ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags22a11 |
|---|---|
| Clone Library Name | barley_pub |
>KC1D_ARATH (P42158) Casein kinase I isoform delta-like (EC 2.7.11.1)| (CKI-delta) Length = 450 Score = 363 bits (933), Expect = e-100 Identities = 165/197 (83%), Positives = 186/197 (94%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSRK SLK+VLMLADQMINRVE+ H K FLHRD+KPDNFLMGLGR+ANQVYIID+GLA Sbjct: 94 NFCSRKLSLKSVLMLADQMINRVEFFHSKSFLHRDLKPDNFLMGLGRRANQVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD TH+HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGY+LMYFL+GSLPW Sbjct: 154 KKYRDSTTHQHIPYRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYILMYFLKGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKAGTKKQKY++ISEKK+ T +E LC+ YPSEF SYFHYCRSLRF+DKPDY+YLKR+F Sbjct: 214 QGLKAGTKKQKYERISEKKVSTSIEALCRGYPSEFASYFHYCRSLRFDDKPDYAYLKRIF 273 Query: 542 RDLFIREGYQFDYVFDW 592 RDLFIREG+QFDYVFDW Sbjct: 274 RDLFIREGFQFDYVFDW 290
>KC1D_RAT (Q06486) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| Length = 415 Score = 346 bits (887), Expect = 3e-95 Identities = 155/197 (78%), Positives = 183/197 (92%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSRKFSLKTVL+LADQMI+R+EY+H K F+HRD+KPDNFLMGLG+K N VYIID+GLA Sbjct: 94 NFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +TH+HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVLMYF GSLPW Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TK+QKY++ISEKKM TP+EVLCK YPSEF +Y ++CRSLRF+DKPDYSYL++LF Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 R+LF R+G+ +DYVFDW Sbjct: 274 RNLFHRQGFSYDYVFDW 290
>KC1D_MOUSE (Q9DC28) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 346 bits (887), Expect = 3e-95 Identities = 155/197 (78%), Positives = 183/197 (92%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSRKFSLKTVL+LADQMI+R+EY+H K F+HRD+KPDNFLMGLG+K N VYIID+GLA Sbjct: 94 NFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +TH+HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVLMYF GSLPW Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TK+QKY++ISEKKM TP+EVLCK YPSEF +Y ++CRSLRF+DKPDYSYL++LF Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 R+LF R+G+ +DYVFDW Sbjct: 274 RNLFHRQGFSYDYVFDW 290
>KC1D_HUMAN (P48730) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 346 bits (887), Expect = 3e-95 Identities = 155/197 (78%), Positives = 183/197 (92%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSRKFSLKTVL+LADQMI+R+EY+H K F+HRD+KPDNFLMGLG+K N VYIID+GLA Sbjct: 94 NFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +TH+HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVLMYF GSLPW Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TK+QKY++ISEKKM TP+EVLCK YPSEF +Y ++CRSLRF+DKPDYSYL++LF Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 R+LF R+G+ +DYVFDW Sbjct: 274 RNLFHRQGFSYDYVFDW 290
>KC1E_MOUSE (Q9JMK2) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 345 bits (886), Expect = 4e-95 Identities = 155/197 (78%), Positives = 183/197 (92%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSRKFSLKTVL+LADQMI+R+EY+H K F+HRD+KPDNFLMGLG+K N VYIID+GLA Sbjct: 94 NFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +TH+HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVLMYF GSLPW Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TK+QKY++ISEKKM TP+EVLCK YPSEF +Y ++CRSLRF+DKPDYSYL++LF Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 R+LF R+G+ +DYVFDW Sbjct: 274 RNLFHRQGFSYDYVFDW 290
>KC1E_HUMAN (P49674) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 345 bits (886), Expect = 4e-95 Identities = 155/197 (78%), Positives = 183/197 (92%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSRKFSLKTVL+LADQMI+R+EY+H K F+HRD+KPDNFLMGLG+K N VYIID+GLA Sbjct: 94 NFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +TH+HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVLMYF GSLPW Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TK+QKY++ISEKKM TP+EVLCK YPSEF +Y ++CRSLRF+DKPDYSYL++LF Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 R+LF R+G+ +DYVFDW Sbjct: 274 RNLFHRQGFSYDYVFDW 290
>KC1_TOXGO (Q6QNM1) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 332 bits (852), Expect = 4e-91 Identities = 149/195 (76%), Positives = 177/195 (90%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+RK SLKTVLMLADQM+NR+E++H K F+HRDIKPDNFL+G G+K + VYIID+GLAKK Sbjct: 96 CNRKLSLKTVLMLADQMLNRIEFVHSKNFIHRDIKPDNFLIGRGKKMSVVYIIDFGLAKK 155 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +RD +T +HIPYRE KNLTGTARYAS+NTHLG+EQSRRDDLE+LGYVLMYF RGSLPWQG Sbjct: 156 YRDPKTQQHIPYREGKNLTGTARYASINTHLGIEQSRRDDLEALGYVLMYFNRGSLPWQG 215 Query: 368 LKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 LKA TKK KYDKI EKKM TP+E+LCK +P EFI+Y +YCRSLRFED+PDY+YL+RLF+D Sbjct: 216 LKATTKKDKYDKIMEKKMSTPIEILCKHFPFEFITYLNYCRSLRFEDRPDYAYLRRLFKD 275 Query: 548 LFIREGYQFDYVFDW 592 LF REGYQ+D++FDW Sbjct: 276 LFFREGYQYDFIFDW 290
>HHP1_SCHPO (P40235) Casein kinase I homolog hhp1 (EC 2.7.11.1)| Length = 365 Score = 331 bits (849), Expect = 8e-91 Identities = 149/197 (75%), Positives = 178/197 (90%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+C+RKFSLKTVL+LADQ+I+R+E++H K FLHRDIKPDNFLMG+G++ NQV IID+GLA Sbjct: 96 NFCNRKFSLKTVLLLADQLISRIEFIHSKSFLHRDIKPDNFLMGIGKRGNQVNIIDFGLA 155 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +TH HIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVL+YF RGSLPW Sbjct: 156 KKYRDHKTHLHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLVYFCRGSLPW 215 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KI EKK+ TP EVLC+ +P EF Y +Y RSLRF+DKPDY+YL++LF Sbjct: 216 QGLKATTKKQKYEKIMEKKISTPTEVLCRGFPQEFSIYLNYTRSLRFDDKPDYAYLRKLF 275 Query: 542 RDLFIREGYQFDYVFDW 592 RDLF R+ Y+FDY+FDW Sbjct: 276 RDLFCRQSYEFDYMFDW 292
>KC1_EIMTE (Q6QNL9) Casein kinase I (EC 2.7.11.1)| Length = 335 Score = 328 bits (842), Expect = 6e-90 Identities = 149/195 (76%), Positives = 175/195 (89%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+RK SLKTVLMLADQM+NR+E++H + F+HRDIKPDNFL+G G+K + V+ ID+GLAKK Sbjct: 96 CNRKLSLKTVLMLADQMLNRIEFVHSRHFIHRDIKPDNFLIGRGKKMSIVFAIDFGLAKK 155 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +RD +T HIPYRE KNLTGTARYASVNTHLG+EQSRRDDLE+LGYVLMYF RGSLPWQG Sbjct: 156 YRDPRTQSHIPYREGKNLTGTARYASVNTHLGIEQSRRDDLEALGYVLMYFNRGSLPWQG 215 Query: 368 LKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 LKA TKK KYDKI EKKM TP+EVLCK +P EFI+Y +YCRSLRFED+PDYSYL+RLF+D Sbjct: 216 LKATTKKDKYDKIMEKKMSTPIEVLCKQFPFEFITYLNYCRSLRFEDRPDYSYLRRLFKD 275 Query: 548 LFIREGYQFDYVFDW 592 LF REGYQ+D++FDW Sbjct: 276 LFFREGYQYDFIFDW 290
>KC1A_SHEEP (P67829) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_RAT (P97633) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_RABIT (P67828) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_BOVIN (P67827) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_XENLA (P67963) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_MOUSE (Q8BK63) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_HUMAN (P48729) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1A_CHICK (P67962) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 317 bits (813), Expect = 1e-86 Identities = 143/197 (72%), Positives = 173/197 (87%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>KC1_PLAYO (Q7RBX5) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 317 bits (811), Expect = 2e-86 Identities = 141/195 (72%), Positives = 174/195 (89%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+RKFSLKTVLM ADQM+NR+EY+H K F+HRDIKPDNFL+G G+K ++IID+GLAKK Sbjct: 96 CNRKFSLKTVLMTADQMLNRIEYVHSKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKK 155 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +RD ++H HIPY+E KNLTGTARYAS+NTHLG+EQSRRDD+E+LGYVLMYFLRGSLPWQG Sbjct: 156 YRDSRSHTHIPYKEGKNLTGTARYASINTHLGIEQSRRDDIEALGYVLMYFLRGSLPWQG 215 Query: 368 LKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 LKA +KK KYDKI EKK+ T VEVLC++ EF++Y +YCRSLRFED+PDY+YL+RL +D Sbjct: 216 LKAISKKDKYDKIMEKKISTSVEVLCRNTSFEFVTYLNYCRSLRFEDRPDYTYLRRLLKD 275 Query: 548 LFIREGYQFDYVFDW 592 LFIREG+ +D++FDW Sbjct: 276 LFIREGFTYDFLFDW 290
>KC1_PLAF7 (Q8IHZ9) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 317 bits (811), Expect = 2e-86 Identities = 141/195 (72%), Positives = 174/195 (89%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+RKFSLKTVLM ADQM+NR+EY+H K F+HRDIKPDNFL+G G+K ++IID+GLAKK Sbjct: 96 CNRKFSLKTVLMTADQMLNRIEYVHSKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKK 155 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +RD ++H HIPY+E KNLTGTARYAS+NTHLG+EQSRRDD+E+LGYVLMYFLRGSLPWQG Sbjct: 156 YRDSRSHTHIPYKEGKNLTGTARYASINTHLGIEQSRRDDIEALGYVLMYFLRGSLPWQG 215 Query: 368 LKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 LKA +KK KYDKI EKK+ T VEVLC++ EF++Y +YCRSLRFED+PDY+YL+RL +D Sbjct: 216 LKAISKKDKYDKIMEKKISTSVEVLCRNASFEFVTYLNYCRSLRFEDRPDYTYLRRLLKD 275 Query: 548 LFIREGYQFDYVFDW 592 LFIREG+ +D++FDW Sbjct: 276 LFIREGFTYDFLFDW 290
>DCO_DROME (O76324) Discs overgrown protein kinase (EC 2.7.11.1) (Protein| double-time) Length = 440 Score = 316 bits (809), Expect = 4e-86 Identities = 140/197 (71%), Positives = 175/197 (88%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+FSLKTVL+LADQMI+R++Y+H + F+HRDIKPDNFLMGLG+K N VYIID+GLA Sbjct: 94 NFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLA 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KKFRD ++ KHIPYRENKNLTGTARYAS+NTHLG+EQSRRDDLESLGYVLMYF G+LPW Sbjct: 154 KKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA K+QKY++ISEKK+ T + VLCK +PSEF++Y ++CR + F+ +PDY +L++LF Sbjct: 214 QGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 R+LF R G+ +DYVFDW Sbjct: 274 RNLFHRLGFTYDYVFDW 290
>KC1_PLAF4 (O15726) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 309 bits (791), Expect = 5e-84 Identities = 138/195 (70%), Positives = 171/195 (87%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+RKFSLKTV M ADQM+NR+EY+H K F+HRDIKPDNFL+G G+K ++IID+GLAKK Sbjct: 96 CNRKFSLKTVRMTADQMLNRIEYVHSKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKK 155 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +RD ++H PY+E KNLTGTARYAS+NTHLG+EQSRRDD+E+LGYVLMYFLRGSLPWQG Sbjct: 156 YRDSRSHTSYPYKEGKNLTGTARYASINTHLGIEQSRRDDIEALGYVLMYFLRGSLPWQG 215 Query: 368 LKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 LKA +KK KYDKI EKK+ T VEVLC++ EF++Y +YCRSLRFED+PDY+YL+RL +D Sbjct: 216 LKAISKKDKYDKIMEKKISTSVEVLCRNASFEFVTYLNYCRSLRFEDRPDYTYLRRLLKD 275 Query: 548 LFIREGYQFDYVFDW 592 LFIREG+ +D++FDW Sbjct: 276 LFIREGFTYDFLFDW 290
>KC1AL_HUMAN (Q8N752) Casein kinase I isoform alpha-like (EC 2.7.11.1)| (CKI-alpha-like) (CK1) Length = 337 Score = 308 bits (789), Expect = 8e-84 Identities = 140/197 (71%), Positives = 169/197 (85%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K FLHRDIKPDNFLMG GR N++++ID+GLA Sbjct: 102 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIPYRE+K+L GT RYAS+N HLG+EQSRRDD+ESLGYV MYF R SLPW Sbjct: 162 KKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM TPVEVLCK +P+EF Y +YCR LRFE+ PDY YL++LF Sbjct: 222 QGLKAMTKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 282 RILFRTLNHQYDYTFDW 298
>YKL1_CAEEL (P42168) Putative casein kinase I C03C10.1 in chromosome III (EC| 2.7.11.1) Length = 341 Score = 306 bits (785), Expect = 2e-83 Identities = 139/197 (70%), Positives = 168/197 (85%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 101 NFCSRRFTMKTVLMLADQMIGRIEYVHVKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 160 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T HIPYRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYVLMYF RG+LPW Sbjct: 161 KKYRDSRTRTHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRGTLPW 220 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKY+KISEKKM T VE LCK +P+EF Y Y R LRF++ PDY YL++LF Sbjct: 221 QGLKAATKKQKYEKISEKKMTTSVEHLCKGFPAEFPMYLSYTRGLRFDESPDYMYLRQLF 280 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY FDW Sbjct: 281 RILFRTLNHQYDYTFDW 297
>KC1A_DROME (P54367) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (DmCK1) Length = 337 Score = 305 bits (780), Expect = 9e-83 Identities = 137/197 (69%), Positives = 169/197 (85%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+C+R F++KTVLML DQMI R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 105 NFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 164 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KKFRD T HI YRE+KNLTGTARYAS+N HLG+EQSRRDD+ESLGYV+MYF RG LPW Sbjct: 165 KKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPW 224 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QG+KA TK+QKY+KISEKKM TP+EVLCK P+EF Y +YCRSLRFE++PDY YL++LF Sbjct: 225 QGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLF 284 Query: 542 RDLFIREGYQFDYVFDW 592 R LF +Q+DY++DW Sbjct: 285 RILFRTLNHQYDYIYDW 301
>HHP2_SCHPO (P40236) Casein kinase I homolog hhp2 (EC 2.7.11.1)| Length = 400 Score = 301 bits (772), Expect = 7e-82 Identities = 138/196 (70%), Positives = 169/196 (86%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK 184 YC RKF+LKTVL+LADQ+I+R+EY+H K FLHRDIKPDNFLM + +N V +ID+GLAK Sbjct: 98 YCGRKFTLKTVLLLADQLISRIEYVHSKSFLHRDIKPDNFLMK--KHSNVVTMIDFGLAK 155 Query: 185 KFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 K+RD +TH HIPYR+NKNLTGTARYAS+NTH+G+EQSRRDDLESLGYVL+YF RGSLPWQ Sbjct: 156 KYRDFKTHVHIPYRDNKNLTGTARYASINTHIGIEQSRRDDLESLGYVLLYFCRGSLPWQ 215 Query: 365 GLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFR 544 GL+A TK+QKY +I + K+ TP+EVLCK P EFI+Y Y R L F +KP+Y+YL++LFR Sbjct: 216 GLQADTKEQKYQRIRDTKIGTPLEVLCKGLPEEFITYMCYTRQLSFTEKPNYAYLRKLFR 275 Query: 545 DLFIREGYQFDYVFDW 592 DL IR+GYQ+DYVFDW Sbjct: 276 DLLIRKGYQYDYVFDW 291
>KIN20_CAEEL (Q20471) Casein kinase I isoform delta (EC 2.7.11.1) (Protein| kinase 20) Length = 497 Score = 296 bits (757), Expect = 4e-80 Identities = 136/197 (69%), Positives = 167/197 (84%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+C RKFSLKTVL+LADQM++RVE++H + ++HRDIKPDNFLMGLG++ N VYIID+GLA Sbjct: 276 NFCQRKFSLKTVLLLADQMLSRVEFIHCRDYIHRDIKPDNFLMGLGKRGNLVYIIDFGLA 335 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++RD + H+HI YRENKNLTGTARYAS+NTH G+EQSRRDD+ESLGYV MYF RG+LPW Sbjct: 336 KRYRDSK-HQHIAYRENKNLTGTARYASINTHRGIEQSRRDDIESLGYVFMYFNRGTLPW 394 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TK+QKY+ ISEKK+ T V+ LC YP F Y +YCRSL FE++PDY YL+ LF Sbjct: 395 QGLKAVTKRQKYELISEKKISTRVDDLCAGYPEAFAQYLNYCRSLGFEEQPDYGYLRNLF 454 Query: 542 RDLFIREGYQFDYVFDW 592 R LF R+ + +DYVFDW Sbjct: 455 RTLFHRQQFCYDYVFDW 471
>HRR25_YEAST (P29295) Casein kinase I homolog HRR25 (EC 2.7.11.1)| Length = 494 Score = 293 bits (750), Expect = 3e-79 Identities = 132/197 (67%), Positives = 164/197 (83%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 NYC R+FS KTV+MLA QM R++Y+H + F+HRDIKPDNFLMG+GR+ + V++ID+GL+ Sbjct: 94 NYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLS 153 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD TH+HIPYRENK+LTGTARYASVNTHLG+EQSRRDDLESLGYVL+YF +GSLPW Sbjct: 154 KKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPW 213 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA TKKQKYD+I EKK+ VE LC P EF Y YC++L+F++KPDY +L RLF Sbjct: 214 QGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLF 273 Query: 542 RDLFIREGYQFDYVFDW 592 +DL I+ Y D++FDW Sbjct: 274 KDLSIKLEYHNDHLFDW 290
>KC1B_BOVIN (P35507) Casein kinase I isoform beta (EC 2.7.11.1) (CKI-beta)| Length = 336 Score = 274 bits (701), Expect = 1e-73 Identities = 125/197 (63%), Positives = 157/197 (79%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+FS+KTVLMLADQMI+R+EY+H + +HRDIKPDNFLMG G + +++++D+GLA Sbjct: 102 NFCSRRFSMKTVLMLADQMISRIEYVHSRNLIHRDIKPDNFLMGTGPQWKKLFLVDFGLA 161 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 KK+RD +T +HIP+R K+ GT AS++ HLG+EQSRRDD+ES+GYVLMYF RGSLPW Sbjct: 162 KKYRDNRTGQHIPHRSGKSFIGTPFCASISAHLGIEQSRRDDMESIGYVLMYFNRGSLPW 221 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T KQK +KISE KM TPV+VLCK +P EF Y YC L FE+ PDY YL++LF Sbjct: 222 QGLKAATLKQKCEKISEMKMTTPVDVLCKGFPIEFAMYLKYCLRLSFEEAPDYRYLRQLF 281 Query: 542 RDLFIREGYQFDYVFDW 592 R LF + YQ DY FDW Sbjct: 282 RLLFRKLSYQHDYAFDW 298
>KC1G3_RAT (Q62763) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 448 Score = 268 bits (684), Expect = 1e-71 Identities = 125/197 (63%), Positives = 159/197 (80%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL-GRKANQV-YIIDYGLA 181 C R FSLKTVLM+A Q+I+R+EY+H K ++RD+KP+NFL+G G KA QV +IID+GLA Sbjct: 130 CDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKAQQVIHIIDFGLA 189 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 190 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 249 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+EVLC+++P E +Y Y R L F +KPDY YL++LF Sbjct: 250 QGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLF 309 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R+GY FDY +DW Sbjct: 310 TDLFDRKGYMFDYEYDW 326
>KC1G2_RAT (Q62762) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 263 bits (673), Expect = 2e-70 Identities = 120/197 (60%), Positives = 156/197 (79%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGLA 181 C R F+LKTVLM+A Q+I R+EY+H K ++RD+KP+NFL+G ++ + ++IID+GLA Sbjct: 133 CDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLA 192 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 193 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 252 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+EVLC+S+P E +Y Y R L F +KPDY YL++LF Sbjct: 253 QGLKADTLKERYQKIGDTKRATPIEVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLF 312 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R GY FDY +DW Sbjct: 313 TDLFDRSGYVFDYEYDW 329
>KC1G2_MOUSE (Q8BVP5) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 263 bits (673), Expect = 2e-70 Identities = 120/197 (60%), Positives = 156/197 (79%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGLA 181 C R F+LKTVLM+A Q+I R+EY+H K ++RD+KP+NFL+G ++ + ++IID+GLA Sbjct: 133 CDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLA 192 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 193 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 252 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+EVLC+S+P E +Y Y R L F +KPDY YL++LF Sbjct: 253 QGLKADTLKERYQKIGDTKRATPIEVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLF 312 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R GY FDY +DW Sbjct: 313 TDLFDRSGYVFDYEYDW 329
>KC1G1_RAT (Q62761) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 390 Score = 262 bits (670), Expect = 5e-70 Identities = 118/197 (59%), Positives = 157/197 (79%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGLA 181 C R F+LKTVLM+A Q+++R+EY+H K ++RD+KP+NFL+G +K + ++IID+GLA Sbjct: 132 CDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLA 191 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 192 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 251 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+E LC+++P E ++Y Y R L F +KPDY YL+ LF Sbjct: 252 QGLKADTLKERYQKIGDTKRSTPIEALCENFPEEMMTYLRYVRRLDFFEKPDYEYLRNLF 311 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R+GY FDY +DW Sbjct: 312 TDLFERKGYTFDYAYDW 328
>KC1G3_HUMAN (Q9Y6M4) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 447 Score = 261 bits (668), Expect = 8e-70 Identities = 124/197 (62%), Positives = 158/197 (80%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL-GRKANQV-YIIDYGLA 181 C R FSLKTVLM+A Q+I+R+EY+H K ++RD+KP+NFL+G G K QV +IID+GLA Sbjct: 130 CDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLA 189 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 190 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 249 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+EVLC+++P E +Y Y R L F +KPDY YL++LF Sbjct: 250 QGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLF 308 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R+GY FDY +DW Sbjct: 309 TDLFDRKGYMFDYEYDW 325
