ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags31m21 |
|---|---|
| Clone Library Name | barley_pub |
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 134 bits (337), Expect = 1e-31 Identities = 72/161 (44%), Positives = 95/161 (59%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE+E+LG+V+H NL+SL GYC+ E++LVY+YM N SL L +LDW +R Sbjct: 958 FMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKR 1017 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IA+G IIH IK++N+LLD DF+ V DFGL +LIS H Sbjct: 1018 LKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISACESHVST 1077 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + GY PEY + TT DVYSFG+ILLEL +G++P Sbjct: 1078 VIAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEP 1118
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 127 bits (320), Expect = 1e-29 Identities = 73/163 (44%), Positives = 93/163 (57%), Gaps = 2/163 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH-GTHSSECLLDWRR 186 F AE+E++G+++H+NL+ L GYC G ER+LVY+YM SL LH T LDW Sbjct: 899 FMAEMETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSA 958 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 R IAIG IIH +KS+NVLLD DF A V DFG+ +L+S H Sbjct: 959 RKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDTHLS 1018 Query: 367 IIG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + GY PEY + T DVYS+G+ILLEL SG+KP Sbjct: 1019 VSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKP 1061
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 126 bits (316), Expect = 4e-29 Identities = 67/162 (41%), Positives = 94/162 (58%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE+++LGR+RH++++ L GY A+ +L+Y+YMPN SL LHG+ L W R Sbjct: 734 FTAEIQTLGRIRHRHIVRLLGYVANKDTNLLLYEYMPNGSLGELLHGSKGGH--LQWETR 791 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 +A+ + I+H +KS N+LLDSDF+AHV DFGL K + D + + Sbjct: 792 HRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLVDGAASECM 851 Query: 370 IG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY APEY K DVYSFG++LLEL +G+KP Sbjct: 852 SSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGKKP 893
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 126 bits (316), Expect = 4e-29 Identities = 72/164 (43%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE--CLLDWR 183 F AE+E++G+++H+NL+ L GYC G ER+LVY+YM SL LH S + L+W Sbjct: 900 FMAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWA 959 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 R IAIG IIH +KS+NVLLD DF+A V DFG+ +L+S H Sbjct: 960 ARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHL 1019 Query: 364 KIIG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + GY PEY + T DVYS+G+ILLEL SG+KP Sbjct: 1020 SVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKP 1063
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 125 bits (314), Expect = 6e-29 Identities = 68/164 (41%), Positives = 96/164 (58%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 FAAEVE+LG +RHK+++ L C+ G ++LVY+YMPN SL LHG +L W R Sbjct: 734 FAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPER 793 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL--ISDEIDHD 363 IA+ PI+H +KS+N+LLDSD+ A V DFG+ K+ +S + Sbjct: 794 LRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPE 853 Query: 364 KIIG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + G GY APEYV + D+YSFG++LLEL +G++P Sbjct: 854 AMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQP 897
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 125 bits (314), Expect = 6e-29 Identities = 68/161 (42%), Positives = 91/161 (56%), Gaps = 1/161 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV +L H NL+ L G+CA+G +R+LVY+YMP SL HLH S + LDW R Sbjct: 145 FVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTR 204 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL-ISDEIDHDK 366 IA G T P+I+ +K +N+LL D+Q + DFGL K+ S + H Sbjct: 205 MKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSGDKTHVS 264 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 GY AP+Y M G+ T D+YSFG++LLEL +GRK Sbjct: 265 TRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRK 305
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 125 bits (314), Expect = 6e-29 Identities = 69/161 (42%), Positives = 88/161 (54%), Gaps = 1/161 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV L + H NL++L GYCADG +R+LVY++MP SL HLH + LDW R Sbjct: 128 FLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMR 187 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL-ISDEIDHDK 366 IA G P+I+ KS+N+LLD F + DFGL KL + + H Sbjct: 188 MKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKSHVS 247 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 GY APEY M G+ T DVYSFG++ LEL +GRK Sbjct: 248 TRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRK 288
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 123 bits (308), Expect = 3e-28 Identities = 70/164 (42%), Positives = 92/164 (56%), Gaps = 4/164 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSS-ECLLDWRR 186 F E++ L R+ H +LL+L GYC DG ER+LVY++M + SL+ HLHG + + L+W R Sbjct: 548 FHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWAR 607 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 R IA+ P+IH IKS+N+L+D D A V DFGL I D Sbjct: 608 RVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLS--ILGPADSGT 665 Query: 367 IIGE---NQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 + E GY PEY TT DVYSFG++LLE+ SGRK Sbjct: 666 PLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRK 709
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 121 bits (303), Expect = 1e-27 Identities = 66/162 (40%), Positives = 94/162 (58%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE+E++G+++H+NL+ L GYC G ER+LVY+YM SL LH + L+W R Sbjct: 929 FTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPAR 988 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IAIG IIH +KS+NVLLD + +A V DFG+ +L+S H + Sbjct: 989 RKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSV 1048 Query: 370 IG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY PEY + +T DVYS+G++LLEL +G++P Sbjct: 1049 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQP 1090
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 120 bits (302), Expect = 2e-27 Identities = 65/162 (40%), Positives = 95/162 (58%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE+E++G+++H+NL+ L GYC G ER+LVY++M SL LH + L+W R Sbjct: 924 FMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTR 983 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IAIG + IIH +KS+NVLLD + +A V DFG+ +L+S H + Sbjct: 984 RKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSV 1043 Query: 370 IG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY PEY + +T DVYS+G++LLEL +G++P Sbjct: 1044 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 1085
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 120 bits (301), Expect = 2e-27 Identities = 66/161 (40%), Positives = 88/161 (54%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AEVE+L R +H NL+ LRG+C +R+L+Y YM N SL LH + LL W+ R Sbjct: 775 FEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTR 834 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IA G I+H IKS+N+LLD +F +H+ DFGL +L+S H Sbjct: 835 LRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPYETHVST 894 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY PEY T DVYSFG++LLEL + ++P Sbjct: 895 DLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKRP 935
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 120 bits (301), Expect = 2e-27 Identities = 64/160 (40%), Positives = 90/160 (56%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EVE + H+NLL LRG+C ER+LVY YM N S+ + L S+ LDW +R Sbjct: 331 FQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKR 390 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IA+G IIH +K+ N+LLD +F+A VGDFGL KL+ + H Sbjct: 391 QRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTT 450 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 G+ APEY+ GK + DV+ +G++LLEL +G++ Sbjct: 451 AVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQR 490
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 120 bits (300), Expect = 3e-27 Identities = 66/162 (40%), Positives = 93/162 (57%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE+E++G+++H+NL+ L GYC G ER+LVY+YM SL LH L+W R Sbjct: 929 FTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPAR 988 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IAIG IIH +KS+NVLLD + +A V DFG+ +L+S H + Sbjct: 989 RKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSV 1048 Query: 370 IG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY PEY + +T DVYS+G++LLEL +G++P Sbjct: 1049 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQP 1090
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 120 bits (300), Expect = 3e-27 Identities = 68/164 (41%), Positives = 93/164 (56%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE--CLLDWR 183 F AE+E+LG+++H+NL+ L GYC G ER+LVY++M SL LHG + E +L W Sbjct: 879 FMAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWE 938 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 R IA G IIH +KS+NVLLD D +A V DFG+ +LIS H Sbjct: 939 ERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHL 998 Query: 364 KIIG-ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + GY PEY + T DVYS G+++LE+ SG++P Sbjct: 999 SVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRP 1042
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 117 bits (294), Expect = 1e-26 Identities = 66/162 (40%), Positives = 94/162 (58%), Gaps = 2/162 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECL--LDWR 183 F +E+ L +VRH++L++L GYC DG E++LVY+YMP +L HL S E L L W+ Sbjct: 631 FKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLF-EWSEEGLKPLLWK 689 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 +R +A+ IH +K +N+LL D +A V DFGL++L + Sbjct: 690 QRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGSI 749 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 + GY APEY + G+ TT DVYSFG+IL+EL +GRK Sbjct: 750 ETRIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRK 791
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 116 bits (291), Expect = 3e-26 Identities = 67/161 (41%), Positives = 84/161 (52%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AEVE+L R +H NL+ L GYC +++L+Y YM N SL LH LDW+ R Sbjct: 784 FQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTR 843 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IA G I+H IKS+N+LL F AH+ DFGL +LI H Sbjct: 844 LRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPYDTHVTT 903 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY PEY T DVYSFG++LLEL +GR+P Sbjct: 904 DLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTGRRP 944
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 115 bits (287), Expect = 8e-26 Identities = 63/158 (39%), Positives = 89/158 (56%), Gaps = 1/158 (0%) Frame = +1 Query: 22 VESLGRVRHKNLLSLRG-YCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 + LGR+RH+NL+ LR Y E++L+YDY+PN SL LH + + L+W RR I Sbjct: 418 IRQLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKI 477 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A+G PIIHG+I+S NVL+D F A + +FGL K++ + + + Sbjct: 478 ALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQA 537 Query: 379 NQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 GY APE K DVY+FGI+LLE+ G+KP Sbjct: 538 KSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKP 575
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 110 bits (276), Expect = 2e-24 Identities = 61/162 (37%), Positives = 86/162 (53%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E+ L ++H+NL+ L GYC + ++ILVY +M N SL L+G S +LDW R Sbjct: 637 FDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTR 696 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID-HDK 366 IA+G +IH +KS+N+LLD A V DFG K E D + Sbjct: 697 LSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGDSYVS 756 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + GY PEY + + DV+SFG++LLE+ SGR+P Sbjct: 757 LEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREP 798
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 110 bits (276), Expect = 2e-24 Identities = 65/160 (40%), Positives = 89/160 (55%), Gaps = 2/160 (1%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTF 195 AEV LG+ H++L+ L GYC + R+LVY++MP SL HL L W+ R Sbjct: 121 AEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYFQPLSWKLRLK 180 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMK--LISDEIDHDKI 369 +A+G T +I+ K++N+LLDS++ A + DFGL K I D+ H Sbjct: 181 VALGAAKGLAFLHSSETR-VIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIGDK-SHVST 238 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 GY APEY+ G TT DVYSFG++LLEL SGR+ Sbjct: 239 RVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRR 278
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 110 bits (274), Expect = 3e-24 Identities = 68/164 (41%), Positives = 91/164 (55%), Gaps = 6/164 (3%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTF 195 AEV LG+ H NL+ L GYC + R+LVY++MP SL HL S L W R Sbjct: 122 AEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSWTLRLK 181 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK--- 366 +A+G TS +I+ K++N+LLDS++ A + DFGL K D DK Sbjct: 182 VALGAAKGLAFLHNAETS-VIYRDFKTSNILLDSEYNAKLSDFGLAK---DGPTGDKSHV 237 Query: 367 ---IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 I+G GY APEY+ G TT DVYS+G++LLE+ SGR+ Sbjct: 238 STRIMG--TYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRR 279
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 109 bits (272), Expect = 5e-24 Identities = 60/162 (37%), Positives = 86/162 (53%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E+ L ++H+NL+ L GYC + ++ILVY +M N SL L+G + +LDW R Sbjct: 636 FDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTR 695 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID-HDK 366 IA+G +IH +KS+N+LLD A V DFG K E D + Sbjct: 696 LSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQEGDSYVS 755 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + GY PEY + + DV+SFG++LLE+ SGR+P Sbjct: 756 LEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREP 797
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 104 bits (260), Expect = 1e-22 Identities = 60/168 (35%), Positives = 91/168 (54%), Gaps = 5/168 (2%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDW 180 K F AE+ +GR+ H NL+ + G+C++G R+LV +Y+ N SL A++ + LLDW Sbjct: 571 KEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSL-ANILFSEGGNILLDW 629 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLI-----S 345 R IA+G +IH +K N+LLD F+ + DFGL+KL+ + Sbjct: 630 EGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGST 689 Query: 346 DEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 + H + GY APE+V T DVYS+G++LLEL +G + Sbjct: 690 QNVSHVR----GTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTR 733
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 103 bits (256), Expect = 3e-22 Identities = 61/163 (37%), Positives = 90/163 (55%), Gaps = 6/163 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECL--LDWRRRT 192 E++ L +RH N+L+L GY G + LVY M SL A L + L L W++R Sbjct: 262 ELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRF 321 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLM----KLISDEIDH 360 I++G +P+IHG IK N+LLD Q +GDFGL+ K + ++ Sbjct: 322 SISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEV 381 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 +K+ G + Y PE+ F + +TG DVYSFGI+LLE+ +GR+ Sbjct: 382 NKVFG--TKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQ 422
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 101 bits (252), Expect = 1e-21 Identities = 60/167 (35%), Positives = 88/167 (52%), Gaps = 9/167 (5%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTF 195 AE+ LG++ H NL+ L GYC + R+LVY++M SL HL + L W R Sbjct: 121 AEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVR 180 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIG 375 +A+G +I+ K++N+LLDS++ A + DFGL + D +G Sbjct: 181 MALGAARGLAFLHNAQPQ-VIYRDFKASNILLDSNYNAKLSDFGLAR--------DGPMG 231 Query: 376 ENQ---------RGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 +N +GY APEY+ G + DVYSFG++LLEL SGR+ Sbjct: 232 DNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRR 278
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 100 bits (250), Expect = 2e-21 Identities = 55/161 (34%), Positives = 89/161 (55%), Gaps = 1/161 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV + R++H NL+ + G C +G E++L+Y+Y+ N SL ++L G + L+W R Sbjct: 569 FMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFG-KTRRSKLNWNER 627 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLIS-DEIDHDK 366 I G IIH +K +N+LLD + + DFG+ ++ DE + + Sbjct: 628 FDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERDETEANT 687 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 + GY +PEY M+G + DV+SFG+I+LE+ SG+K Sbjct: 688 MKVVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKK 728
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 99.4 bits (246), Expect = 5e-21 Identities = 58/160 (36%), Positives = 86/160 (53%), Gaps = 3/160 (1%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E+E++G+VRH+NL+ L + +++Y YM N SL LH T+ + L DW R I Sbjct: 861 EIETIGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPL-DWSTRHNI 919 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLI---SDEIDHDKI 369 A+G I+H IK N+LLDSD + H+ DFG+ KL+ + I + + Sbjct: 920 AVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSATSIPSNTV 979 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 G GY APE + DVYS+G++LLEL + +K Sbjct: 980 QG--TIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKK 1017
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 98.6 bits (244), Expect = 8e-21 Identities = 58/157 (36%), Positives = 84/157 (53%), Gaps = 1/157 (0%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTF 195 +EV LG + H+NL+ L GYC + E +LVY++MP SL +HL + W R Sbjct: 139 SEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRNDP---FPWDLRIK 195 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL-ISDEIDHDKII 372 I IG +I+ K++N+LLDS++ A + DFGL KL +DE H Sbjct: 196 IVIGAARGLAFLHSLQRE-VIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEKSHVTTR 254 Query: 373 GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSG 483 GY APEY+ G DV++FG++LLE+ +G Sbjct: 255 IMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTG 291
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 97.4 bits (241), Expect = 2e-20 Identities = 58/160 (36%), Positives = 81/160 (50%), Gaps = 1/160 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AEV+ L RV H NL SL GYC + +L+Y+YM N +L +L G S +L W R Sbjct: 614 FRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRS--FILSWEER 671 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDE-IDHDK 366 I++ PI+H +K TN+LL+ QA + DFGL + S E Sbjct: 672 LKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQIS 731 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGR 486 + GY PEY + DVYS G++LLE+ +G+ Sbjct: 732 TVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQ 771
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 94.4 bits (233), Expect = 2e-19 Identities = 59/171 (34%), Positives = 81/171 (47%), Gaps = 8/171 (4%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDW 180 K F EVE L R RH N++ GYCA LVY ++PN SL LH + L W Sbjct: 253 KQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSW 312 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGL---MKLISDE 351 +R I +G S +IHG IKS+NVLLD +GDFGL + Sbjct: 313 PQRLDILLGTARAIQFLHQDSPS-LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSS 371 Query: 352 IDHDKIIGENQ--RG---YHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 ++ Q RG Y EY+ G+ D +SFG+++LE +G++ Sbjct: 372 PSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQR 422
