>HMT3_MAIZE (Q9FUM8) Homocysteine S-methyltransferase 3 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 3)
           (SMM:Hcy S-methyltransferase 3) (ZmHMT-3)
          Length = 338

 Score =  319 bits (817), Expect = 5e-87
 Identities = 154/166 (92%), Positives = 158/166 (95%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRRLQVLAEA PDLIAFETIPNKLEAQAYVELL+ECNINIPSW SFNSKDGV+VVSGD
Sbjct: 163 FHRRRLQVLAEAGPDLIAFETIPNKLEAQAYVELLEECNINIPSWLSFNSKDGVHVVSGD 222

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           SLIECA IA+ CAKVGAVGINCTPPRFIH LILSIRKVTDKPILIYPNSGERYD EKKEW
Sbjct: 223 SLIECATIADKCAKVGAVGINCTPPRFIHGLILSIRKVTDKPILIYPNSGERYDGEKKEW 282

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQ 509
           VESTGVSDGDFVSYV EWCKDGAALIGGCCRTTPNTIRAI R+LNQ
Sbjct: 283 VESTGVSDGDFVSYVNEWCKDGAALIGGCCRTTPNTIRAIHRTLNQ 328

>HMT2_MAIZE (Q9FUM9) Homocysteine S-methyltransferase 2 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 2)
           (SMM:Hcy S-methyltransferase 2) (ZmHMT-2)
          Length = 339

 Score =  314 bits (804), Expect = 2e-85
 Identities = 149/166 (89%), Positives = 157/166 (94%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRRLQVLAEA PDLIAFETIPNKLEA+AYVELL+ECNINIP+WFSFNSKDGV++VSGD
Sbjct: 163 FHRRRLQVLAEAGPDLIAFETIPNKLEAEAYVELLEECNINIPAWFSFNSKDGVHIVSGD 222

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           SLIEC  IA+ CAKVGAVGINCTPPRFIH LILSIRKVTDKPILIYPNSGERYD EKKEW
Sbjct: 223 SLIECTTIADKCAKVGAVGINCTPPRFIHGLILSIRKVTDKPILIYPNSGERYDGEKKEW 282

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQ 509
           VESTGVSDGDFVSYV EWCKDGA LIGGCCRTTPNTIRAI R+LN+
Sbjct: 283 VESTGVSDGDFVSYVNEWCKDGAVLIGGCCRTTPNTIRAIHRTLNK 328

>HMT2_ARATH (Q9M1W4) Homocysteine S-methyltransferase 2 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 2)
           (SMM:Hcy S-methyltransferase 2) (AtHMT-2)
          Length = 333

 Score =  250 bits (638), Expect = 3e-66
 Identities = 118/164 (71%), Positives = 136/164 (82%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRRLQVLAE+  DLIAFETIPNK+EAQA+ +LL+E ++ IP WFSFNSKDGVNVVSGD
Sbjct: 164 FHRRRLQVLAESGADLIAFETIPNKIEAQAFADLLEEGDVKIPGWFSFNSKDGVNVVSGD 223

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           S+ EC +IA  C KV AVGINCTPPRFI  L+L I KVT KPIL+YPNSGE YDA++KEW
Sbjct: 224 SIKECISIAENCEKVVAVGINCTPPRFIEGLVLEIEKVTSKPILVYPNSGESYDADRKEW 283

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSL 503
           VE+TGV D DFVSYV +W   G +L+GGCCRTTP TIRAI + L
Sbjct: 284 VENTGVGDEDFVSYVEKWMDAGVSLLGGCCRTTPTTIRAIHKRL 327

>SMTA_ASTBI (P56707) Selenocysteine methyltransferase (EC 2.1.1.-)|
           (SECYS-methyltransferase) (SECYS-MT)
          Length = 338

 Score =  239 bits (611), Expect = 4e-63
 Identities = 110/165 (66%), Positives = 139/165 (84%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRR++Q+LA++  DL+AFE +PNKLEAQAY +LL+E NI  P+WF+F SKDG NVVSGD
Sbjct: 164 FHRRKVQILADSGVDLLAFEAVPNKLEAQAYADLLEEENIITPAWFAFTSKDGNNVVSGD 223

