>ASM_HUMAN (P17405) Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12)|
           (Acid sphingomyelinase) (aSMase)
          Length = 629

 Score = 39.7 bits (91), Expect = 0.007
 Identities = 32/94 (34%), Positives = 40/94 (42%), Gaps = 1/94 (1%)
 Frame = +2

Query: 65  QLSWLNDVLQDASDRRQNVVLCSHLPMDPGAVYPAALMWNYDEVMAIVRRYNCVRACFAG 244
           QL WL   LQ A DR   V +  H+P  PG     +  WNY  ++A  R  N + A F G
Sbjct: 402 QLQWLVGELQAAEDRGDKVHIIGHIP--PGHCL-KSWSWNYYRIVA--RYENTLAAQFFG 456

Query: 245 HDHKGGYSV-DSHGVHHRTLEAALECPPGTSAFG 343
           H H   + V        R L  A   P  T+  G
Sbjct: 457 HTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIG 490

>ASM2_CAEEL (Q23498) Sphingomyelin phosphodiesterase 2 precursor (EC 3.1.4.12)|
           (Acid sphingomyelinase 2)
          Length = 618

 Score = 38.1 bits (87), Expect = 0.020
 Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
 Frame = +2

Query: 68  LSWLNDVLQDASDRRQNVVLCSHLPMDPGAVY-PAALMWNYDEVMAIVRRY-NCVRACFA 241
           L WL + LQD+ ++ + V + SH+P  PG  Y      WN+ E   IV+RY N +   F 
Sbjct: 405 LEWLIEELQDSENKGELVHIISHIP--PGDNYCLKGWSWNFFE---IVKRYENTIAQMFY 459

Query: 242 GHDHKGGYSV 271
           GH H   + V
Sbjct: 460 GHTHYDQFMV 469

>ASM_MOUSE (Q04519) Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12)|
           (Acid sphingomyelinase) (aSMase)
          Length = 627

 Score = 36.2 bits (82), Expect = 0.074
 Identities = 23/69 (33%), Positives = 34/69 (49%)
 Frame = +2

Query: 65  QLSWLNDVLQDASDRRQNVVLCSHLPMDPGAVYPAALMWNYDEVMAIVRRYNCVRACFAG 244
           QL WL + LQ A +R   V +  H+P  PG     +  WNY +++A  R  N +   F G
Sbjct: 400 QLQWLVEELQAAENRGDKVHIIGHIP--PGHCL-KSWSWNYYKIIA--RYENTLAGQFFG 454

Query: 245 HDHKGGYSV 271
           H H   + +
Sbjct: 455 HTHVDEFEI 463

>ASM1_CAEEL (Q10916) Sphingomyelin phosphodiesterase 1 precursor (EC 3.1.4.12)|
           (Acid sphingomyelinase 1)
          Length = 564

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/109 (22%), Positives = 44/109 (40%), Gaps = 3/109 (2%)
 Frame = +2

Query: 17  DVDRRFVKFNGAVGKEQLSWLNDVLQDASDRRQNVVLCSHLPMDPGAVYPAALMWNYDEV 196
           +V   F+  N +     +SW    L ++  + + V + +H+P            W ++  
Sbjct: 342 EVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSECLEG---WAFNYY 398

Query: 197 MAIVRRYNCVRACFAGHDHKGGYSV---DSHGVHHRTLEAALECPPGTS 334
             I R  + + A F GHDH   ++V   D H V  + +      P  T+
Sbjct: 399 RVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTT 447

>ASM3A_RAT (Q641Z7) Acid sphingomyelinase-like phosphodiesterase 3a precursor|
           (EC 3.1.4.-) (ASM-like phosphodiesterase 3a)
          Length = 445

 Score = 34.3 bits (77), Expect = 0.28
 Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
 Frame = +2

Query: 65  QLSWLNDVLQDASDRRQNVVLCSHLPMD--PGAVYPAALMWNYDE-VMAIVRRYNCVRA- 232
           Q  WL + L  +   ++ V + +H+P+   P A    A+   Y+E ++ I RRY+ V A 
Sbjct: 226 QFEWLENTLNSSLRNKEKVYVIAHVPVGYLPYATKTPAMRQYYNEKLVDIFRRYSSVIAG 285

Query: 233 CFAGHDHKGGYSV 271
            F GH H+    V
Sbjct: 286 QFYGHTHRDSLMV 298

>ASM3A_MOUSE (P70158) Acid sphingomyelinase-like phosphodiesterase 3a precursor|
           (EC 3.1.4.-) (ASM-like phosphodiesterase 3a)
          Length = 445

