ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags21j23 |
|---|---|
| Clone Library Name | barley_pub |
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 197 bits (501), Expect = 5e-51 Identities = 88/129 (68%), Positives = 108/129 (83%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 +V MCH GVMHRDLKPENFL +K + ++KAIDFGLSVFF PG+ FTE+VGSPYY+AP Sbjct: 190 IVAMCHSLGVMHRDLKPENFLLLDKDDDLSIKAIDFGLSVFFKPGQVFTELVGSPYYVAP 249 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL + YG E DVWSAGVILY+LL GVPPFWAET+QG+ A+++ IDF+ DPWP++SD+ Sbjct: 250 EVLHKRYGPESDVWSAGVILYVLLSGVPPFWAETQQGIFDAVLKGHIDFQSDPWPKISDS 309 Query: 374 AKDLVRGML 400 AKDL+R ML Sbjct: 310 AKDLIRKML 318
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 192 bits (487), Expect = 2e-49 Identities = 86/129 (66%), Positives = 105/129 (81%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 VV+ CH GVMHRDLKPENFLF +K E + LK IDFGLS+FF P + FT++VGSPYY+AP Sbjct: 261 VVEACHSLGVMHRDLKPENFLFVSKHEDSLLKTIDFGLSMFFKPDDVFTDVVGSPYYVAP 320 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL++ YG E DVWSAGVI+YILL GVPPFWAETEQG+ + ++ +DF DPWP +S++ Sbjct: 321 EVLRKRYGPEADVWSAGVIVYILLSGVPPFWAETEQGIFEQVLHGDLDFSSDPWPSISES 380 Query: 374 AKDLVRGML 400 AKDLVR ML Sbjct: 381 AKDLVRKML 389
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 191 bits (484), Expect = 5e-49 Identities = 89/129 (68%), Positives = 106/129 (82%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 VV +CH GVMHRDLKPENFL A K+E A LKA DFGLSVF G+ + +IVGS YY+AP Sbjct: 196 VVNICHFMGVMHRDLKPENFLLATKEENAMLKATDFGLSVFIEEGKMYRDIVGSAYYVAP 255 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL+RNYG+E+DVWSAGVILYILL GVPPFWAETE+G+ AI++ IDF+ PWP +S++ Sbjct: 256 EVLRRNYGKEIDVWSAGVILYILLSGVPPFWAETEKGIFDAILQGEIDFESQPWPSISES 315 Query: 374 AKDLVRGML 400 AKDLVR ML Sbjct: 316 AKDLVRKML 324
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 187 bits (474), Expect = 7e-48 Identities = 87/130 (66%), Positives = 103/130 (79%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 EVV+ CH GVMHRDLKPENFLF E A LKA DFGLSVF+ PGE F ++VGSPYY+A Sbjct: 144 EVVEACHSLGVMHRDLKPENFLFDTIDEDAKLKATDFGLSVFYKPGESFCDVVGSPYYVA 203 Query: 191 PEVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 PEVL++ YG E DVWSAGVILYILL GVPPFWAE+E G+ + I+ +DF +PWP +SD Sbjct: 204 PEVLRKLYGPESDVWSAGVILYILLSGVPPFWAESEPGIFRQILLGKLDFHSEPWPSISD 263 Query: 371 NAKDLVRGML 400 +AKDL+R ML Sbjct: 264 SAKDLIRKML 273
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 185 bits (470), Expect = 2e-47 Identities = 79/129 (61%), Positives = 105/129 (81%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 +++ CH HGVMHRDLKPENFL + + ++KAIDFGLSVFF PG+ F E+VGSPYY+AP Sbjct: 184 IIETCHSHGVMHRDLKPENFLLLDADDEFSVKAIDFGLSVFFRPGQVFREVVGSPYYIAP 243 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL++ YG E D+W+AGVILY+LL GVPPFWA+T+ G+ + ++ IDFK + WPR+SD+ Sbjct: 244 EVLEKRYGPEADIWTAGVILYVLLTGVPPFWADTQSGIYEKVLDGRIDFKSNRWPRISDS 303 Query: 374 AKDLVRGML 400 AKDL++ ML Sbjct: 304 AKDLIKKML 312
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 184 bits (467), Expect = 4e-47 Identities = 86/129 (66%), Positives = 105/129 (81%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 VV +CH GVMHRDLKPENFL ++K + A LKA DFGLSVF G+ + IVGS YY+AP Sbjct: 192 VVHVCHFMGVMHRDLKPENFLLSSKDKDAMLKATDFGLSVFIEEGKVYRNIVGSAYYVAP 251 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL+R+YG+E+D+WSAGVILYILL GVPPFWAE E+G+ AI+ VIDF+ +PWP VS++ Sbjct: 252 EVLRRSYGKEIDIWSAGVILYILLSGVPPFWAENEKGIFDAILEGVIDFESEPWPSVSNS 311 Query: 374 AKDLVRGML 400 AKDLVR ML Sbjct: 312 AKDLVRKML 320
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 184 bits (466), Expect = 6e-47 Identities = 86/129 (66%), Positives = 103/129 (79%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 VV +CH GVMHRDLKPENFL A +E A LKA DFGLSVF G+ + +IVGS YY+AP Sbjct: 176 VVNICHFMGVMHRDLKPENFLLATMEENAMLKATDFGLSVFIEEGKMYRDIVGSAYYVAP 235 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL+R+YG+E+DVWSAGVILYILL GVPPFWAE E+G+ AI+ IDF+ PWP +S++ Sbjct: 236 EVLRRSYGKEIDVWSAGVILYILLSGVPPFWAEIEKGIFDAILHEEIDFESQPWPSISES 295 Query: 374 AKDLVRGML 400 AKDLVR ML Sbjct: 296 AKDLVRKML 304
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 165 bits (418), Expect = 2e-41 Identities = 77/129 (59%), Positives = 93/129 (72%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 VV CH GV+HRDLKPENFLF +K E + LKAIDFGLS + P ER +IVGS YY+AP Sbjct: 263 VVAFCHLQGVVHRDLKPENFLFKSKDEDSQLKAIDFGLSDYVKPDERLNDIVGSAYYVAP 322 Query: 194 EVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 EVL R+Y E DVWS GVI YILLCG PFWA TE G+ +A++++ + F PWP VS Sbjct: 323 EVLHRSYSTEADVWSIGVISYILLCGSRPFWARTESGIFRAVLKANLSFDEPPWPSVSSE 382 Query: 374 AKDLVRGML 400 AKD V+ +L Sbjct: 383 AKDFVKRLL 391
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 132 bits (331), Expect = 3e-31 Identities = 57/124 (45%), Positives = 83/124 (66%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HKH ++HRD+KPEN L NK +K +DFGLS FF+ + + +G+ YY+APEVLK+ Sbjct: 181 HKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLKK 240 Query: 209 NYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLV 388 Y ++ DVWS GVI+YILLCG PPF + +Q + + + + F + W +SD AK+L+ Sbjct: 241 KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELI 300 Query: 389 RGML 400 + ML Sbjct: 301 KLML 304
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 130 bits (327), Expect = 7e-31 Identities = 56/124 (45%), Positives = 83/124 (66%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HKH ++HRD+KPEN L NK +K +DFGLS FF+ + + +G+ YY+APEVL++ Sbjct: 182 HKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRK 241 Query: 209 NYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLV 388 Y ++ DVWS GVILYILLCG PPF + +Q + + + + F + W +S+ AK+L+ Sbjct: 242 KYNEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELI 301 Query: 389 RGML 400 + ML Sbjct: 302 KLML 305
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 130 bits (327), Expect = 7e-31 Identities = 56/124 (45%), Positives = 83/124 (66%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HKH ++HRD+KPEN L NK +K +DFGLS FF+ + + +G+ YY+APEVL++ Sbjct: 182 HKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRK 241 Query: 209 NYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLV 388 Y ++ DVWS GVILYILLCG PPF + +Q + + + + F + W +S+ AK+L+ Sbjct: 242 KYNEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELI 301 Query: 389 RGML 400 + ML Sbjct: 302 KLML 305
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 122 bits (306), Expect = 2e-28 Identities = 63/132 (47%), Positives = 85/132 (64%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFT-PGERFTEIVGSPYYM 187 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ +R+ G+P Y+ Sbjct: 121 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQRWFGFAGTPGYL 180 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W V Sbjct: 181 SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKARAYDFPSPEWDTV 240 Query: 365 SDNAKDLVRGML 400 + AKDL+ ML Sbjct: 241 TPEAKDLINKML 252
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 121 bits (304), Expect = 3e-28 Identities = 61/132 (46%), Positives = 85/132 (64%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER-FTEIVGSPYYM 187 E V CH +G++HRDLKPEN L A+K + AA+K DFGL++ ++ + G+P Y+ Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W V Sbjct: 182 SPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV 241 Query: 365 SDNAKDLVRGML 400 + AKDL+ ML Sbjct: 242 TPEAKDLINKML 253
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 121 bits (304), Expect = 3e-28 Identities = 61/132 (46%), Positives = 85/132 (64%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER-FTEIVGSPYYM 187 E V CH +G++HRDLKPEN L A+K + AA+K DFGL++ ++ + G+P Y+ Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W V Sbjct: 182 SPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV 241 Query: 365 SDNAKDLVRGML 400 + AKDL+ ML Sbjct: 242 TPEAKDLINKML 253
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 121 bits (303), Expect = 5e-28 Identities = 64/133 (48%), Positives = 86/133 (64%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ GE+ + G+P Y Sbjct: 121 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE-VEGEQQAWFGFAGTPGY 179 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W Sbjct: 180 LSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT 239 Query: 362 VSDNAKDLVRGML 400 V+ AKDL+ ML Sbjct: 240 VTPEAKDLINKML 252
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 121 bits (303), Expect = 5e-28 Identities = 64/133 (48%), Positives = 86/133 (64%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ GE+ + G+P Y Sbjct: 121 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE-VEGEQQAWFGFAGTPGY 179 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W Sbjct: 180 LSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT 239 Query: 362 VSDNAKDLVRGML 400 V+ AKDL+ ML Sbjct: 240 VTPEAKDLINKML 252
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 121 bits (303), Expect = 5e-28 Identities = 64/133 (48%), Positives = 86/133 (64%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ GE+ + G+P Y Sbjct: 121 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE-VEGEQQAWFGFAGTPGY 179 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W Sbjct: 180 LSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT 239 Query: 362 VSDNAKDLVRGML 400 V+ AKDL+ ML Sbjct: 240 VTPEAKDLINKML 252
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 120 bits (301), Expect = 8e-28 Identities = 55/124 (44%), Positives = 81/124 (65%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 H ++HRDLKPENFLF ++ + + LK IDFGLS GE T G+PYY+AP+VL Sbjct: 183 HSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG 242 Query: 209 NYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLV 388 Y ++ D+WS+GVI+Y LLCG PPF+ +T+ V + + + F + W +S +AK+L+ Sbjct: 243 KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLI 302 Query: 389 RGML 400 +L Sbjct: 303 TKLL 306
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 120 bits (301), Expect = 8e-28 Identities = 55/124 (44%), Positives = 81/124 (65%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 H ++HRDLKPENFLF ++ + + LK IDFGLS GE T G+PYY+AP+VL Sbjct: 183 HSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG 242 Query: 209 NYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLV 388 Y ++ D+WS+GVI+Y LLCG PPF+ +T+ V + + + F + W +S +AK+L+ Sbjct: 243 KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLI 302 Query: 389 RGML 400 +L Sbjct: 303 TKLL 306
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 119 bits (298), Expect = 2e-27 Identities = 61/132 (46%), Positives = 84/132 (63%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER-FTEIVGSPYYM 187 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ ++ + G+P Y+ Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVL++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W V Sbjct: 182 SPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 241 Query: 365 SDNAKDLVRGML 400 + AK+L+ ML Sbjct: 242 TPEAKNLINQML 253
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 119 bits (298), Expect = 2e-27 Identities = 61/132 (46%), Positives = 84/132 (63%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER-FTEIVGSPYYM 187 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ ++ + G+P Y+ Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVL++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W V Sbjct: 182 SPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 241 Query: 365 SDNAKDLVRGML 400 + AK+L+ ML Sbjct: 242 TPEAKNLINQML 253
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 119 bits (298), Expect = 2e-27 Identities = 61/132 (46%), Positives = 84/132 (63%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER-FTEIVGSPYYM 187 E V CH+ GV+HRDLKPEN L A+K + AA+K DFGL++ ++ + G+P Y+ Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVL++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W V Sbjct: 182 SPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 241 Query: 365 SDNAKDLVRGML 400 + AK+L+ ML Sbjct: 242 TPEAKNLINQML 253
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 119 bits (297), Expect = 2e-27 Identities = 60/132 (45%), Positives = 83/132 (62%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER-FTEIVGSPYYM 187 E V CH++GV+HRDLKPEN L A+K + AA+K DFGL++ + + G+P Y+ Sbjct: 122 ESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYL 181 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PEVLK+ YG+ VD+W+ GVILYILL G PPFW E + + I D+ W V Sbjct: 182 SPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTV 241 Query: 365 SDNAKDLVRGML 400 + AK+L+ ML Sbjct: 242 TPEAKNLINQML 253
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 118 bits (295), Expect = 4e-27 Identities = 54/130 (41%), Positives = 80/130 (61%), Gaps = 1/130 (0%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE-RFTEIVGSPYYMA 190 V+ H + HRD+KPENFLF +K + +K IDFGL+ +F + G+PYY+A Sbjct: 219 VLNYLHIRNICHRDIKPENFLFYDKSTESLIKIIDFGLAAYFNDIDYEMKTKAGTPYYVA 278 Query: 191 PEVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 P+VL Y + D+WSAGV+ YI+LCG PPF+ E++ + + + +FK W +SD Sbjct: 279 PQVLTGCYDYKCDLWSAGVLFYIILCGYPPFYGESDHEILSMVKKGKYNFKGKEWNNISD 338 Query: 371 NAKDLVRGML 400 AKDL++ L Sbjct: 339 EAKDLIKRCL 348
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 116 bits (291), Expect = 1e-26 Identities = 61/133 (45%), Positives = 85/133 (63%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 E V H+H ++HRDLKPEN L A+K + AA+K DFGL++ GE+ + G+P Y Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIE-VQGEQQAWFGFAGTPGY 180 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W Sbjct: 181 LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT 240 Query: 362 VSDNAKDLVRGML 400 V+ AK+L+ ML Sbjct: 241 VTPEAKNLINQML 253
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 116 bits (291), Expect = 1e-26 Identities = 61/133 (45%), Positives = 85/133 (63%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 E V H+H ++HRDLKPEN L A+K + AA+K DFGL++ GE+ + G+P Y Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIE-VQGEQQAWFGFAGTPGY 180 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W Sbjct: 181 LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT 240 Query: 362 VSDNAKDLVRGML 400 V+ AK+L+ ML Sbjct: 241 VTPEAKNLINQML 253
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 116 bits (291), Expect = 1e-26 Identities = 61/133 (45%), Positives = 85/133 (63%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 E V H+H ++HRDLKPEN L A+K + AA+K DFGL++ GE+ + G+P Y Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIE-VQGEQQAWFGFAGTPGY 180 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PEVL+++ YG+ VD+W+ GVILYILL G PPFW E + + Q I DF W Sbjct: 181 LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT 240 Query: 362 VSDNAKDLVRGML 400 V+ AK+L+ ML Sbjct: 241 VTPEAKNLINQML 253
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 116 bits (290), Expect = 1e-26 Identities = 53/130 (40%), Positives = 79/130 (60%), Gaps = 1/130 (0%) Frame = +2 Query: 14 VVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE-RFTEIVGSPYYMA 190 V+ H + HRD+KPENFLF + + +K IDFGL+ +FT G+PYY+A Sbjct: 225 VLNYLHIRNICHRDIKPENFLFYDMTPESLIKIIDFGLASYFTHNNYEMKTKAGTPYYVA 284 Query: 191 PEVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 P+VL +Y + D+WS+GV+ YILLCG PPF+ E++ + + + FK W +S+ Sbjct: 285 PQVLTGSYNYKCDMWSSGVLFYILLCGYPPFFGESDHEILSMVKKGKYQFKGKEWNNISE 344 Query: 371 NAKDLVRGML 400 AKDL++ L Sbjct: 345 EAKDLIKRCL 354
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 114 bits (286), Expect = 4e-26 Identities = 54/131 (41%), Positives = 83/131 (63%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + V H+ G++HRDLKPEN L+ ++ E + + DFGLS G+ + G+P Y+A Sbjct: 130 DAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVA 189 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL ++ Y + VD WS GVI YILLCG PPF+ E + + + I+++ +F W +S Sbjct: 190 PEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDIS 249 Query: 368 DNAKDLVRGML 400 D+AKD +R ++ Sbjct: 250 DSAKDFIRNLM 260
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 114 bits (286), Expect = 4e-26 Identities = 54/131 (41%), Positives = 83/131 (63%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + V H+ G++HRDLKPEN L+ ++ E + + DFGLS G+ + G+P Y+A Sbjct: 130 DAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVA 189 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL ++ Y + VD WS GVI YILLCG PPF+ E + + + I+++ +F W +S Sbjct: 190 PEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDIS 249 Query: 368 DNAKDLVRGML 400 D+AKD +R ++ Sbjct: 250 DSAKDFIRNLM 260
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 114 bits (285), Expect = 6e-26 Identities = 55/131 (41%), Positives = 82/131 (62%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + V+ H G++HRDLKPEN L+ + E + + DFGLS PG + G+P Y+A Sbjct: 127 DAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVA 186 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL ++ Y + VD WS GVI YILLCG PPF+ E + + + I+++ +F W +S Sbjct: 187 PEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDIS 246 Query: 368 DNAKDLVRGML 400 D+AKD +R ++ Sbjct: 247 DSAKDFIRHLM 257
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 114 bits (285), Expect = 6e-26 Identities = 55/131 (41%), Positives = 82/131 (62%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + V+ H G++HRDLKPEN L+ + E + + DFGLS PG + G+P Y+A Sbjct: 127 DAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVA 186 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL ++ Y + VD WS GVI YILLCG PPF+ E + + + I+++ +F W +S Sbjct: 187 PEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDIS 246 Query: 368 DNAKDLVRGML 400 D+AKD +R ++ Sbjct: 247 DSAKDFIRHLM 257
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 114 bits (285), Expect = 6e-26 Identities = 55/131 (41%), Positives = 82/131 (62%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + V+ H G++HRDLKPEN L+ + E + + DFGLS PG + G+P Y+A Sbjct: 127 DAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVA 186 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL ++ Y + VD WS GVI YILLCG PPF+ E + + + I+++ +F W +S Sbjct: 187 PEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDIS 246 Query: 368 DNAKDLVRGML 400 D+AKD +R ++ Sbjct: 247 DSAKDFIRHLM 257
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 114 bits (284), Expect = 7e-26 Identities = 56/125 (44%), Positives = 77/125 (61%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANK-KETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 HK+ V+HRDLKPEN L K KE +K IDFGLS F ++ + +G+ YY+AP+VL Sbjct: 184 HKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLH 243 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 Y ++ D+WS GVILYILL G PPF E + + + F + ++SD AKDL Sbjct: 244 GTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKAKDL 303 Query: 386 VRGML 400 ++ ML Sbjct: 304 IKKML 308