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           S+ EC +IA +C KV AVGINCTPPRFIH LIL ++KVT KPI+IYPNSGE YDA +KEW
Sbjct: 224 SIEECGSIAESCDKVVAVGINCTPPRFIHDLILLLKKVTAKPIVIYPNSGETYDAIRKEW 283

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLN 506
            +++GV+D DFVSYV +WC+ GA+L+GGCCRTTP+TIR I + L+
Sbjct: 284 GQNSGVTDEDFVSYVDKWCESGASLVGGCCRTTPDTIRGIYKILS 328

>HMT4_MAIZE (Q9FUM7) Homocysteine S-methyltransferase 4 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 4)
           (SMM:Hcy S-methyltransferase 4) (ZmHMT-4)
          Length = 342

 Score =  238 bits (607), Expect = 1e-62
 Identities = 115/167 (68%), Positives = 135/167 (80%), Gaps = 1/167 (0%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRRLQVLA A PDLIAFETIPNKLEAQ Y ELL+E  I IP+WFSF SKDGVN  SGD
Sbjct: 164 FHRRRLQVLAGAGPDLIAFETIPNKLEAQVYAELLEENGIRIPAWFSFTSKDGVNAASGD 223

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
            + ECA +A++C +V AVG+NCT PRFIH LILSI+KVT KPI++YPNSGE Y AE  EW
Sbjct: 224 PINECAAVADSCPRVDAVGVNCTAPRFIHGLILSIKKVTSKPIVVYPNSGETYVAETNEW 283

Query: 372 VESTGVS-DGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQ 509
           V+S G +   DFVS VGEW + GAALIGGCCRT+P T+RAI+R++ +
Sbjct: 284 VDSDGATGTDDFVSRVGEWRRAGAALIGGCCRTSPATVRAIARAVRE 330

>HMT3_ARATH (Q8LAX0) Homocysteine S-methyltransferase 3 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 3)
           (SMM:Hcy S-methyltransferase 3) (AtHMT-3)
          Length = 347

 Score =  232 bits (592), Expect = 6e-61
 Identities = 107/171 (62%), Positives = 141/171 (82%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRR+Q+LA++  DLIAFETIPNKLEA+AY +LL+E +I+IP+WFSF SKDGV+V  GD
Sbjct: 170 FHRRRVQILAKSGADLIAFETIPNKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGD 229

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           S++ECA +A++C  V A+GINCT PR+IH+LI+S+R++T KPI++YPNSGE YD   K+W
Sbjct: 230 SVVECAKVADSCKNVVAIGINCTAPRYIHALIISLRQMTRKPIVVYPNSGEVYDGLNKKW 289

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQYYPAA 524
           ++S G S+ DFVSYV +W   GA+L GGCCRTTPNTIRAI++ L+    AA
Sbjct: 290 IKSEGESEEDFVSYVSKWRDAGASLFGGCCRTTPNTIRAIAKVLSDEPSAA 340

>HMT1_MAIZE (Q9FUN0) Homocysteine S-methyltransferase 1 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 1)
           (SMM:Hcy S-methyltransferase 1) (ZmHMT-1)
          Length = 323

 Score =  191 bits (484), Expect = 2e-48
 Identities = 92/164 (56%), Positives = 113/164 (68%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRRLQVLA A PDLIAFE IPN++EAQA VELL+E  + IPSW  F+S DG N+ SG+
Sbjct: 154 FHRRRLQVLASAGPDLIAFEAIPNQMEAQALVELLEEEKVQIPSWICFSSVDGKNLCSGE 213

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           S  +C  I NA  KV  VG+NCTPP+FI  +I   RK T K I +YPNSGE +D   K W
Sbjct: 214 SFADCLKILNASEKVAVVGVNCTPPQFIEGIICEFRKQTKKAIAVYPNSGEVWDGRAKRW 273

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSL 503
           +    +    F +    W + GA+LIGGCCRTTP+TIRA+S+ L
Sbjct: 274 LPVECLGHKSFDALAKRWQEAGASLIGGCCRTTPSTIRAVSKIL 317

