>BIG2_HUMAN (Q9Y6D5) Brefeldin A-inhibited guanine nucleotide-exchange protein 2|
            (Brefeldin A-inhibited GEP 2)
          Length = 1785

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 53/207 (25%), Positives = 95/207 (45%), Gaps = 1/207 (0%)
 Frame = +3

Query: 27   IIEKILRDYFPYITETESSTFTDCVNCLIAFTNSRFNKDISLNAIGFLRFCAAKLAEGDI 206
            I+  I + +FP   ++    F D V CL  F  +    D S+ AI  +RFC   ++E   
Sbjct: 1251 IVTTIFQHHFPAAIDS----FQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSE--- 1303

Query: 207  GSSSRLKEPSSHLTKDGKQEGAIQVDKDDTIHFWFPLLAGLSELTFDLRPEIRKSSLQVL 386
                R +    + + D       +V     +  WFP+L  LS +    + ++R   L V+
Sbjct: 1304 ----RPRVLQEYTSDDMNVAPGDRV----WVRGWFPILFELSCIINRCKLDVRTRGLTVM 1355

Query: 387  FDTLRNHGHLFSLPLWEKVFDSVLFPIFDYVRHAIDPSGGSSQGQNAENDPAEL-DQDAW 563
            F+ ++++GH F    W+ +F  ++F IFD ++                  P +L ++  W
Sbjct: 1356 FEIMKSYGHTFEKHWWQDLF-RIVFRIFDNMKL-----------------PEQLSEKSEW 1397

Query: 564  MYETCTLALQLVVDLFVKFYDTVHPLL 644
            M  TC  AL  + D+F +FY+ ++ +L
Sbjct: 1398 MTTTCNHALYAICDVFTQFYEALNEVL 1424

>BIG1_HUMAN (Q9Y6D6) Brefeldin A-inhibited guanine nucleotide-exchange protein 1|
            (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF
            guanine nucleotide exchange factor)
          Length = 1849

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 49/208 (23%), Positives = 90/208 (43%), Gaps = 2/208 (0%)
 Frame = +3

Query: 27   IIEKILRDYFPYITETESSTFTDCVNCLIAFTNSRFNKDISLNAIGFLRFCAAKLAEGDI 206
            I+  +   +FP   ++    F D V CL  F  +    D S+ AI  +R CA  +++   
Sbjct: 1304 IVTLVFEKHFPATIDS----FQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSD--- 1356

Query: 207  GSSSRLKEPSSHLTKDGKQEGAIQVDKDDTIHF--WFPLLAGLSELTFDLRPEIRKSSLQ 380
                  KE +S           + V  +D +    WFP+L  LS +    + ++R   L 
Sbjct: 1357 -RPQAFKEYTSD---------DMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLT 1406

Query: 381  VLFDTLRNHGHLFSLPLWEKVFDSVLFPIFDYVRHAIDPSGGSSQGQNAENDPAELDQDA 560
            V+F+ ++ +GH +    W+ +F  ++F IFD                N +    + ++  
Sbjct: 1407 VMFEIMKTYGHTYEKHWWQDLF-RIVFRIFD----------------NMKLPEQQTEKAE 1449

Query: 561  WMYETCTLALQLVVDLFVKFYDTVHPLL 644
            WM  TC  AL  + D+F ++ + +  +L
Sbjct: 1450 WMTTTCNHALYAICDVFTQYLEVLSDVL 1477

>SEC7_YEAST (P11075) Protein transport protein SEC7|
          Length = 2009

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 54/211 (25%), Positives = 94/211 (44%), Gaps = 2/211 (0%)
 Frame = +3

Query: 39   ILRDYFPYITETESSTFTDCVNCLIAFT-NSRFNKDISLNAIGFLRFCAAKLAEGDIGSS 215
            I+ ++F  +   E + F++ V      T N RF K +SL+A+  LR     +A+    + 
Sbjct: 1454 IVTNHFENVFSQEDA-FSELVGVFREITKNKRFQK-LSLHALESLRKMTQNVADICFYNE 1511

