>TOP6B_SULSO (Q97ZF0) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 530

 Score =  127 bits (318), Expect = 4e-29
 Identities = 72/211 (34%), Positives = 126/211 (59%), Gaps = 2/211 (0%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAK-FDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEG 178
           LT +++ R+ + F++ + F  PS + LS  GE  + LG+ K  +PD  A+    P+ ++G
Sbjct: 288 LTEEEITRLVETFKKYEDFRSPSADSLSVIGEDLIELGLKKIFNPDFTASITRKPKAYQG 347

Query: 179 HPFIVEAGVSIGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQ 355
           HPFIVEAG++ GG   V +   + R+AN+IPL++++ +DVI +  ++ ++W  Y I   Q
Sbjct: 348 HPFIVEAGIAFGGSIPVGEEPIVLRYANKIPLIYDEKSDVIWK-VVEELDWKRYGIESDQ 406

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
            ++ V V + STKIP+K  GKE I  ++ +I   +K+AL +   +LK  + +K + +E +
Sbjct: 407 YQMVVMVHLCSTKIPYKSAGKESIA-EVEDIEKEIKNALMEVARKLKLYLSEKRKEQEAK 465

Query: 536 DRKRNLNKYIPDVARTIMETLGELADESPPK 628
            +     KY+P+V+R++   L     E  PK
Sbjct: 466 KKLLAYLKYVPEVSRSLAIFLASGNKELVPK 496

>TOP6B_SULSH (O05207) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 530

 Score =  126 bits (316), Expect = 7e-29
 Identities = 70/197 (35%), Positives = 121/197 (61%), Gaps = 2/197 (1%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAK-FDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEG 178
           LT +++ R+ + F++ + F  PS + LS  GE  + LG+ K  +PD  A+    P+ ++G
Sbjct: 288 LTEEEITRLVETFKKDEDFRSPSADSLSVIGEDLIELGLKKIFNPDFAASITRKPKAYQG 347

Query: 179 HPFIVEAGVSIGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQ 355
           HPFIVEAGV+ GG   V +   + R+AN+IPL++++ +DVI +  ++ ++W  Y I   Q
Sbjct: 348 HPFIVEAGVAFGGSIPVGEEPIVLRYANKIPLIYDEKSDVIWK-VVEELDWKRYGIESDQ 406

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
            ++ V V + STKIP+K  GKE I  ++  I   +K+AL +   +LK  + +K + +E +
Sbjct: 407 YQMVVMVHLCSTKIPYKSAGKESIA-EVENIEKEIKNALMEVARKLKQYLSEKRKEQEAK 465

Query: 536 DRKRNLNKYIPDVARTI 586
            +     KYIP+V+R++
Sbjct: 466 KKLLAYLKYIPEVSRSL 482

>TOP6B_SULTO (Q971T2) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 532

 Score =  124 bits (310), Expect = 3e-28
 Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 4/197 (2%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAKFDD---PSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVF 172
           LT +++ R+ ++ +  KFDD   PS   LS  GE  ++LG+    +P+        P+ +
Sbjct: 287 LTDEEISRLVEVMK--KFDDFRPPSAEALSVIGEDLIKLGLKSIFNPEFAEAITRKPKAY 344

Query: 173 EGHPFIVEAGVSIGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ 349
           +GHPFIVEAG++ GG         + R+AN+IPL++++ +DVI +   + ++W  Y I +
Sbjct: 345 QGHPFIVEAGIAYGGAIQPSPEPIVLRYANKIPLIYDEKSDVIWKVVTEEMDWKRYGIEE 404

Query: 350 QQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQARE 529
           +Q  + V V + STK+P++  GKE I  D+ EI   +K AL     +LK  I +K +  E
Sbjct: 405 EQPPLVVMVHLCSTKVPYRSAGKESIA-DVEEIEKEIKLALMDVARKLKKYITEKRKEEE 463

Query: 530 QQDRKRNLNKYIPDVAR 580
            + R     KYIP+V+R
Sbjct: 464 AKKRLITYLKYIPEVSR 480

>TOP6B_PYRAB (Q9V135) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 564

 Score =  119 bits (297), Expect = 1e-26
 Identities = 74/203 (36%), Positives = 116/203 (57%), Gaps = 2/203 (0%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH 181
           LT  +   I + F+  KF  P  + L P GE N++ G+   L P+ V     +P+V+ G 
Sbjct: 334 LTWHEAEEIVEAFKLMKFLAPPTHGLRPIGEENIKKGLTSILKPEFVTAVTRAPRVYAGG 393