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 114 bits (284), Expect = 7e-26 Identities = 56/125 (44%), Positives = 77/125 (61%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANK-KETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 HK+ V+HRDLKPEN L K KE +K IDFGLS F ++ + +G+ YY+AP+VL Sbjct: 184 HKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLH 243 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 Y ++ D+WS GVILYILL G PPF E + + + F + ++SD AKDL Sbjct: 244 GTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDL 303 Query: 386 VRGML 400 ++ ML Sbjct: 304 IKKML 308
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 114 bits (284), Expect = 7e-26 Identities = 56/125 (44%), Positives = 77/125 (61%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANK-KETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 HK+ V+HRDLKPEN L K KE +K IDFGLS F ++ + +G+ YY+AP+VL Sbjct: 184 HKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLH 243 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 Y ++ D+WS GVILYILL G PPF E + + + F + ++SD AKDL Sbjct: 244 GTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVETGKYTFDLPQFKKISDKAKDL 303 Query: 386 VRGML 400 ++ ML Sbjct: 304 IKKML 308
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 110 bits (274), Expect = 1e-24 Identities = 56/129 (43%), Positives = 80/129 (62%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V H G++HRDLKPEN L+A E + + DFGLS G G+P Y+APE Sbjct: 124 VSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPE 182 Query: 197 VLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 +L++ YG+ VDVW+ GVI YILLCG PPF+ E++ + I+R+ +F W +S++ Sbjct: 183 LLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISES 242 Query: 374 AKDLVRGML 400 AKD +R +L Sbjct: 243 AKDFIRHLL 251
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 110 bits (274), Expect = 1e-24 Identities = 56/129 (43%), Positives = 80/129 (62%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V H G++HRDLKPEN L+A E + + DFGLS G G+P Y+APE Sbjct: 124 VSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPE 182 Query: 197 VLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 +L++ YG+ VDVW+ GVI YILLCG PPF+ E++ + I+R+ +F W +S++ Sbjct: 183 LLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISES 242 Query: 374 AKDLVRGML 400 AKD +R +L Sbjct: 243 AKDFIRHLL 251
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 110 bits (274), Expect = 1e-24 Identities = 56/129 (43%), Positives = 80/129 (62%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V H G++HRDLKPEN L+A E + + DFGLS G G+P Y+APE Sbjct: 124 VSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPE 182 Query: 197 VLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 +L++ YG+ VDVW+ GVI YILLCG PPF+ E++ + I+R+ +F W +S++ Sbjct: 183 LLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISES 242 Query: 374 AKDLVRGML 400 AKD +R +L Sbjct: 243 AKDFIRHLL 251
>MAPK3_HUMAN (Q16644) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK) Length = 382 Score = 109 bits (272), Expect = 2e-24 Identities = 56/133 (42%), Positives = 79/133 (59%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 +Q H H + HRD+KPEN L+ +K++ A LK DFG + T T +PYY+APE Sbjct: 154 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCY-TPYYVAPE 212 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV----IDFKRDPWPR 361 VL Y + D+WS GVI+YILLCG PPF++ T Q ++ + R + F W Sbjct: 213 VLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSE 272 Query: 362 VSDNAKDLVRGML 400 VS++AK L+R +L Sbjct: 273 VSEDAKQLIRLLL 285
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 109 bits (272), Expect = 2e-24 Identities = 57/137 (41%), Positives = 76/137 (55%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 EV+ HK ++HRDLKPEN L + +K DFG S PGER E+ G+P Y+A Sbjct: 135 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLREVCGTPSYLA 191 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+++ + YG+EVD+WS GVI+Y LL G PPFW + + + I+ F Sbjct: 192 PEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSP 251 Query: 350 PWPRVSDNAKDLVRGML 400 W SD KDLV L Sbjct: 252 EWDDYSDTVKDLVSRFL 268
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 108 bits (270), Expect = 3e-24 Identities = 56/129 (43%), Positives = 80/129 (62%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ H++G++HRDLKPEN L+ +E + + DFGLS G T G+P Y+APE Sbjct: 131 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGVMST-ACGTPGYVAPE 189 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 VL ++ Y + VD WS GVI YILLCG PPF+ ETE + + I +F+ W +S++ Sbjct: 190 VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISES 249 Query: 374 AKDLVRGML 400 AKD + +L Sbjct: 250 AKDFICHLL 258
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 108 bits (270), Expect = 3e-24 Identities = 57/137 (41%), Positives = 76/137 (55%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 EVV HK ++HRDLKPEN L + +K DFG S PGE+ E+ G+P Y+A Sbjct: 135 EVVCTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLQPGEKLREVCGTPSYLA 191 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+++ + YG+EVD+WS GVI+Y LL G PPFW + + + I+ F Sbjct: 192 PEIIQCSMDEGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSP 251 Query: 350 PWPRVSDNAKDLVRGML 400 W SD KDLV L Sbjct: 252 EWDDYSDTVKDLVSRFL 268
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 108 bits (270), Expect = 3e-24 Identities = 56/129 (43%), Positives = 80/129 (62%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ H++G++HRDLKPEN L+ +E + + DFGLS G T G+P Y+APE Sbjct: 131 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGVMST-ACGTPGYVAPE 189 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 VL ++ Y + VD WS GVI YILLCG PPF+ ETE + + I +F+ W +S++ Sbjct: 190 VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISES 249 Query: 374 AKDLVRGML 400 AKD + +L Sbjct: 250 AKDFICHLL 258
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 108 bits (270), Expect = 3e-24 Identities = 60/132 (45%), Positives = 78/132 (59%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H++G++HRDLKPEN L+A A LK DFGLS + G+P Y A Sbjct: 150 EAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 209 Query: 191 PEVLKR-NYGQEVDVWSAGVILYILLCGVPPFWAET-EQGVAQAIIRSVIDFKRDPWPRV 364 PE+L+ YG EVD+WS G+I YILLCG PF+ E +Q + + I+ F W V Sbjct: 210 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEV 269 Query: 365 SDNAKDLVRGML 400 S NAKDLVR ++ Sbjct: 270 SLNAKDLVRKLI 281
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 108 bits (269), Expect = 4e-24 Identities = 56/129 (43%), Positives = 80/129 (62%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ H++G++HRDLKPEN L+ +E + + DFGLS G T G+P Y+APE Sbjct: 131 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST-ACGTPGYVAPE 189 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 VL ++ Y + VD WS GVI YILLCG PPF+ ETE + + I +F+ W +S++ Sbjct: 190 VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISES 249 Query: 374 AKDLVRGML 400 AKD + +L Sbjct: 250 AKDFICHLL 258
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 108 bits (269), Expect = 4e-24 Identities = 56/137 (40%), Positives = 76/137 (55%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 EV+ HK ++HRDLKPEN L + +K DFG S PGE+ E+ G+P Y+A Sbjct: 135 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLQPGEKLREVCGTPSYLA 191 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+++ + YG+EVD+WS GVI+Y LL G PPFW + + + I+ F Sbjct: 192 PEIIQCSMDDGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSP 251 Query: 350 PWPRVSDNAKDLVRGML 400 W SD KDLV L Sbjct: 252 EWDDYSDTVKDLVSRFL 268
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 107 bits (268), Expect = 5e-24 Identities = 56/137 (40%), Positives = 76/137 (55%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 EV+ HK ++HRDLKPEN L + +K DFG S PGE+ E+ G+P Y+A Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMN---IKLTDFGFSCQLDPGEKLREVCGTPSYLA 191 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+++ + YG+EVD+WS GVI+Y LL G PPFW + + + I+ F Sbjct: 192 PEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSP 251 Query: 350 PWPRVSDNAKDLVRGML 400 W SD KDLV L Sbjct: 252 EWDDYSDTVKDLVSRFL 268
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 107 bits (267), Expect = 7e-24 Identities = 59/132 (44%), Positives = 78/132 (59%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H++G++HRDLKPEN L+A A LK DFGLS + G+P Y A Sbjct: 146 EAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 205 Query: 191 PEVLKR-NYGQEVDVWSAGVILYILLCGVPPFWAET-EQGVAQAIIRSVIDFKRDPWPRV 364 PE+L+ YG EVD+WS G+I YILLCG PF+ E +Q + + I+ F W V Sbjct: 206 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEV 265 Query: 365 SDNAKDLVRGML 400 S NAKDLV+ ++ Sbjct: 266 SLNAKDLVKKLI 277
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 107 bits (267), Expect = 7e-24 Identities = 59/132 (44%), Positives = 78/132 (59%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H++G++HRDLKPEN L+A A LK DFGLS + G+P Y A Sbjct: 146 EAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 205 Query: 191 PEVLKR-NYGQEVDVWSAGVILYILLCGVPPFWAET-EQGVAQAIIRSVIDFKRDPWPRV 364 PE+L+ YG EVD+WS G+I YILLCG PF+ E +Q + + I+ F W V Sbjct: 206 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEV 265 Query: 365 SDNAKDLVRGML 400 S NAKDLV+ ++ Sbjct: 266 SLNAKDLVKKLI 277
>MAPK3_RAT (Q66H84) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 106 bits (264), Expect = 2e-23 Identities = 55/133 (41%), Positives = 79/133 (59%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 +Q H + HRD+KPEN L+ +K++ A LK DFG + T T +PYY+APE Sbjct: 156 IQFLHSQNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCY-TPYYVAPE 214 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV----IDFKRDPWPR 361 VL Y + D+WS GVI+YILLCG PPF++ T Q ++ + R + F + W Sbjct: 215 VLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPKPEWAD 274 Query: 362 VSDNAKDLVRGML 400 VS++AK L+R +L Sbjct: 275 VSEDAKQLIRLLL 287
>MAPK3_MOUSE (Q3UMW7) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 105 bits (261), Expect = 3e-23 Identities = 55/133 (41%), Positives = 78/133 (58%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 +Q H + HRD+KPEN L+ +K++ A LK DFG + T T +PYY+APE Sbjct: 156 IQFLHSRNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCY-TPYYVAPE 214 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV----IDFKRDPWPR 361 VL Y + D+WS GVI+YILLCG PPF++ T Q ++ + R + F W Sbjct: 215 VLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYSFPNPEWLD 274 Query: 362 VSDNAKDLVRGML 400 VS++AK L+R +L Sbjct: 275 VSEDAKQLIRLLL 287
>MAPK3_BOVIN (Q3SYZ2) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 105 bits (261), Expect = 3e-23 Identities = 55/133 (41%), Positives = 77/133 (57%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 +Q H + HRD+KPEN L+ +K + A LK DFG + T T +PYY+APE Sbjct: 156 IQFLHSRNIAHRDVKPENLLYTSKDKDAVLKLTDFGFAKETTQNALQTPCY-TPYYVAPE 214 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV----IDFKRDPWPR 361 VL Y + D+WS GVI+YILLCG PPF++ T Q ++ + R + F W Sbjct: 215 VLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPSPEWSE 274 Query: 362 VSDNAKDLVRGML 400 VS++AK L+R +L Sbjct: 275 VSEDAKQLIRLLL 287
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 105 bits (261), Expect = 3e-23 Identities = 53/137 (38%), Positives = 77/137 (56%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H + ++HRDLKPEN L + + ++ DFG S PGE+ E+ G+P Y+A Sbjct: 139 EAVNFLHVNNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLRELCGTPGYLA 195 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+LK + YG+EVD+W+ GVIL+ LL G PPFW + + + I+ F Sbjct: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255 Query: 350 PWPRVSDNAKDLVRGML 400 W S+ KDL+ +L Sbjct: 256 EWDDRSNTVKDLIAKLL 272
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 105 bits (261), Expect = 3e-23 Identities = 53/137 (38%), Positives = 76/137 (55%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H + ++HRDLKPEN L + + ++ DFG S PGE+ E+ G+P Y+A Sbjct: 139 EAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLRELCGTPGYLA 195 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+LK + YG+EVD+W+ GVIL+ LL G PPFW + + + I+ F Sbjct: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255 Query: 350 PWPRVSDNAKDLVRGML 400 W S KDL+ +L Sbjct: 256 EWDDRSSTVKDLISRLL 272
>MAPK2_CRILO (P49136) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (P45-54 HSP27 kinase) (Fragment) Length = 329 Score = 103 bits (257), Expect = 1e-22 Identities = 54/135 (40%), Positives = 73/135 (54%), Gaps = 5/135 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E +Q H + HRD+KPEN L+ +K+ A LK DFG + T T +PYY+A Sbjct: 101 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 160 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAE----TEQGVAQAIIRSVIDFKRDPW 355 PEVL Y + D+WS GVI+YILLCG PPF++ G+ I +F W Sbjct: 161 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 220 Query: 356 PRVSDNAKDLVRGML 400 VS+ K L+R +L Sbjct: 221 SEVSEEVKMLIRNLL 235
>MAPK2_MOUSE (P49138) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 386 Score = 103 bits (257), Expect = 1e-22 Identities = 54/135 (40%), Positives = 73/135 (54%), Gaps = 5/135 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E +Q H + HRD+KPEN L+ +K+ A LK DFG + T T +PYY+A Sbjct: 158 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 217 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAE----TEQGVAQAIIRSVIDFKRDPW 355 PEVL Y + D+WS GVI+YILLCG PPF++ G+ I +F W Sbjct: 218 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 277 Query: 356 PRVSDNAKDLVRGML 400 VS+ K L+R +L Sbjct: 278 SEVSEEVKMLIRNLL 292
>MAPK2_HUMAN (P49137) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 400 Score = 103 bits (257), Expect = 1e-22 Identities = 54/135 (40%), Positives = 73/135 (54%), Gaps = 5/135 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E +Q H + HRD+KPEN L+ +K+ A LK DFG + T T +PYY+A Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAE----TEQGVAQAIIRSVIDFKRDPW 355 PEVL Y + D+WS GVI+YILLCG PPF++ G+ I +F W Sbjct: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 Query: 356 PRVSDNAKDLVRGML 400 VS+ K L+R +L Sbjct: 292 SEVSEEVKMLIRNLL 306
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 102 bits (255), Expect = 2e-22 Identities = 52/137 (37%), Positives = 76/137 (55%), Gaps = 7/137 (5%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H + ++HRDLKPEN L + + ++ DFG S GE+ E+ G+P Y+A Sbjct: 139 EAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEAGEKLRELCGTPGYLA 195 Query: 191 PEVLKRN-------YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 PE+LK + YG+EVD+W+ GVIL+ LL G PPFW + + + I+ F Sbjct: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSP 255 Query: 350 PWPRVSDNAKDLVRGML 400 W S+ KDL+ +L Sbjct: 256 EWDDCSNTVKDLISKLL 272
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 102 bits (254), Expect = 2e-22 Identities = 53/131 (40%), Positives = 78/131 (59%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV--GSPYYMA 190 V+ H +G++HRDLKPEN L+ +K + L DFGLS F+ + + + G+P YMA Sbjct: 142 VKYLHDNGIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMA 201 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEV +R YG+ VD+W+ GVI Y LL G PF ++ V +AI+ + F W +S Sbjct: 202 PEVFRRTGYGKPVDMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGIS 261 Query: 368 DNAKDLVRGML 400 + AKD ++ L Sbjct: 262 ETAKDFIKKCL 272
>CSKP_MOUSE (O70589) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 924 Score = 100 bits (250), Expect = 6e-22 Identities = 56/136 (41%), Positives = 84/136 (61%), Gaps = 6/136 (4%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFF-----TPGERFTEIVGS 175 E ++ CH + ++HRD+KP L A+K+ +A +K FG+++ G R VG+ Sbjct: 127 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGR----VGT 182 Query: 176 PYYMAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDP 352 P++MAPEV+KR YG+ VDVW GVIL+ILL G PF+ T++ + + II+ Sbjct: 183 PHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQ 241 Query: 353 WPRVSDNAKDLVRGML 400 W +S++AKDLVR ML Sbjct: 242 WSHISESAKDLVRRML 257
>CSKP_RAT (Q62915) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 909 Score = 100 bits (250), Expect = 6e-22 Identities = 56/136 (41%), Positives = 84/136 (61%), Gaps = 6/136 (4%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFF-----TPGERFTEIVGS 175 E ++ CH + ++HRD+KP L A+K+ +A +K FG+++ G R VG+ Sbjct: 127 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGR----VGT 182 Query: 176 PYYMAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDP 352 P++MAPEV+KR YG+ VDVW GVIL+ILL G PF+ T++ + + II+ Sbjct: 183 PHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQ 241 Query: 353 WPRVSDNAKDLVRGML 400 W +S++AKDLVR ML Sbjct: 242 WSHISESAKDLVRRML 257
>CSKP_HUMAN (O14936) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 100 bits (250), Expect = 6e-22 Identities = 56/136 (41%), Positives = 84/136 (61%), Gaps = 6/136 (4%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFF-----TPGERFTEIVGS 175 E ++ CH + ++HRD+KP L A+K+ +A +K FG+++ G R VG+ Sbjct: 127 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGR----VGT 182 Query: 176 PYYMAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDP 352 P++MAPEV+KR YG+ VDVW GVIL+ILL G PF+ T++ + + II+ Sbjct: 183 PHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQ 241 Query: 353 WPRVSDNAKDLVRGML 400 W +S++AKDLVR ML Sbjct: 242 WSHISESAKDLVRRML 257
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 100 bits (249), Expect = 8e-22 Identities = 52/125 (41%), Positives = 74/125 (59%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVL-K 205 HK ++HRDLKPEN LF N+++ + LK +DFGLS + + GS Y++PE L + Sbjct: 159 HKSTIIHRDLKPENCLFLNQEKRSTLKIMDFGLSSVEDFTDPIVALFGSIDYVSPEALSQ 218 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 R D+WS GVILYILL G PPF A + + Q I+ F+ W ++ +AKDL Sbjct: 219 RQVSSASDMWSLGVILYILLSGCPPFHAPSNREKQQRILAGDFSFEEHTWKTITSSAKDL 278 Query: 386 VRGML 400 + +L Sbjct: 279 ISSLL 283
>MAPK2_DROME (P49071) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) Length = 359 Score = 100 bits (248), Expect = 1e-21 Identities = 52/133 (39%), Positives = 69/133 (51%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V H + HRDLKPEN L+ + A LK DFG + +PYY+APE Sbjct: 130 VDYLHSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPE 189 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAE----TEQGVAQAIIRSVIDFKRDPWPR 361 VL Y + D+WS GV++YI++CG PPF++ G+ I DF W Sbjct: 190 VLGPEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTN 249 Query: 362 VSDNAKDLVRGML 400 VS AKDL++GML Sbjct: 250 VSQAAKDLIKGML 262
