ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags31i19 |
|---|---|
| Clone Library Name | barley_pub |
>MAK_MOUSE (Q04859) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) (Protein kinase RCK) Length = 622 Score = 236 bits (603), Expect = 2e-62 Identities = 109/169 (64%), Positives = 142/169 (84%), Gaps = 1/169 (0%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 END L+FVFEYM+ NLYQLMK + K F E+ IRN +Q+ Q L+ +H+ G+FHRD+KPEN Sbjct: 71 ENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPEN 130 Query: 214 LL-VTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LL + EL+K+ADFGLARE+ S+PPYT+YVSTRWYRAPEVLL+SSVYSS +D+WA+G+I+ Sbjct: 131 LLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIM 190 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 AEL++ RPLFPG+SE DEI+KIC +LGTP + W G QLA+S++F+FP Sbjct: 191 AELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFP 239
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 236 bits (602), Expect = 3e-62 Identities = 108/169 (63%), Positives = 142/169 (84%), Gaps = 1/169 (0%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 END L+F+FEYM+ NLYQLMK + K F E+ IRN +Q+ Q L+ +H+ G+FHRD+KPEN Sbjct: 71 ENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPEN 130 Query: 214 LL-VTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LL + EL+K+ADFGLARE+ S+PPYT+YVSTRWYRAPEVLL+SSVYSS +D+WA+G+I+ Sbjct: 131 LLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIM 190 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 AEL++ RPLFPG+SE DEI+KIC +LGTP + W G QLA+S++F+FP Sbjct: 191 AELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFP 239
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 234 bits (598), Expect = 9e-62 Identities = 108/169 (63%), Positives = 141/169 (83%), Gaps = 1/169 (0%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 END L+F+FEYM+ NLYQLMK + K F E+ IRN +Q+ Q L+ +H+ G+FHRD+KPEN Sbjct: 71 ENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPEN 130 Query: 214 LL-VTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LL + EL+K+ADFGLARE+ S+PPYT+YVSTRWYRAPEVLL+SSVYSS +D+WA+G+I+ Sbjct: 131 LLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIM 190 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 AEL+ RPLFPG+SE DEI+KIC +LGTP + W G QLA+S++F+FP Sbjct: 191 AELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFP 239
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 223 bits (567), Expect = 3e-58 Identities = 102/169 (60%), Positives = 139/169 (82%), Gaps = 1/169 (0%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 END L+F+FEYM+ NLYQL+K + K F E+ IRN +Q+ Q L+ +H+ G+FHRDLKPEN Sbjct: 71 ENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130 Query: 214 LL-VTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LL + EL+K+ADFGLAREI S+PPYT+YVSTRWYRAPEVLL+S+ YSS +D+WA+G I+ Sbjct: 131 LLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIM 190 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 AE+++ RPLFPG+SE D I+KIC +LGTP + W G QL+++++F++P Sbjct: 191 AEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWP 239
>MHK_ARATH (P43294) Serine/threonine-protein kinase MHK (EC 2.7.11.22)| Length = 443 Score = 222 bits (565), Expect = 6e-58 Identities = 107/171 (62%), Positives = 136/171 (79%), Gaps = 3/171 (1%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 E++ LFF+FE M+ NLY +MK + +PFSE EIR++ Q+ Q L+HMH+ GYFHRDLKPEN Sbjct: 79 EHNELFFIFECMDHNLYHIMKERERPFSEGEIRSFMSQMLQGLAHMHKNGYFHRDLKPEN 138 Query: 214 LLVTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 LLVT ++K+ADFGLARE+ S PPYTEYVSTRWYRAPEVLLQSS+Y+ AVDMWA+GAI+A Sbjct: 139 LLVTNNILKIADFGLAREVASMPPYTEYVSTRWYRAPEVLLQSSLYTPAVDMWAVGAILA 198 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTW--AGGLQLAASI-HFQFP 537 EL++ PLFPG SE D++YKIC +LG P+ T+ A + SI H +FP Sbjct: 199 ELYALTPLFPGESEIDQLYKICCVLGKPDWTTFPEAKSISRIMSISHTEFP 249
>ICK_MOUSE (Q9JKV2) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) Length = 629 Score = 221 bits (563), Expect = 1e-57 Identities = 102/169 (60%), Positives = 137/169 (81%), Gaps = 1/169 (0%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 END L+F+FEYM+ NLYQL+K + K F E+ IRN +Q+ Q L+ +H+ G+FHRDLKPEN Sbjct: 71 ENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130 Query: 214 LL-VTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LL + EL+K+ADFGLAREI S PPYT+YVSTRWYRAPEVLL+S+ YSS +D+WA+G I+ Sbjct: 131 LLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIM 190 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 AE+++ RPLFPG+SE D I+KIC +LGTP + W G QL+++++F +P Sbjct: 191 AEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWP 239
>ICK_RAT (Q62726) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (MAK-related kinase) (MRK) Length = 629 Score = 221 bits (562), Expect = 1e-57 Identities = 102/169 (60%), Positives = 137/169 (81%), Gaps = 1/169 (0%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 END L+F+FEYM+ NLYQL+K + K F E+ IRN +Q+ Q L+ +H+ G+FHRDLKPEN Sbjct: 71 ENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130 Query: 214 LL-VTKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LL + EL+K+ADFGLAREI S PPYT+YVSTRWYRAPEVLL+S+ YSS +D+WA+G I+ Sbjct: 131 LLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIM 190 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 AE+++ RPLFPG+SE D I+KIC +LGTP + W G QL+++++F +P Sbjct: 191 AEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWP 239
>PIT1_SCHPO (O14132) Sporulation protein kinase pit1 (EC 2.7.11.1)| Length = 650 Score = 166 bits (421), Expect = 3e-41 Identities = 75/155 (48%), Positives = 114/155 (73%), Gaps = 7/155 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKS-KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L V E+++CNLYQL+ + K P + ++++ Q+F+ L+H+H G+FHRD+KPEN+L+ Sbjct: 110 LHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILI 169 Query: 223 TKEL------IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 + +K+ADFGLAREI S PPYTEYVSTRWYRAPE+LL+ S YS VD++A G Sbjct: 170 SSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGC 229 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQHT 489 + E+ + +P+FPG+ + D++YK+C ILG+P++ + Sbjct: 230 MAFEIATLQPIFPGNDDFDQLYKMCEILGSPDEQS 264
>MDE3_SCHPO (O43077) Sporulation protein kinase mde3 (EC 2.7.11.1)| (Mei4-dependent protein 3) Length = 559 Score = 162 bits (411), Expect = 4e-40 Identities = 78/180 (43%), Positives = 115/180 (63%), Gaps = 16/180 (8%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK-GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 +F V E+M+CNL+QL K + G+ F++ N Q+ + H+H+ G+ HRD+KPEN+LV Sbjct: 99 IFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILV 158 Query: 223 ---------TKELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWA 375 ++ IK+ DFGLAR +S P TEYVSTRWYRAPE+LL+S Y+ +VD++A Sbjct: 159 KRISPKPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYA 218 Query: 376 MGAIIAELFSHRPLFPGSSEADEIYKICNILGTP------NQHTWAGGLQLAASIHFQFP 537 G I+ E++S +PLFPG +E D++ ++C ILG P H W+ +LA + F P Sbjct: 219 FGCIVFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLP 278
>MOK_MOUSE (Q9WVS4) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) Length = 420 Score = 160 bits (404), Expect = 3e-39 Identities = 73/164 (44%), Positives = 112/164 (68%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L + E M+ N+Y+L++ + P SE +I + +Q+ ++L HMH+ G FHRD+KPEN+LV Sbjct: 78 LALICELMDMNIYELIRGRRHPLSEKKIMLYMYQLCKSLDHMHRNGIFHRDVKPENILVK 137 Query: 226 KELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 ++++K+ DFG R + S+ PYTEY+STRWYRAPE LL Y+ +D+W+ G + E+ S Sbjct: 138 QDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIAS 197 Query: 406 HRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 +PLFPG +E D+I KI +++GTP Q T Q + ++ F FP Sbjct: 198 LQPLFPGVNELDQISKIHDVIGTPCQKTLTKFKQ-SRAMSFDFP 240
>MOK_HUMAN (Q9UQ07) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) (Renal tumor antigen 1) (RAGE-1) Length = 419 Score = 158 bits (399), Expect = 1e-38 Identities = 70/164 (42%), Positives = 113/164 (68%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L + E M+ N+Y+L++ + P SE +I ++ +Q+ ++L H+H+ G FHRD+KPEN+L+ Sbjct: 78 LALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIK 137 Query: 226 KELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 ++++K+ DFG R + S+ PYTEY+STRWYRAPE LL Y+ +D+W+ G + E+ S Sbjct: 138 QDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIAS 197 Query: 406 HRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 +PLFPG +E D+I KI +++GTP Q Q + +++F FP Sbjct: 198 LQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQ-SRAMNFDFP 240
>IME2_YEAST (P32581) Meiosis induction protein kinase IME2/SME1 (EC 2.7.11.1)| Length = 645 Score = 151 bits (382), Expect = 1e-36 Identities = 76/167 (45%), Positives = 105/167 (62%), Gaps = 19/167 (11%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKP-FSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 EN L V E ME NLYQ+MK + + FS +++ Q+ L H+H+ +FHRDLKPE Sbjct: 138 ENYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPE 197 Query: 211 NLLVTKE------------------LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 N+L+T +IK+ADFGLAR + ++ PYT YVSTRWYR+PE+LL Sbjct: 198 NILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILL 257 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 +S YS +D+WA G + E+ R LFPG++E D+I+KI +LGTP Sbjct: 258 RSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTP 304
>CD2L2_HUMAN (Q9UQ88) PITSLRE serine/threonine-protein kinase CDC2L2 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11) Length = 780 Score = 142 bits (357), Expect = 8e-34 Identities = 71/159 (44%), Positives = 102/159 (64%), Gaps = 2/159 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 D ++ V Y+E +L LM++ +PF E++ Q+ + + H+H HRDLK NLL Sbjct: 495 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 554 Query: 220 VTKE-LIKVADFGLAREIISE-PPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 ++ ++KV DFGLARE S YT V T+WYRAPE+LL + YS+AVDMW++G I Sbjct: 555 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFG 614 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 EL + +PLFPG+SE D+I K+ LGTP++ W G +L Sbjct: 615 ELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSEL 653
>CD2L1_HUMAN (P21127) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1) Length = 795 Score = 141 bits (356), Expect = 1e-33 Identities = 72/161 (44%), Positives = 101/161 (62%), Gaps = 2/161 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 D ++ V Y+E +L LM++ +PF E++ Q+ + + H+H HRDLK NLL Sbjct: 510 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 569 Query: 220 VTKE-LIKVADFGLAREIISE-PPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 ++ ++KV DFGLARE S YT V T WYRAPE+LL + YS+AVDMW++G I Sbjct: 570 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 629 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAA 516 EL + +PLFPG SE D+I K+ LGTP++ W G +L A Sbjct: 630 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPA 670
>CDC22_ORYSA (P29619) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 292 Score = 141 bits (355), Expect = 1e-33 Identities = 67/154 (43%), Positives = 103/154 (66%), Gaps = 3/154 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ VFEY++ +L + M S + ++++ +Q+ + +++ H HRDLKP+NLL+ Sbjct: 76 IYLVFEYLDLDLKKHMDSSPDFKNHRIVKSFLYQILRGIAYCHSHRVLHRDLKPQNLLID 135 Query: 226 KEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 + +K+ADFGLAR I +T V T WYRAPE+LL + YS+ VDMW++G I AE Sbjct: 136 RRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGARHYSTPVDMWSVGCIFAE 195 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 + + +PLFPG SE DE++KI +I+GTPN+ TW G Sbjct: 196 MVNQKPLFPGDSEIDELFKIFSIMGTPNEETWPG 229
>CDC21_ORYSA (P29618) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 294 Score = 140 bits (354), Expect = 2e-33 Identities = 69/155 (44%), Positives = 104/155 (67%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGK-PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 ++ VFEY++ +L + M S + + T I+++ +Q+ + +++ H HRDLKP+NLL+ Sbjct: 76 IYLVFEYLDLDLKKFMDSCPEFAKNPTLIKSYLYQILRGVAYCHSHRVLHRDLKPQNLLI 135 Query: 223 TKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VDMW++G I A Sbjct: 136 DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRQYSTPVDMWSVGCIFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + +PLFPG SE DE++KI +LGTPN+ +W G Sbjct: 196 EMVNQKPLFPGDSEIDELFKIFRVLGTPNEQSWPG 230
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 140 bits (354), Expect = 2e-33 Identities = 71/157 (45%), Positives = 101/157 (64%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ VFE+++ +L + M+S +G I+ + Q+ + + H H HRDLKP Sbjct: 77 DSHKLYLVFEFLDLDLKKYMESIPQGVGLGANMIKRFMNQLIRGIKHCHSHRVLHRDLKP 136 Query: 208 ENLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ KE +K+ADFGLAR + YT V T WYRAPE+LL YS+ VDMW++G Sbjct: 137 QNLLIDKEGNLKLADFGLARAFGVPLRAYTHEVVTLWYRAPEILLGGKQYSTGVDMWSVG 196 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AE+ + +PLFPG SE DEI++I ILGTPN+ W Sbjct: 197 CIFAEMCNRKPLFPGDSEIDEIFRIFRILGTPNEEIW 233
>CDC22_MEDSA (Q05006) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 294 Score = 140 bits (353), Expect = 2e-33 Identities = 70/155 (45%), Positives = 101/155 (65%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGK-PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFEY++ +L + M S + + +I+ + +Q+ +++ H HRDLKP+NLL+ Sbjct: 76 LYLVFEYLDLDLKKFMDSSPEFAKDQRQIKMFLYQILCGIAYCHSHRVLHRDLKPQNLLI 135 Query: 223 TKE--LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G I A Sbjct: 136 DRSSNAVKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + RPLFPG SE DE++KI I GTPN+ TW G Sbjct: 196 EMINQRPLFPGDSEIDELFKIFRITGTPNEETWPG 230
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 140 bits (352), Expect = 3e-33 Identities = 73/166 (43%), Positives = 104/166 (62%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q M G S ++ + +Q+ + L++ H+R HRDLKP+NLL+ Sbjct: 263 LTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLIN 322 Query: 226 -KELIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 K +K+ADFGLAR + + Y+ V T WYR P+VLL SS YS+ +DMW +G I E+ Sbjct: 323 EKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEM 382 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 S RPLFPGS+ DE++ I +LGTP+Q TW G ++ FP Sbjct: 383 ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFP 428
>CDC2_VIGAC (Q41639) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 139 bits (351), Expect = 4e-33 Identities = 70/155 (45%), Positives = 102/155 (65%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSET-EIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFEY++ +L + M S + + +++ + +Q+ +++ H HRDLKP+NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSSPEFVKDPRQVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLI 135 Query: 223 TKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G I A Sbjct: 136 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + RPLFPG SE DE++KI ILGTPN+ TW G Sbjct: 196 EMVNRRPLFPGDSEIDELFKIFRILGTPNEETWPG 230
>CD2L1_MOUSE (P24788) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 784 Score = 139 bits (350), Expect = 5e-33 Identities = 72/161 (44%), Positives = 99/161 (61%), Gaps = 2/161 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 D ++ V Y+E +L LM++ +PF E++ Q+ + H+H HRDLK NLL Sbjct: 499 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLL 558 Query: 220 VTKE-LIKVADFGLAREIISE-PPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 ++ ++KV DFGLARE S YT V T WYRAPE+LL + YS+AVDMW++G I Sbjct: 559 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 618 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAA 516 EL + +PLFPG S+ D+I KI LGTP++ W G L A Sbjct: 619 ELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPA 659
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 139 bits (350), Expect = 5e-33 Identities = 72/166 (43%), Positives = 104/166 (62%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q M G S ++ + +Q+ + L++ H+R HRDLKP+NLL+ Sbjct: 263 LTLVFEYLDKDLKQYMDDCGSIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLIN 322 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + + Y+ V T WYR P+VLL SS YS+ +DMW +G I E+ Sbjct: 323 ERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEM 382 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 S RPLFPGS+ DE++ I +LGTP+Q TW G ++ FP Sbjct: 383 ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFP 428
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 139 bits (350), Expect = 5e-33 Identities = 72/166 (43%), Positives = 104/166 (62%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q M G S ++ + +Q+ + L++ H+R HRDLKP+NLL+ Sbjct: 263 LTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLIN 322 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + + Y+ V T WYR P+VLL SS YS+ +DMW +G I E+ Sbjct: 323 ERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEM 382 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 S RPLFPGS+ DE++ I +LGTP+Q TW G ++ FP Sbjct: 383 ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFP 428
>CD2L1_RAT (P46892) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 436 Score = 139 bits (350), Expect = 5e-33 Identities = 71/161 (44%), Positives = 99/161 (61%), Gaps = 2/161 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 D ++ V Y+E +L LM++ +PF E++ Q+ + H+H HRDLK NLL Sbjct: 151 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLL 210 Query: 220 VTKE-LIKVADFGLAREIISE-PPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 +T ++KV DFGLARE S YT V T WYRAPE+LL + YS+A DMW++G I Sbjct: 211 LTHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTACDMWSVGCIFG 270 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAA 516 EL + +PLFPG S+ D+I KI +GTP++ W G +L A Sbjct: 271 ELLTQKPLFPGKSDIDQINKIFKDIGTPSEKIWPGYSELPA 311
>CDC2_VIGUN (P52389) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 139 bits (349), Expect = 7e-33 Identities = 69/155 (44%), Positives = 102/155 (65%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSET-EIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFEY++ +L + M S + + +++ + +Q+ +++ H HRDLKP+NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSSPEFVKDPRQVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLI 135 Query: 223 TKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G + A Sbjct: 136 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCLFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + RPLFPG SE DE++KI ILGTPN+ TW G Sbjct: 196 EMVNRRPLFPGDSEIDELFKIFRILGTPNEETWPG 230
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 138 bits (348), Expect = 8e-33 Identities = 70/156 (44%), Positives = 104/156 (66%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETE--IRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L+ VFEY++ +L + M S + FS+ ++ + +Q+ + +++ H HRDLKP+NLL Sbjct: 76 LYLVFEYLDLDLKKHMDSCPE-FSQDPRLVKMFLYQILRGIAYCHSHRVLHRDLKPQNLL 134 Query: 220 VTKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 + + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G I Sbjct: 135 IDRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIF 194 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + RPLFPG SE DE++KI ++GTPN+ TW G Sbjct: 195 AEMVNQRPLFPGDSEIDELFKIFRVMGTPNEETWPG 230
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 138 bits (347), Expect = 1e-32 Identities = 68/155 (43%), Positives = 103/155 (66%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGK-PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 ++ VFEY++ +L + M S + + T I+++ +Q+ +++ H HRDLKP+NLL+ Sbjct: 76 IYLVFEYLDLDLKKFMDSCPEFAKNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLI 135 Query: 223 TKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + +K+ADFGLAR I +T V T WYRAPE+LL + YS+ VD+W++G I A Sbjct: 136 DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + +PLFPG SE DE++KI ILGTPN+ +W G Sbjct: 196 EMVNQKPLFPGDSEIDELFKIFRILGTPNEQSWPG 230
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 138 bits (347), Expect = 1e-32 Identities = 70/157 (44%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV- 222 L+ +FEY+ +L +LM K F+ I+++ Q+ A+ H HRDLKP+NLLV Sbjct: 80 LYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVD 139 Query: 223 TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 T IK+ADFGLAR + YT V T WYRAPE+LL + YS+ VD+W++G I +E+ Sbjct: 140 TAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 R LFPG SE D++Y+I L TP++ W G QL Sbjct: 200 IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQL 236
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 138 bits (347), Expect = 1e-32 Identities = 72/159 (45%), Positives = 100/159 (62%), Gaps = 4/159 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKP--FSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 + + LF +FE++ +L + M GK ++++ FQ+ QA+ HQR HRDLKP Sbjct: 90 QENRLFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCHQRRVIHRDLKP 149 Query: 208 ENLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLLV IK+ADFGLAR I I YT V T WYRAPE+L+ + YS VDMW++G Sbjct: 150 QNLLVDNNGAIKLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIG 209 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 I AE+ + +PLF G SE DE+++I +LGTP + W G Sbjct: 210 CIFAEMATKKPLFQGDSEIDELFRIFRVLGTPTELEWNG 248