>KC1G1_MOUSE (Q8BTH8) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 459 Score = 261 bits (666), Expect = 1e-69 Identities = 118/197 (59%), Positives = 156/197 (79%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGLA 181 C R F+LKTVLM+A Q+++R+EY+H K ++RD+KP+NFL+G +K + ++IID+GLA Sbjct: 132 CDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLA 191 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 192 KEYVDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 251 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+E LC+++P E +Y Y R L F +KPDY YL+ LF Sbjct: 252 QGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLF 311 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R+GY FDY +DW Sbjct: 312 TDLFERKGYTFDYAYDW 328
>KC1G1_HUMAN (Q9HCP0) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 422 Score = 259 bits (663), Expect = 3e-69 Identities = 117/197 (59%), Positives = 156/197 (79%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGLA 181 C R F+LKTVLM+A Q+++R+EY+H K ++RD+KP+NFL+G +K + ++IID+GLA Sbjct: 132 CDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLA 191 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 192 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 251 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+E LC+++P E +Y Y R L F +KPDY YL+ LF Sbjct: 252 QGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLF 311 Query: 542 RDLFIREGYQFDYVFDW 592 DLF ++GY FDY +DW Sbjct: 312 TDLFEKKGYTFDYAYDW 328
>KC1G2_HUMAN (P78368) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 259 bits (663), Expect = 3e-69 Identities = 118/197 (59%), Positives = 156/197 (79%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLG--RKANQVYIIDYGLA 181 C R F+LKTVLM+A Q+I R+EY+H K ++RD+KP+NFL+G ++ + ++IID+GLA Sbjct: 133 CDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLA 192 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 193 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 252 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T K++Y KI + K TP+EVLC+++P E +Y Y R L F +KPDY YL++LF Sbjct: 253 QGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLF 312 Query: 542 RDLFIREGYQFDYVFDW 592 DLF R G+ FDY +DW Sbjct: 313 TDLFDRSGFVFDYEYDW 329
>CKI3_SCHPO (O74135) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 439 Score = 253 bits (645), Expect = 4e-67 Identities = 115/199 (57%), Positives = 152/199 (76%), Gaps = 2/199 (1%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYG 175 +YC R+FS KTV M+A QMI R++ +H++ F++RDIKPDNFL+G + N +Y +D+G Sbjct: 100 DYCGRRFSPKTVAMIAKQMITRIQSVHERHFIYRDIKPDNFLIGFPGSKTENVIYAVDFG 159 Query: 176 LAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 +AK++RD +TH H PY E+K+L+GTARY S+NTHLG EQSRRDDLES+G+V MYFLRGSL Sbjct: 160 MAKQYRDPKTHVHRPYNEHKSLSGTARYMSINTHLGREQSRRDDLESMGHVFMYFLRGSL 219 Query: 356 PWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKR 535 PWQGLKA T KQKY+KI EKK +TP++ LC+ YP EF+ Y Y R+L +E+ PDY YL+ Sbjct: 220 PWQGLKAATNKQKYEKIGEKKQVTPLKELCEGYPKEFLQYMIYARNLGYEEAPDYDYLRS 279 Query: 536 LFRDLFIREGYQFDYVFDW 592 LF L +R D +DW Sbjct: 280 LFDSLLLRINETDDGKYDW 298
>CKI2_SCHPO (P40234) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 435 Score = 248 bits (633), Expect = 9e-66 Identities = 116/198 (58%), Positives = 150/198 (75%), Gaps = 2/198 (1%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGL 178 +C R+FS+KTV M A QM++RV+ +H+K ++RDIKPDNFL+G R AN VY++D+G+ Sbjct: 98 WCGRRFSVKTVAMTAKQMLSRVQTIHEKNLVYRDIKPDNFLIGRPSSRNANMVYMVDFGM 157 Query: 179 AKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLP 358 AK +RD +T +HIPY E K+L+GTARY S+NTHLG EQSRRDDLESLG+V MYFLRGSLP Sbjct: 158 AKYYRDPKTKQHIPYSERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGSLP 217 Query: 359 WQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 WQGLKA K KY+KISEKK T + LC +P+EF Y Y RSL F+++PDY++L+ L Sbjct: 218 WQGLKAANNKHKYEKISEKKQSTSISELCAGFPNEFSKYMTYVRSLEFDEEPDYAFLQEL 277 Query: 539 FRDLFIREGYQFDYVFDW 592 F D+ G D V+DW Sbjct: 278 FDDVLRANGDTNDGVYDW 295
>CKI1_SCHPO (P40233) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 446 Score = 246 bits (629), Expect = 3e-65 Identities = 116/197 (58%), Positives = 144/197 (73%), Gaps = 2/197 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKANQVYIIDYGLA 181 C RKFS+KTV M A QM+ RV+ +H+K ++RDIKPDNFL+G + AN +Y++D+G+ Sbjct: 99 CGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMV 158 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K +RD T +HIPYRE KNL+GTARY S+NTHLG EQSRRDDLE+LG+V MYFLRGSLPW Sbjct: 159 KFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPW 218 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 QGLKA T KQKY++I EKK TP+ LC +P EF Y HY R+L F+ PDY YL+ LF Sbjct: 219 QGLKAATNKQKYERIGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLF 278 Query: 542 RDLFIREGYQFDYVFDW 592 + R D FDW Sbjct: 279 SKVLERLNTTEDENFDW 295
>KC12_YEAST (P23292) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 546 Score = 213 bits (541), Expect = 4e-55 Identities = 104/199 (52%), Positives = 140/199 (70%), Gaps = 2/199 (1%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRK--ANQVYIIDYG 175 ++C R+FS+KTV+ +A QMI +E +H ++RDIKPDNFL+G + AN+V++ID+G Sbjct: 161 DWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFG 220 Query: 176 LAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 +AK++RD +T +HIPYRE K+L+GTARY S+NTHLG EQSRRDD+E++G+V YFLRG L Sbjct: 221 MAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQL 280 Query: 356 PWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKR 535 PWQGLKA KQKY+KI EKK LT V L + P +F Y R+L FE+ PDY + Sbjct: 281 PWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYLEIVRNLSFEETPDYEGYRM 340 Query: 536 LFRDLFIREGYQFDYVFDW 592 L + G D +DW Sbjct: 341 LLLSVLDDLGETADGQYDW 359
>KC11_YEAST (P23291) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 538 Score = 213 bits (541), Expect = 4e-55 Identities = 105/199 (52%), Positives = 139/199 (69%), Gaps = 2/199 (1%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRK--ANQVYIIDYG 175 ++C RKFS+KTV+ +A QMI +E +H ++RDIKPDNFL+G + AN +++ID+G Sbjct: 154 DWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFG 213 Query: 176 LAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 +AK++RD +T +HIPYRE K+L+GTARY S+NTHLG EQSRRDD+E+LG+V YFLRG L Sbjct: 214 MAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHL 273 Query: 356 PWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKR 535 PWQGLKA KQKY+KI EKK T V L + P +F Y RSL FE+ PDY ++ Sbjct: 274 PWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRK 333 Query: 536 LFRDLFIREGYQFDYVFDW 592 L + G D +DW Sbjct: 334 LLLSVLDDLGETADGQYDW 352
>KC1G3_BOVIN (P35509) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) (Fragment) Length = 276 Score = 212 bits (540), Expect = 6e-55 Identities = 102/161 (63%), Positives = 131/161 (81%), Gaps = 2/161 (1%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL-GRKANQV-YIIDYGLA 181 C R FSLKTVLM+A Q+I+R+EY+H K ++RD+KP+NFL+G G K QV +IID+GLA Sbjct: 116 CDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLA 175 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K++ D +T KHIPYRE+K+LTGTARY S+NTHLG EQSRRDDLE+LG++ MYFLRGSLPW Sbjct: 176 KEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 235 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHY 484 QGLKA T K++Y KI + K TP+EVLC+++P E +Y Y Sbjct: 236 QGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRY 275
>RAG8_KLULA (P40230) Casein kinase I homolog RAG8 (EC 2.7.11.1)| Length = 536 Score = 212 bits (539), Expect = 8e-55 Identities = 103/199 (51%), Positives = 138/199 (69%), Gaps = 2/199 (1%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRK--ANQVYIIDYG 175 ++C R+FS+KTV+ +A QMI +E +H ++RDIKPDNFL+G + AN V++ID+G Sbjct: 162 DWCGRRFSIKTVVHVAIQMITLIEELHDHDLIYRDIKPDNFLIGRPNQPDANMVHLIDFG 221 Query: 176 LAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 +AK +RD +T +HIPYRE K+L+GTARY S+NTHLG EQSRRDD+E+LG+V YFLRG L Sbjct: 222 MAKLYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGQL 281 Query: 356 PWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKR 535 PWQGLKA K KY+KI EKK T V L + P +F Y R+L FE+ PDY ++ Sbjct: 282 PWQGLKAANNKLKYEKIGEKKRSTNVYDLSQGLPVQFGRYLEIVRNLGFEETPDYEGYRK 341 Query: 536 LFRDLFIREGYQFDYVFDW 592 L + G + D +DW Sbjct: 342 LLLSVLDELGQKLDGEYDW 360
>KC13_YEAST (P39962) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 524 Score = 205 bits (521), Expect = 9e-53 Identities = 105/216 (48%), Positives = 140/216 (64%), Gaps = 20/216 (9%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKA------------ 148 +C RKFS+KT M+A QMI+RV +H ++RDIKPDNFL+ ++ Sbjct: 117 WCGRKFSVKTTCMVAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCAS 176 Query: 149 ------NQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDL 310 N +Y++D+G+AK++RD +T +HIPYRE K+L+GTARY S+NTH G EQSRRDDL Sbjct: 177 SSNNDPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSLSGTARYMSINTHFGREQSRRDDL 236 Query: 311 ESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKIS-EKKMLTPVEVLC-KSYPSEFISYFHY 484 ESLG+V YFLRGSLPWQGLKA K KY+KI K+ L P ++L + P +F +Y Y Sbjct: 237 ESLGHVFFYFLRGSLPWQGLKAPNNKLKYEKIGMTKQKLNPDDLLLNNAIPYQFATYLKY 296 Query: 485 CRSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDW 592 RSL+F++ PDY YL L D + D +DW Sbjct: 297 ARSLKFDEDPDYDYLISLMDDALRLNDLKDDGHYDW 332
>KC1D_RABIT (P81123) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) (Fragment) Length = 81 Score = 145 bits (366), Expect = 9e-35 Identities = 67/78 (85%), Positives = 74/78 (94%) Frame = +2 Query: 107 IKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGV 286 I PDNFLMGLG+K N VYIID+GLAKK+RD +TH+HIPYRENKNLTGTARYAS+NTHLG+ Sbjct: 2 IFPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI 61 Query: 287 EQSRRDDLESLGYVLMYF 340 EQSRRDDLESLGYVLMYF Sbjct: 62 EQSRRDDLESLGYVLMYF 79
>TTBK1_HUMAN (Q5TCY1) Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau| kinase) Length = 1321 Score = 125 bits (313), Expect = 1e-28 Identities = 75/196 (38%), Positives = 102/196 (52%), Gaps = 5/196 (2%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMG-LGRKANQVYIIDYGLAKKFRD 196 F+L T L L Q++ +E +H GFLHRDIKP NF MG L + Y++D+GLA+++ + Sbjct: 126 FTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTN 185 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK- 373 T P R GT RYASVN H E R DDL SL Y+L+ F G LPW+ +K Sbjct: 186 T-TGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKD 244 Query: 374 ---AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFR 544 G K+KY+ +L K PSEF + + SL + KPDY + +F Sbjct: 245 KEQVGMIKEKYEH----------RMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFE 294 Query: 545 DLFIREGYQFDYVFDW 592 + G + FDW Sbjct: 295 NSMKERGIAENEAFDW 310
>TTBK2_MOUSE (Q3UVR3) Tau-tubulin kinase 2| Length = 1243 Score = 117 bits (293), Expect = 3e-26 Identities = 70/196 (35%), Positives = 101/196 (51%), Gaps = 5/196 (2%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMG-LGRKANQVYIIDYGLAKKFRD 196 F++ T L L Q++ +E +H GFLHRDIKP NF MG + +++D+GLA++F + Sbjct: 113 FTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTN 172 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK- 373 P R GT RYAS+N H E R DDL SL Y+L+ F+ G LPW+ +K Sbjct: 173 SCGDVRPP-RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKD 231 Query: 374 ---AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFR 544 G+ K++YD ++ K P EF ++ + SL + KPDY L +F Sbjct: 232 KEQVGSIKERYDH----------RLMLKHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFD 281 Query: 545 DLFIREGYQFDYVFDW 592 + G FDW Sbjct: 282 NSIKTFGVIESDPFDW 297
>TTBK2_HUMAN (Q6IQ55) Tau-tubulin kinase 2 (EC 2.7.11.1)| Length = 1244 Score = 117 bits (293), Expect = 3e-26 Identities = 71/196 (36%), Positives = 100/196 (51%), Gaps = 5/196 (2%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMG-LGRKANQVYIIDYGLAKKFRD 196 F++ T L L Q++ +E +H GFLHRDIKP NF MG + Y++D+GLA++F + Sbjct: 113 FTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTN 172 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK- 373 P R GT RYAS+N H E R DDL SL Y+L+ F+ G LPW+ +K Sbjct: 173 SCGDVRPP-RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKD 231 Query: 374 ---AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFR 544 G+ K++YD ++ K P EF + + SL + KPDY L +F Sbjct: 232 KEQVGSIKERYDH----------RLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFD 281 Query: 545 DLFIREGYQFDYVFDW 592 + G FDW Sbjct: 282 NSIKTFGVIESDPFDW 297
>VRK1_HUMAN (Q99986) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 396 Score = 107 bits (266), Expect = 3e-23 Identities = 59/177 (33%), Positives = 97/177 (54%), Gaps = 3/177 (1%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 +++FS KTVL L+ ++++ +EY+H+ ++H DIK N L+ + +QVY++DYGLA ++ Sbjct: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRY 204 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 HK + GT + S++ H GV SRR DLE LGY ++ +L G LPW+ Sbjct: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 Query: 371 KAGTKKQKYDKISEKKMLTPVEVLC---KSYPSEFISYFHYCRSLRFEDKPDYSYLK 532 K + KI ++ + + C K+ P E Y + L + +KP Y L+ Sbjct: 265 LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR 321
>KC1A_PIG (O19175) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) (Fragment) Length = 125 Score = 106 bits (264), Expect = 6e-23 Identities = 44/63 (69%), Positives = 59/63 (93%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 N+CSR+F++KTVLMLADQMI+R+EY+H K F+HRDIKPDNFLMG+GR N++++ID+GLA Sbjct: 63 NFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 122 Query: 182 KKF 190 KK+ Sbjct: 123 KKY 125
>VRK1_MOUSE (Q80X41) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK) Length = 440 Score = 104 bits (260), Expect = 2e-22 Identities = 58/177 (32%), Positives = 95/177 (53%), Gaps = 3/177 (1%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 +++FS KTVL L+ ++++ +EY+H+ ++H DIK N L+ + +QVY++DYGLA ++ Sbjct: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLS-HKNPDQVYLVDYGLAYRY 204 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 HK + GT + S++ H GV SRR DLE LGY ++ +L G LPW+ Sbjct: 205 CPDGVHKEYKEDPKRCHDGTLEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGCLPWEDN 264 Query: 371 KAGTKKQKYDKISEKKMLTPVEVLC---KSYPSEFISYFHYCRSLRFEDKPDYSYLK 532 + KI + + + C K+ P E Y + L + +KP Y L+ Sbjct: 265 LKDPNYVRDSKIRYRDNVAALMEKCFPEKNKPGEIAKYMESVKLLEYTEKPLYQNLR 321
>VRK2_MOUSE (Q8BN21) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 503 Score = 103 bits (258), Expect = 3e-22 Identities = 60/180 (33%), Positives = 93/180 (51%), Gaps = 7/180 (3%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F TVL L +M++ +EY+H+ ++H DIK N L+ ++VY+ DYGL+ ++ Sbjct: 138 FKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF-TNPDRVYLADYGLSYRYCPN 196 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---- 367 HK K GT + S++ H GV SRR D+E LGY ++++L G LPW+ Sbjct: 197 GNHKQYQEDPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDD 256 Query: 368 --LKAGTKKQKYDKISEKKM-LTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 K D++ E + P C SE + Y Y +L ++DKPDY LK++ Sbjct: 257 PVAVQTAKTNLLDELPESVLKWAPSGSSC----SELVKYLMYVHNLAYDDKPDYQKLKKI 312
>VPK1_VACCV (P16913) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 100 bits (249), Expect = 3e-21 Identities = 53/179 (29%), Positives = 98/179 (54%), Gaps = 9/179 (5%) Frame = +2 Query: 29 KTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTH 208 ++V+++ +++N +++MH++G+ H DIK N ++ K N++Y++DYGL KF + Sbjct: 122 RSVMLIGIEILNTIQFMHEQGYSHGDIKASNIVLDQIDK-NKLYLVDYGLVSKF--MSNG 178 Query: 209 KHIPYRENKNL--TGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK--- 373 +H+P+ N N GT + +++H G SRR DLE+LGY ++ +L G LPW + Sbjct: 179 EHVPFIRNPNKMDNGTLEFTPIDSHKGYVVSRRGDLETLGYCMIRWLGGILPWTKISETK 238 Query: 374 ----AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 KQKY + ++T ++ P E + Y SL + ++P+Y + + Sbjct: 239 NCALVSATKQKYVNNTATLLMTSLQYA----PRELLQYITMVNSLTYFEEPNYDEFRHI 293
>VPK1_VACCC (P20505) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 100 bits (249), Expect = 3e-21 Identities = 53/179 (29%), Positives = 98/179 (54%), Gaps = 9/179 (5%) Frame = +2 Query: 29 KTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTH 208 ++V+++ +++N +++MH++G+ H DIK N ++ K N++Y++DYGL KF + Sbjct: 122 RSVMLIGIEILNTIQFMHEQGYSHGDIKASNIVLDQIDK-NKLYLVDYGLVSKF--MSNG 178 Query: 209 KHIPYRENKNL--TGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK--- 373 +H+P+ N N GT + +++H G SRR DLE+LGY ++ +L G LPW + Sbjct: 179 EHVPFIRNPNKMDNGTLEFTPIDSHKGYVVSRRGDLETLGYCMIRWLGGILPWTKISETK 238 Query: 374 ----AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 KQKY + ++T ++ P E + Y SL + ++P+Y + + Sbjct: 239 NCALVSATKQKYVNNTATLLMTSLQYA----PRELLQYITMVNSLTYFEEPNYDEFRHI 293
>VPK1_VACCA (O57252) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 100 bits (249), Expect = 3e-21 Identities = 53/179 (29%), Positives = 98/179 (54%), Gaps = 9/179 (5%) Frame = +2 Query: 29 KTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTH 208 ++V+++ +++N +++MH++G+ H DIK N ++ K N++Y++DYGL KF + Sbjct: 122 RSVMLIGIEILNTIQFMHEQGYSHGDIKASNIVLDQIDK-NKLYLVDYGLVSKF--MSNG 178 Query: 209 KHIPYRENKNL--TGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK--- 373 +H+P+ N N GT + +++H G SRR DLE+LGY ++ +L G LPW + Sbjct: 179 EHVPFIRNPNKMDNGTLEFTPIDSHKGYVVSRRGDLETLGYCMIRWLGGILPWTKISETK 238 Query: 374 ----AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 KQKY + ++T ++ P E + Y SL + ++P+Y + + Sbjct: 239 NCALVSATKQKYVNNTATLLMTSLQYA----PRELLQYITMVNSLTYFEEPNYDKFRHI 293
>VRK2_HUMAN (Q86Y07) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 508 Score = 100 bits (248), Expect = 4e-21 Identities = 64/181 (35%), Positives = 96/181 (53%), Gaps = 8/181 (4%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F TVL L +M++ +EY+H+ ++H DIK N L+G + +QVY+ DYGL+ ++ Sbjct: 138 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPN 196 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW-QGLK- 373 HK K GT + S++ H GV SRR D+E LGY ++ +L G LPW Q LK Sbjct: 197 GNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKD 256 Query: 374 -AGTKKQKYDKISEKKMLTPVEVLCKSYPS-----EFISYFHYCRSLRFEDKPDYSYLKR 535 + K + + E P VL K PS E + SL +++KP+Y LK+ Sbjct: 257 PVAVQTAKTNLLDE----LPQSVL-KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKK 311 Query: 536 L 538 + Sbjct: 312 I 312
>VPK1_VARV (P33800) Serine/threonine-protein kinase 1 (EC 2.7.11.1)| Length = 300 Score = 98.6 bits (244), Expect = 1e-20 Identities = 55/180 (30%), Positives = 101/180 (56%), Gaps = 10/180 (5%) Frame = +2 Query: 29 KTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTH 208 ++V+++ +++N +++MH++G+ H +IK N ++ K N++Y++DYGL KF + Sbjct: 122 RSVMLVGIEILNTIQFMHEQGYSHGNIKASNIVLDQMDK-NKLYLVDYGLVSKF--MSNG 178 Query: 209 KHIPYRENKNL--TGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGT 382 +H+P+ N N GT + +++H G SRR DLE+LGY ++ +L G LPW + A T Sbjct: 179 EHVPFIRNPNKMDNGTLEFTPIDSHKGYVVSRRGDLETLGYCMIRWLGGILPWTKI-AET 237 Query: 383 K--------KQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 K KQKY + ++T ++ P E + Y SL + ++P+Y + + Sbjct: 238 KNCALVSATKQKYVNNTTTLLMTSLQYA----PRELLQYITMVNSLTYFEEPNYDKFRHI 293
>V212_FOWPV (Q9J523) Probable serine/threonine-protein kinase FPV212 (EC| 2.7.11.1) Length = 303 Score = 98.2 bits (243), Expect = 2e-20 Identities = 58/181 (32%), Positives = 95/181 (52%), Gaps = 6/181 (3%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF++ + LA ++++ ++++H K F H DIK N L G + ++VY++DYGLA K+ Sbjct: 131 KFNITVIKKLAIKILDILKFIHSKEFSHGDIKAGNILFG--KDDDKVYLVDYGLATKYSS 188 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK- 373 HK GT + S++ H GV SRR DLESLG+ ++ + G LPW+ + Sbjct: 189 NGKHKEYTINPKNRHNGTMAFTSIDAHKGVTVSRRGDLESLGFCMLKWYSGKLPWEKYEK 248 Query: 374 -----AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRL 538 G K+ + IS+K + P + Y +Y L +E+ P+Y LK++ Sbjct: 249 EPENVQGMKEAFVNNISKKTI--PFKNAGIIY-----NYIKVVTKLEYEEAPNYESLKQM 301 Query: 539 F 541 F Sbjct: 302 F 302
>VRK1_BRARE (Q7ZUS1) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 425 Score = 93.2 bits (230), Expect = 5e-19 Identities = 55/183 (30%), Positives = 93/183 (50%), Gaps = 6/183 (3%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 +KFS K VL L ++++ +EY+H ++H DIK N L+ NQV+++DYGLA ++ Sbjct: 148 KKFSRKLVLQLGLRLLDILEYIHDHEYVHADIKASNLLLSY-TNPNQVFLVDYGLAYRYA 206 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK 373 K + GT + S++ H GV SRR DLE +GY ++ +L LPW+ Sbjct: 207 PEGVPKEYKEDPKRCHDGTIEFTSIDAHKGVSPSRRADLEIMGYCMIQWLCSRLPWED-- 264 Query: 374 AGTKKQKYDKISEKKMLTPVEVLCKS------YPSEFISYFHYCRSLRFEDKPDYSYLKR 535 + Y + S+ + ++ KS P+E + + L + D+PDY L+ Sbjct: 265 -KLQDPLYVRDSKLRCRDNIDEFLKSCFASGNIPAEMGKFMQEVKVLGYTDRPDYDKLRG 323 Query: 536 LFR 544 + + Sbjct: 324 ILQ 326
