ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags21l08 |
|---|---|
| Clone Library Name | barley_pub |
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 150 bits (378), Expect = 3e-36 Identities = 71/138 (51%), Positives = 101/138 (73%) Frame = +2 Query: 101 ESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEE 280 E ++ L+++ T+ AT +F+ NKLGQGGFG VYKG L DG+EIAVKRLSK+S QG +E Sbjct: 509 EELELPLIEMETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDE 568 Query: 281 LKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRH 460 NE+ L+A+L+H NLV+++G C+E E++L+YE++ N SLD LF + +L+W R Sbjct: 569 FMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRSKLNWNERF 628 Query: 461 RIIRGIARGLQYLHEDSQ 514 I G+ARGL YLH+DS+ Sbjct: 629 DITNGVARGLLYLHQDSR 646
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 118 bits (295), Expect = 1e-26 Identities = 64/150 (42%), Positives = 99/150 (66%), Gaps = 6/150 (4%) Frame = +2 Query: 71 PSYSTEGKDTESVDS--MLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVK 244 P S G + + V++ ML+ I LR+ T +F+ N LG GGFG VYKG L DG +IAVK Sbjct: 557 PGTSEVGDNIQMVEAGNMLISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVK 616 Query: 245 RLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 418 R+ + +G E K+E+A++ K++H++LV L+G CL+ E+LLVYE++P +L + LF Sbjct: 617 RMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLF 676 Query: 419 D-TEKG-EQLDWGMRHRIIRGIARGLQYLH 502 + +E+G + L W R + +ARG++YLH Sbjct: 677 EWSEEGLKPLLWKQRLTLALDVARGVEYLH 706
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 111 bits (278), Expect = 1e-24 Identities = 56/110 (50%), Positives = 77/110 (70%), Gaps = 1/110 (0%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 +G+GGFG+VY+GTL DG+E+AVK S +STQG E NEL L++ ++H+NLV L+G C E Sbjct: 602 IGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNE 661 Query: 356 QQERLLVYEFVPNRS-LDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +++LVY F+ N S LD++ + K + LDW R I G ARGL YLH Sbjct: 662 YDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLH 711
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 110 bits (275), Expect = 2e-24 Identities = 56/110 (50%), Positives = 77/110 (70%), Gaps = 1/110 (0%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 +G+GGFG+VY+GTL DG+E+AVK S +STQG E NEL L++ ++H+NLV L+G C E Sbjct: 601 IGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNE 660 Query: 356 QQERLLVYEFVPNRS-LDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +++LVY F+ N S LD++ + K + LDW R I G ARGL YLH Sbjct: 661 YDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLH 710
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 109 bits (272), Expect = 5e-24 Identities = 56/132 (42%), Positives = 82/132 (62%), Gaps = 3/132 (2%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 + S L AT F+ ++ +G GGFG V+K TL DG +A+K+L + S QG E E+ Sbjct: 826 LKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMET 885 Query: 302 VAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ---LDWGMRHRIIR 472 + K+KH+NLV L+G C +ERLLVYEF+ SL+++L GE+ L W R +I + Sbjct: 886 LGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAK 945 Query: 473 GIARGLQYLHED 508 G A+GL +LH + Sbjct: 946 GAAKGLCFLHHN 957
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 108 bits (271), Expect = 7e-24 Identities = 57/130 (43%), Positives = 78/130 (60%), Gaps = 1/130 (0%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 + + L AT F + +G GGFG VYK L DG +A+K+L S QG E E+ Sbjct: 871 LTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMET 930 Query: 302 VAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQLDWGMRHRIIRGI 478 + K+KH+NLV L+G C ERLLVYEF+ SL+ +L D +K G +L+W R +I G Sbjct: 931 IGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGS 990 Query: 479 ARGLQYLHED 508 ARGL +LH + Sbjct: 991 ARGLAFLHHN 1000
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 108 bits (270), Expect = 9e-24 Identities = 58/120 (48%), Positives = 77/120 (64%), Gaps = 1/120 (0%) Frame = +2 Query: 146 ATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKN 325 AT F++ N +G GGFG VYK LP + +AVK+LS++ TQG E E+ + K+KH N Sbjct: 913 ATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPN 972 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFD-TEKGEQLDWGMRHRIIRGIARGLQYLH 502 LV L+G C +E+LLVYE++ N SLD L + T E LDW R +I G ARGL +LH Sbjct: 973 LVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLH 1032
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 108 bits (269), Expect = 1e-23 Identities = 60/151 (39%), Positives = 87/151 (57%), Gaps = 10/151 (6%) Frame = +2 Query: 80 STEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLP----------DGE 229 S GK ES + + + L+ AT +F + LGQGGFG VY+G + G Sbjct: 60 SDSGKLLESPNLKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGM 119 Query: 230 EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 409 +A+KRL+ S QG E ++E+ + L H+NLV+L+G C E +E LLVYEF+P SL+ Sbjct: 120 IVAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLES 179 Query: 410 ILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 LF + + W +R +I+ G ARGL +LH Sbjct: 180 HLF--RRNDPFPWDLRIKIVIGAARGLAFLH 208
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 107 bits (268), Expect = 2e-23 Identities = 63/162 (38%), Positives = 90/162 (55%), Gaps = 2/162 (1%) Frame = +2 Query: 26 WRRRRRSPAQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVY 205 WRR++ + P + E + + L+ A+ +F+ N LG+GGFG VY Sbjct: 249 WRRKKPQDHFFDVP----AEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVY 304 Query: 206 KGTLPDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYE 382 KG L DG +AVKRL + TQG E + + E+ +++ H+NL+RL G C+ ERLLVY Sbjct: 305 KGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYP 364 Query: 383 FVPNRSLDQILFD-TEKGEQLDWGMRHRIIRGIARGLQYLHE 505 ++ N S+ L + E LDW R RI G ARGL YLH+ Sbjct: 365 YMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHD 406
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 107 bits (268), Expect = 2e-23 Identities = 54/132 (40%), Positives = 81/132 (61%), Gaps = 1/132 (0%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 + + + +T F ++N +G GGFG VYK TLPDG ++A+KRLS + Q E + E+ Sbjct: 731 LSLDDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVET 790 Query: 302 VAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKG-EQLDWGMRHRIIRGI 478 +++ +H NLV L+G C + ++LL+Y ++ N SLD L + G LDW R RI RG Sbjct: 791 LSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGA 850 Query: 479 ARGLQYLHEDSQ 514 A GL YLH+ + Sbjct: 851 AEGLAYLHQSCE 862
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 107 bits (266), Expect = 3e-23 Identities = 58/125 (46%), Positives = 79/125 (63%), Gaps = 2/125 (1%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLSKSSTQGVEELKNELALVAKL 313 L AAT +F LG+GGFG VYKG L G+ +AVK+L ++ QG E E+ +++ L Sbjct: 79 LAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLMLSLL 138 Query: 314 KHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKG-EQLDWGMRHRIIRGIARGL 490 H NLV L+G C + +RLLVYEF+P SL+ L D E LDW MR +I G A+GL Sbjct: 139 HHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGL 198 Query: 491 QYLHE 505 ++LH+ Sbjct: 199 EFLHD 203
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 107 bits (266), Expect = 3e-23 Identities = 65/174 (37%), Positives = 93/174 (53%), Gaps = 11/174 (6%) Frame = +2 Query: 17 LFIWRRRRRSPAQANQPYPSYSTEGKDTESVDSML----------MDISTLRAATGDFAE 166 L + R RRRS + S S K+ + S L + L +T F + Sbjct: 677 LIVLRARRRSGEVDPEIEESESMNRKELGEIGSKLVVLFQSNDKELSYDDLLDSTNSFDQ 736 Query: 167 SNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGV 346 +N +G GGFG VYK TLPDG+++A+K+LS Q E + E+ +++ +H NLV L G Sbjct: 737 ANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGF 796 Query: 347 CLEQQERLLVYEFVPNRSLDQILFDTEKGEQ-LDWGMRHRIIRGIARGLQYLHE 505 C + +RLL+Y ++ N SLD L + G L W R RI +G A+GL YLHE Sbjct: 797 CFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHE 850
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 107 bits (266), Expect = 3e-23 Identities = 56/130 (43%), Positives = 79/130 (60%), Gaps = 1/130 (0%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 + + L AT F + +G GGFG VYK L DG +A+K+L S QG E E+ Sbjct: 876 LTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMET 935 Query: 302 VAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQLDWGMRHRIIRGI 478 + K+KH+NLV L+G C +ERLLVYE++ SL+ +L D +K G +L+W R +I G Sbjct: 936 IGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGA 995 Query: 479 ARGLQYLHED 508 ARGL +LH + Sbjct: 996 ARGLAFLHHN 1005
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 107 bits (266), Expect = 3e-23 Identities = 56/130 (43%), Positives = 79/130 (60%), Gaps = 1/130 (0%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 + + L AT F + +G GGFG VYK L DG +A+K+L S QG E E+ Sbjct: 876 LTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMET 935 Query: 302 VAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQLDWGMRHRIIRGI 478 + K+KH+NLV L+G C +ERLLVYE++ SL+ +L D +K G +L+W R +I G Sbjct: 936 IGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGA 995 Query: 479 ARGLQYLHED 508 ARGL +LH + Sbjct: 996 ARGLAFLHHN 1005
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 105 bits (263), Expect = 6e-23 Identities = 54/125 (43%), Positives = 80/125 (64%), Gaps = 2/125 (1%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPDGEEI-AVKRLSKSSTQGVEELKNELALVAKL 313 L ATG+F LG+GGFG V+KGT+ +++ A+K+L ++ QG+ E E+ ++ Sbjct: 96 LAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVLTLSLA 155 Query: 314 KHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ-LDWGMRHRIIRGIARGL 490 H NLV+L+G C E +RLLVYE++P SL+ L G++ LDW R +I G ARGL Sbjct: 156 DHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGAARGL 215 Query: 491 QYLHE 505 +YLH+ Sbjct: 216 EYLHD 220
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 104 bits (260), Expect = 1e-22 Identities = 55/124 (44%), Positives = 76/124 (61%), Gaps = 2/124 (1%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLK 316 L AT F+ + +G GGFG VYK L DG +A+K+L + + QG E E+ + K+K Sbjct: 851 LLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETIGKIK 910 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK--GEQLDWGMRHRIIRGIARGL 490 H+NLV L+G C +ERLLVYE++ SL+ +L + K G LDW R +I G ARGL Sbjct: 911 HRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGL 970 Query: 491 QYLH 502 +LH Sbjct: 971 AFLH 974
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 103 bits (258), Expect = 2e-22 Identities = 61/166 (36%), Positives = 95/166 (57%), Gaps = 13/166 (7%) Frame = +2 Query: 44 SPAQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPD 223 S A + PS TEG+ +S + + L++AT +F + LG+GGFG V+KG + + Sbjct: 30 SKASSVSVRPSPRTEGEILQSPNLKSFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDE 89 Query: 224 ----------GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLL 373 G IAVK+L++ QG +E E+ + + H++LV+L+G CLE + RLL Sbjct: 90 KSLTASRPGTGLVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLL 149 Query: 374 VYEFVPNRSLDQILFDTEKG---EQLDWGMRHRIIRGIARGLQYLH 502 VYEF+P SL+ LF +G + L W +R ++ G A+GL +LH Sbjct: 150 VYEFMPRGSLENHLF--RRGLYFQPLSWKLRLKVALGAAKGLAFLH 193
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 103 bits (256), Expect = 4e-22 Identities = 59/153 (38%), Positives = 90/153 (58%), Gaps = 13/153 (8%) Frame = +2 Query: 83 TEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPD----------GEE 232 TEG+ +S + + L+AAT +F + LG+GGFG+V+KG + + G Sbjct: 44 TEGEILQSPNLKSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVV 103 Query: 233 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 412 IAVK+L++ QG +E E+ + + H NLV+L+G CLE + RLLVYEF+P SL+ Sbjct: 104 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENH 163 Query: 413 LFDTEKG---EQLDWGMRHRIIRGIARGLQYLH 502 LF +G + L W +R ++ G A+GL +LH Sbjct: 164 LF--RRGSYFQPLSWTLRLKVALGAAKGLAFLH 194
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 102 bits (254), Expect = 6e-22 Identities = 60/153 (39%), Positives = 89/153 (58%), Gaps = 13/153 (8%) Frame = +2 Query: 83 TEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPD----------GEE 232 TEG+ ++ + +S L++AT +F + +G+GGFG V+KG + + G Sbjct: 43 TEGEILQNANLKNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIV 102 Query: 233 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 412 IAVKRL++ QG E E+ + +L H NLV+L+G CLE++ RLLVYEF+ SL+ Sbjct: 103 IAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENH 162 Query: 413 LFDTEKG---EQLDWGMRHRIIRGIARGLQYLH 502 LF +G + L W R R+ G ARGL +LH Sbjct: 163 LF--RRGTFYQPLSWNTRVRMALGAARGLAFLH 193
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 100 bits (250), Expect = 2e-21 Identities = 53/125 (42%), Positives = 74/125 (59%), Gaps = 3/125 (2%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLK 316 L AT F+ +G GGFG VYK L DG +A+K+L + + QG E E+ + K+K Sbjct: 852 LLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIK 911 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK---GEQLDWGMRHRIIRGIARG 487 H+NLV L+G C +ERLLVYE++ SL+ +L + G L+W R +I G ARG Sbjct: 912 HRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARG 971 Query: 488 LQYLH 502 L +LH Sbjct: 972 LAFLH 976
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 97.4 bits (241), Expect = 2e-20 Identities = 55/126 (43%), Positives = 79/126 (62%), Gaps = 4/126 (3%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSST--QGVEELKNELALVAK 310 L ATG F+E +++G+G F V+KG L DG +AVKR K+S + +E NEL L+++ Sbjct: 498 LEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSR 557 Query: 311 LKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF--DTEKGEQLDWGMRHRIIRGIAR 484 L H +L+ L+G C + ERLLVYEF+ + SL Q L D ++L+W R I AR Sbjct: 558 LNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAAR 617 Query: 485 GLQYLH 502 G++YLH Sbjct: 618 GIEYLH 623
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 94.7 bits (234), Expect = 1e-19 Identities = 51/112 (45%), Positives = 68/112 (60%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 +LG+G G VYKG L D +AVK+L ++ QG E + EL+++ ++ H NLVR+ G C Sbjct: 539 ELGRGESGTVYKGVLEDDRHVAVKKL-ENVRQGKEVFQAELSVIGRINHMNLVRIWGFCS 597 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 E RLLV E+V N SL ILF LDW R I G+A+GL YLH + Sbjct: 598 EGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAKGLAYLHHE 649
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 90.1 bits (222), Expect = 3e-18 Identities = 60/167 (35%), Positives = 88/167 (52%), Gaps = 12/167 (7%) Frame = +2 Query: 53 QANQPYPSYSTEGKDTESVDSMLMDIS--TLRAATGDFAE------SNKLGQGGFGAVYK 208 Q+ P S S E K E D+ S L+ T +F E NK+G+GGFG VYK Sbjct: 143 QSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYK 202 Query: 209 GTLPDGEEIAVKRLSKSSTQGVEELKN----ELALVAKLKHKNLVRLVGVCLEQQERLLV 376 G + + +AVK+L+ EELK E+ ++AK +H+NLV L+G + + LV Sbjct: 203 GYV-NNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLV 261 Query: 377 YEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 Y ++PN SL L + L W MR +I +G A G+ +LHE+ + Sbjct: 262 YVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 308
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 89.7 bits (221), Expect = 4e-18 Identities = 43/116 (37%), Positives = 73/116 (62%), Gaps = 1/116 (0%) Frame = +2 Query: 164 ESNKLGQGGFGAVYKGTLPDGEEIAVKRL-SKSSTQGVEELKNELALVAKLKHKNLVRLV 340 E N +G+GG G VY+G++P+ ++A+KRL + + + E+ + +++H+++VRL+ Sbjct: 694 EENIIGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLL 753 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 G + LL+YE++PN SL ++L + KG L W RHR+ A+GL YLH D Sbjct: 754 GYVANKDTNLLLYEYMPNGSLGELLHGS-KGGHLQWETRHRVAVEAAKGLCYLHHD 808
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 85.1 bits (209), Expect = 1e-16 Identities = 54/164 (32%), Positives = 86/164 (52%), Gaps = 12/164 (7%) Frame = +2 Query: 62 QPYPSYSTEGKDTESVDSMLMDIS--TLRAATGDFAES------NKLGQGGFGAVYKGTL 217 +P S S + + ES D+ S L++ T +F E N++G+GGFG VYKG + Sbjct: 146 EPPDSSSPDNRSVESSDTRFHSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCV 205 Query: 218 PDGEEIAVKRLSKSSTQGVEELKN----ELALVAKLKHKNLVRLVGVCLEQQERLLVYEF 385 + +AVK+L EELK E+ ++A +H+NLV L+G + LVY + Sbjct: 206 -NNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAY 264 Query: 386 VPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 +PN SL L + L W R ++ +G A G+++LHE+ + Sbjct: 265 MPNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHHI 308
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 84.3 bits (207), Expect = 2e-16 Identities = 45/109 (41%), Positives = 68/109 (62%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 +G+GGFG VY G + +GE++AVK LS+ S QG +E + E+ L+ ++ H NL LVG C E Sbjct: 580 IGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNE 638 Query: 356 QQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +L+YE++ N +L L ++ L W R +I A+GL+YLH Sbjct: 639 INHMVLIYEYMANENLGDYLAG-KRSFILSWEERLKISLDAAQGLEYLH 686
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 81.6 bits (200), Expect = 1e-15 Identities = 43/122 (35%), Positives = 68/122 (55%), Gaps = 1/122 (0%) Frame = +2 Query: 146 ATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQ-GVEELKNELALVAKLKHK 322 AT + + +G+G G +YK TL + AVK+L + + G + E+ + K++H+ Sbjct: 812 ATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRHR 871 Query: 323 NLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 NL++L L ++ L++Y ++ N SL IL +T + LDW RH I G A GL YLH Sbjct: 872 NLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAYLH 931 Query: 503 ED 508 D Sbjct: 932 FD 933
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 80.1 bits (196), Expect = 3e-15 Identities = 46/126 (36%), Positives = 70/126 (55%), Gaps = 5/126 (3%) Frame = +2 Query: 149 TGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSS----TQGVEELKNELALVAKLK 316 T +F+E ++G+GGFG VY+ + + AVKRL + + T + E+ +++ + Sbjct: 209 TCNFSEELRIGEGGFGCVYRAVMRN-TTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFR 267 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQILFDTEKGEQLDWGMRHRIIRGIARGLQ 493 H N+V G C E LVY F+PN SL DQ+ T+ L W R I+ G AR +Q Sbjct: 268 HPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQ 327 Query: 494 YLHEDS 511 +LH+DS Sbjct: 328 FLHQDS 333