Query: 216  SRLKEPSSHLTKDGKQEGAIQVDKDDTIHFWFPLLAGLSELTFDLRP-EIRKSSLQVLFD 392
            ++ +E   H         A+   KD     WFP+L   ++        E+R  +L  +FD
Sbjct: 1512 NKTEEERKH-------NDALLRGKDIFQDVWFPMLFCFNDTIMTAEDLEVRSRALNYMFD 1564

Query: 393  TLRNHGHLFSLPLWEKVFDSVLFPIFDYVRHAIDPSGGSSQGQNAENDPAELDQDAWMYE 572
             L  +G  F+   WEK+   +LFPIF          G  S+        +  D   W+  
Sbjct: 1565 ALVAYGGKFNDDFWEKICKKLLFPIF----------GVLSKHWEVNQFNSHDDLSVWLST 1614

Query: 573  TCTLALQLVVDLFVKFYDTVHPLLKKVLSLL 665
            T   AL+ ++ LF  ++++++ +L   L LL
Sbjct: 1615 TLIQALRNLIALFTHYFESLNRMLDGFLGLL 1645

>BIG1_BOVIN (O46382) Brefeldin A-inhibited guanine nucleotide-exchange protein 1|
            (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF
            guanine nucleotide exchange factor)
          Length = 1849

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 48/208 (23%), Positives = 90/208 (43%), Gaps = 2/208 (0%)
 Frame = +3

Query: 27   IIEKILRDYFPYITETESSTFTDCVNCLIAFTNSRFNKDISLNAIGFLRFCAAKLAEGDI 206
            I+  +   +FP   ++    F D V CL  F  +    D S+ AI  +R CA  +++   
Sbjct: 1304 IVTLVFEKHFPATIDS----FQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSD--- 1356

Query: 207  GSSSRLKEPSSHLTKDGKQEGAIQVDKDDTIHF--WFPLLAGLSELTFDLRPEIRKSSLQ 380
                  KE +S           + V  +D +    WFP+L  LS +    + ++R   L 
Sbjct: 1357 -RPQAFKEYTSD---------DMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLT 1406

Query: 381  VLFDTLRNHGHLFSLPLWEKVFDSVLFPIFDYVRHAIDPSGGSSQGQNAENDPAELDQDA 560
            V+F+ ++ +G+ +    W+ +F  ++F IFD                N +    + ++  
Sbjct: 1407 VMFEIMKTYGYTYEKHWWQDLF-RIVFRIFD----------------NMKLPEQQTEKAE 1449

Query: 561  WMYETCTLALQLVVDLFVKFYDTVHPLL 644
            WM  TC  AL  + D+F ++ + +  +L
Sbjct: 1450 WMTTTCNHALYAICDVFTQYLEVLSDVL 1477

>SEC71_SCHPO (Q9UT02) Protein transport protein sec71|
          Length = 1811

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 48/194 (24%), Positives = 83/194 (42%), Gaps = 1/194 (0%)
 Frame = +3

Query: 87   FTDCVNCLIAFTNSRFNKDISLNAIGFLRFCAAKLAEGDIGSSSRLKEPSSHLTKDGKQE 266
            + D ++C+  F     N+   L+ +  L+    +L +        LK    H+ K+    
Sbjct: 1346 YIDLISCITKFAKLNGNQKFCLSCVDMLKNLEHELIK-------HLK----HMKKESVYS 1394

Query: 267  GAIQVDKDDTIHFWFPLLAGLSELTFDLRP-EIRKSSLQVLFDTLRNHGHLFSLPLWEKV 443
              ++ +      +W P L   +E+  +    E+R  +L+VLFD L  H   F    WE V
Sbjct: 1395 KKLEEE------YWLPFLLSFNEIICEASDLEVRSKALKVLFDCLYRHADDFDEEFWETV 1448

Query: 444  FDSVLFPIFDYVRHAIDPSGGSSQGQNAENDPAELDQDAWMYETCTLALQLVVDLFVKFY 623
             +  L  IF  +  +I  S      +N E      + + WM  T   AL+  ++L    +
Sbjct: 1449 SNKALLSIFSIL--SITNSQRLYLAKNTE------ETEVWMLTTMVEALKAFIELIKNLF 1500