>V226_FOWPV (Q9J509) Probable serine/threonine-protein kinase FPV226 (EC| 2.7.11.1) Length = 292 Score = 89.4 bits (220), Expect = 7e-18 Identities = 59/167 (35%), Positives = 86/167 (51%), Gaps = 2/167 (1%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPY-REN 232 M+ +EY+H+ G H DIKP+N ++ GR + Y+IDYG+ F + KH+ Y +E+ Sbjct: 131 MLYTLEYIHEHGISHGDIKPENIMVD-GRYRS--YLIDYGIVSYF--IVNGKHVKYYKES 185 Query: 233 KNL-TGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKIS 409 KN GT YAS++ H G +RR DLESLGY ++ + LPW+ K Sbjct: 186 KNWHRGTLYYASLDAHNGTCVTRRGDLESLGYCMLKWAGIPLPWKVFGNNGNMVHVAKCD 245 Query: 410 EKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDL 550 K + +V KS Y L +E+KPDY L++L L Sbjct: 246 FIKRVHKNKVNIKSANKGIYDYIKCVTKLSYEEKPDYDLLRQLVNSL 292
>KRB2_VACCC (P21098) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 88.6 bits (218), Expect = 1e-17 Identities = 55/168 (32%), Positives = 84/168 (50%), Gaps = 6/168 (3%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 MIN +E++H +GF H I+P N L+ + ++ +IDY K + HI Y E+ Sbjct: 123 MINTLEFIHSRGFTHGKIEPRNILI----RNKRLSLIDYSRTNKLYK-SGNSHIDYNEDM 177 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ---GLKAGTKKQKYDKI 406 +G Y V+ HLG SRR DLE LGY ++ + G LPW+ +K +K++Y Sbjct: 178 ITSGNINYMCVDNHLGATVSRRGDLEMLGYCMIEWFGGKLPWKNESSIKVIKQKKEY--- 234 Query: 407 SEKKMLTPVEVLC---KSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 KK + C + P E + Y +L + P+Y L+RLF Sbjct: 235 --KKFIATFFEDCFPEGNEPLELVRYIELVYTLDYSQTPNYDRLRRLF 280
>KRB2_VACCA (O57259) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 87.4 bits (215), Expect = 3e-17 Identities = 54/168 (32%), Positives = 84/168 (50%), Gaps = 6/168 (3%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 MIN +E++H +GF H I+P N L+ + ++ +IDY K + HI Y E+ Sbjct: 123 MINTLEFIHSRGFTHGKIEPRNILI----RNKRLSLIDYSRTNKLYK-SGNSHIDYNEDM 177 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ---GLKAGTKKQKYDKI 406 +G Y V+ HLG S+R DLE LGY ++ + G LPW+ +K +K++Y Sbjct: 178 ITSGNINYMCVDNHLGATVSKRGDLEMLGYCMIEWFGGKLPWKNESSIKVIKQKKEY--- 234 Query: 407 SEKKMLTPVEVLC---KSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 KK + C + P E + Y +L + P+Y L+RLF Sbjct: 235 --KKFIATFFEDCFPEGNEPLELVRYIELVYTLDYSQTPNYDRLRRLF 280
>KRB2_VACCV (P24362) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 87.0 bits (214), Expect = 4e-17 Identities = 54/168 (32%), Positives = 84/168 (50%), Gaps = 6/168 (3%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 MIN +E++H +GF H I+P N L+ + ++ +IDY K + HI Y E+ Sbjct: 123 MINTLEFIHSQGFTHGKIEPRNILI----RNKRLSLIDYSRTNKLYK-SGNSHIDYNEDM 177 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ---GLKAGTKKQKYDKI 406 +G Y V+ HLG SRR DLE LGY ++ + G LPW+ +K +K++Y Sbjct: 178 ITSGNINYMCVDNHLGATVSRRGDLEMLGYCMIEWFGGKLPWKNESSIKVIKQKKEY--- 234 Query: 407 SEKKMLTPVEVLC---KSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 KK + C + P E + Y +L + P+Y L++LF Sbjct: 235 --KKFIATFFEDCFPEGNEPLELVRYIELVYTLDYSQTPNYDRLRKLF 280
>NHK1_DROME (Q7KRY6) Nucleosomal histone kinase 1 (EC 2.7.11.1) (Protein| baellchen) Length = 599 Score = 85.9 bits (211), Expect = 8e-17 Identities = 64/175 (36%), Positives = 82/175 (46%), Gaps = 5/175 (2%) Frame = +2 Query: 32 TVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGR-KANQVYIIDYGLAKKFRDLQTH 208 TV LA QM++ +YMH G++H D+K N L+GL + A Q Y++D+GLA F T Sbjct: 159 TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHF---VTG 215 Query: 209 KHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKK 388 P K GT Y S + HLGV +RR DLE LGY L+ +L LPW K Sbjct: 216 DFKP-DPKKMHNGTIEYTSRDAHLGV-PTRRADLEILGYNLIEWLGAELPWVTQKLLAVP 273 Query: 389 QKYDKISEKKMLTPVEVL----CKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 K K E M E L K P + Y L +PDY + F Sbjct: 274 PKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWF 328
>YOO1_CAEEL (P34633) Putative serine/threonine-protein kinase ZK507.1 (EC| 2.7.11.1) Length = 331 Score = 85.1 bits (209), Expect = 1e-16 Identities = 56/173 (32%), Positives = 91/173 (52%), Gaps = 1/173 (0%) Frame = +2 Query: 32 TVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHK 211 T+L Q + + HQ GFLHRDIKP N+ +G G K+ +Y++D+GLA+K+R L + Sbjct: 92 TILQCGLQTMKAIHDFHQIGFLHRDIKPANYCIGYGSKSETIYVLDFGLARKYR-LPNGQ 150 Query: 212 HIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL-PWQGLKAGTKK 388 P R + GT RY S +H E RRDD ES ++ + + +L W+GL T+ Sbjct: 151 VRPPRPKTKMIGTPRYCSRASHRCEELGRRDDYESWFFMFIDLVDTTLIDWKGL---TRP 207 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 Y K ++++ T ++ K + IS Y +L ++ + + L+ D Sbjct: 208 DAYAK--KQELFTKLKTYEKHPMFKVISI--YLDNLVYDSEVKFGVLREAITD 256
>YMX8_CAEEL (P34516) Putative serine/threonine-protein kinase K06H7.1 (EC| 2.7.11.1) Length = 346 Score = 84.3 bits (207), Expect = 2e-16 Identities = 60/180 (33%), Positives = 87/180 (48%), Gaps = 5/180 (2%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVY--IIDYGLAKKF---RDLQTHKHIPYREN 232 ++ +H G+LHRD+KP N MG A++ Y ++D+GLA+++ D P RE Sbjct: 129 IKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRP-REK 187 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISE 412 GTARY SV H EQ R DDL +L Y+L +R L W + +I E Sbjct: 188 TYFRGTARYCSVAMHDRYEQGRVDDLWALVYILAE-MRCRLAWHDVDDKV------EIGE 240 Query: 413 KKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDW 592 K EVL P + +S+ RS F +PDY L +L D+ Y++ + W Sbjct: 241 MKRKIHDEVLFAKSPVQMLSFVKTVRSTLFYHRPDYEKLFKLLEDVMKCANYKWSDPYHW 300
>YKL2_CAEEL (P42169) Putative casein kinase I C03C10.2 in chromosome III (EC| 2.7.11.1) Length = 363 Score = 80.1 bits (196), Expect = 4e-15 Identities = 42/120 (35%), Positives = 70/120 (58%), Gaps = 1/120 (0%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQV-YIIDYGLAKKFR 193 + S +TV +A Q +N ++ +H G++HRD+KP N G+ + + Y++D+GL ++F+ Sbjct: 166 RLSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFK 225 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK 373 ++ IP+R N GT RY SV H +EQ+ DD S+ Y + G LPW+ L+ Sbjct: 226 T-ESGVCIPWRINAGFKGTERYVSVRVHEKLEQTPWDDAFSVLYTAYELVVGELPWRYLE 284
>VRK3_MOUSE (Q8K3G5) Serine/threonine-protein kinase VRK3 (EC 2.7.11.1)| (Vaccinia-related kinase 3) Length = 453 Score = 78.2 bits (191), Expect = 2e-14 Identities = 48/175 (27%), Positives = 86/175 (49%), Gaps = 5/175 (2%) Frame = +2 Query: 23 SLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQ 202 S + VL +A ++++ +EY+H+ ++H ++ +N + +QV ++ YG +R Sbjct: 258 SERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVN-PEDLSQVTLVGYGFT--YRYCP 314 Query: 203 THKHIPYRENKNLT--GTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 KH+ Y+E G + S++ H G SRR DL++LGY ++ +L GSLPW Sbjct: 315 GGKHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLP 374 Query: 377 GTKK---QKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLK 532 T+K QK + + L + Y +L +E+KP Y+ L+ Sbjct: 375 NTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATLR 429
>KC1D_BOVIN (P35508) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) (Fragment) Length = 42 Score = 77.4 bits (189), Expect = 3e-14 Identities = 34/42 (80%), Positives = 39/42 (92%) Frame = +2 Query: 131 GLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTAR 256 GLG+K N VYIID+GLAKK+RD +TH+HIPYRENKNLTGTAR Sbjct: 1 GLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTAR 42
>YQI1_CAEEL (Q09503) Hypothetical protein C45G9.1 in chromosome III| Length = 290 Score = 77.0 bits (188), Expect = 4e-14 Identities = 56/203 (27%), Positives = 96/203 (47%), Gaps = 9/203 (4%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGR---KANQVYIIDYGLA 181 ++ FS T + Q + ++Y+H GF+HR++ N +G + +A ++I+D+GL Sbjct: 53 NKGFSRGTWSRVGIQWVYALKYVHYNGFIHRNVNTQNLFLGNEKDSERAKIIHILDFGLG 112 Query: 182 KKFRDLQTHKHIPY----RENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRG 349 + F ++ R + G+ RYAS N HL EQ R DD+ SL YV++ G Sbjct: 113 RPFARYHARENKWIVRIARHSAEFRGSFRYASPNVHLRKEQGRVDDVWSLPYVIIELNGG 172 Query: 350 -SLPWQGLKAGTKKQKYDKISEKKM-LTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYS 523 +LPWQ + ++ + K+ LTP +V+ P+ + SL + +PD Sbjct: 173 KALPWQ------TDYRRGRVEQMKLNLTPKDVM-SDMPACMDKLMPHLASLNYYQRPDDH 225 Query: 524 YLKRLFRDLFIREGYQFDYVFDW 592 + + F + E FDW Sbjct: 226 MIFKCFWQVMENEKITPSSKFDW 248
>VRK3_HUMAN (Q8IV63) Serine/threonine-protein kinase VRK3 (EC 2.7.11.1)| (Vaccinia-related kinase 3) Length = 474 Score = 75.9 bits (185), Expect = 8e-14 Identities = 51/175 (29%), Positives = 87/175 (49%), Gaps = 5/175 (2%) Frame = +2 Query: 23 SLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQ 202 S ++VL +A ++++ +E++H+ ++H ++ +N + +QV + YG A FR Sbjct: 279 SERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD-PEDQSQVTLAGYGFA--FRYCP 335 Query: 203 THKHIPYRENKNLT--GTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 + KH+ Y E G + S++ H G SRR DL+SLGY ++ +L G LPW Sbjct: 336 SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLP 395 Query: 377 GTKKQKYDKISEKKMLTPVEVLCKSY--PSEFI-SYFHYCRSLRFEDKPDYSYLK 532 T+ K P C + PSE + Y +L +E+KP Y+ L+ Sbjct: 396 NTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 450
>PKND_CHLMU (Q9PK92) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 74.7 bits (182), Expect = 2e-13 Identities = 54/157 (34%), Positives = 81/157 (51%), Gaps = 16/157 (10%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA--KKF 190 K S+K L + D++ VEY+H KG LHRD+KPDN L+GL +V I+D+G A K Sbjct: 109 KTSVKAFLPIFDKICATVEYIHSKGVLHRDLKPDNILLGL---FGEVVIVDWGAAIFKHA 165 Query: 191 RDLQT-----------HKHIPYRENK---NLTGTARYASVNTHLGVEQSRRDDLESLGYV 328 ++LQ K+I Y + GT Y + + LG E S + D+ +LG + Sbjct: 166 KELQQEKDEEGFSSYGQKNICYSSMTVPGKIVGTPDYMAPESLLGAEASEKTDIYALGLI 225 Query: 329 LMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEV 439 L L S P++ K +K Y E +L+P+E+ Sbjct: 226 LYQMLTLSFPYRRKKG--RKLPY----EDSILSPIEM 256
>PKND_CHLTR (O84303) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 71.6 bits (174), Expect = 2e-12 Identities = 51/157 (32%), Positives = 82/157 (52%), Gaps = 16/157 (10%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA--KKF 190 K S+K+ L + D++ VEY+H KG LHRD+KPDN L+GL +V IID+G A K Sbjct: 109 KTSVKSFLPIFDKICATVEYIHSKGVLHRDLKPDNILLGL---FGEVVIIDWGAAIFKHA 165 Query: 191 RDLQTHKH----IPYRENK----------NLTGTARYASVNTHLGVEQSRRDDLESLGYV 328 ++L+ + + + E + GT Y + + LGVE S + D+ +LG + Sbjct: 166 KELKLEQDDEAAVSFDERNICYSSMTIPGKIVGTPDYMAPESLLGVEASEKTDIYALGLI 225 Query: 329 LMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEV 439 L L + P++ K +K Y + +L P+E+ Sbjct: 226 LYQMLTLAFPYRRKKG--RKLSYRDV----VLPPIEM 256
>YOO3_CAEEL (P34635) Putative serine/threonine-protein kinase ZK507.3 (EC| 2.7.11.1) Length = 374 Score = 69.7 bits (169), Expect = 6e-12 Identities = 51/173 (29%), Positives = 85/173 (49%), Gaps = 1/173 (0%) Frame = +2 Query: 32 TVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHK 211 T+L Q + + HQ GFLHRDIKP N+ +G G K+ +Y++D+GLA+K+R Sbjct: 134 TILQCGLQTMKAIHDFHQIGFLHRDIKPANYCIGYGSKSETIYVLDFGLARKYR------ 187 Query: 212 HIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL-PWQGLKAGTKK 388 +P Y S +H E RRDD ES ++ + + +L W+GL T+ Sbjct: 188 -LP----------EWYCSRASHRCEELGRRDDYESWFFMFIDLVDTTLIDWKGL---TRP 233 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 Y K ++++ T ++ K + IS Y +L ++ + +L+ D Sbjct: 234 DAYAK--KQELFTKLKTYEKEPMFKVISI--YLDTLVYDSDVKFGFLRDAITD 282
>PKND_CHLCV (Q822K5) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 930 Score = 62.8 bits (151), Expect = 7e-10 Identities = 55/188 (29%), Positives = 89/188 (47%), Gaps = 12/188 (6%) Frame = +2 Query: 23 SLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYG--LAKKFRD 196 S+ T L + ++ + VEY+H +G LHRD+KPDN L+GL ++V I+D+G L+K+ + Sbjct: 111 SVATFLSIFHKICSTVEYVHSRGILHRDLKPDNILLGL---FSEVVILDWGAALSKEMEE 167 Query: 197 ---LQTHKHIPYRENKNLT------GTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRG 349 IP N+T GT Y + G S D+ +LG +L L Sbjct: 168 DFLSDIDVRIPGSLFSNMTIPGKIVGTPDYMAPERLRGTPASESTDIYALGVILYQMLTL 227 Query: 350 SLPWQGLKAGTKKQKYDKISEKKMLT-PVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSY 526 S P+ +K+K KIS + ++ P E+ F+S R+L + + Y Sbjct: 228 SFPY-------RKKKGQKISLRHQISFPEEIAPHREIPPFLSQV-VMRALAADPRERYRS 279 Query: 527 LKRLFRDL 550 + L D+ Sbjct: 280 VSALKADI 287
>PKND_CHLPN (Q9Z986) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 932 Score = 62.0 bits (149), Expect = 1e-09 Identities = 55/194 (28%), Positives = 87/194 (44%), Gaps = 14/194 (7%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA--- 181 + K S+ L + ++ +EY+H +G LHRD+KPDN L+GL ++ I+D+G A Sbjct: 107 AEKTSVGAFLSIFHKICCTIEYVHSRGILHRDLKPDNILLGL---FSEAVILDWGAAVAC 163 Query: 182 -----------KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYV 328 K L + IP R + GT Y + LG S+ D+ +LG V Sbjct: 164 GEEEDLLDIDVSKEEVLSSRMTIPGR----IVGTPDYMAPERLLGHPASKSTDIYALGVV 219 Query: 329 LMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFED 508 L L S P++ KK K + +++ +P EV F+S R L + Sbjct: 220 LYQMLTLSFPYR-----RKKGKKIVLDGQRIPSPQEVAPYREIPPFLSAV-VMRMLAVDP 273 Query: 509 KPDYSYLKRLFRDL 550 + YS + L D+ Sbjct: 274 QERYSSVTELKEDI 287
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 60.8 bits (146), Expect = 3e-09 Identities = 42/129 (32%), Positives = 62/129 (48%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 QM N ++YMH K LHRDIKP+N L+G N + + D+G + D Q + Sbjct: 206 QMANALDYMHSKNILHRDIKPENILIGFN---NTIKLTDFGWSVYNEDGQ--------KR 254 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISE 412 K L GT Y S E + + D+ +LG + L GS P++ TK+ Y +I Sbjct: 255 KTLCGTIDYLSPELIKSREYNNKVDVWALGVLTYELLVGSPPFE---EDTKEMTYRRILR 311 Query: 413 KKMLTPVEV 439 + P+ V Sbjct: 312 CDLKFPLNV 320
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 60.8 bits (146), Expect = 3e-09 Identities = 37/128 (28%), Positives = 61/128 (47%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 +++FS + QM N + Y+H+K +HRDIKP+N L+G+ ++ + D+G + Sbjct: 181 AKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKPENILLGID---GEIKLSDFGWS--- 234 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 H P L GT Y G E + + DL SLG + FL G+ P++ + Sbjct: 235 ------VHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFEDM 288 Query: 371 KAGTKKQK 394 + K Sbjct: 289 SGHSATYK 296
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 59.7 bits (143), Expect = 6e-09 Identities = 39/127 (30%), Positives = 65/127 (51%), Gaps = 2/127 (1%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ V ++H+KG +HRD+KP+N LM + V + D+GLAK+F + + Sbjct: 246 EIVSAVSHLHEKGIMHRDLKPENILMDVD---GHVMLTDFGLAKEFEE--------NTRS 294 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKY--DKI 406 ++ GT Y + G + D S+G +L L G P+ G K G +QK DKI Sbjct: 295 NSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSK-GKIQQKIVKDKI 353 Query: 407 SEKKMLT 427 + L+ Sbjct: 354 KLPQFLS 360
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 59.3 bits (142), Expect = 8e-09 Identities = 52/183 (28%), Positives = 85/183 (46%), Gaps = 2/183 (1%) Frame = +2 Query: 23 SLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQ 202 S++TVL LA + +EY+H +G +HRD+K +N L+ +V + D+G + L+ Sbjct: 185 SIETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLL---NDEMRVKVADFGTS----CLE 237 Query: 203 THKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGT 382 T RE K GT R+ + +R+ D+ S G VL LP+QG+ T Sbjct: 238 TQ----CREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPFQGM---T 290 Query: 383 KKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFR--DLFI 556 Q ++EK P+ C+ + I C S +PD+S + + D + Sbjct: 291 PVQAAFAVAEKNERPPLPASCQPALAHLIK---RCWSENPSKRPDFSNIVAVLEKYDECV 347 Query: 557 REG 565 +EG Sbjct: 348 KEG 350
>PKN1_MYXXA (P33973) Serine/threonine-protein kinase pkn1 (EC 2.7.11.1)| Length = 693 Score = 58.9 bits (141), Expect = 1e-08 Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 3/117 (2%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDN-FLMGLGRKANQVYIIDYGLAKKFRDLQTHK 211 V+ + Q+ + ++ H +G +HRD+KPDN FL+ A V ++D+G+AK Sbjct: 157 VVSVLSQVCDALQAAHARGIVHRDLKPDNIFLVRRNGNAPFVKVLDFGIAK-----LADA 211 Query: 212 HIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW--QGLKA 376 H+P + GT Y + LG R DL +LG + L G LP+ +GL A Sbjct: 212 HMPQTHAGIIVGTPEYMAPEQSLGRGVDGRADLYALGVIAYQLLTGRLPFNDEGLAA 268
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 58.9 bits (141), Expect = 1e-08 Identities = 39/127 (30%), Positives = 64/127 (50%), Gaps = 2/127 (1%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ V ++H+KG +HRD+KP+N LM V + D+GLAK+F + + Sbjct: 240 EIVSAVSHLHEKGIMHRDLKPENILMDTD---GHVMLTDFGLAKEFEE--------NTRS 288 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKY--DKI 406 ++ GT Y + G + D S+G +L L G P+ G K G +QK DKI Sbjct: 289 NSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSK-GKIQQKIVKDKI 347 Query: 407 SEKKMLT 427 + L+ Sbjct: 348 KLPQFLS 354
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/138 (29%), Positives = 60/138 (43%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF + ++ N + Y H K +HRDIKP+N L+G A ++ I D+G + Sbjct: 227 KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG---SAGELKIADFGWS----- 278 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 H P L GT Y G + DL SLG + FL G P++ A Sbjct: 279 ----VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---A 331 Query: 377 GTKKQKYDKISEKKMLTP 430 T ++ Y +IS + P Sbjct: 332 NTYQETYKRISRVEFTFP 349
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 57.8 bits (138), Expect = 2e-08 Identities = 33/104 (31%), Positives = 53/104 (50%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++N ++Y H+ G +HRDIKP N ++ + V ++D+G+A+ D +++ Sbjct: 130 VLNALDYSHRMGIIHRDIKPGNIMIS---EQGVVKVMDFGIARALDD----SAATMTQSQ 182 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + GTA+Y S G R DL S G VL L G P+ G Sbjct: 183 GVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYEMLTGRPPFTG 226
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 57.4 bits (137), Expect = 3e-08 Identities = 33/103 (32%), Positives = 53/103 (51%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ + Y+HQ+G HRD+KP+N L+ + + V I D+G+A FR + + R Sbjct: 126 QLLSGLNYLHQRGIAHRDLKPENLLLD---EHDNVKISDFGMATMFRCKGKERLLDKR-- 180 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 GT Y + ++ DL S G +L+ L G LPW Sbjct: 181 ---CGTLPYVAPEVLQKAYHAQPADLWSCGVILVTMLAGELPW 220
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 56.6 bits (135), Expect = 5e-08 Identities = 32/110 (29%), Positives = 52/110 (47%) Frame = +2 Query: 38 LMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHI 217 L L Q+ + +H KG +HRD+KP+N + + Q ++D+G+A R ++ Sbjct: 113 LPLLQQLAEGLAAIHDKGIIHRDLKPENVFISKSARGEQARLLDFGIA---RLVEPDAAS 169 Query: 218 PYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + + GT Y S +G + R DL S G + L G LP+ G Sbjct: 170 SVSQIGVVLGTPEYLSPEQAVGAKVDTRSDLYSFGVLTYRVLSGRLPFDG 219
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 56.2 bits (134), Expect = 7e-08 Identities = 37/103 (35%), Positives = 50/103 (48%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+ + Y+H G +HRD+KP N ++ R QV ++D+GLAK D E Sbjct: 227 QICEALAYIHGHGLVHRDLKPSNIMVDDDR---QVRLMDFGLAKFLAD-----DAAITEA 278 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 L GT RY + LG R DL SLG +L L G P+ Sbjct: 279 GKLVGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPF 321
>PKNA_MYCTU (P65726) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 55.8 bits (133), Expect = 9e-08 Identities = 40/129 (31%), Positives = 60/129 (46%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 + SL+ L + +Q ++ H G +HRD+KP N L+ QV I D+G+AK Sbjct: 112 RLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILI---TPTGQVKITDFGIAKAV-- 166 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 P + + GTA+Y + LG + S D+ SLG V + G P+ G A Sbjct: 167 ----DAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGA 222 Query: 377 GTKKQKYDK 403 T K+ K Sbjct: 223 LTVAMKHIK 231