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 94.0 bits (232), Expect = 2e-19 Identities = 58/171 (33%), Positives = 81/171 (47%), Gaps = 8/171 (4%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDW 180 K F EVE L R RH N++ GYCA+ LVY ++PN SL LH + L W Sbjct: 253 KQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSW 312 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGL---MKLISDE 351 +R I +G S +IHG IKS+NVLLD +GDFGL + + Sbjct: 313 PQRLDILLGTARAIQFLHQDSPS-LIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAK 371 Query: 352 IDHDKIIGENQ--RG---YHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 + RG Y EY+ G+ D +SFG+++LE +G++ Sbjct: 372 ASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQR 422
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 89.0 bits (219), Expect = 6e-18 Identities = 60/169 (35%), Positives = 84/169 (49%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECL--- 171 K F E++ + +H+NL+ L G+ +D LVY YMPN SL L CL Sbjct: 227 KQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRL------SCLDGT 280 Query: 172 --LDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL-- 339 L W R +A G + IH IKS N+LLD DF A + DFGL + Sbjct: 281 PPLSWHTRCKVAQG---TANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLARASA 337 Query: 340 -ISDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSG 483 ++ + +I+G Y APE + G+ T D+YSFG++LLEL +G Sbjct: 338 RLAQTVMTSRIVGTT--AYMAPE-ALRGEITPKSDIYSFGVVLLELITG 383
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 88.6 bits (218), Expect = 8e-18 Identities = 60/169 (35%), Positives = 85/169 (50%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECL--- 171 K F E++ + + +H+NL+ L G+ +DG + LVY YMPN SL L CL Sbjct: 227 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRL------SCLDGT 280 Query: 172 --LDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL-- 339 L W R IA G + IH IKS N+LLD F A + DFGL + Sbjct: 281 PPLSWHMRCKIAQG---AANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE 337 Query: 340 -ISDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSG 483 + + +I+G Y APE + G+ T D+YSFG++LLE+ +G Sbjct: 338 KFAQTVMTSRIVGTT--AYMAPE-ALRGEITPKSDIYSFGVVLLEIITG 383
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 77.4 bits (189), Expect = 2e-14 Identities = 50/165 (30%), Positives = 74/165 (44%), Gaps = 5/165 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E+E L RH ++L L Y + + LVY YM N +LF L T+ + L W R Sbjct: 222 FLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGT-TPLSWHVR 280 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IG +I G++ S N+LLD Q + DF + Sbjct: 281 ISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSST 340 Query: 370 I-----GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRK 489 I G Y EY+ G+ + DVYSFGI+++E+ +G K Sbjct: 341 INMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCK 385
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 77.0 bits (188), Expect = 3e-14 Identities = 52/164 (31%), Positives = 73/164 (44%), Gaps = 6/164 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E+E L H N+L L Y + + L+Y YM N +LF L + L W R Sbjct: 209 FLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDT-APLPWHIR 267 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 I IG +I GSI S N+LLD FQ + DF + S ++H Sbjct: 268 IGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRS-HLEHQSC 326 Query: 370 I------GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSG 483 Y EY+ GK + DVYSFGI+++E+ +G Sbjct: 327 TINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 71.6 bits (174), Expect = 1e-12 Identities = 51/161 (31%), Positives = 75/161 (46%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV + R+RH N++ G P +V +Y+ SL+ LH + + E LD RRR Sbjct: 593 FLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGARE-QLDERRR 651 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 +A PI+H +KS N+L+D + V DFGL +L + K Sbjct: 652 LSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKS 710 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + DVYSFG+IL EL + ++P Sbjct: 711 AAGTPE-WMAPEVLRDEPSNEKSDVYSFGVILWELATLQQP 750
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 65.5 bits (158), Expect = 8e-11 Identities = 45/159 (28%), Positives = 77/159 (48%), Gaps = 1/159 (0%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E+ L + H+N++ + G ++G + L+ +Y+ SL +L+G E ++ R + Sbjct: 54 EITHLSEIDHENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWAL 113 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQ-AHVGDFGLMKLISDEIDHDKIIG 375 PI+H IK N+LL + + + DFGL + ++ ++K Sbjct: 114 QCAKALAYLHSLDR---PIVHRDIKPQNMLLYNQHEDLKICDFGL----ATDMSNNKTDM 166 Query: 376 ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + Y APE + K T CDVYSFGI+L EL + + P Sbjct: 167 QGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMTRQLP 205
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 65.1 bits (157), Expect = 1e-10 Identities = 45/173 (26%), Positives = 82/173 (47%), Gaps = 12/173 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 585 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 644 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 R+ +G + + +H + + N L+ ++ +GDFG+ + + Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV 704 Query: 343 SDEIDHDKIIGENQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+SFG+IL E+ T G++P Sbjct: 705 Y-STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 65.1 bits (157), Expect = 1e-10 Identities = 45/173 (26%), Positives = 82/173 (47%), Gaps = 12/173 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 585 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 644 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 R+ +G + + +H + + N L+ ++ +GDFG+ + + Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV 704 Query: 343 SDEIDHDKIIGENQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+SFG+IL E+ T G++P Sbjct: 705 Y-STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 65.1 bits (157), Expect = 1e-10 Identities = 45/173 (26%), Positives = 82/173 (47%), Gaps = 12/173 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 587 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 646 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 R+ +G + + +H + + N L+ ++ +GDFG+ + + Sbjct: 647 RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV 706 Query: 343 SDEIDHDKIIGENQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+SFG+IL E+ T G++P Sbjct: 707 Y-STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 758
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 64.3 bits (155), Expect = 2e-10 Identities = 45/173 (26%), Positives = 82/173 (47%), Gaps = 12/173 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 585 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 644 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 R+ +G + + +H + + N L+ ++ +GDFG+ + + Sbjct: 645 RQAKGELGLSQMLHIASQICSGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV 704 Query: 343 SDEIDHDKIIGENQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+SFG+IL E+ T G++P Sbjct: 705 Y-STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G G ++V +YM N SL L TH + + Sbjct: 681 FLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR-THDGQFTIMQLVG 739 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID--HD 363 +G +H + + NVL+DS+ V DFGL +++ D+ D + Sbjct: 740 MLRGVGAGMRYLSDLGY-----VHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYT 794 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 G+ + APE + F ++ DV+SFG+++ E L G +P Sbjct: 795 TTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERP 838
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 63.2 bits (152), Expect = 4e-10 Identities = 49/164 (29%), Positives = 76/164 (46%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSSECLLDWRR 186 F EV L ++ H ++ G C D P + +V Y+ SLF+ LH + +LD + Sbjct: 505 FCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLH---EQKRILDLQS 561 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 + IA+ T PIIH + S N+LL D A V DFG + + +D D Sbjct: 562 KLIIAVDVAKGMEYLHSL-TQPIIHRDLNSHNILLYEDGHAVVADFGESRFL-QSLDEDN 619 Query: 367 IIGE-NQRGYHAPE-YVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + + + APE + + T DV+S+ + L EL +G P Sbjct: 620 MTKQPGNLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLTGEIP 663
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 63.2 bits (152), Expect = 4e-10 Identities = 43/159 (27%), Positives = 80/159 (50%), Gaps = 4/159 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERIL--VYDYMPNSSLFAHLHGTHSSECLLDWR 183 F E+E L ++H N++ +G C R L + +Y+P SL +L H +D + Sbjct: 895 FEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKER--IDHK 951 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 + + T IH + + N+L++++ + +GDFGL K++ + ++ Sbjct: 952 K---LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY 1008 Query: 364 KI--IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL 474 K+ GE+ ++APE + K + DV+SFG++L EL Sbjct: 1009 KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL 1047 Score = 40.0 bits (92), Expect = 0.003 Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F + ++ HK+L+ G C G E ILV +++ SL +L +S +L W+ Sbjct: 594 FFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINIL-WK-- 650 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID---H 360 + + S +IHG++ + N+LL + G+ +KL I Sbjct: 651 --LGVAKQLAWAMHFLEEKS-LIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVL 707 Query: 361 DKIIGENQRGYHAPEYVMFGKP-TTGCDVYSFGIILLELTSG 483 K I + + + PE + K T D +SFG L E+ SG Sbjct: 708 PKDILQERIPWVPPECIENPKNLTLATDKWSFGTTLWEICSG 749
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 62.8 bits (151), Expect = 5e-10 Identities = 43/160 (26%), Positives = 74/160 (46%), Gaps = 2/160 (1%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH--SSECLLDWRRRT 192 +++ L +++H N+++ +G C P ++ +Y + L+ L + L+DW T Sbjct: 204 DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWS--T 261 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 IA G IIH +KS NVL+ + DFG K +SD+ K+ Sbjct: 262 GIASGMNYLHLHK-------IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--STKMS 312 Query: 373 GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + + D++SFG++L EL +G P Sbjct: 313 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 352
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 62.4 bits (150), Expect = 6e-10 Identities = 43/160 (26%), Positives = 74/160 (46%), Gaps = 2/160 (1%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH--SSECLLDWRRRT 192 +++ L +++H N+++ +G C P ++ +Y + L+ L + L+DW T Sbjct: 204 DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWS--T 261 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 IA G IIH +KS NVL+ + DFG K +SD+ K+ Sbjct: 262 GIASGMNYLHLHK-------IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--STKMS 312 Query: 373 GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + + D++SFG++L EL +G P Sbjct: 313 FAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 352
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 62.0 bits (149), Expect = 8e-10 Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSSECLLDWRR 186 F EV L ++ H ++ G C D P + +V Y+ SLF+ LH + +LD + Sbjct: 504 FCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLH---EQKRILDLQS 560 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 + IA+ T PIIH + S N+LL D A V DFG + + +D D Sbjct: 561 KLIIAVDVAKGMEYLHSL-TQPIIHRDLNSHNILLYEDGHAVVADFGESRFL-QSLDEDN 618 Query: 367 IIGE-NQRGYHAPE-YVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + + + APE + + T DV+S+ + L EL G P Sbjct: 619 MTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLIGEIP 662
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 62.0 bits (149), Expect = 8e-10 Identities = 44/163 (26%), Positives = 80/163 (49%), Gaps = 8/163 (4%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERIL--VYDYMPNSSLFAHLHGTHSSEC----L 171 F E+E L ++H N++ +G C R L + +Y+P SL +L H L Sbjct: 895 FEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKERIDHIKL 953 Query: 172 LDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDE 351 L + + + T IH + + N+L++++ + +GDFGL K++ + Sbjct: 954 LQYTSQICKGM---------EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD 1004 Query: 352 IDHDKI--IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL 474 ++ K+ GE+ ++APE + K + DV+SFG++L EL Sbjct: 1005 KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL 1047 Score = 37.0 bits (84), Expect = 0.029 Identities = 39/162 (24%), Positives = 66/162 (40%), Gaps = 4/162 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F + ++ HK+L+ G C G E ILV +++ SL +L + +L W+ Sbjct: 594 FFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINIL-WKLE 652 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID---H 360 + +IHG++ + N+LL + G+ +KL I Sbjct: 653 V-----AKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVL 707 Query: 361 DKIIGENQRGYHAPEYVMFGKP-TTGCDVYSFGIILLELTSG 483 K I + + + PE + K D +SFG L E+ SG Sbjct: 708 PKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 62.0 bits (149), Expect = 8e-10 Identities = 42/159 (26%), Positives = 80/159 (50%), Gaps = 4/159 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERIL--VYDYMPNSSLFAHLHGTHSSECLLDWR 183 F E+E L ++H N++ +G C R L + +Y+P SL +L H +D + Sbjct: 895 FEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKER--IDHK 951 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 + + T IH + + N+L++++ + +GDFGL K++ + ++ Sbjct: 952 K---LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY 1008 Query: 364 KI--IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL 474 K+ GE+ ++AP+ + K + DV+SFG++L EL Sbjct: 1009 KVKEPGESPIFWYAPQSLTESKFSVASDVWSFGVVLYEL 1047 Score = 38.5 bits (88), Expect = 0.010 Identities = 41/162 (25%), Positives = 69/162 (42%), Gaps = 4/162 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F + ++ HK+L+ G C G E ILV +++ SL +L +S +L W+ Sbjct: 594 FFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINIL-WK-- 650 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID---H 360 + + S +IHG++ + N+LL + G+ +KL I Sbjct: 651 --LGVAKQLAWAMHFLEEKS-LIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVL 707 Query: 361 DKIIGENQRGYHAPEYVMFGKP-TTGCDVYSFGIILLELTSG 483 K I + + + PE + K D +SFG L E+ SG Sbjct: 708 PKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 61.6 bits (148), Expect = 1e-09 Identities = 45/162 (27%), Positives = 74/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RHK L+ L ++ P I++ +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHKKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 60.8 bits (146), Expect = 2e-09 Identities = 33/84 (39%), Positives = 53/84 (63%), Gaps = 4/84 (4%) Frame = +1 Query: 253 IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDE---IDHDKIIGENQRGYHAPEYVMFGK 423 ++H +K +N+++D D Q + DFGL K ++D+ + K++G + Y APE ++ G+ Sbjct: 240 LVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLVGTYR--YMAPEQIL-GE 296 Query: 424 PTTG-CDVYSFGIILLELTSGRKP 492 P G D+YS G+IL EL SGR P Sbjct: 297 PLDGRADLYSLGVILYELLSGRPP 320
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 60.8 bits (146), Expect = 2e-09 Identities = 43/173 (24%), Positives = 80/173 (46%), Gaps = 12/173 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 585 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 644 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 + +G + + +H + + N + ++ +GDFG+ + + Sbjct: 645 XQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCXVGANLLVKIGDFGMSRDV 704 Query: 343 SDEIDHDKIIGENQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+SFG+IL E+ T G++P Sbjct: 705 Y-STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 60.5 bits (145), Expect = 2e-09 Identities = 46/164 (28%), Positives = 73/164 (44%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G G ++V +YM N SL A L TH + + Sbjct: 680 FLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLR-THDGQFTIVQLVG 738 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDHD 363 +G IH + + NVL+D V DFGL + + D E + Sbjct: 739 MLRGVGAGMRYLSDLG-----YIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYT 793 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 G+ + APE + F ++ DV+SFG+++ E L G +P Sbjct: 794 TAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERP 837
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 60.5 bits (145), Expect = 2e-09 Identities = 46/162 (28%), Positives = 70/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++RH L+ L C +V + M + SL +L G S L D Sbjct: 280 FLEEASIMKQLRHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYLRGDGRSLKLPD---- 335 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH + + N+L+ V DFGL ++I +EI K+ Sbjct: 336 --LVDMCSQVASGMSYLEQQNYIHRDLAARNILVGEHKICKVADFGLARVIDEEIYEAKL 393 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 + + APE M+ + T DV+SFGI+L E +T GR P Sbjct: 394 GAKFPIKWTAPEAAMYSRFTIKSDVWSFGIVLYEVITYGRFP 435
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 60.5 bits (145), Expect = 2e-09 Identities = 47/164 (28%), Positives = 76/164 (46%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSSECLLDWRR 186 F EV L ++ H ++ G C + P + +V Y+ SLF+ LH + +LD + Sbjct: 607 FCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH---EQKRILDLQS 663 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 + IA+ T PIIH + S N+LL D A V DFG + + +D D Sbjct: 664 KLIIAVDVAKGMEYLHNL-TQPIIHRDLNSHNILLYEDGHAVVADFGESRFL-QSLDEDN 721 Query: 367 IIGE-NQRGYHAPE-YVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + + + APE + + T DV+S+ + L E+ +G P Sbjct: 722 MTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIP 765
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/187 (24%), Positives = 84/187 (44%), Gaps = 26/187 (13%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 585 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 644 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 R+ +G + + +H + + N L+ ++ +GDFG+ + + Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV 704 Query: 343 SDEIDHDKIIGEN--------QRGYHA--------PEYVMFGKPTTGCDVYSFGIILLEL 474 D+ ++ + + G H PE +M+ K TT DV+SFG+IL E+ Sbjct: 705 Y-STDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 763 Query: 475 -TSGRKP 492 T G++P Sbjct: 764 FTYGKQP 770
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 60.1 bits (144), Expect = 3e-09 Identities = 48/167 (28%), Positives = 79/167 (47%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E +G+ H N++ L G G ++V +YM N +L A L G + L+ Sbjct: 674 FLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGM 733 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EI 354 R IA G +H + + N+L++S+ V DFGL ++I D E Sbjct: 734 LRG--IAAGMRYLADMG-------YVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEA 784 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 785 VYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 831
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 60.1 bits (144), Expect = 3e-09 Identities = 44/162 (27%), Positives = 74/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I++ +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 60.1 bits (144), Expect = 3e-09 Identities = 44/162 (27%), Positives = 74/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I++ +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 60.1 bits (144), Expect = 3e-09 Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 9/167 (5%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH-SSECLLDWRRRTF 195 E G ++H N+++LRG C + P LV +Y +L L G L++W Sbjct: 145 EARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNW----- 199 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAH--------VGDFGLMKLISDE 351 A+ PIIH +KS N+L+ + H + DFGL + + Sbjct: 200 -AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EW 255 Query: 352 IDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 K+ + APE + + DV+SFG++L EL +G P Sbjct: 256 HKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVP 302
