ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags16i12 |
|---|---|
| Clone Library Name | barley_pub |
>WNK3_HUMAN (Q9BYP7) Serine/threonine-protein kinase WNK3 (EC 2.7.11.1)| (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) Length = 1743 Score = 198 bits (504), Expect = 1e-50 Identities = 96/193 (49%), Positives = 132/193 (68%), Gaps = 1/193 (0%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 +++ + + ++TEL TSG+L+ + K+ + K +R W QIL GL++LH++ P IIHRD Sbjct: 216 ILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRD 275 Query: 184 LKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFG 363 LKCDNIFI G G VKIGD GLAT + +S+ GT EFMAPE++ +Y+E VD+Y+FG Sbjct: 276 LKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFG 335 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLC 540 MCMLEM T EYPYSECQ IY+K++ GIKP +KV D EV+ IE C+ +ERL Sbjct: 336 MCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLS 395 Query: 541 ASELLKNCFLQKD 579 +LL + F +D Sbjct: 396 IRDLLNHAFFAED 408
>WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 189 bits (481), Expect = 5e-48 Identities = 92/192 (47%), Positives = 127/192 (66%), Gaps = 1/192 (0%) Frame = +1 Query: 7 MRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDL 186 ++ + + ++TEL TSG+L+ + K+ + +K +R W QIL GL++LH++ P IIHRDL Sbjct: 291 VKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDL 350 Query: 187 KCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFGM 366 KCDNIFI G G VKIGD GLAT +S+ GT EFMAPE++ Y+E VD+Y+FGM Sbjct: 351 KCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGM 410 Query: 367 CMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLCA 543 CMLEM T EYPYSECQ IY++++ G+KP KV EV+ IE C+ ER Sbjct: 411 CMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSI 470 Query: 544 SELLKNCFLQKD 579 +LL + F Q++ Sbjct: 471 KDLLNHAFFQEE 482
>WNK1_MOUSE (P83741) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2377 Score = 189 bits (481), Expect = 5e-48 Identities = 92/192 (47%), Positives = 127/192 (66%), Gaps = 1/192 (0%) Frame = +1 Query: 7 MRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDL 186 ++ + + ++TEL TSG+L+ + K+ + +K +R W QIL GL++LH++ P IIHRDL Sbjct: 291 VKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDL 350 Query: 187 KCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFGM 366 KCDNIFI G G VKIGD GLAT +S+ GT EFMAPE++ Y+E VD+Y+FGM Sbjct: 351 KCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGM 410 Query: 367 CMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLCA 543 CMLEM T EYPYSECQ IY++++ G+KP KV EV+ IE C+ ER Sbjct: 411 CMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSI 470 Query: 544 SELLKNCFLQKD 579 +LL + F Q++ Sbjct: 471 KDLLNHAFFQEE 482
>WNK1_RAT (Q9JIH7) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2126 Score = 189 bits (481), Expect = 5e-48 Identities = 92/192 (47%), Positives = 127/192 (66%), Gaps = 1/192 (0%) Frame = +1 Query: 7 MRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDL 186 ++ + + ++TEL TSG+L+ + K+ + +K +R W QIL GL++LH++ P IIHRDL Sbjct: 291 VKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDL 350 Query: 187 KCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFGM 366 KCDNIFI G G VKIGD GLAT +S+ GT EFMAPE++ Y+E VD+Y+FGM Sbjct: 351 KCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGM 410 Query: 367 CMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLCA 543 CMLEM T EYPYSECQ IY++++ G+KP KV EV+ IE C+ ER Sbjct: 411 CMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSI 470 Query: 544 SELLKNCFLQKD 579 +LL + F Q++ Sbjct: 471 KDLLNHAFFQEE 482
>PKPA_PHYBL (Q01577) Serine/threonine-protein kinase pkpA (EC 2.7.11.1)| Length = 613 Score = 189 bits (479), Expect = 8e-48 Identities = 96/181 (53%), Positives = 126/181 (69%), Gaps = 2/181 (1%) Frame = +1 Query: 34 ITELCTSGSLRQFRKKHNKV-GMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ITEL TSG+LR++ +K + +K ++ W QIL GL YLH EP IIHRD+KCDNIFIN Sbjct: 90 ITELMTSGTLREYIRKLTPLPNIKIVKRWCRQILKGLAYLHGHEPPIIHRDIKCDNIFIN 149 Query: 211 GHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMVT 387 G G++KIGD G A + +K I GT EFMAPE++ YNE VDIY+FGMC+LEM T Sbjct: 150 GAHGEIKIGDMGTAEMKNGKKYTVI-GTPEFMAPEMYEEQGYNEKVDIYAFGMCLLEMAT 208 Query: 388 CEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLCASELLKNCF 567 EYPY EC ++KK++Q IKP+ LS+V+D E+ + ICL P ER+ A E+L++ F Sbjct: 209 GEYPYGECTNAVQVFKKVTQTIKPECLSRVQDPELLTLVNICLTPEDERMTAQEILEHRF 268 Query: 568 L 570 L Sbjct: 269 L 269
>WNK4_RAT (Q7TPK6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 187 bits (475), Expect = 2e-47 Identities = 89/194 (45%), Positives = 130/194 (67%), Gaps = 1/194 (0%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 ++R + + ++TEL TSG+L+ + ++ ++ + ++ W+ QIL GL +LHS+ P I+HRD Sbjct: 240 VLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRD 299 Query: 184 LKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFG 363 LKCDN+FI G G VKIGD GLAT +S+ GT EFMAPE++ Y+E VD+Y+FG Sbjct: 300 LKCDNVFITGPSGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFG 359 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-APVTERLC 540 MCMLEM T EYPYSECQ IY+K++ G KP+ KV+ EV+ IE C+ ER Sbjct: 360 MCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFT 419 Query: 541 ASELLKNCFLQKDK 582 +LL + F ++++ Sbjct: 420 IQDLLTHAFFREER 433
>WNK4_MOUSE (Q80UE6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 187 bits (475), Expect = 2e-47 Identities = 89/194 (45%), Positives = 130/194 (67%), Gaps = 1/194 (0%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 ++R + + ++TEL TSG+L+ + ++ ++ + ++ W+ QIL GL +LHS+ P I+HRD Sbjct: 240 VLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRD 299 Query: 184 LKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFG 363 LKCDN+FI G G VKIGD GLAT +S+ GT EFMAPE++ Y+E VD+Y+FG Sbjct: 300 LKCDNVFITGPSGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFG 359 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-APVTERLC 540 MCMLEM T EYPYSECQ IY+K++ G KP+ KV+ EV+ IE C+ ER Sbjct: 360 MCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFT 419 Query: 541 ASELLKNCFLQKDK 582 +LL + F ++++ Sbjct: 420 IQDLLAHAFFREER 433
>WNK4_HUMAN (Q96J92) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1243 Score = 186 bits (473), Expect = 4e-47 Identities = 89/194 (45%), Positives = 130/194 (67%), Gaps = 1/194 (0%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 ++R + + ++TEL TSG+L+ + ++ ++ + ++ W+ QIL GL +LHS+ P I+HRD Sbjct: 243 VLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRD 302 Query: 184 LKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFG 363 LKCDN+FI G G VKIGD GLAT +S+ GT EFMAPE++ Y+E VD+Y+FG Sbjct: 303 LKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFG 362 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-APVTERLC 540 MCMLEM T EYPYSECQ IY+K++ G KP+ KV+ EV+ IE C+ ER Sbjct: 363 MCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFT 422 Query: 541 ASELLKNCFLQKDK 582 +LL + F ++++ Sbjct: 423 IQDLLAHAFFREER 436
>WNK2_HUMAN (Q9Y3S1) Serine/threonine-protein kinase WNK2 (EC 2.7.11.1)| (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2) Length = 2297 Score = 186 bits (473), Expect = 4e-47 Identities = 93/184 (50%), Positives = 121/184 (65%), Gaps = 1/184 (0%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++TEL TSG+L+ + K+ + K +R W QIL GL +LH++ P IIHRDLKCDNIFI Sbjct: 273 LVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFIT 332 Query: 211 GHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFGMCMLEMVTC 390 G G VKIGD GLAT +S+ GT EFMAPE++ +Y+E VD+Y+FGMCMLEM T Sbjct: 333 GPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS 392 Query: 391 EYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLCASELLKNCF 567 EYPYSECQ IY+K++ GIKP KV D E++ I C+ ER +LL + F Sbjct: 393 EYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAF 452 Query: 568 LQKD 579 +D Sbjct: 453 FAED 456
>NRBP_MOUSE (Q99J45) Nuclear receptor-binding protein (MLF1 adapter molecule)| (HLS7-interacting protein kinase) Length = 535 Score = 102 bits (255), Expect = 8e-22 Identities = 75/187 (40%), Positives = 95/187 (50%), Gaps = 7/187 (3%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKK----HNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 + V ITE +SGSL+QF KK H + KA + W QIL+ L YLHS +P IIH + Sbjct: 143 KARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGN 202 Query: 184 LKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLEFMAPEL-FTGNYNELVDIYS 357 L CD IFI H+G +KIG T H + R + L F APE N VDIYS Sbjct: 203 LTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYS 261 Query: 358 FGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-APVTER 534 FGMC LEM E + G+ + Q + +ED+ R FI+ CL + R Sbjct: 262 FGMCALEMAVLEI---QGNGES---SYVPQEAISSAIQLLEDSLQREFIQKCLQSEPARR 315 Query: 535 LCASELL 555 A ELL Sbjct: 316 PTARELL 322
>NRBP_PONPY (Q5RBH9) Nuclear receptor-binding protein| Length = 535 Score = 102 bits (254), Expect = 1e-21 Identities = 75/191 (39%), Positives = 95/191 (49%), Gaps = 7/191 (3%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKK----HNKVGMKAMRGWAIQILAGLEYLHSQEPAI 171 + + V ITE +SGSL+QF KK H + KA + W QIL+ L YLHS +P I Sbjct: 139 IKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPI 198 Query: 172 IHRDLKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLEFMAPEL-FTGNYNELV 345 IH +L CD IFI H+G +KIG T H + R + L F APE N V Sbjct: 199 IHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAV 257 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-AP 522 DIYSFGMC LEM E + G+ + Q + +ED R FI+ CL + Sbjct: 258 DIYSFGMCALEMAVLEI---QGNGES---SYVPQEAISSAIQLLEDPLQREFIQKCLQSE 311 Query: 523 VTERLCASELL 555 R A ELL Sbjct: 312 PARRPTARELL 322
>NRBP_MACFA (Q4R8X0) Nuclear receptor-binding protein| Length = 535 Score = 102 bits (254), Expect = 1e-21 Identities = 75/191 (39%), Positives = 95/191 (49%), Gaps = 7/191 (3%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKK----HNKVGMKAMRGWAIQILAGLEYLHSQEPAI 171 + + V ITE +SGSL+QF KK H + KA + W QIL+ L YLHS +P I Sbjct: 139 IKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPI 198 Query: 172 IHRDLKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLEFMAPEL-FTGNYNELV 345 IH +L CD IFI H+G +KIG T H + R + L F APE N V Sbjct: 199 IHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAV 257 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-AP 522 DIYSFGMC LEM E + G+ + Q + +ED R FI+ CL + Sbjct: 258 DIYSFGMCALEMAVLEI---QGNGES---SYVPQEAISSAIQLLEDPLQREFIQKCLQSE 311 Query: 523 VTERLCASELL 555 R A ELL Sbjct: 312 PARRPTARELL 322
>NRBP_HUMAN (Q9UHY1) Nuclear receptor-binding protein| Length = 535 Score = 102 bits (254), Expect = 1e-21 Identities = 75/191 (39%), Positives = 95/191 (49%), Gaps = 7/191 (3%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKK----HNKVGMKAMRGWAIQILAGLEYLHSQEPAI 171 + + V ITE +SGSL+QF KK H + KA + W QIL+ L YLHS +P I Sbjct: 139 IKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPI 198 Query: 172 IHRDLKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLEFMAPEL-FTGNYNELV 345 IH +L CD IFI H+G +KIG T H + R + L F APE N V Sbjct: 199 IHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAV 257 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-AP 522 DIYSFGMC LEM E + G+ + Q + +ED R FI+ CL + Sbjct: 258 DIYSFGMCALEMAVLEI---QGNGES---SYVPQEAISSAIQLLEDPLQREFIQKCLQSE 311 Query: 523 VTERLCASELL 555 R A ELL Sbjct: 312 PARRPTARELL 322
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 91.3 bits (225), Expect = 2e-18 Identities = 63/194 (32%), Positives = 97/194 (50%), Gaps = 6/194 (3%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 R T+ I E GS++ K + + R + QIL G+ YLHS I+HRD+K Sbjct: 434 RAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSN--MIVHRDIK 491 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ-----RKMRSIKGTLEFMAPELFTG-NYNELVDI 351 NI + G VK+GDFG + L MRS+ GT +M+PE+ +G Y D+ Sbjct: 492 GANI-LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADV 550 Query: 352 YSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTE 531 +S G ++EM+T + P++E + I+K +Q P + S + + R F+ + Sbjct: 551 WSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISE-HGRDFLRRIFVEARQ 609 Query: 532 RLCASELLKNCFLQ 573 R A ELL + F Q Sbjct: 610 RPSAEELLTHHFAQ 623
>M3K2_MOUSE (Q61083) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 87.8 bits (216), Expect = 3e-17 Identities = 61/189 (32%), Positives = 97/189 (51%), Gaps = 6/189 (3%) Frame = +1 Query: 22 TVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNI 201 T++I EL GS++ K + + R + QIL G+ YLHS I+HRD+K NI Sbjct: 432 TLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSN--MIVHRDIKGANI 489 Query: 202 FINGHDGQVKIGDFGLATFLHQ-----RKMRSIKGTLEFMAPELFTG-NYNELVDIYSFG 363 + G +K+GDFG + L M+S+ GT +M+PE+ +G Y DI+S Sbjct: 490 -LRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVA 548 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLCA 543 ++EM+T + P++E + I+K +Q P + V D R F++ R A Sbjct: 549 CTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSD-YTRDFLKRIFVEAKLRPSA 607 Query: 544 SELLKNCFL 570 ELL++ F+ Sbjct: 608 EELLRHMFV 616
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 87.8 bits (216), Expect = 3e-17 Identities = 62/194 (31%), Positives = 96/194 (49%), Gaps = 6/194 (3%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 R + I E GS++ K + + R + QIL G+ YLHS I+HRD+K Sbjct: 434 RAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSN--MIVHRDIK 491 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQRKM-----RSIKGTLEFMAPELFTG-NYNELVDI 351 NI + G VK+GDFG + L M RS+ GT +M+PE+ +G Y D+ Sbjct: 492 GANI-LRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADV 550 Query: 352 YSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTE 531 +S G ++EM+T + P++E + I+K +Q P + S + + R F+ + Sbjct: 551 WSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISE-HGRDFLRRIFVEARQ 609 Query: 532 RLCASELLKNCFLQ 573 R A ELL + F Q Sbjct: 610 RPSAEELLTHHFAQ 623
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 86.3 bits (212), Expect = 8e-17 Identities = 61/189 (32%), Positives = 96/189 (50%), Gaps = 6/189 (3%) Frame = +1 Query: 22 TVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNI 201 T++I E GS++ K + + R + QIL G+ YLHS I+HRD+K NI Sbjct: 432 TLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSN--MIVHRDIKGANI 489 Query: 202 FINGHDGQVKIGDFGLATFLHQ-----RKMRSIKGTLEFMAPELFTG-NYNELVDIYSFG 363 + G VK+GDFG + L M+S+ GT +M+PE+ +G Y DI+S Sbjct: 490 -LRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVA 548 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLCA 543 ++EM+T + P++E + I+K +Q P + V D R F++ R A Sbjct: 549 CTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSD-YTRDFLKRIFVEAKLRPSA 607 Query: 544 SELLKNCFL 570 ELL++ F+ Sbjct: 608 DELLRHMFV 616
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 85.9 bits (211), Expect = 1e-16 Identities = 63/190 (33%), Positives = 101/190 (53%), Gaps = 9/190 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHN-KVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFI 207 +I E GSL + + ++ K+ K + + L GL++LH + IIHRD+K DN+ + Sbjct: 754 VIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKH--IIHRDIKSDNVLL 811 Query: 208 NGHDGQVKIGDFGLATFL--HQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLE 378 + + G VKI DFG L + K ++ GT +MAPE+ Y+E VD++S G+ +E Sbjct: 812 DAY-GNVKITDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIE 870 Query: 379 MVTCEYPYSECQGKPWIYKKISQGI----KPDVLSKVEDAEVRGFIEICL-APVTERLCA 543 M+ E PY + +Y + G KP++LS ++ F+ ICL V R Sbjct: 871 MIEGEPPYLNEEPLKALYLIATNGTPKLKKPELLSN----SIKKFLSICLCVDVRYRAST 926 Query: 544 SELLKNCFLQ 573 ELL++ F+Q Sbjct: 927 DELLEHSFIQ 936
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 85.9 bits (211), Expect = 1e-16 Identities = 69/200 (34%), Positives = 103/200 (51%), Gaps = 10/200 (5%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G +R T+NI+ E GS+ +K +R + Q+L GLEYLH+ AI+HR Sbjct: 139 GTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNH--AIMHR 196 Query: 181 DLKCDNIFINGHDGQVKIGDFG----LATFLHQRKMRSIKGTLEFMAPE-LFTGNYNELV 345 D+K NI ++ + G +K+ DFG +A +S+KGT +MAPE + ++ Sbjct: 197 DIKGANILVD-NKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSA 255 Query: 346 DIYSFGMCMLEMVTCEYP----YSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEIC 513 DI+S G ++EMVT + P Y E +I S PD LS ++ + F+ C Sbjct: 256 DIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLS----SDAKDFLLKC 311 Query: 514 LAPVTE-RLCASELLKNCFL 570 L V R ASELLK+ F+ Sbjct: 312 LQEVPNLRPTASELLKHPFV 331
>WRK19_ARATH (Q9SZ67) Probable WRKY transcription factor 19 (WRKY DNA-binding| protein 19) Length = 1895 Score = 85.5 bits (210), Expect = 1e-16 Identities = 68/198 (34%), Positives = 103/198 (52%), Gaps = 8/198 (4%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G + + I EL T GSLR+ ++ N++G + + QIL GL+YLH + IHR Sbjct: 1692 GTTKDESNLYIFLELVTQGSLRKLYQR-NQLGDSVVSLYTRQILDGLKYLHDK--GFIHR 1748 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGT--LEFMAPELFTG-----NYNE 339 ++KC N+ ++ + G VK+ DFGLA K+ S+ T +MAPE+ Y Sbjct: 1749 NIKCANVLVDAN-GTVKLADFGLA------KVMSLWRTPYWNWMAPEVILNPKDYDGYGT 1801 Query: 340 LVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL- 516 DI+S G +LEM+T + PYS+ + +Y I G P + + + R FI CL Sbjct: 1802 PADIWSLGCTVLEMLTGQIPYSDLEIGTALY-NIGTGKLPKI-PDILSLDARDFILTCLK 1859 Query: 517 APVTERLCASELLKNCFL 570 ER A+ELL + F+ Sbjct: 1860 VNPEERPTAAELLNHPFV 1877
