Clone Information

BLAST Search Result

Clone Name	bags25n22
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	91	7e-19
2	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	91	7e-19
3	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	87	7e-18
4	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	84	8e-17
5	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	81	5e-16
6	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	80	9e-16
7	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	80	2e-15
8	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	78	5e-15
9	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	77	1e-14
10	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	76	2e-14
11	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	76	2e-14
12	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	75	4e-14
13	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	73	1e-13
14	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	73	1e-13
15	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	70	1e-12
16	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	69	4e-12
17	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	68	6e-12
18	RCC2_MOUSE (Q8BK67) Protein RCC2	67	8e-12
19	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	67	1e-11
20	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	67	1e-11
21	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	66	2e-11
22	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	65	5e-11
23	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	61	7e-10
24	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	60	1e-09
25	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	60	2e-09
26	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	60	2e-09
27	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	59	4e-09
28	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	58	6e-09
29	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	56	2e-08
30	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	56	2e-08
31	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	53	2e-07
32	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	53	2e-07
33	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	53	2e-07
34	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	53	2e-07
35	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	52	5e-07
36	RCC1_XENLA (P25183) Regulator of chromosome condensation	52	5e-07
37	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	51	6e-07
38	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	51	8e-07
39	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	51	8e-07
40	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	50	1e-06
41	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	49	2e-06
42	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	47	1e-05
43	RCC1_CANAL (P52499) Protein RCC1	42	5e-04
44	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	38	0.005
45	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	35	0.034
46	POF9_SCHPO (O74381) F-box protein pof9	32	0.49
47	RSP6_CHLRE (Q01657) Flagellar radial spoke protein 6	31	0.83
48	LEU2_RHOPA (Q6ND69) 3-isopropylmalate dehydratase large subunit ...	29	2.4
49	LEU2_NITWN (Q3SNV3) 3-isopropylmalate dehydratase large subunit ...	29	2.4
50	LEU22_BRAJA (Q89X34) 3-isopropylmalate dehydratase large subunit...	29	2.4
51	YB9W_YEAST (P38352) F-box protein YBR280C	29	3.2
52	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	29	3.2
53	PPA5_RAT (P29288) Tartrate-resistant acid phosphatase type 5 pre...	29	3.2
54	PPA5_RABIT (O97860) Tartrate-resistant acid phosphatase type 5 p...	28	4.1
55	PPA5_HUMAN (P13686) Tartrate-resistant acid phosphatase type 5 p...	28	4.1
56	PPA5_MOUSE (Q05117) Tartrate-resistant acid phosphatase type 5 p...	28	4.1
57	LEU2_PSEHT (Q3IJS4) 3-isopropylmalate dehydratase large subunit ...	28	5.4
58	TMPS9_HUMAN (Q7Z410) Transmembrane protease, serine 9 (EC 3.4.21...	28	5.4
59	HD_FUGRU (P51112) Huntingtin (Huntington disease protein homolog...	28	7.0
60	SYFB_METJA (Q58508) Phenylalanyl-tRNA synthetase beta chain (EC ...	28	7.0
61	PCNT_HUMAN (O95613) Pericentrin (Pericentrin B) (Kendrin)	27	9.2
62	TRA1_YEAST (P38811) Transcription-associated protein 1 (p400 kDa...	27	9.2

>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score = 90.9 bits (224), Expect = 7e-19
 Identities = 46/114 (40%), Positives = 67/114 (58%)
 Frame = +1

Query: 37   GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            G+  + CGA  + A ++    V++WG GD+ RLGHG+   V  PQ V+ L+G K   +A 
Sbjct: 3207 GVCQIECGAQFSLALTKSG-VVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAV 3265

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
               HCLAVT +G+V +WG N +GQ G GTT  +  P  +Q  EG  +  +A G+
Sbjct: 3266 GALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGS 3319



 Score = 90.5 bits (223), Expect = 9e-19
 Identities = 46/114 (40%), Positives = 64/114 (56%)
 Frame = +1

Query: 37   GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            G+  V CG+  + A ++    VY+WG GD+ RLGHG+   V  P+ V+ LQG K   +A 
Sbjct: 4200 GVVKVECGSQFSVALTKSG-AVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIAT 4258

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
               HC+  T  GEV +WG N  GQLG GTT     P+ + A +G  V  +A G+
Sbjct: 4259 GSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGS 4312



 Score = 83.6 bits (205), Expect = 1e-16
 Identities = 42/111 (37%), Positives = 67/111 (60%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            +V  G  H  A S  E +VYSWG  + G+LGHGN +    P+ +++L+GI+   +A   +
Sbjct: 4045 AVNSGGKHCLALSS-EGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGA 4103

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H   VT AG++ +WG+ + G+LG   +ED L P+ ++A +G  V  IA G+
Sbjct: 4104 HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGS 4154



 Score = 82.0 bits (201), Expect = 3e-16
 Identities = 41/116 (35%), Positives = 68/116 (58%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
           +  + CG+ ++ A +  E ++Y+WG G++GRLGHG+S D   P  V  L+G+K   +AC 
Sbjct: 554 VVHIACGSTYSAAITA-EGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACG 612

Query: 217 -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
             D+  LAVT  G+V SWG    G+LG G ++    P+ I+  + + V  +  G++
Sbjct: 613 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQ 668



 Score = 81.3 bits (199), Expect = 5e-16
 Identities = 44/116 (37%), Positives = 65/116 (56%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
            I  +  G+ H+   +    ++Y+WG G++GRLGHG++T    P+ VK L G +  Q+AC 
Sbjct: 3102 IRDIAYGSSHSAPLTSSG-ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3160

Query: 217  -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
              D+  LA+T  G V SWG    G+LG G +E   +PQ I+   G  V  I  GA+
Sbjct: 3161 SRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ 3216



 Score = 80.5 bits (197), Expect = 9e-16
 Identities = 41/114 (35%), Positives = 64/114 (56%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40  ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           +  V CG+ D  T    +  QV+SWG GD+G+LG G S    TP+ ++ LQ +   ++ C
Sbjct: 606 VIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRC 665

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                +A+T  G+V SWG+  N +LG GT E    P+ ++  +G  V  +AAG+
Sbjct: 666 GSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGS 719



 Score = 79.7 bits (195), Expect = 2e-15
 Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 4/98 (4%)
 Frame = +1

Query: 97  QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQ----LACXDSHCLAVTMAGEVLS 264
           +VYSWG GD GRLGHG++  +  P+ + A  G +  +    +AC  ++  A+T  GE+ +
Sbjct: 516 EVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYT 575

Query: 265 WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
           WGR   G+LG G++ED  +P  +   +G+ V  +A G+
Sbjct: 576 WGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGS 613



 Score = 74.3 bits (181), Expect = 7e-14
 Identities = 41/114 (35%), Positives = 58/114 (50%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40   ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            +  V CG+ D  T    DE  V+SWG GDFG+LG G S     PQ ++ L G    Q+ C
Sbjct: 3154 VIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIEC 3213

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                 LA+T +G V +WG+    +LG G+      PQ ++   G  +  +A GA
Sbjct: 3214 GAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGA 3267



 Score = 72.8 bits (177), Expect = 2e-13
 Identities = 36/114 (31%), Positives = 60/114 (52%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40   ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            +  + CG+ D  T    D+  V+SWG GD+G+LG G S     P  + +L G+   ++ C
Sbjct: 4147 VIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVEC 4206

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                 +A+T +G V +WG+    +LG G+ +    P+ +Q  +G  V  IA G+
Sbjct: 4207 GSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGS 4260



 Score = 70.5 bits (171), Expect = 9e-13
 Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
            +  V  G  H+   +     +Y+WG G +GRLGH +S D   P+ V+ALQG +   +AC 
Sbjct: 4095 VVDVAAGGAHSACVTA-AGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACG 4153

Query: 217  -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
              D+  L +T    V SWG    G+LG G ++   +P  I +  G+ V  +  G++
Sbjct: 4154 SGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQ 4209



 Score = 70.5 bits (171), Expect = 9e-13
 Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 2/110 (1%)
 Frame = +1

Query: 52   ICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS-- 225
            + G + T      + ++Y+ G+G  GRLG G +  V TP  ++++Q +  K++A      
Sbjct: 3992 LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK 4051

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
            HCLA++  GEV SWG  ++G+LG G       P+ I++  GI V  +AAG
Sbjct: 4052 HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG 4101



 Score = 70.1 bits (170), Expect = 1e-12
 Identities = 37/111 (33%), Positives = 62/111 (55%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            +V  G  H TA + D  +V+SWG GD G+LGH +  +   P+ ++AL+  + + +A   S
Sbjct: 3052 AVHSGGRHATALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSS 3110

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H   +T +GE+ +WG  + G+LG G     L P+ ++   G  V  +A G+
Sbjct: 3111 HSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3161



 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 40/99 (40%), Positives = 53/99 (53%), Gaps = 4/99 (4%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG+  + A ++D  QVYSWG GD  RLGHG    V  P+ ++ LQG K   +A  
Sbjct: 660 VIKVRCGSQFSIALTKDG-QVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAG 718

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQ----LGLGTTEDSLLP 324
            +HCL +T   EV SWG N   Q    LG+   E +  P
Sbjct: 719 STHCLVLTEDSEVHSWGSNDQCQHFDTLGVTKPEPTAFP 757



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 27/93 (29%), Positives = 46/93 (49%)
 Frame = +1

Query: 100  VYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQ 279
            +Y WG    G+LG      V  P P +AL  ++  QL   +    AVT  G++ + G   
Sbjct: 3956 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4015

Query: 280  NGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
             G+LG+G TE    P  +++ + + +K +A  +
Sbjct: 4016 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS 4048



 Score = 51.2 bits (121), Expect = 6e-07
 Identities = 26/72 (36%), Positives = 40/72 (55%)
 Frame = +1

Query: 22   GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKX 201
            G     + ++  G+ H    +ED  +VY+WG  D G+LG G +  +  P+ V ALQG K 
Sbjct: 4247 GLQGKKVIAIATGSLHCVCCTEDG-EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKV 4305

Query: 202  KQLACXDSHCLA 237
             ++AC  +H LA
Sbjct: 4306 NRVACGSAHTLA 4317



 Score = 50.8 bits (120), Expect = 8e-07
 Identities = 35/99 (35%), Positives = 53/99 (53%), Gaps = 3/99 (3%)
 Frame = +1

Query: 91   EHQVYSWGWGDFGRLGHG-NSTDVFTPQPVKALQGIKXKQLACXDS--HCLAVTMAGEVL 261
            E +VYS G    GRLG G +S  V  P+ + AL     K++A      H  A+T+ G+V 
Sbjct: 3011 EGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3070

Query: 262  SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            SWG   +G+LG  +  +   P+ IQA +   ++ IA G+
Sbjct: 3071 SWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGS 3109



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 29/74 (39%), Positives = 39/74 (52%)
 Frame = +1

Query: 22   GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKX 201
            G     I  V  GA H  A + D  QVY+WG  D G+ G+G +T    P  V+ L+G K 
Sbjct: 3254 GLRGKKIVHVAVGALHCLAVT-DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKI 3312

Query: 202  KQLACXDSHCLAVT 243
             ++AC  SH +A T
Sbjct: 3313 TRVACGSSHSVAWT 3326



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 1/92 (1%)
 Frame = +1

Query: 97   QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
            +V+ WG  D  +LG    + +  P   + L  +   Q+A       AVT+ G+V S G  
Sbjct: 2961 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEA 3020

Query: 277  QNGQLGLGTTEDSL-LPQTIQAFEGISVKMIA 369
             NG+LGLG +  ++ +P+ I A     VK +A
Sbjct: 3021 TNGRLGLGMSSGTVPIPRQITALSSYVVKKVA 3052



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 25/69 (36%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
 Frame = +1

Query: 148 STDVFTPQPVKALQGIKXKQLACXDS--HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL 321
           ++D+  PQ V+ L      ++A      H LA+   GEV SWG    G+LG G T     
Sbjct: 479 NSDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEE 538

Query: 322 PQTIQAFEG 348
           P+ I AF G
Sbjct: 539 PKVISAFSG 547

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score = 90.9 bits (224), Expect = 7e-19
 Identities = 46/114 (40%), Positives = 67/114 (58%)
 Frame = +1

Query: 37   GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            G+  + CGA  + A ++    V++WG GD+ RLGHG+   V  PQ V+ L+G K   +A 
Sbjct: 3206 GVCQIECGAQFSLALTKSG-VVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAV 3264

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
               HCLAVT +G+V +WG N +GQ G GTT  +  P  +Q  EG  +  +A G+
Sbjct: 3265 GALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGS 3318



 Score = 90.5 bits (223), Expect = 9e-19
 Identities = 46/114 (40%), Positives = 64/114 (56%)
 Frame = +1

Query: 37   GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            G+  V CG+  + A ++    VY+WG GD+ RLGHG+   V  P+ V+ LQG K   +A 
Sbjct: 4198 GVVKVECGSQFSVALTKSG-AVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIAT 4256

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
               HC+  T  GEV +WG N  GQLG GTT     P+ + A +G  V  +A G+
Sbjct: 4257 GSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGS 4310



 Score = 87.4 bits (215), Expect = 7e-18
 Identities = 46/116 (39%), Positives = 67/116 (57%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
            I  + CG+ H+ A +    ++Y+WG G++GRLGHG++T    P+ VK L G +  Q+AC 
Sbjct: 3101 IRDIACGSSHSAALTSSG-ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3159

Query: 217  -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
              D+  LA+T  G V SWG    G+LG G +E   +PQ I+   G  V  I  GA+
Sbjct: 3160 SRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ 3215



 Score = 84.0 bits (206), Expect = 8e-17
 Identities = 42/111 (37%), Positives = 67/111 (60%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            +V  G  H  A S  E +VYSWG  + G+LGHGN +    P+ +++L+GI+   +A   +
Sbjct: 4043 AVNSGGKHCLALSS-EGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGA 4101

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H   VT AG++ +WG+ + G+LG   +ED L P+ ++A +G  V  IA G+
Sbjct: 4102 HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGS 4152



 Score = 82.4 bits (202), Expect = 2e-16
 Identities = 41/116 (35%), Positives = 68/116 (58%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
           +  + CG+ ++ A +  E ++Y+WG G++GRLGHG+S D   P  V  L+G+K   +AC 
Sbjct: 553 VVHIACGSTYSAAITA-EGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACG 611

Query: 217 -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
             D+  LAVT  G+V SWG    G+LG G ++    P+ I+  + + V  +  G++
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQ 667



 Score = 80.9 bits (198), Expect = 7e-16
 Identities = 41/114 (35%), Positives = 64/114 (56%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40  ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           +  V CG+ D  T    +  QV+SWG GD+G+LG G S    TP+ ++ LQ +   ++ C
Sbjct: 605 VIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRC 664

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                +A+T  G+V SWG+  N +LG GT E    P+ ++  +G  V  +AAG+
Sbjct: 665 GSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGS 718



 Score = 79.7 bits (195), Expect = 2e-15
 Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 4/98 (4%)
 Frame = +1

Query: 97  QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQ----LACXDSHCLAVTMAGEVLS 264
           +VYSWG GD GRLGHG++  +  P+ + A  G +  +    +AC  ++  A+T  GE+ +
Sbjct: 515 EVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYT 574

Query: 265 WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
           WGR   G+LG G++ED  +P  +   +G+ V  +A G+
Sbjct: 575 WGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGS 612



 Score = 76.3 bits (186), Expect = 2e-14
 Identities = 39/111 (35%), Positives = 64/111 (57%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            +V  G  H TA + D  +V+SWG GD G+LGH +  +   P+ ++AL+  + + +AC  S
Sbjct: 3051 AVHSGGRHATALTVDG-KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS 3109