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 59.7 bits (143), Expect = 4e-09 Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I++ +YM SL L G + R Sbjct: 303 FLQEAQVMKKLRHEKLVQLYAMVSEEPIYIVI-EYMSKGSLLDFLKGEMGK-----YLRL 356 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 357 PQLVEMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARP 416 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 417 GARFPVKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 458
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 59.7 bits (143), Expect = 4e-09 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++RHK+L+ L C+D +V +YM SL +L L Sbjct: 280 FLDEAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLP---- 335 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 T I + IH + + N+L+ ++ V DFGL +LI D+ Sbjct: 336 TLIDMAAQVASGMAFLEAQG-YIHRDLAARNILVGENYICKVADFGLARLIEDDEYTAHE 394 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++ + T DV+SFGI++ E+ T GR P Sbjct: 395 GAKFPIKWTAPEAALYNRFTIKSDVWSFGILMAEIVTKGRIP 436
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 59.7 bits (143), Expect = 4e-09 Identities = 39/161 (24%), Positives = 71/161 (44%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE+ L ++H N+++ G C P +V +YM +L L + + + + + Sbjct: 1406 FRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLK---NPDIKITFANK 1462 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + G I+H IK N+L+D F + DFG ++ D + Sbjct: 1463 LKLLYGAAMGIDYLHSSNPM-IVHRDIKPANILVDEHFNVKIADFGFARIKEDNTTMTRC 1521 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + K DV+SFG+++ E+ +G++P Sbjct: 1522 ---GTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKEP 1559 Score = 56.6 bits (135), Expect = 4e-08 Identities = 51/167 (30%), Positives = 76/167 (45%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV+ + +RH N++ P +V ++M SL+ L E + + + Sbjct: 828 FFEEVKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPE--IPYALK 885 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID---- 357 +A +S I+H +KS N+LLDS + V DFGL K + E+D Sbjct: 886 IKMAY---QASKGMHFLHSSGIVHRDLKSLNLLLDSKWNVKVSDFGLTK-VKSELDKKKT 941 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTG--CDVYSFGIILLELTSGRKP 492 +D IIG + APE + DVYSFGIIL EL + +P Sbjct: 942 NDNIIGTIH--WIAPEILNDSTEVDYILADVYSFGIILWELLTREQP 986
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 75/162 (46%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + RH L++L C+ +V +YM SL L L + Sbjct: 324 FLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLR--EGDGRYLHFEDL 381 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 +IA + +IH + + NVL+ + A + DFGL ++I+D+ K Sbjct: 382 IYIA---TQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQ 438 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + APE +++GK + DV+S+GI+L+EL T G+ P Sbjct: 439 GSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVP 480
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 309 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGETGK-----YLRL 362 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 363 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 422 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 423 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 464
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 58.9 bits (141), Expect = 7e-09 Identities = 42/165 (25%), Positives = 75/165 (45%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G ++V +YM N SL L ++ Sbjct: 723 FLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQ---- 778 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFGL +++ D E + Sbjct: 779 ---LVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 835 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + F K T+ DV+S+GI++ E+ S G +P Sbjct: 836 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERP 880
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 58.9 bits (141), Expect = 7e-09 Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE---CLLDW 180 F EV L + RH N+L GY P+ +V + SSL+ HLH + L+D Sbjct: 108 FKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 166 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL---ISDE 351 R+T IIH +KS N+ L D +GDFGL + S Sbjct: 167 ARQT---------AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS 217 Query: 352 IDHDKIIGENQRGYHAPEYVMF---GKPTTGCDVYSFGIILLELTSGRKP 492 +++ G + APE + + DVY+FGI+L EL +G+ P Sbjct: 218 HQFEQLSGSIL--WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 265
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 58.9 bits (141), Expect = 7e-09 Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE---CLLDW 180 F EV L + RH N+L GY P+ +V + SSL+ HLH + L+D Sbjct: 538 FKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 596 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL---ISDE 351 R+T IIH +KS N+ L D +GDFGL + S Sbjct: 597 ARQT---------AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS 647 Query: 352 IDHDKIIGENQRGYHAPEYVMF---GKPTTGCDVYSFGIILLELTSGRKP 492 +++ G + APE + + DVY+FGI+L EL +G+ P Sbjct: 648 HQFEQLSGSIL--WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 695
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 58.9 bits (141), Expect = 7e-09 Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE---CLLDW 180 F EV L + RH N+L GY P+ +V + SSL+ HLH + L+D Sbjct: 538 FKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 596 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL---ISDE 351 R+T IIH +KS N+ L D +GDFGL + S Sbjct: 597 ARQT---------AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS 647 Query: 352 IDHDKIIGENQRGYHAPEYVMF---GKPTTGCDVYSFGIILLELTSGRKP 492 +++ G + APE + + DVY+FGI+L EL +G+ P Sbjct: 648 HQFEQLSGSIL--WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 695
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 58.9 bits (141), Expect = 7e-09 Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE---CLLDW 180 F EV L + RH N+L GY P+ +V + SSL+ HLH + L+D Sbjct: 124 FKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 182 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL---ISDE 351 R+T IIH +KS N+ L D +GDFGL + S Sbjct: 183 ARQT---------AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS 233 Query: 352 IDHDKIIGENQRGYHAPEYVMF---GKPTTGCDVYSFGIILLELTSGRKP 492 +++ G + APE + + DVY+FGI+L EL +G+ P Sbjct: 234 HQFEQLSGSIL--WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 281
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 58.9 bits (141), Expect = 7e-09 Identities = 47/165 (28%), Positives = 71/165 (43%), Gaps = 7/165 (4%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE++ R H N+L + G+CA +Y YM N SL L G S+ L W +R Sbjct: 254 FQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSD-PLPWPQR 312 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDF-------QAHVGDFGLMKLISD 348 I G IIH ++KS+NVLLD + AH+ + Sbjct: 313 VSICSGLLCAVEYLHGL---EIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTM 369 Query: 349 EIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSG 483 H + Y +++ G+ T D++S GI+L E+ +G Sbjct: 370 MKTH---LLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTG 411
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 58.9 bits (141), Expect = 7e-09 Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE---CLLDW 180 F EV L + RH N+L GY P+ +V + SSL+ HLH + L+D Sbjct: 498 FKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 556 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL---ISDE 351 R+T IIH +KS N+ L D +GDFGL + S Sbjct: 557 ARQT---------AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS 607 Query: 352 IDHDKIIGENQRGYHAPEYVMF---GKPTTGCDVYSFGIILLELTSGRKP 492 +++ G + APE + + DVY+FGI+L EL +G+ P Sbjct: 608 HQFEQLSGSIL--WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 655
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 58.9 bits (141), Expect = 7e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 309 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMNKGSLLDFLKGETGK-----YLRL 362 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 363 PQLVDMSAQIASGMAYVDRMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 422 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 423 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 464
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 58.9 bits (141), Expect = 7e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 305 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGR-----YLRL 358 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 359 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 418 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 419 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 460
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 58.9 bits (141), Expect = 7e-09 Identities = 42/156 (26%), Positives = 79/156 (50%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCA-DGPERI-LVYDYMPNSSLFAHLHGTHSSECLLDWRRRT 192 E+E L + H+N++ +G C DG I L+ +++P+ SL +L + ++ +++ Sbjct: 913 EIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK---INLKQQL 969 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 A+ + +H + + NVL++S+ Q +GDFGL K I + ++ + Sbjct: 970 KYAV---QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVK 1026 Query: 373 GENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL 474 + ++APE +M K DV+SFG+ L EL Sbjct: 1027 DDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHEL 1062 Score = 29.6 bits (65), Expect = 4.6 Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 5/160 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F + +V HK+++ L G C E I+V +++ L +H S W+ + Sbjct: 623 FFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH-RKSDVLTTPWKFK 681 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSD-FQAHVGDFGLMKLISDEIDHDK 366 ++HG++ + N+LL + + G F +KL I Sbjct: 682 V-----AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPF--IKLSDPGIPITV 734 Query: 367 IIGE---NQRGYHAPEYVMFGKP-TTGCDVYSFGIILLEL 474 + + + + APE V K + D +SFG L E+ Sbjct: 735 LSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI 774
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 58.9 bits (141), Expect = 7e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 306 FLQEAQVMKKLRHEKLVRLYAVVSEEPIYI-VTEYMSKGSLLDFLKGEMGK-----YLRL 359 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 360 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 419 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 420 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 461
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 58.9 bits (141), Expect = 7e-09 Identities = 45/164 (27%), Positives = 72/164 (43%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G G ++V +YM N SL A L TH + + Sbjct: 48 FLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLR-THDGQFTILQLVG 106 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDHD 363 +G IH + + N+L+D V DFGL + + D E + Sbjct: 107 MLKGVGAGMRYLSDLG-----YIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYT 161 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 G+ + APE + F ++ DV+SFG+++ E L G +P Sbjct: 162 TAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERP 205
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 58.9 bits (141), Expect = 7e-09 Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSE---CLLDW 180 F EV L + RH N+L GY P+ +V + SSL+ HLH + L+D Sbjct: 60 FKNEVGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 118 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKL---ISDE 351 R+T IIH +KS N+ L D +GDFGL + S Sbjct: 119 ARQT---------AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS 169 Query: 352 IDHDKIIGENQRGYHAPEYVMF---GKPTTGCDVYSFGIILLELTSGRKP 492 +++ G + APE + + DVY+FGI+L EL +G+ P Sbjct: 170 HQFEQLSGSIL--WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 217
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 58.9 bits (141), Expect = 7e-09 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +YM SL L G + R Sbjct: 314 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMNKGSLLDFLKGETGK-----YLRL 367 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 368 PQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 427 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 428 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 469
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 58.9 bits (141), Expect = 7e-09 Identities = 48/168 (28%), Positives = 74/168 (44%), Gaps = 10/168 (5%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHG-THSSECLLDWRRRTF 195 E E L + R +L + G C + +V +YMPN SL LH T + R R Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125 Query: 196 --IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 IA+G T P++H +K+ N+LLD++F + DFGL K + + Sbjct: 126 HEIALGVNYLHNM-----TPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS 180 Query: 370 IGENQRG----YHAPEYVMFGKPTTGC---DVYSFGIILLELTSGRKP 492 G Y PE G+ + D+YS+ +I E+ S ++P Sbjct: 181 SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQP 228
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 58.9 bits (141), Expect = 7e-09 Identities = 48/163 (29%), Positives = 73/163 (44%), Gaps = 5/163 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E + +++ ++++S+ G C +V ++M N SL L THS L W+ R F Sbjct: 71 EAAKMKKIKFQHIVSIYGVCKQPLG--IVMEFMANGSLEKVL-STHS----LCWKLR-FR 122 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 I P++H +K N+LLDS+ + DFGL K + I Sbjct: 123 IIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERS 182 Query: 379 NQRG---YHAPEYVMFGKPTTG--CDVYSFGIILLELTSGRKP 492 RG Y PE + G DVYSF I++ EL + +KP Sbjct: 183 ALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKP 225
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 58.5 bits (140), Expect = 9e-09 Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL + L H ++ Sbjct: 667 FLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLR-KHDAQF------- 718 Query: 190 TFIAIGXXXXXXXXXXXXTSPI--IHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EID 357 T I + S + +H + + N+L++S+ V DFGL +++ D E Sbjct: 719 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 778 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + +PE + + K T+ DV+S+GI+L E+ S G +P Sbjct: 779 YTTRGGKIPIRWTSPEAMSYRKFTSASDVWSYGIVLWEVMSYGERP 824
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 58.5 bits (140), Expect = 9e-09 Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 7/165 (4%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E E L + R +L + G C + +V +YMPN SL LH + W R F Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIA-WPLR-FR 123 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 + P++H +K+ N+LLD++F + DFGL K + + Sbjct: 124 ILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKS 183 Query: 379 NQRG----YHAPEYVMFGKPTTGC---DVYSFGIILLELTSGRKP 492 G Y PE G+ + D+YS+ +I+ E+ S ++P Sbjct: 184 APEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQP 228
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 58.5 bits (140), Expect = 9e-09 Identities = 41/160 (25%), Positives = 73/160 (45%), Gaps = 2/160 (1%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH--SSECLLDWRRRT 192 +++ L +++H N+++ +G C P ++ ++ L+ L + L+DW Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG- 219 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 IA G IIH +KS N+L+ D + DFG K +SD+ K+ Sbjct: 220 -IAGGMNYLHLHK-------IIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--STKMS 269 Query: 373 GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + + D++SFG++L EL +G P Sbjct: 270 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 309
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 58.5 bits (140), Expect = 9e-09 Identities = 41/160 (25%), Positives = 73/160 (45%), Gaps = 2/160 (1%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH--SSECLLDWRRRT 192 +++ L +++H N+++ +G C P ++ ++ L+ L + L+DW Sbjct: 194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG- 252 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 IA G IIH +KS N+L+ D + DFG K +SD+ K+ Sbjct: 253 -IAGGMNYLHLHK-------IIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--STKMS 302 Query: 373 GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + + D++SFG++L EL +G P Sbjct: 303 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 342
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 58.5 bits (140), Expect = 9e-09 Identities = 41/160 (25%), Positives = 73/160 (45%), Gaps = 2/160 (1%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH--SSECLLDWRRRT 192 +++ L +++H N+++ +G C P ++ ++ L+ L + L+DW Sbjct: 194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG- 252 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 IA G IIH +KS N+L+ D + DFG K +SD+ K+ Sbjct: 253 -IAGGMNYLHLHK-------IIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--STKMS 302 Query: 373 GENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + + D++SFG++L EL +G P Sbjct: 303 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 342
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 58.5 bits (140), Expect = 9e-09 Identities = 44/163 (26%), Positives = 68/163 (41%), Gaps = 2/163 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH--GTHSSECLLDWR 183 F E +S+ R+ H N++ + DG L +Y+ +L L G LD Sbjct: 63 FIREAKSVARLAHPNVVQVFDQGTDGAYVYLAMEYIAGCTLRDVLRERGALQPRAALDIL 122 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 A+G +H +K NVL+ D + V DFGL++ + D + + Sbjct: 123 EPVLAALGAAHRAG---------FVHRDMKPENVLIGDDGRVKVADFGLVRAV-DSVTNT 172 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 Y APE + G DVY+ GI+L E+ +G KP Sbjct: 173 TGTVLGTVSYLAPEQIEHGTADPRVDVYACGILLYEMLTGEKP 215
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 58.5 bits (140), Expect = 9e-09 Identities = 47/167 (28%), Positives = 79/167 (47%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E +G+ H N++ L G G ++V ++M N +L A L G + L+ Sbjct: 679 FLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGM 738 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EI 354 R IA G +H + + N+L++S+ V DFGL ++I D E Sbjct: 739 LRG--IAAGMRYLADMGY-------VHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEA 789 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 790 VYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 836
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 58.5 bits (140), Expect = 9e-09 Identities = 47/167 (28%), Positives = 79/167 (47%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E +G+ H N++ L G G ++V ++M N +L A L G + L+ Sbjct: 679 FLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGM 738 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EI 354 R IA G +H + + N+L++S+ V DFGL ++I D E Sbjct: 739 LRG--IAAGMRYLADMGY-------VHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEA 789 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 790 VYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 836
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 58.5 bits (140), Expect = 9e-09 Identities = 47/167 (28%), Positives = 79/167 (47%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E +G+ H N++ L G G ++V ++M N +L A L G + L+ Sbjct: 679 FLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGM 738 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EI 354 R IA G +H + + N+L++S+ V DFGL ++I D E Sbjct: 739 LRG--IAAGMRYLADMGY-------VHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEA 789 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 790 VYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 836
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 58.5 bits (140), Expect = 9e-09 Identities = 44/161 (27%), Positives = 72/161 (44%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +EV L R+ H N++ C P ++ +YM +L +L+ ++ R Sbjct: 132 FKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLR 191 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + I + +IH +KS N+LL+ + + V DFG L + + Sbjct: 192 LALDISRGMEYLH-----SQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGN 246 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 +G + + APE + T DVYSFGI+L ELT+ P Sbjct: 247 MGTYR--WMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLP 285