>CDK10_HUMAN (Q15131) Cell division protein kinase 10 (EC 2.7.11.22)| (Serine/threonine-protein kinase PISSLRE) Length = 360 Score = 137 bits (346), Expect = 1e-32 Identities = 69/155 (44%), Positives = 101/155 (65%), Gaps = 2/155 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 + +F V Y E +L L+++ PFSE +++ QV + L ++H+ HRDLK NLL Sbjct: 111 ESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLL 170 Query: 220 VT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 +T K +K ADFGLAR + P T V T WYRAPE+LL ++ ++++DMWA+G I+A Sbjct: 171 MTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILA 230 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 EL +HRPL PG+SE +I I +LGTP+++ W G Sbjct: 231 ELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPG 265
>KP58_DROME (Q9VPC0) Serine/threonine-protein kinase PITSLRE (EC 2.7.11.22) (Cell| division cycle 2-like) Length = 952 Score = 137 bits (346), Expect = 1e-32 Identities = 75/164 (45%), Positives = 103/164 (62%), Gaps = 5/164 (3%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLM---KSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 D +F V +Y+E +L LM K++ + F E++ Q+ +A++H+H HRDLK Sbjct: 630 DKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTS 689 Query: 211 NLLVT-KELIKVADFGLAREIISE-PPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 NLL++ K ++KV DFGLARE S YT V T WYRAPE+LL S VYS+ +D+W++G Sbjct: 690 NLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGC 749 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAA 516 I AE PLFPG SE DE+ +I LGTPN+ W G +L A Sbjct: 750 IFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPA 793
>CDC2_CHERU (P93101) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 137 bits (344), Expect = 2e-32 Identities = 69/155 (44%), Positives = 101/155 (65%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFEY++ +L + M S + I+ + +Q+ + +++ H HRDLKP+NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSCPDFAKDPRMIKRFLYQILRGIAYCHSHRVLHRDLKPQNLLI 135 Query: 223 TKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 ++ +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G I A Sbjct: 136 DRQTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + +PLFPG SE DE++KI LGTPN+ TW G Sbjct: 196 EMVNQKPLFPGDSEIDELFKIFRTLGTPNEETWPG 230
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 136 bits (343), Expect = 3e-32 Identities = 73/160 (45%), Positives = 104/160 (65%), Gaps = 5/160 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETE---IRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE++ +L + M S P SE I+++ FQ+ Q +S H HRDLKP+NL Sbjct: 76 LYLVFEFLSQDLKKYMDST--PGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNL 133 Query: 217 LVTK-ELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ + IK+ADFGLAR + YT V T WYRAPE+LL S Y++AVD+W++G I Sbjct: 134 LINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIF 193 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 AE+ + + LFPG SE D++++I +LGTP++ TW G QL Sbjct: 194 AEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQL 233
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 136 bits (343), Expect = 3e-32 Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L +L+ + T +++ +Q+ + +S+ H HRDLKP+NLL+ Sbjct: 75 LTLVFEYLDQDLKKLLDACDGGLEPTTAKSFLYQILRGISYCHDHRILHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E ++K+ADFGLAR I YT V T WYRAP+VL+ S YS+AVD+W++G I AE+ Sbjct: 135 REGVLKLADFGLARAFAIPVRSYTHEVVTLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAA 516 + PLFPG SE D++ +I ILGTPN +W + L A Sbjct: 195 INGVPLFPGISEQDQLKRIFKILGTPNVDSWPQVVNLPA 233
>SPK1_SCHPO (P27638) Mitogen-activated protein kinase spk1 (EC 2.7.11.24) (MAP| kinase spk1) (MAPK) Length = 372 Score = 136 bits (342), Expect = 4e-32 Identities = 72/153 (47%), Positives = 101/153 (66%), Gaps = 5/153 (3%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 E + ++ V E ME +LY++++S+ P S+ + + +Q+ +AL MH G HRDLKP N Sbjct: 111 ELEDVYIVQELMETDLYRVIRSQ--PLSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSN 168 Query: 214 LLVTKEL-IKVADFGLAREIISE---PPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 LL+ +KVADFGLAR ++ P + TEYV+TRWYRAPE++L YS A+D+W+ Sbjct: 169 LLLNANCDLKVADFGLARSTTAQGGNPGFMTEYVATRWYRAPEIMLSFREYSKAIDLWST 228 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AE+ S RPLFPG +I I NILGTP Sbjct: 229 GCILAEMLSARPLFPGKDYHSQITLILNILGTP 261
>CDC2A_ARATH (P24100) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 135 bits (341), Expect = 6e-32 Identities = 70/156 (44%), Positives = 102/156 (65%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSET--EIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L+ VFEY++ +L + M S FS+ I+ + +Q+ + +++ H HRDLKP+NLL Sbjct: 76 LYLVFEYLDLDLKKHMDST-PDFSKDLHMIKTYLYQILRGIAYCHSHRVLHRDLKPQNLL 134 Query: 220 VTKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 + + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G I Sbjct: 135 IDRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSHHYSTPVDIWSVGCIF 194 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ S +PLFPG SE D+++KI I+GTP + TW G Sbjct: 195 AEMISQKPLFPGDSEIDQLFKIFRIMGTPYEDTWRG 230
>CDC2_SCHPO (P04551) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinse) Length = 297 Score = 135 bits (340), Expect = 7e-32 Identities = 69/157 (43%), Positives = 98/157 (62%), Gaps = 6/157 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLM----KSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 L+ VFE+++ +L + M ++ ++ + +Q+ ++ H R HRDLKP+N Sbjct: 80 LYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRIIHRDLKPQN 139 Query: 214 LLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 LL+ KE +K+ADFGLAR + YT + T WYRAPEVLL S YS+ VD+W++G I Sbjct: 140 LLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWSVGCI 199 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ PLFPG SE DEI+KI +LGTPN+ W G Sbjct: 200 FAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEEVWPG 236
>CDC21_MEDSA (P24923) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 291 Score = 135 bits (340), Expect = 7e-32 Identities = 69/155 (44%), Positives = 101/155 (65%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSET-EIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFEY++ +L + M S + + +++ + +Q+ +++ H HRDLKP+NLL+ Sbjct: 73 LYLVFEYLDLDLKKHMDSSPEFIKDPRQVKMFLYQMLCGIAYCHSHRVLHRDLKPQNLLI 132 Query: 223 TKEL--IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + +K+ADFGLAR I +T V T WYRAPE+LL S YS+ VD+W++G I A Sbjct: 133 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 192 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + RPL PG SE DE++KI ILGTPN+ TW G Sbjct: 193 EMANRRPLSPGDSEIDELFKIFRILGTPNEDTWPG 227
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 134 bits (338), Expect = 1e-31 Identities = 69/159 (43%), Positives = 103/159 (64%), Gaps = 2/159 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L +L+ + T +++ +Q+ + +S+ H HRDLKP+NLL+ Sbjct: 75 LTLVFEYLDQDLKKLLDACDGGLEPTTAKSFLYQILRGISYCHDHRILHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E ++K+ADFGLAR I YT V T WYRAP+VL+ S YS+AVD+W++G I AE+ Sbjct: 135 REGVLKLADFGLARAFAIPVRSYTHEVVTLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAA 516 + PLFPG SE D++ +I ILGTP+ +W + L A Sbjct: 195 INGVPLFPGISEQDQLKRIFKILGTPSVDSWPQVVNLPA 233
>CDC2_AJECA (P54119) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 324 Score = 134 bits (337), Expect = 2e-31 Identities = 71/173 (41%), Positives = 105/173 (60%), Gaps = 22/173 (12%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKS-------KGKPF-------------SETEIRNWCFQVFQALS 165 L+ VFE+++ +L + M++ +GK E ++ + Q+ + + Sbjct: 78 LYLVFEFLDLDLKKYMEALPVSEGGRGKALPDGSTLDMNRLGLGEAMVKKFMAQLVEGIR 137 Query: 166 HMHQRGYFHRDLKPENLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQ 339 + H HRDLKP+NLL+ +E +K+ADFGLAR + YT V T WYRAPE+LL Sbjct: 138 YCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLG 197 Query: 340 SSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 YS+ VDMW++GAI AE+ + +PLFPG SE DEI+KI +LGTP+++TW G Sbjct: 198 GRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKLLGTPDENTWPG 250
>CDC2B_ARATH (P25859) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) Length = 309 Score = 134 bits (336), Expect = 2e-31 Identities = 71/159 (44%), Positives = 98/159 (61%), Gaps = 8/159 (5%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKS--KG---KPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 L+ VFEY++ +L + + S KG KP I+ FQ+ + ++H H G HRDLKP+ Sbjct: 87 LYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLKPQ 146 Query: 211 NLLVTK--ELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 NLL+ K EL+K+AD GL R + YT + T WYRAPEVLL S+ YS+ VDMW++G Sbjct: 147 NLLLVKDKELLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVG 206 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 I AE+ + LFPG SE ++ I +LGTP + W G Sbjct: 207 CIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPG 245
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 134 bits (336), Expect = 2e-31 Identities = 63/143 (44%), Positives = 95/143 (66%), Gaps = 1/143 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFEY + L ++ S+ I++ +Q QAL+ H+ HRD+KPEN+L+T Sbjct: 76 MHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILIT 135 Query: 226 KE-LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 K+ +IK+ DFG AR +I YT+YV+TRWYRAPE+L+ + Y S+VD+WA+G + AEL Sbjct: 136 KQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELL 195 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 + +PL+PG S+ D++Y I LG Sbjct: 196 TGQPLWPGKSDVDQLYLIIRTLG 218
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 134 bits (336), Expect = 2e-31 Identities = 68/155 (43%), Positives = 104/155 (67%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKP--FSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L VFEYME +L + M + G ++++N+ Q+ + +S H+ HRDLKP+NLL Sbjct: 74 LMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNLL 133 Query: 220 V-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + ++ +K+ADFGLAR I I ++ V T WYRAP+VLL S VYS+++D+W++G I+A Sbjct: 134 INSRGELKLADFGLARSIGIPVNTFSNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMA 193 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + RPLF GS+ D++ KI +LGTP + +W G Sbjct: 194 EMATGRPLFAGSNNEDQLLKIFRLLGTPTEQSWPG 228
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 133 bits (335), Expect = 3e-31 Identities = 66/153 (43%), Positives = 100/153 (65%), Gaps = 4/153 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L+ +FE++ +L + + + G+ + ++++ +Q+ Q + H R HRDLKP+NLL Sbjct: 76 LYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSRRVLHRDLKPQNLL 135 Query: 220 VT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + K +IK+ADFGLAR I YT V T WYR+PEVLL S++YS+ VD+W++G I A Sbjct: 136 IDDKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSALYSTPVDIWSIGTIFA 195 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 EL + +PLF G SE D++++I LGTPN W Sbjct: 196 ELATKKPLFHGDSEIDQLFRIFRALGTPNNDVW 228
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 133 bits (334), Expect = 4e-31 Identities = 68/166 (40%), Positives = 102/166 (61%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G S ++ + FQ+ + L++ H R HRDLKP+NLL+ Sbjct: 213 LTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLIN 272 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + + Y+ V T WYR P+VLL S+ YS+ +DMW +G I E+ Sbjct: 273 ERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEM 332 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + RPLFPGS+ +E++ I +LGTP + TW G + + FP Sbjct: 333 ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFP 378
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 133 bits (334), Expect = 4e-31 Identities = 68/166 (40%), Positives = 102/166 (61%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G S ++ + FQ+ + L++ H R HRDLKP+NLL+ Sbjct: 213 LTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLIN 272 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + + Y+ V T WYR P+VLL S+ YS+ +DMW +G I E+ Sbjct: 273 ERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEM 332 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + RPLFPGS+ +E++ I +LGTP + TW G + + FP Sbjct: 333 ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFP 378
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 133 bits (334), Expect = 4e-31 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ ++ + + S G+ ++++ +Q+ Q + H RG HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDVKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRGVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K +IK+ADFGLAR I YT V T WYRAPEVLL S YS+ VD+W++G Sbjct: 132 QNLLIDNKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSVG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AE+ + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAEIATKKPLFHGDSEIDQLFRIFRSLGTPNNEVW 228
>CDC2B_ANTMA (Q38773) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 280 Score = 133 bits (334), Expect = 4e-31 Identities = 71/156 (45%), Positives = 102/156 (65%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSET--EIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L+ VFEY++ +L + M S + FS+ ++ + Q+ + +++ H HRDLKP+NLL Sbjct: 63 LYLVFEYLDLDLKKHMDSCPE-FSQDLHMVKMFLCQILRGVAYCHSHRVLHRDLKPQNLL 121 Query: 220 VTK--ELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 + + IK+ADFGLAR I +T V T WYRAPEVLL S YS+ VD+W++G I Sbjct: 122 IDRGSNTIKLADFGLARAFGIPVRTFTHEVVTLWYRAPEVLLGSRHYSTPVDVWSVGCIF 181 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + +PLFPG SE DE++KI I+GTPN+ W G Sbjct: 182 AEMVNQKPLFPGDSEIDELHKIFRIIGTPNEDIWPG 217
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 132 bits (333), Expect = 5e-31 Identities = 65/166 (39%), Positives = 105/166 (63%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G + ++ + FQ+ + L++ H+R HRDLKP+NLL+ Sbjct: 192 LTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHRRKILHRDLKPQNLLIN 251 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + + Y+ V T WYR P+VLL S+ YS+ +DMW +G I+ E+ Sbjct: 252 ERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEM 311 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + +PLFPGS+ +E++ I +LGTP + +W G ++ + FP Sbjct: 312 ATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFP 357
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 132 bits (332), Expect = 6e-31 Identities = 65/166 (39%), Positives = 104/166 (62%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G + ++ + FQ+ + L++ H R HRDLKP+NLL+ Sbjct: 192 LTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLIN 251 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + + Y+ V T WYR P+VLL S+ YS+ +DMW +G I+ E+ Sbjct: 252 ERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEM 311 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + +PLFPGS+ +E++ I +LGTP + +W G ++ + FP Sbjct: 312 ATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFP 357
>MKC1_CANAL (P43068) Mitogen-activated protein kinase MKC1 (EC 2.7.11.24) (MAP| kinase MKC1) Length = 501 Score = 132 bits (331), Expect = 8e-31 Identities = 66/158 (41%), Positives = 101/158 (63%), Gaps = 6/158 (3%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPEN 213 E + ++ E MEC+++Q+++S G+P S+ +++ +QV L+ +H HRDLKP N Sbjct: 121 EFNEIYLYEELMECDMHQIIRS-GQPLSDQHYQSFIYQVLCGLNFIHSADVLHRDLKPGN 179 Query: 214 LLVTKEL-IKVADFGLAREIISEPP-----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWA 375 LLV + +K+ DFGLAR P TEYV+TRWYRAPE++L + Y+ A+D+W+ Sbjct: 180 LLVNADCELKICDFGLARGFSENPDENAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWS 239 Query: 376 MGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHT 489 +G I+AEL +PLF G D++ +I ILGTP + T Sbjct: 240 VGCILAELLGGKPLFRGKDYVDQLNQILMILGTPPEST 277
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 132 bits (331), Expect = 8e-31 Identities = 70/156 (44%), Positives = 98/156 (62%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK---GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE++ +L + M + G P I+++ FQ+ Q L+ H HRDLKP+NL Sbjct: 76 LYLVFEFLHQDLKKFMDASALTGLPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 217 LVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + R LFPG SE D++++I LGTP++ W G Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 132 bits (331), Expect = 8e-31 Identities = 70/156 (44%), Positives = 98/156 (62%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK---GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE++ +L + M + G P I+++ FQ+ Q L+ H HRDLKP+NL Sbjct: 76 LYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 217 LVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I Sbjct: 134 LINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + R LFPG SE D++++I LGTP++ W G Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 132 bits (331), Expect = 8e-31 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ ++++ +Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPSGQYLEAMLVKSYLYQILQGIIFCHARRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ +K +IK+ADFGLAR I YT V T WYRAPEVLL S YS+ VD+W++G Sbjct: 132 QNLLIDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AE+ S +PLF G SE D++++I + GTPN W Sbjct: 192 TIFAEIASKKPLFHGDSEIDQLFRISELWGTPNNEVW 228
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 132 bits (331), Expect = 8e-31 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ ++++ +Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ +K +IK+ADFGLAR I YT V T WYRAPEVLL S YS+ VD+W++G Sbjct: 132 QNLLIDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AE+ + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228
>CDC2H_PLAVI (Q9XZD6) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (Pvcrk2) Length = 288 Score = 132 bits (331), Expect = 8e-31 Identities = 65/157 (41%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H+ HRDLKP+NLL+ Sbjct: 75 LILVFEHLDQDLKKLLDVCDGGLESVTAKSFLLQLLSGIAYCHEHRVLHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP++L+ S YS+ +DMW++G I AE+ Sbjct: 135 REGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDILMGSKKYSTPIDMWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 + RPLFPG SE D++ +I ILGTPN W +L Sbjct: 195 VNGRPLFPGVSETDQLMRIFRILGTPNSENWPNVTEL 231
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 131 bits (330), Expect = 1e-30 Identities = 66/154 (42%), Positives = 97/154 (62%), Gaps = 3/154 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKG-KPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFE++ +L + M S ++++ FQ+ Q L+ H HRDLKP+NLL+ Sbjct: 76 LYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI 135 Query: 223 TKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 + IK+ADFGLAR + +T V T WYRAPE+LL YS+AVD+W++G I AE Sbjct: 136 NSDGAIKLADFGLARAFGVPVRTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAE 195 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 + + R LFPG SE D++++I LGTP++ +W G Sbjct: 196 MITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPG 229
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 131 bits (330), Expect = 1e-30 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ + ++++ +Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKP 131 Query: 208 ENLLVT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K IK+ADFGLAR I YT V T WYR+PEVLL S+ YS+ VD+W++G Sbjct: 132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 131 bits (330), Expect = 1e-30 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ + ++++ +Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKP 131 Query: 208 ENLLVT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K IK+ADFGLAR I YT V T WYR+PEVLL S+ YS+ VD+W++G Sbjct: 132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 131 bits (330), Expect = 1e-30 Identities = 70/156 (44%), Positives = 98/156 (62%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK---GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE++ +L + M + G P I+++ FQ+ Q L+ H HRDLKP+NL Sbjct: 76 LYLVFEFLHQDLKKFMDASAVTGIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 217 LVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + R LFPG SE D++++I LGTP++ W G Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 131 bits (329), Expect = 1e-30 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ + ++++ +Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKP 131 Query: 208 ENLLVT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K IK+ADFGLAR I YT V T WYR+PEVLL S+ YS+ VD+W++G Sbjct: 132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 131 bits (329), Expect = 1e-30 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ + ++++ +Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKP 131 Query: 208 ENLLVT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K IK+ADFGLAR I YT V T WYR+PEVLL S+ YS+ VD+W++G Sbjct: 132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAGYSTPVDIWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 131 bits (329), Expect = 1e-30 Identities = 70/153 (45%), Positives = 99/153 (64%), Gaps = 4/153 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKG-KPFSETEIRNW-CFQVFQALSHMHQRGYFHRDLKPENLL 219 L VFEYM+ +L + M + G K ET+ W +Q+ + + H HRDLKP+NLL Sbjct: 78 LNLVFEYMDKDLKKFMDTNGNKGALETKQVKWFMYQLLRGILFCHDNRVLHRDLKPQNLL 137 Query: 220 VT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + K +K+ADFGLAR I ++ V T WYRAP+VLL S YS+++D+W+ G I+A Sbjct: 138 INAKGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDIWSAGCIMA 197 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 E+F+ RPLFPGSS D++ I ++GTPN+ TW Sbjct: 198 EMFTGRPLFPGSSNDDQLQHIFKLMGTPNESTW 230