>HMT1_ARATH (Q9SDL7) Homocysteine S-methyltransferase 1 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 1)
           (SMM:Hcy S-methyltransferase 1) (AtHMT-1)
          Length = 326

 Score =  188 bits (478), Expect = 1e-47
 Identities = 93/166 (56%), Positives = 113/166 (68%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FHRRRLQVL EA PDL+AFETIPNKLEAQA VELL+E  + IP+W  F S DG    SG+
Sbjct: 160 FHRRRLQVLVEAGPDLLAFETIPNKLEAQACVELLEEEKVQIPAWICFTSVDGEKAPSGE 219

Query: 192 SLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEW 371
           S  EC    N    + AVGINC PP+FI +LI    K+T K I++YPNSGE +D + K+W
Sbjct: 220 SFEECLEPLNKSNNIYAVGINCAPPQFIENLIRKFAKLTKKAIVVYPNSGEVWDGKAKQW 279

Query: 372 VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQ 509
           + S    D +F  +  +W   GA LIGGCCRTTP+TI AISR L +
Sbjct: 280 LPSQCFGDDEFEMFATKWRDLGAKLIGGCCRTTPSTINAISRDLKR 325

>MMUM_ECOLI (Q47690) Homocysteine S-methyltransferase (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase)
          Length = 310

 Score =  109 bits (272), Expect = 8e-24
 Identities = 61/162 (37%), Positives = 86/162 (53%)
 Frame = +3

Query: 6   EXFHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVS 185
           + FHR R++ L +A  DL+A ET+PN  E +A  ELL        +WFSF  +D  ++  
Sbjct: 147 QAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP-RARAWFSFTLRDSEHLSD 205

Query: 186 GDSLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKK 365
           G  L +   +     +V A+GINC       + +  +  +T  P+++YPNSGE YDA  K
Sbjct: 206 GTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSK 265

Query: 366 EWVESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAI 491
            W    G        Y+ +W   GA LIGGCCRTTP  I A+
Sbjct: 266 TW-HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306

>MHT1_YEAST (Q12525) Homocysteine S-methyltransferase 1 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 1)
           (SMM:Hcy S-methyltransferase 1)
          Length = 324

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 57/161 (35%), Positives = 88/161 (54%), Gaps = 8/161 (4%)
 Frame = +3

Query: 54  DLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGDSLIECA----NIAN 221
           DLI FETIPN  E +A +   DE  I+ P +   +  D   +  G +L E +     + N
Sbjct: 167 DLIGFETIPNFHELKAILSW-DEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGN 225

Query: 222 ACAK-VGAVGINCTPPRFIHS-LILSI--RKVTDKPILIYPNSGERYDAEKKEWVESTGV 389
              K +  +G+NC    F  S LIL +    +   P+L+YPNSGE Y+ ++K W   T  
Sbjct: 226 KINKNLLLMGVNCVS--FNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNK 283

Query: 390 SDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQY 512
            D D+ + V ++  +GA +IGGCCRT+P  I  I+ ++++Y
Sbjct: 284 LD-DWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKY 323

>SAM4_YEAST (Q08985) Homocysteine S-methyltransferase 2 (EC 2.1.1.10)|
           (S-methylmethionine:homocysteine methyltransferase 2)
           (SMM:Hcy S-methyltransferase 2) (S-adenosylmethionine
           metabolism protein 4)
          Length = 325

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 53/160 (33%), Positives = 83/160 (51%), Gaps = 7/160 (4%)
 Frame = +3

Query: 54  DLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGDSLIECANIANACA- 230
           DLI FETIPN  E +A +   DE  ++ P +   +  +   +  G ++ E A +      
Sbjct: 168 DLIGFETIPNIHELKAILSW-DESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGD 226

Query: 231 ----KVGAVGINCTPPRFIHSLILSIRK-VTDKPILIYPNSGERYDAEKKEWV-ESTGVS 392
                   +GINC        ++ S+ + + +  +L YPNSGE YD EKK W+  S  ++
Sbjct: 227 KINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLN 286

Query: 393 DGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSLNQY 512
             D V  V ++   GA +IGGCCRT+P  I+ IS ++ +Y
Sbjct: 287 SWDTV--VKQYISSGARIIGGCCRTSPKDIQEISAAVKKY 324