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 58.5 bits (140), Expect = 9e-09 Identities = 42/165 (25%), Positives = 74/165 (44%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL L ++ Sbjct: 560 FLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQ---- 615 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFGL +++ D E + Sbjct: 616 ---LVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 672 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + F K T+ DV+S+GI++ E+ S G +P Sbjct: 673 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERP 717
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 58.5 bits (140), Expect = 9e-09 Identities = 42/165 (25%), Positives = 74/165 (44%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL L ++ Sbjct: 721 FLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQ---- 776 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFGL +++ D E + Sbjct: 777 ---LVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 833 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + F K T+ DV+S+GI++ E+ S G +P Sbjct: 834 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERP 878
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 58.2 bits (139), Expect = 1e-08 Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL + L H ++ Sbjct: 667 FLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR-KHDAQF------- 718 Query: 190 TFIAIGXXXXXXXXXXXXTSPI--IHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EID 357 T I + S + +H + + N+L++S+ V DFGL +++ D E Sbjct: 719 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 778 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + +PE + + K T+ DV+S+GI+L E+ S G +P Sbjct: 779 YTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERP 824
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/165 (25%), Positives = 74/165 (44%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL L ++ Sbjct: 697 FLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQ---- 752 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFGL +++ D E + Sbjct: 753 ---LVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 809 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + F K T+ DV+S+GI++ E+ S G +P Sbjct: 810 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSYGERP 854
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 58.2 bits (139), Expect = 1e-08 Identities = 52/167 (31%), Positives = 77/167 (46%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSS----ECLL 174 F AE + ++RH NL+ L G + + +V +YM SL +L S +CLL Sbjct: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 175 DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 + A+ + +H + + NVL+ D A V DFGL K S Sbjct: 293 KFSLDVCEAM---------EYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQ 343 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 D K+ + + APE + K +T DV+SFGI+L E+ S GR P Sbjct: 344 DTGKLPVK----WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 58.2 bits (139), Expect = 1e-08 Identities = 48/165 (29%), Positives = 69/165 (41%), Gaps = 10/165 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV L + RH N+L G C P +V + SSL+ H+H + + ++ Sbjct: 470 FKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETK-----FKLN 523 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 T I IG + IIH +KS N+ L D +GDFGL + Sbjct: 524 TLIDIGRQVAQGMDYLHAKN-IIHRDLKSNNIFLHEDLSVKIGDFGLATA------KTRW 576 Query: 370 IGENQRG-------YHAPEYVM---FGKPTTGCDVYSFGIILLEL 474 GE Q + APE + + DVY+FGI++ EL Sbjct: 577 SGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYEL 621
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ +YM N SL A L D R Sbjct: 666 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-------DGRFT 718 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFG+ +++ D E + Sbjct: 719 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 778 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 779 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 823
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ +YM N SL A L D R Sbjct: 667 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-------DGRFT 719 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFG+ +++ D E + Sbjct: 720 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 780 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 824
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ +YM N SL A L D R Sbjct: 667 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-------DGRFT 719 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFG+ +++ D E + Sbjct: 720 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 780 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 824
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ +YM N SL A L D R Sbjct: 667 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-------DGRFT 719 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFG+ +++ D E + Sbjct: 720 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 780 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 824
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ +YM N SL A L D R Sbjct: 666 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-------DGRFT 718 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFG+ +++ D E + Sbjct: 719 VIQLVGILRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 778 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 779 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 823
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 57.8 bits (138), Expect = 2e-08 Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 18/179 (10%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRR- 186 F E E L ++H++++ G C +G I+V++YM + L L +LD + Sbjct: 540 FQREAELLTVLQHEHIVKFYGVCTEGDPLIMVFEYMKHGDLNRFLRSHGPDAKILDQGQG 599 Query: 187 --------------RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDF 324 T IA G +H + + N L+ D +GDF Sbjct: 600 QPCGQLTLSHMLQIATQIASGMVYLASLH-------FVHRDLATRNCLVGHDLVVKIGDF 652 Query: 325 GLMKLISDEIDHDKIIGENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 G+ + I D+ ++ G + PE +++ K TT D++SFG++L E+ T G++P Sbjct: 653 GMSRDIYST-DYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQP 710
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 57.8 bits (138), Expect = 2e-08 Identities = 46/167 (27%), Positives = 78/167 (46%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E +G+ H N++ L G + +++ +YM N +L L G S L+ Sbjct: 660 FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGM 719 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EI 354 R IA G +H + + N+L++S+ V DFGL +++ D E Sbjct: 720 LRG--IAAGMKYLANMNY-------VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEA 770 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 + G+ + APE + + K T+ DV+SFGI++ E +T G +P Sbjct: 771 TYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERP 817
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 57.8 bits (138), Expect = 2e-08 Identities = 52/167 (31%), Positives = 77/167 (46%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSS----ECLL 174 F AE + ++RH NL+ L G + + +V +YM SL +L S +CLL Sbjct: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 175 DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 + A+ + +H + + NVL+ D A V DFGL K S Sbjct: 293 KFSLDVLEAMEYLEG---------NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 D K+ + + APE + K +T DV+SFGI+L E+ S GR P Sbjct: 344 DTGKLPVK----WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 57.8 bits (138), Expect = 2e-08 Identities = 41/167 (24%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G ++V ++M N SL + L +L Sbjct: 683 FLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQ---- 738 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 +G + +H + + N+L++S+ V DFGL + + D+ + Sbjct: 739 ---LVGMLRGIAAGMRYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDASNPT 795 Query: 367 IIG----ENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G + + APE V + K T+ DV+S+GI++ E+ S G +P Sbjct: 796 YTGALGCKIPIRWTAPEAVQYRKFTSSSDVWSYGIVMWEVMSYGERP 842
>ANPRB_HUMAN (P20594) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 57.8 bits (138), Expect = 2e-08 Identities = 49/156 (31%), Positives = 69/156 (44%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V+ +L G C D P +V +Y P SL L + LDW R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSIN---LDWMFRYSL 623 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 S HGS+KS+N ++DS F + D+GL S D Sbjct: 624 INDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALY 681 Query: 379 NQRGYHAPEYVMFGK-PTTG---CDVYSFGIILLEL 474 ++ + APE + PTTG DVYSFGIIL E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEI 717
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 57.4 bits (137), Expect = 2e-08 Identities = 42/163 (25%), Positives = 72/163 (44%), Gaps = 5/163 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHG----THSSECLLDWRR 186 EV+ L RV+H N+++L G + L+ ++ SL LHG +S + W R Sbjct: 60 EVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWAR 119 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLL-DSDFQAHVGDFGLMKLISDEIDHD 363 + P+IH +K N+LL + + DFG + S + ++ Sbjct: 120 QC------AEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNN 173 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + + APE K T CD++S+ I+L E+ S ++P Sbjct: 174 R----GSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQP 212
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 57.4 bits (137), Expect = 2e-08 Identities = 40/165 (24%), Positives = 76/165 (46%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G + +++ +YM N +L L +L Sbjct: 661 FLSEASIMGQFSHHNIIPLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQ---- 716 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EIDH 360 +G + +H + + N+L++S+ V DFGL +++ D E + Sbjct: 717 ---LVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY 773 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 G+ + APE + + K T+ DV+S+GI++ E +T G +P Sbjct: 774 TTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERP 818
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 57.4 bits (137), Expect = 2e-08 Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH+ L+ L ++ P I V +Y+ SL L G + R Sbjct: 305 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYISKGSLLDFLKGEMGR-----YLRL 358 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H +++ N+L+ + V DFGL +LI D + Sbjct: 359 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 418 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L ELT+ GR P Sbjct: 419 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 460
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 57.0 bits (136), Expect = 3e-08 Identities = 41/171 (23%), Positives = 78/171 (45%), Gaps = 10/171 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C +G I+V++YM + L F HG + + + Sbjct: 581 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGP-DAVLMAEGN 639 Query: 184 RRTFIAIGXXXXXXXXXXX-----XTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD 348 R + + +H + + N L+ + +GDFG+ + + Sbjct: 640 RPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 699 Query: 349 EIDHDKIIGENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+S G++L E+ T G++P Sbjct: 700 T-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP 749
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 57.0 bits (136), Expect = 3e-08 Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL + L H ++ Sbjct: 668 FLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR-KHDAQF------- 719 Query: 190 TFIAIGXXXXXXXXXXXXTSPI--IHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EID 357 T I + S + +H + + N+L++S+ V DFGL +++ D E Sbjct: 720 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 779 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + +PE + K T+ DV+S+GI+L E+ S G +P Sbjct: 780 YTTRGGKIPVRWTSPEATAYRKFTSASDVWSYGIVLWEVMSYGERP 825
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 57.0 bits (136), Expect = 3e-08 Identities = 46/175 (26%), Positives = 75/175 (42%), Gaps = 11/175 (6%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDW 180 K F E +G+ H N++ L G ++V +YM N SL L T + W Sbjct: 759 KAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHW 818 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIH-----GSIKSTNVLLDSDFQAHVGDFGLMKLI- 342 + T + G +H + + NVLLD + + + DFGL + + Sbjct: 819 EKITEMLYGIASGMKYLTDMG---YVHRVSFLRDLAARNVLLDMELRCKIADFGLSRGVR 875 Query: 343 ----SDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 S E ++ G+ + APE + K T DV+SFG+++ E+ S G +P Sbjct: 876 SEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFGERP 930
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 57.0 bits (136), Expect = 3e-08 Identities = 52/167 (31%), Positives = 77/167 (46%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSS----ECLL 174 F AE + ++RH NL+ L G + + +V +YM SL +L S +CLL Sbjct: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 175 DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 + A+ + +H + + NVL+ D A V DFGL K S Sbjct: 293 KFSLDVCEAMEYLEG---------NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 D K+ + + APE + K +T DV+SFGI+L E+ S GR P Sbjct: 344 DTGKLPVK----WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 57.0 bits (136), Expect = 3e-08 Identities = 52/167 (31%), Positives = 77/167 (46%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERI-LVYDYMPNSSLFAHLHGTHSS----ECLL 174 F AE + ++RH NL+ L G + + +V +YM SL +L S +CLL Sbjct: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 175 DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 + A+ + +H + + NVL+ D A V DFGL K S Sbjct: 293 KFSLDVCEAMEYLEG---------NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 D K+ + + APE + K +T DV+SFGI+L E+ S GR P Sbjct: 344 DTGKLPVK----WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 57.0 bits (136), Expect = 3e-08 Identities = 46/168 (27%), Positives = 82/168 (48%), Gaps = 7/168 (4%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE++++ ++RHK++LSL G ++ + MP +L L + L+D Sbjct: 232 FQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVD 291 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI- 354 + + +A G + IH + + NVL+ + VGDFGL +L+ ++I Sbjct: 292 FASQ--VAEG-------MCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIY 342 Query: 355 -DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 H+ + + APE + G + DV+SFG++L E+ S G+ P Sbjct: 343 LSHEHNVPYK---WTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMP 387
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 56.6 bits (135), Expect = 4e-08 Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G ++V +YM N SL + L H ++ Sbjct: 667 FLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR-KHDAQF------- 718 Query: 190 TFIAIGXXXXXXXXXXXXTSPI--IHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EID 357 T I + S + +H + + N+L++S+ V DFGL +++ D E Sbjct: 719 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 778 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + +PE + + K T+ D +S+GI+L E+ S G +P Sbjct: 779 YTTRGGKIPIRWTSPEAIAYRKFTSASDAWSYGIVLWEVMSYGERP 824
>ANPRB_BOVIN (P46197) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 56.6 bits (135), Expect = 4e-08 Identities = 48/156 (30%), Positives = 69/156 (44%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V+ +L G C D P +V +Y P SL L + LDW R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSIN---LDWMFRYSL 623 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 + HGS+KS+N ++DS F + D+GL S D Sbjct: 624 INDLVKGMAFLHNSIIAS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALY 681 Query: 379 NQRGYHAPEYVMFGK-PTTG---CDVYSFGIILLEL 474 ++ + APE + PTTG DVYSFGIIL E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEI 717
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 56.6 bits (135), Expect = 4e-08 Identities = 44/174 (25%), Positives = 81/174 (46%), Gaps = 13/174 (7%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ +YM N SL A L D R Sbjct: 41 FLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKN-------DGRFT 93 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID--- 357 +G + +H + + N+L++S+ V DFG+ +++ ++ D Sbjct: 94 VIQLVGILRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAY 153 Query: 358 -HDKIIG--ENQRG-----YHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 +I G ++Q G + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 154 TTREITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMSYGERP 207
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 56.2 bits (134), Expect = 5e-08 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 11/172 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLL----- 174 F E E L ++H++++ G C +G I+V++YM + L L H + +L Sbjct: 584 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA-HGPDAVLMAEGN 642 Query: 175 ---DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLIS 345 + + + I + +H + + N L+ + +GDFG+ + + Sbjct: 643 PPTELTQSQMLHIAQQIAAGMVYLA-SQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY 701 Query: 346 DEIDHDKIIGENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+S G++L E+ T G++P Sbjct: 702 ST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP 752
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 56.2 bits (134), Expect = 5e-08 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 11/172 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLL----- 174 F E E L ++H++++ G C +G I+V++YM + L L H + +L Sbjct: 584 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA-HGPDAVLMAEGN 642 Query: 175 ---DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLIS 345 + + + I + +H + + N L+ + +GDFG+ + + Sbjct: 643 PPTELTQSQMLHIAQQIAAGMVYLA-SQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY 701 Query: 346 DEIDHDKIIGENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+S G++L E+ T G++P Sbjct: 702 ST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP 752
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 56.2 bits (134), Expect = 5e-08 Identities = 46/158 (29%), Positives = 79/158 (50%), Gaps = 6/158 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERIL--VYDYMPNSSLFAHL--HGTHSSECLLDWRR 186 E++ L + H++++ +G C D E+ L V +Y+P SL +L H ++ LL ++ Sbjct: 947 EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 1006 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 I G IH + + NVLLD+D +GDFGL K + + ++ + Sbjct: 1007 ---ICEGMAYLHAQHY-------IHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYR 1056 Query: 367 I--IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL 474 + G++ ++APE + K DV+SFG+ L EL Sbjct: 1057 VREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYEL 1094 Score = 33.1 bits (74), Expect = 0.42 Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 5/153 (3%) Frame = +1 Query: 31 LGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFIAIGX 210 + +V H +L + G C GPE I+V +Y+ + L L + W+ + Sbjct: 662 MSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLR-RERGHVPMAWK-----MVVA 715 Query: 211 XXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE---N 381 ++HG++ N+LL + G +KL + + E Sbjct: 716 QQLASALSYLENKNLVHGNVCGRNILL-ARLGLAEGTSPFIKLSDPGVGLGALSREERVE 774 Query: 382 QRGYHAPEYVMFG--KPTTGCDVYSFGIILLEL 474 + + APE + G +T D + FG LLE+ Sbjct: 775 RIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 807
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 56.2 bits (134), Expect = 5e-08 Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G ++V ++M N +L + L L D R Sbjct: 233 FLSEASIMGQFDHPNVIHLEGVLTRSCPVLIVTEFMENGALDSFLR-------LNDGRFT 285 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + NVL++S+ V DFGL + + D Sbjct: 286 VTQLVGMLRGIAAGMKYLSDMNYVHRDLAARNVLVNSNLVCKVSDFGLSRFLDDNSSDPT 345 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + F K T+ DV+S+GI++ E+ S G +P Sbjct: 346 YTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERP 392