>PKNA_MYCBO (P65727) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 55.8 bits (133), Expect = 9e-08 Identities = 40/129 (31%), Positives = 60/129 (46%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 + SL+ L + +Q ++ H G +HRD+KP N L+ QV I D+G+AK Sbjct: 112 RLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILI---TPTGQVKITDFGIAKAV-- 166 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 P + + GTA+Y + LG + S D+ SLG V + G P+ G A Sbjct: 167 ----DAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGA 222 Query: 377 GTKKQKYDK 403 T K+ K Sbjct: 223 LTVAMKHIK 231
>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) Length = 984 Score = 55.8 bits (133), Expect = 9e-08 Identities = 47/172 (27%), Positives = 72/172 (41%), Gaps = 7/172 (4%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F + V+ Q+++ V +H+ G LHRDIK N + KAN + + DYGLAKK Sbjct: 148 FEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFL---TKANLIKLGDYGLAKKLNS- 203 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 Y + L GT Y S GV+ + + D+ ++G V+ L Sbjct: 204 ------EYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELL------------ 245 Query: 380 TKKQKYDKISEKKM-------LTPVEVLCKSYPSEFISYFHYCRSLRFEDKP 514 T K+ +D + + + +EV Y E I H C E +P Sbjct: 246 TLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRP 297
>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8) Length = 979 Score = 55.8 bits (133), Expect = 9e-08 Identities = 47/172 (27%), Positives = 72/172 (41%), Gaps = 7/172 (4%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F + V+ Q+++ V +H+ G LHRDIK N + KAN + + DYGLAKK Sbjct: 148 FEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFL---TKANLIKLGDYGLAKKLNS- 203 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 Y + L GT Y S GV+ + + D+ ++G V+ L Sbjct: 204 ------EYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELL------------ 245 Query: 380 TKKQKYDKISEKKM-------LTPVEVLCKSYPSEFISYFHYCRSLRFEDKP 514 T K+ +D + + + +EV Y E I H C E +P Sbjct: 246 TLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRP 297
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 55.5 bits (132), Expect = 1e-07 Identities = 49/141 (34%), Positives = 65/141 (46%), Gaps = 9/141 (6%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+I VEY+H G HRDIKP+N L+ + +Q+ I D+GLA FR H N Sbjct: 113 QLIAGVEYLHSIGITHRDIKPENLLLD---ERDQLKISDFGLATVFR----HNGKERLLN 165 Query: 233 KNLTGTARYASVNTHLGVEQSRRD--DLESLGYVLMYFLRGSLPW-------QGLKAGTK 385 K + GT Y + + D D+ S G VL L G LPW Q + Sbjct: 166 K-MCGTLPYVAPEL-IKSRAFHADPVDVWSCGIVLTAMLAGELPWDQPNEVCQEYCDWKE 223 Query: 386 KQKYDKISEKKMLTPVEVLCK 448 K Y +K TP+ +LCK Sbjct: 224 KNHYLTPWKKISATPLALLCK 244
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 55.5 bits (132), Expect = 1e-07 Identities = 38/129 (29%), Positives = 66/129 (51%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 QM + ++YMH++ LHRDIKP+N ++G N + + D+G + + T K + Sbjct: 215 QMADALDYMHERNILHRDIKPENIIIGFN---NTIKLTDFGWS-----VITPKG---SKR 263 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISE 412 K L GT Y S E + + D+ +LG + L GS P++ +K+ Y +I + Sbjct: 264 KTLCGTVDYLSPELIRSREYNEKVDVWALGVLTYELLVGSPPFE---EESKELTYKRILK 320 Query: 413 KKMLTPVEV 439 + ++ P V Sbjct: 321 RNLIFPDHV 329
>KIN4_YEAST (Q01919) Serine/threonine-protein kinase KIN4 (EC 2.7.11.1)| Length = 800 Score = 55.1 bits (131), Expect = 2e-07 Identities = 40/126 (31%), Positives = 61/126 (48%), Gaps = 7/126 (5%) Frame = +2 Query: 5 YCSRKFSLK--TVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGL 178 Y RK LK + L Q+I+ V YMH KG +HRD+K +N L+ K + I D+G Sbjct: 140 YIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLD---KHENLVITDFGF 196 Query: 179 AKKFRDLQTHKHIPYREN---KNLTGTARYASVNTHLGVE--QSRRDDLESLGYVLMYFL 343 +F + +N K G+ YA+ + + ++R+ D+ S G +L L Sbjct: 197 VNEF----------FEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAML 246 Query: 344 RGSLPW 361 G LPW Sbjct: 247 AGYLPW 252
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/148 (28%), Positives = 66/148 (44%), Gaps = 6/148 (4%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMG--LGRKAN----QVYII 166 + R S T+ + Q+ + +H KG +HRD+KP N L+ GR+AN +V I Sbjct: 105 HAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIA 164 Query: 167 DYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR 346 D+G A R LQ++ L G+ Y + + + DL S+G ++ L Sbjct: 165 DFGFA---RYLQSNMMA-----ATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLT 216 Query: 347 GSLPWQGLKAGTKKQKYDKISEKKMLTP 430 G P+Q + Y+K K L P Sbjct: 217 GKAPFQASSPQDLRLFYEK---NKTLVP 241
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 54.7 bits (130), Expect = 2e-07 Identities = 35/121 (28%), Positives = 58/121 (47%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK 184 + RK + L + ++ +EY H+ G +HRDIKP N ++ + QV ++D+G+A+ Sbjct: 105 HSGRKLLPERTLEMTIGILQALEYSHRAGIVHRDIKPANVML---TRNGQVKVMDFGIAR 161 Query: 185 KFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 D + + + GTA+Y S G + R DL S G +L L P+ Sbjct: 162 AMGD----SGMTMTQTAAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPFV 217 Query: 365 G 367 G Sbjct: 218 G 218
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 54.7 bits (130), Expect = 2e-07 Identities = 38/129 (29%), Positives = 60/129 (46%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 + SL+ L + +Q ++ H G +HRD+KP N L+ QV I D+G+AK Sbjct: 112 RLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILI---TPTGQVKITDFGIAKAV-- 166 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 P + + GTA+Y + LG + + D+ SLG + + G P+ G A Sbjct: 167 ----DAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVYSLGVIGYEVVSGKRPFTGDGA 222 Query: 377 GTKKQKYDK 403 T K+ K Sbjct: 223 LTVAMKHIK 231
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 54.7 bits (130), Expect = 2e-07 Identities = 32/100 (32%), Positives = 49/100 (49%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 + + HQ G +HRD+KP N ++ N V ++D+G+A+ D + + + G Sbjct: 126 LNFSHQNGIIHRDVKPANIMIS---ATNAVKVMDFGIARAIADSTS-----VTQTAAVIG 177 Query: 248 TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 TA+Y S G R D+ SLG VL L G P+ G Sbjct: 178 TAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPPFIG 217
>PKH3_ASHGO (Q753D9) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| Length = 726 Score = 54.7 bits (130), Expect = 2e-07 Identities = 33/105 (31%), Positives = 54/105 (51%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ VEY+H G +HRD+KP+N L+ K ++ I D+G A + Sbjct: 119 QLVDTVEYIHSMGVIHRDLKPENVLLD---KEGRLMIADFGAAYTVGQSDAGSD-GDKPA 174 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + GTA Y S L + D+ +LG +L FL+G+ P++G Sbjct: 175 TSFVGTAEYVSPELLLENKSYYSSDVWALGCMLYQFLQGTPPFRG 219
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 54.3 bits (129), Expect = 3e-07 Identities = 32/100 (32%), Positives = 48/100 (48%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 + + HQ G +HRD+KP N ++ N V ++D+G+A+ D + + G Sbjct: 126 LNFSHQNGIIHRDVKPANIMIS---ATNAVKVMDFGIARAIADSGN----SVTQTAAVIG 178 Query: 248 TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 TA+Y S G R D+ SLG VL L G P+ G Sbjct: 179 TAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 218
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 54.3 bits (129), Expect = 3e-07 Identities = 32/100 (32%), Positives = 48/100 (48%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 + + HQ G +HRD+KP N ++ N V ++D+G+A+ D + + G Sbjct: 126 LNFSHQNGIIHRDVKPANIMIS---ATNAVKVMDFGIARAIADSGN----SVTQTAAVIG 178 Query: 248 TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 TA+Y S G R D+ SLG VL L G P+ G Sbjct: 179 TAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 218
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 54.3 bits (129), Expect = 3e-07 Identities = 40/138 (28%), Positives = 59/138 (42%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF + ++ N + Y H K +HRDIKP+N L+G ++ I D+G + Sbjct: 220 KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG---SNGELKIADFGWS----- 271 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 H P L GT Y G + DL SLG + FL G P++ A Sbjct: 272 ----VHAPSSRRTTLCGTLDYQPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFE---A 324 Query: 377 GTKKQKYDKISEKKMLTP 430 T ++ Y +IS + P Sbjct: 325 HTYQETYRRISRVEFTFP 342
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 3/122 (2%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 +F + L Q++ + Y+H KG LHRD+K DN L+ + I D+G+++K +D Sbjct: 1274 RFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLD---QDGICKISDFGISRKSKD 1330 Query: 197 LQTHKHIPYRENKNLTGTARYAS---VNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + ++ + R GT + + V+T G S + D+ SLG +++ G PW Sbjct: 1331 IYSNSDMTMR------GTVFWMAPEMVDTKQG--YSAKVDIWSLGCIVLEMFAGKRPWSN 1382 Query: 368 LK 373 L+ Sbjct: 1383 LE 1384
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 54.3 bits (129), Expect = 3e-07 Identities = 45/172 (26%), Positives = 72/172 (41%), Gaps = 18/172 (10%) Frame = +2 Query: 47 ADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYR 226 A Q+I+ ++Y+H G +HRDIKP+N L+ K + + D+G AK P Sbjct: 284 AAQIIDAIDYLHSNGIIHRDIKPENILLDGEMK---IKLTDFGTAKLLNPTNNSVSKPEY 340 Query: 227 E----NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQK 394 + +K+ GTA Y S R D+ + G +L + G P++ QK Sbjct: 341 DLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQK 400 Query: 395 YDKIS--------------EKKMLTPVEVLCKSYPSEFISYFHYCRSLRFED 508 K+ KK+L V+ L + I H+ + L F+D Sbjct: 401 VMKVQYAFTPGFPLIIRDLVKKIL--VKNLDRRLTISQIKEHHFFKDLNFKD 450
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 53.9 bits (128), Expect = 3e-07 Identities = 38/123 (30%), Positives = 58/123 (47%), Gaps = 4/123 (3%) Frame = +2 Query: 5 YCSRKFSLKTV--LMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGL 178 Y +K LK + L Q+I+ V Y+H KG +HRD+K +N L+ K + I D+G Sbjct: 140 YIQKKRRLKEMNACRLFSQLISGVHYIHSKGLVHRDLKLENLLLD---KNENLVITDFGF 196 Query: 179 AKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVE--QSRRDDLESLGYVLMYFLRGS 352 +F K G+ YA+ + E ++R+ D+ S G +L L G Sbjct: 197 VNEFCSRN-------ELMKTSCGSPCYAAPELVISAEPYEARKADIWSCGVILYAILAGY 249 Query: 353 LPW 361 LPW Sbjct: 250 LPW 252
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 53.9 bits (128), Expect = 3e-07 Identities = 43/145 (29%), Positives = 65/145 (44%), Gaps = 6/145 (4%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL--GRKAN----QVYIIDYG 175 R S TV + Q+ + +H KG +HRD+KP N L+ GR+AN +V I D+G Sbjct: 108 RTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFG 167 Query: 176 LAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 A R LQ++ L G+ Y + + + DL S+G ++ L G Sbjct: 168 FA---RYLQSNMMA-----ATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKA 219 Query: 356 PWQGLKAGTKKQKYDKISEKKMLTP 430 P+Q + Y+K K L P Sbjct: 220 PFQASSPQDLRLFYEK---NKTLVP 241
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 53.9 bits (128), Expect = 3e-07 Identities = 34/113 (30%), Positives = 54/113 (47%) Frame = +2 Query: 29 KTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTH 208 + + + ++ +E H+ G +HRD+KP N L+ + V + D+G+AK D T Sbjct: 108 EVAISIGIKVAKALECAHKSGIIHRDVKPQNILV---TEEGVVKVTDFGIAKSM-DSSTI 163 Query: 209 KHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 H ++ G+A Y S G R DL SLG VL + G +P+ G Sbjct: 164 AH-----TNSVMGSAHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTGVVPFNG 211
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 53.5 bits (127), Expect = 4e-07 Identities = 39/138 (28%), Positives = 59/138 (42%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF + ++ N + Y H K +HRDIKP+N L+G ++ I D+G + Sbjct: 218 KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG---SNGELKIADFGWS----- 269 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 H P + GT Y G + DL SLG + FL G P++ A Sbjct: 270 ----VHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFE---A 322 Query: 377 GTKKQKYDKISEKKMLTP 430 T ++ Y +IS + P Sbjct: 323 HTYQETYRRISRVEFTFP 340
>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase) Length = 944 Score = 53.5 bits (127), Expect = 4e-07 Identities = 37/108 (34%), Positives = 53/108 (49%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F +TVL Q+++ V +H+ G LHRDIK N + KAN + + DYGLAK+ Sbjct: 130 FQEETVLWYLFQIVSAVSCIHKAGILHRDIKTLNIFL---TKANLIKLGDYGLAKQLSS- 185 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFL 343 Y + GT Y S GV+ S + D+ ++G VL L Sbjct: 186 ------EYSMAETCVGTLYYMSPEICQGVKYSFKSDIWAVGCVLYELL 227
>PKSC_STRCO (Q9S2C0) Serine/threonine protein kinase pksC (EC 2.7.11.1)| Length = 556 Score = 53.5 bits (127), Expect = 4e-07 Identities = 33/108 (30%), Positives = 53/108 (49%) Frame = +2 Query: 38 LMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHI 217 L + ++ +E H+ G +HRDIKP N +M K V ++D+G+A+ + T Sbjct: 129 LKITADVLAALEISHEMGLVHRDIKPGNVMM---TKRGVVKVMDFGIARAMQSGVT---- 181 Query: 218 PYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 + + GT +Y S LG R DL S+G +L + G LP+ Sbjct: 182 SMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVTGRLPF 229
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 53.1 bits (126), Expect = 6e-07 Identities = 32/116 (27%), Positives = 56/116 (48%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF+ K Q+++ V Y+HQ+ +HRD+KP+N L +Q+ + D+G+AK + Sbjct: 113 KFTEKDASQTIRQVLDAVNYLHQRNIVHRDLKPENLLYLTRDLDSQLVLADFGIAKMLDN 172 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 P ++ G+ YA+ L + D+ SLG + L G P++ Sbjct: 173 -------PAEVLTSMAGSFGYAAPEVMLKQGHGKAVDIWSLGVITYTLLCGYSPFR 221
>YWY3_CAEEL (Q11090) Putative serine/threonine-protein kinase C01C4.3 (EC| 2.7.11.1) Length = 407 Score = 53.1 bits (126), Expect = 6e-07 Identities = 30/103 (29%), Positives = 55/103 (53%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 +++ +E+MH + +HR++K +N L+ ++V + D+GL +K T K++ Y N Sbjct: 235 VLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKVD--TTVKYLEYVNNY 292 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 + VN L V +S D+ +LG + Y ++G PWQ Sbjct: 293 HAAELCD-TVVNEKLVVNKS--TDIWALGIIFFYCMKGKFPWQ 332
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 53.1 bits (126), Expect = 6e-07 Identities = 35/114 (30%), Positives = 56/114 (49%) Frame = +2 Query: 26 LKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQT 205 +K + +A Q+ +++ H+ +HRDIKP N L+ + V + D+G+A+ Sbjct: 108 VKRAVEIASQVCRALDHAHKNKIIHRDIKPQNILV---TDEDVVKVTDFGIARAANGAT- 163 Query: 206 HKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 I Y ++ GTA Y S G R D+ SLG VL L G +P++G Sbjct: 164 ---ITY--TGDVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGKVPFEG 212
>PKH1_YEAST (Q03407) Serine/threonine-protein kinase PKH1 (EC 2.7.11.1)| (3-phosphoinositide-dependent protein kinase 1) Length = 766 Score = 53.1 bits (126), Expect = 6e-07 Identities = 40/126 (31%), Positives = 59/126 (46%), Gaps = 6/126 (4%) Frame = +2 Query: 47 ADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD--LQTHKHIP 220 A Q+I+ V+ +H G +HRDIKP+N L+ K +V + D+G AK + T P Sbjct: 230 ASQIIDAVDSLHNIGIIHRDIKPENILLD---KNMKVKLTDFGTAKILPEEPSNTADGKP 286 Query: 221 ----YRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKK 388 Y ++K+ GTA Y S R D+ + G +L L G P++ Sbjct: 287 YFDLYAKSKSFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAANEYLTF 346 Query: 389 QKYDKI 406 QK KI Sbjct: 347 QKVMKI 352
>YR436_MIMIV (Q7T6Y1) Putative serine/threonine-protein kinase R436 (EC| 2.7.11.1) Length = 276 Score = 52.8 bits (125), Expect = 8e-07 Identities = 35/121 (28%), Positives = 61/121 (50%), Gaps = 3/121 (2%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F L ++ + Q+++ + YMH +HRDIKPDN L+ ++V++ID+ L+ D Sbjct: 104 FKLYYIIDILIQVVDAISYMHDNNIVHRDIKPDNILLN-----DKVHLIDFDLS----DQ 154 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQ--SRRDDLESLGYVLMYFL-RGSLPWQGL 370 + P R K GT + + + Q ++ D+ SLG + Y L + LP++ Sbjct: 155 LDNPKFPVR--KGTIGTPNFMAPEIWWKINQVDYKKTDIYSLGITMYYLLNKRKLPYKAK 212 Query: 371 K 373 K Sbjct: 213 K 213
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 52.8 bits (125), Expect = 8e-07 Identities = 41/141 (29%), Positives = 66/141 (46%), Gaps = 9/141 (6%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVY-IIDYGLAKKFRDLQTHKHIPY-R 226 Q+++ + YMH+ +HRD+KP+N L+ K + + IID+GL+ H Y + Sbjct: 175 QVLSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLS---------THFEYSK 225 Query: 227 ENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG-------LKAGTK 385 + K+ GTA Y + + G + D+ S G +L L G P+ G K T Sbjct: 226 KMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETG 284 Query: 386 KQKYDKISEKKMLTPVEVLCK 448 K +D KK+ + L K Sbjct: 285 KYTFDLPQFKKISDKAKDLIK 305
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 52.8 bits (125), Expect = 8e-07 Identities = 41/141 (29%), Positives = 66/141 (46%), Gaps = 9/141 (6%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVY-IIDYGLAKKFRDLQTHKHIPY-R 226 Q+++ + YMH+ +HRD+KP+N L+ K + + IID+GL+ H Y + Sbjct: 175 QVLSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLS---------THFEYSK 225 Query: 227 ENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG-------LKAGTK 385 + K+ GTA Y + + G + D+ S G +L L G P+ G K T Sbjct: 226 KMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETG 284 Query: 386 KQKYDKISEKKMLTPVEVLCK 448 K +D KK+ + L K Sbjct: 285 KYTFDLPQFKKISDKAKDLIK 305
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 52.8 bits (125), Expect = 8e-07 Identities = 32/117 (27%), Positives = 55/117 (47%), Gaps = 1/117 (0%) Frame = +2 Query: 29 KTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQ-T 205 K L + +Q+++ + + HQ +HRDIKP N L+ + + D+G+A T Sbjct: 109 KEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILID---HMGNIKVTDFGIATALSSTTIT 165 Query: 206 HKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 H ++ G+ Y S G +++ D+ +LG VL L G +P+ G A Sbjct: 166 H-------TNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESA 215
>MPH1_SCHPO (O94235) Serine/threonine-protein kinase mph1 (EC 2.7.12.2)| Length = 678 Score = 52.4 bits (124), Expect = 1e-06 Identities = 37/127 (29%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 + +L + M +QM+ V+ +H + +H D+KP NFL+ G + +ID+G+AK Sbjct: 412 KPINLNFIRMYWEQMLEAVQVVHDQNIVHSDLKPANFLLVEG----NLKLIDFGIAKAIG 467 Query: 194 DLQTHKH-------IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGS 352 + T+ H I Y + LT + + L V+ R D+ SLG +L + G Sbjct: 468 NDTTNIHRDSHIGTINYMAPEALTDMNAHTNSGVKL-VKLGRPSDVWSLGCILYQMVYGR 526 Query: 353 LPWQGLK 373 P+ LK Sbjct: 527 APFAHLK 533
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 52.0 bits (123), Expect = 1e-06 Identities = 34/106 (32%), Positives = 55/106 (51%), Gaps = 3/106 (2%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 QM + V+Y+H +G HRD+KPDN L+ + + + D+GL+K + Sbjct: 286 QMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSV--------M 337 Query: 233 KNLTGTARYASVNTHL--GVE-QSRRDDLESLGYVLMYFLRGSLPW 361 + L GT Y + + G E +++ D+ SLG VL L G+LP+ Sbjct: 338 RTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPF 383
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 52.0 bits (123), Expect = 1e-06 Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 7/109 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK-------KFRDLQTHKH 214 +++ ++YMH +G +HRD+KP+N L+ + I D+G AK + H Sbjct: 207 IVDSIDYMHGRGVIHRDLKPENILLDDNMRTK---ITDFGSAKILNSSHGSHEEDTHHAD 263 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 P +++ GTARY S D+ + G +L L G P+ Sbjct: 264 KPQAHSRSFVGTARYVSPEVLSDKIAGTASDIWAFGCILFQMLAGKPPF 312
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 51.6 bits (122), Expect = 2e-06 Identities = 37/119 (31%), Positives = 61/119 (51%), Gaps = 2/119 (1%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 + FS + ++++ V +MH G +HRD+KP+N L ++ +ID+G A+ Sbjct: 578 KHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFAR--- 634 Query: 194 DLQTHKHIPYRENKNLTGTARYAS--VNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 L+ + P K T YA+ + TH G ++S DL SLG +L L G +P+Q Sbjct: 635 -LKPPDNQPL---KTPCFTLHYAAPELLTHNGYDES--CDLWSLGVILYTMLSGQVPFQ 687 Score = 41.2 bits (95), Expect = 0.002 Identities = 29/117 (24%), Positives = 58/117 (49%), Gaps = 2/117 (1%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 +F+ V + +++ +E++H+ G ++RDIK +N L+ V + D+GL+K+F Sbjct: 147 RFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD---SNGHVVLTDFGLSKEFVA 203 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVE--QSRRDDLESLGYVLMYFLRGSLPW 361 +T + + GT Y + + G + + D SLG ++ L G+ P+ Sbjct: 204 DETERAYSF------CGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF 254