>YM99_YEAST (Q04898) Hypothetical protein YMR321c|
          Length = 105

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 36/92 (39%), Positives = 55/92 (59%), Gaps = 2/92 (2%)
 Frame = +3

Query: 243 VGINCTPPRFIHSLILSIRK-VTDKPILIYPNSGERYDAEKKEWV-ESTGVSDGDFVSYV 416
           +GINC        ++ S+ + + +  +L YPNSGE YD EKK W+  S  ++  D V  V
Sbjct: 15  LGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTV--V 72

Query: 417 GEWCKDGAALIGGCCRTTPNTIRAISRSLNQY 512
            ++   GA +IGGCCRT+P  I+ IS ++ +Y
Sbjct: 73  KQYISSGARIIGGCCRTSPKDIQEISAAVKKY 104

>METH_VIBCH (Q9KUW9) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 45/176 (25%), Positives = 74/176 (42%), Gaps = 11/176 (6%)
 Frame = +3

Query: 30  QVLAEARPDLIAFETIPNKLEAQAYVELLD----ECNINIPSWFSFNSKDGVNVVSGDSL 197
           + L +   DLI  ETI + L A+A    +D    E  I++P   S    D          
Sbjct: 169 RALIKGGSDLILIETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQT 228

Query: 198 IECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAE 359
            E    A    +  + G+NC   P  +   +  + ++++  +  +PN+G       YD  
Sbjct: 229 TEAFYNALRHVRPISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLS 288

Query: 360 KKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYPAA 524
            +E  E           ++ EW + G   L+GGCC TTP  I AI++++    P A
Sbjct: 289 AEEMAE-----------HIAEWAQAGFLNLVGGCCGTTPEHIAAIAKAVEGVKPRA 333

>METH_VIBF1 (Q5E814) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 44/166 (26%), Positives = 67/166 (40%), Gaps = 11/166 (6%)
 Frame = +3

Query: 30  QVLAEARPDLIAFETIPNKLEAQA----YVELLDECNINIPSWFSFNSKDGVNVVSGDSL 197
           + L     DLI  ETI + L A+A       + +E +I +P   S    D          
Sbjct: 170 RALIRGGSDLILIETIFDTLNAKACSFAVESVFEELDITLPVMISGTITDASGRTLSGQT 229

Query: 198 IECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAE 359
            E    A    K  + G+NC   P  +   +  + ++++  +  +PN+G       YD  
Sbjct: 230 TEAFYNALRHVKPISFGLNCALGPDELREYVSDLSRISECYVSAHPNAGLPNAFGEYD-- 287

Query: 360 KKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAIS 494
                    +S  D   +V EW   G   LIGGCC TTP  IR ++
Sbjct: 288 ---------LSPEDMAEHVAEWASSGFLNLIGGCCGTTPEHIRQMA 324

>METH_VIBFI (Q9AJQ8) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 44/166 (26%), Positives = 66/166 (39%), Gaps = 11/166 (6%)
 Frame = +3

Query: 30  QVLAEARPDLIAFETIPNKLEAQA----YVELLDECNINIPSWFSFNSKDGVNVVSGDSL 197
           + L     DLI  ETI + L A+A       + +E  I +P   S    D          
Sbjct: 170 RALIRGGSDLILIETIFDTLNAKACSFAVESVFEELGITLPVMISGTITDASGRTLSGQT 229

Query: 198 IECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAE 359
            E    A    K  + G+NC   P  +   +  + ++++  +  +PN+G       YD  
Sbjct: 230 TEAFYNALRHVKPISFGLNCALGPDELREYVSELSRISECYVSAHPNAGLPNAFGEYD-- 287

Query: 360 KKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAIS 494
                    +S  D   +V EW   G   LIGGCC TTP  IR ++
Sbjct: 288 ---------LSPEDMAEHVAEWASSGFLNLIGGCCGTTPEHIRQMA 324

>METH_SALTY (P37586) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 42/179 (23%), Positives = 72/179 (40%), Gaps = 11/179 (6%)
 Frame = +3