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 99.8 bits (247), Expect = 1e-21 Identities = 51/125 (40%), Positives = 71/125 (56%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 H ++HRDLKPEN L +K+ + DFGLS G+P Y+APEVL Sbjct: 122 HGLNIVHRDLKPENLLLKSKENHLEVAIADFGLSKIIGQTLVMQTACGTPSYVAPEVLNA 181 Query: 209 N-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 Y +EVD+WS GVI YILLCG PPF+ +T + + I+ + +F + W +S AKD Sbjct: 182 TGYDKEVDMWSIGVITYILLCGFPPFYGDTVPEIFEQIMEANYEFPEEYWGGISKEAKDF 241 Query: 386 VRGML 400 + +L Sbjct: 242 IGKLL 246
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 99.0 bits (245), Expect = 2e-21 Identities = 53/132 (40%), Positives = 83/132 (62%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFL-FANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 ++ H ++HRD+KPEN L + ++ + +LK DFGL+ G +T + G+P Y+AP Sbjct: 192 IKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI-VDGPLYT-VCGTPTYVAP 249 Query: 194 EVL-KRNYGQEVDVWSAGVILYILLCGVPPF--WAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ + YG +VD+W+AGVI YILLCG PPF + ++ + I+ +DF W V Sbjct: 250 EIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNV 309 Query: 365 SDNAKDLVRGML 400 SD+AK+L+ ML Sbjct: 310 SDSAKELINMML 321
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 99.0 bits (245), Expect = 2e-21 Identities = 53/132 (40%), Positives = 83/132 (62%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFL-FANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 ++ H ++HRD+KPEN L + ++ + +LK DFGL+ G +T + G+P Y+AP Sbjct: 515 IKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI-VDGPLYT-VCGTPTYVAP 572 Query: 194 EVL-KRNYGQEVDVWSAGVILYILLCGVPPF--WAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ + YG +VD+W+AGVI YILLCG PPF + ++ + I+ +DF W V Sbjct: 573 EIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNV 632 Query: 365 SDNAKDLVRGML 400 SD+AK+L+ ML Sbjct: 633 SDSAKELINMML 644
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 98.6 bits (244), Expect = 3e-21 Identities = 53/132 (40%), Positives = 83/132 (62%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFL-FANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 ++ H ++HRD+KPEN L + ++ + +LK DFGL+ G +T + G+P Y+AP Sbjct: 499 IKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI-VDGPLYT-VCGTPTYVAP 556 Query: 194 EVL-KRNYGQEVDVWSAGVILYILLCGVPPF--WAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ + YG +VD+W+AGVI YILLCG PPF + ++ + I+ +DF W V Sbjct: 557 EIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNV 616 Query: 365 SDNAKDLVRGML 400 SD+AK+L+ ML Sbjct: 617 SDSAKELITMML 628
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 98.2 bits (243), Expect = 4e-21 Identities = 54/133 (40%), Positives = 76/133 (57%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ H++G++HRDLKPEN L ++++E +K DFG S + G+P Y+APE Sbjct: 339 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPE 398 Query: 197 VLKRN----YGQEVDVWSAGVILYILLCGVPPFWA-ETEQGVAQAIIRSVIDFKRDPWPR 361 VL N Y + VD WS GVIL+I L G PPF +T+ + I +F + W Sbjct: 399 VLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTD 458 Query: 362 VSDNAKDLVRGML 400 VS+ A DLV+ +L Sbjct: 459 VSEEALDLVKKLL 471
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 97.8 bits (242), Expect = 5e-21 Identities = 53/128 (41%), Positives = 80/128 (62%), Gaps = 4/128 (3%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKE-TAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVL- 202 H ++HRD+KPEN L + T +LK DFGL+ G +T + G+P Y+APE++ Sbjct: 506 HSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATV-VEGPLYT-VCGTPTYVAPEIIA 563 Query: 203 KRNYGQEVDVWSAGVILYILLCGVPPFWAET--EQGVAQAIIRSVIDFKRDPWPRVSDNA 376 + YG +VDVW+AGVI YILLCG PPF +E ++ + I+ ++F W ++D+A Sbjct: 564 ETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 623 Query: 377 KDLVRGML 400 K+L+ ML Sbjct: 624 KELISQML 631
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 96.7 bits (239), Expect = 1e-20 Identities = 52/128 (40%), Positives = 80/128 (62%), Gaps = 4/128 (3%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKE-TAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVL- 202 H ++HRD+KPEN L + T +LK DFGL+ G +T + G+P Y+APE++ Sbjct: 507 HGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATV-VEGPLYT-VCGTPTYVAPEIIA 564 Query: 203 KRNYGQEVDVWSAGVILYILLCGVPPFWAET--EQGVAQAIIRSVIDFKRDPWPRVSDNA 376 + YG +VD+W+AGVI YILLCG PPF +E ++ + I+ ++F W ++D+A Sbjct: 565 ETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 624 Query: 377 KDLVRGML 400 K+L+ ML Sbjct: 625 KELISQML 632
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 96.3 bits (238), Expect = 2e-20 Identities = 53/133 (39%), Positives = 74/133 (55%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ H++G++HRDLKPEN L ++++E +K DFG S + G+P Y+APE Sbjct: 335 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPE 394 Query: 197 VL----KRNYGQEVDVWSAGVILYILLCGVPPFWA-ETEQGVAQAIIRSVIDFKRDPWPR 361 VL Y + VD WS GVIL+I L G PPF T+ + I +F + W Sbjct: 395 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAE 454 Query: 362 VSDNAKDLVRGML 400 VS+ A DLV+ +L Sbjct: 455 VSEKALDLVKKLL 467
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 96.3 bits (238), Expect = 2e-20 Identities = 50/128 (39%), Positives = 76/128 (59%), Gaps = 1/128 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 ++ H +GV+HRDLK EN + N + ++LK IDFGL+ F GSP Y+APE Sbjct: 218 LEALHSNGVVHRDLKMENLMLENPNDPSSLKIIDFGLASFLN-SPSMNMRCGSPGYVAPE 276 Query: 197 VLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 +LK +YG +VD++S GVIL+ +LCG PPF + + + +R I F W S++ Sbjct: 277 ILKCASYGTKVDIFSLGVILFNILCGYPPFRGNNVKEIFKKNMRCHISFNTKHWINKSES 336 Query: 374 AKDLVRGM 397 K+++ M Sbjct: 337 VKEIILWM 344
>MYLK_CHICK (P11799) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin] Length = 1906 Score = 95.1 bits (235), Expect = 3e-20 Identities = 51/133 (38%), Positives = 76/133 (57%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V+ HK G++H DLKPEN + NK T+ +K IDFGL+ + G+P ++A Sbjct: 1560 EGVEYIHKQGIVHLDLKPENIMCVNKTGTS-IKLIDFGLARRLESAGSLKVLFGTPEFVA 1618 Query: 191 PEVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PEV+ NY G E D+WS GVI YIL+ G+ PF + + + + DF + + Sbjct: 1619 PEVI--NYEPIGYETDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 1676 Query: 362 VSDNAKDLVRGML 400 +SD+AKD + +L Sbjct: 1677 ISDDAKDFISNLL 1689
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 94.7 bits (234), Expect = 5e-20 Identities = 54/130 (41%), Positives = 74/130 (56%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 + CHK V+HRDLKPEN +F K+ +K DFG S F PG++ T GS Y APE Sbjct: 127 ISYCHKLHVVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPE 184 Query: 197 VLKRNY--GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 +L + VD+WS GVIL++L+CG PPF ++ + ++D K PRVS Sbjct: 185 ILLGDEYDAPAVDIWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPPRVSA 240 Query: 371 NAKDLVRGML 400 +DL+ ML Sbjct: 241 GCRDLITRML 250
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 94.7 bits (234), Expect = 5e-20 Identities = 54/130 (41%), Positives = 74/130 (56%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 + CHK V+HRDLKPEN +F K+ +K DFG S F PG++ T GS Y APE Sbjct: 127 ISYCHKLHVVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPE 184 Query: 197 VLKRNY--GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 +L + VD+WS GVIL++L+CG PPF ++ + ++D K PRVS Sbjct: 185 ILLGDEYDAPAVDIWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPPRVSA 240 Query: 371 NAKDLVRGML 400 +DL+ ML Sbjct: 241 GCRDLITRML 250
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 94.0 bits (232), Expect = 8e-20 Identities = 51/132 (38%), Positives = 72/132 (54%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFF-TPGERFTEIVGSPYYM 187 + V H+ ++HRDLKPEN L+ + + L DFG++ P E T + GS Y Sbjct: 128 DAVNYLHQRNIVHRDLKPENLLYLTRDLDSQLVLADFGIAKMLDNPAEVLTSMAGSFGYA 187 Query: 188 APEV-LKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 APEV LK+ +G+ VD+WS GVI Y LLCG PF +E + + + F W V Sbjct: 188 APEVMLKQGHGKAVDIWSLGVITYTLLCGYSPFRSENLTDLIEECRSGRVVFHERYWKDV 247 Query: 365 SDNAKDLVRGML 400 S +AKD + +L Sbjct: 248 SKDAKDFILSLL 259
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 93.2 bits (230), Expect = 1e-19 Identities = 45/131 (34%), Positives = 73/131 (55%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H H V+H DLKP+N L ++ +K +DFGLS E EI+G+P Y+A Sbjct: 155 EGVHFLHTHDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRIVKNSEELREIMGTPEYVA 214 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+L + D+WS GV+ Y++L G+ PF + +Q I + + + + + VS Sbjct: 215 PEILSYDPISMATDMWSIGVLTYVMLTGISPFLGDNKQETFLNISQMNLSYSEEEFDTVS 274 Query: 368 DNAKDLVRGML 400 ++A D ++ +L Sbjct: 275 ESAVDFIKKLL 285
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 92.8 bits (229), Expect = 2e-19 Identities = 52/132 (39%), Positives = 67/132 (50%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ H G+ HRDLKP+N L E LK DFGLS F + G+P Y+APE Sbjct: 291 VKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPE 350 Query: 197 VL----KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 VL + Y ++VD+WS GV+L+ L G PF E AQ I + + W V Sbjct: 351 VLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSV 410 Query: 365 SDNAKDLVRGML 400 S AK L+ ML Sbjct: 411 SQRAKLLINQML 422
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 92.0 bits (227), Expect = 3e-19 Identities = 50/131 (38%), Positives = 72/131 (54%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYYMA 190 V+ H G+ HRDLKPEN L+ + + + DFGL+ G+ G+P Y+A Sbjct: 204 VKYLHTLGITHRDLKPENLLYYHPGADSKIMITDFGLASTRKKGDECLMKTTCGTPEYIA 263 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+L R Y VD+W+ GVI YILL G PF + + + I++ F +PWP VS Sbjct: 264 PEILVRKPYTNAVDMWALGVISYILLSGTMPFEDDNRMRLYRQILKGKYSFSGEPWPSVS 323 Query: 368 DNAKDLVRGML 400 + AKD + +L Sbjct: 324 NLAKDFIDRVL 334
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 92.0 bits (227), Expect = 3e-19 Identities = 53/133 (39%), Positives = 77/133 (57%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV----GSPYY 184 ++ H+ ++HRDLKPEN LF + + ++LK +DFGLS E FT+ V GS Y Sbjct: 167 LEAIHRANIIHRDLKPENCLFLDVGKDSSLKIMDFGLSSV----EEFTDPVVGLFGSIDY 222 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PE L + + D+WS GVILYILL G PPF A+ + Q I+ F W Sbjct: 223 VSPEALSQGKITTKSDMWSLGVILYILLSGYPPFIAQNNRQKQQMILNGNFSFYEKTWKG 282 Query: 362 VSDNAKDLVRGML 400 +S +AK+L+ +L Sbjct: 283 ISQSAKNLISSLL 295
>MAPK2_RABIT (P49139) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) (Fragments) Length = 330 Score = 92.0 bits (227), Expect = 3e-19 Identities = 44/94 (46%), Positives = 58/94 (61%), Gaps = 1/94 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E +Q H + HRD+KPEN L+ +K+ A LK DFG + T T +PYY+A Sbjct: 138 EAIQYLHSINIAHRDVKPENLLYTSKRPKAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 197 Query: 191 PEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWA 289 PEVL Y + D+WS GVI+YILLCG PPF++ Sbjct: 198 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYS 231
>CAKI_DROME (Q24210) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CAKI) (Peripheral plasma membrane protein CaMGUK) Length = 898 Score = 92.0 bits (227), Expect = 3e-19 Identities = 55/135 (40%), Positives = 78/135 (57%), Gaps = 5/135 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT----EIVGSP 178 E ++ CH++ ++HRD++P L A +A +K FG S PG R T VG P Sbjct: 127 EALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFG-SAIQLPGTRETIETHGRVGCP 185 Query: 179 YYMAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPW 355 +YMAPEV+ R YG+ DVW AGV+L++LL G PF + + Q++ R + F+ W Sbjct: 186 HYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVR-LQQSVARGRLSFEAPEW 244 Query: 356 PRVSDNAKDLVRGML 400 +S NAKDLV ML Sbjct: 245 KSISANAKDLVMKML 259
>MYLK_MOUSE (Q6PDN3) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1941 Score = 91.7 bits (226), Expect = 4e-19 Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V+ HK G++H DLKPEN + NK T +K IDFGL+ + G+P ++A Sbjct: 1593 EGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVA 1651 Query: 191 PEVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PEV+ NY G D+WS GVI YIL+ G+ PF + + + + DF + + Sbjct: 1652 PEVI--NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 1709 Query: 362 VSDNAKDLVRGML 400 +SD+AKD + +L Sbjct: 1710 ISDDAKDFISNLL 1722
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 91.7 bits (226), Expect = 4e-19 Identities = 51/131 (38%), Positives = 72/131 (54%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYYMA 190 V+ H G+ HRDLKPEN L+ + + + DFGL+ G+ G+P Y+A Sbjct: 205 VRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIA 264 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL R Y VD+W+ GVI YILL G PF + + + I+R + +PWP VS Sbjct: 265 PEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVS 324 Query: 368 DNAKDLVRGML 400 + AKD + +L Sbjct: 325 NLAKDFIDRLL 335
>MYLK_HUMAN (Q15746) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1914 Score = 91.7 bits (226), Expect = 4e-19 Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V+ HK G++H DLKPEN + NK T +K IDFGL+ + G+P ++A Sbjct: 1571 EGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVA 1629 Query: 191 PEVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PEV+ NY G D+WS GVI YIL+ G+ PF + + + + DF + + Sbjct: 1630 PEVI--NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 1687 Query: 362 VSDNAKDLVRGML 400 +SD+AKD + +L Sbjct: 1688 ISDDAKDFISNLL 1700
>MYLK_SHEEP (O02827) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] (Fragment) Length = 438 Score = 91.7 bits (226), Expect = 4e-19 Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V+ HK G++H DLKPEN + NK T +K IDFGL+ + G+P ++A Sbjct: 93 EGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVA 151 Query: 191 PEVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PEV+ NY G D+WS GVI YIL+ G+ PF + + + + DF + + Sbjct: 152 PEVI--NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 209 Query: 362 VSDNAKDLVRGML 400 +SD+AKD + +L Sbjct: 210 ISDDAKDFISNLL 222
>MYLK_BOVIN (Q28824) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1176 Score = 91.7 bits (226), Expect = 4e-19 Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V+ HK G++H DLKPEN + NK T +K IDFGL+ + G+P ++A Sbjct: 832 EGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVA 890 Query: 191 PEVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PEV+ NY G D+WS GVI YIL+ G+ PF + + + + DF + + Sbjct: 891 PEVI--NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 948 Query: 362 VSDNAKDLVRGML 400 +SD+AKD + +L Sbjct: 949 ISDDAKDFISNLL 961
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 91.3 bits (225), Expect = 5e-19 Identities = 53/130 (40%), Positives = 72/130 (55%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 + CHK V+HRDLKPEN +F K+ +K DFG S F PG++ T GS Y APE Sbjct: 127 ISYCHKLHVVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPE 184 Query: 197 VLKRNY--GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 +L + VD+WS GVIL++L+CG PPF ++ + ++D K VS Sbjct: 185 ILLGDEYDAPAVDIWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPSHVSK 240 Query: 371 NAKDLVRGML 400 KDL+ ML Sbjct: 241 ECKDLITRML 250
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 91.3 bits (225), Expect = 5e-19 Identities = 53/133 (39%), Positives = 76/133 (57%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV----GSPYY 184 ++ H+ ++HRDLKPEN LF + ++ + LK +DFGLS E FT+ V GS Y Sbjct: 159 LEAVHRANIVHRDLKPENCLFLDVRKDSPLKIMDFGLSSV----EEFTDPVVGLFGSIDY 214 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 ++PE L + + D+WS GVILYILL G PPF A+ + Q I+ F W Sbjct: 215 VSPEALSQGKITTKSDMWSLGVILYILLSGYPPFIAQNNRQKQQMIMNGNFSFYEKTWKG 274 Query: 362 VSDNAKDLVRGML 400 +S AK+L+ +L Sbjct: 275 ISQPAKNLISSLL 287
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 90.9 bits (224), Expect = 7e-19 Identities = 51/131 (38%), Positives = 72/131 (54%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYYMA 190 V+ H G+ HRDLKPEN L+ + + + DFGL+ G+ G+P Y+A Sbjct: 205 VRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIA 264 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL R Y VD+W+ GVI YILL G PF + + + I+R + +PWP VS Sbjct: 265 PEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYLGEPWPSVS 324 Query: 368 DNAKDLVRGML 400 + AKD + +L Sbjct: 325 NLAKDFIDRLL 335
>MAPK5_MOUSE (O54992) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) Length = 473 Score = 90.9 bits (224), Expect = 7e-19 Identities = 51/152 (33%), Positives = 80/152 (52%), Gaps = 24/152 (15%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 +Q CH + HRDLKPEN LF + A +K DFG + G+ T +PYY+AP+ Sbjct: 136 LQHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKV-DQGDLMTPQF-TPYYVAPQ 193 Query: 197 VLKRN-------------------YGQEVDVWSAGVILYILLCGVPPFWAE-----TEQG 304 VL+ Y + D+WS GVI+Y++LCG PPF+++ + Sbjct: 194 VLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKD 253 Query: 305 VAQAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 + + I+ +F + W ++S+ AKD+VR +L Sbjct: 254 MRKKIMTGSFEFPEEEWSQISEMAKDVVRKLL 285
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 90.9 bits (224), Expect = 7e-19 Identities = 48/92 (52%), Positives = 58/92 (63%), Gaps = 3/92 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLF-ANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V CH H ++HRDLKPEN L ANK +K DFGLS + T G+ + GSP Y AP Sbjct: 135 VSYCHNHMIVHRDLKPENLLLDANKN----IKIADFGLSNYMTDGDLLSTACGSPNYAAP 190 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPF 283 E++ K G EVD+WS GVILY +LCG PF Sbjct: 191 ELISNKLYVGPEVDLWSCGVILYAMLCGTLPF 222
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 90.5 bits (223), Expect = 9e-19 Identities = 56/130 (43%), Positives = 71/130 (54%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH+H ++HRDLKPEN L ++ +K DFGLS T G GSP Y APE Sbjct: 162 VEYCHRHKIVHRDLKPENLLLDDQLN---VKIADFGLSNIMTDGNFLKTSCGSPNYAAPE 218 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V+ K G EVDVWS+GVILY++LCG PF E + + I V +S Sbjct: 219 VISGKLYAGPEVDVWSSGVILYVMLCGRLPFDDEFIPALFKKISNGVYTLPN----YLSP 274 Query: 371 NAKDLVRGML 400 AK L+ ML Sbjct: 275 GAKHLLTRML 284
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 90.5 bits (223), Expect = 9e-19 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L + +K DFGLS T G+ GSP Y APE Sbjct: 198 VDYCHRHMVVHRDLKPENLLLDEQNN---VKIADFGLSNIMTDGDFLRTSCGSPNYAAPE 254 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPF 283 V+ K G EVDVWS GVILY LLCG PF Sbjct: 255 VISGKLYAGPEVDVWSCGVILYALLCGTLPF 285
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 90.5 bits (223), Expect = 9e-19 Identities = 52/130 (40%), Positives = 73/130 (56%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH H ++HRDLK EN L + + +K DFG F+ PGE + VGSP Y APE Sbjct: 137 VEYCHNHHIVHRDLKTENLLLDSNMD---IKLADFGFGNFYKPGEPLSTCVGSPPYAAPE 193 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V K G ++DVWS GV+LY+L+CG PF + Q ++ R P+ +S Sbjct: 194 VFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF---RIPF-FMSQ 249 Query: 371 NAKDLVRGML 400 + + L+R ML Sbjct: 250 DCETLIRRML 259