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 85.1 bits (209), Expect = 2e-16 Identities = 58/158 (36%), Positives = 89/158 (56%), Gaps = 8/158 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTL 297 QIL GL+YLH + I+HRD+K DN+ IN + G +KI DFG + L + GTL Sbjct: 786 QILEGLKYLHDNQ--IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTL 843 Query: 298 EFMAPELF---TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPW--IYKKISQGIKPD 462 ++MAPE+ Y + DI+S G ++EM T + P+ E G+P ++K + P+ Sbjct: 844 QYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL-GEPQAAMFKVGMFKVHPE 902 Query: 463 VLSKVEDAEVRGFIEICLAP-VTERLCASELLKNCFLQ 573 + + AE + FI C P +R CA++LL + FL+ Sbjct: 903 IPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLK 939
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 84.7 bits (208), Expect = 2e-16 Identities = 58/158 (36%), Positives = 89/158 (56%), Gaps = 8/158 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTL 297 QIL GL+YLH + I+HRD+K DN+ IN + G +KI DFG + L + GTL Sbjct: 793 QILEGLKYLHDNQ--IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTL 850 Query: 298 EFMAPELF---TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPW--IYKKISQGIKPD 462 ++MAPE+ Y + DI+S G ++EM T + P+ E G+P ++K + P+ Sbjct: 851 QYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL-GEPQAAMFKVGMFKVHPE 909 Query: 463 VLSKVEDAEVRGFIEICLAP-VTERLCASELLKNCFLQ 573 + + AE + FI C P +R CA++LL + FL+ Sbjct: 910 IPESM-SAEAKAFILKCFEPDPDKRACANDLLIDEFLK 946
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 83.6 bits (205), Expect = 5e-16 Identities = 53/153 (34%), Positives = 79/153 (51%), Gaps = 2/153 (1%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 II E C G L + + K+ + + W+ I +G+ YLH + IIHRDLK N+ + Sbjct: 231 IIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVT 288 Query: 211 GHDGQVKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMV 384 H VKI DFG + L + + S GT+ +MAPE+ +E VDI+SFG+ + E++ Sbjct: 289 -HTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 347 Query: 385 TCEYPYSECQGKPWIYKKISQGIKPDVLSKVED 483 T E PY + I+ S + V S D Sbjct: 348 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPD 380
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 82.4 bits (202), Expect = 1e-15 Identities = 48/133 (36%), Positives = 74/133 (55%), Gaps = 4/133 (3%) Frame = +1 Query: 31 IITELCTSGSLRQF--RKKHNKVGMKAMRGWAIQILAGLEYLHSQEPA-IIHRDLKCDNI 201 I+TE + GSL + + ++ M+ + WA + G+ YLH + P +IHRDLK N+ Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 139 Query: 202 FINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLE 378 I DG +KI DFG + F + S+ GT +MAPE+ +E D YS+G+ + E Sbjct: 140 VIAA-DGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWE 198 Query: 379 MVTCEYPYSECQG 417 M+T E P+ +G Sbjct: 199 MLTREVPFKGLEG 211
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 82.4 bits (202), Expect = 1e-15 Identities = 62/206 (30%), Positives = 108/206 (52%), Gaps = 12/206 (5%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G +T ++I E + GS+ + + + + +R + Q+L GL YLHS+ IIHR Sbjct: 897 GFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYLHSK--GIIHR 954 Query: 181 DLKCDNIFINGHDGQVKIGDFGLA----TFLHQRKMRSIKGTLEFMAPELFTGN---YNE 339 DLK DN+ I+ DG KI DFG++ S++G++ +MAPE+ + Y+ Sbjct: 955 DLKADNLLID-FDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSA 1013 Query: 340 LVDIYSFGMCMLEMVTCEYPYSECQGKPWIYK----KISQGIKPDVLSKVEDAEVRGFIE 507 VD++S G +LEM+ P+S + ++K K + I +++S+V ++ F+ Sbjct: 1014 KVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQ-FLN 1072 Query: 508 ICLAPVTE-RLCASELLKNCFLQKDK 582 C + R A ELL + F++ D+ Sbjct: 1073 ACFTVNADVRPTAEELLNHPFMKCDE 1098
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/153 (33%), Positives = 79/153 (51%), Gaps = 2/153 (1%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 II E C G L + + K+ + + W+ I +G+ YLH + IIHRDLK N+ + Sbjct: 231 IIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVT 288 Query: 211 GHDGQVKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMV 384 H VKI DFG + L + + S GT+ ++APE+ +E VDI+SFG+ + E++ Sbjct: 289 -HTDAVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELL 347 Query: 385 TCEYPYSECQGKPWIYKKISQGIKPDVLSKVED 483 T E PY + I+ S + V S D Sbjct: 348 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPD 380
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 82.0 bits (201), Expect = 1e-15 Identities = 57/160 (35%), Positives = 85/160 (53%), Gaps = 14/160 (8%) Frame = +1 Query: 25 VNIITELCTSGSL-RQFRKKHNKVG--MKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + IIT+ C SL R + +V M A+ Q+ G+ YLHS+ IIHRDLK + Sbjct: 549 IAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHSKN--IIHRDLKTN 606 Query: 196 NIFINGHDGQVKIGDFGLATFLHQ------RKMRSIKGTLEFMAPELF----TGNYNELV 345 NIF+ VKIGDFGLAT + ++ + G++ +MAPE+ Y Sbjct: 607 NIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQS 666 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG-IKPD 462 D+YSFG+CM E+++ PYS + I + +G ++PD Sbjct: 667 DVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPD 706
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 82.0 bits (201), Expect = 1e-15 Identities = 55/178 (30%), Positives = 92/178 (51%), Gaps = 8/178 (4%) Frame = +1 Query: 25 VNIITELCTSGSL----RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 +NI+ EL +G L + F+K+ + + + + +Q+ + L+++HS+ ++HRD+K Sbjct: 107 LNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRR--VMHRDIKP 164 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPE-LFTGNYNELVDIYSFG 363 N+FI G VK+GD GL F + S+ GT +M+PE + YN DI+S G Sbjct: 165 ANVFITA-TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLG 223 Query: 364 MCMLEMVTCEYP-YSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTER 534 + EM + P Y + + KKI Q P + S E+R + IC+ P E+ Sbjct: 224 CLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEK 281
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 82.0 bits (201), Expect = 1e-15 Identities = 55/178 (30%), Positives = 92/178 (51%), Gaps = 8/178 (4%) Frame = +1 Query: 25 VNIITELCTSGSL----RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 +NI+ EL +G L + F+K+ + + + + +Q+ + LE++HS+ ++HRD+K Sbjct: 107 LNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR--VMHRDIKP 164 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPE-LFTGNYNELVDIYSFG 363 N+FI G VK+GD GL F + S+ GT +M+PE + YN DI+S G Sbjct: 165 ANVFITA-TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLG 223 Query: 364 MCMLEMVTCEYP-YSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTER 534 + EM + P Y + + KKI Q P + S E+R + +C+ P E+ Sbjct: 224 CLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEK 281
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 81.6 bits (200), Expect = 2e-15 Identities = 48/133 (36%), Positives = 73/133 (54%), Gaps = 4/133 (3%) Frame = +1 Query: 31 IITELCTSGSLRQF--RKKHNKVGMKAMRGWAIQILAGLEYLHSQEPA-IIHRDLKCDNI 201 I+TE + GSL + + ++ M + WA + G+ YLH + P +IHRDLK N+ Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 139 Query: 202 FINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLE 378 I DG +KI DFG + F + S+ GT +MAPE+ +E D YS+G+ + E Sbjct: 140 VIAA-DGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWE 198 Query: 379 MVTCEYPYSECQG 417 M+T E P+ +G Sbjct: 199 MLTREVPFKGLEG 211
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 81.6 bits (200), Expect = 2e-15 Identities = 55/165 (33%), Positives = 91/165 (55%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL + + K M + A Q G++YLH++ IIHRD+K Sbjct: 413 TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 470 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELF----TGNYNEL 342 +NIF+ H+G VKIGDFGLAT + +++ G++ +MAPE+ + ++ Sbjct: 471 SNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQ 528 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+YS+G+ + E++T E PYS + I + +G LSK+ Sbjct: 529 SDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKL 573
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 81.6 bits (200), Expect = 2e-15 Identities = 57/171 (33%), Positives = 88/171 (51%), Gaps = 9/171 (5%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNK---VGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNI 201 ++ E GSL + +K +A+R WA+Q L YLHS + I+HRD+K N+ Sbjct: 81 LLMEYLEEGSLHNYLYGDDKWEYTVEQAVR-WALQCAKALAYLHSLDRPIVHRDIKPQNM 139 Query: 202 FINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLE 378 + +KI DFGLAT + K ++GTL +MAPE Y D+YSFG+ + E Sbjct: 140 LLYNQHEDLKICDFGLATDMSNNK-TDMQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWE 198 Query: 379 MVTCEYPYSECQ---GKPWIYKKISQGIKPDVLSKVEDAE--VRGFIEICL 516 ++T + PYS + + I K IS G K + + D ++ +E C+ Sbjct: 199 LMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCM 249
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ +IIHRDLK Sbjct: 561 TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLK 618 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + + + G++ +MAPE+ Y+ Sbjct: 619 SNNIFLH-EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS 677 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y+FG+ + E++T + PYS + I + +G LSKV Sbjct: 678 DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 721
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ +IIHRDLK Sbjct: 147 TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLK 204 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + + + G++ +MAPE+ Y+ Sbjct: 205 SNNIFLH-EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS 263 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y+FG+ + E++T + PYS + I + +G LSKV Sbjct: 264 DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 307
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 81.3 bits (199), Expect = 2e-15 Identities = 53/153 (34%), Positives = 78/153 (50%), Gaps = 2/153 (1%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I+ E C G L + + V + W++ I G+ YLH + IIHRDLK N+ I Sbjct: 188 ILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK--IIHRDLKSPNMLIT 245 Query: 211 GHDGQVKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMV 384 +D VKI DFG + L + + S GT+ +MAPE+ +E VDI+SFG+ + E++ Sbjct: 246 -YDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 304 Query: 385 TCEYPYSECQGKPWIYKKISQGIKPDVLSKVED 483 T E PY + I+ S + V S D Sbjct: 305 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPD 337
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ +IIHRDLK Sbjct: 521 TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLK 578 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + + + G++ +MAPE+ Y+ Sbjct: 579 SNNIFLH-EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS 637 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y+FG+ + E++T + PYS + I + +G LSKV Sbjct: 638 DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 681
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ +IIHRDLK Sbjct: 83 TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLK 140 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + + + G++ +MAPE+ Y+ Sbjct: 141 SNNIFLH-EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS 199 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y+FG+ + E++T + PYS + I + +G LSKV Sbjct: 200 DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 243
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ +IIHRDLK Sbjct: 561 TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLK 618 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + + + G++ +MAPE+ Y+ Sbjct: 619 SNNIFLH-EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS 677 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y+FG+ + E++T + PYS + I + +G LSKV Sbjct: 678 DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 721
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 81.3 bits (199), Expect = 2e-15 Identities = 54/164 (32%), Positives = 90/164 (54%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL + + K M + A Q G++YLH++ IIHRD+K Sbjct: 146 TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 203 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELF----TGNYNELV 345 +NIF++G VKIGDFGLAT + +++ G++ +MAPE+ + ++ Sbjct: 204 SNNIFLHG-GLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQS 262 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+YS+G+ + E++T E PYS + I + +G LSK+ Sbjct: 263 DVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKL 306
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 9/164 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ +IIHRDLK Sbjct: 131 TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLK 188 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + + + G++ +MAPE+ Y+ Sbjct: 189 SNNIFLH-EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS 247 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y+FG+ + E++T + PYS + I + +G LSKV Sbjct: 248 DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 291
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 81.3 bits (199), Expect = 2e-15 Identities = 53/153 (34%), Positives = 78/153 (50%), Gaps = 2/153 (1%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I+ E C G L + + V + W++ I G+ YLH + IIHRDLK N+ I Sbjct: 221 ILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK--IIHRDLKSPNMLIT 278 Query: 211 GHDGQVKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMV 384 +D VKI DFG + L + + S GT+ +MAPE+ +E VDI+SFG+ + E++ Sbjct: 279 -YDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 337 Query: 385 TCEYPYSECQGKPWIYKKISQGIKPDVLSKVED 483 T E PY + I+ S + V S D Sbjct: 338 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPD 370
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 81.3 bits (199), Expect = 2e-15 Identities = 53/153 (34%), Positives = 78/153 (50%), Gaps = 2/153 (1%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I+ E C G L + + V + W++ I G+ YLH + IIHRDLK N+ I Sbjct: 221 ILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK--IIHRDLKSPNMLIT 278 Query: 211 GHDGQVKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMV 384 +D VKI DFG + L + + S GT+ +MAPE+ +E VDI+SFG+ + E++ Sbjct: 279 -YDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 337 Query: 385 TCEYPYSECQGKPWIYKKISQGIKPDVLSKVED 483 T E PY + I+ S + V S D Sbjct: 338 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPD 370
>PLK3_CAEEL (Q20845) Serine/threonine-protein kinase plk-3 (EC 2.7.11.21)| (Polo-like kinase 3) Length = 615 Score = 80.9 bits (198), Expect = 3e-15 Identities = 60/175 (34%), Positives = 96/175 (54%), Gaps = 5/175 (2%) Frame = +1 Query: 40 ELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHD 219 ELC+ SL + K+ + R + IQ+ G+++LH+ + IIHRDLK N+F+N H Sbjct: 113 ELCSKNSLMELNKQRGPLTEHEARFYTIQVAEGVKHLHNLQ--IIHRDLKLGNLFLNEHL 170 Query: 220 GQVKIGDFGLATFLHQRKMRSIK-GTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTC 390 QVKIGDFGLATF + + + + GT ++APE+ TG+ E VDI++ G C+L ++ Sbjct: 171 -QVKIGDFGLATFCEKNEKKMTRGGTPNYIAPEVLNETGHAFE-VDIWAIG-CILYVLLF 227 Query: 391 EYPYSECQGKPWIYKKISQG--IKPDVLSKVEDAEVRGFIEICLAPVTERLCASE 549 P E + Y +I + P+ S + +R ++ PV +R +E Sbjct: 228 GSPPFESRRVQETYVRIKNNDYVVPENASPTANRLIRSLLD----PVPDRRPTAE 278
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 80.9 bits (198), Expect = 3e-15 Identities = 56/165 (33%), Positives = 89/165 (53%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL + + K M + A Q G++YLH++ IIHRD+K Sbjct: 413 TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 470 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFTGNYNELV--- 345 +NIF+ H+G VKIGDFGLAT + +++ G++ +MAPE+ N Sbjct: 471 SNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 528 Query: 346 -DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+YS+G+ + E++T E PYS + I + +G LSK+ Sbjct: 529 SDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKL 573
>PAK4_HUMAN (O96013) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 591 Score = 80.5 bits (197), Expect = 4e-15 Identities = 61/188 (32%), Positives = 101/188 (53%), Gaps = 6/188 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E G+L H ++ + + + +L L LH+Q +IHRD+K D+I + Sbjct: 393 VVMEFLEGGALTDI-VTHTRMNEEQIAAVCLAVLQALSVLHAQ--GVIHRDIKSDSILLT 449 Query: 211 GHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 HDG+VK+ DFG + + + +S+ GT +MAPEL + Y VDI+S G+ ++EM Sbjct: 450 -HDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEM 508 Query: 382 VTCEYPYSECQGKPWIYKKISQGIKPDV--LSKVEDAEVRGFIE-ICLAPVTERLCASEL 552 V E PY + K I + P + L KV + ++GF++ + + +R A+EL Sbjct: 509 VDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPS-LKGFLDRLLVRDPAQRATAAEL 566 Query: 553 LKNCFLQK 576 LK+ FL K Sbjct: 567 LKHPFLAK 574
