ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags24n16 |
|---|---|
| Clone Library Name | barley_pub |
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 313 bits (802), Expect = 3e-85 Identities = 151/211 (71%), Positives = 181/211 (85%), Gaps = 3/211 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRM 173 +AEV++LG H HLVKL+GYC+ED+ RLLVYEFMPRGSLENHLFRR PL W +R+ Sbjct: 120 LAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYFQPLSWKLRL 179 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 K+ALGAAKGLAFLH R VIYRDFKTSNILLD+EYNAKLSDFGLAKDGP GDK+HVST Sbjct: 180 KVALGAAKGLAFLHSSETR-VIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIGDKSHVST 238 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPY 533 RVMGT+GYAAPEY+ TGHLT+KSDVYSFGVVLLE++SGRR++DKNRP+GE NLVEWA+PY Sbjct: 239 RVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRRAVDKNRPSGERNLVEWAKPY 298 Query: 534 LGERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 L +R+ +R++D RL+ +S++ A K A L+ Sbjct: 299 LVNKRKIFRVIDNRLQDQYSMEEACKVATLS 329
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 313 bits (801), Expect = 4e-85 Identities = 151/211 (71%), Positives = 180/211 (85%), Gaps = 3/211 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRM 173 +AEV++LG HP+LVKL+GYC+ED+ RLLVYEFMPRGSLENHLFRR PL W +R+ Sbjct: 121 LAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSWTLRL 180 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 K+ALGAAKGLAFLH AE VIYRDFKTSNILLD+EYNAKLSDFGLAKDGP GDK+HVST Sbjct: 181 KVALGAAKGLAFLHN-AETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTGDKSHVST 239 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPY 533 R+MGTYGYAAPEY+ TGHLT+KSDVYS+GVVLLE++SGRR++DKNRP GE LVEWARP Sbjct: 240 RIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRRAVDKNRPPGEQKLVEWARPL 299 Query: 534 LGERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 L +R+ +R++D RL+ +S++ A K A LA Sbjct: 300 LANKRKLFRVIDNRLQDQYSMEEACKVATLA 330
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 300 bits (768), Expect = 2e-81 Identities = 146/211 (69%), Positives = 177/211 (83%), Gaps = 3/211 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRM 173 +AE+++LG L HP+LVKL+GYC+E++ RLLVYEFM RGSLENHLFRR PL W R+ Sbjct: 120 LAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRV 179 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 ++ALGAA+GLAFLH A+ VIYRDFK SNILLD+ YNAKLSDFGLA+DGP GD +HVST Sbjct: 180 RMALGAARGLAFLHN-AQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPMGDNSHVST 238 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPY 533 RVMGT GYAAPEY+ TGHL+ KSDVYSFGVVLLE++SGRR++DKN+P GEHNLV+WARPY Sbjct: 239 RVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKNQPVGEHNLVDWARPY 298 Query: 534 LGERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 L +RR R++DPRL+G +S+ A K A LA Sbjct: 299 LTNKRRLLRVMDPRLQGQYSLTRALKIAVLA 329
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 264 bits (674), Expect = 2e-70 Identities = 132/213 (61%), Positives = 158/213 (74%), Gaps = 5/213 (2%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP-----LPWAI 167 + EV L L HP+LV L+GYC + DQRLLVYEFMP GSLE+HL P L W + Sbjct: 129 LVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHL--HDLPPDKEALDWNM 186 Query: 168 RMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHV 347 RMKIA GAAKGL FLH++A PVIYRDFK+SNILLD ++ KLSDFGLAK GP GDK+HV Sbjct: 187 RMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKSHV 246 Query: 348 STRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWAR 527 STRVMGTYGY APEY MTG LT KSDVYSFGVV LE+++GR+++D P+GE NLV WAR Sbjct: 247 STRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQNLVAWAR 306 Query: 528 PYLGERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 P +RR+F +L DPRL+G F + + +A Sbjct: 307 PLFNDRRKFIKLADPRLKGRFPTRALYQALAVA 339
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 257 bits (656), Expect = 2e-68 Identities = 123/206 (59%), Positives = 163/206 (79%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 +EV+FLG L H +LVKL+GYC ED + LLVYEFMP+GSLE+HLFRR+ P PW +R+KI + Sbjct: 139 SEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRNDPFPWDLRIKIVI 198 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 GAA+GLAFLH +R VIYRDFK SNILLD+ Y+AKLSDFGLAK GP +K+HV+TR+MG Sbjct: 199 GAARGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEKSHVTTRIMG 257 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYLGER 545 TYGYAAPEY+ TGHL KSDV++FGVVLLE+M+G + + RP G+ +LV+W RP L + Sbjct: 258 TYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTKRPRGQESLVDWLRPELSNK 317 Query: 546 RRFYRLVDPRLEGNFSIKGAQKTAQL 623 R +++D ++G ++ K A + A++ Sbjct: 318 HRVKQIMDKGIKGQYTTKVATEMARI 343
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 251 bits (642), Expect = 1e-66 Identities = 123/203 (60%), Positives = 150/203 (73%), Gaps = 3/203 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF---RRSFPLPWAIRM 173 V EV L HP+LVKL+G+C E DQRLLVYE+MP+GSLE+HL PL W RM Sbjct: 146 VVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRM 205 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 KIA GAA+GL +LH+ PVIYRD K SNILL +Y KLSDFGLAK GP GDKTHVST Sbjct: 206 KIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSGDKTHVST 265 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPY 533 RVMGTYGY AP+Y MTG LT KSD+YSFGVVLLE+++GR+++D + + NLV WARP Sbjct: 266 RVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKDQNLVGWARPL 325 Query: 534 LGERRRFYRLVDPRLEGNFSIKG 602 +RR F ++VDP L+G + ++G Sbjct: 326 FKDRRNFPKMVDPLLQGQYPVRG 348
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 182 bits (463), Expect = 5e-46 Identities = 97/209 (46%), Positives = 136/209 (65%), Gaps = 3/209 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP---LPWAIRMKI 179 E++ L +QH +LV L+GYC E DQ++LVY FM GSL + L+ + L W R+ I Sbjct: 640 ELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSI 699 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 ALGAA+GLA+LH R VI+RD K+SNILLD AK++DFG +K P+ ++VS V Sbjct: 700 ALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGDSYVSLEV 759 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYLG 539 GT GY PEY T L+ KSDV+SFGVVLLE++SGR ++ RP E +LVEWA+PY+ Sbjct: 760 RGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRIEWSLVEWAKPYI- 818 Query: 540 ERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 + +VDP ++G + + + ++A Sbjct: 819 RASKVDEIVDPGIKGGYHAEALWRVVEVA 847
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 182 bits (461), Expect = 9e-46 Identities = 97/209 (46%), Positives = 135/209 (64%), Gaps = 3/209 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP---LPWAIRMKI 179 E++ L +QH +LV L+GYC E DQ++LVY FM GSL + L+ L W R+ I Sbjct: 639 ELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSI 698 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 ALGAA+GLA+LH R VI+RD K+SNILLD AK++DFG +K P+ ++VS V Sbjct: 699 ALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQEGDSYVSLEV 758 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYLG 539 GT GY PEY T L+ KSDV+SFGVVLLE++SGR ++ RP E +LVEWA+PY+ Sbjct: 759 RGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRVEWSLVEWAKPYI- 817 Query: 540 ERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 + +VDP ++G + + + ++A Sbjct: 818 RASKVDEIVDPGIKGGYHAEALWRVVEVA 846
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 181 bits (458), Expect = 2e-45 Identities = 88/197 (44%), Positives = 135/197 (68%), Gaps = 5/197 (2%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF----PLPWAIRM 173 +E+ L ++H HLV L+GYC++ +++LLVYE+MP+G+L HLF S PL W R+ Sbjct: 633 SEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRL 692 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 +AL A+G+ +LH A + I+RD K SNILL + AK++DFGL + PEG K + T Sbjct: 693 TLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEG-KGSIET 751 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEW-ARP 530 R+ GT+GY APEY +TG +T+K DVYSFGV+L+E+++GR+S+D+++P +LV W R Sbjct: 752 RIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRKSLDESQPEESIHLVSWFKRM 811 Query: 531 YLGERRRFYRLVDPRLE 581 Y+ + F + +D ++ Sbjct: 812 YINKEASFKKAIDTTID 828
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 174 bits (440), Expect = 3e-43 Identities = 96/210 (45%), Positives = 134/210 (63%), Gaps = 4/210 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLP----WAIRMK 176 E+D L L H HL+ L+GYC + +RLLVYEFM GSL HL + L WA R+ Sbjct: 551 ELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVT 610 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IA+ AA+G+ +LH A PVI+RD K+SNIL+D ++NA+++DFGL+ GP T +S Sbjct: 611 IAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSGTPLSEL 670 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYL 536 GT GY PEY +LT+KSDVYSFGVVLLE++SGR+++D G N+VEWA P + Sbjct: 671 PAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQFEEG--NIVEWAVPLI 728 Query: 537 GERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 + + ++DP L ++ +K A +A Sbjct: 729 -KAGDIFAILDPVLSPPSDLEALKKIASVA 757
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 164 bits (414), Expect = 3e-40 Identities = 89/198 (44%), Positives = 130/198 (65%), Gaps = 6/198 (3%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP-----LPWAI 167 +AE++ +G ++H +LV L+GYC ++RLLVYE+M GSLE L +S L WA Sbjct: 901 MAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAA 960 Query: 168 RMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHV 347 R KIA+GAA+GLAFLH +I+RD K+SN+LLD ++ A++SDFG+A+ D TH+ Sbjct: 961 RKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALD-THL 1019 Query: 348 STRVM-GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWA 524 S + GT GY PEY + T+K DVYS+GV+LLE++SG++ +D ++NLV WA Sbjct: 1020 SVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDNNLVGWA 1079 Query: 525 RPYLGERRRFYRLVDPRL 578 + E+R ++DP L Sbjct: 1080 KQLYREKRG-AEILDPEL 1096
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 160 bits (406), Expect = 2e-39 Identities = 87/197 (44%), Positives = 130/197 (65%), Gaps = 5/197 (2%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP----LPWAIR 170 +AE++ +G ++H +LV L+GYC ++RLLVYE+M GSLE L ++ L W+ R Sbjct: 900 MAEMETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSAR 959 Query: 171 MKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVS 350 KIA+GAA+GLAFLH +I+RD K+SN+LLD ++ A++SDFG+A+ D TH+S Sbjct: 960 KKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALD-THLS 1018 Query: 351 TRVM-GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWAR 527 + GT GY PEY + T+K DVYS+GV+LLE++SG++ +D ++NLV WA+ Sbjct: 1019 VSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPEEFGEDNNLVGWAK 1078 Query: 528 PYLGERRRFYRLVDPRL 578 E+R ++DP L Sbjct: 1079 QLYREKRG-AEILDPEL 1094
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 160 bits (404), Expect = 4e-39 Identities = 86/184 (46%), Positives = 117/184 (63%), Gaps = 3/184 (1%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLP---WAIRMK 176 AEV+ L QHP+LV L+GYC + +LL+Y +M GSL+ L + P W R++ Sbjct: 786 AEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLR 845 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IA GAA+GLA+LH+ E +++RD K+SNILL + A L+DFGLA+ D THV+T Sbjct: 846 IARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPYD-THVTTD 904 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYL 536 ++GT GY PEY T K DVYSFGVVLLE+++GRR MD +P G +L+ W Sbjct: 905 LVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTGRRPMDVCKPRGSRDLISWVLQMK 964 Query: 537 GERR 548 E+R Sbjct: 965 TEKR 968
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 157 bits (398), Expect = 2e-38 Identities = 83/175 (47%), Positives = 114/175 (65%), Gaps = 3/175 (1%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP---LPWAIRMK 176 AEV+ L QHP+LV L G+C + RLL+Y +M GSL+ L R+ L W R++ Sbjct: 777 AEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLR 836 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IA GAAKGL +LHE + +++RD K+SNILLD +N+ L+DFGLA+ + THVST Sbjct: 837 IAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPYE-THVSTD 895 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEW 521 ++GT GY PEY T K DVYSFGVVLLE+++ +R +D +P G +L+ W Sbjct: 896 LVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKRPVDMCKPKGCRDLISW 950
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 157 bits (397), Expect = 2e-38 Identities = 87/211 (41%), Positives = 135/211 (63%), Gaps = 5/211 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRMKI 179 EV+ + H +L++L G+C+ +RLLVY +M GS+ + L R PL W R +I Sbjct: 334 EVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRI 393 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 ALG+A+GLA+LH+ + +I+RD K +NILLD E+ A + DFGLAK D THV+T V Sbjct: 394 ALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKD-THVTTAV 452 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHN--LVEWARPY 533 GT G+ APEY+ TG + K+DV+ +GV+LLE+++G+R+ D R + + L++W + Sbjct: 453 RGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGL 512 Query: 534 LGERRRFYRLVDPRLEGNFSIKGAQKTAQLA 626 L E ++ LVD L+GN+ + ++ Q+A Sbjct: 513 LKE-KKLEALVDVDLQGNYKDEEVEQLIQVA 542
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 157 bits (396), Expect = 3e-38 Identities = 90/211 (42%), Positives = 135/211 (63%), Gaps = 4/211 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLP---WAIRM 173 +AE++ LG ++HP+LV L+GYC +++LLVYE+M GSL++ L ++ L W+ R+ Sbjct: 959 MAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRL 1018 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 KIA+GAA+GLAFLH +I+RD K SNILLD ++ K++DFGLA+ ++HVST Sbjct: 1019 KIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLAR-LISACESHVST 1077 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGE-HNLVEWARP 530 + GT+GY PEY + T+K DVYSFGV+LLE+++G+ + E NLV WA Sbjct: 1078 VIAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEPTGPDFKESEGGNLVGWAIQ 1137 Query: 531 YLGERRRFYRLVDPRLEGNFSIKGAQKTAQL 623 + + + ++DP L + A K +QL Sbjct: 1138 KINQGKA-VDVIDPLL-----VSVALKNSQL 1162
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 156 bits (394), Expect = 6e-38 Identities = 87/196 (44%), Positives = 127/196 (64%), Gaps = 4/196 (2%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF---RRSFPLPWAIRM 173 +AE++ +G ++H +LV L+GYC D+RLLVYEFM GSLE+ L + L W+ R Sbjct: 925 MAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRR 984 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 KIA+G+A+GLAFLH +I+RD K+SN+LLD A++SDFG+A+ D TH+S Sbjct: 985 KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMD-THLSV 1043 Query: 354 RVM-GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARP 530 + GT GY PEY + ++K DVYS+GVVLLE+++G+R D + G++NLV W + Sbjct: 1044 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTD-SPDFGDNNLVGWVKQ 1102 Query: 531 YLGERRRFYRLVDPRL 578 + + R + DP L Sbjct: 1103 H--AKLRISDVFDPEL 1116
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 153 bits (387), Expect = 4e-37 Identities = 85/200 (42%), Positives = 129/200 (64%), Gaps = 5/200 (2%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF---RRSFPLPWAIRMK 176 AEV+ LG ++H +V+L C D +LLVYE+MP GSL + L + L W R++ Sbjct: 736 AEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLR 795 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGP-EGDKT-HVS 350 IAL AA+GL++LH + P+++RD K+SNILLD++Y AK++DFG+AK G G KT Sbjct: 796 IALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAM 855 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARP 530 + + G+ GY APEYV T + KSD+YSFGVVLLE+++G++ D G+ ++ +W Sbjct: 856 SGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQPTDSEL--GDKDMAKWVCT 913 Query: 531 YLGERRRFYRLVDPRLEGNF 590 L ++ ++DP+L+ F Sbjct: 914 AL-DKCGLEPVIDPKLDLKF 932
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 150 bits (379), Expect = 3e-36 Identities = 82/178 (46%), Positives = 118/178 (66%), Gaps = 4/178 (2%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS---FPLPWAIRMK 176 AE++ +G ++H +LV L+GYC ++RLLVYE+M GSLE+ L R L W R K Sbjct: 931 AEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRK 990 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IA+GAA+GLAFLH +I+RD K+SN+LLD A++SDFG+A+ D TH+S Sbjct: 991 IAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMD-THLSVS 1049 Query: 357 VM-GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWAR 527 + GT GY PEY + ++K DVYS+GVVLLE+++G++ D + G++NLV W + Sbjct: 1050 TLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTD-SADFGDNNLVGWVK 1106
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 150 bits (379), Expect = 3e-36 Identities = 82/178 (46%), Positives = 118/178 (66%), Gaps = 4/178 (2%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS---FPLPWAIRMK 176 AE++ +G ++H +LV L+GYC ++RLLVYE+M GSLE+ L R L W R K Sbjct: 931 AEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRK 990 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IA+GAA+GLAFLH +I+RD K+SN+LLD A++SDFG+A+ D TH+S Sbjct: 991 IAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMD-THLSVS 1049 Query: 357 VM-GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWAR 527 + GT GY PEY + ++K DVYS+GVVLLE+++G++ D + G++NLV W + Sbjct: 1050 TLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQPTD-SADFGDNNLVGWVK 1106
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 150 bits (378), Expect = 4e-36 Identities = 84/204 (41%), Positives = 123/204 (60%), Gaps = 11/204 (5%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF-RRSFPLPWAIRMKIA 182 AE+ LG ++H H+V+L+GY D LL+YE+MP GSL L + L W R ++A Sbjct: 736 AEIQTLGRIRHRHIVRLLGYVANKDTNLLLYEYMPNGSLGELLHGSKGGHLQWETRHRVA 795 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + AAKGL +LH + +++RD K++NILLD+++ A ++DFGLAK +G + + + Sbjct: 796 VEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLVDGAASECMSSIA 855 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEH----NLVEWARP 530 G+YGY APEY T + KSDVYSFGVVLLE+++G+ +P GE ++V W R Sbjct: 856 GSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGK------KPVGEFGEGVDIVRWVRN 909 Query: 531 YLGERRR------FYRLVDPRLEG 584 E + +VDPRL G Sbjct: 910 TEEEITQPSDAAIVVAIVDPRLTG 933
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 149 bits (376), Expect = 7e-36 Identities = 86/181 (47%), Positives = 116/181 (64%), Gaps = 6/181 (3%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF-----RRSFPLPWAI 167 +AE++ LG ++H +LV L+GYC ++RLLVYEFM GSLE L + L W Sbjct: 880 MAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEE 939 Query: 168 RMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHV 347 R KIA GAAKGL FLH +I+RD K+SN+LLD + A++SDFG+A+ D TH+ Sbjct: 940 RKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALD-THL 998 Query: 348 STRVM-GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWA 524 S + GT GY PEY + T+K DVYS GVV+LE++SG+R DK G+ NLV W+ Sbjct: 999 SVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDKEE-FGDTNLVGWS 1057 Query: 525 R 527 + Sbjct: 1058 K 1058
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 145 bits (367), Expect = 7e-35 Identities = 84/201 (41%), Positives = 131/201 (65%), Gaps = 6/201 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF---RRSFPLPWAIRMKI 179 EV + LQH +LV+++G CIE D+++L+YE++ SL+++LF RRS L W R I Sbjct: 572 EVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRS-KLNWNERFDI 630 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST-R 356 G A+GL +LH+++ +I+RD K SNILLD K+SDFG+A+ E D+T +T + Sbjct: 631 TNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIF-ERDETEANTMK 689 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVE--WARP 530 V+GTYGY +PEY M G + KSDV+SFGV++LE++SG+++ + E++L+ W+R Sbjct: 690 VVGTYGYMSPEYAMYGIFSEKSDVFSFGVIVLEIVSGKKNRGFYNLDYENDLLSYVWSR- 748 Query: 531 YLGERRRFYRLVDPRLEGNFS 593 + R +VDP + + S Sbjct: 749 --WKEGRALEIVDPVIVDSLS 767
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 145 bits (366), Expect = 1e-34 Identities = 84/212 (39%), Positives = 129/212 (60%), Gaps = 3/212 (1%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF-RRSFPLPWAIRMKIA 182 AEVD L + H +L LVGYC E + +L+YE+M +L ++L +RSF L W R+KI+ Sbjct: 616 AEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFILSWEERLKIS 675 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 L AA+GL +LH + P+++RD K +NILL+ + AK++DFGL++ +ST V Sbjct: 676 LDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQISTVVA 735 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYL-- 536 G+ GY PEY T + KSDVYS GVVLLE+++G+ ++ ++ H + + R L Sbjct: 736 GSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQPAIASSKTEKVH-ISDHVRSILAN 794 Query: 537 GERRRFYRLVDPRLEGNFSIKGAQKTAQLAHA 632 G+ R +VD RL + + A K +++A A Sbjct: 795 GDIR---GIVDQRLRERYDVGSAWKMSEIALA 823
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 138 bits (348), Expect = 1e-32 Identities = 82/196 (41%), Positives = 114/196 (58%), Gaps = 3/196 (1%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRR--SFPLPWAIRMKI 179 AE+ +G + H +LV++ G+C E RLLV E++ GSL N LF + L W R I Sbjct: 576 AELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNI 635 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 ALG AKGLA+LH E VI+ D K NILLD + K++DFGL K G T + V Sbjct: 636 ALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGSTQNVSHV 695 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGE-HNLVEWARPYL 536 GT GY APE+V + +T+K DVYS+GVVLLE+++G R + E H+++ Sbjct: 696 RGTLGYIAPEWVSSLPITAKVDVYSYGVVLLELLTGTRVSELVGGTDEVHSML------- 748 Query: 537 GERRRFYRLVDPRLEG 584 R+ R++ +LEG Sbjct: 749 ---RKLVRMLSAKLEG 761
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 138 bits (348), Expect = 1e-32 Identities = 73/163 (44%), Positives = 107/163 (65%), Gaps = 2/163 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL--FRRSFPLPWAIRMKIA 182 E+ + QH +LV+L+G+ + D LVY +MP GSL + L + PL W R K+A Sbjct: 233 EIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVA 292 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ FLHE I+RD K++NILLD ++ AK+SDFGLA+ +T +++R++ Sbjct: 293 QGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASARLAQTVMTSRIV 349 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNR 491 GT Y APE + G +T KSD+YSFGVVLLE+++G ++D+NR Sbjct: 350 GTTAYMAPE-ALRGEITPKSDIYSFGVVLLELITGLAAVDENR 391
