ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags33c20 |
|---|---|
| Clone Library Name | barley_pub |
>WRK19_ARATH (Q9SZ67) Probable WRKY transcription factor 19 (WRKY DNA-binding| protein 19) Length = 1895 Score = 141 bits (355), Expect = 2e-33 Identities = 79/132 (59%), Positives = 93/132 (70%), Gaps = 5/132 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYW--MAPEVV-NPKKT--YGPAADIWSLGCT 166 ANG+VKLADFGLAK + S T YW MAPEV+ NPK YG ADIWSLGCT Sbjct: 1759 ANGTVKLADFGLAK-------VMSLWRTPYWNWMAPEVILNPKDYDGYGTPADIWSLGCT 1811 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 VLEMLT Q+PY DLE ALY IG G+ P IP +S +ARDFI C+K NPE+RP+A++L Sbjct: 1812 VLEMLTGQIPYSDLEIGTALYNIGTGKLPKIPDILSLDARDFILTCLKVNPEERPTAAEL 1871 Query: 347 LDHPFVNRSMRS 382 L+HPFVN + S Sbjct: 1872 LNHPFVNMPLPS 1883
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 108 bits (269), Expect = 2e-23 Identities = 61/153 (39%), Positives = 96/153 (62%), Gaps = 14/153 (9%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKL--NVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 +G K++DFG+++++ + N + +GTV+WMAPE+V+ K+ Y DIWSLGC VLEM Sbjct: 1314 DGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEM 1373 Query: 179 LTRQLPYPDLEWTQALYRIGKGE-PPAIPS----AISKEARDFISQCVKPNPEDRPSASK 343 + P+ +LE A+++IGK + P IP IS+ R+F+ C + NPE RP+A++ Sbjct: 1374 FAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANE 1433 Query: 344 LLDHPF--VN-----RSMRSIRSMRTYTRPNSS 421 LL HPF VN +S R + +++ + NSS Sbjct: 1434 LLSHPFSEVNETFNFKSTRLAKFIKSNDKLNSS 1466
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 108 bits (269), Expect = 2e-23 Identities = 61/134 (45%), Positives = 86/134 (64%), Gaps = 6/134 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVL---KSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 G +KLADFG +KQ ++L + KS KGT YWMAPEV+ + + +ADIWS+GCTV+EM Sbjct: 208 GCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVIL-QTGHSFSADIWSVGCTVIEM 266 Query: 179 LTRQLPYPD-LEWTQALYRIG--KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 +T + P+ + A++ IG K PP IP IS +A DF+ +C++ P RP+AS+LL Sbjct: 267 VTGKAPWSQQYKEIAAIFHIGTTKSHPP-IPDNISSDANDFLLKCLQQEPNLRPTASELL 325 Query: 350 DHPFVNRSMRSIRS 391 HPFV + S Sbjct: 326 KHPFVTGKQKESAS 339
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 106 bits (265), Expect = 5e-23 Identities = 59/125 (47%), Positives = 85/125 (68%), Gaps = 6/125 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVL---KSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 G +KLADFG +KQ ++L + KS KGT YWMAPEV+ + + +ADIWS+GCTV+EM Sbjct: 209 GCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVIL-QTGHSFSADIWSVGCTVIEM 267 Query: 179 LTRQLPYPD-LEWTQALYRIG--KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 +T + P+ + A++ IG K PP IP +S +A+DF+ +C++ P RP+AS+LL Sbjct: 268 VTGKAPWSQQYKEVAAIFFIGTTKSHPP-IPDTLSSDAKDFLLKCLQEVPNLRPTASELL 326 Query: 350 DHPFV 364 HPFV Sbjct: 327 KHPFV 331
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 105 bits (263), Expect = 9e-23 Identities = 58/122 (47%), Positives = 80/122 (65%), Gaps = 2/122 (1%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK--SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 +G++KLADFG+A +K+N L+ S G+ YWMAPEV+ A+DIWS+GCTV+E+ Sbjct: 142 DGTIKLADFGVA---TKINALEDHSVVGSPYWMAPEVIELVGAT-TASDIWSVGCTVIEL 197 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 L PY DL+ T AL+R+ K E P +PS IS A+ F+ QC + +P R KLL HP Sbjct: 198 LDGNPPYYDLDPTSALFRMVKDEHPPLPSNISSAAKSFLMQCFQKDPNLRIKTRKLLKHP 257 Query: 359 FV 364 +V Sbjct: 258 WV 259
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 102 bits (255), Expect = 8e-22 Identities = 52/124 (41%), Positives = 79/124 (63%), Gaps = 4/124 (3%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLK----SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLE 175 G VK+ DFG++K+ S LN + S +G+V+WM+PEVV T A DIWS GC V+E Sbjct: 612 GCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKA-DIWSTGCVVIE 670 Query: 176 MLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 M T + P+PD QA+++IG P IPS + E ++F+ + + + + RPSA +LL H Sbjct: 671 MFTGKHPFPDFSQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQH 730 Query: 356 PFVN 367 P+++ Sbjct: 731 PWLD 734
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 102 bits (255), Expect = 8e-22 Identities = 55/131 (41%), Positives = 79/131 (60%), Gaps = 9/131 (6%) Frame = +2 Query: 8 GSVKLADFGLAKQTS-------KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 G +KL DFG A++ + ++LKS GT YWMAPEV+N + YG +DIWS+GCT Sbjct: 1198 GIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN-ESGYGRKSDIWSIGCT 1256 Query: 167 VLEMLTRQLPYPDLEWTQALYRIG--KGEPPAIPSAISKEARDFISQCVKPNPEDRPSAS 340 V EM T + P ++ A++ IG +G P +P S+ A DF+ C+ + +RPSA Sbjct: 1257 VFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSAL 1316 Query: 341 KLLDHPFVNRS 373 +LL H F+ RS Sbjct: 1317 QLLKHSFLERS 1327
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 102 bits (253), Expect = 1e-21 Identities = 63/137 (45%), Positives = 85/137 (62%), Gaps = 7/137 (5%) Frame = +2 Query: 8 GSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVV---NPKKT-YGPAADIWSLGCTVL 172 G ++LADFG+ AK L S GT YWMAPEVV K T Y ADIWSLG T++ Sbjct: 169 GDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLI 228 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 EM + P+ +L + L +I K +PP + PS S E RDF+ + NPE RPSA++L Sbjct: 229 EMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQL 288 Query: 347 LDHPFVNRSMRSIRSMR 397 L+HPFV+ S+ S +++R Sbjct: 289 LEHPFVS-SITSNKALR 304
>STK10_MOUSE (O55098) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 966 Score = 101 bits (252), Expect = 2e-21 Identities = 61/138 (44%), Positives = 82/138 (59%), Gaps = 9/138 (6%) Frame = +2 Query: 8 GSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTVL 172 G ++LADFG+ AK L S GT YWMAPEVV Y ADIWSLG T++ Sbjct: 169 GDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLI 228 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 EM + P+ +L + L +I K +PP + PS S E RDF+ + NPE RPSA++L Sbjct: 229 EMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQL 288 Query: 347 LDHPFVNR--SMRSIRSM 394 L HPFV+R S +++R + Sbjct: 289 LQHPFVSRVTSNKALREL 306
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 101 bits (251), Expect = 2e-21 Identities = 54/127 (42%), Positives = 78/127 (61%), Gaps = 7/127 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQ-------TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 G +K++DFG++K+ T S +G+ +WMAPEVV + + DIWSLGC Sbjct: 534 GKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVK-QTMHTEKTDIWSLGCL 592 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 V+EMLT + PYP+ + QA++RIG+ P PS IS A DF+ + + RP+AS+L Sbjct: 593 VIEMLTSKHPYPNCDQMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASEL 652 Query: 347 LDHPFVN 367 L HPFV+ Sbjct: 653 LSHPFVS 659
>M3K4_HUMAN (Q9Y6R4) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 100 bits (249), Expect = 4e-21 Identities = 54/129 (41%), Positives = 80/129 (62%), Gaps = 8/129 (6%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKL-----NVLKSCKGTVYWMAPEVVNPKKT--YGPAADIWSLG 160 ++G +KL DFG + + + S GT +MAPEV+ K +G AADIWSLG Sbjct: 1472 SSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLG 1531 Query: 161 CTVLEMLTRQLPYPDLEWT-QALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSA 337 C V+EM+T + P+ + E Q +Y++G G P IP +S E +DF+S C++ +P+ R +A Sbjct: 1532 CVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTA 1591 Query: 338 SKLLDHPFV 364 S+LLDH FV Sbjct: 1592 SQLLDHSFV 1600
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 99.4 bits (246), Expect = 8e-21 Identities = 56/124 (45%), Positives = 81/124 (65%), Gaps = 5/124 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKL---NVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 G ++LADFG +K+ +L N KS KGT YWMAPEV+ + + +ADIWS+GCTV+EM Sbjct: 208 GCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVIL-QTGHSFSADIWSVGCTVIEM 266 Query: 179 LTRQLPYPD-LEWTQALYRIGKGEP-PAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 T + P+ + + A+ IG+ + P IP +S EA+DF+ +C+ P R SA++LL Sbjct: 267 ATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQ 326 Query: 353 HPFV 364 HPFV Sbjct: 327 HPFV 330
>M3K4_MOUSE (O08648) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 97.4 bits (241), Expect = 3e-20 Identities = 53/129 (41%), Positives = 79/129 (61%), Gaps = 8/129 (6%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKL-----NVLKSCKGTVYWMAPEVVNPKKT--YGPAADIWSLG 160 ++G +KL DFG + + + S GT +MAPEV+ K +G AADIWSLG Sbjct: 1462 SSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLG 1521 Query: 161 CTVLEMLTRQLPYPDLEWT-QALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSA 337 C V+EM+T + P+ + E Q +Y++G G P IP +S E + F+S C++ +P+ R +A Sbjct: 1522 CVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTA 1581 Query: 338 SKLLDHPFV 364 S+LLDH FV Sbjct: 1582 SQLLDHAFV 1590
>SLK_RAT (O08815) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1206 Score = 97.1 bits (240), Expect = 4e-20 Identities = 54/127 (42%), Positives = 77/127 (60%), Gaps = 7/127 (5%) Frame = +2 Query: 5 NGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 +G +KLADFG+ AK T + S GT YWMAPEVV + + Y AD+WSLG T+ Sbjct: 166 DGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL 225 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASK 343 +EM + P+ +L + L +I K EPP + PS S +DF+ +C++ N + R + S+ Sbjct: 226 IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQ 285 Query: 344 LLDHPFV 364 LL HPFV Sbjct: 286 LLQHPFV 292
>SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC 2.7.11.1)| (STE20-like kinase sid1) Length = 471 Score = 97.1 bits (240), Expect = 4e-20 Identities = 53/122 (43%), Positives = 73/122 (59%), Gaps = 1/122 (0%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 + G+VKLADFG+A Q S + + GT +WMAPEV+ + +YG AADIWSLG T +EM Sbjct: 140 STGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQ-QTSYGLAADIWSLGITAIEM 198 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 P + + ++ I + EPP + S RDF+S C+ NP R SA +LL HP Sbjct: 199 ANGIPPRATMHPMRVIFEIPQSEPPKLDDHFSPTFRDFVSCCLDLNPNMRWSAKELLQHP 258 Query: 359 FV 364 F+ Sbjct: 259 FI 260
>NINAC_DROME (P10676) Neither inactivation nor afterpotential protein C (EC| 2.7.11.1) Length = 1501 Score = 97.1 bits (240), Expect = 4e-20 Identities = 51/139 (36%), Positives = 86/139 (61%), Gaps = 7/139 (5%) Frame = +2 Query: 5 NGSVKLADFGLAKQT-SKLNVLKSCKGTVYWMAPEVVNPKKTYGP----AADIWSLGCTV 169 NG VKL DFGL++Q S L +C G+ WMAPEVV+ ++ P AD+W+LG T Sbjct: 156 NGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMESREPDITVRADVWALGITT 215 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASK 343 +E+ + P+ D+ T+A+++I + PP + P+ S++ DFIS+ ++ N E+RP + Sbjct: 216 IELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVE 275 Query: 344 LLDHPFVNRSMRSIRSMRT 400 +++HPF+ + + MR+ Sbjct: 276 MVEHPFLTELIENEDEMRS 294
>SLK_HUMAN (Q9H2G2) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9) Length = 1235 Score = 97.1 bits (240), Expect = 4e-20 Identities = 54/127 (42%), Positives = 77/127 (60%), Gaps = 7/127 (5%) Frame = +2 Query: 5 NGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 +G +KLADFG+ AK T + S GT YWMAPEVV + + Y AD+WSLG T+ Sbjct: 166 DGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL 225 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASK 343 +EM + P+ +L + L +I K EPP + PS S +DF+ +C++ N + R + S+ Sbjct: 226 IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQ 285 Query: 344 LLDHPFV 364 LL HPFV Sbjct: 286 LLQHPFV 292
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 97.1 bits (240), Expect = 4e-20 Identities = 54/127 (42%), Positives = 77/127 (60%), Gaps = 7/127 (5%) Frame = +2 Query: 5 NGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 +G +KLADFG+ AK T + S GT YWMAPEVV + + Y AD+WSLG T+ Sbjct: 166 DGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL 225 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASK 343 +EM + P+ +L + L +I K EPP + PS S +DF+ +C++ N + R + S+ Sbjct: 226 IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQ 285 Query: 344 LLDHPFV 364 LL HPFV Sbjct: 286 LLQHPFV 292
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 96.7 bits (239), Expect = 5e-20 Identities = 48/126 (38%), Positives = 74/126 (58%), Gaps = 1/126 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G VKLADFG+A Q + + ++ GT +WMAPEV+ + Y ADIWSLG T +E+ Sbjct: 167 HGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELA 225 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + P+ +L + L+ I K PP + SK ++F+ C+ P RP+A +LL H F Sbjct: 226 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285 Query: 362 VNRSMR 379 + R+ + Sbjct: 286 ILRNAK 291
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 96.7 bits (239), Expect = 5e-20 Identities = 54/127 (42%), Positives = 77/127 (60%), Gaps = 7/127 (5%) Frame = +2 Query: 5 NGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 +G +KLADFG+ AK T + S GT YWMAPEVV + + Y AD+WSLG T+ Sbjct: 166 DGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL 225 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASK 343 +EM + P+ +L + L +I K EPP + PS S +DF+ +C++ N + R + S+ Sbjct: 226 IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQ 285 Query: 344 LLDHPFV 364 LL HPFV Sbjct: 286 LLQHPFV 292
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 96.7 bits (239), Expect = 5e-20 Identities = 48/126 (38%), Positives = 74/126 (58%), Gaps = 1/126 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G VKLADFG+A Q + + ++ GT +WMAPEV+ + Y ADIWSLG T +E+ Sbjct: 155 HGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELA 213 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + P+ +L + L+ I K PP + SK ++F+ C+ P RP+A +LL H F Sbjct: 214 KGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273 Query: 362 VNRSMR 379 + R+ + Sbjct: 274 IIRNAK 279
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 95.9 bits (237), Expect = 9e-20 Identities = 54/122 (44%), Positives = 73/122 (59%), Gaps = 3/122 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 380 GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVE 438 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY + +ALY I P + P +S RDF+++C++ + E R SA +LL HP Sbjct: 439 GEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHP 498 Query: 359 FV 364 F+ Sbjct: 499 FL 500
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 95.9 bits (237), Expect = 9e-20 Identities = 54/122 (44%), Positives = 73/122 (59%), Gaps = 3/122 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 380 GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVE 438 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY + +ALY I P + P +S RDF+++C++ + E R SA +LL HP Sbjct: 439 GEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHP 498 Query: 359 FV 364 F+ Sbjct: 499 FL 500
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 95.9 bits (237), Expect = 9e-20 Identities = 54/122 (44%), Positives = 73/122 (59%), Gaps = 3/122 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 380 GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVE 438 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY + +ALY I P + P +S RDF+++C++ + E R SA +LL HP Sbjct: 439 GEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHP 498 Query: 359 FV 364 F+ Sbjct: 499 FL 500
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 95.9 bits (237), Expect = 9e-20 Identities = 54/122 (44%), Positives = 73/122 (59%), Gaps = 3/122 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 380 GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVE 438 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY + +ALY I P + P +S RDF+++C++ + E R SA +LL HP Sbjct: 439 GEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHP 498 Query: 359 FV 364 F+ Sbjct: 499 FL 500
>STK25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 95.1 bits (235), Expect = 2e-19 Identities = 49/122 (40%), Positives = 71/122 (58%), Gaps = 1/122 (0%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G VKLADFG+A Q + + ++ GT +WMAPEV+ + Y ADIWSLG T +E+ Sbjct: 152 GDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK-QSAYDFKADIWSLGITAIELAK 210 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + P DL + L+ I K PP + SK ++F+ C+ +P RP+A +LL H F+ Sbjct: 211 GEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFI 270 Query: 365 NR 370 R Sbjct: 271 TR 272
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/123 (43%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMV 471 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + + R SA +LL H Sbjct: 472 EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQH 531 Query: 356 PFV 364 PF+ Sbjct: 532 PFL 534
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/123 (43%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMV 471 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + + R SA +LL H Sbjct: 472 EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQH 531 Query: 356 PFV 364 PF+ Sbjct: 532 PFL 534
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/123 (43%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMV 471 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + + R SA +LL H Sbjct: 472 EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQH 531 Query: 356 PFV 364 PF+ Sbjct: 532 PFL 534
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/123 (43%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMV 471 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + + R SA +LL H Sbjct: 472 EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQH 531 Query: 356 PFV 364 PF+ Sbjct: 532 PFL 534
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 95.1 bits (235), Expect = 2e-19 Identities = 55/133 (41%), Positives = 76/133 (57%), Gaps = 3/133 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G KLADFG+A Q T + + GT +WMAPEV+ + Y ADIWSLG T +EM Sbjct: 161 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-EIGYNCVADIWSLGITAIEMAE 219 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY D+ +A++ I PP P S DF+ QC+ +PE R +A++LL HP Sbjct: 220 GKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHP 279 Query: 359 FVNRSMRSIRSMR 397 FV RS + + +R Sbjct: 280 FV-RSAKGVSILR 291
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/123 (43%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 398 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMV 456 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + + R SA +LL H Sbjct: 457 EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQH 516 Query: 356 PFV 364 PF+ Sbjct: 517 PFL 519
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 94.7 bits (234), Expect = 2e-19 Identities = 50/129 (38%), Positives = 81/129 (62%), Gaps = 9/129 (6%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKL---NVLKSCKGTVYWMAPEVV-NPKKTYGPAADIWSLGCTVL 172 +G K++DFG++K + + + S +G+++WMAPEV+ N + Y D+WSLGC VL Sbjct: 966 DGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVL 1025 Query: 173 EMLTRQLPYPDLEWTQALYRIG-KGEPPAIP----SAISKEARDFISQCVKPNPEDRPSA 337 EML + P+ E QA++++G + + P IP S +S EA F++ C N + RP+A Sbjct: 1026 EMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTA 1085 Query: 338 SKLLDHPFV 364 +LL+HPF+ Sbjct: 1086 EELLNHPFM 1094