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 80.5 bits (197), Expect = 4e-15 Identities = 56/177 (31%), Positives = 92/177 (51%), Gaps = 6/177 (3%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G +T ++ II E C +GSLR K K+ + + Q+L GL YLH+Q +IHR Sbjct: 73 GSYQTNDSLCIILEYCENGSLRSICKNFGKIPENLVALYTFQVLQGLLYLHNQ--GVIHR 130 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNYNELV----- 345 D+K NI + DG +K+ DFG+AT ++ + S+ G+ +MAPE+ ELV Sbjct: 131 DIKGANI-LTTKDGTIKLADFGVATKINALEDHSVVGSPYWMAPEVI-----ELVGATTA 184 Query: 346 -DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEIC 513 DI+S G ++E++ PY + +++ + P + S + A + F+ C Sbjct: 185 SDIWSVGCTVIELLDGNPPYYDLDPTSALFRMVKDE-HPPLPSNISSA-AKSFLMQC 239
>M3K4_MOUSE (O08648) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 80.5 bits (197), Expect = 4e-15 Identities = 62/204 (30%), Positives = 102/204 (50%), Gaps = 13/204 (6%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMK--AMRGWAIQILAGLEYLHSQEPAII 174 G+ R + I E C G+L + +++G++ +R + QI + LH E I+ Sbjct: 1396 GVELHREEMYIFMEYCDEGTLEEV----SRLGLQEHVIRLYTKQITVAINVLH--EHGIV 1449 Query: 175 HRDLKCDNIFINGHDGQVKIGDFGLATFLHQR------KMRSIKGTLEFMAPELFTG--- 327 HRD+K NIF+ G +K+GDFG + L ++ S GT +MAPE+ T Sbjct: 1450 HRDIKGANIFLTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKG 1508 Query: 328 -NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFI 504 + DI+S G ++EMVT + P+ E + I K+ G KP + ++ E + F+ Sbjct: 1509 EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERL-SPEGKAFL 1567 Query: 505 EICLAPVTE-RLCASELLKNCFLQ 573 CL + R AS+LL + F++ Sbjct: 1568 SHCLESDPKIRWTASQLLDHAFVK 1591
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 80.1 bits (196), Expect = 5e-15 Identities = 48/128 (37%), Positives = 76/128 (59%), Gaps = 4/128 (3%) Frame = +1 Query: 31 IITELCTSGSLRQF--RKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 IITE + G+LR + +K+ + ++ + A+ I G+EYLHSQ +IHRDLK +N+ Sbjct: 162 IITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQ--GVIHRDLKSNNLL 219 Query: 205 INGHDGQVKIGDFGLATFLHQ-RKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLE 378 +N + +VK+ DFG + Q R+ + GT +MAPE+ Y VD+YSFG+ + E Sbjct: 220 LND-EMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWE 278 Query: 379 MVTCEYPY 402 + T P+ Sbjct: 279 LTTALLPF 286
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 80.1 bits (196), Expect = 5e-15 Identities = 46/124 (37%), Positives = 73/124 (58%), Gaps = 3/124 (2%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEP-AIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKG 291 W +Q G+ YLHS +P A+IHRDLK N+ + +KI DFG A + Q M + KG Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-QTHMTNNKG 191 Query: 292 TLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPW-IYKKISQGIKPDV 465 + +MAPE+F G NY+E D++S+G+ + E++T P+ E G + I + G +P + Sbjct: 192 SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPL 251 Query: 466 LSKV 477 + + Sbjct: 252 IKNL 255
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 80.1 bits (196), Expect = 5e-15 Identities = 46/124 (37%), Positives = 73/124 (58%), Gaps = 3/124 (2%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEP-AIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKG 291 W +Q G+ YLHS +P A+IHRDLK N+ + +KI DFG A + Q M + KG Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-QTHMTNNKG 191 Query: 292 TLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPW-IYKKISQGIKPDV 465 + +MAPE+F G NY+E D++S+G+ + E++T P+ E G + I + G +P + Sbjct: 192 SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPL 251 Query: 466 LSKV 477 + + Sbjct: 252 IKNL 255
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 80.1 bits (196), Expect = 5e-15 Identities = 57/191 (29%), Positives = 94/191 (49%), Gaps = 9/191 (4%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 +NI E GS+ + ++ + Q L GLEYLHS+ I+HRD+K NI Sbjct: 472 LNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSR--GIVHRDIKGANIL 529 Query: 205 INGHDGQVKIGDFGLATFLHQRKMR--------SIKGTLEFMAPELFTGN-YNELVDIYS 357 ++ + G++KI DFG++ L S +G+ +MAPE+ + E DI+S Sbjct: 530 VD-NKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWS 588 Query: 358 FGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERL 537 G ++EM+T ++PY C I+ +I + I P+ S + + + + R Sbjct: 589 LGCLVIEMLTSKHPYPNCDQMQAIF-RIGENILPEFPSNISSSAIDFLEKTFAIDCNLRP 647 Query: 538 CASELLKNCFL 570 ASELL + F+ Sbjct: 648 TASELLSHPFV 658
>PAK4_MOUSE (Q8BTW9) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 593 Score = 80.1 bits (196), Expect = 5e-15 Identities = 60/188 (31%), Positives = 99/188 (52%), Gaps = 6/188 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E G+L H ++ + + + +L L LH+Q +IHRD+K D+I + Sbjct: 395 VVMEFLEGGALTDI-VTHTRMNEEQIAAVCLAVLQALAVLHAQ--GVIHRDIKSDSILLT 451 Query: 211 GHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 HDG+VK+ DFG + + + +S+ GT +MAPEL + Y VDI+S G+ ++EM Sbjct: 452 -HDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEM 510 Query: 382 VTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDA--EVRGFIE-ICLAPVTERLCASEL 552 V E PY P K+ + P L + A ++GF++ + + +R A+EL Sbjct: 511 VDGEPPY--FNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAEL 568 Query: 553 LKNCFLQK 576 LK+ FL K Sbjct: 569 LKHPFLTK 576
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 79.7 bits (195), Expect = 7e-15 Identities = 68/206 (33%), Positives = 104/206 (50%), Gaps = 16/206 (7%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G +R T+NI+ E GS+ +K +R + Q+L GLEYLH+ AI+HR Sbjct: 138 GTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHNH--AIMHR 195 Query: 181 DLKCDNIFINGHDGQVKIGDFG----LATFLHQRKMRSIKGTLEFMAPE-LFTGNYNELV 345 D+K NI ++ + G +K+ DFG +A +S+KGT +MAPE + ++ Sbjct: 196 DIKGANILVD-NQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHSFSA 254 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKI----------SQGIKPDVLSKVEDAEVR 495 DI+S G ++EMVT + P+S+ YK+I S PD +S ++ Sbjct: 255 DIWSVGCTVIEMVTGKAPWSQ------QYKEIAAIFHIGTTKSHPPIPDNIS----SDAN 304 Query: 496 GFIEICLAPVTE-RLCASELLKNCFL 570 F+ CL R ASELLK+ F+ Sbjct: 305 DFLLKCLQQEPNLRPTASELLKHPFV 330
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 79.7 bits (195), Expect = 7e-15 Identities = 48/133 (36%), Positives = 75/133 (56%), Gaps = 9/133 (6%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEP-AIIHRDLKCDNIF- 204 ++ E GSL + K+ + WAIQI G+ YLH++ P +IIHRDLK N+ Sbjct: 215 LVMEYARGGSLNRILA--GKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLI 272 Query: 205 ---INGHDGQ---VKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT-GNYNELVDIYSFG 363 I G+ Q +KI DFGLA ++ + S GT +M PE+ + Y++ D++S+G Sbjct: 273 YEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYG 332 Query: 364 MCMLEMVTCEYPY 402 + + E++T E PY Sbjct: 333 VLLWELITGETPY 345
>M3K4_HUMAN (Q9Y6R4) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 79.7 bits (195), Expect = 7e-15 Identities = 62/204 (30%), Positives = 103/204 (50%), Gaps = 13/204 (6%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMK--AMRGWAIQILAGLEYLHSQEPAII 174 G+ R + I E C G+L + +++G++ +R ++ QI + LH E I+ Sbjct: 1406 GVELHREEMYIFMEYCDEGTLEEV----SRLGLQEHVIRLYSKQITIAINVLH--EHGIV 1459 Query: 175 HRDLKCDNIFINGHDGQVKIGDFGLATFLHQR------KMRSIKGTLEFMAPELFTG--- 327 HRD+K NIF+ G +K+GDFG + L ++ S GT +MAPE+ T Sbjct: 1460 HRDIKGANIFLTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKG 1518 Query: 328 -NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFI 504 + DI+S G ++EMVT + P+ E + I K+ G KP + ++ E + F+ Sbjct: 1519 EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERL-SPEGKDFL 1577 Query: 505 EICL-APVTERLCASELLKNCFLQ 573 CL + R AS+LL + F++ Sbjct: 1578 SHCLESDPKMRWTASQLLDHSFVK 1601
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.7 bits (195), Expect = 7e-15 Identities = 55/165 (33%), Positives = 89/165 (53%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL + + K M + A Q G++YLH++ IIHRD+K Sbjct: 413 TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 470 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFTGNYNELV--- 345 +NIF+ H+G VKIGDFGLAT + +++ G++ +MAPE+ N Sbjct: 471 SNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 528 Query: 346 -DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+YS+G+ + E++T E PYS + I + +G LS++ Sbjct: 529 SDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRL 573
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 79.7 bits (195), Expect = 7e-15 Identities = 59/187 (31%), Positives = 100/187 (53%), Gaps = 6/187 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E G+L H ++ + + + +L L YLH+Q +IHRD+K D+I + Sbjct: 521 VVMEFLEGGALTDI-VTHTRMNEEQIATVCLSVLRALSYLHNQ--GVIHRDIKSDSILLT 577 Query: 211 GHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 DG++K+ DFG + + K +S+ GT +MAPE+ + Y VDI+S G+ ++EM Sbjct: 578 S-DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEM 636 Query: 382 VTCEYPYSECQGKPWIYKKISQGIKPDV--LSKVEDAEVRGFIEICLA-PVTERLCASEL 552 + E PY + ++I + P V L KV +RGF+++ L ++R A EL Sbjct: 637 IDGEPPYFN-EPPLQAMRRIRDSLPPRVKDLHKVSSV-LRGFLDLMLVREPSQRATAQEL 694 Query: 553 LKNCFLQ 573 L + FL+ Sbjct: 695 LGHPFLK 701
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 79.3 bits (194), Expect = 9e-15 Identities = 59/187 (31%), Positives = 101/187 (54%), Gaps = 6/187 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E G+L H ++ + + + +L L YLH+Q +IHRD+K D+I + Sbjct: 521 VVMEFLEGGALTDI-VTHTRMNEEQIATVCLSVLKALSYLHNQ--GVIHRDIKSDSILLT 577 Query: 211 GHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 DG++K+ DFG + + K +S+ GT +MAPE+ + Y VDI+S G+ ++EM Sbjct: 578 S-DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEM 636 Query: 382 VTCEYPYSECQGKPWIYKKISQGIKPDV--LSKVEDAEVRGFIEICLA-PVTERLCASEL 552 + E PY + ++I + P V L KV + +RGF+++ L ++R A EL Sbjct: 637 IDGEPPYFN-EPPLQAMRRIRDSLPPRVKDLHKV-SSMLRGFLDLMLVREPSQRATAQEL 694 Query: 553 LKNCFLQ 573 L + FL+ Sbjct: 695 LGHPFLK 701
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 79.3 bits (194), Expect = 9e-15 Identities = 60/155 (38%), Positives = 85/155 (54%), Gaps = 5/155 (3%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 ++L LE+LHS+ +IHRD+K DNI + G DG VK+ DFG L QRK ++ GT Sbjct: 397 EVLQALEFLHSRH--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQLSPEQRKRTTMVGTP 453 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSK 474 +MAPE+ T Y VD++S G+ +EMV E PY IY + G KPD + Sbjct: 454 YWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNG-KPDFPGR 512 Query: 475 VEDAEV-RGFIEICL-APVTERLCASELLKNCFLQ 573 + + F++ L V R AS+LL + FL+ Sbjct: 513 DSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLR 547
>TAOK3_CHICK (Q9I9E0) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Kinase from chicken) Length = 898 Score = 79.3 bits (194), Expect = 9e-15 Identities = 62/195 (31%), Positives = 98/195 (50%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS IHRD+K Sbjct: 96 TAWLVMEYCLGSASDMLEVHKKPLQEVEIAAITHGALQ---GLAYLHSH--CKIHRDIKA 150 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ + S GT +MAPE+ G Y+ VD++S Sbjct: 151 GNILLT-EPGQVKLADFGSASIVSPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 207 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S RGF++ CL + ER Sbjct: 208 GITCIELAERKPPLFNMNAMSALYH-IAQNDSPTLQSNEWSDSFRGFVDYCLQKIPQERP 266 Query: 538 CASELLKNCFLQKDK 582 +++LL++ F+++D+ Sbjct: 267 SSADLLRHDFVRRDR 281
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 79.0 bits (193), Expect = 1e-14 Identities = 52/123 (42%), Positives = 78/123 (63%), Gaps = 6/123 (4%) Frame = +1 Query: 40 ELCTSGSLRQFRKKHN--KVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFING 213 E C G+L Q+ + N KV + QI+ G+EY+HS+ +IHRDLK NIF+ Sbjct: 329 EFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSK--GLIHRDLKPGNIFLVD 386 Query: 214 HDGQVKIGDFGLATFL-HQRKMRSIK-GTLEFMAPE-LFTGNYNELVDIYSFGMCMLEMV 384 + +KIGDFGLAT L + K R+ + GTL++M+PE LF +Y + VDI++ G+ + E++ Sbjct: 387 -ERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGKEVDIFALGLILAELL 445 Query: 385 -TC 390 TC Sbjct: 446 HTC 448
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 79.0 bits (193), Expect = 1e-14 Identities = 49/137 (35%), Positives = 80/137 (58%), Gaps = 3/137 (2%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNK-VGMKAMRGWAIQILAGLEYLHSQEPAIIH 177 G +R + I+ E C +GSLR+ + + + + + Q L GL+YLH + +IH Sbjct: 87 GFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGE--GVIH 144 Query: 178 RDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGNY--NELVDI 351 RD+K NI ++ D VK+ DFG++T ++ + ++ GTL +MAPE+ GN + L DI Sbjct: 145 RDIKAANILLSA-DNTVKLADFGVSTIVNSSAL-TLAGTLNWMAPEIL-GNRGASTLSDI 201 Query: 352 YSFGMCMLEMVTCEYPY 402 +S G ++EM+T PY Sbjct: 202 WSLGATVVEMLTKNPPY 218
>KIC1_YEAST (P38692) Serine/threonine-protein kinase KIC1 (EC 2.7.11.1) (Kinase| that interacts with CDC31) (N-rich kinase 1) Length = 1080 Score = 79.0 bits (193), Expect = 1e-14 Identities = 60/189 (31%), Positives = 98/189 (51%), Gaps = 5/189 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 II E C GSLR + K+ K + ++L L+ +H +IHRD+K N+ I Sbjct: 97 IIMEHCAGGSLRSLLRP-GKIDEKYIGVIMRELLVALKCIHKDN--VIHRDIKAANVLIT 153 Query: 211 GHDGQVKIGDFGLATFLHQRKMR--SIKGTLEFMAPELFTGN--YNELVDIYSFGMCMLE 378 ++G VK+ DFG+A ++Q +R ++ GT +MAPE+ Y+ VDI+S G+ E Sbjct: 154 -NEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYE 212 Query: 379 MVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-APVTERLCASELL 555 + T PY + + + I + P + + ++ FI +CL ERL A +LL Sbjct: 213 IATGNPPYCDVEALR-AMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLL 271 Query: 556 KNCFLQKDK 582 K+ F++ K Sbjct: 272 KSKFIRAHK 280
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 79.0 bits (193), Expect = 1e-14 Identities = 59/158 (37%), Positives = 85/158 (53%), Gaps = 8/158 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 372 ECLQALEFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 428 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EM+ E PY +Y + G P+ Sbjct: 429 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE 488 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQ 573 LS + R F++ CL V +R A ELL++ FL+ Sbjct: 489 KLSAI----FRDFLQCCLEMDVEKRGSAKELLQHQFLK 522
>KPC1_CANAL (P43057) Protein kinase C-like 1 (EC 2.7.11.13) (PKC 1)| Length = 1097 Score = 78.6 bits (192), Expect = 2e-14 Identities = 46/134 (34%), Positives = 74/134 (55%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T + + E + G L +K N+ K + +A ++L GL+Y H I++RDLK Sbjct: 841 QTENRIYFVMEYISGGDLMWHIQK-NRFTAKRAKFYACEVLLGLKYFHDN--GIVYRDLK 897 Query: 190 CDNIFINGHDGQVKIGDFGLAT--FLHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSF 360 DNI + G +KIGD+GL H+ + GT EFMAPE+ G Y+ VD ++F Sbjct: 898 LDNILLTTK-GHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAF 956 Query: 361 GMCMLEMVTCEYPY 402 G+ + +M+ C+ P+ Sbjct: 957 GVLLFQMLLCQSPF 970
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 78.6 bits (192), Expect = 2e-14 Identities = 58/166 (34%), Positives = 92/166 (55%), Gaps = 11/166 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSLR-QFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL K M + A Q G++YLH++ IIHRD+K Sbjct: 404 TKDNLAIVTQWCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 461 Query: 190 CDNIFINGHDG-QVKIGDFGLAT----FLHQRKMRSIKGTLEFMAPELFTGNYNELV--- 345 +NIF+ H+G VKIGDFGLAT + +++ + G++ +MAPE+ N Sbjct: 462 SNNIFL--HEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQ 519 Query: 346 -DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQ-GIKPDVLSKV 477 D+YS+G+ + E++T E PYS + + I + + G+ PD LSK+ Sbjct: 520 SDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPD-LSKL 564
>PLK2_CAEEL (Q9N2L7) Serine/threonine-protein kinase plk-2 (EC 2.7.11.21)| (Polo-like kinase 2) Length = 632 Score = 78.2 bits (191), Expect = 2e-14 Identities = 60/193 (31%), Positives = 96/193 (49%), Gaps = 8/193 (4%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + V I ELC SL + K+ V R + QI+ G+ YLH+ + I+HRDLK Sbjct: 106 KSNVYITLELCPRRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLK--IVHRDLKLG 163 Query: 196 NIFINGHDGQVKIGDFGLATFL-HQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMC 369 N+F+N + QVKIGDFGLAT + + +++ GT ++APE+ ++ VD+++ G C Sbjct: 164 NLFLN-DELQVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIG-C 221 Query: 370 MLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTER----- 534 +L ++ +P E + Y +I V+ A I + L PV R Sbjct: 222 ILYILLFGHPPFESKSLEETYSRIKN--NNYVIPTSASAAASQLIRVLLDPVPSRRPNAR 279 Query: 535 -LCASELLKNCFL 570 +C K+ F+ Sbjct: 280 AVCRDHFFKSGFM 292
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 78.2 bits (191), Expect = 2e-14 Identities = 56/182 (30%), Positives = 87/182 (47%), Gaps = 16/182 (8%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 R V I E C GSL ++ + +Q+L GL Y+HSQ I+HRD+K Sbjct: 1108 REKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQH--ILHRDIKPA 1165 Query: 196 NIFINGHDGQVKIGDFGLATFLH------------QRKMRSIKGTLEFMAPELFTGNYN- 336 NI ++ H G +K DFG A ++ Q +++ + GT +MAPE+ G Sbjct: 1166 NILLD-HRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKG 1224 Query: 337 --ELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEV-RGFIE 507 +DI+S G +LEM+T P+SE + I ++ P + + + + R FIE Sbjct: 1225 DFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIE 1284 Query: 508 IC 513 C Sbjct: 1285 QC 1286