>CDC2D_ANTMA (Q38775) Cell division control protein 2 homolog D (EC 2.7.11.22)| (EC 2.7.11.23) Length = 312 Score = 131 bits (329), Expect = 1e-30 Identities = 67/167 (40%), Positives = 104/167 (62%), Gaps = 6/167 (3%) Frame = +1 Query: 16 QGRS*XENDMLFFVFEYMECNLYQLMKS---KGKPFSETEIRNWCFQVFQALSHMHQRGY 186 QG++ +L+ VFEYM+ +L + ++S G+ + +++ +Q+ + ++ H G Sbjct: 82 QGQNKEGKTVLYLVFEYMDTDLKKYIRSFKQTGESIAPMNVKSLMYQLCKGVAFCHGHGV 141 Query: 187 FHRDLKPENLLVTKE--LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSS 357 HRDLKP NLL+ ++ ++K+AD GLAR + YT + T WYRAPEVLL ++ YS Sbjct: 142 LHRDLKPHNLLMDRKTMMLKIADLGLARAYTLPIKKYTHEILTLWYRAPEVLLGATHYSP 201 Query: 358 AVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AVDMW++ I AEL + + LFPG SE ++ I +LGTPN+ W G Sbjct: 202 AVDMWSVACIFAELVTQKALFPGDSELQQLLHIFRLLGTPNEEIWPG 248
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) Length = 379 Score = 130 bits (328), Expect = 2e-30 Identities = 65/153 (42%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+KS+ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 118 VYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN 175 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR I++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 176 TTCDLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 233 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 234 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 130 bits (328), Expect = 2e-30 Identities = 68/159 (42%), Positives = 98/159 (61%), Gaps = 4/159 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSK--GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 E + ++ +FE++ +L + M S K +R++ +Q+ A+ H+R HRDLKP Sbjct: 72 EENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKP 131 Query: 208 ENLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K LIKVADFGL R I YT + T WYRAPEVLL S YS VD+W++G Sbjct: 132 QNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 I AE+ + +PLF G SE D+++++ IL TP + W G Sbjct: 192 CIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPG 230
>ERK1_CANAL (P28869) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) (MAPK 1) Length = 417 Score = 130 bits (328), Expect = 2e-30 Identities = 63/154 (40%), Positives = 100/154 (64%), Gaps = 5/154 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ + E ME +L+++++++ S+ I+ + +Q +AL MH HRDLKP NLL+ Sbjct: 144 IYLIQELMETDLHRVIRTQN--LSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLN 201 Query: 226 KEL-IKVADFGLAREIISEPP----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 +K+ DFGLAR I S+ TEYV+TRWYRAPE++L Y++A+D+W++G I+ Sbjct: 202 SNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCIL 261 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 AE+ S RPLFPG ++++ I +LGTPN + Sbjct: 262 AEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDY 295
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 130 bits (328), Expect = 2e-30 Identities = 67/154 (43%), Positives = 97/154 (62%), Gaps = 3/154 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKP-FSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L+ VFE++ +L + M S S ++++ FQ+ Q L+ H HRDLKP+NLL+ Sbjct: 76 LYLVFEFLHQDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI 135 Query: 223 TKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 + IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I AE Sbjct: 136 NAQGEIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE 195 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 + + + LFPG SE D++++I LGTP++ W G Sbjct: 196 MITRKALFPGDSEIDQLFRIFRTLGTPDESIWPG 229
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 130 bits (328), Expect = 2e-30 Identities = 65/153 (42%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+KS+ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 119 VYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN 176 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR I++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 177 TTCDLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 234 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 235 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 267
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 130 bits (328), Expect = 2e-30 Identities = 65/153 (42%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+KS+ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 119 VYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN 176 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR I++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 177 TTCDLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 234 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 235 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 267
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 130 bits (328), Expect = 2e-30 Identities = 63/151 (41%), Positives = 96/151 (63%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H+ HRDLKP+NLL+ Sbjct: 75 LILVFEHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP++L+ S YS+ +D+W++G I AE+ Sbjct: 135 REGELKIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG+SE D++ +I ILGTPN W Sbjct: 195 VNGRPLFPGASETDQLMRIFKILGTPNSQNW 225
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 130 bits (327), Expect = 2e-30 Identities = 69/156 (44%), Positives = 98/156 (62%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK---GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE++ +L + M + G P I+++ FQ+ Q L+ H HRDLKP+NL Sbjct: 76 LYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 217 LVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ + IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I Sbjct: 134 LINADGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + R LFPG SE D++++I LGTP++ W G Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 130 bits (327), Expect = 2e-30 Identities = 67/157 (42%), Positives = 99/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 + L+ VFE++ +L + + S G+ ++++ +Q+ + + H R HRDLKP Sbjct: 72 QESKLYLVFEFLSMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K +IK+ADFGLAR + YT V T WYRAPEVLL +S YS+ VD+W++G Sbjct: 132 QNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYSTPVDVWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNEVW 228
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 130 bits (327), Expect = 2e-30 Identities = 66/157 (42%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H R HRDLKP+NLL+ Sbjct: 75 LVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP+VL+ S YS+ +D+W++G I AE+ Sbjct: 135 REGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 + PLFPG SEAD++ +I ILGTPN W +L Sbjct: 195 VNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTEL 231
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 130 bits (327), Expect = 2e-30 Identities = 66/157 (42%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H R HRDLKP+NLL+ Sbjct: 75 LVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP+VL+ S YS+ +D+W++G I AE+ Sbjct: 135 REGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 + PLFPG SEAD++ +I ILGTPN W +L Sbjct: 195 VNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTEL 231
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 130 bits (326), Expect = 3e-30 Identities = 66/157 (42%), Positives = 98/157 (62%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 + L+ +FE++ +L + + S G+ ++++ +Q+ + + H+R HRDLKP Sbjct: 72 QESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K +IK+ADFGLAR + YT V T WYRAPEVLL S YS+ VD+W+ G Sbjct: 132 QNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVW 228
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 130 bits (326), Expect = 3e-30 Identities = 66/157 (42%), Positives = 98/157 (62%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 + L+ +FE++ +L + + S G+ ++++ +Q+ + + H+R HRDLKP Sbjct: 72 QESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K +IK+ADFGLAR + YT V T WYRAPEVLL S YS+ VD+W+ G Sbjct: 132 QNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVW 228
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 130 bits (326), Expect = 3e-30 Identities = 66/157 (42%), Positives = 98/157 (62%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 + L+ +FE++ +L + + S G+ ++++ +Q+ + + H+R HRDLKP Sbjct: 72 QESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K +IK+ADFGLAR + YT V T WYRAPEVLL S YS+ VD+W+ G Sbjct: 132 QNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVW 228
>CDKL4_HUMAN (Q5MAI5) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 315 Score = 130 bits (326), Expect = 3e-30 Identities = 61/143 (42%), Positives = 94/143 (65%), Gaps = 1/143 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFEY + L ++ ++ I++ +Q QAL+ H HRD+KPEN+L+T Sbjct: 76 MHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILIT 135 Query: 226 KE-LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 K+ +IK+ DFG A+ +I YT+YV+TRWYRAPE+L+ + Y S+VD+WA+G + AEL Sbjct: 136 KQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELL 195 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 + +PL+PG S+ D++Y I LG Sbjct: 196 TGQPLWPGKSDVDQLYLIIRTLG 218
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 130 bits (326), Expect = 3e-30 Identities = 70/156 (44%), Positives = 97/156 (62%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK---GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE + +L + M + G P I+++ FQ+ Q L+ H HRDLKP+NL Sbjct: 76 LYLVFELLHQDLKKFMDASAVTGIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 217 LVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ + R LFPG SE D++++I LGTP++ W G Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 130 bits (326), Expect = 3e-30 Identities = 63/153 (41%), Positives = 97/153 (63%), Gaps = 4/153 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L+ VFE+++ +L + M+ K +P ++ + Q+ + +++ H HRDLKP+NLL Sbjct: 84 LYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLL 143 Query: 220 VTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + K+ +K+ DFGLAR + YT + T WYRAPEVLL YS+ VD W++G I A Sbjct: 144 INKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFA 203 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 E+ + +P+F G SE D+I+KI +LGTPN+ W Sbjct: 204 EMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIW 236
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 129 bits (325), Expect = 4e-30 Identities = 67/157 (42%), Positives = 100/157 (63%), Gaps = 2/157 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L+ VFEY++ +L + M S + I+++ +Q+ + L++ H HRDLKP+NLL+ Sbjct: 80 LYLVFEYLDQDLKKYMDSVPALCPQL-IKSYLYQLLKGLAYSHGHRILHRDLKPQNLLID 138 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 ++ +K+ADFGLAR + I YT + T WYRAPEVLL S YS VDMW++G I E+ Sbjct: 139 RQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEM 198 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 + +PLF G E D+I++I +LGTP+ W G +L Sbjct: 199 LNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKL 235
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 129 bits (325), Expect = 4e-30 Identities = 67/157 (42%), Positives = 99/157 (63%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 ++ L+ +FE++ +L + + S G+ + ++++ Q+ Q + H R HRDLKP Sbjct: 72 QDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKP 131 Query: 208 ENLLVT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K IK+ADFGLAR I YT V T WYR+PEVLL S+ YS+ VD+W++G Sbjct: 132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 129 bits (325), Expect = 4e-30 Identities = 66/166 (39%), Positives = 103/166 (62%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G + ++ + FQ+ + L++ H++ HRDLKP+NLL+ Sbjct: 236 LTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN 295 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + I Y+ V T WYR P++LL S+ YS+ +DMW +G I E+ Sbjct: 296 ERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEM 355 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + RPLFPGS+ ++++ I ILGTP + TW G L + +P Sbjct: 356 ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYP 401
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 129 bits (325), Expect = 4e-30 Identities = 64/151 (42%), Positives = 99/151 (65%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L + + G S+ I+++ +Q+ + ++ H HRDLKP+NLL+ Sbjct: 76 LTLVFEYLDQDLKKYLDECGGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 ++ +K+ADFGLAR I Y+ V T WYRAP+VL+ S YS+ +D+W+ I AE+ Sbjct: 136 RKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSALCIFAEM 195 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 S RPLFPGS +D++++I ILGTPN+ +W Sbjct: 196 ASGRPLFPGSGTSDQLFRIFKILGTPNEESW 226
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 129 bits (325), Expect = 4e-30 Identities = 63/151 (41%), Positives = 95/151 (62%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H+ HRDLKP+NLL+ Sbjct: 76 LILVFEHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP++L+ S YS+ +D+W++G I AE+ Sbjct: 136 REGELKIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEM 195 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG SE D++ +I ILGTPN W Sbjct: 196 VNGRPLFPGVSETDQLMRIFKILGTPNSQNW 226
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 129 bits (325), Expect = 4e-30 Identities = 64/157 (40%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H+ HRDLKP+NLL+ Sbjct: 75 LILVFEHLDQDLKKLLDVCDGGLESVTAKSFLLQLLSGIAYCHEHRVLHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP++L+ S YS+ +D+W++G I AE+ Sbjct: 135 REGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 + RPLFPG SE D++ +I ILGTPN W +L Sbjct: 195 VNGRPLFPGVSETDQLMRIFRILGTPNSANWPSVTEL 231
>CC2H2_TRYBB (P54665) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 345 Score = 129 bits (324), Expect = 5e-30 Identities = 64/154 (41%), Positives = 92/154 (59%), Gaps = 3/154 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L +FEYME +L ++K + F ++R FQ+ L H R + HRD+KP N+L+ Sbjct: 118 LLLIFEYMEQDLQGMLKQRNTAFVGGKLRRIMFQLLLGLHECHSRRFVHRDIKPSNILID 177 Query: 226 KE--LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 ++ ++K+ADFGL R + YT V T WYRAPEVLL Y AVD+W+MG + AE Sbjct: 178 RKESVVKLADFGLGRAFRVPLQTYTTEVMTLWYRAPEVLLGDKQYLPAVDVWSMGCVFAE 237 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 L R LF G + ++++ I +LGTP + TW G Sbjct: 238 LARRRSLFAGDTAINQLFSIFQLLGTPTEATWRG 271
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 129 bits (324), Expect = 5e-30 Identities = 66/166 (39%), Positives = 103/166 (62%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G + ++ + FQ+ + L++ H++ HRDLKP+NLL+ Sbjct: 236 LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN 295 Query: 226 KE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR + I Y+ V T WYR P++LL S+ YS+ +DMW +G I E+ Sbjct: 296 ERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEM 355 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + RPLFPGS+ ++++ I ILGTP + TW G L + +P Sbjct: 356 ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYP 401
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 129 bits (323), Expect = 7e-30 Identities = 65/157 (41%), Positives = 98/157 (62%), Gaps = 4/157 (2%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKS--KGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 + L+ +FE++ +L + + S G+ ++++ +Q+ + + H+R HRDLKP Sbjct: 72 QESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKP 131 Query: 208 ENLLV-TKELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 +NLL+ K +IK+ADFGL+R + YT V T WYRAPEVLL S YS+ VD+W+ G Sbjct: 132 QNLLIDNKGVIKLADFGLSRAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTG 191 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I AEL + +PLF G SE D++++I LGTPN W Sbjct: 192 TIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVW 228
>CDK6_MOUSE (Q64261) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) (CRK2) Length = 326 Score = 128 bits (322), Expect = 9e-30 Identities = 69/151 (45%), Positives = 97/151 (64%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L VFE+++ +L + +P TE I++ FQ+ + L +H HRDLKP+N+LV Sbjct: 94 LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 Query: 223 TKE-LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 T IK+ADFGLAR + T V T WYRAPEVLLQSS Y++ VD+W++G I AE+ Sbjct: 154 TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM 212 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 F +PLF GSS+ D++ KI +I+G P + W Sbjct: 213 FRRKPLFRGSSDVDQLGKILDIIGLPGEEDW 243
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 128 bits (322), Expect = 9e-30 Identities = 62/151 (41%), Positives = 95/151 (62%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+++ +L +L+ +++ Q+ +++ H+ HRDLKP+NLL+ Sbjct: 75 LILVFEHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLIN 134 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGLAR I YT V T WYRAP++L+ S YS+ +D+W++G I AE+ Sbjct: 135 REGELKIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG S+ D++ +I ILGTPN W Sbjct: 195 VNGRPLFPGVSDTDQLMRIFKILGTPNSQNW 225
>CDKL5_HUMAN (O76039) Cyclin-dependent kinase-like 5 (EC 2.7.11.22)| (Serine/threonine-protein kinase 9) Length = 1030 Score = 128 bits (321), Expect = 1e-29 Identities = 60/145 (41%), Positives = 98/145 (67%), Gaps = 3/145 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L+ VFEY+E N+ +L++ +++++ +Q+ +A+ H+ HRD+KPENLL++ Sbjct: 85 LYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS 144 Query: 226 -KELIKVADFGLAREII--SEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 +++K+ DFG AR + + YTEYV+TRWYR+PE+LL + Y +VDMW++G I+ E Sbjct: 145 HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPYGKSVDMWSVGCILGE 203 Query: 397 LFSHRPLFPGSSEADEIYKICNILG 471 L +PLFPG SE D+++ I +LG Sbjct: 204 LSDGQPLFPGESEIDQLFTIQKVLG 228
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 128 bits (321), Expect = 1e-29 Identities = 63/153 (41%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+K++ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 98 VYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 155 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR +++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 156 TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 213 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 214 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 246
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 128 bits (321), Expect = 1e-29 Identities = 63/153 (41%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+K++ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 98 VYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 155 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR +++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 156 TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 213 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 214 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 246
>CDK6_HUMAN (Q00534) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) Length = 326 Score = 128 bits (321), Expect = 1e-29 Identities = 68/151 (45%), Positives = 97/151 (64%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 L VFE+++ +L + +P TE I++ FQ+ + L +H HRDLKP+N+LV Sbjct: 94 LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 Query: 223 TKE-LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 T IK+ADFGLAR + T V T WYRAPEVLLQSS Y++ VD+W++G I AE+ Sbjct: 154 TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM 212 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 F +PLF GSS+ D++ KI +++G P + W Sbjct: 213 FRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243
>CDC2C_ANTMA (Q38774) Cell division control protein 2 homolog C (EC 2.7.11.22)| (EC 2.7.11.23) Length = 305 Score = 128 bits (321), Expect = 1e-29 Identities = 69/160 (43%), Positives = 100/160 (62%), Gaps = 8/160 (5%) Frame = +1 Query: 43 MLFFVFEYMECNLYQLMKSKGK-----PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKP 207 +L+ VFEY++ +L + + S K P +I+++ FQ+ + +SH H G HRDLKP Sbjct: 82 LLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPQQIQSFLFQLCKGVSHCHAHGVLHRDLKP 141 Query: 208 ENLLVTKE--LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 +NLL+ K+ ++K+AD GLAR + YT + T YRAPEVLL SS YS+AVDM ++ Sbjct: 142 QNLLLDKDKGVLKIADLGLARAFTVPLKSYTHEIVTLSYRAPEVLLGSSHYSTAVDMSSV 201 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 G I AE+ + LFPG SE ++ I +LGTP+ W G Sbjct: 202 GCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPSDEQWPG 241
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 128 bits (321), Expect = 1e-29 Identities = 63/153 (41%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+K++ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 100 VYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 157 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR +++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 158 TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 215 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 216 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 248
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 128 bits (321), Expect = 1e-29 Identities = 63/153 (41%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+K++ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 100 VYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 157 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR +++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 158 TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 215 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 216 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 248