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 94.4 bits (233), Expect = 3e-19 Identities = 52/123 (42%), Positives = 78/123 (63%), Gaps = 5/123 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNV----LKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLE 175 G+VKL DFG +K+ + + ++S GT YWM+PEV++ + YG AD+WSLGCTV+E Sbjct: 501 GNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEG-YGRKADVWSLGCTVVE 559 Query: 176 MLTRQLPYPDLEWTQALYRIG-KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 MLT + P+ + E A+++I + P +PS IS+ RDF+ + + RPSA +LL Sbjct: 560 MLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLT 618 Query: 353 HPF 361 H F Sbjct: 619 HHF 621
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 94.4 bits (233), Expect = 3e-19 Identities = 52/123 (42%), Positives = 78/123 (63%), Gaps = 5/123 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNV----LKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLE 175 G+VKL DFG +K+ + + ++S GT YWM+PEV++ + YG AD+WSLGCTV+E Sbjct: 501 GNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEG-YGRKADVWSLGCTVVE 559 Query: 176 MLTRQLPYPDLEWTQALYRIG-KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 MLT + P+ + E A+++I + P +PS IS+ RDF+ + + RPSA +LL Sbjct: 560 MLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLT 618 Query: 353 HPF 361 H F Sbjct: 619 HHF 621
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 94.0 bits (232), Expect = 4e-19 Identities = 47/125 (37%), Positives = 73/125 (58%), Gaps = 1/125 (0%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G VKLADFG+A Q + + ++ GT +WMAPEV+ + Y ADIWSLG T +E+ Sbjct: 156 GDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ-QSAYDSKADIWSLGITAIELAK 214 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + P D+ + L+ I K PP + +K ++FI C+ +P RP+A +LL H F+ Sbjct: 215 GEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 274 Query: 365 NRSMR 379 ++ + Sbjct: 275 VKNSK 279
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 94.0 bits (232), Expect = 4e-19 Identities = 48/122 (39%), Positives = 71/122 (58%), Gaps = 1/122 (0%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G VK+ADFG+A Q + + ++ GT +WMAPEV+ + Y ADIWSLG T +E+ Sbjct: 152 GDVKMADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK-QSAYDFKADIWSLGITAIELAK 210 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + P DL + L+ I K PP + SK ++F+ C+ +P RP+A +LL H F+ Sbjct: 211 GEPPNSDLHPMRVLFLIPKNNPPTLEGHHSKPFKEFVEACLNKDPRFRPTAKELLKHKFI 270 Query: 365 NR 370 R Sbjct: 271 TR 272
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 94.0 bits (232), Expect = 4e-19 Identities = 50/122 (40%), Positives = 73/122 (59%), Gaps = 3/122 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCK-GTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G +KL DFG Q ++LN+ ++ GT YWMAPEVV+ +K YGP DIWSLG ++EM+ Sbjct: 751 GDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVS-RKEYGPKVDIWSLGIMIIEMIE 809 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY + +ALY I P + P +S + F+ C+ PEDR SA++LL Sbjct: 810 GEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDE 869 Query: 359 FV 364 ++ Sbjct: 870 YI 871
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 93.6 bits (231), Expect = 5e-19 Identities = 47/125 (37%), Positives = 73/125 (58%), Gaps = 1/125 (0%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G VKLADFG+A Q + + ++ GT +WMAPEV+ + Y ADIWSLG T +E+ Sbjct: 156 GDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ-QSAYDSKADIWSLGITAIELAK 214 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + P D+ + L+ I K PP + +K ++FI C+ +P RP+A +LL H F+ Sbjct: 215 GEPPNSDMHPMRVLFLIPKNNPPTLIGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 274 Query: 365 NRSMR 379 ++ + Sbjct: 275 VKNSK 279
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 93.6 bits (231), Expect = 5e-19 Identities = 53/123 (43%), Positives = 73/123 (59%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 400 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMI 458 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + E R SA +LL H Sbjct: 459 EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQH 518 Query: 356 PFV 364 F+ Sbjct: 519 QFL 521
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 93.6 bits (231), Expect = 5e-19 Identities = 51/125 (40%), Positives = 72/125 (57%), Gaps = 3/125 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G KLADFG+A Q T + + GT +WMAPEV+ + Y ADIWSLG T +EM Sbjct: 158 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-EIGYNCVADIWSLGITSIEMAE 216 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY D+ +A++ I PP P S + DF+ +C+ NPE R +A++LL HP Sbjct: 217 GKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHP 276 Query: 359 FVNRS 373 F+ + Sbjct: 277 FIKNA 281
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 93.6 bits (231), Expect = 5e-19 Identities = 53/123 (43%), Positives = 73/123 (59%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 399 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMI 457 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+++C++ + E R SA +LL H Sbjct: 458 EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQH 517 Query: 356 PFV 364 F+ Sbjct: 518 QFL 520
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 93.6 bits (231), Expect = 5e-19 Identities = 54/147 (36%), Positives = 92/147 (62%), Gaps = 4/147 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNP-KKTYGPAADIWSLGCTVLEM 178 +G +K++DFG +K+ + +N ++ GT+ +MAPE+++ + YG AADIWSLGCT++EM Sbjct: 822 SGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEM 881 Query: 179 LTRQLPYPDL-EWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 T + P+ +L E A++++G + P IP ++S EA+ FI +C +P+P+ R A+ LL Sbjct: 882 ATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLI 941 Query: 353 HPFVNRSMRSIRSMRTYTRPNSSTRGT 433 F+ + S + T+P S T Sbjct: 942 DEFL-----KVSSKKKKTQPKLSALST 963
>PAK6_HUMAN (Q9NQU5) Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1)| (p21-activated kinase 6) (PAK-6) (PAK-5) Length = 681 Score = 92.8 bits (229), Expect = 8e-19 Identities = 51/123 (41%), Positives = 75/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G VKL+DFG Q SK + KS GT YWMAPEV++ + Y DIWSLG V+EM+ Sbjct: 537 DGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS-RSLYATEVDIWSLGIMVIEMV 595 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSA--ISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY QA+ R+ PP + ++ +S RDF+ + + +P++R +A +LLDH Sbjct: 596 DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDH 655 Query: 356 PFV 364 PF+ Sbjct: 656 PFL 658
>HIPPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC 2.7.11.1)| Length = 669 Score = 92.4 bits (228), Expect = 1e-18 Identities = 55/130 (42%), Positives = 78/130 (60%), Gaps = 4/130 (3%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G KLADFG+A Q T + + GT +WMAPEV+ + Y ADIWSLG T LEM Sbjct: 173 GYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE-EIGYDCVADIWSLGITALEMAE 231 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY ++ +A++ I + PP+ P S E DF+S+C+ P+DR +A++LL+H Sbjct: 232 GKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291 Query: 359 FV-NRSMRSI 385 F+ N RSI Sbjct: 292 FIRNAKHRSI 301
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 92.4 bits (228), Expect = 1e-18 Identities = 53/143 (37%), Positives = 91/143 (63%), Gaps = 4/143 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNP-KKTYGPAADIWSLGCTVLEM 178 +G +K++DFG +K+ + +N ++ GT+ +MAPE+++ + YG AADIWSLGCT++EM Sbjct: 815 SGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEM 874 Query: 179 LTRQLPYPDL-EWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 T + P+ +L E A++++G + P IP ++S EA+ FI +C +P+P+ R A+ LL Sbjct: 875 ATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLV 934 Query: 353 HPFVNRSMRSIRSMRTYTRPNSS 421 F+ + S + T+P S Sbjct: 935 DEFL-----KVSSKKKKTQPKLS 952
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 92.4 bits (228), Expect = 1e-18 Identities = 57/146 (39%), Positives = 93/146 (63%), Gaps = 7/146 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNP-KKTYGPAADIWSLGCTVLEM 178 +G +K++DFG +K+ + + ++ GT+ +MAPE+++ + YG AADIWSLGCTV+EM Sbjct: 506 SGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEM 565 Query: 179 LTRQLPYPDLEWTQ-ALYRIG--KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 T + P+ +L Q A++++G K PP +PS++S EA+ F+ + +P+P R SA LL Sbjct: 566 ATGRPPFHELGSPQAAMFQVGMYKVHPP-MPSSLSAEAQAFLLRTFEPDPRLRASAQTLL 624 Query: 350 DHPFV--NRSMRSIRSMRTYTRPNSS 421 PF+ + RS S R RP+ + Sbjct: 625 GDPFLQPGKRSRSPSSPRHAPRPSDA 650
>WIS1_SCHPO (P33886) Protein kinase wis1 (EC 2.7.12.2) (Protein kinase sty2)| Length = 605 Score = 92.0 bits (227), Expect = 1e-18 Identities = 56/156 (35%), Positives = 81/156 (51%), Gaps = 13/156 (8%) Frame = +2 Query: 2 ANGSVKLADFG----LAKQTSKLNVLKSCKGTVYWMAPEVV------NPKKTYGPAADIW 151 +NG VKL DFG L SK N+ G +MAPE + N TY AD+W Sbjct: 451 SNGQVKLCDFGVSGNLVASISKTNI-----GCQSYMAPERIRVGGPTNGVLTYTVQADVW 505 Query: 152 SLGCTVLEMLTRQLPYPDLEWTQA---LYRIGKGEPPAIPSAISKEARDFISQCVKPNPE 322 SLG T+LEM PYP +T L I G+PP++P + S EARDF+++C+ NP Sbjct: 506 SLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPDSFSPEARDFVNKCLNKNPS 565 Query: 323 DRPSASKLLDHPFVNRSMRSIRSMRTYTRPNSSTRG 430 RP +L +HP++ + + M ++ + +G Sbjct: 566 LRPDYHELANHPWLLKYQNADVDMASWAKGALKEKG 601
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 91.7 bits (226), Expect = 2e-18 Identities = 53/123 (43%), Positives = 71/123 (57%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q T + + + GT YWMAPEVV +K YGP DIWSLG +EM+ Sbjct: 400 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMI 458 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P +S RDF+ C++ + E R SA +LL H Sbjct: 459 EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLQCCLEMDVEKRGSAKELLQH 518 Query: 356 PFV 364 F+ Sbjct: 519 QFL 521
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) Length = 497 Score = 91.7 bits (226), Expect = 2e-18 Identities = 50/125 (40%), Positives = 72/125 (57%), Gaps = 3/125 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G KLADFG+A Q T + + GT +WMAPEV+ + Y ADIWSLG T +EM Sbjct: 158 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-EIGYNCVADIWSLGITSIEMAE 216 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY D+ +A++ I PP P S + DF+ +C+ +PE R +A++LL HP Sbjct: 217 GKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP 276 Query: 359 FVNRS 373 F+ + Sbjct: 277 FIKNA 281
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 90.9 bits (224), Expect = 3e-18 Identities = 51/127 (40%), Positives = 79/127 (62%), Gaps = 3/127 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A+G VKL+DFG Q S+ L KS GT YWM+PEV++ + YGP DIWSLG V+EM Sbjct: 497 ADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVIS-RLPYGPEVDIWSLGIMVIEM 555 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAIPSA--ISKEARDFISQCVKPNPEDRPSASKLLD 352 + + P+ + QA+ RI +PP + +A +S + F+ + + +P R +A++LL Sbjct: 556 VDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLA 615 Query: 353 HPFVNRS 373 HPF+ ++ Sbjct: 616 HPFLRQA 622
>M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragment) Length = 862 Score = 90.9 bits (224), Expect = 3e-18 Identities = 55/150 (36%), Positives = 80/150 (53%), Gaps = 7/150 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLE 175 NG VKLADFG++ Q T+ + KS GT YWMAPEV V K Y D+W++G T +E Sbjct: 136 NGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIE 195 Query: 176 MLTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRPSASK 343 + Q P DL +AL+ + K +PP + + S F+ + NP+ RP+A K Sbjct: 196 LAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPTAEK 255 Query: 344 LLDHPFVNRSMRSIRSMRTYTRPNSSTRGT 433 LL HPFV + + ++ + N+ T Sbjct: 256 LLQHPFVTQPLTRSLAIELLDKVNNPDHST 285
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 90.5 bits (223), Expect = 4e-18 Identities = 51/126 (40%), Positives = 72/126 (57%), Gaps = 3/126 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQT-SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G +KL DFG Q S + + GT YWMAPEVV +K YG D+WSLG +EM+ Sbjct: 517 GDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVT-RKEYGFKVDVWSLGIMAIEMVE 575 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + PY + +ALY I P I P +S DF+S+ + NP+ RPS+ +LL HP Sbjct: 576 GEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHP 635 Query: 359 FVNRSM 376 F+ +++ Sbjct: 636 FLKQAV 641
>M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) Length = 894 Score = 90.5 bits (223), Expect = 4e-18 Identities = 55/150 (36%), Positives = 80/150 (53%), Gaps = 7/150 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLE 175 NG VKLADFG++ Q T+ + KS GT YWMAPEV V K Y D+W++G T +E Sbjct: 147 NGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIE 206 Query: 176 MLTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRPSASK 343 + Q P DL +AL+ + K +PP + + S F+ + NP+ RP+A K Sbjct: 207 LAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEK 266 Query: 344 LLDHPFVNRSMRSIRSMRTYTRPNSSTRGT 433 LL HPFV + + ++ + N+ T Sbjct: 267 LLQHPFVTQHLTRSLAIELLDKVNNPDHST 296
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 90.1 bits (222), Expect = 5e-18 Identities = 51/127 (40%), Positives = 79/127 (62%), Gaps = 5/127 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNV----LKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTV 169 + G+VKL DFG +K+ + + +KS GT YWM+PEV++ + YG ADIWS+ CTV Sbjct: 493 STGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEG-YGRKADIWSVACTV 551 Query: 170 LEMLTRQLPYPDLEWTQALYRIG-KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 +EMLT + P+ + E A+++I + P +P +S RDF+ + + + RPSA +L Sbjct: 552 VEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKR-IFVEAKLRPSADEL 610 Query: 347 LDHPFVN 367 L H FV+ Sbjct: 611 LRHMFVH 617
>M3K2_MOUSE (Q61083) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 89.7 bits (221), Expect = 7e-18 Identities = 50/127 (39%), Positives = 79/127 (62%), Gaps = 5/127 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNV----LKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTV 169 + G++KL DFG +K+ + + +KS GT YWM+PEV++ + YG ADIWS+ CTV Sbjct: 493 STGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEG-YGRKADIWSVACTV 551 Query: 170 LEMLTRQLPYPDLEWTQALYRIG-KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 +EMLT + P+ + E A+++I + P +P +S RDF+ + + + RPSA +L Sbjct: 552 VEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKR-IFVEAKLRPSAEEL 610 Query: 347 LDHPFVN 367 L H FV+ Sbjct: 611 LRHMFVH 617
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 89.7 bits (221), Expect = 7e-18 Identities = 52/124 (41%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GQVKLADFGSASMASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S R+F+ C++ P+DRP++ +LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHM 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 89.7 bits (221), Expect = 7e-18 Identities = 52/124 (41%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GQVKLADFGSASMASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S R+F+ C++ P+DRP++ +LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHM 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 89.4 bits (220), Expect = 9e-18 Identities = 52/124 (41%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GQVKLADFGSASMASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S R+F+ C++ P+DRP++ +LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHI 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 89.4 bits (220), Expect = 9e-18 Identities = 47/126 (37%), Positives = 77/126 (61%), Gaps = 3/126 (2%) Frame = +2 Query: 5 NGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G++K+ DFG A+ +++ N + GT YWMAPEVV + YG DIWSLG ++EM+ Sbjct: 445 SGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNE-YGTKVDIWSLGIMIIEMI 503 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I K P + P+ +SK + F++ C+ + R +A++LL H Sbjct: 504 ENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTH 563 Query: 356 PFVNRS 373 F+N++ Sbjct: 564 SFLNQA 569
>KIC1_YEAST (P38692) Serine/threonine-protein kinase KIC1 (EC 2.7.11.1) (Kinase| that interacts with CDC31) (N-rich kinase 1) Length = 1080 Score = 88.6 bits (218), Expect = 1e-17 Identities = 48/121 (39%), Positives = 72/121 (59%), Gaps = 2/121 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G+VKL DFG+A Q ++ ++ + + GT YWMAPEV+ Y DIWSLG T E+ T Sbjct: 156 GNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIAT 215 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 PY D+E +A+ I K +PP + + S ++FI+ C+ +P++R SA LL F Sbjct: 216 GNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKF 275 Query: 362 V 364 + Sbjct: 276 I 276
>MYO3A_HUMAN (Q8NEV4) Myosin IIIA (EC 2.7.11.1)| Length = 1616 Score = 88.6 bits (218), Expect = 1e-17 Identities = 51/128 (39%), Positives = 73/128 (57%), Gaps = 7/128 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKK----TYGPAADIWSLGCTVL 172 G VKL DFG++ Q TS + + GT +WMAPEV+ ++ TY D WSLG T + Sbjct: 162 GGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAI 221 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 E+ P DL +AL++I + PP + P S E DFIS+C+ + E RP+ S+L Sbjct: 222 ELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSEL 281 Query: 347 LDHPFVNR 370 L H F+ + Sbjct: 282 LQHKFITQ 289
>TAO1B_XENLA (Q7ZYJ0) Serine/threonine-protein kinase TAO1-B (EC 2.7.11.1)| (Thousand and one amino acid protein 1-B) Length = 1001 Score = 87.8 bits (216), Expect = 3e-17 Identities = 52/124 (41%), Positives = 69/124 (55%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GQVKLADFGSASIVSPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCVELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S R+F+ C+ P+DRP++ +LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPTLQSTEWSDYFRNFVDSCLHKIPQDRPTSDELLKHM 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 87.4 bits (215), Expect = 3e-17 Identities = 51/123 (41%), Positives = 69/123 (56%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCK-GTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +GSVKL DFG Q S ++ GT YWMAPEVV +K YGP D+WSLG +EM+ Sbjct: 425 DGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVT-RKQYGPKVDVWSLGIMAIEMV 483 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEA--RDFISQCVKPNPEDRPSASKLLDH 355 + PY + +A+Y I P P S +DF+ ++ E+R SAS+LL H Sbjct: 484 EGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTH 543 Query: 356 PFV 364 PF+ Sbjct: 544 PFL 546
>TAOK3_RAT (Q53UA7) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Axotomy-related gene 357 protein) Length = 898 Score = 87.4 bits (215), Expect = 3e-17 Identities = 50/124 (40%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y DIWSLG T +E+ Sbjct: 159 GQVKLADFGSASMASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELA 215 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEA-RDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + + P + S ++ R F+ C+ P++RP+A++LL H Sbjct: 216 ERKPPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERPAAAELLRHD 275 Query: 359 FVNR 370 F+ R Sbjct: 276 FIRR 279
>TAOK3_CHICK (Q9I9E0) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Kinase from chicken) Length = 898 Score = 87.4 bits (215), Expect = 3e-17 Identities = 51/124 (41%), Positives = 69/124 (55%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 159 GQVKLADFGSASIVSPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 215 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + + P + S S R F+ C++ P++RPS++ LL H Sbjct: 216 ERKPPLFNMNAMSALYHIAQNDSPTLQSNEWSDSFRGFVDYCLQKIPQERPSSADLLRHD 275 Query: 359 FVNR 370 FV R Sbjct: 276 FVRR 279