Query: 15  HRRRLQVLAEARPDLIAFETIPNKLEAQAYV----ELLDECNINIPSWFSFNSKDGVNVV 182
           +R   + L E   DLI  ET+ + L A+A V    E  +   +++P   S    D     
Sbjct: 162 YRESTKALVEGGADLILIETVFDTLNAKAAVFAVKEEFEALGVDLPIMISGTITDASGRT 221

Query: 183 SGDSLIECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----E 344
                 E    +   A+    G+NC   P  +   +  + ++ +  +  +PN+G      
Sbjct: 222 LSGQTTEAFYNSLRHAEALTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFG 281

Query: 345 RYDAEKKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYP 518
            YD +     +            + EW + G   ++GGCC TTP  I A+SR++    P
Sbjct: 282 EYDLDADTMAKQ-----------IREWAEAGFLNIVGGCCGTTPEHIAAMSRAVAGLLP 329

>METH_VIBPA (Q87L95) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/176 (25%), Positives = 71/176 (40%), Gaps = 11/176 (6%)
 Frame = +3

Query: 30  QVLAEARPDLIAFETIPNKLEAQAYVELLD----ECNINIPSWFSFNSKDGVNVVSGDSL 197
           + L     DLI  ETI + L A+A    +D    E  + +P   S    D          
Sbjct: 169 RALIRGGADLILIETIFDTLNAKACAFAVDSVFEELGVALPVMISGTITDASGRTLSGQT 228

Query: 198 IECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAE 359
            E    +    +  + G+NC   P  +   +  + ++++  +  +PN+G       YD  
Sbjct: 229 TEAFYNSLRHVRPLSFGLNCALGPDELRPYVEELSRISESFVSAHPNAGLPNAFGEYD-- 286

Query: 360 KKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYPAA 524
                    +S  D   +V EW   G   LIGGCC TTP  IR +++++    P A
Sbjct: 287 ---------LSPEDMAEHVKEWASSGFLNLIGGCCGTTPEHIRQMAQAVEGVTPRA 333

>METH_ECOLI (P13009) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase,
           vitamin-B12-dependent isozyme) (MS)
          Length = 1226

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 41/179 (22%), Positives = 71/179 (39%), Gaps = 11/179 (6%)
 Frame = +3

Query: 15  HRRRLQVLAEARPDLIAFETIPNKLEAQAYVELL----DECNINIPSWFSFNSKDGVNVV 182
           +R   + L E   DLI  ET+ + L A+A V  +    +   + +P   S    D     
Sbjct: 162 YRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRT 221

Query: 183 SGDSLIECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----E 344
                 E    +   A+    G+NC   P  +   +  + ++ +  +  +PN+G      
Sbjct: 222 LSGQTTEAFYNSLRHAEALTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFG 281

Query: 345 RYDAEKKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYP 518
            YD +     +            + EW + G   ++GGCC TTP  I A+SR++    P
Sbjct: 282 EYDLDADTMAKQ-----------IREWAQAGFLNIVGGCCGTTPQHIAAMSRAVEGLAP 329

>METH_PSEPU (O33465) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS) (Fragment)
          Length = 607

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 47/184 (25%), Positives = 75/184 (40%), Gaps = 11/184 (5%)
 Frame = +3

Query: 36  LAEARPDLIAFETIPNKLEAQAYV----ELLDECNINIPSWFSFNSKDGVNVVSGDSLIE 203
           L E   DLI  ETI + L A+A +    ++ +E  + +P   S    D           E
Sbjct: 173 LIEGGADLILIETIFDTLNAKAAIFAVQQVFEEDAVELPIMISGTITDASGRTLSGQTTE 232

Query: 204 CANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAEKK 365
               +   AK  +VG+NC    + +   +  +    D  +  +PN+G       YD    
Sbjct: 233 AFWNSVRHAKPISVGLNCALGAKDLRPYLEELSTKADTHVSAHPNAGLPNAFGEYDETPA 292

Query: 366 EWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYPAA*VFAAQ 542
           E             + V E+   G   +IGGC  TTP  I+AI+ ++ +Y P      A+
Sbjct: 293 E-----------MAAVVEEFAASGFLNIIGGCSGTTPGHIQAIAEAVAKYKPREIPEIAK 341