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 137 bits (346), Expect = 2e-32 Identities = 73/194 (37%), Positives = 118/194 (60%), Gaps = 2/194 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLP--WAIRMK 176 V E++ +G ++H +L+KL + + + L++Y +M GSL + L + P P W+ R Sbjct: 859 VREIETIGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPLDWSTRHN 918 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IA+G A GLA+LH + + +++RD K NILLD++ +SDFG+AK + + S Sbjct: 919 IAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSATSIPSNT 978 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYL 536 V GT GY APE T + +SDVYS+GVVLLE+++ ++++D + NGE ++V W R Sbjct: 979 VQGTIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKKALDPSF-NGETDIVGWVRSVW 1037 Query: 537 GERRRFYRLVDPRL 578 + ++VDP L Sbjct: 1038 TQTGEIQKIVDPSL 1051
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 137 bits (344), Expect = 3e-32 Identities = 74/163 (45%), Positives = 109/163 (66%), Gaps = 2/163 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL--FRRSFPLPWAIRMKIA 182 E+ + QH +LV+L+G+ + D LVY +MP GSL + L + PL W +R KIA Sbjct: 233 EIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIA 292 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 GAA G+ FLHE I+RD K++NILLD + AK+SDFGLA+ + +T +++R++ Sbjct: 293 QGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIV 349 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNR 491 GT Y APE + G +T KSD+YSFGVVLLE+++G ++D++R Sbjct: 350 GTTAYMAPE-ALRGEITPKSDIYSFGVVLLEIITGLPAVDEHR 391
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 120 bits (301), Expect = 3e-27 Identities = 67/169 (39%), Positives = 99/169 (58%), Gaps = 10/169 (5%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS---FPLPWAIRM 173 + EV+ L +HP++V GYC E LVY F+P GSLE+ L ++ PL W R+ Sbjct: 257 LTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRL 316 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK----DGPEGDKT 341 I LG A+ + FLH+++ +I+ D K+SN+LLD KL DFGLA+ G + ++ Sbjct: 317 DILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQS 375 Query: 342 HVSTR---VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSM 479 R V GT Y EY+ TG L +D +SFGVV+LE ++G+R++ Sbjct: 376 STVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAV 424
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 118 bits (295), Expect = 2e-26 Identities = 66/169 (39%), Positives = 100/169 (59%), Gaps = 10/169 (5%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRM 173 + EV+ L +HP++V GYC ++ LVY F+P GSLE+ L ++ PL W R+ Sbjct: 257 LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL 316 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK----DGPEGDKT 341 I LG A+ + FLH+++ +I+ D K+SN+LLD KL DFGLA+ G ++ Sbjct: 317 DILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQS 375 Query: 342 HVSTR---VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSM 479 + R V GT Y EY+ TG L +D +SFGVV+LE ++G+R++ Sbjct: 376 SMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAV 424
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 117 bits (294), Expect = 2e-26 Identities = 70/187 (37%), Positives = 107/187 (57%), Gaps = 7/187 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL--FRRSFPLP---WAIRM 173 E+ +L +++H +++ L GY I+ + LVY+ M GSLE L + PLP W R Sbjct: 262 ELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRF 321 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEG-DKTHVS 350 I+LG A+G+ FLH P+I+ D K +NILLD K+ DFGL ++GP+ D Sbjct: 322 SISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEV 381 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPN-GEHNLVEWAR 527 +V GT Y PE+ L++ DVYSFG+VLLE+ +GR+ D+ N + NL+++ + Sbjct: 382 NKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVK 441 Query: 528 PYLGERR 548 + R Sbjct: 442 QQWRQNR 448
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 101 bits (251), Expect = 2e-21 Identities = 56/155 (36%), Positives = 93/155 (60%), Gaps = 3/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP-LPWAIRMKIAL 185 EV + +L+HP++V + + +V EFM GSL + L P +P+A+++K+A Sbjct: 831 EVKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAY 890 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A+KG+ FLH +++RD K+ N+LLD+++N K+SDFGL K E DK + ++G Sbjct: 891 QASKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIG 947 Query: 366 TYGYAAPEYVMTGHLTS--KSDVYSFGVVLLEMMS 464 T + APE + +DVYSFG++L E+++ Sbjct: 948 TIHWIAPEILNDSTEVDYILADVYSFGIILWELLT 982 Score = 99.0 bits (245), Expect = 1e-20 Identities = 58/178 (32%), Positives = 102/178 (57%), Gaps = 1/178 (0%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 AE+ FL L+H ++V +G CI+ +V E+M G+L + L + +A ++K+ Sbjct: 1408 AEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPDIKITFANKLKLLY 1467 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 GAA G+ +LH + +++RD K +NIL+D +N K++DFG A+ + D T ++ G Sbjct: 1468 GAAMGIDYLH-SSNPMIVHRDIKPANILVDEHFNVKIADFGFAR--IKEDNTTMTR--CG 1522 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSM-DKNRPNGEHNLVEWARPYL 536 T + APE + K+DV+SFGVV+ E+++G+ + N +++E RP + Sbjct: 1523 TPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKEPFAECNFMKVSLDILEGGRPII 1580
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 98.2 bits (243), Expect = 2e-20 Identities = 53/161 (32%), Positives = 91/161 (56%), Gaps = 6/161 (3%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL--FRRSFPLPWAIRMK 176 ++E++ L +HPH+++L Y E ++ LVY +M G+L + L + PL W +R+ Sbjct: 223 LSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRIS 282 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 + +G AK + +LH VI + ++NILLD + KL+DF A P ++ + Sbjct: 283 VLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTIN 342 Query: 357 VMG----TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + G Y EY+ G L+ K+DVYSFG+V++E+++G Sbjct: 343 MTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTG 383
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 97.8 bits (242), Expect = 2e-20 Identities = 59/165 (35%), Positives = 95/165 (57%), Gaps = 4/165 (2%) Frame = +3 Query: 21 LGNLQHPHLVKLVG-YCIEDDQRLLVYEFMPRGSLENHLFR---RSFPLPWAIRMKIALG 188 LG ++H +LV L Y + ++LL+Y+++P SL + L R L WA R KIALG Sbjct: 421 LGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALG 480 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A+GLA+LH E P+I+ + ++ N+L+D + A+L++FGL K + + ++ Sbjct: 481 IARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAKSD 540 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGE 503 GY APE +SDVY+FG++LLE++ G++ R E Sbjct: 541 -GYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKPGKSGRNGNE 584
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 93.6 bits (231), Expect = 4e-19 Identities = 55/165 (33%), Positives = 91/165 (55%), Gaps = 8/165 (4%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL--FRRSFPLPWAIRMK 176 ++E++ L HP++++L Y E ++ L+Y +M G+L + L + PLPW IR+ Sbjct: 210 LSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIG 269 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 I +G +K + +LH VI ++NILLD ++ KL+DF +A H S Sbjct: 270 ILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHF--RSHLEHQSCT 327 Query: 357 VMGTYG------YAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRR 473 + T Y EY+ G L+ K+DVYSFG+V++E+++G R Sbjct: 328 INMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCR 372
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 91.3 bits (225), Expect = 2e-18 Identities = 58/165 (35%), Positives = 90/165 (54%), Gaps = 12/165 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP----LPWAIRMK 176 E G LQHP+++ L G C+ LV E+ G+L L R P + WA+++ Sbjct: 145 EARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQV- 203 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNIL-LDAEYN-------AKLSDFGLAKDGPEG 332 A+G+ +LH +A P+I+RD K+ NIL L+A N K++DFGLA++ + Sbjct: 204 -----ARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258 Query: 333 DKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 K + GTY + APE + + SDV+SFGV+L E+++G Sbjct: 259 TKMSAA----GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTG 299
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 91.3 bits (225), Expect = 2e-18 Identities = 56/175 (32%), Positives = 99/175 (56%), Gaps = 5/175 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF---RRSFPLPWAIRMKI 179 E+ L + H ++++++G + L+ E++ GSL N+L+ + + + A+R Sbjct: 54 EITHLSEIDHENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRW-- 111 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEY-NAKLSDFGLAKDGPEGDKTHVSTR 356 AL AK LA+LH +RP+++RD K N+LL ++ + K+ DFGLA D ++ T Sbjct: 112 ALQCAKALAYLHS-LDRPIVHRDIKPQNMLLYNQHEDLKICDFGLATD-----MSNNKTD 165 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDK-NRPNGEHNLVE 518 + GT Y APE + T+K DVYSFG++L E+M+ + PN ++ +++ Sbjct: 166 MQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMK 220
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 90.1 bits (222), Expect = 5e-18 Identities = 54/165 (32%), Positives = 89/165 (53%), Gaps = 12/165 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP----LPWAIRMK 176 E L+HP+++ L G C+++ LV EF G L L + P + WA+++ Sbjct: 191 EAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQI- 249 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYN--------AKLSDFGLAKDGPEG 332 A+G+ +LH+EA P+I+RD K+SNIL+ + K++DFGLA++ Sbjct: 250 -----ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRT 304 Query: 333 DKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 K + GTY + APE + + SDV+S+GV+L E+++G Sbjct: 305 TKMSAA----GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTG 345
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 90.1 bits (222), Expect = 5e-18 Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 14/167 (8%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP----LPWAIRMK 176 E L HP+++ L C+E+ LV E+ G L L R P + WA+++ Sbjct: 164 EARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQI- 222 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILL-------DAEYNA-KLSDFGLAKDGPEG 332 A+G+ +LH EA PVI+RD K++NILL D E+ K++DFGLA++ Sbjct: 223 -----ARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREW--- 274 Query: 333 DKTHVSTRVM--GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 H +T++ GTY + APE + + SDV+SFGV+L E+++G Sbjct: 275 ---HKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTG 318
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 90.1 bits (222), Expect = 5e-18 Identities = 48/155 (30%), Positives = 88/155 (56%), Gaps = 3/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L HP++++ +G C+ Q + E++ G+LE L + LPW +R+K+A Sbjct: 101 EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQ-LLDSNLHLPWTVRVKLAYD 159 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAE---YNAKLSDFGLAKDGPEGDKTHVSTRV 359 A GL++LH + + +RD + N L+ + Y+A ++DFGLA+ P+ V Sbjct: 160 IAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAV 216 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 +G+ + APE + K+DV+S+G++L E+++ Sbjct: 217 VGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 89.7 bits (221), Expect = 6e-18 Identities = 57/174 (32%), Positives = 93/174 (53%), Gaps = 21/174 (12%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF-------------RRSF 149 E L+HP++++L G C++ LV EF G+L L RR+ Sbjct: 171 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRAR 230 Query: 150 PLPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILL--------DAEYNAKLSDF 305 +P + + A+ A+G+ +LHEEA P+++RD K+SNILL K++DF Sbjct: 231 RIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 290 Query: 306 GLAKDGPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 GLA++ T +ST GTY + APE + + + SD++S+GV+L E+++G Sbjct: 291 GLAREWHR--TTKMST--AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTG 340
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 89.0 bits (219), Expect = 1e-17 Identities = 47/155 (30%), Positives = 88/155 (56%), Gaps = 3/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + L HP++++ +G C+ Q + E++ G+LE L + LPW +R+K+A Sbjct: 101 EMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQ-LLDSNLYLPWTVRVKLAYD 159 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAE---YNAKLSDFGLAKDGPEGDKTHVSTRV 359 A GL++LH + + +RD + N L+ + Y+A ++DFGLA+ P+ V Sbjct: 160 IAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGSEKLAV 216 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 +G+ + APE + K+DV+S+G++L E+++ Sbjct: 217 VGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 89.0 bits (219), Expect = 1e-17 Identities = 47/155 (30%), Positives = 87/155 (56%), Gaps = 3/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + L HP++++ +G C+ Q + E++ G+LE L LPW +R+K+A Sbjct: 101 EMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQ-LLDSDLYLPWTVRVKLAYD 159 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAE---YNAKLSDFGLAKDGPEGDKTHVSTRV 359 A GL++LH + + +RD + N L+ + Y+A ++DFGLA+ P+ V Sbjct: 160 IAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGREKLAV 216 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 +G+ + APE + K+DV+S+G++L E+++ Sbjct: 217 VGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 87.4 bits (215), Expect = 3e-17 Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 28/214 (13%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E + L+H +VKL+G IE+ LV E+M +G+L H+ + +P +++ +I + Sbjct: 63 EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLM-HVLKTQIDVPLSLKGRIIVE 121 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA-----------KDGPEGD 335 A +G+ +LH++ VI++D K NIL+D +++ K++D G+A KD + + Sbjct: 122 AIEGMCYLHDKG---VIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKE 178 Query: 336 KTHVSTRVM-GTYGYAAPEYV--MTGHLTSKSDVYSFGVVLLEMMSGRRSMDK------- 485 + + + GT Y APE++ + T KSDVYSFG+VL + + + + Sbjct: 179 VSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQF 238 Query: 486 -------NRPNGEHNLVEWARPYLGERRRFYRLV 566 NRPN E L R + R ++ + Sbjct: 239 VICIKSGNRPNVEEILEYCPREIISLMERCWQAI 272
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 86.7 bits (213), Expect = 5e-17 Identities = 53/158 (33%), Positives = 88/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HP++++ +G C+ Q + E+M G+LE L PL W +R+ +AL Sbjct: 100 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLE-QLLSSPEPLSWPVRLHLALD 158 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILL---DAEYNAKLSDFGLAKDGP---EGDKTHVS 350 A+GL +LH + V +RD + N L+ D + A + DFGLA+ P EG + Sbjct: 159 IARGLRYLHSKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKE-P 214 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 V+G+ + APE + K+DV++FG+VL E+++ Sbjct: 215 LAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 252
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 86.3 bits (212), Expect = 7e-17 Identities = 53/158 (33%), Positives = 88/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HP++++ +G C+ Q + E+M G+LE L PL W +R+ +AL Sbjct: 95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLE-QLLSSPEPLSWPVRLHLALD 153 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILL---DAEYNAKLSDFGLAKDGP---EGDKTHVS 350 A+GL +LH + V +RD + N L+ D + A + DFGLA+ P EG + Sbjct: 154 IAQGLRYLHAKG---VFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKE-P 209 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 V+G+ + APE + K+DV++FG+VL E+++ Sbjct: 210 LAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 247
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 86.3 bits (212), Expect = 7e-17 Identities = 53/158 (33%), Positives = 88/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HP++++ +G C+ Q + E+M G+LE L PL W +R+ +AL Sbjct: 95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLE-QLLSSPEPLSWPVRLHLALD 153 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILL---DAEYNAKLSDFGLAKDGP---EGDKTHVS 350 A+GL +LH + V +RD + N L+ D + A + DFGLA+ P EG + Sbjct: 154 IAQGLRYLHAKG---VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKE-P 209 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 V+G+ + APE + K+DV++FG+VL E+++ Sbjct: 210 LAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA 247
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 85.9 bits (211), Expect = 9e-17 Identities = 50/152 (32%), Positives = 88/152 (57%), Gaps = 1/152 (0%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS-FPLPWAIRMKIA 182 +EV L L HP++V+ + C + ++ E+M +G+L +L ++ + L +++A Sbjct: 134 SEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLA 193 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 L ++G+ +LH + VI+RD K++N+LL+ E K++DFG + + + + M Sbjct: 194 LDISRGMEYLHSQG---VIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGN---M 247 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEM 458 GTY + APE + T K DVYSFG+VL E+ Sbjct: 248 GTYRWMAPEMIKEKPYTRKVDVYSFGIVLWEL 279
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 85.1 bits (209), Expect = 2e-16 Identities = 54/155 (34%), Positives = 88/155 (56%), Gaps = 1/155 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV L NL HP++V+ +G EDD ++ EF+P GS+ + L + P P ++ Sbjct: 122 EVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISS-LLEKFGPFPESVVRTYTRQ 180 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 GL +LH A +++RD K +NIL+D + KL+DFG +K E + + GT Sbjct: 181 LLLGLEYLHNHA---IMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGT 237 Query: 369 YGYAAPEYVM-TGHLTSKSDVYSFGVVLLEMMSGR 470 + APE ++ TGH S +D++S G ++EM++G+ Sbjct: 238 PYWMAPEVILQTGHSFS-ADIWSVGCTVIEMVTGK 271
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 84.3 bits (207), Expect = 3e-16 Identities = 60/179 (33%), Positives = 90/179 (50%), Gaps = 17/179 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIE--DDQRLLVYEFMPRGSLENHLFRRSFPLPWA--IRMK 176 EV L L+HP++V+ +G C +D +V E+M GSL L L IR+K Sbjct: 1335 EVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLK 1394 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLD-------------AEYNAKLSDFGLAK 317 +AL AKG+ +LH P+++RD + NILLD + K+SDFGL++ Sbjct: 1395 LALDIAKGMNYLHGWTP-PILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSR 1453 Query: 318 DGPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRP 494 E + T+ +G Y APE + KSDVYS+G+VL E+++ +P Sbjct: 1454 LKKE--QASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKP 1510
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 84.3 bits (207), Expect = 3e-16 Identities = 53/164 (32%), Positives = 79/164 (48%), Gaps = 12/164 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLF------------RRSFP 152 E + L NLQH H+VK G C+E D ++V+E+M G L L R Sbjct: 584 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAE 643 Query: 153 LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEG 332 L + + IA A G+ +L A + ++RD T N L+ K+ DFG+++D Sbjct: 644 LTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 700 Query: 333 DKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+S GVVL E+ + Sbjct: 701 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 744
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 84.3 bits (207), Expect = 3e-16 Identities = 52/167 (31%), Positives = 92/167 (55%), Gaps = 8/167 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS-FP-LPWAIRMKIA 182 E + L + +++ ++G C E + +V E+MP GSL L R++ +P + W +R +I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRIL 125 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 A G+ +LH P+++ D KT NILLD E++ K++DFGL+K +++ S Sbjct: 126 HEIALGVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSA 184 Query: 354 RVMGTYGYAAPEYVMTG---HLTSKSDVYSFGVVLLEMMSGRRSMDK 485 GT Y PE G + K D+YS+ V++ E++S ++ ++ Sbjct: 185 PEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEE 231
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 84.3 bits (207), Expect = 3e-16 Identities = 55/167 (32%), Positives = 85/167 (50%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E + + L HP LV+L G C+E LV+EFM G L ++L + + + Sbjct: 404 IEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMC 463 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 L +G+A+L E VI+RD N L+ K+SDFG+ + + D+ ST Sbjct: 464 LDVCEGMAYLEEAC---VIHRDLAARNCLVGENQVIKVSDFGMTRFVLD-DQYTSSTGTK 519 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGE 503 +A+PE +SKSDV+SFGV++ E+ S + +NR N E Sbjct: 520 FPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE 566
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 84.0 bits (206), Expect = 3e-16 Identities = 54/157 (34%), Positives = 85/157 (54%), Gaps = 5/157 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQR--LLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E++ L NL H ++VK G C ED L+ EF+P GSL+ +L + + ++K A Sbjct: 913 EIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYA 972 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST--- 353 + KG+ +L R ++RD N+L+++E+ K+ DFGL K E DK + + Sbjct: 973 VQICKGMDYL---GSRQYVHRDLAARNVLVESEHQVKIGDFGLTK-AIETDKEYYTVKDD 1028 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 R + Y APE +M SDV+SFGV L E+++ Sbjct: 1029 RDSPVFWY-APECLMQSKFYIASDVWSFGVTLHELLT 1064 Score = 48.9 bits (115), Expect = 1e-05 Identities = 44/152 (28%), Positives = 77/152 (50%), Gaps = 9/152 (5%) Frame = +3 Query: 30 LQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAF 209 + H H+V L G C+ D + ++V EF+ G L+ + R+S L + K+A A L++ Sbjct: 633 VSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSY 692 Query: 210 LHEEAERPVIYRDFKTSNILL-----DAEYN--AKLSDFGLAKDGPEGDKTHVSTR-VMG 365 L ++ +++ + T N+LL D+E KLSD G+ T +S + + Sbjct: 693 LE---DKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGI-------PITVLSRQECIE 742 Query: 366 TYGYAAPEYVM-TGHLTSKSDVYSFGVVLLEM 458 + APE V + +L+ +D +SFG L E+ Sbjct: 743 RIPWIAPECVEDSKNLSVAADKWSFGTTLWEI 774
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 84.0 bits (206), Expect = 3e-16 Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 2/152 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF--PLPWAIRMKIA 182 EV + L+HP++V +G + +V E++ RGSL L + L R+ +A Sbjct: 596 EVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMA 655 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 AKG+ +LH P+++RD K+ N+L+D +Y K+ DFGL++ + S Sbjct: 656 YDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSR--LKASTFLSSKSAA 712 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEM 458 GT + APE + KSDVYSFGV+L E+ Sbjct: 713 GTPEWMAPEVLRDEPSNEKSDVYSFGVILWEL 744
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 83.6 bits (205), Expect = 5e-16 Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 13/165 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C+E D ++V+E+M G L N R P Sbjct: 588 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDL-NKFLRAHGPDAVLMAEGNPPT 646 Query: 153 -LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPE 329 L + + IA A G+ +L A + ++RD T N L+ K+ DFG+++D Sbjct: 647 ELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 703 Query: 330 GDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+S GVVL E+ + Sbjct: 704 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 748