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 77.8 bits (190), Expect = 3e-14 Identities = 53/168 (31%), Positives = 89/168 (52%), Gaps = 10/168 (5%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 ++ ++ I+T+ C SL + K + + Q+ G++YLH++ IIHRDLK Sbjct: 493 SKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKN--IIHRDLK 550 Query: 190 CDNIFINGHDGQVKIGDFGLAT----FLHQRKMRSIKGTLEFMAPELFT----GNYNELV 345 +NIF++ D VKIGDFGLAT + +++ G++ +MAPE+ Y+ Sbjct: 551 SNNIFLH-EDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQS 609 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG-IKPDVLSKVEDA 486 D+Y+FG+ M E++ PY K I + +G ++PD+ DA Sbjct: 610 DVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDA 657
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 77.8 bits (190), Expect = 3e-14 Identities = 61/190 (32%), Positives = 100/190 (52%), Gaps = 8/190 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E +GSL +K +K+ + ++ G+++LH++ IIHRD+K DN+ ++ Sbjct: 387 VVMEYMNAGSLTDIIEK-SKLTEAQIARICLETCKGIQHLHARN--IIHRDIKSDNVLLD 443 Query: 211 GHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEM 381 + G +KI DFG L R K ++ GT +MAPE+ N Y VDI+S G+ ++EM Sbjct: 444 -NSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEM 502 Query: 382 VTCEYPYSECQGKPWIYKKISQGI----KPDVLSKVEDAEVRGFIEICLAPVT-ERLCAS 546 + E PY +Y G KP+++SK ++ F+ CL T R A+ Sbjct: 503 IENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSK----NLKSFLNSCLTIDTIFRATAA 558 Query: 547 ELLKNCFLQK 576 ELL + FL + Sbjct: 559 ELLTHSFLNQ 568
>KPCT_HUMAN (Q04759) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 706 Score = 77.8 bits (190), Expect = 3e-14 Identities = 45/134 (33%), Positives = 75/134 (55%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T+ + + E G L + +K + +A +I+ GL++LHS+ I++RDLK Sbjct: 449 QTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSK--GIVYRDLK 506 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSF 360 DNI ++ DG +KI DFG+ L K + GT +++APE+ G YN VD +SF Sbjct: 507 LDNILLD-KDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSF 565 Query: 361 GMCMLEMVTCEYPY 402 G+ + EM+ + P+ Sbjct: 566 GVLLYEMLIGQSPF 579
>TAOK3_HUMAN (Q9H2K8) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen H Length = 898 Score = 77.8 bits (190), Expect = 3e-14 Identities = 63/195 (32%), Positives = 97/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+ GL YLHS A+IHRD+K Sbjct: 96 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALH---GLAYLHSH--ALIHRDIKA 150 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELF----TGNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VDI+S Sbjct: 151 GNILLT-EPGQVKLADFGSASM--ASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSL 207 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + ER Sbjct: 208 GITCIELAERKPPLFNMNAMSALY-HIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERP 266 Query: 538 CASELLKNCFLQKDK 582 ++ELL++ F+++D+ Sbjct: 267 TSAELLRHDFVRRDR 281
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 77.8 bits (190), Expect = 3e-14 Identities = 46/127 (36%), Positives = 69/127 (54%), Gaps = 4/127 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ ELC GSL + K+ + Q++A ++Y+H + I+HRDL N+FI Sbjct: 82 LVMELCEGGSLMDYVKQKGPLDDSTAVHILRQLIAAVKYIHDEN--ILHRDLSAGNVFIK 139 Query: 211 GHDGQ---VKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGNYNELVDIYSFGMCMLE 378 VK+GDFGLAT L Q +I GT F+AP++F NY++ D+YS G + Sbjct: 140 DATKSTITVKLGDFGLATNLGQHGTACTIVGTPGFIAPQVFGQNYDQAADVYSLGAVLYT 199 Query: 379 MVTCEYP 399 M+T P Sbjct: 200 MLTKHTP 206
>KPCT_MOUSE (Q02111) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 707 Score = 77.4 bits (189), Expect = 4e-14 Identities = 44/134 (32%), Positives = 75/134 (55%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T+ + + E G L + +K + +A +++ GL++LHS+ I++RDLK Sbjct: 449 QTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSK--GIVYRDLK 506 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSF 360 DNI ++ DG +KI DFG+ L K + GT +++APE+ G YN VD +SF Sbjct: 507 LDNILLD-RDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSF 565 Query: 361 GMCMLEMVTCEYPY 402 G+ + EM+ + P+ Sbjct: 566 GVLVYEMLIGQSPF 579
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 77.4 bits (189), Expect = 4e-14 Identities = 59/158 (37%), Positives = 84/158 (53%), Gaps = 8/158 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 371 ECLQALEFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 427 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EM+ E PY +Y + G P+ Sbjct: 428 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE 487 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQ 573 LS + R F+ CL V +R A ELL++ FL+ Sbjct: 488 KLSAI----FRDFLNRCLEMDVEKRGSAKELLQHQFLK 521
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 77.4 bits (189), Expect = 4e-14 Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 6/133 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHN-KVG----MKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 I+TE G+LR K + K+ +K + G A+ G++YLHS P I+HRD+K Sbjct: 1436 IVTEYMRMGNLRDVLKNPDIKITFANKLKLLYGAAM----GIDYLHSSNPMIVHRDIKPA 1491 Query: 196 NIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCM 372 NI ++ H VKI DFG A + GT + APE+ G Y E D++SFG+ M Sbjct: 1492 NILVDEH-FNVKIADFGFARIKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVM 1550 Query: 373 LEMVTCEYPYSEC 411 E++T + P++EC Sbjct: 1551 WEVLTGKEPFAEC 1563 Score = 62.8 bits (151), Expect = 9e-10 Identities = 43/138 (31%), Positives = 70/138 (50%), Gaps = 7/138 (5%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATF---LHQRKMR-SI 285 A Q G+ +LHS I+HRDLK N+ ++ VK+ DFGL L ++K +I Sbjct: 889 AYQASKGMHFLHSS--GIVHRDLKSLNLLLDSK-WNVKVSDFGLTKVKSELDKKKTNDNI 945 Query: 286 KGTLEFMAPELFTGNYNE---LVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT+ ++APE+ + L D+YSFG+ + E++T E PY I G++ Sbjct: 946 IGTIHWIAPEILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMR 1005 Query: 457 PDVLSKVEDAEVRGFIEI 510 P + + A +I++ Sbjct: 1006 PPISDEAVTAHSIEYIDL 1023
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 77.4 bits (189), Expect = 4e-14 Identities = 59/158 (37%), Positives = 84/158 (53%), Gaps = 8/158 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 372 ECLQALEFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 428 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EM+ E PY +Y + G P+ Sbjct: 429 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE 488 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQ 573 LS + R F+ CL V +R A ELL++ FL+ Sbjct: 489 KLSAI----FRDFLNRCLEMDVEKRGSAKELLQHQFLK 522
>TAOK3_RAT (Q53UA7) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Axotomy-related gene 357 protein) Length = 898 Score = 77.0 bits (188), Expect = 5e-14 Identities = 62/195 (31%), Positives = 98/195 (50%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLH ++IHRD+K Sbjct: 96 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHFH--SLIHRDIKA 150 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VDI+S Sbjct: 151 GNILLT-EPGQVKLADFGSASMASPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDIWSL 207 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S+ R F++ CL + ER Sbjct: 208 GITCIELAERKPPLFNMNAMSALY-HIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERP 266 Query: 538 CASELLKNCFLQKDK 582 A+ELL++ F+++++ Sbjct: 267 AAAELLRHDFIRRER 281
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 76.6 bits (187), Expect = 6e-14 Identities = 61/161 (37%), Positives = 84/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L L++LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 370 ECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 426 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 427 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 486 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS V R F+ CL V R A ELL++ FL+ K Sbjct: 487 RLSAV----FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>PLK1_HUMAN (P53350) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) Length = 603 Score = 76.6 bits (187), Expect = 6e-14 Identities = 56/193 (29%), Positives = 99/193 (51%), Gaps = 4/193 (2%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G V ++ ELC SL + K+ + R + QI+ G +YLH +IHR Sbjct: 118 GFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR--VIHR 175 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPELFTGNYNEL-VDI 351 DLK N+F+N D +VKIGDFGLAT + + +++ GT ++APE+ + + VD+ Sbjct: 176 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDV 234 Query: 352 YSFGMCMLEMVTCEYPY-SECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVT 528 +S G M ++ + P+ + C + ++ K ++ P ++ V + ++ ++ T Sbjct: 235 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQ---TDPT 291 Query: 529 ERLCASELLKNCF 567 R +ELL + F Sbjct: 292 ARPTINELLNDEF 304
>E2AK2_HUMAN (P19525) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) Length = 551 Score = 76.6 bits (187), Expect = 6e-14 Identities = 55/154 (35%), Positives = 86/154 (55%), Gaps = 7/154 (4%) Frame = +1 Query: 40 ELCTSGSLRQFRKKHNKVGMKAMRGWAI----QILAGLEYLHSQEPAIIHRDLKCDNIFI 207 E C G+L Q+ +K G K + A+ QI G++Y+HS++ +IHRDLK NIF+ Sbjct: 367 EFCDKGTLEQWIEKRR--GEKLDKVLALELFEQITKGVDYIHSKK--LIHRDLKPSNIFL 422 Query: 208 NGHDGQVKIGDFGLATFL-HQRKMRSIKGTLEFMAPE-LFTGNYNELVDIYSFGMCMLEM 381 QVKIGDFGL T L + K KGTL +M+PE + + +Y + VD+Y+ G+ + E+ Sbjct: 423 VDTK-QVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 481 Query: 382 V-TCEYPYSECQGKPWIYKKISQGIKPDVLSKVE 480 + C+ + + + + GI D+ K E Sbjct: 482 LHVCDTAFETSK----FFTDLRDGIISDIFDKKE 511
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 76.6 bits (187), Expect = 6e-14 Identities = 53/170 (31%), Positives = 83/170 (48%), Gaps = 7/170 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRG----WAIQILAGLEYLHSQEPAIIHRDLKCDN 198 I+ C G L +RK + G W +QI L+YLH E I+HRDLK N Sbjct: 81 IVMGFCEGGDL--YRKLKEQKGQLLPESQVVEWFVQIAMALQYLH--EKHILHRDLKTQN 136 Query: 199 IFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMC 369 +F+ +K+GD G+A L H ++ GT +M+PELF+ YN D+++ G C Sbjct: 137 VFLT-RTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCC 195 Query: 370 MLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLA 519 + EM T ++ ++ +Y+ I + P + KV E+ I L+ Sbjct: 196 VYEMATLKHAFNAKDMNSLVYRIIEGKLPP--MPKVYSTELAELIRTMLS 243
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 76.6 bits (187), Expect = 6e-14 Identities = 41/142 (28%), Positives = 75/142 (52%), Gaps = 1/142 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + +I E G L Q ++ + + + Q+ L YLH + +IHRD+K +NI Sbjct: 162 IYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKH--VIHRDIKPENIL 219 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 + G DG++K+ DFG + + ++ GTL+++ PE+ G + E VD++S G+ E Sbjct: 220 L-GIDGEIKLSDFGWSVHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEF 278 Query: 382 VTCEYPYSECQGKPWIYKKISQ 447 + P+ + G YK+I++ Sbjct: 279 LVGAPPFEDMSGHSATYKRIAK 300
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 76.6 bits (187), Expect = 6e-14 Identities = 45/107 (42%), Positives = 62/107 (57%), Gaps = 9/107 (8%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEPA-IIHRDLKCDNIFI-------NGHDGQVKIGDFGLATFLHQR 270 WA+Q+ G+ YLH+ P IIHRDLK NI I N D +KI DFGLA H+ Sbjct: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258 Query: 271 KMRSIKGTLEFMAPELF-TGNYNELVDIYSFGMCMLEMVTCEYPYSE 408 S GT +MAPE+ +++ D++SFG+ + E++T E PY E Sbjct: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYRE 305
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 76.6 bits (187), Expect = 6e-14 Identities = 61/161 (37%), Positives = 84/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L L++LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 385 ECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 501 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS V R F+ CL V R A ELL++ FL+ K Sbjct: 502 RLSAV----FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 538
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 76.6 bits (187), Expect = 6e-14 Identities = 61/161 (37%), Positives = 84/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L L++LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 385 ECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 501 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS V R F+ CL V R A ELL++ FL+ K Sbjct: 502 RLSAV----FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 538
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 76.6 bits (187), Expect = 6e-14 Identities = 61/161 (37%), Positives = 84/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L L++LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 385 ECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 501 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS V R F+ CL V R A ELL++ FL+ K Sbjct: 502 RLSAV----FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 538
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 76.6 bits (187), Expect = 6e-14 Identities = 61/161 (37%), Positives = 84/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L L++LHS + +IHRD+K DNI + G DG VK+ DFG + Q K ++ GT Sbjct: 385 ECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 501 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS V R F+ CL V R A ELL++ FL+ K Sbjct: 502 RLSAV----FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 538
>NEK6_HUMAN (Q9HC98) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) (Protein kinase SID6-1512) Length = 313 Score = 76.3 bits (186), Expect = 8e-14 Identities = 51/174 (29%), Positives = 89/174 (51%), Gaps = 8/174 (4%) Frame = +1 Query: 25 VNIITELCTSGSLRQ----FRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 +NI+ EL +G L Q F+K+ + + + + +Q+ + +E++HS+ ++HRD+K Sbjct: 118 LNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR--VMHRDIKP 175 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPE-LFTGNYNELVDIYSFG 363 N+FI G VK+GD GL F S+ GT +M+PE + YN DI+S G Sbjct: 176 ANVFITA-TGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLG 234 Query: 364 MCMLEMVTCEYP-YSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP 522 + EM + P Y + + +KI Q P + + ++R + +C+ P Sbjct: 235 CLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICP 288
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 76.3 bits (186), Expect = 8e-14 Identities = 52/145 (35%), Positives = 84/145 (57%), Gaps = 6/145 (4%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + +I ELC SL + +K ++ +R +QIL L+Y+H + +IHRDLK NI Sbjct: 113 IYLILELCEHKSLMELLRKRKQLTEPEVRYLMMQILGALKYMHKKR--VIHRDLKLGNIM 170 Query: 205 INGHDGQVKIGDFGLATFL---HQRKMRSIKGTLEFMAPELFTGN---YNELVDIYSFGM 366 ++ VKIGDFGLA L +RKM +I GT ++APE+ + ++ VD++S G+ Sbjct: 171 LD-ESNNVKIGDFGLAALLMDDEERKM-TICGTPNYIAPEILFNSKEGHSFEVDLWSAGV 228 Query: 367 CMLEMVTCEYPYSECQGKPWIYKKI 441 M ++ + P+ + + K IY+KI Sbjct: 229 VMYALLIGKPPFQDKEVKT-IYRKI 252
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 76.3 bits (186), Expect = 8e-14 Identities = 52/165 (31%), Positives = 89/165 (53%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL + + K M + A Q G++YLH++ IIHRD+K Sbjct: 413 TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 470 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNEL 342 +NIF+ H+G VKIGDFGLAT + +++ G++ +MAPE+ ++ Sbjct: 471 SNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQ 528 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+YS+G+ + E++ E PY+ + I + +G LS++ Sbjct: 529 SDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRL 573
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 76.3 bits (186), Expect = 8e-14 Identities = 50/163 (30%), Positives = 79/163 (48%), Gaps = 18/163 (11%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKV---GMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNI 201 I+TE GSLRQF H + A+ I G+ YLH P I+HRDL NI Sbjct: 1364 IVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNI 1423 Query: 202 FINGH------------DGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTGNYN- 336 ++ + D + KI DFGL+ ++ +M G + +MAPE+F G+ N Sbjct: 1424 LLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQMTQSVGCIPYMAPEVFKGDSNS 1483 Query: 337 ELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDV 465 E D+YS+GM + E++T + P + + + + +P + Sbjct: 1484 EKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPI 1526
>PLK1_XENLA (P70032) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Plx1) Length = 598 Score = 76.3 bits (186), Expect = 8e-14 Identities = 58/193 (30%), Positives = 99/193 (51%), Gaps = 4/193 (2%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G V ++ ELC SL + K+ V R + Q ++G +YLHS +IHR Sbjct: 109 GFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTISGCQYLHSNR--VIHR 166 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPE-LFTGNYNELVDI 351 DLK N+F+N + +VKIGDFGLAT + + +++ GT ++APE L ++ VDI Sbjct: 167 DLKLGNLFLN-DEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDI 225 Query: 352 YSFGMCMLEMVTCEYPY-SECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVT 528 +S G M ++ + P+ + C + ++ K ++ P ++ V A ++ + + T Sbjct: 226 WSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSIPKHINPVAAALIQKMLR---SDPT 282 Query: 529 ERLCASELLKNCF 567 R +LL + F Sbjct: 283 SRPTIDDLLNDEF 295