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 128 bits (321), Expect = 1e-29 Identities = 63/153 (41%), Positives = 101/153 (66%), Gaps = 7/153 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +LY+L+K++ S I + +Q+ + L ++H HRDLKP NLL+ Sbjct: 104 VYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 161 Query: 226 KEL-IKVADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR +++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 162 TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 219 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 I+AE+ S+RP+FPG D++ I ILG+P+Q Sbjct: 220 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 252
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 127 bits (320), Expect = 1e-29 Identities = 67/162 (41%), Positives = 99/162 (61%), Gaps = 3/162 (1%) Frame = +1 Query: 34 ENDMLFFVFEYMECNLYQLMKSKGK-PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 E+ L+ VFE+ + +LYQ M K P +ET R+ +Q+ Q L+ H HRD+KP+ Sbjct: 72 EDKFLYLVFEFCDEDLYQFMSRSSKIPINET--RSIVYQILQGLAFCHYHQILHRDMKPQ 129 Query: 211 NLLVTKE-LIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 N+L+ K IK+ +FGLAR I++ YT V T WYRAPE+LL ++ Y A+D+W+ A Sbjct: 130 NILINKNGTIKLGEFGLARLTTINDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAA 189 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 I EL + LF G + D+++KI + LGTP + W G +L Sbjct: 190 IFGELINKEELFKGRCKIDQLFKIFSQLGTPTEDIWNGVTKL 231
>MPK5_ARATH (Q39025) Mitogen-activated protein kinase homolog 5 (EC 2.7.11.24)| (MAP kinase 5) (AtMPK5) Length = 376 Score = 127 bits (319), Expect = 2e-29 Identities = 59/146 (40%), Positives = 94/146 (64%), Gaps = 1/146 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ VFE M+ +L+Q+++S + ++ + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 120 VYIVFELMDTDLHQIIRSN-QSLNDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 178 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL SS Y+SA+D+W++G I AE+ Sbjct: 179 SNCDLKITDFGLARTTSETEYMTEYVVTRWYRAPELLLNSSEYTSAIDVWSVGCIFAEIM 238 Query: 403 SHRPLFPGSSEADEIYKICNILGTPN 480 + PLFPG ++ I ++G+P+ Sbjct: 239 TREPLFPGKDYVHQLKLITELIGSPD 264
>SLT2_YEAST (Q00772) Mitogen-activated protein kinase SLT2/MPK1 (EC 2.7.11.24)| (MAP kinase MPK1) Length = 484 Score = 127 bits (319), Expect = 2e-29 Identities = 61/154 (39%), Positives = 95/154 (61%), Gaps = 6/154 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L+ E MEC+++Q++KS G+P ++ +++ +Q+ L ++H HRDLKP NLLV Sbjct: 104 LYLYEELMECDMHQIIKS-GQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVN 162 Query: 226 KEL-IKVADFGLAREIISEPP-----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 + +K+ DFGLAR P TEYV+TRWYRAPE++L Y+ A+D+W+ G I Sbjct: 163 ADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCI 222 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPNQHT 489 +AE +P+F G +++ +I +LGTP T Sbjct: 223 LAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDET 256
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 127 bits (318), Expect = 3e-29 Identities = 66/155 (42%), Positives = 98/155 (63%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L+ +FEY++ +L + ++ +G F+ T ++ +Q+ + LS H+ HRDLKP N+LVT Sbjct: 95 LYLIFEYVDHDLKKALEKRGGAFTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVT 154 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR I YT V T WYRAPE+LL Y+ AVDMW++G I AEL Sbjct: 155 TDNSVKIADFGLARAFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSIGCIFAEL 214 Query: 400 FSHRPLFPGSSEADEIYKICNILGTP--NQHTWAG 498 + LF G SE ++++I +LGTP + +W G Sbjct: 215 ARGKVLFRGDSEIGQLFEIFQVLGTPMDAEGSWLG 249
>CDC2_EMENI (Q00646) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 323 Score = 127 bits (318), Expect = 3e-29 Identities = 67/172 (38%), Positives = 99/172 (57%), Gaps = 21/172 (12%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMK-------------------SKGKPFSETEIRNWCFQVFQALSH 168 L+ VFE+++ +L + M+ S+ + ++ + Q+ + + Sbjct: 78 LYLVFEFLDLDLKKYMEALPVSEGGRGRALPDGSTLSRNLGLGDAMVKKFMAQLIEGIRF 137 Query: 169 MHQRGYFHRDLKPENLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQS 342 H HRDLKP+NLL+ ++ +K+ADFGLAR + YT V T WYR+PE+LL Sbjct: 138 CHSHRVLHRDLKPQNLLIDRDGNLKLADFGLARAFGVPLRTYTHEVVTLWYRSPEILLGG 197 Query: 343 SVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 YS+ VDMW+ GAI AE+ + +PLFPG SE DEI+KI ILGTP++ W G Sbjct: 198 RQYSTGVDMWSCGAIFAEMCTRKPLFPGDSEIDEIFKIFRILGTPDETIWPG 249
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 126 bits (317), Expect = 3e-29 Identities = 62/146 (42%), Positives = 98/146 (67%), Gaps = 7/146 (4%) Frame = +1 Query: 67 MECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKEL-IKV 243 ME +LY+L+K++ S I + +Q+ + L ++H HRDLKP NLL+ K +K+ Sbjct: 121 METDLYKLLKTQR--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKI 178 Query: 244 ADFGLAREIISEPPY------TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 DFGLAR I++P + TEYV+TRWYRAPE++L S Y+ ++D+W++G I+AE+ S Sbjct: 179 CDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 236 Query: 406 HRPLFPGSSEADEIYKICNILGTPNQ 483 +RP+FPG D++ I +LG+P++ Sbjct: 237 NRPIFPGKHYLDQLNHILGVLGSPSR 262
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 126 bits (317), Expect = 3e-29 Identities = 65/166 (39%), Positives = 101/166 (60%), Gaps = 2/166 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L Q + G + ++ + FQ+ + L++ H++ HRDLKP+NLL+ Sbjct: 236 LTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN 295 Query: 226 KE-LIKVADFGLA-REIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLA + I Y+ V T WYR P++LL S+ YS +DMW +G I E+ Sbjct: 296 ERGELKLADFGLAYAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSGQIDMWGVGCIFYEM 355 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQFP 537 + RPLFPGS+ ++++ I ILGTP + TW G L + +P Sbjct: 356 ATGRPLFPGSTVEEQLHFIFRILGTPTEDTWPGILSNEEFRTYNYP 401
>YPC2_CAEEL (Q11179) Putative serine/threonine-protein kinase C05D10.2 in| chromosome III (EC 2.7.11.24) Length = 470 Score = 126 bits (317), Expect = 3e-29 Identities = 71/180 (39%), Positives = 108/180 (60%), Gaps = 12/180 (6%) Frame = +1 Query: 34 ENDM-LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 +ND ++ FE+ME +L+ ++K KG + + Q+F+A+ +H HRDLKP Sbjct: 83 DNDRDIYLAFEFMEADLHNVIK-KGSILKDVHKQYIMCQLFRAIRFLHSGNVLHRDLKPS 141 Query: 211 NLLVTKEL-IKVADFGLAREIIS---------EPPYTEYVSTRWYRAPEVLLQSSVYSSA 360 N+L+ + +K+ADFGLAR + S P TEYV+TRWYR+PE+LL + Y+ Sbjct: 142 NVLLDADCRVKLADFGLARSLSSLEDYPEGQKMPDLTEYVATRWYRSPEILLAAKRYTKG 201 Query: 361 VDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG-GLQLAASIHFQFP 537 VDMW++G I+AE+ R LFPGSS ++I +I N + P++ A G AAS+ + P Sbjct: 202 VDMWSLGCILAEMLIGRALFPGSSTINQIERIMNTIAKPSRADIASIGSHYAASVLEKMP 261
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 126 bits (316), Expect = 4e-29 Identities = 66/164 (40%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE- 231 VF++ME +L ++K + + I+ + Q L ++HQ HRDLKP NLL+ + Sbjct: 90 VFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG 149 Query: 232 LIKVADFGLAREIIS-EPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 ++K+ADFGLA+ S YT V TRWYRAPE+L + +Y VDMWA+G I+AEL Sbjct: 150 VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR 209 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQ-FP 537 P PG S+ D++ +I LGTP + W L + F+ FP Sbjct: 210 VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFP 253
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 126 bits (316), Expect = 4e-29 Identities = 66/164 (40%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE- 231 VF++ME +L ++K + + I+ + Q L ++HQ HRDLKP NLL+ + Sbjct: 90 VFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG 149 Query: 232 LIKVADFGLAREIIS-EPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 ++K+ADFGLA+ S YT V TRWYRAPE+L + +Y VDMWA+G I+AEL Sbjct: 150 VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR 209 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQ-FP 537 P PG S+ D++ +I LGTP + W L + F+ FP Sbjct: 210 VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFP 253
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 125 bits (315), Expect = 6e-29 Identities = 66/164 (40%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE- 231 VF++ME +L ++K + + I+ + Q L ++HQ HRDLKP NLL+ + Sbjct: 82 VFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG 141 Query: 232 LIKVADFGLAREIISEP-PYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 ++K+ADFGLA+ S YT V TRWYRAPE+L + +Y VDMWA+G I+AEL Sbjct: 142 VLKLADFGLAKSFGSPNWAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR 201 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQ-FP 537 P PG S+ D++ +I LGTP + W L + F+ FP Sbjct: 202 VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFP 245
>MPK6_ARATH (Q39026) Mitogen-activated protein kinase homolog 6 (EC 2.7.11.24)| (MAP kinase 6) (AtMPK6) Length = 395 Score = 125 bits (315), Expect = 6e-29 Identities = 58/147 (39%), Positives = 93/147 (63%), Gaps = 1/147 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ +E M+ +L+Q+++S + SE + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 140 VYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 198 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL SS Y++A+D+W++G I EL Sbjct: 199 ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQ 483 +PLFPG ++ + ++GTP++ Sbjct: 259 DRKPLFPGRDHVHQLRLLMELIGTPSE 285
>MMK1_MEDSA (Q07176) Mitogen-activated protein kinase homolog MMK1 (EC| 2.7.11.24) (MAP kinase MSK7) (MAP kinase ERK1) Length = 387 Score = 125 bits (314), Expect = 7e-29 Identities = 58/147 (39%), Positives = 93/147 (63%), Gaps = 1/147 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ +E M+ +L+Q+++S + SE + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 132 VYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 190 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL SS Y++A+D+W++G I EL Sbjct: 191 ANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 250 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQ 483 +PLFPG ++ + ++GTP++ Sbjct: 251 DRKPLFPGRDHVHQLRLLMELIGTPSE 277
>MAPK_PEA (Q06060) Mitogen-activated protein kinase homolog D5 (EC 2.7.11.24)| Length = 394 Score = 125 bits (314), Expect = 7e-29 Identities = 58/147 (39%), Positives = 93/147 (63%), Gaps = 1/147 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ +E M+ +L+Q+++S + SE + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 139 VYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 197 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL SS Y++A+D+W++G I EL Sbjct: 198 ANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 257 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQ 483 +PLFPG ++ + ++GTP++ Sbjct: 258 DRKPLFPGRDHVHQLRLLMELIGTPSE 284
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 125 bits (314), Expect = 7e-29 Identities = 63/155 (40%), Positives = 98/155 (63%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKP--FSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L VFEYM+ +L + M+ G+ ++++ FQ+ + + H HRDLKP+NLL Sbjct: 79 LTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDNRVLHRDLKPQNLL 138 Query: 220 VT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + K +K+ DFGLAR I ++ V T WYRAP+VLL S Y++++D+W+ G I A Sbjct: 139 INNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSAGCIFA 198 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + +PLFPG++ D++ KI ++GTPN+ TW G Sbjct: 199 EMCTGKPLFPGTANEDQLIKIFRLMGTPNERTWPG 233
>NTF4_TOBAC (Q40532) Mitogen-activated protein kinase homolog NTF4 (EC| 2.7.11.24) (P45) Length = 393 Score = 125 bits (313), Expect = 1e-28 Identities = 58/147 (39%), Positives = 93/147 (63%), Gaps = 1/147 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ +E M+ +L+Q+++S + SE + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 137 VYIAYELMDTDLHQIIRSN-QGLSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 195 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL SS Y++A+D+W++G I EL Sbjct: 196 ANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 255 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQ 483 +PLFPG ++ + ++GTP++ Sbjct: 256 DRKPLFPGRDHVHQLRLLMELIGTPSE 282
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 125 bits (313), Expect = 1e-28 Identities = 63/155 (40%), Positives = 98/155 (63%), Gaps = 4/155 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKP--FSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 L VFE+M+ +L + M++ G ++++ FQ+ + + H HRDLKP+NLL Sbjct: 79 LTLVFEFMDKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGIMFCHDNRVLHRDLKPQNLL 138 Query: 220 VT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + K +K+ DFGLAR I ++ V T WYRAP+VLL S Y++++D+W+ G I A Sbjct: 139 INNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTASIDIWSAGCIFA 198 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 E+ + +PLFPG+S D++ KI ++GTPN+ TW G Sbjct: 199 EMCTGKPLFPGTSNDDQLIKIFRLMGTPNERTWPG 233
>CDK7_XENLA (P20911) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 352 Score = 124 bits (311), Expect = 2e-28 Identities = 65/164 (39%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE- 231 VF++ME +L ++K + I+++ Q L ++H HRDLKP NLL+ + Sbjct: 96 VFDFMETDLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDENG 155 Query: 232 LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 ++K+ADFGLA+ S YT V TRWYR+PE+L + +Y VDMWA+G I+AEL Sbjct: 156 VLKLADFGLAKSFGSPNRIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLR 215 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQ-FP 537 P PG S+ D++ +I LGTP + W G L + F+ FP Sbjct: 216 VPFLPGDSDLDQLTRIFETLGTPTEEQWPGMSSLPDYVAFKSFP 259
>MPK3_ARATH (Q39023) Mitogen-activated protein kinase homolog 3 (EC 2.7.11.24)| (MAP kinase 3) (AtMPK3) Length = 370 Score = 123 bits (309), Expect = 3e-28 Identities = 59/142 (41%), Positives = 90/142 (63%), Gaps = 1/142 (0%) Frame = +1 Query: 61 EYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKEL-I 237 E M+ +L+Q+++S + SE + + +Q+ + L ++H HRDLKP NLL+ + Sbjct: 120 ELMDTDLHQIIRSN-QSLSEEHCQYFLYQLLRGLKYIHSANIIHRDLKPSNLLLNANCDL 178 Query: 238 KVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSHRPL 417 K+ DFGLAR TEYV TRWYRAPE+LL SS Y++A+D+W++G I EL + +PL Sbjct: 179 KICDFGLARPTSENDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMNRKPL 238 Query: 418 FPGSSEADEIYKICNILGTPNQ 483 FPG ++ + +LGTP + Sbjct: 239 FPGKDHVHQMRLLTELLGTPTE 260
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 123 bits (309), Expect = 3e-28 Identities = 65/156 (41%), Positives = 95/156 (60%), Gaps = 3/156 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 + L FVFEYM +L Q M +R + FQ+ + L+++H + HRDLKP+NLL Sbjct: 121 ETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL 180 Query: 220 VTK-ELIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 ++ +K+ADFGLAR + I Y+ V T WYR P+ LL ++ YSS +D+W G I Sbjct: 181 ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFI 240 Query: 394 ELFSHRPLFPG-SSEADEIYKICNILGTPNQHTWAG 498 E+F +PLFPG S+ +++ KI +LG P + TW G Sbjct: 241 EMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPG 276
>MK07_MOUSE (Q9WVS8) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase) Length = 806 Score = 123 bits (308), Expect = 4e-28 Identities = 59/151 (39%), Positives = 95/151 (62%), Gaps = 6/151 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +L+Q++ S +P + +R + +Q+ + L +MH HRDLKP NLLV Sbjct: 133 VYVVLDLMESDLHQIIHSS-QPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN 191 Query: 226 KEL-IKVADFGLAREIISEPP-----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 + +K+ DFG+AR + + P TEYV+TRWYRAPE++L Y+ A+D+W++G I Sbjct: 192 ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCI 251 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPN 480 E+ + R LFPG + ++ I +LGTP+ Sbjct: 252 FGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
>YP62_CAEEL (Q09437) Putative serine/threonine-protein kinase B0495.2 (EC| 2.7.11.1) Length = 719 Score = 123 bits (308), Expect = 4e-28 Identities = 67/163 (41%), Positives = 99/163 (60%), Gaps = 6/163 (3%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQL---MKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 D ++ E++E ++ L M + K FS E + Q+ + HMH+ HRDLK Sbjct: 429 DKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTS 488 Query: 211 NLLVT-KELIKVADFGLAREIISEP--PYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMG 381 NLL++ K ++K+ADFGLARE +P +T V T WYR+PE+LL + +YS+ VDMW++G Sbjct: 489 NLLMSHKGILKIADFGLAREY-GDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVG 547 Query: 382 AIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 I+AE +PLFPG E ++I KI +GTP + W G +L Sbjct: 548 CIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTEL 590
>GSK31_SCHPO (Q9URT9) Protein kinase gsk31 (EC 2.7.11.1)| Length = 381 Score = 123 bits (308), Expect = 4e-28 Identities = 57/152 (37%), Positives = 97/152 (63%), Gaps = 5/152 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMK---SKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L + EYM ++ M+ + K I+ + FQ+F+AL+++H G HRD+KP+NL Sbjct: 97 LCLLLEYMPETVFDDMRWYTRRRKSIPNLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNL 156 Query: 217 LVTKE--LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LV + ++K+ DFG A+ ++ P Y+ +R+YRAPE++ ++ Y++ +D+W+ +I Sbjct: 157 LVDYKTGILKLCDFGSAKVLVPSEPNVSYICSRYYRAPELVFGATHYTTKIDVWSAACVI 216 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQH 486 AELF RPLFPG S +++ +I +LGTP+ H Sbjct: 217 AELFIGRPLFPGDSSVEQLVEIIRVLGTPSYH 248
>MK07_HUMAN (Q13164) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase) Length = 815 Score = 123 bits (308), Expect = 4e-28 Identities = 59/151 (39%), Positives = 95/151 (62%), Gaps = 6/151 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V + ME +L+Q++ S +P + +R + +Q+ + L +MH HRDLKP NLLV Sbjct: 132 VYVVLDLMESDLHQIIHSS-QPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN 190 Query: 226 KEL-IKVADFGLAREIISEPP-----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 + +K+ DFG+AR + + P TEYV+TRWYRAPE++L Y+ A+D+W++G I Sbjct: 191 ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCI 250 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPN 480 E+ + R LFPG + ++ I +LGTP+ Sbjct: 251 FGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 281
>BUR1_EMENI (Q96VK3) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) (Pitalre-like kinase A) Length = 544 Score = 122 bits (307), Expect = 5e-28 Identities = 60/164 (36%), Positives = 97/164 (59%), Gaps = 13/164 (7%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ VF YME +L L+++ FSE +I+ + Q+ + L ++H HRD+K NLL++ Sbjct: 105 MYMVFPYMEHDLSGLLENPEVHFSEAQIKCYMIQLLEGLKYLHGNCILHRDMKAANLLIS 164 Query: 226 KE-LIKVADFGLAREIISEPP------------YTEYVSTRWYRAPEVLLQSSVYSSAVD 366 + ++++ADFGLAR PP YT V TRWYR PE+LLQ Y+SA+D Sbjct: 165 NQGILQIADFGLARPFDEAPPQPGKGAGEAKRDYTTLVVTRWYRPPELLLQLRRYTSAID 224 Query: 367 MWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 MW +G + E+F +P+ G+S+ ++ I +++GTP + G Sbjct: 225 MWGVGCVFGEMFKGKPILAGNSDLNQAQLIFSLVGTPTEENMPG 268
>CCRK_PONPY (Q5R7I7) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 122 bits (307), Expect = 5e-28 Identities = 57/148 (38%), Positives = 92/148 (62%), Gaps = 3/148 (2%) Frame = +1 Query: 58 FEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE-L 234 FE+M +L ++++ +P ++ +++++ + + +S H HRDLKP NLL++ Sbjct: 81 FEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVSFCHANNIVHRDLKPANLLISASGQ 140 Query: 235 IKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + YT V+TRWYRAPE+L + Y VD+WA+G I+ EL + Sbjct: 141 LKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNG 200 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTW 492 PLFPG ++ +++ + ILGTPN W Sbjct: 201 SPLFPGKNDIEQLCYVLRILGTPNPQVW 228
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 122 bits (306), Expect = 6e-28 Identities = 67/157 (42%), Positives = 96/157 (61%), Gaps = 4/157 (2%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 + L VFEY+ +L Q M+ ++ + FQ+ + LS++HQR HRDLKP+NLL Sbjct: 204 ETLTLVFEYVHTDLCQYMEQHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLL 263 Query: 220 V--TKELIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 + T EL K+ADFGLAR + + Y+ V T WYR P+VLL S+ YS+ +DMW +G I Sbjct: 264 ISDTGEL-KLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIF 322 Query: 391 AELFSHRPLFPGSSE-ADEIYKICNILGTPNQHTWAG 498 E+ FPG + D++ +I +LGTPN+ TW G Sbjct: 323 VEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPG 359
>MMK2_MEDSA (Q40353) Mitogen-activated protein kinase homolog MMK2 (EC| 2.7.11.24) Length = 371 Score = 122 bits (306), Expect = 6e-28 Identities = 56/146 (38%), Positives = 94/146 (64%), Gaps = 1/146 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V E M+ +L+Q+++S +P ++ R + +Q+ + L ++H HRDLKP NLL+ Sbjct: 114 VYIVSELMDTDLHQIIRSN-QPMTDDHCRYFVYQLLRGLKYVHSANVLHRDLKPSNLLLN 172 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL S Y++A+D+W++G I+ E+ Sbjct: 173 ANCDLKIGDFGLARTTSETDFMTEYVVTRWYRAPELLLNCSDYTAAIDIWSVGCILGEIV 232 Query: 403 SHRPLFPGSSEADEIYKICNILGTPN 480 + +PLFPG ++ + ++G+P+ Sbjct: 233 TRQPLFPGRDYVHQLRLVTELIGSPD 258
>MPK4_ARATH (Q39024) Mitogen-activated protein kinase homolog 4 (EC 2.7.11.24)| (MAP kinase 4) (AtMPK4) Length = 376 Score = 122 bits (306), Expect = 6e-28 Identities = 57/146 (39%), Positives = 93/146 (63%), Gaps = 1/146 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q+++S +P ++ R + +Q+ + L ++H HRDLKP NLL+ Sbjct: 120 VYIVYELMDTDLHQIIRSN-QPLTDDHCRFFLYQLLRGLKYVHSANVLHRDLKPSNLLLN 178 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL S Y++A+D+W++G I+ E Sbjct: 179 ANCDLKLGDFGLARTKSETDFMTEYVVTRWYRAPELLLNCSEYTAAIDIWSVGCILGETM 238 Query: 403 SHRPLFPGSSEADEIYKICNILGTPN 480 + PLFPG ++ I ++G+P+ Sbjct: 239 TREPLFPGKDYVHQLRLITELIGSPD 264