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H  A+T +GE+ +WG  + G+LG G     L P+ ++   G  V  +A G+
Sbjct: 3110 HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160



 Score = 74.3 bits (181), Expect = 7e-14
 Identities = 41/114 (35%), Positives = 58/114 (50%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40   ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            +  V CG+ D  T    DE  V+SWG GDFG+LG G S     PQ ++ L G    Q+ C
Sbjct: 3153 VIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIEC 3212

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                 LA+T +G V +WG+    +LG G+      PQ ++   G  +  +A GA
Sbjct: 3213 GAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGA 3266



 Score = 73.2 bits (178), Expect = 1e-13
 Identities = 36/114 (31%), Positives = 60/114 (52%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40   ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            +  + CG+ D  T    D+  V+SWG GD+G+LG G S     P  + +L G+   ++ C
Sbjct: 4145 VVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVEC 4204

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                 +A+T +G V +WG+    +LG G+ +    P+ +Q  +G  V  IA G+
Sbjct: 4205 GSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGS 4258



 Score = 70.9 bits (172), Expect = 7e-13
 Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
            +  V  G  H+   +     +Y+WG G +GRLGH +S D   P+ V+ALQG +   +AC 
Sbjct: 4093 VVDVAAGGAHSACVTA-AGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACG 4151

Query: 217  -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
              D+  L +T    V SWG    G+LG G ++   +P  I +  G+ V  +  G++
Sbjct: 4152 SGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQ 4207



 Score = 70.5 bits (171), Expect = 9e-13
 Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 2/110 (1%)
 Frame = +1

Query: 52   ICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS-- 225
            + G + T      + ++Y+ G+G  GRLG G +  V TP  ++++Q +  K++A      
Sbjct: 3990 LIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK 4049

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
            HCLA++  GEV SWG  ++G+LG G       P+ I++  GI V  +AAG
Sbjct: 4050 HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG 4099



 Score = 69.7 bits (169), Expect = 2e-12
 Identities = 37/83 (44%), Positives = 48/83 (57%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG+  + A ++D  QVYSWG GD  RLGHG    V  P+ ++ LQG K   +A  
Sbjct: 659 VVKVRCGSQFSIALTKDG-QVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAG 717

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQ 288
            +HCLA+T   EV SWG N   Q
Sbjct: 718 STHCLALTEDSEVHSWGSNDQCQ 740



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 27/93 (29%), Positives = 46/93 (49%)
 Frame = +1

Query: 100  VYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQ 279
            +Y WG    G+LG      V  P P +AL  ++  QL   +    AVT  G++ + G   
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4013

Query: 280  NGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
             G+LG+G TE    P  +++ + + +K +A  +
Sbjct: 4014 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS 4046



 Score = 51.2 bits (121), Expect = 6e-07
 Identities = 26/72 (36%), Positives = 40/72 (55%)
 Frame = +1

Query: 22   GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKX 201
            G     + ++  G+ H    +ED  +VY+WG  D G+LG G +  +  P+ V ALQG K 
Sbjct: 4245 GLQGKKVIAIATGSLHCVCCTEDG-EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKV 4303

Query: 202  KQLACXDSHCLA 237
             ++AC  +H LA
Sbjct: 4304 NRVACGSAHTLA 4315



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 29/74 (39%), Positives = 39/74 (52%)
 Frame = +1

Query: 22   GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKX 201
            G     I  V  GA H  A + D  QVY+WG  D G+ G+G +T    P  V+ L+G K 
Sbjct: 3253 GLRGKKIVHVAVGALHCLAVT-DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKI 3311

Query: 202  KQLACXDSHCLAVT 243
             ++AC  SH +A T
Sbjct: 3312 TRVACGSSHSVAWT 3325



 Score = 47.8 bits (112), Expect = 7e-06
 Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 1/92 (1%)
 Frame = +1

Query: 97   QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
            +V+ WG  D  +LG    + +  P   + L  +   Q+A       AVT+ G+V + G  
Sbjct: 2960 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019

Query: 277  QNGQLGLGTTEDSL-LPQTIQAFEGISVKMIA 369
             NG+LGLG +  ++ +P+ I A     VK +A
Sbjct: 3020 TNGRLGLGISSGTVPIPRQITALSSYVVKKVA 3051



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 2/106 (1%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           G+T + C        S +  +VY+  +          ++D   PQ V+ L      ++A 
Sbjct: 452 GVTQIACAEKRFLILSRNG-RVYTQAY----------NSDTLAPQLVQGLASRNIVKIAA 500

Query: 217 XDS--HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG 348
                H LA+   GEV SWG    G+LG G T     P+ I AF G
Sbjct: 501 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSG 546

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>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score = 87.4 bits (215), Expect = 7e-18
 Identities = 45/114 (39%), Positives = 64/114 (56%)
 Frame = +1

Query: 37   GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            G+  V CG+  + A ++    VY+WG GDF RLGHG+   V  P+ V ALQG K   +A 
Sbjct: 4295 GVVKVECGSQFSVALTKSG-AVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIAT 4353

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
               HC+A + +GEV +WG N  GQLG GT      P+ + A +G  +  +  G+
Sbjct: 4354 GSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGS 4407



 Score = 86.3 bits (212), Expect = 2e-17
 Identities = 43/111 (38%), Positives = 65/111 (58%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            +V  G  H  A +  E +VY+WG G+ G+LGHGN      P+ V+ L G+    +AC  +
Sbjct: 4140 AVNSGGKHCLALTT-EGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSA 4198

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H  A+T +G VL+WG+ + G+LG G +ED L P+ ++A  G     IA G+
Sbjct: 4199 HSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGS 4249



 Score = 86.3 bits (212), Expect = 2e-17
 Identities = 43/114 (37%), Positives = 64/114 (56%)
 Frame = +1

Query: 37   GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            G+  + CGA  + A +    +V++WG GD+ RLGHG    V  PQP+  L+G +   +A 
Sbjct: 3232 GVVQIECGAQFSLALTR-AGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAV 3290

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
               HCLAVT AG+V +WG N +GQ G G T  +  P  +   + + V  +A G+
Sbjct: 3291 GALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGS 3344



 Score = 82.4 bits (202), Expect = 2e-16
 Identities = 42/111 (37%), Positives = 64/111 (57%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            +V  G  H  A + D  +V+SWG G+ G+LGHGN T +  P+ V+AL+  K + +AC  S
Sbjct: 3077 AVHSGGKHALALTLDG-KVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSS 3135

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H  A++  GE+ +WG  + G+LG G     L P+ + A  G  V  +A G+
Sbjct: 3136 HSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGS 3186



 Score = 80.5 bits (197), Expect = 9e-16
 Identities = 41/116 (35%), Positives = 64/116 (55%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC- 216
            +  + CG+ H+ A +   H V +WG G +GRLGHG+S D   P+ V+AL G +   +AC 
Sbjct: 4190 VADIACGSAHSAAITASGH-VLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACG 4248

Query: 217  -XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
              D+  L +T    V SWG    G+LG G ++   LP  I++  G+ V  +  G++
Sbjct: 4249 SGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQ 4304



 Score = 78.2 bits (191), Expect = 5e-15
 Identities = 44/114 (38%), Positives = 59/114 (51%), Gaps = 1/114 (0%)
 Frame = +1

Query: 40   ITSVICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
            +  V CG+ D  T    ++  V+SWG GDFG+LG G S    TP  ++ L GI   Q+ C
Sbjct: 3179 VVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIEC 3238

Query: 217  XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
                 LA+T AGEV +WG+    +LG G  +    PQ I    G  V  +A GA
Sbjct: 3239 GAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGA 3292



 Score = 71.2 bits (173), Expect = 6e-13
 Identities = 35/111 (31%), Positives = 60/111 (54%), Gaps = 1/111 (0%)
 Frame = +1

Query: 49   VICGA-DHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            + CG+ D  T    D+  V+SWG GD+G+LG G S     P  +++L G+   ++ C   
Sbjct: 4245 IACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQ 4304

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
              +A+T +G V +WG+    +LG G+ +    P+ + A +G  +  IA G+
Sbjct: 4305 FSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGS 4355



 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 36/108 (33%), Positives = 54/108 (50%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCL 234
           C   H  A  +  H  YSWG G+  RLGHG++     P  + AL+    + + C  S+  
Sbjct: 623 CEGRHFLAI-DSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSA 681

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
           A+T  G +L+WGR    +LG G ++D  LP  + A     V  +A G+
Sbjct: 682 AITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGS 729



 Score = 64.3 bits (155), Expect = 7e-11
 Identities = 40/116 (34%), Positives = 60/116 (51%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQG--IKXKQLA 213
            + SV CG  ++ A +   + + +WG G + RLGHGNS D   P  V AL    +    L 
Sbjct: 670  VQSVYCGCSYSAAITCGGN-LLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALG 728

Query: 214  CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
              D+H LA+T  G V +WG    G+LG G    SL P  +++     V+ + AG++
Sbjct: 729  SGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLP--RVQRVFAGSQ 782



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 35/111 (31%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
 Frame = +1

Query: 52   ICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXD--S 225
            + G + +      + ++++ G+G  GRLG G S     P  + +LQ +  K++A      
Sbjct: 4087 LAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGK 4146

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            HCLA+T  GEV +WG  ++G+LG G       P+ ++   G+SV  IA G+
Sbjct: 4147 HCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGS 4197



 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
 Frame = +1

Query: 52   ICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS-- 225
            I G   +      + +VY+ G G  GRLG G + +V  P  +  L+    K++A      
Sbjct: 3024 IAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK 3083

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
            H LA+T+ G+V SWG  ++G+LG G       P+ ++A     ++ +A G+
Sbjct: 3084 HALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGS 3134



 Score = 53.9 bits (128), Expect = 9e-08
 Identities = 27/93 (29%), Positives = 49/93 (52%)
 Frame = +1

Query: 100  VYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQ 279
            +Y WG    G+LG    + + TP P +AL  ++  QLA  +    AVT  G++ + G   
Sbjct: 4051 IYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGS 4110

Query: 280  NGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
             G+LG+G ++   +P  + + + + VK +A  +
Sbjct: 4111 GGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNS 4143



 Score = 49.3 bits (116), Expect = 2e-06
 Identities = 27/68 (39%), Positives = 39/68 (57%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
            I S+  G+ H  A S D  +VY+WG  D G+LG G  T +  P+ V ALQG    ++ C 
Sbjct: 4348 IISIATGSLHCVACS-DSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCG 4406

Query: 220  DSHCLAVT 243
             +H LA++
Sbjct: 4407 SAHTLALS 4414



 Score = 48.1 bits (113), Expect = 5e-06
 Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
 Frame = +1

Query: 34   PGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHG----NSTDVFTPQPVKALQGIKX 201
            P +  V  G+  + A S  E Q+Y+WG      LGH     +      P+ V +LQ  + 
Sbjct: 772  PRVQRVFAGSQFSVALSS-EGQLYTWGKATC--LGHQLVERSVQGCSVPRLVSSLQHKRI 828

Query: 202  KQLACXDSHCLAVTMAGEVLSWGRNQNGQL 291
              +A   +HCLA++ +GEV  WGRN + Q+
Sbjct: 829  VDVAVSVAHCLALSSSGEVFGWGRNDSQQI 858



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 31/114 (27%), Positives = 52/114 (45%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
            +  V  GA H  A + D  QVY+WG  D G+ G GN+     P  V  L  +   ++AC 
Sbjct: 3285 VIHVAVGALHCLAVT-DAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACG 3343

Query: 220  DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
             SH +A  +     S    + G +   +T D L   ++  +E  +++ +   A+
Sbjct: 3344 SSHSIAWGLPN--ASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAK 3395



 Score = 40.8 bits (94), Expect = 8e-04
 Identities = 25/90 (27%), Positives = 39/90 (43%)
 Frame = +1

Query: 100  VYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQ 279
            V  WG  D  +LG    + V  P   + +  ++   +A        V+  G+V + G   
Sbjct: 2988 VMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGT 3047

Query: 280  NGQLGLGTTEDSLLPQTIQAFEGISVKMIA 369
            NG+LGLG T +  LP  +       VK +A
Sbjct: 3048 NGRLGLGVTHNVPLPHQLPVLRQYVVKKVA 3077



 Score = 40.8 bits (94), Expect = 8e-04
 Identities = 21/72 (29%), Positives = 41/72 (56%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLA 237
           G  H+ A +  E  V++WG GD+G+LG+GN      P  V++L  ++  ++       +A
Sbjct: 730 GDAHSLALTS-EGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQ--RVFAGSQFSVA 786

Query: 238 VTMAGEVLSWGR 273
           ++  G++ +WG+
Sbjct: 787 LSSEGQLYTWGK 798

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 84.0 bits (206), Expect = 8e-17
 Identities = 46/114 (40%), Positives = 62/114 (54%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I  V CG D  TA   D   + ++G G  G LGHGN TD+  P  V+AL G +  Q+AC 
Sbjct: 399 IKHVACG-DLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACG 457

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
            SH LA++  GE+ +WGR   G+LGLGT E    PQ +    G   + +  G +
Sbjct: 458 ASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGID 511



 Score = 57.4 bits (137), Expect = 8e-09
 Identities = 31/86 (36%), Positives = 45/86 (52%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CGA H  A S D  ++++WG GD GRLG G       PQ V    G + +++ C 
Sbjct: 451 MVQVACGASHVLALSTDG-ELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCG 509

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL 297
               + +T  G VL+ G N+  +LGL
Sbjct: 510 IDSSMILTSPGRVLACGSNRFNKLGL 535



 Score = 55.8 bits (133), Expect = 2e-08
 Identities = 36/106 (33%), Positives = 53/106 (50%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQ 207
           D   +  V  G  H+ A +      Y++G    G+LG  +      P  V+ L+GIK   
Sbjct: 565 DQEPLLCVDLGTAHSAAITASG-DCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVM 623

Query: 208 LACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 345
           +AC D+  +AV   GEV SWG+   G+LG    ED+ LP+ +Q  E
Sbjct: 624 VACGDAFTVAVGAEGEVYSWGKGTRGRLG-RRDEDAGLPRPVQLDE 668



 Score = 49.3 bits (116), Expect = 2e-06
 Identities = 37/131 (28%), Positives = 62/131 (47%), Gaps = 16/131 (12%)
 Frame = +1

Query: 31  APGITS--VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQG---- 192
           APG  +  V+CG D +   +    +V + G   F +LG  + +    P P + ++     
Sbjct: 498 APGQEAQRVVCGIDSSMILTSPG-RVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSF 556

Query: 193 -------IKXKQLACXD---SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAF 342
                  +  + L C D   +H  A+T +G+  ++G NQ+GQLG  +   S  P  +Q  
Sbjct: 557 TPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGL 616

Query: 343 EGISVKMIAAG 375
           EGI + M+A G
Sbjct: 617 EGIKMVMVACG 627



 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 10/92 (10%)
 Frame = +1

Query: 133 LGHGNST----DVFTPQP------VKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQN 282
           LG G  T     V  PQP      ++   G+  K +AC D     +T  G ++++G   N
Sbjct: 367 LGAGGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSN 426

Query: 283 GQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
           G LG G   D   P  ++A  G  +  +A GA
Sbjct: 427 GCLGHGNLTDISQPTIVEALLGYEMVQVACGA 458

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 81.3 bits (199), Expect = 5e-16
 Identities = 46/114 (40%), Positives = 61/114 (53%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I SV CG   TT  + D   + ++G G  G LGHGN  DV  P+ V+AL G +  Q++C 
Sbjct: 400 IKSVSCGDLFTTCLT-DRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCG 458

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
            SH LAVT   EV SWGR  NG+LGL T +    PQ +        + +  G +
Sbjct: 459 ASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVD 512