>YP150_YEAST (Q12152) Putative serine/threonine-protein kinase YPL150W (EC| 2.7.11.1) Length = 901 Score = 87.4 bits (215), Expect = 3e-17 Identities = 44/120 (36%), Positives = 68/120 (56%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 NG+ KL DFG ++ L++ GT +MAPE++ + G DIWSLG + ++T Sbjct: 168 NGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLIT 227 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 LP+ D + + ++I EP I +ARD IS+ + NP +RPS S++L HPF+ Sbjct: 228 GYLPFDDDDEAKTKWKIVNEEPKYDAKVIPDDARDLISRLLAKNPGERPSLSQVLRHPFL 287
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 87.0 bits (214), Expect = 4e-17 Identities = 47/125 (37%), Positives = 72/125 (57%), Gaps = 3/125 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 + G VK+ DFG + T K + + GT YWMAPE+VN +K Y D+WSLG ++EM Sbjct: 517 SQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVN-QKGYDEKVDVWSLGIMLIEM 575 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLD 352 + + PY + + +ALY I P + P ++SK+ + F+ C++ N E R S KLL Sbjct: 576 IEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLT 635 Query: 353 HPFVN 367 F++ Sbjct: 636 FEFLS 640
>TAOK3_HUMAN (Q9H2K8) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen H Length = 898 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/124 (40%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y DIWSLG T +E+ Sbjct: 159 GQVKLADFGSASMASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELA 215 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + + P + S + R F+ C++ P++RP++++LL H Sbjct: 216 ERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHD 275 Query: 359 FVNR 370 FV R Sbjct: 276 FVRR 279
>MYO3A_MOUSE (Q8K3H5) Myosin IIIA (EC 2.7.11.1)| Length = 1613 Score = 86.7 bits (213), Expect = 6e-17 Identities = 50/128 (39%), Positives = 72/128 (56%), Gaps = 7/128 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKL-NVLKSCKGTVYWMAPEVVNPKK----TYGPAADIWSLGCTVL 172 G VKL DFG++ Q S + L + GT +WMAPEV+ ++ TY D WSLG T + Sbjct: 162 GGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAI 221 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 E+ P +L +AL++I + PP + P S E DFIS+C+ + E RP+ S L Sbjct: 222 ELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSDL 281 Query: 347 LDHPFVNR 370 L H F+ + Sbjct: 282 LKHKFITQ 289
>MYO3B_HUMAN (Q8WXR4) Myosin IIIB (EC 2.7.11.1)| Length = 1341 Score = 86.3 bits (212), Expect = 7e-17 Identities = 47/126 (37%), Positives = 72/126 (57%), Gaps = 7/126 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCK-GTVYWMAPEVVNPKKTYGPA----ADIWSLGCTVL 172 G VKL DFG++ Q + + ++ GT +WMAPEV+ ++ Y + D+WSLG T + Sbjct: 168 GGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAI 227 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 E+ P D+ + L++I + PP + P +E FISQC+ + E RPS + L Sbjct: 228 ELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHL 287 Query: 347 LDHPFV 364 LDHPF+ Sbjct: 288 LDHPFI 293
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 86.3 bits (212), Expect = 7e-17 Identities = 50/124 (40%), Positives = 69/124 (55%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y DIWSLG T +E+ Sbjct: 159 GQVKLADFGSASMASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELA 215 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEA-RDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + + P + S ++ R F+ C+ P++RP+A +LL H Sbjct: 216 ERKPPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERPAAVELLRHD 275 Query: 359 FVNR 370 F+ R Sbjct: 276 FIRR 279
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 86.3 bits (212), Expect = 7e-17 Identities = 50/135 (37%), Positives = 74/135 (54%), Gaps = 15/135 (11%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKT------------YGPAADIWSL 157 VK+ DFGLAK + +K+ GT+ ++APEV+ K T Y D+WS+ Sbjct: 335 VKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSM 394 Query: 158 GCTVLEMLTRQLPYPDLEWTQALYRIGKG---EPPAIPSAISKEARDFISQCVKPNPEDR 328 GC V +LT LP+ Q +IG+G E P IS+EARDFI ++ +P +R Sbjct: 395 GCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNR 454 Query: 329 PSASKLLDHPFVNRS 373 +A+K L+HP++ S Sbjct: 455 STAAKALNHPWIKMS 469
>TAOK2_MOUSE (Q6ZQ29) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1055 Score = 86.3 bits (212), Expect = 7e-17 Identities = 51/124 (41%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKL DFG A + N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E PA+ S S+ R+F+ C++ P+DRP++ LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHR 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 86.3 bits (212), Expect = 7e-17 Identities = 51/124 (41%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKL DFG A + N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E PA+ S S+ R+F+ C++ P+DRP++ LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHR 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 86.3 bits (212), Expect = 7e-17 Identities = 50/124 (40%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 ++G +KL+DFG Q SK + KS GT YWMAPEV++ + YG DIWSLG V+EM Sbjct: 578 SDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-RLPYGTEVDIWSLGIMVIEM 636 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLD 352 + + PY + QA+ RI PP + +S R F+ + P R +A +LL Sbjct: 637 IDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLG 696 Query: 353 HPFV 364 HPF+ Sbjct: 697 HPFL 700
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 86.3 bits (212), Expect = 7e-17 Identities = 50/124 (40%), Positives = 70/124 (56%), Gaps = 3/124 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 ++G +KL+DFG Q SK + KS GT YWMAPEV++ + YG DIWSLG V+EM Sbjct: 578 SDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-RLPYGTEVDIWSLGIMVIEM 636 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLD 352 + + PY + QA+ RI PP + +S R F+ + P R +A +LL Sbjct: 637 IDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLG 696 Query: 353 HPFV 364 HPF+ Sbjct: 697 HPFL 700
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 86.3 bits (212), Expect = 7e-17 Identities = 45/123 (36%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G++K+ DFG Q +++N + + GT YWMAPE+V+ +K YGP D+WSLG ++EML Sbjct: 1084 DGNIKITDFGFCAQINEINSKRITMVGTPYWMAPEIVS-RKEYGPKVDVWSLGIMIIEML 1142 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +ALY I P + P ++S + R F++ C++ + R A +LL Sbjct: 1143 EGEPPYLNETPLRALYLIATNGTPKLKDPESLSYDIRKFLAWCLQVDFNKRADADELLHD 1202 Query: 356 PFV 364 F+ Sbjct: 1203 NFI 1205
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 85.1 bits (209), Expect = 2e-16 Identities = 50/134 (37%), Positives = 71/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 2 ANGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A G+VK+ DFG AK T + N + GT YWMAPEVV K+ Y D+WSLG +EM Sbjct: 813 AYGNVKITDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKE-YDEKVDVWSLGIMTIEM 871 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLD 352 + + PY + E +ALY I P + P +S + F+S C+ + R S +LL+ Sbjct: 872 IEGEPPYLNEEPLKALYLIATNGTPKLKKPELLSNSIKKFLSICLCVDVRYRASTDELLE 931 Query: 353 HPFVNRSMRSIRSM 394 H F+ I + Sbjct: 932 HSFIQHKSGKIEEL 945
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 85.1 bits (209), Expect = 2e-16 Identities = 52/143 (36%), Positives = 73/143 (51%), Gaps = 3/143 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKL DFG A + N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITSIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S+ R+F+ C++ P+DRP++ LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPVLQSNHWSEYFRNFVDSCLQKIPQDRPTSDMLLKHR 279 Query: 359 FVNRSMRSIRSMRTYTRPNSSTR 427 F+ R M R + R Sbjct: 280 FLQRERPQTVIMELIQRTKDAVR 302
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 85.1 bits (209), Expect = 2e-16 Identities = 48/126 (38%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 N VKL DFG++ Q + + + GT YWMAPEV+ NP TY +D+WSLG T Sbjct: 164 NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITA 223 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 +EM P D+ +AL+ I + P + S SK+ + FI C+ N RP+ +L Sbjct: 224 IEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQL 283 Query: 347 LDHPFV 364 + HPF+ Sbjct: 284 MKHPFI 289
>TAOK3_XENLA (Q6DD27) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 896 Score = 85.1 bits (209), Expect = 2e-16 Identities = 50/124 (40%), Positives = 71/124 (57%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A ++S N S GT YWMAPEV+ + Y DIWSLG T +E+ Sbjct: 159 GQVKLADFGSASKSSPAN---SFVGTPYWMAPEVILAMDEGQYDGKIDIWSLGITCIELA 215 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S + + F+ C++ P++RP++ +LL H Sbjct: 216 ERKPPLFNMNAMSALYHIAQNESPTLQSNEWTDSFKGFVDYCLQKLPQERPASLELLRHD 275 Query: 359 FVNR 370 FV R Sbjct: 276 FVWR 279
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 85.1 bits (209), Expect = 2e-16 Identities = 48/126 (38%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 N VKL DFG++ Q + + + GT YWMAPEV+ NP TY +D+WSLG T Sbjct: 164 NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITA 223 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 +EM P D+ +AL+ I + P + S SK+ + FI C+ N RP+ +L Sbjct: 224 IEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQL 283 Query: 347 LDHPFV 364 + HPF+ Sbjct: 284 MKHPFI 289
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 85.1 bits (209), Expect = 2e-16 Identities = 50/126 (39%), Positives = 68/126 (53%), Gaps = 6/126 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 N VKL DFG++ Q + + + GT YWMAPEV+ NP TY +D+WS G T Sbjct: 164 NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITA 223 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 +EM P D+ +AL+ I + PP + S SK+ FI C+ N RPS +L Sbjct: 224 IEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQL 283 Query: 347 LDHPFV 364 L HPF+ Sbjct: 284 LKHPFI 289
>PAK4_HUMAN (O96013) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 591 Score = 84.7 bits (208), Expect = 2e-16 Identities = 48/126 (38%), Positives = 75/126 (59%), Gaps = 3/126 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G VKL+DFG Q SK + KS GT YWMAPE+++ + YGP DIWSLG V+EM+ Sbjct: 451 DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSLGIMVIEMV 509 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +A+ I PP + + +S + F+ + + +P R +A++LL H Sbjct: 510 DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKH 569 Query: 356 PFVNRS 373 PF+ ++ Sbjct: 570 PFLAKA 575
>M4K4_MOUSE (P97820) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1233 Score = 84.7 bits (208), Expect = 2e-16 Identities = 50/126 (39%), Positives = 68/126 (53%), Gaps = 6/126 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 N VKL DFG++ Q + + + GT YWMAPEV+ NP TY +D+WS G T Sbjct: 163 NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITA 222 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 +EM P D+ +AL+ I + PP + S SK+ FI C+ N RPS +L Sbjct: 223 IEMAEGGPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQL 282 Query: 347 LDHPFV 364 L HPF+ Sbjct: 283 LKHPFI 288
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 84.7 bits (208), Expect = 2e-16 Identities = 50/124 (40%), Positives = 69/124 (55%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKL DFG A + N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S+ R+F+ C++ P+DRP++ LL H Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHR 279 Query: 359 FVNR 370 FV R Sbjct: 280 FVLR 283
>TAO1A_XENLA (Q6NU21) Serine/threonine-protein kinase TAO1-A (EC 2.7.11.1)| (Thousand and one amino acid protein 1-A) Length = 1001 Score = 84.7 bits (208), Expect = 2e-16 Identities = 50/122 (40%), Positives = 69/122 (56%), Gaps = 3/122 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 163 GQVKLADFGSASIASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 219 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ P ++ ALY I + E P + S S R+F+ C++ P+DRP++ +LL + Sbjct: 220 ERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDFFRNFVDSCLQKIPQDRPTSDELLKNM 279 Query: 359 FV 364 FV Sbjct: 280 FV 281
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 84.3 bits (207), Expect = 3e-16 Identities = 53/135 (39%), Positives = 71/135 (52%), Gaps = 16/135 (11%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLN-----------VLKSCKGTVYWMAPEVV-NPKKTYGPAADIW 151 G +K +DFG A S L+ GT +MAPE++ KK A DIW Sbjct: 1173 GMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIW 1232 Query: 152 SLGCTVLEMLTRQLPYPDL--EWTQALYRIGKGEPPAIPS--AISKEARDFISQCVKPNP 319 SLGC +LEM+T P+ ++ EW +Y + P+IP IS ARDFI QC + +P Sbjct: 1233 SLGCVILEMMTGSTPWSEMDNEWA-IMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDP 1291 Query: 320 EDRPSASKLLDHPFV 364 E RP A LL HP++ Sbjct: 1292 EQRPRAVDLLTHPWI 1306
>PAK4_MOUSE (Q8BTW9) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 593 Score = 84.0 bits (206), Expect = 4e-16 Identities = 48/126 (38%), Positives = 74/126 (58%), Gaps = 3/126 (2%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G VKL+DFG Q SK + KS GT YWMAPE+++ + YGP DIWSLG V+EM+ Sbjct: 453 DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSLGVMVIEMV 511 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + +A+ I PP + + S + F+ + + +P R +A++LL H Sbjct: 512 DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKH 571 Query: 356 PFVNRS 373 PF+ ++ Sbjct: 572 PFLTKA 577
>NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC 2.7.11.1) (N-rich| kinase 1) Length = 652 Score = 83.6 bits (205), Expect = 5e-16 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 4/129 (3%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCK----GTVYWMAPEVVNPKKTYGPAADIWSLGCTVL 172 +G+VKL DFG+A ++LN+ + + GT YWMAPEV+ + Y ADIWSLG T Sbjct: 144 SGNVKLCDFGVA---AELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAY 200 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 E+ T P+ + +A+Y I PP + S ++FI+ C++ P+ R +S+LL Sbjct: 201 EIATGSPPHAKEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASCLQDVPQRRLDSSELLK 260 Query: 353 HPFVNRSMR 379 F+ + R Sbjct: 261 SKFIKQYSR 269
>TAOK3_PONPY (Q5R4F3) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 82.8 bits (203), Expect = 8e-16 Identities = 48/124 (38%), Positives = 69/124 (55%), Gaps = 3/124 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEML 181 G VKLADFG A S N S GT YWMAPEV+ + Y D+WSLG T +E+ Sbjct: 159 GQVKLADFGSASVASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA 215 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 R+ ++ ALY I + + P + S + R F+ C++ P++RP++++LL H Sbjct: 216 ERKPALFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHD 275 Query: 359 FVNR 370 FV R Sbjct: 276 FVRR 279
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 82.8 bits (203), Expect = 8e-16 Identities = 50/126 (39%), Positives = 67/126 (53%), Gaps = 6/126 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 N VKL DFG++ Q + + + GT YWMAPEV+ NP TY +DIWSLG T Sbjct: 164 NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITA 223 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 +EM P D+ +AL+ I + PP + S SK+ DFI C+ RP +L Sbjct: 224 IEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQL 283 Query: 347 LDHPFV 364 L PF+ Sbjct: 284 LKFPFI 289
>SPS1_YEAST (P08458) Sporulation-specific protein 1 (EC 2.7.11.1)| Length = 490 Score = 82.4 bits (202), Expect = 1e-15 Identities = 49/130 (37%), Positives = 69/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKT-YGPAADIWSLGCTVLEMLT 184 G VKL DFG++ + GT YWMAPEVV + Y ADIWSLG T E+L Sbjct: 153 GMVKLGDFGVSGHIRSTLKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLK 212 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P + + + + K +PP + S A+DF++ C+ P DRPSA LL FV Sbjct: 213 GLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFV 272 Query: 365 -NRSMRSIRS 391 N ++ +++S Sbjct: 273 KNITITNLKS 282
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 82.0 bits (201), Expect = 1e-15 Identities = 46/122 (37%), Positives = 73/122 (59%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 A+ +VKLADFG++ + + + GT+ WMAPE++ + +DIWSLG TV+EML Sbjct: 156 ADNTVKLADFGVSTIVNSSAL--TLAGTLNWMAPEILGNRGA-STLSDIWSLGATVVEML 212 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 T+ PY +L Y + + + PS+ S+ +DF+S+C N RP+A +LL H + Sbjct: 213 TKNPPYHNLTDANIYYAV-ENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVW 271 Query: 362 VN 367 +N Sbjct: 272 IN 273
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 82.0 bits (201), Expect = 1e-15 Identities = 50/126 (39%), Positives = 67/126 (53%), Gaps = 6/126 (4%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 N VKL DFG++ Q + + + GT YWMAPEV+ NP TY +DIWSLG T Sbjct: 164 NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITA 223 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 +EM P D+ +AL+ I + PP + S SK+ DFI C+ RP +L Sbjct: 224 IEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQL 283 Query: 347 LDHPFV 364 L PF+ Sbjct: 284 LKFPFI 289
>NIM1_NEUCR (P48479) G2-specific protein kinase nim-1 (EC 2.7.11.1)| Length = 779 Score = 82.0 bits (201), Expect = 1e-15 Identities = 47/135 (34%), Positives = 75/135 (55%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 + SVKL DFGL+K + + GT ++M+PE+ +K Y +DIWSLGC + E+ Sbjct: 172 DNSVKLGDFGLSKVMQSHDFASTYVGTPFYMSPEICAAEK-YTLKSDIWSLGCIIYELCA 230 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 R+ P+ Q + +I +G+ +PS S E I C++ NP+ RP + LL+ P V Sbjct: 231 REPPFNAKTHYQLVQKIKEGKIAPLPSVYSGELFATIKDCLRVNPDRRPDTATLLNLPIV 290 Query: 365 NRSMRSIRSMRTYTR 409 R MR + + ++R Sbjct: 291 -RLMRKEKEVVEFSR 304
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 81.6 bits (200), Expect = 2e-15 Identities = 50/126 (39%), Positives = 68/126 (53%), Gaps = 3/126 (2%) Frame = +2 Query: 5 NGSVKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G VK+ DFG AK T K + + GT YWMAPEVV ++ Y D+WSLG +EML Sbjct: 655 HGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEML 713 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 + PY + E +ALY I P + P +S E + F+S C+ + R S +LL H Sbjct: 714 EGEPPYLNEEPLKALYLIATNGTPKLKHPELLSLEIKRFLSVCLCVDVRYRASTEELLHH 773 Query: 356 PFVNRS 373 F S Sbjct: 774 SFFETS 779
>M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Length = 847 Score = 81.6 bits (200), Expect = 2e-15 Identities = 51/129 (39%), Positives = 72/129 (55%), Gaps = 7/129 (5%) Frame = +2 Query: 5 NGSVKLADFGLA-KQTSKLNVLKSCKGTVYWMAPEVVNPKKT--YGPAADIWSLGCTVLE 175 +G VKLADFG+A K T+ + KS GT YWMAPEV +K Y DIW++G T +E Sbjct: 151 HGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIE 210 Query: 176 MLTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRPSASK 343 + Q P DL +AL+ + K +PP + S +F+ + NP+ RP+A + Sbjct: 211 LGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER 270 Query: 344 LLDHPFVNR 370 LL H FV + Sbjct: 271 LLTHTFVGQ 279
>HEP_DROME (Q23977) Dual specificity mitogen-activated protein kinase kinase| hemipterous (EC 2.7.12.2) (MAPKK) Length = 1178 Score = 81.3 bits (199), Expect = 2e-15 Identities = 44/125 (35%), Positives = 69/125 (55%), Gaps = 6/125 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKT-YGPAADIWSLGCTVLEMLT 184 G++KL DFG++ + G +MAPE ++PKK Y AD+WSLG T++E+ T Sbjct: 332 GNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELAT 391 Query: 185 RQLPYPDLEWT-QALYRIGKGEPPAIPSA----ISKEARDFISQCVKPNPEDRPSASKLL 349 + PY + L ++ EPP +P S++ RDF+ +C+ N +DRP +LL Sbjct: 392 ARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELL 451 Query: 350 DHPFV 364 PF+ Sbjct: 452 AQPFI 456