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 122 bits (306), Expect = 6e-28 Identities = 65/165 (39%), Positives = 95/165 (57%), Gaps = 2/165 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ME +L +++ + S + +++ + + L+ H++ HRD+KP NLL+ Sbjct: 91 LHLVFEFMETDLEAVIRDRNIVLSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIG 150 Query: 226 KE-LIKVADFGLAREIIS-EPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR S E +T V RWYRAPE+L + Y SAVD+WA G I AEL Sbjct: 151 ADGQLKLADFGLARIFGSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAEL 210 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQF 534 RP GSS+ D++ KI GTP W + L + +QF Sbjct: 211 LLRRPFLQGSSDIDQLGKIFAAFGTPKSSQWPDMVYLPDYVEYQF 255
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 122 bits (306), Expect = 6e-28 Identities = 62/158 (39%), Positives = 101/158 (63%), Gaps = 7/158 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKG-----KPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 L VFEYM+ +L + M S+ + ++ + +Q+ + L+ H+ HRDLKP+ Sbjct: 77 LTLVFEYMDNDLKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHENKILHRDLKPQ 136 Query: 211 NLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 NLL+TK +K+ DFGLAR I ++ V T WYRAP+VL+ S YS+++D+W+ G Sbjct: 137 NLLITKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGC 196 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 I+AE+ + +PLFPG+++ +++ I + +GTPN+ TW G Sbjct: 197 ILAEMITGKPLFPGTNDEEQLKLIFDKMGTPNETTWPG 234
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 121 bits (304), Expect = 1e-27 Identities = 67/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 + L VFEY+ +L Q M ++ + FQ+ + LS++HQR HRDLKP+NLL Sbjct: 204 ETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLL 263 Query: 220 V--TKELIKVADFGLAR-EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 + T EL K+ADFGLAR + + Y+ V T WYR P+VLL S+ YS+ +DMW +G I Sbjct: 264 ISDTGEL-KLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIF 322 Query: 391 AELFSHRPLFPGSSE-ADEIYKICNILGTPNQHTWAG 498 E+ FPG + D++ +I +LGTPN+ TW G Sbjct: 323 VEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPG 359
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 121 bits (303), Expect = 1e-27 Identities = 60/152 (39%), Positives = 98/152 (64%), Gaps = 7/152 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V ME +LY+L+K++ S + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 172 IYIVQCLMETDLYKLLKTQ--KLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 229 Query: 226 KEL-IKVADFGLAREIISEPP------YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 +K+ DFGLAR +++P TEYV+TRWYRAPE++L S Y+ ++D+W++G Sbjct: 230 TTCDLKICDFGLAR--VTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGC 287 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPN 480 I+AE+ S+RPLFPG D++ I ++G+P+ Sbjct: 288 ILAEMLSNRPLFPGKHYLDQLNLILAVVGSPS 319
>CDK9_SCHPO (Q96WV9) Serine/threonine-protein kinase cdk9 (EC 2.7.11.1)| (Cyclin-dependent kinase cdk9) Length = 591 Score = 120 bits (302), Expect = 2e-27 Identities = 64/163 (39%), Positives = 99/163 (60%), Gaps = 15/163 (9%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V YM+ +L L+++ F+E +I+ + Q+F ++H + HRDLK NLL+ Sbjct: 116 IYMVTPYMDHDLSGLLENPSVKFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLID 175 Query: 226 KE-LIKVADFGLAREIISE----------PP----YTEYVSTRWYRAPEVLLQSSVYSSA 360 ++K+ADFGLAR I E PP YT V TRWYR+PE+LL Y++A Sbjct: 176 NHGILKIADFGLARVITEESYANKNPGLPPPNRREYTGCVVTRWYRSPELLLGERRYTTA 235 Query: 361 VDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHT 489 +DMW++G I+AE++ RP+ GSS+ D++ KI + G+P Q T Sbjct: 236 IDMWSVGCIMAEMYKGRPILQGSSDLDQLDKIFRLCGSPTQAT 278
>ERK1_DICDI (P42525) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) Length = 415 Score = 120 bits (302), Expect = 2e-27 Identities = 59/149 (39%), Positives = 95/149 (63%), Gaps = 3/149 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V E M+ +L+Q++ S +P S+ + + +Q+ + L H+H HRDLKP NLL+ Sbjct: 108 VYIVSELMDTDLHQIITSP-QPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLIN 166 Query: 226 KE-LIKVADFGLAR--EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 ++ L+K+ D GLAR + + TEYV+TRWYRAPEV+L + Y+ A+D+W++G I AE Sbjct: 167 EDCLLKICDLGLARVEDATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAE 226 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPNQ 483 L +PLF G +I I +G+P++ Sbjct: 227 LLGRKPLFQGKDYIHQITLIIETIGSPSE 255
>MAPK_FUSSO (Q00859) Mitogen-activated protein kinase (EC 2.7.11.24) (FsMAPK)| Length = 355 Score = 120 bits (302), Expect = 2e-27 Identities = 60/156 (38%), Positives = 95/156 (60%), Gaps = 5/156 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ + E ME ++++ ++++ S+ + + +Q +AL MH HRDLKP NLL+ Sbjct: 99 VYLIQELMETDMHRAIRTQD--LSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLN 156 Query: 226 KEL-IKVADFGLAREIISEPP----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 +KV DFGLAR S+ TEYV+TRWYRAPE++L Y+ A+D+W++G I+ Sbjct: 157 ANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCIL 216 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 AE+ S +PLFPG ++ I ++LGTP + G Sbjct: 217 AEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYG 252
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 120 bits (302), Expect = 2e-27 Identities = 64/154 (41%), Positives = 93/154 (60%), Gaps = 3/154 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ + +L + S R++ Q+ + L+ H HRDLKP+NLL+ Sbjct: 76 LTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 K +K+ADFGLAR I Y+ V T WYR P+VL + +Y++++DMW+ G I+AEL Sbjct: 136 KNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL 195 Query: 400 F-SHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 + RPLFPGS D++ KI +LGTPN+ +W G Sbjct: 196 ADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPG 229
>NTF6_TOBAC (Q40531) Mitogen-activated protein kinase homolog NTF6 (EC| 2.7.11.24) (P43) Length = 371 Score = 120 bits (301), Expect = 2e-27 Identities = 57/145 (39%), Positives = 92/145 (63%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q+++S + ++ + + +Q+ + L ++H HRDLKP NLL+ Sbjct: 115 VYIVYELMDTDLHQIIRSS-QALTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLN 173 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 +K+ DFGLAR TEYV TRWYRAPE+LL + Y++A+D+W++G I+ EL Sbjct: 174 ANCDLKICDFGLARTTSEADFMTEYVVTRWYRAPELLLNCTEYTAAIDIWSVGCILMELI 233 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 PLFPG A ++ I +LG+P Sbjct: 234 KREPLFPGRDYAQQLGLIIALLGSP 258
>CCRK_HUMAN (Q8IZL9) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) Length = 346 Score = 120 bits (301), Expect = 2e-27 Identities = 55/148 (37%), Positives = 92/148 (62%), Gaps = 3/148 (2%) Frame = +1 Query: 58 FEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE-L 234 FE+M +L ++++ +P ++ +++++ + + ++ H HRDLKP NLL++ Sbjct: 81 FEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQ 140 Query: 235 IKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + YT V+TRWYRAPE+L + Y VD+W++G I+ EL + Sbjct: 141 LKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNG 200 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTW 492 PLFPG ++ +++ + ILGTPN W Sbjct: 201 SPLFPGKNDIEQLCYVLRILGTPNPQVW 228
>SPM1_SCHPO (Q92398) Mitogen-activated protein kinase spm1 (EC 2.7.11.24) (MAP| kinase spm1) (MAP kinase pmk1) Length = 422 Score = 120 bits (300), Expect = 3e-27 Identities = 61/149 (40%), Positives = 90/149 (60%), Gaps = 6/149 (4%) Frame = +1 Query: 61 EYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKEL-I 237 E ME +L ++KS G+P ++ +++ +Q+ L ++H HRDLKP NLLV + + Sbjct: 105 ELMEADLNAIIKS-GQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCEL 163 Query: 238 KVADFGLAREIISEPP-----YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 K+ DFGLAR P TEYV+TRWYRAPE++L S Y +D+W++G I+AEL Sbjct: 164 KICDFGLARGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELL 223 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQHT 489 PLF G ++ I + LGTP++ T Sbjct: 224 GGTPLFKGKDFVHQLNLILHQLGTPDEET 252
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 119 bits (299), Expect = 4e-27 Identities = 61/145 (42%), Positives = 92/145 (63%), Gaps = 3/145 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY + + + + E ++N +Q QA++ H+ HRD+KPEN+L+T Sbjct: 76 LHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILIT 135 Query: 226 KE-LIKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 K+ IK+ DFG AR +++ P YT+YV+TRWYR+PE+L+ + Y VD+WA+G + AE Sbjct: 136 KQSAIKLCDFGFAR-LLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAE 194 Query: 397 LFSHRPLFPGSSEADEIYKICNILG 471 L S PL+PG S+ D++Y I LG Sbjct: 195 LLSGVPLWPGKSDVDQLYLIRKTLG 219
>NTF3_TOBAC (Q40517) Mitogen-activated protein kinase homolog NTF3 (EC| 2.7.11.24) (P43) Length = 372 Score = 119 bits (299), Expect = 4e-27 Identities = 59/148 (39%), Positives = 94/148 (63%), Gaps = 2/148 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q++KS + S + + FQ+ + L ++H HRDLKP NLL+ Sbjct: 109 VYLVYELMDTDLHQIIKSS-QTLSNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLIN 167 Query: 226 KEL-IKVADFGLAREIISEPPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +K+ DFGLAR + + TEYV TRWYRAPE+LL Y +++D+W++G I AEL Sbjct: 168 ANCDLKICDFGLARTSSGKDQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEL 227 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQ 483 +P+FPG+ +++ I NILG+ + Sbjct: 228 LGRKPVFPGTECLNQLKLIINILGSQRE 255
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 119 bits (299), Expect = 4e-27 Identities = 62/151 (41%), Positives = 89/151 (58%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEYME +L + M I+ + + + + H+R HRDLKP NLL++ Sbjct: 77 LNLVFEYMEMDLKKYMDRASGNLDPATIQEFMRSLLKGVRFCHERNVLHRDLKPPNLLIS 136 Query: 226 KEL-IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGL R I YT V T WYR+P+VLL S+ Y + VD+W++G I AE+ Sbjct: 137 REKELKLADFGLGRAFGIPVKKYTHEVVTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEM 196 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 PLF G ++AD++ +I LGTP+ W Sbjct: 197 AIGAPLFAGKNDADQLLRIFRFLGTPSSQVW 227
>MPK2_ARATH (Q39022) Mitogen-activated protein kinase homolog 2 (EC 2.7.11.24)| (MAP kinase 2) (AtMPK2) Length = 376 Score = 119 bits (299), Expect = 4e-27 Identities = 61/148 (41%), Positives = 95/148 (64%), Gaps = 2/148 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q++KS + S + + FQ+ + L ++H HRDLKP NLLV Sbjct: 109 VYLVYELMDTDLHQIIKSS-QVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVN 167 Query: 226 KEL-IKVADFGLAREIISEPPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +K+ DFGLAR ++ + TEYV TRWYRAPE+LL Y +++D+W++G I AEL Sbjct: 168 ANCDLKICDFGLARTSNTKGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEL 227 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQ 483 +P+FPG+ ++I I NILG+ + Sbjct: 228 LGRKPVFPGTECLNQIKLIINILGSQRE 255
>CRK1_SCHPO (Q12126) Serine/threonine-protein kinase crk1 (EC 2.7.11.23)| (Mitotic catastrophe suppressor 6) Length = 335 Score = 119 bits (299), Expect = 4e-27 Identities = 57/145 (39%), Positives = 86/145 (59%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L + E+++ +L L+K K F I++W + + L H+H R HRDLKP NLL++ Sbjct: 83 LNIILEFLDSDLEMLIKDKFIVFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLIS 142 Query: 226 KE-LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + ++K+ADFGL+R+ + + V TRWYR PE+ + Y + VDMW++G I AEL Sbjct: 143 SDGVLKLADFGLSRDFGTPSHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELM 202 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 P PG S+ D++ I LGTP Sbjct: 203 LRTPYLPGESDLDQLNVIFRALGTP 227
>MDS1_YEAST (P38615) Serine/threonine-protein kinase MDS1/RIM11 (EC 2.7.11.1)| Length = 370 Score = 119 bits (299), Expect = 4e-27 Identities = 58/152 (38%), Positives = 99/152 (65%), Gaps = 6/152 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKS---KGKPFSETEIRNWCFQVFQALSHMHQ-RGYFHRDLKPEN 213 L + EYM +LYQ ++ + P S EI+ + FQ+F++L+++H HRD+KP+N Sbjct: 110 LNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQN 169 Query: 214 LLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 LLV E +K+ DFG A+++ P Y+ +R+YRAPE++ ++ Y++ +D+W+ G + Sbjct: 170 LLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCV 229 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 +AEL +P+FPG S D++ +I ILGTP++ Sbjct: 230 MAELLLGQPMFPGESGIDQLVEIIKILGTPSK 261
>BUR1_ASPFU (Q4WTN5) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 580 Score = 119 bits (299), Expect = 4e-27 Identities = 59/164 (35%), Positives = 95/164 (57%), Gaps = 13/164 (7%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V YME +L L+++ F+E +I+ + Q+ + L ++H HRD+K NLL++ Sbjct: 105 MYMVTPYMEHDLSGLLENPAVNFTEPQIKCYMLQLLEGLKYLHGNRILHRDMKAANLLIS 164 Query: 226 KE-LIKVADFGLAREIISEPP------------YTEYVSTRWYRAPEVLLQSSVYSSAVD 366 ++++ADFGLAR PP YT V TRWYR PE+LLQ Y++A+D Sbjct: 165 NNGVLQIADFGLARPYDEPPPEPGKGGGEAKRDYTTLVVTRWYRPPELLLQLRRYTTAID 224 Query: 367 MWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 MW +G + E+F +P+ GSS+ ++ I N++GTP + G Sbjct: 225 MWGVGCVFGEMFKGKPILAGSSDLNQTQLIFNLVGTPTEENMPG 268
>CDK7_CARAU (P51953) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 344 Score = 119 bits (298), Expect = 5e-27 Identities = 65/161 (40%), Positives = 91/161 (56%), Gaps = 3/161 (1%) Frame = +1 Query: 64 YMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE-LIK 240 +ME +L ++K + I+ + Q L +MH HRDLKP NLL+ + ++K Sbjct: 92 FMETDLEVIIKDTSLVLTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLK 151 Query: 241 VADFGLAREIIS-EPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSHRPL 417 +ADFGLA+ S YT V TRWYRAPE+L + +Y VDMWA+G+I+AEL P Sbjct: 152 LADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPF 211 Query: 418 FPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHFQ-FP 537 G S+ D++ I LGTP + TW G L + F+ FP Sbjct: 212 LAGDSDLDQLTGIFEALGTPTEETWPGMSNLPDYVSFKLFP 252
>CDK4_RAT (P35426) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 119 bits (298), Expect = 5e-27 Identities = 66/148 (44%), Positives = 92/148 (62%), Gaps = 2/148 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE 231 VFE+++ +L + P E I++ Q L +H HRDLKPEN+LVT Sbjct: 92 VFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSN 151 Query: 232 -LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + T V T WYRAPEVLLQS+ Y++ VDMW++G I AE+F Sbjct: 152 GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRR 210 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTW 492 +PLF G+SEAD++ KI +++G P + W Sbjct: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDW 238
>CDK4_PIG (P79432) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 303 Score = 119 bits (298), Expect = 5e-27 Identities = 67/154 (43%), Positives = 95/154 (61%), Gaps = 2/154 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE 231 VFE+++ +L + P E I++ Q + L +H HRDLKPEN+LVT Sbjct: 92 VFEHVDQDLRTYLDKAPPPGLPVETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG 151 Query: 232 -LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + T V T WYRAPEVLLQS+ Y++ VDMW++G I AE+F Sbjct: 152 GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRR 210 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 +PLF G+SEAD++ KI +++G P + W + L Sbjct: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244
>CDK4_MOUSE (P30285) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) (CRK3) Length = 303 Score = 119 bits (298), Expect = 5e-27 Identities = 66/148 (44%), Positives = 92/148 (62%), Gaps = 2/148 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE 231 VFE+++ +L + P E I++ Q L +H HRDLKPEN+LVT Sbjct: 92 VFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSN 151 Query: 232 -LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + T V T WYRAPEVLLQS+ Y++ VDMW++G I AE+F Sbjct: 152 GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRR 210 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTW 492 +PLF G+SEAD++ KI +++G P + W Sbjct: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDW 238
>CDK4_HUMAN (P11802) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 119 bits (298), Expect = 5e-27 Identities = 67/154 (43%), Positives = 95/154 (61%), Gaps = 2/154 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE 231 VFE+++ +L + P E I++ Q + L +H HRDLKPEN+LVT Sbjct: 92 VFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG 151 Query: 232 -LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + T V T WYRAPEVLLQS+ Y++ VDMW++G I AE+F Sbjct: 152 GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRR 210 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 +PLF G+SEAD++ KI +++G P + W + L Sbjct: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 119 bits (298), Expect = 5e-27 Identities = 62/151 (41%), Positives = 90/151 (59%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE ME +L + M G I+ + + + H+R HRDLKP NLL++ Sbjct: 77 LTLVFECMEMDLKKYMDHVGGDLDAGTIQEFMRSLLSGVRFCHERNVLHRDLKPPNLLIS 136 Query: 226 KEL-IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ADFGL R I +T+ V T WYR+P+VLL S+ Y + VD+W++G I AE+ Sbjct: 137 REKELKLADFGLGRAFGIPVKKFTQEVVTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEM 196 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 PLF G ++AD++ +I LGTPN+ W Sbjct: 197 AIGAPLFTGKNDADQLLRIFQFLGTPNRQVW 227
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 119 bits (298), Expect = 5e-27 Identities = 57/145 (39%), Positives = 92/145 (63%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E +L++L+ S+ P + I+ + +Q+ + L ++H G HRDLKP N+L+ Sbjct: 96 IYFVNELQGTDLHRLLNSR--PLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILIN 153 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR + +P T YVSTR+YRAPE++L Y + VD+W++G I+AE+ Sbjct: 154 ENCDLKICDFGLAR--LQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMI 211 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG + I +LG+P Sbjct: 212 EGKPLFPGKDHVHQFSIITELLGSP 236
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 119 bits (298), Expect = 5e-27 Identities = 55/143 (38%), Positives = 87/143 (60%), Gaps = 2/143 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFE+++ + ++ ++ + FQ+ + H HRD+KPEN+LV+K Sbjct: 77 YLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSK 136 Query: 229 E-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++K+ DFG AR + + YT+YV+TRWYRAPE+L+ Y AVD+WA+G ++ E+F Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF 196 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 PLFPG S+ D++Y I LG Sbjct: 197 MGEPLFPGDSDIDQLYHIMMCLG 219
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 119 bits (297), Expect = 7e-27 Identities = 61/145 (42%), Positives = 91/145 (62%), Gaps = 3/145 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY + + + E ++N +Q QA++ H+ HRD+KPEN+L+T Sbjct: 76 LHLVFEYCHHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILIT 135 Query: 226 KE-LIKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 K +IK+ DFG AR +++ P YT+YV+TRWYR+PE+L+ + Y VD+WA+G + AE Sbjct: 136 KHSVIKLCDFGFAR-LLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAE 194 Query: 397 LFSHRPLFPGSSEADEIYKICNILG 471 L S PL+PG S+ D++Y I LG Sbjct: 195 LLSGVPLWPGKSDVDQLYLIRKTLG 219
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 119 bits (297), Expect = 7e-27 Identities = 57/145 (39%), Positives = 92/145 (63%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E +L++L+ S+ P + I+ + +Q+ + L ++H G HRDLKP N+L+ Sbjct: 96 IYFVTELQGTDLHRLLTSR--PLEKQFIQYFTYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR I +P T YVSTR+YRAPE++L Y + VD+W++G I++E+ Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILSEMI 211 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG + I +LG+P Sbjct: 212 EGKPLFPGKDHVHQFSIITELLGSP 236
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 119 bits (297), Expect = 7e-27 Identities = 68/157 (43%), Positives = 95/157 (60%), Gaps = 2/157 (1%) Frame = +1 Query: 55 VFEYMECNLYQLMKSKGKPFSETE-IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE 231 VFE+++ +L + P E I++ Q L +H HRDLKPEN+LVT Sbjct: 92 VFEHVDQDLKTYLSKVPPPGLPLETIKDLMKQFLSGLEFLHLNCIVHRDLKPENILVTSG 151 Query: 232 -LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + T V T WYRAPEVLLQS+ Y++ VD+W+ G I AE+F Sbjct: 152 GQVKLADFGLARIYSCQMALTPVVVTLWYRAPEVLLQST-YATPVDVWSAGCIFAEMFKR 210 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAAS 519 +PLF G+SEAD++ KI +I+G P++ W + L S Sbjct: 211 KPLFCGNSEADQLCKIFDIIGLPSEEEWPVDVTLPRS 247
>FUS3_YEAST (P16892) Mitogen-activated protein kinase FUS3 (EC 2.7.11.24) (MAP| kinase FUS3) Length = 353 Score = 119 bits (297), Expect = 7e-27 Identities = 65/157 (41%), Positives = 97/157 (61%), Gaps = 12/157 (7%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ + E M+ +L++++ ++ S+ I+ + +Q +A+ +H HRDLKP NLL+ Sbjct: 89 VYIIQELMQTDLHRVISTQ--MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN 146 Query: 226 KEL-IKVADFGLAREII------SEPP-----YTEYVSTRWYRAPEVLLQSSVYSSAVDM 369 +KV DFGLAR I SEP TEYV+TRWYRAPEV+L S+ YS A+D+ Sbjct: 147 SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDV 206 Query: 370 WAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPN 480 W+ G I+AELF RP+FPG ++ I I+GTP+ Sbjct: 207 WSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243