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 90.1 bits (222), Expect = 1e-18 Identities = 56/130 (43%), Positives = 71/130 (54%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH+H ++HRDLKPEN L E +K DFGLS T G GSP Y APE Sbjct: 149 VEYCHRHKIVHRDLKPENLLL---DEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPE 205 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V+ K G EVDVWS GVILY++LC PF E+ + + I V + +S Sbjct: 206 VISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPK----FLSP 261 Query: 371 NAKDLVRGML 400 A DL++ ML Sbjct: 262 GASDLIKRML 271
>MAPK5_HUMAN (Q8IW41) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase) Length = 473 Score = 89.7 bits (221), Expect = 1e-18 Identities = 50/149 (33%), Positives = 78/149 (52%), Gaps = 24/149 (16%) Frame = +2 Query: 26 CHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 CH + HRDLKPEN LF + A +K DFG + G+ T +PYY+AP+VL+ Sbjct: 139 CHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKI-DQGDLMTPQF-TPYYVAPQVLE 196 Query: 206 RN-------------------YGQEVDVWSAGVILYILLCGVPPFWAE-----TEQGVAQ 313 Y + D+WS GVI+Y++LCG PPF+++ + + + Sbjct: 197 AQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRR 256 Query: 314 AIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 I+ +F + W ++S+ AKD+VR +L Sbjct: 257 KIMTGSFEFPEEEWSQISEMAKDVVRKLL 285
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 89.4 bits (220), Expect = 2e-18 Identities = 52/132 (39%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + +K +K IDFG++ G F I G+P ++AP Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 186 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF ET+Q I DF + + Sbjct: 187 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNT 244 Query: 365 SDNAKDLVRGML 400 S+ AKD +R +L Sbjct: 245 SELAKDFIRRLL 256
>MYLK_RABIT (P29294) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1147 Score = 89.4 bits (220), Expect = 2e-18 Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V+ HK G++H DLKPEN + NK T +K IDFGL+ + G+P ++A Sbjct: 803 EGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVA 861 Query: 191 PEVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PEV+ NY D+WS GVI YIL+ G+ PF + + + + DF + + Sbjct: 862 PEVI--NYEPISYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE 919 Query: 362 VSDNAKDLVRGML 400 +SD+AKD + +L Sbjct: 920 ISDDAKDFISNLL 932
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 89.4 bits (220), Expect = 2e-18 Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAA-LKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + +K + +K IDFG++ G F I G+P ++AP Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAP 186 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF ET+Q I DF + + Sbjct: 187 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSST 244 Query: 365 SDNAKDLVRGML 400 S+ AKD +R +L Sbjct: 245 SELAKDFIRRLL 256
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 89.4 bits (220), Expect = 2e-18 Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAA-LKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + +K + +K IDFG++ G F I G+P ++AP Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAP 186 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF ET+Q I DF + + Sbjct: 187 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSST 244 Query: 365 SDNAKDLVRGML 400 S+ AKD +R +L Sbjct: 245 SELAKDFIRRLL 256
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 89.0 bits (219), Expect = 2e-18 Identities = 49/92 (53%), Positives = 59/92 (64%), Gaps = 3/92 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYM-AP 193 V+ CH+H ++HRDLKPEN L ++ +K DFGLS T G GSP YM AP Sbjct: 163 VEYCHRHKIVHRDLKPENLLLDDQLN---VKIADFGLSNIMTDGNFLKTSCGSPNYMPAP 219 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPF 283 EV+ K G EVDVWSAGVILY++LCG PF Sbjct: 220 EVISGKLYAGPEVDVWSAGVILYVMLCGRLPF 251
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 88.6 bits (218), Expect = 3e-18 Identities = 44/131 (33%), Positives = 71/131 (54%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H V+H DLKP+N L ++ +K +DFGLS E EI+G+P Y+A Sbjct: 172 EGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVA 231 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+L + D+WS GV+ Y++L G+ PF +Q I + + + + + +S Sbjct: 232 PEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLS 291 Query: 368 DNAKDLVRGML 400 ++A D +R +L Sbjct: 292 ESAVDFIRTLL 302
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 88.6 bits (218), Expect = 3e-18 Identities = 56/130 (43%), Positives = 69/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH++ V+HRDLKPEN L +K +K DFGLS G GSP Y APE Sbjct: 153 VEYCHRNMVVHRDLKPENLLLDSK---CNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPE 209 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V+ K G EVDVWS GVILY LLCG PF E + + I + +S Sbjct: 210 VISGKLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLP----SHLSP 265 Query: 371 NAKDLVRGML 400 A+DL+ ML Sbjct: 266 GARDLIPRML 275
>KCC1_METAN (O14408) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| Length = 382 Score = 88.6 bits (218), Expect = 3e-18 Identities = 49/130 (37%), Positives = 72/130 (55%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 V H + V+HRDLKPEN L+ + + L DFG++ E T + GS Y AP Sbjct: 130 VDYLHDNDVVHRDLKPENLLYVTRDPDSDLVLADFGITKTLDIKEETLTTMAGSFGYAAP 189 Query: 194 EVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 EV++ + +G+ VD+WS GVI Y LLCG PF +E + + + + + F W VS Sbjct: 190 EVMEQKGHGKPVDMWSMGVITYTLLCGYSPFRSENLRDLLRECTAAPVPFHERYWKDVSQ 249 Query: 371 NAKDLVRGML 400 +AKD + +L Sbjct: 250 DAKDFILVLL 259
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 88.6 bits (218), Expect = 3e-18 Identities = 54/131 (41%), Positives = 77/131 (58%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E + CH V+HRD+KPEN L + E LK DFG SV P R T + G+ Y+ Sbjct: 249 EALLYCHSKKVIHRDIKPENLLLGSNGE---LKIADFGWSVH-APSSRRTTLCGTLDYLP 304 Query: 191 PEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+++ R + ++VD+WS GV+ Y L G PPF +T Q + I S ++F+ P+ VS Sbjct: 305 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFETDTHQETYRRI--SKVEFQYPPY--VS 360 Query: 368 DNAKDLVRGML 400 + AKDLV +L Sbjct: 361 EEAKDLVSKLL 371
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 87.8 bits (216), Expect = 6e-18 Identities = 52/140 (37%), Positives = 75/140 (53%), Gaps = 12/140 (8%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSP----YY 184 V H GV+HRDLKPEN LF ++ + +K IDFG F P + + +P +Y Sbjct: 532 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFG---FARPKPPDNQPLKTPCFTLHY 588 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQ-------GVAQAIIRSVIDF 340 APE+L +N Y + D+WS GVILY +L G PF + + + I + F Sbjct: 589 AAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSF 648 Query: 341 KRDPWPRVSDNAKDLVRGML 400 + + W VS AKDL++G+L Sbjct: 649 EGEAWKNVSQEAKDLIQGLL 668 Score = 66.6 bits (161), Expect = 1e-11 Identities = 45/130 (34%), Positives = 70/130 (53%), Gaps = 6/130 (4%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE--RFTEIVGSPYYMAPEVL 202 HK G+++RD+K EN L + + DFGLS F E R G+ YMAP+++ Sbjct: 169 HKLGIIYRDIKLENILLDSNGH---VMLTDFGLSKEFVADETERAYSFCGTIEYMAPDIV 225 Query: 203 K---RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR-VSD 370 + + + VD WS GV++Y LL G PF + E+ I R ++ P+P+ +S Sbjct: 226 RGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILK-SEPPYPQEMSA 284 Query: 371 NAKDLVRGML 400 AKDL++ +L Sbjct: 285 LAKDLIQHLL 294
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 87.8 bits (216), Expect = 6e-18 Identities = 55/130 (42%), Positives = 69/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH++ V+HRDLKPEN L ++ +K DFGLS G GSP Y APE Sbjct: 131 VEYCHRNMVVHRDLKPENLLLDSR---CNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPE 187 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V+ K G EVDVWS GVILY LLCG PF E + + I + +S Sbjct: 188 VISGKLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLP----SHLSS 243 Query: 371 NAKDLVRGML 400 A+DL+ ML Sbjct: 244 EARDLIPRML 253
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 87.8 bits (216), Expect = 6e-18 Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + +K +K IDFGL+ G F I G+P ++AP Sbjct: 137 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 196 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF +T+Q I DF + + + Sbjct: 197 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 254 Query: 365 SDNAKDLVRGML 400 S+ AKD +R +L Sbjct: 255 SELAKDFIRKLL 266
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 87.8 bits (216), Expect = 6e-18 Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + +K +K IDFGL+ G F I G+P ++AP Sbjct: 137 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 196 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF +T+Q I DF + + + Sbjct: 197 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 254 Query: 365 SDNAKDLVRGML 400 S+ AKD +R +L Sbjct: 255 SELAKDFIRKLL 266
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 87.4 bits (215), Expect = 7e-18 Identities = 50/137 (36%), Positives = 73/137 (53%), Gaps = 9/137 (6%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTP-GERFTEIVGSPYYMAP 193 V H GV+HRDLKPEN LF ++ + +K IDFG + P + + +Y AP Sbjct: 532 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAP 591 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQ-------GVAQAIIRSVIDFKRD 349 E+L +N Y + D+WS GVILY +L G PF + + + I + F+ + Sbjct: 592 ELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGE 651 Query: 350 PWPRVSDNAKDLVRGML 400 W VS AKDL++G+L Sbjct: 652 AWKNVSQEAKDLIQGLL 668 Score = 66.6 bits (161), Expect = 1e-11 Identities = 45/130 (34%), Positives = 69/130 (53%), Gaps = 6/130 (4%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE--RFTEIVGSPYYMAPEVL 202 HK G+++RD+K EN L + DFGLS F E R G+ YMAP+++ Sbjct: 169 HKLGIIYRDIKLENILLDSNGHVVLT---DFGLSKEFVADETERAYSFCGTIEYMAPDIV 225 Query: 203 K---RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR-VSD 370 + + + VD WS GV++Y LL G PF + E+ I R ++ P+P+ +S Sbjct: 226 RGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILK-SEPPYPQEMSA 284 Query: 371 NAKDLVRGML 400 AKDL++ +L Sbjct: 285 LAKDLIQRLL 294
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 87.4 bits (215), Expect = 7e-18 Identities = 49/130 (37%), Positives = 72/130 (55%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV-GSPYYMAP 193 V+ H G+ HRDLKPEN L+ + + + DFGLS E F G+P Y+AP Sbjct: 186 VKYLHGLGITHRDLKPENLLYYHPGHDSKIMITDFGLSSTRKGPENFMRTTCGTPEYIAP 245 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 E++ R Y +VD+W+ GVI YILL G PF E + + + I+++ + + W VS Sbjct: 246 EIIARKPYMCQVDMWAVGVITYILLSGTMPFDDENKTRLYRLILKAKYSYAGEHWKDVSA 305 Query: 371 NAKDLVRGML 400 AKD + +L Sbjct: 306 QAKDFIDKLL 315
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 87.4 bits (215), Expect = 7e-18 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L + K DFGLS + GE GSP Y APE Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAQMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS GVILY LLCG PF Sbjct: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPF 214
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 87.4 bits (215), Expect = 7e-18 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L + K DFGLS + GE GSP Y APE Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAQMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS GVILY LLCG PF Sbjct: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPF 214
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 87.0 bits (214), Expect = 9e-18 Identities = 58/158 (36%), Positives = 77/158 (48%), Gaps = 31/158 (19%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 ++ CH+H ++HRDLKPEN L + +K DFGLS T G GSP Y APE Sbjct: 144 IEYCHRHKIVHRDLKPENLLL---DDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPE 200 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGV------------------AQA 316 V+ K G EVDVWS G++LY++L G PF E + AQ+ Sbjct: 201 VINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQS 260 Query: 317 IIRSVI-----------DFKRDPWPRVSDNAKDLVRGM 397 +IR +I + +RDPW V N D +R M Sbjct: 261 LIRRMIVADPMQRITIQEIRRDPWFNV--NLPDYLRPM 296
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 87.0 bits (214), Expect = 9e-18 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L K DFGLS + GE GSP Y APE Sbjct: 129 VDYCHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 185 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS+GVILY LLCG PF Sbjct: 186 VISGRLYAGPEVDIWSSGVILYALLCGTLPF 216
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 87.0 bits (214), Expect = 9e-18 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L K DFGLS + GE GSP Y APE Sbjct: 129 VDYCHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 185 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS+GVILY LLCG PF Sbjct: 186 VISGRLYAGPEVDIWSSGVILYALLCGTLPF 216
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 87.0 bits (214), Expect = 9e-18 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L K DFGLS + GE GSP Y APE Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS+GVILY LLCG PF Sbjct: 184 VISGRLYAGPEVDIWSSGVILYALLCGTLPF 214
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 87.0 bits (214), Expect = 9e-18 Identities = 49/91 (53%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L K DFGLS + GE GSP Y APE Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS+GVILY LLCG PF Sbjct: 184 VISGRLYAGPEVDIWSSGVILYALLCGTLPF 214
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 87.0 bits (214), Expect = 9e-18 Identities = 50/130 (38%), Positives = 71/130 (54%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH H ++HRDLK EN L + +K DFG F+ PGE + GSP Y APE Sbjct: 137 VEYCHNHHIVHRDLKTENLLLDGNMD---IKLADFGFGNFYKPGEPLSTWCGSPPYAAPE 193 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V K G ++D+WS GV+LY+L+CG PF + Q ++ R P+ +S Sbjct: 194 VFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF---RIPF-FMSQ 249 Query: 371 NAKDLVRGML 400 + + L+R ML Sbjct: 250 DCETLIRRML 259
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 87.0 bits (214), Expect = 9e-18 Identities = 47/91 (51%), Positives = 55/91 (60%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH+H ++HRDLKPEN L E +K DFGLS T G GSP Y APE Sbjct: 165 VEYCHRHKIVHRDLKPENLLL---DEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPE 221 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPF 283 V+ K G EVDVWS GVILY++LC PF Sbjct: 222 VISGKLYAGPEVDVWSCGVILYVMLCRRLPF 252
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 87.0 bits (214), Expect = 9e-18 Identities = 50/137 (36%), Positives = 72/137 (52%), Gaps = 9/137 (6%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTP-GERFTEIVGSPYYMAP 193 V H GV+HRDLKPEN LF ++ + +K IDFG + P + + +Y AP Sbjct: 596 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAP 655 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQ-------GVAQAIIRSVIDFKRD 349 E+L N Y + D+WS GVILY +L G PF + + + I + F+ + Sbjct: 656 ELLTHNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGE 715 Query: 350 PWPRVSDNAKDLVRGML 400 W VS AKDL++G+L Sbjct: 716 AWKNVSQEAKDLIQGLL 732 Score = 66.2 bits (160), Expect = 2e-11 Identities = 45/130 (34%), Positives = 69/130 (53%), Gaps = 6/130 (4%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE--RFTEIVGSPYYMAPEVL 202 HK G+++RD+K EN L + DFGLS F E R G+ YMAP+++ Sbjct: 168 HKLGIIYRDIKLENILLDSNGHVVLT---DFGLSKEFVADETERAYSFCGTIEYMAPDIV 224 Query: 203 K---RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR-VSD 370 + + + VD WS GV++Y LL G PF + E+ I R ++ P+P+ +S Sbjct: 225 RGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILK-SEPPYPQEMST 283 Query: 371 NAKDLVRGML 400 AKDL++ +L Sbjct: 284 VAKDLLQRLL 293
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 86.7 bits (213), Expect = 1e-17 Identities = 53/131 (40%), Positives = 76/131 (58%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E + CH V+HRD+KPEN L + E LK DFG SV P R T + G+ Y+ Sbjct: 249 EALLYCHSKKVIHRDIKPENLLLGSNGE---LKIADFGWSVH-APSSRRTTLCGTLDYLP 304 Query: 191 PEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+++ R + + VD+WS GV+ Y L G PPF +T Q + I S ++F+ P+ VS Sbjct: 305 PEMIEGRMHDETVDLWSLGVLCYEFLVGKPPFETDTHQETYRRI--SKVEFQYPPY--VS 360 Query: 368 DNAKDLVRGML 400 + A+DLV +L Sbjct: 361 EEARDLVSKLL 371
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 86.7 bits (213), Expect = 1e-17 Identities = 49/91 (53%), Positives = 54/91 (59%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L K DFGLS + GE GSP Y APE Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNIMSDGEFLRTSCGSPNYAAPE 183 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS GVILY LLCG PF Sbjct: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPF 214
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 86.7 bits (213), Expect = 1e-17 Identities = 49/91 (53%), Positives = 54/91 (59%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+H V+HRDLKPEN L K DFGLS + GE GSP Y APE Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPF 283 V+ R Y G EVD+WS GVILY LLCG PF Sbjct: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPF 214
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 86.7 bits (213), Expect = 1e-17 Identities = 48/137 (35%), Positives = 75/137 (54%), Gaps = 9/137 (6%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTP-GERFTEIVGSPYYMAP 193 V H GV+HRDLKPEN LF ++ + + +K IDFG + P + + +Y AP Sbjct: 522 VSHMHDVGVVHRDLKPENLLFTDETDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAP 581 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQ-------GVAQAIIRSVIDFKRD 349 E+ N Y + D+WS GVILY +L G PF ++ + + + I + F+ + Sbjct: 582 ELFNHNGYDESCDLWSLGVILYTMLSGQVPFQSQDKSLTCTSALEIMKKIKKGEFSFEGE 641 Query: 350 PWPRVSDNAKDLVRGML 400 W VS+ AK+L++G+L Sbjct: 642 AWKNVSEEAKELIQGLL 658 Score = 64.7 bits (156), Expect = 5e-11 Identities = 43/130 (33%), Positives = 69/130 (53%), Gaps = 6/130 (4%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTP--GERFTEIVGSPYYMAPEVL 202 HK G+++RD+K EN L + DFGLS F ER G+ YMAP+++ Sbjct: 159 HKLGIIYRDIKLENILLDSDGHVVLT---DFGLSKEFLTDENERAYSFCGTIEYMAPDIV 215 Query: 203 K---RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR-VSD 370 + + + VD WS GV++Y LL G PF + E+ I R ++ P+P+ +S Sbjct: 216 RGGDTGHDKAVDWWSVGVLMYELLTGASPFTVDGEKNSQAEISRRILK-SEPPYPQEMSA 274 Query: 371 NAKDLVRGML 400 +KD+++ +L Sbjct: 275 LSKDIIQRLL 284
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 85.9 bits (211), Expect = 2e-17 Identities = 47/131 (35%), Positives = 74/131 (56%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT--EIVGSPYYMA 190 ++ H + HR+LKPEN L+ + E + + DFGL+ +T + G+P Y+A Sbjct: 171 IRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIA 230 Query: 191 PEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PEVL R Y VD+W+ GVI Y LL G PF E++ + + I++ ++ +PWP +S Sbjct: 231 PEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSIS 290 Query: 368 DNAKDLVRGML 400 AKD + +L Sbjct: 291 HLAKDFIDKLL 301