 Score = 32.7 bits (73), Expect = 0.82
 Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 4/73 (5%)
 Frame = +2

Query: 65  QLSWLNDVLQDASDRRQNVVLCSHLPMD--PGAVYPAALMWNYDE-VMAIVRRYNCVRA- 232
           Q  WL + L  +   ++ V   +H+P+   P A    A+   Y+E ++ I RRY+ V A 
Sbjct: 226 QFEWLENTLNSSLWNKEKVYXIAHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAG 285

Query: 233 CFAGHDHKGGYSV 271
            F GH H+    V
Sbjct: 286 QFYGHTHRDSLMV 298

>ASM3A_HUMAN (Q92484) Acid sphingomyelinase-like phosphodiesterase 3a precursor|
           (EC 3.1.4.-) (ASM-like phosphodiesterase 3a)
          Length = 453

 Score = 31.2 bits (69), Expect = 2.4
 Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
 Frame = +2

Query: 65  QLSWLNDVLQDASDRRQNVVLCSHLPMD--PGAVYPAALMWNYDE-VMAIVRRYNCVRA- 232
           Q  WL   L ++   ++ V + +H+P+   P +    A+   Y+E ++ I ++Y+ V A 
Sbjct: 229 QFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAG 288

Query: 233 CFAGHDHKGGYSV 271
            F GH H+    V
Sbjct: 289 QFYGHTHRDSIMV 301

>ASM3_CAEEL (Q9UAY4) Putative sphingomyelin phosphodiesterase asm-3 precursor|
           (EC 3.1.4.12)
          Length = 589

 Score = 30.8 bits (68), Expect = 3.1
 Identities = 22/63 (34%), Positives = 29/63 (46%), Gaps = 1/63 (1%)
 Frame = +2

Query: 68  LSWLNDVLQDASDRRQNVVLCSHLPMDPGAVYPAALMWNYDEVMAIVRRY-NCVRACFAG 244
           L WL + LQDA +    V + +H+P   G       + NY     I+ RY N V   F G
Sbjct: 342 LQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYAL-NY---YKIINRYANTVVGQFFG 397

Query: 245 HDH 253
           H H
Sbjct: 398 HTH 400

>ASM3B_HUMAN (Q92485) Acid sphingomyelinase-like phosphodiesterase 3b precursor|
           (EC 3.1.4.-) (ASM-like phosphodiesterase 3b)
          Length = 455

 Score = 30.8 bits (68), Expect = 3.1
 Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 8/83 (9%)
 Frame = +2

Query: 62  EQLSWLNDVLQDASDRRQNVVLCSHLPMDPG----AVYPAALMWNYDE-VMAIVRRYNCV 226
           +Q  WL DVL DAS     V +  H+P  PG        A     ++E  + +VR+++ V
Sbjct: 212 QQFQWLEDVLTDASKAGDMVYIVGHVP--PGFFEKTQNKAWFREGFNEKYLKVVRKHHRV 269

Query: 227 RA-CFAGHDHKGGYSV--DSHGV 286
            A  F GH H   + +  D  GV
Sbjct: 270 IAGQFFGHHHTDSFRMLYDDAGV 292

>ASM3B_MOUSE (P58242) Acid sphingomyelinase-like phosphodiesterase 3b precursor|
           (EC 3.1.4.-) (ASM-like phosphodiesterase 3b)
          Length = 456

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 20/74 (27%), Positives = 31/74 (41%), Gaps = 6/74 (8%)
 Frame = +2

Query: 62  EQLSWLNDVLQDASDRRQNVVLCSHLPMDPGAVYPA------ALMWNYDEVMAIVRRYNC 223
           EQ  WL DVL +AS   + V +  H+P  PG              +N + +  I + +  
Sbjct: 212 EQFRWLGDVLSNASRDGEMVYVIGHVP--PGFFEKTQNKAWFRESFNEEYLKVIQKHHRV 269

Query: 224 VRACFAGHDHKGGY 265
           +   F GH H   +
Sbjct: 270 IAGQFFGHHHTDSF 283

>Y1707_PASMU (Q9CKB7) Hypothetical protein PM1707 precursor|
          Length = 380

 Score = 30.0 bits (66), Expect = 5.3
 Identities = 28/123 (22%), Positives = 55/123 (44%), Gaps = 9/123 (7%)
 Frame = +2