 Score = 52.0 bits (123), Expect = 3e-07
 Identities = 34/102 (33%), Positives = 51/102 (50%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I  +  G  H+ A +E + Q +++G    G+LG  +      P  V  LQGI     AC 
Sbjct: 570 IVYIDIGTAHSVAVTE-KGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGIT--MAACG 626

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 345
           D+  LA+   GEV +WG+   G+LG    ED  +P+ +Q  E
Sbjct: 627 DAFTLAIGAEGEVYTWGKGARGRLG-RKEEDFGIPKPVQLDE 667



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CGA H  A + +E +V+SWG GD GRLG         PQ V      + +++ C 
Sbjct: 452 LVQVSCGASHVLAVT-NEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCG 510

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL----GTTEDS 315
               + ++   ++L+ G N+  +LGL    GT E S
Sbjct: 511 VDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPS 546



 Score = 45.4 bits (106), Expect = 3e-05
 Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 20/131 (15%)
 Frame = +1

Query: 49  VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLA----- 213
           V+CG D +   S  +HQ+ + G   F +LG    +    P     ++ +   QL      
Sbjct: 507 VLCGVDCSMIMST-QHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPL 565

Query: 214 ---------CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVK-- 360
                       +H +AVT  G+  ++G NQ+GQLG      S +P  +   +GI++   
Sbjct: 566 NTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGITMAAC 625

Query: 361 ----MIAAGAE 381
                +A GAE
Sbjct: 626 GDAFTLAIGAE 636



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 19/73 (26%), Positives = 36/73 (49%)
 Frame = +1

Query: 160 FTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA 339
           F  + ++   G+  K ++C D     +T  G ++++G   NG LG G   D   P+ ++A
Sbjct: 387 FISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEA 446

Query: 340 FEGISVKMIAAGA 378
             G  +  ++ GA
Sbjct: 447 LLGYELVQVSCGA 459

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>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score = 80.5 bits (197), Expect = 9e-16
 Identities = 45/114 (39%), Positives = 66/114 (57%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTD-VFTPQPVKALQGIKXKQLAC 216
           I  V CG  H+ A S D  Q++SWG G  G+LG   + D V  P+ ++ L      Q++C
Sbjct: 86  IIHVACGESHSLALS-DRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSC 144

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS-LLPQTIQAFEGISVKMIAAG 375
            + HCLA+   G+  +WG+N +GQLGLG    S   PQ +++ EGI +  +AAG
Sbjct: 145 GNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG 198



 Score = 70.1 bits (170), Expect = 1e-12
 Identities = 40/113 (35%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG +H+    ED  +VY+ G    G+LGH    +   P+ + AL       +AC 
Sbjct: 36  VKEVACGGNHSVFLLEDG-EVYTCGLNTKGQLGHEREGN--KPEQIGALADQHIIHVACG 92

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL-LPQTIQAFEGISVKMIAAG 375
           +SH LA++  G++ SWG   +GQLGL TTEDS+ +P+ IQ     ++  ++ G
Sbjct: 93  ESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 145



 Score = 67.8 bits (164), Expect = 6e-12
 Identities = 40/115 (34%), Positives = 58/115 (50%), Gaps = 1/115 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNS-TDVFTPQPVKALQGIKXKQLAC 216
           I  V CG  H  A + D  Q ++WG    G+LG G       +PQ V++L+GI   Q+A 
Sbjct: 139 ILQVSCGNWHCLALAADG-QFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 197

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
             +H  A++++G V  WG N  GQLGL   +D   P  ++      V  I+ G E
Sbjct: 198 GGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEE 252



 Score = 58.9 bits (141), Expect = 3e-09
 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 1/115 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  + CG +HT   ++    V+++G G  G+LGH +  D   P+ V  L G +  Q+AC 
Sbjct: 244 VVYISCGEEHTAVLTKSGG-VFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACG 302

Query: 220 DSHCLA-VTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
             H LA V  +G + ++G    GQLG G T +   P  ++ +       ++A A+
Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARAD 357



 Score = 57.8 bits (138), Expect = 6e-09
 Identities = 34/114 (29%), Positives = 54/114 (47%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V  G  H+ A S     V+ WG  + G+LG  +  D  +P  VK L+  K   ++C 
Sbjct: 192 LAQVAAGGAHSFALSLSG-AVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCG 250

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
           + H   +T +G V ++G    GQLG  +  D + P+ +    G  V  IA G +
Sbjct: 251 EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQ 304



 Score = 35.0 bits (79), Expect = 0.044
 Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
 Frame = +1

Query: 109 WGWGDFGRLGHGNSTD--VFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQN 282
           WG+   G+ G   +    V  PQ    +     K++AC  +H + +   GEV + G N  
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 283 GQLG 294
           GQLG
Sbjct: 64  GQLG 67

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 79.7 bits (195), Expect = 2e-15
 Identities = 44/114 (38%), Positives = 62/114 (54%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I  V CG D  TA   D   + ++G G  G LGHG+ TD+  P  V+AL G +  Q+AC 
Sbjct: 393 IKHVACG-DFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACG 451

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
            SH LA++   E+ +WGR  +G+LGLGT E    PQ +    G   + +  G +
Sbjct: 452 ASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGID 505



 Score = 57.4 bits (137), Expect = 8e-09
 Identities = 30/86 (34%), Positives = 46/86 (53%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CGA H  A S  E ++++WG GD GRLG G       PQ V    G + +++ C 
Sbjct: 445 MVQVACGASHVLALST-ERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCG 503

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL 297
               + +T+ G+ L+ G N+  +LGL
Sbjct: 504 IDSSMILTVPGQALACGSNRFNKLGL 529



 Score = 55.8 bits (133), Expect = 2e-08
 Identities = 34/106 (32%), Positives = 52/106 (49%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQ 207
           D   + S+  G  H+ A +      Y++G    G+LG         P  V+ L+GIK   
Sbjct: 559 DQEPLLSIDLGTAHSAAVTASG-DCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAM 617

Query: 208 LACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 345
           +AC D+  +A+    EV SWG+   G+LG    ED+ LP+ +Q  E
Sbjct: 618 VACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLDE 662



 Score = 48.1 bits (113), Expect = 5e-06
 Identities = 22/51 (43%), Positives = 31/51 (60%)
 Frame = +1

Query: 223 SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           +H  AVT +G+  ++G NQ+GQLG  T   S  P  +Q  EGI + M+A G
Sbjct: 571 AHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACG 621



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 6/77 (7%)
 Frame = +1

Query: 166 PQP------VKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQ 327
           PQP      ++   G+  K +AC D     +T  G ++++G   NG LG G+  D   P 
Sbjct: 376 PQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPT 435

Query: 328 TIQAFEGISVKMIAAGA 378
            ++A  G  +  +A GA
Sbjct: 436 IVEALLGYEMVQVACGA 452

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score = 78.2 bits (191), Expect = 5e-15
 Identities = 40/113 (35%), Positives = 65/113 (57%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNS-TDVFTPQPVKALQGIKXKQLAC 216
           I  + CG  H+ A S+   ++++WG    G+LG G       TPQ V+ L G+   Q++ 
Sbjct: 140 IIQITCGDYHSLALSKGG-ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISA 198

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
            ++H +A++M+G + SWG+N+ GQLGLG TE    P  I+  +   V+ +A G
Sbjct: 199 GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACG 251



 Score = 67.4 bits (163), Expect = 8e-12
 Identities = 38/115 (33%), Positives = 62/115 (53%), Gaps = 1/115 (0%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKX 201
           G D   +  V CG  H+   ++D   ++++G G  G+LGH ++ +   P  V  L G + 
Sbjct: 239 GLDNQKVEFVACGGSHSALLTQDG-LLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRV 297

Query: 202 KQLACXDSHCLA-VTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM 363
            Q+AC   H LA V+  G+V S+G  ++GQLG G T D L+P  ++      +K+
Sbjct: 298 TQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKL 352



 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 34/112 (30%), Positives = 57/112 (50%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  +  G  H+ A S   + +YSWG  + G+LG G++     P  ++ L   K + +AC 
Sbjct: 193 LAQISAGEAHSMALSMSGN-IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACG 251

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
            SH   +T  G + ++G  ++GQLG  +T++ L P  +    G  V  IA G
Sbjct: 252 GSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACG 303



 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 3/102 (2%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +T + CG  HT AY  D  +V+S+G G  G+LG+G + D   P PVK     + K L   
Sbjct: 297 VTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELK-LESH 355

Query: 220 DSHCLAVTMAG---EVLSWGRNQNGQLGLGTTEDSLLPQTIQ 336
            S    + +AG    +L W + +N  + L  T  +L   T++
Sbjct: 356 TSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVK 397



 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 25/65 (38%), Positives = 39/65 (60%), Gaps = 1/65 (1%)
 Frame = +1

Query: 184 LQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTT-EDSLLPQTIQAFEGISVK 360
           LQ  K  Q+ C D H LA++  GE+ +WG+N +GQLG+G     +  PQ ++   G+ + 
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194

Query: 361 MIAAG 375
            I+AG
Sbjct: 195 QISAG 199

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score = 77.0 bits (188), Expect = 1e-14
 Identities = 39/113 (34%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPV-KALQGIKXKQLAC 216
           +  V CG+ H+ A + D  ++++WG+ + G++G G++ +  TP+ V   L   +   +AC
Sbjct: 130 VIEVACGSHHSMALAADG-ELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIAC 188

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
             +  +AV  +GEV  WG N NGQLGLG   + L P  + A  G+ V  I  G
Sbjct: 189 GQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCG 241



 Score = 71.6 bits (174), Expect = 4e-13
 Identities = 37/98 (37%), Positives = 54/98 (55%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           + ++ CG   + A   D  +VY WG+   G+LG GN+ +  TP  V AL G+   Q+ C 
Sbjct: 183 VVNIACGQTSSMAVL-DSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCG 241

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +H LA+T  G + +WG N  GQLG G+  + L P  I
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQI 279



 Score = 54.3 bits (129), Expect = 7e-08
 Identities = 29/99 (29%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXK-QLAC 216
           I S+  G+      + ++  VY+WG   + +LG+G +     P  V     IK   ++AC
Sbjct: 76  IKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVAC 135

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
              H +A+   GE+ +WG N  GQ+G G+T +   P+ +
Sbjct: 136 GSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKV 174



 Score = 51.2 bits (121), Expect = 6e-07
 Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 1/97 (1%)
 Frame = +1

Query: 79  YSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS-HCLAVTMAGE 255
           Y  D  +V+ +G      LG G++     P+ ++AL G K K L+     H L  T  G 
Sbjct: 36  YVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGV 95

Query: 256 VLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 366
           V +WG N   QLG GTT   + P  +Q    + +K +
Sbjct: 96  VYAWGHNGYSQLGNGTTNQGIAP--VQVCTNLLIKQV 130



 Score = 49.3 bits (116), Expect = 2e-06
 Identities = 24/79 (30%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  ++CG  HT A + DE  +Y+WG   +G+LG G+  ++ +P  +   +    +  AC 
Sbjct: 235 VNQIVCGYAHTLALT-DEGLLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAACH 293

Query: 220 DSHCLAV-TMAGEVLSWGR 273
            +H  A  T  G V  WG+
Sbjct: 294 STHTSAAKTQGGHVYMWGQ 312

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score = 75.9 bits (185), Expect = 2e-14
 Identities = 40/113 (35%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           +  V CG+ H+   + D  +V++WG+ + G++G G++ +   P+ V   LQ      +AC
Sbjct: 154 VIEVACGSYHSLVLTSDG-EVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
               C+AV   GEV  WG N NGQLGLG + +   P  + A +GI V+ +A G
Sbjct: 213 GQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACG 265



 Score = 72.4 bits (176), Expect = 2e-13
 Identities = 38/98 (38%), Positives = 55/98 (56%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           + ++ CG     A   D  +VY WG+   G+LG GNS +  TP  V ALQGI+ +++AC 
Sbjct: 207 VVTIACGQMCCMAVV-DTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACG 265

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +H L +T  G+V +WG N  GQLG G   +   P  +
Sbjct: 266 YAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG  HT   + DE QVY+WG   +G+LG GN ++   P PV   +    +  AC 
Sbjct: 259 VQRVACGYAHTLVLT-DEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACH 317

Query: 220 DSHCLAV-TMAGEVLSWGR 273
            +H  A  T  G V  WG+
Sbjct: 318 STHTSAAKTQGGHVYMWGQ 336



 Score = 48.5 bits (114), Expect = 4e-06
 Identities = 30/96 (31%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
 Frame = +1

Query: 49  VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXD-- 222
           V   A +   Y+    +++  G    G LG G+      P+ + +L G   K++AC    
Sbjct: 50  VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNG---KKIACLSYG 106

Query: 223 --SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
              H +  T  GEV +WG N   QLG GTT   L+P
Sbjct: 107 SGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP 142

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score = 75.9 bits (185), Expect = 2e-14
 Identities = 40/113 (35%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           +  V CG+ H+   + D  +V++WG+ + G++G G++ +   P+ V   LQ      +AC
Sbjct: 154 VIEVACGSYHSLVLTSDG-EVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
               C+AV   GEV  WG N NGQLGLG + +   P  + A +GI V+ +A G
Sbjct: 213 GQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACG 265



 Score = 72.4 bits (176), Expect = 2e-13
 Identities = 38/98 (38%), Positives = 55/98 (56%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           + ++ CG     A   D  +VY WG+   G+LG GNS +  TP  V ALQGI+ +++AC 
Sbjct: 207 VVTIACGQMCCMAVV-DTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACG 265

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +H L +T  G+V +WG N  GQLG G   +   P  +
Sbjct: 266 YAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG  HT   + DE QVY+WG   +G+LG GN ++   P PV   +    +  AC 
Sbjct: 259 VQRVACGYAHTLVLT-DEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACH 317

Query: 220 DSHCLAV-TMAGEVLSWGR 273
            +H  A  T  G V  WG+
Sbjct: 318 STHTSAAKTQGGHVYMWGQ 336



 Score = 48.5 bits (114), Expect = 4e-06
 Identities = 30/96 (31%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
 Frame = +1

Query: 49  VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXD-- 222
           V   A +   Y+    +++  G    G LG G+      P+ + +L G   K++AC    
Sbjct: 50  VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNG---KKIACLSYG 106

Query: 223 --SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
              H +  T  GEV +WG N   QLG GTT   L+P
Sbjct: 107 SGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP 142

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 75.1 bits (183), Expect = 4e-14
 Identities = 40/113 (35%), Positives = 61/113 (53%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQ-LAC 216
           +  V CG+ H+ A + D  +V++WG+ + G++G G++ +  TP+ V     IK    +AC
Sbjct: 130 VVEVACGSHHSMALAADG-EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
             +  +AV   GEV  WG N NGQLGLG   + L P  + A   + V  I  G
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241



 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 36/98 (36%), Positives = 51/98 (52%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  + CG   + A   D  +VY WG+   G+LG GN+ +  TP  V AL  +   Q+ C 
Sbjct: 183 VVGIACGQTSSMAVL-DNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +H LA+T  G + +WG N  GQLG G   + L P  I
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279



 Score = 56.6 bits (135), Expect = 1e-08
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIK-XKQLAC 216
           I S+  G+      S ++  VY+WG   + +LG+G +     P  V     IK   ++AC
Sbjct: 76  IKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVAC 135

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
              H +A+   GEV +WG N  GQ+G G+T +   P+ +
Sbjct: 136 GSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKV 174



 Score = 50.8 bits (120), Expect = 8e-07
 Identities = 25/79 (31%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  ++CG  HT A + DE  +Y+WG   +G+LG GN  ++ +P  +   +    +  AC 
Sbjct: 235 VNQIVCGYAHTLALT-DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACH 293