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 79.3 bits (194), Expect = 6e-15 Identities = 50/126 (39%), Positives = 67/126 (53%), Gaps = 11/126 (8%) Frame = +2 Query: 164 ESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKN----------ELALVAKL 313 E N +G G G VYK L GE +AVK+L+KS G +E + E+ + + Sbjct: 685 EKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTI 744 Query: 314 KHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF-DTEKGEQLDWGMRHRIIRGIARGL 490 +HK++VRL C +LLVYE++PN SL +L D + G L W R RI A GL Sbjct: 745 RHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGL 804 Query: 491 QYLHED 508 YLH D Sbjct: 805 SYLHHD 810
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 78.2 bits (191), Expect = 1e-14 Identities = 52/163 (31%), Positives = 83/163 (50%), Gaps = 14/163 (8%) Frame = +2 Query: 65 PYPSYSTEGKDTESVDSMLMD---------ISTLRAATGDFAESNKLGQGGFGAVYKGTL 217 P P+ S+ ES S+L + + T +F+E K+G+GGFG VY+ + Sbjct: 172 PSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVM 231 Query: 218 PDGEEIAVKRLSKSS----TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEF 385 + AVKRL +++ T + E+ +++ +H N+V G C + LVY F Sbjct: 232 RN-TVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGF 290 Query: 386 VPNRSL-DQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDS 511 +PN SL D++ T+ L W R I+ G AR +Q+LH+DS Sbjct: 291 LPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDS 333
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 72.0 bits (175), Expect = 9e-13 Identities = 42/126 (33%), Positives = 70/126 (55%), Gaps = 2/126 (1%) Frame = +2 Query: 146 ATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKN 325 ATG E +G VYK L DG IA++ L + + + + + +++H+N Sbjct: 374 ATGQVMEKTS-----YGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHEN 428 Query: 326 LVRLVGVCLEQQ-ERLLVYEFVPNRSLDQILFDTE-KGEQLDWGMRHRIIRGIARGLQYL 499 LV L ++ E+LL+Y+++PN SL +L +++ + L+W RH+I GIARGL YL Sbjct: 429 LVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYL 488 Query: 500 HEDSQL 517 H ++ Sbjct: 489 HTGQEV 494
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 67.0 bits (162), Expect = 3e-11 Identities = 44/133 (33%), Positives = 73/133 (54%), Gaps = 3/133 (2%) Frame = +2 Query: 110 DSMLMDISTLRAATGDFAESNK-LGQGGFGAVYKGTLPDGEEIAVKRL-SKSSTQGVEEL 283 D L +S A ++ SN +G+GG G Y+ E +A+K L S SS + E Sbjct: 705 DVCLGGLSKNSPAAAKWSVSNTTMGRGGGGGGYESE--PYETVAIKTLKSGSSAKAKAEF 762 Query: 284 KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDT-EKGEQLDWGMRH 460 E ++ + H N++RL+GV + ++V E++ N SLDQ L +T ++GE++ W Sbjct: 763 LTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKIT 822 Query: 461 RIIRGIARGLQYL 499 ++ GIA G++YL Sbjct: 823 EMLYGIASGMKYL 835
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 66.6 bits (161), Expect = 4e-11 Identities = 42/138 (30%), Positives = 72/138 (52%) Frame = +2 Query: 89 GKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQ 268 G+ S +L + A DF + K+G G F VYK ++ V +++K + Sbjct: 34 GRGRPSSYRVLRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN 93 Query: 269 GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDW 448 L+ E+ L+ +L+H N++R +GVC+ Q + + E++ +L+Q+L E L W Sbjct: 94 RGNTLR-EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL---SSPEPLSW 149 Query: 449 GMRHRIIRGIARGLQYLH 502 +R + IARGL+YLH Sbjct: 150 PVRLHLALDIARGLRYLH 167
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 65.1 bits (157), Expect = 1e-10 Identities = 44/126 (34%), Positives = 68/126 (53%), Gaps = 7/126 (5%) Frame = +2 Query: 155 DFAE---SNKLGQGGFGAVYKGTLPDGEEIAVKRL----SKSSTQGVEELKNELALVAKL 313 DFAE +G GGFG VY+ G+E+AVK + +Q +E ++ E L A L Sbjct: 140 DFAELTLEEIIGIGGFGKVYRAFWI-GDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 198 Query: 314 KHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQ 493 KH N++ L GVCL++ LV EF L+++L G+++ + IARG+ Sbjct: 199 KHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMN 254 Query: 494 YLHEDS 511 YLH+++ Sbjct: 255 YLHDEA 260
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 65.1 bits (157), Expect = 1e-10 Identities = 38/120 (31%), Positives = 66/120 (55%) Frame = +2 Query: 143 AATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHK 322 A DF + K+G G F VYK ++ V +++K + L+ E+ L+ +L+H Sbjct: 47 ARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLR-EVQLMNRLRHP 105 Query: 323 NLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 N++R +GVC+ Q + + E++ +L+Q+L E L W +R + IA+GL+YLH Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL---SSPEPLSWPVRLHLALDIAQGLRYLH 162
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 65.1 bits (157), Expect = 1e-10 Identities = 38/120 (31%), Positives = 66/120 (55%) Frame = +2 Query: 143 AATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHK 322 A DF + K+G G F VYK ++ V +++K + L+ E+ L+ +L+H Sbjct: 47 ARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLR-EVQLMNRLRHP 105 Query: 323 NLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 N++R +GVC+ Q + + E++ +L+Q+L E L W +R + IA+GL+YLH Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL---SSPEPLSWPVRLHLALDIAQGLRYLH 162
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 64.3 bits (155), Expect = 2e-10 Identities = 36/117 (30%), Positives = 63/117 (53%), Gaps = 1/117 (0%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D KLG+G FG V+K T GE + +K L ++ + E+A++ L H++++ Sbjct: 400 DLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVL 459 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + +GV + ++ +V E+V L +++ D + L W R R+ R IA G+ YLH Sbjct: 460 KFIGVLYKDKKLHMVTEYVAGGCLKELIHD--PAQVLPWPQRVRLARDIACGMSYLH 514
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 63.9 bits (154), Expect = 2e-10 Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 16/170 (9%) Frame = +2 Query: 41 RSPAQANQPYPSYSTEGKD-----TESVDSML-MDISTLRAATGDFAESNKLGQGGFGAV 202 R+ A + PS + G + +S+L +D + L AT ++ N+LGQGGFG V Sbjct: 168 RTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDV 227 Query: 203 YKGTLPDGEEIAVKRL---SKSSTQGVEELK---NELALVAKLKHKNLVRLVGVCLEQQE 364 Y+G ++A+K + S + Q + EL+ NEL + ++H N++ L G ++ + Sbjct: 228 YRGKWKQ-LDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGK 286 Query: 365 RLLVYEFVPNRSLDQILFDTEKGEQ----LDWGMRHRIIRGIARGLQYLH 502 LVY+ + SL+ L K + L W R I G ARG+ +LH Sbjct: 287 PCLVYQLMKGGSLEARL-RAHKAQNPLPALTWQQRFSISLGTARGIYFLH 335
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 62.8 bits (151), Expect = 6e-10 Identities = 42/133 (31%), Positives = 63/133 (47%), Gaps = 21/133 (15%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQ----GVEELKNELALVAKLKHKNLVRLVG 343 +G GGFG VY+ T G+E+AVK + Q E ++ E L A L+H N++ L G Sbjct: 130 IGAGGFGQVYRATW-QGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRG 188 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ-----------------LDWGMRHRIIR 472 VCL+Q LV EF +L++ L ++W ++ Sbjct: 189 VCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQ----- 243 Query: 473 GIARGLQYLHEDS 511 IARG+ YLHE++ Sbjct: 244 -IARGMLYLHEEA 255
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 62.8 bits (151), Expect = 6e-10 Identities = 43/146 (29%), Positives = 79/146 (54%), Gaps = 11/146 (7%) Frame = +2 Query: 95 DTESVDSMLMDISTL----RAATGDFAESNKLGQGGFGAVYKGTLPDGEE----IAVKRL 250 D +++S L++ +TL D +LG+G FG VYKG L + +A+K L Sbjct: 385 DHVALNSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKAL 444 Query: 251 SKS-STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTE 427 ++ S + ++ K E+ L++ LKH+N+V ++GV L ++ +++E++ N L + L Sbjct: 445 KENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNS 504 Query: 428 --KGEQLDWGMRHRIIRGIARGLQYL 499 +G+ L +I I+ G+QYL Sbjct: 505 PTEGKSLSQLEFLQIALQISEGMQYL 530
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 62.4 bits (150), Expect = 7e-10 Identities = 42/118 (35%), Positives = 61/118 (51%), Gaps = 9/118 (7%) Frame = +2 Query: 176 LGQGGFGAVYKG-TLPDGEEIAVKRL-------SKSSTQG-VEELKNELALVAKLKHKNL 328 +G+G FG VY G L GE +AVK++ SK TQ ++EL+ E+ L+ L H N+ Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 134 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 VR +G E ++ EFVP S+ +L EK + R + GL+YLH Sbjct: 135 VRYLGTVREDDTLNILLEFVPGGSISSLL---EKFGPFPESVVRTYTRQLLLGLEYLH 189
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 62.0 bits (149), Expect = 9e-10 Identities = 37/116 (31%), Positives = 61/116 (52%), Gaps = 1/116 (0%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLV 331 D + LG+G FG VYKGTL D +AVK + Q ++ + E ++ + H N+V Sbjct: 63 DVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIV 122 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 +L+GVC ++Q ++ E VP D + F ++ ++L R +A G+ YL Sbjct: 123 KLIGVCTQRQPVYIIMELVPGG--DFLSFLRKRKDELKLKQLVRFSLDVAAGMLYL 176
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 61.6 bits (148), Expect = 1e-09 Identities = 36/120 (30%), Positives = 65/120 (54%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRL 337 F ++GQGGFG VY +GE++A+K++ +++Q +K E+ + L+H+N+V+ Sbjct: 13 FQNLQQIGQGGFGVVYSAQRENGEKVAIKKIGNAASQ--TRIKEEIKTMKLLRHRNIVQF 70 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 E E LV E SL + + +KG LD I+R + ++Y+H+++ L Sbjct: 71 YETFFENGETYLVMELCEGGSL--MDYVKQKG-PLDDSTAVHILRQLIAAVKYIHDENIL 127
>PIM1_BRARE (Q9YHZ5) Serine/threonine-protein kinase Pim-1 (EC 2.7.11.1)| Length = 310 Score = 61.2 bits (147), Expect = 2e-09 Identities = 47/159 (29%), Positives = 78/159 (49%), Gaps = 23/159 (14%) Frame = +2 Query: 95 DTESVDSMLMDISTLRAATG------DFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLS 253 D VD L + L+A G + N LG GGFG+VY G + DG+++A+K++S Sbjct: 3 DKRIVDVRLDQLEILKAKNGKEHFEKQYTMGNLLGSGGFGSVYSGHRISDGQKVAIKQIS 62 Query: 254 KSSTQ-------GVEELKNELALVAKL--------KHKNLVRLVG-VCLEQQERLLVYEF 385 + Q V + NE+AL+ L H+ ++R++ + QE L+V+E Sbjct: 63 RDRIQQWSKMPGEVNPVPNEIALLQSLGGGSGSVPGHRGIIRMLDWFEIPGQEYLIVFE- 121 Query: 386 VPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 P D F TE+G +LD + R ++ + +Q+ H Sbjct: 122 KPQHCQDLFDFITERG-RLDESLARRFLKQVIEAVQFCH 159
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 9/118 (7%) Frame = +2 Query: 176 LGQGGFGAVYKG-TLPDGEEIAVKRL-------SKSSTQG-VEELKNELALVAKLKHKNL 328 +G+G FG VY G L GE +AVK++ SK TQ ++EL+ E+ L+ L H N+ Sbjct: 74 IGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 133 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 VR +G E + ++ EFVP S+ +L EK + + GL+YLH Sbjct: 134 VRYLGTVREDETLNILLEFVPGGSISSLL---EKFGAFPESVVRTYTNQLLLGLEYLH 188
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/152 (27%), Positives = 74/152 (48%), Gaps = 4/152 (2%) Frame = +2 Query: 59 NQPYPSYSTE--GKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEE 232 +QP P+ + G D + +D D++ K+G G FG V++ G + Sbjct: 526 SQPVPNRANRELGLDGDDMDIPWCDLNI----------KEKIGAGSFGTVHRAEW-HGSD 574 Query: 233 IAVKRLSKSS--TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 406 +AVK L + + V E E+A++ +L+H N+V +G + +V E++ SL Sbjct: 575 VAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLY 634 Query: 407 QILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 ++L + EQLD R + +A+G+ YLH Sbjct: 635 RLLHKSGAREQLDERRRLSMAYDVAKGMNYLH 666
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 60.5 bits (145), Expect = 3e-09 Identities = 39/109 (35%), Positives = 63/109 (57%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 LG G FG+VY+ +GEE+AVK +K ++ + L+ EL ++ L H +L+ L+ + Sbjct: 1885 LGDGSFGSVYRAAY-EGEEVAVKIFNKHTS--LRLLRQELVVLCHLHHPSLISLLAAGI- 1940 Query: 356 QQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + R+LV E SLD++L + L ++HRI +A GL+YLH Sbjct: 1941 -RPRMLVMELASKGSLDRLL--QQDKASLTRTLQHRIALHVADGLRYLH 1986
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 60.5 bits (145), Expect = 3e-09 Identities = 39/109 (35%), Positives = 63/109 (57%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 LG G FG+VY+ +GEE+AVK +K ++ + L+ EL ++ L H +L+ L+ + Sbjct: 1885 LGDGSFGSVYRAAY-EGEEVAVKIFNKHTS--LRLLRQELVVLCHLHHPSLISLLAAGI- 1940 Query: 356 QQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + R+LV E SLD++L + L ++HRI +A GL+YLH Sbjct: 1941 -RPRMLVMELASKGSLDRLL--QQDKASLTRTLQHRIALHVADGLRYLH 1986
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 59.7 bits (143), Expect = 5e-09 Identities = 35/115 (30%), Positives = 64/115 (55%), Gaps = 2/115 (1%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVC 349 N++G+G FG+V++ E+A K L S + E+ E ++ KL+H+ +V L+GVC Sbjct: 224 NEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAER-EKFVLEAKIMHKLRHRKIVELLGVC 282 Query: 350 LEQQE--RLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 E Q+ L++ E++ N SL + L T G++ + ++ I+ G+ YL + Sbjct: 283 TEPQDMPMLIIVEYMKNGSLKEYL-KTPDGKKTNLNQMVHMMAEISEGMAYLESE 336
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 59.7 bits (143), Expect = 5e-09 Identities = 41/120 (34%), Positives = 61/120 (50%), Gaps = 9/120 (7%) Frame = +2 Query: 176 LGQGGFGAVYKG-TLPDGEEIAVKRL-------SKSSTQG-VEELKNELALVAKLKHKNL 328 +G G FG VY G L GE +A+K++ SK TQG + EL+ E+ L+ L H N+ Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNI 133 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 VR +G E ++ EFVP S+ +L EK + + + GL+YLH + Sbjct: 134 VRYLGTVRESDSLNILMEFVPGGSISSLL---EKFGSFPEPVIIMYTKQLLLGLEYLHNN 190
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 59.3 bits (142), Expect = 6e-09 Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 4/135 (2%) Frame = +2 Query: 110 DSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSK---SSTQGVEE 280 DS+ + + AT DF ++ K+ QG F VY+G G+ K+L + SS +E Sbjct: 194 DSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHR-HGKPFVFKKLRETACSSPGSIER 252 Query: 281 L-KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMR 457 + EL + + H N++ ++G C +Q +Y ++ N SL L + L W R Sbjct: 253 FFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQR 312 Query: 458 HRIIRGIARGLQYLH 502 I G+ ++YLH Sbjct: 313 VSICSGLLCAVEYLH 327
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 58.9 bits (141), Expect = 8e-09 Identities = 36/117 (30%), Positives = 63/117 (53%), Gaps = 6/117 (5%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGV------EELKNELALVAKLKHKNLVRL 337 LG+G +G VY G G+ IAVK+++ ++ + +L+ E+ L+ LKH N+V Sbjct: 1067 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAY 1126 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 +G CL++ + EFVP S+ I+ + L + + + I +G+ YLHE+ Sbjct: 1127 LGTCLQENTVSIFMEFVPGGSISSII---NRFGPLPEMVFCKYTKQILQGVAYLHEN 1180
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 58.9 bits (141), Expect = 8e-09 Identities = 43/143 (30%), Positives = 73/143 (51%), Gaps = 5/143 (3%) Frame = +2 Query: 104 SVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEEL 283 +V S + DI + +G GGF V++G DGEE+A+K ++ ++ + Sbjct: 124 NVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYY-DGEEVAIKIAHQTGEDDMQRM 182 Query: 284 KNELALVAKL----KHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQL-DW 448 ++ + AKL KH+N+ L GVCL + LV E+ SL++IL + L +W Sbjct: 183 RDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAGKIPPDVLVNW 241 Query: 449 GMRHRIIRGIARGLQYLHEDSQL 517 ++ IARG+ YLH ++ + Sbjct: 242 AIQ------IARGMNYLHNEAPM 258
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 58.5 bits (140), Expect = 1e-08 Identities = 35/119 (29%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +LKH N Sbjct: 3 DYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +VRL+ V +++ L++EF+ + L + L G+ +D + + I G+ + H Sbjct: 63 VVRLLDVLMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH 120
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 58.5 bits (140), Expect = 1e-08 Identities = 35/119 (29%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +LKH N Sbjct: 3 DYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +VRL+ V +++ L++EF+ + L + L G+ +D + + I G+ + H Sbjct: 63 VVRLLDVLMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH 120
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 58.5 bits (140), Expect = 1e-08 Identities = 35/119 (29%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +LKH N Sbjct: 3 DYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +VRL+ V +++ L++EF+ + L + L G+ +D + + I G+ + H Sbjct: 63 VVRLLDVLMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH 120
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 58.5 bits (140), Expect = 1e-08 Identities = 35/119 (29%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +LKH N Sbjct: 3 DYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +VRL+ V +++ L++EF+ + L + L G+ +D + + I G+ + H Sbjct: 63 VVRLLDVLMQESRLYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH 120
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/147 (29%), Positives = 73/147 (49%), Gaps = 9/147 (6%) Frame = +2 Query: 89 GKDTESVDSMLMDISTLRAATGDFAE--------SNKLGQGGFGAVYKGT-LPDGEEIAV 241 G D +V + S+ RA F+ K+G G F V+K G+ +A+ Sbjct: 27 GGDGNTVQVGRVSSSSYRAIISAFSRLTSLDDFTREKIGSGFFSEVFKVRHRASGQVMAL 86 Query: 242 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 421 K + SS + L E+ L+ +L H N++R +GVC+ Q + + E++ + +L+Q+L Sbjct: 87 KMNTLSSNRA--NLLKEMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLL-- 142 Query: 422 TEKGEQLDWGMRHRIIRGIARGLQYLH 502 + L W +R ++ IA GL YLH Sbjct: 143 -DSNLYLPWTVRVKLAYDIAVGLSYLH 168
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 58.2 bits (139), Expect = 1e-08 Identities = 36/113 (31%), Positives = 63/113 (55%), Gaps = 5/113 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL----PDGEEIAVKRLSKSSTQGV-EELKNELALVAKLKHKNLVRLV 340 +G+G FG VY+GTL D + +A+K L +S G E ++ + H +++ L Sbjct: 630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLE 689 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 GV +++ +++ EF+ N +LD L E+ +QL G +++GIA G+ YL Sbjct: 690 GVVTKRKPIMIITEFMENGALDAFL--REREDQLVPGQLVAMLQGIASGMNYL 740