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 51.6 bits (122), Expect = 2e-06 Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 3/107 (2%) Frame = +2 Query: 53 QMINRVEYMHQK-GFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRE 229 Q+++ + Y+H + G HRDIKP+N L+ K + + D+GLA +FR K R Sbjct: 124 QLVSAINYLHVECGVAHRDIKPENILLD---KNGNLKLADFGLASQFR----RKDGTLRV 176 Query: 230 NKNLTGTARYASVNTHLGVE--QSRRDDLESLGYVLMYFLRGSLPWQ 364 + + G+ Y + E + R D+ S+G +L L G PW+ Sbjct: 177 SMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLLTGQTPWE 223
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 51.6 bits (122), Expect = 2e-06 Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 2/107 (1%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVY-IIDYGLAKKFRDLQTHKHIPY-R 226 Q+++ + YMH+ +HRD+KP+N L+ K + + IID+GL+ H Y + Sbjct: 175 QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLS---------THFEYSK 225 Query: 227 ENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + K+ GTA Y + + G + D+ S G +L L G P+ G Sbjct: 226 KMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNG 271
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 51.6 bits (122), Expect = 2e-06 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 7/172 (4%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F + V ++ Q++ + Y+H KG +HRD+K DN L+ I D+G++K Sbjct: 927 FEEQLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCK---ISDFGISK----- 978 Query: 200 QTHKHIPYRENKNLT------GTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 H Y + NL+ A N H G S + D+ SLG V++ L G PW Sbjct: 979 --HSDNVYDNDANLSMQGSIFWMAPEVIHNDHQG--YSAKVDVWSLGCVVLEMLAGRRPW 1034 Query: 362 QGLKAGTKKQKYDKISEKKMLTPV-EVLCKSYPSEFISYFHYCRSLRFEDKP 514 +A Q K+ +K P+ L E I + + C ++ + +P Sbjct: 1035 STDEA---IQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRP 1083
>KBN8_YEAST (P38070) Probable serine/threonine-protein kinase YBR028C (EC| 2.7.11.1) Length = 525 Score = 51.6 bits (122), Expect = 2e-06 Identities = 39/132 (29%), Positives = 63/132 (47%), Gaps = 3/132 (2%) Frame = +2 Query: 32 TVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK-FRDLQTH 208 TV A ++ + ++H KG ++RD+KP+N L+ + + + D+GL+KK D Sbjct: 253 TVSFYAAEISCALRFLHTKGVVYRDLKPENCLL---NQRGHLVLTDFGLSKKSANDSAVD 309 Query: 209 KHIPYRENK--NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGT 382 + P N ++ GT Y + LG S+ D SLG +L L G P+ G Sbjct: 310 EEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTG---SN 366 Query: 383 KKQKYDKISEKK 418 K +KI + K Sbjct: 367 HKVIINKIQQNK 378
>SPEG_BRARE (Q696W0) Striated muscle preferentially expressed protein kinase (EC| 2.7.11.1) Length = 2995 Score = 51.6 bits (122), Expect = 2e-06 Identities = 51/198 (25%), Positives = 82/198 (41%), Gaps = 18/198 (9%) Frame = +2 Query: 5 YCSRK-----------FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKAN 151 YCS K +S V+ Q++ +EY+H LH DIKPDN ++ N Sbjct: 2757 YCSGKEILQNLIDRFCYSEDDVVGFIVQILQGLEYLHNCKILHLDIKPDNIMV---TNLN 2813 Query: 152 QVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVL 331 + IID+G A++F L + Y GT Y + G D+ SLG + Sbjct: 2814 VIKIIDFGSAQRFNPLSLQQCSRY------LGTLEYMAPEMLKGDLVGPPADIWSLGVLS 2867 Query: 332 MYFLRGSLPWQGLKAGTKKQKYD--KISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFE 505 L G P++ + K K K+ V ++ + ++ + +CR + Sbjct: 2868 YIMLSGRHPFEDKDPQLTEAKIHEAKFDSTKLYPKVSQSASTFLKKILNSYPWCRP-TIK 2926 Query: 506 DKPDY-----SYLKRLFR 544 D ++ SYLK+L R Sbjct: 2927 DCLNHSWLHDSYLKKLRR 2944 Score = 44.7 bits (104), Expect = 2e-04 Identities = 19/47 (40%), Positives = 31/47 (65%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 Q++ +EY+HQ +H D+KP+N LM +K +Q+ I D+G A K + Sbjct: 1355 QLLEGIEYLHQNDIIHLDLKPENILMA-DQKTDQIRICDFGNALKVK 1400
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 51.2 bits (121), Expect = 2e-06 Identities = 31/104 (29%), Positives = 53/104 (50%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ ++Y+HQ+G LHRD+K NF + + ++ + D+GLA + P + Sbjct: 168 QILSGLKYLHQRGILHRDLKLGNFFI---TENMELKVGDFGLAARLEP-------PEQRK 217 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 K + GT Y + L D+ SLG V+ L GS P++ Sbjct: 218 KTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFE 261
>PKNJ_MYCTU (P65732) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 51.2 bits (121), Expect = 2e-06 Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQ-VYIIDYGLAKKFRDLQTHKHIPYRE 229 ++ ++Y HQ+G +HRDIKP NFL+ ++ V + D+G+A+ D Sbjct: 119 EVAKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFGIARALGD------TGLTS 172 Query: 230 NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 ++ T YA+ G R DL SLG L L G P+ Sbjct: 173 TGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPF 216
>PKNJ_MYCBO (P65733) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 51.2 bits (121), Expect = 2e-06 Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQ-VYIIDYGLAKKFRDLQTHKHIPYRE 229 ++ ++Y HQ+G +HRDIKP NFL+ ++ V + D+G+A+ D Sbjct: 119 EVAKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFGIARALGD------TGLTS 172 Query: 230 NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 ++ T YA+ G R DL SLG L L G P+ Sbjct: 173 TGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPF 216
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 51.2 bits (121), Expect = 2e-06 Identities = 35/119 (29%), Positives = 53/119 (44%), Gaps = 1/119 (0%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQK-GFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 R FS + +++ V +MH++ G +HRD+KP+N L V IID+G A+ Sbjct: 499 RLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFAR-- 556 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 P + T +YA+ DL SLG +L L G +P+QG Sbjct: 557 ----LRPQSPAEPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQG 611 Score = 38.5 bits (88), Expect = 0.015 Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 3/122 (2%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK 184 Y + F V + +++ +E++H+ G ++RD+K +N L+ + + D+GL+K Sbjct: 128 YQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLD---SEGHIVLTDFGLSK 184 Query: 185 KFRDLQTHKHIPYRENKNLTGTARYAS---VNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 +F + + + GT Y + + + G + D SLG +L L G+ Sbjct: 185 EFLTEEKERTFSF------CGTIEYMAPEIIRSKAG--HGKAVDWWSLGILLFELLTGAS 236 Query: 356 PW 361 P+ Sbjct: 237 PF 238
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 51.2 bits (121), Expect = 2e-06 Identities = 34/118 (28%), Positives = 61/118 (51%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ +EY+H KG +HRD+KP+N L+ + + I D+G AK + + + R N Sbjct: 191 EIVSALEYLHGKGIIHRDLKPENILL---NEDMHIQITDFGTAK----VLSPESKQARAN 243 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKI 406 + GTA+Y S + DL +LG ++ + G P+ +AG + + KI Sbjct: 244 -SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPF---RAGNEYLIFQKI 297
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 51.2 bits (121), Expect = 2e-06 Identities = 42/123 (34%), Positives = 58/123 (47%), Gaps = 1/123 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q++ V Y+H G HRDIKP+N L+ + + + I D+GLA FR H + N Sbjct: 113 QLMAGVVYLHGIGITHRDIKPENLLLD---ERDNLKISDFGLATVFR----HNNRERLLN 165 Query: 233 KNLTGTARYASVNTHLGVE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKIS 409 K + GT Y + E + D+ S G VL L G LPW + Q+Y Sbjct: 166 K-MCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK 222 Query: 410 EKK 418 EKK Sbjct: 223 EKK 225
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 51.2 bits (121), Expect = 2e-06 Identities = 42/123 (34%), Positives = 58/123 (47%), Gaps = 1/123 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q++ V Y+H G HRDIKP+N L+ + + + I D+GLA FR H + N Sbjct: 113 QLMAGVVYLHGIGITHRDIKPENLLLD---ERDNLKISDFGLATVFR----HNNRERLLN 165 Query: 233 KNLTGTARYASVNTHLGVE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKIS 409 K + GT Y + E + D+ S G VL L G LPW + Q+Y Sbjct: 166 K-MCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK 222 Query: 410 EKK 418 EKK Sbjct: 223 EKK 225
>KGP25_DROME (P32023) cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 (EC| 2.7.11.12) (CGK) (Foraging protein) Length = 934 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/149 (24%), Positives = 66/149 (44%), Gaps = 9/149 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ +Y+H + ++RD+KP+N L+ + V ++D+G AKK LQT R+ Sbjct: 731 VVEAFDYLHSRNIIYRDLKPENLLL---NERGYVKLVDFGFAKK---LQTG-----RKTW 779 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L G+ P+ G + G Sbjct: 780 TFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDA 839 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSEFISY 475 ++ + + ++ LC+ P+E + Y Sbjct: 840 IEFPRNITRNASNLIKKLCRDNPAERLGY 868
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 51.2 bits (121), Expect = 2e-06 Identities = 40/141 (28%), Positives = 62/141 (43%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+R ++ L + Q+ + Y H K +HRDIKP+N L+G ++ I D+G + Sbjct: 232 CTRFDDQRSALYIK-QLAEALLYCHSKKVIHRDIKPENLLLG---SNGELKIADFGWS-- 285 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 H P L GT Y G + DL SLG + FL G P++ Sbjct: 286 -------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE- 337 Query: 368 LKAGTKKQKYDKISEKKMLTP 430 T ++ Y +IS+ + P Sbjct: 338 --TDTHQETYRRISKVEFQYP 356
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 51.2 bits (121), Expect = 2e-06 Identities = 34/118 (28%), Positives = 61/118 (51%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ +EY+H KG +HRD+KP+N L+ + + I D+G AK + + + R N Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILL---NEDMHIQITDFGTAK----VLSPESKQARAN 240 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKI 406 + GTA+Y S + DL +LG ++ + G P+ +AG + + KI Sbjct: 241 -SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPF---RAGNEYLIFQKI 294
>KGP24_DROME (Q03043) cGMP-dependent protein kinase, isozyme 2 forms| cD4/T1/T3A/T3B (EC 2.7.11.12) (CGK) (Foraging protein) Length = 1088 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/149 (24%), Positives = 66/149 (44%), Gaps = 9/149 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ +Y+H + ++RD+KP+N L+ + V ++D+G AKK LQT R+ Sbjct: 885 VVEAFDYLHSRNIIYRDLKPENLLL---NERGYVKLVDFGFAKK---LQTG-----RKTW 933 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L G+ P+ G + G Sbjct: 934 TFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDA 993 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSEFISY 475 ++ + + ++ LC+ P+E + Y Sbjct: 994 IEFPRNITRNASNLIKKLCRDNPAERLGY 1022
>KK31_SCHPO (Q9HFF4) Probable serine/threonine-protein kinase C110.01 (EC| 2.7.11.1) Length = 1023 Score = 50.8 bits (120), Expect = 3e-06 Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 8/124 (6%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 R+ L Q+I+ V Y+H +G +HRD+K +N L+ R + I D+G A F Sbjct: 593 RRLEDSVACRLFAQLISGVAYLHSRGVVHRDLKLENILLDTNR---NIVIADFGFATTFG 649 Query: 194 DLQT-HKHIPYRENKNL----TGTARYAS---VNTHLGVEQSRRDDLESLGYVLMYFLRG 349 T +H E +L G+ YA+ VN G+ + D+ S G +L L G Sbjct: 650 HFNTLSEHSLPTEKPDLFSTSCGSPCYAAPELVNCKSGMYAGTQADIWSCGVILYAMLAG 709 Query: 350 SLPW 361 LP+ Sbjct: 710 YLPF 713
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 50.8 bits (120), Expect = 3e-06 Identities = 38/121 (31%), Positives = 55/121 (45%), Gaps = 5/121 (4%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+ + + Y+H + HRDIKP+NFL + + IID+GLA F D+ E Sbjct: 215 QIFSVLNYLHIRNICHRDIKPENFLFYDKSTESLIKIIDFGLAAYFNDID-------YEM 267 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG-----LKAGTKKQKY 397 K GT Y + G + DL S G + L G P+ G + + KK KY Sbjct: 268 KTKAGTPYYVAPQVLTGC-YDYKCDLWSAGVLFYIILCGYPPFYGESDHEILSMVKKGKY 326 Query: 398 D 400 + Sbjct: 327 N 327
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 50.8 bits (120), Expect = 3e-06 Identities = 41/141 (29%), Positives = 60/141 (42%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C+R F + M Q+ + Y H K +HRDIKP+N L+G ++ I D+G + Sbjct: 232 CTR-FDDQRSAMYIKQLAEALLYCHSKKVIHRDIKPENLLLG---SNGELKIADFGWS-- 285 Query: 188 FRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 H P L GT Y G DL SLG + FL G P++ Sbjct: 286 -------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDETVDLWSLGVLCYEFLVGKPPFE- 337 Query: 368 LKAGTKKQKYDKISEKKMLTP 430 T ++ Y +IS+ + P Sbjct: 338 --TDTHQETYRRISKVEFQYP 356
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 50.8 bits (120), Expect = 3e-06 Identities = 46/175 (26%), Positives = 78/175 (44%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ ++Y+HQ+G LHRD+K NF + ++ + D+GLA + P + Sbjct: 137 QILSGLKYLHQRGILHRDLKLGNFFI---TDNMELKVGDFGLAARLEP-------PEQRK 186 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISE 412 K + GT Y + L D+ SLG V+ L GS P++ K+ Y I + Sbjct: 187 KTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFE---TADLKETYRCIKQ 243 Query: 413 KKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFD 577 P + S P+ + S R D+P ++++ R F +GY D Sbjct: 244 VHYTLPASL---SLPARQLLAAILRASPR--DRPS---IEQILRHDFFTKGYTPD 290
>PLK3_MOUSE (Q60806) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) Length = 631 Score = 50.8 bits (120), Expect = 3e-06 Identities = 46/175 (26%), Positives = 78/175 (44%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ ++Y+HQ+G LHRD+K NF + ++ + D+GLA + P + Sbjct: 169 QILSGLKYLHQRGILHRDLKLGNFFI---TDNMELKVGDFGLAARLEP-------PEQRK 218 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISE 412 K + GT Y + L D+ SLG V+ L GS P++ K+ Y I + Sbjct: 219 KTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFE---TADLKETYRCIKQ 275 Query: 413 KKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFD 577 P + S P+ + S R D+P ++++ R F +GY D Sbjct: 276 VHYTLPASL---SLPARQLLAAILRASPR--DRPS---IEQILRHDFFTKGYTPD 322
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 50.8 bits (120), Expect = 3e-06 Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 15/185 (8%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 QM+ V+Y+H+ G +HRD+KP+N L+ + + I D+G +K + Sbjct: 334 QMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSL--------M 385 Query: 233 KNLTGTARYASVNTHLG---VEQSRRDDLESLGYVLMYFLRGSLPWQ------GLKAGTK 385 + L GT Y + + SR D SLG +L L G P+ LK Sbjct: 386 RTLCGTPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQIT 445 Query: 386 KQKYDKISE------KKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 KY+ I E ++ L V+ L P ++ +D+ Y+K+ F+D Sbjct: 446 SGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWLQDE----YMKKKFQD 501 Query: 548 LFIRE 562 L ++E Sbjct: 502 LLVQE 506
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 50.4 bits (119), Expect = 4e-06 Identities = 32/118 (27%), Positives = 56/118 (47%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ +EY+H KG +HRD+KP+N L+ + + I D+G AK Sbjct: 191 EIVSALEYLHGKGIIHRDLKPENILL---NEDMHIQITDFGTAKVLSPDSKQARA----- 242 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKI 406 + GTA+Y S + DL +LG ++ + G P+ +AG + + KI Sbjct: 243 NSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPF---RAGNEYLIFQKI 297
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 50.4 bits (119), Expect = 4e-06 Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ V +MH G +HRD+KP+N L +++ IID+G A+ L+ + P Sbjct: 517 RLVSAVSHMHDVGVVHRDLKPENLLFTDETDNSEIKIIDFGFAR----LKPPDNQPL--- 569 Query: 233 KNLTGTARYAS--VNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 K T YA+ + H G ++S DL SLG +L L G +P+Q Sbjct: 570 KTPCFTLHYAAPELFNHNGYDES--CDLWSLGVILYTMLSGQVPFQ 613 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/117 (23%), Positives = 57/117 (48%), Gaps = 2/117 (1%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 +FS V + +++ +E++H+ G ++RDIK +N L+ V + D+GL+K+F Sbjct: 138 RFSENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILLD---SDGHVVLTDFGLSKEFLT 194 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVE--QSRRDDLESLGYVLMYFLRGSLPW 361 + + + GT Y + + G + + D S+G ++ L G+ P+ Sbjct: 195 DENERAYSF------CGTIEYMAPDIVRGGDTGHDKAVDWWSVGVLMYELLTGASPF 245
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 50.4 bits (119), Expect = 4e-06 Identities = 35/122 (28%), Positives = 55/122 (45%), Gaps = 16/122 (13%) Frame = +2 Query: 44 LADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKAN----------------QVYIIDYG 175 L Q++ ++Y+H++ +HRDIKP+N L+ + R+ N QV I D+G Sbjct: 308 LFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFG 367 Query: 176 LAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 LAK ++Q L GT Y + + + DL S G +L L G Sbjct: 368 LAKFTGEMQF--------TNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFP 419 Query: 356 PW 361 P+ Sbjct: 420 PF 421
>M3K8_MOUSE (Q07174) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene) Length = 467 Score = 50.4 bits (119), Expect = 4e-06 Identities = 29/109 (26%), Positives = 55/109 (50%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKH 214 ++ + ++ ++++H K +H DIKP N + + + ++D+GL+ K + + Sbjct: 230 IIWVTKHILKGLDFLHSKKVIHHDIKPSNIVF----MSTKAVLVDFGLSVKMTE---DVY 282 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 +P K+L GT Y S L S + D+ SLG L++ G+ PW Sbjct: 283 LP----KDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPW 327
>MAST1_MOUSE (Q9R1L5) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1566 Score = 50.1 bits (118), Expect = 5e-06 Identities = 40/148 (27%), Positives = 69/148 (46%), Gaps = 8/148 (5%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK- 187 +R + +TVL L EY+H G +HRD+KPDN L+ + + D+GL+K Sbjct: 475 ARMYFAETVLAL--------EYLHNYGIVHRDLKPDNLLI---TSMGHIKLTDFGLSKMG 523 Query: 188 FRDLQTHKHIPYRE-------NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR 346 L T+ + + E +K + GT Y + L + D ++G +L FL Sbjct: 524 LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV 583 Query: 347 GSLPWQGLKAGTKKQKYDKISEKKMLTP 430 G +P+ G T ++ + ++ +L P Sbjct: 584 GCVPFFG---DTPEELFGQVISDDILWP 608
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 50.1 bits (118), Expect = 5e-06 Identities = 35/119 (29%), Positives = 53/119 (44%), Gaps = 1/119 (0%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQK-GFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 R FS + +++ V +MH++ G +HRD+KP+N L V IID+G A+ Sbjct: 499 RHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFAR-- 556 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 P + T +YA+ DL SLG +L L G +P+QG Sbjct: 557 ----LRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQG 611 Score = 38.5 bits (88), Expect = 0.015 Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 3/122 (2%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK 184 Y + F V + +++ +E++H+ G ++RD+K +N L+ + + D+GL+K Sbjct: 128 YQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLD---SEGHIVLTDFGLSK 184 Query: 185 KFRDLQTHKHIPYRENKNLTGTARYAS---VNTHLGVEQSRRDDLESLGYVLMYFLRGSL 355 +F + + + GT Y + + + G + D SLG +L L G+ Sbjct: 185 EFLTEEKERTFSF------CGTIEYMAPEIIRSKTG--HGKAVDWWSLGILLFELLTGAS 236 Query: 356 PW 361 P+ Sbjct: 237 PF 238
>MAST1_RAT (Q810W7) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 50.1 bits (118), Expect = 5e-06 Identities = 40/148 (27%), Positives = 69/148 (46%), Gaps = 8/148 (5%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK- 187 +R + +TVL L EY+H G +HRD+KPDN L+ + + D+GL+K Sbjct: 476 ARMYFAETVLAL--------EYLHNYGIVHRDLKPDNLLI---TSMGHIKLTDFGLSKMG 524 Query: 188 FRDLQTHKHIPYRE-------NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR 346 L T+ + + E +K + GT Y + L + D ++G +L FL Sbjct: 525 LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV 584 Query: 347 GSLPWQGLKAGTKKQKYDKISEKKMLTP 430 G +P+ G T ++ + ++ +L P Sbjct: 585 GCVPFFG---DTPEELFGQVISDDILWP 609
>MAST1_HUMAN (Q9Y2H9) Microtubule-associated serine/threonine-protein kinase 1| (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 50.1 bits (118), Expect = 5e-06 Identities = 40/148 (27%), Positives = 69/148 (46%), Gaps = 8/148 (5%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK- 187 +R + +TVL L EY+H G +HRD+KPDN L+ + + D+GL+K Sbjct: 474 ARMYFAETVLAL--------EYLHNYGIVHRDLKPDNLLI---TSMGHIKLTDFGLSKMG 522 Query: 188 FRDLQTHKHIPYRE-------NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR 346 L T+ + + E +K + GT Y + L + D ++G +L FL Sbjct: 523 LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV 582 Query: 347 GSLPWQGLKAGTKKQKYDKISEKKMLTP 430 G +P+ G T ++ + ++ +L P Sbjct: 583 GCVPFFG---DTPEELFGQVISDDILWP 607