Query: 220 DSHCLAV-TMAGEVLSWGR 273
            +H  A  T  G V  WG+
Sbjct: 294 SAHTSAAKTQGGHVYMWGQ 312



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
 Frame = +1

Query: 79  YSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS-HCLAVTMAGE 255
           Y  D  +V+ +G      LG G++     P+ ++ L G K K L+     H L  T  G 
Sbjct: 36  YVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGV 95

Query: 256 VLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 366
           V +WG N   QLG GTT   + P  +Q    + +K +
Sbjct: 96  VYAWGHNGYSQLGNGTTNQGIAP--VQVCTNLLIKQV 130

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 73.2 bits (178), Expect = 1e-13
 Identities = 39/113 (34%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           +  V CG+ H+   + D  +V++WG+ + G++G G++ +   P+ V   LQ      +AC
Sbjct: 154 VIEVACGSYHSLVLTSDG-EVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIAC 212

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
                +AV   GEV  WG N NGQLGLG++ +   P  + A +GI V+ +A G
Sbjct: 213 GQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACG 265



 Score = 71.6 bits (174), Expect = 4e-13
 Identities = 37/98 (37%), Positives = 56/98 (57%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           + S+ CG   + A   D  +VY WG+   G+LG G+S +  TP  V ALQGI+ +++AC 
Sbjct: 207 VMSIACGQMCSMAVV-DTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACG 265

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +H L +T  G++ +WG N  GQLG G   +   P  +
Sbjct: 266 YAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPV 303



 Score = 57.8 bits (138), Expect = 6e-09
 Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           I S+  G+      +  + +V++WG   + +LG+G +     P  +   L   +  ++AC
Sbjct: 100 IASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVAC 159

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
              H L +T  GEV +WG N +GQ+G G+T +  +P+ +
Sbjct: 160 GSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRV 198



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG  HT   + DE Q+Y+WG   +G+LG GN ++   P PV   +    +  AC 
Sbjct: 259 VQRVACGYAHTLVLT-DEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACH 317

Query: 220 DSHCLAV-TMAGEVLSWGR 273
            +H  A  +  G V  WG+
Sbjct: 318 SAHTSAAKSQGGHVYMWGQ 336



 Score = 47.4 bits (111), Expect = 9e-06
 Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
 Frame = +1

Query: 61  ADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS-HCLA 237
           A +   Y+    +++  G    G LG G+      P+ + +L G K   L+     H + 
Sbjct: 54  AGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVL 113

Query: 238 VTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
            T  GEV +WG N   QLG GTT   L+P
Sbjct: 114 ATTDGEVFTWGHNAYSQLGNGTTNHGLVP 142

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 73.2 bits (178), Expect = 1e-13
 Identities = 39/113 (34%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           +  V CG+ H+   + D  +V++WG+ + G++G G++ +   P+ V   LQ      +AC
Sbjct: 154 VIEVACGSYHSLVLTSDG-EVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIAC 212

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
                +AV   GEV  WG N NGQLGLG++ +   P  + A +GI V+ +A G
Sbjct: 213 GQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACG 265



 Score = 70.5 bits (171), Expect = 9e-13
 Identities = 36/98 (36%), Positives = 56/98 (57%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           + ++ CG   + A   D  +VY WG+   G+LG G+S +  TP  V ALQGI+ +++AC 
Sbjct: 207 VMNIACGQMCSMAVV-DTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACG 265

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +H L +T  G++ +WG N  GQLG G   +   P  +
Sbjct: 266 YAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPV 303



 Score = 57.8 bits (138), Expect = 6e-09
 Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           I S+  G+      +  + +V++WG   + +LG+G +     P  +   L   +  ++AC
Sbjct: 100 IASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVAC 159

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
              H L +T  GEV +WG N +GQ+G G+T +  +P+ +
Sbjct: 160 GSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRV 198



 Score = 52.0 bits (123), Expect = 3e-07
 Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG  HT   + DE Q+Y+WG   +G+LG GN ++   P PV   +    +  AC 
Sbjct: 259 VQRVACGYAHTLVLT-DEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACH 317

Query: 220 DSHCLAV-TMAGEVLSWGR 273
            +H  A  T  G V  WG+
Sbjct: 318 SAHTSAAKTQGGHVYMWGQ 336



 Score = 47.8 bits (112), Expect = 7e-06
 Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 1/93 (1%)
 Frame = +1

Query: 49  VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS- 225
           V   A +   Y+    +++  G    G LG G+      P+ + +L G K   L+     
Sbjct: 50  VFGSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGP 109

Query: 226 HCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
           H +  T  GEV +WG N   QLG GTT   L+P
Sbjct: 110 HIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVP 142

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 70.1 bits (170), Expect = 1e-12
 Identities = 35/97 (36%), Positives = 56/97 (57%)
 Frame = +1

Query: 91  EHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWG 270
           E +++SWG  D G+LGHG+   +  P+ +++L+G      AC  +H LA+T  G V ++G
Sbjct: 159 EGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFG 218

Query: 271 RNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
            N+ GQLGLG   D++       + G  +  +A GAE
Sbjct: 219 ENKMGQLGLGNKTDAVPSPAQILYNGQPITKVACGAE 255



 Score = 53.9 bits (128), Expect = 9e-08
 Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQ--GIKXKQLA 213
           +  + CG +H+    + + +V+SWG+G +GRLGH    D   P+ VK     G    Q+ 
Sbjct: 323 VRDIACGINHSLIL-DSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIY 381

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
              +   AV+  G +  WG     +      + ++ P+ +Q   G  V+ +A G
Sbjct: 382 AGATCSFAVSEMGGLFFWGATNTSR------DSTMYPKAVQDLCGWKVRSLACG 429



 Score = 47.4 bits (111), Expect = 9e-06
 Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 1/81 (1%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKAL-QGIKXKQLACXDSHC 231
           CG +HT A +E+   VY++G    G+LG GN TD   P P + L  G    ++AC     
Sbjct: 200 CGRNHTLALTENG-SVYAFGENKMGQLGLGNKTDA-VPSPAQILYNGQPITKVACGAEFS 257

Query: 232 LAVTMAGEVLSWGRNQNGQLG 294
           + +   G + S+G  + GQLG
Sbjct: 258 MIMDCKGNLYSFGCPEYGQLG 278



 Score = 44.3 bits (103), Expect = 7e-05
 Identities = 34/145 (23%), Positives = 61/145 (42%), Gaps = 27/145 (18%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQ----------- 171
           ++   IT V CGA+ +    + +  +YS+G  ++G+LGH NS   +  +           
Sbjct: 242 YNGQPITKVACGAEFSMIM-DCKGNLYSFGCPEYGQLGH-NSDGKYIARAQRIEYDCELI 299

Query: 172 --------------PVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
                          +  +  +  + +AC  +H L +     V SWG    G+LG     
Sbjct: 300 ARRIAIFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQR 359

Query: 310 DSLLPQTIQAFE--GISVKMIAAGA 378
           D ++P+ ++ F+  G     I AGA
Sbjct: 360 DEMVPRLVKLFDFPGRGAAQIYAGA 384



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 21/67 (31%), Positives = 39/67 (58%), Gaps = 2/67 (2%)
 Frame = +1

Query: 154 DVFTPQPVKALQGIKXKQLACXD--SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQ 327
           +++ P     L G++ + +A     +H L +T+ G++ SWGRN  GQLG G  +   +P+
Sbjct: 126 NLWGPHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPK 185

Query: 328 TIQAFEG 348
            I++ +G
Sbjct: 186 LIESLKG 192

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 68.6 bits (166), Expect = 4e-12
 Identities = 38/116 (32%), Positives = 62/116 (53%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNS--TDVFTPQPVKALQGIKXKQLA 213
           +  V CG+D T   + DE Q+YS+G   +G LG   S  ++V  P  V         Q++
Sbjct: 410 VQKVSCGSDFTVCIT-DEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVS 468

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
           C DSH +A+T +  V SWG  + G+LGL + +D   PQ ++   G+ +  +  G++
Sbjct: 469 CGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSD 524



 Score = 66.2 bits (160), Expect = 2e-11
 Identities = 31/86 (36%), Positives = 50/86 (58%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG  H  A +  +  VYSWG G++GRLG  +  DV++PQ V+  +G+    + C 
Sbjct: 464 VDQVSCGDSHIMALTRSK-SVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCG 522

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL 297
                 +T+ G+VL+ G N++ +LGL
Sbjct: 523 SDGSFLLTLTGKVLACGLNEHNKLGL 548



 Score = 48.5 bits (114), Expect = 4e-06
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 7/115 (6%)
 Frame = +1

Query: 52  ICGADHTTAYSEDEHQVYSW-----GWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           +C  D   A    E ++Y+W     G    G+LGHG+      P+ V+ LQG   ++++C
Sbjct: 356 VCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSC 415

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAG 375
                + +T  G++ S+G +  G LG+  +  S  L P  +  F    V  ++ G
Sbjct: 416 GSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCG 470



 Score = 33.1 bits (74), Expect = 0.17
 Identities = 24/91 (26%), Positives = 40/91 (43%), Gaps = 1/91 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           I S+  G  HT A  E   ++ ++G    G+LG G+         +   L G +  +++C
Sbjct: 581 IRSISPGRTHTAAIDE-RGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSC 639

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
            D    A T    + +WG   NG+L +   E
Sbjct: 640 GDEFTTAATADNHIFAWGNGGNGRLAMTPNE 670



 Score = 32.0 bits (71), Expect = 0.37
 Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 13/100 (13%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST------DVFTPQP-------VK 180
           I +V CG+D +   +    +V + G  +  +LG    T      + F   P        K
Sbjct: 516 IVNVCCGSDGSFLLTLTG-KVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAK 574

Query: 181 ALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLG 300
            L   K + ++   +H  A+   G +L++G N+ GQLG+G
Sbjct: 575 QLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVG 614

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 67.8 bits (164), Expect = 6e-12
 Identities = 44/121 (36%), Positives = 66/121 (54%), Gaps = 1/121 (0%)
 Frame = +1

Query: 19  FGFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIK 198
           F  D P  T + CG +HT   + + +++Y +G  ++G+LG G+ + V  P  VKAL+  K
Sbjct: 32  FRNDVP--TFLSCGDEHTAVVTGN-NKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEK 88

Query: 199 XKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAG 375
            K  AC  +H L  T  G+V + G N  GQLGLG TE+      I  F     +K ++AG
Sbjct: 89  VKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAG 148

Query: 376 A 378
           +
Sbjct: 149 S 149



 Score = 59.3 bits (142), Expect = 2e-09
 Identities = 38/120 (31%), Positives = 65/120 (54%), Gaps = 6/120 (5%)
 Frame = +1

Query: 34  PG-ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQL 210
           PG +  V CG  HT   +E    VY++G G FG+LG G  T +F     KA++ IK +++
Sbjct: 242 PGKVVQVACGGGHTVVLTEKA--VYTFGLGQFGQLGLG--TFLFETSVPKAIEHIKDQKI 297

Query: 211 ---ACXDSHCLAVTMAGEVLSWGRNQNGQLGLG--TTEDSLLPQTIQAFEGISVKMIAAG 375
              AC ++H   +T  G + ++G  ++G+LGLG   + +  +P     F    V++++ G
Sbjct: 298 SFIACGENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCG 357



 Score = 50.1 bits (118), Expect = 1e-06
 Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 1/101 (0%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGI-KXKQLACXDSHC 231
           CG +HT   +E   +VY+ G  + G+LG G++ +  T   +       K KQL+   +  
Sbjct: 94  CGRNHTLVSTEGG-KVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTS 152

Query: 232 LAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS 354
            A+T  GE+  WG N  GQ+GL    +  +PQ +   + IS
Sbjct: 153 AALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVTVGKPIS 193



 Score = 44.7 bits (104), Expect = 6e-05
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I  +  G++ + A +ED  +++ WG    G++G  N T+V  PQ V    G     ++C 
Sbjct: 142 IKQLSAGSNTSAALTEDG-ELFMWGDNSEGQIGLENVTNVCVPQQVTV--GKPISWISCG 198

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGT--TEDSLLPQTIQAFEGISVKMIAAG 375
             H   VT  G++ ++G  + G+LGL      +  +PQ +    G  V++   G
Sbjct: 199 YYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPGKVVQVACGG 252

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 67.4 bits (163), Expect = 8e-12
 Identities = 35/97 (36%), Positives = 55/97 (56%)
 Frame = +1

Query: 91  EHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWG 270
           E +++SWG  + G+LGHG++  V  P+ ++AL        AC  +H LA+T  G V ++G
Sbjct: 166 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFG 225

Query: 271 RNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
            N+ GQLGLG   D++       + G  +  +A GAE
Sbjct: 226 ENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAE 262



 Score = 58.5 bits (140), Expect = 4e-09
 Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQ--GIKXKQLA 213
           +  V CGA+HT    + + +V+SWG+G +GRLGH    D   P+ VK     G    Q+ 
Sbjct: 330 VRDVACGANHTLVL-DSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIY 388

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
              +   AV+  G +  WG     +      E ++ P+ +Q   G  ++ +A G
Sbjct: 389 AGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACG 436



 Score = 45.8 bits (107), Expect = 2e-05
 Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
 Frame = +1

Query: 154 DVFTPQPVKALQGIKXKQLACXD--SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQ 327
           +++ P     L G++ + +      +H L +T  G++ SWGRN+ GQLG G T+    P+
Sbjct: 133 NLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPR 192

Query: 328 TIQAFEGISVKMIAAG 375
            I+A    ++ + A G
Sbjct: 193 LIEALSHEAIVLAACG 208



 Score = 45.4 bits (106), Expect = 3e-05
 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKAL-QGIKXKQLAC 216
           I    CG +HT A + D   V+++G    G+LG GN TD   P P + +  G    ++AC
Sbjct: 202 IVLAACGRNHTLALT-DTGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMAC 259

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLG 294
                + +   G + S+G  + GQLG
Sbjct: 260 GAEFSMLMDCKGNLYSFGCPEYGQLG 285



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 33/144 (22%), Positives = 61/144 (42%), Gaps = 27/144 (18%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQ----------- 171
           ++   IT + CGA+ +    + +  +YS+G  ++G+LGH NS   F  +           
Sbjct: 249 YNGQPITKMACGAEFSMLM-DCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELV 306

Query: 172 --------------PVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
                          +  +  +  + +AC  +H L +     V SWG    G+LG    +
Sbjct: 307 PRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 366

Query: 310 DSLLPQTIQAFE--GISVKMIAAG 375
           D ++P+ ++ F+  G     I AG
Sbjct: 367 DEMVPRLVKLFDFPGRGATQIYAG 390

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 66.6 bits (161), Expect = 1e-11
 Identities = 34/97 (35%), Positives = 54/97 (55%)
 Frame = +1

Query: 91  EHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWG 270
           E +++SWG  + G+LGHG++  V  P+ ++ L        AC  +H LA+T  G V ++G
Sbjct: 168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFG 227

Query: 271 RNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
            N+ GQLGLG   D++       + G  +  +A GAE
Sbjct: 228 ENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAE 264



 Score = 58.9 bits (141), Expect = 3e-09
 Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQ--GIKXKQLA 213
           +  V CGA+HT    + + +V+SWG+G +GRLGH    D   P+ VK     G    Q+ 
Sbjct: 332 VRDVACGANHTLVL-DSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY 390

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
              +   AV+  G +  WG     +      E ++ P+ +Q   G  ++ +A G
Sbjct: 391 AGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACG 438



 Score = 47.4 bits (111), Expect = 9e-06
 Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKAL-QGIKXKQLAC 216
           I S  CG +HT A +E    V+++G    G+LG GN TD   P P + +  G    ++AC
Sbjct: 204 IVSAACGRNHTLALTETG-SVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMAC 261