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 58.2 bits (139), Expect = 1e-08 Identities = 35/145 (24%), Positives = 74/145 (51%), Gaps = 4/145 (2%) Frame = +2 Query: 95 DTESVDSMLMDISTLRAATG--DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQ 268 D + DS L + R + + ++G G +G V+ G G ++AVK+ K Sbjct: 1341 DIDKEDSFLTSANMCRWIINYDEISIGKQIGLGSYGIVFNGKWK-GVDVAVKKFVKQKLS 1399 Query: 269 GVE--ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQL 442 + E + E+A +++LKH N+V +G C+++ +V E++ +L +L + + ++ Sbjct: 1400 ETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPD--IKI 1457 Query: 443 DWGMRHRIIRGIARGLQYLHEDSQL 517 + + +++ G A G+ YLH + + Sbjct: 1458 TFANKLKLLYGAAMGIDYLHSSNPM 1482 Score = 46.6 bits (109), Expect = 4e-05 Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 5/121 (4%) Frame = +2 Query: 155 DFAE---SNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELK--NELALVAKLKH 319 DF+E LG GG+G VYK ++ G E+AVK +S E E+ ++ L+H Sbjct: 782 DFSELEIGETLGTGGYGEVYK-SIWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRH 840 Query: 320 KNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 N+V + + +V EF+ SL +L E ++ + ++ ++ ++G+ +L Sbjct: 841 PNVVLFMAASTKSPNMCIVMEFMSLGSLYDLL-GNELIPEIPYALKIKMAYQASKGMHFL 899 Query: 500 H 502 H Sbjct: 900 H 900
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 57.8 bits (138), Expect = 2e-08 Identities = 43/147 (29%), Positives = 73/147 (49%), Gaps = 9/147 (6%) Frame = +2 Query: 89 GKDTESVDSMLMDISTLRAATGDFAE--------SNKLGQGGFGAVYKGT-LPDGEEIAV 241 G D +V + S+ RA F+ K+G G F V+K G+ +A+ Sbjct: 27 GGDGNTVQVGRVSSSSYRAIISAFSRLTSLDDFTREKIGSGFFSEVFKVRHRASGQVMAL 86 Query: 242 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 421 K + SS + L E+ L+ +L H N++R +GVC+ Q + + E++ + +L+Q+L Sbjct: 87 KMNTLSSNRA--NLLKEMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLL-- 142 Query: 422 TEKGEQLDWGMRHRIIRGIARGLQYLH 502 + L W +R ++ IA GL YLH Sbjct: 143 -DSDLYLPWTVRVKLAYDIAVGLSYLH 168
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 57.4 bits (137), Expect = 2e-08 Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 6/118 (5%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVK--RLSKSSTQGV--EELKNELALVAKLKHKNLVRLVG 343 +G GGFG VY+ L GEE+AVK RL V E++ E L L+H N++ L G Sbjct: 104 IGVGGFGKVYRA-LWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRG 162 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ--LDWGMRHRIIRGIARGLQYLHEDS 511 CL LV E+ +L ++L ++W ++ +ARG+ YLH D+ Sbjct: 163 ACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQ------VARGMNYLHNDA 214
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 1/109 (0%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCL 352 LG+G FG VYKGTL D +AVK + Q ++ + E ++ + H N+V+L+GVC Sbjct: 569 LGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 628 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 ++Q ++ E V D + F K ++L + A G+ YL Sbjct: 629 QRQPVYIIMELVSGG--DFLTFLRRKKDELKLKQLVKFSLDAAAGMLYL 675
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 57.0 bits (136), Expect = 3e-08 Identities = 47/180 (26%), Positives = 83/180 (46%), Gaps = 18/180 (10%) Frame = +2 Query: 14 GLFIWRRRRR------------SPAQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGD 157 GLFI RRRR S ++ +P +Y + ++L + + + Sbjct: 556 GLFIHRRRRNLRARQSSEDVRFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSC-- 613 Query: 158 FAESNKLGQGGFGAVYKGTLPDGE-----EIAVKRLSKSSTQGVE-ELKNELALVAKLKH 319 A +G G FG VYKGTL +A+K L T+ + +E +++ + H Sbjct: 614 VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSH 673 Query: 320 KNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 N++ L GV + + +++ E++ N +LD+ L EK + ++RGIA G++YL Sbjct: 674 HNIIPLEGVVSKYKPMMIITEYMENGALDKFL--REKDGEFSVLQLVGMLRGIASGMKYL 731
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 57.0 bits (136), Expect = 3e-08 Identities = 33/110 (30%), Positives = 60/110 (54%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 K+G G F V+K ++ +++ S+ LK E+ L+ +L H N++R +GVC+ Sbjct: 63 KIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLK-EVQLMNRLSHPNILRFMGVCV 121 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 Q + + E++ + +L+Q+L + L W +R ++ IA GL YLH Sbjct: 122 HQGQLHALTEYINSGNLEQLL---DSNLHLPWTVRVKLAYDIAVGLSYLH 168
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 57.0 bits (136), Expect = 3e-08 Identities = 35/119 (29%), Positives = 68/119 (57%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +L+H N Sbjct: 3 DYLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLKELQHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +VRL+ V +++ + LV+EF+ + L + L G+ +D + + I G+ + H Sbjct: 63 VVRLLDVLMQESKLYLVFEFL-SMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCH 120
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/115 (33%), Positives = 57/115 (49%), Gaps = 6/115 (5%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGV----EELKNELALVAKLKHKNLVRLVG 343 +G GGFG VY+G+ GE +AVK + + + E ++ E L A L H N++ L Sbjct: 123 IGIGGFGKVYRGSWR-GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKA 181 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ--LDWGMRHRIIRGIARGLQYLH 502 VCLE+ LV E+ L + L ++W ++ IARG+ YLH Sbjct: 182 VCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQ------IARGMHYLH 230
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 56.6 bits (135), Expect = 4e-08 Identities = 41/119 (34%), Positives = 63/119 (52%), Gaps = 9/119 (7%) Frame = +2 Query: 176 LGQGGFGAVYKGT-LPDGEEI----AVKRLSKSS-TQGVEELKNELALVAKLKHKNLVRL 337 LG G FG VYKG +P+GE + A+K L KS+ + EE E ++A +H NL++L Sbjct: 944 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKL 1003 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARGLQYLHE 505 + VC+ Q L+ LD + + +K G + L+W + IA+G+ YL E Sbjct: 1004 LAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQ------IAKGMSYLEE 1056
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 56.6 bits (135), Expect = 4e-08 Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 1/116 (0%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D +KLG G +G VY+ G +AVK L K T +++ E A++ ++KH NLV Sbjct: 370 DIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTL-KEDTMALKDFLEEAAIMKEMKHPNLV 428 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 +L+GVC + ++ EF+ + +L L + E LD + IA G+ YL Sbjct: 429 QLIGVCTREPPFYIITEFMSHGNLLDFLRSAGR-ETLDAVALLYMATQIASGMSYL 483
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 11/122 (9%) Frame = +2 Query: 176 LGQGGFGAVYKGTL----PDGEEIAVKRLSKSSTQGV-EELKNELALVAKLKHKNLVRLV 340 +G+G FG VY+G L D + +A+K L +S G E ++ + H +++RL Sbjct: 631 IGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLE 690 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGL------QYLH 502 GV +++ +++ EF+ N +LD L E+ +QL G ++ GIA G+ Y+H Sbjct: 691 GVITKRKPIMIITEFMENGALDAFL--KEREDQLAPGQLVAMLLGIASGMNCLSGHNYVH 748 Query: 503 ED 508 D Sbjct: 749 RD 750
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 56.2 bits (134), Expect = 5e-08 Identities = 42/111 (37%), Positives = 60/111 (54%), Gaps = 1/111 (0%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGV 346 NKLG G +G VY+G + IAVK L K + E E A++ L HKNLVRL+GV Sbjct: 315 NKLGGGQYGDVYEGYWKRHDCTIAVKAL-KEDAMPLHEFLAEAAIMKDLHHKNLVRLLGV 373 Query: 347 CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 C + ++ EF+ N +L + L T+K L + ++ IA G+ YL Sbjct: 374 CTHEAPFYIITEFMCNGNLLEYLRRTDK-SLLPPIILVQMASQIASGMSYL 423
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 55.8 bits (133), Expect = 7e-08 Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 17/143 (11%) Frame = +2 Query: 128 ISTLRAATGDFAESNKLGQGGFGAVYK----GTLPDGEE--IAVKRLSKSSTQGVE-ELK 286 + L GD LGQG FG V++ G +PD E+ +AVK L ++ ++ + + Sbjct: 431 LEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFE 490 Query: 287 NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQIL----------FDTEKGE 436 E L+A+ H N+VRL+GVC + L++E++ L + L T+ Sbjct: 491 REACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRL 550 Query: 437 QLDWGMRHRIIRGIARGLQYLHE 505 QL+ ++ IA G+ YL E Sbjct: 551 QLNELHLLQMAANIAAGMLYLSE 573
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/115 (33%), Positives = 61/115 (53%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLV 340 +G G FG VYKG L P EI A+K L S + + +E +++ + H N++RL Sbjct: 543 IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 602 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + +++ EF+ N +LD L + Q ++RGIA G++YL E Sbjct: 603 GVVTKSRPVMIITEFMENGALDSFL--RQNDGQFTVIQLVGMLRGIAAGMKYLSE 655
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/119 (27%), Positives = 65/119 (54%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +L+H N Sbjct: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L V ++ L++EF+ + L + L G+ +D + + I +G+ + H Sbjct: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 55.1 bits (131), Expect = 1e-07 Identities = 38/115 (33%), Positives = 61/115 (53%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLV 340 +G G FG VYKG L P EI A+K L S + + +E +++ + H N++RL Sbjct: 626 IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 685 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + +++ EF+ N +LD L + Q ++RGIA G++YL E Sbjct: 686 GVVTKSRPVMIITEFMENGALDSFL--RQNDGQFTVIQLVGMLRGIAAGMKYLSE 738
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D +KLG G +G VY+G +AVK L K T VEE E A++ ++KH NLV Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLV 299 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGE 436 +L+GVC + ++ EF+ +L L + + E Sbjct: 300 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 334
>ATG1_KLULA (Q6CSX2) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 831 Score = 54.7 bits (130), Expect = 2e-07 Identities = 37/131 (28%), Positives = 73/131 (55%), Gaps = 4/131 (3%) Frame = +2 Query: 98 TESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQG- 271 +ES D ++ +R T +++ ++G+G F VYKG +L DG IA+K +S+S + Sbjct: 3 SESHDKVVA--KAIRLPTENYSVEKEIGKGSFAVVYKGLSLRDGRNIAIKAVSRSKLKNK 60 Query: 272 --VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLD 445 +E L+ E+A++ K+KH ++V L+ + L+ E+ +L + F +K + L Sbjct: 61 KLLENLEVEIAILKKIKHPHIVGLIDCERTSSDFYLIMEYC---ALGDLTFFIKKRKNL- 116 Query: 446 WGMRHRIIRGI 478 ++H +I+ + Sbjct: 117 -VLKHPLIKTV 126
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D +KLG G +G VY+G +AVK L K T VEE E A++ ++KH NLV Sbjct: 127 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLV 185 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGE 436 +L+GVC + ++ EF+ +L L + + E Sbjct: 186 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 220
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D +KLG G +G VY+G +AVK L K T VEE E A++ ++KH NLV Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLV 299 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGE 436 +L+GVC + ++ EF+ +L L + + E Sbjct: 300 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 334
>WRK19_ARATH (Q9SZ67) Probable WRKY transcription factor 19 (WRKY DNA-binding| protein 19) Length = 1895 Score = 54.7 bits (130), Expect = 2e-07 Identities = 37/138 (26%), Positives = 70/138 (50%), Gaps = 9/138 (6%) Frame = +2 Query: 119 LMDISTLRAATGDFA----ESNKLGQGGFGAVYKGTLPDGEEIAVKRLS-----KSSTQG 271 + + S + A+ G F + LG+G G+VY+G DG+ A K +S + + Sbjct: 1609 ISNTSPIYASEGSFITCWQKGQLLGRGSLGSVYEGISADGDFFAFKEVSLLDQGSQAHEW 1668 Query: 272 VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWG 451 +++++ +AL+++L+H+N+VR G ++ + E V SL ++ + QL Sbjct: 1669 IQQVEGGIALLSQLQHQNIVRYRGTTKDESNLYIFLELVTQGSLRKLY----QRNQLGDS 1724 Query: 452 MRHRIIRGIARGLQYLHE 505 + R I GL+YLH+ Sbjct: 1725 VVSLYTRQILDGLKYLHD 1742
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 54.7 bits (130), Expect = 2e-07 Identities = 35/95 (36%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D +KLG G +G VY G +AVK L K T VEE E A++ ++KH NLV Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLV 345 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGE 436 +L+GVC + +V E++P +L L + + E Sbjct: 346 QLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 54.7 bits (130), Expect = 2e-07 Identities = 38/115 (33%), Positives = 61/115 (53%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLV 340 +G G FG VYKG L P EI A+K L S + + +E +++ + H N++RL Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 684 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + +++ EF+ N +LD L + Q ++RGIA G++YL E Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFL--RQNDGQFTVIQLVGMLRGIAAGMKYLSE 737
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 1/95 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKNLV 331 D +KLG G +G VY+G +AVK L K T VEE E A++ ++KH NLV Sbjct: 190 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLV 248 Query: 332 RLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGE 436 +L+GVC + ++ EF+ +L L + + E Sbjct: 249 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 283
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 54.7 bits (130), Expect = 2e-07 Identities = 34/118 (28%), Positives = 65/118 (55%), Gaps = 3/118 (2%) Frame = +2 Query: 173 KLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVE-ELKNELALVAKLKHKNLVRLVG 343 K+G+G +G V++ + G +AVKR+ + +GV E++++ +L+H+N+VRL+ Sbjct: 10 KIGEGSYGVVFRARDVTTGTIVAVKRIRLEKEEEGVPCTAIREISILKELRHENIVRLLD 69 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 VC ++ LV+E + +D + G LD G +R + G+++ HE + L Sbjct: 70 VCHSEKRLTLVFECM---EMDLKKYMDHVGGDLDAGTIQEFMRSLLSGVRFCHERNVL 124
>BMPR2_MOUSE (O35607) Bone morphogenetic protein receptor type-2 precursor (EC| 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3) Length = 1038 Score = 54.3 bits (129), Expect = 2e-07 Identities = 42/116 (36%), Positives = 60/116 (51%), Gaps = 5/116 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR-LVG--- 343 +G+G +GAVYKG+L D +AVK S ++ Q KN + V ++H N+ R +VG Sbjct: 209 IGRGRYGAVYKGSL-DERPVAVKVFSFANRQNFINEKN-IYRVPLMEHDNIARFIVGDER 266 Query: 344 -VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 + E LLV E+ PN SL + L DW R+ + RGL YLH + Sbjct: 267 LTADGRMEYLLVMEYYPNGSLCKYL----SLHTSDWVSSCRLAHSVTRGLAYLHTE 318
>BMPR2_HUMAN (Q13873) Bone morphogenetic protein receptor type-2 precursor (EC| 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) Length = 1038 Score = 54.3 bits (129), Expect = 2e-07 Identities = 42/116 (36%), Positives = 60/116 (51%), Gaps = 5/116 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR-LVG--- 343 +G+G +GAVYKG+L D +AVK S ++ Q KN + V ++H N+ R +VG Sbjct: 209 IGRGRYGAVYKGSL-DERPVAVKVFSFANRQNFINEKN-IYRVPLMEHDNIARFIVGDER 266 Query: 344 -VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 + E LLV E+ PN SL + L DW R+ + RGL YLH + Sbjct: 267 VTADGRMEYLLVMEYYPNGSLCKYL----SLHTSDWVSSCRLAHSVTRGLAYLHTE 318
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 54.3 bits (129), Expect = 2e-07 Identities = 38/115 (33%), Positives = 61/115 (53%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLV 340 +G G FG VYKG L P EI A+K L S + + +E +++ + H N++RL Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 684 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + +++ EF+ N +LD L + Q ++RGIA G++YL E Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFL--RQNDGQFTVIQLVGMLRGIAAGMKYLAE 737
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 54.3 bits (129), Expect = 2e-07 Identities = 38/115 (33%), Positives = 61/115 (53%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLV 340 +G G FG VYKG L P EI A+K L S + + +E +++ + H N++RL Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 684 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + +++ EF+ N +LD L + Q ++RGIA G++YL E Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFL--RQNDGQFTVIQLVGMLRGIAAGMKYLAE 737
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/119 (27%), Positives = 65/119 (54%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +L+H N Sbjct: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L V ++ L++EF+ + L + L G+ +D + + I +G+ + H Sbjct: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCH 120
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 54.3 bits (129), Expect = 2e-07 Identities = 35/126 (27%), Positives = 64/126 (50%), Gaps = 3/126 (2%) Frame = +2 Query: 149 TGDFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVE-ELKNELALVAKLKH 319 T + K+G+G +G VYK +A+KR+ S +GV E++L+ +L+H Sbjct: 2 TSRYERQEKIGEGTYGVVYKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLKELRH 61 Query: 320 KNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 +N+V+L+ VC + +V+E++ LD + + LD +R + RG+ + Sbjct: 62 ENIVKLLDVCHSEHRLTIVFEYL---DLDLKKYLDRENGNLDAATIQHFMRDLLRGVAFC 118 Query: 500 HEDSQL 517 H+ S L Sbjct: 119 HQRSVL 124
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 53.9 bits (128), Expect = 3e-07 Identities = 34/114 (29%), Positives = 58/114 (50%), Gaps = 6/114 (5%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGE-----EIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRL 337 +G G FG VYKG L +A+K L T+ + E ++ + H N++RL Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 678 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 GV + + +++ E++ N +LD+ L EK + ++RGIA G++YL Sbjct: 679 EGVISKYKPMMIITEYMENGALDKFL--REKDGEFSVLQLVGMLRGIAAGMKYL 730
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 53.9 bits (128), Expect = 3e-07 Identities = 33/119 (27%), Positives = 65/119 (54%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +L+H N Sbjct: 3 DYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L V ++ L++EF+ + L + L G+ +D + + I +G+ + H Sbjct: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCH 120
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 53.9 bits (128), Expect = 3e-07 Identities = 37/115 (32%), Positives = 58/115 (50%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 KLG+G FG V+ G + ++AVK L + T E A++ K +H LV L VC Sbjct: 289 KLGRGNFGEVFYGKWRNSIDVAVKTL-REGTMSTAAFLQEAAIMKKFRHNRLVALYAVCS 347 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 +++ +V E++ SL L + + G L + I +A G++YL E QL Sbjct: 348 QEEPIYIVQEYMSKGSLLDFLREGD-GRYLHFEDLIYIATQVASGMEYL-ESKQL 400
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 53.9 bits (128), Expect = 3e-07 Identities = 34/121 (28%), Positives = 61/121 (50%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 + A ++G G FG V+ G ++A+K +++ S E+ E ++ KL H LV+ Sbjct: 270 ELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGS-MSEEDFIEEAKVMMKLSHSKLVQ 328 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQ 514 L GVC++++ +V EF+ N L L E +L M + + I G++YL + Sbjct: 329 LYGVCIQRKPLYIVTEFMENGCLLNYL--RENKGKLRKEMLLSVCQDICEGMEYLERNGY 386 Query: 515 L 517 + Sbjct: 387 I 387