>CPK1_CRYNE (Q8NK05) Mitogen-activated protein kinase CPK1 (EC 2.7.11.24)| (Stress-activated protein kinase CPK1) Length = 366 Score = 119 bits (297), Expect = 7e-27 Identities = 60/154 (38%), Positives = 92/154 (59%), Gaps = 10/154 (6%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V E ME +L+++++S+ S+ + + +Q + L +H HRDLKP NLL+ Sbjct: 92 VYLVQELMETDLHRVIRSQ--ELSDDHCQYFVYQTLRGLKALHSADVLHRDLKPSNLLLN 149 Query: 226 KEL-IKVADFGLAREIISEPP---------YTEYVSTRWYRAPEVLLQSSVYSSAVDMWA 375 +K+ DFGLAR PP TEYV+TRWYRAPEV+L Y+ A+D+W+ Sbjct: 150 ANCDLKICDFGLARSSAKPPPGTSDGGQGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWS 209 Query: 376 MGAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 +G I+AE+ + +PLFPG ++ I +LGTP Sbjct: 210 VGCILAEMINGKPLFPGRDYHHQLSLILQVLGTP 243
>PMK2_CAEEL (Q8MXI4) Mitogen-activated protein kinase pmk-2 (EC 2.7.11.24) (p38| MAP kinase 2) (Stress-activated protein kinase pmk-2) Length = 419 Score = 118 bits (296), Expect = 9e-27 Identities = 63/168 (37%), Positives = 95/168 (56%), Gaps = 18/168 (10%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV M +L +MK + ++ +I+ +QV + L ++H G HRDLKP N+ V Sbjct: 127 VYFVSVLMGSDLQNIMKIQR--LTDEQIQLLIYQVLRGLKYIHSAGIIHRDLKPSNIAVN 184 Query: 226 KE------------------LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVY 351 + K+ DFGLAR +E T YV+TRWYRAPE++L Y Sbjct: 185 ERCEVKVFLSFSQLSFLILSFFKILDFGLARAQDAE--MTGYVATRWYRAPEIMLNWMHY 242 Query: 352 SSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWA 495 + VD+W++G I+AEL S RPLFPG D++ KI +++GTP + W+ Sbjct: 243 TQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWS 290
>CD2L5_HUMAN (Q14004) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) Length = 1512 Score = 118 bits (296), Expect = 9e-27 Identities = 61/157 (38%), Positives = 95/157 (60%), Gaps = 3/157 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFEYM+ +L L++S F+E I+++ Q+ + L + H++ + HRD+K N+L+ Sbjct: 788 YLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN 847 Query: 229 E-LIKVADFGLAREIISEP--PYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 IK+ADFGLAR SE PYT V T WYR PE+LL Y+ A+D+W+ G I+ EL Sbjct: 848 RGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL 907 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 F+ +P+F + E ++ I I G+P W ++L Sbjct: 908 FTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKL 944
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 118 bits (296), Expect = 9e-27 Identities = 60/156 (38%), Positives = 99/156 (63%), Gaps = 7/156 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKG-----KPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 L VFE+M+ +L + M S+ + ++ + +Q+ Q L+ H+ HRDLKP+ Sbjct: 78 LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQ 137 Query: 211 NLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 NLL+ K +K+ DFGLAR I ++ V T WYRAP+VL+ S YS+++D+W+ G Sbjct: 138 NLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGC 197 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 I+AE+ + +PLFPG+++ +++ I +I+GTPN+ W Sbjct: 198 ILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233
>CD2L5_MOUSE (Q69ZA1) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) Length = 1511 Score = 118 bits (296), Expect = 9e-27 Identities = 61/157 (38%), Positives = 95/157 (60%), Gaps = 3/157 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFEYM+ +L L++S F+E I+++ Q+ + L + H++ + HRD+K N+L+ Sbjct: 788 YLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN 847 Query: 229 E-LIKVADFGLAREIISEP--PYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 IK+ADFGLAR SE PYT V T WYR PE+LL Y+ A+D+W+ G I+ EL Sbjct: 848 RGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL 907 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 F+ +P+F + E ++ I I G+P W ++L Sbjct: 908 FTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKL 944
>MPK7_ARATH (Q39027) Mitogen-activated protein kinase homolog 7 (EC 2.7.11.24)| (MAP kinase 7) (AtMPK7) Length = 368 Score = 118 bits (296), Expect = 9e-27 Identities = 57/148 (38%), Positives = 94/148 (63%), Gaps = 2/148 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q++KS + S+ + + FQ+ + L ++H HRDLKP NLLV Sbjct: 109 VYLVYELMDTDLHQIIKSS-QSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVN 167 Query: 226 KEL-IKVADFGLAREIISEPPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +K+ DFGLAR + TEYV TRWYRAPE+LL Y +++D+W++G I AE+ Sbjct: 168 ANCDLKICDFGLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEI 227 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQ 483 +P+FPG+ +++ I N++G+ + Sbjct: 228 LGRKPIFPGTECLNQLKLIINVVGSQQE 255
>BUR1_KLULA (Q6CRA9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 645 Score = 118 bits (296), Expect = 9e-27 Identities = 57/171 (33%), Positives = 93/171 (54%), Gaps = 14/171 (8%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT- 225 F + YM +L L+ + F +++N Q+ + ++++H + HRD+K N+L+ Sbjct: 159 FMILPYMVSDLTGLLHNPRVEFGMADVKNIMLQLLEGINYIHCNKFLHRDIKTANILIDH 218 Query: 226 KELIKVADFGLAREIISEPP-------------YTEYVSTRWYRAPEVLLQSSVYSSAVD 366 K ++K+ADFGLAR PP YT V TRWYRAPE++L Y++AVD Sbjct: 219 KGVVKIADFGLARNYYGSPPNLKYPGGAGSGAKYTSVVVTRWYRAPEIVLGDRHYTTAVD 278 Query: 367 MWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAAS 519 +W +G + AE F +P+ G ++ D+ + I ++GTP+ W L S Sbjct: 279 IWGIGCVFAEFFEKKPILQGQTDIDQGHVIFKLMGTPSMDEWGLAYHLPGS 329
>STY1_SCHPO (Q09892) Mitogen-activated protein kinase sty1 (EC 2.7.11.24) (MAP| kinase sty1) (MAP kinase spc1) Length = 349 Score = 118 bits (295), Expect = 1e-26 Identities = 59/145 (40%), Positives = 90/145 (62%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E + +L++L+ S+ P I+ + +Q+ + L +H G HRDLKP N+L+ Sbjct: 93 IYFVTELLGTDLHRLLTSR--PLETQFIQYFLYQILRGLKFVHSAGVIHRDLKPSNILIN 150 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR I +P T YVSTR+YRAPE++L Y+ VD+W+ G I AE+ Sbjct: 151 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMI 208 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG ++ I +LGTP Sbjct: 209 EGKPLFPGRDHVNQFSIITELLGTP 233
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 117 bits (294), Expect = 2e-26 Identities = 54/143 (37%), Positives = 87/143 (60%), Gaps = 2/143 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFE+++ + ++ ++ + FQ+ + H HRD+KPEN+LV++ Sbjct: 77 YLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 229 E-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++K+ DFG AR + + YT+YV+TRWYRAPE+L+ Y AVD+WA+G ++ E+F Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF 196 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 PLFPG S+ D++Y I LG Sbjct: 197 MGEPLFPGDSDIDQLYHIMMCLG 219
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 117 bits (294), Expect = 2e-26 Identities = 61/145 (42%), Positives = 93/145 (64%), Gaps = 3/145 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY + + + + E +++ +Q QA++ H++ HRD+KPEN+L+T Sbjct: 76 LHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILIT 135 Query: 226 K-ELIKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 K ++IK+ DFG AR I++ P YT+ V+TRWYRAPE+L+ + Y VD+WA+G + AE Sbjct: 136 KHQVIKLCDFGFAR-ILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAE 194 Query: 397 LFSHRPLFPGSSEADEIYKICNILG 471 L S PL+PG S+ D++Y I LG Sbjct: 195 LLSGAPLWPGKSDVDQLYLIRKTLG 219
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 117 bits (294), Expect = 2e-26 Identities = 60/145 (41%), Positives = 92/145 (63%), Gaps = 3/145 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY + + + + E +++ +Q QA++ H+ HRD+KPEN+L+T Sbjct: 76 LHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILIT 135 Query: 226 KE-LIKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 K +IK+ DFG AR +++ P YT+YV+TRWYR+PE+L+ + Y VD+WA+G + AE Sbjct: 136 KHSVIKLCDFGFAR-LLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAE 194 Query: 397 LFSHRPLFPGSSEADEIYKICNILG 471 L S PL+PG S+ D++Y I LG Sbjct: 195 LLSGVPLWPGKSDVDQLYLIRKTLG 219
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 117 bits (294), Expect = 2e-26 Identities = 54/143 (37%), Positives = 87/143 (60%), Gaps = 2/143 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFE+++ + ++ ++ + FQ+ + H HRD+KPEN+LV++ Sbjct: 77 YLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 229 E-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++K+ DFG AR + + YT+YV+TRWYRAPE+L+ Y AVD+WA+G ++ E+F Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF 196 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 PLFPG S+ D++Y I LG Sbjct: 197 MGEPLFPGDSDIDQLYHIMMCLG 219
>KSS1_YEAST (P14681) Mitogen-activated protein kinase KSS1 (EC 2.7.11.24) (MAP| kinase KSS1) (Kinase suppressor of SST2) Length = 368 Score = 117 bits (294), Expect = 2e-26 Identities = 60/157 (38%), Positives = 96/157 (61%), Gaps = 12/157 (7%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFS---ETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 ++ V E ME +L +++ ++ FS + ++ + +Q+ +AL +H HRD+KP NL Sbjct: 90 VYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNL 149 Query: 217 LVTKEL-IKVADFGLAREIISEPP--------YTEYVSTRWYRAPEVLLQSSVYSSAVDM 369 L+ +KV DFGLAR + S TEYV+TRWYRAPE++L Y++A+D+ Sbjct: 150 LLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDI 209 Query: 370 WAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPN 480 W+ G I+AE+ S +PLFPG +++ I +LGTP+ Sbjct: 210 WSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPS 246
>CCRK_RAT (Q4KM34) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 117 bits (294), Expect = 2e-26 Identities = 55/148 (37%), Positives = 91/148 (61%), Gaps = 3/148 (2%) Frame = +1 Query: 58 FEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE-L 234 FE+M +L ++++ +P + +++++ + + ++ H HRDLKP NLL++ Sbjct: 81 FEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQ 140 Query: 235 IKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + YT V+TRWYRAPE+L + Y VD+WA+G I+ EL + Sbjct: 141 LKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNG 200 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTW 492 PLFPG ++ +++ + ILGTP+ W Sbjct: 201 SPLFPGENDIEQLCCVLRILGTPSPRVW 228
>CCRK_MOUSE (Q9JHU3) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) Length = 346 Score = 117 bits (294), Expect = 2e-26 Identities = 55/148 (37%), Positives = 91/148 (61%), Gaps = 3/148 (2%) Frame = +1 Query: 58 FEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE-L 234 FE+M +L ++++ +P + +++++ + + ++ H HRDLKP NLL++ Sbjct: 81 FEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQ 140 Query: 235 IKVADFGLAREIISEPP--YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSH 408 +K+ADFGLAR + YT V+TRWYRAPE+L + Y VD+WA+G I+ EL + Sbjct: 141 LKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNG 200 Query: 409 RPLFPGSSEADEIYKICNILGTPNQHTW 492 PLFPG ++ +++ + ILGTP+ W Sbjct: 201 SPLFPGENDIEQLCCVLRILGTPSPRVW 228
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 117 bits (293), Expect = 2e-26 Identities = 61/157 (38%), Positives = 95/157 (60%), Gaps = 3/157 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFEYM+ +L L++S FSE I+++ Q+ + L + H++ + HRD+K N+L+ Sbjct: 810 YLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNN 869 Query: 229 E-LIKVADFGLAREIISEP--PYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 IK+ADFGLAR SE PYT V T WYR PE+LL Y+ A+D+W+ G I+ EL Sbjct: 870 SGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL 929 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 F+ +P+F + E ++ I + G+P W ++L Sbjct: 930 FTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKL 966
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 117 bits (293), Expect = 2e-26 Identities = 58/151 (38%), Positives = 90/151 (59%), Gaps = 2/151 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFEY++ +L + + + I+++ + + ++ HQR HRDLKP+NLL++ Sbjct: 77 LTIVFEYLDLDLKKYLDRENGNLDAATIQHFMRDLLRGVAFCHQRSVLHRDLKPQNLLIS 136 Query: 226 KEL-IKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +E +K+ DFGL R I +T V T WYR P+VLL S Y VD+W++G I +E+ Sbjct: 137 REKELKLGDFGLGRSFAIPVRKFTNEVVTLWYRPPDVLLGSMQYGPPVDVWSVGCIFSEM 196 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + PLF G ++AD++ +I LGTPN W Sbjct: 197 ATGTPLFAGKNDADQLMRIFRFLGTPNNRVW 227
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 117 bits (293), Expect = 2e-26 Identities = 53/143 (37%), Positives = 87/143 (60%), Gaps = 2/143 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFE+++ + ++ + ++ + FQ+ + H HRD+KPEN+LV++ Sbjct: 77 YLVFEFVDHTILDDLELFPNGLDDQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 229 E-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++K+ DFG AR + + YT+YV+TRWYRAPE+L+ Y AVD+WA+G ++ E+ Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEML 196 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 PLFPG S+ D++Y I LG Sbjct: 197 MGEPLFPGDSDIDQLYLIMRCLG 219
>MAPK_PETHY (Q40884) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (PMEK1) Length = 384 Score = 117 bits (293), Expect = 2e-26 Identities = 57/148 (38%), Positives = 94/148 (63%), Gaps = 2/148 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q++KS + S + + FQ+ + L ++H HRDLKP NLL+ Sbjct: 109 VYLVYELMDTDLHQIIKSS-QTLSNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLIN 167 Query: 226 KEL-IKVADFGLAREIISEPPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +K+ DFGLAR + + TEYV TRWYRAPE+LL Y +++D+W++G I A++ Sbjct: 168 ANCDLKICDFGLARTSSGKDQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFADV 227 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQ 483 +P+FPG+ +++ I NILG+ + Sbjct: 228 LGRKPVFPGTECLNQLKLIINILGSQRE 255
>KIN28_YEAST (P06242) Serine/threonine-protein kinase KIN28 (EC 2.7.11.23)| Length = 306 Score = 117 bits (293), Expect = 2e-26 Identities = 62/153 (40%), Positives = 87/153 (56%), Gaps = 2/153 (1%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 D L V E++ +L ++K K F+ +I+ W + + H H+ HRDLKP NLL Sbjct: 77 DNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLL 136 Query: 220 VTKE-LIKVADFGLAREIISEPPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIA 393 + + IKVADFGLAR I + T V TRWYRAPE+L + Y+SA+D+W++G I A Sbjct: 137 FSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFA 196 Query: 394 ELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 EL P PG ++ D++ LGTP W Sbjct: 197 ELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDW 229
>KSG2_ARATH (O23145) Shaggy-related protein kinase beta (EC 2.7.11.1)| (ASK-beta) Length = 431 Score = 117 bits (292), Expect = 3e-26 Identities = 61/156 (39%), Positives = 98/156 (62%), Gaps = 8/156 (5%) Frame = +1 Query: 34 ENDMLFF--VFEYMECNLYQLMKSKGKPFSETE---IRNWCFQVFQALSHMHQR-GYFHR 195 E D L+ V EY+ +Y+ +S K I+ + +Q+ +A++++HQ G HR Sbjct: 167 EKDELYLNLVLEYVPETIYRASRSYTKMNQHMPLIYIQLYTYQICRAMNYLHQVVGVCHR 226 Query: 196 DLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDM 369 D+KP+NLLV +K+ DFG A+ +I P Y+ +R+YRAPE++ ++ Y+SA+DM Sbjct: 227 DIKPQNLLVNNVTHEVKICDFGSAKMLIPGEPNISYICSRYYRAPELIFGATEYTSAIDM 286 Query: 370 WAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 W++G ++AELF PLFPG + D++ +I ILGTP Sbjct: 287 WSVGCVMAELFLGHPLFPGETSVDQLVEIIKILGTP 322
>SMK1_YEAST (P41808) Sporulation-specific mitogen-activated protein kinase SMK1| (EC 2.7.11.24) (MAP kinase SMK1) Length = 388 Score = 116 bits (291), Expect = 3e-26 Identities = 61/158 (38%), Positives = 97/158 (61%), Gaps = 10/158 (6%) Frame = +1 Query: 40 DMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLL 219 D L+ E ++ +L +++ S + SE I+ + +Q+ L ++H HRDLKP N+L Sbjct: 115 DGLYCYQELIDYDLAKVIHSSVQ-LSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNIL 173 Query: 220 VTKE-LIKVADFGLAREIIS---------EPPYTEYVSTRWYRAPEVLLQSSVYSSAVDM 369 T +K+ DFGLAR I + +P T YV+TRWYRAPE+LL + YS +VD+ Sbjct: 174 CTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDI 233 Query: 370 WAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 WA+G I+AE ++ +P+F G +I++I +LGTP++ Sbjct: 234 WAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDK 271
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 116 bits (291), Expect = 3e-26 Identities = 56/145 (38%), Positives = 92/145 (63%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E +L++L++++ P + ++ + +Q+ + L ++H G HRDLKP N+L+ Sbjct: 96 IYFVTELQGTDLHRLLQTR--PLEKQFLQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR I +P T YVSTR+YRAPE++L Y+ VD+W+ G I AE+ Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMI 211 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG + I ++LG+P Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSP 236
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 116 bits (291), Expect = 3e-26 Identities = 56/145 (38%), Positives = 91/145 (62%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E +L++L++++ P + ++ + +Q+ + L ++H G HRDLKP N+L+ Sbjct: 96 IYFVTELQGTDLHRLLQTR--PLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR I +P T YVSTR+YRAPE++L Y VD+W+ G I AE+ Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMI 211 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG + I ++LG+P Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSP 236
>GSK3A_HUMAN (P49840) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) Length = 483 Score = 116 bits (290), Expect = 5e-26 Identities = 53/151 (35%), Positives = 101/151 (66%), Gaps = 5/151 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMK--SKGK-PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L V EY+ +Y++ + +K K ++ + +Q+F++L+++H +G HRD+KP+NL Sbjct: 191 LNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNL 250 Query: 217 LVTKE--LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LV + ++K+ DFG A++++ P Y+ +R+YRAPE++ ++ Y+S++D+W+ G ++ Sbjct: 251 LVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVL 310 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 AEL +P+FPG S D++ +I +LGTP + Sbjct: 311 AELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 341
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 116 bits (290), Expect = 5e-26 Identities = 60/146 (41%), Positives = 91/146 (62%), Gaps = 1/146 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M +L +LMK + SE ++ +Q+ + L ++H G HRDLKP NL + + Sbjct: 104 YLVMPFMGTDLGKLMKMER--LSEERVQYLVYQMLKGLKYIHAAGIIHRDLKPGNLAINE 161 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 E +K+ DFGLAR+ SE T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ Sbjct: 162 ECELKILDFGLARQTDSE--MTGYVVTRWYRAPEVILSWMHYTQTVDIWSVGCIMAEMLL 219 Query: 406 HRPLFPGSSEADEIYKICNILGTPNQ 483 +PLF G D++ +I + GTP++ Sbjct: 220 GKPLFKGHDHLDQLMEIMKVTGTPSK 245
>BUR1_ASHGO (Q75D46) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 753 Score = 116 bits (290), Expect = 5e-26 Identities = 54/162 (33%), Positives = 91/162 (56%), Gaps = 14/162 (8%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT- 225 + + YM +L ++ + +I+N Q+ + ++++H + + HRD+K N+L+ Sbjct: 152 YMILPYMVADLSGILHNPRVTLEMADIKNMMLQILEGINYIHCKKFMHRDIKTANILLDH 211 Query: 226 KELIKVADFGLAREIISEPP-------------YTEYVSTRWYRAPEVLLQSSVYSSAVD 366 K ++K+ADFGLAR PP YT V TRWYRAPE++L Y++AVD Sbjct: 212 KGILKIADFGLARNYYGAPPNLKYPGGAGTDAKYTSVVVTRWYRAPELVLGDKNYTTAVD 271 Query: 367 MWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 +W +G + AE F RP+ G ++ D+ + I ++GTP+ W Sbjct: 272 IWGIGCVFAEFFEKRPILQGKTDIDQGHVIFKLMGTPSDSDW 313
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 116 bits (290), Expect = 5e-26 Identities = 61/152 (40%), Positives = 92/152 (60%), Gaps = 3/152 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ + +L + S ++++ FQ+ + L H R HRDLKP+NLL+ Sbjct: 76 LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR I Y+ V T WYR+P+VL + +YS+++DMW+ G I AEL Sbjct: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRSPDVLFGAKLYSTSIDMWSAGCIFAEL 195 Query: 400 F-SHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG+ D++ +I +LGTP + W Sbjct: 196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227
>MPK1_ARATH (Q39021) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (MAP kinase 1) (AtMPK1) Length = 370 Score = 116 bits (290), Expect = 5e-26 Identities = 59/148 (39%), Positives = 94/148 (63%), Gaps = 2/148 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V+E M+ +L+Q++KS + S + + FQ+ + L ++H HRDLKP NLLV Sbjct: 109 VYLVYELMDTDLHQIIKSS-QVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVN 167 Query: 226 KEL-IKVADFGLAREIISEPPY-TEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +K+ DFGLAR ++ + TEYV TRWYRAPE+LL Y +++D+W++G I AEL Sbjct: 168 ANCDLKICDFGLARASNTKGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEL 227 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQ 483 +P+F G+ +++ I NILG+ + Sbjct: 228 LGRKPIFQGTECLNQLKLIVNILGSQRE 255
>CDK7_DICDI (P54685) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (MO15 homolog) Length = 362 Score = 116 bits (290), Expect = 5e-26 Identities = 61/163 (37%), Positives = 95/163 (58%), Gaps = 2/163 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ VFE M+ +L ++++ K +I+++ + Q + H+ HRDLKP NLL++ Sbjct: 80 VYLVFELMQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMS 139 Query: 226 -KELIKVADFGLAREIIS-EPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 +K+ADFGLAR+ S ++ T +YRAPE+L + Y +VD+W++G I AEL Sbjct: 140 INGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAEL 199 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLAASIHF 528 P PG+ E D++ KIC+ LGTPN+ W G L I F Sbjct: 200 MLRTPYLPGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKF 242