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 56.2 bits (134), Expect = 5e-08 Identities = 44/167 (26%), Positives = 70/167 (41%), Gaps = 9/167 (5%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH-SSECLLDWRRRTF 195 E + H N+++L+ C + P LV +Y L L G L++W Sbjct: 164 EARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNW----- 218 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLL----DSDFQAH----VGDFGLMKLISDE 351 A+ P+IH +KS N+LL +SD H + DFGL + + Sbjct: 219 -AVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EW 274 Query: 352 IDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 ++ + APE + + G DV+SFG++L EL +G P Sbjct: 275 HKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVP 321
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 56.2 bits (134), Expect = 5e-08 Identities = 42/156 (26%), Positives = 79/156 (50%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCA-DGPERI-LVYDYMPNSSLFAHLHGTHSSECLLDWRRRT 192 E+E L + H+N++ +G C DG I L+ +++P+ SL +L + ++ +++ Sbjct: 924 EIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNK---INLKQQL 980 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 AI + +H + + NVL++S+ Q +GDFGL K I + ++ + Sbjct: 981 KYAI---QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVK 1037 Query: 373 GENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL 474 + ++APE ++ K DV+SFG+ L EL Sbjct: 1038 DDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHEL 1073 Score = 32.0 bits (71), Expect = 0.93 Identities = 35/160 (21%), Positives = 64/160 (40%), Gaps = 5/160 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F + +V HK+++ L G C E I+V +++ L +H S W+ + Sbjct: 634 FFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH-RKSDALTTPWKFK 692 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSD-FQAHVGDFGLMKLISDEIDHDK 366 ++HG++ + N+LL + + +G F +KL I Sbjct: 693 V-----AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPF--IKLSDPGIPVSV 745 Query: 367 IIGE---NQRGYHAPEYVMFGKP-TTGCDVYSFGIILLEL 474 + + + + APE V K + D +SFG L E+ Sbjct: 746 LTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI 785
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 56.2 bits (134), Expect = 5e-08 Identities = 47/158 (29%), Positives = 79/158 (50%), Gaps = 6/158 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERI--LVYDYMPNSSLFAHL--HGTHSSECLLDWRR 186 E+E L + H++++ +G C D E+ LV +Y+P SL +L H ++ LL ++ Sbjct: 940 EIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQ 999 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 I G IH + + NVLLD+D +GDFGL K + + ++ + Sbjct: 1000 ---ICEGMAYLHAQHY-------IHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYR 1049 Query: 367 I--IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL 474 + G++ ++APE + K DV+SFG+ L EL Sbjct: 1050 VREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYEL 1087
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 56.2 bits (134), Expect = 5e-08 Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F E + + R+RH L+ L ++ P I V ++M SL L L+D Sbjct: 309 FLEEAQIMKRLRHDKLVQLYAVVSEEPIYI-VTEFMSQGSLLDFLKDGDGRYLKLPQLVD 367 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + IA G IH +++ N+L+ + + DFGL +LI D Sbjct: 368 MAAQ--IAAGMAYIERMNY-------IHRDLRAANILVGDNLVCKIADFGLARLIEDNEY 418 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE +FGK T DV+SFGI+L EL T GR P Sbjct: 419 TARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTELVTKGRVP 464
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 56.2 bits (134), Expect = 5e-08 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 11/172 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLL----- 174 F E E L ++H++++ G C +G I+V++YM + L L H + +L Sbjct: 585 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA-HGPDAVLMAEGN 643 Query: 175 ---DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLIS 345 + + + I + +H + + N L+ + +GDFG+ + + Sbjct: 644 PPTELTQSQMLHIAQQIAAGMVYLA-SQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY 702 Query: 346 DEIDHDKIIGENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +M+ K TT DV+S G++L E+ T G++P Sbjct: 703 ST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP 753
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 56.2 bits (134), Expect = 5e-08 Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 2/163 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL-HGTHSSECLLDWRR 186 F E + + ++ H NLL L C G +V + M S+ +L HG + L Sbjct: 106 FVQEAQVMKKIHHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITL----- 160 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 + + S IH + + N+L+ V DFGL ++I ++I + + Sbjct: 161 HQMVDMSAQIASGMTYLEAHS-YIHRDLAARNILVGEGNVCKVADFGLARVIKEDIYNPR 219 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++ + T DV+SFG+++ E+ T GR P Sbjct: 220 EGTKFPIKWTAPEAALYNRFTIKSDVWSFGVLISEIVTHGRMP 262
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 55.8 bits (133), Expect = 6e-08 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 2/162 (1%) Frame = +1 Query: 13 AAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRT 192 A E+++L +RH+ L+ L C+ G +V + M +L A L GT L R Sbjct: 271 AKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFL-GTPEGRAL-----RL 324 Query: 193 FIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 +G ++H + + NVL+D V DFGL +L+ D+I Sbjct: 325 PPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSS 384 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + DV+SFG++L E+ T G+ P Sbjct: 385 SSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCP 426
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 55.8 bits (133), Expect = 6e-08 Identities = 47/166 (28%), Positives = 76/166 (45%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSS---ECLLDW 180 F AE + + ++RH L+ L C G ++ + M SL +L G + L+D Sbjct: 135 FLAEAQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQGEAGALKLPQLIDM 194 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 + +A G IH + + N+L+ + V DFGL +LI + D+ Sbjct: 195 AAQ--VAAGMAYLELHNY-------IHRDLAARNILVGDNNICKVADFGLARLIVSD-DY 244 Query: 361 DKIIGEN-QRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + G + APE +F + + DV+SFGI++ EL T GR P Sbjct: 245 NATEGAKFPIKWTAPEAALFNRFSIKSDVWSFGILITELVTYGRIP 290
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 55.8 bits (133), Expect = 6e-08 Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH L+ L ++ P I V +YM SL L L Sbjct: 310 FLEEAQIMKKLRHDKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKDGEGRALKLP---- 364 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + + + IH ++S N+L+ + + DFGL +LI D + Sbjct: 365 NLVDMAAQVAAGMAYIERMN-YIHRDLRSANILVGDNLVCKIADFGLARLIEDNEYTARQ 423 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++G+ T DV+SFGI+L EL T GR P Sbjct: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 55.8 bits (133), Expect = 6e-08 Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + R+RH L+ L C +V + M SL +L G + +L + Sbjct: 280 FLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRG---EDGVLKIEQL 336 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 +A IH + + N+L+ V DFGL ++I +EI Sbjct: 337 VDVA---AQVASGMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVIDEEIYEAHT 393 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLE-LTSGRKP 492 + + APE M+ + T DV+SFG++L E +T GR P Sbjct: 394 GAKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYGRFP 435
>ANPRB_RAT (P16067) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 55.5 bits (132), Expect = 8e-08 Identities = 48/156 (30%), Positives = 68/156 (43%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V+ +L G C D P +V +Y P SL L + LDW R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSIN---LDWMFRYSL 623 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 S HGS+KS+N ++DS F + D+GL S D Sbjct: 624 INDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALY 681 Query: 379 NQRGYHAPEYVMFGK-PTTG---CDVYSFGIILLEL 474 ++ + APE + PTTG DVYSF IIL E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEI 717
>ANPRB_MOUSE (Q6VVW5) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 55.5 bits (132), Expect = 8e-08 Identities = 48/156 (30%), Positives = 68/156 (43%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V+ +L G C D P +V +Y P SL L + LDW R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSIN---LDWMFRYSL 623 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 S HGS+KS+N ++DS F + D+GL S D Sbjct: 624 INDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALY 681 Query: 379 NQRGYHAPEYVMFGK-PTTG---CDVYSFGIILLEL 474 ++ + APE + PTTG DVYSF IIL E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEI 717
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 55.5 bits (132), Expect = 8e-08 Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 3/158 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPER--ILVYDYMPNSSLFAHLHGTHSSECLLDWR 183 F E + + ++RH+ ++ L G C + + +++ +YM N SL +L + L+ Sbjct: 260 FVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQM 319 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI-DH 360 I + ++H +++ N+L+ +D V DFGL +L + D Sbjct: 320 VHMMAEISEGMAYLE-----SEKVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQ 374 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL 474 +K + APE T+ DV+S+GI++ E+ Sbjct: 375 EKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEI 412
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 55.5 bits (132), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 2/157 (1%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTF 195 +E++++ ++RHK++L+L + G ++ + M SL L S E +L Sbjct: 234 SEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRD--SDEKVLPVSELLD 291 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI--DHDKI 369 IA + IH + + N+L+ + VGDFGL +LI +++ HD Sbjct: 292 IA---WQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHN 348 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS 480 I + APE + G +T DV+SFGI+L E+ S Sbjct: 349 IPYK---WTAPEALSRGHYSTKSDVWSFGILLHEMFS 382
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 55.1 bits (131), Expect = 1e-07 Identities = 43/162 (26%), Positives = 71/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE + + ++RH L+ L C ++ + M + SL +L L + + Sbjct: 288 FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSL--KMQ 345 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 T I + + IH + + NVL+ + DFGL +LI ++ ++ Sbjct: 346 TLIDMAAQIAAGMAYLESQN-YIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARV 404 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + APE + K + DV+SFGI+L EL T GR P Sbjct: 405 GARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIP 446
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/167 (22%), Positives = 74/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N SL + L ++ Sbjct: 685 FLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQ---- 740 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G +H + + N+L++S+ V DFGL + + D+ Sbjct: 741 ---LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 797 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 798 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 844
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/158 (24%), Positives = 68/158 (43%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E E L + H+N++ G + P +V +Y SL+ +++ S E +D Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEE--MDMEHIMTW 110 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A +IH +KS NV++ +D + DFG + + H ++G Sbjct: 111 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-HNHTTHMSLVGT 169 Query: 379 NQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + APE + + CD YS+G++L E+ + P Sbjct: 170 FP--WMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVP 205
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 55.1 bits (131), Expect = 1e-07 Identities = 40/167 (23%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G + +++ ++M N +L + L L D + Sbjct: 661 FLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLR-------LNDGQFT 713 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLI----SDEI 354 +G +H + + N+L++S+ V DFGL + + SD Sbjct: 714 VIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPT 773 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + F K T+ D +S+GI++ E+ S G +P Sbjct: 774 YTSSLGGKISIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERP 820
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 55.1 bits (131), Expect = 1e-07 Identities = 49/161 (30%), Positives = 77/161 (47%), Gaps = 6/161 (3%) Frame = +1 Query: 28 SLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDWRRRTFI 198 ++G + H +++ L G C G LV Y+P SL H+ G + LL+W + I Sbjct: 762 AIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQ--I 818 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A G ++H ++ + NVLL S Q V DFG+ L+ + D + E Sbjct: 819 AKGMYYLEEHG-------MVHRNLAARNVLLKSPSQVQVADFGVADLLPPD-DKQLLYSE 870 Query: 379 NQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + A E + FGK T DV+S+G+ + EL T G +P Sbjct: 871 AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEP 911
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 55.1 bits (131), Expect = 1e-07 Identities = 49/161 (30%), Positives = 77/161 (47%), Gaps = 6/161 (3%) Frame = +1 Query: 28 SLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDWRRRTFI 198 ++G + H +++ L G C G LV Y+P SL H+ G + LL+W + I Sbjct: 762 AIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQ--I 818 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A G ++H ++ + NVLL S Q V DFG+ L+ + D + E Sbjct: 819 AKGMYYLEEHG-------MVHRNLAARNVLLKSPSQVQVADFGVADLLPPD-DKQLLYSE 870 Query: 379 NQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + A E + FGK T DV+S+G+ + EL T G +P Sbjct: 871 AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEP 911
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/167 (22%), Positives = 74/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N SL + L ++ Sbjct: 675 FLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQ---- 730 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G +H + + N+L++S+ V DFGL + + D+ Sbjct: 731 ---LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 787 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 788 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 834
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/167 (22%), Positives = 74/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N SL + L ++ Sbjct: 667 FLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQ---- 722 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G +H + + N+L++S+ V DFGL + + D+ Sbjct: 723 ---LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 779 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 780 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 826
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/167 (23%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G + +++ ++M N +L + L L D + Sbjct: 661 FLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLR-------LNDGQFT 713 Query: 190 TFIAIGXXXXXXXXXXXXTS-PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLI----SDEI 354 +G +H + + N+L++S+ V DFGL + + SD Sbjct: 714 VIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPT 773 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + F K T+ D +S+GI++ E+ S G +P Sbjct: 774 YTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERP 820
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 54.7 bits (130), Expect = 1e-07 Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 9/167 (5%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH-SSECLLDWRRRTF 195 E + ++H N+++LRG C P LV ++ L L G + L++W Sbjct: 191 EAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNW----- 245 Query: 196 IAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQ--------AHVGDFGLMKLISDE 351 A+ PIIH +KS+N+L+ + + DFGL + + Sbjct: 246 -AVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EW 301 Query: 352 IDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 K+ + APE + + G DV+S+G++L EL +G P Sbjct: 302 HRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVP 348
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 54.3 bits (129), Expect = 2e-07 Identities = 51/170 (30%), Positives = 71/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC---LLDW 180 F EV L + RH N+L GY +V + SSL+ HLH + L+D Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDI 448 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + S Sbjct: 449 ARQT---------AQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGS 499 Query: 361 DKIIGENQRG---YHAPEYVMF--GKP-TTGCDVYSFGIILLELTSGRKP 492 ++ E G + APE + P + DVYS+GI+L EL +G P Sbjct: 500 QQV--EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP 547
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 54.3 bits (129), Expect = 2e-07 Identities = 50/170 (29%), Positives = 70/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC---LLDW 180 F EV L + RH N+L GY +V + SSL+ HLH + L+D Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDI 448 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + S Sbjct: 449 ARQT---------AQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGS 499 Query: 361 DKIIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 ++ E G + APE + + DVYS+GI+L EL +G P Sbjct: 500 QQV--EQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELP 547
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 54.3 bits (129), Expect = 2e-07 Identities = 51/170 (30%), Positives = 71/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC---LLDW 180 F EV L + RH N+L GY +V + SSL+ HLH + L+D Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDI 448 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + S Sbjct: 449 ARQT---------AQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGS 499 Query: 361 DKIIGENQRG---YHAPEYVMF--GKP-TTGCDVYSFGIILLELTSGRKP 492 ++ E G + APE + P + DVYS+GI+L EL +G P Sbjct: 500 QQV--EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP 547
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 54.3 bits (129), Expect = 2e-07 Identities = 50/170 (29%), Positives = 70/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC---LLDW 180 F EV L + RH N+L GY +V + SSL+ HLH + L+D Sbjct: 123 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDI 181 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + S Sbjct: 182 ARQT---------AQGMDYLHAKNIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGS 232 Query: 361 DKIIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 ++ E G + APE + + DVYS+GI+L EL +G P Sbjct: 233 QQV--EQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELP 280
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 54.3 bits (129), Expect = 2e-07 Identities = 50/170 (29%), Positives = 70/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC---LLDW 180 F EV L + RH N+L GY +V + SSL+ HLH + L+D Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDI 448 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + S Sbjct: 449 ARQT---------AQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGS 499 Query: 361 DKIIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 ++ E G + APE + + DVYS+GI+L EL +G P Sbjct: 500 QQV--EQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELP 547
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 54.3 bits (129), Expect = 2e-07 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + +RH L+ L ++ P I V ++M + SL L D R Sbjct: 303 FLEEAQVMKLLRHDKLVQLYAVVSEEPIYI-VTEFMCHGSLLDFLKNPEGQ----DLRLP 357 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + + + IH +++ N+L+ + DFGL +LI D+ + Sbjct: 358 QLVDMAAQVAEGMAYMERMN-YIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQ 416 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE +FG+ T DV+SFGI+L EL T GR P Sbjct: 417 GSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIP 458