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 53.5 bits (127), Expect = 3e-07 Identities = 41/126 (32%), Positives = 68/126 (53%), Gaps = 9/126 (7%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEI----AVKRLSKSSTQGV-EELKNELALVAKLK 316 +F + LG G FG VYKG PDGE I A+K L ++++ V +E+ +E ++A + Sbjct: 709 EFKKDRVLGSGAFGTVYKGLWNPDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVD 768 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK--GE-QLDWGMRHRIIRGIARG 487 H ++ RL+G+CL +L+ LD + E+ G+ L+W ++ IA+G Sbjct: 769 HPHVCRLLGICLTSAVQLVTQLMPYGCLLDYVRQHQERICGQWLLNWCVQ------IAKG 822 Query: 488 LQYLHE 505 + YL E Sbjct: 823 MNYLEE 828
>KIN31_CAEEL (P34265) Probable tyrosine-protein kinase kin-31 (EC 2.7.10.2)| Length = 437 Score = 53.5 bits (127), Expect = 3e-07 Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 8/125 (6%) Frame = +2 Query: 152 GDFAESNKLGQGGFGAVYKGTLPDGE-----EIAVKRLSKSSTQGVEELKN---ELALVA 307 G+ KLG+G FG V G + ++AVK++ K+ G +++K+ E + Sbjct: 128 GNIVIEKKLGEGAFGEVSSGVMKFKRGGRLVKVAVKQV-KTDGIGKDQIKDFLMEARTMR 186 Query: 308 KLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARG 487 L H N+VR +G+ + Q+ LV E +LD L + E L RH ++ A G Sbjct: 187 NLGHPNIVRFLGIAVLQEPLFLVMELATGGALDSYL---KHNELLPIDKRHEMLLQAAWG 243 Query: 488 LQYLH 502 L+Y+H Sbjct: 244 LEYIH 248
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 53.5 bits (127), Expect = 3e-07 Identities = 28/87 (32%), Positives = 53/87 (60%), Gaps = 6/87 (6%) Frame = +2 Query: 173 KLGQGGFGAVY----KGTLPDGEE--IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ LP+ ++ +AVK L ++S ++ + E L+ L+H+++VR Sbjct: 515 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVR 574 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL 415 GVC E + L+V+E++ + L++ L Sbjct: 575 FFGVCTEGRPLLMVFEYMRHGDLNRFL 601
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 53.5 bits (127), Expect = 3e-07 Identities = 33/119 (27%), Positives = 65/119 (54%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +L+H N Sbjct: 3 DYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L V ++ L++EF+ + L + L G+ +D + + I +G+ + H Sbjct: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCH 120
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 53.5 bits (127), Expect = 3e-07 Identities = 32/119 (26%), Positives = 64/119 (53%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ + +K++ +S +GV E++L+ +L+H N Sbjct: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVTMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L V ++ L++EF+ + L + L G+ +D + + I +G+ + H Sbjct: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 53.5 bits (127), Expect = 3e-07 Identities = 42/126 (33%), Positives = 66/126 (52%), Gaps = 6/126 (4%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGTLPDGEEI-AVKRLS-KSSTQGV-EELKNELALVAKLKHKNL 328 + + K+G+G +G V+KG D EI A+KR+ +GV E+ L+ +LKHKN+ Sbjct: 4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNI 63 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQIL---FDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+ V ++ LV+E DQ L FD+ GE +D + + + RGL + Sbjct: 64 VRLIDVLHSDKKLTLVFE-----HCDQDLKKYFDSLNGE-IDMAVCRSFMLQLLRGLAFC 117 Query: 500 HEDSQL 517 H + L Sbjct: 118 HSHNVL 123
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 53.5 bits (127), Expect = 3e-07 Identities = 35/115 (30%), Positives = 58/115 (50%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 + A ++G G FG V+ G +A+K +++ S E+ E ++ KL H LV+ Sbjct: 270 ELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGS-MSEEDFIEEAKVMMKLSHSRLVQ 328 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 L GVC++Q+ +V EF+ N L L E+ QL + + + I G+ YL Sbjct: 329 LYGVCIQQKPLYIVTEFMENGCLLDYL--RERKGQLQKALLLSMCQDICEGMAYL 381
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 53.1 bits (126), Expect = 4e-07 Identities = 43/157 (27%), Positives = 67/157 (42%), Gaps = 11/157 (7%) Frame = +2 Query: 71 PSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTL------PDGEE 232 P+Y GK + D + + G LG G FG VY+G + P + Sbjct: 1098 PNYCFAGKTSSISDLKEVPRKNITLIRG-------LGHGAFGEVYEGQVSGMPNDPSPLQ 1150 Query: 233 IAVKRLSK-SSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 409 +AVK L + S Q + E +++K H+N+VR +GV L+ R ++ E + L Sbjct: 1151 VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKS 1210 Query: 410 ILFDTEKGEQLDWGMRH----RIIRGIARGLQYLHED 508 L +T + + R IA G QYL E+ Sbjct: 1211 FLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEEN 1247
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 53.1 bits (126), Expect = 4e-07 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 4/121 (3%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEI-AVKRLSKS--STQGVE-ELKNELALVAKLKHK 322 DF LG+G FG VY L + I A+K L KS +G+E +L+ E+ + A L+H+ Sbjct: 15 DFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHR 74 Query: 323 NLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 N++RL + L+ E+ P L + + ++ ++LD II+ ++ L Y H Sbjct: 75 NILRLYNYFYDDTRIYLILEYAPGGELYK---ELQRHQKLDQQRTATIIQELSDALTYCH 131 Query: 503 E 505 E Sbjct: 132 E 132
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 53.1 bits (126), Expect = 4e-07 Identities = 43/157 (27%), Positives = 67/157 (42%), Gaps = 11/157 (7%) Frame = +2 Query: 71 PSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTL------PDGEE 232 P+Y GK + D + + G LG G FG VY+G + P + Sbjct: 1094 PNYCFAGKTSSISDLKEVPRKNITLIRG-------LGHGAFGEVYEGQVSGMPNDPSPLQ 1146 Query: 233 IAVKRLSK-SSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 409 +AVK L + S Q + E +++K H+N+VR +GV L+ R ++ E + L Sbjct: 1147 VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKS 1206 Query: 410 ILFDTEKGEQLDWGMRH----RIIRGIARGLQYLHED 508 L +T + + R IA G QYL E+ Sbjct: 1207 FLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEEN 1243
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 53.1 bits (126), Expect = 4e-07 Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 10/120 (8%) Frame = +2 Query: 176 LGQGGFGAVYKGT-LPDGEEI----AVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRL 337 LG G FG VYKG +P+GE + A+K L++++ E +E ++A + H +LVRL Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTEK--GEQ--LDWGMRHRIIRGIARGLQYLHE 505 +GVCL + LV + +P+ L + + + + G Q L+W ++ IA+G+ YL E Sbjct: 784 LGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQ------IAKGMMYLEE 836
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase| 2) (JAK-2) Length = 1132 Score = 52.8 bits (125), Expect = 6e-07 Identities = 38/118 (32%), Positives = 54/118 (45%), Gaps = 18/118 (15%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD--------GEEIAVKRLSKSSTQGVEELKNELALVAK 310 D + LGQG F ++KG + E+ +K L K+ E ++++K Sbjct: 544 DLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSK 603 Query: 311 LKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD----------QILFDTEKGEQLDWGM 454 L HK+LV GVC+ E +LV EFV SLD IL+ E +QL W M Sbjct: 604 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAM 661 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/116 (31%), Positives = 62/116 (53%), Gaps = 7/116 (6%) Frame = +2 Query: 173 KLGQGGFGAVYK---GTLPD--GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRL 337 +LG+G FG+V L D GE +AVK+L S+ + + + + E+ ++ L+H N+V+ Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 338 VGVCLEQQER--LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 GVC R L+ E++P SL L + E++D + I +G++YL Sbjct: 914 KGVCYSAGRRNLKLIMEYLPYGSLRDYL--QKHKERIDHIKLLQYTSQICKGMEYL 967
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 52.8 bits (125), Expect = 6e-07 Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 11/179 (6%) Frame = +2 Query: 14 GLFIWRRRRRSPAQANQPYPSYSTEGKDTESVDSMLMDISTLRAA--TGDFAESNKLGQG 187 G F++ R RR Q + Y G+ E +D L + + LG G Sbjct: 659 GSFLYWRGRR--IQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSG 716 Query: 188 GFGAVYKGT-LPDGEEIAVKRL-----SKSSTQGVEELKNELALVAKLKHKNLVRLVGVC 349 FG V+KG +P+GE I + KS Q + + + + V L H ++VRL+G+C Sbjct: 717 VFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLC 776 Query: 350 LEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARGLQYLHEDSQL 517 +L+ LD + E G Q L+WG++ IA+G+ YL E S + Sbjct: 777 PGSSLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQ------IAKGMYYLEEHSMV 829
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 52.8 bits (125), Expect = 6e-07 Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 11/179 (6%) Frame = +2 Query: 14 GLFIWRRRRRSPAQANQPYPSYSTEGKDTESVDSMLMDISTLRAA--TGDFAESNKLGQG 187 G F++ R RR Q + Y G+ E +D L + + LG G Sbjct: 659 GSFLYWRGRR--IQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSG 716 Query: 188 GFGAVYKGT-LPDGEEIAVKRL-----SKSSTQGVEELKNELALVAKLKHKNLVRLVGVC 349 FG V+KG +P+GE I + KS Q + + + + V L H ++VRL+G+C Sbjct: 717 VFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLC 776 Query: 350 LEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARGLQYLHEDSQL 517 +L+ LD + E G Q L+WG++ IA+G+ YL E S + Sbjct: 777 PGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQ------IAKGMYYLEEHSMV 829
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 52.8 bits (125), Expect = 6e-07 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 611 DVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNI 670 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F KG +L +++ A G++YL Sbjct: 671 VRLIGVCTQKQPIYIVMELV--QGGDFLSFLRSKGPRLKMKKLIKMMENAAAGMEYL 725
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 52.8 bits (125), Expect = 6e-07 Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 10/120 (8%) Frame = +2 Query: 176 LGQGGFGAVYKGT-LPDGEEI----AVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRL 337 LG G FG VYKG +P+GE + A+K L++++ E +E ++A + H +LVRL Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRL 783 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTEK--GEQ--LDWGMRHRIIRGIARGLQYLHE 505 +GVCL + LV + +P+ L + + + + G Q L+W ++ IA+G+ YL E Sbjct: 784 LGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQ------IAKGMMYLEE 836
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 52.8 bits (125), Expect = 6e-07 Identities = 37/148 (25%), Positives = 71/148 (47%), Gaps = 5/148 (3%) Frame = +2 Query: 74 SYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT-LPDGEEIA 238 S + K T+ D +M+ + GD + K+GQG G V+ T + G+E+A Sbjct: 217 SSDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVA 276 Query: 239 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 418 +K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL ++ Sbjct: 277 IKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVT 336 Query: 419 DTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +T +D + R + L++LH Sbjct: 337 ET----CMDEAQIAAVCRECLQALEFLH 360
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 52.4 bits (124), Expect = 7e-07 Identities = 34/119 (28%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 D+ + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +L H N Sbjct: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L V ++ L++EF+ + L + L G+ LD + I +G+ + H Sbjct: 63 IVCLQDVLMQDARLYLIFEFL-SMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCH 120
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 52.4 bits (124), Expect = 7e-07 Identities = 36/116 (31%), Positives = 62/116 (53%), Gaps = 7/116 (6%) Frame = +2 Query: 173 KLGQGGFGAVYK---GTLPD--GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRL 337 +LG+G FG+V L D GE +AVK+L S+ + + + + E+ ++ L+H N+V+ Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 338 VGVCLEQQER--LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 GVC R L+ E++P SL L + E++D + I +G++YL Sbjct: 914 KGVCYSAGRRNLRLIMEYLPYGSLRDYL--QKHKERIDHKKLLQYTSQICKGMEYL 967 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD--------GEEIAVKRLSKSSTQGVEELKNELALVAK 310 D + LGQG F ++KG + E+ +K L K+ E +++++ Sbjct: 544 DLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQ 603 Query: 311 LKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGL 490 L HK+LV GVC+ +E +LV EFV SLD L + + W + + + +A + Sbjct: 604 LSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKL--GVAKQLAWAM 661 Query: 491 QYLHEDS 511 +L E S Sbjct: 662 HFLEEKS 668
>ANPRB_ANGJA (P55202) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1050 Score = 52.4 bits (124), Expect = 7e-07 Identities = 26/93 (27%), Positives = 48/93 (51%) Frame = +2 Query: 224 GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 G +A+K ++K + ++ EL + ++ +L R +G C++ +V E+ P SL Sbjct: 549 GNLVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 608 Query: 404 DQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 IL + LDW R+ +I I +G+ +LH Sbjct: 609 QDIL--ENESINLDWMFRYSLINDIVKGMNFLH 639
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 52.4 bits (124), Expect = 7e-07 Identities = 41/147 (27%), Positives = 66/147 (44%), Gaps = 3/147 (2%) Frame = +2 Query: 71 PSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRL 250 P ++ GK S D L T + +E LG G GAV+ G EE+A+K++ Sbjct: 140 PVWNIIGK-AYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFR-AEEVAIKKV 197 Query: 251 SKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK 430 + + ++ L+ KLKH N++ GVC + ++ E+ + L ++L K Sbjct: 198 REQNETDIKHLR-------KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK 250 Query: 431 GEQ---LDWGMRHRIIRGIARGLQYLH 502 +DW GIA G+ YLH Sbjct: 251 ITPRLLVDWS------TGIASGMNYLH 271
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 52.4 bits (124), Expect = 7e-07 Identities = 33/124 (26%), Positives = 62/124 (50%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 FA+ ++G G FGAVY + + E +A+K++S K S + +++ E+ + KL+H N Sbjct: 28 FADLREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 + G L + LV E+ + D + + ++++ I G +GL YLH Sbjct: 88 TIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEMEIA---AITHGALQGLAYLHN 144 Query: 506 DSQL 517 + + Sbjct: 145 HNMI 148
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 52.4 bits (124), Expect = 7e-07 Identities = 35/119 (29%), Positives = 63/119 (52%), Gaps = 5/119 (4%) Frame = +2 Query: 161 AESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKNELALVAKLKHKN---- 325 A+ + L +G G V D +AVK L T ++ +N++ A++ HK Sbjct: 19 ADLHYLSRGASGTVSSARHADWRVRVAVKHLH-IHTPLLDSERNDILREAEILHKARFSY 77 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 ++ ++G+C E + +V E++PN SL+++L + + W +R RI+ IA G+ YLH Sbjct: 78 ILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLH 136
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 52.4 bits (124), Expect = 7e-07 Identities = 30/87 (34%), Positives = 49/87 (56%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 ++G G FG V+ G + +++A+K + + E+ E ++ KL H LV+L GVCL Sbjct: 368 EIGSGQFGLVHLGYWLNKDKVAIKTI-REGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCL 426 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKG 433 EQ LV+EF+ + L L T++G Sbjct: 427 EQAPICLVFEFMEHGCLSDYL-RTQRG 452
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 52.4 bits (124), Expect = 7e-07 Identities = 34/115 (29%), Positives = 59/115 (51%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 +LG G FG V +G + AVK + K T ++ E ++ KL+H NLV+L GVC Sbjct: 531 ELGSGQFGVVRRGKWRGSIDTAVKMM-KEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCS 589 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 + + +V E++ + SL L EK + G+ + +++G+ YL + + Sbjct: 590 KHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYI 644
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 52.4 bits (124), Expect = 7e-07 Identities = 36/116 (31%), Positives = 62/116 (53%), Gaps = 7/116 (6%) Frame = +2 Query: 173 KLGQGGFGAVYK---GTLPD--GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRL 337 +LG+G FG+V L D GE +AVK+L S+ + + + + E+ ++ L+H N+V+ Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 338 VGVCLEQQER--LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 GVC R L+ E++P SL L + E++D + I +G++YL Sbjct: 914 KGVCYSAGRRNLRLIMEYLPYGSLRDYL--QKHKERIDHKKLLQYTSQICKGMEYL 967 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPD--------GEEIAVKRLSKSSTQGVEELKNELALVAK 310 D + LGQG F ++KG + E+ +K L K+ E +++++ Sbjct: 544 DLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQ 603 Query: 311 LKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGL 490 L HK+LV GVC+ +E +LV EFV SLD L + + W + + + +A + Sbjct: 604 LSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKL--GVAKQLAWAM 661 Query: 491 QYLHEDS 511 +L E S Sbjct: 662 HFLEEKS 668
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 52.0 bits (123), Expect = 1e-06 Identities = 29/86 (33%), Positives = 48/86 (55%), Gaps = 2/86 (2%) Frame = +2 Query: 143 AATGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAKLK 316 +++ F + KLG G + VYKG G +A+K + S +G E++L+ +LK Sbjct: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPN 394 H+N+VRL V + + LV+EF+ N Sbjct: 62 HENIVRLYDVIHTENKLTLVFEFMDN 87
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 52.0 bits (123), Expect = 1e-06 Identities = 39/130 (30%), Positives = 63/130 (48%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + +N A +A+L H N++R+V Sbjct: 65 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTRTLRASQRNFWAELNIARLHHDNIIRVVA 123 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++ + EQL G + I G Sbjct: 124 ASTRTPEGSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDIVNG 183 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 184 LLFLHSQSIL 193
>M3K4_HUMAN (Q9Y6R4) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 52.0 bits (123), Expect = 1e-06 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPD-GEEIAVK--RLSKSSTQGVEELKNELALVA 307 LR T + NK+G+G +G VY D GE +A+K R + + ++E +EL + Sbjct: 1335 LRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFE 1394 Query: 308 KLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 412 +KH NLVR GV L ++E + E+ +L+++ Sbjct: 1395 GIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV 1429