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 83.6 bits (205), Expect = 5e-16 Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 13/167 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E + L+H +VKL+G IE+ + LV E+M +G+L H+ + P +++ +I L Sbjct: 63 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNL-MHVLKAEMSTPLSVKGRIILE 121 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD---GPEGDKTHVSTRV 359 +G+ +LH + VI++D K NIL+D +++ K++D GLA ++ H R Sbjct: 122 IIEGMCYLHGKG---VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELRE 178 Query: 360 M--------GTYGYAAPEYV--MTGHLTSKSDVYSFGVVLLEMMSGR 470 + GT Y APE++ + T KSDVYSF VVL + + + Sbjct: 179 VDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANK 225
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 83.6 bits (205), Expect = 5e-16 Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 13/165 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C+E D ++V+E+M G L N R P Sbjct: 587 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDL-NKFLRAHGPDAVLMAEGNPPT 645 Query: 153 -LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPE 329 L + + IA A G+ +L A + ++RD T N L+ K+ DFG+++D Sbjct: 646 ELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 702 Query: 330 GDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+S GVVL E+ + Sbjct: 703 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 747
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 83.6 bits (205), Expect = 5e-16 Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 13/165 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C+E D ++V+E+M G L N R P Sbjct: 587 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDL-NKFLRAHGPDAVLMAEGNPPT 645 Query: 153 -LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPE 329 L + + IA A G+ +L A + ++RD T N L+ K+ DFG+++D Sbjct: 646 ELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 702 Query: 330 GDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+S GVVL E+ + Sbjct: 703 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 747
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 83.2 bits (204), Expect = 6e-16 Identities = 59/164 (35%), Positives = 89/164 (54%), Gaps = 8/164 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYC--IEDDQ---RLLVYEFMPRGSLENHLFRRSFPLPWAIRM 173 EV + NL+H +++ L+G +E D LV FM GSL L + S P PW + Sbjct: 61 EVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSG-LLQPSCPRPWPLLC 119 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA--KDGPEGDKTHV 347 ++ G+ +LH +++RD K SN+LLD E +AKL+DFGL+ + G + Sbjct: 120 RLLEEVVLGMCYLHS-LNPSLLHRDLKPSNVLLDLELHAKLADFGLSTFQGGSQSGSGSG 178 Query: 348 STRVMGTYGYAAPEYV-MTGHLTSKSDVYSFGVVLLEMMSGRRS 476 S GT Y APE + G + SDVYSFGV++ +++GR + Sbjct: 179 SRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREA 222
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 82.8 bits (203), Expect = 8e-16 Identities = 54/167 (32%), Positives = 85/167 (50%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E + + L HP LV+L G C+E LV+EFM G L ++L + + + Sbjct: 409 IEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMC 468 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 L +G+A+L + VI+RD N L+ K+SDFG+ + + D+ ST Sbjct: 469 LDVCEGMAYLEKAC---VIHRDLAARNCLVGENQVIKVSDFGMTRFVLD-DQYTSSTGTK 524 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGE 503 +A+PE +SKSDV+SFGV++ E+ S + +NR N E Sbjct: 525 FPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE 571
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 82.8 bits (203), Expect = 8e-16 Identities = 62/170 (36%), Positives = 92/170 (54%), Gaps = 5/170 (2%) Frame = +3 Query: 42 HLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFLHEE 221 +++ + G C E LV E+M GSLE L S PLPW +R +I A G+ FLH Sbjct: 80 YILPVYGICREPVG--LVMEYMETGSLEKLL--ASEPLPWDLRFRIIHETAVGMNFLHCM 135 Query: 222 AERPVIYRDFKTSNILLDAEYNAKLSDFGLAK-DGPEGDKTHVSTRVMGTYGYAAPEYV- 395 A P+++ D K +NILLDA Y+ K+SDFGLAK +G + GT Y PE + Sbjct: 136 AP-PLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIR 194 Query: 396 -MTGHLTSKSDVYSFGVVLLEMMSGRRSM--DKNRPNGEHNLVEWARPYL 536 + +K DVYSF +V+ +++ ++ +KN + +V+ RP L Sbjct: 195 EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPEL 244
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 82.8 bits (203), Expect = 8e-16 Identities = 55/166 (33%), Positives = 88/166 (53%), Gaps = 7/166 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EVD L L+H ++V +G C++++ + EF+P GS+ + + R PLP + K Sbjct: 1111 EVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISS-IINRFGPLPEMVFCKYTKQ 1169 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFG----LAKDGPEGDKTHVSTR 356 +G+A+LHE V++RD K +N++L KL DFG LA G G + + Sbjct: 1170 ILQGVAYLHENC---VVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKS 1226 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR---RSMDK 485 + GT + APE + KSD++S G + EM +G+ SMD+ Sbjct: 1227 MHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDR 1272
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 82.4 bits (202), Expect = 1e-15 Identities = 54/168 (32%), Positives = 81/168 (48%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C + D ++V+E+M G L N R P Sbjct: 588 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDL-NKFLRAHGPDAMILVDGQPRQ 646 Query: 153 ----LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 L + + IA A G+ +L A + ++RD T N L+ A K+ DFG+++D Sbjct: 647 AKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRD 703 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+SFGV+L E+ + Sbjct: 704 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 751
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 82.4 bits (202), Expect = 1e-15 Identities = 54/168 (32%), Positives = 81/168 (48%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C + D ++V+E+M G L N R P Sbjct: 588 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDL-NKFLRAHGPDAMILVDGQPRQ 646 Query: 153 ----LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 L + + IA A G+ +L A + ++RD T N L+ A K+ DFG+++D Sbjct: 647 AKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRD 703 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+SFGV+L E+ + Sbjct: 704 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 751
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 82.4 bits (202), Expect = 1e-15 Identities = 54/168 (32%), Positives = 81/168 (48%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C + D ++V+E+M G L N R P Sbjct: 590 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDL-NKFLRAHGPDAMILVDGQPRQ 648 Query: 153 ----LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 L + + IA A G+ +L A + ++RD T N L+ A K+ DFG+++D Sbjct: 649 AKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRD 705 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+SFGV+L E+ + Sbjct: 706 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 753
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 82.4 bits (202), Expect = 1e-15 Identities = 53/157 (33%), Positives = 86/157 (54%), Gaps = 5/157 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQR--LLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E++ L NL H ++VK G C+ED L+ EF+P GSL+ +L + + ++K A Sbjct: 924 EIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYA 983 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST--- 353 + KG+ +L R ++RD N+L+++E+ K+ DFGL K E DK + + Sbjct: 984 IQICKGMDYL---GSRQYVHRDLAARNVLVESEHQVKIGDFGLTK-AIETDKEYYTVKDD 1039 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 R + Y APE ++ SDV+SFGV L E+++ Sbjct: 1040 RDSPVFWY-APECLIQCKFYIASDVWSFGVTLHELLT 1075 Score = 52.4 bits (124), Expect = 1e-06 Identities = 44/147 (29%), Positives = 73/147 (49%), Gaps = 4/147 (2%) Frame = +3 Query: 30 LQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAF 209 + H H+V L G C+ D + ++V EF+ G L+ + R+S L + K+A A L++ Sbjct: 644 VSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSY 703 Query: 210 LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFG-LAKDGPEGDKTHVSTR--VMGTYGYA 380 L ++ +++ + T N+LL E SD G K G V TR + + Sbjct: 704 LE---DKDLVHGNVCTKNLLLARE--GIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWI 758 Query: 381 APEYVM-TGHLTSKSDVYSFGVVLLEM 458 APE V + +L+ +D +SFG L E+ Sbjct: 759 APECVEDSKNLSVAADKWSFGTTLWEI 785
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 82.0 bits (201), Expect = 1e-15 Identities = 63/193 (32%), Positives = 93/193 (48%), Gaps = 2/193 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPL-PWAIRMKIAL 185 EV L ++HP+++ L G L+ EF GSL N L + P A M A Sbjct: 60 EVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWAR 119 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAE-YNAKLSDFGLAKDGPEGDKTHVSTRVM 362 A+GLA+LH +P+I+RD K N+LL + N K+ DFG DK+ + T Sbjct: 120 QCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTV-----ADKSTMMTNNR 174 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYLGE 542 G+ + APE T K D++S+ +VL E++S R+ K N ++W + Y GE Sbjct: 175 GSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLS-RKQPFKGIDNA--YTIQW-KIYKGE 230 Query: 543 RRRFYRLVDPRLE 581 R R+E Sbjct: 231 RPPLLTTCPKRIE 243
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 82.0 bits (201), Expect = 1e-15 Identities = 52/153 (33%), Positives = 79/153 (51%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E++ NL+H ++++L G+ ++ + L+ EF RG L HL RR+ + K Sbjct: 137 EIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHL-RRAKRFSEEVASKYIFQ 195 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A L++LH+ + VI+RD K NILL + KLSDFG + P + T + GT Sbjct: 196 MANALSYLHK---KHVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRR----TTLCGT 248 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 Y PE V T K D++S GV+ E + G Sbjct: 249 LDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVG 281
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 82.0 bits (201), Expect = 1e-15 Identities = 56/155 (36%), Positives = 83/155 (53%), Gaps = 3/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLL--VYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E+D L L H H++K G C + ++ L V E++P GSL ++L R S L A + A Sbjct: 947 EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFA 1004 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTH-VSTRV 359 +G+A+LH + I+RD N+LLD + K+ DFGLAK PEG + + V Sbjct: 1005 QQICEGMAYLHAQH---YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 1061 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + SDV+SFGV L E+++ Sbjct: 1062 DSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT 1096 Score = 42.7 bits (99), Expect = 9e-04 Identities = 42/176 (23%), Positives = 78/176 (44%), Gaps = 10/176 (5%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 + + H HL + G C+ + ++V E++ G L+ L R +P A +M +A A Sbjct: 662 MSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASA 721 Query: 201 LAFLHEEAERPVIYRDFKTSNILLD----AEYNA---KLSDFGLAKDGPEGDKTHVSTRV 359 L++L + +++ + NILL AE + KLSD G+ ++ Sbjct: 722 LSYLE---NKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREER------ 772 Query: 360 MGTYGYAAPEYVMTG--HLTSKSDVYSFGVVLLEM-MSGRRSMDKNRPNGEHNLVE 518 + + APE + G L++ D + FG LLE+ G + P+ + + + Sbjct: 773 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQ 828
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 81.3 bits (199), Expect = 2e-15 Identities = 53/167 (31%), Positives = 81/167 (48%), Gaps = 15/167 (8%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L LQH H+VK G C E D ++V+E+M G L N R P Sbjct: 543 EAELLTVLQHEHIVKFYGVCTEGDPLIMVFEYMKHGDL-NRFLRSHGPDAKILDQGQGQP 601 Query: 153 ---LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG 323 L + ++IA A G+ +L A ++RD T N L+ + K+ DFG+++D Sbjct: 602 CGQLTLSHMLQIATQIASGMVYL---ASLHFVHRDLATRNCLVGHDLVVKIGDFGMSRDI 658 Query: 324 PEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V R M + PE ++ T++SD++SFGVVL E+ + Sbjct: 659 YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFT 705
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 81.3 bits (199), Expect = 2e-15 Identities = 47/153 (30%), Positives = 84/153 (54%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E + NL +P++V ++ +DD +V E++ +L++ + + LP+ + + I + Sbjct: 58 EATAIANLSNPNVVNVLDVGTQDDINYIVMEYVEGKTLKD-IIKEKGALPYEVAISIGIK 116 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 AK L H+ +I+RD K NIL+ E K++DFG+AK H ++ VMG+ Sbjct: 117 VAKALECAHKSG---IIHRDVKPQNILVTEEGVVKVTDFGIAKSMDSSTIAHTNS-VMGS 172 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 Y +PE + ++D+YS G+VL EM++G Sbjct: 173 AHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTG 205
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 81.3 bits (199), Expect = 2e-15 Identities = 52/166 (31%), Positives = 89/166 (53%), Gaps = 8/166 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS-FP-LPWAIRMKIA 182 E + L + +++ ++G C E + +V E+MP GSL L R++ +P + W +R +I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 A G+ +LH P+++ D KT NILLD E++ K++DFGL+K ++ S Sbjct: 126 HEIALGVNYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSA 184 Query: 354 RVMGTYGYAAPEYVMTG---HLTSKSDVYSFGVVLLEMMSGRRSMD 482 GT Y PE G + K D+YS+ V+ E++S ++ + Sbjct: 185 PEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE 230
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 80.9 bits (198), Expect = 3e-15 Identities = 52/155 (33%), Positives = 87/155 (56%), Gaps = 1/155 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV L NL HP++V+ +G ED+ ++ EF+P GS+ + L + P ++ Sbjct: 121 EVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISS-LLEKFGAFPESVVRTYTNQ 179 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 GL +LH A +++RD K +NIL+D + KL+DFG +K E + + GT Sbjct: 180 LLLGLEYLHNHA---IMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGT 236 Query: 369 YGYAAPEYVM-TGHLTSKSDVYSFGVVLLEMMSGR 470 + APE ++ TGH S +D++S G ++EM++G+ Sbjct: 237 PYWMAPEVILQTGHSFS-ADIWSVGCTVIEMVTGK 270
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 80.9 bits (198), Expect = 3e-15 Identities = 53/168 (31%), Positives = 80/168 (47%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C + D ++V+E+M G L N R P Sbjct: 588 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDL-NKFLRAHGPDAMILVDGQPRQ 646 Query: 153 ----LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 L + + IA G+ +L A + ++RD T N L+ A K+ DFG+++D Sbjct: 647 AKGELGLSQMLHIASQICSGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRD 703 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+SFGV+L E+ + Sbjct: 704 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 751
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 80.5 bits (197), Expect = 4e-15 Identities = 51/167 (30%), Positives = 85/167 (50%), Gaps = 5/167 (2%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRR--SFPLPWAIRMKI 179 AE+ HP+++ ++G+C +Y +M GSL++ L + S PLPW R+ I Sbjct: 256 AELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSI 315 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSD--FGLAKDGPEGDKTHVST 353 G + +LH +I+ + K+SN+LLD KL+ L T + T Sbjct: 316 CSGLLCAVEYLHG---LEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKT 372 Query: 354 RVMGTYGYAAPE-YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNR 491 ++ T PE ++ G LT + D++S G+VL E+++G +MD NR Sbjct: 373 HLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNR 419
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 80.5 bits (197), Expect = 4e-15 Identities = 53/168 (31%), Positives = 80/168 (47%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C + D ++V+E+M G L N R P Sbjct: 588 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDL-NKFLRAHGPDAMILVDGQPXQ 646 Query: 153 ----LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 L + + IA A G+ +L A + ++RD T N + A K+ DFG+++D Sbjct: 647 AKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCXVGANLLVKIGDFGMSRD 703 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V M + PE +M T++SDV+SFGV+L E+ + Sbjct: 704 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 751
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 7/167 (4%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP-LPWAIRMKI 179 + E L+HP++V++ + + L EF+ +L + R + LP A K+ Sbjct: 55 LGEARLAAQLEHPNIVQIFDFGEAEGSFFLAMEFIDGPNLRKLVKRAAEEALPPAFCAKV 114 Query: 180 ALGAAKGLAFLHE----EAERPV--IYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKT 341 AA+GLA+ HE E P+ I+RD NIL+ + K+ DFG+AK +G +T Sbjct: 115 VAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKVVDFGIAKVAGQGHRT 174 Query: 342 HVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 V G Y PE + + + DVY+ GVVL E+++G+R D Sbjct: 175 LTGV-VKGKVAYMPPEQLQAKAMDRRVDVYALGVVLYELLTGKRPFD 220
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 80.1 bits (196), Expect = 5e-15 Identities = 55/156 (35%), Positives = 88/156 (56%), Gaps = 2/156 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIAL 185 EV L NL HP++V+ +G E D ++ EF+P GS+ + L + SFP P I L Sbjct: 121 EVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQL 180 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 GL +LH +++RD K +NIL+D + +L+DFG +K E + + + G Sbjct: 181 --LLGLEYLHNNG---IMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKG 235 Query: 366 TYGYAAPEYVM-TGHLTSKSDVYSFGVVLLEMMSGR 470 T + APE ++ TGH S +D++S G ++EM +G+ Sbjct: 236 TPYWMAPEVILQTGHSFS-ADIWSVGCTVIEMATGK 270
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 80.1 bits (196), Expect = 5e-15 Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 1/153 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL-FRRSFPLPWAIRMKIAL 185 E + L L H ++++ G +E +V E+ GSL +++ RS + M A Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWAT 112 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 AKG+ +LH EA VI+RD K+ N+++ A+ K+ DFG ++ TH+S ++G Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF--HNHTTHMS--LVG 168 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 T+ + APE + + ++ D YS+GVVL EM++ Sbjct: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT 201
>ANPRB_HUMAN (P20594) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 80.1 bits (196), Expect = 5e-15 Identities = 50/156 (32%), Positives = 82/156 (52%), Gaps = 6/156 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q HL + +G CI+ +V E+ PRGSL++ L S L W R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLIND 626 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA--KDGPEGDKTHVSTRVM 362 KG+AFLH + K+SN ++D+ + K++D+GLA + E D +H + Sbjct: 627 LVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHA---LY 681 Query: 363 GTYGYAAPEYVMTGHLTS----KSDVYSFGVVLLEM 458 + APE + L + K+DVYSFG++L E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEI 717
>ANPRB_BOVIN (P46197) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 80.1 bits (196), Expect = 5e-15 Identities = 50/156 (32%), Positives = 82/156 (52%), Gaps = 6/156 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q HL + +G CI+ +V E+ PRGSL++ L S L W R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLIND 626 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA--KDGPEGDKTHVSTRVM 362 KG+AFLH + K+SN ++D+ + K++D+GLA + E D +H + Sbjct: 627 LVKGMAFLHNSI--IASHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHA---LY 681 Query: 363 GTYGYAAPEYVMTGHLTS----KSDVYSFGVVLLEM 458 + APE + L + K+DVYSFG++L E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEI 717
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 79.7 bits (195), Expect = 7e-15 Identities = 65/192 (33%), Positives = 100/192 (52%), Gaps = 14/192 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQ------RLLVYEFMPRGSLENHLFRRSFPLPWAIR 170 EV + NL++ +++ L+G ED Q + LV FM GSL L + P PW + Sbjct: 61 EVKAMVNLRNENVLLLLGVT-EDLQWDFVSGQALVTRFMENGSLAG-LLQPECPRPWPLL 118 Query: 171 MKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKT 341 ++ G+ +LH + P+++RD K SNILLD E +AKL+DFGL+ G + Sbjct: 119 CRLLQEVVLGMCYLHS-LDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGS 177 Query: 342 HVSTRVM-GTYGYAAPEYVMTGHL--TSKSDVYSFGVVLLEMMSGRRS--MDKNRPNGEH 506 +R GT Y PE + +L + SDVYSFG+++ +++GR + +DK E Sbjct: 178 GSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRET 237 Query: 507 NLVEWARPYLGE 542 +RP L E Sbjct: 238 VCDRQSRPPLTE 249
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 79.7 bits (195), Expect = 7e-15 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 4/165 (2%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPW---AIRM 173 + E+ L + HP++VKL G C+ + LV E+ GSL N L PLP+ A M Sbjct: 75 IVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAE-PLPYYTAAHAM 131 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNA-KLSDFGLAKDGPEGDKTHVS 350 L ++G+A+LH + +I+RD K N+LL A K+ DFG A D +TH+ Sbjct: 132 SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACD----IQTHM- 186 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDK 485 T G+ + APE + + K DV+S+G++L E+++ R+ D+ Sbjct: 187 TNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDE 231
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 79.7 bits (195), Expect = 7e-15 Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 1/153 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL-FRRSFPLPWAIRMKIAL 185 E + L L H ++++ G +E +V E+ GSL +++ RS + M A Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 AKG+ +LH EA VI+RD K+ N+++ A+ K+ DFG ++ TH+S ++G Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF--HNHTTHMS--LVG 168 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 T+ + APE + + ++ D YS+GVVL EM++ Sbjct: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT 201
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 79.7 bits (195), Expect = 7e-15 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 4/165 (2%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPW---AIRM 173 + E+ L + HP++VKL G C+ + LV E+ GSL N L PLP+ A M Sbjct: 75 IVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAE-PLPYYTAAHAM 131 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNA-KLSDFGLAKDGPEGDKTHVS 350 L ++G+A+LH + +I+RD K N+LL A K+ DFG A D +TH+ Sbjct: 132 SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACD----IQTHM- 186 Query: 351 TRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDK 485 T G+ + APE + + K DV+S+G++L E+++ R+ D+ Sbjct: 187 TNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDE 231