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLG 294
                + +   G + S+G  + GQLG
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLG 287



 Score = 44.3 bits (103), Expect = 7e-05
 Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 2/77 (2%)
 Frame = +1

Query: 154 DVFTPQPVKALQGIKXKQLACXD--SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQ 327
           +++ P     L G++ + +      +H L +T  G++ SWGRN+ GQLG G T+    P+
Sbjct: 135 NLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPR 194

Query: 328 TIQAFEGISVKMIAAGA 378
            I   EG+S ++I + A
Sbjct: 195 LI---EGLSHEVIVSAA 208



 Score = 43.9 bits (102), Expect = 9e-05
 Identities = 33/144 (22%), Positives = 61/144 (42%), Gaps = 27/144 (18%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQ----------- 171
           ++   IT + CGA+ +    + +  +YS+G  ++G+LGH NS   F  +           
Sbjct: 251 YNGQPITKMACGAEFSMIM-DCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELV 308

Query: 172 --------------PVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
                          +  +  +  + +AC  +H L +     V SWG    G+LG    +
Sbjct: 309 PRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 368

Query: 310 DSLLPQTIQAFE--GISVKMIAAG 375
           D ++P+ ++ F+  G     I AG
Sbjct: 369 DEMVPRLVKLFDFPGRGASQIYAG 392

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 66.6 bits (161), Expect = 1e-11
 Identities = 38/98 (38%), Positives = 58/98 (59%), Gaps = 1/98 (1%)
 Frame = +1

Query: 91  EHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWG 270
           E +++SWG  D G+LGHG++  +  P+ ++ L        AC  +H LA+T  G V ++G
Sbjct: 141 EGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFG 200

Query: 271 RNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAGAE 381
            N+ GQLG G   D++L P TIQ + G  +  +A GAE
Sbjct: 201 ENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAE 237



 Score = 58.9 bits (141), Expect = 3e-09
 Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 2/111 (1%)
 Frame = +1

Query: 49  VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQ--GIKXKQLACXD 222
           V CGA+HT    + + +V+SWG+G +GRLGH    D   P+ VK     G    Q+ C  
Sbjct: 308 VACGANHTLVL-DSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCGY 366

Query: 223 SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
               A++  G +  WG     +      E ++ P+ +Q   G  ++ +A G
Sbjct: 367 QCSFALSEMGGLFFWGVTNTSR------ESTMYPKAVQDLCGWKIRSLACG 411



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 28/85 (32%), Positives = 41/85 (48%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I +  CG +HT A +E+   VY++G    G+LG GN TD           G    ++AC 
Sbjct: 177 IVAAACGRNHTLALTENG-TVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACG 235

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLG 294
               + V   G + S+G  + GQLG
Sbjct: 236 AEFSMIVDCKGNLYSFGCPEYGQLG 260



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 25/132 (18%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQP---------- 174
           ++   I  V CGA+ +    + +  +YS+G  ++G+LGH NS   F  +           
Sbjct: 224 YNGQPIVKVACGAEFSMIV-DCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEFDCELI 281

Query: 175 ---------------VKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
                          V  +  +  + +AC  +H L +     V SWG    G+LG    +
Sbjct: 282 PRRVAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 341

Query: 310 DSLLPQTIQAFE 345
           D ++P+ ++ F+
Sbjct: 342 DEMVPRLVKLFD 353



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 22/52 (42%), Positives = 31/52 (59%)
 Frame = +1

Query: 223 SHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA 378
           +H L +T  G++ SWGRN  GQLG G T+    P+ I   EG+  ++I A A
Sbjct: 133 AHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLI---EGLGEEVIVAAA 181

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 65.9 bits (159), Expect = 2e-11
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 1/109 (0%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCL 234
           CG +HT A     +++Y +G  ++G+LG G+   +  P  +KAL+  K K  AC  +H L
Sbjct: 42  CGDEHT-AIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTL 100

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTED-SLLPQTIQAFEGISVKMIAAGA 378
             T  G V + G N  GQLGLG T+D     Q +      ++K ++AGA
Sbjct: 101 VSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGA 149



 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 5/117 (4%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQL--- 210
           +  V CG  HT   +E    VY++G G FG+LG G  T +F     K ++ IK +++   
Sbjct: 245 VIQVACGGGHTVVLTEKV--VYAFGLGQFGQLGLG--TFLFETSEPKIIERIKDQKICHI 300

Query: 211 ACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGISVKMIAAG 375
           +C ++H   +T  G + ++G  ++G+LGLG     +   P     F   +V++IA G
Sbjct: 301 SCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACG 357



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 33/101 (32%), Positives = 49/101 (48%), Gaps = 1/101 (0%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFT-PQPVKALQGIKXKQLACXDSHC 231
           CG +HT   S D   VY+ G  + G+LG G++ D  T  Q V        KQL+   +  
Sbjct: 94  CGRNHTLV-STDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTS 152

Query: 232 LAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS 354
            A+T  G++  WG N  GQ+GL    +  +P  +   + IS
Sbjct: 153 AALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKPIS 193



 Score = 45.1 bits (105), Expect = 4e-05
 Identities = 28/89 (31%), Positives = 47/89 (52%)
 Frame = +1

Query: 31  APGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQL 210
           A  I  +  GA+ + A +ED  +++ WG    G++G  + ++V  P  V    G     +
Sbjct: 139 ADTIKQLSAGANTSAALTEDG-KLFMWGDNSEGQIGLEDKSNVCIPHEVTV--GKPISWI 195

Query: 211 ACXDSHCLAVTMAGEVLSWGRNQNGQLGL 297
           +C   H   VTM GE+ ++G  +NG+LGL
Sbjct: 196 SCGYYHSAFVTMDGELYTFGEPENGKLGL 224



 Score = 40.0 bits (92), Expect = 0.001
 Identities = 21/56 (37%), Positives = 30/56 (53%)
 Frame = +1

Query: 208 LACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           L+C D H   VT   ++  +G N  GQLGLG+    + P  I+A +   VK+ A G
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACG 95

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 64.7 bits (156), Expect = 5e-11
 Identities = 38/109 (34%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCL 234
           CG +H+   + + +++Y +G  ++G+LG G+ + +  P  VKAL+  K K  AC  +H L
Sbjct: 42  CGDEHSAVVTGN-NKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL 100

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAGA 378
             T  G V + G N  GQLGLG TE+      I  F     +K ++AG+
Sbjct: 101 VSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGS 149



 Score = 58.5 bits (140), Expect = 4e-09
 Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 5/117 (4%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLA-- 213
           +  V CG +HT   +E+   VY++G G FG+LG G  T +F     K ++ I+ + ++  
Sbjct: 245 VIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLG--TFLFETSEPKVIENIRDQTISYI 300

Query: 214 -CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGISVKMIAAG 375
            C ++H   +T  G + ++G  ++G+LGLG     +  +P     F    VK++A G
Sbjct: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357



 Score = 48.1 bits (113), Expect = 5e-06
 Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
 Frame = +1

Query: 55  CGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGI-KXKQLACXDSHC 231
           CG +HT   +E  + VY+ G  + G+LG G++ +  T   +       K KQL+   +  
Sbjct: 94  CGRNHTLVSTEGGN-VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTS 152

Query: 232 LAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS 354
            A+T  G +  WG N  GQ+GL    +  +PQ +   + +S
Sbjct: 153 AALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVS 193



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 27/86 (31%), Positives = 45/86 (52%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I  +  G++ + A +ED  +++ WG    G++G  N ++V  PQ V    G     ++C 
Sbjct: 142 IKQLSAGSNTSAALTEDG-RLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCG 198

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL 297
             H   VT  GE+  +G  +NG+LGL
Sbjct: 199 YYHSAFVTTDGELYVFGEPENGKLGL 224



 Score = 38.9 bits (89), Expect = 0.003
 Identities = 20/56 (35%), Positives = 29/56 (51%)
 Frame = +1

Query: 208 LACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           L+C D H   VT   ++  +G N  GQLGLG+      P  ++A +   VK+ A G
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 60.8 bits (146), Expect = 7e-10
 Identities = 33/91 (36%), Positives = 48/91 (52%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
            I SV CG  H+ A    E  +Y+WG G   +LGHGN  +   P  V    G K   ++  
Sbjct: 1024 IVSVACGLSHS-ALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLG 1082

Query: 220  DSHCLAVTMAGEVLSWGRNQNGQLGLGTTED 312
            ++H +A T  G V +WG+N  GQ G+ T ++
Sbjct: 1083 NNHTIASTDDGSVFAWGKNDFGQCGVLTKKN 1113



 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 32/92 (34%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
 Frame = +1

Query: 28   DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHG--NSTDVFTPQPVKALQGIKX 201
            D P I  + CG  H+ A+   +  ++++GWG +G+LGHG  N+++   P  V  L   K 
Sbjct: 825  DWPAIEKIACGQFHS-AFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKV 882

Query: 202  KQLACXDSHCLAVTMAGEVLSWGRNQNGQLGL 297
             Q+AC  +H + +T  G VL  G    GQ+G+
Sbjct: 883  TQIACGRAHTVVLTDTGRVLVCGSGSYGQMGV 914



 Score = 38.5 bits (88), Expect = 0.004
 Identities = 31/112 (27%), Positives = 49/112 (43%), Gaps = 2/112 (1%)
 Frame = +1

Query: 46   SVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDS 225
            ++ CGA+H    S    Q+ +WG   FG+ G G+S  +     V        +++AC   
Sbjct: 780  AIACGAEHILVLSSSG-QLSAWGGNRFGQCGVGHSFRIANLHQVDG-DWPAIEKIACGQF 837

Query: 226  HCLAVTMAGEVLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAG 375
            H   +   G + ++G    GQLG G   +S  L+P  +       V  IA G
Sbjct: 838  HSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIACG 888



 Score = 34.7 bits (78), Expect = 0.057
 Identities = 13/37 (35%), Positives = 24/37 (64%)
 Frame = +1

Query: 190 GIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLG 300
           G + + +AC   H L ++ +G++ +WG N+ GQ G+G
Sbjct: 775 GGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVG 811



 Score = 33.1 bits (74), Expect = 0.17
 Identities = 17/53 (32%), Positives = 26/53 (49%)
 Frame = +1

Query: 208  LACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI 366
            +AC  SH   +T  G + +WG+  + QLG G   + + P   Q FE    K +
Sbjct: 1027 VACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPH--QVFEPNGAKWV 1077

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 60.1 bits (144), Expect = 1e-09
 Identities = 34/116 (29%), Positives = 58/116 (50%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHG--NSTDVFTPQPVKALQGIKXKQLA 213
           I  V CG D T   + DE Q+Y++G   +G +G    +  +V  P  +        +Q++
Sbjct: 428 IHQVSCGDDFTVCVT-DEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVS 486

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
           C D+H + +T   EV SWG  + G+LGL + ED   PQ +   + + +  +  G +
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCD 542



 Score = 58.9 bits (141), Expect = 3e-09
 Identities = 29/86 (33%), Positives = 48/86 (55%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG +H    + ++ +VYSWG G++GRLG  +  D +TPQ V   + +    + C 
Sbjct: 482 VEQVSCGDNHVVVLTRNK-EVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCG 540

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL 297
                 +T +G+VL+ G N+  +LGL
Sbjct: 541 CDGTFLLTQSGKVLACGLNEFNKLGL 566



 Score = 48.1 bits (113), Expect = 5e-06
 Identities = 30/115 (26%), Positives = 54/115 (46%), Gaps = 7/115 (6%)
 Frame = +1

Query: 52  ICGADHTTAYSEDEHQVYSW-----GWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           +C  +   A    E ++Y+W     G    G+LGHG+      P+ V+ LQG    Q++C
Sbjct: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSC 433

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGISVKMIAAG 375
            D   + VT  G++ ++G +  G +G+      + L P  +  F    V+ ++ G
Sbjct: 434 GDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCG 488



 Score = 37.0 bits (84), Expect = 0.012
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           I ++  G  HT A  E   ++ ++G    G+LG GN         +   L G +  +++C
Sbjct: 599 IRTIAPGKTHTAAIDE-RGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
            D   +A T    + +WG   NG+L +  TE
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688



 Score = 35.0 bits (79), Expect = 0.044
 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 13/106 (12%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGN------STDVFTPQP-------VK 180
           I +V CG D T   ++   +V + G  +F +LG         + + +   P        K
Sbjct: 534 IVAVQCGCDGTFLLTQSG-KVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAK 592

Query: 181 ALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL 318
            L   K + +A   +H  A+   G +L++G N+ GQLG+G  +  L
Sbjct: 593 QLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 638

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGN--STDVFTPQPVKALQGIKXKQLA 213
           I  V CG D T   + DE Q+Y++G   +G +G       +V  P  +        +Q++
Sbjct: 428 IHQVSCGDDFTVCVT-DEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVS 486

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
           C D+H + +T   EV SWG  + G+LGL + ED   PQ +   + + +  +  G +
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCD 542



 Score = 59.3 bits (142), Expect = 2e-09
 Identities = 29/86 (33%), Positives = 48/86 (55%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           +  V CG +H    + ++ +VYSWG G++GRLG  +  D +TPQ V   + +    + C 
Sbjct: 482 VEQVSCGDNHVVVLTRNK-EVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG 540

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL 297
                 +T +G+VL+ G N+  +LGL
Sbjct: 541 CDGTFLLTQSGKVLACGLNEFNKLGL 566



 Score = 47.8 bits (112), Expect = 7e-06
 Identities = 30/115 (26%), Positives = 54/115 (46%), Gaps = 7/115 (6%)
 Frame = +1

Query: 52  ICGADHTTAYSEDEHQVYSW-----GWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           +C  +   A    E ++Y+W     G    G+LGHG+      P+ V+ LQG    Q++C
Sbjct: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSC 433

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTT--EDSLLPQTIQAFEGISVKMIAAG 375
            D   + VT  G++ ++G +  G +G+      + L P  +  F    V+ ++ G
Sbjct: 434 GDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCG 488



 Score = 37.0 bits (84), Expect = 0.012
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           I ++  G  HT A  E   ++ ++G    G+LG GN         +   L G +  +++C
Sbjct: 599 IRTIAPGKTHTAAIDE-RGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
            D   +A T    + +WG   NG+L +  TE
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688



 Score = 35.0 bits (79), Expect = 0.044
 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 13/106 (12%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGN------STDVFTPQP-------VK 180
           I +V CG D T   ++   +V + G  +F +LG         + + +   P        K
Sbjct: 534 IVAVQCGCDGTFLLTQSG-KVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAK 592

Query: 181 ALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSL 318
            L   K + +A   +H  A+   G +L++G N+ GQLG+G  +  L
Sbjct: 593 QLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 638

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 37/114 (32%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           +  V+CG DH+  +  D+ +VYS GWG  G+ G G+     TP  +   L G+   Q+A 
Sbjct: 229 VVQVVCGQDHSL-FLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVAT 287

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI-SVKMIAAG 375
               CLA++  G V  WG ++  QL   T    +       F G+  VK +A G
Sbjct: 288 YGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACG 341



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 6/101 (5%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDV--FTPQPVKALQG----IKX 201
           +  V CG       + + H V+ WG+G  G+      T +    P  +  L      ++ 
Sbjct: 335 VKQVACGGTGCAVLNAEGH-VFVWGYGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQV 393

Query: 202 KQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
            Q+ C  SH  A+T  GE+  WG+N  G LG+G  ED   P
Sbjct: 394 SQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 434



 Score = 41.2 bits (95), Expect = 6e-04
 Identities = 35/128 (27%), Positives = 53/128 (41%), Gaps = 19/128 (14%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWG--DFGRLGHGNSTDVFT------------PQPV 177
           I+S  CG   T   S+ +     WG G     +LG   S    T            P P+
Sbjct: 106 ISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPL 165