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 76.3 bits (186), Expect = 8e-14 Identities = 52/165 (31%), Positives = 89/165 (53%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 T+ + I+T+ C SL + + K M + A Q G++YLH++ IIHRD+K Sbjct: 88 TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMK 145 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNEL 342 +NIF+ H+G VKIGDFGLAT + +++ G++ +MAPE+ ++ Sbjct: 146 SNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQ 203 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+YS+G+ + E++ E PY+ + I + +G LS++ Sbjct: 204 SDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRL 248
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 75.9 bits (185), Expect = 1e-13 Identities = 59/171 (34%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GLEYLH IHRD+K NI + G DG V+I DFG++ FL + ++ Sbjct: 129 EVLEGLEYLHKNGQ--IHRDVKAGNILL-GEDGSVQIADFGVSAFLATGGDITRNKVRKT 185 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ DI+SFG+ +E+ T PY + + + Q Sbjct: 186 FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 244 Query: 457 PDVLSKVEDAEV--------RGFIEICLAPVTE-RLCASELLKNCFLQKDK 582 P + + V+D E+ R I +CL E R A+ELL++ F QK K Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 75.9 bits (185), Expect = 1e-13 Identities = 59/171 (34%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GLEYLH IHRD+K NI + G DG V+I DFG++ FL + ++ Sbjct: 129 EVLEGLEYLHKNGQ--IHRDVKAGNILL-GEDGSVQIADFGVSAFLATGGDITRNKVRKT 185 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ DI+SFG+ +E+ T PY + + + Q Sbjct: 186 FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 244 Query: 457 PDVLSKVEDAEV--------RGFIEICLAPVTE-RLCASELLKNCFLQKDK 582 P + + V+D E+ R I +CL E R A+ELL++ F QK K Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 75.9 bits (185), Expect = 1e-13 Identities = 59/171 (34%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GLEYLH IHRD+K NI + G DG V+I DFG++ FL + ++ Sbjct: 129 EVLEGLEYLHKNGQ--IHRDVKAGNILL-GEDGSVQIADFGVSAFLATGGDITRNKVRKT 185 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ DI+SFG+ +E+ T PY + + + Q Sbjct: 186 FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 244 Query: 457 PDVLSKVEDAEV--------RGFIEICLAPVTE-RLCASELLKNCFLQKDK 582 P + + V+D E+ R I +CL E R A+ELL++ F QK K Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
>POLO_DROME (P52304) Serine/threonine-protein kinase polo (EC 2.7.11.21)| Length = 576 Score = 75.9 bits (185), Expect = 1e-13 Identities = 46/129 (35%), Positives = 72/129 (55%), Gaps = 3/129 (2%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + I+ ELC S+ + K+ + R + QI+ G++YLH IIHRDLK N+F Sbjct: 98 IYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNR--IIHRDLKLGNLF 155 Query: 205 INGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPELFTGNYNEL-VDIYSFGMCML 375 +N VKIGDFGLAT + + +++ GT ++APE+ T + VDI+S G M Sbjct: 156 LNDL-LHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMY 214 Query: 376 EMVTCEYPY 402 ++ + P+ Sbjct: 215 TLLVGQPPF 223
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 75.9 bits (185), Expect = 1e-13 Identities = 50/150 (33%), Positives = 82/150 (54%), Gaps = 4/150 (2%) Frame = +1 Query: 136 GLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMR--SIKGTLEFMA 309 GL++LH + IIHRD+K DN+ ++ H G+VKI DFG L ++ + ++ GT +MA Sbjct: 631 GLKFLHDKH--IIHRDIKSDNVLLDTH-GRVKITDFGFCAKLTDKRSKRATMVGTPYWMA 687 Query: 310 PELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDA 486 PE+ Y+E VD++S G+ +EM+ E PY + +Y + G ++ Sbjct: 688 PEVVKQREYDEKVDVWSLGIMTIEMLEGEPPYLNEEPLKALYLIATNGTPKLKHPELLSL 747 Query: 487 EVRGFIEICL-APVTERLCASELLKNCFLQ 573 E++ F+ +CL V R ELL + F + Sbjct: 748 EIKRFLSVCLCVDVRYRASTEELLHHSFFE 777
>KPC4_DROME (P83099) Putative protein kinase C, delta type homolog (EC| 2.7.11.13) Length = 643 Score = 75.9 bits (185), Expect = 1e-13 Identities = 44/137 (32%), Positives = 77/137 (56%), Gaps = 3/137 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T + + E G L ++ + + R + +I++GL++LH + II+RDLK Sbjct: 384 QTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKK--GIIYRDLK 441 Query: 190 CDNIFINGHDGQVKIGDFGLATF--LHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSF 360 DN+ ++ ++G V+I DFG+ + S GT ++MAPE+ G YN+ VD +SF Sbjct: 442 LDNVLLD-YEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSF 500 Query: 361 GMCMLEMVTCEYPYSEC 411 G+ + EM+ + P+S C Sbjct: 501 GVLLYEMLIGQSPFSGC 517
>PLK1_MOUSE (Q07832) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) Length = 603 Score = 75.9 bits (185), Expect = 1e-13 Identities = 55/185 (29%), Positives = 98/185 (52%), Gaps = 4/185 (2%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 V ++ ELC SL + K+ + R + QI+ G +YLH + +IHRDLK N+F Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNQ--VIHRDLKLGNLF 183 Query: 205 INGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPELFTGNYNEL-VDIYSFGMCML 375 +N D +VKIGDFGLAT + + +++ GT ++APE+ + + VD++S G M Sbjct: 184 LN-EDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMY 242 Query: 376 EMVTCEYPY-SECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLCASEL 552 ++ + P+ + C + ++ K ++ P ++ V + ++ ++ T R EL Sbjct: 243 TLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQ---TDPTARPTIHEL 299 Query: 553 LKNCF 567 L + F Sbjct: 300 LNDEF 304
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 75.9 bits (185), Expect = 1e-13 Identities = 59/171 (34%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GLEYLH IHRD+K NI + G DG V+I DFG++ FL + ++ Sbjct: 129 EVLEGLEYLHKNGQ--IHRDVKAGNILL-GEDGSVQIADFGVSAFLATGGDITRNKVRKT 185 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ DI+SFG+ +E+ T PY + + + Q Sbjct: 186 FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 244 Query: 457 PDVLSKVEDAEV--------RGFIEICLAPVTE-RLCASELLKNCFLQKDK 582 P + + V+D E+ R I +CL E R A+ELL++ F QK K Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 75.9 bits (185), Expect = 1e-13 Identities = 62/195 (31%), Positives = 97/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLH ++IHRD+K Sbjct: 96 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHFH--SLIHRDIKA 150 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VDI+S Sbjct: 151 GNILLT-EPGQVKLADFGSASMASPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDIWSL 207 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S+ R F++ CL + ER Sbjct: 208 GITCIELAERKPPLFNMNAMSALY-HIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERP 266 Query: 538 CASELLKNCFLQKDK 582 A ELL++ F+++++ Sbjct: 267 AAVELLRHDFIRRER 281
>PLK1_RAT (Q62673) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) Length = 603 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/137 (33%), Positives = 75/137 (54%), Gaps = 3/137 (2%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G V ++ ELC SL + K+ + R + QI+ G +YLH + +IHR Sbjct: 118 GFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNQ--VIHR 175 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPELFTGNYNEL-VDI 351 DLK N+F+N D +VKIGDFGLAT + + +++ GT ++APE+ + + VD+ Sbjct: 176 DLKLGNLFLN-EDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDV 234 Query: 352 YSFGMCMLEMVTCEYPY 402 +S G M ++ + P+ Sbjct: 235 WSIGCIMYTLLVGKPPF 251
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 75.5 bits (184), Expect = 1e-13 Identities = 44/131 (33%), Positives = 71/131 (54%), Gaps = 6/131 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKV-GMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFI 207 I+T+ + GSL + ++ +++ A+ + G+EYLHS IIHRDL NI + Sbjct: 536 IVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILL 595 Query: 208 NGHDGQVKIGDFGLATFLH---QRKMRSIKGTLEFMAPELFT--GNYNELVDIYSFGMCM 372 DG + DFG + FL + M G L +MAPE+FT Y D++S+ +C+ Sbjct: 596 Y-EDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYSLCL 654 Query: 373 LEMVTCEYPYS 405 E++T E P++ Sbjct: 655 WELLTGEIPFA 665
>NEK6_RAT (P59895) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 75.1 bits (183), Expect = 2e-13 Identities = 51/174 (29%), Positives = 89/174 (51%), Gaps = 8/174 (4%) Frame = +1 Query: 25 VNIITELCTSGSLRQ----FRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 +NI+ EL +G L Q F+K+ + + + + +Q+ + +E++HS+ ++HRD+K Sbjct: 118 LNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR--VMHRDIKP 175 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPE-LFTGNYNELVDIYSFG 363 N+FI G VK+GD GL F S+ GT +M+PE + YN DI+S G Sbjct: 176 ANVFITA-TGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLG 234 Query: 364 MCMLEMVTCEYP-YSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP 522 + EM + P Y + + +KI Q P + + ++R + +C+ P Sbjct: 235 CLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYP 288
>NEK6_MOUSE (Q9ES70) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 75.1 bits (183), Expect = 2e-13 Identities = 51/174 (29%), Positives = 89/174 (51%), Gaps = 8/174 (4%) Frame = +1 Query: 25 VNIITELCTSGSLRQ----FRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 +NI+ EL +G L Q F+K+ + + + + +Q+ + +E++HS+ ++HRD+K Sbjct: 118 LNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR--VMHRDIKP 175 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPE-LFTGNYNELVDIYSFG 363 N+FI G VK+GD GL F S+ GT +M+PE + YN DI+S G Sbjct: 176 ANVFITA-TGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLG 234 Query: 364 MCMLEMVTCEYP-YSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP 522 + EM + P Y + + +KI Q P + + ++R + +C+ P Sbjct: 235 CLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYP 288
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 75.1 bits (183), Expect = 2e-13 Identities = 61/195 (31%), Positives = 95/195 (48%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHSH--TMIHRDIKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLT-EPGQVKLADFGSASMASPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + +R Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRP 270 Query: 538 CASELLKNCFLQKDK 582 + ELLK+ F+ +++ Sbjct: 271 TSEELLKHMFVLRER 285
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 75.1 bits (183), Expect = 2e-13 Identities = 61/195 (31%), Positives = 95/195 (48%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHSH--TMIHRDIKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLT-EPGQVKLADFGSASMASPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + +R Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRP 270 Query: 538 CASELLKNCFLQKDK 582 + ELLK+ F+ +++ Sbjct: 271 TSEELLKHMFVLRER 285
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 75.1 bits (183), Expect = 2e-13 Identities = 61/195 (31%), Positives = 95/195 (48%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHSH--TMIHRDIKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLT-EPGQVKLADFGSASMASPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + +R Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRP 270 Query: 538 CASELLKNCFLQKDK 582 + ELLK+ F+ +++ Sbjct: 271 TSEELLKHIFVLRER 285
>TAO1A_XENLA (Q6NU21) Serine/threonine-protein kinase TAO1-A (EC 2.7.11.1)| (Thousand and one amino acid protein 1-A) Length = 1001 Score = 75.1 bits (183), Expect = 2e-13 Identities = 61/191 (31%), Positives = 92/191 (48%), Gaps = 8/191 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K ++ + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEIEIAAITHGALQ---GLAYLHSHN--LIHRDIKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLT-EPGQVKLADFGSASIASPAN--SFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + +R Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPTLQSNEWSDFFRNFVDSCLQKIPQDRP 270 Query: 538 CASELLKNCFL 570 + ELLKN F+ Sbjct: 271 TSDELLKNMFV 281
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/144 (34%), Positives = 82/144 (56%), Gaps = 5/144 (3%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 V I+ E+C +GSL + K+ + +R + QI ++Y+HS+ +IHRDLK NIF Sbjct: 154 VYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRR--VIHRDLKLGNIF 211 Query: 205 INGHDGQVKIGDFGLATFLHQRKMR--SIKGTLEFMAPELFTGNYNE---LVDIYSFGMC 369 + + +KIGDFGLA L R +I GT ++APE+ G ++ VDI+S G+ Sbjct: 212 FDS-NYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVM 270 Query: 370 MLEMVTCEYPYSECQGKPWIYKKI 441 + ++ + P+ + + IY++I Sbjct: 271 LYALLIGKPPF-QARDVNTIYERI 293
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 75.1 bits (183), Expect = 2e-13 Identities = 57/190 (30%), Positives = 96/190 (50%), Gaps = 10/190 (5%) Frame = +1 Query: 28 NIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFI 207 ++ E GS+ + + + ++ Q+L GL YLHS+ I+HRD+K DN+ + Sbjct: 1254 SLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSK--GILHRDMKADNLLL 1311 Query: 208 NGHDGQVKIGDFGLATF---LHQRKMRSIKGTLEFMAPELFTGN--YNELVDIYSFGMCM 372 + DG KI DFG++ ++ +++GT+ +MAPE+ Y+ VDI+S G + Sbjct: 1312 D-QDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIV 1370 Query: 373 LEMVTCEYPYSECQGKPWIYK----KISQGIKPDVLSKVEDAEVRGFIEICLAPVTE-RL 537 LEM + P+S + ++K K + I D L + R F++ C E R Sbjct: 1371 LEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIG-RNFLDACFEINPEKRP 1429 Query: 538 CASELLKNCF 567 A+ELL + F Sbjct: 1430 TANELLSHPF 1439
>GCN2_YEAST (P15442) Serine/threonine-protein kinase GCN2 (EC 2.7.11.1)| Length = 1590 Score = 75.1 bits (183), Expect = 2e-13 Identities = 58/165 (35%), Positives = 83/165 (50%), Gaps = 20/165 (12%) Frame = +1 Query: 7 MRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAI--QILAGLEYLHSQEPAIIHR 180 ++ + T+ I E C + +L N + + W + QIL L Y+HSQ IIHR Sbjct: 709 VKKKSTLFIQMEYCENRTLYDLIHSEN-LNQQRDEYWRLFRQILEALSYIHSQ--GIIHR 765 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQR----------------KMRSIKGTLEFMAP 312 DLK NIFI+ VKIGDFGLA +H+ + S GT ++A Sbjct: 766 DLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIGTAMYVAT 824 Query: 313 ELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKI 441 E+ TG+YNE +D+YS G+ EM+ YP+S + I KK+ Sbjct: 825 EVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKKL 866 Score = 35.4 bits (80), Expect = 0.15 Identities = 31/142 (21%), Positives = 59/142 (41%), Gaps = 21/142 (14%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + ++TE C L + V + R W I++L GLE +H + I+H+ + + + Sbjct: 274 IRLLTEYCNYYPLGDLIQSVGFVNLATARIWMIRLLEGLEAIH--KLGIVHKCINLETVI 331 Query: 205 INGHDGQVKIGDFG--LATFLHQRKMRSIKGTLE----------------FMAPELFTGN 330 + VK DFG + +H ++ L ++APEL N Sbjct: 332 L------VKDADFGSTIPKLVHSTYGYTVLNMLSRYPNKNGSSVELSPSTWIAPELLKFN 385 Query: 331 Y---NELVDIYSFGMCMLEMVT 387 L DI+ G+ +++++ Sbjct: 386 NAKPQRLTDIWQLGVLFIQIIS 407
>PLK1_XENTR (P62205) Serine/threonine-protein kinase PLK1 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-1) (Plx1) Length = 598 Score = 75.1 bits (183), Expect = 2e-13 Identities = 57/193 (29%), Positives = 98/193 (50%), Gaps = 4/193 (2%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G V ++ ELC SL + K+ V R + Q + G +YLHS +IHR Sbjct: 109 GFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTILGCQYLHSNR--VIHR 166 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPE-LFTGNYNELVDI 351 DLK N+F+N + +VKIGDFGLAT + + +++ GT ++APE L ++ VDI Sbjct: 167 DLKLGNLFLN-DEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDI 225 Query: 352 YSFGMCMLEMVTCEYPY-SECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVT 528 +S G M ++ + P+ + C + ++ K ++ P ++ + A ++ + + T Sbjct: 226 WSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSVPKHINPMATALIQKMLR---SEPT 282 Query: 529 ERLCASELLKNCF 567 R +LL + F Sbjct: 283 SRPTIDDLLNDEF 295
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 75.1 bits (183), Expect = 2e-13 Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LH+ + +IHRD+K DN+ + G +G VK+ DFG + Q K ++ GT Sbjct: 351 ECLQALEFLHANQ--VIHRDIKSDNVLL-GMEGSVKLTDFGFCAQITPEQSKRSTMVGTP 407 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 408 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 467 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS + R F+ CL V +R A ELL++ FL+ K Sbjct: 468 KLSPI----FRDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 504
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 75.1 bits (183), Expect = 2e-13 Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LH+ + +IHRD+K DN+ + G +G VK+ DFG + Q K ++ GT Sbjct: 351 ECLQALEFLHANQ--VIHRDIKSDNVLL-GMEGSVKLTDFGFCAQITPEQSKRSTMVGTP 407 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 408 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 467 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS + R F+ CL V +R A ELL++ FL+ K Sbjct: 468 KLSPI----FRDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 504
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 75.1 bits (183), Expect = 2e-13 Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LH+ + +IHRD+K DN+ + G +G VK+ DFG + Q K ++ GT Sbjct: 351 ECLQALEFLHANQ--VIHRDIKSDNVLL-GMEGSVKLTDFGFCAQITPEQSKRSTMVGTP 407 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 408 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 467 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS + R F+ CL V +R A ELL++ FL+ K Sbjct: 468 KLSPI----FRDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 504