>LRRK1_MOUSE (Q3UHC2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2014 Score = 79.3 bits (194), Expect = 9e-15 Identities = 68/199 (34%), Positives = 98/199 (49%), Gaps = 14/199 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS-----FPLPWAIRM 173 E L LQHP +V L+G I E P GSL L + PL + Sbjct: 1307 EASMLHALQHPCIVSLIGISIHP--LCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQ 1364 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILL-----DAEYNAKLSDFGLAKDG-PEGD 335 KIA A GLA+LH+ + +I+ D K+ NIL+ N KLSD+G+++ EG Sbjct: 1365 KIAYQIASGLAYLHK---KNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHEG- 1420 Query: 336 KTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRR-SMDKNRPNGEHNL 512 + V GT GY APE K D++S+G+VL E++SG+R ++ ++ L Sbjct: 1421 ----ALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKL 1476 Query: 513 VEWARPYLG--ERRRFYRL 563 + RP LG E +F+RL Sbjct: 1477 SKGIRPVLGQPEEVQFHRL 1495
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 79.3 bits (194), Expect = 9e-15 Identities = 53/161 (32%), Positives = 89/161 (55%), Gaps = 7/161 (4%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIE--DDQRLLVYEFMPRGSLENHLFR---RSFPLPWAI 167 V E + L+H +V+L+G C E D L++ E+M GSL+ +L + L + Sbjct: 261 VLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMV 320 Query: 168 RMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK--DGPEGDKT 341 M + ++G+A+L E V++RD + NIL+ + K++DFGL + DG GD+ Sbjct: 321 HMMAEI--SEGMAYLESEK---VVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQE 375 Query: 342 HVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + R Y + APE + TSKSDV+S+G+V+ E+++ Sbjct: 376 KKTLRF--PYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILT 414
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 79.3 bits (194), Expect = 9e-15 Identities = 49/158 (31%), Positives = 81/158 (51%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E +L HP++V + EDD +V E++ +L+ ++ PL + I Sbjct: 59 EAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANG-PLHPKEALNIMEQ 117 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 +A H+ +++RD K NIL+D N K++DFG+A TH ++ V+G+ Sbjct: 118 IVSAIAHAHQNQ---IVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHTNS-VLGS 173 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 Y +PE G T KSD+Y+ G+VL E+++GR D Sbjct: 174 VHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFD 211
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 79.0 bits (193), Expect = 1e-14 Identities = 56/154 (36%), Positives = 81/154 (52%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L + HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 109 ERDILAEVNHPFIVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 166 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A L LH +IYRD K NILLD E + K++DFGL+K+ + DK S G Sbjct: 167 ELALALDHLHGLG---IIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYS--FCG 221 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V T +D +SFGV++ EM++G Sbjct: 222 TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 255 Score = 45.8 bits (107), Expect = 1e-04 Identities = 44/150 (29%), Positives = 71/150 (47%), Gaps = 5/150 (3%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAAKGLAF 209 QHP+++ L + LV E M G L + + R R F A + + A+ + + Sbjct: 465 QHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTI--ARTMDY 522 Query: 210 LHEEAERPVIYRDFKTSNIL-LDAEYNA---KLSDFGLAKDGPEGDKTHVSTRVMGTYGY 377 LH + V++RD K SNIL +D N ++ DFG AK + + T T + Sbjct: 523 LHSQG---VVHRDLKPSNILYMDESGNPESIRICDFGFAKQ-LRAENGLLMTPCY-TANF 577 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + + DV+S G++L M++G Sbjct: 578 VAPEVLKRQGYDAACDVWSLGILLYTMLAG 607
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 79.0 bits (193), Expect = 1e-14 Identities = 56/154 (36%), Positives = 81/154 (52%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L + HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 109 ERDILAEVNHPFIVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 166 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A L LH +IYRD K NILLD E + K++DFGL+K+ + DK S G Sbjct: 167 ELALALDHLHSLG---IIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYS--FCG 221 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V T +D +SFGV++ EM++G Sbjct: 222 TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 255 Score = 47.8 bits (112), Expect = 3e-05 Identities = 39/149 (26%), Positives = 68/149 (45%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + LV E M G L + + R+ + + K + +L Sbjct: 465 QHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRY-FSEREASDVLCTITKTMDYL 523 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNA----KLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL E + ++ DFG AK G+ ++ T + Sbjct: 524 HSQG---VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTP--CYTANFV 578 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + + D++S G++L M++G Sbjct: 579 APEVLKRQGYDAACDIWSLGILLYTMLAG 607
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 79.0 bits (193), Expect = 1e-14 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L ++ HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 112 ERDILADVNHPFVVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 169 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A GL LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 170 ELALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V T +D +S+GV++ EM++G Sbjct: 225 TVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTG 258 Score = 46.2 bits (108), Expect = 8e-05 Identities = 42/149 (28%), Positives = 68/149 (45%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + LV E M G L + + R+ F + +K + +L Sbjct: 468 QHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASF-VLYTISKTVEYL 526 Query: 213 HEEAERPVIYRDFKTSNIL-LDAEYN---AKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL +D N ++ DFG AK + + T T + Sbjct: 527 HSQG---VVHRDLKPSNILYVDESGNPECLRICDFGFAKQ-LRAENGLLMTPCY-TANFV 581 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + D++S GV+L M++G Sbjct: 582 APEVLKRQGYDEGCDIWSLGVLLYTMLAG 610
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/149 (37%), Positives = 77/149 (51%), Gaps = 5/149 (3%) Frame = +3 Query: 39 PHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL-----FRRSFPLPWAIRMKIALGAAKGL 203 P LV + D+ V E+ G L H+ F+ S + +A+ + IAL Sbjct: 430 PFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIAL------ 483 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYAA 383 FLHE R +IYRD K NILLD E + KL DFGL+K+G +T + GT Y A Sbjct: 484 FFLHE---RDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQT--TRTFCGTPNYMA 538 Query: 384 PEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 PE V + +D +SFGV+L E M+G+ Sbjct: 539 PEIVSYDPYSIAADWWSFGVLLFEFMAGQ 567
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 78.6 bits (192), Expect = 1e-14 Identities = 53/157 (33%), Positives = 82/157 (52%), Gaps = 12/157 (7%) Frame = +3 Query: 30 LQHPHLVKLVGY---CIEDD--QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAA 194 L+HPH+V++V C D ++ E+ G+L ++ RS PL I M+ A A Sbjct: 115 LRHPHVVRVVAASASCPGDPGCPGTIIMEYTGTGTLHQRIYGRSPPLGAEICMRYARHVA 174 Query: 195 KGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST------- 353 GL FLH + V++ D K +N+LL K+ DFG ++ EGD+ Sbjct: 175 DGLRFLHRDG---VVHLDLKPANVLLAPGDLCKIGDFGCSQRLREGDEAAGGEPCCTQLR 231 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 V GTY + APE + +T+K+D+YSF + L +M+S Sbjct: 232 HVGGTYTHRAPELLKGEPVTAKADIYSFAITLWQMVS 268
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 78.6 bits (192), Expect = 1e-14 Identities = 55/155 (35%), Positives = 82/155 (52%), Gaps = 3/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL--LVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E++ L L H H+VK G C + ++ LV E++P GSL ++L R L A + A Sbjct: 940 EIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGL--AQLLLFA 997 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTH-VSTRV 359 +G+A+LH + I+RD N+LLD + K+ DFGLAK PEG + + V Sbjct: 998 QQICEGMAYLHAQH---YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 1054 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + SDV+SFGV L E+++ Sbjct: 1055 DSPVFWYAPECLKECKFYYASDVWSFGVTLYELLT 1089 Score = 50.8 bits (120), Expect = 3e-06 Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 14/204 (6%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 + + H HL L G C+ + ++V EF+ G L+ L R+ +P +M +A A Sbjct: 655 MSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASA 714 Query: 201 LAFLHEE--AERPVIYRDFKTSNILLDAEYN--AKLSDFGLAKDGPEGDKTHVSTRVMGT 368 L++L ++ V R+ + + L+ N KLSD G+ + ++ + Sbjct: 715 LSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREER------VER 768 Query: 369 YGYAAPEYVM--TGHLTSKSDVYSFGVVLLEM-------MSGRRSMDKNR-PNGEHNLVE 518 + APE + T L + +D++ FG LLE+ + GR +K R +H L E Sbjct: 769 IPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPE 828 Query: 519 WARPYLGERRRFYRLVDPRLEGNF 590 + P L R +P +F Sbjct: 829 PSCPELATLTRQCLTYEPAQRPSF 852
>PKN3_HUMAN (Q6P5Z2) Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein| kinase PKN-beta) (Protein-kinase C-related kinase 3) Length = 889 Score = 78.2 bits (191), Expect = 2e-14 Identities = 56/153 (36%), Positives = 78/153 (50%), Gaps = 1/153 (0%) Frame = +3 Query: 12 VDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGA 191 ++ +G HP L+ L+ V EF+P G L + FP P A R +A Sbjct: 611 LEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQA-RFYVAC-V 668 Query: 192 AKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGT 368 GL FLHE + +IYRD K N+LLDA+ K++DFGL K+G GD+T + GT Sbjct: 669 VLGLQFLHE---KKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRT---STFCGT 722 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + T D + GV+L EM+ G Sbjct: 723 PEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVG 755
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 78.2 bits (191), Expect = 2e-14 Identities = 51/155 (32%), Positives = 89/155 (57%), Gaps = 2/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIED-DQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 EV L L HP +V+ VG C++D Q +V +++ GSL + L + L ++ IA+ Sbjct: 508 EVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAV 567 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 AKG+ +LH + P+I+RD + NILL + +A ++DFG ++ D+ ++ T+ G Sbjct: 568 DVAKGMEYLHSLTQ-PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNM-TKQPG 625 Query: 366 TYGYAAPE-YVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + T K+DV+S+ + L E+++G Sbjct: 626 NLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLTG 660
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 78.2 bits (191), Expect = 2e-14 Identities = 53/162 (32%), Positives = 86/162 (53%), Gaps = 8/162 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCI-----EDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRM 173 EV + +L + +++L G +D + LV +FM GSL L + P PW + Sbjct: 60 EVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSG-LLQSQCPRPWPLLC 118 Query: 174 KIALGAAKGLAFLHEEAERPVI-YRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVS 350 ++ G+ +LH++ PV+ +RD K SN+L D E + KL+DFGL+ S Sbjct: 119 RLLKEVVLGMFYLHDQ--NPVLLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQSGTGS 176 Query: 351 TRVMGTYGYAAPEYVMTGH--LTSKSDVYSFGVVLLEMMSGR 470 GT GY APE + + ++ SDVYSFG+++ +++GR Sbjct: 177 GEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGR 218
>ANPRB_RAT (P16067) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 77.8 bits (190), Expect = 2e-14 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 6/156 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q HL + +G CI+ +V E+ PRGSL++ L S L W R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLIND 626 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA--KDGPEGDKTHVSTRVM 362 KG+AFLH + K+SN ++D+ + K++D+GLA + E D +H + Sbjct: 627 LVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHA---LY 681 Query: 363 GTYGYAAPEYVMTGHLTS----KSDVYSFGVVLLEM 458 + APE + L + K+DVYSF ++L E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEI 717
>ANPRB_MOUSE (Q6VVW5) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 77.8 bits (190), Expect = 2e-14 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 6/156 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q HL + +G CI+ +V E+ PRGSL++ L S L W R + Sbjct: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLIND 626 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA--KDGPEGDKTHVSTRVM 362 KG+AFLH + K+SN ++D+ + K++D+GLA + E D +H + Sbjct: 627 LVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHA---LY 681 Query: 363 GTYGYAAPEYVMTGHLTS----KSDVYSFGVVLLEM 458 + APE + L + K+DVYSF ++L E+ Sbjct: 682 AKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEI 717
>PKN3_MOUSE (Q8K045) Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein| kinase PKN-beta) (Protein-kinase C-related kinase 3) Length = 878 Score = 77.8 bits (190), Expect = 2e-14 Identities = 54/153 (35%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Frame = +3 Query: 12 VDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGA 191 ++ +G HP L+ L+ V EF+P G L + FP P A + Sbjct: 600 LETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVFPEPQACFYLACV-- 657 Query: 192 AKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGT 368 GL FLHE+ +IYRD K N+LLDA+ K++DFGL K+G GD+T + GT Sbjct: 658 VLGLQFLHEKR---IIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRT---STFCGT 711 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + T D + GV+L EM+ G Sbjct: 712 PEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVG 744
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 77.8 bits (190), Expect = 2e-14 Identities = 50/149 (33%), Positives = 77/149 (51%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 L + HP ++++ G + Q +V +++ G L + L R+S P + A Sbjct: 140 LSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFS-LLRKSQRFPNPVAKFYAAEVCLA 198 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 L +LH + +IYRD K NILLD + K++DFG AK P+ V+ + GT Y Sbjct: 199 LEYLHS---KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD-----VTYTLCGTPDYI 250 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE V T D +SFGV++ EM++G Sbjct: 251 APEVVSTKPYNKSVDWWSFGVLIYEMLAG 279
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 77.4 bits (189), Expect = 3e-14 Identities = 55/154 (35%), Positives = 83/154 (53%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L ++ HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 130 ERDILADVNHPFVVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 187 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A GL LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 188 ELALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 242 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V + +D +S+GV++ EM++G Sbjct: 243 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTG 276 Score = 45.4 bits (106), Expect = 1e-04 Identities = 41/149 (27%), Positives = 66/149 (44%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + LV E M G L + + R+ F + K + +L Sbjct: 485 QHPNIITLKDVYDDGKYVYLVTELMRGGELLDKILRQKF-FSEREASSVLHTICKTVEYL 543 Query: 213 HEEAERPVIYRDFKTSNILLDAE----YNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL E + ++ DFG AK + + T T + Sbjct: 544 HSQG---VVHRDLKPSNILYVDESGNPESIRICDFGFAKQ-LRAENGLLMTPCY-TANFV 598 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + D++S GV+L M++G Sbjct: 599 APEVLKRQGYDEGCDIWSLGVLLYTMLAG 627
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 77.4 bits (189), Expect = 3e-14 Identities = 55/154 (35%), Positives = 83/154 (53%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L ++ HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 112 ERDILADVNHPFVVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 169 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A GL LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 170 ELALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V + +D +S+GV++ EM++G Sbjct: 225 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTG 258 Score = 44.3 bits (103), Expect = 3e-04 Identities = 41/149 (27%), Positives = 67/149 (44%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + LV E M G L + + R+ F + K + +L Sbjct: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHT-IGKTVEYL 526 Query: 213 HEEAERPVIYRDFKTSNIL-LDAEYN---AKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL +D N ++ DFG AK + + T T + Sbjct: 527 HSQG---VVHRDLKPSNILYVDESGNPECLRICDFGFAKQ-LRAENGLLMTPCY-TANFV 581 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + D++S G++L M++G Sbjct: 582 APEVLKRQGYDEGCDIWSLGILLYTMLAG 610
>ANPRB_ANGJA (P55202) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1050 Score = 77.4 bits (189), Expect = 3e-14 Identities = 48/156 (30%), Positives = 81/156 (51%), Gaps = 6/156 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q HL + +G CI+ +V E+ PRGSL++ L S L W R + Sbjct: 571 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLIND 630 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA--KDGPEGDKTHVSTRVM 362 KG+ FLH + + K+SN ++D+ + K++D+GLA + E + +H + Sbjct: 631 IVKGMNFLHNSYIGS--HGNLKSSNCVVDSRFVLKITDYGLASFRSSCENEDSHA---LY 685 Query: 363 GTYGYAAPEYVMTGHL----TSKSDVYSFGVVLLEM 458 + APE ++ T K DVYSFG++L E+ Sbjct: 686 AKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEI 721
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 77.4 bits (189), Expect = 3e-14 Identities = 46/148 (31%), Positives = 81/148 (54%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 L HP++VKL+G C++ ++V E + GSL +L + S L +M + AA G Sbjct: 1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAG 1172 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 + +L + I+RD N L+D E++ K+SDFG++++ E + ++ + Sbjct: 1173 MRYLE---SKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQI--PVKWT 1227 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMS 464 APE + G TS DV+S+G+++ E+ S Sbjct: 1228 APEALNFGKYTSLCDVWSYGILMWEIFS 1255
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 77.0 bits (188), Expect = 4e-14 Identities = 51/155 (32%), Positives = 88/155 (56%), Gaps = 2/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIED-DQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 EV L L HP +V+ VG C++D Q +V +++ GSL + L + L ++ IA+ Sbjct: 507 EVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAV 566 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 AKG+ +LH + P+I+RD + NILL + +A ++DFG ++ D+ ++ T+ G Sbjct: 567 DVAKGMEYLHSLTQ-PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNM-TKQPG 624 Query: 366 TYGYAAPE-YVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + T K+DV+S+ + L E++ G Sbjct: 625 NLRWMAPEVFTQCTRYTIKADVFSYALCLWELLIG 659
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 77.0 bits (188), Expect = 4e-14 Identities = 47/153 (30%), Positives = 78/153 (50%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV+ +L+HP+L +L GY ++ + L+ E++ G L HL RS + Sbjct: 157 EVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSH-FNDVVASYYVYQ 215 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A L ++H ER +++RD K NI++ KL+DFG + P+G K + GT Sbjct: 216 MADALDYMH---ERNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSKRKT---LCGT 269 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 Y +PE + + K DV++ GV+ E++ G Sbjct: 270 VDYLSPELIRSREYNEKVDVWALGVLTYELLVG 302
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 77.0 bits (188), Expect = 4e-14 Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 4/156 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQR--LLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E++ L +LQH ++VK G C +R L+ E++P GSL ++L + + ++ Sbjct: 898 EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYT 957 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 KG+ +L + I+RD T NIL++ E K+ DFGL K P+ DK + + Sbjct: 958 SQICKGMEYL---GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEYYKVKEP 1013 Query: 363 G--TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + + SDV+SFGVVL E+ + Sbjct: 1014 GESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 1049 Score = 53.9 bits (128), Expect = 4e-07 Identities = 46/153 (30%), Positives = 73/153 (47%), Gaps = 4/153 (2%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 + L H HLV G C+ ++ +LV EF+ GSL+ +L + +I + LG AK Sbjct: 601 MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKN----SINILWKLGVAKQ 656 Query: 201 LAF-LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR--VMGTY 371 LA+ +H E+ +I+ + NILL E + K + K G V + + Sbjct: 657 LAWAMHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI 716 Query: 372 GYAAPEYVMT-GHLTSKSDVYSFGVVLLEMMSG 467 + PE + +LT +D +SFG L E+ SG Sbjct: 717 PWVPPECIENPKNLTLATDKWSFGTTLWEICSG 749
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 77.0 bits (188), Expect = 4e-14 Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 4/156 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQR--LLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E++ L +LQH ++VK G C +R L+ E++P GSL ++L + + ++ Sbjct: 898 EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYT 957 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 KG+ +L + I+RD T NIL++ E K+ DFGL K P+ DK + + Sbjct: 958 SQICKGMEYL---GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEYYKVKEP 1013 Query: 363 G--TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + + SDV+SFGVVL E+ + Sbjct: 1014 GESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 1049 Score = 50.1 bits (118), Expect = 6e-06 Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 3/152 (1%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 + L H HLV G C+ D+ +LV EF+ GSL+ +L + + ++++A A Sbjct: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA 660 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR--VMGTYG 374 + FL E +I+ + NILL E + K + K G V + + Sbjct: 661 MHFLEENT---LIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP 717 Query: 375 YAAPEYVMT-GHLTSKSDVYSFGVVLLEMMSG 467 + PE + +L +D +SFG L E+ SG Sbjct: 718 WVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 77.0 bits (188), Expect = 4e-14 Identities = 56/154 (36%), Positives = 81/154 (52%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L + HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 118 ERDILVEVNHPFIVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 175 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A L LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 176 ELALALDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYS--FCG 230 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V T +D +SFGV++ EM++G Sbjct: 231 TVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 264 Score = 45.8 bits (107), Expect = 1e-04 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + +V E M G L + + R+ F + K + +L Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF-FSEREASAVLFTITKTVEYL 530 Query: 213 HEEAERPVIYRDFKTSNILLDAE----YNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL E + ++ DFG AK + + T T + Sbjct: 531 HAQG---VVHRDLKPSNILYVDESGNPESIRICDFGFAKQ-LRAENGLLMTPCY-TANFV 585 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + + D++S GV+L M++G Sbjct: 586 APEVLKRQGYDAACDIWSLGVLLYTMLTG 614