Query: 178 KALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQT-----IQAF 342
              Q  K  Q++C  +H L +T    V S G N +GQ G    ED +  ++     +Q F
Sbjct: 166 DRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDF 225

Query: 343 EGISVKMI 366
           +G  V+++
Sbjct: 226 DGQVVQVV 233



 Score = 37.7 bits (86), Expect = 0.007
 Identities = 32/115 (27%), Positives = 48/115 (41%), Gaps = 5/115 (4%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA--LQGIKXK--Q 207
           +  V CG  H+   + D   V+S G    G+ G     D    +  K   +Q    +  Q
Sbjct: 173 VLQVSCGRAHSLVLT-DREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQ 231

Query: 208 LACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIA 369
           + C   H L +T  GEV S G   +GQ GLG    +  P  +     G++V  +A
Sbjct: 232 VVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVA 286

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 58.5 bits (140), Expect = 4e-09
 Identities = 37/99 (37%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
 Frame = +1

Query: 97  QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
           +V++WG G  G+LGHG+      P  VK L G +   L    SH LA+T   +V SWG N
Sbjct: 521 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSN 580

Query: 277 QNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAE 381
             GQLG      S  P T+     +S    V  +AAG +
Sbjct: 581 TFGQLG-----HSEFPTTVPRLSKVSSENGVWSVAAGQD 614



 Score = 51.2 bits (121), Expect = 6e-07
 Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 8/121 (6%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQG-------IK 198
           + +V  G+ H+ A +E    VY WG    G+    N   V  P PV            ++
Sbjct: 93  VITVATGSFHSGAVTESG-VVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLAVR 151

Query: 199 XKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 375
             QLAC + H LA++++ E+ +WG     QLGL TT   +  PQ ++   G  V  +A G
Sbjct: 152 ILQLACGEEHTLALSLSREIWAWG--TGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACG 209

Query: 376 A 378
           A
Sbjct: 210 A 210



 Score = 33.1 bits (74), Expect = 0.17
 Identities = 16/52 (30%), Positives = 27/52 (51%)
 Frame = +1

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           ++  L  ++  EV +WG+ + GQLG G     L P  ++  +G  V  + AG
Sbjct: 510 EADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAG 561



 Score = 30.8 bits (68), Expect = 0.83
 Identities = 26/98 (26%), Positives = 39/98 (39%), Gaps = 2/98 (2%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPV--KALQGI 195
           G+    +     G  H    +ED  +VYS+G   +       S ++    P+   AL G 
Sbjct: 37  GWGGKTVLQAALGVRHGVLLTEDG-EVYSFGTLPW----KSESAEICPSSPLLESALVGH 91

Query: 196 KXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
               +A    H  AVT +G V  WG N  GQ  +   +
Sbjct: 92  HVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQ 129

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 57.8 bits (138), Expect = 6e-09
 Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
 Frame = +1

Query: 100 VYSWGWGDFGRLGHGNSTDVFTPQPVKAL-QGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
           +++WG   +G+LG G+  DVF PQ +    Q    K +     H   VT  G++   G N
Sbjct: 17  LFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLN 76

Query: 277 QNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           ++GQLGLG TE+ L     +   G  ++ +A G
Sbjct: 77  KDGQLGLGHTEEVLRFTICKPLRGCPIRQVACG 109



 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQL-- 210
           G T + CG++H  A   D+    SWGW + G  G G  ++V+TP PV+AL     + L  
Sbjct: 334 GATEISCGSEHNLAVIRDK--CCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLV 391

Query: 211 ACXDSHCLAV 240
            C   H LAV
Sbjct: 392 GCGAGHSLAV 401



 Score = 47.8 bits (112), Expect = 7e-06
 Identities = 37/135 (27%), Positives = 60/135 (44%), Gaps = 18/135 (13%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHG------------NSTDVF-- 162
           F    +T+V  G  H  A +E   +V++WG  D+G+LG              +S+  F  
Sbjct: 262 FQDEKVTAVWSGWTHLVAKTETG-KVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQG 320

Query: 163 ----TPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQT 330
                P P+  L G    +++C   H LAV +  +  SWG N++G  G GT  +   P  
Sbjct: 321 PQNSVPSPLHCLTG--ATEISCGSEHNLAV-IRDKCCSWGWNEHGMCGDGTESNVWTPTP 377

Query: 331 IQAFEGISVKMIAAG 375
           +QA      +++  G
Sbjct: 378 VQALPPSPSRLLLVG 392



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 1/113 (0%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
           I SV  G  H+   + D   ++  G    G+LG G++ +V      K L+G   +Q+AC 
Sbjct: 51  IKSVTGGGGHSAVVT-DGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACG 109

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGL-GTTEDSLLPQTIQAFEGISVKMIAAG 375
               + +T  G+VLS G N  GQLG+       ++PQ I+      V  +AAG
Sbjct: 110 WDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLRE-KVVCVAAG 161



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 4/95 (4%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA----LQ 189
           G +       + G+DH+ + + D  ++Y WG    G+L    S  VF P P +      Q
Sbjct: 208 GLENSTAVCAVAGSDHSASLT-DTGELYVWGRNKHGQLA---SRAVFLPLPQRIEAHYFQ 263

Query: 190 GIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLG 294
             K   +    +H +A T  G+V +WGR   GQLG
Sbjct: 264 DEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLG 298



 Score = 38.1 bits (87), Expect = 0.005
 Identities = 19/47 (40%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
 Frame = +1

Query: 238 VTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAF-EGISVKMIAAG 375
           V+ A  + +WG N  GQLGLG  ED  LPQ +  F +   +K +  G
Sbjct: 11  VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGG 57



 Score = 36.6 bits (83), Expect = 0.015
 Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 7/107 (6%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWG---DFGRLGHGNSTDVF-TPQPVKALQGIKXKQ 207
           +  V  G  H  A +     V+ WG G      RL  G +  +F T +    + G++   
Sbjct: 155 VVCVAAGLRHALATTATG-SVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENST 213

Query: 208 LACX---DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA 339
             C      H  ++T  GE+  WGRN++GQL         LPQ I+A
Sbjct: 214 AVCAVAGSDHSASLTDTGELYVWGRNKHGQLA-SRAVFLPLPQRIEA 259

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 38/99 (38%), Positives = 48/99 (48%), Gaps = 4/99 (4%)
 Frame = +1

Query: 97  QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
           +V++WG G  G+LGHG+      P  VK L G +   L     H LA+T   +V SWG N
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 277 QNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAE 381
             GQLG      S  P T+     IS    V  IAAG +
Sbjct: 587 TFGQLG-----HSDFPTTVPRLAKISSENGVWSIAAGRD 620



 Score = 52.0 bits (123), Expect = 3e-07
 Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 8/121 (6%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-------LQGIK 198
           + +V  G+ H+ A + D    Y WG    G+    N   V  P PV         L  ++
Sbjct: 93  VITVATGSFHSGAVT-DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR 151

Query: 199 XKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 375
             QLAC + H LA++++ E+ +WG     QLGL TT   +  PQ ++   G  V  +A G
Sbjct: 152 ILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209

Query: 376 A 378
           A
Sbjct: 210 A 210



 Score = 33.1 bits (74), Expect = 0.17
 Identities = 16/52 (30%), Positives = 27/52 (51%)
 Frame = +1

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           ++  L  ++  EV +WG+ + GQLG G     L P  ++  +G  V  + AG
Sbjct: 516 EADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAG 567



 Score = 27.3 bits (59), Expect = 9.2
 Identities = 24/98 (24%), Positives = 36/98 (36%), Gaps = 2/98 (2%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPV--KALQGI 195
           G+    +     G  H    +ED  +VYS+G   +         ++    P+   AL G 
Sbjct: 37  GWGGKTVLQAALGVKHGVLLTEDG-EVYSFGTLPW----RSGPVEICPSSPILENALVGQ 91

Query: 196 KXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
               +A    H  AVT  G    WG N  GQ  +   +
Sbjct: 92  YVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQ 129

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 55.8 bits (133), Expect = 2e-08
 Identities = 37/99 (37%), Positives = 48/99 (48%), Gaps = 4/99 (4%)
 Frame = +1

Query: 97  QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
           +V++WG G  G+LGHG+      P  VK L G +   L     H LA+T   +V SWG N
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 277 QNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAE 381
             GQLG      S  P T+     IS    V  +AAG +
Sbjct: 587 TFGQLG-----HSDFPTTVPRLAKISSENGVWSVAAGRD 620



 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 8/121 (6%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-------LQGIK 198
           + +V  G+ H+ A + D    Y WG    G+    N   V  P PV         L  ++
Sbjct: 93  VVTVATGSFHSGAVT-DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR 151

Query: 199 XKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAG 375
             QLAC + H LA++++ E+ +WG     QLGL TT   +  PQ ++   G  V  +A G
Sbjct: 152 ILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209

Query: 376 A 378
           A
Sbjct: 210 A 210



 Score = 33.1 bits (74), Expect = 0.17
 Identities = 16/52 (30%), Positives = 27/52 (51%)
 Frame = +1

Query: 220 DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAG 375
           ++  L  ++  EV +WG+ + GQLG G     L P  ++  +G  V  + AG
Sbjct: 516 EADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAG 567



 Score = 27.7 bits (60), Expect = 7.0
 Identities = 24/98 (24%), Positives = 36/98 (36%), Gaps = 2/98 (2%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPV--KALQGI 195
           G+    +     G  H    +ED  +VYS+G   +         ++    P+   AL G 
Sbjct: 37  GWGGKTVLQAALGVKHGVLLTEDG-EVYSFGTLPW----RSGPVEICPSSPILENALVGQ 91

Query: 196 KXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
               +A    H  AVT  G    WG N  GQ  +   +
Sbjct: 92  YVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQ 129

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 30/82 (36%), Positives = 44/82 (53%)
 Frame = +1

Query: 49   VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSH 228
            V CG  H+    E+   VY++G+G  G+LGHG+      P  V+AL G   +  AC  +H
Sbjct: 907  VSCGFHHSVVLMENG-DVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAC-SNH 964

Query: 229  CLAVTMAGEVLSWGRNQNGQLG 294
               + M G+V ++G    GQLG
Sbjct: 965  TAVLLMDGQVFTFGSFSKGQLG 986



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 27/97 (27%), Positives = 45/97 (46%)
 Frame = +1

Query: 79   YSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEV 258
            +  D+H+    G GD G       T  + P  V+    ++  Q++C   H + +   G+V
Sbjct: 868  HKRDKHKD---GSGDRGEKDASKIT-TYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDV 923

Query: 259  LSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA 369
             ++G  Q+GQLG G       P  +QA  G S ++ A
Sbjct: 924  YTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 35/114 (30%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKA-LQGIKXKQLAC 216
           +  V CG DH+  +  D+ +VYS GWG  G+ G G+     +P  +   L G+   Q+A 
Sbjct: 232 VVQVACGQDHSL-FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290

Query: 217 XDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI-SVKMIAAG 375
               CLAV+  G +  WG ++  QL   T    +       F G+  V+  A G
Sbjct: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344



 Score = 45.4 bits (106), Expect = 3e-05
 Identities = 30/103 (29%), Positives = 46/103 (44%), Gaps = 8/103 (7%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVK-ALQG-------I 195
           +    CG       + + H V+ WG+G  G+    N  +   P+ +   L G       I
Sbjct: 338 VRQAACGGTGCAVLNGEGH-VFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEI 394

Query: 196 KXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
           +  ++ C  SH  A+T  GE+  WG+N  G LG+G  ED   P
Sbjct: 395 QVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437



 Score = 38.9 bits (89), Expect = 0.003
 Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 7/102 (6%)
 Frame = +1

Query: 16  SFGFDAPGITSVI---CGADHTTAYSEDEHQVYSWGWGDFGRLGHGN-STDVFTPQP-VK 180
           S   D P  T V+   CG  H+   + D   V+S G   +G+ G      ++++    V 
Sbjct: 165 SLPLDRPQETRVLQVSCGRAHSLVLT-DREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223

Query: 181 ALQGIKXK--QLACXDSHCLAVTMAGEVLSWGRNQNGQLGLG 300
            +Q    +  Q+AC   H L +T  GEV S G   +GQ GLG
Sbjct: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLG 265

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 17/131 (12%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLG--------------HGNSTDVFTPQPV 177
           + S+  G  HT A  ED  +V +WG  D  +LG               GN+  + TP  +
Sbjct: 338 VKSITGGEHHTLALLEDG-RVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTII 396

Query: 178 KALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI---QAFEG 348
             L  +   Q+ C   H LAVT  G+V SWG  +N ++G G  ++ +   T+   +A + 
Sbjct: 397 PGLTNVI--QVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKE 454

Query: 349 ISVKMIAAGAE 381
           +++++  AG +
Sbjct: 455 VAIRVAGAGGQ 465



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 33/103 (32%), Positives = 52/103 (50%), Gaps = 5/103 (4%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLG-----HGNSTDVFTPQPVKALQGIKXK 204
           I SV  G+ H+ A  +++ +VY+WG     + G           +  P  V AL+G   K
Sbjct: 281 IISVGAGSYHSFAI-DNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVK 339

Query: 205 QLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTI 333
            +   + H LA+   G VL+WGR+   QLG+    D+ LP+T+
Sbjct: 340 SITGGEHHTLALLEDGRVLAWGRDDRHQLGI---PDNALPETV 379



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 37/112 (33%), Positives = 54/112 (48%), Gaps = 6/112 (5%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWG--DFGRLGHGNSTDVFTPQPVKALQGIKXKQLA 213
           +T VIC +D+ TA   D    ++WG      G LG+ +S    T +P + ++  +  QLA
Sbjct: 176 VTKVIC-SDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKR-TAEPTQ-MRLPEICQLA 232

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE----DSLLPQTIQAFEGISV 357
               H +A+T  G+V +WG  Q  QLG    E      L PQ +     ISV
Sbjct: 233 TGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISV 284



 Score = 38.1 bits (87), Expect = 0.005
 Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 16/110 (14%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLG---------HGNSTD----VFTP 168
           D  G+  +  G  H+ A S D  +VY+WG  D   LG         +G+  D      TP
Sbjct: 106 DKVGVVDLAVGGMHSAALSHDG-RVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTP 164

Query: 169 QPVK-ALQGIKXKQLACXDSHCLAVTMAGEVLSWG--RNQNGQLGLGTTE 309
             V+ AL  ++  ++ C D+   A+T  G   +WG  R  +G LG   ++
Sbjct: 165 SKVEGALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQ 214

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 1/90 (1%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFT-PQPVKALQGIKXKQLACXDSHCL 234
           G  H T   + E + YS G  ++GRLG G   +  + P  +  L  +    +AC  S   
Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSS--VACGASVGY 358

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
           AVT  G V +WG   N QLG G  ED+  P
Sbjct: 359 AVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 38/109 (34%), Positives = 53/109 (48%), Gaps = 3/109 (2%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLA 237
           G  HT   S+   QVYS+G  D G LG   S +     P K     K  Q++  DSH  A
Sbjct: 75  GGMHTVCLSKSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAA 133

Query: 238 VTMAGEVLSWG--RNQNGQLG-LGTTEDSLLPQTIQAFEGISVKMIAAG 375
           +T  G V  WG  R+ NG +G L   + S++P  +Q    + V  +A+G
Sbjct: 134 LTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASG 180



 Score = 31.2 bits (69), Expect = 0.63
 Identities = 29/122 (23%), Positives = 50/122 (40%), Gaps = 16/122 (13%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGH-----------GNSTDVFTPQP 174
           D P +  V  G DH    + D   +Y+ G G+ G+LG                 +  P+ 
Sbjct: 171 DVP-VVKVASGNDHLVMLTADG-DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKC 228