Query: 624  DTVHPLLKKVLSLL 665
            + +H LL K L+LL
Sbjct: 1501 ERLHFLLPKALNLL 1514

>GBF1_CRIGR (Q9R1D7) Golgi-specific brefeldin A-resistance guanine nucleotide|
            exchange factor 1 (BFA-resistant GEF 1)
          Length = 1856

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 2/93 (2%)
 Frame = +3

Query: 228  EPSSHLTKDGKQEGAIQVDKDDT-IHFWFPLLAGLSELTFDLRPEIRKSSLQVLFDTLRN 404
            E   HL   G++   I+ D      H W PLL G++ L  D R ++R  +L  L   L  
Sbjct: 1518 EEQRHLESGGRK---IEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLV 1574

Query: 405  HG-HLFSLPLWEKVFDSVLFPIFDYVRHAIDPS 500
            H         WE  F+ VLFP+   +   I P+
Sbjct: 1575 HDLQKLDALEWESCFNKVLFPLLTKLLENISPA 1607

>GBF1_HUMAN (Q92538) Golgi-specific brefeldin A-resistance guanine nucleotide|
            exchange factor 1 (BFA-resistant GEF 1)
          Length = 1859

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 2/93 (2%)
 Frame = +3

Query: 228  EPSSHLTKDGKQEGAIQVDKDDT-IHFWFPLLAGLSELTFDLRPEIRKSSLQVLFDTLRN 404
            E   HL   G++   I+ D      H W PLL G++ L  D R ++R  +L  L   L  
Sbjct: 1518 EEQRHLETGGQK---IEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLV 1574

Query: 405  HG-HLFSLPLWEKVFDSVLFPIFDYVRHAIDPS 500
            H         WE  F+ VLFP+   +   I P+
Sbjct: 1575 HDLQKLDALEWESCFNKVLFPLLTKLLENISPA 1607

>SEC72_SCHPO (Q9P7V5) Protein transport protein sec72|
          Length = 1822

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 34/122 (27%), Positives = 48/122 (39%), Gaps = 4/122 (3%)
 Frame = +3

Query: 309  FPLLAGLSELTFDLRP-EIRKSSLQVLFDTLRNHGHLFSLPLWEKVFDSVLFPIFDYVRH 485
            FP+L    ++       E+R  +LQ LF         F+   WE V    +FPIF     
Sbjct: 1403 FPVLFAYYDIIMSAEDLEVRSRALQNLFYIFLEESDDFTEETWEVVSRKFIFPIF----- 1457

Query: 486  AIDPSGGSSQGQNAENDPAELDQD---AWMYETCTLALQLVVDLFVKFYDTVHPLLKKVL 656
                   S  G  A+     L  +    W   T   AL+ +V L  + +D +H LLK  L
Sbjct: 1458 -------SIFGPEADEATVMLRDEEIRTWQSTTLVEALRSLVTLLTRRFDKLHNLLKGYL 1510

Query: 657  SL 662
             L
Sbjct: 1511 WL 1512

>C8AP2_HUMAN (Q9UKL3) CASP8-associated protein 2 (FLICE-associated huge protein)|
          Length = 1982

 Score = 36.2 bits (82), Expect = 0.091
 Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
 Frame = -3

Query: 394  VSNNTCKELFLISGLRSKVSSDNPANKGNQKCIVSSLST*IAPSCFPS-LVK*DEGSFSL 218
            V NN+ K++FL +   S   S +  NK NQK I  S     A +C  S L + +EG    
Sbjct: 881  VYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRS 940

Query: 217  EEDPMSPSASFAAQNRRK 164
            + +   P  SF   ++R+
Sbjct: 941  DSETSKPQESFEKNSKRR 958

>EMB30_ARATH (Q42510) Pattern formation protein EMB30|
          Length = 1451

 Score = 35.4 bits (80), Expect = 0.15
 Identities = 32/138 (23%), Positives = 55/138 (39%), Gaps = 2/138 (1%)
 Frame = +3