>M4K5_HUMAN (Q9Y4K4) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS) Length = 846 Score = 81.3 bits (199), Expect = 2e-15 Identities = 51/127 (40%), Positives = 71/127 (55%), Gaps = 7/127 (5%) Frame = +2 Query: 5 NGSVKLADFGLA-KQTSKLNVLKSCKGTVYWMAPEVVNPKKT--YGPAADIWSLGCTVLE 175 +G VKLADFG+A K T+ + KS GT YWMAPEV +K Y DIW++G T +E Sbjct: 151 HGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIE 210 Query: 176 MLTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRPSASK 343 + Q P DL +AL+ + K +PP + S +F+ + NP+ RP+A + Sbjct: 211 LGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER 270 Query: 344 LLDHPFV 364 LL H FV Sbjct: 271 LLTHTFV 277
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 80.1 bits (196), Expect = 5e-15 Identities = 46/138 (33%), Positives = 73/138 (52%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y ADIWS G T Sbjct: 157 DGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGIT 216 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP++ + + K R IS C++ +P Sbjct: 217 AIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDP 276 Query: 320 EDRPSASKLLDHPFVNRS 373 E RP+A++LL H F ++ Sbjct: 277 EKRPTAAELLRHKFFQKA 294
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 80.1 bits (196), Expect = 5e-15 Identities = 46/138 (33%), Positives = 73/138 (52%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y ADIWS G T Sbjct: 157 DGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGIT 216 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP++ + + K R IS C++ +P Sbjct: 217 AIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDP 276 Query: 320 EDRPSASKLLDHPFVNRS 373 E RP+A++LL H F ++ Sbjct: 277 EKRPTAAELLRHKFFQKA 294
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 80.1 bits (196), Expect = 5e-15 Identities = 46/138 (33%), Positives = 73/138 (52%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y ADIWS G T Sbjct: 157 DGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGIT 216 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP++ + + K R IS C++ +P Sbjct: 217 AIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDP 276 Query: 320 EDRPSASKLLDHPFVNRS 373 E RP+A++LL H F ++ Sbjct: 277 EKRPTAAELLRHKFFQKA 294
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 80.1 bits (196), Expect = 5e-15 Identities = 46/138 (33%), Positives = 73/138 (52%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y ADIWS G T Sbjct: 157 DGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGIT 216 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP++ + + K R IS C++ +P Sbjct: 217 AIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDP 276 Query: 320 EDRPSASKLLDHPFVNRS 373 E RP+A++LL H F ++ Sbjct: 277 EKRPTAAELLRHKFFQKA 294
>NEK1_HUMAN (Q96PY6) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) (NY-REN-55 antigen) Length = 1258 Score = 79.3 bits (194), Expect = 9e-15 Identities = 41/130 (31%), Positives = 71/130 (54%), Gaps = 1/130 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G+V+L DFG+A+ S + + ++C GT Y+++PE+ K Y +DIW+LGC + E+ Sbjct: 139 DGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICE-NKPYNNKSDIWALGCVLYELC 197 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 T + + + +I G P + S + R +SQ K NP DRPS + +L+ F Sbjct: 198 TLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGF 257 Query: 362 VNRSMRSIRS 391 + + + S Sbjct: 258 IAKRIEKFLS 267
>NEK1_MOUSE (P51954) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) Length = 1203 Score = 79.3 bits (194), Expect = 9e-15 Identities = 41/130 (31%), Positives = 71/130 (54%), Gaps = 1/130 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +G+V+L DFG+A+ S + + ++C GT Y+++PE+ K Y +DIW+LGC + E+ Sbjct: 139 DGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICE-NKPYNNKSDIWALGCVLYELC 197 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 T + + + +I G P + S + R +SQ K NP DRPS + +L+ F Sbjct: 198 TLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGF 257 Query: 362 VNRSMRSIRS 391 + + + S Sbjct: 258 IAKRIEKFLS 267
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 79.0 bits (193), Expect = 1e-14 Identities = 48/168 (28%), Positives = 88/168 (52%), Gaps = 1/168 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N +K+ADFG+A +LK+ G+ ++ +PE+V + +G +D+WS G + +LT Sbjct: 251 NRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLT 310 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 LP+ D + L ++ G+ +PS +S EARD IS+ + +PE R + ++L HP + Sbjct: 311 GHLPFNDDNIKKLLLKVQSGK-YQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLI 369 Query: 365 NR-SMRSIRSMRTYTRPNSSTRGTSG*CCGQL*HIGRIILVLTNHAEL 505 + + + R ++ RG S L ++ I+ L + E+ Sbjct: 370 KKYDDLPVNKVLRKMRKDNMARGKSNSDLHLLNNVSPSIVTLHSKGEI 417
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 78.2 bits (191), Expect = 2e-14 Identities = 47/121 (38%), Positives = 67/121 (55%), Gaps = 3/121 (2%) Frame = +2 Query: 14 VKLADFGL-AKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 VK+ DFG A+ T K + + GT YWMAPEVV ++ Y D+WSLG +EML + Sbjct: 707 VKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQRE-YDEKIDVWSLGIMTIEMLEGE 765 Query: 191 LPYPDLEWTQALYRIGKGEPPAI--PSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 PY + + +ALY I P + P ++S E + F+S C+ + R S +LL H F Sbjct: 766 PPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFF 825 Query: 365 N 367 N Sbjct: 826 N 826
>NIMA_EMENI (P11837) G2-specific protein kinase nimA (EC 2.7.11.1) (Never in| mitosis) Length = 699 Score = 78.2 bits (191), Expect = 2e-14 Identities = 38/128 (29%), Positives = 72/128 (56%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 ++ +VKL DFGL+K + + GT ++M+PE+ +K Y +DIW++GC + E+ Sbjct: 176 SDNTVKLGDFGLSKLMHSHDFASTYVGTPFYMSPEICAAEK-YTLRSDIWAVGCIMYELC 234 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 R+ P+ Q + +I +G+ +P S E ++ I+ C++ NP+ RP + L++ P Sbjct: 235 QREPPFNARTHIQLVQKIREGKFAPLPDFYSSELKNVIASCLRVNPDHRPDTATLINTPV 294 Query: 362 VNRSMRSI 385 + R + Sbjct: 295 IRLMRREV 302
>PBS2_YEAST (P08018) MAP kinase kinase PBS2 (EC 2.7.12.2) (Polymyxin B| resistance protein 2) (Suppressor of fluoride sensitivity 4) Length = 668 Score = 77.8 bits (190), Expect = 3e-14 Identities = 49/127 (38%), Positives = 74/127 (58%), Gaps = 8/127 (6%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV---NPKK-TYGPAADIWSLGCTVLE 175 G+VKL DFG++ ++ K+ G +MAPE + NP + TY +DIWSLG ++LE Sbjct: 498 GTVKLCDFGVSGNLVA-SLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILE 556 Query: 176 MLTRQLPYPDLEWTQA---LYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASK 343 M + PYP + L I G PP +PS S +A+DF+S C++ PE RP+ + Sbjct: 557 MALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAA 616 Query: 344 LLDHPFV 364 L +HP++ Sbjct: 617 LTEHPWL 623
>M4K2_HUMAN (Q12851) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-pro Length = 819 Score = 77.4 bits (189), Expect = 3e-14 Identities = 48/130 (36%), Positives = 70/130 (53%), Gaps = 7/130 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLEM 178 G VKLADFG++ + T+ + +S GT YWMAPEV V K Y D+W+LG T +E+ Sbjct: 147 GDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIEL 206 Query: 179 LTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRPSASKL 346 Q P L +AL + K +PP + ++ F+ + NP+ RP+A KL Sbjct: 207 GELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKL 266 Query: 347 LDHPFVNRSM 376 L HPF + + Sbjct: 267 LQHPFTTQQL 276
>MP2K2_XENLA (Q07192) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (MAPK-ERK kinase 2) (Fragment) Length = 446 Score = 77.4 bits (189), Expect = 3e-14 Identities = 43/130 (33%), Positives = 71/130 (54%), Gaps = 10/130 (7%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNP---KKTYGPAADIWSLGCTVLE 175 NG++KL DFG++ Q G +MAPE ++P ++ Y +D+WSLG T+ E Sbjct: 287 NGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYE 346 Query: 176 MLTRQLPYPDLEWTQA---LYRIGKGEPPAIPSAISKE----ARDFISQCVKPNPEDRPS 334 + T + PYP +W L ++ KG+PP + ++ +E F++QC+ + RP Sbjct: 347 LATGRFPYP--KWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFTSFVNQCLTKDESKRPK 404 Query: 335 ASKLLDHPFV 364 +LL HPF+ Sbjct: 405 YKELLKHPFI 414
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 77.0 bits (188), Expect = 4e-14 Identities = 43/143 (30%), Positives = 75/143 (52%), Gaps = 2/143 (1%) Frame = +2 Query: 14 VKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +K+ D G+A+ ++ + GT Y+M+PE+ + K Y +D+W+LGC V EM T + Sbjct: 145 IKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS-NKPYNYKSDVWALGCCVYEMATLK 203 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVNR 370 + + +YRI +G+ PA+P S E + I + PE+RPS +L P++ R Sbjct: 204 HAFNAKDMNSLVYRIIEGKLPAMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKR 263 Query: 371 SMR-SIRSMRTYTRPNSSTRGTS 436 + + + + T N+ G S Sbjct: 264 QISFFLEATKIKTSKNNIKNGDS 286
>MP2K5_RAT (Q62862) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 448 Score = 77.0 bits (188), Expect = 4e-14 Identities = 43/128 (33%), Positives = 74/128 (57%), Gaps = 8/128 (6%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 +G VKL DFG++ Q ++ K+ GT +MAPE ++ ++ YG +D+WSLG + +E+ Sbjct: 294 SGQVKLCDFGVSTQLVN-SIAKTYVGTNAYMAPERISGEQ-YGIHSDVWSLGISFMELAL 351 Query: 185 RQLPYPDLEWTQA-------LYRIGKGEPPAIP-SAISKEARDFISQCVKPNPEDRPSAS 340 + PYP ++ Q L I + P +P S+ FI+QC++ P++RP+ Sbjct: 352 GRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPE 411 Query: 341 KLLDHPFV 364 +L+ HPF+ Sbjct: 412 ELMGHPFI 419
>MIG15_CAEEL (Q23356) Serine/threonine-protein kinase mig-15 (EC 2.7.11.1)| (Abnormal cell migration protein 15) Length = 1096 Score = 76.6 bits (187), Expect = 6e-14 Identities = 46/127 (36%), Positives = 66/127 (51%), Gaps = 7/127 (5%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVV----NPKKTYGPAADIWSLGCTV 169 + VKL DFG++ Q K + + GT YWMAPEV+ +P+ TY +D+WSLG T Sbjct: 162 SAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITA 221 Query: 170 LEMLTRQLPYPDLEWTQALYRIGKGEPPAIP--SAISKEARDFISQCVKPNPEDRPSASK 343 LEM P D+ +AL+ I + PP + +K+ FI + + RP Sbjct: 222 LEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGA 281 Query: 344 LLDHPFV 364 LL HPF+ Sbjct: 282 LLRHPFI 288
>MP2K5_MOUSE (Q9WVS7) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 448 Score = 76.6 bits (187), Expect = 6e-14 Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 8/127 (6%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G VKL DFG++ Q ++ K+ GT +MAPE ++ ++ YG +D+WSLG + +E+ Sbjct: 295 GQVKLCDFGVSTQLVN-SIAKTYVGTNAYMAPERISGEQ-YGIHSDVWSLGISFMELALG 352 Query: 188 QLPYPDLEWTQA-------LYRIGKGEPPAIP-SAISKEARDFISQCVKPNPEDRPSASK 343 + PYP ++ Q L I + P +P S+ FI+QC++ P++RP+ + Sbjct: 353 RFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEE 412 Query: 344 LLDHPFV 364 L+ HPF+ Sbjct: 413 LMGHPFI 419
>MP2K7_HUMAN (O14733) Dual specificity mitogen-activated protein kinase kinase 7| (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Length = 419 Score = 76.3 bits (186), Expect = 8e-14 Identities = 41/128 (32%), Positives = 68/128 (53%), Gaps = 7/128 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNP----KKTYGPAADIWSLGCTVLE 175 G +KL DFG++ + G +MAPE ++P K Y AD+WSLG +++E Sbjct: 255 GQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVE 314 Query: 176 MLTRQLPYPDLEWT-QALYRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKL 346 + T Q PY + + + L ++ + EPP +P S + + F+ C+ + RP +KL Sbjct: 315 LATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKL 374 Query: 347 LDHPFVNR 370 L+H F+ R Sbjct: 375 LEHSFIKR 382
>SULU_CAEEL (P46549) Serine/threonine-protein kinase SULU (EC 2.7.11.1)| (Protein kinase 18) Length = 982 Score = 76.3 bits (186), Expect = 8e-14 Identities = 48/132 (36%), Positives = 71/132 (53%), Gaps = 9/132 (6%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEMLTR 187 VKLADFG A S ++ ++ GT ++MAPEV+ + Y ADIWSLG T +E+ R Sbjct: 167 VKLADFGSA---SLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAER 223 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARD-------FISQCVKPNPEDRPSASKL 346 + P + ALY I + +PP + + E + FI +C++ E+R SA + Sbjct: 224 RPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEEC 283 Query: 347 LDHPFVNRSMRS 382 HPF+ RS S Sbjct: 284 FRHPFIQRSRPS 295
>M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein) Length = 821 Score = 75.9 bits (185), Expect = 1e-13 Identities = 47/130 (36%), Positives = 70/130 (53%), Gaps = 7/130 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLEM 178 G VKLADFG++ + T+ + +S GT YWMAPEV V K Y D+W+LG T +E+ Sbjct: 148 GDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIEL 207 Query: 179 LTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRPSASKL 346 Q P L +AL + K +PP + ++ F+ + NP+ RP+A +L Sbjct: 208 GELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERL 267 Query: 347 LDHPFVNRSM 376 L HPF + + Sbjct: 268 LQHPFTTQHL 277
>CDK7_DICDI (P54685) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (MO15 homolog) Length = 362 Score = 75.1 bits (183), Expect = 2e-13 Identities = 52/153 (33%), Positives = 76/153 (49%), Gaps = 28/153 (18%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKG-TVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 NG +KLADFGLA+Q N + S + T+++ APE++ K+YGP+ DIWS+GC E++ Sbjct: 141 NGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELM 200 Query: 182 TRQLPYPDLEWTQALYRI--GKGEP--------------------PAIP-----SAISKE 280 R P L +I G P PA P +A S E Sbjct: 201 LRTPYLPGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDHPATPFKQLFTAASDE 260 Query: 281 ARDFISQCVKPNPEDRPSASKLLDHPFVNRSMR 379 A D IS+ + NP +R SA+ L+HP+ ++ Sbjct: 261 AIDLISKMLLFNPSNRISAADALNHPYFTSGVK 293
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/125 (36%), Positives = 68/125 (54%), Gaps = 9/125 (7%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNV-LKSCKGTVYWMAPEVVNPKKT-----YGPAADIWSLGCTVLE 175 +K++DFGLAK L++ GT+ ++APEV+ K Y DIWSLGC + Sbjct: 308 LKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYV 367 Query: 176 MLTRQLPYPDLEWTQALYRIGKGEPPAIP---SAISKEARDFISQCVKPNPEDRPSASKL 346 MLT +P+ + + I KG P P + IS+E D I++ ++ NPE R S S+ Sbjct: 368 MLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKRISESEA 427 Query: 347 LDHPF 361 L HP+ Sbjct: 428 LQHPW 432
>CDR1_SCHPO (P07334) Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein| kinase nim1) Length = 593 Score = 74.7 bits (182), Expect = 2e-13 Identities = 42/136 (30%), Positives = 76/136 (55%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 +K+ADFG+A + L++ G+++++APE+V+ K G AD+WS G + +L+ +L Sbjct: 143 IKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKL 202 Query: 194 PYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVNRS 373 P+ + T +Y + +PS+IS A+D + + + NP R + ++ HPF+ Sbjct: 203 PFGG-QNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFL-MG 260 Query: 374 MRSIRSMRTYTRPNSS 421 S+ SM + T P S Sbjct: 261 CTSLSSMDSTTPPTPS 276
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 74.3 bits (181), Expect = 3e-13 Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 VK++DFG +K+ S + S GTV WMAPEV+ + DIWS G + E+LT ++ Sbjct: 250 VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEI 308 Query: 194 PYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 PY D++ + ++ +G +PS+ + + QC P +RPS ++L H Sbjct: 309 PYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 363
>M4K1_MOUSE (P70218) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK) Length = 827 Score = 74.3 bits (181), Expect = 3e-13 Identities = 49/128 (38%), Positives = 68/128 (53%), Gaps = 7/128 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLEM 178 G VKLADFG++ Q + S GT YWMAPEV V K Y DIWSLG T +E+ Sbjct: 149 GEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIEL 208 Query: 179 LTRQLPYPDLEWTQALYRIGKG--EPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 Q P D+ + L+ + K +PP + S S +F+ + N + RPSA+K+ Sbjct: 209 AELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKM 268 Query: 347 LDHPFVNR 370 L H V++ Sbjct: 269 LSHQLVSQ 276
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 74.3 bits (181), Expect = 3e-13 Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 VK++DFG +K+ S + S GTV WMAPEV+ + DIWS G + E+LT ++ Sbjct: 283 VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEI 341 Query: 194 PYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 PY D++ + ++ +G +PS+ + + QC P +RPS ++L H Sbjct: 342 PYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 396
>MP2K6_HUMAN (P52564) Dual specificity mitogen-activated protein kinase kinase 6| (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3) Length = 334 Score = 73.9 bits (180), Expect = 4e-13 Identities = 46/127 (36%), Positives = 68/127 (53%), Gaps = 7/127 (5%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPK---KTYGPAADIWSLGCTVL 172 A G VK+ DFG++ G +MAPE +NP+ K Y +DIWSLG T++ Sbjct: 189 ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 Query: 173 EMLTRQLPYPDLEWT---QALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSAS 340 E+ + PY W Q L ++ + P +P+ S E DF SQC+K N ++RP+ Sbjct: 249 ELAILRFPYDS--WGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYP 306 Query: 341 KLLDHPF 361 +L+ HPF Sbjct: 307 ELMQHPF 313
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 73.9 bits (180), Expect = 4e-13 Identities = 43/124 (34%), Positives = 73/124 (58%), Gaps = 1/124 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N ++K+ADFGLA Q + + + GT +++PE+ + +G +DIWSLGC +L Sbjct: 147 NMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIAT-RSAHGLESDIWSLGCMFYTLL 205 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + P+ L ++ + +P+ +S+EA+D I Q ++ NP DR S S +LDHPF Sbjct: 206 IGRPPFDTDTVKNTLNKVVLADYE-MPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPF 264 Query: 362 VNRS 373 ++R+ Sbjct: 265 MSRN 268
>NEK3_HUMAN (P51956) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) (HSPK 36) Length = 506 Score = 73.9 bits (180), Expect = 4e-13 Identities = 44/123 (35%), Positives = 63/123 (51%), Gaps = 1/123 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 NG VKL DFG A+ S + + GT Y++ PE+ Y +DIWSLGC + E+ Sbjct: 138 NGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWE-NLPYNNKSDIWSLGCILYELC 196 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 T + P+ W + ++ +G +PS S E + + Q K NP RPSA+ LL Sbjct: 197 TLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGI 256 Query: 362 VNR 370 V R Sbjct: 257 VAR 259
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 73.9 bits (180), Expect = 4e-13 Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 VK++DFG +K+ S + S GTV WMAPEV+ + DIWS G + E+LT ++ Sbjct: 283 VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEI 341 Query: 194 PYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 PY D++ + ++ +G +PS+ + + QC P +RPS ++L H Sbjct: 342 PYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQILLH 396
>MP2K3_MOUSE (O09110) Dual specificity mitogen-activated protein kinase kinase 3| (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) Length = 347 Score = 73.6 bits (179), Expect = 5e-13 Identities = 45/125 (36%), Positives = 67/125 (53%), Gaps = 7/125 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPK---KTYGPAADIWSLGCTVLEM 178 G VK+ DFG++ G +MAPE +NP+ K Y +D+WSLG T++EM Sbjct: 202 GHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEM 261 Query: 179 LTRQLPYPDLEWT---QALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 + PY W Q L ++ + P +P+ S E DF SQC++ NP +R S +L Sbjct: 262 AILRFPYES--WGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLEL 319 Query: 347 LDHPF 361 ++HPF Sbjct: 320 MEHPF 324