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 77.0 bits (188), Expect = 4e-14 Identities = 56/154 (36%), Positives = 81/154 (52%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L + HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 118 ERDILVEVNHPFIVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 175 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A L LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 176 ELALALDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYS--FCG 230 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V T +D +SFGV++ EM++G Sbjct: 231 TVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 264 Score = 45.8 bits (107), Expect = 1e-04 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + +V E M G L + + R+ F + K + +L Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF-FSEREASAVLFTITKTVEYL 530 Query: 213 HEEAERPVIYRDFKTSNILLDAE----YNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL E + ++ DFG AK + + T T + Sbjct: 531 HAQG---VVHRDLKPSNILYVDESGNPESIRICDFGFAKQ-LRAENGLLMTPCY-TANFV 585 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + + D++S GV+L M++G Sbjct: 586 APEVLKRQGYDAACDIWSLGVLLYTMLTG 614
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 76.6 bits (187), Expect = 6e-14 Identities = 46/157 (29%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++++L G + ++V E+M GSL++ L + + + Sbjct: 668 LGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 727 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 728 RGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 784 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + +PE + TS SDV+S+G+VL E+MS Sbjct: 785 KI--PIRWTSPEAMSYRKFTSASDVWSYGIVLWEVMS 819
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 76.6 bits (187), Expect = 6e-14 Identities = 47/153 (30%), Positives = 84/153 (54%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 ++ L L+HP+++ G C + ++ EF +G L L R P+ ++ + ++G Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL-RAGRPVTPSLLVDWSMG 219 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+ +LH +I+RD K+ N+L+ + K+SDFG +K+ DK+ GT Sbjct: 220 IAGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTSKE--LSDKS-TKMSFAGT 273 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + ++ K D++SFGVVL E+++G Sbjct: 274 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 306
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 76.6 bits (187), Expect = 6e-14 Identities = 50/155 (32%), Positives = 88/155 (56%), Gaps = 2/155 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIED-DQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 EV L L HP +++ VG C+ D Q +V +++ GSL + L + L ++ IA+ Sbjct: 610 EVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAV 669 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 AKG+ +LH + P+I+RD + NILL + +A ++DFG ++ D+ ++ T+ G Sbjct: 670 DVAKGMEYLHNLTQ-PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNM-TKQPG 727 Query: 366 TYGYAAPE-YVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + T K+DV+S+ + L E+++G Sbjct: 728 NLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTG 762
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 76.6 bits (187), Expect = 6e-14 Identities = 54/171 (31%), Positives = 86/171 (50%), Gaps = 13/171 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HP+++K +G +D + + E++ G+L + PW+ R+ A Sbjct: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 443 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA------KDGPEG------ 332 A G+A+LH +I+RD + N L+ N ++DFGLA K PEG Sbjct: 444 IASGMAYLH---SMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKK 500 Query: 333 -DKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 D+ T V+G + APE + K DV+SFG+VL E++ GR + D Sbjct: 501 PDRKKRYT-VVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 76.6 bits (187), Expect = 6e-14 Identities = 47/153 (30%), Positives = 84/153 (54%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 ++ L L+HP+++ G C + ++ EF +G L L R P+ ++ + ++G Sbjct: 194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL-RAGRPVTPSLLVDWSMG 252 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+ +LH +I+RD K+ N+L+ + K+SDFG +K+ DK+ GT Sbjct: 253 IAGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTSKE--LSDKS-TKMSFAGT 306 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + ++ K D++SFGVVL E+++G Sbjct: 307 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 339
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 76.6 bits (187), Expect = 6e-14 Identities = 47/153 (30%), Positives = 84/153 (54%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 ++ L L+HP+++ G C + ++ EF +G L L R P+ ++ + ++G Sbjct: 194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL-RAGRPVTPSLLVDWSMG 252 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+ +LH +I+RD K+ N+L+ + K+SDFG +K+ DK+ GT Sbjct: 253 IAGGMNYLHLHK---IIHRDLKSPNMLITYDDVVKISDFGTSKE--LSDKS-TKMSFAGT 306 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + ++ K D++SFGVVL E+++G Sbjct: 307 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 339
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 76.6 bits (187), Expect = 6e-14 Identities = 48/149 (32%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGVVL E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVVLWELMT 1278
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 76.6 bits (187), Expect = 6e-14 Identities = 58/184 (31%), Positives = 91/184 (49%), Gaps = 10/184 (5%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ +L L+HPH++KL D+ ++V EF + + + R P A R + Sbjct: 100 EISYLRLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIVQRGKMPEDEARRFFQQII 159 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 AA H+ +++RD K N+LLD + N K++DFGL+ +G+ S G+ Sbjct: 160 AAVEYCHRHK-----IVHRDLKPENLLLDDQLNVKIADFGLSNIMTDGNFLKTS---CGS 211 Query: 369 YGYAAPEYVMTGHLTS--KSDVYSFGVVLLEMMSGRRSMD--------KNRPNGEHNLVE 518 YAAPE V++G L + + DV+S GV+L M+ GR D K NG + L Sbjct: 212 PNYAAPE-VISGKLYAGPEVDVWSSGVILYVMLCGRLPFDDEFIPALFKKISNGVYTLPN 270 Query: 519 WARP 530 + P Sbjct: 271 YLSP 274
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 76.3 bits (186), Expect = 7e-14 Identities = 46/157 (29%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++++L G + ++V E+M GSL++ L + + + Sbjct: 668 LGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 727 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 728 RGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 784 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + +PE + TS SDV+S+G+VL E+MS Sbjct: 785 KI--PIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMS 819
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 76.3 bits (186), Expect = 7e-14 Identities = 54/154 (35%), Positives = 83/154 (53%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L ++ HP +V+L Y + + +L L+ +F+ G L L + ++ +A Sbjct: 112 ERDILADVHHPFVVRL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 169 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A GL LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 170 ELALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V + +D +S+GV++ EM++G Sbjct: 225 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTG 258 Score = 47.4 bits (111), Expect = 4e-05 Identities = 41/149 (27%), Positives = 66/149 (44%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L E + +V E M G L + + R+ F + K + L Sbjct: 466 QHPNIIALKDVYKEGNSIYVVTELMRGGELLDRILRQKF-FSEREASSVLFTVCKTVENL 524 Query: 213 HEEAERPVIYRDFKTSNILLDAE----YNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL E + ++ DFG AK D + T T + Sbjct: 525 HSQG---VVHRDLKPSNILYVDESGDPESIRICDFGFAKQ-LRADNGLLMTPCY-TANFV 579 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + D++S G++L M++G Sbjct: 580 APEVLKRQGYDEGCDIWSLGILLYTMLAG 608
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 76.3 bits (186), Expect = 7e-14 Identities = 49/156 (31%), Positives = 80/156 (51%), Gaps = 1/156 (0%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLV-GYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKI 179 + E+ + + QH ++V + Y I D++ ++ E+M GSL + F L I Sbjct: 724 INEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATI 783 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 KGL LH+ + +I+RD K+ N+LLDA N K++DFG D+ + + Sbjct: 784 CFETLKGLQHLHK---KHIIHRDIKSDNVLLDAYGNVKITDFGFC--AKLTDQRNKRATM 838 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 +GT + APE V K DV+S G++ +EM+ G Sbjct: 839 VGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEG 874
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 75.9 bits (185), Expect = 9e-14 Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 9/163 (5%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHL---FRRSFPLPWAIRM 173 + E +G HP++++L+G + ++V E+M GSL+ L +R + W Sbjct: 763 LTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKIT 822 Query: 174 KIALGAAKGLAFLHE--EAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK----DGPEGD 335 ++ G A G+ +L + R RD N+LLD E K++DFGL++ +G + Sbjct: 823 EMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVE 882 Query: 336 KTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + + + APE + T SDV+SFGVV+ E+ S Sbjct: 883 PEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCS 925
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 75.9 bits (185), Expect = 9e-14 Identities = 48/149 (32%), Positives = 77/149 (51%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 L + HP ++++ G + Q ++ +++ G L + L R+S P + A Sbjct: 139 LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFS-LLRKSQRFPNPVAKFYAAEVCLA 197 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 L +LH + +IYRD K NILLD + K++DFG AK P+ V+ + GT Y Sbjct: 198 LEYLHS---KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD-----VTYTLCGTPDYI 249 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE V T D +SFG+++ EM++G Sbjct: 250 APEVVSTKPYNKSIDWWSFGILIYEMLAG 278
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 75.9 bits (185), Expect = 9e-14 Identities = 50/156 (32%), Positives = 82/156 (52%), Gaps = 4/156 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQR--LLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 E++ L +LQH ++VK G C +R L+ E++P GSL ++L + + ++ Sbjct: 898 EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYT 957 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 KG+ +L + I+RD T NIL++ E K+ DFGL K P+ DK + + Sbjct: 958 SQICKGMEYL---GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEYYKVKEP 1013 Query: 363 G--TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + AP+ + + SDV+SFGVVL E+ + Sbjct: 1014 GESPIFWYAPQSLTESKFSVASDVWSFGVVLYELFT 1049 Score = 50.8 bits (120), Expect = 3e-06 Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 4/153 (2%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 + L H HLV G C+ ++ +LV EF+ GSL+ +L + +I + LG AK Sbjct: 601 MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKN----SINILWKLGVAKQ 656 Query: 201 LAF-LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR--VMGTY 371 LA+ +H E+ +I+ + NILL E + + + K G V + + Sbjct: 657 LAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERI 716 Query: 372 GYAAPEYVMT-GHLTSKSDVYSFGVVLLEMMSG 467 + PE + +L +D +SFG L E+ SG Sbjct: 717 PWVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
>KPCZ_RABIT (O19111) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 591 Score = 75.9 bits (185), Expect = 9e-14 Identities = 59/164 (35%), Positives = 83/164 (50%), Gaps = 2/164 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 +P LV L C + RL LV E++ G L H+ +R LP A L FL Sbjct: 309 NPFLVGLHS-CFQTTSRLFLVIEYVNGGDLMFHM-QRQRKLPEEHARFYAAEICIALNFL 366 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLDA+ + KL+D+G+ K+G GD T + GT Y APE Sbjct: 367 HE---RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT---STFCGTPNYIAPE 420 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEW 521 + D ++ GV++ EMM+GR D N + N ++ Sbjct: 421 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDY 464
>LRRK1_HUMAN (Q38SD2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2038 Score = 75.9 bits (185), Expect = 9e-14 Identities = 69/199 (34%), Positives = 98/199 (49%), Gaps = 14/199 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS-----FPLPWAIRM 173 E L LQHP +V L+G I E P SL L + PL + Sbjct: 1330 EASMLHALQHPCIVALIGISIHP--LCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQ 1387 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNIL---LDAE--YNAKLSDFGLAKDG-PEGD 335 KIA A GLA+LH+ + +I+ D K+ NIL LD + N KLSD+G+++ EG Sbjct: 1388 KIAYQIASGLAYLHK---KNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEG- 1443 Query: 336 KTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRR-SMDKNRPNGEHNL 512 + V GT GY APE K D++S+G+VL E++SG+R ++ ++ L Sbjct: 1444 ----ALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKL 1499 Query: 513 VEWARPYLG--ERRRFYRL 563 + RP LG E +F RL Sbjct: 1500 SKGIRPVLGQPEEVQFRRL 1518
>KPC3_CAEEL (Q19266) Protein kinase C-like 3 (EC 2.7.11.13) (Atypical protein| kinase C-3) (aPKC3) Length = 597 Score = 75.9 bits (185), Expect = 9e-14 Identities = 63/187 (33%), Positives = 92/187 (49%), Gaps = 4/187 (2%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLL-VYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 +P LV L C + + RL V EF+P G L H+ ++ LP + L FL Sbjct: 311 YPFLVGLHS-CFQTESRLFFVIEFVPGGDLMFHM-QQQRKLPEEHARFYSGEIILALHFL 368 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 H R +IYRD K N+L+DAE + KL+D+G+ K+ +GD T + GT Y APE Sbjct: 369 HS---RGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIKDGDLT---STFCGTPNYIAPE 422 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD-KNRPNGEHNLVEWARPYLGERR-RFYRL 563 + D ++ GV++ EMM+GR D N E N ++ + ER+ R R Sbjct: 423 ILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQNSEENTEDYLFQIILERQIRIPRS 482 Query: 564 VDPRLEG 584 + R G Sbjct: 483 LSVRASG 489
>KPCZ_RAT (P09217) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 75.9 bits (185), Expect = 9e-14 Identities = 59/164 (35%), Positives = 83/164 (50%), Gaps = 2/164 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 +P LV L C + RL LV E++ G L H+ +R LP A L FL Sbjct: 310 NPFLVGLHS-CFQTTSRLFLVIEYVNGGDLMFHM-QRQRKLPEEHARFYAAEICIALNFL 367 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLDA+ + KL+D+G+ K+G GD T + GT Y APE Sbjct: 368 HE---RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT---STFCGTPNYIAPE 421 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEW 521 + D ++ GV++ EMM+GR D N + N ++ Sbjct: 422 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDY 465
>KPCZ_MOUSE (Q02956) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 75.9 bits (185), Expect = 9e-14 Identities = 59/164 (35%), Positives = 83/164 (50%), Gaps = 2/164 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 +P LV L C + RL LV E++ G L H+ +R LP A L FL Sbjct: 310 NPFLVGLHS-CFQTTSRLFLVIEYVNGGDLMFHM-QRQRKLPEEHARFYAAEICIALNFL 367 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLDA+ + KL+D+G+ K+G GD T + GT Y APE Sbjct: 368 HE---RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT---STFCGTPNYIAPE 421 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEW 521 + D ++ GV++ EMM+GR D N + N ++ Sbjct: 422 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDY 465
>KPCZ_HUMAN (Q05513) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 75.9 bits (185), Expect = 9e-14 Identities = 59/164 (35%), Positives = 83/164 (50%), Gaps = 2/164 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 +P LV L C + RL LV E++ G L H+ +R LP A L FL Sbjct: 310 NPFLVGLHS-CFQTTSRLFLVIEYVNGGDLMFHM-QRQRKLPEEHARFYAAEICIALNFL 367 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLDA+ + KL+D+G+ K+G GD T + GT Y APE Sbjct: 368 HE---RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT---STFCGTPNYIAPE 421 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEW 521 + D ++ GV++ EMM+GR D N + N ++ Sbjct: 422 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDY 465
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/157 (29%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G +HP+++ L G + ++V EFM GSL++ L ++ + + Sbjct: 684 LSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGML 743 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ + T + Sbjct: 744 RGIAAGMRYL---SDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDASNPTYTGAL 800 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE V TS SDV+S+G+V+ E+MS Sbjct: 801 GCKIPIRWTAPEAVQYRKFTSSSDVWSYGIVMWEVMS 837
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/158 (34%), Positives = 87/158 (55%), Gaps = 2/158 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRM-KIAL 185 E + LQH +LV+L+G + +V E + +G+L N L R L ++ + AL Sbjct: 274 ETAVMTKLQHRNLVRLLGVILHHGL-YIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFAL 332 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEG-DKTHVSTRVM 362 A+G+ +L + +++RD NIL+ + AK+SDFGLAK +G D + + + Sbjct: 333 HVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK-- 387 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRS 476 + APE + G +SKSDV+SFGV+L E+ S R+ Sbjct: 388 ----WTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRA 421
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/158 (29%), Positives = 84/158 (53%), Gaps = 2/158 (1%) Frame = +3 Query: 6 AEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 AE+ + +L H ++V+ +G+ + + E++ GS+ L R P + ++ Sbjct: 879 AEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCL-RNYGPFEEQLVRFVSR 937 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 GL++LH + +I+RD K N+L+D + K+SDFG++K + + G Sbjct: 938 QVLYGLSYLHSKG---IIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQG 994 Query: 366 TYGYAAPEYVMTGH--LTSKSDVYSFGVVLLEMMSGRR 473 + + APE + H ++K DV+S G V+LEM++GRR Sbjct: 995 SIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRR 1032
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/154 (35%), Positives = 83/154 (53%), Gaps = 1/154 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L ++ HP +V+L Y + + +L L+ +F+ G L L + ++ +A Sbjct: 112 ERDILADVHHPFVVRL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 169 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A GL LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 170 ELALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 T Y APE V + +D +S+GV++ EM++G Sbjct: 225 TVEYMAPEVVNRQGHSHGADWWSYGVLMFEMLTG 258 Score = 47.4 bits (111), Expect = 4e-05 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L E + LV E M G L + + R+ F + K + +L Sbjct: 466 QHPNIITLKDVYEECNSIYLVTELMRGGELLDRILRQKF-FSEREACSVLFTVCKTVEYL 524 Query: 213 HEEAERPVIYRDFKTSNILLDAE----YNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL E + ++ DFG +K + + T T + Sbjct: 525 HSQG---VVHRDLKPSNILYVDESGDPESIRICDFGFSKQ-LRAENGLLMTPCY-TANFV 579 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + D++S G++L M++G Sbjct: 580 APEVLKRQGYDEGCDIWSLGILLYTMLAG 608
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVLLWELMT 1278
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1131 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1190 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1191 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1247 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1248 MALESLQTQKFTTKSDVWSFGVLLWELMT 1276
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVLLWELMT 1278
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVLLWELMT 1278
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVLLWELMT 1278
>DSOR1_DROME (Q24324) Dual specificity mitogen-activated protein kinase kinase| dSOR1 (EC 2.7.12.2) (Downstream of RAF) (MAPKK) Length = 396 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/153 (30%), Positives = 82/153 (53%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ L PH+V G D + + E+M GSL+ + +R+ +P +I +I L Sbjct: 133 ELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDL-ILKRAGRIPESILGRITLA 191 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 KGL++L + +I+RD K SNIL+++ K+ DFG++ + ++ +GT Sbjct: 192 VLKGLSYLRDN--HAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDS----MANSFVGT 245 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 Y +PE + H + +SD++S G+ L+EM G Sbjct: 246 RSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIG 278
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1134 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1193 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1194 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1250 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1251 MALESLQTQKFTTKSDVWSFGVLLWELMT 1279
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1134 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1193 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1194 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1250 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1251 MALESLQTQKFTTKSDVWSFGVLLWELMT 1279
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVLLWELMT 1278
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1133 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1192 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1193 KYL---ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1249 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1250 MALESLQTQKFTTKSDVWSFGVLLWELMT 1278
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 75.5 bits (184), Expect = 1e-13 Identities = 49/171 (28%), Positives = 86/171 (50%), Gaps = 18/171 (10%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + EV + +L HP+++K +G +D + L+ E++ G+L++ L R P PW +++ A Sbjct: 374 LTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL-RNVDPFPWQQKVRFA 432 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA------KDGPEGDKTH 344 G A G+A+LH +I+RD + N L+ + ++DFGL+ + P +K Sbjct: 433 KGIASGMAYLHSMC---IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKAA 489 Query: 345 VSTR------------VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 R V+G + APE + DV+SFG+VL E++ Sbjct: 490 TKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII 540