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 85.5 bits (210), Expect = 3e-17 Identities = 51/131 (38%), Positives = 72/131 (54%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E + H ++HRD+KPEN L +K DFG SV P R + + G+ Y+ Sbjct: 208 EALLYLHGKNIIHRDIKPENILLHFND---TIKISDFGWSVH-APSNRRSTLCGTMDYLP 263 Query: 191 PEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+++ R Y + VDVWS G+++Y LCG PPF E G AQA R ++ P VS Sbjct: 264 PEIVQSRPYDKNVDVWSLGILMYEFLCGAPPF---EEPGGAQATYRRIVKLDLRIPPYVS 320 Query: 368 DNAKDLVRGML 400 +A DL++ ML Sbjct: 321 ADAADLIKRML 331
>MEK1_SCHPO (Q10292) Meiosis-specific serine/threonine-protein kinase mek1 (EC| 2.7.11.1) Length = 445 Score = 85.5 bits (210), Expect = 3e-17 Identities = 48/137 (35%), Positives = 73/137 (53%), Gaps = 13/137 (9%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETA-ALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 H+ ++HRDLK EN L A+ +T + DFG++ G+R + VG+P Y APE+ + Sbjct: 273 HEQNIIHRDLKLENILIASSSDTIFRIILTDFGVARCMQKGKRLSTFVGTPEYTAPEIQR 332 Query: 206 ------------RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRD 349 YG+EVD+WS GVI+++LL G P +A+ + +DF+ Sbjct: 333 LKGRSQVEKENSSGYGKEVDLWSLGVIMFLLLSGNSPSFAD-------GVKEKQVDFRDP 385 Query: 350 PWPRVSDNAKDLVRGML 400 W VS AKDL+ +L Sbjct: 386 VWKSVSRQAKDLISNLL 402
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 85.1 bits (209), Expect = 4e-17 Identities = 49/128 (38%), Positives = 70/128 (54%), Gaps = 4/128 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAP 193 V+ H V+HRDLKPEN L+ +K E + L DFG++ E + GS Y+AP Sbjct: 159 VEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAP 218 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQ--AIIRSVIDFKRDPWPRV 364 EVL ++ +G+ D+WS GVI Y LLCG PF AE+ +G + R + F W + Sbjct: 219 EVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNI 278 Query: 365 SDNAKDLV 388 S + K + Sbjct: 279 SIDVKRFI 286
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 84.7 bits (208), Expect = 5e-17 Identities = 46/133 (34%), Positives = 74/133 (55%), Gaps = 9/133 (6%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFA------NKKETAALKAIDFGLSVFFTPGER--FTEIVGSPYY 184 H + ++HRDLK EN + N + +K DFGL+V G+P Y Sbjct: 230 HNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIY 289 Query: 185 MAPEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 MAPEV+ +Y Q+ D+WS GV++Y+LL G PPF A +E+ + + I + + F+ W Sbjct: 290 MAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNS 349 Query: 362 VSDNAKDLVRGML 400 +SD AK +++ ++ Sbjct: 350 ISDCAKSVLKQLM 362
>MYLK2_MOUSE (Q8VCR8) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) (Fragment) Length = 240 Score = 84.3 bits (207), Expect = 6e-17 Identities = 49/127 (38%), Positives = 71/127 (55%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HK V+H DLKPEN L N +K IDFGL+ + P E+ G+P +++PEV+ Sbjct: 42 HKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVV-- 98 Query: 209 NYGQ---EVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAK 379 NY Q + D+WS GVI Y+LL G+ PF + + ++ + F + + VSD AK Sbjct: 99 NYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAK 158 Query: 380 DLVRGML 400 D V +L Sbjct: 159 DFVSNLL 165
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 84.3 bits (207), Expect = 6e-17 Identities = 48/142 (33%), Positives = 76/142 (53%), Gaps = 18/142 (12%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLF-ANKKETAA---------------LKAIDFGLSVFFTPGERFT 160 H+ ++HRD+KPEN L ++E + +K DFGL+ F + Sbjct: 320 HEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTN 379 Query: 161 EIVGSPYYMAPEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAET-EQGVAQAIIRSVI 334 + G+P Y+APEVL K+ Y +VD+WSAGVILY+ LCG PPF + + + I+++ Sbjct: 380 TLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKY 439 Query: 335 DFKRDPWPRVSDNAKDLVRGML 400 F W ++ D+ L+ +L Sbjct: 440 AFYSPYWDKIDDSVLHLISNLL 461
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 84.0 bits (206), Expect = 8e-17 Identities = 51/130 (39%), Positives = 69/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH V+HRDLK EN L N +K DFG FF GE GSP Y APE Sbjct: 130 VDYCHGRKVVHRDLKAENLLLDNNMN---IKIADFGFGNFFKTGELLATWCGSPPYAAPE 186 Query: 197 VLKRNY--GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V + G ++D+WS GV+LY+L+CG PF T + Q ++ R P+ +S+ Sbjct: 187 VFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF---RIPY-FMSE 242 Query: 371 NAKDLVRGML 400 + + L+R ML Sbjct: 243 DCEHLIRRML 252
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 84.0 bits (206), Expect = 8e-17 Identities = 49/130 (37%), Positives = 70/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH H ++HRDLK EN L + +K DFG F+ GE + GSP Y APE Sbjct: 137 VEYCHDHHIVHRDLKTENLLLDGNMD---IKLADFGFGNFYKSGEPLSTWCGSPPYAAPE 193 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V K G ++D+WS GV+LY+L+CG PF + Q ++ R P+ +S Sbjct: 194 VFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF---RIPF-FMSQ 249 Query: 371 NAKDLVRGML 400 + + L+R ML Sbjct: 250 DCESLIRRML 259
>MYLK2_RAT (P20689) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 609 Score = 83.6 bits (205), Expect = 1e-16 Identities = 48/127 (37%), Positives = 71/127 (55%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HK V+H DLKPEN L N +K IDFGL+ + P E+ G+P +++PEV+ Sbjct: 411 HKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVV-- 467 Query: 209 NYGQ---EVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAK 379 NY Q + D+WS GVI Y+LL G+ PF + + ++ + F + + VSD AK Sbjct: 468 NYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAK 527 Query: 380 DLVRGML 400 D V ++ Sbjct: 528 DFVSNLI 534
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 83.6 bits (205), Expect = 1e-16 Identities = 50/130 (38%), Positives = 69/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH ++HRDLK EN L N +K DFG FF GE GSP Y APE Sbjct: 130 VDYCHGRKIVHRDLKAENLLLDNNMN---IKIADFGFGNFFKSGELLATWCGSPPYAAPE 186 Query: 197 VLKRNY--GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V + G ++D+WS GV+LY+L+CG PF T + Q ++ R P+ +S+ Sbjct: 187 VFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF---RIPY-FMSE 242 Query: 371 NAKDLVRGML 400 + + L+R ML Sbjct: 243 DCEHLIRRML 252
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 83.6 bits (205), Expect = 1e-16 Identities = 43/125 (34%), Positives = 68/125 (54%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 H ++H DLKPEN L A+ + +K DFG + +VG+P Y+APEVL+ Sbjct: 691 HFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRS 750 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 + Y + +D+WS GVI+Y+ L G PF ++ + I + + +PW +S A DL Sbjct: 751 KGYNRSLDMWSVGVIIYVSLSGTFPF--NEDEDINDQIQNAAFMYPPNPWREISGEAIDL 808 Query: 386 VRGML 400 + +L Sbjct: 809 INNLL 813
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 83.6 bits (205), Expect = 1e-16 Identities = 50/132 (37%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + ++ +K IDFGL+ G F I G+P ++AP Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF +T+Q + DF+ + + Sbjct: 187 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNT 244 Query: 365 SDNAKDLVRGML 400 S AKD +R +L Sbjct: 245 STLAKDFIRRLL 256
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 83.6 bits (205), Expect = 1e-16 Identities = 43/125 (34%), Positives = 68/125 (54%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 H ++H DLKPEN L A+ + +K DFG + +VG+P Y+APEVL+ Sbjct: 690 HFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRS 749 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 + Y + +D+WS GVI+Y+ L G PF ++ + I + + +PW +S A DL Sbjct: 750 KGYNRSLDMWSVGVIVYVSLSGTFPF--NEDEDINDQIQNAAFMYPPNPWREISSEAIDL 807 Query: 386 VRGML 400 + +L Sbjct: 808 INNLL 812
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 83.2 bits (204), Expect = 1e-16 Identities = 43/125 (34%), Positives = 67/125 (53%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 H ++H DLKPEN L A+ +K DFG + +VG+P Y+APEVL+ Sbjct: 704 HFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRN 763 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 + Y + +D+WS GVI+Y+ L G PF ++ + I + + +PW +S A DL Sbjct: 764 KGYNRSLDMWSVGVIIYVSLSGTFPF--NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDL 821 Query: 386 VRGML 400 + +L Sbjct: 822 INNLL 826
>MYLK2_RABIT (P07313) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 607 Score = 83.2 bits (204), Expect = 1e-16 Identities = 48/127 (37%), Positives = 70/127 (55%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HK V+H DLKPEN L N +K IDFGL+ + P E+ G+P +++PEV+ Sbjct: 409 HKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVV-- 465 Query: 209 NYGQ---EVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAK 379 NY Q + D+WS GVI Y+LL G+ PF + + ++ F + + VSD AK Sbjct: 466 NYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAK 525 Query: 380 DLVRGML 400 D V ++ Sbjct: 526 DFVSNLI 532
>CHK1_USTMA (P0C198) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 662 Score = 83.2 bits (204), Expect = 1e-16 Identities = 51/132 (38%), Positives = 75/132 (56%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGL-SVFFTPGER--FTEIVGSPYYM 187 ++ H GV HRD+KPEN L + LK DFGL SV+ G+ T GS Y+ Sbjct: 181 LEYIHSQGVTHRDIKPENMLLDAEGN---LKIADFGLCSVYKYKGKERELTGACGSLPYI 237 Query: 188 APEVLKRNY-GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 APE+ + Y G+ VDVWS+GV+L+ +L G P+ T + + R+ F+ DPWPR+ Sbjct: 238 APEMNGKPYRGEPVDVWSSGVVLFAMLVGSTPWDEPTSRSPEYSAYRTGKLFEYDPWPRI 297 Query: 365 SDNAKDLVRGML 400 +A L++ M+ Sbjct: 298 PQDALSLLKKMM 309
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 83.2 bits (204), Expect = 1e-16 Identities = 46/125 (36%), Positives = 72/125 (57%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 H ++HRD+KPEN L +K DFG SV+ G++ + G+ Y++PE++K Sbjct: 215 HSKNILHRDIKPENILIGFNN---TIKLTDFGWSVYNEDGQKRKTLCGTIDYLSPELIKS 271 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 R Y +VDVW+ GV+ Y LL G PPF +T++ + I+R + F + VS A+DL Sbjct: 272 REYNNKVDVWALGVLTYELLVGSPPFEEDTKEMTYRRILRCDLKFPLN----VSPQARDL 327 Query: 386 VRGML 400 + +L Sbjct: 328 IVRLL 332
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 83.2 bits (204), Expect = 1e-16 Identities = 51/131 (38%), Positives = 71/131 (54%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLF-ANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V+ CH H ++HRDLK EN L AN +K DFG F+ GE + GSP Y AP Sbjct: 136 VEYCHSHHIVHRDLKTENLLLDANMN----IKLADFGFGNFYKSGEPLSTWCGSPPYAAP 191 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 EV K G +D+WS GV+LY+L+CG PF + Q ++ R P+ +S Sbjct: 192 EVFEGKEYEGPHLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRF---RIPY-FMS 247 Query: 368 DNAKDLVRGML 400 ++ + L+R ML Sbjct: 248 EDCETLIRRML 258
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 83.2 bits (204), Expect = 1e-16 Identities = 43/125 (34%), Positives = 67/125 (53%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 H ++H DLKPEN L A+ +K DFG + +VG+P Y+APEVL+ Sbjct: 698 HFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRN 757 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 + Y + +D+WS GVI+Y+ L G PF ++ + I + + +PW +S A DL Sbjct: 758 KGYNRSLDMWSVGVIIYVSLSGTFPF--NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDL 815 Query: 386 VRGML 400 + +L Sbjct: 816 INNLL 820
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 83.2 bits (204), Expect = 1e-16 Identities = 52/136 (38%), Positives = 73/136 (53%), Gaps = 10/136 (7%) Frame = +2 Query: 23 MCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVF--FTPGERFTEIVGSPYYMAPE 196 M + GV+HRDLKPEN L+A+ A +K IDFG + +P E + Y APE Sbjct: 520 MHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPE 579 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQG-------VAQAIIRSVIDFKRDP 352 +L ++ Y + D+WS GVILY++L G PF + QG + I + Sbjct: 580 LLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEA 639 Query: 353 WPRVSDNAKDLVRGML 400 W VS+ AK+LVRG+L Sbjct: 640 WQGVSEEAKELVRGLL 655 Score = 70.1 bits (170), Expect = 1e-12 Identities = 47/129 (36%), Positives = 71/129 (55%), Gaps = 5/129 (3%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE--RFTEIVGSPYYMAPEVL 202 HK G+++RDLK EN L ++ + DFGLS F E R G+ YMAPE++ Sbjct: 153 HKLGIIYRDLKLENVLLDSEGH---IVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEII 209 Query: 203 --KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP-RVSDN 373 K +G+ VD WS G++L+ LL G PF E E+ + R ++ P+P R+ Sbjct: 210 RSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCS-PPFPLRIGPV 268 Query: 374 AKDLVRGML 400 A+DL++ +L Sbjct: 269 AQDLLQRLL 277
>MYLK2_HUMAN (Q9H1R3) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 595 Score = 83.2 bits (204), Expect = 1e-16 Identities = 48/127 (37%), Positives = 70/127 (55%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 HK V+H DLKPEN L N +K IDFGL+ + P E+ G+P +++PEV+ Sbjct: 397 HKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVV-- 453 Query: 209 NYGQ---EVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAK 379 NY Q + D+WS GVI Y+LL G+ PF + + ++ F + + VSD AK Sbjct: 454 NYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAK 513 Query: 380 DLVRGML 400 D V ++ Sbjct: 514 DFVSNLI 520
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 82.8 bits (203), Expect = 2e-16 Identities = 50/129 (38%), Positives = 69/129 (53%), Gaps = 5/129 (3%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV----GSPYYMAPE 196 H+ ++HRDLKPEN LF + + LK +DFGLS E FT+ V GS Y++PE Sbjct: 165 HRSNIVHRDLKPENCLFLDNTVDSPLKIMDFGLSSV----EEFTDPVVGLFGSIDYVSPE 220 Query: 197 VLKRNY-GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 L + + D+W+ GVILYILL G PPF A++ + Q I+ F W Sbjct: 221 ALSQGQVTSKSDMWALGVILYILLSGYPPFIAQSNRQKQQMIMAGEFSFYEKTWKGFLCQ 280 Query: 374 AKDLVRGML 400 K L+ +L Sbjct: 281 PKQLISSLL 289
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 82.8 bits (203), Expect = 2e-16 Identities = 52/136 (38%), Positives = 73/136 (53%), Gaps = 10/136 (7%) Frame = +2 Query: 23 MCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVF--FTPGERFTEIVGSPYYMAPE 196 M + GV+HRDLKPEN L+A+ A +K IDFG + +PG + Y APE Sbjct: 520 MHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPE 579 Query: 197 VL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQG-------VAQAIIRSVIDFKRDP 352 +L ++ Y + D+WS GVILY++L G PF + QG + I + Sbjct: 580 LLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEA 639 Query: 353 WPRVSDNAKDLVRGML 400 W VS+ AK+LVRG+L Sbjct: 640 WQGVSEEAKELVRGLL 655 Score = 72.4 bits (176), Expect = 2e-13 Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 4/128 (3%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE--RFTEIVGSPYYMAPEVL 202 HK G+++RDLK EN L ++ + DFGLS F E R G+ YMAPE++ Sbjct: 153 HKLGIIYRDLKLENVLLDSEGH---IVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEII 209 Query: 203 --KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNA 376 K +G+ VD WS G++L+ LL G PF E E+ + R ++ PR+ A Sbjct: 210 RSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVA 269 Query: 377 KDLVRGML 400 +DL++ +L Sbjct: 270 QDLLQRLL 277
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 82.4 bits (202), Expect = 2e-16 Identities = 48/128 (37%), Positives = 67/128 (52%), Gaps = 4/128 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAP 193 V+ H ++HRDLKPEN L+ +K + + L DFG++ E + GS Y+AP Sbjct: 149 VKYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAP 208 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRS--VIDFKRDPWPRV 364 EVL ++ +G+ D+WS GVI Y LLCG F AE Q + F R W V Sbjct: 209 EVLTQDGHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSV 268 Query: 365 SDNAKDLV 388 S+ AK + Sbjct: 269 SNKAKQFI 276
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 82.4 bits (202), Expect = 2e-16 Identities = 46/91 (50%), Positives = 54/91 (59%), Gaps = 2/91 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V+ CH++ V+HRDLKPEN L +K +K DFGLS G GS Y APE Sbjct: 128 VEYCHRNKVVHRDLKPENLLLDSKYN---VKLADFGLSNVMHDGHFLKTSCGSLNYAAPE 184 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPF 283 V+ K G E+DVWS GVILY LLCG PF Sbjct: 185 VISGKLYAGPEIDVWSCGVILYALLCGAVPF 215
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 82.0 bits (201), Expect = 3e-16 Identities = 43/110 (39%), Positives = 65/110 (59%), Gaps = 2/110 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 +Q H + ++HRDLK EN + ++ E +K IDFGLS F ++ GS Y+ APE Sbjct: 236 LQYLHANNIVHRDLKIENIMISSSGE---IKIIDFGLSNIFDYRKQLHTFCGSLYFAAPE 292 Query: 197 VLKRN--YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDF 340 +LK G EVD+WS G++LY+L+CG PF E + + I + +D+ Sbjct: 293 LLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDY 342
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 82.0 bits (201), Expect = 3e-16 Identities = 51/132 (38%), Positives = 72/132 (54%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH G++HRDLKPEN L +K +K DFG++ T G+ GSP+Y APE Sbjct: 144 VSYCHALGIVHRDLKPENLLLDHKYN---IKIADFGMAALETEGKLLETSCGSPHYAAPE 200 Query: 197 VLK--RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVI--DFKRDPWPRV 364 ++ G DVWS GVIL+ LL G PF + E G + ++ V +F+ + Sbjct: 201 IVSGIPYQGFASDVWSCGVILFALLTGRLPF--DEEDGNIRTLLLKVQKGEFEMPSDDEI 258 Query: 365 SDNAKDLVRGML 400 S A+DL+R +L Sbjct: 259 SREAQDLIRKIL 270
>KAPC_ENCCU (Q8SRK8) Probable cAMP-dependent protein kinase catalytic subunit| (EC 2.7.11.11) Length = 322 Score = 82.0 bits (201), Expect = 3e-16 Identities = 48/129 (37%), Positives = 72/129 (55%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 ++ H G+++RDLKPEN L + T +K IDFG SV+ E I G+P YM+PE Sbjct: 120 LRFIHGRGILYRDLKPENILITS---TGHIKLIDFGFSVY--ESENIYMISGTPEYMSPE 174 Query: 197 VLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 L+ + G+ D W GV++Y +LCG PPF+ + + I+ S + F VS Sbjct: 175 KLRSEDDGRASDYWGLGVMIYEMLCGDPPFYDSSADAIYHKILESNVVFPH----YVSPV 230 Query: 374 AKDLVRGML 400 A+ L+ G+L Sbjct: 231 ARCLITGLL 239
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 81.6 bits (200), Expect = 4e-16 Identities = 49/132 (37%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAP 193 V H + H DLKPEN + ++ +K IDFGL+ G F I G+P ++AP Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186 Query: 194 EVLKRNY---GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 E++ NY G E D+WS GVI YILL G PF +T+Q + +F+ + + Sbjct: 187 EIV--NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNT 244 Query: 365 SDNAKDLVRGML 400 S AKD +R +L Sbjct: 245 SALAKDFIRRLL 256
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)| Length = 878 Score = 81.6 bits (200), Expect = 4e-16 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEV-LK 205 H ++H DLKPEN L A+ +K DFG + +VG+P Y+APEV L Sbjct: 666 HFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN 725 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 + Y + +D+WS GVI+Y+ L G PF ++ + I + + PW +S A DL Sbjct: 726 QGYNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISAGAIDL 783 Query: 386 VRGML 400 + +L Sbjct: 784 INNLL 788
