>COG8_HUMAN (Q96MW5) Conserved oligomeric Golgi complex component 8|
          Length = 612

 Score =  184 bits (466), Expect = 3e-46
 Identities = 85/217 (39%), Positives = 136/217 (62%)
 Frame = +3

Query: 3   RXVAVENYAAFIAASEALSFVRAQLEGFDKHLEALVEEIPNLTSGCTEFVESAHQILEER 182
           R +A  NY  FI  +E    +       +  L  L++ +P+    C  FV+ A +I   R
Sbjct: 80  RDLAFANYKTFIRGAECTERIHRLFGDVEASLGRLLDRLPSFQQSCRNFVKEAEEISSNR 139

Query: 183 KLNQTLLANHSTLLDLLEIPQLMDTCIRNGNYDEALDLEAFVSKISKLHPDLPVIQGLAA 362
           ++N   L  H+ +L++LEIPQLMDTC+RN  Y+EAL+L A+V ++ + +  +PVIQG+  
Sbjct: 140 RMNSLTLNRHTEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVN 199

Query: 363 EVKKTXXXXXXXXXXKLRSNIQLPECLRIVAHLRRIGVFSESELRLQFLRCREAWLSGIL 542
           EV+++          +LR+NIQLP CLR++ +LRR+ VF+E+ELR++FL+ R+AWL  IL
Sbjct: 200 EVRQSMQLMLSQLIQQLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSIL 259

Query: 543 DDLDQRNVYDYLKGMVTCHRTHLFDVVNQYRAIFNND 653
             +   + Y ++   +   R HLFD++ QYRAIF+++
Sbjct: 260 TAIPNDDPYFHITKTIEASRVHLFDIITQYRAIFSDE 296

>COG8_MOUSE (Q9JJA2) Conserved oligomeric Golgi complex component 8|
          Length = 640

 Score =  182 bits (461), Expect = 1e-45
 Identities = 87/241 (36%), Positives = 142/241 (58%), Gaps = 6/241 (2%)
 Frame = +3

Query: 3   RXVAVENYAAFIAASEALSFVRAQLEGFDKHLEALVEEIPNLTSGCTEFVESAHQILEER 182
           R +A  NY  FI  +E    +       +  L  L++ +P     C  FV+ A +I   R
Sbjct: 86  RDLAFANYKTFIRGAECTERIHRLFGDVEASLGRLLDRLPRFQQSCRNFVKEAEEISSSR 145

Query: 183 KLNQTLLANHSTLLDLLEIPQLMDTCIRNGNYDEALDLEAFVSKISKLHPDLPVIQGLAA 362
           ++N   L  H+ +L++LEIPQLMDTC+RN  ++EAL+L A+V ++ + +  +PVIQG+  
Sbjct: 146 RMNTLTLNRHTEILEILEIPQLMDTCVRNSYHEEALELAAYVRRLERKYSSIPVIQGIVN 205

Query: 363 EVKKTXXXXXXXXXXKLRSNIQLPECLRIVAHLRRIGVFSESELRLQFLRCREAWLSGIL 542
           EV+++          +LR+NIQLP CLR++ +LRR+ VF+E+ELR++FL+ R+AWL  IL
Sbjct: 206 EVRQSMQLMLSQLIQQLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSIL 265

Query: 543 DDLDQRNVYDYLKGMVTCHRTHLFDVVNQYRAIFNND------KSGSEENSDGGLLFSWA 704
             +   + Y ++   +   R HLFD++ QYRAIF+++        G    ++G +   W 
Sbjct: 266 TAIPNDDPYFHITKTIEACRVHLFDIITQYRAIFSDEDPLLPPAMGEYTVNEGAIFHGWV 325

Query: 705 M 707
           +
Sbjct: 326 L 326

>COG8_DROME (Q9VKH0) Putative conserved oligomeric Golgi complex component 8|
          Length = 570

 Score =  160 bits (404), Expect = 5e-39
 Identities = 74/216 (34%), Positives = 135/216 (62%)
 Frame = +3

Query: 9   VAVENYAAFIAASEALSFVRAQLEGFDKHLEALVEEIPNLTSGCTEFVESAHQILEERKL 188
           +A+ NY  FI  +E    + ++    ++ L+ LV ++P+L+  C  F++ + ++ E+R+L
Sbjct: 69  LAISNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRL 128

Query: 189 NQTLLANHSTLLDLLEIPQLMDTCIRNGNYDEALDLEAFVSKISKLHPDLPVIQGLAAEV 368
           N   L  ++ LL++LE+PQLM+ CIR G Y+EAL+L A+ +++ +    +PV+  +   V
Sbjct: 129 NSITLQKNAQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSV 188

Query: 369 KKTXXXXXXXXXXKLRSNIQLPECLRIVAHLRRIGVFSESELRLQFLRCREAWLSGILDD 548
           +            +LR+++QLP+CL+IV +LRR+  F ++ELRL+FL+ R+AWL+  L+ 
Sbjct: 189 EALWHNMLVQLVAQLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEA 248

Query: 549 LDQRNVYDYLKGMVTCHRTHLFDVVNQYRAIFNNDK 656
           +   +   +L   +   R +LF+++ QYRAIF  D+
Sbjct: 249 IPTADAQQHLSKTIEITRINLFNIITQYRAIFPEDE 284

>COG8_CAEEL (O44502) Putative conserved oligomeric Golgi complex component 8|
          Length = 743

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 56/228 (24%), Positives = 104/228 (45%), Gaps = 4/228 (1%)
 Frame = +3