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 75.5 bits (184), Expect = 1e-13 Identities = 57/185 (30%), Positives = 88/185 (47%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 +AE+ L NL H ++VK G+ + + ++ E+ GSL + R S L Sbjct: 68 MAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYV 127 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 GL +LH E VI+RD K +NILL A+ KL+DFG++ T + Sbjct: 128 TQTLLGLKYLHGEG---VIHRDIKAANILLSADNTVKLADFGVSTIVNSSALT-----LA 179 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWARPYLGE 542 GT + APE + ++ SD++S G ++EM++ KN P HNL + Y E Sbjct: 180 GTLNWMAPEILGNRGASTLSDIWSLGATVVEMLT------KNPP--YHNLTDANIYYAVE 231 Query: 543 RRRFY 557 +Y Sbjct: 232 NDTYY 236
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/174 (25%), Positives = 84/174 (48%), Gaps = 18/174 (10%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 EV + L+ P++++L+G C++DD ++ ++M G L L R Sbjct: 670 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTE 729 Query: 153 ------LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA 314 + + + + + A G+ +L A ++RD T N L+ + K++DFG++ Sbjct: 730 SDQGPTISYPMLLHVGAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 786 Query: 315 KDGPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRS 476 ++ GD V R + + A E ++ G T+ SDV++FGV L E++ RS Sbjct: 787 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRS 840
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/164 (28%), Positives = 84/164 (51%), Gaps = 10/164 (6%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP++++L G + +++ E+M GSL+ L + + I Sbjct: 42 LSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGIL 101 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEG-DKTHVSTRV 359 G A G+ +L ++ ++RD NIL+++ K+SDFG+++ E D + + + Sbjct: 102 RGIASGMKYL---SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREI 158 Query: 360 MGTYG---------YAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 GTY + APE + TS SDV+S+G+V+ E+MS Sbjct: 159 TGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMS 202
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 75.5 bits (184), Expect = 1e-13 Identities = 55/182 (30%), Positives = 83/182 (45%), Gaps = 30/182 (16%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 E + L NLQH H+VK G C + D ++V+E+M G L N R P Sbjct: 588 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDL-NKFLRAHGPDAMILVDGQPRQ 646 Query: 153 ----LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 L + + IA A G+ +L A + ++RD T N L+ A K+ DFG+++D Sbjct: 647 AKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRD 703 Query: 321 ----------GPEGDK----THVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEM 458 P G+ V M + PE +M T++SDV+SFGV+L E+ Sbjct: 704 VYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 763 Query: 459 MS 464 + Sbjct: 764 FT 765
>KPCI_PONPY (Q5R4K9) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| Length = 587 Score = 75.1 bits (183), Expect = 2e-13 Identities = 55/151 (36%), Positives = 79/151 (52%), Gaps = 2/151 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLL-VYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 HP LV L C + + RL V E++ G L H+ +R LP + + L +L Sbjct: 303 HPFLVGLHS-CFQTESRLFFVIEYVNGGDLMFHM-QRQRKLPEEHARFYSAEISLALNYL 360 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLD+E + KL+D+G+ K+G GD T + GT Y APE Sbjct: 361 HE---RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFCGTPNYIAPE 414 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 + D ++ GV++ EMM+GR D Sbjct: 415 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 445
>KPCI_HUMAN (P41743) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota) Length = 587 Score = 75.1 bits (183), Expect = 2e-13 Identities = 55/151 (36%), Positives = 79/151 (52%), Gaps = 2/151 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLL-VYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 HP LV L C + + RL V E++ G L H+ +R LP + + L +L Sbjct: 303 HPFLVGLHS-CFQTESRLFFVIEYVNGGDLMFHM-QRQRKLPEEHARFYSAEISLALNYL 360 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLD+E + KL+D+G+ K+G GD T + GT Y APE Sbjct: 361 HE---RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFCGTPNYIAPE 414 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 + D ++ GV++ EMM+GR D Sbjct: 415 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 445
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 75.1 bits (183), Expect = 2e-13 Identities = 44/148 (29%), Positives = 82/148 (55%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 +G+L H H+V+L+G C +L V +++P GSL +H+ + L + + + AKG Sbjct: 761 VGSLDHAHIVRLLGLCPGSSLQL-VTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQIAKG 819 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 + +L E + +++RD N++L + +++DFG+A P DK + + + Sbjct: 820 MYYLEEHS---MVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWM 876 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + G T +SDV+S+GV + E+M+ Sbjct: 877 ALESIHFGKYTHQSDVWSYGVTVWELMT 904
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 75.1 bits (183), Expect = 2e-13 Identities = 44/148 (29%), Positives = 82/148 (55%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 +G+L H H+V+L+G C +L V +++P GSL +H+ + L + + + AKG Sbjct: 761 VGSLDHAHIVRLLGLCPGSSLQL-VTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKG 819 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 + +L E + +++RD N++L + +++DFG+A P DK + + + Sbjct: 820 MYYLEEHS---MVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWM 876 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + G T +SDV+S+GV + E+M+ Sbjct: 877 ALESIHFGKYTHQSDVWSYGVTVWELMT 904
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 75.1 bits (183), Expect = 2e-13 Identities = 45/157 (28%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP+++ L G + +++ EFM GSL++ L + + + Sbjct: 686 LSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGML 745 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ + T + Sbjct: 746 RGIAAGMKYL---ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSAL 802 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 803 GGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 839
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 75.1 bits (183), Expect = 2e-13 Identities = 52/192 (27%), Positives = 93/192 (48%), Gaps = 16/192 (8%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L + + +P I K++ Sbjct: 114 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KEAKRIPEEILGKVS 172 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + +GLA+L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 173 IAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 226 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR----------------RSMDKNRP 494 GT Y +PE + H + +SD++S G+ L+E+ GR R + Sbjct: 227 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPVVDGAE 286 Query: 495 NGEHNLVEWARP 530 H++ WARP Sbjct: 287 GESHSVSPWARP 298
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 75.1 bits (183), Expect = 2e-13 Identities = 53/164 (32%), Positives = 83/164 (50%), Gaps = 1/164 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + L HP++++L + LV E+ +G L N L R PLP ++ Sbjct: 81 EIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERG-PLPEHEAIRFFRQ 139 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 G+++ H +++RD K N+LLD +YN K++DFG+A EG S G+ Sbjct: 140 IIIGVSYCHALG---IVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETS---CGS 193 Query: 369 YGYAAPEYVM-TGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPN 497 YAAPE V + SDV+S GV+L +++GR D+ N Sbjct: 194 PHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGN 237
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 75.1 bits (183), Expect = 2e-13 Identities = 47/149 (31%), Positives = 76/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1134 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1193 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L A + ++RD N +LD + K++DFGLA+D E H T + Sbjct: 1194 KYL---ASKKFVHRDLAARNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1250 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1251 MALESLQTQKFTTKSDVWSFGVLLWELMT 1279
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 75.1 bits (183), Expect = 2e-13 Identities = 54/158 (34%), Positives = 87/158 (55%), Gaps = 2/158 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLP-WAIRMKIAL 185 E + +QH +LV+L+G + +V E + +G+L N L R L A ++ +L Sbjct: 276 ETAVMTKMQHENLVRLLGVILHQGL-YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL 334 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEG-DKTHVSTRVM 362 A+G+ +L + +++RD NIL+ + AK+SDFGLAK +G D + + + Sbjct: 335 HVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK-- 389 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRS 476 + APE + G TSKSDV+SFGV+L E+ S R+ Sbjct: 390 ----WTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRA 423
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 75.1 bits (183), Expect = 2e-13 Identities = 41/111 (36%), Positives = 66/111 (59%), Gaps = 1/111 (0%) Frame = +3 Query: 168 RMKIA-LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTH 344 R+K A L + LA++H +++RD K SNI++D + +L DFGLAK + Sbjct: 220 RLKDAMLQICEALAYIHGHG---LVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAIT 276 Query: 345 VSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPN 497 + +++GTY Y APE ++ L ++D+YS GV+L E++SGR D P+ Sbjct: 277 EAGKLVGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFDAKTPH 327
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 75.1 bits (183), Expect = 2e-13 Identities = 48/157 (30%), Positives = 79/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++V L G ++V EFM G+L+ L + + + Sbjct: 680 LCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGML 739 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 740 RGIAAGMRYL---ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGG 796 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E+MS Sbjct: 797 KI--PVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 831
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 75.1 bits (183), Expect = 2e-13 Identities = 48/157 (30%), Positives = 79/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++V L G ++V EFM G+L+ L + + + Sbjct: 680 LCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGML 739 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 740 RGIAAGMRYL---ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGG 796 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E+MS Sbjct: 797 KI--PVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 831
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 75.1 bits (183), Expect = 2e-13 Identities = 48/157 (30%), Positives = 79/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++V L G ++V EFM G+L+ L + + + Sbjct: 680 LCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGML 739 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 740 RGIAAGMRYL---ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGG 796 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E+MS Sbjct: 797 KI--PVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 831
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 75.1 bits (183), Expect = 2e-13 Identities = 48/171 (28%), Positives = 86/171 (50%), Gaps = 18/171 (10%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + EV + +L HP+++K +G +D + L+ E++ G+L++ L R + P PW ++ A Sbjct: 374 LTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL-RNADPFPWQQKVSFA 432 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA------KDGPEGDKTH 344 G A G+A+LH +I+RD + N L+ + ++DFGL+ + P +K Sbjct: 433 KGIASGMAYLHSMC---IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPTLEKPS 489 Query: 345 VSTR------------VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 R V+G + APE + D++SFG+VL E++ Sbjct: 490 AKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGQSYDETVDIFSFGIVLCEII 540
>KPCI_BRARE (Q90XF2) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) Length = 588 Score = 75.1 bits (183), Expect = 2e-13 Identities = 55/151 (36%), Positives = 79/151 (52%), Gaps = 2/151 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLL-VYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 HP LV L C + + RL V E++ G L H+ +R LP + + L +L Sbjct: 304 HPFLVGLHS-CFQTESRLFFVIEYVNGGDLMFHM-QRQRKLPEEHARFYSAEISLALNYL 361 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLD+E + KL+D+G+ K+G GD T + GT Y APE Sbjct: 362 HE---RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFCGTPNYIAPE 415 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 + D ++ GV++ EMM+GR D Sbjct: 416 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 446
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/157 (29%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++++L G + ++V E+M GSL++ L + + + Sbjct: 669 LGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 728 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 729 RGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 785 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + +PE TS SDV+S+G+VL E+MS Sbjct: 786 KI--PVRWTSPEATAYRKFTSASDVWSYGIVLWEVMS 820
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 75.1 bits (183), Expect = 2e-13 Identities = 53/157 (33%), Positives = 86/157 (54%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRM 173 +AE + + +LQH LVKL + + +V EFM +GSL + L PLP I Sbjct: 300 LAEANLMKSLQHDKLVKLHAV-VSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDF 358 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 + ++G+AF+ + R I+RD + +NIL+ A K++DFGLA+ + + T Sbjct: 359 SAQI--SEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYT-ARE 412 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + G T KSDV+SFG++L+E+++ Sbjct: 413 GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 449
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 75.1 bits (183), Expect = 2e-13 Identities = 53/168 (31%), Positives = 78/168 (46%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF------------- 149 E + L LQH H+V+ G C E L+V+E+M G L F RS Sbjct: 560 EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNR--FLRSHGPDAKLLAGGEDV 617 Query: 150 ---PLPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 PL + +A A G+ +L A ++RD T N L+ K+ DFG+++D Sbjct: 618 APGPLGLGQLLAVASQVAAGMVYL---AGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 674 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V R M + PE ++ T++SDV+SFGVVL E+ + Sbjct: 675 IYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFT 722
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 75.1 bits (183), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 111 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGKIPEKILGKVS 169 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 170 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 223 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 224 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGR 259
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 75.1 bits (183), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 112 IRELQVLHECNSPYIVGFYGVFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVS 170 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 171 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 224 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260
>KPCI_MOUSE (Q62074) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) Length = 586 Score = 75.1 bits (183), Expect = 2e-13 Identities = 55/151 (36%), Positives = 79/151 (52%), Gaps = 2/151 (1%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLL-VYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 HP LV L C + + RL V E++ G L H+ +R LP + + L +L Sbjct: 302 HPFLVGLHS-CFQTESRLFFVIEYVNGGDLMFHM-QRQRKLPEEHARFYSAEISLALNYL 359 Query: 213 HEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPE 389 HE R +IYRD K N+LLD+E + KL+D+G+ K+G GD T + GT Y APE Sbjct: 360 HE---RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFCGTPNYIAPE 413 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 + D ++ GV++ EMM+GR D Sbjct: 414 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 444
>PKN1_HUMAN (Q16512) Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein| kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha) Length = 942 Score = 74.7 bits (182), Expect = 2e-13 Identities = 53/145 (36%), Positives = 70/145 (48%), Gaps = 1/145 (0%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFLH 215 HP LV L G + V E+ G L H+ F P AI + GL FLH Sbjct: 675 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACV--VLGLQFLH 732 Query: 216 EEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPEY 392 E ++YRD K N+LLD E K++DFGL K+G GD+T + GT + APE Sbjct: 733 EHK---IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRT---STFCGTPEFLAPEV 786 Query: 393 VMTGHLTSKSDVYSFGVVLLEMMSG 467 + T D + GV+L EM+ G Sbjct: 787 LTDTSYTRAVDWWGLGVLLYEMLVG 811
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 74.7 bits (182), Expect = 2e-13 Identities = 52/168 (30%), Positives = 78/168 (46%), Gaps = 16/168 (9%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF------------- 149 E + L LQH H+V+ G C E L+V+E+M G L F RS Sbjct: 563 EAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNR--FLRSHGPDAKLLAGGEDV 620 Query: 150 ---PLPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD 320 PL + +A A G+ +L A ++RD T N L+ K+ DFG+++D Sbjct: 621 APGPLGLGQLLAVASQVAAGMVYL---ASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 677 Query: 321 GPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D V R M + PE ++ +++SDV+SFGVVL E+ + Sbjct: 678 IYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFT 725
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 105 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVS 163 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 164 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 217 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 218 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGR 253
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/157 (28%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G +HP++++L G +++ EFM G+L++ L + + Sbjct: 662 LSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGML 721 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L AE ++RD NIL+++ K+SDFGL++ E T + Sbjct: 722 RGIASGMRYL---AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSL 778 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + + APE + TS SD +S+G+V+ E+MS Sbjct: 779 GGKISIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMS 815
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/157 (28%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP+++ L G + +++ EFM GSL++ L + + + Sbjct: 668 LSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGML 727 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ + T + Sbjct: 728 RGIAAGMKYL---ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSAL 784 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 785 GGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 821
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 74.7 bits (182), Expect = 2e-13 Identities = 43/169 (25%), Positives = 82/169 (48%), Gaps = 18/169 (10%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 EV + L+ P++++L+G C++DD ++ ++M G L L Sbjct: 668 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQ 727 Query: 153 ------LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA 314 + + + + +A A G+ +L A ++RD T N L+ + K++DFG++ Sbjct: 728 AAQGPTISYPMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 784 Query: 315 KDGPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 ++ GD V R + + A E ++ G T+ SDV++FGV L E++ Sbjct: 785 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 833
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/157 (28%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP+++ L G + +++ EFM GSL++ L + + + Sbjct: 676 LSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGML 735 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ + T + Sbjct: 736 RGIAAGMKYL---ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSAL 792 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 793 GGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 829
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 74.7 bits (182), Expect = 2e-13 Identities = 53/157 (33%), Positives = 85/157 (54%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSF---PLPWAIRM 173 +AE + + LQH LVKL + + +V EFM +GSL + L PLP I Sbjct: 279 LAEANLMKTLQHDKLVKLHAV-VSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDF 337 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 + ++G+AF+ + R I+RD + +NIL+ A K++DFGLA+ + + T Sbjct: 338 SAQI--SEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYT-ARE 391 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + G T KSDV+SFG++L+E+++ Sbjct: 392 GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 428
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/157 (28%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP++++L G + +++ EFM G+L++ L + + + Sbjct: 666 LSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGML 725 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L AE ++RD NIL+++ K+SDFGL++ + T + Sbjct: 726 RGIAAGMKYL---AEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSL 782 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 783 GGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS 819
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/157 (28%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP++++L G + +++ EFM G+L++ L + + + Sbjct: 666 LSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGML 725 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L AE ++RD NIL+++ K+SDFGL++ + T + Sbjct: 726 RGIAAGMKYL---AEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSL 782 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 783 GGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS 819
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 74.7 bits (182), Expect = 2e-13 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 3/158 (1%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRR---SFPLPWAIRMKI 179 E + L+H HLV+L C + + +V E+M GSL ++L + + LP I M Sbjct: 283 EAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDM-- 340 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 A A G+AFL + I+RD NIL+ Y K++DFGLA+ E D+ Sbjct: 341 AAQVASGMAFLEAQG---YIHRDLAARNILVGENYICKVADFGLARL-IEDDEYTAHEGA 396 Query: 360 MGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRR 473 + APE + T KSDV+SFG+++ E+++ R Sbjct: 397 KFPIKWTAPEAALYNRFTIKSDVWSFGILMAEIVTKGR 434