>MP2K4_HUMAN (P45985) Dual specificity mitogen-activated protein kinase kinase 4| (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) Length = 399 Score = 73.2 bits (178), Expect = 6e-13 Identities = 41/130 (31%), Positives = 71/130 (54%), Gaps = 10/130 (7%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNP---KKTYGPAADIWSLGCTVLE 175 +G++KL DFG++ Q G +MAPE ++P ++ Y +D+WSLG T+ E Sbjct: 240 SGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYE 299 Query: 176 MLTRQLPYPDLEWTQA---LYRIGKGEPPAIPSAISKEAR----DFISQCVKPNPEDRPS 334 + T + PYP +W L ++ KG+PP + ++ +E +F++ C+ + RP Sbjct: 300 LATGRFPYP--KWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPK 357 Query: 335 ASKLLDHPFV 364 +LL HPF+ Sbjct: 358 YKELLKHPFI 367
>MP2K4_MOUSE (P47809) Dual specificity mitogen-activated protein kinase kinase 4| (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SE Length = 397 Score = 73.2 bits (178), Expect = 6e-13 Identities = 41/130 (31%), Positives = 71/130 (54%), Gaps = 10/130 (7%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNP---KKTYGPAADIWSLGCTVLE 175 +G++KL DFG++ Q G +MAPE ++P ++ Y +D+WSLG T+ E Sbjct: 238 SGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYE 297 Query: 176 MLTRQLPYPDLEWTQA---LYRIGKGEPPAIPSAISKEAR----DFISQCVKPNPEDRPS 334 + T + PYP +W L ++ KG+PP + ++ +E +F++ C+ + RP Sbjct: 298 LATGRFPYP--KWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPK 355 Query: 335 ASKLLDHPFV 364 +LL HPF+ Sbjct: 356 YKELLKHPFI 365
>MP2K6_MOUSE (P70236) Dual specificity mitogen-activated protein kinase kinase 6| (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3) Length = 334 Score = 72.4 bits (176), Expect = 1e-12 Identities = 44/125 (35%), Positives = 67/125 (53%), Gaps = 7/125 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPK---KTYGPAADIWSLGCTVLEM 178 G VK+ DFG++ G +MAPE +NP+ K Y +DIWSLG T++E+ Sbjct: 191 GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 Query: 179 LTRQLPYPDLEWT---QALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 + PY W Q L ++ + P +P+ S + DF SQC+K N ++RP+ +L Sbjct: 251 AILRFPYDS--WGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPEL 308 Query: 347 LDHPF 361 + HPF Sbjct: 309 MQHPF 313
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 72.4 bits (176), Expect = 1e-12 Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y AD+WS G T Sbjct: 215 DGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGIT 274 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP + + + K R +S C++ +P Sbjct: 275 AIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDP 334 Query: 320 EDRPSASKLLDHPFVNRS 373 RP+A++LL F ++ Sbjct: 335 SKRPTAAELLKCKFFQKA 352
>MP2K3_HUMAN (P46734) Dual specificity mitogen-activated protein kinase kinase 3| (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) Length = 347 Score = 72.4 bits (176), Expect = 1e-12 Identities = 44/125 (35%), Positives = 67/125 (53%), Gaps = 7/125 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPK---KTYGPAADIWSLGCTVLEM 178 G VK+ DFG++ G +MAPE +NP+ K Y +D+WSLG T++EM Sbjct: 202 GHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEM 261 Query: 179 LTRQLPYPDLEWT---QALYRIGKGEPPAIPS-AISKEARDFISQCVKPNPEDRPSASKL 346 + PY W Q L ++ + P +P+ S E DF +QC++ NP +R S +L Sbjct: 262 AILRFPYES--WGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLEL 319 Query: 347 LDHPF 361 ++HPF Sbjct: 320 MEHPF 324
>M4K1_HUMAN (Q92918) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) Length = 833 Score = 72.4 bits (176), Expect = 1e-12 Identities = 48/128 (37%), Positives = 68/128 (53%), Gaps = 7/128 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLEM 178 G V+LADFG++ Q + S GT YWMAPEV V K Y DIWSLG T +E+ Sbjct: 149 GEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIEL 208 Query: 179 LTRQLPYPDLEWTQALYRIGKG--EPPAI--PSAISKEARDFISQCVKPNPEDRPSASKL 346 Q P D+ + L+ + K +PP + S +FI + +P+ RPSA+K+ Sbjct: 209 AELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKM 268 Query: 347 LDHPFVNR 370 L H V++ Sbjct: 269 LSHQLVSQ 276
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 72.4 bits (176), Expect = 1e-12 Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y AD+WS G T Sbjct: 205 DGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGIT 264 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP + + + K R +S C++ +P Sbjct: 265 AIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDP 324 Query: 320 EDRPSASKLLDHPFVNRS 373 RP+A++LL F ++ Sbjct: 325 SKRPTAAELLKCKFFQKA 342
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 72.4 bits (176), Expect = 1e-12 Identities = 38/118 (32%), Positives = 63/118 (53%), Gaps = 1/118 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCK-GTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +K+ D G+A+ + S GT Y+M+PE+ + K Y +D+W+LGC V EM T + Sbjct: 145 IKVGDLGIARVLENHGDMASTLIGTPYYMSPELFS-NKPYNYKSDVWALGCCVYEMATLK 203 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + + +YRI +G+ P +P S E + I + PE+RPS +L P++ Sbjct: 204 HAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYI 261
>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8) Length = 979 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 8/145 (5%) Frame = +2 Query: 14 VKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +KL D+GLAK+ S+ ++ ++ GT Y+M+PE+ K Y +DIW++GC + E+LT + Sbjct: 190 IKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVK-YNFKSDIWAVGCVIFELLTLK 248 Query: 191 LPYPDLEWTQALYRIGKG--EPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + +I +G S S E + C+ +PE RP+A +LLD P + Sbjct: 249 RTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLL 308 Query: 365 NRSMRSIRSMRTY-----TRPNSST 424 + R + T RP SST Sbjct: 309 RKRRREMEEKVTLLNAPTKRPRSST 333
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 72.4 bits (176), Expect = 1e-12 Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 15/138 (10%) Frame = +2 Query: 5 NGSVKLADFGLAK------QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCT 166 +GSV++ADFG++ ++ V K+ GT WMAPEV+ + Y AD+WS G T Sbjct: 212 DGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGIT 271 Query: 167 VLEMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAI---------SKEARDFISQCVKPNP 319 +E+ T PY + L + +PP + + + K R +S C++ +P Sbjct: 272 AIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDP 331 Query: 320 EDRPSASKLLDHPFVNRS 373 RP+A++LL F ++ Sbjct: 332 SKRPTAAELLKCKFFQKA 349
>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase) Length = 944 Score = 71.6 bits (174), Expect = 2e-12 Identities = 44/145 (30%), Positives = 83/145 (57%), Gaps = 8/145 (5%) Frame = +2 Query: 14 VKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +KL D+GLAKQ +S+ ++ ++C GT+Y+M+PE+ K Y +DIW++GC + E+LT Sbjct: 172 IKLGDYGLAKQLSSEYSMAETCVGTLYYMSPEICQGVK-YSFKSDIWAVGCVLYELLTLT 230 Query: 191 LPYPDLEWTQALYRIGKGE-PPAIPSAI-SKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + +I +G + + + ++E + + C++ +PE RP+A ++L+ P + Sbjct: 231 RTFDATNPLNLCVKIVQGNWAVGLDNTVYTQELIEVVHACLEQDPEKRPTADEILERPIL 290 Query: 365 N---RSMRSIRSM--RTYTRPNSST 424 + R M SM R+ +P + T Sbjct: 291 SWRRRDMEEKVSMLNRSNKKPRTGT 315
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 71.6 bits (174), Expect = 2e-12 Identities = 42/124 (33%), Positives = 71/124 (57%), Gaps = 1/124 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N ++K+ADFGLA Q + + GT +++PE+ + +G +D+WSLGC +L Sbjct: 147 NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIAT-RSAHGLESDVWSLGCMFYTLL 205 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + P+ L ++ + +P+ +S EA+D I Q ++ NP DR S S +LDHPF Sbjct: 206 IGRPPFDTDTVKNTLNKVVLADYE-MPTFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPF 264 Query: 362 VNRS 373 ++R+ Sbjct: 265 MSRN 268
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/153 (31%), Positives = 86/153 (56%), Gaps = 12/153 (7%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 ++K+ADFG+A ++ +L++ G+ ++ APE+V+ G A+D+WS G + +LT + Sbjct: 169 NIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGR 228 Query: 191 LPYPDLEWT--QALYRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLDHP 358 LP+ + + L ++ KGE +PS IS+EA+D I + + +PE R +L HP Sbjct: 229 LPFDEEDGNIRTLLLKVQKGE-FEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHP 287 Query: 359 FVNR--SMRSIRSMR------TYTRPNSSTRGT 433 + + S+R +S+R TY P S + + Sbjct: 288 LLQKYPSIRDSKSIRGLPREDTYLTPLSESNSS 320
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 71.2 bits (173), Expect = 2e-12 Identities = 41/108 (37%), Positives = 58/108 (53%), Gaps = 6/108 (5%) Frame = +2 Query: 59 NVLKSCKGTVYWMAPEVVNPKKTYGP--AADIWSLGCTVLEMLTRQLPYPDL--EWTQAL 226 N L GT +MAPE + T G A D+WSLGC VLEM+T + P+ +L EW + Sbjct: 1452 NALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNEWA-IM 1510 Query: 227 YRIGKGEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 Y + G P P+ +S F+ +C+ NP R SA +LL P++ Sbjct: 1511 YHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELLMDPWI 1558
>M3K1_RAT (Q62925) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/124 (34%), Positives = 68/124 (54%), Gaps = 9/124 (7%) Frame = +2 Query: 14 VKLADFGLA-----KQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 +++ADFG A K T GT+ +MAPEV+ ++ YG + D+WS+GC ++EM Sbjct: 1365 LRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQ-YGRSCDVWSVGCAIIEM 1423 Query: 179 LTRQLPYPDLEWTQALYRIGK----GEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 + P+ + + L I K P+IPS +S RD +C++ P+DRP + +L Sbjct: 1424 ACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSREL 1483 Query: 347 LDHP 358 L HP Sbjct: 1484 LKHP 1487
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/124 (34%), Positives = 68/124 (54%), Gaps = 9/124 (7%) Frame = +2 Query: 14 VKLADFGLA-----KQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 +++ADFG A K T GT+ +MAPEV+ ++ YG + D+WS+GC ++EM Sbjct: 1365 LRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQ-YGRSCDVWSVGCAIIEM 1423 Query: 179 LTRQLPYPDLEWTQALYRIGK----GEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 + P+ + + L I K P+IPS +S RD +C++ P+DRP + +L Sbjct: 1424 ACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVAVRCLELQPQDRPPSREL 1483 Query: 347 LDHP 358 L HP Sbjct: 1484 LKHP 1487
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/124 (34%), Positives = 68/124 (54%), Gaps = 9/124 (7%) Frame = +2 Query: 14 VKLADFGLA-----KQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 +++ADFG A K T GT+ +MAPEV+ ++ YG + D+WS+GC ++EM Sbjct: 1367 LRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQ-YGRSCDVWSVGCAIIEM 1425 Query: 179 LTRQLPYPDLEWTQALYRIGK----GEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 + P+ + + L I K P+IPS +S RD +C++ P+DRP + +L Sbjct: 1426 ACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSREL 1485 Query: 347 LDHP 358 L HP Sbjct: 1486 LKHP 1489
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 4/121 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A G VKL D GL + +SK S GT Y+M+PE ++ + Y +DIWSLGC + EM Sbjct: 171 ATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEM 229 Query: 179 LTRQLPY--PDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRPSASKLL 349 Q P+ + +I + + P +PS S+E R ++ C+ P+PE RP + + Sbjct: 230 AALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVY 289 Query: 350 D 352 D Sbjct: 290 D 290
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/121 (38%), Positives = 67/121 (55%), Gaps = 1/121 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N KL DFGLA+ T +VL S KGT +MAPE++ ++ Y AD+WSLGC E + Sbjct: 136 NMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELL-AEQPYDHHADMWSLGCIAYESM 194 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 Q P+ L ++ K E PS ++ E R F+ ++ +P R S ++LL HPF Sbjct: 195 AGQPPFCASSILH-LVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPF 253 Query: 362 V 364 V Sbjct: 254 V 254
>NEK3_MOUSE (Q9R0A5) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) Length = 511 Score = 70.5 bits (171), Expect = 4e-12 Identities = 40/116 (34%), Positives = 62/116 (53%), Gaps = 1/116 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 NG VKL DFG A+ +S + + GT Y++ PE+ Y +DIWSLGC + E+ Sbjct: 136 NGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWE-NLPYNNKSDIWSLGCILYELC 194 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 + P+ W + +I +G +P+ S + + + Q +K NP RPSA+ LL Sbjct: 195 ALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLL 250
>KIN3_YEAST (P22209) Serine/threonine-protein kinase KIN3 (EC 2.7.11.1)| Length = 435 Score = 70.1 bits (170), Expect = 5e-12 Identities = 41/129 (31%), Positives = 65/129 (50%), Gaps = 1/129 (0%) Frame = +2 Query: 14 VKLADFGLAKQT-SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 VKL DFGLAK + + + GT Y+M+PEV+ + Y P +DIWSLGC + EM + Sbjct: 227 VKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQP-YSPLSDIWSLGCVIFEMCSLH 285 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVNR 370 P+ + + +I G+ +P S+ I + N RPS +LL + Sbjct: 286 PPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMIDVNLRTRPSTFELLQDIQIRT 345 Query: 371 SMRSIRSMR 397 + +S++ R Sbjct: 346 ARKSLQLER 354
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 70.1 bits (170), Expect = 5e-12 Identities = 34/122 (27%), Positives = 70/122 (57%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G +K+ DFGL+ + + L++ G++Y+ APE++N + GP D+WS G + ++ Sbjct: 278 GDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVDVWSFGIVLYVLVCG 337 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVN 367 ++P+ D + +I KG PS +S + + +S+ + +P R + ++L+HP++ Sbjct: 338 KVPFDDQNMSALHAKIKKG-TVEYPSYLSSDCKGLLSRMLVTDPLKRATLEEVLNHPWMI 396 Query: 368 RS 373 R+ Sbjct: 397 RN 398
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 70.1 bits (170), Expect = 5e-12 Identities = 38/116 (32%), Positives = 62/116 (53%), Gaps = 1/116 (0%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +VK++DFG +K+ S + S GTV WMAPEV+ + DIWS G + E+LT + Sbjct: 292 AVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGE 350 Query: 191 LPYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 +PY D++ + ++ +G +PS + + Q + P +RPS + L H Sbjct: 351 IPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 406
>ATG1_BOTCI (Q6H9I1) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Botryotinia fuckeliana putative kinase exons 1-3) Length = 952 Score = 69.7 bits (169), Expect = 7e-12 Identities = 39/120 (32%), Positives = 67/120 (55%), Gaps = 3/120 (2%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 +KLADFG A+ ++ ++ G+ +MAPE++ +K Y AD+WS+G + EM+T + Sbjct: 211 LKLADFGFARSLPSTSLAETLCGSPLYMAPEILRYEK-YDARADLWSIGTVLYEMMTGRP 269 Query: 194 PYPDLEWTQALYRIGKGEPP-AIPS--AISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P+ + Q L +I K + PS S++ +D + + +K PEDR + + HP V Sbjct: 270 PFKAINHVQLLQKIEKNQDEIRFPSRGIYSRDLKDIVRRLLKKKPEDRITFPEYFAHPVV 329
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 69.3 bits (168), Expect = 9e-12 Identities = 36/118 (30%), Positives = 64/118 (54%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 AN ++K+ADFGL+ + ++L + G+ + APE+++ K GP D+WS G + ML Sbjct: 157 ANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAML 216 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 LP+ D +I G +P ++ K+A D IS ++ +P R ++++H Sbjct: 217 CGTLPFDDQNVPTLFAKIKSGR-YTVPYSMEKQAADLISTMLQVDPVKRADVKRIVNH 273
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 69.3 bits (168), Expect = 9e-12 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 4/121 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A G VKL D GL + +SK S GT Y+M+PE ++ + Y +DIWSLGC + EM Sbjct: 171 ATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEM 229 Query: 179 LTRQLPY--PDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRPSASKLL 349 Q P+ + +I + + P +PS S+E R ++ C+ P+PE RP + + Sbjct: 230 AALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVY 289 Query: 350 D 352 D Sbjct: 290 D 290
>MP2K5_HUMAN (Q13163) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 438 Score = 69.3 bits (168), Expect = 9e-12 Identities = 39/119 (32%), Positives = 68/119 (57%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G VKL DFG++ Q ++ K+ GT +MAPE ++ ++ YG +D+WSLG + +E+ Sbjct: 295 GQVKLCDFGVSTQLVN-SIAKTYVGTNAYMAPERISGEQ-YGIHSDVWSLGISFMEIQKN 352 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 Q L+ Q + + + P S+ FI+QC++ P++RP+ +L+ HPF+ Sbjct: 353 QGSLMPLQLLQCI--VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 409
>PLK3_MOUSE (Q60806) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) Length = 631 Score = 68.9 bits (167), Expect = 1e-11 Identities = 40/123 (32%), Positives = 68/123 (55%), Gaps = 1/123 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N +K+ DFGLA + K + GT ++APEV+ ++ +GP AD+WSLGC + +L Sbjct: 197 NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLL 255 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + + YR K +P+++S AR ++ ++ +P DRPS ++L H F Sbjct: 256 CGSPPFETADLKET-YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDF 314 Query: 362 VNR 370 + Sbjct: 315 FTK 317
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 68.9 bits (167), Expect = 1e-11 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 1/116 (0%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +VK++DFG +K+ S + S GTV W+APEV+ + DIWS G + E+LT + Sbjct: 292 AVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIR-NEPVSEKVDIWSFGVVLWELLTGE 350 Query: 191 LPYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 +PY D++ + ++ +G +PS + + Q + P +RPS + L H Sbjct: 351 IPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 406
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 68.9 bits (167), Expect = 1e-11 Identities = 40/123 (32%), Positives = 68/123 (55%), Gaps = 1/123 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N +K+ DFGLA + K + GT ++APEV+ ++ +GP AD+WSLGC + +L Sbjct: 196 NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLL 254 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + + YR K +P+++S AR ++ ++ +P DRPS ++L H F Sbjct: 255 CGSPPFETADLKET-YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDF 313 Query: 362 VNR 370 + Sbjct: 314 FTK 316
>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) Length = 984 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/145 (31%), Positives = 72/145 (49%), Gaps = 8/145 (5%) Frame = +2 Query: 14 VKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +KL D+GLAK+ S+ ++ ++ GT Y+M+PE+ K Y +DIW++GC + E+LT + Sbjct: 190 IKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVK-YNFKSDIWAVGCVIFELLTLK 248 Query: 191 LPYPDLEWTQALYRIGKG--EPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + +I +G S S E + C+ +PE RP+A LLD P + Sbjct: 249 RTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAADALLDLPLL 308 Query: 365 NRSMRSIRSMRTY-----TRPNSST 424 R + T RP SST Sbjct: 309 RTRRREMEEKVTLLNAPTKRPRSST 333
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 68.9 bits (167), Expect = 1e-11 Identities = 40/123 (32%), Positives = 68/123 (55%), Gaps = 1/123 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N +K+ DFGLA + K + GT ++APEV+ ++ +GP AD+WSLGC + +L Sbjct: 165 NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLL 223 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + + YR K +P+++S AR ++ ++ +P DRPS ++L H F Sbjct: 224 CGSPPFETADLKET-YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDF 282 Query: 362 VNR 370 + Sbjct: 283 FTK 285