Query: 543 SCTL 554
           +C L
Sbjct: 342 ACRL 345

>METH_VIBVU (Q8DCJ7) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 11/174 (6%)
 Frame = +3

Query: 30  QVLAEARPDLIAFETIPNKLEAQAYVELLD----ECNINIPSWFSFNSKDGVNVVSGDSL 197
           + L     DLI  ETI + L A+A    +D    E    +P   S    D          
Sbjct: 169 RALIRGGSDLILIETIFDTLNAKACAFAVDSVFEELGFALPVMISGTITDASGRTLSGQT 228

Query: 198 IECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAE 359
            E    +    +  + G+NC   P  +   +  + ++++  +  +PN+G       YD  
Sbjct: 229 TEAFYNSLRHVRPISFGLNCALGPDELRPYVEELSRISETFVSTHPNAGLPNAFGEYDLS 288

Query: 360 KKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYP 518
            +E  E           +V EW + G   LIGGCC TTP  IR ++ ++    P
Sbjct: 289 PEEMAE-----------HVKEWAQSGFLNLIGGCCGTTPEHIRHMAMAVEGVSP 331

>METH_VIBVY (Q7MHB1) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1226

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 11/174 (6%)
 Frame = +3

Query: 30  QVLAEARPDLIAFETIPNKLEAQAYV----ELLDECNINIPSWFSFNSKDGVNVVSGDSL 197
           + L     DLI  ETI + L A+A       + +E    +P   S    D          
Sbjct: 169 RALIRGGSDLILIETIFDTLNAKACAFAVESVFEELGFALPVMISGTITDASGRTLSGQT 228

Query: 198 IECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAE 359
            E    +    +  + G+NC   P  +   +  + ++++  +  +PN+G       YD  
Sbjct: 229 TEAFYNSLRHVRPISFGLNCALGPDELRPYVEELSRISETFVSTHPNAGLPNAFGEYDLS 288

Query: 360 KKEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYP 518
            +E  E           +V EW + G   LIGGCC TTP  IR ++ ++    P
Sbjct: 289 PEEMAE-----------HVKEWAQSGFLNLIGGCCGTTPEHIRHMAMAVEGESP 331

>METH_CAEEL (Q09582) Probable methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent) (MS)
          Length = 1249

 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 42/173 (24%), Positives = 74/173 (42%), Gaps = 12/173 (6%)
 Frame = +3

Query: 36  LAEARPDLIAFETIPNKLEAQAYVELL-----DECNINIPSWFSFNSKDGVNVVSGDSLI 200
           L +   D++  ET+ +   A+A +  +     DE    +P + S    D           
Sbjct: 171 LIQGGVDVLLVETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTG 230

Query: 201 ECANIANACAKVGAVGINCT-PPRFIHSLILSIRKVTDKPILIYPNSG-----ERYDAEK 362
           E   ++    K  AVG+NC    + +   + ++ K +D  I+ YPN+G       YD   
Sbjct: 231 EAFLVSTKQGKPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETP 290

Query: 363 KEWVESTGVSDGDFVSYVGEWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYP 518
           +E  +            + E+ +DG   +IGGCC TTP+ I A+ +++    P
Sbjct: 291 EEMAD-----------VLREFARDGLVNIIGGCCGTTPDHINAMYKAVQGITP 332

>METH_MYCLE (Q49775) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1206

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 39/163 (23%), Positives = 70/163 (42%), Gaps = 13/163 (7%)
 Frame = +3

Query: 54  DLIAFETIPNKLEAQAYV----ELLDECNINIPSWFSFNSKDGVNVVSGDSLIECANIAN 221
           D +  ET  + L+ +A V      + +   +IP +     +    ++ G S I  A  A 
Sbjct: 163 DAVLVETCQDLLQLKAAVLGSRRAMTQAGRHIPVFVHVTVETTGTMLLG-SEIGAALAAV 221

Query: 222 ACAKVGAVGINC-TPPRFIHSLILSIRKVTDKPILIYPNSG--------ERYDAEKKEWV 374
               V  +G+NC T P  +   +  + K    P+ + PN+G          Y  +  E  
Sbjct: 222 EPLGVDMIGLNCATGPAEMSEHLRHLSKHARIPVSVMPNAGLPVLGAKGAEYPLQPDELA 281