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 81.6 bits (200), Expect = 4e-16 Identities = 50/126 (39%), Positives = 71/126 (56%), Gaps = 1/126 (0%) Frame = +2 Query: 26 CHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 CH V+HRD+KPEN L + E LK DFG SV P R T + G+ Y+ PE+++ Sbjct: 238 CHSKRVIHRDIKPENLLLGSNGE---LKIADFGWSVH-APSSRRTTMCGTLDYLPPEMIE 293 Query: 206 -RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKD 382 R + ++VD+WS GV+ Y L G+PPF A T Q + I R F V++ A+D Sbjct: 294 GRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP----DFVTEGARD 349 Query: 383 LVRGML 400 L+ +L Sbjct: 350 LISRLL 355
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 81.3 bits (199), Expect = 5e-16 Identities = 44/87 (50%), Positives = 54/87 (62%), Gaps = 2/87 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE-RFTEIVGSPYYMAPEVLK 205 H+ G++HRDLK NF + E LK DFGL+ P E R I G+P Y+APEVL Sbjct: 146 HQRGILHRDLKLGNFFITDNME---LKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 202 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPF 283 R +G E DVWS G ++Y LLCG PPF Sbjct: 203 RQGHGPEADVWSLGCVMYTLLCGSPPF 229
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 81.3 bits (199), Expect = 5e-16 Identities = 50/126 (39%), Positives = 70/126 (55%), Gaps = 1/126 (0%) Frame = +2 Query: 26 CHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 CH V+HRD+KPEN L + E LK DFG SV P R T + G+ Y PE+++ Sbjct: 240 CHSKRVIHRDIKPENLLLGSNGE---LKIADFGWSVH-APSSRRTTLCGTLDYQPPEMIE 295 Query: 206 -RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKD 382 R + ++VD+WS GV+ Y L G+PPF A T Q + I R F V++ A+D Sbjct: 296 GRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP----DFVTEGARD 351 Query: 383 LVRGML 400 L+ +L Sbjct: 352 LISRLL 357
>PLK3_MOUSE (Q60806) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) Length = 631 Score = 81.3 bits (199), Expect = 5e-16 Identities = 44/87 (50%), Positives = 54/87 (62%), Gaps = 2/87 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE-RFTEIVGSPYYMAPEVLK 205 H+ G++HRDLK NF + E LK DFGL+ P E R I G+P Y+APEVL Sbjct: 178 HQRGILHRDLKLGNFFITDNME---LKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 234 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPF 283 R +G E DVWS G ++Y LLCG PPF Sbjct: 235 RQGHGPEADVWSLGCVMYTLLCGSPPF 261
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 80.9 bits (198), Expect = 7e-16 Identities = 42/106 (39%), Positives = 64/106 (60%), Gaps = 2/106 (1%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 H + ++HRDLK EN + ++ E +K IDFGLS + ++ GS Y+ APE+LK Sbjct: 261 HANNIVHRDLKIENIMISDSSE---IKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKA 317 Query: 209 N--YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDF 340 N G EVDVWS GV+L++L+CG PF E + + I + +++ Sbjct: 318 NPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEY 363
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 80.9 bits (198), Expect = 7e-16 Identities = 44/87 (50%), Positives = 53/87 (60%), Gaps = 2/87 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE-RFTEIVGSPYYMAPEVLK 205 H+ G++HRDLK NF E LK DFGL+ P E R I G+P Y+APEVL Sbjct: 177 HQRGILHRDLKLGNFFITENME---LKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 233 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPF 283 R +G E DVWS G ++Y LLCG PPF Sbjct: 234 RQGHGPEADVWSLGCVMYTLLCGSPPF 260
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 80.5 bits (197), Expect = 9e-16 Identities = 47/126 (37%), Positives = 69/126 (54%), Gaps = 2/126 (1%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKR 208 H++ V+HRDLK EN L + +T +K IDFGLS + R GS Y+ APE+L Sbjct: 258 HQNSVVHRDLKIENILIS---KTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNA 314 Query: 209 N--YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKD 382 G EVDVWS G++LY+L+CG PF + + I + +++ +S + K Sbjct: 315 QPYIGPEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIKKGTVEYP----SYLSSDCKG 370 Query: 383 LVRGML 400 L+ ML Sbjct: 371 LLSRML 376
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 80.5 bits (197), Expect = 9e-16 Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH ++HRDLK EN L N +K DF FF GE GSP Y APE Sbjct: 130 VDYCHGRKIVHRDLKAENLLLDNNMN---IKIADFSFGNFFKSGELLATWRGSPPYAAPE 186 Query: 197 VLKRNY--GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V + G ++D+WS GV+LY+L+CG PF T + Q ++ R P+ +S+ Sbjct: 187 VFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRF---RIPY-FMSE 242 Query: 371 NAKDLVRGML 400 + + L+R ML Sbjct: 243 DCEHLIRRML 252
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 80.5 bits (197), Expect = 9e-16 Identities = 50/126 (39%), Positives = 70/126 (55%), Gaps = 1/126 (0%) Frame = +2 Query: 26 CHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK 205 CH V+HRD+KPEN L + E LK DFG SV P R T + G+ Y+ PE+++ Sbjct: 247 CHSKRVIHRDIKPENLLLGSAGE---LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIE 302 Query: 206 -RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKD 382 R + ++VD+WS GV+ Y L G PPF A T Q + I R F V++ A+D Sbjct: 303 GRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFP----DFVTEGARD 358 Query: 383 LVRGML 400 L+ +L Sbjct: 359 LISRLL 364
>KRAC_DICDI (P54644) RAC-family serine/threonine-protein kinase homolog (EC| 2.7.11.1) Length = 444 Score = 80.1 bits (196), Expect = 1e-15 Identities = 48/127 (37%), Positives = 72/127 (56%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSV--FFTPGERFTEIVGSPYYMAPEVL 202 H GV++RDLKPEN L N+ DFGL TP ++ G+P Y+APEVL Sbjct: 235 HLSGVIYRDLKPENLLLTNEGHICMT---DFGLCKEGLLTPTDKTGTFCGTPEYLAPEVL 291 Query: 203 KRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAK 379 + N YG++VD WS G +LY +L G+PPF+ + Q + + I+ + F +S +A+ Sbjct: 292 QGNGYGKQVDWWSFGSLLYEMLTGLPPFYNQDVQEMYRKIMMEKLSFPH----FISPDAR 347 Query: 380 DLVRGML 400 L+ +L Sbjct: 348 SLLEQLL 354
>ST17B_MOUSE (Q8BG48) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 80.1 bits (196), Expect = 1e-15 Identities = 44/133 (33%), Positives = 70/133 (52%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H++ ++H DLKP+N L ++ +K +DFG+S EI+G+P Y+A Sbjct: 144 EGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLA 203 Query: 191 PEVLKRNYG---QEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PE+L NY D+W+ G+I Y+LL PF E Q I + +D+ + + Sbjct: 204 PEIL--NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSS 261 Query: 362 VSDNAKDLVRGML 400 VS A D ++ +L Sbjct: 262 VSQLATDFIQSLL 274
>ST17B_RAT (Q91XS8) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 371 Score = 80.1 bits (196), Expect = 1e-15 Identities = 44/133 (33%), Positives = 70/133 (52%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H++ ++H DLKP+N L ++ +K +DFG+S EI+G+P Y+A Sbjct: 144 EGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLA 203 Query: 191 PEVLKRNYG---QEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PE+L NY D+W+ G+I Y+LL PF E Q I + +D+ + + Sbjct: 204 PEIL--NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSS 261 Query: 362 VSDNAKDLVRGML 400 VS A D ++ +L Sbjct: 262 VSQLATDFIQSLL 274
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 80.1 bits (196), Expect = 1e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 170 VQYCHQKYIVHRDLKAENLLLDGDMN---IKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 226 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 271
>MEK1_YEAST (P24719) Meiosis-specific serine/threonine-protein kinase MEK1 (EC| 2.7.11.1) Length = 497 Score = 80.1 bits (196), Expect = 1e-15 Identities = 47/150 (31%), Positives = 73/150 (48%), Gaps = 20/150 (13%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPG-ERFTEIVGSPYYM 187 + + H ++HRDLK +N L + + DFG++ ER +VG+P Y Sbjct: 276 QALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYC 335 Query: 188 APEV------------------LKRNYGQEVDVWSAGVILYILLCGVPPFWAE-TEQGVA 310 APEV +R Y + D+WS GVI +I+L G+ PF+ + +E+ + Sbjct: 336 APEVGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSII 395 Query: 311 QAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 Q ++FK W VSDNAK V+ +L Sbjct: 396 QNAKIGKLNFKLKQWDIVSDNAKSFVKDLL 425
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 79.7 bits (195), Expect = 2e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 166 VQYCHQKRIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGSKLDTFCGSPPYAAPE 222 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 223 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 267
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 79.7 bits (195), Expect = 2e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 166 VQYCHQKRIVHRDLKAENLLLDADMN---IKITDFGFSNEFTVGSKLDTFCGSPPYAAPE 222 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 223 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 267
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 79.3 bits (194), Expect = 2e-15 Identities = 43/131 (32%), Positives = 74/131 (56%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + + HK ++HRD+KPEN L +K DFG S+ G + + G+ Y++ Sbjct: 209 DALHYMHKKRIIHRDVKPENVLIGFDN---VVKLADFGWSILNPEGSKRKTLCGTIDYLS 265 Query: 191 PEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE++ R Y ++VDVW+ GV+ Y L+ GVPPF +++ + I++ ++F +S Sbjct: 266 PEMITPREYDEQVDVWALGVLAYELVVGVPPFEENSKELTYKRILKCDLNFPES----IS 321 Query: 368 DNAKDLVRGML 400 +AKDL+ +L Sbjct: 322 KDAKDLISKLL 332
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 79.3 bits (194), Expect = 2e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 170 VQYCHQKCIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 226 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 271
>LIN2_CAEEL (P54936) Protein lin-2 (Abnormal cell lineage protein 2)| Length = 961 Score = 79.3 bits (194), Expect = 2e-15 Identities = 44/133 (33%), Positives = 78/133 (58%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTP--GERFTEIVGSPYY 184 + + CH ++HRD++P N + A+K +A LK FG++ + G VG P + Sbjct: 132 DALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIGGSMACGRVGVPQF 191 Query: 185 MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 MAPE+++++ D+WS+GV+L++LL G PF T + + I+++ +D P Sbjct: 192 MAPEIVRKDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSD-IYERIMQTDVDVD-GYMPN 249 Query: 362 VSDNAKDLVRGML 400 +S++A++LVR ML Sbjct: 250 ISESARNLVRRML 262
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 79.3 bits (194), Expect = 2e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 170 VQYCHQKCIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 226 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 271
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 79.0 bits (193), Expect = 3e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 189 VQYCHQKRIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGGKLDTFCGSPPYAAPE 245 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 246 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 290
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 79.0 bits (193), Expect = 3e-15 Identities = 44/105 (41%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+ ++HRDLK EN L + A +K DFG S FT G + GSP Y APE Sbjct: 169 VHYCHQKNIVHRDLKAENLLLDAE---ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPE 225 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVD+WS GVILY L+ G PF + + + ++R Sbjct: 226 LFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR 270
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 79.0 bits (193), Expect = 3e-15 Identities = 44/105 (41%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CH+ ++HRDLK EN L + A +K DFG S FT G + GSP Y APE Sbjct: 169 VHYCHQKNIVHRDLKAENLLLDAE---ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPE 225 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVD+WS GVILY L+ G PF + + + ++R Sbjct: 226 LFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR 270
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 78.6 bits (192), Expect = 3e-15 Identities = 44/94 (46%), Positives = 55/94 (58%), Gaps = 5/94 (5%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVF---FTPGERFTEIVGSPYYM 187 V CH GV HRDLKPEN L E LK DFGLS P + G+P Y+ Sbjct: 133 VGYCHARGVYHRDLKPENLLI---DENGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAYV 189 Query: 188 APEVL-KRNY-GQEVDVWSAGVILYILLCGVPPF 283 APE+L K+ Y G +VDVWS G++L++L+ G PF Sbjct: 190 APEILSKKGYEGAKVDVWSCGIVLFVLVAGYLPF 223
>ST17B_HUMAN (O94768) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 78.6 bits (192), Expect = 3e-15 Identities = 44/133 (33%), Positives = 70/133 (52%), Gaps = 3/133 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V H++ ++H DLKP+N L ++ +K +DFG+S EI+G+P Y+A Sbjct: 144 EGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLA 203 Query: 191 PEVLKRNYG---QEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 PE+L NY D+W+ G+I Y+LL PF E Q I + +D+ + + Sbjct: 204 PEIL--NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSS 261 Query: 362 VSDNAKDLVRGML 400 VS A D ++ +L Sbjct: 262 VSQLATDFIQSLL 274
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 78.6 bits (192), Expect = 3e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 163 VQYCHQKFIVHRDLKAENLLLDADMN---IKIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 264
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 78.6 bits (192), Expect = 3e-15 Identities = 47/126 (37%), Positives = 68/126 (53%), Gaps = 2/126 (1%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGL-SVFFTPGERFTEIVGSPYYMAPEVLK 205 H G+++RDLK EN L + +K DFGL T G G+P Y+APEVL Sbjct: 381 HSQGIIYRDLKLENLLL---DKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLD 437 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKD 382 N YGQ VD W GV++Y ++CG PF+ + I+ + F R+ ++D AK+ Sbjct: 438 DNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRN----ITDEAKN 493 Query: 383 LVRGML 400 L+ G+L Sbjct: 494 LLAGLL 499
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 78.6 bits (192), Expect = 3e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 163 VQYCHQKFIVHRDLKAENLLLDADMN---IKIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 264
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 78.2 bits (191), Expect = 4e-15 Identities = 52/133 (39%), Positives = 74/133 (55%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSV---FFTPGERFTEIVGSPYYM 187 V+ H+ GV+HRDLK EN L E +K IDFGLS + F+ GSP Y Sbjct: 174 VEHLHRAGVVHRDLKIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP-R 361 APE+L R YG ++DVWS GV +Y +L G PF E +A+ + ++D + +P P + Sbjct: 231 APELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFS--LRALYQKMVDKEMNPLPTQ 288 Query: 362 VSDNAKDLVRGML 400 +S A +R +L Sbjct: 289 LSTGAISFLRSLL 301
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 78.2 bits (191), Expect = 4e-15 Identities = 52/133 (39%), Positives = 74/133 (55%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSV---FFTPGERFTEIVGSPYYM 187 V+ H+ GV+HRDLK EN L E +K IDFGLS + F+ GSP Y Sbjct: 174 VEHLHRAGVVHRDLKIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP-R 361 APE+L R YG ++DVWS GV +Y +L G PF E +A+ + ++D +P P + Sbjct: 231 APELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFS--LRALYQKMVDKAMNPLPTQ 288 Query: 362 VSDNAKDLVRGML 400 +S A + +R +L Sbjct: 289 LSTGAVNFLRSLL 301
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 78.2 bits (191), Expect = 4e-15 Identities = 52/133 (39%), Positives = 74/133 (55%), Gaps = 5/133 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSV---FFTPGERFTEIVGSPYYM 187 V+ H+ GV+HRDLK EN L E +K IDFGLS + F+ GSP Y Sbjct: 174 VEHLHRAGVVHRDLKIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230 Query: 188 APEVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP-R 361 APE+L R YG ++DVWS GV +Y +L G PF E +A+ + ++D + +P P + Sbjct: 231 APELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFS--LRALYQKMVDKEMNPLPTQ 288 Query: 362 VSDNAKDLVRGML 400 +S A +R +L Sbjct: 289 LSTGAISFLRSLL 301
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 78.2 bits (191), Expect = 4e-15 Identities = 39/109 (35%), Positives = 60/109 (55%), Gaps = 2/109 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + + CHKH +HRD+KPEN L + +K DFG + PG+ +T+ V + +Y A Sbjct: 112 QALNFCHKHNCIHRDVKPENILITKQ---GMIKICDFGFARILIPGDAYTDYVATRWYRA 168 Query: 191 PEVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV 331 PE+L YG VDVW+ G + LL G P + +++ IIR++ Sbjct: 169 PELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTL 217
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 78.2 bits (191), Expect = 4e-15 Identities = 45/105 (42%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 VQ CH+ ++HRDLK EN L +K DFG S FT G + GSP Y APE Sbjct: 163 VQYCHQKFIVHRDLKAENLLLDADMN---IKIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219 Query: 197 VL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIR 325 + K+ G EVDVWS GVILY L+ G PF + + + + ++R Sbjct: 220 LFQGKKIDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 264
>CHK2_CAEEL (Q9U1Y5) Serine/threonine-protein kinase chk-2 (EC 2.7.11.1)| (Ce-cds-1) (Ce-chk-2) Length = 476 Score = 77.8 bits (190), Expect = 6e-15 Identities = 43/134 (32%), Positives = 71/134 (52%), Gaps = 4/134 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + + H G+ HRD+KPEN L ++K E LK DFG++ R G+P Y A Sbjct: 287 DAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAK--NSVNRMKTRCGTPSYNA 344 Query: 191 PEVLKR---NYGQEVDVWSAGVILYILLCGVPPFWAE-TEQGVAQAIIRSVIDFKRDPWP 358 PE++ Y +VD+WS G +L+I G PPF E T+ + + ++ + F W Sbjct: 345 PEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQ-WR 403 Query: 359 RVSDNAKDLVRGML 400 R++ +++++ ML Sbjct: 404 RITVETQNMIKWML 417
>PRKX_MOUSE (Q922R0) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (PKA-related protein kinase) Length = 355 Score = 77.8 bits (190), Expect = 6e-15 Identities = 42/129 (32%), Positives = 75/129 (58%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 ++ H +++RDLKPEN L + +K DFG + +R + G+P Y+APE Sbjct: 157 IEYLHSKEIVYRDLKPENILLDREGH---IKLTDFGFAKKLV--DRTWTLCGTPEYLAPE 211 Query: 197 VLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 V++ + +G+ VD W+ G++++ +L G PPF+ + G+ Q I+ IDF R ++ Sbjct: 212 VIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPR----QLDFT 267 Query: 374 AKDLVRGML 400 +KDL++ +L Sbjct: 268 SKDLIKKLL 276
>CDC2_CHERU (P93101) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 77.4 bits (189), Expect = 8e-15 Identities = 47/120 (39%), Positives = 65/120 (54%), Gaps = 3/120 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 + CH H V+HRDLKP+N L ++T ALK DFGL+ F P FT V + +Y AP Sbjct: 115 IAYCHSHRVLHRDLKPQNLLI--DRQTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAP 172 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 E+L R+Y VDVWS G I ++ P F ++E I R++ + WP V+ Sbjct: 173 EILLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRTLGTPNEETWPGVT 232