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 54.3 bits (129), Expect = 2e-07 Identities = 46/166 (27%), Positives = 74/166 (44%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + ++H L+ L P I+ ++M SL L S+ L+D Sbjct: 279 FLAEANLMKTLQHDKLVKLHAVVTKEPIYIIT-EFMAKGSLLDFLKSDEGSKQPLPKLID 337 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + + IA G IH +++ N+L+ + + DFGL ++I D Sbjct: 338 FSAQ--IAEGMAFIEQRNY-------IHRDLRAANILVSASLVCKIADFGLARIIEDNEY 388 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + FG T DV+SFGI+L+E+ T GR P Sbjct: 389 TAREGAKFPIKWTAPEAINFGSSTIKSDVWSFGILLMEIVTYGRIP 434
>ANPRB_ANGJA (P55202) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1050 Score = 54.3 bits (129), Expect = 2e-07 Identities = 46/162 (28%), Positives = 71/162 (43%), Gaps = 4/162 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V+ +L G C D P +V +Y P SL L + LDW R + Sbjct: 571 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESIN---LDWMFRYSL 627 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 HG++KS+N ++DS F + D+GL S + D Sbjct: 628 INDIVKGMNFLHNSYIGS--HGNLKSSNCVVDSRFVLKITDYGLASFRSSCENEDSHALY 685 Query: 379 NQRGYHAPEYVMFGK-PTTGC---DVYSFGIILLELTSGRKP 492 ++ + APE +++ + P G DVYSFGIIL E+ P Sbjct: 686 AKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGP 727
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 54.3 bits (129), Expect = 2e-07 Identities = 50/168 (29%), Positives = 72/168 (42%), Gaps = 7/168 (4%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV L + RH N+L GY +V + SSL+ HLH +LD + + Sbjct: 381 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYYHLH-------VLDTKFQ 432 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 F I + IIH +KS N+ L +GDFGL + + + Sbjct: 433 MFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQ 492 Query: 367 IIGENQRG---YHAPEYVMF--GKP-TTGCDVYSFGIILLELTSGRKP 492 + E G + APE + P + DVYS+GI+L EL +G P Sbjct: 493 V--EQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP 538
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 54.3 bits (129), Expect = 2e-07 Identities = 43/170 (25%), Positives = 75/170 (44%), Gaps = 7/170 (4%) Frame = +1 Query: 4 WXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWR 183 W F E +G+ H ++L L G +++ ++M N +L A L Sbjct: 669 WNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLK-----------E 717 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-----IHGSIKSTNVLLDSDFQAHVGDFGLMKLISD 348 R +A G + + +H + + N+L++ + V DFGL +L+ D Sbjct: 718 REDQLAPGQLVAMLLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDD 777 Query: 349 -EIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + ++ G+ + APE + TT DV+SFGI++ E+ S G KP Sbjct: 778 FDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKP 827
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/162 (25%), Positives = 72/162 (44%), Gaps = 4/162 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLD----WRR 186 E E L + H+N++ G + P +V +Y SL+ +++ S E +D W Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWA- 111 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 T +A G +IH +KS NV++ +D + DFG + + H Sbjct: 112 -TDVAKGMHYLHMEAPVK----VIHRDLKSRNVVIAADGVLKICDFGASRF-HNHTTHMS 165 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 ++G + APE + + CD YS+G++L E+ + P Sbjct: 166 LVGTFP--WMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVP 205
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 54.3 bits (129), Expect = 2e-07 Identities = 50/170 (29%), Positives = 70/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC---LLDW 180 F EV L + RH N+L GY +V + SSL+ HLH + L+D Sbjct: 65 FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDI 123 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + S Sbjct: 124 ARQT---------AQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGS 174 Query: 361 DKIIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 ++ E G + APE + + DVYS+GI+L EL +G P Sbjct: 175 QQV--EQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELP 222
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 54.3 bits (129), Expect = 2e-07 Identities = 46/167 (27%), Positives = 77/167 (46%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F +E +G+ H N++ L G ++V +YM N SL L G + LL Sbjct: 672 FLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFTVIQLLGM 731 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISD--EI 354 R IA G +H + + N+L++ + V DFGL +++ D E Sbjct: 732 LRG--IAAGMQYLSEMNY-------VHRDLAARNILVNRNLVCKVSDFGLSRVLEDDPEA 782 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 783 AYTTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGERP 829
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 53.9 bits (128), Expect = 2e-07 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + +++H L+ L ++ P I V +YM SL L L Sbjct: 307 FLEEAQIMKKLKHDKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKDGEGRALKLP---- 361 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + + + IH ++S N+L+ + + DFGL +LI D + Sbjct: 362 NLVDMAAQVAAGMAYIERMN-YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ 420 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++G+ T DV+SFGI+L EL T GR P Sbjct: 421 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 462
>ERK1_CANAL (P28869) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) (MAPK 1) Length = 417 Score = 53.9 bits (128), Expect = 2e-07 Identities = 45/164 (27%), Positives = 79/164 (48%), Gaps = 8/164 (4%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYD-----YMPNSSLFAHLHGTHSSECLLDWR 183 E++ L H+N++S+ +R + Y+ Y+ + LH ++ L D Sbjct: 114 ELKLLKHFNHENIISILAI-----QRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDH 168 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 + FI ++ ++H +K +N+LL+S+ + DFGL + I+ + D+ Sbjct: 169 IQYFI----YQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNY 224 Query: 364 KIIGE--NQRGYHAPEYVM-FGKPTTGCDVYSFGIILLELTSGR 486 + E R Y APE ++ F + TT DV+S G IL E+ SGR Sbjct: 225 GFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGR 268
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/167 (22%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L ++ Sbjct: 665 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ---- 720 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + N+L++S+ V DFGL + + D+ Sbjct: 721 ---LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 777 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 778 YTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERP 824
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 53.9 bits (128), Expect = 2e-07 Identities = 38/167 (22%), Positives = 73/167 (43%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N SL + L ++ Sbjct: 668 FLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQ---- 723 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G +H + + N L++S+ V DFGL + + D+ Sbjct: 724 ---LVGMLRGIAAGMKYLADMNYVHRDLAARNTLVNSNLVCKVSDFGLSRFLEDDTSDPT 780 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 781 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERP 827
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/173 (24%), Positives = 78/173 (45%), Gaps = 12/173 (6%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C +G ++V++YM + L F HG ++ L Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-DAKLLAGGE 615 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 +G + +H + + N L+ +GDFG+ + I Sbjct: 616 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 675 Query: 343 SDEIDHDKIIGENQRG--YHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 D+ ++ G + PE +++ K TT DV+SFG++L E+ T G++P Sbjct: 676 YST-DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP 727
>KBN8_YEAST (P38070) Probable serine/threonine-protein kinase YBR028C (EC| 2.7.11.1) Length = 525 Score = 53.9 bits (128), Expect = 2e-07 Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 11/170 (6%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL--HGTHSSECLLDWRRR 189 AE L + H N++ L D + L+ Y+P LF HL HGT LD Sbjct: 201 AERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGT------LD---E 251 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 T ++ T +++ +K N LL+ + DFGL K +++ D+ Sbjct: 252 TTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAVDEE 311 Query: 370 IGENQRGYHA----PEY----VMFGKP-TTGCDVYSFGIILLELTSGRKP 492 EN ++ PEY ++ GK + CD YS G +L ++ G+ P Sbjct: 312 DPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPP 361
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/167 (22%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L ++ Sbjct: 583 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ---- 638 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + N+L++S+ V DFGL + + D+ Sbjct: 639 ---LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 695 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 696 YTSSLGGKIPVRWTAPEAIRYRKFTSASDVWSYGIVMWEVMSYGERP 742
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 53.5 bits (127), Expect = 3e-07 Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 14/172 (8%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E + + R+RH ++ L G + + LV +YM +L L S+ + R I Sbjct: 63 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEI 122 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGL------MKLISDEIDH 360 G +IH +K N+L+D+DF + D GL KL ++E + Sbjct: 123 IEGMCYLHGKG-------VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNE 175 Query: 361 DKIIGENQRG------YHAPEYV--MFGKPTTGCDVYSFGIILLELTSGRKP 492 + + + Y APE++ + KPT DVYSF ++L + + ++P Sbjct: 176 LREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEP 227
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 53.5 bits (127), Expect = 3e-07 Identities = 37/167 (22%), Positives = 74/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L ++ Sbjct: 665 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ---- 720 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G +H + + N+L++S+ V DFGL + + D+ Sbjct: 721 ---LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 777 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 778 YTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERP 824
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 53.5 bits (127), Expect = 3e-07 Identities = 37/167 (22%), Positives = 74/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L ++ Sbjct: 665 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ---- 720 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G +H + + N+L++S+ V DFGL + + D+ Sbjct: 721 ---LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 777 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 778 YTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERP 824
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 53.5 bits (127), Expect = 3e-07 Identities = 40/159 (25%), Positives = 69/159 (43%), Gaps = 1/159 (0%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E+E+L +RH+ L+ L C+ G +V + M +L +L + L Sbjct: 277 EIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFAC 336 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 + ++H + + NVL+ D V DFGL +L+ D++ + Sbjct: 337 QVAEGMSYLEERR-----VVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSK 391 Query: 379 NQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + APE + + DV+SFGI+L E+ T G+ P Sbjct: 392 IPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCP 430
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 53.5 bits (127), Expect = 3e-07 Identities = 39/167 (23%), Positives = 76/167 (45%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L L D + Sbjct: 674 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR-------LNDGQFT 726 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + N+L++S+ V DFGL + + D+ Sbjct: 727 VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPT 786 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 787 YTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 833
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 53.5 bits (127), Expect = 3e-07 Identities = 39/167 (23%), Positives = 76/167 (45%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L L D + Sbjct: 679 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR-------LNDGQFT 731 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + N+L++S+ V DFGL + + D+ Sbjct: 732 VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPT 791 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 792 YTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 838
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 53.5 bits (127), Expect = 3e-07 Identities = 39/167 (23%), Positives = 76/167 (45%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L L D + Sbjct: 669 FLSEASIMGQFDHPNIIHLEGVVTKSRPVMIITEFMENCALDSFLR-------LNDGQFT 721 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + N+L++S+ V DFGL + + D+ Sbjct: 722 VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPADPT 781 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 782 YTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 828
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 53.5 bits (127), Expect = 3e-07 Identities = 45/166 (27%), Positives = 72/166 (43%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + +++HK L+ L + P I+ +YM N SL L + LLD Sbjct: 284 FLAEANLMKQLQHKRLVRLYAVVTEEPIYIIT-EYMENGSLVDFLKTPSGIKLTINKLLD 342 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + + IH +++ N+L+ + DFGL +LI D Sbjct: 343 MAAQIVEGMAFLEERNY---------IHRDLRAANILVSDTLSCKIADFGLARLIEDNEY 393 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + +G T DV+SFGI++ E+ T GR P Sbjct: 394 TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILMTEIVTHGRIP 439
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 53.5 bits (127), Expect = 3e-07 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + +++H L+ L ++ P I V +YM SL L L Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKDGEGRALKLP---- 364 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + + + IH ++S N+L+ + + DFGL +LI D + Sbjct: 365 NLVDMAAQVARGMAYIERMN-YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ 423 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++G+ T DV+SFGI+L EL T GR P Sbjct: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 53.5 bits (127), Expect = 3e-07 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + +++H L+ L ++ P I V +YM SL L L Sbjct: 310 FLEEAQIMKKLKHDKLVQLYAVVSEEPIYI-VTEYMNKGSLLDFLKDGEGRALKLP---- 364 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + + + IH ++S N+L+ + + DFGL +LI D + Sbjct: 365 NLVDMAAQVAAGMAYIERMN-YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ 423 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++G+ T DV+SFGI+L EL T GR P Sbjct: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 53.1 bits (126), Expect = 4e-07 Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++H NL+ L G C P +V +YMP +L +L EC + Sbjct: 329 FLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-----ECNREEVTA 383 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH + + N L+ + V DFGL +L++ + Sbjct: 384 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 443 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + + DV++FG++L E+ T G P Sbjct: 444 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSP 485
>DAF4_CAEEL (P50488) Cell-surface receptor daf-4 precursor (EC 2.7.11.30)| (Abnormal dauer formation protein 4) Length = 744 Score = 53.1 bits (126), Expect = 4e-07 Identities = 30/86 (34%), Positives = 47/86 (54%), Gaps = 6/86 (6%) Frame = +1 Query: 250 PIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE-NQRGYHAPEYVMFGKP 426 PIIH IKS N+L+ SD + DFGL ++ S +I+ ++G+ + Y +PE + Sbjct: 435 PIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLGQVGTKRYMSPEMLEGATE 494 Query: 427 TT-----GCDVYSFGIILLELTSGRK 489 T DVYS G+++ E+ S K Sbjct: 495 FTPTAFKAMDVYSMGLVMWEVISRTK 520
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 53.1 bits (126), Expect = 4e-07 Identities = 41/165 (24%), Positives = 74/165 (44%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL--HGTHSSEC-LLDW 180 F E +++ ++ H L+ G C+ +V +Y+ N L +L HG C LL+ Sbjct: 433 FFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEM 492 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 + IH + + N L+DSD V DFG+ + + D+ Sbjct: 493 ---------CYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYV 543 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + + APE + K ++ DV++FGI++ E+ S G++P Sbjct: 544 SSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQP 588
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 53.1 bits (126), Expect = 4e-07 Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + +++H+ L+ L P I+ +YM N SL L + LLD Sbjct: 284 FLAEANLMKQLQHQRLVRLYAVVTQEPIYIIT-EYMENGSLVDFLKTPSGIKLTINKLLD 342 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + IA G IH +++ N+L+ + DFGL +LI D Sbjct: 343 MAAQ--IAEGMAFIEERNY-------IHRDLRAANILVSDTLSCKIADFGLARLIEDNEY 393 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + +G T DV+SFGI+L E+ T GR P Sbjct: 394 TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP 439
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 53.1 bits (126), Expect = 4e-07 Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + +++H+ L+ L P I+ +YM N SL L + LLD Sbjct: 284 FLAEANLMKQLQHQRLVRLYAVVTQEPIYIIT-EYMENGSLVDFLKTPSGIKLTINKLLD 342 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + IA G IH +++ N+L+ + DFGL +LI D Sbjct: 343 MAAQ--IAEGMAFIEERNY-------IHRDLRAANILVSDTLSCKIADFGLARLIEDNEY 393 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + +G T DV+SFGI+L E+ T GR P Sbjct: 394 TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP 439
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 52.8 bits (125), Expect = 5e-07 Identities = 44/162 (27%), Positives = 70/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + +++H L+ L + P I V +YM SL L L Sbjct: 307 FLEEAQIMKKLKHDKLVQLYAVVSRRPIYI-VTEYMSKGSLLIFLKDGEGRALKLP---- 361 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + + + IH ++S N+L+ + + DFGL +LI D + Sbjct: 362 NLVDMAAQVAAGMAYIERMN-YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ 420 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE ++G+ T DV+SFGI+L EL T GR P Sbjct: 421 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 462
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 52.8 bits (125), Expect = 5e-07 Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + +RH L+ L ++ P I V ++M SL L +L Sbjct: 291 FLEEAQIMKLLRHDKLVQLYAVVSEEPIYI-VTEFMCYGSLLDFLKDREGQNLMLP---- 345 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH +++ N+L+ + DFGL +LI D + + Sbjct: 346 -HLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQ 404 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE +FG+ T DV+SFGI+L EL T GR P Sbjct: 405 GTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVP 446
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/164 (25%), Positives = 72/164 (43%), Gaps = 3/164 (1%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH--GTHSSECLLDWR 183 F E + ++H NL+ L G C P ++ ++M + +L L G + + + Sbjct: 412 FLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLY 471 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHD 363 T IA G IH + + N L+ + V DFGL +L+ D+ Sbjct: 472 MATQIASGMSYLESRNY-------IHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTA 524 Query: 364 KIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + K +T DV++FG++L E+ T G P Sbjct: 525 HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSP 568
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/170 (24%), Positives = 74/170 (43%), Gaps = 7/170 (4%) Frame = +1 Query: 4 WXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWR 183 W F E +G+ H ++L L G +++ ++M N +L A L Sbjct: 668 WNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLR-----------E 716 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-----IHGSIKSTNVLLDSDFQAHVGDFGLMKLISD 348 R + G + + +H + + N+L++ + V DFGL +L+ D Sbjct: 717 REDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDD 776 Query: 349 -EIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + ++ G+ + APE + TT DV+SFGI++ E+ S G KP Sbjct: 777 FDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKP 826
