRDLAAR 750 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFG+S+ + + + + K + PE ++ T SDV+S+ Sbjct: 751 NILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSY 810 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 811 GIVMWEVMSYGERPYWDMS 829
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ EYMENG++ + L +D Q + + G G+ YL S + +HRD+ + Sbjct: 695 VMIITEYMENGSLDAFLRKNDG-RFTVIQLVGMLRGIGSGMKYL---SDMSYVHRDLAAR 750 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFG+S+ + + + + K + PE ++ T SDV+S+ Sbjct: 751 NILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSY 810 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 811 GIVMWEVMSYGERPYWDMS 829
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 3/139 (2%) Frame = +3 Query: 174 MILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++++ EYMENG++ + L +D Q + + G G+ YL S + +HRD+ + Sbjct: 695 VMIITEYMENGSLDAFLRKNDG-RFTVIQLVGMLRGIGSGMKYL---SDMSYVHRDLAAR 750 Query: 354 NILLDENLLAKVADFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSF 530 NIL++ NL+ KV+DFG+S+ + + + + K + PE ++ T SDV+S+ Sbjct: 751 NILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSY 810 Query: 531 GVVMLEVLC--ARPVIDPS 581 G+VM EV+ RP D S Sbjct: 811 GIVMWEVMSYGERPYWDMS 829
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSLPR-EMVNLAEWGMK 623 + E+ V P + E+++ E G + Sbjct: 451 LTELTTKGRVPYPGMGNGEVLDRVERGYR 479
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V EYM G++ L G L Q +++ A G+ Y+ + +HRD+++ANI Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANI 391 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ KVADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 392 LVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 450 Query: 540 MLEVLCARPVIDPSLPR-EMVNLAEWGMK 623 + E+ V P + E+++ E G + Sbjct: 451 LTELTTKGRVPYPGMGNGEVLDRVERGYR 479
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 2/168 (1%) Frame = +3 Query: 87 EFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGTVKS--HLYGSDNPSLNWKQ 260 +FR E+E GY + + L+ EY+ NG + L+G N L Sbjct: 148 QFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDY 207 Query: 261 RLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHV 440 +I A L Y+H K IIHRD+K NIL+ N + K+ DFG S P ++ Sbjct: 208 IYQI----ANALDYMHK---KNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENR--- 257 Query: 441 STAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVLCARPVIDPSL 584 V G+ YL PE ++ D ++ GV+ E+L P + + Sbjct: 258 RKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEM 305
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 68.2 bits (165), Expect = 2e-11 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 1/149 (0%) Frame = +3 Query: 180 LVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANI 359 +V E+M G++ L D L Q +++ A G+ Y+ + IHRD+++ANI Sbjct: 341 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMN---YIHRDLRAANI 397 Query: 360 LLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVV 539 L+ ENL+ K+ADFGL++ + + T K + PE + T KSDV+SFG++ Sbjct: 398 LVGENLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 456 Query: 540 MLEVLCARPVIDPSL-PREMVNLAEWGMK 623 E+ V P + RE++ E G + Sbjct: 457 QTELTTKGRVPYPGMVNREVLEQVERGYR 485
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/129 (32%), Positives = 73/129 (56%), Gaps = 3/129 (2%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYG-SDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSA 353 ++V YM++G +++ + + NP++ K + + A+G+ YL +K +HRD+ + Sbjct: 1155 LVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---VSKKFVHRDLAAR 1209 Query: 354 NILLDENLLAKVADFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYS 527 N +LDE KVADFGL++ E H T K ++ E + Q+ T KSDV+S Sbjct: 1210 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS 1269 Query: 528 FGVVMLEVL 554 FGV++ E++ Sbjct: 1270 FGVLLWELM 1278
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 68.2 bits (165), Expect = 2e-11 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 19/155 (12%) Frame = +3 Query: 147 IGYCDERNEMILVYEYMENGTV-----KSHLYGSDNP---------SLNWKQRLEICIGA 284 +G C+ R + L EY +G + KS + +D +L+ +Q L Sbjct: 890 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADV 949 Query: 285 ARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSF 464 ARG+ YL S K IHRD+ + NIL+ EN +AK+ADFGLS+ G E+ VK + Sbjct: 950 ARGMDYL---SQKQFIHRDLAARNILVGENYVAKIADFGLSR-GQEV-------YVKKTM 998 Query: 465 GYLDPEYFRRQQL-----TEKSDVYSFGVVMLEVL 554 G L + + L T SDV+S+GV++ E++ Sbjct: 999 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIV 1033
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 68.2 bits (165), Expect = 2e-11 Identities = 44/134 (32%), Positives = 69/134 (51%) Frame = +3 Query: 150 GYCDERNEMILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAI 329 G C ++ + +V E+ME G + + L + L +C G+ YL S Sbjct: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRDVLLSMCQDVCEGMEYLERNS---F 485 Query: 330 IHRDVKSANILLDENLLAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTE 509 IHRD+ + N L+ E + KV+DFG+++ + DQ S+ K + PE F + + Sbjct: 486 IHRDLAARNCLVSEAGVVKVSDFGMARYFLD-DQYTSSSGAKFPVKWCPPEVFNYSRFSS 544 Query: 510 KSDVYSFGVVMLEV 551 KSDV+SFGV+M EV Sbjct: 545 KSDVWSFGVLMWEV 558
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 68.2 bits (165), Expect = 2e-11 Identities = 47/127 (37%), Positives = 69/127 (54%), Gaps = 1/127 (0%) Frame = +3 Query: 177 ILVYEYMENGTVKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSAN 356 ++V EYMENG++ + L D Q + + G G+ YL S IHRD+ + N Sbjct: 709 MIVTEYMENGSLDAFLRTHDG-QFTIVQLVGMLRGVGAGMRYL---SDLGYIHRDLAARN 764 Query: 357 ILLDENLLAKVADFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYFRRQQLTEKSDVYSFG 533 +L+D L+ KV+DFGLS+ + + +TA K + PE + + SDV+SFG Sbjct: 765 VLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFG 824 Query: 534 VVMLEVL 554 VVM EVL Sbjct: 825 VVMWEVL 831
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 68.2 bits (165), Expect = 2e-11 Identities = 46/175 (26%), Positives = 80/175 (45%) Frame = +3 Query: 30 DDTKVAVKRGNPKSQQGLNEFRTEIEXXXXXXXXXXXXXIGYCDERNEMILVYEYMENGT 209 + TKVAVK P + + F E + ++ EYM G+ Sbjct: 267 NSTKVAVKTLKPGTMS-VQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGS 325 Query: 210 VKSHLYGSDNPSLNWKQRLEICIGAARGLHYLHTGSAKAIIHRDVKSANILLDENLLAKV 389 + L + + + ++ A G+ Y+ K IHRD+++AN+L+ E+L+ K+ Sbjct: 326 LLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLMCKI 382 Query: 390 ADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMLEVL 554 ADFGL++ + + T K + PE T KSDV+SFG+++ E++ Sbjct: 383 ADFGLARVIEDNEYT-AREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIV 436 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 93,704,571 Number of Sequences: 219361 Number of extensions: 1973851 Number of successful extensions: 8383 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7028 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7384 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6143359464 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