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 77.4 bits (189), Expect = 8e-15 Identities = 38/102 (37%), Positives = 62/102 (60%), Gaps = 7/102 (6%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFL--FANKKETAA----LKAIDFGLSVFFTPGERFTEIVGSP 178 +++ H G++HRDLKP+N L +AN+++++ +K DFG + + + GSP Sbjct: 119 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSP 178 Query: 179 YYMAPEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQ 301 YMAPEV+ ++Y + D+WS G ++Y L G PPF A + Q Sbjct: 179 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQ 220
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 77.4 bits (189), Expect = 8e-15 Identities = 53/132 (40%), Positives = 68/132 (51%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 ++ H V+HRDLK N F + LK DFGL+ V ER I G+P Y+AP Sbjct: 192 IKYMHSRRVIHRDLKLGNIFFDSNYN---LKIGDFGLAAVLANESERKYTICGTPNYIAP 248 Query: 194 EVLKRNYGQ---EVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 EVL + EVD+WS GV+LY LL G PPF A + + I F RD + Sbjct: 249 EVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRD--KPI 306 Query: 365 SDNAKDLVRGML 400 SD K L+R +L Sbjct: 307 SDEGKILIRDIL 318
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 77.4 bits (189), Expect = 8e-15 Identities = 44/108 (40%), Positives = 56/108 (51%), Gaps = 14/108 (12%) Frame = +2 Query: 14 VVQMCH------KHGVMHRDLKPENFLFANKKETA-------ALKAIDFGLSVFFTPGER 154 VVQ+ H K G++HRDLKP+N L N T +K DFG + F G Sbjct: 115 VVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVM 174 Query: 155 FTEIVGSPYYMAPEV-LKRNYGQEVDVWSAGVILYILLCGVPPFWAET 295 + GSP YMAPEV + Y + D+WS G IL+ L G PF A+T Sbjct: 175 AATLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQT 222
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (Protein kinase PKX1) Length = 358 Score = 77.4 bits (189), Expect = 8e-15 Identities = 42/129 (32%), Positives = 73/129 (56%), Gaps = 1/129 (0%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 ++ H +++RDLKPEN L +K DFG + +R + G+P Y+APE Sbjct: 160 IEYLHSKEIVYRDLKPENILL---DRDGHIKLTDFGFAKKLV--DRTWTLCGTPEYLAPE 214 Query: 197 VLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDN 373 V++ + +G+ VD W+ G++++ +L G PPF+ + G+ Q I+ IDF R + + Sbjct: 215 VIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPR----HLDFH 270 Query: 374 AKDLVRGML 400 KDL++ +L Sbjct: 271 VKDLIKKLL 279
>NEK2_HUMAN (P51955) Serine/threonine-protein kinase Nek2 (EC 2.7.11.1)| (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) Length = 445 Score = 77.0 bits (188), Expect = 1e-14 Identities = 49/132 (37%), Positives = 73/132 (55%), Gaps = 7/132 (5%) Frame = +2 Query: 26 CHK-----HGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTE-IVGSPYYM 187 CH+ H V+HRDLKP N K+ +K DFGL+ F + VG+PYYM Sbjct: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQN---VKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 188 APEVLKR-NYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PE + R +Y ++ D+WS G +LY L +PPF A +++ +A I F+R P+ R Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG--KFRRIPY-RY 240 Query: 365 SDNAKDLVRGML 400 SD +++ ML Sbjct: 241 SDELNEIITRML 252
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 77.0 bits (188), Expect = 1e-14 Identities = 39/92 (42%), Positives = 55/92 (59%), Gaps = 3/92 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFT-PGERFTEIVGSPYYM 187 + V CHKH +HRD+KPEN L + +A+K DFG + T PG+ +T+ V + +Y Sbjct: 112 QAVNFCHKHNCIHRDVKPENILITKQ---SAIKLCDFGFARLLTGPGDYYTDYVATRWYR 168 Query: 188 APEVL--KRNYGQEVDVWSAGVILYILLCGVP 277 +PE+L YG VDVW+ G + LL GVP Sbjct: 169 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVP 200
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 76.6 bits (187), Expect = 1e-14 Identities = 49/118 (41%), Positives = 61/118 (51%), Gaps = 3/118 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPG-ERFTEIVGSPYYM 187 + V CH GV HRDLKPEN L LK DFGLS G E G+P Y+ Sbjct: 120 DAVAHCHCKGVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYV 176 Query: 188 APEVLK-RNY-GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPW 355 APEVL + Y G D+WS GVIL+++L G PF G+ + I + +F PW Sbjct: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPW 232
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 76.6 bits (187), Expect = 1e-14 Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 5/135 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFT---PGERFTEIVGSPY 181 E + H GV HRDLKPEN L LK DFG + F+ VGSP Sbjct: 123 EGISFMHSKGVAHRDLKPENILL---DYNGNLKISDFGFASLFSYKGKSRLLNSPVGSPP 179 Query: 182 YMAPEVLKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAII--RSVIDFKRDPW 355 Y APE+ ++ G +VDVWS G+IL+ LL G P W E ++ + PW Sbjct: 180 YAAPEITQQYDGSKVDVWSCGIILFALLLGNTP-WDEAISNTGDYLLYKKQCERPSYHPW 238 Query: 356 PRVSDNAKDLVRGML 400 +S A ++ GML Sbjct: 239 NLLSPGAYSIITGML 253
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 76.6 bits (187), Expect = 1e-14 Identities = 45/94 (47%), Positives = 52/94 (55%), Gaps = 5/94 (5%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGER---FTEIVGSPYYM 187 V CH GV HRDLKPEN L E LK DFGLS + G+P Y+ Sbjct: 122 VDFCHSRGVCHRDLKPENLLL---DEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYV 178 Query: 188 APEVLKRN--YGQEVDVWSAGVILYILLCGVPPF 283 APEV+ RN G + DVWS GVIL++LL G PF Sbjct: 179 APEVISRNGYDGFKADVWSCGVILFVLLAGYLPF 212
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 76.6 bits (187), Expect = 1e-14 Identities = 38/102 (37%), Positives = 61/102 (59%), Gaps = 7/102 (6%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFL--FANKKETAA----LKAIDFGLSVFFTPGERFTEIVGSP 178 +++ H G++HRDLKP+N L +AN++++ +K DFG + + + GSP Sbjct: 119 MRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSP 178 Query: 179 YYMAPEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQ 301 YMAPEV+ ++Y + D+WS G ++Y L G PPF A + Q Sbjct: 179 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQ 220
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 76.3 bits (186), Expect = 2e-14 Identities = 45/124 (36%), Positives = 68/124 (54%), Gaps = 3/124 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 V CH++ ++HRDLKP+N L N+ + LK DFGL+ F P F+ V + +Y AP Sbjct: 121 VAFCHENRILHRDLKPQNLLINNRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 +VL RNY +D+WS G IL ++ G P F ++ + I ++ WP+V+ Sbjct: 178 DVLMGSRNYCTSIDIWSCGCILAEMIMGKPLFPGSNDEEQLKLIFDTMGTPVEQTWPQVT 237 Query: 368 DNAK 379 AK Sbjct: 238 QLAK 241
>MKNK1_XENTR (Q66JF3) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 417 Score = 76.3 bits (186), Expect = 2e-14 Identities = 52/153 (33%), Positives = 70/153 (45%), Gaps = 29/153 (18%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV--------GSPYY 184 H G+ HRDLKPEN L K + + +K DF L T I GS Y Sbjct: 150 HTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNSACTPITTPELTTPCGSAEY 209 Query: 185 MAPEVLK------RNYGQEVDVWSAGVILYILLCGVPPF---------WAETE------Q 301 MAPEV++ Y + D+WS GVILYI+L G PPF W E Sbjct: 210 MAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGADCGWDRGEMCRVCQN 269 Query: 302 GVAQAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 + ++I +F W +S++AKDL+ +L Sbjct: 270 KLFESIQEGKYEFPEKDWSHISNSAKDLISKLL 302
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 76.3 bits (186), Expect = 2e-14 Identities = 43/129 (33%), Positives = 65/129 (50%), Gaps = 2/129 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 + CH H + HRDLKPEN L K ++ DFG++ GSP+Y PE Sbjct: 129 LDFCHSHSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETSCGSPHYACPE 185 Query: 197 VLK--RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V++ + G++ DVWS GVIL+ LL G PF + + + + + R V + Sbjct: 186 VIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPH----FIPP 241 Query: 371 NAKDLVRGM 397 + + L+RGM Sbjct: 242 DCQSLLRGM 250
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 76.3 bits (186), Expect = 2e-14 Identities = 44/117 (37%), Positives = 62/117 (52%), Gaps = 3/117 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 V+ CH+ V+HRDLKP N L + +KE LK DFGL F P ++FT+ V + +Y +P Sbjct: 115 VRFCHERNVLHRDLKPPNLLISREKE---LKLADFGLGRAFGIPVKKFTQEVVTLWYRSP 171 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP 358 +VL YG VD+WS G I + G P F + + I + + R WP Sbjct: 172 DVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFTGKNDADQLLRIFQFLGTPNRQVWP 228
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 76.3 bits (186), Expect = 2e-14 Identities = 44/119 (36%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 + CH H ++HRDLKP+N L + LK DFGL+ F P +T V + +Y AP Sbjct: 113 ISYCHDHRILHRDLKPQNLLINRE---GVLKLADFGLARAFAIPVRSYTHEVVTLWYRAP 169 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +VL + Y VD+WS G I ++ GVP F +EQ + I + + D WP+V Sbjct: 170 DVLMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGTPSVDSWPQV 228
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 76.3 bits (186), Expect = 2e-14 Identities = 44/119 (36%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 + CH H ++HRDLKP+N L + LK DFGL+ F P +T V + +Y AP Sbjct: 113 ISYCHDHRILHRDLKPQNLLINRE---GVLKLADFGLARAFAIPVRSYTHEVVTLWYRAP 169 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +VL + Y VD+WS G I ++ GVP F +EQ + I + + D WP+V Sbjct: 170 DVLMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGTPNVDSWPQV 228
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 75.9 bits (185), Expect = 2e-14 Identities = 49/130 (37%), Positives = 70/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CHK+GV+HRDLK EN L + +K DFGLS + + GSP Y +PE Sbjct: 167 VHYCHKNGVVHRDLKLENILL---DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPE 223 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 ++ R Y G EVD W+ GV+LY L+ G PF + + + I S +++ P Sbjct: 224 IVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQI--SSGEYRE---PTQPS 278 Query: 371 NAKDLVRGML 400 +A+ L+R ML Sbjct: 279 DARGLIRWML 288
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 75.9 bits (185), Expect = 2e-14 Identities = 52/137 (37%), Positives = 70/137 (51%), Gaps = 9/137 (6%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYY--- 184 VQ H V HRDL N LFA K + ++L+ +DFG F ++ +P Y Sbjct: 560 VQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFG---FAKQSRAENGMLMTPCYTAQ 616 Query: 185 -MAPEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWA---ETEQGVAQAIIRSVIDFKRD 349 +APEVL K+ Y + DVWS GV+L+ +L G PF +T + Q + I Sbjct: 617 FVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHP 676 Query: 350 PWPRVSDNAKDLVRGML 400 W +SD AKDLVR ML Sbjct: 677 VWDTISDEAKDLVRKML 693 Score = 60.5 bits (145), Expect = 1e-09 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 2/102 (1%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAPEVL- 202 H G+++RDLKPEN L +K DFGLS E+ T G+ YMAPEV+ Sbjct: 221 HSLGIVYRDLKPENILL---DADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVIN 277 Query: 203 KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRS 328 +R + D WS GV+++ +L G PF I+++ Sbjct: 278 RRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKA 319
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 75.9 bits (185), Expect = 2e-14 Identities = 41/131 (31%), Positives = 71/131 (54%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + + H+ ++HRD+KPEN + +K DFG SV G + + G+ Y++ Sbjct: 218 DALDYMHERNILHRDIKPENIIIGFNN---TIKLTDFGWSVITPKGSKRKTLCGTVDYLS 274 Query: 191 PEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE+++ R Y ++VDVW+ GV+ Y LL G PPF E+++ + I++ + F V Sbjct: 275 PELIRSREYNEKVDVWALGVLTYELLVGSPPFEEESKELTYKRILKRNLIFP----DHVD 330 Query: 368 DNAKDLVRGML 400 A+ L+ +L Sbjct: 331 TEARHLISRLL 341
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 75.9 bits (185), Expect = 2e-14 Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAPEVLK 205 H H ++HRD+KP+N L A + +K DFG + T T I G+P YM+PE+++ Sbjct: 117 HSHRILHRDMKPQNILLA---KGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVE 173 Query: 206 -RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP-RVSDNAK 379 R Y D+WS G ILY L G PPF+A + + I++ + WP +S K Sbjct: 174 ERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV-----RWPSTISPCFK 228 Query: 380 DLVRGML 400 + ++G+L Sbjct: 229 NFLQGLL 235
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 75.9 bits (185), Expect = 2e-14 Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 3/127 (2%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAPEVLK 205 H H ++HRD+KP+N L A + +K DFG + T T I G+P YM+PE+++ Sbjct: 117 HSHRILHRDMKPQNILLA---KGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVE 173 Query: 206 -RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWP-RVSDNAK 379 R Y D+WS G ILY L G PPF+A + + I++ + WP +S K Sbjct: 174 ERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV-----RWPSTISPCFK 228 Query: 380 DLVRGML 400 + ++G+L Sbjct: 229 NFLQGLL 235
>OBSCN_HUMAN (Q5VST9) Obscurin (Obscurin-myosin light chain kinase)| (Obscurin-MLCK) (Obscurin-RhoGEF) Length = 7968 Score = 75.9 bits (185), Expect = 2e-14 Identities = 40/131 (30%), Positives = 68/131 (51%), Gaps = 1/131 (0%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E + H HGV+H D+KP N L + +K DFG + TP E GSP +++ Sbjct: 6573 EGLHYLHSHGVLHLDIKPSNILMVHPARED-IKICDFGFAQNITPAELQFSQYGSPEFVS 6631 Query: 191 PEVLKRNYGQEV-DVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 PE++++N E D+W+ GVI Y+ L PF E+++ ++ + + +S Sbjct: 6632 PEIIQQNPVSEASDIWAMGVISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLS 6691 Query: 368 DNAKDLVRGML 400 ++AKD ++ L Sbjct: 6692 EDAKDFIKATL 6702 Score = 42.4 bits (98), Expect = 3e-04 Identities = 28/115 (24%), Positives = 56/115 (48%), Gaps = 6/115 (5%) Frame = +2 Query: 20 QMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFT-----PGERFTEIVGSPYY 184 Q H ++H DL+ EN + E LK +D G + + P ++F + + + Sbjct: 7780 QYLHNQHILHLDLRSENMIIT---EYNLLKVVDLGNAQSLSQEKVLPSDKFKDYLET--- 7833 Query: 185 MAPEVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKR 346 MAPE+L+ + + D+W+ GV +I+L P +E + + + + + ++ R Sbjct: 7834 MAPELLEGQGAVPQTDIWAIGVTAFIMLSAEYPVSSEGARDLQRGLRKGLVRLSR 7888
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 75.9 bits (185), Expect = 2e-14 Identities = 46/132 (34%), Positives = 73/132 (55%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE---RFTEIVGSPYYM 187 ++ H G++HRDLKPEN L E ++ DFG + +P R VG+ Y+ Sbjct: 196 LEYLHGKGIIHRDLKPENILL---NEDMHIQITDFGTAKVLSPDSKQARANSFVGTAQYV 252 Query: 188 APEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PE+L +++ + D+W+ G I+Y L+ G+PPF A E + Q II+ DF +P+ Sbjct: 253 SPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK- 311 Query: 365 SDNAKDLVRGML 400 A+DLV +L Sbjct: 312 ---ARDLVEKLL 320
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 75.5 bits (184), Expect = 3e-14 Identities = 49/130 (37%), Positives = 70/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 V CHK+GV+HRDLK EN L + +K DFGLS + + GSP Y +PE Sbjct: 166 VHYCHKNGVVHRDLKLENILL---DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPE 222 Query: 197 VLK-RNY-GQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 ++ R Y G EVD W+ GV+LY L+ G PF + + + I S +++ P Sbjct: 223 IVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQI--SSGEYRE---PTQPS 277 Query: 371 NAKDLVRGML 400 +A+ L+R ML Sbjct: 278 DARGLIRWML 287
>MKNK1_BOVIN (Q58D94) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 420 Score = 75.5 bits (184), Expect = 3e-14 Identities = 50/153 (32%), Positives = 71/153 (46%), Gaps = 29/153 (18%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV--------GSPYY 184 H G+ HRDLKPEN L + ++ + +K DF L T I GS Y Sbjct: 150 HTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEY 209 Query: 185 MAPEVLK------RNYGQEVDVWSAGVILYILLCGVPPF---------WAETE------Q 301 MAPEV++ Y + D+WS GV+LYI+L G PPF W E Sbjct: 210 MAPEVVEVFTDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCTVCQN 269 Query: 302 GVAQAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 + ++I + +F W +S+ AKDL+ +L Sbjct: 270 KLFESIQKGKYEFPDKDWAHISNEAKDLISKLL 302
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 75.5 bits (184), Expect = 3e-14 Identities = 50/139 (35%), Positives = 70/139 (50%), Gaps = 9/139 (6%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYY- 184 + V+ H GV+HRDLKP N L+ ++ L+ DFG F ++ +P Y Sbjct: 521 KTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG---FAKQLRAENGLLMTPCYT 577 Query: 185 ---MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFW---AETEQGVAQAIIRSVIDFK 343 +APEVLKR Y + D+WS GV+LY +L G PF ++T + + I Sbjct: 578 ANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTLS 637 Query: 344 RDPWPRVSDNAKDLVRGML 400 W VS+ AKDLV ML Sbjct: 638 GGNWNTVSETAKDLVSKML 656 Score = 58.5 bits (140), Expect = 4e-09 Identities = 46/144 (31%), Positives = 70/144 (48%), Gaps = 23/144 (15%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAPEVLK 205 H G+++RDLKPEN L E +K DFGLS E+ G+ YMAPEV+ Sbjct: 179 HSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 235 Query: 206 R-NYGQEVDVWSAGVILYILLCGVPPFWAETEQGV------------------AQAIIRS 328 R + D WS GV+++ +L G PF + + AQ+++R+ Sbjct: 236 RQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRA 295 Query: 329 VIDFKRDPWPRVS---DNAKDLVR 391 + FKR+P R+ D A+++ R Sbjct: 296 L--FKRNPANRLGSGPDGAEEIKR 317
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 75.5 bits (184), Expect = 3e-14 Identities = 46/132 (34%), Positives = 73/132 (55%), Gaps = 4/132 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE---RFTEIVGSPYYM 187 ++ H G++HRDLKPEN L E ++ DFG + +P R VG+ Y+ Sbjct: 193 LEYLHGKGIIHRDLKPENILL---NEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 249 Query: 188 APEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 +PE+L +++ + D+W+ G I+Y L+ G+PPF A E + Q II+ DF +P+ Sbjct: 250 SPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK- 308 Query: 365 SDNAKDLVRGML 400 A+DLV +L Sbjct: 309 ---ARDLVEKLL 317
>CDC2B_ANTMA (Q38773) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 280 Score = 75.5 bits (184), Expect = 3e-14 Identities = 48/120 (40%), Positives = 61/120 (50%), Gaps = 3/120 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 V CH H V+HRDLKP+N L T +K DFGL+ F P FT V + +Y AP Sbjct: 102 VAYCHSHRVLHRDLKPQNLLIDRGSNT--IKLADFGLARAFGIPVRTFTHEVVTLWYRAP 159 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 EVL R+Y VDVWS G I ++ P F ++E I R + D WP V+ Sbjct: 160 EVLLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELHKIFRIIGTPNEDIWPGVT 219
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 75.5 bits (184), Expect = 3e-14 Identities = 49/120 (40%), Positives = 61/120 (50%), Gaps = 3/120 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 V CH H V+HRDLKP+N L + T ALK DFGL+ F P FT V + +Y AP Sbjct: 115 VAYCHSHRVLHRDLKPQNLLI--DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAP 172 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 E+L R Y VDVWS G I ++ P F ++E I R + WP VS Sbjct: 173 EILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTPNEQSWPGVS 232
>CDKL4_HUMAN (Q5MAI5) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 315 Score = 75.1 bits (183), Expect = 4e-14 Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 2/109 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 + + CH H +HRD+KPEN L + +K DFG + PG+ +T+ V + +Y A Sbjct: 112 QALNFCHIHNCIHRDIKPENILITKQ---GIIKICDFGFAQILIPGDAYTDYVATRWYRA 168 Query: 191 PEVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV 331 PE+L YG VD+W+ G + LL G P + +++ IIR++ Sbjct: 169 PELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTL 217