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 75.1 bits (183), Expect = 2e-13 Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTL 297 + L LE+LH+ + +IHRD+K DN+ + G +G VK+ DFG + Q K ++ GT Sbjct: 351 ECLQALEFLHANQ--VIHRDIKSDNVLL-GMEGSVKLTDFGFCAQITPEQSKRSTMVGTP 407 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ T Y VDI+S G+ +EMV E PY +Y + G P+ Sbjct: 408 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 467 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFLQKDK 582 LS + R F+ CL V +R A ELL++ FL+ K Sbjct: 468 KLSPI----FRDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 504
>TAOK3_XENLA (Q6DD27) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 896 Score = 75.1 bits (183), Expect = 2e-13 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 96 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHSHN--MIHRDIKA 150 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ +DI+S Sbjct: 151 GNILLT-EPGQVKLADFGSAS--KSSPANSFVGTPYWMAPEVILAMDEGQYDGKIDIWSL 207 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S +GF++ CL + ER Sbjct: 208 GITCIELAERKPPLFNMNAMSALY-HIAQNESPTLQSNEWTDSFKGFVDYCLQKLPQERP 266 Query: 538 CASELLKNCFLQKDK 582 + ELL++ F+ +++ Sbjct: 267 ASLELLRHDFVWRER 281
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 75.1 bits (183), Expect = 2e-13 Identities = 48/138 (34%), Positives = 77/138 (55%), Gaps = 5/138 (3%) Frame = +1 Query: 25 VNIITELCTSGSL----RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 +NI E C +GSL ++ R + + G + + A +L+GL YLH ++ IIHRD+K Sbjct: 152 LNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRK--IIHRDIKP 209 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT-GNYNELVDIYSFGMC 369 NI + GQVK+ DFG++ L + GT +MAPE + G+Y DI+S G+ Sbjct: 210 SNILLTSK-GQVKLCDFGVSGELVNSLAGTFTGTSYYMAPERISGGSYTISSDIWSLGLT 268 Query: 370 MLEMVTCEYPYSECQGKP 423 ++E+ +P+ +G P Sbjct: 269 LMEVALNRFPFPP-EGSP 285
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 74.7 bits (182), Expect = 2e-13 Identities = 54/156 (34%), Positives = 86/156 (55%), Gaps = 4/156 (2%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTL 297 +IL GL+YLHS++ IHRD+K N+ ++ H G+VK+ DFG+A L Q K + GT Sbjct: 139 EILKGLDYLHSEKK--IHRDIKAANVLLSEH-GEVKLADFGVAGQLTDTQIKRNTFVGTP 195 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSK 474 +MAPE+ + Y+ DI+S G+ +E+ E P+SE ++ + P L Sbjct: 196 FWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLF--LIPKNNPPTLEG 253 Query: 475 VEDAEVRGFIEICL-APVTERLCASELLKNCFLQKD 579 ++ F+E CL + R A ELLK+ F+ ++ Sbjct: 254 NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 289
>TAO1B_XENLA (Q7ZYJ0) Serine/threonine-protein kinase TAO1-B (EC 2.7.11.1)| (Thousand and one amino acid protein 1-B) Length = 1001 Score = 74.7 bits (182), Expect = 2e-13 Identities = 60/195 (30%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K ++ + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEIEIAAITHGALQ---GLAYLHSHN--LIHRDIKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELF----TGNYNELVDIYSF 360 NI + GQVK+ DFG A+ + S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLT-EPGQVKLADFGSASIV--SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + +R Sbjct: 212 GITCVELAERKPPLFNMNAMSALY-HIAQNESPTLQSTEWSDYFRNFVDSCLHKIPQDRP 270 Query: 538 CASELLKNCFLQKDK 582 + ELLK+ F+ +++ Sbjct: 271 TSDELLKHMFVLRER 285
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 74.7 bits (182), Expect = 2e-13 Identities = 55/156 (35%), Positives = 78/156 (50%), Gaps = 16/156 (10%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E + G L F H VG A R + QIL ++Y+HS I HRDLK DNI I Sbjct: 271 MVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM--GISHRDLKPDNILIE 328 Query: 211 GHDG-QVKIGDFGLATFLHQRK-MRSIKGTLEFMAPELFTG--------------NYNEL 342 D VKI DFGLA M++ GTL ++APE+ G Y+ L Sbjct: 329 QDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSL 388 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG 450 VD++S G + ++T P+S + +YK+I +G Sbjct: 389 VDMWSMGCLVYVILTGHLPFSG-STQDQLYKQIGRG 423
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 74.3 bits (181), Expect = 3e-13 Identities = 45/126 (35%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK K+ K + +I ++ GL YL + I+HRD+K NI Sbjct: 138 ISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNIL 196 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 197 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 255 Query: 382 VTCEYP 399 YP Sbjct: 256 AIGRYP 261
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 74.3 bits (181), Expect = 3e-13 Identities = 54/153 (35%), Positives = 84/153 (54%), Gaps = 4/153 (2%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTL 297 +IL GL+YLHS++ IHRD+K N+ ++ H G+VK+ DFG+A L Q K + GT Sbjct: 127 EILKGLDYLHSEKK--IHRDIKAANVLLSEH-GEVKLADFGVAGQLTDTQIKRNTFVGTP 183 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSK 474 +MAPE+ + Y+ DI+S G+ +E+ E P+SE ++ + P L Sbjct: 184 FWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLF--LIPKNNPPTLEG 241 Query: 475 VEDAEVRGFIEICL-APVTERLCASELLKNCFL 570 ++ F+E CL + R A ELLK+ F+ Sbjct: 242 NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 73.9 bits (180), Expect = 4e-13 Identities = 47/135 (34%), Positives = 74/135 (54%), Gaps = 9/135 (6%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKK---HNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 ++I+TE + GSL + K ++ + A + G+ YLH++ P I+HRDLK Sbjct: 621 LSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSP 680 Query: 196 NIFINGHDGQVKIGDFGL-----ATFLHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYS 357 N+ ++ VK+ DFGL +TFL +S GT E+MAPE+ NE D+YS Sbjct: 681 NLLVD-KKYTVKVCDFGLSRLKASTFL---SSKSAAGTPEWMAPEVLRDEPSNEKSDVYS 736 Query: 358 FGMCMLEMVTCEYPY 402 FG+ + E+ T + P+ Sbjct: 737 FGVILWELATLQQPW 751
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 73.9 bits (180), Expect = 4e-13 Identities = 43/131 (32%), Positives = 71/131 (54%), Gaps = 6/131 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKV-GMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFI 207 I+T+ + GSL + ++ +++ A+ + G+EYLH+ IIHRDL NI + Sbjct: 638 IVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILL 697 Query: 208 NGHDGQVKIGDFGLATFLH---QRKMRSIKGTLEFMAPELFT--GNYNELVDIYSFGMCM 372 DG + DFG + FL + M G L +MAPE+FT Y D++S+ +C+ Sbjct: 698 Y-EDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCL 756 Query: 373 LEMVTCEYPYS 405 E++T E P++ Sbjct: 757 WEILTGEIPFA 767
>TAOK3_PONPY (Q5R4F3) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 73.9 bits (180), Expect = 4e-13 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+ GL YLHS A+IHRD+K Sbjct: 96 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALH---GLAYLHSH--ALIHRDIKA 150 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELF----TGNYNELVDIYSF 360 NI + GQVK+ DFG A+ S GT +MAPE+ G Y+ VD++S Sbjct: 151 GNILLT-EPGQVKLADFGSASV--ASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 207 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + +Y I+Q P + S R F++ CL + ER Sbjct: 208 GITCIELAERKPALFNMNAMSALY-HIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERP 266 Query: 538 CASELLKNCFLQKDK 582 ++ELL++ F+++D+ Sbjct: 267 TSAELLRHDFVRRDR 281
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 73.6 bits (179), Expect = 5e-13 Identities = 58/171 (33%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GL+YLH IHRDLK NI + G DG V+I DFG++ FL + ++ Sbjct: 184 EVLEGLDYLHRNGQ--IHRDLKAGNILL-GEDGSVQIADFGVSAFLATGGDVTRNKVRKT 240 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ D++SFG+ +E+ T PY + + + Q Sbjct: 241 FVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 299 Query: 457 PDVLSKVEDAEV--------RGFIEICL-APVTERLCASELLKNCFLQKDK 582 P + + VED E+ R + +CL ++R A+ELLK F QK K Sbjct: 300 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 350
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 73.6 bits (179), Expect = 5e-13 Identities = 58/171 (33%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GL+YLH IHRDLK NI + G DG V+I DFG++ FL + ++ Sbjct: 187 EVLEGLDYLHRNGQ--IHRDLKAGNILL-GEDGSVQIADFGVSAFLATGGDVTRNKVRKT 243 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ D++SFG+ +E+ T PY + + + Q Sbjct: 244 FVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 302 Query: 457 PDVLSKVEDAEV--------RGFIEICL-APVTERLCASELLKNCFLQKDK 582 P + + VED E+ R + +CL ++R A+ELLK F QK K Sbjct: 303 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 353
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 73.6 bits (179), Expect = 5e-13 Identities = 58/171 (33%), Positives = 87/171 (50%), Gaps = 18/171 (10%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL-------HQRKMRS 282 ++L GL+YLH IHRDLK NI + G DG V+I DFG++ FL + ++ Sbjct: 177 EVLEGLDYLHRNGQ--IHRDLKAGNILL-GEDGSVQIADFGVSAFLATGGDVTRNKVRKT 233 Query: 283 IKGTLEFMAPELF--TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIK 456 GT +MAPE+ Y+ D++SFG+ +E+ T PY + + + Q Sbjct: 234 FVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTL-QNDP 292 Query: 457 PDVLSKVEDAEV--------RGFIEICL-APVTERLCASELLKNCFLQKDK 582 P + + VED E+ R + +CL ++R A+ELLK F QK K Sbjct: 293 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 343
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 73.6 bits (179), Expect = 5e-13 Identities = 47/143 (32%), Positives = 77/143 (53%), Gaps = 3/143 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E G + + H K+ K R + QI + L YLH +++HRDLK +NI I+ Sbjct: 218 MVFEFVDGGQMLDYIISHGKLKEKQARKFVRQIGSALSYLHQN--SVVHRDLKIENILIS 275 Query: 211 GHDGQVKIGDFGLAT-FLHQRKMRSIKGTLEFMAPELFTGN--YNELVDIYSFGMCMLEM 381 G +KI DFGL+ + Q ++R+ G+L F APEL VD++SFG+ + + Sbjct: 276 -KTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVDVWSFGIVLYVL 334 Query: 382 VTCEYPYSECQGKPWIYKKISQG 450 V + P+ + Q ++ KI +G Sbjct: 335 VCGKVPFDD-QNMSALHAKIKKG 356
>ZYG1_CAEEL (Q9GT24) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 706 Score = 73.6 bits (179), Expect = 5e-13 Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 4/127 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I+ ELC GSL+ + ++H + Q+++ + ++H +IHRDL N+FI Sbjct: 83 IVMELCEGGSLQAYVREHGALDDATAVHVLRQLISAVSFMHRVN--VIHRDLSAGNVFIK 140 Query: 211 GHDGQ---VKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGNYNELVDIYSFGMCMLE 378 + VK+GDFGLAT L + + +I GT F+AP+++ Y + D+YS G + Sbjct: 141 DSKKKKMTVKLGDFGLATTLGRGETTCTIVGTPGFIAPQVYDQEYTQSADVYSLGAVLYT 200 Query: 379 MVTCEYP 399 M+T P Sbjct: 201 MLTARNP 207
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 73.2 bits (178), Expect = 7e-13 Identities = 55/165 (33%), Positives = 84/165 (50%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 TR IIT+ C SL + M + A Q G++YLH++ IIHRDLK Sbjct: 374 TRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKN--IIHRDLK 431 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNEL 342 +NIF+ H+G VKIGDFGLAT + + + G++ +MA E+ Y+ Sbjct: 432 SNNIFL--HEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQ 489 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y++G+ + E++T PYS + I + +G LSK+ Sbjct: 490 SDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKI 534
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 73.2 bits (178), Expect = 7e-13 Identities = 43/131 (32%), Positives = 70/131 (53%), Gaps = 6/131 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKV-GMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFI 207 I+T+ + GSL + ++ +++ A+ + G+EYLHS IIHRDL NI + Sbjct: 535 IVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILL 594 Query: 208 NGHDGQVKIGDFGLATFLH---QRKMRSIKGTLEFMAPELFT--GNYNELVDIYSFGMCM 372 DG + DFG + FL + M G L +MAPE+FT Y D++S+ +C+ Sbjct: 595 Y-EDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCL 653 Query: 373 LEMVTCEYPYS 405 E++ E P++ Sbjct: 654 WELLIGEIPFA 664
>KPC1_CAEEL (P34722) Protein kinase C-like 1 (EC 2.7.11.13) (PKC)| (Tetradecanoyl phorbol acetate resistant protein 1) Length = 704 Score = 73.2 bits (178), Expect = 7e-13 Identities = 44/135 (32%), Positives = 74/135 (54%), Gaps = 4/135 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T + + E G L ++ K R +A +I+ L++LH+ II+RDLK Sbjct: 444 QTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNN--IIYRDLK 501 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQRK---MRSIKGTLEFMAPELFTGN-YNELVDIYS 357 DN+ ++ DG +K+ DFG+A R+ + GT ++++PE+ G YNE VD +S Sbjct: 502 LDNVLLDC-DGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWS 560 Query: 358 FGMCMLEMVTCEYPY 402 FG+ M EM+ + P+ Sbjct: 561 FGVLMYEMLVGQSPF 575
>PMYT1_DROME (Q9NI63) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) (dMyt1) Length = 533 Score = 73.2 bits (178), Expect = 7e-13 Identities = 50/180 (27%), Positives = 90/180 (50%), Gaps = 2/180 (1%) Frame = +1 Query: 40 ELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHD 219 ELC SL Q+ + ++ + + + +L GL+ LH + +IH D+K DN+ I D Sbjct: 180 ELCRE-SLEQYLLRCQRIPEERIWHILLDLLRGLKSLHDRN--LIHLDIKLDNVLIGEDD 236 Query: 220 GQVKIGDFGLATFLHQRKMR-SIKGTLEFMAPELFTGNYNELVDIYSFGMCMLEMVTCEY 396 K+ DFGL + + + +G +MAPE+ G++++ DI+S G+ MLE+ Sbjct: 237 ETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELAC--- 293 Query: 397 PYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLCASELLKNCFLQ 573 Y + ++ ++ GI P+ E++ I+ + P +R A +LL + LQ Sbjct: 294 -YMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQ 352
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 73.2 bits (178), Expect = 7e-13 Identities = 55/165 (33%), Positives = 84/165 (50%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 TR IIT+ C SL + M + A Q G++YLH++ IIHRDLK Sbjct: 372 TRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKN--IIHRDLK 429 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNEL 342 +NIF+ H+G VKIGDFGLAT + + + G++ +MA E+ Y+ Sbjct: 430 SNNIFL--HEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQ 487 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y++G+ + E++T PYS + I + +G LSK+ Sbjct: 488 SDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKI 532
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 73.2 bits (178), Expect = 7e-13 Identities = 55/165 (33%), Positives = 84/165 (50%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 TR IIT+ C SL + M + A Q G++YLH++ IIHRDLK Sbjct: 372 TRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKN--IIHRDLK 429 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNEL 342 +NIF+ H+G VKIGDFGLAT + + + G++ +MA E+ Y+ Sbjct: 430 SNNIFL--HEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQ 487 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y++G+ + E++T PYS + I + +G LSK+ Sbjct: 488 SDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKI 532
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 73.2 bits (178), Expect = 7e-13 Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 10/171 (5%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKV----GMKAMRGWAIQILAGLEYLHSQEPA 168 G+ + +I E GSL F H KV + WA Q GL YLH+ P Sbjct: 77 GISSYQQATYLIMEFAEGGSLHNFL--HGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPK 134 Query: 169 -IIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN-YNEL 342 +IHRD+K N+ + +KI DFG M + +G+ +MAPE+F G+ Y E Sbjct: 135 PLIHRDVKPLNLLLTNKGRNLKICDFGTVAD-KSTMMTNNRGSAAWMAPEVFEGSKYTEK 193 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLS----KVED 483 DI+S+ + + E+++ + P+ I KI +G +P +L+ ++ED Sbjct: 194 CDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIED 244
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 72.8 bits (177), Expect = 9e-13 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + I ELC+ SL K + + +R + QIL+GL+YLH + I+HRDLK N F Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR--GILHRDLKLGNFF 192 Query: 205 INGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPE-LFTGNYNELVDIYSFGMCML 375 I + ++K+GDFGLA L +++ ++I GT ++APE L + D++S G C++ Sbjct: 193 IT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLG-CVM 250 Query: 376 EMVTCEYPYSECQGKPWIYKKISQ 447 + C P E Y+ I Q Sbjct: 251 YTLLCGSPPFETADLKETYRCIKQ 274
>DSOR1_DROME (Q24324) Dual specificity mitogen-activated protein kinase kinase| dSOR1 (EC 2.7.12.2) (Downstream of RAF) (MAPKK) Length = 396 Score = 72.8 bits (177), Expect = 9e-13 Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 27/211 (12%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL K+ ++ + + +L GL YL AIIHRD+K NI Sbjct: 158 ISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNH-AIIHRDVKPSNIL 216 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++KI DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 217 VNS-SGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEM 275 Query: 382 VTCEYPY---------------SECQGKPW-------IYKKISQGIK---PDVLSKVEDA 486 YP +E G+P I++ + + P + K+ Sbjct: 276 AIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFST 335 Query: 487 EVRGFIEICL-APVTERLCASELLKNCFLQK 576 E + F++ICL ER LL + +++K Sbjct: 336 EFKDFVDICLKKQPDERADLKTLLSHPWIRK 366
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 72.8 bits (177), Expect = 9e-13 Identities = 60/195 (30%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K ++ + A+ A+Q GL YLH+ +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEMEIAAITHGALQ---GLAYLHNHN--MIHRDVKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI + G VK+GDFG A+ + S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLT-EPGLVKLGDFGSASIM--APANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPV-TERL 537 G+ +E+ + P +Y I+Q P + S R F++ CL + +R Sbjct: 212 GITSIELAERKPPLFNMNAMSALY-HIAQNESPVLQSNHWSEYFRNFVDSCLQKIPQDRP 270 Query: 538 CASELLKNCFLQKDK 582 + LLK+ FLQ+++ Sbjct: 271 TSDMLLKHRFLQRER 285