Query: 182 -PFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ-QQ 355
            PF VE G++ GG+   QG  I R+ANR+PLLF+ G+ VIT +A++ I+W  YKI+    
Sbjct: 394 IPFQVEVGLAYGGQ--IQGSEILRYANRVPLLFDAGSCVIT-SAVRSIDWKRYKIDSFDS 450

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
             + V V++VS  +P+  TGK+ I  DI EI + ++ AL     +L   +  K +   Q 
Sbjct: 451 APLVVLVNVVSVHVPYTSTGKQSIA-DIDEIHNEIRLALMDAARRLSFYLGGKFRRMYQV 509

Query: 536 DRKRNLNKYIPDVARTIMETLGE 604
            R++ L KY+P++AR++    GE
Sbjct: 510 KRRKTLEKYLPEIARSLHILTGE 532

>TOP6B_PYRHO (O74020) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 564

 Score =  117 bits (294), Expect = 2e-26
 Identities = 74/203 (36%), Positives = 116/203 (57%), Gaps = 2/203 (0%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH 181
           LT Q+   I + F+  KF  P  + L P GE N++ G+   L P+ V     SP+V+ G 
Sbjct: 334 LTWQEAEEIVEAFKLMKFLAPPTHGLRPIGEENIKRGLTGILKPEFVTAVTRSPKVYAGG 393

Query: 182 -PFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ-QQ 355
            PF VE G++ GG+    G  I R+ANR+PLLF+ G+ VIT +A++ I+W  YKI+    
Sbjct: 394 IPFQVEVGLAYGGQ--ISGSEILRYANRVPLLFDAGSCVIT-SAVRSIDWKRYKIDSFDS 450

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
             + V V+++S  +P+  TGK+ I  DI EI + ++ AL     +L   +  K +   Q 
Sbjct: 451 APLVVLVNVISVHVPYTSTGKQSIA-DIEEIYNEIRLALMDAARKLALYLGGKYRRMYQI 509

Query: 536 DRKRNLNKYIPDVARTIMETLGE 604
            R++ L KY+P++AR++    GE
Sbjct: 510 KRRKTLEKYLPEIARSLHILTGE 532

>TOP6B_AERPE (Q9YE64) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 565

 Score =  117 bits (294), Expect = 2e-26
 Identities = 71/217 (32%), Positives = 117/217 (53%), Gaps = 1/217 (0%)
 Frame = +2

Query: 17  LVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVE 196
           L R+     +  F  P  + LSP G   + +G+ +  +P+ V   + SP+ + GHPFIVE
Sbjct: 319 LRRLADALMEYPFRAPKSDYLSPIGSDIIEIGLRRMFNPEWVGAVSRSPKAYRGHPFIVE 378

Query: 197 AGVSIGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDKIGVF 373
            G++ GG  + +    + R+AN+IPLL+E+  DV +   +  INW  Y ++     + V 
Sbjct: 379 VGIAYGGGIEARSEPLLLRYANKIPLLYEEREDV-SYKVVSSINWRQYNVDFPAPLV-VL 436

Query: 374 VSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNL 553
           V I STK+P+KG GKE +  D+ EI   +++A+++   +L+  + +K +  E   R   L
Sbjct: 437 VHIASTKVPYKGVGKESV-SDVPEIEAEIRNAVQEVARRLRLYLSRKAREEEAIRRSVTL 495

Query: 554 NKYIPDVARTIMETLGELADESPPKRPRFDKEDEELL 664
            KYIP+VA ++   L   +   PPK     K  E L+
Sbjct: 496 AKYIPEVAVSLAYFLRPPSKWQPPKPEEVKKIQEALI 532

>TOP6B_ARCFU (O29605) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 602

 Score =  116 bits (291), Expect = 5e-26
 Identities = 60/192 (31%), Positives = 110/192 (57%), Gaps = 5/192 (2%)
 Frame = +2

Query: 38  FRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSIGG 217
           FRQ  F  P  +CLSP GE  +   ++ E  P+ V      P+V+ GHPF+VE G++ GG
Sbjct: 295 FRQTDFLPPPTDCLSPIGEAMIAKSLMAEFQPEFVYAVTRKPKVYSGHPFLVEVGLAYGG 354