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 75.1 bits (183), Expect = 4e-14 Identities = 44/132 (33%), Positives = 69/132 (52%), Gaps = 2/132 (1%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E V CH + HRDLKPEN L K+ +K DFG++ P + GSP+Y + Sbjct: 225 EGVSYCHSFNICHRDLKPENLLL--DKKNRRIKIADFGMAALELPNKLLKTSCGSPHYAS 282 Query: 191 PEVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRV 364 PE++ + +G DVWS G++L+ LL G PF + + + +++ V K + Sbjct: 283 PEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPF---NDDNIKKLLLK-VQSGKYQMPSNL 338 Query: 365 SDNAKDLVRGML 400 S A+DL+ +L Sbjct: 339 SSEARDLISKIL 350
>AKT2A_XENLA (Q7ZX15) RAC-beta serine/threonine-protein kinase-A (EC 2.7.11.1)| (RAC-PK-beta-A) (Protein kinase Akt-2-A) (Protein kinase B, beta-A) (PKB beta-A) Length = 486 Score = 75.1 bits (183), Expect = 4e-14 Identities = 45/130 (34%), Positives = 70/130 (53%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGL-SVFFTPGERFTEIVGSPYYMAP 193 ++ H V++RD+K EN + + +K DFGL T G G+P Y+AP Sbjct: 268 LEYLHSRNVVYRDIKLENLML---DKDGHVKITDFGLCKEGITDGATMRTFCGTPEYLAP 324 Query: 194 EVLKRN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 EVL+ N YG+ VD W GV++Y ++CG PF+ + + + + I+ I F R +S Sbjct: 325 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPR----TLSP 380 Query: 371 NAKDLVRGML 400 AK L+ G+L Sbjct: 381 EAKSLLAGLL 390
>MKNK1_XENLA (Q9YGW0) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 418 Score = 75.1 bits (183), Expect = 4e-14 Identities = 53/155 (34%), Positives = 71/155 (45%), Gaps = 31/155 (20%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGL----------SVFFTPGERFTEIVGSP 178 H G+ HRDLKPEN L K + + +K DF L + TP T GS Sbjct: 150 HTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNSACTTITTP--ELTTPCGSA 207 Query: 179 YYMAPEVLK------RNYGQEVDVWSAGVILYILLCGVPPF---------WAETE----- 298 YMAPEV++ Y + D+WS GVILYI+L G PPF W E Sbjct: 208 EYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGTDCGWDRGEVCRVC 267 Query: 299 -QGVAQAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 + ++I +F W +S +AKDL+ +L Sbjct: 268 QNKLFESIQEGKYEFPEKDWSHISISAKDLISKLL 302
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 75.1 bits (183), Expect = 4e-14 Identities = 47/120 (39%), Positives = 63/120 (52%), Gaps = 3/120 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 + CH H V+HRDLKP+N L + T ALK DFGL+ F P FT V + +Y AP Sbjct: 115 IAYCHSHRVLHRDLKPQNLLI--DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAP 172 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 E+L R+Y VDVWS G I ++ P F ++E I R + + WP V+ Sbjct: 173 EILLGSRHYSTPVDVWSVGCIFAEMVNQRPLFPGDSEIDELFKIFRVMGTPNEETWPGVT 232
>SCK2_SCHPO (Q10364) Serine/threonine-protein kinase sck2 (EC 2.7.11.1)| Length = 646 Score = 75.1 bits (183), Expect = 4e-14 Identities = 48/131 (36%), Positives = 71/131 (54%), Gaps = 3/131 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 +Q HK G+++RDLKPEN L + A DFGLS + G G+ Y+AP Sbjct: 380 LQALHKRGIVYRDLKPENILLDVQGHIALC---DFGLSKANLSVGTTTRTFCGTTDYLAP 436 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 EV+ + Y VD WS GV+LY + CG PF+A+ Q + + I+ + F R +S Sbjct: 437 EVILDEAGYDMMVDFWSLGVLLYEMTCGWSPFYADNTQQLYKNIVFGKVRFPRG---LLS 493 Query: 368 DNAKDLVRGML 400 A+DL++ +L Sbjct: 494 VEARDLIKLLL 504
>KGP24_DROME (Q03043) cGMP-dependent protein kinase, isozyme 2 forms| cD4/T1/T3A/T3B (EC 2.7.11.12) (CGK) (Foraging protein) Length = 1088 Score = 74.7 bits (182), Expect = 5e-14 Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 3/130 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E H +++RDLKPEN L E +K +DFG + G + G+P Y+A Sbjct: 887 EAFDYLHSRNIIYRDLKPENLLL---NERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVA 943 Query: 191 PEV-LKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV--IDFKRDPWPR 361 PEV L R + D WS GV+++ LL G PPF I++ + I+F R+ Sbjct: 944 PEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRN---- 999 Query: 362 VSDNAKDLVR 391 ++ NA +L++ Sbjct: 1000 ITRNASNLIK 1009
>CDC21_ORYSA (P29618) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 294 Score = 74.7 bits (182), Expect = 5e-14 Identities = 48/120 (40%), Positives = 61/120 (50%), Gaps = 3/120 (2%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 V CH H V+HRDLKP+N L + T ALK DFGL+ F P FT V + +Y AP Sbjct: 115 VAYCHSHRVLHRDLKPQNLLI--DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAP 172 Query: 194 EVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVS 367 E+L R Y VD+WS G I ++ P F ++E I R + WP VS Sbjct: 173 EILLGSRQYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPNEQSWPGVS 232
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 74.7 bits (182), Expect = 5e-14 Identities = 49/128 (38%), Positives = 70/128 (54%), Gaps = 4/128 (3%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGE-RFTEIVGSPYYMAPEVL- 202 HK V+HRDLK N + E+ +K DFGL+ E R I G+P Y+APE+L Sbjct: 155 HKKRVIHRDLKLGNIML---DESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILF 211 Query: 203 --KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNA 376 K + EVD+WSAGV++Y LL G PPF + + + + I + F + +S A Sbjct: 212 NSKEGHSFEVDLWSAGVVMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSN--VDISAEA 269 Query: 377 KDLVRGML 400 KDL+ +L Sbjct: 270 KDLISSLL 277
>KGP25_DROME (P32023) cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 (EC| 2.7.11.12) (CGK) (Foraging protein) Length = 934 Score = 74.7 bits (182), Expect = 5e-14 Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 3/130 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E H +++RDLKPEN L E +K +DFG + G + G+P Y+A Sbjct: 733 EAFDYLHSRNIIYRDLKPENLLL---NERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVA 789 Query: 191 PEV-LKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV--IDFKRDPWPR 361 PEV L R + D WS GV+++ LL G PPF I++ + I+F R+ Sbjct: 790 PEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRN---- 845 Query: 362 VSDNAKDLVR 391 ++ NA +L++ Sbjct: 846 ITRNASNLIK 855
>RCK2_YEAST (P38623) Serine/threonine-protein kinase RCK2 (EC 2.7.11.1) (CAM| kinase-like protein kinase CLK1) Length = 610 Score = 74.7 bits (182), Expect = 5e-14 Identities = 52/160 (32%), Positives = 73/160 (45%), Gaps = 32/160 (20%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLF---------------ANKKETAA---------------- 103 V+ H GV+HRD+KPEN LF ++ +T A Sbjct: 301 VKHMHSLGVVHRDIKPENLLFEPIEFTPSIKPKLRKSDDPQTKADEGIFTPGVGGGGIGI 360 Query: 104 LKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK-RNYGQEVDVWSAGVILYILLCGVPP 280 +K DFGLS T G+ Y APEV+K +Y +VD+W G +LY +LCG PP Sbjct: 361 VKLADFGLSKQIFSKNTKTP-CGTVGYTAPEVVKDEHYSMKVDMWGIGCVLYTMLCGFPP 419 Query: 281 FWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 F+ E + + I R F + W +S AK+ V +L Sbjct: 420 FYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVSKLL 459
>MKNK1_MOUSE (O08605) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 427 Score = 74.7 bits (182), Expect = 5e-14 Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 29/153 (18%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIV--------GSPYY 184 H G+ HRDLKPEN L + ++ + +K DF L T I GS Y Sbjct: 162 HTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEY 221 Query: 185 MAPEVLK------RNYGQEVDVWSAGVILYILLCGVPPF---------WAETE------Q 301 MAPEV++ Y + D+WS GV+LYI+L G PPF W E Sbjct: 222 MAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQN 281 Query: 302 GVAQAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 + ++I +F W +S+ AKDL+ +L Sbjct: 282 KLFESIQEGKYEFPDKDWAHISNEAKDLISKLL 314
>RCK1_YEAST (P38622) Serine/threonine-protein kinase RCK1 (EC 2.7.11.1)| Length = 512 Score = 74.7 bits (182), Expect = 5e-14 Identities = 48/150 (32%), Positives = 73/150 (48%), Gaps = 22/150 (14%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFA-----------NKKETAAL----------KAIDFGLSV 133 ++ H G++HRD+KPEN LF K++ L K +DFGL+ Sbjct: 247 IKHMHYMGIVHRDVKPENLLFEPIPFYGLDGDMQKEDEFTLGVGGGGIGLVKLMDFGLAK 306 Query: 134 FFTPGERFTEIVGSPYYMAPEVL-KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVA 310 T G+ Y+A EV + Y +VD+WS G +L+ LLCG PPF+ + E+ + Sbjct: 307 KLRNNTAKTPC-GTIEYVASEVFTSKRYSMKVDMWSIGCVLFTLLCGYPPFYEKNEKTLL 365 Query: 311 QAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 + I R +F W +S AK+ V +L Sbjct: 366 KKISRGDYEFLAPWWDNISSGAKNAVTHLL 395
>MKNK2_XENTR (Q66I46) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 466 Score = 74.7 bits (182), Expect = 5e-14 Identities = 56/161 (34%), Positives = 72/161 (44%), Gaps = 31/161 (19%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGL----------SVFFTPGERFT 160 E + H G+ HRDLKPEN L + + + +K DF L S TP E T Sbjct: 190 EALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIKLNSDCSPISTP-ELLT 248 Query: 161 EIVGSPYYMAPEVLKRN------YGQEVDVWSAGVILYILLCGVPPF---------WAET 295 GS YMAPEV++ Y + D+WS GVILYI+L G PPF W Sbjct: 249 PC-GSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGHCGSDCGWDRG 307 Query: 296 EQGVA------QAIIRSVIDFKRDPWPRVSDNAKDLVRGML 400 E A +I +F W +S AKDL+ +L Sbjct: 308 EACPACQNMLFVSIQEGKYEFPEKDWAHISSGAKDLISKLL 348
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 74.7 bits (182), Expect = 5e-14 Identities = 38/92 (41%), Positives = 54/92 (58%), Gaps = 3/92 (3%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFT-PGERFTEIVGSPYYM 187 + V CHKH +HRD+KPEN L + + +K DFG + T PG+ +T+ V + +Y Sbjct: 112 QAVNFCHKHNCIHRDVKPENILIT---KHSVIKLCDFGFARLLTGPGDYYTDYVATRWYR 168 Query: 188 APEVL--KRNYGQEVDVWSAGVILYILLCGVP 277 +PE+L YG VDVW+ G + LL GVP Sbjct: 169 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVP 200
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 74.3 bits (181), Expect = 6e-14 Identities = 49/139 (35%), Positives = 71/139 (51%), Gaps = 9/139 (6%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYY- 184 + V+ H GV+HRDLKP N L+ ++ +++ DFG F ++ +P Y Sbjct: 538 KTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFG---FAKQLRAENGLLMTPCYT 594 Query: 185 ---MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFW---AETEQGVAQAIIRSVIDFK 343 +APEVLKR Y + D+WS GV+LY +L G PF ++T + + I Sbjct: 595 ANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSVN 654 Query: 344 RDPWPRVSDNAKDLVRGML 400 W +SD AKDLV ML Sbjct: 655 GGNWDTISDVAKDLVSKML 673 Score = 59.3 bits (142), Expect = 2e-09 Identities = 46/144 (31%), Positives = 70/144 (48%), Gaps = 23/144 (15%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAPEVLK 205 H G+++RDLKPEN L E +K DFGLS E+ G+ YMAPEV+ Sbjct: 197 HSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 253 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPFWAETEQ------------------GVAQAIIRS 328 R + D WS GV+++ +L G PF + + AQ+++R+ Sbjct: 254 RQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSAEAQSLLRA 313 Query: 329 VIDFKRDPWPRVS---DNAKDLVR 391 + FKR+P R+ D A+++ R Sbjct: 314 L--FKRNPANRLGSGPDGAEEIKR 335
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 74.3 bits (181), Expect = 6e-14 Identities = 42/130 (32%), Positives = 65/130 (50%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPE 196 + CH + + HRDLKPEN L K ++ DFG++ GSP+Y PE Sbjct: 160 LDFCHSYSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETSCGSPHYACPE 216 Query: 197 VLK--RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 V+K + G+ D+WS GVIL+ LL G PF + + + + + R V + Sbjct: 217 VIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPH----FIPP 272 Query: 371 NAKDLVRGML 400 + + L+RGM+ Sbjct: 273 DCQSLLRGMI 282
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 74.3 bits (181), Expect = 6e-14 Identities = 49/139 (35%), Positives = 70/139 (50%), Gaps = 9/139 (6%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYY- 184 + V+ H GV+HRDLKP N L+ ++ L+ DFG F ++ +P Y Sbjct: 521 KTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG---FAKQLRAENGLLMTPCYT 577 Query: 185 ---MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFW---AETEQGVAQAIIRSVIDFK 343 +APEVLKR Y + D+WS G++LY +L G PF ++T + + I Sbjct: 578 ANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLS 637 Query: 344 RDPWPRVSDNAKDLVRGML 400 W VS+ AKDLV ML Sbjct: 638 GGNWNTVSETAKDLVSKML 656 Score = 59.3 bits (142), Expect = 2e-09 Identities = 46/144 (31%), Positives = 70/144 (48%), Gaps = 23/144 (15%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAPEVLK 205 H G+++RDLKPEN L E +K DFGLS E+ G+ YMAPEV+ Sbjct: 179 HSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 235 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGV------------------AQAIIRS 328 R + D WS GV+++ +L G PF + + AQ+++R+ Sbjct: 236 RQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRA 295 Query: 329 VIDFKRDPWPRVS---DNAKDLVR 391 + FKR+P R+ D A+++ R Sbjct: 296 L--FKRNPANRLGSGPDGAEEIKR 317
>KGP2_HUMAN (Q13237) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 74.3 bits (181), Expect = 6e-14 Identities = 43/130 (33%), Positives = 70/130 (53%), Gaps = 3/130 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMA 190 E H+ G+++RDLKPEN + + LK +DFG + G++ G+P Y+A Sbjct: 562 EAFDYLHRLGIIYRDLKPENLILDAE---GYLKLVDFGFAKKIGSGQKTWTFCGTPEYVA 618 Query: 191 PEV-LKRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSV--IDFKRDPWPR 361 PEV L + + VD WS G+++Y LL G PPF + I++ + +DF R + Sbjct: 619 PEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPR----K 674 Query: 362 VSDNAKDLVR 391 ++ +DL+R Sbjct: 675 ITRRPEDLIR 684
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 74.3 bits (181), Expect = 6e-14 Identities = 44/126 (34%), Positives = 68/126 (53%), Gaps = 2/126 (1%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFT-PGERFTEIVGSPYYMAPEVLK 205 H HG++HRDL N L +K DFGL+ P E+ + G+P Y++PE+ Sbjct: 128 HSHGILHRDLTLSNLLLTRNMN---IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIAT 184 Query: 206 RN-YGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKD 382 R+ +G E DVWS G + Y LL G PPF +T + ++ + D++ + +S AKD Sbjct: 185 RSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV--LADYEMPTF--LSIEAKD 240 Query: 383 LVRGML 400 L+ +L Sbjct: 241 LIHQLL 246
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 74.3 bits (181), Expect = 6e-14 Identities = 49/139 (35%), Positives = 70/139 (50%), Gaps = 9/139 (6%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKK-ETAALKAIDFGLSVFFTPGERFTEIVGSPYY- 184 + V+ H GV+HRDLKP N L+ ++ L+ DFG F ++ +P Y Sbjct: 510 KTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG---FAKQLRAENGLLMTPCYT 566 Query: 185 ---MAPEVLKRN-YGQEVDVWSAGVILYILLCGVPPFW---AETEQGVAQAIIRSVIDFK 343 +APEVLKR Y + D+WS G++LY +L G PF ++T + + I Sbjct: 567 ANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLS 626 Query: 344 RDPWPRVSDNAKDLVRGML 400 W VS+ AKDLV ML Sbjct: 627 GGNWNTVSETAKDLVSKML 645 Score = 53.5 bits (127), Expect = 1e-07 Identities = 45/137 (32%), Positives = 67/137 (48%), Gaps = 16/137 (11%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFT-EIVGSPYYMAPEVLK 205 H G+++RDLKPEN L E +K DFGLS E+ G+ YMAPEV+ Sbjct: 179 HSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 235 Query: 206 R-NYGQEVDVWSAGVI--------LYILL---CGVPPFWAETEQGVAQAIIRSVIDFKRD 349 R + D WS GV+ + ++L G+P F + Q + +A+ FKR+ Sbjct: 236 RQGHTHSADWWSYGVLMGKDRKETMTLILKAKLGMPQFLSTEAQSLLRAL------FKRN 289 Query: 350 PWPRVS---DNAKDLVR 391 P R+ D A+++ R Sbjct: 290 PANRLGSGPDGAEEIKR 306
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 74.3 bits (181), Expect = 6e-14 Identities = 48/121 (39%), Positives = 60/121 (49%), Gaps = 3/121 (2%) Frame = +2 Query: 11 EVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYM 187 E + CH+ V+HRDLKP+N L NK +K DFGLS F P +T V + +Y Sbjct: 114 EGIYFCHRRRVLHRDLKPQNLLIDNK---GVIKLADFGLSRAFGVPVRVYTHEVVTLWYR 170 Query: 188 APEVL--KRNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPR 361 APEVL Y VDVWS G I L P F ++E I R++ D WP Sbjct: 171 APEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPD 230 Query: 362 V 364 V Sbjct: 231 V 231
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 73.9 bits (180), Expect = 8e-14 Identities = 36/97 (37%), Positives = 59/97 (60%), Gaps = 3/97 (3%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLS-VFFTPGERFTEIVGSPYYMAP 193 + CH H ++HRD+KPEN L + ++ +K DFG + PGE +T+ V + +Y AP Sbjct: 114 IGFCHSHNIIHRDIKPENILVS---QSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAP 170 Query: 194 EVLKRN--YGQEVDVWSAGVILYILLCGVPPFWAETE 298 E+L + YG+ VD+W+ G ++ +L G P F E++ Sbjct: 171 ELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESD 207
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 73.9 bits (180), Expect = 8e-14 Identities = 44/125 (35%), Positives = 65/125 (52%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 HK +++RDLKPEN L ++ DFGLS + G+P Y+APEVL Sbjct: 268 HKQDIVYRDLKPENILLDSEGHICIT---DFGLSKKIETTDGTFTFCGTPEYLAPEVLNG 324 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 +G VD WS G +LY +L G+PPF+++ + Q I+ + +S AK L Sbjct: 325 HGHGCAVDWWSLGTLLYEMLTGLPPFYSQNVSTMYQKILNGELKIP----TYISPEAKSL 380 Query: 386 VRGML 400 + G+L Sbjct: 381 LEGLL 385
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 73.9 bits (180), Expect = 8e-14 Identities = 42/125 (33%), Positives = 67/125 (53%), Gaps = 1/125 (0%) Frame = +2 Query: 29 HKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLK- 205 HK ++HRD+KPEN L +K DFG S+ P R + G+ Y++PE+++ Sbjct: 219 HKKNIIHRDIKPENILIGFNN---VIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVES 275 Query: 206 RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDL 385 R Y +D W+ GV+ + LL G PPF E + + I + +D K +S +A+DL Sbjct: 276 REYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRI--AALDIKMP--SNISQDAQDL 331 Query: 386 VRGML 400 + +L Sbjct: 332 ILKLL 336
>GAD8_SCHPO (Q9P7J8) Serine/threonine-protein kinase gad8 (EC 2.7.11.1)| Length = 569 Score = 73.9 bits (180), Expect = 8e-14 Identities = 44/130 (33%), Positives = 71/130 (54%), Gaps = 2/130 (1%) Frame = +2 Query: 17 VQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGL-SVFFTPGERFTEIVGSPYYMAP 193 ++ H+ V++RDLKPEN L T + DFGL + +R G+P Y+AP Sbjct: 341 LECLHEFNVIYRDLKPENILL---DYTGHIALCDFGLCKLNMAKTDRTNTFCGTPEYLAP 397 Query: 194 EVLK-RNYGQEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSD 370 E+L Y + VD W+ GV+LY ++ G+PPF+ E + + I++ + F + + Sbjct: 398 ELLLGHGYTKVVDWWTLGVLLYEMITGLPPFYDENINEMYRKILQDPLRFP----DNIDE 453 Query: 371 NAKDLVRGML 400 AKDL+ G+L Sbjct: 454 KAKDLLSGLL 463 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 61,406,076 Number of Sequences: 219361 Number of extensions: 1248161 Number of successful extensions: 7336 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5161 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5376 length of database: 80,573,946 effective HSP length: 109 effective length of database: 56,663,597 effective search space used: 1359926328 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