Query: 375 ESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSL 503
           E+          ++ E+   G +L+GGCC TTP+ IR ++ ++
Sbjct: 282 EA-------LAGFIAEF---GLSLVGGCCGTTPDHIREVAAAV 314

>YDM7_SCHPO (P87138) Hypothetical protein C57A7.07c in chromosome I|
          Length = 308

 Score = 38.9 bits (89), Expect = 0.013
 Identities = 41/177 (23%), Positives = 74/177 (41%), Gaps = 22/177 (12%)
 Frame = +3

Query: 12  FHRRRLQVLAEARP------DLIAFETIPNKLEAQAYVELLDECN-INIPSWFSFNSKDG 170
           FH+ R++ +  + P      D IAFE++P+  EA+   +L+ +    +   W +    + 
Sbjct: 130 FHKNRIEAIQASNPKAFEKIDFIAFESLPHVTEAEVVCQLIQDMKGWSKRCWITCTCPER 189

Query: 171 VNVVSGDSLIECANIANACAKVGAVGINCTPPRFIHSLILSIRKVTDKPI------LIYP 332
             +    S+I      N  + +  +G+NC    F  SL+  I K+    +      ++YP
Sbjct: 190 STIERVSSIISKILSINHDS-IWGIGVNC----FHLSLLEPIAKMLSSLLPSNITAILYP 244

Query: 333 NSGERYDAEKKEWVESTGVSDGDFVSYVGEWCK---------DGAALIGGCCRTTPN 476
           +    Y  +  +   S G +D    S   EW           +G  ++GGCC T  N
Sbjct: 245 DGRGLY--QNPDGTFSPGSTDHPAPS-PEEWSTITAKYSNLHNGNLILGGCCETNYN 298

>METH_MYCTU (O33259) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent isozyme) (MS)
          Length = 1192

 Score = 35.8 bits (81), Expect = 0.11
 Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 1/91 (1%)
 Frame = +3

Query: 234 VGAVGINC-TPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEWVESTGVSDGDFVS 410
           V  +G+NC T P  +   +  + +    P+ + PN+G      K    E   + D    +
Sbjct: 224 VDMIGLNCATGPAEMSEHLRHLSRHARIPVSVMPNAGLPVLGAKG--AEYPLLPDELAEA 281

Query: 411 YVGEWCKDGAALIGGCCRTTPNTIRAISRSL 503
             G   + G +L+GGCC TTP  IR ++ ++
Sbjct: 282 LAGFIAEFGLSLVGGCCGTTPAHIREVAAAV 312

>METH_HUMAN (Q99707) Methionine synthase (EC 2.1.1.13)|
           (5-methyltetrahydrofolate--homocysteine
           methyltransferase) (Methionine synthase, vitamin-B12
           dependent) (MS)
          Length = 1265

 Score = 35.0 bits (79), Expect = 0.19
 Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 2/94 (2%)
 Frame = +3

Query: 243 VGINCT-PPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEWVESTGVSDGDFVSYVG 419
           +G+NC      +   I  I K T   +L YPN+G        +   S          ++ 
Sbjct: 256 IGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSM------MAKHLK 309

Query: 420 EWCKDGAA-LIGGCCRTTPNTIRAISRSLNQYYP 518
           ++  DG   ++GGCC +TP+ IR I+ ++    P
Sbjct: 310 DFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKP 343

>BHMT_RAT (O09171) Betaine--homocysteine S-methyltransferase (EC 2.1.1.5)|
          Length = 407

 Score = 31.2 bits (69), Expect = 2.7
 Identities = 44/179 (24%), Positives = 69/179 (38%), Gaps = 15/179 (8%)
 Frame = +3

Query: 12  FHRRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGD 191
           FH++ L+V  +   D +  E   +  EA   VE L      I +      +  ++ VS  
Sbjct: 141 FHQQ-LEVFMKKNVDFLIAEYFEHVEEAVWAVEALKTSGKPIAATMCIGPEGDLHGVSPG 199