Query: 218 KDVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDKIG-----VFVSI 382
           +   + + + R+AN+IPLL++QG   +T+ A++ +NW  Y + Q + ++      + + +
Sbjct: 355 EIKSEKVTLLRYANKIPLLYQQGGCALTK-AVESVNWKSYGMVQNRGELPSAPAVILIHL 413

Query: 383 VSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKY 562
            ST IP+    KE +   I EI D  + AL++   +LK  + +K + ++++ ++  + K 
Sbjct: 414 ASTNIPYTSESKESVA-AIPEIIDETRLALQEVGRRLKEYLERKSRQQKKKKKEEMIGKV 472

Query: 563 IPDVARTIMETL 598
           +P +A+ + E L
Sbjct: 473 LPLIAKKVCEIL 484

>TOP6B_PYRKO (Q5JH81) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 567

 Score =  114 bits (285), Expect = 3e-25
 Identities = 66/203 (32%), Positives = 115/203 (56%), Gaps = 2/203 (0%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH 181
           LT  +   I + F+  KF  P  + L P GE N+  G+   L P+ V      P+V+ G 
Sbjct: 334 LTWHEAEEIVEAFKYMKFLAPPTHGLRPIGEENIEKGLKGILKPEFVTAVTRPPKVYSGG 393

Query: 182 -PFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ-QQ 355
            PF VE G++ GG ++  G +++R+ANR+PLLF+ G+ V T+ A + I+W  YKI+   +
Sbjct: 394 IPFQVEVGIAYGG-EIPAGFDLYRYANRVPLLFDAGSCVTTQAA-RSIDWKRYKIDDLDR 451

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
             + + +++VS  +P+ GTGK+ I   + EI + ++ A+     +L++ +  K +   Q 
Sbjct: 452 APLVLMINVVSVHVPYTGTGKQSIA-SVDEIYNEIRLAIMDAARRLQTYLSGKHRKLAQV 510

Query: 536 DRKRNLNKYIPDVARTIMETLGE 604
            R++   KY+P++AR +    GE
Sbjct: 511 KRRKTFEKYVPEIARALSILTGE 533

>TOP6B_METAC (Q8TQF7) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 621

 Score =  109 bits (273), Expect = 6e-24
 Identities = 63/198 (31%), Positives = 110/198 (55%), Gaps = 6/198 (3%)
 Frame = +2

Query: 23  RIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAG 202
           ++ + F++ K   P  +CLSP GE  +  G+ KE + D +AT    P V+ G+PF+VE G
Sbjct: 299 KLIEAFQKVKIMSPPTDCLSPIGEELIYRGLEKETNVDFIATSTRKPAVYSGNPFVVEVG 358

Query: 203 VSIGGKDVK-QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDKIGV--- 370
           ++ GG   K + ++I RFANR+PLL++QG  V T  A++ I W  Y +NQ    + +   
Sbjct: 359 LAYGGNLPKEEKISIMRFANRVPLLYQQGGCVTTH-AVEDIRWKQYGLNQPGGGVPIGPV 417

Query: 371 --FVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRK 544
              + + S  +PF    K+ I  DI  I + V  A+K+   +LK  + K+   +++++++
Sbjct: 418 LLLIHVASINVPFTSESKDAIA-DIPVIKEEVDLAVKEVARKLKHYLSKQSNLKKRREKE 476

Query: 545 RNLNKYIPDVARTIMETL 598
             + K +P +A  +   L
Sbjct: 477 IIITKVLPKMAVKVANIL 494

>TOP6B_METMA (Q8PUB8) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 621

 Score =  108 bits (271), Expect = 1e-23
 Identities = 64/198 (32%), Positives = 108/198 (54%), Gaps = 6/198 (3%)
 Frame = +2

Query: 23  RIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAG 202
           ++ + F + K   P  +CLSP GE  +  G+ KE   D +AT    P V+ G+PF+VE G
Sbjct: 299 KLIEAFEKVKIMAPPTDCLSPIGEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVG 358