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 52.0 bits (123), Expect = 1e-06 Identities = 36/115 (31%), Positives = 60/115 (52%), Gaps = 7/115 (6%) Frame = +2 Query: 176 LGQGGFGAV----YKGTLPDGEEIAVKRLS-KSSTQGVEELKNELALVAKLKHKNLVRLV 340 LG+G FG V Y GE++AVK L +S + +LK E+ ++ L H+N+V+ Sbjct: 870 LGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYK 929 Query: 341 GVCLEQQER--LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 G+C E L+ EF+P+ SL + L + L +++ + I +G+ YL Sbjct: 930 GICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV--QICKGMDYL 982 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 11/144 (7%) Frame = +2 Query: 119 LMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPD-------GEEIAVKRLSKSSTQGVE 277 + +S R D + LG+G +Y GTL D EE +K + K Sbjct: 558 MSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHR 617 Query: 278 ELK----NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLD 445 ++ +++ ++ HK++V L GVC+ E ++V EFV LD LF K + L Sbjct: 618 DISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLD--LFMHRKSDVLT 675 Query: 446 WGMRHRIIRGIARGLQYLHEDSQL 517 + ++ + +A L YL ED L Sbjct: 676 TPWKFKVAKQLASALSYL-EDKDL 698
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 52.0 bits (123), Expect = 1e-06 Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 7/173 (4%) Frame = +2 Query: 5 HEAGLFIWRRRRRSPAQANQPYPSYSTE----GKDTESVDSMLMDISTLRAATG--DFAE 166 ++ G R RRS + + P PS E +D +S+ S + D Sbjct: 274 NQEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIH 333 Query: 167 SNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVG 343 LG+G FG K T G+ + +K L + + + E+ ++ L H N+++ +G Sbjct: 334 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 V + ++ L+ E++ +L L + + W + R +GIA G+ YLH Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFLRNV---DPFPWQQKVRFAKGIASGMAYLH 443
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 52.0 bits (123), Expect = 1e-06 Identities = 33/129 (25%), Positives = 67/129 (51%), Gaps = 2/129 (1%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAK 310 + ++ F + KLG+G + VYKG +G+ +A+K ++ S +G E++L+ + Sbjct: 1 MTGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIREISLMKE 60 Query: 311 LKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGL 490 L H+N+V L V + + LV+EF+ ++ L + + LD + I + +G+ Sbjct: 61 LDHENIVTLYDVIHTENKLTLVFEFM-DKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGI 119 Query: 491 QYLHEDSQL 517 + H++ L Sbjct: 120 MFCHDNRVL 128
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 52.0 bits (123), Expect = 1e-06 Identities = 29/81 (35%), Positives = 51/81 (62%), Gaps = 3/81 (3%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 DF + K+G+G +G VYKG G+ +A+K++ +S +GV E++L+ +LKH+N Sbjct: 3 DFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHEN 62 Query: 326 LVRLVGVCLEQQERLLVYEFV 388 +V L V +E+ L++EF+ Sbjct: 63 IVCLEDVLMEENRIYLIFEFL 83
>M3K4_MOUSE (O08648) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 52.0 bits (123), Expect = 1e-06 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 3/95 (3%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKGTLPD-GEEIAVK--RLSKSSTQGVEELKNELALVA 307 LR T + NK+G+G +G VY D GE +A+K R + + ++E +EL + Sbjct: 1325 LRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFE 1384 Query: 308 KLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 412 +KH NLVR GV L ++E + E+ +L+++ Sbjct: 1385 GIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV 1419
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 52.0 bits (123), Expect = 1e-06 Identities = 28/81 (34%), Positives = 46/81 (56%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 ++G G FG V+ G + +++A+K + + + E+ E ++ KL H LV+L GVCL Sbjct: 373 EIGSGQFGLVHLGYWLNKDKVAIKTIQEGA-MSEEDFIEEAEVMMKLSHPKLVQLYGVCL 431 Query: 353 EQQERLLVYEFVPNRSLDQIL 415 EQ LV+EF+ + L L Sbjct: 432 EQAPICLVFEFMEHGCLSDYL 452
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 52.0 bits (123), Expect = 1e-06 Identities = 32/119 (26%), Positives = 67/119 (56%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 ++A+ K+G+G +G VYKG G+ +A+K++ ++ +GV E++L+ +L+H N Sbjct: 3 EYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLENEEEGVPSTAIREISLLKELQHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L+ V ++ L++EF+ + L + L G+ L+ + + I +G+ + H Sbjct: 63 IVCLLDVLMQDSRLYLIFEFL-SMDLKKYLDSIPSGQYLEAMLVKSYLYQILQGIIFCH 120
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 52.0 bits (123), Expect = 1e-06 Identities = 31/119 (26%), Positives = 66/119 (55%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 ++ + K+G+G +G VYKG G+ +A+K++ ++ +GV E++L+ +L+H N Sbjct: 3 EYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L+ V ++ L++EF+ + L + L G+ +D + + I +G+ + H Sbjct: 63 IVCLLDVLMQDSRLYLIFEFL-SMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCH 120
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 52.0 bits (123), Expect = 1e-06 Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 20/129 (15%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLV--G 343 LG GGFGAVYK T G +AVK++ KSS + ++ A VA+L+H N+VR+V Sbjct: 70 LGSGGFGAVYKATY-HGVTVAVKQVKKSSKNRLASRQSFWAELNVARLQHDNVVRVVAAS 128 Query: 344 VCLEQQERLL---VYEFVPNRSLDQILFDT----EKGEQLDWGMRHRIIR---------G 475 C + L + E+V N +L +++ T +GE+ + G + + Sbjct: 129 TCAPASQNSLGTIIMEYVGNVTLHHVIYGTRDAWRQGEEEEGGCGRKALSMAEAVCYSCD 188 Query: 476 IARGLQYLH 502 I GL +LH Sbjct: 189 IVTGLAFLH 197
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 52.0 bits (123), Expect = 1e-06 Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 271 DVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNI 330 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F KG L +++ A G++YL Sbjct: 331 VRLIGVCTQKQPIYIVMELV--QGGDFLSFLRSKGPHLKMKELIKMMENAAAGMEYL 385
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 51.6 bits (122), Expect = 1e-06 Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 4/117 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKS---STQGVEELKNELALVAKLKHKNLVRLVGV 346 +G G FG VYKG + + +A+KR + S V+ E++++ +L H +++ VG Sbjct: 468 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 526 Query: 347 CLEQQERL-LVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQ 514 CL + +V +++ SL +L E+ LD + I +ARG++YLH +Q Sbjct: 527 CLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVARGMEYLHNLTQ 581
>ANPRA_RAT (P18910) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 51.6 bits (122), Expect = 1e-06 Identities = 30/102 (29%), Positives = 53/102 (51%) Frame = +2 Query: 197 AVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLV 376 A YKG L +AVKR+++ + ++ EL + +++++L R VG C + ++ Sbjct: 553 AYYKGNL-----VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICIL 607 Query: 377 YEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 E+ P SL IL + LDW R+ + I +G+ +LH Sbjct: 608 TEYCPRGSLQDIL--ENESITLDWMFRYSLTNDIVKGMLFLH 647
>ANPRA_MOUSE (P18293) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 51.6 bits (122), Expect = 1e-06 Identities = 30/102 (29%), Positives = 53/102 (51%) Frame = +2 Query: 197 AVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLV 376 A YKG L +AVKR+++ + ++ EL + +++++L R VG C + ++ Sbjct: 553 AYYKGNL-----VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICIL 607 Query: 377 YEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 E+ P SL IL + LDW R+ + I +G+ +LH Sbjct: 608 TEYCPRGSLQDIL--ENESITLDWMFRYSLTNDIVKGMLFLH 647
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 51.6 bits (122), Expect = 1e-06 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 22/130 (16%) Frame = +2 Query: 176 LGQGGFGAVYKGTLP------DGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVR 334 +G+G FG V+ GT + +AVK L S + ++ + + E ++A ++H N+V Sbjct: 510 IGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIVT 569 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL---------------FDTEKGEQLDWGMRHRII 469 GVC E + ++++EF+ N L++ L D+++G QL +I+ Sbjct: 570 FYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDRDSMDSDEG-QLTREQLMKIV 628 Query: 470 RGIARGLQYL 499 IA ++YL Sbjct: 629 LQIASAMEYL 638
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 51.6 bits (122), Expect = 1e-06 Identities = 34/126 (26%), Positives = 64/126 (50%), Gaps = 5/126 (3%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +F KLG G FG V++G D ++A+K +S+ + + L++E+ + KL+HK+++ Sbjct: 190 EFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILA 249 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-----GEQLDWGMRHRIIRGIARGLQYL 499 L V ++ E + SL ++L D+++ E LD I +A G+ YL Sbjct: 250 LYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLD------IAWQVAEGMCYL 303 Query: 500 HEDSQL 517 + + Sbjct: 304 ESQNYI 309
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 51.6 bits (122), Expect = 1e-06 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + ++ A +A+L+H N+VR+V Sbjct: 98 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVA 156 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++ + EQL G + + G Sbjct: 157 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNG 216 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 217 LLFLHSQSIL 226
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 51.6 bits (122), Expect = 1e-06 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + ++ A +A+L+H N+VR+V Sbjct: 114 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVA 172 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++ + EQL G + + G Sbjct: 173 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNG 232 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 233 LLFLHSQSIL 242
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 51.6 bits (122), Expect = 1e-06 Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 4/117 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKS---STQGVEELKNELALVAKLKHKNLVRLVGV 346 +G G FG VYKG + + +A+KR + S V+ E++++ +L H +V+ VG Sbjct: 467 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 525 Query: 347 CLEQQERL-LVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQ 514 CL+ + +V +++ SL +L E+ LD + I +A+G++YLH +Q Sbjct: 526 CLDDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHSLTQ 580
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/118 (30%), Positives = 60/118 (50%), Gaps = 3/118 (2%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 +LG G FG V++G +AVK L K T VEE E +++ +L+H L++L VC Sbjct: 245 RLGAGQFGEVWEGLWNGTTSVAVKTL-KPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCT 303 Query: 353 EQQERLLVYEFVPNRSLDQILFDTE---KGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 +++ +V E + SL + L + K EQL + +A G+ YL + + + Sbjct: 304 KEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQL-----VDVAAQVASGMSYLEQQNYI 356
>ANPRA_HUMAN (P16066) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1061 Score = 51.6 bits (122), Expect = 1e-06 Identities = 30/102 (29%), Positives = 53/102 (51%) Frame = +2 Query: 197 AVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLV 376 A YKG L +AVKR+++ + ++ EL + +++++L R VG C + ++ Sbjct: 557 AYYKGNL-----VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICIL 611 Query: 377 YEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 E+ P SL IL + LDW R+ + I +G+ +LH Sbjct: 612 TEYCPRGSLQDIL--ENESITLDWMFRYSLTNDIVKGMLFLH 651
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/126 (28%), Positives = 62/126 (49%), Gaps = 5/126 (3%) Frame = +2 Query: 146 ATGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAKLKH 319 A F + K+G G + VYKG G +A+K + S +G E++L+ +LKH Sbjct: 3 APSQFKQLEKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 Query: 320 KNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ---LDWGMRHRIIRGIARGL 490 N+VRL V + + LV+EF+ N L + + + KG L+ + + +G+ Sbjct: 63 DNIVRLFDVIHTENKLTLVFEFMDN-DLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGV 121 Query: 491 QYLHED 508 + HE+ Sbjct: 122 AFCHEN 127
>7LESS_DROME (P13368) Protein sevenless (EC 2.7.10.1)| Length = 2554 Score = 51.6 bits (122), Expect = 1e-06 Identities = 30/74 (40%), Positives = 44/74 (59%), Gaps = 5/74 (6%) Frame = +2 Query: 176 LGQGGFGAVYKGTLP--DGEE---IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV 340 LG G FG VY+G L D EE +A+K L K +++ EL E L++ KH+N+V LV Sbjct: 2215 LGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASE-FAELLQEAQLMSNFKHENIVCLV 2273 Query: 341 GVCLEQQERLLVYE 382 G+C + + L+ E Sbjct: 2274 GICFDTESISLIME 2287
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 51.6 bits (122), Expect = 1e-06 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + ++ A +A+L+H N+VR+V Sbjct: 98 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVA 156 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++ + EQL G + + G Sbjct: 157 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNG 216 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 217 LLFLHSQSIL 226
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 51.6 bits (122), Expect = 1e-06 Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 4/117 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKS---STQGVEELKNELALVAKLKHKNLVRLVGV 346 +G G FG VYKG + + +A+KR + S V+ E++++ +L H +V+ VG Sbjct: 468 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 526 Query: 347 CLEQQERL-LVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQ 514 CL+ + +V +++ SL +L E+ LD + I +A+G++YLH +Q Sbjct: 527 CLDDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHSLTQ 581
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 51.6 bits (122), Expect = 1e-06 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + ++ A +A+L+H N+VR+V Sbjct: 67 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVA 125 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++ + EQL G + + G Sbjct: 126 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNG 185 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 186 LLFLHSQSIL 195
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 51.2 bits (121), Expect = 2e-06 Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 4/121 (3%) Frame = +2 Query: 152 GDFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQG---VEELKNELALVAKLKH 319 G+F +G+G FGAV +GT + G ++A+K L++ +G V + +NE+ + KL H Sbjct: 22 GNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTH 81 Query: 320 KNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 ++ RL V + LV E V L + T KG L R + I G+ Y Sbjct: 82 PHITRLFRVISTPSDIFLVMELVSGGEL--FSYITRKG-ALPIRESRRYFQQIISGVSYC 138 Query: 500 H 502 H Sbjct: 139 H 139
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 51.2 bits (121), Expect = 2e-06 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + ++ A +A L+H N+VR+V Sbjct: 78 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTEDLRASQRSFWAELNIAGLRHDNIVRVVA 136 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++D + +QL G + + G Sbjct: 137 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVVNG 196 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 197 LLFLHSQSIL 206
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 51.2 bits (121), Expect = 2e-06 Identities = 39/126 (30%), Positives = 68/126 (53%), Gaps = 9/126 (7%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEE----IAVKRLSK-SSTQGVEELKNELALVAKLK 316 +F + LG G FG VYKG +P+GE+ +A+K L + +S + +E+ +E ++A + Sbjct: 131 EFKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 190 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARG 487 + ++ RL+G+CL +L+ LD I + G Q L+W ++ IA+G Sbjct: 191 NPHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQ------IAKG 244 Query: 488 LQYLHE 505 + YL E Sbjct: 245 MNYLEE 250
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 51.2 bits (121), Expect = 2e-06 Identities = 37/122 (30%), Positives = 61/122 (50%), Gaps = 8/122 (6%) Frame = +2 Query: 167 SNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGV 346 + KLG G FG V+ G + ++AVK L K T +E ++ KL+HK+LV+L + Sbjct: 243 NRKLGAGQFGEVWAGVWNNTTQVAVKTL-KPGTMSPASFLDEAGVMKKLRHKHLVQLYAI 301 Query: 347 CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDW------GMRHRIIRGIA--RGLQYLH 502 C +++ +V E++ SL L KGE ++ M ++ G+A Y+H Sbjct: 302 CSDREPIYIVTEYMSGGSLLDYL---SKGEGVNLQLPTLIDMAAQVASGMAFLEAQGYIH 358 Query: 503 ED 508 D Sbjct: 359 RD 360
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 51.2 bits (121), Expect = 2e-06 Identities = 40/147 (27%), Positives = 66/147 (44%), Gaps = 3/147 (2%) Frame = +2 Query: 71 PSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRL 250 P ++ GK + D L T + +E LG G GAV+ G EE+A+K++ Sbjct: 140 PVWNIIGK-AYATDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFR-AEEVAIKKV 197 Query: 251 SKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK 430 + + ++ L+ KLKH N++ GVC + ++ E+ + L ++L K Sbjct: 198 REQNETDIKHLR-------KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK 250 Query: 431 GEQ---LDWGMRHRIIRGIARGLQYLH 502 +DW GIA G+ YLH Sbjct: 251 ITPRLLVDWS------TGIASGMNYLH 271
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 9/102 (8%) Frame = +2 Query: 125 DISTLRAATGDFAESNKL-GQGGFGAVYKGT----LPDG---EEIAVKRLSKSST-QGVE 277 +I +L A D +KL G G FG VY+GT L DG +AVK L + +T Q Sbjct: 86 EIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKS 145 Query: 278 ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 E E L++K H ++++L+GVCL + + L+ E + L Sbjct: 146 EFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDL 187
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase| 1) (JAK-1) Length = 1153 Score = 51.2 bits (121), Expect = 2e-06 Identities = 41/144 (28%), Positives = 68/144 (47%), Gaps = 11/144 (7%) Frame = +2 Query: 119 LMDISTLRAATGDFAESNKLGQGGFGAVYKGTL---PDGEEIAVKRLSKSSTQGVEELKN 289 + +S R D + LG+G +Y GTL D E IA ++ K + ++ Sbjct: 569 MSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHR 628 Query: 290 ELAL--------VAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLD 445 +++L + ++ HK++V L GVC+ E ++V EFV LD LF K + L Sbjct: 629 DISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLD--LFMHRKSDALT 686 Query: 446 WGMRHRIIRGIARGLQYLHEDSQL 517 + ++ + +A L YL ED L Sbjct: 687 TPWKFKVAKQLASALSYL-EDKDL 709 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 8/116 (6%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPD-----GEEIAVKRLS-KSSTQGVEELKNELALVAKLKHKNLVRL 337 LG+G FG V GE++AVK L +S + +LK E+ ++ L H+N+V+ Sbjct: 880 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 939 Query: 338 VGVCLEQQER--LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 G+C+E L+ EF+P+ SL + L + L +++ I I +G+ YL Sbjct: 940 KGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAI--QICKGMDYL 993