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 68.9 bits (167), Expect = 1e-11 Identities = 38/129 (29%), Positives = 67/129 (51%), Gaps = 3/129 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ---TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVL 172 + G VKL DFG + Q T V + GT Y++APE+ N K+ Y AD+WSLG + Sbjct: 157 STGLVKLGDFGFSHQYEDTVSGVVASTFCGTPYYLAPELWNNKR-YNKKADVWSLGVLLY 215 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 E++ + P+ + ++ G +P + S E + + + +P DRPS ++ Sbjct: 216 EIMGMKKPFSASNLKGLMSKVLAGTYAPLPDSFSSEFKRVVDGILVADPNDRPSVREIFQ 275 Query: 353 HPFVNRSMR 379 P++N+ ++ Sbjct: 276 IPYINKGLK 284
>WIN1_SCHPO (O74304) MAP kinase kinase kinase win1 (EC 2.7.11.25)| Length = 1436 Score = 68.6 bits (166), Expect = 2e-11 Identities = 40/103 (38%), Positives = 60/103 (58%), Gaps = 5/103 (4%) Frame = +2 Query: 71 SCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEMLTRQLPYPDLE-WTQALYRIGK 241 S GT +MAPE++ NP + G A DIWSLGC ++EM T P+P L+ +Y I Sbjct: 1305 SLTGTPTYMAPELILGNPSERVG-AMDIWSLGCVIVEMATGSPPWPRLDNHFSLMYHIAA 1363 Query: 242 GEPPAIPS--AISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 PP IP+ +S ++F+ +C +P R +A++LL P+V Sbjct: 1364 HNPPIIPADDQLSPLGQNFLKRCFVSDPNQRATAAELLMDPWV 1406
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 68.6 bits (166), Expect = 2e-11 Identities = 44/120 (36%), Positives = 64/120 (53%), Gaps = 1/120 (0%) Frame = +2 Query: 8 GSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G +KL DFG A+ S VL S KGT +M+PE+V ++ Y AD+WS+GC + E+ Sbjct: 137 GGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVE-ERPYDHTADLWSVGCILYELAV 195 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P+ Q + I K +P PS IS ++F+ + +P R S LL HPF+ Sbjct: 196 GTPPFYATSIFQLVSLILK-DPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 68.6 bits (166), Expect = 2e-11 Identities = 44/120 (36%), Positives = 64/120 (53%), Gaps = 1/120 (0%) Frame = +2 Query: 8 GSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G +KL DFG A+ S VL S KGT +M+PE+V ++ Y AD+WS+GC + E+ Sbjct: 137 GGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVE-ERPYDHTADLWSVGCILYELAV 195 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P+ Q + I K +P PS IS ++F+ + +P R S LL HPF+ Sbjct: 196 GTPPFYATSIFQLVSLILK-DPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/140 (30%), Positives = 72/140 (51%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 +G +KL+DFG + C GT+ ++ PE+V K+ + D+WSLG E L Sbjct: 223 DGEIKLSDFGWSVHAPSNRRTTLC-GTLDYLPPEMVEGKE-HTEKVDLWSLGVLTYEFLV 280 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P+ D+ A Y+ IPS + +ARD IS+ ++ NPE R S +++ HP++ Sbjct: 281 GAPPFEDMSGHSATYKRIAKVDLKIPSFVPPDARDLISRLLQHNPEKRMSLEQVMRHPWI 340 Query: 365 NRSMRSIRSMRTYTRPNSST 424 ++ ++TR +S + Sbjct: 341 ------VKYKDSWTRKSSES 354
>BYR1_SCHPO (P10506) Protein kinase byr1 (EC 2.7.12.2) (MAPK kinase) (MAPKK)| Length = 340 Score = 68.2 bits (165), Expect = 2e-11 Identities = 39/131 (29%), Positives = 73/131 (55%), Gaps = 6/131 (4%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 + G +KL DFG++ + +V ++ GT +M+PE + K Y +DIWSLG +++E+ Sbjct: 196 SRGEIKLCDFGVSGELVN-SVAQTFVGTSTYMSPERIRGGK-YTVKSDIWSLGISIIELA 253 Query: 182 TRQLPYP------DLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASK 343 T++LP+ + L+ I + EPP +PS+ ++ R F+ C+ +P R S + Sbjct: 254 TQELPWSFSNIDDSIGILDLLHCIVQEEPPRLPSSFPEDLRLFVDACLHKDPTLRASPQQ 313 Query: 344 LLDHPFVNRSM 376 L P+ +++ Sbjct: 314 LCAMPYFQQAL 324
>JIL1_DROME (Q9V3I5) Chromosomal serine/threonine-protein kinase JIL-1 (EC| 2.7.11.1) Length = 1207 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/132 (34%), Positives = 72/132 (54%), Gaps = 12/132 (9%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLK--SCKGTVYWMAPEVVNPKKT-YGPAADIWSLGCTVLEM 178 G + L+DFGL+K + N + S GT+ +MAPE++ + A D WS+G E+ Sbjct: 401 GHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFEL 460 Query: 179 LTRQLPYP----DLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDR-----P 331 LT P+ ++ ++ RI K E P IPS+ S ARDF+ + ++ NP+ R Sbjct: 461 LTGASPFATSDGQVQQSEISRRIQK-EQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHR 519 Query: 332 SASKLLDHPFVN 367 AS++ +HPF N Sbjct: 520 DASEIKEHPFFN 531 Score = 47.8 bits (112), Expect = 3e-05 Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 15/129 (11%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSC-KGTVYWMAPEVVNPKK--TYGPAADIWSLGCTVLEML 181 +VKL DFG A ++ K + T+ + PE++ TY PA DI+ LG T+ ML Sbjct: 754 TVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTML 813 Query: 182 TRQLPY----PDLEWTQALY-----RIGKG---EPPAIPSAISKEARDFISQCVKPNPED 325 PY D++ + A + R+ +G + + S R +S C++ +P D Sbjct: 814 VGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPAD 873 Query: 326 RPSASKLLD 352 RP+ S +LD Sbjct: 874 RPTLSDILD 882
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 67.8 bits (164), Expect = 3e-11 Identities = 36/118 (30%), Positives = 61/118 (51%), Gaps = 1/118 (0%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +N +K+ DFGLA++ + + S GT WMAPEV+ + +D+WS G + E+L Sbjct: 286 SNKILKITDFGLAREWHRTTKM-SAAGTYAWMAPEVIRASM-FSKGSDVWSYGVLLWELL 343 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPA-IPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 T ++P+ ++ Y + + IPS + + C P+P RPS + +LD Sbjct: 344 TGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILD 401
>NEK2_HUMAN (P51955) Serine/threonine-protein kinase Nek2 (EC 2.7.11.1)| (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) Length = 445 Score = 67.8 bits (164), Expect = 3e-11 Identities = 38/119 (31%), Positives = 65/119 (54%), Gaps = 1/119 (0%) Frame = +2 Query: 11 SVKLADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 +VKL DFGLA+ + + K+ GT Y+M+PE +N + +Y +DIWSLGC + E+ Sbjct: 154 NVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN-RMSYNEKSDIWSLGCLLYELCAL 212 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P+ + +I +G+ IP S E + I++ + RPS ++L++P + Sbjct: 213 MPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 67.8 bits (164), Expect = 3e-11 Identities = 42/129 (32%), Positives = 72/129 (55%), Gaps = 3/129 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLN---VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVL 172 A+G++K++DFGL+ T ++ +L + GT ++APEV+ + G AADIWS G + Sbjct: 153 ASGNLKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDRGYDGAAADIWSCGVILY 212 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 +L LP+ D + ALY+ PS S A+ I++ + PNP R + S++L+ Sbjct: 213 VLLAGFLPFED-DNIIALYKKISEAQFTCPSWFSTGAKKLITRILDPNPTTRITISQILE 271 Query: 353 HPFVNRSMR 379 P+ + + Sbjct: 272 DPWFKKGYK 280
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 67.8 bits (164), Expect = 3e-11 Identities = 43/143 (30%), Positives = 72/143 (50%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N +VK+ADFGL+ + N LK+ G+ + APEV+N K GP D+WS G + ML Sbjct: 167 NLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLV 226 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 +LP+ D E+ L++ +P +S A+ I + + +P R + ++ P+ Sbjct: 227 GRLPFDD-EFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 285 Query: 365 NRSMRSIRSMRTYTRPNSSTRGT 433 N ++ Y RP +G+ Sbjct: 286 NVNLPD------YLRPMEEVQGS 302
>POLO_DROME (P52304) Serine/threonine-protein kinase polo (EC 2.7.11.21)| Length = 576 Score = 67.4 bits (163), Expect = 4e-11 Identities = 42/121 (34%), Positives = 65/121 (53%), Gaps = 1/121 (0%) Frame = +2 Query: 14 VKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 VK+ DFGLA + + K+ GT ++APE++ KK + DIWS+GC + +L Q Sbjct: 162 VKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILT-KKGHSFEVDIWSIGCVMYTLLVGQ 220 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVNR 370 P+ +I K E +PS + K A D + ++PNPE RP+ +LL+ F+ Sbjct: 221 PPFETKTLKDTYSKIKKCEY-RVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKG 279 Query: 371 S 373 S Sbjct: 280 S 280
>WNK1_RAT (Q9JIH7) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2126 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/120 (34%), Positives = 65/120 (54%), Gaps = 2/120 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 GSVK+ D GLA + + KS GT +MAPE+ K Y + D+++ G +LEM T Sbjct: 362 GSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYEEK--YDESVDVYAFGMCMLEMATS 418 Query: 188 QLPYPDLEWTQALY-RIGKGEPPAIPSAIS-KEARDFISQCVKPNPEDRPSASKLLDHPF 361 + PY + + +Y R+ G PA ++ E ++ I C++ N ++R S LL+H F Sbjct: 419 EYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAF 478
>MAPK3_BOVIN (Q3SYZ2) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 67.4 bits (163), Expect = 4e-11 Identities = 44/129 (34%), Positives = 77/129 (59%), Gaps = 8/129 (6%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 +KL DFG AK+T++ N L++ T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 185 LKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGFP 242 Query: 194 PYPDLEWTQAL-------YRIGK-GEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ QA+ R+G+ G P S +S++A+ I +K +P +R + ++ + Sbjct: 243 PFYS-NTGQAISPGMKRRIRLGQYGFPSPEWSEVSEDAKQLIRLLLKTDPTERLTITQFM 301 Query: 350 DHPFVNRSM 376 +HP++N+SM Sbjct: 302 NHPWINQSM 310
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/114 (35%), Positives = 67/114 (58%), Gaps = 2/114 (1%) Frame = +2 Query: 2 ANGSVKLADFGLAKQT--SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLE 175 A+G +K+ DFGL+K+ S+ C GTV +MAPEV+N ++ + AAD WSLG + E Sbjct: 239 ADGHIKVTDFGLSKEAIDSEKKTYSFC-GTVEYMAPEVIN-RRGHSMAADFWSLGVLMFE 296 Query: 176 MLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSA 337 MLT LP+ + + +I K + ++P +++EA+ + K N ++R A Sbjct: 297 MLTGHLPFQGRDRNDTMTQILKAK-LSMPHFLTQEAQSLLRALFKRNSQNRLGA 349 Score = 60.1 bits (144), Expect = 6e-09 Identities = 41/127 (32%), Positives = 69/127 (54%), Gaps = 7/127 (5%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 S+++ DFG AKQ+ N +L + T ++APEV+ K+ Y + D+WSLG + MLT Sbjct: 589 SLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLR-KQGYDRSCDVWSLGVLLHTMLTG 647 Query: 188 QLPY---PDLEWTQALYRIGKGE---PPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ P+ Q L R+G G+ + IS EA+D + + + +P R +A + L Sbjct: 648 CTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQAL 707 Query: 350 DHPFVNR 370 H ++ + Sbjct: 708 QHKWIGQ 714
>WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/120 (34%), Positives = 65/120 (54%), Gaps = 2/120 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 GSVK+ D GLA + + KS GT +MAPE+ K Y + D+++ G +LEM T Sbjct: 362 GSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYEEK--YDESVDVYAFGMCMLEMATS 418 Query: 188 QLPYPDLEWTQALY-RIGKGEPPAIPSAIS-KEARDFISQCVKPNPEDRPSASKLLDHPF 361 + PY + + +Y R+ G PA ++ E ++ I C++ N ++R S LL+H F Sbjct: 419 EYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAF 478
>WNK1_MOUSE (P83741) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2377 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/120 (34%), Positives = 65/120 (54%), Gaps = 2/120 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 GSVK+ D GLA + + KS GT +MAPE+ K Y + D+++ G +LEM T Sbjct: 362 GSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYEEK--YDESVDVYAFGMCMLEMATS 418 Query: 188 QLPYPDLEWTQALY-RIGKGEPPAIPSAIS-KEARDFISQCVKPNPEDRPSASKLLDHPF 361 + PY + + +Y R+ G PA ++ E ++ I C++ N ++R S LL+H F Sbjct: 419 EYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAF 478
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 67.0 bits (162), Expect = 5e-11 Identities = 39/117 (33%), Positives = 66/117 (56%), Gaps = 1/117 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKL-NVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +K+ DFGLA + L + ++ GT +++PEV+N K+ +G +DIW+LGC + ML + Sbjct: 216 LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLLGR 274 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + YR + +PS++ A+ I+ + NPEDRPS ++ H F Sbjct: 275 PPFETTNLKET-YRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDF 330
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 67.0 bits (162), Expect = 5e-11 Identities = 39/117 (33%), Positives = 66/117 (56%), Gaps = 1/117 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKL-NVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +K+ DFGLA + L + ++ GT +++PEV+N K+ +G +DIW+LGC + ML + Sbjct: 216 LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLLGR 274 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + YR + +PS++ A+ I+ + NPEDRPS ++ H F Sbjct: 275 PPFETTNLKET-YRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDF 330
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 67.0 bits (162), Expect = 5e-11 Identities = 39/117 (33%), Positives = 66/117 (56%), Gaps = 1/117 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKL-NVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +K+ DFGLA + L + ++ GT +++PEV+N K+ +G +DIW+LGC + ML + Sbjct: 219 LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLLGR 277 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + YR + +PS++ A+ I+ + NPEDRPS ++ H F Sbjct: 278 PPFETTNLKET-YRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDF 333
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 67.0 bits (162), Expect = 5e-11 Identities = 41/145 (28%), Positives = 73/145 (50%), Gaps = 11/145 (7%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G +KL DFG++ + ++ + GT ++MAPE + + Y D+WSLG T+LE+ Sbjct: 354 GEIKLCDFGVSGEAVN-SLAMTFTGTSFYMAPERIQGQP-YSVTCDVWSLGLTLLEVAGG 411 Query: 188 QLPYPDLEWTQALYRIGK-----------GEPPAIPSAISKEARDFISQCVKPNPEDRPS 334 + P+ + TQ + I + P + + SK R FI C+K + +RPS Sbjct: 412 RFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPS 471 Query: 335 ASKLLDHPFVNRSMRSIRSMRTYTR 409 ++L HP++ M+ +M + + Sbjct: 472 PRQMLKHPWIVGQMKKKVNMERFVK 496
>MAPK3_HUMAN (Q16644) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK) Length = 382 Score = 67.0 bits (162), Expect = 5e-11 Identities = 44/129 (34%), Positives = 77/129 (59%), Gaps = 8/129 (6%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 +KL DFG AK+T++ N L++ T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 183 LKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGFP 240 Query: 194 PYPDLEWTQAL-------YRIGK-GEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ QA+ R+G+ G P S +S++A+ I +K +P +R + ++ + Sbjct: 241 PFYS-NTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFM 299 Query: 350 DHPFVNRSM 376 +HP++N+SM Sbjct: 300 NHPWINQSM 308
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 67.0 bits (162), Expect = 5e-11 Identities = 40/117 (34%), Positives = 64/117 (54%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +VK+ADFGL+ + LK+ G+ + APEV++ K GP D+WS G + +L Sbjct: 178 NVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGT 237 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 LP+ D E L++ KG +PS +S ARD I + + +P R + ++ HP+ Sbjct: 238 LPFDD-ENIPNLFKKIKGGIYTLPSHLSPGARDLIPRMLVVDPMKRVTIPEIRQHPW 293
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 67.0 bits (162), Expect = 5e-11 Identities = 43/147 (29%), Positives = 71/147 (48%), Gaps = 12/147 (8%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLE--- 175 NG VKL DFG++ + ++ + GT ++MAPE + + Y +D+WSLG T+LE Sbjct: 360 NGQVKLCDFGVSGEAVN-SLATTFTGTSFYMAPERIQGQP-YSVTSDVWSLGLTILEVAN 417 Query: 176 ---------MLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDR 328 M P+ L W K EP + S + FI C+K + +R Sbjct: 418 GKFPCSSEKMAANIAPFELLMWILTFTPELKDEPES-NIIWSPSFKSFIDYCLKKDSRER 476 Query: 329 PSASKLLDHPFVNRSMRSIRSMRTYTR 409 PS ++++HP++ M+ +M + R Sbjct: 477 PSPRQMINHPWIKGQMKKNVNMEKFVR 503
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 67.0 bits (162), Expect = 5e-11 Identities = 49/161 (30%), Positives = 73/161 (45%), Gaps = 29/161 (18%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A+GS+KLADFGLA+ + T+++ APE++ K Y A DIWSLGC EM Sbjct: 137 ADGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM 196 Query: 179 LTRQLPYPDLEWTQALYRIGK--GEP---------------PAIPS-----------AIS 274 +TR+ +P L+RI + G P P+ P + Sbjct: 197 VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD 256 Query: 275 KEARDFISQCVKPNPEDRPSASKLLDHPFVNRSMRSIRSMR 397 ++ R +SQ + +P R SA L HPF + + +R Sbjct: 257 EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297
>SRK1_SCHPO (O94547) Serine/threonine-protein kinase srk1 (EC 2.7.11.1)| (Sty1-regulated kinase 1) Length = 580 Score = 66.6 bits (161), Expect = 6e-11 Identities = 40/125 (32%), Positives = 66/125 (52%), Gaps = 3/125 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G ++LADFGL+K + C GT+ + APE+V ++ Y D+W+LGC + +L Sbjct: 302 GRIRLADFGLSKVVWDSHTQTPC-GTMGYTAPEIVRDER-YSKGVDMWALGCVLYTILCG 359 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIP---SAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 P+ D + ++ +GE + ISK A+D IS + +PE R + L HP Sbjct: 360 FPPFYDESISLLTKKVSRGEYSFLSPWWDDISKSAKDLISHLLTVDPESRYDIHQFLAHP 419 Query: 359 FVNRS 373 +++ S Sbjct: 420 WISGS 424
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 66.6 bits (161), Expect = 6e-11 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 29/161 (18%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A GS+KLADFGLA+ + T+++ APE++ K Y A DIWSLGC EM Sbjct: 137 AEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM 196 Query: 179 LTRQLPYPDLEWTQALYRIGK--GEP---------------PAIPS-----------AIS 274 +TR+ +P L+RI + G P P+ P + Sbjct: 197 VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD 256 Query: 275 KEARDFISQCVKPNPEDRPSASKLLDHPFVNRSMRSIRSMR 397 ++ R +SQ + +P R SA L HPF + + +R Sbjct: 257 EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 66.6 bits (161), Expect = 6e-11 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 29/161 (18%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A GS+KLADFGLA+ + T+++ APE++ K Y A DIWSLGC EM Sbjct: 137 AEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM 196 Query: 179 LTRQLPYPDLEWTQALYRIGK--GEP---------------PAIPS-----------AIS 274 +TR+ +P L+RI + G P P+ P + Sbjct: 197 VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD 256 Query: 275 KEARDFISQCVKPNPEDRPSASKLLDHPFVNRSMRSIRSMR 397 ++ R +SQ + +P R SA L HPF + + +R Sbjct: 257 EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 66.6 bits (161), Expect = 6e-11 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 29/161 (18%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A GS+KLADFGLA+ + T+++ APE++ K Y A DIWSLGC EM Sbjct: 137 AEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM 196 Query: 179 LTRQLPYPDLEWTQALYRIGK--GEP---------------PAIPS-----------AIS 274 +TR+ +P L+RI + G P P+ P + Sbjct: 197 VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD 256 Query: 275 KEARDFISQCVKPNPEDRPSASKLLDHPFVNRSMRSIRSMR 397 ++ R +SQ + +P R SA L HPF + + +R Sbjct: 257 EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 66.6 bits (161), Expect = 6e-11 Identities = 38/141 (26%), Positives = 79/141 (56%), Gaps = 5/141 (3%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 ++K+ADFG+A + ++L++ G+ ++ APE+V+ G A+D+WS G + +LT + Sbjct: 165 NIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGR 224 Query: 191 LPYPDLEWT--QALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 LP+ + L ++ KG+ + IS++A+D I + + +P R +L HP Sbjct: 225 LPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPL 284 Query: 362 VNR--SMRSIRSMRTYTRPNS 418 + + +++ +S++ R N+ Sbjct: 285 LKKYQTIKDSKSIKDLPRENT 305