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 72.8 bits (177), Expect = 9e-13 Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 7/144 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRG----WAIQILAGLEYLHSQEPAIIHRDLKCDN 198 I+ C G L +RK + G W +QI L+YLH E I+HRDLK N Sbjct: 81 IVMGFCEGGDL--YRKLKEQKGQLLPENQVVEWFVQIAMALQYLH--EKHILHRDLKTQN 136 Query: 199 IFINGHDGQVKIGDFGLATFL--HQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMC 369 +F+ +K+GD G+A L H ++ GT +M+PELF+ YN D+++ G C Sbjct: 137 VFLT-RTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCC 195 Query: 370 MLEMVTCEYPYSECQGKPWIYKKI 441 + EM T ++ ++ +Y+ I Sbjct: 196 VYEMATLKHAFNAKDMNSLVYRII 219
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 72.8 bits (177), Expect = 9e-13 Identities = 44/134 (32%), Positives = 72/134 (53%), Gaps = 1/134 (0%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G+ + ++I E GSL Q KK ++ + + +I ++ GL YL + I+HR Sbjct: 131 GVFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHR 189 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYS 357 D+K NI +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S Sbjct: 190 DVKPSNILVNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWS 248 Query: 358 FGMCMLEMVTCEYP 399 G+ ++EM YP Sbjct: 249 MGLSLVEMAVGRYP 262
>NEK3_MOUSE (Q9R0A5) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) Length = 511 Score = 72.8 bits (177), Expect = 9e-13 Identities = 55/198 (27%), Positives = 91/198 (45%), Gaps = 22/198 (11%) Frame = +1 Query: 31 IITELCTSGSLRQFRK--KHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 I+ E C G L Q K K N + W IQI G+ ++H + ++HRD+K N+F Sbjct: 75 IVMEYCDGGDLMQRIKQQKGNLFPEDTILNWFIQICLGVNHIHKRR--VLHRDIKSKNVF 132 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIK--GTLEFMAPELFTG-NYNELVDIYSFGMCML 375 + H+G+VK+GDFG A L + GT ++ PE++ YN DI+S G + Sbjct: 133 LT-HNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILY 191 Query: 376 EMVTCEYPYSE----------CQGK----PWIYKKISQGIKPDVLSKVEDAEVRGFIEIC 513 E+ ++P+ CQG P +Y QG+ +L + +C Sbjct: 192 ELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLC 251 Query: 514 ---LAPVTERLCASELLK 558 LAP+ + ++++ Sbjct: 252 RGSLAPLVPKCLPPQIIR 269
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + I ELC+ SL K + + +R + QIL+GL+YLH + I+HRDLK N F Sbjct: 104 IYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR--GILHRDLKLGNFF 161 Query: 205 INGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPE-LFTGNYNELVDIYSFGMCML 375 I + ++K+GDFGLA L +++ ++I GT ++APE L + D++S G C++ Sbjct: 162 IT-DNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLG-CVM 219 Query: 376 EMVTCEYPYSECQGKPWIYKKISQ 447 + C P E Y+ I Q Sbjct: 220 YTLLCGSPPFETADLKETYRCIKQ 243
>M4K1_HUMAN (Q92918) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) Length = 833 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/170 (31%), Positives = 83/170 (48%), Gaps = 8/170 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I E C +GSL+ + + + ++L GL YLHSQ+ IHRD+K NI IN Sbjct: 89 ICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK--IHRDIKGANILIN 146 Query: 211 GHDGQVKIGDFGLATFLHQRKMRSIK--GTLEFMAPEL----FTGNYNELVDIYSFGMCM 372 G+V++ DFG++ + R + GT +MAPE+ G YNEL DI+S G+ Sbjct: 147 DA-GEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITA 205 Query: 373 LEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVE--DAEVRGFIEICL 516 +E+ + P + ++ G +P L + A FI++ L Sbjct: 206 IELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTL 255
>PLK3_MOUSE (Q60806) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) Length = 631 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + I ELC+ SL K + + +R + QIL+GL+YLH + I+HRDLK N F Sbjct: 136 IYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR--GILHRDLKLGNFF 193 Query: 205 INGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPE-LFTGNYNELVDIYSFGMCML 375 I + ++K+GDFGLA L +++ ++I GT ++APE L + D++S G C++ Sbjct: 194 IT-DNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLG-CVM 251 Query: 376 EMVTCEYPYSECQGKPWIYKKISQ 447 + C P E Y+ I Q Sbjct: 252 YTLLCGSPPFETADLKETYRCIKQ 275
>RIPK5_CHICK (Q6XUX0) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/138 (34%), Positives = 73/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ YLHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 759 ALDVVEGIRYLHSQ--GLVHRDIKLKNVLLDKKN-RAKITDLG---FCKPEAMMSGSIVG 812 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + C K ++ + +G++P Sbjct: 813 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHVKLPEAFERCASKDHLWNNVRRGVRP 872 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L V D E +E C Sbjct: 873 ERL-PVFDEECWQLMEAC 889
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 72.0 bits (175), Expect = 1e-12 Identities = 57/196 (29%), Positives = 100/196 (51%), Gaps = 6/196 (3%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G +R ++NI+ E GS+ +K + + Q+L GLEYLH+ I+HR Sbjct: 138 GTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNN--GIMHR 195 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPE-LFTGNYNELV 345 D+K NI ++ + G +++ DFG + + + +S+KGT +MAPE + ++ Sbjct: 196 DIKGANILVD-NKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHSFSA 254 Query: 346 DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICL-AP 522 DI+S G ++EM T + P+SE + I + + + E + F+ CL Sbjct: 255 DIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKCLHKE 314 Query: 523 VTERLCASELLKNCFL 570 + RL A+ELL++ F+ Sbjct: 315 PSLRLSATELLQHPFV 330
>TAOK2_MOUSE (Q6ZQ29) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1055 Score = 72.0 bits (175), Expect = 1e-12 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHN--MIHRDVKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI ++ G VK+GDFG A+ + S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLS-EPGLVKLGDFGSASIM--APANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLC 540 G+ +E+ + P +Y I+Q P + S R F++ CL + + Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRP 270 Query: 541 ASE-LLKNCFLQKDK 582 SE LLK+ F+ +++ Sbjct: 271 TSEVLLKHRFVLRER 285
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 72.0 bits (175), Expect = 1e-12 Identities = 55/165 (33%), Positives = 84/165 (50%), Gaps = 10/165 (6%) Frame = +1 Query: 13 TRXTVNIITELCTSGSL-RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 TR IIT+ C SL + M + A Q G++YLH++ IIHRDLK Sbjct: 374 TRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKN--IIHRDLK 431 Query: 190 CDNIFINGHDG-QVKIGDFGLATFLHQ----RKMRSIKGTLEFMAPELFT----GNYNEL 342 +NIF+ H+G VKIGDFGLAT + + + G++ +MA E+ Y+ Sbjct: 432 SNNIFL--HEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQ 489 Query: 343 VDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 D+Y++G+ + E++T PYS + I + +G LSK+ Sbjct: 490 SDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKI 534
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 72.0 bits (175), Expect = 1e-12 Identities = 57/161 (35%), Positives = 80/161 (49%), Gaps = 8/161 (4%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTL 297 QIL GL YLH I+HRD+K DN+ IN G +KI DFG + L + GTL Sbjct: 477 QILQGLGYLHDNH--IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTL 534 Query: 298 EFMAPELF---TGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPW--IYKKISQGIKPD 462 ++MAPE+ Y + DI+S G ++EM T P+ E G P +++ + P Sbjct: 535 QYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHEL-GSPQAAMFQVGMYKVHPP 593 Query: 463 VLSKVEDAEVRGFIEICLAPVTE-RLCASELLKNCFLQKDK 582 + S + AE + F+ P R A LL + FLQ K Sbjct: 594 MPSSL-SAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGK 633
>NEK1_CAEEL (P84199) Serine/threonine-protein kinase D1044.8 (EC 2.7.11.1)| Length = 959 Score = 72.0 bits (175), Expect = 1e-12 Identities = 57/169 (33%), Positives = 85/169 (50%), Gaps = 5/169 (2%) Frame = +1 Query: 31 IITELCTSGSLRQF--RKKHNKVGMKAMRGWA--IQILAGLEYLHSQEPAIIHRDLKCDN 198 I+ +L SLR K K + + WA +Q++ L YLH +E I+HRDLK +N Sbjct: 516 IVMDLIQGCSLRDLIITMKEKKGNFEEKKIWAMVVQMMLALRYLH-KEKQIVHRDLKPNN 574 Query: 199 IFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCML 375 I + D +V I DFGLA ++S GT+ + PE+ Y E DI+SFG C+ Sbjct: 575 IMMTT-DERVVITDFGLAKQKGPEYLKSAAGTIIYSCPEIVQNLPYGEKADIWSFGCCIY 633 Query: 376 EMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP 522 EM + P + +I + K D L+++ ++R I CLAP Sbjct: 634 EMCQLQ-PVFHSTNMLTLAMQIVEA-KYDPLNEMWSDDLRFLITSCLAP 680
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK ++ + + +I ++ GL YL + I+HRD+K NI Sbjct: 138 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNIL 196 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 197 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 255 Query: 382 VTCEYP 399 YP Sbjct: 256 AVGRYP 261
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK ++ + + +I ++ GL YL + I+HRD+K NI Sbjct: 138 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNIL 196 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 197 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 255 Query: 382 VTCEYP 399 YP Sbjct: 256 AVGRYP 261
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK ++ + + +I ++ GL YL + I+HRD+K NI Sbjct: 138 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNIL 196 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 197 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 255 Query: 382 VTCEYP 399 YP Sbjct: 256 AVGRYP 261
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK ++ + + +I ++ GL YL + I+HRD+K NI Sbjct: 138 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNIL 196 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 197 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 255 Query: 382 VTCEYP 399 YP Sbjct: 256 AVGRYP 261
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 72.0 bits (175), Expect = 1e-12 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHN--MIHRDVKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI ++ G VK+GDFG A+ + S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLS-EPGLVKLGDFGSASIM--APANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLC 540 G+ +E+ + P +Y I+Q P + S R F++ CL + + Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRP 270 Query: 541 ASE-LLKNCFLQKDK 582 SE LLK+ F+ +++ Sbjct: 271 TSEVLLKHRFVLRER 285
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 71.6 bits (174), Expect = 2e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK ++ + + +I ++ GL YL + I+HRD+K NI Sbjct: 132 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNIL 190 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++EM Sbjct: 191 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 249 Query: 382 VTCEYP 399 YP Sbjct: 250 AIGRYP 255
>PLK1_CAEEL (P34331) Serine/threonine-protein kinase plk-1 (EC 2.7.11.21)| (Polo-like kinase 1) Length = 649 Score = 71.6 bits (174), Expect = 2e-12 Identities = 51/141 (36%), Positives = 77/141 (54%), Gaps = 2/141 (1%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 V I ELC SL + K+ V R + QI+ G+ YLH IIHRD+K N+F Sbjct: 112 VYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHDLN--IIHRDMKLGNLF 169 Query: 205 INGHDGQVKIGDFGLATFLH-QRKMRSIKGTLEFMAPELFT-GNYNELVDIYSFGMCMLE 378 +N D VKIGDFGLAT ++ + +++ GT ++APE+ ++ VDI++ G C+L Sbjct: 170 LN-DDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVG-CILY 227 Query: 379 MVTCEYPYSECQGKPWIYKKI 441 ++ P E + Y +I Sbjct: 228 ILLFGQPPFESKSLEETYSRI 248
>RK_HUMAN (Q15835) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 563 Score = 71.6 bits (174), Expect = 2e-12 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 8/128 (6%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFL--HQRKMRSIK 288 + QI+ GLE+LH + I++RDLK +N+ ++ +DG V+I D GLA L Q K + Sbjct: 297 YTAQIICGLEHLHQRR--IVYRDLKPENVLLD-NDGNVRISDLGLAVELLDGQSKTKGYA 353 Query: 289 GTLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPY----SECQGKPWIYKKISQGI 453 GT FMAPEL G Y+ VD ++ G+ + EM+ P+ + + K ++ IS+ + Sbjct: 354 GTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPV 413 Query: 454 K-PDVLSK 474 K PD S+ Sbjct: 414 KYPDKFSQ 421
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 71.6 bits (174), Expect = 2e-12 Identities = 50/142 (35%), Positives = 82/142 (57%), Gaps = 2/142 (1%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 +I + G L + + K + +A +I++ LEYLHS + I++RDLK +N+ IN Sbjct: 349 MIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQ--IVYRDLKPENLLIN 406 Query: 211 GHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELF-TGNYNELVDIYSFGMCMLEMVT 387 DG +KI DFG A L R ++ GT E++APE+ + +N+ VD ++ G+ + EM+ Sbjct: 407 -RDGHLKITDFGFAKKLRDRTW-TLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLV 464 Query: 388 CEYPYSECQGKPW-IYKKISQG 450 P+ + Q P+ IY+KI G Sbjct: 465 GYPPFYDEQ--PFGIYEKILSG 484
>RIPK5_BRARE (Q4VSN1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 885 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/171 (30%), Positives = 83/171 (48%), Gaps = 23/171 (13%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 720 ALDVVEGIRFLHSQ--GLLHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 773 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + +C K ++ + +G +P Sbjct: 774 TPIHMAPELFTGKYDNSVDVYAFGILFWYLCSGSVKLPEAFEKCASKDQLWTNVKKGCRP 833 Query: 460 DVLSKVEDAEVRGFIEIC-----------------LAPVTERLCASELLKN 561 + L V D E +E C L + ERLC + L++ Sbjct: 834 ERL-PVFDEECWQLMEACWNGDPSQRPLLGIVQPGLQSIMERLCGEKSLED 883
>M4K1_MOUSE (P70218) Mitogen-activated protein kinase kinase kinase kinase 1| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK) Length = 827 Score = 71.6 bits (174), Expect = 2e-12 Identities = 51/170 (30%), Positives = 83/170 (48%), Gaps = 8/170 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I E C +GSL+ + + + ++L GL YLHS++ IHRD+K NI IN Sbjct: 89 ICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSEKK--IHRDIKGANILIN 146 Query: 211 GHDGQVKIGDFGLATFLHQRKMRSIK--GTLEFMAPEL----FTGNYNELVDIYSFGMCM 372 G+VK+ DFG++ + R + GT +MAPE+ G YNEL DI+S G+ Sbjct: 147 DC-GEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITA 205 Query: 373 LEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVE--DAEVRGFIEICL 516 +E+ + P + ++ G +P L + + F+++ L Sbjct: 206 IELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTL 255
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 71.6 bits (174), Expect = 2e-12 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 8/195 (4%) Frame = +1 Query: 22 TVNIITELC---TSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKC 192 T ++ E C S L +K +V + A+ A+Q GL YLHS +IHRD+K Sbjct: 100 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHN--MIHRDVKA 154 Query: 193 DNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFT----GNYNELVDIYSF 360 NI ++ G VK+GDFG A+ + S GT +MAPE+ G Y+ VD++S Sbjct: 155 GNILLS-EPGLVKLGDFGSASIM--APANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 211 Query: 361 GMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTERLC 540 G+ +E+ + P +Y I+Q P + S R F++ CL + + Sbjct: 212 GITCIELAERKPPLFNMNAMSALY-HIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRP 270 Query: 541 ASE-LLKNCFLQKDK 582 SE LLK+ F+ +++ Sbjct: 271 TSEVLLKHRFVLRER 285
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 71.6 bits (174), Expect = 2e-12 Identities = 54/157 (34%), Positives = 85/157 (54%), Gaps = 8/157 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQ--RKMRSIKGTL 297 + L GL++LHS+ +IHRD+K DNI +N DG +KI DFG +++ K ++ GT Sbjct: 1056 ETLKGLKFLHSK--GVIHRDIKSDNILLN-MDGNIKITDFGFCAQINEINSKRITMVGTP 1112 Query: 298 EFMAPELFT-GNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ + Y VD++S G+ ++EM+ E PY +Y + G P+ Sbjct: 1113 YWMAPEIVSRKEYGPKVDVWSLGIMIIEMLEGEPPYLNETPLRALYLIATNGTPKLKDPE 1172 Query: 463 VLSKVEDAEVRGFIEICL-APVTERLCASELLKNCFL 570 LS ++R F+ CL +R A ELL + F+ Sbjct: 1173 SLS----YDIRKFLAWCLQVDFNKRADADELLHDNFI 1205
>MP2K1_PANTR (Q9XT09) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 71.2 bits (173), Expect = 3e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q KK ++ + + +I ++ GL YL + I+HRD++ NI Sbjct: 138 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVQPSNIL 196 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE F G +Y+ DI+S G+ +EM Sbjct: 197 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERFQGTHYSVQSDIWSMGLSPVEM 255 Query: 382 VTCEYP 399 YP Sbjct: 256 AVGRYP 261
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 71.2 bits (173), Expect = 3e-12 Identities = 61/191 (31%), Positives = 93/191 (48%), Gaps = 7/191 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQ-ILAGLEYLHSQEPAIIHRDLKCDNIFI 207 I+ E C +GS+ + NK + +Q L GLEYLH IHRD+K NI + Sbjct: 100 IVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK--IHRDIKAGNILL 157 Query: 208 NGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLE 378 N +G K+ DFG+A L K ++ GT +MAPE+ YN + DI+S G+ +E Sbjct: 158 NT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIE 216 Query: 379 MVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVE--DAEVRGFIEICLAPVTE-RLCASE 549 M + PY++ I+ + P K E F++ CL E R A++ Sbjct: 217 MAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQ 274 Query: 550 LLKNCFLQKDK 582 LL++ F++ K Sbjct: 275 LLQHPFVRSAK 285