Query: 175 V----KALQG-IKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA 339
           V    +  +G ++ +   C      A++  G V  +G +   QLG   TE   +PQ + +
Sbjct: 229 VMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTS 288

Query: 340 FE 345
           F+
Sbjct: 289 FK 290



 Score = 31.2 bits (69), Expect = 0.63
 Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 5/90 (5%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGW-----GDFGRLGHGNSTDVFTPQPVKALQGIKXK 204
           +  V  G  HT A ++D  +V+ WG      G  G L     + V    PV+    +   
Sbjct: 121 VVQVSAGDSHTAALTDDG-RVFLWGSFRDNNGVIGLLEPMKKSMV----PVQVQLDVPVV 175

Query: 205 QLACXDSHCLAVTMAGEVLSWGRNQNGQLG 294
           ++A  + H + +T  G++ + G  + GQLG
Sbjct: 176 KVASGNDHLVMLTADGDLYTLGCGEQGQLG 205

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 25/68 (36%), Positives = 34/68 (50%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLAC 216
           G T V CG++H  A        YSWGW + G  G G   +V+ P+PV+AL       + C
Sbjct: 334 GATEVSCGSEHNLAIIGGV--CYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGC 391

Query: 217 XDSHCLAV 240
              H LA+
Sbjct: 392 GAGHSLAL 399



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 36/134 (26%), Positives = 61/134 (45%), Gaps = 16/134 (11%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST---------DVFTP--Q 171
           F    +T++  G  H  A +E   ++++WG  D+G+LG    T         D F P  +
Sbjct: 262 FQNEKVTAIWSGWTHLVAQTETG-KMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSR 320

Query: 172 PVKALQGIK-----XKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQ 336
           P  ++           +++C   H LA+ + G   SWG N++G  G GT  +   P+ +Q
Sbjct: 321 PPNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379

Query: 337 AFEGISVKMIAAGA 378
           A    S  ++  GA
Sbjct: 380 ALLSSSGLLVGCGA 393



 Score = 47.4 bits (111), Expect = 9e-06
 Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXK 204
           F  P     I G    +A   D   ++  G    G+LG G++ D+    P K+L G   +
Sbjct: 45  FCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQ 104

Query: 205 QLACXDSHCLAVTMAGEVLSWGRNQNGQLGL-GTTEDSLLPQTIQAFEGISVKMIAAG 375
           Q+AC     + +T  G+VLS G N  GQLG+       ++PQ I+  +   V  IAAG
Sbjct: 105 QVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKE-KVVCIAAG 161



 Score = 40.0 bits (92), Expect = 0.001
 Identities = 22/48 (45%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
 Frame = +1

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAF-EGISVKMIAAG 375
           A   A  + +WG N  GQLGLG  ED LLPQ +  F +  SV+ I  G
Sbjct: 10  AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGG 57



 Score = 38.9 bits (89), Expect = 0.003
 Identities = 34/103 (33%), Positives = 47/103 (45%), Gaps = 11/103 (10%)
 Frame = +1

Query: 100 VYSWGWGDFG---RLGHGNSTDVF----TPQPVKALQGIKXKQLACXDSHCLAVTMAGEV 258
           V+ WG G      RL  G +  +F     P  V  L+  K   +     H  ++T AGEV
Sbjct: 174 VFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEV 233

Query: 259 LSWGRNQNGQLGLGTTEDSLL--PQTIQA--FEGISVKMIAAG 375
             WG N++GQL     E + L  PQ I+A  F+   V  I +G
Sbjct: 234 YVWGSNKHGQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSG 273

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 3/111 (2%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHG-NSTDVFTPQPVKALQGIKXKQLACXDSHCL 234
           G  H T   + E + YS G  ++GRLG G N+ +   P P+  L   K   +A   S   
Sbjct: 306 GGQHHTVCVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDLP--KINSVASGASVSY 363

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQ--TIQAFEGISVKMIAAGAE 381
           AV+  G V +WG   N QLG G  ED   P+  T +  E   V  +++G +
Sbjct: 364 AVSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQ 414



 Score = 30.0 bits (66), Expect = 1.4
 Identities = 26/117 (22%), Positives = 45/117 (38%), Gaps = 15/117 (12%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGH-----------GNSTDVFTPQPV--- 177
           +  +  G DH    + D   +Y+ G G+ G+LG                 +  PQ +   
Sbjct: 180 VIKIASGNDHLVLLTVDG-DLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLK 238

Query: 178 -KALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 345
            K    +  + + C      AV+  G V  +G +   QLG   T+    PQ + +F+
Sbjct: 239 AKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFK 295



 Score = 27.7 bits (60), Expect = 7.0
 Identities = 25/93 (26%), Positives = 42/93 (45%), Gaps = 5/93 (5%)
 Frame = +1

Query: 31  APGITSVICGADHTTAYSEDEHQVYSWGW-----GDFGRLGHGNSTDVFTPQPVKALQGI 195
           A  +  V  G  HT A +ED  +V+ +G      G  G L     + V    PV+     
Sbjct: 124 AEKVVQVSAGDSHTAALTEDG-RVFVFGSFRDNNGVIGLLEPMKKSMV----PVQVQINT 178

Query: 196 KXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLG 294
              ++A  + H + +T+ G++ + G  + GQLG
Sbjct: 179 PVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLG 211

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 51.2 bits (121), Expect = 6e-07
 Identities = 29/82 (35%), Positives = 43/82 (52%)
 Frame = +1

Query: 49   VICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSH 228
            V CG  H+    E+   VY++G+G  G+LGHG+      P  V+AL G    Q+    +H
Sbjct: 907  VSCGFHHSVVLMENG-DVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVTAGSNH 964

Query: 229  CLAVTMAGEVLSWGRNQNGQLG 294
               + M G+V ++G    GQLG
Sbjct: 965  TAVLLMDGQVFTFGSFSKGQLG 986



 Score = 38.1 bits (87), Expect = 0.005
 Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
 Frame = +1

Query: 127  GRLGHGNSTDVFT--PQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLG 300
            G  G  +++ + T  P  V+    ++  Q++C   H + +   G+V ++G  Q+GQLG G
Sbjct: 878  GERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG 937

Query: 301  TTEDSLLPQTIQAFEGISVKMIA 369
                   P  +QA  G S ++ A
Sbjct: 938  DVNSRGCPTLVQALPGPSTQVTA 960

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 50.8 bits (120), Expect = 8e-07
 Identities = 37/126 (29%), Positives = 61/126 (48%), Gaps = 9/126 (7%)
 Frame = +1

Query: 25  FDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST----DVFTPQPVKALQG 192
           F    I  +  G DH   + ++E  V++WG G   +LG             P+P     G
Sbjct: 218 FSKYNIVQLAPGKDHIL-FLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPF----G 272

Query: 193 IKX-KQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLG-TTEDSLL---PQTIQAFEGISV 357
           ++  K +A  ++HC A+T   +++SWG NQ GQ G+    ED  L   P+ +   + + +
Sbjct: 273 LRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVI 332

Query: 358 KMIAAG 375
           + IAAG
Sbjct: 333 RSIAAG 338



 Score = 39.3 bits (90), Expect = 0.002
 Identities = 32/105 (30%), Positives = 42/105 (40%), Gaps = 14/105 (13%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLG--------------HGNSTDVFTPQPV 177
           I S+  G  H+   S+D   +YS G  D   +G              HG +  V  P P 
Sbjct: 332 IRSIAAGEHHSLILSQDG-DLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAV--PLPT 388

Query: 178 KALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTED 312
           K     K K +A    H +AV   G   SWG  +   +GLG  ED
Sbjct: 389 KLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFED 433



 Score = 39.3 bits (90), Expect = 0.002
 Identities = 39/151 (25%), Positives = 54/151 (35%), Gaps = 33/151 (21%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST------------------ 153
           D   I S   G  HT A  E E  V+SWG  D G LG   S                   
Sbjct: 82  DEAKIISFAVGGMHTLALDE-ESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDED 140

Query: 154 ---DVFTPQPVKA--------LQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLG 300
              +     P K          +G K  QLA  D+   A+   GEV +WG  +  +  LG
Sbjct: 141 GDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILG 200

Query: 301 TTEDSL----LPQTIQAFEGISVKMIAAGAE 381
             +D +     P  +  F   ++  +A G +
Sbjct: 201 FYQDKIKIQKTPWKVPTFSKYNIVQLAPGKD 231



 Score = 30.8 bits (68), Expect = 0.83
 Identities = 31/98 (31%), Positives = 38/98 (38%), Gaps = 5/98 (5%)
 Frame = +1

Query: 97  QVYSWGWG--DFGRLGHGNSTDVF--TPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLS 264
           +VY+WG    + G LG          TP  V         QLA    H L +   G V +
Sbjct: 185 EVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFA 244

Query: 265 WGRNQNGQLGLGTTEDSLLPQTIQAFEGI-SVKMIAAG 375
           WG  Q  QLG    E   L        G+  VK IA+G
Sbjct: 245 WGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASG 282

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 50.8 bits (120), Expect = 8e-07
 Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 3/111 (2%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFT-PQPVKALQGIKXKQLACXDSHCL 234
           G  H T   + E + YS G  ++GRLG G   +  + P  +  L  +    +AC  S   
Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSS--VACGASVGY 358

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLP--QTIQAFEGISVKMIAAGAE 381
           AV+  G V +WG   N QLG G  ED+  P   T +  E   V  +++G +
Sbjct: 359 AVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQ 409



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 35/96 (36%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLA 237
           G  HT   S+   QVYS+G  D G LG   S +     P K     K  Q++  DSH  A
Sbjct: 75  GGMHTVCLSQSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAA 133

Query: 238 VTMAGEVLSWG--RNQNGQLG-LGTTEDSLLPQTIQ 336
           +T  G V  WG  R+ NG +G L   + S++P  +Q
Sbjct: 134 LTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ 169



 Score = 30.8 bits (68), Expect = 0.83
 Identities = 29/122 (23%), Positives = 50/122 (40%), Gaps = 16/122 (13%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST-----------DVFTPQP 174
           DAP +  V  G DH    + D   +Y+ G G+ G+LG                 +  P+ 
Sbjct: 171 DAP-VVKVASGNDHLVMLTNDG-DLYTLGCGEQGQLGRVPELFANRGGRQGLGRLLVPRC 228

Query: 175 V----KALQG-IKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQA 339
           V    +  +G ++ +   C      A++  G V  +G +   QLG   T    +PQ + +
Sbjct: 229 VLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTS 288

Query: 340 FE 345
           F+
Sbjct: 289 FK 290



 Score = 30.4 bits (67), Expect = 1.1
 Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 5/90 (5%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGW-----GDFGRLGHGNSTDVFTPQPVKALQGIKXK 204
           +  V  G  HT A +ED  +V+ WG      G  G L     + V    PV+        
Sbjct: 121 VVQVSAGDSHTAALTEDG-RVFLWGSFRDNNGVIGLLEPMKKSMV----PVQVQLDAPVV 175

Query: 205 QLACXDSHCLAVTMAGEVLSWGRNQNGQLG 294
           ++A  + H + +T  G++ + G  + GQLG
Sbjct: 176 KVASGNDHLVMLTNDGDLYTLGCGEQGQLG 205

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 3/111 (2%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFT-PQPVKALQGIKXKQLACXDSHCL 234
           G  H T   + E + YS G  ++GRLG G   +  + P  +  L  +    +AC  S   
Sbjct: 301 GGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSS--VACGASVGY 358

Query: 235 AVTMAGEVLSWGRNQNGQLGLGTTEDSLLP--QTIQAFEGISVKMIAAGAE 381
           AV+  G V +WG   N QLG G  ED+  P   T +  E   V  +++G +
Sbjct: 359 AVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQ 409



 Score = 48.5 bits (114), Expect = 4e-06
 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHCLA 237
           G  HT   ++   QVYS+G  D G LG   S +     P K     K  Q++  DSH  A
Sbjct: 75  GGMHTVCLNQSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAA 133

Query: 238 VTMAGEVLSWG--RNQNGQLG-LGTTEDSLLPQTIQ 336
           +T  G V  WG  R+ NG +G L   + S++P  +Q
Sbjct: 134 LTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ 169



 Score = 31.6 bits (70), Expect = 0.49
 Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 5/90 (5%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGW-----GDFGRLGHGNSTDVFTPQPVKALQGIKXK 204
           +  V  G  HT A +ED  +V+ WG      G  G L     + V    PV+    +   
Sbjct: 121 VVQVSAGDSHTAALTEDG-RVFLWGSFRDNNGVIGLLEPMKKSMV----PVQVQLDMPVV 175

Query: 205 QLACXDSHCLAVTMAGEVLSWGRNQNGQLG 294
           ++A  + H + +T  G++ + G  + GQLG
Sbjct: 176 KVASGNDHLVMLTTDGDLYTLGCGEQGQLG 205



 Score = 28.5 bits (62), Expect = 4.1
 Identities = 26/118 (22%), Positives = 45/118 (38%), Gaps = 16/118 (13%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGH-----------GNSTDVFTPQPVKAL 186
           +  V  G DH    + D   +Y+ G G+ G+LG                 +  P+ V   
Sbjct: 174 VVKVASGNDHLVMLTTDG-DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVLLK 232

Query: 187 QGIKXKQLACXDSHC-----LAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 345
                 ++   D+ C      A++  G V  +G +   QLG   T    +PQ + +F+
Sbjct: 233 SRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFK 290

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 49.3 bits (116), Expect = 2e-06
 Identities = 29/91 (31%), Positives = 42/91 (46%)
 Frame = +1

Query: 52  ICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHC 231
           I G  H T     + +    G  ++GRLG G+  DV     +      K   + C +   
Sbjct: 298 IAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCS 357

Query: 232 LAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
            AVT+ G++ SWG   N QLG+G  +D L P
Sbjct: 358 YAVTIDGKLYSWGSGVNNQLGVGDGDDELEP 388



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 31/116 (26%), Positives = 46/116 (39%)
 Frame = +1

Query: 34  PGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLA 213
           P    +  G  H    ++    +YS+G  D G LG   S D    +P       K   ++
Sbjct: 74  PDAVDISAGGMHNLVLTKSG-DIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCIS 132

Query: 214 CXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE 381
             DSH   +   G V +WG  ++    +G T D      I   EG     IA+GA+
Sbjct: 133 AGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGAD 188



 Score = 38.9 bits (89), Expect = 0.003
 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 3/92 (3%)
 Frame = +1

Query: 28  DAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGN---STDVFTPQPVKALQGIK 198
           D PG    I   D  +A   ++ +V++WG     R  HGN   + D     P+  ++G  
Sbjct: 123 DLPGKALCISAGDSHSACLLEDGRVFAWG---SFRDSHGNMGLTIDGNKRTPIDLMEGTV 179

Query: 199 XKQLACXDSHCLAVTMAGEVLSWGRNQNGQLG 294
              +A    H + +T AG+V + G  + GQLG
Sbjct: 180 CCSIASGADHLVILTTAGKVFTVGCAEQGQLG 211

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 30/95 (31%), Positives = 47/95 (49%)
 Frame = +1

Query: 40   ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACX 219
            +  V CG  HT   +    +VY++G   +G+LG G+   V  P  V+    I   Q+A  
Sbjct: 968  VVQVACGLHHTVVLTL-AGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAIS--QVAAG 1024

Query: 220  DSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLP 324
             +H + +T  G V ++G  Q GQLG   ++  L P
Sbjct: 1025 SNHTVLLTSKGMVYTFGNYQKGQLGRLPSDYGLKP 1059



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 26/71 (36%), Positives = 38/71 (53%)
 Frame = +1