Query: 192 SLIECANIANACAKVGAVGINC--TPPRFIHSLILSIRKVTDKPILIY----------PN 335
              ECA +    A    VG+NC   P   + ++ L    +    +  Y          P+
Sbjct: 200 ---ECA-VRLVKAGAAIVGVNCHFDPSTSLQTIKLMKEGLEAARLKAYLMSHALAYHTPD 255

Query: 336 SGERYDAEKKEW---VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSL 503
            G++   +  E+   +E    +  D   Y  E    G   IGGCC   P  IRAI+  L
Sbjct: 256 CGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEEL 314

>STEA2_MOUSE (Q8BWB6) Six-transmembrane epithelial antigen of prostate 2|
          Length = 489

 Score = 30.4 bits (67), Expect = 4.6
 Identities = 15/47 (31%), Positives = 24/47 (51%)
 Frame = +3

Query: 258 TPPRFIHSLILSIRKVTDKPILIYPNSGERYDAEKKEWVESTGVSDG 398
           TPP F+ +L+L    +  K IL+ P    +    KK W +S  + +G
Sbjct: 427 TPPNFVLALVLPSIVILGKMILLLPCISRKLKRIKKGWEKSQFLDEG 473

>BHMT_MOUSE (O35490) Betaine--homocysteine S-methyltransferase (EC 2.1.1.5)|
          Length = 407

 Score = 30.0 bits (66), Expect = 6.0
 Identities = 40/177 (22%), Positives = 68/177 (38%), Gaps = 15/177 (8%)
 Frame = +3

Query: 18  RRRLQVLAEARPDLIAFETIPNKLEAQAYVELLDECNINIPSWFSFNSKDGVNVVSGDSL 197
           R++L+V  +   D +  E   +  EA   VE L      + +      +  ++ V     
Sbjct: 142 RQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVPPG-- 199

Query: 198 IECANIANACAKVGAVGINCTPPRFIHSLILSIRK-----------VTDKPILIY-PNSG 341
            ECA +    A    VG+NC     +    + + K           +  +P+  + P+ G
Sbjct: 200 -ECA-VRLVKAGASIVGVNCHFDPSVSLQTVKLMKEGLEAARLKAYLMSQPLAYHTPDCG 257

Query: 342 ERYDAEKKEW---VESTGVSDGDFVSYVGEWCKDGAALIGGCCRTTPNTIRAISRSL 503
           ++   +  E+   +E    +  D   Y  E    G   IGGCC   P  IRAI+  L
Sbjct: 258 KQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEEL 314

>YA4C_SCHPO (Q09729) Hypothetical protein C31A2.12 in chromosome I|
          Length = 596

 Score = 30.0 bits (66), Expect = 6.0
 Identities = 16/39 (41%), Positives = 21/39 (53%)
 Frame = -2

Query: 454 PPIRAAPSLHHSPT*ETKSPSDTPVDSTHSFFSASYLSP 338
           PP R +PS   SPT  T+   D+     HS  S+S +SP
Sbjct: 503 PPQRTSPSFFVSPTESTRQSLDSRRSFEHSTSSSSGISP 541

>SYM_ACIAD (Q6FE36) Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA|
           ligase) (MetRS)
          Length = 685

 Score = 29.6 bits (65), Expect = 7.9
 Identities = 22/89 (24%), Positives = 34/89 (38%), Gaps = 17/89 (19%)
 Frame = +3

Query: 156 NSKDGVNVVSGDSLIECANIANACAKV------GAVGINCTPPRFIHSLILSIRKVTD-- 311
           N  D V  V+ D + +  NIA+ CAK         +  NC  P  + S I +   +    
Sbjct: 371 NLDDFVQKVNSDLVGKVVNIASRCAKFINSSFNNTLSANCAEPELVQSFIDAGDSIAQAY 430

Query: 312 ---------KPILIYPNSGERYDAEKKEW 371
                    + I+   +   +Y  EKK W
Sbjct: 431 EAREFSAAIREIMALADKANQYIDEKKPW 459


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,749,900
Number of Sequences: 219361
Number of extensions: 1987226
Number of successful extensions: 6001
Number of sequences better than 10.0: 31
Number of HSP's better than 10.0 without gapping: 5735
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5985
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5938641176
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)