Query: 47  GAVGKEQLSW--LNDVLQDASDRRQNVVLCS-------HLPMDPGAVYPAALMWNYDEVM 199
           G +GK+ ++W  L D+       +Q+ +          H  +  GA +P AL  NY++ +
Sbjct: 244 GTIGKDGVTWKKLGDLPAPTGYDKQDGIAGGMGGYTNGHYIVTGGANFPGALA-NYEKGI 302

Query: 200 AIVRRYNCVRACFAGHDHKGGYSVDSHGVHHRTLEAALECPPGTSAFGHIEAYPDKLLLV 379
               R   ++  +    HK  Y++D    + + +       P T  +G   +Y +K+LL+
Sbjct: 303 MDAHRTGGLKKTY----HKAVYALDGKTGNWKIVGEL----PATIGYGLAVSYNNKVLLI 354

Query: 380 GSD 388
           G +
Sbjct: 355 GGE 357

>PPN1_ASHGO (Q756F2) Endopolyphosphatase (EC 3.6.1.10)|
          Length = 594

 Score = 30.0 bits (66), Expect = 5.3
 Identities = 16/49 (32%), Positives = 21/49 (42%), Gaps = 4/49 (8%)
 Frame = +2

Query: 56  GKEQLSWLNDVLQDASDRRQNVVLCSHLPMDP----GAVYPAALMWNYD 190
           G   L WL  VL++   R   V L  H+P  P    G+ Y     W Y+
Sbjct: 275 GHALLLWLGSVLEEMRARNMKVWLSGHVPPIPKNFEGSCYNKLAWWTYE 323

>PPA5_RAT (P29288) Tartrate-resistant acid phosphatase type 5 precursor (EC|
           3.1.3.2) (TR-AP) (Tartrate-resistant acid ATPase)
           (TrATPase) (Acid phosphatase 5, tartrate resistant)
          Length = 327

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 2/80 (2%)
 Frame = +2

Query: 53  VGKEQLSWLNDVLQDASDRRQNVVLCSHLPMDPGAVY--PAALMWNYDEVMAIVRRYNCV 226
           V + QLSWL   L  A+ +   V++  H P+   A +     L+ N   ++A       V
Sbjct: 182 VARTQLSWLKKQL--AAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYG----V 235

Query: 227 RACFAGHDHKGGYSVDSHGV 286
            A   GHDH   Y  D +GV
Sbjct: 236 TAYLCGHDHNLQYLQDENGV 255

>PPA5_MOUSE (Q05117) Tartrate-resistant acid phosphatase type 5 precursor (EC|
           3.1.3.2) (TR-AP) (Tartrate-resistant acid ATPase)
           (TrATPase) (Acid phosphatase 5, tartrate resistant)
          Length = 327

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 2/80 (2%)
 Frame = +2

Query: 53  VGKEQLSWLNDVLQDASDRRQNVVLCSHLPMDPGAVY--PAALMWNYDEVMAIVRRYNCV 226
           V + QLSWL   L  A+ +   V++  H P+   A +     L+ N   ++A       V
Sbjct: 182 VARTQLSWLKKQL--AAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLATYG----V 235

Query: 227 RACFAGHDHKGGYSVDSHGV 286
            A   GHDH   Y  D +GV
Sbjct: 236 TAYLCGHDHNLQYLQDENGV 255

>JAG2_RAT (P97607) Jagged-2 (Jagged2) (Fragment)|
          Length = 1202

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 17/45 (37%), Positives = 20/45 (44%), Gaps = 17/45 (37%)
 Frame = +1

Query: 34  CEVQWCGW-------QGAAVLAQ*CPPG----------CIGPPAE 117
           C   WCGW       Q +A+ AQ CPPG          C+ PP E
Sbjct: 856 CSKVWCGWKPCLLSPQPSALSAQ-CPPGQQCREKAMGQCLQPPCE 899

>ERG28_SCHPO (O74820) Ergosterol biosynthetic protein 28|
          Length = 136

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 16/30 (53%), Positives = 17/30 (56%)
 Frame = +3

Query: 150 LAQCTQQLLCGTMMR*WLLFDGTTVLGPAL 239
           L QCT  L C   +  WLLF  TT LGP L
Sbjct: 82  LCQCTYYLACFHFLSEWLLF-RTTNLGPGL 110


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,145,197
Number of Sequences: 219361
Number of extensions: 2061819
Number of successful extensions: 5914
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 5597
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5908
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5253413348
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)