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 51.2 bits (121), Expect = 2e-06 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 14/130 (10%) Frame = +2 Query: 170 NKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLVG 343 ++LG GGFG+VYK T G +A+K+++K + ++ A +A L+H N+VR+V Sbjct: 98 HRLGSGGFGSVYKATY-HGVPVAIKQVNKCTEDLRASQRSFWAELNIAGLRHDNIVRVVA 156 Query: 344 VCLEQQE-----RLLVYEFVPNRSLDQILFDTEKG-------EQLDWGMRHRIIRGIARG 487 E ++ EF N +L Q+++D + +QL G + + G Sbjct: 157 ASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVVNG 216 Query: 488 LQYLHEDSQL 517 L +LH S L Sbjct: 217 LLFLHSQSIL 226
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 51.2 bits (121), Expect = 2e-06 Identities = 41/165 (24%), Positives = 72/165 (43%), Gaps = 7/165 (4%) Frame = +2 Query: 29 RRRRRSPAQANQPYPSYSTE----GKDTESVDSMLMDISTLRAATG--DFAESNKLGQGG 190 R RRS + + P PS E +D +S+ S + D LG+G Sbjct: 282 RSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGF 341 Query: 191 FGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQER 367 FG K T G+ + +K L + + + E+ ++ L H N+++ +GV + ++ Sbjct: 342 FGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKL 401 Query: 368 LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 L+ E++ +L L + W + R +GIA G+ YLH Sbjct: 402 NLLTEYIEGGTLKDFL---RSMDPFPWQQKVRFAKGIASGMAYLH 443
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 51.2 bits (121), Expect = 2e-06 Identities = 39/146 (26%), Positives = 68/146 (46%), Gaps = 1/146 (0%) Frame = +2 Query: 83 TEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSS 262 TEG + D +D ++L+ KLG G FG V++G + +A+K L KS Sbjct: 230 TEGLSHRTRDQWEIDRTSLKFV-------RKLGSGQFGDVWEGLWNNTTPVAIKTL-KSG 281 Query: 263 TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LDQILFDTEKGEQ 439 T ++ E ++ KL+H L++L VC ++ ++ E + + S L+ + KG Sbjct: 282 TMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRS 341 Query: 440 LDWGMRHRIIRGIARGLQYLHEDSQL 517 L + IA G+ YL + + Sbjct: 342 LKMQTLIDMAAQIAAGMAYLESQNYI 367
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 9/102 (8%) Frame = +2 Query: 125 DISTLRAATGDFAESNKL-GQGGFGAVYKGT----LPDG---EEIAVKRLSKSST-QGVE 277 +I +L A D +KL G G FG VY+GT L DG +AVK L + +T Q Sbjct: 1949 EIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKS 2008 Query: 278 ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 E E L++K H ++++L+GVCL + + L+ E + L Sbjct: 2009 EFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDL 2050
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 51.2 bits (121), Expect = 2e-06 Identities = 37/128 (28%), Positives = 67/128 (52%), Gaps = 8/128 (6%) Frame = +2 Query: 149 TGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAKLKHK 322 + F + KLG+G + VYKG G+ +A+K ++ S +G E++L+ +LKH+ Sbjct: 4 SSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIREISLMKELKHE 63 Query: 323 NLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKG----EQLDWGMRHRIIRGI--AR 484 N+V L V + + LV+E++ + + KG +Q+ W M ++++RGI Sbjct: 64 NIVTLYDVIHTENKLNLVFEYMDKDLKKFMDTNGNKGALETKQVKWFM-YQLLRGILFCH 122 Query: 485 GLQYLHED 508 + LH D Sbjct: 123 DNRVLHRD 130
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 50.8 bits (120), Expect = 2e-06 Identities = 47/166 (28%), Positives = 76/166 (45%), Gaps = 13/166 (7%) Frame = +2 Query: 44 SPAQANQPYP--SYSTEGKDTESVDSMLMD--ISTLRAATGDFAESNKLGQGGFGAVYKG 211 SP+ QP P ST +DT +++ D I +R A +G G FG VY G Sbjct: 360 SPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGAL--------IGSGSFGQVYLG 411 Query: 212 -TLPDGEEIAVKRLSKSSTQG--------VEELKNELALVAKLKHKNLVRLVGVCLEQQE 364 GE +AVK++ S ++ L E+AL+ +L H+++V+ +G L Sbjct: 412 MNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDH 471 Query: 365 RLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + E+VP S+ +L E+ + I+ +GL+YLH Sbjct: 472 LNIFLEYVPGGSVAGLLTMYGSFEET---LVKNFIKQTLKGLEYLH 514
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/114 (28%), Positives = 57/114 (50%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 LG G FG V++G +AVK L K T +EE E +++ +L+H L++L VC + Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTL-KPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTK 304 Query: 356 QQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 ++ +V E + + SL + L G L + +A G+ YL + + + Sbjct: 305 EEPIYIVTELMKHGSLLEYL--RGDGRSLKLPDLVDMCSQVASGMSYLEQQNYI 356
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 5/122 (4%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAKLKHKNLV 331 F + +LG G + VYKG G +A+K + S +G E++L+ +LKH+N+V Sbjct: 9 FKQLERLGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 68 Query: 332 RLVGVCLEQQERLLVYEFVPN---RSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 RL V + + LV+EF+ N + +D L D E L+ + + +G+ + H Sbjct: 69 RLYDVIHTENKLTLVFEFMDNDLKKFMDSRL-DREMPRGLELSLVKYFQWQLLQGVAFCH 127 Query: 503 ED 508 E+ Sbjct: 128 EN 129
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 347 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNI 406 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F +G +L +++ A G++YL Sbjct: 407 VRLIGVCTQKQPIYIVMELV--QGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYL 461
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 77/164 (46%), Gaps = 5/164 (3%) Frame = +2 Query: 26 WRRRRRSPAQ---ANQPYPSYSTEGKDTESVDSMLMDISTLRAATGDFAESNKLGQGGFG 196 +R R RSP + A +P P +D E + + +F K+G G FG Sbjct: 447 FRNRSRSPGERLDAQRPRPPQKPHHEDWEILPN-------------EFIIQYKVGSGSFG 493 Query: 197 AVYKGTLPDGEEIAVKRLS--KSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERL 370 VY+G +A+K+L+ + + KNE+A++ K +H N++ +G + + E Sbjct: 494 TVYRGEF--FGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMG-WVREPEIA 550 Query: 371 LVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 ++ ++ SL + + E + + G I++ ++ G+ YLH Sbjct: 551 IITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLH 594
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 558 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNI 617 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F +G +L +++ A G++YL Sbjct: 618 VRLIGVCTQKQPIYIVMELV--QGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYL 672
>UFO_HUMAN (P30530) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (AXL oncogene) Length = 887 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/122 (29%), Positives = 63/122 (51%), Gaps = 14/122 (11%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEI---AVK--RLSKSSTQGVEELKNELALVAKLKHKNLVRLV 340 LG+G FGAV +G L + I AVK +++ + +E+ +E + + H N++RL+ Sbjct: 535 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 594 Query: 341 GVCLEQQER------LLVYEFVPNRSLDQILFDTEKGEQ---LDWGMRHRIIRGIARGLQ 493 GVC + ER +++ F+ + L L + G+Q L M + + IA G++ Sbjct: 595 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 654 Query: 494 YL 499 YL Sbjct: 655 YL 656
>ANPRB_RAT (P16067) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 50.8 bits (120), Expect = 2e-06 Identities = 25/93 (26%), Positives = 47/93 (50%) Frame = +2 Query: 224 GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 G +A+K ++K + ++ EL + ++ +L R +G C++ +V E+ P SL Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 404 DQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 IL LDW R+ +I + +G+ +LH Sbjct: 605 QDIL--ENDSINLDWMFRYSLINDLVKGMAFLH 635
>ANPRB_MOUSE (Q6VVW5) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 50.8 bits (120), Expect = 2e-06 Identities = 25/93 (26%), Positives = 47/93 (50%) Frame = +2 Query: 224 GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 G +A+K ++K + ++ EL + ++ +L R +G C++ +V E+ P SL Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 404 DQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 IL LDW R+ +I + +G+ +LH Sbjct: 605 QDIL--ENDSINLDWMFRYSLINDLVKGMAFLH 635
>ANPRB_HUMAN (P20594) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 50.8 bits (120), Expect = 2e-06 Identities = 25/93 (26%), Positives = 47/93 (50%) Frame = +2 Query: 224 GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 G +A+K ++K + ++ EL + ++ +L R +G C++ +V E+ P SL Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 404 DQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 IL LDW R+ +I + +G+ +LH Sbjct: 605 QDIL--ENDSINLDWMFRYSLINDLVKGMAFLH 635
>ANPRB_BOVIN (P46197) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 50.8 bits (120), Expect = 2e-06 Identities = 25/93 (26%), Positives = 47/93 (50%) Frame = +2 Query: 224 GEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 403 G +A+K ++K + ++ EL + ++ +L R +G C++ +V E+ P SL Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 404 DQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 IL LDW R+ +I + +G+ +LH Sbjct: 605 QDIL--ENDSINLDWMFRYSLINDLVKGMAFLH 635
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 50.8 bits (120), Expect = 2e-06 Identities = 37/115 (32%), Positives = 60/115 (52%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEE--IAVKRLSKSST-QGVEELKNELALVAKLKHKNLVRLV 340 +G G FG V G L P E +A+K L T + E +E +++ + +H N++ L Sbjct: 643 IGSGEFGEVCFGRLKHPGKREYTVAIKTLKSGYTDEQRREFLSEASIMGQFEHPNVIHLE 702 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + ++V EF+ N SLD L +K Q ++RGIA G++YL + Sbjct: 703 GVVTKSRPVMIVTEFMENGSLDSFL--RQKEGQFSVLQLVGMLRGIAAGMRYLSD 755
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/85 (38%), Positives = 49/85 (57%), Gaps = 9/85 (10%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPD------GE-EIAVKRLSKSST--QGVEELKNELALVAKLKHKNL 328 LG G FG VY+GT D GE ++AVK L K ST + +E LK E L++K H N+ Sbjct: 1951 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLK-EAHLMSKFNHPNI 2009 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSL 403 ++ +GVCL + + ++ E + L Sbjct: 2010 LKQLGVCLLNEPQYIILELMEGGDL 2034
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 50.8 bits (120), Expect = 2e-06 Identities = 38/126 (30%), Positives = 68/126 (53%), Gaps = 9/126 (7%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEE----IAVKRLSK-SSTQGVEELKNELALVAKLK 316 +F + LG G FG +YKG +P+GE+ +A+K L + +S + +E+ +E ++A + Sbjct: 131 EFKKVKVLGSGAFGTIYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 190 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARG 487 + ++ RL+G+CL +L+ LD I + G Q L+W ++ IA+G Sbjct: 191 NPHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQ------IAKG 244 Query: 488 LQYLHE 505 + YL E Sbjct: 245 MNYLEE 250
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 50.8 bits (120), Expect = 2e-06 Identities = 34/118 (28%), Positives = 60/118 (50%), Gaps = 4/118 (3%) Frame = +2 Query: 161 AESNKLGQGGFGAVYKGTLPDGE-EIAVKRLSKSSTQGVEELKN---ELALVAKLKHKNL 328 A+ L +G G V D ++AVK L + E K+ E ++ K + + Sbjct: 19 ADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYI 78 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + ++G+C E + +V E++PN SL+++L + + W +R RI+ IA G+ YLH Sbjct: 79 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 136
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/148 (24%), Positives = 70/148 (47%), Gaps = 5/148 (3%) Frame = +2 Query: 74 SYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT-LPDGEEIA 238 S + K + D +M+ + GD + K+GQG G V+ T + G+E+A Sbjct: 217 SSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVA 276 Query: 239 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 418 +K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL ++ Sbjct: 277 IKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVT 336 Query: 419 DTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +T +D + R + L++LH Sbjct: 337 ET----CMDEAQIAAVCRECLQALEFLH 360
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/148 (24%), Positives = 70/148 (47%), Gaps = 5/148 (3%) Frame = +2 Query: 74 SYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT-LPDGEEIA 238 S + K + D +M+ + GD + K+GQG G V+ T + G+E+A Sbjct: 217 SSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVA 276 Query: 239 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 418 +K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL ++ Sbjct: 277 IKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVT 336 Query: 419 DTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +T +D + R + L++LH Sbjct: 337 ET----CMDEAQIAAVCRECLQALEFLH 360
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/148 (24%), Positives = 70/148 (47%), Gaps = 5/148 (3%) Frame = +2 Query: 74 SYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT-LPDGEEIA 238 S + K + D +M+ + GD + K+GQG G V+ T + G+E+A Sbjct: 217 SLDKQKKKPKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVA 276 Query: 239 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 418 +K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL ++ Sbjct: 277 IKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVT 336 Query: 419 DTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +T +D + R + L++LH Sbjct: 337 ET----CMDEAQIAAVCRECLQALEFLH 360
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 50.8 bits (120), Expect = 2e-06 Identities = 30/119 (25%), Positives = 66/119 (55%), Gaps = 3/119 (2%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHKN 325 ++ + K+G+G +G VYKG G+ +A+K++ ++ +GV E++L+ +L+H N Sbjct: 3 EYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPN 62 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 +V L+ V ++ L++EF+ + + + L G+ +D + + I +G+ + H Sbjct: 63 IVCLLDVLMQDSRLYLIFEFL-SMDVKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCH 120
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 215 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNI 274 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F +G +L +++ A G++YL Sbjct: 275 VRLIGVCTQKQPIYIVMELV--QGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYL 329
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 50.8 bits (120), Expect = 2e-06 Identities = 38/129 (29%), Positives = 66/129 (51%), Gaps = 2/129 (1%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSK--SSTQGVEELKNEL 295 M ++ ++ + DF ES +L GGFG V + +K + K + + E L E Sbjct: 5 MSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEA 64 Query: 296 ALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRG 475 ++ +L+H +V+L+GV +E+ + LV E++ +L +L E L ++ RII Sbjct: 65 KMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVL-KAEMSTPL--SVKGRIILE 121 Query: 476 IARGLQYLH 502 I G+ YLH Sbjct: 122 IIEGMCYLH 130
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 7/135 (5%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 +D+S LR G F +G G +G VYKG ++A ++ + EE+K E+ + Sbjct: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72 Query: 302 VAKLK-HKNLVRLVGVCLEQ------QERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRH 460 + K H+N+ G +++ + LV EF S+ ++ +T KG L Sbjct: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT-KGNTLKEEWIA 131 Query: 461 RIIRGIARGLQYLHE 505 I R I RGL +LH+ Sbjct: 132 YICREILRGLSHLHQ 146
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 50.4 bits (119), Expect = 3e-06 Identities = 40/165 (24%), Positives = 71/165 (43%), Gaps = 7/165 (4%) Frame = +2 Query: 29 RRRRRSPAQANQPYPSYSTE----GKDTESVDSMLMDISTLRAATG--DFAESNKLGQGG 190 R RRS + + P PS E +D +S+ S + D LG+G Sbjct: 282 RSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRSSSSCSQQIFRPCDLIHGEVLGKGF 341 Query: 191 FGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQER 367 FG K T G+ + +K L + + + E+ ++ L H N+++ +GV + ++ Sbjct: 342 FGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKL 401 Query: 368 LLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 L+ E++ +L L + W + +GIA G+ YLH Sbjct: 402 NLLTEYIEGGTLKDFL---RNADPFPWQQKVSFAKGIASGMAYLH 443
>MERTK_HUMAN (Q12866) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 999 Score = 50.4 bits (119), Expect = 3e-06 Identities = 37/126 (29%), Positives = 65/126 (51%), Gaps = 18/126 (14%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGE----EIAVK--RLSKSSTQGVEELKNELALVAKLKHKNLVRL 337 LG+G FG+V +G L + ++AVK +L SS + +EE +E A + H N++RL Sbjct: 593 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIRL 652 Query: 338 VGVCLEQQER-----LLVYEFVPNRSLDQILFDTEKGEQLDWGMRH-------RIIRGIA 481 +GVC+E + +++ F+ L L + +L+ G +H + + IA Sbjct: 653 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS----RLETGPKHIPLQTLLKFMVDIA 708 Query: 482 RGLQYL 499 G++YL Sbjct: 709 LGMEYL 714
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/158 (22%), Positives = 74/158 (46%), Gaps = 5/158 (3%) Frame = +2 Query: 50 AQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT- 214 A ++ Y + + K ++ D +++ + GD + K+GQG G VY Sbjct: 228 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 287 Query: 215 LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN 394 + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E +V E++ Sbjct: 288 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 347 Query: 395 RSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 SL ++ +T +D G + R + L +LH + Sbjct: 348 GSLTDVVTET----CMDEGQIAAVCRECLQALDFLHSN 381
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/165 (23%), Positives = 73/165 (44%), Gaps = 10/165 (6%) Frame = +2 Query: 44 SPAQANQPYPSYSTEGKDTESVDSMLMDISTLR-----AATGD----FAESNKLGQGGFG 196 SP + N P T + + + D L + GD + K+GQG G Sbjct: 222 SPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASG 281 Query: 197 AVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLL 373 VY + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E + Sbjct: 282 TVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWV 341 Query: 374 VYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 V E++ SL ++ +T +D G + R + L++LH + Sbjct: 342 VMEYLAGGSLTDVVTET----CMDEGQIAAVCRECLQALEFLHSN 382