>GSK3A_RAT (P18265) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) (Factor A) (FA) Length = 483 Score = 115 bits (289), Expect = 6e-26 Identities = 52/151 (34%), Positives = 99/151 (65%), Gaps = 5/151 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKP---FSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L V EY+ +Y++ + K ++ + +Q+F++L+++H +G HRD+KP+NL Sbjct: 191 LNLVLEYVPETVYRVARHFTKAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNL 250 Query: 217 LVTKE--LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 LV + ++K+ DFG A++++ P Y+ +R+YRAPE++ ++ Y+S++D+W+ G ++ Sbjct: 251 LVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVL 310 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 AEL +P+FPG S D++ +I +LGTP + Sbjct: 311 AELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 341
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 115 bits (289), Expect = 6e-26 Identities = 53/143 (37%), Positives = 87/143 (60%), Gaps = 2/143 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFE+++ + +K ++ + FQ+ + H HRD+KPEN+LV++ Sbjct: 77 YLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 229 E-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++K+ DFG AR + + YT+YV+TRWYRAPE+L+ Y AVD+WA+G ++ E+ Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEML 196 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 +PLFPG S+ D+++ I LG Sbjct: 197 MGQPLFPGESDIDQLHHIMTCLG 219
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 115 bits (289), Expect = 6e-26 Identities = 53/143 (37%), Positives = 87/143 (60%), Gaps = 2/143 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + VFE+++ + +K ++ + FQ+ + H HRD+KPEN+LV++ Sbjct: 77 YLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 229 E-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++K+ DFG AR + + YT+YV+TRWYRAPE+L+ Y AVD+WA+G ++ E+ Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEML 196 Query: 403 SHRPLFPGSSEADEIYKICNILG 471 +PLFPG S+ D+++ I LG Sbjct: 197 MGQPLFPGESDIDQLHHIMTCLG 219
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 115 bits (288), Expect = 8e-26 Identities = 56/145 (38%), Positives = 91/145 (62%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E +L++L++++ P + ++ + +Q+ + L ++H G HRDLKP N+L+ Sbjct: 96 IYFVTELQGTDLHRLLQTR--PLEKQFVQYFHYQILRGLKYVHSAGVVHRDLKPSNILIN 153 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR I +P T YVSTR+YRAPE++L Y VD+W+ G I AE+ Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMI 211 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG + I ++LG+P Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSP 236
>PMK1_CAEEL (Q17446) Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (p38| MAP kinase 1) (Stress-activated protein kinase pmk-1) Length = 377 Score = 115 bits (288), Expect = 8e-26 Identities = 57/147 (38%), Positives = 94/147 (63%), Gaps = 1/147 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV M +L ++K + ++ I+ +Q+ + L ++H HRDLKP N+ V Sbjct: 113 VYFVSMLMGADLSNILKIQR--LNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVN 170 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++ +K+ DFGLAR+ SE T YV+TRWYRAPE++L Y+ VD+W++G I+AEL Sbjct: 171 EDCELKILDFGLARQTDSE--MTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELI 228 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQ 483 + + LFPGS D++ +I ++ GTP++ Sbjct: 229 TGKTLFPGSDHIDQLTRIMSVTGTPDE 255
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 115 bits (288), Expect = 8e-26 Identities = 61/152 (40%), Positives = 91/152 (59%), Gaps = 3/152 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ + +L + S ++++ FQ+ + L H R HRDLKP+NLL+ Sbjct: 76 LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR I Y+ V T WYR P+VL + +YS+++DMW+ G I AEL Sbjct: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 Query: 400 F-SHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG+ D++ +I +LGTP + W Sbjct: 196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 115 bits (288), Expect = 8e-26 Identities = 61/152 (40%), Positives = 91/152 (59%), Gaps = 3/152 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ + +L + S ++++ FQ+ + L H R HRDLKP+NLL+ Sbjct: 76 LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR I Y+ V T WYR P+VL + +YS+++DMW+ G I AEL Sbjct: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 Query: 400 F-SHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG+ D++ +I +LGTP + W Sbjct: 196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 115 bits (288), Expect = 8e-26 Identities = 55/145 (37%), Positives = 91/145 (62%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++FV E +L++L++++ P + ++ + +Q+ + L ++H G HRDLKP N+L+ Sbjct: 96 IYFVTELQGTDLHRLLQTR--PLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR I +P T YVSTR+YRAPE++L Y VD+W+ G I +E+ Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFSEMI 211 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 +PLFPG + I ++LG+P Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSP 236
>KSG1_ARATH (P43288) Shaggy-related protein kinase alpha (EC 2.7.11.1)| (ASK-alpha) Length = 405 Score = 115 bits (287), Expect = 1e-25 Identities = 61/169 (36%), Positives = 104/169 (61%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMKSKGKPFSETE---IRNWCFQVFQALS 165 KHC S E D L+ V EY+ +++++K K ++ + +Q+F+ALS Sbjct: 126 KHCFF---STTEKDELYLNLVLEYVPETVHRVIKHYNKLNQRMPLIYVKLYTYQIFRALS 182 Query: 166 HMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H+ G HRD+KP+NLLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 183 YIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 242 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++A+D+W+ G ++AEL +PLFPG S D++ +I +LGTP + Sbjct: 243 GATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR 291
>BUR1_CANGA (Q6FQ83) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 667 Score = 115 bits (287), Expect = 1e-25 Identities = 54/162 (33%), Positives = 91/162 (56%), Gaps = 14/162 (8%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + + YM +L ++ + +I+N Q+ + ++ +H + HRD+K NLL+ Sbjct: 158 YMILPYMVADLSGILHNPRIELKMADIKNMMKQILEGVNFIHCSKFMHRDIKTANLLIDH 217 Query: 229 E-LIKVADFGLAREIISEPP-------------YTEYVSTRWYRAPEVLLQSSVYSSAVD 366 ++K+ADFGLAR+ PP YT V TRWYRAPE++L Y++AVD Sbjct: 218 NGVLKLADFGLARQYYGSPPNIKFPGSAGSGAKYTSVVVTRWYRAPELVLGDKYYTTAVD 277 Query: 367 MWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 +W +G + AE F +P+ G ++ D+ + I ++GTP++ TW Sbjct: 278 IWGVGCVFAEFFEKKPILQGKTDIDQGHVIFKLMGTPDERTW 319
>CDKL3_RAT (Q9JM01) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIATRE) Length = 593 Score = 115 bits (287), Expect = 1e-25 Identities = 55/151 (36%), Positives = 93/151 (61%), Gaps = 4/151 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFE+++ + ++ +R + FQ+ +A+ ++H HRD+KPEN+LV+ Sbjct: 75 IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVS 134 Query: 226 KE-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + + K+ DFG AR + + YT+YV+TRWYRAPE++L+ + Y VD+WA+G +I E+ Sbjct: 135 QSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTTYGKPVDIWALGCMIIEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILG--TPNQH 486 + P P SS+ D ++KI +G TP+ H Sbjct: 195 ATGNPYLPSSSDLDLLHKIVLKVGNLTPHLH 225
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 115 bits (287), Expect = 1e-25 Identities = 61/163 (37%), Positives = 99/163 (60%), Gaps = 7/163 (4%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETE-----IRNWCFQVFQALSHMHQRGYFHRDLKPE 210 L VFE+M+ +L + M ++ K S ++ + +Q+ Q ++ H+ HRDLKP+ Sbjct: 78 LTLVFEFMDNDLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHENRILHRDLKPQ 137 Query: 211 NLLVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGA 384 NLL+ +K+ DFGLAR I ++ V T WYRAP+VL+ S Y +++D+W+ G Sbjct: 138 NLLINNRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRNYCTSIDIWSCGC 197 Query: 385 IIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQLA 513 I+AE+ +PLFPGS++ +++ I + +GTP + TW QLA Sbjct: 198 ILAEMIMGKPLFPGSNDEEQLKLIFDTMGTPVEQTWPQVTQLA 240
>MK15_HUMAN (Q8TD08) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 8) Length = 544 Score = 114 bits (286), Expect = 1e-25 Identities = 63/158 (39%), Positives = 96/158 (60%), Gaps = 8/158 (5%) Frame = +1 Query: 34 ENDM-LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPE 210 END ++ VFE+M+ +L +++ KG + +R+ +Q+ +A +H HRD KP Sbjct: 83 ENDRDIYLVFEFMDTDLNAVIR-KGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPS 141 Query: 211 NLLVTKEL-IKVADFGLAREI--ISEPP----YTEYVSTRWYRAPEVLLQSSVYSSAVDM 369 N+L+ +K+ DFGLAR + + E P TEYV+TRWYRAPEVLL S Y+ VDM Sbjct: 142 NVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDM 201 Query: 370 WAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 W++G I+ E+ RPLFPG+S ++ I + P++ Sbjct: 202 WSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSE 239
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 114 bits (286), Expect = 1e-25 Identities = 55/151 (36%), Positives = 93/151 (61%), Gaps = 4/151 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFE+++ + ++ +R + FQ+ +A+ ++H HRD+KPEN+LV+ Sbjct: 75 IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVS 134 Query: 226 KE-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + + K+ DFG AR + + YT+YV+TRWYRAPE++L+ + Y VD+WA+G +I E+ Sbjct: 135 QSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILG--TPNQH 486 + P P SS+ D ++KI +G TP+ H Sbjct: 195 ATGHPFLPSSSDLDLLHKIVLKVGNLTPHLH 225
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 114 bits (286), Expect = 1e-25 Identities = 60/152 (39%), Positives = 92/152 (60%), Gaps = 3/152 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ + +L + S ++++ +Q+ + L+ H R HRDLKP+NLL+ Sbjct: 76 LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR I Y+ V T WYR P+VL + +YS+++DMW+ G I AEL Sbjct: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 Query: 400 F-SHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG+ D++ +I +LGTP + W Sbjct: 196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227
>CTK1_YEAST (Q03957) CTD kinase subunit alpha (EC 2.7.11.23) (CTD kinase 58 kDa| subunit) (CTDK-I alpha subunit) Length = 528 Score = 114 bits (286), Expect = 1e-25 Identities = 54/150 (36%), Positives = 91/150 (60%), Gaps = 1/150 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ +FEY + +L L+ +K S ++ ++ Q+ + ++H HRD+K N+L+ Sbjct: 256 VYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILID 315 Query: 226 KE-LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR++ S YT V T WYR PE+LL ++ Y + VDMW G ++ ELF Sbjct: 316 NQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELF 375 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + +F GS+E ++I I I+GTP ++W Sbjct: 376 NKTAIFQGSNELEQIESIFKIMGTPTINSW 405
>BUR1_YARLI (Q6C842) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 706 Score = 114 bits (285), Expect = 2e-25 Identities = 58/175 (33%), Positives = 96/175 (54%), Gaps = 12/175 (6%) Frame = +1 Query: 10 EAQGRS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYF 189 E +S E ++ V YM+ +L L+ ++ S I+ + Q+ + + ++H + + Sbjct: 106 ERGDQSKKERGCVYMVTPYMDHDLAGLLGNQSVQLSPAHIKCYMLQLLEGIGYLHAKKFL 165 Query: 190 HRDLKPENLLVTKE-LIKVADFGLAREIISEPP-----------YTEYVSTRWYRAPEVL 333 HRD+K N+LV + ++K+ADFGLAR P T V TRWYR PE++ Sbjct: 166 HRDIKAANILVNDQGILKLADFGLARGYDGPAPNSQTAGVNTENLTAMVVTRWYRPPELI 225 Query: 334 LQSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 L Y++A+DMW +G + E F+ +P+FPG+S+ D+ KI +G P + T G Sbjct: 226 LGDRKYTTAIDMWGIGCVFGEFFTRKPIFPGASDVDQGSKIFQAVGVPTEDTMPG 280
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 114 bits (285), Expect = 2e-25 Identities = 46/121 (38%), Positives = 87/121 (71%), Gaps = 2/121 (1%) Frame = +1 Query: 127 IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE--LIKVADFGLAREIISEPPYTEYV 300 ++ + +Q+F++L+++H G HRD+KP+NLL+ + ++K+ DFG A++++ P Y+ Sbjct: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Query: 301 STRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPN 480 +R+YRAPE++ ++ Y+S++DMW+ G ++AEL +P+FPG S D++ +I +LGTP Sbjct: 218 CSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Query: 481 Q 483 + Sbjct: 278 R 278
>SGG_DROME (P18431) Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white 3)| Length = 1067 Score = 114 bits (285), Expect = 2e-25 Identities = 52/151 (34%), Positives = 96/151 (63%), Gaps = 5/151 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEI---RNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L V EY+ +Y++ + K I R + +Q+F++L+++H G HRD+KP+NL Sbjct: 679 LNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNL 738 Query: 217 LVTKE--LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E ++K+ DFG A++++ P Y+ +R+YRAPE++ + Y++ +D+W+ G ++ Sbjct: 739 LLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVL 798 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 AEL +P+FPG S D++ ++ +LGTP + Sbjct: 799 AELLLGQPIFPGDSGVDQLVEVIKVLGTPTR 829
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 114 bits (285), Expect = 2e-25 Identities = 61/152 (40%), Positives = 90/152 (59%), Gaps = 3/152 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 L VFE+ + +L + S +++ FQ+ + L H R HRDLKP+NLL+ Sbjct: 76 LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLIN 135 Query: 226 KE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + +K+ADFGLAR I Y+ V T WYR P+VL + +YS+++DMW+ G I AEL Sbjct: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 Query: 400 F-SHRPLFPGSSEADEIYKICNILGTPNQHTW 492 + RPLFPG+ D++ +I +LGTP + W Sbjct: 196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227
>MSK1_TOBAC (Q40518) Shaggy-related protein kinase NtK-1 (EC 2.7.11.1)| Length = 409 Score = 114 bits (285), Expect = 2e-25 Identities = 60/169 (35%), Positives = 103/169 (60%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMKSKGKPFSETE---IRNWCFQVFQALS 165 KHC S E D ++ V EY+ +++++K K ++ + +Q+F+ALS Sbjct: 130 KHCFF---STTEKDEVYLNLVLEYVPETVHRVIKHYNKLNQRMPLILVKLYTYQIFRALS 186 Query: 166 HMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H G HRD+KP+NLLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 187 YIHHTIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 246 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++A+D+W+ G ++AEL +PLFPG S D++ +I +LGTP + Sbjct: 247 GATEYTTAIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR 295
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 114 bits (284), Expect = 2e-25 Identities = 62/164 (37%), Positives = 96/164 (58%), Gaps = 9/164 (5%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK-------GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLK 204 L VFE+M+ +L + M S+ G S + W Q+ Q ++ H+ HRDLK Sbjct: 80 LTLVFEFMDNDLKKFMDSRLDREMPRGLELSLVKYFQW--QLLQGVAFCHENRILHRDLK 137 Query: 205 PENLLVT-KELIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 P+NLL+ K +K+ DFGLAR I ++ V T WYRAP+VL+ S Y +++D+W+ Sbjct: 138 PQNLLINNKGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYCTSIDIWSC 197 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAGGLQL 510 G I+AE+ + LFPG+++ +++ I +GTP + TW G QL Sbjct: 198 GCILAEMIMGKALFPGTNDDEQLKLIFETMGTPTEQTWVGVSQL 241
>CDKL3_MACFA (Q4R8T9) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 590 Score = 114 bits (284), Expect = 2e-25 Identities = 53/149 (35%), Positives = 91/149 (61%), Gaps = 2/149 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFE+++ + ++ +R + FQ+ +A+ ++H HRD+KPEN+LV+ Sbjct: 75 IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVS 134 Query: 226 KE-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + + K+ DFG AR + + YT+YV+TRWYRAPE++L+ + Y VD+WA+G +I E+ Sbjct: 135 QSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQH 486 + P P SS+ D ++KI +G + H Sbjct: 195 ATGNPYLPSSSDLDLLHKIVLKVGNLSPH 223
>MSK1_MEDSA (P51137) Glycogen synthase kinase-3 homolog MsK-1 (EC 2.7.11.1)| Length = 411 Score = 114 bits (284), Expect = 2e-25 Identities = 60/169 (35%), Positives = 104/169 (61%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMKSKGKPFSETE---IRNWCFQVFQALS 165 KHC S E D L+ V EY+ +++++K K ++ + +Q+F+ALS Sbjct: 132 KHCFF---STTEKDELYLNLVLEYVPETVHRVIKHYSKLNQRMPMIYVKLYTYQIFRALS 188 Query: 166 HMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H+ G HRD+KP+NLLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 189 YIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 248 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++A+D+W++G ++AEL +PLFPG D++ +I +LGTP + Sbjct: 249 GATEYTTAIDVWSVGCVLAELLLGQPLFPGERGVDQLVEIIKVLGTPTR 297
>CDKL3_HUMAN (Q8IVW4) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIAMRE) Length = 592 Score = 114 bits (284), Expect = 2e-25 Identities = 53/149 (35%), Positives = 91/149 (61%), Gaps = 2/149 (1%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFE+++ + ++ +R + FQ+ +A+ ++H HRD+KPEN+LV+ Sbjct: 75 IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVS 134 Query: 226 KE-LIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 + + K+ DFG AR + + YT+YV+TRWYRAPE++L+ + Y VD+WA+G +I E+ Sbjct: 135 QSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEM 194 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQH 486 + P P SS+ D ++KI +G + H Sbjct: 195 ATGNPYLPSSSDLDLLHKIVLKVGNLSPH 223
>KSG7_ARATH (Q39011) Shaggy-related protein kinase eta (EC 2.7.11.1) (ASK-eta)| (BRASSINOSTEROID-INSENSITIVE 2) (ULTRACURVATA1) Length = 380 Score = 114 bits (284), Expect = 2e-25 Identities = 59/169 (34%), Positives = 103/169 (60%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMK---SKGKPFSETEIRNWCFQVFQALS 165 KHC S D LF V EY+ +LY+++K S + ++ + +Q+F+ L+ Sbjct: 97 KHCFFSTTS---KDELFLNLVMEYVPESLYRVLKHYSSANQRMPLVYVKLYMYQIFRGLA 153 Query: 166 HMHQ-RGYFHRDLKPENLLVTK--ELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H G HRDLKP+NLLV +K+ DFG A++++ Y+ +R+YRAPE++ Sbjct: 154 YIHNVAGVCHRDLKPQNLLVDPLTHQVKICDFGSAKQLVKGEANISYICSRFYRAPELIF 213 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++++D+W+ G ++AEL +PLFPG + D++ +I +LGTP + Sbjct: 214 GATEYTTSIDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTPTR 262
>KSG3_ARATH (P43289) Shaggy-related protein kinase gamma (EC 2.7.11.1)| (ASK-gamma) Length = 409 Score = 114 bits (284), Expect = 2e-25 Identities = 60/169 (35%), Positives = 104/169 (61%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMKSKGKPFSETE---IRNWCFQVFQALS 165 KHC S E D L+ V EY+ +++++K K ++ + +Q+F++LS Sbjct: 130 KHCFF---STTEKDELYLNLVLEYVPETVHRVIKHYNKLNQRMPLVYVKLYTYQIFRSLS 186 Query: 166 HMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H+ G HRD+KP+NLLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 187 YIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 246 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++A+D+W+ G ++AEL +PLFPG S D++ +I +LGTP + Sbjct: 247 GATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR 295
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 113 bits (283), Expect = 3e-25 Identities = 54/151 (35%), Positives = 96/151 (63%), Gaps = 5/151 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQ---LMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L V E+M +Y+ L + E++ + +Q+ ++L+++H G HRD+KP+NL Sbjct: 104 LNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNL 163 Query: 217 LVTKE--LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E ++K+ DFG A+ +++ P Y+ +R+YRAPE++ ++ Y+ A+D+W+ G ++ Sbjct: 164 LLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVM 223 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 AEL PLFPG S D++ +I ILGTP++ Sbjct: 224 AELMLGHPLFPGESGIDQLVEIIKILGTPSR 254
>MK12_MOUSE (O08911) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 113 bits (282), Expect = 4e-25 Identities = 61/144 (42%), Positives = 90/144 (62%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M +L +LMK + SE I+ +Q+ + L ++H G HRDLKP NL V + Sbjct: 106 YLVMPFMGTDLGKLMKHE--TLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNE 163 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR+ SE T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 164 DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF G+ D++ +I I GTP Sbjct: 222 GKILFKGNDHLDQLKEIMKITGTP 245
>KSG6_ARATH (Q39010) Shaggy-related protein kinase dzeta (EC 2.7.11.1)| (ASK-dzeta) Length = 412 Score = 112 bits (281), Expect = 5e-25 Identities = 60/169 (35%), Positives = 101/169 (59%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMK---SKGKPFSETEIRNWCFQVFQALS 165 KHC S D LF V EY+ LY+++K S + ++ + +Q+F+ L+ Sbjct: 129 KHCFF---STTTRDELFLNLVMEYVPETLYRVLKHYTSSNQRMPIFYVKLYTYQIFRGLA 185 Query: 166 HMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H G HRD+KP+NLLV K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 186 YIHTAPGVCHRDIKPQNLLVDPHTHQCKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 245 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y+S++D+W+ G ++AEL +PLFPG + D++ +I +LGTP + Sbjct: 246 GATEYTSSIDIWSAGCVLAELLLGQPLFPGENSVDQLVEIIKVLGTPTR 294
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 112 bits (281), Expect = 5e-25 Identities = 45/121 (37%), Positives = 87/121 (71%), Gaps = 2/121 (1%) Frame = +1 Query: 127 IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE--LIKVADFGLAREIISEPPYTEYV 300 ++ + +Q+F++L+++H G HRD+KP+NLL+ + ++K+ DFG A++++ P Y+ Sbjct: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Query: 301 STRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPN 480 +R+YRAPE++ ++ Y+S++D+W+ G ++AEL +P+FPG S D++ +I +LGTP Sbjct: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Query: 481 Q 483 + Sbjct: 278 R 278
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 112 bits (281), Expect = 5e-25 Identities = 45/121 (37%), Positives = 87/121 (71%), Gaps = 2/121 (1%) Frame = +1 Query: 127 IRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTKE--LIKVADFGLAREIISEPPYTEYV 300 ++ + +Q+F++L+++H G HRD+KP+NLL+ + ++K+ DFG A++++ P Y+ Sbjct: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Query: 301 STRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPN 480 +R+YRAPE++ ++ Y+S++D+W+ G ++AEL +P+FPG S D++ +I +LGTP Sbjct: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Query: 481 Q 483 + Sbjct: 278 R 278