Query: 203 VSIGGKDVK-QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDKIGV--- 370
           ++ GG   K + ++I RFANR+PLL++QG  V T  A++ I W  Y +NQ    I V   
Sbjct: 359 MAYGGNLPKEEKISIMRFANRVPLLYQQGGCVTTH-AVEDIKWKQYGLNQPGGGIPVGPV 417

Query: 371 --FVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRK 544
              + + S  +PF    K+ I  DI  I + +  A+K+   +LK  + K+   +++++++
Sbjct: 418 ILLIHVASINVPFTSESKDAIA-DIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKE 476

Query: 545 RNLNKYIPDVARTIMETL 598
             + K +P +A  +   L
Sbjct: 477 IIITKVLPKLAAKVAHVL 494

>TOP6B_PYRFU (Q8U0K8) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 568

 Score =  107 bits (268), Expect = 2e-23
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 2/203 (0%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH 181
           LT  +   I + F+  KF  P    L P GE N+  G+   L P+ V      P+V+ G 
Sbjct: 336 LTWHEAEEIVEAFKLMKFLAPPTYGLRPIGEENIEKGLSSILRPEFVTAVTRPPKVYSGG 395

Query: 182 -PFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ-QQ 355
            PF VE G++ GG+       I R+ANR+PLLF+ G+ VIT +A++ I+W  Y++     
Sbjct: 396 IPFQVEVGIAYGGEITNS--EILRYANRVPLLFDAGSCVIT-SAVRSIDWRRYRVESFDN 452

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
             + V V++VS  +P+  TGK+ I   I EI + ++ AL +   +L + +  K +   Q 
Sbjct: 453 APLVVLVNVVSVHVPYTSTGKQSIA-SIDEIYNEIRLALMEAARRLAAYLGGKYRRLYQI 511

Query: 536 DRKRNLNKYIPDVARTIMETLGE 604
            RK+   KY+P++AR++    GE
Sbjct: 512 RRKKIFEKYLPEIARSLHILTGE 534

>TOP6B_PYRAE (Q8ZVM0) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 527

 Score =  100 bits (250), Expect = 3e-21
 Identities = 65/194 (33%), Positives = 107/194 (55%), Gaps = 2/194 (1%)
 Frame = +2

Query: 2   LTSQQLVRIHQLFRQAK-FDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEG 178
           LT ++LV++    +Q + +  P  + LSPAG   L +G    L  + V      P+ + G
Sbjct: 283 LTPEELVKLVDKMKQYEGWRRPRSDWLSPAGAELLEIGAKAILGAEAVFAITRKPESYGG 342

Query: 179 HPFIVEAGVSIGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQ 355
           HPFIVEA V+ GG+        + R+AN+IPLL+++GADV  R  +   NW  YK+ +  
Sbjct: 343 HPFIVEAAVAWGGQIPPADKPLLLRYANKIPLLYDEGADV-ARKVVDEFNWQNYKV-KFP 400

Query: 356 DKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQ 535
             + V + + STKIP+   GKE I  ++ EI   +K AL+    +L+  + +K +  E  
Sbjct: 401 APLAVIIHVCSTKIPYASAGKEAIA-EVPEIEKEMKLALRDAAKKLRLYLSRKEKEMEML 459

Query: 536 DRKRNLNKYIPDVA 577
           ++  +L KY+ ++A
Sbjct: 460 NKYISLAKYVEEIA 473

>TOP6B_METTH (O27088) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
           (TopoVI-B)
          Length = 523

 Score =  100 bits (248), Expect = 5e-21
 Identities = 65/212 (30%), Positives = 109/212 (51%), Gaps = 7/212 (3%)
 Frame = +2

Query: 11  QQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH-PF 187
           ++  +I + F++ KF  P  + L P GE  +  G+ + L P+  AT    P+ + G   F
Sbjct: 295 EEAEQIVEAFKKMKFMSPPTSGLIPIGEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAF 354

Query: 188 IVEAGVSIGGKDVK-----QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQ 352
           IVEAG++ GG   +     +   I RFANR+PL F+ G+  IT   +K ++W  Y I   
Sbjct: 355 IVEAGIAYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITE-GVKSLDWKRYGIRDL 413

Query: 353 QDK-IGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQARE 529
           ++  I +FV++VST +P+  TGK+ +  +  EI   ++ A      +L   + KK  A+E
Sbjct: 414 ENAPISIFVNVVSTNVPYLSTGKQSVSPE-PEILGEIRQATMIVARKLHKYLRKKKAAKE 472