Query: 9   VAVENYAAFIAASEALSFVRAQLEGFDKHLEALVEEIPNLTSGCTEFVESAHQILEERKL 188
           +A  NY  +  A  A                 L ++   LTS   EF   A Q+ EE+ L
Sbjct: 42  LAFNNYGTYADAGRATHDCSKTFGEMRDKTVNLSDQAEELTSAFVEFRAKAKQLSEEQDL 101

Query: 189 NQTLLANHSTLLDLLEIPQLMDTCIRNGNYDEALDLEAF---VSKISKLHPDLPVIQGLA 359
            +  L   + + +LL +P  MD CIR G YD A  L  +   + + ++L+ + P+I+ +A
Sbjct: 102 VRKALDKSNPIWELLTLPSRMDICIRAGYYDLAYTLTNYGLQLQQQTQLYRN-PLIKKVA 160

Query: 360 AEVKKTXXXXXXXXXXKLRSNIQLPECLRIVAHLRRIGVFSESELRLQFLRCREAWLSGI 539
             + +           K    + L E +++V ++R++   + ++LR+  L+ R+ +L   
Sbjct: 161 DHLVEARAYLLEELFNKFAGPLDLAESIKVVNNVRKMPSLTANQLRIAVLQHRDIYLEKQ 220

Query: 540 LDDLDQRNVYDYLKGMVTCHRTHLFDVVNQYRAIF-NNDKSGSEENSD 680
           +  LD     D +   +  +RT ++D +  Y A+F  N+      N+D
Sbjct: 221 I--LDISGNVDMIVQAIEIYRTSMYDTLVLYLAVFPENEVVRKNPNAD 266

>COG8_YEAST (Q04632) Conserved oligomeric Golgi complex component 8|
          Length = 607

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 11/169 (6%)
 Frame = +3

Query: 195 TLLANHSTLLDLLEIPQLMDTCIRNGNYDEALDLEAFVSKISKLHPDLPVIQGLAAEVKK 374
           T+L N  ++ DL+E+P L  TCIR G+Y EA+ L    + +    P   ++  +  +V  
Sbjct: 189 TVLENLDSITDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLN 248

Query: 375 TXXXXXXXXXXKLRS-NIQLPECLRIVAHLRRIGVF---SESELRLQFLRCREAWLSGIL 542
                      KL S N+ +    +I+ +L  I  F   +   L   FL  R  +++  +
Sbjct: 249 EISTTMLSGLVKLLSTNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEI 308

Query: 543 D----DLDQRN---VYDYLKGMVTCHRTHLFDVVNQYRAIFNNDKSGSE 668
                D++  N   +   +K  +   R H++  +N +   F  D +  E
Sbjct: 309 ASYPLDVESSNESLIEMMVKRKIEVLREHVYMSLNVFLKSFLYDTNDLE 357

>CK002_HUMAN (Q9UID3) Protein C11orf2 (Another new gene 2 protein)|
          Length = 782

 Score = 35.4 bits (80), Expect = 0.17
 Identities = 25/122 (20%), Positives = 52/122 (42%), Gaps = 4/122 (3%)
 Frame = +3

Query: 3   RXVAVENYAAFIAASEALSFVRAQLEGFDKHLEALVEEIPNLTSGCTEFVESAHQILEER 182
           + +  ENY  FI+A++ +  ++      +  ++ L   +  +T    +F       L++R
Sbjct: 105 QTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVIT----DFSARISATLQDR 160

Query: 183 KLNQTLLANHSTLLD----LLEIPQLMDTCIRNGNYDEALDLEAFVSKISKLHPDLPVIQ 350
               T LA    LL     L E+P  +  C+  G Y +A+  +     + + +  LP  +
Sbjct: 161 HERITKLAGVHALLRKLQFLFELPSRLTKCVELGAYGQAVRYQGRAQAVLQQYQHLPSFR 220

Query: 351 GL 356
            +
Sbjct: 221 AI 222

>TOP2A_CHICK (O42130) DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase|
           II, alpha isozyme)
          Length = 1553

 Score = 32.0 bits (71), Expect = 1.9
 Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 4/49 (8%)
 Frame = +3

Query: 516 REAWLSGILDDLDQRNVY----DYLKGMVTCHRTHLFDVVNQYRAIFNN 650
           R+ WL+  ++D  QRNV+    DYL G  T + T+  D +N+   +F+N
Sbjct: 662 RKEWLTNFMEDRRQRNVHGLPEDYLYGKDTNYLTY-NDFINKELVLFSN 709

>GIMA4_RAT (Q8K3K9) GTPase, IMAP family member 4 (Immunity-associated protein|
           4) (Immunity-associated nucleotide 1 protein)
          Length = 310

 Score = 29.6 bits (65), Expect = 9.4
 Identities = 13/43 (30%), Positives = 27/43 (62%)
 Frame = +3

Query: 543 DDLDQRNVYDYLKGMVTCHRTHLFDVVNQYRAIFNNDKSGSEE 671
           DDL+  ++++YL+      +  +++  N+Y  +FNN  SG+E+
Sbjct: 157 DDLEDTDIHEYLETAPEVLQELIYEFRNRY-CLFNNKASGAEQ 198


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,112,873
Number of Sequences: 219361
Number of extensions: 1886273
Number of successful extensions: 4908
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 4775
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4907
length of database: 80,573,946
effective HSP length: 109
effective length of database: 56,663,597
effective search space used: 7139613222
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)