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 52.8 bits (125), Expect = 5e-07 Identities = 45/166 (27%), Positives = 75/166 (45%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + ++H L+ L + P +V ++M SL L S+ L+D Sbjct: 299 FLAEANLMKSLQHDKLVKLHAVVSQEPI-FIVTEFMAKGSLLDFLKSEEGSKQPLPKLID 357 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + + I+ G IH +++ N+L+ + + DFGL ++I D Sbjct: 358 FSAQ--ISEGMAFIEQRNY-------IHRDLRAANILVSASLVCKIADFGLARIIEDNEY 408 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + FG T DV+SFGI+L+E+ T GR P Sbjct: 409 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP 454
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 52.8 bits (125), Expect = 5e-07 Identities = 46/166 (27%), Positives = 74/166 (44%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + ++H L+ L P I+ ++M SL L S+ L+D Sbjct: 301 FLAEANVMKTLQHDKLVKLHAVVTKEPIYIIT-EFMAKGSLLDFLKSDEGSKQPLPKLID 359 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + + IA G IH +++ N+L+ + + DFGL ++I D Sbjct: 360 FSAQ--IAEGMAFIEQRNY-------IHRDLRAANILVSASLVCKIADFGLARVIEDNEY 410 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + FG T DV+SFGI+L+E+ T GR P Sbjct: 411 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP 456
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 52.8 bits (125), Expect = 5e-07 Identities = 45/167 (26%), Positives = 70/167 (41%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGT-----HSSECLL 174 F E+ L RV H N++ L G C + LV +Y SL+ LHG +++ + Sbjct: 74 FIVELRQLSRVNHPNIVKLYGACLNPV--CLVMEYAEGGSLYNVLHGAEPLPYYTAAHAM 131 Query: 175 DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQA-HVGDFGLMKLISDE 351 W + +IH +K N+LL + + DFG I Sbjct: 132 SW------CLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH 185 Query: 352 IDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + ++K + APE + CDV+S+GIIL E+ + RKP Sbjct: 186 MTNNK----GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKP 228
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 52.8 bits (125), Expect = 5e-07 Identities = 45/167 (26%), Positives = 70/167 (41%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGT-----HSSECLL 174 F E+ L RV H N++ L G C + LV +Y SL+ LHG +++ + Sbjct: 74 FIVELRQLSRVNHPNIVKLYGACLNPV--CLVMEYAEGGSLYNVLHGAEPLPYYTAAHAM 131 Query: 175 DWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQA-HVGDFGLMKLISDE 351 W + +IH +K N+LL + + DFG I Sbjct: 132 SW------CLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH 185 Query: 352 IDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + ++K + APE + CDV+S+GIIL E+ + RKP Sbjct: 186 MTNNK----GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKP 228
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 52.8 bits (125), Expect = 5e-07 Identities = 45/166 (27%), Positives = 75/166 (45%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + ++H L+ L + P +V ++M SL L S+ L+D Sbjct: 278 FLAEANLMKTLQHDKLVKLHAVVSQEPI-FIVTEFMAKGSLLDFLKSEEGSKQPLPKLID 336 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + + I+ G IH +++ N+L+ + + DFGL ++I D Sbjct: 337 FSAQ--ISEGMAFIEQRNY-------IHRDLRAANILVSASLVCKIADFGLARIIEDNEY 387 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + FG T DV+SFGI+L+E+ T GR P Sbjct: 388 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP 433
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 52.4 bits (124), Expect = 7e-07 Identities = 30/80 (37%), Positives = 45/80 (56%), Gaps = 1/80 (1%) Frame = +1 Query: 256 IHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTG 435 IH +++ N+L+ + DFGL +LI D + + + + APE +FG+ T Sbjct: 402 IHRDLRAANILVGERLVCKIADFGLARLIEDNEYNPRQGAKFPIKWTAPEAALFGRFTIK 461 Query: 436 CDVYSFGIILLELTS-GRKP 492 DV+SFGI+L EL S GR P Sbjct: 462 SDVWSFGILLTELISKGRVP 481
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 52.4 bits (124), Expect = 7e-07 Identities = 49/166 (29%), Positives = 76/166 (45%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSS-ECLLD 177 F E + + ++RH L+ L ++ P I V ++M SL L G H L+D Sbjct: 317 FLEEAQIMKKLRHDKLVPLYAVVSEEPIYI-VTEFMGKGSLLDFLKEGDGKHLKLPQLVD 375 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + IA G IH +++ N+L+ + + DFGL +LI D Sbjct: 376 MASQ--IADGMAFIERMNY-------IHRDLRAANILVADNLVCKIADFGLARLIEDNEY 426 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE ++G+ T DV+SFGI+L EL T GR P Sbjct: 427 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 472
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 52.4 bits (124), Expect = 7e-07 Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSEC----LLD 177 F AE + +++H L+ L P I+ +YM N SL L + LLD Sbjct: 284 FLAEANLMKQLQHPRLVRLYAVVTQEPIYIIT-EYMENGSLVDFLKTPSGIKLNVNKLLD 342 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + IA G IH +++ N+L+ + DFGL +LI D Sbjct: 343 MAAQ--IAEGMAFIEEQNY-------IHRDLRAANILVSDTLSCKIADFGLARLIEDNEY 393 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + +G T DV+SFGI+L E+ T GR P Sbjct: 394 TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP 439
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 52.4 bits (124), Expect = 7e-07 Identities = 36/162 (22%), Positives = 74/162 (45%), Gaps = 4/162 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL--HGTHSSECLLDWRRRT 192 E+ L + H+N+++ G +G + +Y+P S+ + L +G + ++ R+ Sbjct: 525 EMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQI 584 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLIS--DEIDHDK 366 I + IIH IK N+L+D + DFG+ K +S ++ + + Sbjct: 585 LIGVAYLHKKN---------IIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKR 635 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + + +PE V T D++S G +++E+ +G+ P Sbjct: 636 ASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHP 677
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 52.0 bits (123), Expect = 9e-07 Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E + V H +L+ L G C P LV MP+ L ++H S+ LL+W Sbjct: 765 FMDEALIMASVDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW 823 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLI-SDEID 357 + IA G ++H + + NVL+ S + DFGL +L+ DE + Sbjct: 824 CVQ--IAKGMMYLEERR-------LVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE 874 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 ++ G+ + A E + + K T DV+S+G+ + EL T G KP Sbjct: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKP 920
>JIL1_DROME (Q9V3I5) Chromosomal serine/threonine-protein kinase JIL-1 (EC| 2.7.11.1) Length = 1207 Score = 52.0 bits (123), Expect = 9e-07 Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 2/152 (1%) Frame = +1 Query: 43 RHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFIAIGXXXXX 222 R+ L+SL + LV D+ LF HL+ + + E + R R +IA Sbjct: 322 RNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFE---ESRVRVYIA----EVV 374 Query: 223 XXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAP 402 II+ IK N+LLD + + DFGL K+++ E ++ Y AP Sbjct: 375 LALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAP 434 Query: 403 EYVMFGKP--TTGCDVYSFGIILLELTSGRKP 492 E + G P + D +S G++ EL +G P Sbjct: 435 EIIRTGPPGHDSAVDWWSVGVLTFELLTGASP 466
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 52.0 bits (123), Expect = 9e-07 Identities = 44/163 (26%), Positives = 72/163 (44%), Gaps = 5/163 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E + +++ ++++S+ G C +V ++M + SL L THS L W + I Sbjct: 83 EAVKMEKIKFQHIVSIYGVCKQPLG--IVMEFMASGSLEKTLP-THS----LCWPLKLRI 135 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 I P++H +K N+LLD++ + DFGL K + I Sbjct: 136 -IHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERS 194 Query: 379 NQRG---YHAPEYVMFGKPTTG--CDVYSFGIILLELTSGRKP 492 RG Y PE + G DVYSF I++ E+ + +KP Sbjct: 195 ALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKKP 237
>EPHAA_HUMAN (Q5JZY3) Ephrin type-A receptor 10 precursor (EC 2.7.10.1)| Length = 1008 Score = 52.0 bits (123), Expect = 9e-07 Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F AE +LG+ H +++ L G G ++V +YM + +L L H + + Sbjct: 691 FLAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLR-RHEGQLVAGQLMG 749 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + +H + + +VL+ SD + FG E + + Sbjct: 750 LLPGLASAMKYLSEMGY-----VHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVYTTM 804 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 G + + APE + FG ++ DV+SFGII+ E+ + G +P Sbjct: 805 SGRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVMAFGERP 846
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 51.6 bits (122), Expect = 1e-06 Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 16/173 (9%) Frame = +1 Query: 10 FAAEVESLGRV-RHKNLLSLRGYCADGPERILVYDYMPNSSL---------------FAH 141 FA E+E L ++ H N+++L G C + + +Y P +L FA Sbjct: 884 FAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAR 943 Query: 142 LHGTHSSECLLDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGD 321 HGT S+ L R+ A IH + + NVL+ + + + D Sbjct: 944 EHGTAST---LSSRQLLRFA---SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIAD 997 Query: 322 FGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS 480 FGL + +E+ K +G + A E + + TT DV+SFG++L E+ S Sbjct: 998 FGLSR--GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS 1048
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 51.6 bits (122), Expect = 1e-06 Identities = 39/165 (23%), Positives = 74/165 (44%), Gaps = 4/165 (2%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL--HGTHSSECLLDWR 183 F E + R+ + N++++ ADG +V +Y+ +L + +G ++D+ Sbjct: 55 FKREASAAARIANANIVNIYDVGADGNVNYIVMEYVAGKTLKKLIKENGKIEFNKIIDYA 114 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI--D 357 + A+ + I+H IK N+++ D V DFG+ K ++ Sbjct: 115 TQIAKALNFAHK---------NGIVHRDIKPHNIMVTDDDIIKVTDFGIAKASNESTITT 165 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 +K++G Y +PE D+YSFGI+L E+ +G+ P Sbjct: 166 TNKVVGSAH--YLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVP 208
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 51.6 bits (122), Expect = 1e-06 Identities = 47/162 (29%), Positives = 69/162 (42%), Gaps = 4/162 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL--HGTHSSECLLDWRRRT 192 E+ + + H N+LSL L+ +Y LF L HG ++ R+ Sbjct: 77 EIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQI 136 Query: 193 FIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKII 372 I I I+H +K N+LLDS + + DFG+ L +D + Sbjct: 137 IIGISYCHALG---------IVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSC 187 Query: 373 GENQRGYHAPEYVMFGKPTTG--CDVYSFGIILLELTSGRKP 492 G Y APE ++ G P G DV+S G+IL L +GR P Sbjct: 188 GSPH--YAAPE-IVSGLPYEGFASDVWSCGVILFALLTGRLP 226
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 51.6 bits (122), Expect = 1e-06 Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 16/173 (9%) Frame = +1 Query: 10 FAAEVESLGRV-RHKNLLSLRGYCADGPERILVYDYMPNSSL---------------FAH 141 FA E+E L ++ H N+++L G C + + +Y P +L FA Sbjct: 882 FAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAR 941 Query: 142 LHGTHSSECLLDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGD 321 HGT S+ L R+ A IH + + NVL+ + + + D Sbjct: 942 EHGTAST---LSSRQLLRFA---SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIAD 995 Query: 322 FGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS 480 FGL + +E+ K +G + A E + + TT DV+SFG++L E+ S Sbjct: 996 FGLSR--GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS 1046
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 51.6 bits (122), Expect = 1e-06 Identities = 29/80 (36%), Positives = 45/80 (56%), Gaps = 1/80 (1%) Frame = +1 Query: 256 IHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTG 435 IH +++ N+L+ + + DFGL +LI D + + + APE ++G+ T Sbjct: 383 IHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 442 Query: 436 CDVYSFGIILLEL-TSGRKP 492 DV+SFGI+L EL T GR P Sbjct: 443 SDVWSFGILLTELVTKGRVP 462
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 51.6 bits (122), Expect = 1e-06 Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 16/173 (9%) Frame = +1 Query: 10 FAAEVESLGRV-RHKNLLSLRGYCADGPERILVYDYMPNSSL---------------FAH 141 FA E+E L ++ H N+++L G C + + +Y P +L FA Sbjct: 880 FAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAR 939 Query: 142 LHGTHSSECLLDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGD 321 HGT S+ L R+ A IH + + NVL+ + + + D Sbjct: 940 EHGTAST---LSSRQLLRFA---SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIAD 993 Query: 322 FGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS 480 FGL + +E+ K +G + A E + + TT DV+SFG++L E+ S Sbjct: 994 FGLSR--GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS 1044
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 51.6 bits (122), Expect = 1e-06 Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + + ++RH L+ L ++ P I V +YM SL L + L Sbjct: 310 FLQEAQIMKKLRHDKLVPLYAVVSEEPIYI-VTEYMIKGSLLDFLKEGNGKYLKLPQ--- 365 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH +++ N+L+ + + DFGL +LI D + Sbjct: 366 --LVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQ 423 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + + APE ++G+ T DV+SFGI+L EL + GR P Sbjct: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVAKGRVP 465
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 51.6 bits (122), Expect = 1e-06 Identities = 29/80 (36%), Positives = 45/80 (56%), Gaps = 1/80 (1%) Frame = +1 Query: 256 IHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTG 435 IH +++ N+L+ + + DFGL +LI D + + + APE ++G+ T Sbjct: 390 IHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 449 Query: 436 CDVYSFGIILLEL-TSGRKP 492 DV+SFGI+L EL T GR P Sbjct: 450 SDVWSFGILLTELVTKGRVP 469
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 51.6 bits (122), Expect = 1e-06 Identities = 39/167 (23%), Positives = 75/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E +G+ H N++ L G +++ ++M N +L + L + D + Sbjct: 655 FLGEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDSFLR-------MNDGQFT 707 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLI----SDEI 354 +G + +H + + N+L++S+ V DFGL + + SD Sbjct: 708 VIQLVGILRGIASGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLENSRSDPT 767 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + APE + + K T+ DV+S+GI++ E+ S G +P Sbjct: 768 YTSALGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMSYGERP 814
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 51.2 bits (121), Expect = 1e-06 Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 16/173 (9%) Frame = +1 Query: 10 FAAEVESLGRVR-HKNLLSLRGYCADGPERILVYDYMPNSSL---------------FAH 141 FA E+E L R+ HKN++ L G C L ++ P+ +L FA Sbjct: 861 FAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAI 920 Query: 142 LHGTHSSECLLDWRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGD 321 H T S+ L + F A IH + + NVL+ +F A + D Sbjct: 921 AHRTAST--LSSQQLLAFSA----DVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIAD 974 Query: 322 FGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS 480 FGL + E+ K +G + A E + + TT DV+S+G++L E+ S Sbjct: 975 FGLSR--GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVS 1025
>NRBP_MOUSE (Q99J45) Nuclear receptor-binding protein (MLF1 adapter molecule)| (HLS7-interacting protein kinase) Length = 535 Score = 51.2 bits (121), Expect = 1e-06 Identities = 47/163 (28%), Positives = 70/163 (42%), Gaps = 10/163 (6%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPER----ILVYDYMPNSSLFAHLHGTHSSECLLD-- 177 A ++L ++ H N++ Y AD E I + +YM + SL L T + ++ Sbjct: 116 AVFDNLIQLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEK 175 Query: 178 -WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 W+R + PIIHG N+ D+ F H G + + D I Sbjct: 176 AWKRWCTQILSALSYLHSCD----PPIIHG-----NLTCDTIFIQHNGLIKIGSVAPDTI 226 Query: 355 D-HDKIIGENQRGYH--APEYVMFGKPTTGCDVYSFGIILLEL 474 + H K E Q+ H APEY TT D+YSFG+ LE+ Sbjct: 227 NNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEM 269
>GCY3E_DROME (Q07553) Guanylate cyclase 32E precursor (EC 4.6.1.2)| Length = 1163 Score = 51.2 bits (121), Expect = 1e-06 Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 6/164 (3%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + VRH+N+++ G D I+ Y SL L + + LD FI Sbjct: 575 ELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLA---NEDLHLD---HMFI 628 Query: 199 AIGXXXXXXXXXXXXTSPII-HGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIG 375 + S II HG+++S+N L+DS + + DFGL +L + + + +K Sbjct: 629 SSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSEL 688 Query: 376 ENQRGY-HAPEYVMF----GKPTTGCDVYSFGIILLELTSGRKP 492 E +R APE + G+ + DVYSFGI+L E+ + P Sbjct: 689 ELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGP 732
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 51.2 bits (121), Expect = 1e-06 Identities = 41/166 (24%), Positives = 72/166 (43%), Gaps = 8/166 (4%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E + ++H+N+ +LRG C + + LV +Y SL L G + L++W Sbjct: 189 EAKLFWALKHENIAALRGVCLN-TKLCLVMEYARGGSLNRILAGKIPPDVLVNW------ 241 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAH--------VGDFGLMKLISDEI 354 AI IIH +KS+NVL+ + + + DFGL + + Sbjct: 242 AIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR---EMY 298 Query: 355 DHDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + ++ + PE + + DV+S+G++L EL +G P Sbjct: 299 NTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETP 344
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 51.2 bits (121), Expect = 1e-06 Identities = 49/211 (23%), Positives = 85/211 (40%), Gaps = 50/211 (23%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSL--FAHLHGTHSSECLLDWR 183 F E E L ++H++++ G C DG I+V++YM + L F HG + + Sbjct: 585 FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 644 Query: 184 RRTFIAIGXXXXXXXXXXXXTSPI-------IHGSIKSTNVLLDSDFQAHVGDFGLMKLI 342 R+ +G + + +H + + N L+ ++ +GDFG+ + + Sbjct: 645 RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV 704 Query: 343 SD-----EIDHDK----IIGENQR-----------------------GYHA--------P 402 E + K + + QR G H P Sbjct: 705 YSTDYYREGPYQKGPFSVSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRWMPP 764 Query: 403 EYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 E +M+ K TT DV+SFG+IL E+ T G++P Sbjct: 765 ESIMYRKFTTESDVWSFGVILWEIFTYGKQP 795
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 50.8 bits (120), Expect = 2e-06 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++H NL+ L G C P ++ ++M +L +L EC Sbjct: 283 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-----ECNRQEVNA 337 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH + + N L+ + V DFGL +L++ + Sbjct: 338 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHA 397 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + K + DV++FG++L E+ T G P Sbjct: 398 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 439
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 50.8 bits (120), Expect = 2e-06 Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLH---GTHSSECLLDW 180 F E + + H +L+ L G C P LV MP+ L ++H S+ LL+W Sbjct: 765 FMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW 823 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLI-SDEID 357 + IA G ++H + + NVL+ S + DFGL +L+ DE + Sbjct: 824 CVQ--IAKGMMYLEERR-------LVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE 874 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 ++ G+ + A E + + K T DV+S+G+ + EL T G KP Sbjct: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKP 920
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 50.8 bits (120), Expect = 2e-06 Identities = 48/161 (29%), Positives = 75/161 (46%), Gaps = 6/161 (3%) Frame = +1 Query: 28 SLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL---HGTHSSECLLDWRRRTFI 198 ++G + H +++ L G C G LV Y+P SL H+ T + LL+W + I Sbjct: 760 AVGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQ--I 816 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A G ++H + NV+L S Q V DFG+ L+ + D + E Sbjct: 817 AKGMYYLEEHS-------MVHRDLALRNVMLKSPSQVQVADFGVADLLPPD-DKQLLHSE 868 Query: 379 NQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + A E + FGK T DV+S+G+ + EL T G +P Sbjct: 869 AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEP 909