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 50.1 bits (118), Expect = 5e-06 Identities = 48/202 (23%), Positives = 85/202 (42%), Gaps = 11/202 (5%) Frame = +2 Query: 5 YCSRKFS---LKTVLMLAD--------QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKAN 151 YCSR+ LK +L + Q+++ ++Y+H++ LHRD+K NF + +A Sbjct: 158 YCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFI---NEAM 214 Query: 152 QVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVL 331 ++ + D+GLA + L+ + + GT Y S D+ +LG V+ Sbjct: 215 ELKVGDFGLAARLEPLE-------HRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVM 267 Query: 332 MYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDK 511 L G P++ K+ Y I E + P +L + H S+ ++ Sbjct: 268 YTMLLGRPPFE---TTNLKETYRCIREARYTMPSSLLAPAK--------HLIASMLSKNP 316 Query: 512 PDYSYLKRLFRDLFIREGYQFD 577 D L + R F +G+ D Sbjct: 317 EDRPSLDDIIRHDFFLQGFTPD 338
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 50.1 bits (118), Expect = 5e-06 Identities = 48/202 (23%), Positives = 85/202 (42%), Gaps = 11/202 (5%) Frame = +2 Query: 5 YCSRKFS---LKTVLMLAD--------QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKAN 151 YCSR+ LK +L + Q+++ ++Y+H++ LHRD+K NF + +A Sbjct: 158 YCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFI---NEAM 214 Query: 152 QVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVL 331 ++ + D+GLA + L+ + + GT Y S D+ +LG V+ Sbjct: 215 ELKVGDFGLAARLEPLE-------HRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVM 267 Query: 332 MYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDK 511 L G P++ K+ Y I E + P +L + H S+ ++ Sbjct: 268 YTMLLGRPPFE---TTNLKETYRCIREARYTMPSSLLAPAK--------HLIASMLSKNP 316 Query: 512 PDYSYLKRLFRDLFIREGYQFD 577 D L + R F +G+ D Sbjct: 317 EDRPSLDDIIRHDFFLQGFTPD 338
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 50.1 bits (118), Expect = 5e-06 Identities = 25/105 (23%), Positives = 50/105 (47%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 ++++ ++ H G +HRD+KP N L+ + V + D+G+AK + + Sbjct: 119 EILSAMDMAHSHGIIHRDLKPQNVLVS---SSGTVKVTDFGIAKALSETS------LTQT 169 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + G+ Y S G + + D+ ++G +L L G +P+ G Sbjct: 170 NTMFGSVHYLSPEQARGSNATVQSDIYAIGIILFELLTGQIPFDG 214
>PKH3_YEAST (Q03306) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| (Pkb-activating kinase homolog 3) Length = 898 Score = 50.1 bits (118), Expect = 5e-06 Identities = 30/115 (26%), Positives = 55/115 (47%), Gaps = 10/115 (8%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+I+ +E++H G +HRD+KP+N L+ + ++ I D+G A + + + Sbjct: 121 QLIDALEFIHSHGIIHRDLKPENVLLD---RDGRLMITDFGAAATIDPSLSGDSAKFNSD 177 Query: 233 KN----------LTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 N GTA Y S L + D+ +LG ++ F++G P++G Sbjct: 178 SNGSKDNQNCASFVGTAEYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRG 232
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 50.1 bits (118), Expect = 5e-06 Identities = 48/202 (23%), Positives = 85/202 (42%), Gaps = 11/202 (5%) Frame = +2 Query: 5 YCSRKFS---LKTVLMLAD--------QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKAN 151 YCSR+ LK +L + Q+++ ++Y+H++ LHRD+K NF + +A Sbjct: 161 YCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFI---NEAM 217 Query: 152 QVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVL 331 ++ + D+GLA + L+ + + GT Y S D+ +LG V+ Sbjct: 218 ELKVGDFGLAARLEPLE-------HRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVM 270 Query: 332 MYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDK 511 L G P++ K+ Y I E + P +L + H S+ ++ Sbjct: 271 YTMLLGRPPFE---TTNLKETYRCIREARYTMPSSLLAPAK--------HLIASMLSKNP 319 Query: 512 PDYSYLKRLFRDLFIREGYQFD 577 D L + R F +G+ D Sbjct: 320 EDRPSLDDIIRHDFFLQGFTPD 341
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 49.7 bits (117), Expect = 6e-06 Identities = 31/104 (29%), Positives = 49/104 (47%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+ N ++YMH+K +HRDIKP+N L+G N + + D+G + + P Sbjct: 210 QIANALDYMHKKNIIHRDIKPENILIGFN---NVIKLTDFG--------WSIINPPENRR 258 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 K + GT Y S E D +LG + L G+ P++ Sbjct: 259 KTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFE 302
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 49.7 bits (117), Expect = 6e-06 Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 1/110 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q++N V + H +G +HRD+KP+NFL + +Q+ ID+GL+ + P Sbjct: 259 QILNVVAFCHLQGVVHRDLKPENFLFKSKDEDSQLKAIDFGLSDYVK--------PDERL 310 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLP-WQGLKAG 379 ++ G+A Y + L S D+ S+G + L GS P W ++G Sbjct: 311 NDIVGSAYYVAPEV-LHRSYSTEADVWSIGVISYILLCGSRPFWARTESG 359
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 49.7 bits (117), Expect = 6e-06 Identities = 32/131 (24%), Positives = 62/131 (47%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 ++ K ++ Q+++ V+Y+H+ G +HRD+KP+N L + +++ I D+GL+K ++ Sbjct: 115 YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQN- 173 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 GT Y + S+ D S+G + L G P+ Sbjct: 174 --------GVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFY---EE 222 Query: 380 TKKQKYDKISE 412 T+ + ++KI E Sbjct: 223 TESKLFEKIKE 233
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 49.7 bits (117), Expect = 6e-06 Identities = 32/131 (24%), Positives = 62/131 (47%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 ++ K ++ Q+++ V+Y+H+ G +HRD+KP+N L + +++ I D+GL+K ++ Sbjct: 115 YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQN- 173 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 GT Y + S+ D S+G + L G P+ Sbjct: 174 --------GVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFY---EE 222 Query: 380 TKKQKYDKISE 412 T+ + ++KI E Sbjct: 223 TESKLFEKIKE 233
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 49.3 bits (116), Expect = 8e-06 Identities = 50/185 (27%), Positives = 77/185 (41%), Gaps = 15/185 (8%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 QM+ V+Y+H+ G +HRD+KP+N L+ + + I D+G +K + Sbjct: 330 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSL--------M 381 Query: 233 KNLTGTARYASVNTHLGV---EQSRRDDLESLGYVLMYFLRGSLPWQ------GLKAGTK 385 + L GT Y + + V +R D SLG +L L G P+ LK Sbjct: 382 RTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT 441 Query: 386 KQKYDKISE------KKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRD 547 KY+ I E +K L V+ L P + R +D+ +KR F+D Sbjct: 442 SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDED----MKRKFQD 497 Query: 548 LFIRE 562 L E Sbjct: 498 LLSEE 502
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 49.3 bits (116), Expect = 8e-06 Identities = 42/174 (24%), Positives = 70/174 (40%), Gaps = 8/174 (4%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA-KKFR 193 + S K + +A+ ++ + Y+H+K +HRDIKP N L+ + QV + D+G++ + Sbjct: 320 RISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILL---NENGQVKLCDFGVSGEAVN 376 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK 373 L T TGT+ Y + G S D+ SLG ++ G P K Sbjct: 377 SLAT----------TFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEK 426 Query: 374 AGTKKQKYDKISEKKMLTPVEVLCKSYPS-------EFISYFHYCRSLRFEDKP 514 ++ + TP K P F S+ YC ++P Sbjct: 427 MAANIAPFELLMWILTFTPE---LKDEPESNIIWSPSFKSFIDYCLKKDSRERP 477
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 49.3 bits (116), Expect = 8e-06 Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 28/134 (20%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQT--------- 205 Q++ + Y+H+ G +HRD+KP+N L+ + +D+G AKK + T Sbjct: 1373 QLLEGLAYLHESGIVHRDVKPENILLDFN---GVIKYVDFGAAKKIANNGTRLASMNKIE 1429 Query: 206 -----HKHIPY-------RENKN----LTGTARYASVNTHLGVEQSRR---DDLESLGYV 328 H+ + + + N+N + GT Y + + G + DD+ SLG V Sbjct: 1430 NADGEHEDVTHVSDSKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCV 1489 Query: 329 LMYFLRGSLPWQGL 370 ++ + G PW L Sbjct: 1490 VLEMITGRRPWANL 1503
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 49.3 bits (116), Expect = 8e-06 Identities = 32/131 (24%), Positives = 62/131 (47%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 ++ K ++ Q+++ V+Y+H+ G +HRD+KP+N L + +++ I D+GL+K ++ Sbjct: 115 YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQN- 173 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 GT Y + S+ D S+G + L G P+ Sbjct: 174 --------GIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFY---EE 222 Query: 380 TKKQKYDKISE 412 T+ + ++KI E Sbjct: 223 TESKLFEKIKE 233
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 49.3 bits (116), Expect = 8e-06 Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 1/123 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q++ V Y+H G HRDIKP+N L+ + + + I D+GLA FR + + Sbjct: 113 QLMAGVVYLHGIGITHRDIKPENLLLD---ERDNLKISDFGLATVFRYNNRERLL----- 164 Query: 233 KNLTGTARYASVNTHLGVE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKIS 409 + GT Y + E + D+ S G VL L G LPW + Q+Y Sbjct: 165 NKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK 222 Query: 410 EKK 418 EKK Sbjct: 223 EKK 225
>MKNK1_XENTR (Q66JF3) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 417 Score = 49.3 bits (116), Expect = 8e-06 Identities = 34/123 (27%), Positives = 53/123 (43%), Gaps = 5/123 (4%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 + F+ + + + + ++++H KG HRD+KP+N L K + V I D+ L + Sbjct: 128 KHFNEREASKVVKDIASALDFLHTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVK 187 Query: 194 DLQTHKHIPYRENKNLTGTARY-----ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLP 358 I E G+A Y V T +R DL SLG +L L G P Sbjct: 188 LNSACTPITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPP 247 Query: 359 WQG 367 + G Sbjct: 248 FVG 250
>MKNK1_XENLA (Q9YGW0) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 418 Score = 49.3 bits (116), Expect = 8e-06 Identities = 34/123 (27%), Positives = 53/123 (43%), Gaps = 5/123 (4%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 + F+ + + + + ++++H KG HRD+KP+N L K + V I D+ L + Sbjct: 128 KHFNEREASKVVKDIASALDFLHTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVK 187 Query: 194 DLQTHKHIPYRENKNLTGTARY-----ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLP 358 I E G+A Y V T +R DL SLG +L L G P Sbjct: 188 LNSACTTITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPP 247 Query: 359 WQG 367 + G Sbjct: 248 FVG 250
>MEK1_YEAST (P24719) Meiosis-specific serine/threonine-protein kinase MEK1 (EC| 2.7.11.1) Length = 497 Score = 49.3 bits (116), Expect = 8e-06 Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 15/135 (11%) Frame = +2 Query: 8 CSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKK 187 C S L++ Q++ + Y+H + +HRD+K DN L+ ++ + D+G+AK Sbjct: 258 CLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKD 317 Query: 188 FRDLQTHKH------------IPYRENKNLTGTARYASVNTHLGVEQSRRD---DLESLG 322 + H + +R N+ Y S + +EQ D DL SLG Sbjct: 318 LNSNKERMHTVVGTPEYCAPEVGFRANRK-----AYQSFSRAATLEQRGYDSKCDLWSLG 372 Query: 323 YVLMYFLRGSLPWQG 367 + L G P+ G Sbjct: 373 VITHIMLTGISPFYG 387
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 49.3 bits (116), Expect = 8e-06 Identities = 42/171 (24%), Positives = 72/171 (42%), Gaps = 4/171 (2%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK----KFRDLQ 202 V A ++++ +EYMH G +HRD+KP+N L V I D+G AK K+ + Sbjct: 155 VRFYAAEILSSIEYMHSCGIIHRDLKPENILFDGNM---HVKITDFGTAKILPPKYVNSP 211 Query: 203 THKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGT 382 + P + GTA Y + S+ DL + V+ + GS P+ G Sbjct: 212 DYTTFP----SSFVGTAEYVAPELLSRQVVSKSSDLWAFACVVYQMIVGSPPFHGSNPNN 267 Query: 383 KKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKR 535 KK+++ L K P + + F + ++ D+ +K+ Sbjct: 268 --------IFKKIMSLEYELPKLLPPDIVPLFSHLFRIQPSDRSTTQQIKQ 310
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 49.3 bits (116), Expect = 8e-06 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 1/111 (0%) Frame = +2 Query: 38 LMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVY-IIDYGLAKKFRDLQTHKH 214 L + +Q + + +H+ G +HRDIKP N L+ AN + I D+G+AK Sbjct: 126 LDVMEQAAHGLSVIHRMGLVHRDIKPGNMLI----TANGILKITDFGIAK------AAAS 175 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +P + GTA+Y S G + + D+ SLG V L G P+ G Sbjct: 176 VPLTRTGMVVGTAQYVSPEQAQGHQVTPASDVYSLGVVGYEMLSGRRPFTG 226
>M3K8_RAT (Q63562) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (Tumor progression locus 2) (TPL-2) Length = 467 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/109 (25%), Positives = 55/109 (50%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKH 214 ++ + ++ ++++H K +H DIKP N + + + ++D+GL+ + + + Sbjct: 230 IIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVF----MSTKAVLVDFGLSVQMTE---DVY 282 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 +P K+L GT Y S L S + D+ SLG L++ G+ PW Sbjct: 283 LP----KDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPW 327
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 48.9 bits (115), Expect = 1e-05 Identities = 39/137 (28%), Positives = 70/137 (51%), Gaps = 7/137 (5%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ V Y+H +G+ HRD+KP+N L + +++ +ID+GL K + + + H+ Sbjct: 115 QIVSAVAYVHSQGYAHRDLKPENLLFD---EYHKLKLIDFGLCAKPKGNKDY-HL----- 165 Query: 233 KNLTGTARYASV-----NTHLGVEQSRRDDLESLGYVLMYFLRGSLPW--QGLKAGTKKQ 391 + G+ YA+ ++LG E D+ S+G +L + G LP+ + A KK Sbjct: 166 QTCCGSLAYAAPELIQGKSYLGSEA----DVWSMGILLYVLMCGFLPFDDDNVMALYKKI 221 Query: 392 KYDKISEKKMLTPVEVL 442 K K L+P +L Sbjct: 222 MRGKYDVPKWLSPSSIL 238
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 48.9 bits (115), Expect = 1e-05 Identities = 31/114 (27%), Positives = 52/114 (45%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F ++M Q++ +EY+H G +HRDIK N L+ + + D+G +KK +L Sbjct: 168 FPEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVD---NKGCIRLADFGASKKVVEL 224 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 T K++ GT + + L S D+ S+G ++ G PW Sbjct: 225 AT-----VNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPW 273
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 48.9 bits (115), Expect = 1e-05 Identities = 40/137 (29%), Positives = 68/137 (49%), Gaps = 7/137 (5%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ V Y+H +G+ HRD+KP+N L K + +ID+GL K + + + H+ Sbjct: 115 QILSAVAYVHSQGYAHRDLKPENLLFDENHK---LKLIDFGLCAKPKGNKDY-HL----- 165 Query: 233 KNLTGTARYASV-----NTHLGVEQSRRDDLESLGYVLMYFLRGSLPW--QGLKAGTKKQ 391 + G+ YA+ ++LG E D+ S+G +L + G LP+ + A KK Sbjct: 166 QTCCGSLAYAAPELIQGKSYLGSEA----DVWSMGILLYVLMCGFLPFDDDNVMALYKKI 221 Query: 392 KYDKISEKKMLTPVEVL 442 K K L+P +L Sbjct: 222 MRGKYEVPKWLSPSSIL 238
>KPCT_HUMAN (Q04759) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 706 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/117 (27%), Positives = 53/117 (45%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF L A ++I ++++H KG ++RD+K DN L+ K + I D+G+ K+ Sbjct: 475 KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD---KDGHIKIADFGMCKE--- 528 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + + GT Y + LG + + D S G +L L G P+ G Sbjct: 529 ----NMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHG 581
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 48.9 bits (115), Expect = 1e-05 Identities = 29/115 (25%), Positives = 49/115 (42%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 K ++ A Q+ + + H+ G +HRDIKP N ++ + + + D+G+AK Sbjct: 104 KIEFNKIIDYATQIAKALNFAHKNGIVHRDIKPHNIMV---TDDDIIKVTDFGIAK---- 156 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 + G+A Y S G+ R D+ S G VL G +P+ Sbjct: 157 --ASNESTITTTNKVVGSAHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVPY 209
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 48.9 bits (115), Expect = 1e-05 Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 1/123 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+I V Y+H G HRD+KP+N L+ + + + I D+GLA F+ H N Sbjct: 113 QLIAGVVYLHSMGITHRDLKPENLLLD---ERDNLKISDFGLATVFK----HNGRERLLN 165 Query: 233 KNLTGTARYASVNTHLGVE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKIS 409 K + GT Y + E ++ D+ + G VL L G LPW + Q+Y Sbjct: 166 K-MCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAGELPWD--QPSDSCQEYSDWK 222 Query: 410 EKK 418 E+K Sbjct: 223 ERK 225
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 48.9 bits (115), Expect = 1e-05 Identities = 40/163 (24%), Positives = 67/163 (41%), Gaps = 10/163 (6%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 +K + + ++ + + Y H+K +HRDIKP+N L+GL +V I D+G + Sbjct: 109 QKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLN---GEVKISDFGWS---- 161 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK 373 H P K + GT Y + DL +G + L G P++ Sbjct: 162 -----VHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFE--- 213 Query: 374 AGTKKQKYDKISEKKMLTPVEV----------LCKSYPSEFIS 472 + T + Y +I + P V L + +PSE +S Sbjct: 214 SSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLS 256
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (Protein kinase PKX1) Length = 358 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/115 (27%), Positives = 52/115 (45%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 +FS T L + ++I +EY+H K ++RD+KP+N L+ + + + D+G AKK D Sbjct: 143 RFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLD---RDGHIKLTDFGFAKKLVD 199 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 L GT Y + R D +LG ++ L G P+ Sbjct: 200 ----------RTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPF 244
>MAST2_MOUSE (Q60592) Microtubule-associated serine/threonine-protein kinase 2| (EC 2.7.11.1) Length = 1734 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 8/129 (6%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK-KFRDLQTHKHIPYRE----- 229 +EY+H G +HRD+KPDN L+ + + D+GL+K L T+ + + E Sbjct: 564 LEYLHNYGIVHRDLKPDNLLI---TSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDARE 620 Query: 230 --NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDK 403 +K + GT Y + L + D ++G +L FL G +P+ G T ++ + + Sbjct: 621 FLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQ 677 Query: 404 ISEKKMLTP 430 + +++ P Sbjct: 678 VISDEIVWP 686
>AURKB_PIG (Q9N0X0) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-B) (Fragment) Length = 156 Score = 48.5 bits (114), Expect = 1e-05 Identities = 33/134 (24%), Positives = 58/134 (43%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 R F + + +++ + + Y H K +HRDIKP+N L+GL ++ I D+G + Sbjct: 21 RTFDEQRTATIMEELADALIYCHGKKVIHRDIKPENLLLGL---QGELKIADFGWS---- 73 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK 373 H P K + GT Y G + + DL +G + L G+ P++ Sbjct: 74 -----VHAPSLRRKTMRGTLDYLPPEMIEGRTHNEKVDLWCIGVLCYELLVGNPPFESAS 128 Query: 374 AGTKKQKYDKISEK 415 ++ K+ K Sbjct: 129 HNETYRRIVKVDLK 142
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 48.5 bits (114), Expect = 1e-05 Identities = 36/139 (25%), Positives = 60/139 (43%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 ++F+ T QM + Y+H K +HRDIKP+N L+ + + I D+G + Sbjct: 192 KRFTESTASSYIYQMSEALLYLHGKNIIHRDIKPENILLHFN---DTIKISDFGWS---- 244 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLK 373 H P L GT Y + D+ SLG ++ FL G+ P++ + Sbjct: 245 -----VHAPSNRRSTLCGTMDYLPPEIVQSRPYDKNVDVWSLGILMYEFLCGAPPFE--E 297 Query: 374 AGTKKQKYDKISEKKMLTP 430 G + Y +I + + P Sbjct: 298 PGGAQATYRRIVKLDLRIP 316
>KGP1_DROME (Q03042) cGMP-dependent protein kinase, isozyme 1 (EC 2.7.11.12)| (CGK) Length = 768 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/149 (22%), Positives = 63/149 (42%), Gaps = 9/149 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ EY+H +G ++RD+KP+N ++ + V I+D+G AK+ + Sbjct: 566 VLQAFEYLHARGIIYRDLKPENLMLD---ERGYVKIVDFGFAKQIGTSS--------KTW 614 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L R D +LG ++ L G+ P+ + G Sbjct: 615 TFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDM 674 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSEFISY 475 + K + + ++ LC+ PSE + Y Sbjct: 675 IAFPKHISRWAVQLIKRLCRDVPSERLGY 703