Query: 530 QQDRKRNLNKYIPDVARTIMETLGELADESPP 625
           +  R +    Y+P     I++    LA+   P
Sbjct: 473 EAQRAKIFESYVP----VIIKQAALLAEREEP 500

>TOP6B_METJA (Q58434) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
            (TopoVI-B)
          Length = 660

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 64/214 (29%), Positives = 111/214 (51%), Gaps = 9/214 (4%)
 Frame = +2

Query: 2    LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH 181
            LT  +   I    +  +F  P    L P G  N+   + + L PD V     +P+ ++G 
Sbjct: 438  LTWDEAEMIVNCLQSMEFMAPPTTGLRPIGAENIEKSLKELLQPDFVKAITRNPKTYKGG 497

Query: 182  -PFIVEAGVSIGGKDVKQG-----LNIFRFANRIPLLFEQGADVITRTALKRINWSIYKI 343
             PF VE  ++ GG   +QG     + I RFAN +PLL++  A  +T+ A+K INW  Y +
Sbjct: 498  IPFAVEVAIAYGGNAGRQGDEGRRMEIMRFANHVPLLYDASACGLTK-AVKSINWKRYGL 556

Query: 344  NQQQDKIGVFVSIVSTKIPFKGTGKEYIG---DDITEIADAVKSALKQCCVQLKSKIVKK 514
              +   I VFV+++ST IP+   GK+ +    ++  EI + ++ AL  C  +L+ K + +
Sbjct: 557  RGEDAPITVFVNLISTFIPYTSAGKQAVACSENENEEIYNEIRHALMICGRELE-KYLSR 615

Query: 515  LQAREQQDRKRNLNKYIPDVARTIMETLGELADE 616
            ++   ++++KR   KY+   AR   E L  + ++
Sbjct: 616  IRREAEEEKKR---KYVMKYARIFAEALANILNK 646

>TOP6B_HALSA (Q9HR31) Type II DNA topoisomerase VI subunit B (EC 5.99.1.3)|
            (TopoVI-B)
          Length = 804

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 62/189 (32%), Positives = 97/189 (51%), Gaps = 7/189 (3%)
 Frame = +2

Query: 62   PSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGK-DVKQGL 238
            P  +CLSP     L  G+  E   D  A       V  G PFIVEAG++ GG  D + G+
Sbjct: 505  PPTSCLSPIEADQLEAGLRTEFDADFYAAATRDADVHGGDPFIVEAGIAYGGDIDSEGGV 564

Query: 239  NIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ------QQDKIGVFVSIVSTKIP 400
             + RFANR+PL++++GA   T   L  I W  Y ++Q       Q    + V + ST +P
Sbjct: 565  QLMRFANRVPLVYQRGA-CATTDVLGDIGWRNYNLSQPGGSGLPQGPAVIMVHVASTNVP 623

Query: 401  FKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVAR 580
            F    K+ I  ++ EI   ++ A+++   +LKS + K+   R++Q ++      I D+  
Sbjct: 624  FTSESKDAIA-NVPEIEAEIELAVREAARELKSFLQKRQSMRKRQQKQ----DVIMDILP 678

Query: 581  TIMETLGEL 607
            T+ E +GEL
Sbjct: 679  TMAEKVGEL 687

>DOCK1_HUMAN (Q14185) Dedicator of cytokinesis protein 1 (180 kDa protein|
            downstream of CRK) (DOCK180)
          Length = 1865

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 27/110 (24%), Positives = 50/110 (45%), Gaps = 11/110 (10%)
 Frame = +2

Query: 347  QQQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR 526
            +  +KI     +++ +IPF   G    GD +TE        ++ C  QLK K+ K+   R
Sbjct: 1556 EAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVR 1615

Query: 527  --------EQQDRKRNLNK--YIPDVARTI-METLGELADESPPKRPRFD 643
                     +  R R++ +   +P  +R + + ++  L+ +S P RP  D
Sbjct: 1616 IMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSD 1665

>DOCK2_HUMAN (Q92608) Dedicator of cytokinesis protein 2|
          Length = 1830

 Score = 34.3 bits (77), Expect = 0.35
 Identities = 26/112 (23%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
 Frame = +2