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 50.8 bits (120), Expect = 2e-06 Identities = 48/161 (29%), Positives = 75/161 (46%), Gaps = 6/161 (3%) Frame = +1 Query: 28 SLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHG---THSSECLLDWRRRTFI 198 ++G + H +++ L G C G LV Y+P SL H+ T + LL+W + I Sbjct: 760 AVGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQ--I 816 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A G ++H + NV+L S Q V DFG+ L+ + D + E Sbjct: 817 AKGMYYLEEHS-------MVHRDLALRNVMLKSPSQVQVADFGVADLLPPD-DKQLLHSE 868 Query: 379 NQR--GYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + A E + FGK T DV+S+G+ + EL T G +P Sbjct: 869 AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEP 909
>KSS1_YEAST (P14681) Mitogen-activated protein kinase KSS1 (EC 2.7.11.24) (MAP| kinase KSS1) (Kinase suppressor of SST2) Length = 368 Score = 50.8 bits (120), Expect = 2e-06 Identities = 31/88 (35%), Positives = 51/88 (57%), Gaps = 7/88 (7%) Frame = +1 Query: 244 TSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID-HDKIIG-----ENQRGYHAPE 405 ++ +IH IK +N+LL+S+ V DFGL + ++ D + ++G R Y APE Sbjct: 136 SAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPE 195 Query: 406 YVM-FGKPTTGCDVYSFGIILLELTSGR 486 ++ F + TT D++S G IL E+ SG+ Sbjct: 196 IMLTFQEYTTAMDIWSCGCILAEMVSGK 223
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 50.8 bits (120), Expect = 2e-06 Identities = 46/173 (26%), Positives = 77/173 (44%), Gaps = 15/173 (8%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E + + R+RH ++ L G + LV +YM +L H+ T + L + R + Sbjct: 63 EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLM-HVLKTQI-DVPLSLKGRIIV 120 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLM------KLISDEIDH 360 +IH +K N+L+D DF + D G+ KL ++ + Sbjct: 121 E-----AIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNK 175 Query: 361 DKIIG----ENQRG---YHAPEYV--MFGKPTTGCDVYSFGIILLELTSGRKP 492 K + +N G Y APE++ + KPT DVYSFGI+L + + ++P Sbjct: 176 QKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEP 228
>ANPRA_RAT (P18910) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 50.8 bits (120), Expect = 2e-06 Identities = 41/156 (26%), Positives = 70/156 (44%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V++++L G C D P ++ +Y P SL L + LDW R Sbjct: 579 ELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILE---NESITLDWMFR--Y 633 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 ++ + HG++KS+N ++D F + D+GL E + + Sbjct: 634 SLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFA 693 Query: 379 NQRGYHAPEYVMFGKP----TTGCDVYSFGIILLEL 474 ++ + APE + P + DVYSFGIIL E+ Sbjct: 694 -KKLWTAPELLRMASPPARGSQAGDVYSFGIILQEI 728
>ANPRA_MOUSE (P18293) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 50.8 bits (120), Expect = 2e-06 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 4/156 (2%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 E++ + V++++L G C D P ++ +Y P SL L + LDW R + Sbjct: 579 ELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILE---NESITLDWMFRYSL 635 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 HG++KS+N ++D F + D+GL E + + Sbjct: 636 TNDIVKGMLFLHNGAIGS--HGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFA 693 Query: 379 NQRGYHAPEYVMFGKP----TTGCDVYSFGIILLEL 474 ++ + APE + P + DVYSFGIIL E+ Sbjct: 694 -KKLWTAPELLRMASPPARGSQAGDVYSFGIILQEI 728
>NRBP_PONPY (Q5RBH9) Nuclear receptor-binding protein| Length = 535 Score = 50.8 bits (120), Expect = 2e-06 Identities = 47/163 (28%), Positives = 70/163 (42%), Gaps = 10/163 (6%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPER----ILVYDYMPNSSLFAHLHGTHSSECLLD-- 177 A ++L ++ H N++ Y AD E I + +YM + SL L T + ++ Sbjct: 116 AVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEK 175 Query: 178 -WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 W+R + PIIHG N+ D+ F H G + + D I Sbjct: 176 AWKRWCTQILSALSYLHSCD----PPIIHG-----NLTCDTIFIQHNGLIKIGSVAPDTI 226 Query: 355 D-HDKIIGENQRGYH--APEYVMFGKPTTGCDVYSFGIILLEL 474 + H K E Q+ H APEY TT D+YSFG+ LE+ Sbjct: 227 NNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEM 269
>NRBP_MACFA (Q4R8X0) Nuclear receptor-binding protein| Length = 535 Score = 50.8 bits (120), Expect = 2e-06 Identities = 47/163 (28%), Positives = 70/163 (42%), Gaps = 10/163 (6%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPER----ILVYDYMPNSSLFAHLHGTHSSECLLD-- 177 A ++L ++ H N++ Y AD E I + +YM + SL L T + ++ Sbjct: 116 AVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEK 175 Query: 178 -WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 W+R + PIIHG N+ D+ F H G + + D I Sbjct: 176 AWKRWCTQILSALSYLHSCD----PPIIHG-----NLTCDTIFIQHNGLIKIGSVAPDTI 226 Query: 355 D-HDKIIGENQRGYH--APEYVMFGKPTTGCDVYSFGIILLEL 474 + H K E Q+ H APEY TT D+YSFG+ LE+ Sbjct: 227 NNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEM 269
>NRBP_HUMAN (Q9UHY1) Nuclear receptor-binding protein| Length = 535 Score = 50.8 bits (120), Expect = 2e-06 Identities = 47/163 (28%), Positives = 70/163 (42%), Gaps = 10/163 (6%) Frame = +1 Query: 16 AEVESLGRVRHKNLLSLRGYCADGPER----ILVYDYMPNSSLFAHLHGTHSSECLLD-- 177 A ++L ++ H N++ Y AD E I + +YM + SL L T + ++ Sbjct: 116 AVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEK 175 Query: 178 -WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEI 354 W+R + PIIHG N+ D+ F H G + + D I Sbjct: 176 AWKRWCTQILSALSYLHSCD----PPIIHG-----NLTCDTIFIQHNGLIKIGSVAPDTI 226 Query: 355 D-HDKIIGENQRGYH--APEYVMFGKPTTGCDVYSFGIILLEL 474 + H K E Q+ H APEY TT D+YSFG+ LE+ Sbjct: 227 NNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEM 269
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/167 (21%), Positives = 74/167 (44%), Gaps = 6/167 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F +E +G+ H N++ L G +++ ++M N +L + L ++ Sbjct: 666 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ---- 721 Query: 190 TFIAIGXXXXXXXXXXXXTSP-IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH-- 360 +G + +H + + N+L++S+ V DFGL + + D+ Sbjct: 722 ---LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 778 Query: 361 --DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS-GRKP 492 + G+ + A E + + K T+ DV+S+GI++ E+ S G +P Sbjct: 779 YTSSLGGKIPVRWTAQEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 825
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 50.4 bits (119), Expect = 3e-06 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++H NL+ L G C P ++ ++M +L +L EC Sbjct: 169 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-----ECNRQEVSA 223 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH + + N L+ + V DFGL +L++ + Sbjct: 224 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHA 283 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + K + DV++FG++L E+ T G P Sbjct: 284 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 325
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 50.4 bits (119), Expect = 3e-06 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++H NL+ L G C P ++ ++M +L +L EC Sbjct: 283 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-----ECNRQEVSA 337 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH + + N L+ + V DFGL +L++ + Sbjct: 338 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHA 397 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + K + DV++FG++L E+ T G P Sbjct: 398 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 439
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 50.4 bits (119), Expect = 3e-06 Identities = 47/178 (26%), Positives = 74/178 (41%), Gaps = 17/178 (9%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPE--RILVYDYMPNSSLFAHLHGTHSSECLLDWR 183 F EV L ++RH N++ G C G E +V ++M SL L + LL+ Sbjct: 1332 FQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFN---LLEQN 1388 Query: 184 RRTFIAIGXXXXXXXXXXXX-TSPIIHGSIKSTNVLLD-------------SDFQAHVGD 321 + + T PI+H + S N+LLD D + + D Sbjct: 1389 PHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISD 1448 Query: 322 FGLMKLISDEIDH-DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 FGL +L ++ + +G Y APE + DVYS+G++L EL + +P Sbjct: 1449 FGLSRLKKEQASQMTQSVGCIP--YMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEP 1504
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 50.1 bits (118), Expect = 3e-06 Identities = 42/158 (26%), Positives = 64/158 (40%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 EVE +RH N+L L GY D L+ DY P LF L +C +R+ Sbjct: 188 EVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFREL-----QKCTRFDDQRS-- 240 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 A+ + +IH IK N+LL S+ + + DFG + + + G Sbjct: 241 ALYIKQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFG-WSVHAPSSRRTTLCG- 298 Query: 379 NQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 Y PE + D++S G++ E G+ P Sbjct: 299 -TLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP 335
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 50.1 bits (118), Expect = 3e-06 Identities = 40/160 (25%), Positives = 71/160 (44%) Frame = +1 Query: 1 KWXFAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDW 180 K F E L + H N++ L G C ++V + + SL +L + L Sbjct: 1103 KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG---LTT 1159 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R++ + + IH + + N L+D + + DFG+ + + I Sbjct: 1160 RQQMGMC---RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVS 1216 Query: 361 DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTS 480 D + + + APE + FGK T+ CDV+S+GI++ E+ S Sbjct: 1217 DGM-KQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFS 1255
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 50.1 bits (118), Expect = 3e-06 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++H NL+ L G C P ++ ++M +L +L EC Sbjct: 232 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-----ECNRQEVNA 286 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 + IH + + N L+ + V DFGL +L++ + Sbjct: 287 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHA 346 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + + K + DV++FG++L E+ T G P Sbjct: 347 GTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 388
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 50.1 bits (118), Expect = 3e-06 Identities = 42/158 (26%), Positives = 62/158 (39%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRRTFI 198 EVE +RH N+L L GY D L+ DY P LF L + D R +I Sbjct: 188 EVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFD---DQRSAMYI 244 Query: 199 AIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGE 378 + +IH IK N+LL S+ + + DFG + + + G Sbjct: 245 ----KQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFG-WSVHAPSSRRTTLCG- 298 Query: 379 NQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 Y PE + D++S G++ E G+ P Sbjct: 299 -TLDYLPPEMIEGRMHDETVDLWSLGVLCYEFLVGKPP 335
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 49.7 bits (117), Expect = 4e-06 Identities = 28/80 (35%), Positives = 45/80 (56%), Gaps = 1/80 (1%) Frame = +1 Query: 256 IHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTG 435 IH +++ N+L+ + + DFGL +LI D + + + APE ++G+ T Sbjct: 388 IHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 447 Query: 436 CDVYSFGIILLELTS-GRKP 492 DV+SFGI+ ELT+ GR P Sbjct: 448 SDVWSFGILQTELTTKGRVP 467
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 49.7 bits (117), Expect = 4e-06 Identities = 29/81 (35%), Positives = 46/81 (56%), Gaps = 1/81 (1%) Frame = +1 Query: 253 IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTT 432 ++H + + N+L+ D A V DFGL K +D ++ + + APE + GK T+ Sbjct: 348 LVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK----WTAPEALKHGKFTS 403 Query: 433 GCDVYSFGIILLELTS-GRKP 492 DV+SFG++L E+ S GR P Sbjct: 404 KSDVWSFGVLLWEVFSYGRAP 424
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 49.7 bits (117), Expect = 4e-06 Identities = 46/168 (27%), Positives = 71/168 (42%), Gaps = 7/168 (4%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F EV L + RH N+L G+ + PE ++ + SSL+ H+H E +++ Sbjct: 522 FKNEVAVLKKTRHLNVLLFMGWVRE-PEIAIITQWCEGSSLYRHIH---VQEPRVEFEMG 577 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQA-HVGDFGLMKLISDEIDHDK 366 I I + IIH +K+ N+ L D +GDFGL + + + Sbjct: 578 AIIDI-LKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGG 636 Query: 367 IIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 + G + APE + T DVYSFGI + E+ S P Sbjct: 637 QQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLP 684
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 49.7 bits (117), Expect = 4e-06 Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGT---HSSECLLDW 180 F E +S + H N++S+ + +V +Y+ +L ++ H E L Sbjct: 56 FRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALNIM 115 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDE-ID 357 + + I+H IK N+L+D V DFG+ +S I Sbjct: 116 EQ----------IVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTIT 165 Query: 358 H-DKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 H + ++G Y +PE G T D+Y+ GI+L EL +GR P Sbjct: 166 HTNSVLGSVH--YLSPEQARGGLATKKSDIYALGIVLFELLTGRIP 209
>PMYT1_CAEEL (O18209) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) (Lethal protein 37) Length = 677 Score = 49.7 bits (117), Expect = 4e-06 Identities = 29/79 (36%), Positives = 44/79 (55%) Frame = +1 Query: 244 TSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGK 423 ++ +IH IK N+ L D +GDFGL+ + + D K E Y APE V+ G+ Sbjct: 221 SNDMIHDDIKPENIFLTKDMICKLGDFGLVINLKNPND-VKSAEEGDSKYLAPE-VLNGR 278 Query: 424 PTTGCDVYSFGIILLELTS 480 PT D++S G+ +LE T+ Sbjct: 279 PTKSSDIFSLGMTILEATT 297
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 49.3 bits (116), Expect = 6e-06 Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 7/163 (4%) Frame = +1 Query: 19 EVESLGRVRHKNLLSL----RGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRR 186 E++ L R +H+N++++ R D + I + + + L+ L S Sbjct: 142 EIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSN------- 194 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 + ++ ++H +K +N+LL++ + DFGL ++ + DH Sbjct: 195 -DHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTG 253 Query: 367 IIGE--NQRGYHAPEYVMFGKP-TTGCDVYSFGIILLELTSGR 486 + E R Y APE ++ K T DV+S G IL E+ S R Sbjct: 254 FLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNR 296
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 49.3 bits (116), Expect = 6e-06 Identities = 39/162 (24%), Positives = 64/162 (39%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHG-THSSECLLDWRR 186 F EVE +RH NL L GY D L+ +Y+ N L+ HL G +H ++ + + Sbjct: 154 FRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYY- 212 Query: 187 RTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDK 366 I+H IK N+++ + + DFG + Sbjct: 213 -------VYQMADALDYMHERNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSKRKT 265 Query: 367 IIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLELTSGRKP 492 + G Y +PE + + DV++ G++ EL G P Sbjct: 266 LCGTVD--YLSPELIRSREYNEKVDVWALGVLTYELLVGSPP 305
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 49.3 bits (116), Expect = 6e-06 Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSS---ECLLDW 180 F E++ L + RH N+L G+ P ++ + SSL+ HLH + L+D Sbjct: 349 FKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDV 407 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + + Sbjct: 408 ARQT---------AQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGA 458 Query: 361 DKIIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 + E G + A E + P + DVY++G++L EL +G P Sbjct: 459 QPL--EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLP 506
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 49.3 bits (116), Expect = 6e-06 Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 9/170 (5%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSS---ECLLDW 180 F E++ L + RH N+L G+ P ++ + SSL+ HLH + L+D Sbjct: 349 FKNEMQVLRKTRHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDV 407 Query: 181 RRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDH 360 R+T IIH +KS N+ L +GDFGL + + Sbjct: 408 ARQT---------AQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGA 458 Query: 361 DKIIGENQRG---YHAPEYVMFGKP---TTGCDVYSFGIILLELTSGRKP 492 + E G + A E + P + DVY++G++L EL +G P Sbjct: 459 QPL--EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLP 506
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 49.3 bits (116), Expect = 6e-06 Identities = 42/162 (25%), Positives = 67/162 (41%), Gaps = 1/162 (0%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTHSSECLLDWRRR 189 F E + ++H L+ L ++ ++M SL L S+ LL + Sbjct: 286 FLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGSKVLLP-KLI 344 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 F A IH +++ NVL+ + DFGL ++I D + Sbjct: 345 DFSA----QIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTARE 400 Query: 370 IGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + APE + FG T DV+SFGI+L E+ T G+ P Sbjct: 401 GAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP 442
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 49.3 bits (116), Expect = 6e-06 Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 11/169 (6%) Frame = +1 Query: 19 EVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHL--HG-THSSECLLDWRRR 189 E+++L RH +++ L + + +V +Y+ LF ++ HG E RR Sbjct: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEA-----RR 118 Query: 190 TFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKI 369 F I ++H +K NVLLD+ A + DFGL ++SD Sbjct: 119 LFQQI-----LSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSD------- 166 Query: 370 IGENQR------GYHAPEYVMFGKPTTG--CDVYSFGIILLELTSGRKP 492 GE R Y APE V+ G+ G D++S G+IL L G P Sbjct: 167 -GEFLRTSCGSPNYAAPE-VISGRLYAGPEVDIWSCGVILYALLCGTLP 213
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 49.3 bits (116), Expect = 6e-06 Identities = 26/80 (32%), Positives = 46/80 (57%) Frame = +1 Query: 253 IIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTT 432 I+H +K +N+L++S+ + + DFG+ ++ D + + + R Y APE + T Sbjct: 191 ILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFV---GTRSYMAPERLTGSHYTI 247 Query: 433 GCDVYSFGIILLELTSGRKP 492 D++SFG+ L+EL GR P Sbjct: 248 SSDIWSFGLSLVELLIGRYP 267
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 49.3 bits (116), Expect = 6e-06 Identities = 48/166 (28%), Positives = 71/166 (42%), Gaps = 5/166 (3%) Frame = +1 Query: 10 FAAEVESLGRVRHKNLLSLRGYCADGPERILVYDYMPNSSLFAHLHGTH----SSECLLD 177 F AE + ++H L+ L P I+ +YM SL L + S LLD Sbjct: 283 FLAEANLMKNLQHPRLVRLYAVVTKEPIYIIT-EYMEKGSLVDFLKTSEGIKLSINKLLD 341 Query: 178 WRRRTFIAIGXXXXXXXXXXXXTSPIIHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEID 357 + IA G IH +++ N+L+ + DFGL +LI D Sbjct: 342 MAAQ--IAEGMAFIEAKNY-------IHRDLRAANILVSEALCCKIADFGLARLIEDNEY 392 Query: 358 HDKIIGENQRGYHAPEYVMFGKPTTGCDVYSFGIILLEL-TSGRKP 492 + + + APE + +G T DV+SFGI+L E+ T GR P Sbjct: 393 TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTYGRIP 438
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 49.3 bits (116), Expect = 6e-06 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 1/80 (1%) Frame = +1 Query: 256 IHGSIKSTNVLLDSDFQAHVGDFGLMKLISDEIDHDKIIGENQRGYHAPEYVMFGKPTTG 435 IH +++ N+L+ + + DFGL +LI D + + + APE ++G+ T Sbjct: 392 IHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 451 Query: 436 CDVYSFGIILLEL-TSGRKP 492 DV+SFGI+ EL T GR P Sbjct: 452 SDVWSFGILQTELVTKGRVP 471 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 75,560,643 Number of Sequences: 219361 Number of extensions: 1582069 Number of successful extensions: 6369 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5183 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5493 length of database: 80,573,946 effective HSP length: 103 effective length of database: 57,979,763 effective search space used: 3478785780 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