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 48.5 bits (114), Expect = 1e-05 Identities = 33/116 (28%), Positives = 57/116 (49%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F+ K + Q+ + + Y+H +HRD+KP+NFL K + + IID+GL+K +L Sbjct: 163 FTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSK---NL 219 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 T + + GT Y + L + ++ D+ S G ++ L G P+ G Sbjct: 220 GTGEFTTTK-----AGTPYYVAPQV-LDGKYDKKCDIWSSGVIMYTLLCGYPPFYG 269
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 48.5 bits (114), Expect = 1e-05 Identities = 31/118 (26%), Positives = 54/118 (45%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 SR F + + +++ + + Y H+K +HRDIKP+N L+GL ++ I D+G + Sbjct: 174 SRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGL---QGELKIADFGWS--- 227 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 H P K + GT Y G + DL +G + + G+ P++ Sbjct: 228 ------VHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFE 279
>PKN3_MYXXA (Q9XBQ0) Serine/threonine-protein kinase pkn3 (EC 2.7.11.1)| Length = 547 Score = 48.5 bits (114), Expect = 1e-05 Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 1/111 (0%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGR-KANQVYIIDYGLAKKFRDLQTHK 211 V+ + Q+++ + H G +HRD+KP+N ++ R + + V ++D+G+A K D T Sbjct: 119 VVRIVSQVLSALSDAHGAGVIHRDLKPENIMVEPRRNEPDFVKVLDFGIA-KITD-STDD 176 Query: 212 HIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 + GT Y S G + R DL ++G +L + G LP++ Sbjct: 177 GPALTRAGFVCGTPEYMSPEQARGSQLDHRSDLYAVGVILYQLMTGLLPFE 227
>MAST2_HUMAN (Q6P0Q8) Microtubule-associated serine/threonine-protein kinase 2| (EC 2.7.11.1) Length = 1798 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 8/129 (6%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK-KFRDLQTHKHIPYRE----- 229 +EY+H G +HRD+KPDN L+ + + D+GL+K L T+ + + E Sbjct: 623 LEYLHNYGIVHRDLKPDNLLI---TSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDARE 679 Query: 230 --NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDK 403 +K + GT Y + L + D ++G +L FL G +P+ G T ++ + + Sbjct: 680 FLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQ 736 Query: 404 ISEKKMLTP 430 + +++ P Sbjct: 737 VISDEIVWP 745
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 48.5 bits (114), Expect = 1e-05 Identities = 33/116 (28%), Positives = 57/116 (49%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F+ K + Q+ + + Y+H +HRD+KP+NFL K + + IID+GL+K +L Sbjct: 163 FTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSK---NL 219 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 T + + GT Y + L + ++ D+ S G ++ L G P+ G Sbjct: 220 GTGEFTTTK-----AGTPYYVAPQV-LDGKYDKKCDIWSSGVIMYTLLCGYPPFYG 269
>M3K8_HUMAN (P41279) Mitogen-activated protein kinase kinase kinase 8 (EC| 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene) Length = 467 Score = 48.1 bits (113), Expect = 2e-05 Identities = 28/109 (25%), Positives = 54/109 (49%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKH 214 ++ + ++ ++++H K +H DIKP N + + + ++D+GL+ + + + Sbjct: 230 IIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVF----MSTKAVLVDFGLSVQMTE---DVY 282 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 P K+L GT Y S L S + D+ SLG L++ G+ PW Sbjct: 283 FP----KDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPW 327
>PRKY_HUMAN (O43930) Serine/threonine-protein kinase PRKY (EC 2.7.11.1)| Length = 277 Score = 48.1 bits (113), Expect = 2e-05 Identities = 32/114 (28%), Positives = 51/114 (44%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 FS T L + ++I +EY+H K ++RD+KP+N L+ + + + D+G AKK D Sbjct: 144 FSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLD---RDGHIKLTDFGFAKKLVD- 199 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 L GT Y + R D +LG ++ L G P+ Sbjct: 200 ---------RTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPF 244
>RAN1_SCHPO (P08092) Negative regulator of sexual conjugation and meiosis (EC| 2.7.11.1) Length = 470 Score = 48.1 bits (113), Expect = 2e-05 Identities = 24/59 (40%), Positives = 35/59 (59%) Frame = +2 Query: 5 YCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 Y +KTV + Q+I+ VE+ H G HRD+KP+N + +G N VY+ D+GLA Sbjct: 113 YQGNSHLIKTVFL---QLISAVEHCHSVGIYHRDLKPENIM--VGNDVNTVYLADFGLA 166
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 48.1 bits (113), Expect = 2e-05 Identities = 41/170 (24%), Positives = 73/170 (42%), Gaps = 9/170 (5%) Frame = +2 Query: 74 YMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA--KKFRDLQTHKHIPYRE-----N 232 Y+H KG +H+D+KP+N L+ + + I D G+A K + L K +E Sbjct: 128 YLHDKGVIHKDLKPENILVD---RDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTK 184 Query: 233 KNLTGTARYASVN--THLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKI 406 KN GT Y + + + + + D+ S G VL P++ + +++ Sbjct: 185 KNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVIC---TEQFVIC 241 Query: 407 SEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDLFI 556 + VE + + P E IS C ED+P + ++ FR ++ Sbjct: 242 IKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYL 291
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 9/145 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ Y+H KG ++RD+KP+N ++ ++D+G AKK ++ Sbjct: 467 VVEAFAYLHSKGIIYRDLKPENLILD---HRGYAKLVDFGFAKKIGF--------GKKTW 515 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L GS P+ G + G Sbjct: 516 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 575 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSE 463 ++ K K ++ LC+ PSE Sbjct: 576 IEFPKKIAKNAANLIKKLCRDNPSE 600
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 9/145 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ Y+H KG ++RD+KP+N ++ ++D+G AKK ++ Sbjct: 467 VVEAFAYLHSKGIIYRDLKPENLILD---HRGYAKLVDFGFAKKIGF--------GKKTW 515 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L GS P+ G + G Sbjct: 516 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 575 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSE 463 ++ K K ++ LC+ PSE Sbjct: 576 IEFPKKIAKNAANLIKKLCRDNPSE 600
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 9/145 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ Y+H KG ++RD+KP+N ++ ++D+G AKK ++ Sbjct: 467 VVEAFAYLHSKGIIYRDLKPENLILD---HRGYAKLVDFGFAKKIGF--------GKKTW 515 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L GS P+ G + G Sbjct: 516 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 575 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSE 463 ++ K K ++ LC+ PSE Sbjct: 576 IEFPKKIAKNAANLIKKLCRDNPSE 600
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/131 (26%), Positives = 60/131 (45%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 +S + + Q++N V H G +HRD+KP+NFL+ K + D+GL+ + Sbjct: 177 YSERAAATICRQIVNVVHVCHFMGVMHRDLKPENFLLSSKDKDAMLKATDFGLSVFIEEG 236 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 + + +N+ G+A Y + L + D+ S G +L L G P+ A Sbjct: 237 KVY--------RNIVGSAYYVAPEV-LRRSYGKEIDIWSAGVILYILLSGVPPFW---AE 284 Query: 380 TKKQKYDKISE 412 +K +D I E Sbjct: 285 NEKGIFDAILE 295
>YP62_CAEEL (Q09437) Putative serine/threonine-protein kinase B0495.2 (EC| 2.7.11.1) Length = 719 Score = 48.1 bits (113), Expect = 2e-05 Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 3/180 (1%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 +++FS+ L Q+++ +E+MH+ LHRD+K N LM + I D+GLA+++ Sbjct: 453 NKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMS---HKGILKIADFGLAREY 509 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVE-QSRRDDLESLGYVLMYF--LRGSLPW 361 D P ++ ++ T Y S LG S D+ S+G ++ F L+ P Sbjct: 510 GD-------PLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEFILLKPLFPG 562 Query: 362 QGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLF 541 +G KK +M TP E + +P ++ ++L FE P Y+ L++ F Sbjct: 563 RGELEQIKK------IFMEMGTPTESI---WPG--VTELDGWKALTFEKYP-YNQLRKRF 610
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 48.1 bits (113), Expect = 2e-05 Identities = 47/195 (24%), Positives = 81/195 (41%), Gaps = 11/195 (5%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA--K 184 S S+K ++L ++I + Y+H KG +H+D+KP+N L+ + I D GLA K Sbjct: 109 STPLSVKGRIIL--EIIEGMCYLHGKGVIHKDLKPENILVD---NDFHIKIADLGLASFK 163 Query: 185 KFRDLQTHKHIPYRENKNLTGTAR------YASVNTHL---GVEQSRRDDLESLGYVLMY 337 + L +H RE + GTA+ Y HL + + + D+ S VL Sbjct: 164 MWSKLNNEEHNELRE---VDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220 Query: 338 FLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPD 517 P++ + K + + + C P E IS C E +P Sbjct: 221 IFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYC---PREIISLMKLCWEANPEARPT 277 Query: 518 YSYLKRLFRDLFIRE 562 + ++ FR ++ + Sbjct: 278 FPGIEEKFRPFYLSQ 292
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 9/145 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ Y+H KG ++RD+KP+N ++ ++D+G AKK ++ Sbjct: 483 VVEAFAYLHSKGIIYRDLKPENLILD---HRGYAKLVDFGFAKKIGF--------GKKTW 531 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L GS P+ G + G Sbjct: 532 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 591 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSE 463 ++ K K ++ LC+ PSE Sbjct: 592 IEFPKKIAKNAANLIKKLCRDNPSE 616
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 9/145 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ Y+H KG ++RD+KP+N ++ ++D+G AKK ++ Sbjct: 483 VVEAFAYLHSKGIIYRDLKPENLILD---HRGYAKLVDFGFAKKIGF--------GKKTW 531 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L GS P+ G + G Sbjct: 532 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 591 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSE 463 ++ K K ++ LC+ PSE Sbjct: 592 IEFPKKIAKNAANLIKKLCRDNPSE 616
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 9/145 (6%) Frame = +2 Query: 56 MINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENK 235 ++ Y+H KG ++RD+KP+N ++ ++D+G AKK ++ Sbjct: 483 VVEAFAYLHSKGIIYRDLKPENLILD---HRGYAKLVDFGFAKKIGF--------GKKTW 531 Query: 236 NLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG---------LKAGTKK 388 GT Y + L D SLG ++ L GS P+ G + G Sbjct: 532 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 591 Query: 389 QKYDKISEKKMLTPVEVLCKSYPSE 463 ++ K K ++ LC+ PSE Sbjct: 592 IEFPKKIAKNAANLIKKLCRDNPSE 616
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 47.8 bits (112), Expect = 2e-05 Identities = 34/140 (24%), Positives = 62/140 (44%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F + + +++ + + Y H K +HRDIKP+N L+GL ++ I D+G + Sbjct: 172 FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWS------ 222 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 H P K + GT Y G + + DL +G + L G+ P++ + Sbjct: 223 ---VHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFE---SA 276 Query: 380 TKKQKYDKISEKKMLTPVEV 439 + + Y +I + + P V Sbjct: 277 SHNETYRRIVKVDLKFPASV 296
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 47.8 bits (112), Expect = 2e-05 Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 2/136 (1%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 R+F+ T Q+ ++Y+H K +HRDIKP+N L+ N + + D+G + Sbjct: 241 RRFNDATASHYIYQVALALDYLHTKHIIHRDIKPENILLSTD---NCIKLSDFGWSV--- 294 Query: 194 DLQTHKHIPYRENKNLT--GTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 K +P K LT GT Y E D+ SLG + FL G P++ Sbjct: 295 -----KSLPSSSTKRLTICGTLDYLPPEMIESNEHDYTVDIWSLGILCYEFLVGKPPFEE 349 Query: 368 LKAGTKKQKYDKISEK 415 + + ++ K+ K Sbjct: 350 IDKNSTYKRIAKVDLK 365
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 47.8 bits (112), Expect = 2e-05 Identities = 47/181 (25%), Positives = 81/181 (44%), Gaps = 2/181 (1%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 ++C ++ V + Q++ + Y H++ LHRD+KP N L+ + ++ + D+GLA Sbjct: 208 DHCGNLMNMHNVKIFMFQLLRGLAYCHRRKILHRDLKPQNLLI---NERGELKLADFGLA 264 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLG-VEQSRRDDLESLGYVLMYFLRGSLP 358 + K +P + N T Y + LG E S D+ +G +L G Sbjct: 265 RA-------KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPL 317 Query: 359 WQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPS-EFISYFHYCRSLRFEDKPDYSYLKR 535 + G T K++ I + + TP E +S+P IS F R+ +P S+ R Sbjct: 318 FPG---STVKEELHLIF-RLLGTPTE---ESWPGVTSISEFRAYNFPRYLPQPLLSHAPR 370 Query: 536 L 538 L Sbjct: 371 L 371
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 47.8 bits (112), Expect = 2e-05 Identities = 38/120 (31%), Positives = 56/120 (46%), Gaps = 5/120 (4%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+ + + Y+H + HRDIKP+NFL + + IID+GLA F TH + E Sbjct: 221 QIFSVLNYLHIRNICHRDIKPENFLFYDMTPESLIKIIDFGLASYF----THNNY---EM 273 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG-----LKAGTKKQKY 397 K GT Y + G + + D+ S G + L G P+ G + + KK KY Sbjct: 274 KTKAGTPYYVAPQVLTG-SYNYKCDMWSSGVLFYILLCGYPPFFGESDHEILSMVKKGKY 332
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/110 (30%), Positives = 50/110 (45%) Frame = +2 Query: 38 LMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHI 217 L + +Q + + +H+ +HRDIKP N L+ V I D+G+AK + Sbjct: 126 LDVMEQAAHGLSVIHRMDMVHRDIKPGNMLITAN---GIVKITDFGIAK------AAAAV 176 Query: 218 PYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 P + GTA+Y S G E + D+ SLG V + G P+ G Sbjct: 177 PLTRTGMVVGTAQYVSPEQAQGKEVTAASDIYSLGVVGYEMMAGRRPFTG 226
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 47.8 bits (112), Expect = 2e-05 Identities = 32/114 (28%), Positives = 52/114 (45%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 FS++ L + + ++ + H+ G +HRDIKP+N L+ V I D+GLAK Sbjct: 112 FSVRETLRVVAETLDGLASAHRAGVVHRDIKPENILI---NDRGHVQITDFGLAK----- 163 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 L GTA Y + + + + DL S+G + L G +P+ Sbjct: 164 -AASQATLSSTGMLLGTAAYLAPEMIENNQATAQGDLYSVGIMAWEMLTGKVPF 216
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 47.4 bits (111), Expect = 3e-05 Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 1/104 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q++ V Y H HRD+KP+N L L +K ++ I D+G+A +P + Sbjct: 222 QIVEGVSYCHSFNICHRDLKPENLL--LDKKNRRIKIADFGMAA--------LELPNKLL 271 Query: 233 KNLTGTARYASVNTHLG-VEQSRRDDLESLGYVLMYFLRGSLPW 361 K G+ YAS +G D+ S G VL L G LP+ Sbjct: 272 KTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPF 315
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 47.4 bits (111), Expect = 3e-05 Identities = 32/134 (23%), Positives = 60/134 (44%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F K V L Q++ V ++H + +H D+KP N L+ + I+D+GL++ ++ Sbjct: 158 FKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNS 217 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG 379 + E + + GT Y + S D+ S+G + L G P+ G Sbjct: 218 E--------ELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLG---N 266 Query: 380 TKKQKYDKISEKKM 421 K++ + IS+ + Sbjct: 267 DKQETFLNISQMNL 280
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 47.4 bits (111), Expect = 3e-05 Identities = 47/181 (25%), Positives = 80/181 (44%), Gaps = 2/181 (1%) Frame = +2 Query: 2 NYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLA 181 ++C ++ V + Q++ + Y H + LHRD+KP N L+ + ++ + D+GLA Sbjct: 208 DHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLI---NERGELKLADFGLA 264 Query: 182 KKFRDLQTHKHIPYRENKNLTGTARYASVNTHLG-VEQSRRDDLESLGYVLMYFLRGSLP 358 + K +P + N T Y + LG E S D+ +G +L G Sbjct: 265 RA-------KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPL 317 Query: 359 WQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPS-EFISYFHYCRSLRFEDKPDYSYLKR 535 + G T K++ I + + TP E +S+P IS F R+ +P S+ R Sbjct: 318 FPG---STVKEELHLIF-RLLGTPTE---ESWPGVTSISEFRAYNFPRYLPQPLLSHAPR 370 Query: 536 L 538 L Sbjct: 371 L 371
>MAST3_HUMAN (O60307) Microtubule-associated serine/threonine-protein kinase 3| (EC 2.7.11.1) Length = 1309 Score = 47.4 bits (111), Expect = 3e-05 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 8/148 (5%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK-K 187 +R + +TVL L EY+H G +HRD+KPDN L+ + + D+GL+K Sbjct: 467 ARLYFAETVLAL--------EYLHNYGIVHRDLKPDNLLI---TSLGHIKLTDFGLSKIG 515 Query: 188 FRDLQTHKHIPYRE-------NKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR 346 + T+ + + E +K + GT Y + + D ++G VL FL Sbjct: 516 LMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLV 575 Query: 347 GSLPWQGLKAGTKKQKYDKISEKKMLTP 430 G +P+ G T ++ + ++ +++ P Sbjct: 576 GCVPFFG---DTPEELFGQVVSDEIMWP 600
>E2AK3_HUMAN (Q9NZJ5) Eukaryotic translation initiation factor 2-alpha kinase 3| precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) Length = 1115 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/144 (23%), Positives = 61/144 (42%), Gaps = 5/144 (3%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHI----- 217 Q+ VE++H KG +HRD+KP N + + V + D+GL + + + Sbjct: 919 QIAEAVEFLHSKGLMHRDLKPSNIFFTMD---DVVKVGDFGLVTAMDQDEEEQTVLTPMP 975 Query: 218 PYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKY 397 Y + GT Y S G S + D+ SLG +L L T+ ++ Sbjct: 976 AYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL--------YPFSTQMERV 1027 Query: 398 DKISEKKMLTPVEVLCKSYPSEFI 469 +++ + L + + YP E++ Sbjct: 1028 RTLTDVRNLKFPPLFTQKYPCEYV 1051
>MKNK1_BOVIN (Q58D94) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 420 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/105 (32%), Positives = 46/105 (43%), Gaps = 5/105 (4%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 +++ H KG HRD+KP+N L K + V I D+ L + + I E G Sbjct: 146 LDFRHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCG 205 Query: 248 TARY-----ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 +A Y V T +R DL SLG VL L G P+ G Sbjct: 206 SAEYMAPEVVEVFTDEATFYDKRCDLWSLGVVLYIMLSGYPPFVG 250
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 47.4 bits (111), Expect = 3e-05 Identities = 40/187 (21%), Positives = 77/187 (41%), Gaps = 2/187 (1%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQ--KGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 +++++ + A Q + Y+H + +HRDIKP N L L + + I D+GLA Sbjct: 102 EYTVEQAVRWALQCAKALAYLHSLDRPIVHRDIKPQNML--LYNQHEDLKICDFGLATDM 159 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 + +T ++ GT RY + ++ + + D+ S G +L + LP+ L Sbjct: 160 SNNKT----------DMQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMTRQLPYSHL 209 Query: 371 KAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDL 550 + + K P+E + P C + E +P +++ Sbjct: 210 ENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEKRPSMKEIEK----- 264 Query: 551 FIREGYQ 571 F+ E Y+ Sbjct: 265 FLGEQYE 271
>MKNK2_XENLA (Q6P431) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 467 Score = 47.4 bits (111), Expect = 3e-05 Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 5/123 (4%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 R F+ + + + + Y+H KG HRD+KP+N L + + V I D+ L + Sbjct: 174 RHFNEREASFVVRDIAEALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIK 233 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQ-----SRRDDLESLGYVLMYFLRGSLP 358 I E G+A Y + + +R DL SLG +L L G P Sbjct: 234 LNSDCSPISTPELLTPCGSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPP 293 Query: 359 WQG 367 + G Sbjct: 294 FVG 296
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 47.4 bits (111), Expect = 3e-05 Identities = 28/100 (28%), Positives = 49/100 (49%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 +E++H G ++RD+KP+N L+ + + D+GL+K+ D + ++ + G Sbjct: 217 LEHLHSLGIVYRDLKPENILLDAD---GHIKVTDFGLSKEAIDSE-------KKTYSFCG 266 Query: 248 TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 T Y + S D SLG ++ L G LP+QG Sbjct: 267 TVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQG 306 Score = 40.4 bits (93), Expect = 0.004 Identities = 36/137 (26%), Positives = 58/137 (42%), Gaps = 4/137 (2%) Frame = +2 Query: 23 SLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGL-GRKANQVYIIDYGLAKKFRDL 199 S K V + ++N V+Y+H + HRD+ N L L + + I+D+G AK+ R Sbjct: 545 SEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSR-- 602 Query: 200 QTHKHIPYRENKNLTG---TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 EN L TA++ + R D+ SLG +L L G P+ Sbjct: 603 --------AENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMG 654 Query: 371 KAGTKKQKYDKISEKKM 421 T Q ++ + K+ Sbjct: 655 PNDTPDQILQRVGDGKI 671