Query: 166  PQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFE 345
            PQ ++        Q+AC   H + +T+AGEV ++G NQ GQLG G  +    P  +Q   
Sbjct: 957  PQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPG 1016

Query: 346  GISVKMIAAGA 378
             IS   +AAG+
Sbjct: 1017 AIS--QVAAGS 1025

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 41.6 bits (96), Expect = 5e-04
 Identities = 37/135 (27%), Positives = 55/135 (40%), Gaps = 20/135 (14%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLG-----------------HGNSTDVFT 165
           GI  +  G  HT A +ED  QVY+WG  D   +G                 HG+ + +  
Sbjct: 311 GIKEIAAGEHHTLALTEDG-QVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFL-- 367

Query: 166 PQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQT---IQ 336
               + L  +K K +     H  AVT  G V +WG  +    GLG + D +   T     
Sbjct: 368 ----QNLFAVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNT 423

Query: 337 AFEGISVKMIAAGAE 381
           A +   + +I AG +
Sbjct: 424 ATKNEDILLIGAGGQ 438



 Score = 41.6 bits (96), Expect = 5e-04
 Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 7/78 (8%)
 Frame = +1

Query: 85  EDEHQVYSWGWGDFGRLG----HGNSTD---VFTPQPVKALQGIKXKQLACXDSHCLAVT 243
           +  H VY+WG   +G+      +G   D   +  P  +  L     K++A  + H LA+T
Sbjct: 267 DHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEIAAGEHHTLALT 326

Query: 244 MAGEVLSWGRNQNGQLGL 297
             G+V +WGR    ++G+
Sbjct: 327 EDGQVYAWGRYDMKEIGI 344



 Score = 37.7 bits (86), Expect = 0.007
 Identities = 24/65 (36%), Positives = 30/65 (46%), Gaps = 7/65 (10%)
 Frame = +1

Query: 202 KQLACXDSHCLAVTMAGEVLSWGRNQNGQLGL----GTTEDS---LLPQTIQAFEGISVK 360
           K +A  D HC A+  +  V +WG NQ GQ  L    G  ED    + P  I       +K
Sbjct: 254 KYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIK 313

Query: 361 MIAAG 375
            IAAG
Sbjct: 314 EIAAG 318



 Score = 30.0 bits (66), Expect = 1.4
 Identities = 32/114 (28%), Positives = 44/114 (38%), Gaps = 29/114 (25%)
 Frame = +1

Query: 40  ITSVICGADHTTAYSEDEHQVYSWGWGDFGRLG----------------HGNSTD----- 156
           I     G  HT A  + +++++SWG  D   LG                +GN  D     
Sbjct: 67  IVDFAVGGMHTLAL-DGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDED 125

Query: 157 ------VFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSWG--RNQNGQLG 294
                   TP  V+ L   +  QLA  D+   A+   G+V SWG  R   G LG
Sbjct: 126 GDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLG 179

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 38.1 bits (87), Expect = 0.005
 Identities = 21/65 (32%), Positives = 36/65 (55%), Gaps = 1/65 (1%)
 Frame = +1

Query: 100 VYSWGWGDFGRLGHGNSTDVFTPQ-PVKALQGIKXKQLACXDSHCLAVTMAGEVLSWGRN 276
           VY++G     +LG G+  D+ TPQ  V    G   +++AC  +H + +T  G ++  G N
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 277 QNGQL 291
           + G+L
Sbjct: 64  RRGEL 68



 Score = 31.6 bits (70), Expect = 0.49
 Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 6/39 (15%)
 Frame = +1

Query: 40  ITSVICGADH---TTAYSEDE---HQVYSWGWGDFGRLG 138
           I  V  G++H   TTA  E +   + VY WGWG+ G  G
Sbjct: 263 IVGVATGSEHGILTTANQEGKSHCYNVYCWGWGEHGNCG 301

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
           (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
           morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 35.4 bits (80), Expect = 0.034
 Identities = 17/62 (27%), Positives = 31/62 (50%)
 Frame = +1

Query: 193 IKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAA 372
           +K   ++C + H + +     V ++G N +GQLG+G T     PQ +       +  +AA
Sbjct: 767 VKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAA 826

Query: 373 GA 378
           G+
Sbjct: 827 GS 828



 Score = 35.4 bits (80), Expect = 0.034
 Identities = 21/81 (25%), Positives = 34/81 (41%)
 Frame = +1

Query: 52  ICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQGIKXKQLACXDSHC 231
           +C + H   Y  +  +++  G        H    +V + Q +  L  +    LA   SH 
Sbjct: 574 VCASGHVYGYVSENGKIFMGGL-------HTMRVNV-SSQMLNGLDNVMISSLALGKSHG 625

Query: 232 LAVTMAGEVLSWGRNQNGQLG 294
           +AVT  G + +WG N   Q G
Sbjct: 626 VAVTRNGHLFTWGLNNMNQCG 646

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>POF9_SCHPO (O74381) F-box protein pof9|
          Length = 467

 Score = 31.6 bits (70), Expect = 0.49
 Identities = 29/81 (35%), Positives = 36/81 (44%), Gaps = 4/81 (4%)
 Frame = +1

Query: 73  TAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPV--KALQGIKXKQLACXDSHCLAVTM 246
           T  S+D + VY         +GH N+  V    PV    LQ    KQLA  D H L +T 
Sbjct: 305 TCLSDDGNTVY---------MGHANTKQV-DDDPVIHDFLQNRGIKQLAHGDHHHLYLTS 354

Query: 247 AGEVLSWGRNQN--GQLGLGT 303
              + SWG      G LGLG+
Sbjct: 355 DHSIWSWGVELRYCGCLGLGS 375

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>RSP6_CHLRE (Q01657) Flagellar radial spoke protein 6|
          Length = 459

 Score = 30.8 bits (68), Expect = 0.83
 Identities = 27/93 (29%), Positives = 38/93 (40%), Gaps = 4/93 (4%)
 Frame = -2

Query: 374 PAAIIFTEIPSKA*IVCGSSESSVVPRPSW-PFWLRPQLST--SPAMVTARQWLSXQASC 204
           P A + T+ P  A      +    VP P+W P +    ++T    A V + +W     +C
Sbjct: 342 PLATLDTDAPLPA------ATGDKVPPPAWSPVFASASVTTRNQVAGVRSNRWPGAVCAC 395

Query: 203 XILIPCSALTGWGVKTSVELPW-PSLPKSPHPQ 108
                 S   GWG+K   E  W P  P  P PQ
Sbjct: 396 AGRHFTSMYVGWGIKAGGE--WSPCPPPPPVPQ 426

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>LEU2_RHOPA (Q6ND69) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)|
           (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)
          Length = 469

 Score = 29.3 bits (64), Expect = 2.4
 Identities = 16/44 (36%), Positives = 21/44 (47%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST 153
           GF  PG T+++CG  HT+ +            G FG L HG  T
Sbjct: 119 GFTLPG-TTIVCGDSHTSTH------------GAFGALAHGIGT 149

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>LEU2_NITWN (Q3SNV3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)|
           (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)
          Length = 468

 Score = 29.3 bits (64), Expect = 2.4
 Identities = 16/44 (36%), Positives = 21/44 (47%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST 153
           GF  PG T+++CG  HT+ +            G FG L HG  T
Sbjct: 118 GFTLPG-TTIVCGDSHTSTH------------GAFGALAHGIGT 148

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>LEU22_BRAJA (Q89X34) 3-isopropylmalate dehydratase large subunit 2 (EC|
           4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM
           isomerase 2) (IPMI 2)
          Length = 468

 Score = 29.3 bits (64), Expect = 2.4
 Identities = 16/44 (36%), Positives = 21/44 (47%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNST 153
           GF  PG T+++CG  HT+ +            G FG L HG  T
Sbjct: 118 GFTLPG-TTIVCGDSHTSTH------------GAFGALAHGIGT 148

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 28.9 bits (63), Expect = 3.2
 Identities = 18/49 (36%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
 Frame = +1

Query: 208 LACXDSHCLAVTMAGEVLSWGRNQN--GQLGLGTTEDSLLPQTIQAFEG 348
           +A  D H +A+T  G + SWG      G LGLG +E  +    I  +EG
Sbjct: 551 VASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEG 599

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 28.9 bits (63), Expect = 3.2
 Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 2/65 (3%)
 Frame = +1

Query: 97  QVYSWGWGDFGRLGHGNSTDVFTPQPVKALQ--GIKXKQLACXDSHCLAVTMAGEVLSWG 270
           +V S G G+   LGH   T    P+ V   +  G+K  Q      H   +T  GEV   G
Sbjct: 153 RVLSCGEGE--ALGHPGRTTTKKPRKVDIFEEEGLKPLQAVAGGVHSAVLTSEGEVYMCG 210

Query: 271 RNQNG 285
            N+ G
Sbjct: 211 INEKG 215



 Score = 28.1 bits (61), Expect = 5.4
 Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 6/91 (6%)
 Frame = +1

Query: 58  GADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQP--VKALQGIKXKQLACXDSHC 231
           G  H      D  +V++ G      LG GN T     Q      +Q I+        S  
Sbjct: 442 GVQHVVILGSDG-KVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDSKIVGVSAK 500

Query: 232 LAVTMA----GEVLSWGRNQNGQLGLGTTED 312
           LA ++A    G   +WG +  GQLGLG  ++
Sbjct: 501 LATSIAWSEDGTAYAWGFDTTGQLGLGLKDE 531

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>PPA5_RAT (P29288) Tartrate-resistant acid phosphatase type 5 precursor (EC|
           3.1.3.2) (TR-AP) (Tartrate-resistant acid ATPase)
           (TrATPase) (Acid phosphatase 5, tartrate resistant)
          Length = 327

 Score = 28.9 bits (63), Expect = 3.2
 Identities = 11/24 (45%), Positives = 16/24 (66%)
 Frame = +1

Query: 31  APGITSVICGADHTTAYSEDEHQV 102
           A G+T+ +CG DH   Y +DE+ V
Sbjct: 232 AYGVTAYLCGHDHNLQYLQDENGV 255

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>PPA5_RABIT (O97860) Tartrate-resistant acid phosphatase type 5 precursor (EC|
           3.1.3.2) (TR-AP) (Tartrate-resistant acid ATPase)
           (TrATPase) (Acid phosphatase 5, tartrate resistant)
          Length = 325

 Score = 28.5 bits (62), Expect = 4.1
 Identities = 10/22 (45%), Positives = 15/22 (68%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQV 102
           G+T+ +CG DH   Y +DE+ V
Sbjct: 232 GVTAYLCGHDHNLQYLQDENGV 253

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>PPA5_HUMAN (P13686) Tartrate-resistant acid phosphatase type 5 precursor (EC|
           3.1.3.2) (TR-AP) (Tartrate-resistant acid ATPase)
           (TrATPase) (Acid phosphatase 5, tartrate resistant)
          Length = 325

 Score = 28.5 bits (62), Expect = 4.1
 Identities = 10/22 (45%), Positives = 15/22 (68%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQV 102
           G+T+ +CG DH   Y +DE+ V
Sbjct: 232 GVTAYLCGHDHNLQYLQDENGV 253

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>PPA5_MOUSE (Q05117) Tartrate-resistant acid phosphatase type 5 precursor (EC|
           3.1.3.2) (TR-AP) (Tartrate-resistant acid ATPase)
           (TrATPase) (Acid phosphatase 5, tartrate resistant)
          Length = 327

 Score = 28.5 bits (62), Expect = 4.1
 Identities = 10/22 (45%), Positives = 15/22 (68%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQV 102
           G+T+ +CG DH   Y +DE+ V
Sbjct: 234 GVTAYLCGHDHNLQYLQDENGV 255

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>LEU2_PSEHT (Q3IJS4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)|
           (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)
          Length = 466

 Score = 28.1 bits (61), Expect = 5.4
 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
 Frame = +1

Query: 22  GFDAPGITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHG-NSTDVFTPQPVKALQGIK 198
           G   PG T+++CG  HT+ +            G FG L HG  +++V      + LQ  K
Sbjct: 116 GITLPG-TTIVCGDSHTSTH------------GAFGALAHGIGTSEVEHVLATQTLQQKK 162

Query: 199 XKQL 210
            K L
Sbjct: 163 AKSL 166

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>TMPS9_HUMAN (Q7Z410) Transmembrane protease, serine 9 (EC 3.4.21.-)|
           (Polyserase-1) (Polyserase-I) (Polyserine protease 1)
           [Contains: Serase-1; Serase-2; Serase-3]
          Length = 1059

 Score = 28.1 bits (61), Expect = 5.4
 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 12/70 (17%)
 Frame = -2

Query: 377 APAAIIFTEIPSKA*IVCGSSES--------SVVPRPSWPF----WLRPQLSTSPAMVTA 234
           AP A   T++P      CG + +        S   R  WP+    WLR +     A++ A
Sbjct: 805 APEATTHTQLPD-----CGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVA 859

Query: 233 RQWLSXQASC 204
            +WL   A C
Sbjct: 860 ERWLLSAAHC 869

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>HD_FUGRU (P51112) Huntingtin (Huntington disease protein homolog) (HD|
           protein)
          Length = 3148

 Score = 27.7 bits (60), Expect = 7.0
 Identities = 20/79 (25%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
 Frame = +1

Query: 37  GITSVICGADHTTAYSEDEHQVYSWGWGDFGRLGHGNSTDVFTPQPVKALQ---GIKXKQ 207
           G T+++C A    A S+  + ++SW      + G+  S     P   KAL+    +  K 
Sbjct: 724 GATAILCAAIIQAALSKMRYNIHSWLASVQSKTGNPLSLVDLVPLLQKALKDESSVTCKM 783

Query: 208 LACXDSHCLAVTMAGEVLS 264
                 HC+ +++ G  LS
Sbjct: 784 ACSAVRHCI-MSLCGSTLS 801

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>SYFB_METJA (Q58508) Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20)|
           (Phenylalanine--tRNA ligase beta chain) (PheRS)
          Length = 548

 Score = 27.7 bits (60), Expect = 7.0
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
 Frame = +1

Query: 145 NSTDVFTPQPV--KALQGIKXKQLACXDSHCLAVTMAGEVLSWGRNQNGQLGLGTTE 309
           NS +  TP+ +  K  +GIK   L   D   + +   G+VLS     NG+L   TTE
Sbjct: 167 NSDEEMTPREILEKHEKGIKYAHLIKDDKFPIILDSEGDVLSMPPIINGELTRVTTE 223

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>PCNT_HUMAN (O95613) Pericentrin (Pericentrin B) (Kendrin)|
          Length = 3336

 Score = 27.3 bits (59), Expect = 9.2
 Identities = 10/19 (52%), Positives = 13/19 (68%)
 Frame = -2

Query: 143  PWPSLPKSPHPQL*TWCSS 87
            PWPSLP +PH    + CS+
Sbjct: 2238 PWPSLPVTPHSGALSLCSA 2256

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>TRA1_YEAST (P38811) Transcription-associated protein 1 (p400 kDa component of|
            SAGA)
          Length = 3744

 Score = 27.3 bits (59), Expect = 9.2
 Identities = 13/41 (31%), Positives = 20/41 (48%)
 Frame = +1

Query: 145  NSTDVFTPQPVKALQGIKXKQLACXDSHCLAVTMAGEVLSW 267
            NS D+F    +  +  I     +  DSH LA+ +A  +L W
Sbjct: 1998 NSRDLFISNIIHHMNKITFMSNSNSDSHTLAIDLASLILYW 2038


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,048,860
Number of Sequences: 219361
Number of extensions: 906680
Number of successful extensions: 3382
Number of sequences better than 10.0: 62
Number of HSP's better than 10.0 without gapping: 3015
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3292
length of database: 80,573,946
effective HSP length: 102
effective length of database: 58,199,124
effective search space used: 1396778976
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result