Query: 347  QQQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR 526
            + QDK+     +++ +IPF G G +     +++        +++C   LK K+ K+   R
Sbjct: 1561 EDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVR 1620

Query: 527  EQQD-------RKRNLNKYIPDVARTIMETLGELADESPPKRPRFDKEDEEL 661
            E  D       R R++ +    +  +I+      +D S P +P  +  D EL
Sbjct: 1621 EMPDFDDRRVGRPRSMLRSYRQM--SIISLASMNSDCSTPSKPTSESFDLEL 1670

>DOCK1_MOUSE (Q8BUR4) Dedicator of cytokinesis protein 1 (180 kDa protein|
            downstream of CRK) (DOCK180) (Fragments)
          Length = 1027

 Score = 33.5 bits (75), Expect = 0.59
 Identities = 24/99 (24%), Positives = 45/99 (45%), Gaps = 11/99 (11%)
 Frame = +2

Query: 380  IVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR--------EQQ 535
            +++ +IPF   G    GD +TE        ++ C  QLK K+ K+   R         + 
Sbjct: 729  LIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKQYGVRTMPSGLDDRRG 788

Query: 536  DRKRNLNK--YIPDVARTI-METLGELADESPPKRPRFD 643
             R R++ +   +P  +R + + ++   + +S P RP  D
Sbjct: 789  SRPRSMVRSFTMPSSSRPLSVASVSSFSSDSTPSRPGSD 827

>IMDH_TRIFO (P50097) Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP|
           dehydrogenase) (IMPDH) (IMPD)
          Length = 503

 Score = 33.5 bits (75), Expect = 0.59
 Identities = 33/119 (27%), Positives = 50/119 (42%), Gaps = 3/119 (2%)
 Frame = +2

Query: 224 VKQGLNIFRFANRIPLLFEQGADVITRTALKRIN-WSIYKINQQQDKIGVFVSIVSTKIP 400
           V  G+N   F  R+P L E GADV+   +    + W    I   ++K G  V + +  I 
Sbjct: 234 VGAGINTRDFRERVPALVEAGADVLCIDSSDGFSEWQKITIGWIREKYGDKVKVGAGNI- 292

Query: 401 FKGTGKEYIGDDITEIADAVKSAL--KQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPD 571
             G G  Y+ D     AD +K  +     C+  + K + + QA    D     NKY  +
Sbjct: 293 VDGEGFRYLAD---AGADFIKIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEE 348

>DOCK2_MOUSE (Q8C3J5) Dedicator of cytokinesis protein 2 (Hch protein)|
          Length = 1828

 Score = 33.1 bits (74), Expect = 0.77
 Identities = 16/64 (25%), Positives = 31/64 (48%)
 Frame = +2

Query: 347  QQQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR 526
            + QDK+     +++ +IPF G G +     +++        +++C   LK K+ K+   R
Sbjct: 1560 EDQDKLSHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVR 1619

Query: 527  EQQD 538
            E  D
Sbjct: 1620 EMPD 1623

>PCDG8_PANTR (Q5DRB2) Protocadherin gamma A8 precursor (PCDH-gamma-A8)|
          Length = 932

 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 5/89 (5%)
 Frame = +2

Query: 116 IKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGKDV-KQGLNIFRFANRIPLLFEQGAD 292
           + +  P+++ T   SP +    P  V A +S+  +D  K G  +    + +P   E+  D
Sbjct: 340 VNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCHTRDNLPFKLEKSID 399

Query: 293 ----VITRTALKRINWSIYKINQQQDKIG 367
               ++TR  L R N SIY I      +G
Sbjct: 400 NYYRLVTRKYLDRENVSIYNITVMASDLG 428

>CEF1_CRYNE (Q5K9L1) Pre-mRNA-splicing factor CEF1|
          Length = 838

 Score = 31.6 bits (70), Expect = 2.2
 Identities = 32/105 (30%), Positives = 48/105 (45%), Gaps = 11/105 (10%)
 Frame = +2

Query: 335 YKINQQQDKIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVK-----SALKQCCVQLKS 499
           Y + ++Q K+     + ST    +G  K+ + D+I E     K     S   Q  V  + 
Sbjct: 234 YDVTEEQAKVHA-APVGSTLRALEGKRKQEL-DEIEERKKRQKKGDGKSNQTQQFVAARE 291