>PRKX_MOUSE (Q922R0) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (PKA-related protein kinase) Length = 355 Score = 47.4 bits (111), Expect = 3e-05 Identities = 30/115 (26%), Positives = 51/115 (44%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 +FS + A +++ +EY+H K ++RD+KP+N L+ + + + D+G AKK D Sbjct: 140 RFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLD---REGHIKLTDFGFAKKLVD 196 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 L GT Y + R D +LG ++ L G P+ Sbjct: 197 ----------RTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPF 241
>MKNK2_XENTR (Q66I46) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 466 Score = 47.4 bits (111), Expect = 3e-05 Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 5/123 (4%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 R F+ + + + + Y+H KG HRD+KP+N L + + V I D+ L + Sbjct: 174 RHFNEREASFVVRDIAEALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIK 233 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQ-----SRRDDLESLGYVLMYFLRGSLP 358 I E G+A Y + + +R DL SLG +L L G P Sbjct: 234 LNSDCSPISTPELLTPCGSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPP 293 Query: 359 WQG 367 + G Sbjct: 294 FVG 296
>KS6B1_RAT (P67999) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/119 (28%), Positives = 56/119 (47%) Frame = +2 Query: 74 YMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTA 253 ++HQKG ++RD+KP+N ++ V + D+GL K+ T H GT Sbjct: 208 HLHQKGIIYRDLKPENIML---NHQGHVKLTDFGLCKESIHDGTVTH-------TFCGTI 257 Query: 254 RYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTP 430 Y + + +R D SLG ++ L G+ P+ G +K+ DKI + K+ P Sbjct: 258 EYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTG---ENRKKTIDKILKCKLNLP 313
>KS6B1_RABIT (P67998) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/119 (28%), Positives = 56/119 (47%) Frame = +2 Query: 74 YMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTA 253 ++HQKG ++RD+KP+N ++ V + D+GL K+ T H GT Sbjct: 208 HLHQKGIIYRDLKPENIML---NHQGHVKLTDFGLCKESIHDGTVTH-------TFCGTI 257 Query: 254 RYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTP 430 Y + + +R D SLG ++ L G+ P+ G +K+ DKI + K+ P Sbjct: 258 EYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTG---ENRKKTIDKILKCKLNLP 313
>KS6B1_MOUSE (Q8BSK8) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/119 (28%), Positives = 56/119 (47%) Frame = +2 Query: 74 YMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTA 253 ++HQKG ++RD+KP+N ++ V + D+GL K+ T H GT Sbjct: 208 HLHQKGIIYRDLKPENIML---NHQGHVKLTDFGLCKESIHDGTVTH-------TFCGTI 257 Query: 254 RYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTP 430 Y + + +R D SLG ++ L G+ P+ G +K+ DKI + K+ P Sbjct: 258 EYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTG---ENRKKTIDKILKCKLNLP 313
>KS6B1_HUMAN (P23443) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (p70-alpha) Length = 525 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/119 (28%), Positives = 56/119 (47%) Frame = +2 Query: 74 YMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTA 253 ++HQKG ++RD+KP+N ++ V + D+GL K+ T H GT Sbjct: 208 HLHQKGIIYRDLKPENIML---NHQGHVKLTDFGLCKESIHDGTVTH-------TFCGTI 257 Query: 254 RYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTP 430 Y + + +R D SLG ++ L G+ P+ G +K+ DKI + K+ P Sbjct: 258 EYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTG---ENRKKTIDKILKCKLNLP 313
>RK_BOVIN (P28327) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 561 Score = 47.4 bits (111), Expect = 3e-05 Identities = 44/167 (26%), Positives = 76/167 (45%), Gaps = 2/167 (1%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+++ +E++HQ+ ++RD+KP+N L+ V I D GLA + + QT + Sbjct: 297 QIVSGLEHLHQRNIIYRDLKPENVLLD---DDGNVRISDLGLAVELKAGQT-------KT 346 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISE 412 K GT + + LG E D +LG L + P+ + + +K+ Sbjct: 347 KGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPF--------RARGEKVEN 398 Query: 413 KKMLTPVEVLCKSYPSEFI-SYFHYCRSLRFEDKPDYSYLKRL-FRD 547 K++ V +YP +F + +C +L +D KRL FRD Sbjct: 399 KELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPE-----KRLGFRD 440
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 47.4 bits (111), Expect = 3e-05 Identities = 35/140 (25%), Positives = 63/140 (45%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 S++F A ++I +EY+H ++RD+KP+N L+ + + I D+G AK+ Sbjct: 162 SQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLD---RNGHIKITDFGFAKEV 218 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 + + L GT Y + ++ D SLG ++ L G P+ Sbjct: 219 QTV----------TWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDT 268 Query: 371 KAGTKKQKYDKISEKKMLTP 430 T + Y+KI + K++ P Sbjct: 269 ---TPMKTYEKILQGKVVYP 285
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 47.0 bits (110), Expect = 4e-05 Identities = 34/117 (29%), Positives = 54/117 (46%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 + FS + ++++ V +MH G +HRD+KP+N L ++ IID+G A+ Sbjct: 514 KHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFAR--- 570 Query: 194 DLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 L+ + P K T YA+ DL SLG +L L G +P+Q Sbjct: 571 -LKPPDNQPL---KTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQ 623 Score = 41.2 bits (95), Expect = 0.002 Identities = 29/117 (24%), Positives = 58/117 (49%), Gaps = 2/117 (1%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 +F+ V + +++ +E++H+ G ++RDIK +N L+ V + D+GL+K+F Sbjct: 148 RFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD---SNGHVVLTDFGLSKEFVA 204 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVE--QSRRDDLESLGYVLMYFLRGSLPW 361 +T + + GT Y + + G + + D SLG ++ L G+ P+ Sbjct: 205 DETERAYSF------CGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF 255
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 47.0 bits (110), Expect = 4e-05 Identities = 31/115 (26%), Positives = 54/115 (46%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 KF+ +T A ++++ +EY+H ++RD+KP+N L+ + + I D+G AKK RD Sbjct: 368 KFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLI---NRDGHLKITDFGFAKKLRD 424 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 L GT Y + ++ D +LG ++ L G P+ Sbjct: 425 ----------RTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPF 469
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 47.0 bits (110), Expect = 4e-05 Identities = 31/103 (30%), Positives = 48/103 (46%) Frame = +2 Query: 35 VLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKH 214 +L L +Q++ VEY+H KG +HRD+KP N + R + I D+GLA + Sbjct: 353 ILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDER---HIKIGDFGLATALEN------ 403 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFL 343 + TGT +Y S + D+ +LG +L L Sbjct: 404 -DGKSRTRRTGTLQYMSPEQLFLKHYGKEVDIFALGLILAELL 445
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 47.0 bits (110), Expect = 4e-05 Identities = 29/116 (25%), Positives = 58/116 (50%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F+ + V ++ ++++HQ G ++RD+KP+N L+ + + + D+GL+K+ D Sbjct: 170 FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD---EIGHIKLTDFGLSKESVDQ 226 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 + ++ + GT Y + S+ D S G ++ L G+LP+QG Sbjct: 227 E-------KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQG 275 Score = 42.0 bits (97), Expect = 0.001 Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 1/43 (2%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFL-MGLGRKANQVYIIDYGLAKKFR 193 V+Y+H +G +HRD+KP N L M A+ + I D+G AK+ R Sbjct: 531 VDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLR 573
>CHK2_CAEEL (Q9U1Y5) Serine/threonine-protein kinase chk-2 (EC 2.7.11.1)| (Ce-cds-1) (Ce-chk-2) Length = 476 Score = 47.0 bits (110), Expect = 4e-05 Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 2/107 (1%) Frame = +2 Query: 47 ADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYR 226 A Q+I+ + Y+H G HRDIKP+N L + + + D+G+AK Sbjct: 282 AFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKN----------SVN 331 Query: 227 ENKNLTGTARY--ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 K GT Y + + GVE + + D+ SLG VL G P+ Sbjct: 332 RMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPF 378
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 47.0 bits (110), Expect = 4e-05 Identities = 34/143 (23%), Positives = 61/143 (42%) Frame = +2 Query: 11 SRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF 190 S K + + +++ + + Y H K +HRDIKP+N L+G +V I D+G + Sbjct: 135 SEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF---RGEVKIADFGWS--- 188 Query: 191 RDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGL 370 H P K + GT Y G + DL +G + L G P++ Sbjct: 189 ------VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE-- 240 Query: 371 KAGTKKQKYDKISEKKMLTPVEV 439 + + + Y +I + + P+ + Sbjct: 241 -SASHSETYRRILKVDVRFPLSM 262
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 47.0 bits (110), Expect = 4e-05 Identities = 27/96 (28%), Positives = 46/96 (47%) Frame = +2 Query: 80 HQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARY 259 H+ G +HRD+KP N ++ V ++D+G+A+ D + + + GTA+Y Sbjct: 128 HEAGIIHRDVKPANIMI---NNTGGVKVMDFGIARALDDSTS----AMTQTAAVIGTAQY 180 Query: 260 ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 S G R D+ + G VL + G P++G Sbjct: 181 LSPEQARGKPADARSDVYAAGCVLYELVTGRPPFEG 216
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 47.0 bits (110), Expect = 4e-05 Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 4/109 (3%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF---RDLQTHKHIPY 223 Q+++ V Y HQK +HRD+K +N L L +AN + I D+G + +F L T Sbjct: 164 QIVSAVHYCHQKNIVHRDLKAENLL--LDAEAN-IKIADFGFSNEFTLGSKLDT------ 214 Query: 224 RENKNLTGTARYASVNTHLGVEQSRRD-DLESLGYVLMYFLRGSLPWQG 367 G+ YA+ G + + D+ SLG +L + GSLP+ G Sbjct: 215 -----FCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDG 258
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 47.0 bits (110), Expect = 4e-05 Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 4/109 (3%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKF---RDLQTHKHIPY 223 Q+++ V Y HQK +HRD+K +N L L +AN + I D+G + +F L T Sbjct: 164 QIVSAVHYCHQKNIVHRDLKAENLL--LDAEAN-IKIADFGFSNEFTLGSKLDT------ 214 Query: 224 RENKNLTGTARYASVNTHLGVEQSRRD-DLESLGYVLMYFLRGSLPWQG 367 G+ YA+ G + + D+ SLG +L + GSLP+ G Sbjct: 215 -----FCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDG 258
>RK_MOUSE (Q9WVL4) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 47.0 bits (110), Expect = 4e-05 Identities = 53/180 (29%), Positives = 80/180 (44%), Gaps = 4/180 (2%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 FS + Q+I+ +E++HQ+ ++RD+KP+N L+ + I D GLA + ++ Sbjct: 289 FSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLD---NDGNIRISDLGLAVELKEG 345 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVL--MYFLRGSLPWQGLK 373 Q + K GT + + G E D +LG L M RG +G K Sbjct: 346 Q-------NKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPFRARGEK 398 Query: 374 AGTKKQKYDKISEKKMLTPVEVLCKSYPSEFI-SYFHYCRSLRFEDKPDYSYLKRL-FRD 547 K+ K ISE PV+ YP +F + +C L E P+ KRL FRD Sbjct: 399 VENKELKQRIISE-----PVK-----YPEKFSQASKDFCEQL-LEKDPE----KRLGFRD 443
>RK_HUMAN (Q15835) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 563 Score = 47.0 bits (110), Expect = 4e-05 Identities = 54/174 (31%), Positives = 79/174 (45%), Gaps = 4/174 (2%) Frame = +2 Query: 38 LMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHI 217 L Q+I +E++HQ+ ++RD+KP+N L+ V I D GLA + D Q+ Sbjct: 295 LFYTAQIICGLEHLHQRRIVYRDLKPENVLLD---NDGNVRISDLGLAVELLDGQS---- 347 Query: 218 PYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVL--MYFLRGSLPWQGLKAGTKKQ 391 + K GT + + G E D +LG L M RG +G K K+ Sbjct: 348 ---KTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKEL 404 Query: 392 KYDKISEKKMLTPVEVLCKSYPSEFI-SYFHYCRSLRFEDKPDYSYLKRL-FRD 547 K+ ISE PV+ YP +F + +C +L E P+ KRL FRD Sbjct: 405 KHRIISE-----PVK-----YPDKFSQASKDFCEAL-LEKDPE----KRLGFRD 443
>KC61_SCHPO (Q9UU87) Probable serine/threonine-protein kinase C1919.01 (EC| 2.7.11.1) Length = 354 Score = 47.0 bits (110), Expect = 4e-05 Identities = 21/44 (47%), Positives = 31/44 (70%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAK 184 Q++ V Y+H KG +HRDIKPDN L ++ N + +ID+GLA+ Sbjct: 183 QLVLAVNYIHGKGVIHRDIKPDNILF---KENNNLCVIDFGLAE 223
>PKN1_CORGL (Q8NU98) Probable serine/threonine protein kinase pknB (EC| 2.7.11.1) Length = 646 Score = 46.6 bits (109), Expect = 5e-05 Identities = 26/96 (27%), Positives = 45/96 (46%) Frame = +2 Query: 80 HQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTGTARY 259 H G +HRD+KP N ++ V ++D+G+A+ D + + + GTA+Y Sbjct: 128 HDAGIIHRDVKPANIMI---TNTGGVKVMDFGIARAVNDSTS----AMTQTSAVIGTAQY 180 Query: 260 ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 S G R D+ + G V+ + G P++G Sbjct: 181 LSPEQARGKPADARSDIYATGCVMYELVTGKPPFEG 216
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 46.6 bits (109), Expect = 5e-05 Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 6/86 (6%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 FS + Q++ +EY H+K FLHRDIK N L+ + Q+ + D+GLA+ + Sbjct: 831 FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILL---NNSGQIKLADFGLARLYNSE 887 Query: 200 QTHKH------IPYRENKNLTGTARY 259 ++ + + YR + L G RY Sbjct: 888 ESRPYTNKVITLWYRPPELLLGEERY 913
>MYLK_RABIT (P29294) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1147 Score = 46.6 bits (109), Expect = 5e-05 Identities = 28/105 (26%), Positives = 53/105 (50%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+ VEY+H++G +H D+KP+N +M + + ++ +ID+GLA++ + + Sbjct: 800 QISEGVEYIHKQGIVHLDLKPEN-IMCVNKTGTRIKLIDFGLARRLENAGS--------L 850 Query: 233 KNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 K L GT + + S D+ S+G + + G P+ G Sbjct: 851 KVLFGTPEFVAPEVINYEPISYATDMWSIGVICYILVSGLSPFMG 895
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 46.6 bits (109), Expect = 5e-05 Identities = 39/138 (28%), Positives = 63/138 (45%), Gaps = 9/138 (6%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQ-THKHIPYRE 229 QM + Y+H KG +HRD+K +N L+ K V I D+G AK Q H YR+ Sbjct: 131 QMALGIAYLHSKGIVHRDLKLENLLLD---KRENVKISDFGFAKMVPSSQPVHSSPSYRQ 187 Query: 230 NKNLT-------GTARYASVNTHLGVEQSR-RDDLESLGYVLMYFLRGSLPWQGLKAGTK 385 +L+ G+ YA LG+ + D S+G +L + LP+ T Sbjct: 188 MNSLSHLSQTYCGSFAYACPEILLGLPYNPFLSDTWSMGVILYTLVVARLPFD----DTN 243 Query: 386 KQKYDKISEKKMLTPVEV 439 +K + ++K++ P + Sbjct: 244 LKKLLRETQKEVTFPANL 261
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 46.6 bits (109), Expect = 5e-05 Identities = 29/115 (25%), Positives = 53/115 (46%) Frame = +2 Query: 20 FSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDL 199 F+ + + +++ V+Y+H G HRD+KP+N L +++ I D+GLA Sbjct: 188 FTERDATRVLQMVLDGVKYLHTLGITHRDLKPENLLYYHPGADSKIMITDFGLA------ 241 Query: 200 QTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQ 364 T K K GT Y + + + D+ +LG + L G++P++ Sbjct: 242 STRKKGDECLMKTTCGTPEYIAPEILVRKPYTNAVDMWALGVISYILLSGTMPFE 296
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 46.6 bits (109), Expect = 5e-05 Identities = 26/98 (26%), Positives = 44/98 (44%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 V+Y+H G +HRD+KP+N L + + I D+GL+ + D Q Y G Sbjct: 142 VKYLHDNGIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQ------YYMLMTACG 195 Query: 248 TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPW 361 T Y + + D+ ++G + + L G P+ Sbjct: 196 TPEYMAPEVFRRTGYGKPVDMWAIGVITYFLLSGYTPF 233
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 46.6 bits (109), Expect = 5e-05 Identities = 29/100 (29%), Positives = 50/100 (50%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYRENKNLTG 247 ++++H G ++RD+KP+N L+ + + + D+GL+K+ D H+ Y + G Sbjct: 175 LDHLHSLGIIYRDLKPENILLD---EEGHIKLTDFGLSKEAID---HEKKAY----SFCG 224 Query: 248 TARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQG 367 T Y + S D S G ++ L GSLP+QG Sbjct: 225 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQG 264 Score = 36.2 bits (82), Expect = 0.074 Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Frame = +2 Query: 68 VEYMHQKGFLHRDIKPDNFL-MGLGRKANQVYIIDYGLAKKFR 193 VE +H +G +HRD+KP N L + + I D+G AK+ R Sbjct: 521 VENLHSQGVVHRDLKPSNILYVDESGDPESIRICDFGFAKQLR 563
>E2AK1_RAT (Q63185) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2- Length = 620 Score = 46.6 bits (109), Expect = 5e-05 Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 6/100 (6%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDN-FLMGLGRKANQVYIIDYGLA-----KKFRDLQTHKH 214 +++ V Y+H G +HRD+KP N FL G QV I D+GLA +K D Sbjct: 423 ELVEGVFYIHNMGIVHRDLKPRNIFLHG---PDQQVKIGDFGLACADIIQKSADWTNRNG 479 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLM 334 + + GT YAS G E + D+ SLG +L+ Sbjct: 480 KGTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILL 519
>E2AK1_HUMAN (Q9BQI3) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor Length = 630 Score = 46.6 bits (109), Expect = 5e-05 Identities = 35/100 (35%), Positives = 48/100 (48%), Gaps = 6/100 (6%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDN-FLMGLGRKANQVYIIDYGLA-----KKFRDLQTHKH 214 +++ V Y+H G +HRD+KP N FL G QV I D+GLA +K D Sbjct: 425 ELVEGVFYIHNMGIVHRDLKPRNIFLHG---PDQQVKIGDFGLACTDILQKNTDWTNRNG 481 Query: 215 IPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLM 334 + + GT YAS G E + D+ SLG VL+ Sbjct: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLL 521
>MKNK1_MOUSE (O08605) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 427 Score = 46.6 bits (109), Expect = 5e-05 Identities = 34/123 (27%), Positives = 52/123 (42%), Gaps = 5/123 (4%) Frame = +2 Query: 14 RKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFR 193 + F+ + + + ++++H KG HRD+KP+N L K + V I D+ L + Sbjct: 140 KHFNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVK 199 Query: 194 DLQTHKHIPYRENKNLTGTARY-----ASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLP 358 + I E G+A Y V +R DL SLG VL L G P Sbjct: 200 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPP 259 Query: 359 WQG 367 + G Sbjct: 260 FVG 262
>CHK1_CAEBR (Q61RA2) Serine/threonine-protein kinase chk-1 (EC 2.7.11.1)| Length = 493 Score = 46.6 bits (109), Expect = 5e-05 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 1/104 (0%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYREN 232 Q+I ++Y+H +HRDIKP+N L+ ++ + I D+G+A +R+ + + Sbjct: 133 QLIEGLKYIHDCDIVHRDIKPENLLL---TTSHVLKISDFGMATLYRNEGKERLLDLS-- 187 Query: 233 KNLTGTARYASVNTHLGVE-QSRRDDLESLGYVLMYFLRGSLPW 361 GT YA+ G + + D+ S G VL+ L G LPW Sbjct: 188 ---CGTIPYAAPEVCAGGKYRGPPIDVWSSGIVLIAMLTGELPW 228
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 46.6 bits (109), Expect = 5e-05 Identities = 39/182 (21%), Positives = 76/182 (41%), Gaps = 16/182 (8%) Frame = +2 Query: 17 KFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRD 196 + S + + +A+ ++ + Y+H++ +HRDIKP N L+ + ++ + D+G++ + + Sbjct: 313 RISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILL---NEKGEIKLCDFGVSGEAVN 369 Query: 197 LQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 376 TGT+ Y + G S D+ SLG L+ G P++ Sbjct: 370 SLA---------MTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFES--- 417 Query: 377 GTKKQKYDKISEKKMLTPVEVLCK----------------SYPSEFISYFHYCRSLRFED 508 DKI++ + P+E+L S+ F S+ YC + Sbjct: 418 -------DKITQN--VAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARE 468 Query: 509 KP 514 +P Sbjct: 469 RP 470
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 6/109 (5%) Frame = +2 Query: 53 QMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKFRDLQTHKHIPYR-- 226 Q++ + Y+H + LHRDIKP N L+ + D+G A + T + Y Sbjct: 1144 QLLEGLAYIHSQHILHRDIKPANILLD---HRGMIKYSDFGSA-LYVSPPTDPEVRYEDI 1199 Query: 227 --ENKNLTGTARYASVNTHLGVEQS--RRDDLESLGYVLMYFLRGSLPW 361 E ++L GT Y + LG ++ D+ SLG V++ + GS PW Sbjct: 1200 QPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPW 1248 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 82,068,524 Number of Sequences: 219361 Number of extensions: 1700587 Number of successful extensions: 6439 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6097 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6236 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 5216272880 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