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 66.6 bits (161), Expect = 6e-11 Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 1/117 (0%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 A+ +K+ DFGLA++ K + S GT WMAPEV+ + ++D+WS G + E+L Sbjct: 240 ADTVLKITDFGLAREWHKTTKM-SAAGTYAWMAPEVIR-LSLFSKSSDVWSFGVLLWELL 297 Query: 182 TRQLPYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 T ++PY +++ Y + + IPS + + +C P+P RP +L Sbjct: 298 TGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSIL 354
>M4K3_MOUSE (Q99JP0) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragments) Length = 681 Score = 66.6 bits (161), Expect = 6e-11 Identities = 43/116 (37%), Positives = 60/116 (51%), Gaps = 7/116 (6%) Frame = +2 Query: 5 NGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEV--VNPKKTYGPAADIWSLGCTVLE 175 NG VKLADFG++ Q T+ + KS GT YWMAPEV V K Y D+W++G T +E Sbjct: 147 NGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIE 206 Query: 176 MLTRQLPYPDLEWTQALYRIGKG--EPPAIPSAI--SKEARDFISQCVKPNPEDRP 331 + Q P DL +AL+ + K +PP + + S F+ + P P Sbjct: 207 LAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTAKPSHVP 262
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 66.2 bits (160), Expect = 8e-11 Identities = 38/127 (29%), Positives = 69/127 (54%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 NG VK++DFG + T L C GT+ ++ PE++ +K Y D+W +G E+L Sbjct: 150 NGEVKISDFGWSVHTPSLRRKTMC-GTLDYLPPEMI-AQKPYNEMVDLWCIGVLCYELLV 207 Query: 185 RQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + P+ ++ RI + + PS++ A+D IS+ ++ +P +R S +++L HP+V Sbjct: 208 GKPPFESSTSSETYRRIRQVDFK-FPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWV 266 Query: 365 NRSMRSI 385 R + Sbjct: 267 REHSRRV 273
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 66.2 bits (160), Expect = 8e-11 Identities = 39/115 (33%), Positives = 63/115 (54%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 ++K+ADFGL+ + LK+ G+ + APEV++ K GP D+WS G + +L Sbjct: 156 NIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGT 215 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 LP+ D E L++ KG +PS +S EARD I + + +P R + ++ H Sbjct: 216 LPFDD-ENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQH 269
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 65.9 bits (159), Expect = 1e-10 Identities = 40/132 (30%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLN---VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLE 175 NG++K++DFGL+ T ++ +L + GT ++APE+++ K G D+WS G + Sbjct: 156 NGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILSKKGYEGAKVDVWSCGIVLFV 215 Query: 176 MLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDH 355 ++ LP+ D +I KGE P +S + + F+S+ + NPE R + ++L Sbjct: 216 LVAGYLPFNDPNVMNMYKKIYKGE-YRFPRWMSPDLKRFVSRLLDINPETRITIDEILKD 274 Query: 356 P-FVNRSMRSIR 388 P FV + I+ Sbjct: 275 PWFVRGGFKQIK 286
>RCK2_YEAST (P38623) Serine/threonine-protein kinase RCK2 (EC 2.7.11.1) (CAM| kinase-like protein kinase CLK1) Length = 610 Score = 65.9 bits (159), Expect = 1e-10 Identities = 43/123 (34%), Positives = 63/123 (51%), Gaps = 3/123 (2%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G VKLADFGL+KQ N C GTV + APEVV + Y D+W +GC + ML Sbjct: 359 GIVKLADFGLSKQIFSKNTKTPC-GTVGYTAPEVVKDEH-YSMKVDMWGIGCVLYTMLCG 416 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIP---SAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 P+ D + +I +GE + IS A++ +S+ ++ P R + LD P Sbjct: 417 FPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVSKLLELEPSKRYDIDQFLDDP 476 Query: 359 FVN 367 ++N Sbjct: 477 WLN 479
>NEK11_MACFA (Q8WNU8) Serine/threonine-protein kinase Nek11 (EC 2.7.11.1)| (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11) Length = 637 Score = 65.9 bits (159), Expect = 1e-10 Identities = 33/128 (25%), Positives = 66/128 (51%), Gaps = 1/128 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQT-SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N +K+ DFG+++ ++ + GT ++M+PE + + Y +DIWSL C + EM Sbjct: 168 NNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK-HQGYDTKSDIWSLACILYEMC 226 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + + + +I +G+ P++P KE + + NP RPSA ++L P+ Sbjct: 227 CMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNTIMESMLNKNPSLRPSAIEILKIPY 286 Query: 362 VNRSMRSI 385 ++ ++ + Sbjct: 287 IDEQLQHL 294
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 65.9 bits (159), Expect = 1e-10 Identities = 46/136 (33%), Positives = 76/136 (55%), Gaps = 11/136 (8%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVV--NPKKTYGPAADIWSLGCTVLEMLTR 187 +K++DFGL+K K +V+++ GT ++APEV+ ++ Y DIWSLG + L+ Sbjct: 320 LKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSG 379 Query: 188 QLPYPDLEWTQALYRIGKGE-PPAIPS--AISKEARDFISQCVKPNPEDRPS------AS 340 LP+ D T A +I KG PS ++S+ A+ I+Q + +PE RPS +S Sbjct: 380 TLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSS 439 Query: 341 KLLDHPFVNRSMRSIR 388 L D P + ++ R ++ Sbjct: 440 WLRDAPMLQKAKRLMK 455
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 65.9 bits (159), Expect = 1e-10 Identities = 39/113 (34%), Positives = 62/113 (54%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +VK+ADFGL+ + N LK+ G+ + APEV++ K GP D+WS G + ML R+ Sbjct: 174 NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRR 233 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 LP+ D E L++ +P +S A D I + + NP +R S +++ Sbjct: 234 LPFDD-ESIPVLFKNISNGVYTLPKFLSPGASDLIKRMLIVNPLNRISIHEIM 285
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 65.9 bits (159), Expect = 1e-10 Identities = 37/122 (30%), Positives = 69/122 (56%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +VK+ADFGL+ + N LK+ G+ + APEV++ K GP D+WS G + ML + Sbjct: 187 NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSSGVILYVMLCGR 246 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVNR 370 LP+ D E+ AL++ +P+ +S A+ +++ + NP +R + ++++ + + Sbjct: 247 LPFDD-EFIPALFKKISNGVYTLPNYLSPGAKHLLTRMLVVNPLNRITIHEIMEDEWFKQ 305 Query: 371 SM 376 M Sbjct: 306 DM 307
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 65.9 bits (159), Expect = 1e-10 Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 1/113 (0%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 VK+ADFG + ++ K GT WMAPE++ +K Y D++S G + E+ T L Sbjct: 226 VKVADFGTSCLETQCREAKGNMGTYRWMAPEMIK-EKPYTRKVDVYSFGIVLWELTTALL 284 Query: 194 PYPDLEWTQALYRIG-KGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ + QA + + K E P +P++ I +C NP RP S ++ Sbjct: 285 PFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSNIV 337
>CDR2_SCHPO (P87050) Mitosis inducer protein kinase cdr2 (EC 2.7.11.1)| Length = 775 Score = 65.5 bits (158), Expect = 1e-10 Identities = 34/122 (27%), Positives = 70/122 (57%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 A+GS+K+ +FG+A +L++ G+ ++ +PE++ + G A+DIWS G +L Sbjct: 143 AHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALL 202 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 T +LP+ D L ++ +G+ +PS IS +A+ + + + + R + ++ +HPF Sbjct: 203 TGKLPFDDDNIRSLLLKVCQGQ-FEMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPF 261 Query: 362 VN 367 ++ Sbjct: 262 LS 263
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 65.5 bits (158), Expect = 1e-10 Identities = 39/123 (31%), Positives = 68/123 (55%), Gaps = 1/123 (0%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLK-SCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 +VK+ADFGL+ + N LK SC Y APEV++ K GP D+WS G + ML Sbjct: 188 NVKIADFGLSNIMTDGNFLKTSCGSPNYMPAPEVISGKLYAGPEVDVWSAGVILYVMLCG 247 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVN 367 +LP+ D E+ AL++ +P+ +S A+ +++ + NP +R + ++++ + Sbjct: 248 RLPFDD-EFIPALFKKISNGVYTLPNYLSAGAKHLLTRMLVVNPLNRITIHEIMEDDWFK 306 Query: 368 RSM 376 + M Sbjct: 307 QDM 309
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 65.5 bits (158), Expect = 1e-10 Identities = 43/148 (29%), Positives = 74/148 (50%), Gaps = 5/148 (3%) Frame = +2 Query: 5 NGSVKLADFGLAK--QTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 N + +ADFGL+ + S+ +L + GT +MAPEV + YG D+W++G + Sbjct: 168 NSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFR-RTGYGKPVDMWAIGVITYFL 226 Query: 179 LTRQLPYPDLEWTQALYRIGKGE---PPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 L+ P+ + + I E S IS+ A+DFI +C++ +P R +A+ L Sbjct: 227 LSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSKRLTAADAL 286 Query: 350 DHPFVNRSMRSIRSMRTYTRPNSSTRGT 433 HPF++ + ++ R N + R T Sbjct: 287 KHPFLSEKRPATSNLLPNVRENFNARKT 314
>NEK11_HUMAN (Q8NG66) Serine/threonine-protein kinase Nek11 (EC 2.7.11.1)| (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11) Length = 645 Score = 65.5 bits (158), Expect = 1e-10 Identities = 33/128 (25%), Positives = 67/128 (52%), Gaps = 1/128 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQT-SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N +K+ DFG+++ ++ + GT ++M+PE + + Y +DIWSL C + EM Sbjct: 168 NNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK-HQGYDTKSDIWSLACILYEMC 226 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + + + +I +G+ P++P KE + + NP RPSA ++L P+ Sbjct: 227 CMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPY 286 Query: 362 VNRSMRSI 385 ++ ++++ Sbjct: 287 LDEQLQNL 294
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 65.5 bits (158), Expect = 1e-10 Identities = 39/132 (29%), Positives = 63/132 (47%), Gaps = 1/132 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVL-KSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 N SVKL DFGL+K V +S GT Y+M+PE++ Y +D+W+LGC + E+ Sbjct: 162 NNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSPEIIR-SSPYSAKSDVWALGCVIFEIC 220 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 P+ + + I +G S + I C++ N + RP+ +LL P Sbjct: 221 MLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPI 280 Query: 362 VNRSMRSIRSMR 397 ++ + S R Sbjct: 281 LSDIRSKLESER 292
>MAPK3_RAT (Q66H84) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 65.1 bits (157), Expect = 2e-10 Identities = 43/129 (33%), Positives = 76/129 (58%), Gaps = 8/129 (6%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 +KL DFG AK+T++ N L++ T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 185 LKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGFP 242 Query: 194 PYPDLEWTQAL-------YRIGK-GEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ QA+ R+G+ G P + +S++A+ I +K +P +R + + + Sbjct: 243 PFYS-NTGQAISPGMKRRIRLGQYGFPKPEWADVSEDAKQLIRLLLKTDPTERLTIMQFM 301 Query: 350 DHPFVNRSM 376 +HP++N+SM Sbjct: 302 NHPWINQSM 310
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 65.1 bits (157), Expect = 2e-10 Identities = 45/146 (30%), Positives = 71/146 (48%), Gaps = 26/146 (17%) Frame = +2 Query: 5 NGSVKLADFGLAK--------------------QTSKLNVLKSCKGTVYWMAPEVVNPKK 124 NG +K DFG A+ +T LN + GT +MAPE ++ Sbjct: 1169 NGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMM---GTPMYMAPETISGSA 1225 Query: 125 TYGP--AADIWSLGCTVLEMLTRQLPYPDL--EWTQALYRIGKGEPPAIPS--AISKEAR 286 G A D+W+LGC VLEM T + P+ +L EW +Y + G P +P+ ++ R Sbjct: 1226 VKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWA-IMYHVAAGRIPQLPNRDEMTAAGR 1284 Query: 287 DFISQCVKPNPEDRPSASKLLDHPFV 364 F+ +C+ +P R +A +LL P++ Sbjct: 1285 AFLERCLVQDPTMRATAVELLIDPWM 1310
>NEK6_MOUSE (Q9ES70) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 65.1 bits (157), Expect = 2e-10 Identities = 39/114 (34%), Positives = 62/114 (54%), Gaps = 4/114 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A G VKL D GL + +S+ S GT Y+M+PE ++ + Y +DIWSLGC + EM Sbjct: 182 ATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEM 240 Query: 179 LTRQLPY--PDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRP 331 Q P+ + +I + + P +P S++ R+ +S C+ P+P+ RP Sbjct: 241 AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYPDPDHRP 294
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 65.1 bits (157), Expect = 2e-10 Identities = 36/119 (30%), Positives = 67/119 (56%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G VKL DFG + + L + G++ + APE++ + PA DIWSLG + ++ Sbjct: 152 GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCG 211 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 Q P+ + ++ L I + +PS +SKE +D I++ ++ +P+ R S ++ +HP++ Sbjct: 212 QPPFQEANDSETLTMIMDCK-YTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269
>SCK1_SCHPO (P50530) Serine/threonine-protein kinase sck1 (EC 2.7.11.1)| Length = 696 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/149 (32%), Positives = 72/149 (48%), Gaps = 11/149 (7%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCK-GTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A+G + L DFGL+K N + GT ++APEV+ K Y D WSLG V EM Sbjct: 438 ADGHIALCDFGLSKANLSANATTNTFCGTTEYLAPEVLLEDKGYTKQVDFWSLGVLVFEM 497 Query: 179 LTRQLPY--PDLEWTQALYR-IGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSA---- 337 P+ PD+ Q +YR I G+ +S E R F+ + NP R A Sbjct: 498 CCGWSPFYAPDV---QQMYRNIAFGKVRFPKGVLSSEGRSFVRGLLNRNPNHRLGAVADT 554 Query: 338 SKLLDHPF---VNRSMRSIRSMRTYTRPN 415 ++L +HPF +N + S + ++ +PN Sbjct: 555 TELKEHPFFADINWDLLSKKKVQPPFKPN 583
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 64.7 bits (156), Expect = 2e-10 Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 1/114 (0%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 ++K+ DFGLA++ K + S GT WMAPEV+ T+ +D+WS G + E+LT + Sbjct: 262 TLKITDFGLAREWHKTTQM-SAAGTYAWMAPEVIKAS-TFSKGSDVWSFGVLLWELLTGE 319 Query: 191 LPYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 +PY ++ Y + + IPS + ++ C +P RP + +L Sbjct: 320 VPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASIL 373
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 64.7 bits (156), Expect = 2e-10 Identities = 36/117 (30%), Positives = 62/117 (52%), Gaps = 1/117 (0%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N ++K+ DFGLA++ + + S GT WMAPEV+ + +DIWS G + E+LT Sbjct: 282 NKTLKITDFGLAREWHRTTKM-STAGTYAWMAPEVIK-SSLFSKGSDIWSYGVLLWELLT 339 Query: 185 RQLPYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 ++PY ++ Y + + IPS + + +C + +P RPS + +L+ Sbjct: 340 GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILE 396
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 64.7 bits (156), Expect = 2e-10 Identities = 46/161 (28%), Positives = 74/161 (45%), Gaps = 18/161 (11%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 ++K+ DFG K ++ + +G+ WMAPEV K Y DI+S + E+L+R+ Sbjct: 154 NLKICDFGTV--ADKSTMMTNNRGSAAWMAPEVFEGSK-YTEKCDIFSWAIVLWEVLSRK 210 Query: 191 LPYPDLEWTQAL-YRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPS----------- 334 P+ ++ + ++I KGE P + + K D ++ C K PEDRPS Sbjct: 211 QPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEI 270 Query: 335 ------ASKLLDHPFVNRSMRSIRSMRTYTRPNSSTRGTSG 439 A K L++ FVN+ + + S T S G Sbjct: 271 VKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEG 311
>KKCC1_HUMAN (Q8N5S9) Calcium/calmodulin-dependent protein kinase kinase 1 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase) Length = 505 Score = 64.7 bits (156), Expect = 2e-10 Identities = 43/128 (33%), Positives = 69/128 (53%), Gaps = 5/128 (3%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNV-LKSCKGTVYWMAPEVVNP--KKTYGPAADIWSLGCTVLE 175 +G VK+ADFG++ Q + L S GT +MAPE ++ + G A D+W+ G T+ Sbjct: 286 DGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYC 345 Query: 176 MLTRQLPYPDLEWTQALYRIGKGEPPAIPSA--ISKEARDFISQCVKPNPEDRPSASKLL 349 + + P+ D ++ AL+R K EP P IS+E +D I + + NPE R + Sbjct: 346 FVYGKCPFID-DFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIK 404 Query: 350 DHPFVNRS 373 HP+V ++ Sbjct: 405 LHPWVTKN 412
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 64.3 bits (155), Expect = 3e-10 Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 7/125 (5%) Frame = +2 Query: 8 GSVKLADFGLAKQT--SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 G +KL DFGL+K+ + C GTV +MAPEVVN ++ + +AD WS G + EML Sbjct: 217 GHIKLTDFGLSKEAIDHEKKAYSFC-GTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEML 274 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDR-----PSASKL 346 T LP+ + + + I K + +P +S EA+ + K NP +R A ++ Sbjct: 275 TGSLPFQGKDRKETMTLILKAK-LGMPQFLSAEAQSLLRALFKRNPANRLGSGPDGAEEI 333 Query: 347 LDHPF 361 HPF Sbjct: 334 KRHPF 338 Score = 57.8 bits (138), Expect = 3e-08 Identities = 43/138 (31%), Positives = 69/138 (50%), Gaps = 7/138 (5%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 S+++ DFG AKQ N +L + T ++APEV+ ++ Y DIWSLG + ML Sbjct: 569 SIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWSLGVLLYTMLAG 627 Query: 188 QLPY---PDLEWTQALYRIGKGEPPAIPS---AISKEARDFISQCVKPNPEDRPSASKLL 349 P+ P + L RIG G+ IS A+D +S+ + +P R +A ++L Sbjct: 628 CTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQVL 687 Query: 350 DHPFVNRSMRSIRSMRTY 403 HP++ + +S Y Sbjct: 688 QHPWITQKDSLPQSQLNY 705
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 64.3 bits (155), Expect = 3e-10 Identities = 40/112 (35%), Positives = 59/112 (52%), Gaps = 3/112 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLN---VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVL 172 A G +K+ DFGL+ +L + G+ ++APEV+ + G A+DIWS G + Sbjct: 153 AKGHIKITDFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLANRGYDGAASDIWSCGVILY 212 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDR 328 +LT LP+ D +I KG+PP IP +S AR I + + PNP R Sbjct: 213 VILTGCLPFDDRNLAVLYQKICKGDPP-IPRWLSPGARTMIKRMLDPNPVTR 263
>PMYT1_DROME (Q9NI63) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) (dMyt1) Length = 533 Score = 64.3 bits (155), Expect = 3e-10 Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 1/138 (0%) Frame = +2 Query: 17 KLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT-RQL 193 KLADFGL + N + +G +MAPE++ + AADI+SLG +LE+ L Sbjct: 240 KLADFGLVIDVDRANSHHATEGDSRYMAPEILQGH--FSKAADIFSLGIAMLELACYMDL 297 Query: 194 PYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVNRS 373 P W + + I P + IS E + I +KP+P RP+A +LL HP + Sbjct: 298 PSNGPLWHELRHGI---LPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYL 354 Query: 374 MRSIRSMRTYTRPNSSTR 427 + +S+ ++ + S R Sbjct: 355 QKKRKSLMNFSMLSRSFR 372
>WNK3_HUMAN (Q9BYP7) Serine/threonine-protein kinase WNK3 (EC 2.7.11.1)| (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) Length = 1743 Score = 64.3 bits (155), Expect = 3e-10 Identities = 39/120 (32%), Positives = 64/120 (53%), Gaps = 2/120 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 GSVK+ D GLA + + KS GT +MAPE+ ++ Y + D+++ G +LEM T Sbjct: 288 GSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMY--EEHYDESVDVYAFGMCMLEMATS 344 Query: 188 QLPYPDLEWTQALYR-IGKG-EPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + PY + + +YR + G +P + E ++ I C++ N +R S LL+H F Sbjct: 345 EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 64.3 bits (155), Expect = 3e-10 Identities = 43/125 (34%), Positives = 70/125 (56%), Gaps = 7/125 (5%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 S+++ DFG AKQ N +L + T ++APEV+ ++ Y A DIWSLG + MLT Sbjct: 556 SIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDAACDIWSLGVLLYTMLTG 614 Query: 188 QLPY---PDLEWTQALYRIGKGE---PPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ PD + L RIG G+ +++S A+D +S+ + +P R +A+ +L Sbjct: 615 YTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVL 674 Query: 350 DHPFV 364 HP++ Sbjct: 675 RHPWI 679 Score = 63.2 bits (152), Expect = 7e-10 Identities = 41/112 (36%), Positives = 62/112 (55%), Gaps = 2/112 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQT--SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 G +KL DFGL+K++ + C GTV +MAPEVVN ++ + +AD WS G + EML Sbjct: 205 GHIKLTDFGLSKESIDHEKKAYSFC-GTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEML 262 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSA 337 T LP+ + + + I K + +P +S EA+ + K NP +R A Sbjct: 263 TGTLPFQGKDRKETMTMILKAK-LGMPQFLSPEAQSLLRMLFKRNPANRLGA 313