Query: 500 KIVKKLQAREQQDRKRNLNKYIPDVARTIMETL------GELADE 616
             +KKL+ +EQ  R+R LN  IP V    +E +      GELA E
Sbjct: 292 AQIKKLKEQEQIIRRRKLNLPIPQVGERELEDIVKIGQAGELARE 336

>NU2C_SYNP7 (P29801) NAD(P)H-quinone oxidoreductase chain 2 (EC 1.6.5.-)|
           (NAD(P)H dehydrogenase I, chain 2) (NDH-1, chain 2)
          Length = 521

 Score = 31.2 bits (69), Expect = 2.9
 Identities = 20/58 (34%), Positives = 26/58 (44%)
 Frame = +2

Query: 140 VATHASSPQVFEGHPFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADVITRTAL 313
           V  H  +P V+EG P  + A +S+G K     L I       P L EQ   V T  A+
Sbjct: 227 VPFHQWTPDVYEGSPTPIVAFLSVGSKAAGFALAIRLLVTAYPALTEQWHFVFTALAI 284

>NU2C_SYNP6 (Q5N5T8) NAD(P)H-quinone oxidoreductase chain 2 (EC 1.6.5.-)|
           (NAD(P)H dehydrogenase I, chain 2) (NDH-1, chain 2)
          Length = 521

 Score = 31.2 bits (69), Expect = 2.9
 Identities = 20/58 (34%), Positives = 26/58 (44%)
 Frame = +2

Query: 140 VATHASSPQVFEGHPFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADVITRTAL 313
           V  H  +P V+EG P  + A +S+G K     L I       P L EQ   V T  A+
Sbjct: 227 VPFHQWTPDVYEGSPTPIVAFLSVGSKAAGFALAIRLLVTAYPALTEQWHFVFTALAI 284

>CCND2_XENLA (P53782) G1/S-specific cyclin-D2|
          Length = 291

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
 Frame = +2

Query: 428 GDDITEIADAVKSA----LKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDV 574
           GD +TE    + S     LK C  Q++S +V  L+   QQ ++RN +K + ++
Sbjct: 225 GDSLTEHLAKITSTDVDCLKACQEQIESVLVSSLRQTRQQTQQRNSSKSVDEL 277

>Y827_PYRFU (Q8U2K7) Hypothetical RNA methyltransferase PF0827 (EC 2.1.1.-)|
          Length = 409

 Score = 30.4 bits (67), Expect = 5.0
 Identities = 32/122 (26%), Positives = 48/122 (39%), Gaps = 12/122 (9%)
 Frame = +2

Query: 68  GNCLSPAGEYNLRLGIIKELHPDLVATHAS---SPQVFEGHP---FIVEAGVSIGGKDVK 229
           G CL    +Y  +L   KEL   +    A    SP+++E      FIV     IG K+  
Sbjct: 68  GGCLWQGMKYEEQLKFKKELFRRITGIEAEILGSPRIWEFRNISNFIVSVN-GIGLKEFA 126

Query: 230 QGLNIFR------FANRIPLLFEQGADVITRTALKRINWSIYKINQQQDKIGVFVSIVST 391
           +   +        F+NR PL      + +  + LK  NW    ++  Q + G F   V  
Sbjct: 127 RPKTVVDLKECPVFSNRTPLYIRAMKEFLRESGLKPWNWKEGDVHYLQVREGKFTGEVMV 186

Query: 392 KI 397
            I
Sbjct: 187 NI 188

>MYH11_RAT (Q63862) Myosin-11 (Myosin heavy chain, smooth muscle isoform)|
            (SMMHC) (Fragments)
          Length = 1327

 Score = 30.0 bits (66), Expect = 6.5
 Identities = 19/61 (31%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
 Frame = +2

Query: 437  ITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDR-KRNLNKYIPDVARTIMETLGELAD 613
            + E+  AVK+ LK     L++KIV+  +  EQ+ R K+   K +    + + E L ++ D
Sbjct: 1156 LQEVEGAVKAKLKSTVAALEAKIVQLEEQIEQEAREKQAATKLLKQKDKKLKEVLLQVED 1215

Query: 614  E 616
            E
Sbjct: 1216 E 1216


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,797,802
Number of Sequences: 219361
Number of extensions: 1965782
Number of successful extensions: 5743
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 5528
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5706
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6427774254
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)