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 50.4 bits (119), Expect = 3e-06 Identities = 34/117 (29%), Positives = 62/117 (52%), Gaps = 4/117 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKS---STQGVEELKNELALVAKLKHKNLVRLVGV 346 +G G FG VYKG + + +A+KR + S V+ E++++ +L H +++ VG Sbjct: 570 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 628 Query: 347 CLEQQERL-LVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQ 514 CL + +V +++ SL +L E+ LD + I +A+G++YLH +Q Sbjct: 629 CLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHNLTQ 683
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/158 (22%), Positives = 74/158 (46%), Gaps = 5/158 (3%) Frame = +2 Query: 50 AQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT- 214 A ++ Y + + K ++ D +++ + GD + K+GQG G VY Sbjct: 243 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302 Query: 215 LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN 394 + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E +V E++ Sbjct: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362 Query: 395 RSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 SL ++ +T +D G + R + L +LH + Sbjct: 363 GSLTDVVTET----CMDEGQIAAVCRECLQALDFLHSN 396
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/158 (22%), Positives = 74/158 (46%), Gaps = 5/158 (3%) Frame = +2 Query: 50 AQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT- 214 A ++ Y + + K ++ D +++ + GD + K+GQG G VY Sbjct: 243 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302 Query: 215 LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN 394 + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E +V E++ Sbjct: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362 Query: 395 RSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 SL ++ +T +D G + R + L +LH + Sbjct: 363 GSLTDVVTET----CMDEGQIAAVCRECLQALDFLHSN 396
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/158 (22%), Positives = 74/158 (46%), Gaps = 5/158 (3%) Frame = +2 Query: 50 AQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT- 214 A ++ Y + + K ++ D +++ + GD + K+GQG G VY Sbjct: 243 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302 Query: 215 LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN 394 + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E +V E++ Sbjct: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362 Query: 395 RSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 SL ++ +T +D G + R + L +LH + Sbjct: 363 GSLTDVVTET----CMDEGQIAAVCRECLQALDFLHSN 396
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 50.4 bits (119), Expect = 3e-06 Identities = 41/173 (23%), Positives = 75/173 (43%), Gaps = 7/173 (4%) Frame = +2 Query: 5 HEAGLFIWRRRRRSPAQANQPYPSYSTE----GKDTESVDSMLMDISTLRAATG--DFAE 166 ++ G R RRS + + P PS E +D +S+ S + D Sbjct: 274 NQEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIH 333 Query: 167 SNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVG 343 LG+G FG K T G+ + +K L + + + E+ ++ L H N+++ +G Sbjct: 334 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 V + ++ L+ E++ +L L + W + R +GI+ G+ YLH Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFL---RSVDPFPWQQKVRFAKGISSGMAYLH 443
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 50.4 bits (119), Expect = 3e-06 Identities = 32/118 (27%), Positives = 63/118 (53%), Gaps = 3/118 (2%) Frame = +2 Query: 173 KLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQ-GVE-ELKNELALVAKLKHKNLVRLVG 343 K+G+G +G VY+ + +A+KR+ S + GV E++++ +L+H+N+VRL+ Sbjct: 10 KIGEGSYGVVYRARDITTDVIVALKRIRLESVEEGVPCTAIREISILKELRHENIVRLLD 69 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHEDSQL 517 VC + LV+E++ +D + LD +R + +G+++ HE + L Sbjct: 70 VCHSENRLNLVFEYM---EMDLKKYMDRASGNLDPATIQEFMRSLLKGVRFCHERNVL 124
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 7/135 (5%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 +D+S LR G F +G G +G VYKG ++A ++ + EE+K E+ + Sbjct: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72 Query: 302 VAKLK-HKNLVRLVGVCLEQ------QERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRH 460 + K H+N+ G +++ + LV EF S+ ++ +T KG L Sbjct: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT-KGNTLKEEWIA 131 Query: 461 RIIRGIARGLQYLHE 505 I R I RGL +LH+ Sbjct: 132 YICREILRGLSHLHQ 146
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/165 (23%), Positives = 73/165 (44%), Gaps = 10/165 (6%) Frame = +2 Query: 44 SPAQANQPYPSYSTEGKDTESVDSMLMDISTLR-----AATGD----FAESNKLGQGGFG 196 SP + N P T + + + D L + GD + K+GQG G Sbjct: 223 SPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASG 282 Query: 197 AVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLL 373 VY + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E + Sbjct: 283 TVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWV 342 Query: 374 VYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 V E++ SL ++ +T +D G + R + L++LH + Sbjct: 343 VMEYLAGGSLTDVVTET----CMDEGQIAAVCRECLQALEFLHSN 383
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 50.1 bits (118), Expect = 4e-06 Identities = 32/90 (35%), Positives = 46/90 (51%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 KLG G FG V+ G + ++AVK L K T V+ E L+ L+H LVRL V Sbjct: 251 KLGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVT 309 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQL 442 +++ ++ EF+ SL L E G+ L Sbjct: 310 KEEPIYIITEFMAKGSLLDFLKSDEGGKVL 339
>MOS_VULGR (Q90XV7) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 50.1 bits (118), Expect = 4e-06 Identities = 41/129 (31%), Positives = 64/129 (49%), Gaps = 20/129 (15%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLV--G 343 LG GGFG+VYK T G +AVK++ KSS + ++ A VA+L+H N+VR+V Sbjct: 8 LGSGGFGSVYKATY-HGATVAVKQVKKSSKNRLASRQSFWAELNVARLQHNNVVRVVAAS 66 Query: 344 VCLEQQERLL---VYEFVPNRSLDQILFDT----EKGEQLDWGMRHRIIR---------G 475 C + L + E+V N +L +++ T +GE + G + + Sbjct: 67 TCAPASQNSLGTIIMEYVGNITLHHVIYGTGDAWRQGEDDEGGCGRKALSMEETVCYSCD 126 Query: 476 IARGLQYLH 502 I GL +LH Sbjct: 127 IMTGLAFLH 135
>MOS_GYMCA (Q90XV6) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 50.1 bits (118), Expect = 4e-06 Identities = 41/129 (31%), Positives = 64/129 (49%), Gaps = 20/129 (15%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLV--G 343 LG GGFG+VYK T G +AVK++ KSS + ++ A VA+L+H N+VR+V Sbjct: 8 LGSGGFGSVYKATY-HGATVAVKQVKKSSKNRLASRQSFWAELNVARLQHNNVVRVVAAS 66 Query: 344 VCLEQQERLL---VYEFVPNRSLDQILFDT----EKGEQLDWGMRHRIIR---------G 475 C + L + E+V N +L +++ T +GE + G + + Sbjct: 67 TCAPASQNSLGTIIMEYVGNITLHHVIYGTGDVWRQGEDDEGGCGRKALSMEETVCYSCD 126 Query: 476 IARGLQYLH 502 I GL +LH Sbjct: 127 IMTGLAFLH 135
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 50.1 bits (118), Expect = 4e-06 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 4/105 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPD-GEEIAVKRLSKSSTQGVEE--LKNELALVAKLKHKNLVRLVGV 346 +G+G +G V K D G +A+K+ +S + + E+ L+ +L+H+NLV L+ V Sbjct: 10 VGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEV 69 Query: 347 CLEQQERLLVYEFVPNRSLDQI-LFDTEKGEQLDWGMRHRIIRGI 478 C +++ LV+EFV + LD + LF +Q+ +II GI Sbjct: 70 CKKKKRWYLVFEFVDHTILDDLELFPNGLDDQVVQKYLFQIINGI 114
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 50.1 bits (118), Expect = 4e-06 Identities = 35/117 (29%), Positives = 57/117 (48%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +FA KLG+G FG V++G +A+K + KS+ + +L E+ + L+H+ L+R Sbjct: 229 EFALGRKLGEGYFGEVWEGLWLGSLPVAIKVI-KSANMKLTDLAKEIQTLKGLRHERLIR 287 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 L VC + +V E + +L Q T +G L +A G+ YL E Sbjct: 288 LHAVCSGGEPVYIVTELMRKGNL-QAFLGTPEGRALRLPPLLGFACQVAEGMSYLEE 343
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 50.1 bits (118), Expect = 4e-06 Identities = 33/120 (27%), Positives = 62/120 (51%), Gaps = 3/120 (2%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGTLPDGEE-IAVKRLSK--SSTQGVEELKNELALVAKLKHKNL 328 +A S+ +GQG FG VYK T D + +A+K +SK +T+ ++ L+ E + A+LKH ++ Sbjct: 4 YAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHV 63 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 + ++ + + +V EF + ++ GE+ R+ + L YLH + Sbjct: 64 IEMIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEE----PARRVTGHLVSALYYLHSN 119
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 50.1 bits (118), Expect = 4e-06 Identities = 35/119 (29%), Positives = 59/119 (49%), Gaps = 4/119 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVE---ELKNELALVAKLKHKN 325 F + +++G G FGAVY T E +AVK++S S Q E ++ E+ + +LKH N Sbjct: 24 FIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQTHEKWQDILKEVKFLQQLKHPN 83 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + G L++ LV E+ + D + + ++++ I G +GL YLH Sbjct: 84 TIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AITHGALQGLAYLH 139
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 50.1 bits (118), Expect = 4e-06 Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 F + ++G G FGAVY + E +A+K++S K ST+ +++ E+ + ++KH N Sbjct: 28 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 + G L + LV E+ + D + + ++++ I G +GL YLH Sbjct: 88 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AITHGALQGLAYLHS 144 Query: 506 DSQL 517 + + Sbjct: 145 HTMI 148
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 50.1 bits (118), Expect = 4e-06 Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 F + ++G G FGAVY + E +A+K++S K ST+ +++ E+ + ++KH N Sbjct: 28 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 + G L + LV E+ + D + + ++++ I G +GL YLH Sbjct: 88 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AITHGALQGLAYLHS 144 Query: 506 DSQL 517 + + Sbjct: 145 HTMI 148
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 50.1 bits (118), Expect = 4e-06 Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 F + ++G G FGAVY + E +A+K++S K ST+ +++ E+ + ++KH N Sbjct: 28 FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 + G L + LV E+ + D + + ++++ I G +GL YLH Sbjct: 88 SIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AITHGALQGLAYLHS 144 Query: 506 DSQL 517 + + Sbjct: 145 HTMI 148
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 50.1 bits (118), Expect = 4e-06 Identities = 36/158 (22%), Positives = 73/158 (46%), Gaps = 5/158 (3%) Frame = +2 Query: 50 AQANQPYPSYSTEGKDTESVDSMLMDISTLRAATGD----FAESNKLGQGGFGAVYKGT- 214 A + Y + + K ++ D +++ + GD + K+GQG G VY Sbjct: 243 ANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302 Query: 215 LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN 394 + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E +V E++ Sbjct: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362 Query: 395 RSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 SL ++ +T +D G + R + L +LH + Sbjct: 363 GSLTDVVTET----CMDEGQIAAVCRECLQALDFLHSN 396
>TAOK2_MOUSE (Q6ZQ29) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1055 Score = 50.1 bits (118), Expect = 4e-06 Identities = 31/124 (25%), Positives = 63/124 (50%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 F++ ++G G FGAVY + + E +A+K++S K S + +++ E+ + KL+H N Sbjct: 28 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 ++ G L + LV E+ + D + + ++++ + G +GL YLH Sbjct: 88 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AVTHGALQGLAYLHS 144 Query: 506 DSQL 517 + + Sbjct: 145 HNMI 148
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 50.1 bits (118), Expect = 4e-06 Identities = 40/130 (30%), Positives = 71/130 (54%), Gaps = 9/130 (6%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEE----IAVKRLSK-SSTQGVEELKNELALVAKLK 316 +F + LG G FG VYKG +P+GE+ +A+K L + +S + +E+ +E ++A + Sbjct: 713 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 772 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARG 487 + ++ RL+G+CL +L+ LD + + G Q L+W ++ IA+G Sbjct: 773 NPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQ------IAKG 826 Query: 488 LQYLHEDSQL 517 + YL ED +L Sbjct: 827 MNYL-EDRRL 835
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 50.1 bits (118), Expect = 4e-06 Identities = 31/124 (25%), Positives = 63/124 (50%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 F++ ++G G FGAVY + + E +A+K++S K S + +++ E+ + KL+H N Sbjct: 28 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 ++ G L + LV E+ + D + + ++++ + G +GL YLH Sbjct: 88 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AVTHGALQGLAYLHS 144 Query: 506 DSQL 517 + + Sbjct: 145 HNMI 148
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 50.1 bits (118), Expect = 4e-06 Identities = 31/124 (25%), Positives = 63/124 (50%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVY-KGTLPDGEEIAVKRLS---KSSTQGVEELKNELALVAKLKHKN 325 F++ ++G G FGAVY + + E +A+K++S K S + +++ E+ + KL+H N Sbjct: 28 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 87 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 ++ G L + LV E+ + D + + ++++ + G +GL YLH Sbjct: 88 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AVTHGALQGLAYLHS 144 Query: 506 DSQL 517 + + Sbjct: 145 HNMI 148
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 50.1 bits (118), Expect = 4e-06 Identities = 30/82 (36%), Positives = 45/82 (54%), Gaps = 3/82 (3%) Frame = +2 Query: 176 LGQGGFGAVYKG-TLPDGEEIAVKR--LSKSSTQGVEELKNELALVAKLKHKNLVRLVGV 346 LG+G FGAVY+G + +GE +AVK+ LSK + +K E+ L+ L H N+V+ G Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 347 CLEQQERLLVYEFVPNRSLDQI 412 ++ E+ N SL I Sbjct: 75 YQTNDSLCIILEYCENGSLRSI 96
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 50.1 bits (118), Expect = 4e-06 Identities = 39/126 (30%), Positives = 68/126 (53%), Gaps = 9/126 (7%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEE----IAVKRLSK-SSTQGVEELKNELALVAKLK 316 +F + LG G FG VYKG +P+GE+ +A+K L + +S + +E+ +E ++A + Sbjct: 131 EFKKVKVLGFGAFGTVYKGLWIPEGEKVTIPVAIKELREATSPKANKEILDEAYVMASVD 190 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARG 487 + ++ RL+G+CL +L+ LD I + G Q L+W ++ IA+G Sbjct: 191 NPHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQ------IAKG 244 Query: 488 LQYLHE 505 + YL E Sbjct: 245 MNYLEE 250
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 50.1 bits (118), Expect = 4e-06 Identities = 39/165 (23%), Positives = 73/165 (44%), Gaps = 10/165 (6%) Frame = +2 Query: 44 SPAQANQPYPSYSTEGKDTESVDSMLMDISTLR-----AATGD----FAESNKLGQGGFG 196 SP + N P T + + + D L + GD + K+GQG G Sbjct: 223 SPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTPFEKIGQGASG 282 Query: 197 AVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLL 373 VY + G+E+A+K+++ E + NE+ ++ + K+ N+V + L E + Sbjct: 283 TVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWV 342 Query: 374 VYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 V E++ SL ++ +T +D G + R + L++LH + Sbjct: 343 VMEYLAGGSLTDVVTET----CMDEGQIAAVCRECLQALEFLHSN 383
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 49.7 bits (117), Expect = 5e-06 Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 7/134 (5%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 +D+S LR G F +G G +G VYKG ++A ++ + EE+K E+ + Sbjct: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72 Query: 302 VAKLK-HKNLVRLVGVCLEQ------QERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRH 460 + K H+N+ G +++ + LV EF S+ ++ +T KG L Sbjct: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT-KGNALKEDCIA 131 Query: 461 RIIRGIARGLQYLH 502 I R I RGL +LH Sbjct: 132 YICREILRGLAHLH 145
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 49.7 bits (117), Expect = 5e-06 Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Frame = +2 Query: 146 ATGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAKLKH 319 ++ F + KLG G + VYKG G +A+K + S +G E++L+ +LKH Sbjct: 2 SSSQFKQLEKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 61 Query: 320 KNLVRLVGVCLEQQERLLVYEFVPN 394 N+VRL V + + LV+E++ N Sbjct: 62 DNIVRLYDVIHTENKLTLVFEYMDN 86
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 49.7 bits (117), Expect = 5e-06 Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 7/134 (5%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 +D+S LR G F +G G +G VYKG ++A ++ + EE+K E+ + Sbjct: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72 Query: 302 VAKLK-HKNLVRLVGVCLEQ------QERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRH 460 + K H+N+ G +++ + LV EF S+ ++ +T KG L Sbjct: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT-KGNALKEDCIA 131 Query: 461 RIIRGIARGLQYLH 502 I R I RGL +LH Sbjct: 132 YICREILRGLAHLH 145
>TAOK3_RAT (Q53UA7) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Axotomy-related gene 357 protein) Length = 898 Score = 49.7 bits (117), Expect = 5e-06 Identities = 34/119 (28%), Positives = 59/119 (49%), Gaps = 4/119 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVE---ELKNELALVAKLKHKN 325 F + +++G G FGAVY T E +A+K++S S Q E ++ E+ + +LKH N Sbjct: 24 FIDLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVRFLQQLKHPN 83 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 + G L++ LV E+ + D + + ++++ I G +GL YLH Sbjct: 84 TIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AITHGALQGLAYLH 139
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 49.7 bits (117), Expect = 5e-06 Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 6/118 (5%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 +LG G FG V+ GT ++A+K L K T E E ++ KLKH LV+L V + Sbjct: 275 RLGNGQFGEVWMGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKHDKLVQLYAV-V 332 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDW----GMRHRIIRGIA--RGLQYLHED 508 ++ +V E++ SL L D E G L M ++ RG+A + Y+H D Sbjct: 333 SEEPIYIVTEYMSKGSLLDFLKDGE-GRALKLPNLVDMAAQVARGMAYIERMNYIHRD 389
>UFO_MOUSE (Q00993) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (Adhesion-related kinase) Length = 888 Score = 49.7 bits (117), Expect = 5e-06 Identities = 35/122 (28%), Positives = 63/122 (51%), Gaps = 14/122 (11%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEI---AVK--RLSKSSTQGVEELKNELALVAKLKHKNLVRLV 340 LG+G FGAV +G L + I AVK +++ + +E+ +E + + H N++RL+ Sbjct: 536 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 595 Query: 341 GVCLEQQER------LLVYEFVPNRSLDQILFDTEKGEQ---LDWGMRHRIIRGIARGLQ 493 GVC + +R +++ F+ + L L + G+Q L M + + IA G++ Sbjct: 596 GVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGME 655 Query: 494 YL 499 YL Sbjct: 656 YL 657