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 64.3 bits (155), Expect = 3e-10 Identities = 43/125 (34%), Positives = 70/125 (56%), Gaps = 7/125 (5%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLN-VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 S+++ DFG AKQ N +L + T ++APEV+ ++ Y A DIWSLG + MLT Sbjct: 556 SIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQGYDAACDIWSLGVLLYTMLTG 614 Query: 188 QLPY---PDLEWTQALYRIGKGE---PPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 P+ PD + L RIG G+ +++S A+D +S+ + +P R +A+ +L Sbjct: 615 YTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVL 674 Query: 350 DHPFV 364 HP++ Sbjct: 675 RHPWI 679 Score = 63.2 bits (152), Expect = 7e-10 Identities = 41/112 (36%), Positives = 62/112 (55%), Gaps = 2/112 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQT--SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 G +KL DFGL+K++ + C GTV +MAPEVVN ++ + +AD WS G + EML Sbjct: 205 GHIKLTDFGLSKESIDHEKKAYSFC-GTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEML 262 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSA 337 T LP+ + + + I K + +P +S EA+ + K NP +R A Sbjct: 263 TGTLPFQGKDRKETMTMILKAK-LGMPQFLSPEAQSLLRMLFKRNPANRLGA 313
>NEK6_RAT (P59895) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 64.3 bits (155), Expect = 3e-10 Identities = 39/114 (34%), Positives = 61/114 (53%), Gaps = 4/114 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A G VKL D GL + +S+ S GT Y+M+PE ++ + Y +DIWSLGC + EM Sbjct: 182 ATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEM 240 Query: 179 LTRQLPY--PDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRP 331 Q P+ + +I + + P +P S++ R+ +S C+ P+P RP Sbjct: 241 AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYPDPNHRP 294
>NEK6_HUMAN (Q9HC98) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) (Protein kinase SID6-1512) Length = 313 Score = 64.3 bits (155), Expect = 3e-10 Identities = 39/114 (34%), Positives = 61/114 (53%), Gaps = 4/114 (3%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEM 178 A G VKL D GL + +S+ S GT Y+M+PE ++ + Y +DIWSLGC + EM Sbjct: 182 ATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEM 240 Query: 179 LTRQLPY--PDLEWTQALYRIGKGEPPAIPSA-ISKEARDFISQCVKPNPEDRP 331 Q P+ + +I + + P +P S++ R+ +S C+ P+P RP Sbjct: 241 AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRP 294
>NRKB_TRYBB (Q03428) Putative serine/threonine-protein kinase B (EC 2.7.11.1)| Length = 431 Score = 64.3 bits (155), Expect = 3e-10 Identities = 37/129 (28%), Positives = 65/129 (50%), Gaps = 3/129 (2%) Frame = +2 Query: 2 ANGSVKLADFGLAKQ---TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVL 172 + G VKL DFG + Q T V + GT Y++APE+ N + Y AD+WSLG + Sbjct: 157 STGLVKLGDFGFSHQYEDTVSGVVASTFCGTPYYLAPELWNNLR-YNKKADVWSLGVLLY 215 Query: 173 EMLTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLD 352 E++ + P+ + ++ G +P + S E + + + +P DRPS + Sbjct: 216 EIMGMKKPFSASNLKGLMSKVLAGTYAPLPDSFSSEFKRVVDGILVADPNDRPSVRENFQ 275 Query: 353 HPFVNRSMR 379 P++N+ ++ Sbjct: 276 IPYINKGLK 284
>KKCC1_RAT (P97756) Calcium/calmodulin-dependent protein kinase kinase 1 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (alpha CaMKK) (CaMKK 1) (CaM-kinase IV kinase) Length = 505 Score = 64.3 bits (155), Expect = 3e-10 Identities = 43/127 (33%), Positives = 68/127 (53%), Gaps = 5/127 (3%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNV-LKSCKGTVYWMAPEVVNP--KKTYGPAADIWSLGCTVLE 175 +G VK+ADFG++ Q + L S GT +MAPE ++ + G A D+W+ G T+ Sbjct: 286 DGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDTGQSFSGKALDVWATGVTLYC 345 Query: 176 MLTRQLPYPDLEWTQALYRIGKGEPPAIPSA--ISKEARDFISQCVKPNPEDRPSASKLL 349 + + P+ D E+ AL+R K E P +S+E +D I + + NPE R S + Sbjct: 346 FVYGKCPFID-EYILALHRKIKNEAVVFPEEPEVSEELKDLILKMLDKNPETRIGVSDIK 404 Query: 350 DHPFVNR 370 HP+V + Sbjct: 405 LHPWVTK 411
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 63.9 bits (154), Expect = 4e-10 Identities = 47/159 (29%), Positives = 71/159 (44%), Gaps = 29/159 (18%) Frame = +2 Query: 8 GSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G++KLADFGLA+ + T+++ APE++ K Y A DIWSLGC EM+T Sbjct: 139 GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 Query: 185 RQLPYPDLEWTQALYRIGK--GEP---------------PAIPS-----------AISKE 280 R+ +P L+RI + G P P+ P + ++ Sbjct: 199 RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDED 258 Query: 281 ARDFISQCVKPNPEDRPSASKLLDHPFVNRSMRSIRSMR 397 R +SQ + +P R SA L HPF + + +R Sbjct: 259 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 63.9 bits (154), Expect = 4e-10 Identities = 34/123 (27%), Positives = 67/123 (54%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 ++G +K+ DFGL+ L + G++Y+ APE++ + GP DIWS G + ++ Sbjct: 258 SSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLV 317 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 ++P+ D + +I KG+ PS +S E +++ + +P R + +++HP+ Sbjct: 318 CGKVPFDDENSSILHEKIKKGKVD-YPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPW 376 Query: 362 VNR 370 +NR Sbjct: 377 MNR 379
>NEK1_CAEEL (P84199) Serine/threonine-protein kinase D1044.8 (EC 2.7.11.1)| Length = 959 Score = 63.9 bits (154), Expect = 4e-10 Identities = 38/111 (34%), Positives = 53/111 (47%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 V + DFGLAKQ LKS GT+ + PE+V YG ADIWS GC + EM Q Sbjct: 583 VVITDFGLAKQKGP-EYLKSAAGTIIYSCPEIVQ-NLPYGEKADIWSFGCCIYEMCQLQP 640 Query: 194 PYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 + +I + + + S + R I+ C+ P+P RP K+ Sbjct: 641 VFHSTNMLTLAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSARPDILKV 691
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 63.9 bits (154), Expect = 4e-10 Identities = 40/109 (36%), Positives = 61/109 (55%), Gaps = 2/109 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQT--SKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 G +KL DFGL+K++ + C GTV +MAPEVVN ++ + +AD WS G + EML Sbjct: 210 GHIKLTDFGLSKESVDQEKKAYSFC-GTVEYMAPEVVN-RRGHSQSADWWSYGVLMFEML 267 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDR 328 T LP+ + + + I K + +P +S EA+ + K NP +R Sbjct: 268 TGTLPFQGKDRNETMNMILKAK-LGMPQFLSAEAQSLLRMLFKRNPANR 315 Score = 54.3 bits (129), Expect = 3e-07 Identities = 42/126 (33%), Positives = 64/126 (50%), Gaps = 8/126 (6%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLN--VLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 S+++ DFG AKQ N +L C T ++APEV+ ++ Y A DIWSLG ML Sbjct: 560 SIRICDFGFAKQLRGENGLLLTPCY-TANFVAPEVLM-QQGYDAACDIWSLGVLFYTMLA 617 Query: 185 RQLPY---PDLEWTQALYRIGKGE---PPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 P+ P+ + L RIG G+ IS A+D +S + +P R +A ++ Sbjct: 618 GYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQI 677 Query: 347 LDHPFV 364 L H ++ Sbjct: 678 LKHSWI 683
>MAPK2_MOUSE (P49138) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 386 Score = 63.5 bits (153), Expect = 5e-10 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 7/132 (5%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N +KL DFG AK+T+ N L + T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 186 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLC 244 Query: 185 RQLPYPD------LEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASK 343 P+ + R+G+ E P S +S+E + I +K P R + ++ Sbjct: 245 GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 304 Query: 344 LLDHPFVNRSMR 379 ++HP++ +S + Sbjct: 305 FMNHPWIMQSTK 316
>KC61_SCHPO (Q9UU87) Probable serine/threonine-protein kinase C1919.01 (EC| 2.7.11.1) Length = 354 Score = 63.5 bits (153), Expect = 5e-10 Identities = 39/122 (31%), Positives = 64/122 (52%), Gaps = 2/122 (1%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNP--KKTYGPAADIWSLGCTVLEM 178 N ++ + DFGLA+ K +K GT +MAPE+ + KK G DIWS+G T+ + Sbjct: 211 NNNLCVIDFGLAEFLPKDGFVKPASGTPAFMAPELFDNELKKIKGKPLDIWSMGVTLYVI 270 Query: 179 LTRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 + P+ + I KG+ IP+ + + R + +C++ NPE R + +LL P Sbjct: 271 AFAEFPFNGSTILDMINVI-KGKSLMIPAYCNSDLRKLLERCLEKNPEKRITIEELLRDP 329 Query: 359 FV 364 F+ Sbjct: 330 FL 331
>ATG1_NEUCR (Q7RX99) Serine/threonine-protein kinase atg-1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 932 Score = 63.5 bits (153), Expect = 5e-10 Identities = 39/120 (32%), Positives = 64/120 (53%), Gaps = 3/120 (2%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQL 193 +KLADFG A+ ++ ++ G+ +MAPE++ +K Y AD+WS+G + EM+T + Sbjct: 211 LKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYEK-YDAKADLWSVGTVLYEMVTGRP 269 Query: 194 PYPDLEWTQALYRI---GKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 P+ + L +I G S +S+E + I +K NP +R S L +HP V Sbjct: 270 PFKASNHVELLRKIESSGDVIKFTRESVVSQEMKGLIRALLKKNPVERISFEDLFNHPVV 329
>MAPK2_CRILO (P49136) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (P45-54 HSP27 kinase) (Fragment) Length = 329 Score = 63.5 bits (153), Expect = 5e-10 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 7/132 (5%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N +KL DFG AK+T+ N L + T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 129 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLC 187 Query: 185 RQLPYPD------LEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASK 343 P+ + R+G+ E P S +S+E + I +K P R + ++ Sbjct: 188 GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 247 Query: 344 LLDHPFVNRSMR 379 ++HP++ +S + Sbjct: 248 FMNHPWIMQSTK 259
>M3K8_MOUSE (Q07174) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene) Length = 467 Score = 63.5 bits (153), Expect = 5e-10 Identities = 45/123 (36%), Positives = 63/123 (51%), Gaps = 7/123 (5%) Frame = +2 Query: 20 LADFGLA-KQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQLP 196 L DFGL+ K T + + K +GT +M+PEV+ + + ADI+SLG T++ M T P Sbjct: 268 LVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVILCRG-HSTKADIYSLGATLIHMQTGTPP 326 Query: 197 ----YPDLEWTQALYRIGKGEPPA--IPSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 YP + LY I K PP I S R+ I ++ NP RP A+ LL H Sbjct: 327 WVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHE 386 Query: 359 FVN 367 +N Sbjct: 387 ALN 389
>ST17B_MOUSE (Q8BG48) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 63.5 bits (153), Expect = 5e-10 Identities = 36/127 (28%), Positives = 66/127 (51%), Gaps = 6/127 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGP---AADIWSLGCTVLEM 178 G +K+ DFG++++ + L+ GT ++APE++N Y P A D+W++G + Sbjct: 173 GDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILN----YDPITTATDMWNIGIIAYML 228 Query: 179 LTRQLPY---PDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 LT P+ + E + ++ + S++S+ A DFI + NPE RP+A L Sbjct: 229 LTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCL 288 Query: 350 DHPFVNR 370 H ++ + Sbjct: 289 SHSWLQQ 295
>MAPK2_HUMAN (P49137) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 400 Score = 63.5 bits (153), Expect = 5e-10 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 7/132 (5%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N +KL DFG AK+T+ N L + T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 200 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLC 258 Query: 185 RQLPYPD------LEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASK 343 P+ + R+G+ E P S +S+E + I +K P R + ++ Sbjct: 259 GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 Query: 344 LLDHPFVNRSMR 379 ++HP++ +S + Sbjct: 319 FMNHPWIMQSTK 330
>ST17B_RAT (Q91XS8) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 371 Score = 63.5 bits (153), Expect = 5e-10 Identities = 36/127 (28%), Positives = 66/127 (51%), Gaps = 6/127 (4%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGP---AADIWSLGCTVLEM 178 G +K+ DFG++++ + L+ GT ++APE++N Y P A D+W++G + Sbjct: 173 GDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILN----YDPITTATDMWNIGIIAYML 228 Query: 179 LTRQLPY---PDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 LT P+ + E + ++ + S++S+ A DFI + NPE RP+A L Sbjct: 229 LTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCL 288 Query: 350 DHPFVNR 370 H ++ + Sbjct: 289 SHSWLQQ 295
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 63.2 bits (152), Expect = 7e-10 Identities = 38/121 (31%), Positives = 62/121 (51%) Frame = +2 Query: 2 ANGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML 181 +NG +K+ADFG + C GT+ ++ PE++ + + D+WSLG E L Sbjct: 273 SNGELKIADFGWSVHAPSSRRTTLC-GTLDYLPPEMIEGRM-HDETVDLWSLGVLCYEFL 330 Query: 182 TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 + P+ + RI K E P +S+EARD +S+ +K NP R +L+HP+ Sbjct: 331 VGKPPFETDTHQETYRRISKVEFQ-YPPYVSEEARDLVSKLLKHNPNHRLPLKGVLEHPW 389 Query: 362 V 364 + Sbjct: 390 I 390
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 63.2 bits (152), Expect = 7e-10 Identities = 46/145 (31%), Positives = 68/145 (46%), Gaps = 8/145 (5%) Frame = +2 Query: 20 LADFGLAKQTSK-LNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQLP 196 LADFG+AK VL S G+ + APEV+ K+ +G A DIWSLG +L P Sbjct: 161 LADFGIAKMLDNPAEVLTSMAGSFGYAAPEVML-KQGHGKAVDIWSLGVITYTLLCGYSP 219 Query: 197 YPDLEWTQALYRIGKGEP---PAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFVN 367 + T + G +SK+A+DFI ++ +P RP++ + L HP++ Sbjct: 220 FRSENLTDLIEECRSGRVVFHERYWKDVSKDAKDFILSLLQVDPAQRPTSEEALKHPWLK 279 Query: 368 RSMRSIRSM----RTYTRPNSSTRG 430 S R + R Y + RG Sbjct: 280 GESASDRDLLPEIRAYIARSRLKRG 304
>PMYT1_MOUSE (Q9ESG9) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 490 Score = 63.2 bits (152), Expect = 7e-10 Identities = 40/123 (32%), Positives = 68/123 (55%), Gaps = 2/123 (1%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G KL DFGL + ++ +G +MAPE++ + +YG AAD++SLG T+LE+ Sbjct: 236 GRCKLGDFGLLVELGSTGAGEAQEGDPRYMAPELL--QGSYGTAADVFSLGLTILEVACN 293 Query: 188 -QLPYPDLEWTQALYRIGKGE-PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPF 361 +LP+ W Q + +G PP + +S E R ++ ++P+P+ R +A LL P Sbjct: 294 MELPHGGEGWQQ----LRQGYLPPEFTAGLSSELRSVLAMMLEPDPQLRATAEALLALPM 349 Query: 362 VNR 370 + + Sbjct: 350 LRQ 352
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 63.2 bits (152), Expect = 7e-10 Identities = 36/119 (30%), Positives = 62/119 (52%) Frame = +2 Query: 8 GSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTR 187 G +K+ADFG + C GT+ ++ PE++ + + D+WSLG E L Sbjct: 268 GELKIADFGWSVHAPSSRRTTLC-GTLDYLPPEMIEGRM-HDEKVDLWSLGVLCYEFLVG 325 Query: 188 QLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHPFV 364 + P+ + + RI + E P +++ ARD IS+ +K NP RP ++L+HP++ Sbjct: 326 KPPFEANTYQETYKRISRVEF-TFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 383
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 63.2 bits (152), Expect = 7e-10 Identities = 38/113 (33%), Positives = 61/113 (53%) Frame = +2 Query: 11 SVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQ 190 +VK+ADFGL+ + N LK+ G+ + APEV++ K GP D+WS G + ML R+ Sbjct: 190 NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRR 249 Query: 191 LPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKLL 349 LP+ D E L++ +P +S A I + + NP +R S +++ Sbjct: 250 LPFDD-ESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIM 301
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 62.8 bits (151), Expect = 9e-10 Identities = 44/148 (29%), Positives = 66/148 (44%), Gaps = 30/148 (20%) Frame = +2 Query: 8 GSVKLADFGLAKQTS-KLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 G++KLADFGLA+ L T+++ APE++ K Y A DIWS+GC EM+T Sbjct: 139 GAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT 198 Query: 185 RQLPYPDLEWTQALYRI-----------------------------GKGEPPAIPSAISK 277 R+ +P L+RI KG +P+ + Sbjct: 199 RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPN-LEP 257 Query: 278 EARDFISQCVKPNPEDRPSASKLLDHPF 361 E RD + Q ++ +P R +A L HP+ Sbjct: 258 EGRDLLMQLLQYDPSQRITAKTALAHPY 285
>TTK_MOUSE (P35761) Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK)| (PYT) Length = 856 Score = 62.8 bits (151), Expect = 9e-10 Identities = 40/135 (29%), Positives = 66/135 (48%), Gaps = 15/135 (11%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSK--LNVLKSCK-GTVYWMAPEVVNPKKT----------YGPAAD 145 +G +KL DFG+A Q +++K + GTV +MAPE + + P +D Sbjct: 656 DGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKIRTKVSPRSD 715 Query: 146 IWSLGCTVLEMLTRQLPYPDL--EWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNP 319 +WSLGC + M + P+ + + ++ I P K+ RD + C+ NP Sbjct: 716 VWSLGCILYYMTYGRTPFQHIINQVSKLHAIINPAHEIEFPEISEKDLRDVLKCCLVRNP 775 Query: 320 EDRPSASKLLDHPFV 364 ++R S +LL HP+V Sbjct: 776 KERISIPELLTHPYV 790
>MAPK3_MOUSE (Q3UMW7) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 62.8 bits (151), Expect = 9e-10 Identities = 41/130 (31%), Positives = 73/130 (56%), Gaps = 9/130 (6%) Frame = +2 Query: 14 VKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEML---- 181 +KL DFG AK+T++ N L++ T Y++APEV+ P+K Y + D+WSLG + +L Sbjct: 185 LKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGFP 242 Query: 182 -----TRQLPYPDLEWTQALYRIGKGEPPAIPSAISKEARDFISQCVKPNPEDRPSASKL 346 T Q P ++ L + P + +S++A+ I +K +P +R + + Sbjct: 243 PFYSNTGQAISPGMKRRIRLGQYSFPNPEWLD--VSEDAKQLIRLLLKTDPTERLTIMQF 300 Query: 347 LDHPFVNRSM 376 ++HP++N+SM Sbjct: 301 MNHPWINQSM 310
>M3K8_RAT (Q63562) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (Tumor progression locus 2) (TPL-2) Length = 467 Score = 62.8 bits (151), Expect = 9e-10 Identities = 45/123 (36%), Positives = 63/123 (51%), Gaps = 7/123 (5%) Frame = +2 Query: 20 LADFGLAKQ-TSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLTRQLP 196 L DFGL+ Q T + + K +GT +M+PEV+ + + ADI+SLG T++ M T P Sbjct: 268 LVDFGLSVQMTEDVYLPKDLRGTEIYMSPEVILCRG-HSTKADIYSLGATLIHMQTGTPP 326 Query: 197 ----YPDLEWTQALYRIGKGEPPA--IPSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 YP + LY I K PP I S R+ I ++ NP RP A+ LL H Sbjct: 327 WVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHE 386 Query: 359 FVN 367 +N Sbjct: 387 ALN 389
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 62.8 bits (151), Expect = 9e-10 Identities = 37/128 (28%), Positives = 65/128 (50%), Gaps = 2/128 (1%) Frame = +2 Query: 5 NGSVKLADFGLAKQTSKLNVLKSCKGTVYWMAPEVVNPKKTYGPAADIWSLGCTVLEMLT 184 N ++K+ADFGL+ K L++ G+ + +PE+VN + GP D W+LG + ++ Sbjct: 190 NCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIY 249 Query: 185 RQLPYPDLEWTQALYRIGKGE--PPAIPSAISKEARDFISQCVKPNPEDRPSASKLLDHP 358 +P+ + + +I GE P PS +AR I + NP+ R + + +H Sbjct: 250 GTMPFDGFDHKNLIRQISSGEYREPTQPS----DARGLIRWMLMVNPDRRATIEDIANHW 305 Query: 359 FVNRSMRS 382 +VN +S Sbjct: 306 WVNWGYKS 313 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 105,700,579 Number of Sequences: 219361 Number of extensions: 2398967 Number of successful extensions: 8784 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7144 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7587 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6200242422 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