>MK13_HUMAN (O15264) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 365 Score = 112 bits (281), Expect = 5e-25 Identities = 58/144 (40%), Positives = 89/144 (61%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M+ +L ++M G FSE +I+ +Q+ + L ++H G HRDLKP NL V + Sbjct: 104 YLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR +E T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 161 DCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF G D++ +I + G P Sbjct: 219 GKTLFKGKDYLDQLTQILKVTGVP 242
>MK12_RAT (Q63538) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 112 bits (281), Expect = 5e-25 Identities = 60/144 (41%), Positives = 90/144 (62%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M +L +LMK + SE I+ +Q+ + L ++H G HRDLKP NL V + Sbjct: 106 YLVMPFMGTDLGKLMKHE--TLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNE 163 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR+ SE T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 164 DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF G+ D++ +I + GTP Sbjct: 222 GKILFKGNDHLDQLKEIMKVTGTP 245
>MK12_HUMAN (P53778) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 112 bits (281), Expect = 5e-25 Identities = 60/144 (41%), Positives = 89/144 (61%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M +L +LMK + E I+ +Q+ + L ++H G HRDLKP NL V + Sbjct: 106 YLVMPFMGTDLGKLMKHE--KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE 163 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR+ SE T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 164 DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF GS D++ +I + GTP Sbjct: 222 GKTLFKGSDHLDQLKEIMKVTGTP 245
>MK13_RAT (Q9WTY9) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 112 bits (280), Expect = 7e-25 Identities = 57/144 (39%), Positives = 89/144 (61%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M+ +L ++M G FSE +++ +Q+ + L ++H G HRDLKP NL V + Sbjct: 104 YLVMPFMQTDLQKIM---GMEFSEEKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNE 160 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR +E T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 161 DCELKILDFGLARHTDAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF G D++ +I + G P Sbjct: 219 GKTLFKGKDYLDQLTQILKVTGVP 242
>MK13_MOUSE (Q9Z1B7) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 112 bits (280), Expect = 7e-25 Identities = 57/144 (39%), Positives = 89/144 (61%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M+ +L ++M G FSE +++ +Q+ + L ++H G HRDLKP NL V + Sbjct: 104 YLVMPFMQTDLQKIM---GMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNE 160 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR +E T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 161 DCELKILDFGLARHTDTE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF G D++ +I + G P Sbjct: 219 GKTLFKGKDYLDQLTQILKVTGVP 242
>BUR1_YEAST (P23293) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) (Suppressor of GPA1-Vall50 mutation protein 1) (Bypass UAS requirement protein 1) Length = 657 Score = 112 bits (280), Expect = 7e-25 Identities = 55/163 (33%), Positives = 90/163 (55%), Gaps = 14/163 (8%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + + YM +L ++ + +I+N Q+ + L+++H + HRD+K N+L+ Sbjct: 146 YMILPYMVADLSGVLHNPRINLEMCDIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDH 205 Query: 229 E-LIKVADFGLAREIISEPP-------------YTEYVSTRWYRAPEVLLQSSVYSSAVD 366 ++K+ADFGLAR PP YT V TRWYRAPE++L Y++AVD Sbjct: 206 NGVLKLADFGLARLYYGCPPNLKYPGGAGSGAKYTSVVVTRWYRAPELVLGDKQYTTAVD 265 Query: 367 MWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWA 495 +W +G + AE F +P+ G ++ D+ + I +LGTP + WA Sbjct: 266 IWGVGCVFAEFFEKKPILQGKTDIDQGHVIFKLLGTPTEEDWA 308
>MK14_XENLA (P47812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) Length = 361 Score = 112 bits (280), Expect = 7e-25 Identities = 58/153 (37%), Positives = 93/153 (60%), Gaps = 1/153 (0%) Frame = +1 Query: 22 RS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDL 201 +S E + ++ V M +L ++K + ++ ++ +Q+ + L ++H G HRDL Sbjct: 95 KSFEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSAGIIHRDL 152 Query: 202 KPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 KP NL V ++ +K+ DFGLAR E T YV+TRWYRAPE++L Y+ VD+W++ Sbjct: 153 KPSNLAVNEDCELKILDFGLARHTDEE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 210 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AEL + R LFPG+ D++ I ++GTP Sbjct: 211 GCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 243
>NLK_MOUSE (O54949) Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like| kinase) Length = 515 Score = 112 bits (279), Expect = 9e-25 Identities = 57/148 (38%), Positives = 94/148 (63%), Gaps = 3/148 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V E M+ +L++++ S +P S ++ + +Q+ + L ++H G HRD+KP NLLV Sbjct: 203 IYVVTELMQSDLHKIIVSP-QPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN 261 Query: 226 KE-LIKVADFGLAR--EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 ++K+ DFGLAR E+ T+ V T++YRAPE+L+ S YS+A+D+W++G I AE Sbjct: 262 SNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAE 321 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPN 480 L R LF S ++ I ++LGTP+ Sbjct: 322 LLGRRILFQAQSPIQQLDLITDLLGTPS 349
>NLK_HUMAN (Q9UBE8) Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like| kinase) (LAK1 protein) Length = 515 Score = 112 bits (279), Expect = 9e-25 Identities = 57/148 (38%), Positives = 94/148 (63%), Gaps = 3/148 (2%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V E M+ +L++++ S +P S ++ + +Q+ + L ++H G HRD+KP NLLV Sbjct: 203 IYVVTELMQSDLHKIIVSP-QPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN 261 Query: 226 KE-LIKVADFGLAR--EIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAE 396 ++K+ DFGLAR E+ T+ V T++YRAPE+L+ S YS+A+D+W++G I AE Sbjct: 262 SNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAE 321 Query: 397 LFSHRPLFPGSSEADEIYKICNILGTPN 480 L R LF S ++ I ++LGTP+ Sbjct: 322 LLGRRILFQAQSPIQQLDLITDLLGTPS 349
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 111 bits (278), Expect = 1e-24 Identities = 50/149 (33%), Positives = 95/149 (63%), Gaps = 5/149 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEI---RNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L V E++ LY++ + + + R + +Q+ +++ ++H G+ HRD+KP+N+ Sbjct: 105 LNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNM 164 Query: 217 LVTKE--LIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E ++K+ DFG A+++IS P Y+ +R+YRAPE++ S+ Y++ +DMW+ G ++ Sbjct: 165 LLDSETGVLKLCDFGSAKQLISGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGCVM 224 Query: 391 AELFSHRPLFPGSSEADEIYKICNILGTP 477 +EL + +FPG S D+I +I ++GTP Sbjct: 225 SELLLGQLIFPGDSGVDQIVEIVKVMGTP 253
>CD2L7_CAEEL (P46551) Putative cell division cycle 2-related protein kinase 7| (EC 2.7.11.22) Length = 730 Score = 111 bits (278), Expect = 1e-24 Identities = 59/151 (39%), Positives = 93/151 (61%), Gaps = 3/151 (1%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGK-PFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 + VFEY++ +L L++SK F++ +I + Q+ + L+++H G+ HRD+K N+LV Sbjct: 394 YLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVN 453 Query: 226 -KELIKVADFGLAREIISEPP-YTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAEL 399 K +K+AD GLAR E YT V T WYR PE+LL Y A+D+W+ G ++ EL Sbjct: 454 NKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGEL 513 Query: 400 FSHRPLFPGSSEADEIYKICNILGTPNQHTW 492 F+ +PLF G++E ++ I + G+PN W Sbjct: 514 FTRKPLFNGNNEFGQLELISKVCGSPNVDNW 544
>KSG9_ARATH (Q39012) Shaggy-related protein kinase iota (EC 2.7.11.1)| (ASK-iota) Length = 407 Score = 111 bits (278), Expect = 1e-24 Identities = 58/169 (34%), Positives = 102/169 (60%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMK---SKGKPFSETEIRNWCFQVFQALS 165 KHC S D LF V EY+ LY++++ S + ++ + +Q+F+ L+ Sbjct: 127 KHCFFSTTS---RDELFLNLVMEYVPETLYRVLRHYTSSNQRMPIFYVKLYTYQIFRGLA 183 Query: 166 HMHQ-RGYFHRDLKPENLLVTK--ELIKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H G HRD+KP+NLLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 184 YIHTVPGVCHRDVKPQNLLVDPLTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 243 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++++D+W+ G ++AEL +PLFPG + D++ +I +LGTP + Sbjct: 244 GATEYTASIDIWSAGCVLAELLLGQPLFPGENSVDQLVEIIKVLGTPTR 292
>BUR1_NEUCR (Q871M9) Serine/threonine-protein kinase bur-1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 545 Score = 110 bits (276), Expect = 2e-24 Identities = 53/165 (32%), Positives = 94/165 (56%), Gaps = 13/165 (7%) Frame = +1 Query: 43 MLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLV 222 +++ V YM+ +L L+ + F+E +++ + Q+ + L ++H HRD+K NLL+ Sbjct: 106 IVYMVTPYMDHDLSGLLDNPSVRFTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLI 165 Query: 223 T-KELIKVADFGLAREIISEPP------------YTEYVSTRWYRAPEVLLQSSVYSSAV 363 K ++++ADFGLAR + P YT V TRWYR PE+L+ Y++A+ Sbjct: 166 NNKGVLQIADFGLARHYEGDIPQPGKGSGEGKRDYTSLVVTRWYRPPELLMHLKRYTTAI 225 Query: 364 DMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWAG 498 DMW +G + AE+ +P+ G S+ ++ + ++ GTP++ T G Sbjct: 226 DMWGVGCVFAEMLEGKPVLQGESDLHQLELVWDLCGTPSEETMPG 270
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 110 bits (276), Expect = 2e-24 Identities = 54/145 (37%), Positives = 90/145 (62%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V M+ +L +++++ S+ ++ +Q+ + L ++H G HRDLKP N+ V Sbjct: 105 VYMVTHLMDADLNNIIRTQ--KLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVN 162 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++ +++ DFGLAR SE T YV+TRWYRAPE++L Y+ D+W++G I+AEL Sbjct: 163 EDCELRILDFGLARPAESE--MTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELL 220 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 + R LFPG+ ++ I +LGTP Sbjct: 221 TGRTLFPGTDHIHQLNLIMEVLGTP 245
>MK13_PANTR (Q9N272) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) Length = 365 Score = 110 bits (276), Expect = 2e-24 Identities = 57/144 (39%), Positives = 89/144 (61%), Gaps = 1/144 (0%) Frame = +1 Query: 49 FFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVTK 228 + V +M+ +L ++M + FSE +I+ +Q+ + L ++H G HRDLKP NL V + Sbjct: 104 YLVMXFMQTDLQKIMXME---FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 Query: 229 EL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFS 405 + +K+ DFGLAR +E T YV TRWYRAPEV+L Y+ VD+W++G I+AE+ + Sbjct: 161 DCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 Query: 406 HRPLFPGSSEADEIYKICNILGTP 477 + LF G D++ +I + G P Sbjct: 219 GKTLFKGKDYLDQLTQILKVTGVP 242
>MK14_RAT (P70618) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 110 bits (276), Expect = 2e-24 Identities = 58/153 (37%), Positives = 92/153 (60%), Gaps = 1/153 (0%) Frame = +1 Query: 22 RS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDL 201 RS E + ++ V M +L ++K + ++ ++ +Q+ + L ++H HRDL Sbjct: 93 RSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDL 150 Query: 202 KPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 KP NL V ++ +K+ DFGLAR E T YV+TRWYRAPE++L Y+ VD+W++ Sbjct: 151 KPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 208 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AEL + R LFPG+ D++ I ++GTP Sbjct: 209 GCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>MK14_MOUSE (P47811) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 110 bits (276), Expect = 2e-24 Identities = 58/153 (37%), Positives = 92/153 (60%), Gaps = 1/153 (0%) Frame = +1 Query: 22 RS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDL 201 RS E + ++ V M +L ++K + ++ ++ +Q+ + L ++H HRDL Sbjct: 93 RSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDL 150 Query: 202 KPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 KP NL V ++ +K+ DFGLAR E T YV+TRWYRAPE++L Y+ VD+W++ Sbjct: 151 KPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 208 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AEL + R LFPG+ D++ I ++GTP Sbjct: 209 GCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>MK14_HUMAN (Q16539) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting prote Length = 359 Score = 110 bits (276), Expect = 2e-24 Identities = 58/153 (37%), Positives = 92/153 (60%), Gaps = 1/153 (0%) Frame = +1 Query: 22 RS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDL 201 RS E + ++ V M +L ++K + ++ ++ +Q+ + L ++H HRDL Sbjct: 93 RSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDL 150 Query: 202 KPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 KP NL V ++ +K+ DFGLAR E T YV+TRWYRAPE++L Y+ VD+W++ Sbjct: 151 KPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 208 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AEL + R LFPG+ D++ I ++GTP Sbjct: 209 GCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Length = 359 Score = 110 bits (276), Expect = 2e-24 Identities = 58/153 (37%), Positives = 92/153 (60%), Gaps = 1/153 (0%) Frame = +1 Query: 22 RS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDL 201 RS E + ++ V M +L ++K + ++ ++ +Q+ + L ++H HRDL Sbjct: 93 RSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDL 150 Query: 202 KPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 KP NL V ++ +K+ DFGLAR E T YV+TRWYRAPE++L Y+ VD+W++ Sbjct: 151 KPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 208 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AEL + R LFPG+ D++ I ++GTP Sbjct: 209 GCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>KSG8_ARATH (Q96287) Shaggy-related protein kinase theta (EC 2.7.11.1)| (ASK-theta) Length = 472 Score = 110 bits (275), Expect = 2e-24 Identities = 57/152 (37%), Positives = 95/152 (62%), Gaps = 6/152 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEI---RNWCFQVFQALSHMHQR-GYFHRDLKPEN 213 L V EY+ +Y+ K K I + + +Q+ +AL+++H+ G HRD+KP+N Sbjct: 209 LNLVLEYVPETVYRASKHYTKMNQHMPIIFVQLYTYQICRALNYLHRVVGVCHRDIKPQN 268 Query: 214 LLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 LLV + +K+ DFG A+ ++ P Y+ +R+YRAPE++ ++ Y++A+DMW+ G + Sbjct: 269 LLVNPQTHQLKICDFGSAKMLVPGEPNISYICSRYYRAPELIFGATEYTNAIDMWSGGCV 328 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 +AEL +PLFPG S D++ +I ILGTP + Sbjct: 329 MAELLLGQPLFPGESGIDQLVEIIKILGTPTR 360
>MK14B_BRARE (Q9DGE1) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b) Length = 348 Score = 110 bits (274), Expect = 3e-24 Identities = 54/145 (37%), Positives = 91/145 (62%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V M +L ++K + ++ ++ +Q+ +AL ++H HRDLKP NL V Sbjct: 103 VYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRALKYIHSADIIHRDLKPSNLAVN 160 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++ +K+ DFGLAR +++ T YV+TRWYRAPE++L Y+ VD+W++G I+AEL Sbjct: 161 EDCELKILDFGLAR--LTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELL 218 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 + R LFPG+ +++ +I + GTP Sbjct: 219 TGRTLFPGTDHINQLQQIMRLTGTP 243
>MK14A_DROME (O62618) Mitogen-activated protein kinase 14A (EC 2.7.11.24) (MAP| kinase p38a) (p38 MAPK) (Dp38) (D-p38a) Length = 366 Score = 110 bits (274), Expect = 3e-24 Identities = 54/145 (37%), Positives = 89/145 (61%), Gaps = 1/145 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V M+ +L +++ + S+ ++ +Q+ + L ++H G HRDLKP N+ V Sbjct: 106 VYLVTHLMDADLNNIIRMQH--LSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVN 163 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 ++ +++ DFGLAR +E T YV+TRWYRAPE++L Y VD+W++G I+AEL Sbjct: 164 EDCELRILDFGLARP--TENEMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELI 221 Query: 403 SHRPLFPGSSEADEIYKICNILGTP 477 + R LFPG+ ++ I +LGTP Sbjct: 222 TRRTLFPGTDHIHQLNLIMEMLGTP 246
>KSG5_ARATH (Q8VZD5) Shaggy-related protein kinase epsilon (EC 2.7.11.1)| (ASK-epsilon) Length = 410 Score = 109 bits (273), Expect = 4e-24 Identities = 59/169 (34%), Positives = 100/169 (59%), Gaps = 8/169 (4%) Frame = +1 Query: 1 KHCEAQGRS*XENDMLFF--VFEYMECNLYQLMKSKGKPFSETEI---RNWCFQVFQALS 165 KHC S E D L+ V EY+ +Y++ K + I + + +Q+ +AL+ Sbjct: 131 KHCFF---STTEKDELYLNLVLEYVPETVYRVSKHYSRANQRMPIIYVKLYTYQICRALA 187 Query: 166 HMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLL 336 ++H G HRD+KP+NLLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ Sbjct: 188 YIHGGVGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIF 247 Query: 337 QSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 ++ Y++ +D+W+ G ++AEL +PLFPG S D++ +I +LGTP + Sbjct: 248 GATEYTTTIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR 296
>MK14_PANTR (Q95NE7) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) Length = 359 Score = 109 bits (273), Expect = 4e-24 Identities = 57/153 (37%), Positives = 92/153 (60%), Gaps = 1/153 (0%) Frame = +1 Query: 22 RS*XENDMLFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDL 201 RS E + ++ V M +L ++K + ++ ++ +Q+ + L ++H HRDL Sbjct: 93 RSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDL 150 Query: 202 KPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAM 378 KP NL V ++ +K+ DFGLAR E T YV+TRWYRAPE++L Y+ VD+W++ Sbjct: 151 KPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 208 Query: 379 GAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 G I+AEL + R LFPG+ +++ +I + GTP Sbjct: 209 GCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 241
>KSG10_ARATH (Q39019) Shaggy-related protein kinase kappa (EC 2.7.11.1)| (ASK-kappa) (AtK-1) Length = 421 Score = 109 bits (272), Expect = 6e-24 Identities = 48/122 (39%), Positives = 83/122 (68%), Gaps = 3/122 (2%) Frame = +1 Query: 127 IRNWCFQVFQALSHMHQR-GYFHRDLKPENLLVTKEL--IKVADFGLAREIISEPPYTEY 297 ++ + +Q+ +AL+++H G HRD+KP+NLLV +K+ DFG A+ ++ P Y Sbjct: 184 VKLYTYQICRALAYIHNSFGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPNVSY 243 Query: 298 VSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTP 477 + +R+YRAPE++ +S Y++A+D+W+ G ++AEL +PLFPG S D++ +I +LGTP Sbjct: 244 ICSRYYRAPELIFGASEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTP 303 Query: 478 NQ 483 + Sbjct: 304 TR 305
>KSGT_BRANA (O04160) Shaggy-related protein kinase theta (EC 2.7.11.1)| (ASK-theta) Length = 468 Score = 109 bits (272), Expect = 6e-24 Identities = 56/152 (36%), Positives = 95/152 (62%), Gaps = 6/152 (3%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEI---RNWCFQVFQALSHMHQR-GYFHRDLKPEN 213 L V E++ +Y+ +K K I + + +Q+ +AL+++H+ G HRD+KP+N Sbjct: 205 LNLVLEFVPETVYRALKHYTKMNQHMPIILVQLYTYQICRALNYLHRVVGVCHRDIKPQN 264 Query: 214 LLVTKEL--IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAI 387 LLV +K+ DFG A+ ++ P Y+ +R+YRAPE++ ++ Y++A+DMW+ G + Sbjct: 265 LLVNTHTHQLKICDFGSAKMLVPGEPNISYICSRYYRAPELIFGATEYTNAIDMWSGGCV 324 Query: 388 IAELFSHRPLFPGSSEADEIYKICNILGTPNQ 483 +AEL +PLFPG S D++ +I ILGTP + Sbjct: 325 MAELLLGQPLFPGESGIDQLVEIIKILGTPTR 356
>MK11_HUMAN (Q15759) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase 2) Length = 372 Score = 109 bits (272), Expect = 6e-24 Identities = 51/119 (42%), Positives = 78/119 (65%), Gaps = 1/119 (0%) Frame = +1 Query: 142 FQVFQALSHMHQRGYFHRDLKPENLLVTKEL-IKVADFGLAREIISEPPYTEYVSTRWYR 318 +Q+ + L ++H G HRDLKP N+ V ++ +++ DFGLAR+ E T YV+TRWYR Sbjct: 140 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYR 197 Query: 319 APEVLLQSSVYSSAVDMWAMGAIIAELFSHRPLFPGSSEADEIYKICNILGTPNQHTWA 495 APE++L Y+ VD+W++G I+AEL + LFPGS D++ +I ++GTP+ A Sbjct: 198 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 256
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 108 bits (271), Expect = 7e-24 Identities = 70/204 (34%), Positives = 98/204 (48%), Gaps = 53/204 (25%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSK---GKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENL 216 L+ VFE++ +L + M + G P I+++ FQ+ Q L+ H HRDLKP+NL Sbjct: 76 LYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 217 LVTKE-LIKVADFGLAREI-ISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAII 390 L+ E IK+ADFGLAR + YT V T WYRAPE+LL YS+AVD+W++G I Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 391 AEL------------------------------------------------FSHRPLFPG 426 AE+ + R LFPG Sbjct: 194 AEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPG 253 Query: 427 SSEADEIYKICNILGTPNQHTWAG 498 SE D++++I LGTP++ W G Sbjct: 254 DSEIDQLFRIFRTLGTPDEVVWPG 277
>MK08A_CYPCA (Q90327) Mitogen-activated protein kinase 8A (EC 2.7.11.24)| (Stress-activated protein kinase JNKa) (c-Jun N-terminal kinase A) Length = 427 Score = 108 bits (270), Expect = 9e-24 Identities = 57/147 (38%), Positives = 86/147 (58%), Gaps = 1/147 (0%) Frame = +1 Query: 46 LFFVFEYMECNLYQLMKSKGKPFSETEIRNWCFQVFQALSHMHQRGYFHRDLKPENLLVT 225 ++ V E M+ NL Q+++ + + +Q+ + H+H G HRDLKP N++V Sbjct: 104 VYLVMELMDANLCQVIQME---LDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 160 Query: 226 KEL-IKVADFGLAREIISEPPYTEYVSTRWYRAPEVLLQSSVYSSAVDMWAMGAIIAELF 402 + +K+ DFGLAR + T YV TR+YRAPEV+L Y + VD+W++G I+AE+ Sbjct: 161 SDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMG-YQANVDIWSVGCILAEMV 219 Query: 403 SHRPLFPGSSEADEIYKICNILGTPNQ 483 H+ LFPG D+ K+ LGTP Q Sbjct: 220 RHKILFPGRDYIDQWNKVIEQLGTPTQ 246 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 74,685,581 Number of Sequences: 219361 Number of extensions: 1455908 Number of successful extensions: 7731 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5758 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5996 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4200495993 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