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 49.7 bits (117), Expect = 5e-06 Identities = 32/129 (24%), Positives = 66/129 (51%), Gaps = 2/129 (1%) Frame = +2 Query: 137 LRAATGDFAESNKLGQGGFGAVYKG-TLPDGEEIAVKRLSKSSTQGVEELK-NELALVAK 310 + ++ F + KLG+G + VYKG G +A+K +S S +G E++L+ + Sbjct: 1 MTGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKE 60 Query: 311 LKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGL 490 L H+N+V L V + + LV+E++ ++ L + + + LD + + + +G+ Sbjct: 61 LDHENIVTLYDVIHTENKLTLVFEYM-DKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGI 119 Query: 491 QYLHEDSQL 517 + H++ L Sbjct: 120 MFCHDNRVL 128
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 49.7 bits (117), Expect = 5e-06 Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLV 340 +G G FG V G L P +EI A+K L T+ + E +++ + H N++RL Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + ++V E++ N SLD L + Q ++RGIA G++YL + Sbjct: 687 GVVTKSKPEMIVTEYMENGSLDSFL--RKHDAQFTVIQLVGMLRGIASGMKYLSD 739
>EGFR_HUMAN (P00533) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Receptor tyrosine-protein kinase ErbB-1) Length = 1210 Score = 49.7 bits (117), Expect = 5e-06 Identities = 40/130 (30%), Positives = 71/130 (54%), Gaps = 9/130 (6%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGT-LPDGEE----IAVKRLSK-SSTQGVEELKNELALVAKLK 316 +F + LG G FG VYKG +P+GE+ +A+K L + +S + +E+ +E ++A + Sbjct: 711 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 770 Query: 317 HKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK-GEQ--LDWGMRHRIIRGIARG 487 + ++ RL+G+CL +L+ LD + + G Q L+W ++ IA+G Sbjct: 771 NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ------IAKG 824 Query: 488 LQYLHEDSQL 517 + YL ED +L Sbjct: 825 MNYL-EDRRL 833
>TAOK3_XENLA (Q6DD27) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 896 Score = 49.7 bits (117), Expect = 5e-06 Identities = 36/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGTLPDGEEI-AVKRLSKSSTQGVE---ELKNELALVAKLKHKN 325 F + +++G G FGAVY T EI AVK++S S Q E ++ E+ + +LKH N Sbjct: 24 FVDLHEIGHGSFGAVYFATNSTTNEIVAVKKMSYSGKQMNEKWQDIIKEVKFLQQLKHPN 83 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 + G L+ LV E+ + D + + ++++ I G +GL YLH Sbjct: 84 TIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIA---AITHGALQGLAYLHS 140 Query: 506 DSQL 517 + + Sbjct: 141 HNMI 144
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 49.3 bits (116), Expect = 6e-06 Identities = 33/117 (28%), Positives = 58/117 (49%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +F KLG+G FG V++G +AVK + KS+ + +L E+ + L+H+ L+R Sbjct: 233 EFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVI-KSADMKLADLTKEIEALKSLRHERLIR 291 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 L +C + +V E + +L Q+ + +G+ L +A G+ YL E Sbjct: 292 LHAICSLGEPVYIVTELMGKGNL-QVYLGSSEGKALSLPHLLGFACQVAEGMSYLEE 347
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/115 (30%), Positives = 56/115 (48%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDG----EEIAVKRLSKSST-QGVEELKNELALVAKLKHKNLVRLV 340 +G G FG V +G L + +A+K L T Q + E +++ + H N++RL Sbjct: 615 IGAGEFGEVCRGKLKQAGRREQFVAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLE 674 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + +++ EF+ N +LD L Q I+RGIA G++YL E Sbjct: 675 GVVTRSRPVMILTEFMENGALDSFL--RMNDGQFTVIQLVGILRGIASGMKYLSE 727
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 49.3 bits (116), Expect = 6e-06 Identities = 37/115 (32%), Positives = 58/115 (50%), Gaps = 4/115 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 LG+G +G VY G L + IA+K + + ++ + L E+AL LKHKN+V+ +G Sbjct: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745 Query: 353 EQQERLLVYEFVPNRSLDQIL---FDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 E + E VP SL +L + K + G + I GL+YLH++ Sbjct: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGF---YTKQILEGLKYLHDN 797
>MOS_APTAU (P87347) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 49.3 bits (116), Expect = 6e-06 Identities = 41/129 (31%), Positives = 64/129 (49%), Gaps = 20/129 (15%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELA--LVAKLKHKNLVRLV--G 343 LG GGFG+VYK T G +AVK++ KSS + ++ A VA+L+H N+VR+V Sbjct: 8 LGSGGFGSVYKATY-HGATVAVKQVKKSSKNRLASRQSFWAELNVARLQHANVVRVVAAS 66 Query: 344 VCLEQQERLL---VYEFVPNRSLDQILFDT----EKGEQLDWGMRHRIIR---------G 475 C + L + E+V N +L +++ T +GE + G + + Sbjct: 67 TCAPASQNSLGTIIMEYVGNITLHHVIYGTSDAWRQGEDDEGGCGKKALSMEETVCYSCD 126 Query: 476 IARGLQYLH 502 I GL +LH Sbjct: 127 IMTGLAFLH 135
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 49.3 bits (116), Expect = 6e-06 Identities = 33/118 (27%), Positives = 67/118 (56%), Gaps = 3/118 (2%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGTLPD-GEEIAVKRLSKS-STQGVEELK-NELALVAKLKHKNL 328 F + K+G+G +G VYK + G+ +A+K++ +GV E++L+ +LKH N+ Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNI 63 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 VRL+ V +++ LV+EF+ ++ L + + D+ G +L + + + +G+ + H Sbjct: 64 VRLLDVVHNERKLYLVFEFL-SQDLKKYM-DSTPGSELPLHLIKSYLFQLLQGVSFCH 119
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/112 (31%), Positives = 52/112 (46%), Gaps = 3/112 (2%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 +G G GAV+ G GEE+AVK++ ++ L+ KLKH N++ GVC + Sbjct: 131 VGSGAQGAVFLGRF-HGEEVAVKKVRDLKETDIKHLR-------KLKHPNIITFKGVCTQ 182 Query: 356 QQERLLVYEFVPNRSLDQIL---FDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 ++ EF L ++L +DW M GIA G+ YLH Sbjct: 183 APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSM------GIAGGMNYLH 228
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 49.3 bits (116), Expect = 6e-06 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 558 DLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNI 617 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F +G +L +++ A G++YL Sbjct: 618 VRLIGVCTQKQPIYIVMELV--QGGDFLTFLRTEGARLRVKTLLQMMGDAAAGMEYL 672
>TAOK3_CHICK (Q9I9E0) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Kinase from chicken) Length = 898 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/124 (28%), Positives = 60/124 (48%), Gaps = 4/124 (3%) Frame = +2 Query: 158 FAESNKLGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVE---ELKNELALVAKLKHKN 325 F +++G G FGAVY T E +AVK++S S Q E ++ E+ + +LKH N Sbjct: 24 FVGLHEIGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTNEKWQDIIKEVKFLQQLKHPN 83 Query: 326 LVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 + G L++ LV E+ + D + + ++++ I G +GL YLH Sbjct: 84 TIEYKGCYLKEHTAWLVMEYCLGSASDMLEVHKKPLQEVEIA---AITHGALQGLAYLHS 140 Query: 506 DSQL 517 ++ Sbjct: 141 HCKI 144
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/112 (31%), Positives = 52/112 (46%), Gaps = 3/112 (2%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 +G G GAV+ G GEE+AVK++ ++ L+ KLKH N++ GVC + Sbjct: 164 VGSGAQGAVFLGRF-HGEEVAVKKVRDLKETDIKHLR-------KLKHPNIITFKGVCTQ 215 Query: 356 QQERLLVYEFVPNRSLDQIL---FDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 ++ EF L ++L +DW M GIA G+ YLH Sbjct: 216 APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSM------GIAGGMNYLH 261
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/112 (31%), Positives = 52/112 (46%), Gaps = 3/112 (2%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLE 355 +G G GAV+ G GEE+AVK++ ++ L+ KLKH N++ GVC + Sbjct: 164 VGSGAQGAVFLGRF-HGEEVAVKKVRDLKETDIKHLR-------KLKHPNIITFKGVCTQ 215 Query: 356 QQERLLVYEFVPNRSLDQIL---FDTEKGEQLDWGMRHRIIRGIARGLQYLH 502 ++ EF L ++L +DW M GIA G+ YLH Sbjct: 216 APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSM------GIAGGMNYLH 261
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 49.3 bits (116), Expect = 6e-06 Identities = 32/125 (25%), Positives = 63/125 (50%), Gaps = 16/125 (12%) Frame = +2 Query: 173 KLGQGGFGAVYKGTL----PDGEEI--AVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ P+ ++I AVK L +S ++ E L+ L+H+++V+ Sbjct: 539 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 598 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQ----------ILFDTEKGEQLDWGMRHRIIRGIAR 484 GVC+E ++V+E++ + L++ ++ + + +L I + IA Sbjct: 599 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAA 658 Query: 485 GLQYL 499 G+ YL Sbjct: 659 GMVYL 663
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 49.3 bits (116), Expect = 6e-06 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKGTL-PDGEEIAVKRLSKSSTQGVE-ELKNELALVAKLKHKNL 328 D ++G+G FG V+ G L D +AVK ++ ++ + E ++ + H N+ Sbjct: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNI 619 Query: 329 VRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 VRL+GVC ++Q +V E V + D + F +G +L +++ A G++YL Sbjct: 620 VRLIGVCTQKQPIYIVMELV--QGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 674
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 49.3 bits (116), Expect = 6e-06 Identities = 28/87 (32%), Positives = 50/87 (57%), Gaps = 6/87 (6%) Frame = +2 Query: 173 KLGQGGFGAVYKGT----LPDGEE--IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ L D ++ +AVK L ++S ++ E L+ L+H+++VR Sbjct: 518 ELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVR 577 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL 415 GVC E L+V+E++ + L++ L Sbjct: 578 FFGVCTEGGPLLMVFEYMRHGDLNRFL 604
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 49.3 bits (116), Expect = 6e-06 Identities = 27/74 (36%), Positives = 42/74 (56%), Gaps = 5/74 (6%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEE-----IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV 340 LG G FG VY+G L +E +A+K L K +++ EL E L++ KH+N+V L+ Sbjct: 2230 LGSGAFGEVYEGQLQAEDEAQPQRVAIKSLRKGASE-FAELLQEAQLMSNFKHENIVCLI 2288 Query: 341 GVCLEQQERLLVYE 382 G+C + L+ E Sbjct: 2289 GICCDTDSISLIME 2302
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 49.3 bits (116), Expect = 6e-06 Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 12/120 (10%) Frame = +2 Query: 176 LGQGGFGAVYKGTLPDGEE------IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRL 337 LG+ FG V+ EE + VK L Q + + EL + KL H N+VRL Sbjct: 802 LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRL 861 Query: 338 VGVCLEQQERLLVYEFVPNRSLDQILFDTE------KGEQLDWGMRHRIIRGIARGLQYL 499 +G+C E + +V E+V L Q L ++ K + L + + +A G+++L Sbjct: 862 LGLCREAEPHYMVLEYVDLEDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHL 921
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 49.3 bits (116), Expect = 6e-06 Identities = 37/109 (33%), Positives = 55/109 (50%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 KLGQG FG V+ GT D +A+K L K T E E ++ KL+H+ LV+L V + Sbjct: 271 KLGQGCFGEVWMGTWNDTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV-V 328 Query: 353 EQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 ++ +V E++ SL L E G+ L + IA G+ Y+ Sbjct: 329 SEEPIYIVIEYMSKGSLLDFL-KGEMGKYLRLPQLVDMAAQIASGMAYV 376
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 49.3 bits (116), Expect = 6e-06 Identities = 32/113 (28%), Positives = 59/113 (52%), Gaps = 2/113 (1%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVK--RLSKSSTQGVEELKNELALVAKLKHKNLVRLVGV 346 K+G+G +G VYK DGE A+K RL K E++++ +L+H N+V+L V Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDV 68 Query: 347 CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 ++ +LV+E + ++ L +++ + G L+ + + G+ Y HE Sbjct: 69 IHAKKRLILVFEHL-DQDLKKLIDVCDGG--LESVTAKSFLLQLLNGIAYCHE 118
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 49.3 bits (116), Expect = 6e-06 Identities = 32/113 (28%), Positives = 59/113 (52%), Gaps = 2/113 (1%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVK--RLSKSSTQGVEELKNELALVAKLKHKNLVRLVGV 346 K+G+G +G VYK DGE A+K RL K E++++ +L+H N+V+L V Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDV 68 Query: 347 CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 ++ +LV+E + ++ L +++ + G L+ + + G+ Y HE Sbjct: 69 IHAKKRLILVFEHL-DQDLKKLIDVCDGG--LESVTAKSFLLQLLNGIAYCHE 118
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 49.3 bits (116), Expect = 6e-06 Identities = 37/115 (32%), Positives = 58/115 (50%), Gaps = 4/115 (3%) Frame = +2 Query: 176 LGQGGFGAVYKGT-LPDGEEIAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCL 352 LG+G +G VY G L + IA+K + + ++ + L E+AL LKHKN+V+ +G Sbjct: 693 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 752 Query: 353 EQQERLLVYEFVPNRSLDQIL---FDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 E + E VP SL +L + K + G + I GL+YLH++ Sbjct: 753 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGF---YTKQILEGLKYLHDN 804
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 48.9 bits (115), Expect = 8e-06 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 13/153 (8%) Frame = +2 Query: 89 GKDTESVDSMLMDIS----TLRAATGDFAESNKLGQGGFGAVYK-GTLPDGEEIAVKRL- 250 G D ++ +MDIS + RA T ++ LGQG FG VY + G E+AVK++ Sbjct: 330 GSDIDNPTLTVMDISPPSRSPRAPT-NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQ 388 Query: 251 ----SKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLL--VYEFVPNRSL-DQ 409 S +++ V L+ E+ L+ L H+ +V+ G + QE+ L E++P S+ DQ Sbjct: 389 FDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQ 448 Query: 410 ILFDTEKGEQLDWGMRHRIIRGIARGLQYLHED 508 + + L + + R I G+ YLH + Sbjct: 449 L----KAYGALTENVTRKYTRQILEGVHYLHSN 477
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 48.9 bits (115), Expect = 8e-06 Identities = 26/87 (29%), Positives = 50/87 (57%), Gaps = 6/87 (6%) Frame = +2 Query: 173 KLGQGGFGAVYKGTL----PDGEEI--AVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ P+ ++I AVK L +S ++ E L+ L+H+++V+ Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL 415 GVC+E ++V+E++ + L++ L Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 48.9 bits (115), Expect = 8e-06 Identities = 26/87 (29%), Positives = 50/87 (57%), Gaps = 6/87 (6%) Frame = +2 Query: 173 KLGQGGFGAVYKGTL----PDGEEI--AVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ P+ ++I AVK L +S ++ E L+ L+H+++V+ Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL 415 GVC+E ++V+E++ + L++ L Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 48.9 bits (115), Expect = 8e-06 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 18/127 (14%) Frame = +2 Query: 173 KLGQGGFGAVYKGT----LPDGEE--IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ LP+ E+ +AVK L + + + + E L+ L+H+++V+ Sbjct: 498 ELGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVK 557 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL---------FDTEKGE---QLDWGMRHRIIRGI 478 GVC E ++V+E++ + L++ L D +G+ QL +I I Sbjct: 558 FYGVCTEGDPLIMVFEYMKHGDLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQI 617 Query: 479 ARGLQYL 499 A G+ YL Sbjct: 618 ASGMVYL 624
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 48.9 bits (115), Expect = 8e-06 Identities = 34/121 (28%), Positives = 64/121 (52%), Gaps = 5/121 (4%) Frame = +2 Query: 155 DFAESNKLGQGGFGAVYKG--TLPDGEEIAVKRLS-KSSTQGVEELK-NELALVAKLKHK 322 D+ K+G+G +G VYK T + +A+K++ +S +GV E++L+ ++K Sbjct: 6 DYQRQEKVGEGTYGVVYKALDTKHNNRVVALKKIRLESEDEGVPSTAIREISLLKEMKDD 65 Query: 323 NLVRLVGVCLEQQERL-LVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYL 499 N+VRL + +L LV+EF+ + L + + +G L M R + + RG+++ Sbjct: 66 NIVRLYDIIHSDSHKLYLVFEFL-DLDLKKYMESIPQGVGLGANMIKRFMNQLIRGIKHC 124 Query: 500 H 502 H Sbjct: 125 H 125
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 48.9 bits (115), Expect = 8e-06 Identities = 39/134 (29%), Positives = 64/134 (47%), Gaps = 7/134 (5%) Frame = +2 Query: 122 MDISTLRAATGDFAESNKLGQGGFGAVYKGTLPDGEEIAVKRLSKSSTQGVEELKNELAL 301 +D+S+LR G F +G G +G VYKG ++A ++ + EE+K E+ + Sbjct: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72 Query: 302 VAKLK-HKNLVRLVGVCLEQ------QERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRH 460 + K H+N+ G +++ + LV EF S+ ++ +T KG L Sbjct: 73 LKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT-KGNTLKEDWIA 131 Query: 461 RIIRGIARGLQYLH 502 I R I RGL +LH Sbjct: 132 YISREILRGLAHLH 145
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 48.9 bits (115), Expect = 8e-06 Identities = 26/87 (29%), Positives = 50/87 (57%), Gaps = 6/87 (6%) Frame = +2 Query: 173 KLGQGGFGAVYKGTL----PDGEEI--AVKRLSKSSTQGVEELKNELALVAKLKHKNLVR 334 +LG+G FG V+ P+ ++I AVK L +S ++ E L+ L+H+++V+ Sbjct: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 602 Query: 335 LVGVCLEQQERLLVYEFVPNRSLDQIL 415 GVC+E ++V+E++ + L++ L Sbjct: 603 FYGVCVEGDPLIMVFEYMKHGDLNKFL 629
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 48.9 bits (115), Expect = 8e-06 Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 5/115 (4%) Frame = +2 Query: 176 LGQGGFGAVYKGTL--PDGEEI--AVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLV 340 +G G FG V G L P +EI A+K L T+ + E +++ + H N++RL Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 341 GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 GV + + ++V E++ N SLD L + Q ++RGIA G++YL + Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFL--RKHDAQFTVIQLVGMLRGIASGMKYLSD 739
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 48.9 bits (115), Expect = 8e-06 Identities = 30/114 (26%), Positives = 63/114 (55%), Gaps = 3/114 (2%) Frame = +2 Query: 173 KLGQGGFGAVYKGTLPDGEEIAVKRLS-KSSTQGVEELKN--ELALVAKLKHKNLVRLVG 343 K+G+G +G VYK DGE A+K++ + +G+ + E++++ +L+H N+V+L Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTVSIREISILKELRHSNIVKLYD 68 Query: 344 VCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWGMRHRIIRGIARGLQYLHE 505 V ++ +LV+E + ++ L +++ + G L+ + + G+ Y HE Sbjct: 69 VIHAKKRLILVFEHL-DQDLKKLIDVCDGG--LESVTAKSFLLQLLNGIAYCHE 119 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 69,263,522 Number of Sequences: 219361 Number of extensions: 1432202 Number of successful extensions: 8658 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7320 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8136 length of database: 80,573,946 effective HSP length: 104 effective length of database: 57,760,402 effective search space used: 3927707336 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