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 111 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVS 169 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 170 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 223 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 224 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 111 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVS 169 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 170 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 223 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 224 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 111 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVS 169 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 170 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 223 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 224 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L +++ +P I K++ Sbjct: 111 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVS 169 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + KGL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 170 IAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 223 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+EM GR Sbjct: 224 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 259
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 74.7 bits (182), Expect = 2e-13 Identities = 50/169 (29%), Positives = 80/169 (47%), Gaps = 17/169 (10%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIR------ 170 E + L ++H ++V G C E DQ ++++EFM G L +L R P ++ Sbjct: 555 EAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNKYL-RMHGPDAAFLKDRDSMD 613 Query: 171 -----------MKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK 317 MKI L A + +L A + ++RD T N L+ + KL DFG+++ Sbjct: 614 SDEGQLTREQLMKIVLQIASAMEYL---ALQHFVHRDLATRNCLVGCDLVVKLGDFGMSR 670 Query: 318 DGPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 D D V M + PE ++ T++SDV+SFGV L E+ + Sbjct: 671 DVYTTDYYRVEGTAMLPVRWMPPESIIYRTFTTESDVWSFGVTLWEVFT 719
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/157 (28%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++++L G + ++V E+M GSL++ L + + + Sbjct: 668 LGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 727 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 728 RGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 784 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + +PE + TS SD +S+G+VL E+MS Sbjct: 785 KI--PIRWTSPEAIAYRKFTSASDAWSYGIVLWEVMS 819
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/156 (30%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L + + +P I K++ Sbjct: 116 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KEAKRIPEEILGKVS 174 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + +GLA+L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 175 IAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 228 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y APE + H + +SD++S G+ L+E+ GR Sbjct: 229 GTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGR 264
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 74.7 bits (182), Expect = 2e-13 Identities = 46/157 (29%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP+++ L G + ++V E+M GSL+ L + + + Sbjct: 698 LGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGML 757 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 758 RGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 814 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E+MS Sbjct: 815 KI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMS 849
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 74.7 bits (182), Expect = 2e-13 Identities = 43/169 (25%), Positives = 82/169 (48%), Gaps = 18/169 (10%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFP------------ 152 EV + L+ P++++L+G C++DD ++ ++M G L L Sbjct: 672 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQ 731 Query: 153 ------LPWAIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA 314 + + + + +A A G+ +L A ++RD T N L+ + K++DFG++ Sbjct: 732 AAQGPTISYPMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 788 Query: 315 KDGPEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 ++ GD V R + + A E ++ G T+ SDV++FGV L E++ Sbjct: 789 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 837
>PKN1_MOUSE (P70268) Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein| kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) Length = 946 Score = 74.3 bits (181), Expect = 3e-13 Identities = 52/145 (35%), Positives = 70/145 (48%), Gaps = 1/145 (0%) Frame = +3 Query: 36 HPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFLH 215 HP LV L G + V E+ G L H+ F P A+ + GL FLH Sbjct: 679 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVFYSACV--VLGLQFLH 736 Query: 216 EEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGYAAPEY 392 E ++YRD K N+LLD E K++DFGL K+G GD+T + GT + APE Sbjct: 737 EHK---IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRT---STFCGTPEFLAPEV 790 Query: 393 VMTGHLTSKSDVYSFGVVLLEMMSG 467 + T D + GV+L EM+ G Sbjct: 791 LTDTSYTRAVDWWGLGVLLYEMLVG 815
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 74.3 bits (181), Expect = 3e-13 Identities = 52/162 (32%), Positives = 83/162 (51%), Gaps = 5/162 (3%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKI 179 + E + ++ H+V + G C Q L +V EFM GSLE L S L W +R +I Sbjct: 69 IEEAAKMKKIKFQHIVSIYGVC---KQPLGIVMEFMANGSLEKVLSTHS--LCWKLRFRI 123 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR- 356 + + FLH + P+++ D K NILLD+ + K+SDFGL+K + + R Sbjct: 124 IHETSLAMNFLHS-IKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERS 182 Query: 357 -VMGTYGYAAPEYVMTGHLT--SKSDVYSFGVVLLEMMSGRR 473 + G Y PE + + K DVYSF +V+ E+++ ++ Sbjct: 183 ALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKK 224
>YPC2_CAEEL (Q11179) Putative serine/threonine-protein kinase C05D10.2 in| chromosome III (EC 2.7.11.24) Length = 470 Score = 74.3 bits (181), Expect = 3e-13 Identities = 58/164 (35%), Positives = 84/164 (51%), Gaps = 10/164 (6%) Frame = +3 Query: 9 EVDFLGNL-QHPHLVKLVGYCIEDDQR--LLVYEFMPRGSLENHLFRRSFPLPWAIRMKI 179 EV FL +HP+++KL D+ R L +EFM L N + + S L + I Sbjct: 60 EVMFLQEFGKHPNVIKLYNIFRADNDRDIYLAFEFM-EADLHNVIKKGSI-LKDVHKQYI 117 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK------DGPEGDKT 341 + + FLH V++RD K SN+LLDA+ KL+DFGLA+ D PEG K Sbjct: 118 MCQLFRAIRFLHSGN---VLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDYPEGQKM 174 Query: 342 HVSTRVMGTYGYAAPEYVMTGHLTSKS-DVYSFGVVLLEMMSGR 470 T + T Y +PE ++ +K D++S G +L EM+ GR Sbjct: 175 PDLTEYVATRWYRSPEILLAAKRYTKGVDMWSLGCILAEMLIGR 218
>ANPRA_RAT (P18910) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/155 (29%), Positives = 79/155 (50%), Gaps = 5/155 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q+ HL + VG C + ++ E+ PRGSL++ L S L W R + Sbjct: 579 ELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTND 638 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK-DGPEGDKTHVSTRVMG 365 KG+ FLH A + + K+SN ++D + K++D+GL PE ++ H + Sbjct: 639 IVKGMLFLHNGA--ICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHT---LFA 693 Query: 366 TYGYAAPEYVMTGHLTSK----SDVYSFGVVLLEM 458 + APE + ++ DVYSFG++L E+ Sbjct: 694 KKLWTAPELLRMASPPARGSQAGDVYSFGIILQEI 728
>ANPRA_MOUSE (P18293) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/155 (29%), Positives = 79/155 (50%), Gaps = 5/155 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ + ++Q+ HL + VG C + ++ E+ PRGSL++ L S L W R + Sbjct: 579 ELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTND 638 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK-DGPEGDKTHVSTRVMG 365 KG+ FLH A + + K+SN ++D + K++D+GL PE ++ H + Sbjct: 639 IVKGMLFLHNGAIGS--HGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHT---LFA 693 Query: 366 TYGYAAPEYVMTGHLTSK----SDVYSFGVVLLEM 458 + APE + ++ DVYSFG++L E+ Sbjct: 694 KKLWTAPELLRMASPPARGSQAGDVYSFGIILQEI 728
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 73.9 bits (180), Expect = 4e-13 Identities = 45/157 (28%), Positives = 79/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G +HP++++L G +++ EFM G+L++ L + + Sbjct: 662 LSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGML 721 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L AE ++RD NIL+++ K+SDFGL++ E T + Sbjct: 722 RGIASGMRYL---AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSL 778 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SD +S+G+V+ E+MS Sbjct: 779 GGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMS 815
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 73.9 bits (180), Expect = 4e-13 Identities = 46/149 (30%), Positives = 76/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDD-QRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGL 203 + HP+++ L+G C+ + L+V +M G L N + + + L AKG+ Sbjct: 1134 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 1193 Query: 204 AFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD--GPEGDKTHVSTRVMGTYGY 377 +L + ++RD N +LD ++ K++DFGLA+D E H T + Sbjct: 1194 KYL---VSKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKW 1250 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + T T+KSDV+SFGV+L E+M+ Sbjct: 1251 MALESLQTQKFTTKSDVWSFGVLLWELMT 1279
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 73.9 bits (180), Expect = 4e-13 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 15/173 (8%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HP+++K +G +D + + E++ G+L + PW+ R+ A Sbjct: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKD 443 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---------------DG 323 A G+A+LH +I+RD + N L+ N ++DFGLA+ Sbjct: 444 IASGMAYLH---SMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKK 500 Query: 324 PEGDKTHVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 P+ K + V+G + APE + K DV+SFG+VL E++ GR + D Sbjct: 501 PDRKKRYT---VVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 73.9 bits (180), Expect = 4e-13 Identities = 48/171 (28%), Positives = 86/171 (50%), Gaps = 18/171 (10%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + EV + +L HP+++K +G +D + L+ E++ G+L++ L R P PW +++ A Sbjct: 374 LTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL-RSVDPFPWQQKVRFA 432 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLA------KDGPEGDKTH 344 G + G+A+LH +I+RD + N L+ + ++DFGL+ + P +K Sbjct: 433 KGISSGMAYLHSMC---IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKAT 489 Query: 345 VSTR------------VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 R V+G + APE + DV+SFG+VL E++ Sbjct: 490 TKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII 540
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 73.9 bits (180), Expect = 4e-13 Identities = 47/157 (29%), Positives = 79/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++V L G ++V E+M G+L+ L + + + Sbjct: 675 LCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGML 734 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L A+ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 735 RGIAAGMRYL---ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGG 791 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E+MS Sbjct: 792 KI--PVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 826
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 73.9 bits (180), Expect = 4e-13 Identities = 44/148 (29%), Positives = 81/148 (54%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 +G+L H H+V+L+G C +L V +++P GSL +H+ + L + + + AKG Sbjct: 763 IGSLDHAHIVRLLGLCPGSSLQL-VTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKG 821 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 + +L E +++R+ N+LL + +++DFG+A P DK + + + Sbjct: 822 MYYLEEHG---MVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWM 878 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + G T +SDV+S+GV + E+M+ Sbjct: 879 ALESIHFGKYTHQSDVWSYGVTVWELMT 906
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 73.9 bits (180), Expect = 4e-13 Identities = 44/148 (29%), Positives = 81/148 (54%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 +G+L H H+V+L+G C +L V +++P GSL +H+ + L + + + AKG Sbjct: 763 IGSLDHAHIVRLLGLCPGSSLQL-VTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKG 821 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 + +L E +++R+ N+LL + +++DFG+A P DK + + + Sbjct: 822 MYYLEEHG---MVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWM 878 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMS 464 A E + G T +SDV+S+GV + E+M+ Sbjct: 879 ALESIHFGKYTHQSDVWSYGVTVWELMT 906
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 73.6 bits (179), Expect = 5e-13 Identities = 46/152 (30%), Positives = 77/152 (50%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E +G HPH+++L G + +++ EFM G+L+ L R L + + LG Sbjct: 674 EATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAMLLG 733 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+ L + ++RD NIL++ K+SDFGL + + D T+ + Sbjct: 734 IASGMNCL---SGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIP 790 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + T+ SDV+SFG+V+ E++S Sbjct: 791 IRWTAPEAIAHRIFTTASDVWSFGIVMWEVLS 822
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 73.6 bits (179), Expect = 5e-13 Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 5/159 (3%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP++++L G +++ EFM G+L++ L + I Sbjct: 656 LGEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDSFLRMNDGQFTVIQLVGIL 715 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK--DGPEGDKTHVSTR 356 G A G+ +L +E ++RD NIL+++ K+SDFGL++ + D T+ S Sbjct: 716 RGIASGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLENSRSDPTYTSA- 771 Query: 357 VMG---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 +G + APE + TS SDV+S+G+V+ E+MS Sbjct: 772 -LGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMS 809
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 73.6 bits (179), Expect = 5e-13 Identities = 56/157 (35%), Positives = 87/157 (55%), Gaps = 1/157 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRM-KIAL 185 E + LQH +LV+L+G + +V E + +G+L N L R L ++ + AL Sbjct: 235 ETAVMTKLQHRNLVRLLGVILHHGL-YIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFAL 293 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A+G+ +L + +++RD NIL+ + AK+SDFGLAK E K S+R+ Sbjct: 294 HVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDFGLAK--AELRKGLDSSRL-- 346 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRS 476 + APE + G +SKSDV+SFGV+L E+ S R+ Sbjct: 347 PVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRA 383
>PKN2_RAT (O08874) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) (Protease-activated kinase 2) (PAK-2) (Fragment) Length = 842 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 1/150 (0%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKG 200 + +++HP LV L + V E+ G L H+ F P A+ A G Sbjct: 576 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFY--AACVVLG 633 Query: 201 LAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDG-PEGDKTHVSTRVMGTYGY 377 L +LHE ++YRD K N+LLD E + K++DFGL K+G GD+T + GT + Sbjct: 634 LQYLHEHK---IVYRDLKLDNLLLDTEASVKIADFGLCKEGMGYGDRT---STFCGTPEF 687 Query: 378 AAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + T D + GV++ EM+ G Sbjct: 688 LAPEVLTETSYTRAVDWWGLGVLIYEMLVG 717
>EPHAA_HUMAN (Q5JZY3) Ephrin type-A receptor 10 precursor (EC 2.7.10.1)| Length = 1008 Score = 73.6 bits (179), Expect = 5e-13 Identities = 48/156 (30%), Positives = 78/156 (50%), Gaps = 2/156 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 +AE LG H H+V+L G ++V E+M G+L+ L R L M + Sbjct: 692 LAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLL 751 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A + +L +E ++R ++L+ ++ K+S FG GP V T + Sbjct: 752 PGLASAMKYL---SEMGYVHRGLAARHVLVSSDLVCKISGFGR---GPRDRSEAVYTTMS 805 Query: 363 GTYG--YAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G +AAPE + GH +S SDV+SFG+++ E+M+ Sbjct: 806 GRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVMA 841
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 73.6 bits (179), Expect = 5e-13 Identities = 53/157 (33%), Positives = 85/157 (54%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR---RSFPLPWAIRM 173 +AE + + LQH LVKL + + ++ EFM +GSL + L PLP I Sbjct: 302 LAEANVMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 360 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 + A+G+AF+ + R I+RD + +NIL+ A K++DFGLA+ + + T Sbjct: 361 SAQI--AEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYT-ARE 414 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + G T KSDV+SFG++L+E+++ Sbjct: 415 GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 451
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/170 (29%), Positives = 83/170 (48%), Gaps = 12/170 (7%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HP+++K +G +D + + E++ G+L + PW+ R+ A Sbjct: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 443 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK-----DGPEGDKTHVST 353 A G+A+LH +I+RD + N L+ N ++DFGLA+ G D + Sbjct: 444 IASGMAYLH---SMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKK 500 Query: 354 -------RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 V+G + APE + K DV+SFG+VL E++ GR + D Sbjct: 501 PDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNAD 549
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 73.6 bits (179), Expect = 5e-13 Identities = 44/157 (28%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP++++L G + +++ EFM G+L++ L + + + Sbjct: 666 LSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGML 725 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L +E ++RD NIL+++ K+SDFGL++ + T + Sbjct: 726 RGIAAGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSL 782 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 783 GGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS 819
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/160 (31%), Positives = 83/160 (51%), Gaps = 4/160 (2%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKI 179 ++E+ ++ HP++V+ + C EDD + ++ E P GSL L RR +R Sbjct: 127 LSEIQIHKSMSHPNIVQFID-CFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRF-F 184 Query: 180 ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRV 359 + ++H R VI+RD K NI D+ YN K+ DFGLA +++ + Sbjct: 185 TTQICGAIKYMHS---RRVIHRDLKLGNIFFDSNYNLKIGDFGLA--AVLANESERKYTI 239 Query: 360 MGTYGYAAPEYVM---TGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y APE +M +GH + + D++S GV+L ++ G+ Sbjct: 240 CGTPNYIAPEVLMGKHSGH-SFEVDIWSLGVMLYALLIGK 278
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 73.6 bits (179), Expect = 5e-13 Identities = 44/157 (28%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP++++L G + +++ EFM G+L++ L + + + Sbjct: 584 LSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGML 643 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L +E ++RD NIL+++ K+SDFGL++ + T + Sbjct: 644 RGIAAGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSL 700 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 701 GGKIPVRWTAPEAIRYRKFTSASDVWSYGIVMWEVMS 737
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 73.2 bits (178), Expect = 6e-13 Identities = 46/156 (29%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L + + +P I K++ Sbjct: 116 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KEAKRIPEDILGKVS 174 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + +GLA+L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 175 IAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 228 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+E+ GR Sbjct: 229 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGR 264
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 73.2 bits (178), Expect = 6e-13 Identities = 46/157 (29%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP++++L G ++V E+M GSL+ L + + + Sbjct: 673 LSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFTVIQLLGML 732 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L +E ++RD NIL++ K+SDFGL++ D PE T Sbjct: 733 RGIAAGMQYL---SEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLEDDPEAAYTTRGG 789 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E++S Sbjct: 790 KI--PIRWTAPEAITYRKFTSASDVWSYGIVMWEVIS 824
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 73.2 bits (178), Expect = 6e-13 Identities = 48/159 (30%), Positives = 79/159 (49%), Gaps = 1/159 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+D L L HPH+ +L LV E + G L +++ R+ LP + Sbjct: 72 EIDNLQKLTHPHITRLFRVISTPSDIFLVMELVSGGELFSYITRKG-ALPIRESRRYFQQ 130 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 G+++ H +++RD K N+LLDA N K++DFGL+ +GD + + G+ Sbjct: 131 IISGVSYCHNHM---IVHRDLKPENLLLDANKNIKIADFGLSNYMTDGD---LLSTACGS 184 Query: 369 YGYAAPEYVMTG-HLTSKSDVYSFGVVLLEMMSGRRSMD 482 YAAPE + ++ + D++S GV+L M+ G D Sbjct: 185 PNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFD 223
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 73.2 bits (178), Expect = 6e-13 Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 6/196 (3%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKI- 179 +AE + + LQHP LV+L + + ++ E+M GSL + L P I++ + Sbjct: 285 LAEANLMKQLQHPRLVRLYAV-VTQEPIYIITEYMENGSLVDFL-----KTPSGIKLNVN 338 Query: 180 -----ALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTH 344 A A+G+AF+ E+ I+RD + +NIL+ + K++DFGLA+ + + T Sbjct: 339 KLLDMAAQIAEGMAFIEEQN---YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYT- 394 Query: 345 VSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGEHNLVEWA 524 + APE + G T KSDV+SFG++L E+++ R N E Sbjct: 395 AREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPE------- 447 Query: 525 RPYLGERRRFYRLVDP 572 + R YR+V P Sbjct: 448 --VIQNLERGYRMVRP 461
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 73.2 bits (178), Expect = 6e-13 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP+++ L G + +++ EFM GSL++ L + + + Sbjct: 669 LSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGML 728 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 G A G+ +L A+ ++RD N L+++ K+SDFGL++ + T + Sbjct: 729 RGIAAGMKYL---ADMNYVHRDLAARNTLVNSNLVCKVSDFGLSRFLEDDTSDPTYTSAL 785 Query: 363 G---TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 G + APE + TS SDV+S+G+V+ E+MS Sbjct: 786 GGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS 822