Query: 66   TETESSTFTDCVNCLIAFTNSRFNK-DISLNAIGFLRFCAAKLAEGDIGSSSRLKEPSSH 242
            T    + +  CV+    F  SR  + + S+ A+  +      LA+  + +   + E    
Sbjct: 1176 THLYPANYVLCVDAARQFAESRVGQSERSIRALDLMGDSLEFLAKWALSAKENMGEEDF- 1234

Query: 243  LTKDGKQEGAIQVDKDDTIHFWFPLLAGLSELTFDLRPEIRKSSLQVLFDTLRN-HGHLF 419
                GK          D    W  L+ GL ++  D R ++R  +LQ L   L    G   
Sbjct: 1235 ----GKMS-------QDIGEMWLRLVQGLRKVCLDQREDVRNHALQSLQKCLGGVDGINL 1283

Query: 420  SLPLWEKVFDSVLFPIFD 473
            +  +W + FD V+F + D
Sbjct: 1284 AHSMWSQCFDKVIFTVLD 1301

>LEP_BACCL (P41027) Signal peptidase I (EC 3.4.21.89) (SPase I) (Leader|
           peptidase I)
          Length = 182

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 18/53 (33%), Positives = 24/53 (45%)
 Frame = -3

Query: 424 REKRWPWFLNVSNNTCKELFLISGLRSKVSSDNPANKGNQKCIVSSLST*IAP 266
           R +RWPWF+ V       LF+ S    +  S  P  +     IV+ LS  I P
Sbjct: 8   RGRRWPWFVAVCVVATLRLFVFSNYVVEGKSMMPTLESGNLLIVNKLSYDIGP 60

>BGAL_LACAC (O07684) Beta-galactosidase large subunit (EC 3.2.1.23) (Lactase)|
          Length = 628

 Score = 30.4 bits (67), Expect = 5.0
 Identities = 15/56 (26%), Positives = 27/56 (48%)
 Frame = +3

Query: 225 KEPSSHLTKDGKQEGAIQVDKDDTIHFWFPLLAGLSELTFDLRPEIRKSSLQVLFD 392
           + P+  L K   +EG+    KD+T+  +           FDL PE+R   + ++F+
Sbjct: 106 RRPAYALNKSDAEEGSFSEGKDNTVGSYIK--------HFDLNPELRDHDIHIVFE 153

>DONS_MOUSE (Q9QXP4) Downstream neighbor of Son protein (Protein 3SG)|
          Length = 560

 Score = 30.0 bits (66), Expect = 6.5
 Identities = 29/93 (31%), Positives = 43/93 (46%)
 Frame = +3

Query: 294 TIHFWFPLLAGLSELTFDLRPEIRKSSLQVLFDTLRNHGHLFSLPLWEKVFDSVLFPIFD 473
           T+ F    LAG S +T  + P  R      L + +RN G  FSLPL E++          
Sbjct: 284 TVLFRAAGLAGSSVITALISPTTRG-----LREAMRNEGIEFSLPLLEEI---------G 329

Query: 474 YVRHAIDPSGGSSQGQNAENDPAELDQDAWMYE 572
           + +   DPS  S + Q A +D  E +  +W+ E
Sbjct: 330 HKKKVRDPSLESEEEQ-AVSDEDEEESFSWLEE 361

>AF17_HUMAN (P55198) Protein AF-17|
          Length = 1093

 Score = 29.6 bits (65), Expect = 8.5
 Identities = 26/91 (28%), Positives = 44/91 (48%)
 Frame = -3

Query: 463 GKSTESNTFSHKGREKRWPWFLNVSNNTCKELFLISGLRSKVSSDNPANKGNQKCIVSSL 284
           GK + S++ SHKG++           ++ K +   +   S  SS + ++ G  +  VSSL
Sbjct: 300 GKKSSSHSLSHKGKKL----------SSGKGVSSFTSASSSSSSSSSSSGGPFQPAVSSL 349

Query: 283 ST*IAPSCFPSLVK*DEGSFSLEEDPMSPSA 191
            +    S FP L + +E  +S    P +PSA
Sbjct: 350 QSSPDFSAFPKLEQPEEDKYSKPTAP-APSA 379


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,132,891
Number of Sequences: 219361
Number of extensions: 1847245
Number of successful extensions: 5035
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 4878
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5025
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6427774254
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)