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 73.2 bits (178), Expect = 6e-13 Identities = 49/165 (29%), Positives = 81/165 (49%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E + L H LV+L G CI+ +V EFM G L ++L R L A+ + + Sbjct: 312 IEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMC 371 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 +G+A+L I+RD N L+ + K+SDFG+A+ + D+ S+ Sbjct: 372 QDICEGMAYLERSC---YIHRDLAARNCLVSSACVVKISDFGMARYVLD-DEYISSSGAK 427 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPN 497 + PE +SKSDV+SFGV++ E+ + + +N+ N Sbjct: 428 FPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSN 472
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 73.2 bits (178), Expect = 6e-13 Identities = 52/167 (31%), Positives = 85/167 (50%), Gaps = 5/167 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E L ++HP +V++V + D LV EF+ SL + L P+P + + Sbjct: 61 EARLLSAVEHPAVVRIVDFGESGDHACLVMEFVEGESLYDVL--TPGPMPPGRALPLLQQ 118 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYN---AKLSDFGLAKDGPEGDKTHVSTR- 356 A+GLA +H++ +I+RD K N+ + A+L DFG+A+ + VS Sbjct: 119 LAEGLAAIHDKG---IIHRDLKPENVFISKSARGEQARLLDFGIARLVEPDAASSVSQIG 175 Query: 357 -VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRP 494 V+GT Y +PE + + ++SD+YSFGV+ ++SGR D P Sbjct: 176 VVLGTPEYLSPEQAVGAKVDTRSDLYSFGVLTYRVLSGRLPFDGPLP 222
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 73.2 bits (178), Expect = 6e-13 Identities = 47/154 (30%), Positives = 83/154 (53%), Gaps = 8/154 (5%) Frame = +3 Query: 30 LQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAF 209 L+H ++ L G C+ + + LV E+ GSL L + +P + + A+ A+G+ + Sbjct: 196 LKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAGK---IPPDVLVNWAIQIARGMNY 251 Query: 210 LHEEAERPVIYRDFKTSNILLD--------AEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 LH EA +I+RD K+SN+L+ + K++DFGLA++ + + G Sbjct: 252 LHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAA----G 307 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 TY + PE + + SDV+S+GV+L E+++G Sbjct: 308 TYAWMPPEVISVSTYSKFSDVWSYGVLLWELITG 341
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 73.2 bits (178), Expect = 6e-13 Identities = 53/157 (33%), Positives = 85/157 (54%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR---RSFPLPWAIRM 173 +AE + + LQH LVKL + + ++ EFM +GSL + L PLP I Sbjct: 280 LAEANLMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 338 Query: 174 KIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVST 353 + A+G+AF+ + R I+RD + +NIL+ A K++DFGLA+ + + T Sbjct: 339 SAQI--AEGMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYT-ARE 392 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + G T KSDV+SFG++L+E+++ Sbjct: 393 GAKFPIKWTAPEAINFGSSTIKSDVWSFGILLMEIVT 429
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 73.2 bits (178), Expect = 6e-13 Identities = 45/157 (28%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 ++E +G HP+++ L G + ++V E+M GSL+ L + + + Sbjct: 724 LSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGML 783 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 784 RGIAAGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 840 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E++S Sbjct: 841 KI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS 875
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 73.2 bits (178), Expect = 6e-13 Identities = 53/147 (36%), Positives = 74/147 (50%), Gaps = 1/147 (0%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAAKGLAF 209 +HP+L +L D+ V E++ G L + R R F P + A L F Sbjct: 465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRS--RFYAAEVTSALMF 522 Query: 210 LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYAAPE 389 LH+ VIYRD K NILLDAE + KL+DFG+ K+G T +T GT Y APE Sbjct: 523 LHQHG---VIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVT--TTTFCGTPDYIAPE 577 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGR 470 + D ++ GV++ EMM+G+ Sbjct: 578 ILQELEYGPSVDWWALGVLMYEMMAGQ 604
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 73.2 bits (178), Expect = 6e-13 Identities = 46/156 (29%), Positives = 84/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L + + +P I K++ Sbjct: 116 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KEAKRIPEDILGKVS 174 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + +GLA+L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 175 IAVLRGLAYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 228 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SD++S G+ L+E+ GR Sbjct: 229 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGR 264
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 72.8 bits (177), Expect = 8e-13 Identities = 52/154 (33%), Positives = 75/154 (48%), Gaps = 5/154 (3%) Frame = +3 Query: 27 NLQHPHLVKLVGYCIEDDQR-----LLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGA 191 N+ H+V Y D +V EF+ RG L R LP + + + A Sbjct: 74 NIDSEHVVATYDYREVPDPAGHTFCFIVMEFV-RGESLADLLEREGRLPEDLALDVMEQA 132 Query: 192 AKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTY 371 A GL+ +H +++RD K N+L+ A K++DFG+AK T V+GT Sbjct: 133 AHGLSVIHR---MDMVHRDIKPGNMLITANGIVKITDFGIAKAAAAVPLTRTGM-VVGTA 188 Query: 372 GYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRR 473 Y +PE +T+ SD+YS GVV EMM+GRR Sbjct: 189 QYVSPEQAQGKEVTAASDIYSLGVVGYEMMAGRR 222
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 72.8 bits (177), Expect = 8e-13 Identities = 44/156 (28%), Positives = 83/156 (53%), Gaps = 4/156 (2%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRS----FPLPWAIRMK 176 E++ + +L+H ++V ++G + + +++E+M G L L S L ++ Sbjct: 459 EIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQ 518 Query: 177 IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 IAL ++G+ +L + ++RD N L++ K+SDFGL++D D V ++ Sbjct: 519 IALQISEGMQYL---SAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSK 575 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + + E ++ G T++SDV+SFGVVL E+ S Sbjct: 576 SLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYS 611
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 72.8 bits (177), Expect = 8e-13 Identities = 45/157 (28%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP+++ L G + ++V E+M GSL+ L + + + Sbjct: 561 LGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGML 620 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G A G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 621 RGIAAGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 677 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E++S Sbjct: 678 KI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS 712
>DDR2_HUMAN (Q16832) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 855 Score = 72.8 bits (177), Expect = 8e-13 Identities = 43/158 (27%), Positives = 78/158 (49%), Gaps = 9/158 (5%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMK---- 176 E+ + L+ P+++ L+ CI DD ++ E+M G L L R P + ++ Sbjct: 625 EIKIMSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSY 684 Query: 177 -----IALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKT 341 +A A G+ +L + ++RD T N L+ Y K++DFG++++ GD Sbjct: 685 TNLKFMATQIASGMKYL---SSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 741 Query: 342 HVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLE 455 + R + + + E ++ G T+ SDV++FGV L E Sbjct: 742 RIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWE 779
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 72.8 bits (177), Expect = 8e-13 Identities = 46/171 (26%), Positives = 86/171 (50%), Gaps = 18/171 (10%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + EV + +L HP+++K +G +D + L+ E++ G+L++ L R P PW +++ A Sbjct: 374 LTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL-RSMDPFPWQQKVRFA 432 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK----DGPEGDKTHVS 350 G A G+A+LH +I+RD + N L+ + ++DFGL++ + + Sbjct: 433 KGIASGMAYLHSMC---IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKAT 489 Query: 351 TR--------------VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 T+ V+G + APE + D++SFG+VL E++ Sbjct: 490 TKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 540
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 72.8 bits (177), Expect = 8e-13 Identities = 44/156 (28%), Positives = 78/156 (50%), Gaps = 5/156 (3%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 EV + L+HPH++K +G +D + + E++P G+L + PW R+ A Sbjct: 359 EVKVMRCLEHPHVLKFIGVLYKDKRLNFITEYIPGGTLRRVIKSMDTHCPWNQRVSFARD 418 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR---- 356 A G+ +LH +I+RD + N L+ + +++FGL++ PE + R Sbjct: 419 IAAGMTYLH---SMNIIHRDLNSHNCLVREDGGLVVANFGLSRLIPEETRDLRKDRRKRY 475 Query: 357 -VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMM 461 V+G + APE + DV+SFG+V+ E++ Sbjct: 476 TVVGNPYWMAPEMINGRSYDESVDVFSFGIVICEII 511
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 72.8 bits (177), Expect = 8e-13 Identities = 53/147 (36%), Positives = 74/147 (50%), Gaps = 1/147 (0%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAAKGLAF 209 +HP+L +L D+ V E++ G L + R R F P + A L F Sbjct: 465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRS--RFYAAEVTSALMF 522 Query: 210 LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYAAPE 389 LH+ VIYRD K NILLDAE + KL+DFG+ K+G T +T GT Y APE Sbjct: 523 LHQHG---VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVT--TTTFCGTPDYIAPE 577 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGR 470 + D ++ GV++ EMM+G+ Sbjct: 578 ILQELEYGPSVDWWALGVLMYEMMAGQ 604
>KPCE_RABIT (P10830) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 736 Score = 72.8 bits (177), Expect = 8e-13 Identities = 53/147 (36%), Positives = 74/147 (50%), Gaps = 1/147 (0%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAAKGLAF 209 +HP+L +L D+ V E++ G L + R R F P + A L F Sbjct: 464 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRS--RFYAAEVTSALMF 521 Query: 210 LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYAAPE 389 LH+ VIYRD K NILLDAE + KL+DFG+ K+G T +T GT Y APE Sbjct: 522 LHQHG---VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVT--TTTFCGTPDYIAPE 576 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGR 470 + D ++ GV++ EMM+G+ Sbjct: 577 ILQELEYGPSVDWWALGVLMYEMMAGQ 603
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 72.4 bits (176), Expect = 1e-12 Identities = 49/152 (32%), Positives = 76/152 (50%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E + L+HP L++L C +++ +V E M GSL +L L + +A Sbjct: 283 EASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQ 342 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+++L ++ I+RD NIL+ K++DFGLA+ E + T Sbjct: 343 VASGMSYLEQQN---YIHRDLAARNILVGEHGICKVADFGLARVIDE-EIYEAHTGAKFP 398 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE M T KSDV+SFGVVL E+++ Sbjct: 399 IKWTAPEAAMYNRFTIKSDVWSFGVVLYEIIT 430
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/183 (27%), Positives = 89/183 (48%), Gaps = 9/183 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E++ L NL+H H+ +L ++ +V E+ P G L +++ + R+ + Sbjct: 57 EIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRV-VFRQ 115 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 +A++H + +RD K N+L D + KL DFGL P+G+K + G+ Sbjct: 116 IVSAVAYVHSQG---YAHRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGS 171 Query: 369 YGYAAPEYVM-TGHLTSKSDVYSFGVVLLEMMSGRRSMD--------KNRPNGEHNLVEW 521 YAAPE + +L S++DV+S G++L +M G D K G++++ +W Sbjct: 172 LAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKW 231 Query: 522 ARP 530 P Sbjct: 232 LSP 234
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/156 (29%), Positives = 83/156 (53%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E+ L P++V G D + + E M GSL+ L + + +P I K++ Sbjct: 113 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KEARRIPEEILGKVS 171 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 + +GL +L E+ + +++RD K SNIL+++ KL DFG++ + ++ + Sbjct: 172 IAVLRGLVYLREKHQ--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFV 225 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 GT Y +PE + H + +SDV+S G+ L+E+ GR Sbjct: 226 GTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGR 261
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/156 (32%), Positives = 87/156 (55%), Gaps = 2/156 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 +AE + + NLQHP LV+L + + ++ E+M +GSL + L + S + +I + Sbjct: 284 LAEANLMKNLQHPRLVRLYAV-VTKEPIYIITEYMEKGSLVDFL-KTSEGIKLSINKLLD 341 Query: 183 LGA--AKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTR 356 + A A+G+AF+ + I+RD + +NIL+ K++DFGLA+ + + T Sbjct: 342 MAAQIAEGMAFIEA---KNYIHRDLRAANILVSEALCCKIADFGLARLIEDNEYT-AREG 397 Query: 357 VMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + G T KSDV+SFG++L E+++ Sbjct: 398 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVT 433
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 72.4 bits (176), Expect = 1e-12 Identities = 45/152 (29%), Positives = 76/152 (50%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E +G HPH++ L G + +++ EFM G+L+ L R L + + G Sbjct: 673 EATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQG 732 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+ +L + ++RD NIL++ K+SDFGL + + D T+ + Sbjct: 733 IASGMNYL---SNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIP 789 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 + APE + T+ SDV+SFG+V+ E++S Sbjct: 790 IRWTAPEAIAHRIFTTASDVWSFGIVMWEVLS 821
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/183 (27%), Positives = 88/183 (48%), Gaps = 9/183 (4%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+D L +L+H H+ +L ++ +V E+ P G L +++ + R+ + Sbjct: 57 EIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRV-VFRQ 115 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 +A++H + +RD K N+L D + KL DFGL P+G+K + G+ Sbjct: 116 ILSAVAYVHSQG---YAHRDLKPENLLFDENHKLKLIDFGLCAK-PKGNKDYHLQTCCGS 171 Query: 369 YGYAAPEYVM-TGHLTSKSDVYSFGVVLLEMMSGRRSMD--------KNRPNGEHNLVEW 521 YAAPE + +L S++DV+S G++L +M G D K G++ + +W Sbjct: 172 LAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKW 231 Query: 522 ARP 530 P Sbjct: 232 LSP 234
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/147 (36%), Positives = 75/147 (51%), Gaps = 1/147 (0%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAAKGLAF 209 +HP+L +L D+ V E++ G L + R R F P + A L F Sbjct: 465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRS--GFYAAEVTSALMF 522 Query: 210 LHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYAAPE 389 LH+ VIYRD K NILLDAE ++KL+DFG+ K+G T +T GT Y APE Sbjct: 523 LHQHG---VIYRDLKLDNILLDAEGHSKLADFGMCKEGILNGVT--TTTFCGTPDYIAPE 577 Query: 390 YVMTGHLTSKSDVYSFGVVLLEMMSGR 470 + D ++ GV++ EMM+G+ Sbjct: 578 ILQELEYGPSVDWWALGVLMYEMMAGQ 604
>SGK3_MOUSE (Q9ERE3) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Cytokine independent survival kinase) Length = 496 Score = 72.4 bits (176), Expect = 1e-12 Identities = 58/151 (38%), Positives = 77/151 (50%), Gaps = 2/151 (1%) Frame = +3 Query: 21 LGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAA 194 L N++HP LV L Y + ++L V +F+ G L HL R RSFP P A A A Sbjct: 215 LKNVKHPFLVGL-HYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRA--RFYAAEIA 271 Query: 195 KGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYG 374 L +LH ++YRD K NILLD+ + L+DFGL K+G T +T GT Sbjct: 272 SALGYLHSIK---IVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDT--TTTFCGTPE 326 Query: 375 YAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 Y APE + + D + G VL EM+ G Sbjct: 327 YLAPEVIRKQPYDNTVDWWCLGAVLYEMLYG 357
>KPC1_DROME (P05130) Protein kinase C, brain isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(BR)) Length = 679 Score = 72.0 bits (175), Expect = 1e-12 Identities = 50/149 (33%), Positives = 77/149 (51%), Gaps = 1/149 (0%) Frame = +3 Query: 39 PHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFR-RSFPLPWAIRMKIALGAAKGLAFLH 215 P LV+L D+ V E++ G L + + F P A+ + A GL FLH Sbjct: 409 PFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAA--GLFFLH 466 Query: 216 EEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGTYGYAAPEYV 395 + ++YRD K N+LLDA+ + K++DFG+ K+ GDKT + GT Y APE + Sbjct: 467 TKG---ILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKT--TKTFCGTPDYIAPEII 521 Query: 396 MTGHLTSKSDVYSFGVVLLEMMSGRRSMD 482 + D +++GV+L EM+ G+ D Sbjct: 522 LYQPYGKSVDWWAYGVLLYEMLVGQPPFD 550
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 72.0 bits (175), Expect = 1e-12 Identities = 50/163 (30%), Positives = 80/163 (49%), Gaps = 1/163 (0%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E + L HP LV+L G C + +V EFM RG L N L +R + + + Sbjct: 410 IEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMC 469 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVM 362 +G+ +L + I+RD N L++ K+SDFG+A+ + D+ S+ Sbjct: 470 QDVCEGMEYLERNS---FIHRDLAARNCLVNEAGVVKVSDFGMARYVLD-DQYTSSSGAK 525 Query: 363 GTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS-GRRSMDKN 488 + PE +SKSDV+SFGV++ E+ + GR +KN Sbjct: 526 FPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKN 568
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 72.0 bits (175), Expect = 1e-12 Identities = 44/158 (27%), Positives = 79/158 (50%), Gaps = 9/158 (5%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLP---------W 161 E+ + L+ P++++L+ CI +D ++ E+M G L L R PL + Sbjct: 625 EIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHE-PLSSCSSDATVSY 683 Query: 162 AIRMKIALGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKT 341 A +A A G+ +L + ++RD T N L+ Y K++DFG++++ GD Sbjct: 684 ANLKFMATQIASGMKYL---SSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 740 Query: 342 HVSTRVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLE 455 + R + + + E ++ G T+ SDV++FGV L E Sbjct: 741 RIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWE 778
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 71.6 bits (174), Expect = 2e-12 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 3/157 (1%) Frame = +3 Query: 3 VAEVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIA 182 + E +G HP+++ L G + ++V E+M GSL+ L + + + Sbjct: 722 LGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGML 781 Query: 183 LGAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAK---DGPEGDKTHVST 353 G + G+ +L ++ ++RD NIL+++ K+SDFGL++ D PE T Sbjct: 782 RGISAGMKYL---SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 838 Query: 354 RVMGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMS 464 ++ + APE + TS SDV+S+G+V+ E++S Sbjct: 839 KI--PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS 873
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 71.6 bits (174), Expect = 2e-12 Identities = 53/148 (35%), Positives = 78/148 (52%), Gaps = 1/148 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRL-LVYEFMPRGSLENHLFRRSFPLPWAIRMKIAL 185 E D L ++ HP +VKL Y + + +L L+ +F+ G L L + ++ +A Sbjct: 112 ERDILADVNHPFVVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA- 169 Query: 186 GAAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMG 365 A GL LH +IYRD K NILLD E + KL+DFGL+K+ + +K S G Sbjct: 170 ELALGLDHLHSLG---IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS--FCG 224 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVL 449 T Y APE V T +D +S+GV++ Sbjct: 225 TVEYMAPEVVNRQGHTHSADWWSYGVLM 252 Score = 44.7 bits (104), Expect = 2e-04 Identities = 41/149 (27%), Positives = 68/149 (45%), Gaps = 4/149 (2%) Frame = +3 Query: 33 QHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALGAAKGLAFL 212 QHP+++ L + LV E M G L + + R+ F + +K + +L Sbjct: 457 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHT-ISKTVEYL 515 Query: 213 HEEAERPVIYRDFKTSNIL-LDAEYN---AKLSDFGLAKDGPEGDKTHVSTRVMGTYGYA 380 H + V++RD K SNIL +D N ++ DFG AK + + T T + Sbjct: 516 HSQG---VVHRDLKPSNILYVDESGNPECLRICDFGFAKQ-LRAENGLLMTPCY-TANFV 570 Query: 381 APEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 APE + D++S G++L M++G Sbjct: 571 APEVLKRQGYDEGCDIWSLGILLYTMLAG 599
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/165 (27%), Positives = 85/165 (51%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E+ L P++V G + + + EFM + SL+ ++++ P+ I KIA+ Sbjct: 155 ELQILHECNSPYIVSFYGAYLNEPHICMCMEFMQKDSLDG-IYKKYGPISPEICGKIAVA 213 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 + GL +L++ +I+RD K SNIL++ K+ DFG++ + ++ +GT Sbjct: 214 VSHGLTYLYDVHR--IIHRDVKPSNILVNGAGQIKICDFGVSGELINS----IADTFVGT 267 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGRRSMDKNRPNGE 503 Y +PE + + KSDV+S GV ++++ GR +N + + Sbjct: 268 STYMSPERIQGDQYSVKSDVWSLGVSIIDVALGRFPFAENEEDDD 312
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/155 (29%), Positives = 82/155 (52%), Gaps = 1/155 (0%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 E++ L L H ++V G E + E++P GS+ + L P ++ Sbjct: 525 EMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYG-PFEESLITNFTRQ 583 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKD-GPEGDKTHVSTRVMG 365 G+A+LH+ + +I+RD K +NIL+D + K++DFG++K P K + + G Sbjct: 584 ILIGVAYLHK---KNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQG 640 Query: 366 TYGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSGR 470 + + +PE V T+K+D++S G V++EM +G+ Sbjct: 641 SVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGK 675
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/153 (29%), Positives = 79/153 (51%) Frame = +3 Query: 9 EVDFLGNLQHPHLVKLVGYCIEDDQRLLVYEFMPRGSLENHLFRRSFPLPWAIRMKIALG 188 ++ L L+HP+++ G C + ++ E+ G L L R + + + + G Sbjct: 204 DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL-RAGRKITPRLLVDWSTG 262 Query: 189 AAKGLAFLHEEAERPVIYRDFKTSNILLDAEYNAKLSDFGLAKDGPEGDKTHVSTRVMGT 368 A G+ +LH +I+RD K+ N+L+ K+SDFG +K+ DK+ GT Sbjct: 263 IASGMNYLHLHK---IIHRDLKSPNVLVTHTDAVKISDFGTSKE--LSDKS-TKMSFAGT 316 Query: 369 YGYAAPEYVMTGHLTSKSDVYSFGVVLLEMMSG 467 + APE + ++ K D++SFGVVL E+++G Sbjct: 317 VAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTG 349 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 104,017,383 Number of Sequences: 219361 Number of extensions: 2399010 Number of successful extensions: 9604 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7571 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7998 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5881538857 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