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 71.2 bits (173), Expect = 3e-12 Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q K+ ++ + + +I +L GL YL + I+HRD+K NI Sbjct: 143 ISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ-IMHRDVKPSNIL 201 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +MAPE G +Y+ DI+S G+ ++E+ Sbjct: 202 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVEL 260 Query: 382 VTCEYP 399 YP Sbjct: 261 AVGRYP 266
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 71.2 bits (173), Expect = 3e-12 Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDG--QVKIGDFGLATFLHQR-KMRSIKGT 294 QIL+G+ YLH I+HRD+K +NI + + +KI DFGL++F + K+R GT Sbjct: 172 QILSGICYLHKHN--IVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGT 229 Query: 295 LEFMAPELFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG 450 ++APE+ YNE D++S G+ M ++ C YP Q I KK+ +G Sbjct: 230 AYYIAPEVLKKKYNEKCDVWSCGVIMY-ILLCGYPPFGGQNDQDIIKKVEKG 280
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 71.2 bits (173), Expect = 3e-12 Identities = 53/153 (34%), Positives = 84/153 (54%), Gaps = 8/153 (5%) Frame = +1 Query: 136 GLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMR--SIKGTLEFMA 309 GL++LH+++ IIHRD+K DNI +N G VKI DFG L +++ + ++ GT +MA Sbjct: 494 GLKFLHNKK--IIHRDIKSDNILLNSQ-GLVKITDFGFCVELTEKRSKRATMVGTPYWMA 550 Query: 310 PELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPDVLSK 474 PE+ Y+E VD++S G+ ++EM+ E PY +Y + G P+ +SK Sbjct: 551 PEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSK 610 Query: 475 VEDAEVRGFIEICL-APVTERLCASELLKNCFL 570 + + F++ CL V R +LL FL Sbjct: 611 ----QTKQFLDACLQVNVESRASVRKLLTFEFL 639
>PMYT1_MOUSE (Q9ESG9) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 490 Score = 71.2 bits (173), Expect = 3e-12 Identities = 49/150 (32%), Positives = 79/150 (52%), Gaps = 2/150 (1%) Frame = +1 Query: 112 GWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKM-RSIK 288 G+ IL L++LHSQ ++H D+K NIF+ G G+ K+GDFGL L + + Sbjct: 203 GYLRDILLALDHLHSQ--GLVHLDVKPANIFL-GPRGRCKLGDFGLLVELGSTGAGEAQE 259 Query: 289 GTLEFMAPELFTGNYNELVDIYSFGMCMLEMV-TCEYPYSECQGKPWIYKKISQGIKPDV 465 G +MAPEL G+Y D++S G+ +LE+ E P+ G+ W +++ QG P Sbjct: 260 GDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHG---GEGW--QQLRQGYLPPE 314 Query: 466 LSKVEDAEVRGFIEICLAPVTERLCASELL 555 + +E+R + + L P + +E L Sbjct: 315 FTAGLSSELRSVLAMMLEPDPQLRATAEAL 344
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 71.2 bits (173), Expect = 3e-12 Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDG--QVKIGDFGLATFLHQ-RKMRSIKGT 294 QIL+G+ YLH I+HRD+K +NI + +KI DFGL++F + K+R GT Sbjct: 173 QILSGICYLHKHN--IVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGT 230 Query: 295 LEFMAPELFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG 450 ++APE+ YNE D++S G+ +L ++ C YP Q I KK+ +G Sbjct: 231 AYYIAPEVLRKKYNEKCDVWSCGV-ILYILLCGYPPFGGQNDQDIIKKVEKG 281
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 71.2 bits (173), Expect = 3e-12 Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDG--QVKIGDFGLATFLHQ-RKMRSIKGT 294 QIL+G+ YLH I+HRD+K +NI + +KI DFGL++F + K+R GT Sbjct: 173 QILSGICYLHKHN--IVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGT 230 Query: 295 LEFMAPELFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG 450 ++APE+ YNE D++S G+ +L ++ C YP Q I KK+ +G Sbjct: 231 AYYIAPEVLRKKYNEKCDVWSCGV-ILYILLCGYPPFGGQNDQDIIKKVEKG 281
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 71.2 bits (173), Expect = 3e-12 Identities = 60/191 (31%), Positives = 95/191 (49%), Gaps = 7/191 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQ-ILAGLEYLHSQEPAIIHRDLKCDNIFI 207 I+ E C +GS+ + NK ++ ++ L GLEYLH IHRD+K NI + Sbjct: 97 IVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK--IHRDIKAGNILL 154 Query: 208 NGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLE 378 N +G K+ DFG+A L K ++ GT +MAPE+ YN + DI+S G+ +E Sbjct: 155 NT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIE 213 Query: 379 MVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVE--DAEVRGFIEICLAPVTE-RLCASE 549 M + PY++ I+ + P K E + F++ CL E R A++ Sbjct: 214 MAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQ 271 Query: 550 LLKNCFLQKDK 582 LL++ F++ K Sbjct: 272 LLQHPFIKNAK 282
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 71.2 bits (173), Expect = 3e-12 Identities = 47/143 (32%), Positives = 77/143 (53%), Gaps = 3/143 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E + G L + +H + R +A I + L YLH+ I+HRDLK +NI I+ Sbjct: 221 MLFEYVSGGQLLDYIIQHGSIREHQARKFARGIASALIYLHANN--IVHRDLKIENIMIS 278 Query: 211 GHDGQVKIGDFGLATFLHQRK-MRSIKGTLEFMAPELFTGN--YNELVDIYSFGMCMLEM 381 ++KI DFGL+ RK + + G+L F APEL N VD++SFG+ + + Sbjct: 279 -DSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVL 337 Query: 382 VTCEYPYSECQGKPWIYKKISQG 450 V + P+ + + +++KI QG Sbjct: 338 VCGKVPFDD-ENSSVLHEKIKQG 359
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 70.9 bits (172), Expect = 3e-12 Identities = 46/143 (32%), Positives = 81/143 (56%), Gaps = 3/143 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E + G L + +H + R +A I + L+YLH+ I+HRDLK +NI I+ Sbjct: 200 MLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANN--IVHRDLKIENIMIS 257 Query: 211 GHDGQVKIGDFGLAT-FLHQRKMRSIKGTLEFMAPELFTGN--YNELVDIYSFGMCMLEM 381 G++KI DFGL+ F +++++ + G+L F APEL VDI+SFG+ + + Sbjct: 258 S-SGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVL 316 Query: 382 VTCEYPYSECQGKPWIYKKISQG 450 V + P+ + + +++KI +G Sbjct: 317 VCGKVPFDD-ENSSILHEKIKKG 338
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) Length = 497 Score = 70.9 bits (172), Expect = 3e-12 Identities = 60/191 (31%), Positives = 94/191 (49%), Gaps = 7/191 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQ-ILAGLEYLHSQEPAIIHRDLKCDNIFI 207 I+ E C +GS+ + NK + ++ L GLEYLH IHRD+K NI + Sbjct: 97 IVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRK--IHRDIKAGNILL 154 Query: 208 NGHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLE 378 N +G K+ DFG+A L K ++ GT +MAPE+ YN + DI+S G+ +E Sbjct: 155 NT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIE 213 Query: 379 MVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVE--DAEVRGFIEICLAPVTE-RLCASE 549 M + PY++ I+ + P K E + F++ CL E R A++ Sbjct: 214 MAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQ 271 Query: 550 LLKNCFLQKDK 582 LL++ F++ K Sbjct: 272 LLQHPFIKNAK 282
>KR1_CHV9D (Q04543) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 345 Score = 70.9 bits (172), Expect = 3e-12 Identities = 44/101 (43%), Positives = 57/101 (56%), Gaps = 4/101 (3%) Frame = +1 Query: 127 ILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATF---LHQRKMRSIKGTL 297 +L ++YLH E IIHRD+K +NIFIN H G V +GDFG A + + Q K GT+ Sbjct: 146 VLRAIQYLH--ENRIIHRDVKAENIFIN-HPGDVCLGDFGAACYPVDITQNKYYGWAGTI 202 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQG 417 APEL + Y VDI+S G+ + EM TC E G Sbjct: 203 ATNAPELLARDPYGPAVDIWSAGIVLFEMATCHDSLFEKDG 243
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 70.9 bits (172), Expect = 3e-12 Identities = 55/199 (27%), Positives = 100/199 (50%), Gaps = 5/199 (2%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G V ++ E +G L + K + + Q+ L+Y+H + I+HR Sbjct: 174 GYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHERN--ILHR 231 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ-RKMRSIKGTLEFMAPELFTGN-YNELVDIY 354 D+K +NI I G + +K+ DFG + + K +++ GT+++++PEL YNE VD++ Sbjct: 232 DIKPENIII-GFNNTIKLTDFGWSVITPKGSKRKTLCGTVDYLSPELIRSREYNEKVDVW 290 Query: 355 SFGMCMLEMVTCEYPYSECQGKPWIYKKISQG--IKPDVLSKVEDAEVRGFIEICLA-PV 525 + G+ E++ P+ E + K YK+I + I PD + D E R I L Sbjct: 291 ALGVLTYELLVGSPPFEE-ESKELTYKRILKRNLIFPDHV----DTEARHLISRLLEYDP 345 Query: 526 TERLCASELLKNCFLQKDK 582 +R+ E+ K+ +++K+K Sbjct: 346 GDRIPLKEVKKHPWIEKNK 364
>RK_RAT (Q63651) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 70.5 bits (171), Expect = 4e-12 Identities = 43/116 (37%), Positives = 69/116 (59%), Gaps = 3/116 (2%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIK 288 + QI++GLE+LH + I++RDLK +N+ ++ +DG ++I D GLA L Q K + Sbjct: 297 YTAQIISGLEHLHQRR--IVYRDLKPENVLLD-NDGNIRISDLGLAVELKEGQNKTKGYA 353 Query: 289 GTLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI 453 GT FMAPEL G Y+ VD ++ G+ + EM+ P+ +G+ K++ Q I Sbjct: 354 GTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPF-RARGEKVENKELKQRI 408
>RK_MOUSE (Q9WVL4) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 70.5 bits (171), Expect = 4e-12 Identities = 43/116 (37%), Positives = 69/116 (59%), Gaps = 3/116 (2%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIK 288 + QI++GLE+LH + I++RDLK +N+ ++ +DG ++I D GLA L Q K + Sbjct: 297 YTAQIISGLEHLHQRR--IVYRDLKPENVLLD-NDGNIRISDLGLAVELKEGQNKTKGYA 353 Query: 289 GTLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI 453 GT FMAPEL G Y+ VD ++ G+ + EM+ P+ +G+ K++ Q I Sbjct: 354 GTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPF-RARGEKVENKELKQRI 408
>MP2K3_MOUSE (O09110) Dual specificity mitogen-activated protein kinase kinase 3| (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) Length = 347 Score = 70.5 bits (171), Expect = 4e-12 Identities = 56/181 (30%), Positives = 93/181 (51%), Gaps = 8/181 (4%) Frame = +1 Query: 64 RQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDF 243 R+ +K+ K+ + A+ I+ LE+LHS+ ++IHRD+K N+ IN +G VK+ DF Sbjct: 152 RKVLEKNMKIPEDILGEIAVSIVRALEHLHSKL-SVIHRDVKPSNVLIN-KEGHVKMCDF 209 Query: 244 GLATFLHQRKMRSIK-GTLEFMAPE-----LFTGNYNELVDIYSFGMCMLEMVTCEYPYS 405 G++ +L +++ G +MAPE L YN D++S G+ M+EM +PY Sbjct: 210 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY- 268 Query: 406 ECQGKPW-IYKKISQGIKPDVLSKVEDAEVRGFIEICLAP-VTERLCASELLKNCFLQKD 579 E G P+ K++ + P + + E F CL ER+ EL+++ F Sbjct: 269 ESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLH 328 Query: 580 K 582 K Sbjct: 329 K 329
>ARBK1_MESAU (Q64682) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 70.5 bits (171), Expect = 4e-12 Identities = 42/139 (30%), Positives = 73/139 (52%), Gaps = 2/139 (1%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 RT ++ I +L G L +H MR +A +I+ GLE++H++ +++RDLK Sbjct: 262 RTPDNLSFILDLMNGGDLHYHLSQHGVFSEADMRSYAAEIILGLEHMHNR--FVVYRDLK 319 Query: 190 CDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN--YNELVDIYSFG 363 NI ++ H G V+I D GLA ++K + GT +MAPE+ Y+ D +S G Sbjct: 320 PANILLDEH-GHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG 378 Query: 364 MCMLEMVTCEYPYSECQGK 420 + +++ P+ + + K Sbjct: 379 CMLFKLLRGHSPFRQHKTK 397
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 70.5 bits (171), Expect = 4e-12 Identities = 42/105 (40%), Positives = 61/105 (58%), Gaps = 9/105 (8%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEPA-IIHRDLKCDNIF----INGHDGQ---VKIGDFGLATFLHQR 270 WA+QI G+ YLH + +IHRDLK +NI I D + +KI DFGLA H+ Sbjct: 218 WAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKT 277 Query: 271 KMRSIKGTLEFMAPELF-TGNYNELVDIYSFGMCMLEMVTCEYPY 402 S GT +MAPE+ +++ D++SFG+ + E++T E PY Sbjct: 278 TQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPY 322
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 70.5 bits (171), Expect = 4e-12 Identities = 50/157 (31%), Positives = 90/157 (57%), Gaps = 8/157 (5%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMR--SIKGTL 297 + L+GLE+LHS+ ++HRD+K DNI ++ +G +K+ DFG +++ ++ ++ GT Sbjct: 722 ETLSGLEFLHSK--GVLHRDIKSDNILLS-MEGDIKLTDFGFCAQINELNLKRTTMVGTP 778 Query: 298 EFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI----KPD 462 +MAPE+ + Y VDI+S G+ ++EM+ E PY +Y + G +P+ Sbjct: 779 YWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPE 838 Query: 463 VLSKVEDAEVRGFIEICLAPVTE-RLCASELLKNCFL 570 LS + ++ F++ CL E R A+ELL + ++ Sbjct: 839 NLS----SSLKKFLDWCLCVEPEDRASATELLHDEYI 871
>MP2K5_RAT (Q62862) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 448 Score = 70.5 bits (171), Expect = 4e-12 Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 1/131 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I TE GSL +RK V + A+ ++ GL YL S + I+HRD+K N+ Sbjct: 237 ISICTEFMDGGSLDVYRKIPEHV----LGRIAVAVVKGLTYLWSLK--ILHRDVKPSNML 290 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N GQVK+ DFG++T L ++ GT +MAPE +G Y D++S G+ +E+ Sbjct: 291 VNT-SGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEL 349 Query: 382 VTCEYPYSECQ 414 +PY + Q Sbjct: 350 ALGRFPYPQIQ 360
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 70.1 bits (170), Expect = 6e-12 Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 3/132 (2%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + + I+ E C+ S+ K + +R + QI++GL+YLH QE I+HRDLK Sbjct: 149 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLG 206 Query: 196 NIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPELFT-GNYNELVDIYSFGM 366 N FIN ++K+GDFGLA L + + R+I GT +++PE+ + DI++ G Sbjct: 207 NFFIN-EAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGC 265 Query: 367 CMLEMVTCEYPY 402 M M+ P+ Sbjct: 266 VMYTMLLGRPPF 277
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 70.1 bits (170), Expect = 6e-12 Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 3/132 (2%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + + I+ E C+ S+ K + +R + QI++GL+YLH QE I+HRDLK Sbjct: 149 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLG 206 Query: 196 NIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPELFT-GNYNELVDIYSFGM 366 N FIN ++K+GDFGLA L + + R+I GT +++PE+ + DI++ G Sbjct: 207 NFFIN-EAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGC 265 Query: 367 CMLEMVTCEYPY 402 M M+ P+ Sbjct: 266 VMYTMLLGRPPF 277
>KPCD_HUMAN (Q05655) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 676 Score = 70.1 bits (170), Expect = 6e-12 Identities = 41/134 (30%), Positives = 73/134 (54%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T+ + + E G L + + + +A +I+ GL++LHS+ II+RDLK Sbjct: 418 QTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSK--GIIYRDLK 475 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSF 360 DN+ ++ DG +KI DFG+ + + + GT +++APE+ G Y VD +SF Sbjct: 476 LDNVLLD-RDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSF 534 Query: 361 GMCMLEMVTCEYPY 402 G+ + EM+ + P+ Sbjct: 535 GVLLYEMLIGQSPF 548
>RIPK5_CANFA (Q4VSN4) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 931 Score = 70.1 bits (170), Expect = 6e-12 Identities = 52/166 (31%), Positives = 79/166 (47%), Gaps = 23/166 (13%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 760 ALDVVEGIRFLHSQ--GLVHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 813 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + C K ++ + +G +P Sbjct: 814 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARP 873 Query: 460 DVLSKVEDAEVRGFIEIC-----------------LAPVTERLCAS 546 + L V D E +E C L + ERLC S Sbjct: 874 ERL-PVFDEECWQLMEACWDGDPSQRPLLGIVQPMLQGIMERLCKS 918
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 70.1 bits (170), Expect = 6e-12 Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 3/132 (2%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + + I+ E C+ S+ K + +R + QI++GL+YLH QE I+HRDLK Sbjct: 152 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLG 209 Query: 196 NIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPELFT-GNYNELVDIYSFGM 366 N FIN ++K+GDFGLA L + + R+I GT +++PE+ + DI++ G Sbjct: 210 NFFIN-EAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGC 268 Query: 367 CMLEMVTCEYPY 402 M M+ P+ Sbjct: 269 VMYTMLLGRPPF 280
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 70.1 bits (170), Expect = 6e-12 Identities = 57/196 (29%), Positives = 91/196 (46%), Gaps = 11/196 (5%) Frame = +1 Query: 22 TVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNI 201 TV+I E GS+ + + + QIL G+ YLH E ++HRD+K +N+ Sbjct: 1135 TVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLH--ENCVVHRDIKGNNV 1192 Query: 202 FINGHDGQVKIGDFGLATFL--------HQRKMRSIKGTLEFMAPELFT-GNYNELVDIY 354 + G +K+ DFG A L H ++S+ GT +MAPE+ Y DI+ Sbjct: 1193 MLM-PTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIW 1251 Query: 355 SFGMCMLEMVTCEYPYSEC-QGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLA-PVT 528 S G + EM T + P + + Y +G+ P + + F+ +CL Sbjct: 1252 SIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSE-NAADFVRMCLTRDQH 1310 Query: 529 ERLCASELLKNCFLQK 576 ER A +LLK+ FL++ Sbjct: 1311 ERPSALQLLKHSFLER 1326
>RK_BOVIN (P28327) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 561 Score = 70.1 bits (170), Expect = 6e-12 Identities = 49/154 (31%), Positives = 82/154 (53%), Gaps = 7/154 (4%) Frame = +1 Query: 13 TRXTVNIITELCTSGSLRQ--FRKKHNKVGMKAMRG--WAIQILAGLEYLHSQEPAIIHR 180 T+ + ++ + G +R + + G + R + QI++GLE+LH + II+R Sbjct: 256 TKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRN--IIYR 313 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPELFTG-NYNELVDI 351 DLK +N+ ++ DG V+I D GLA L Q K + GT FMAPEL G Y+ VD Sbjct: 314 DLKPENVLLDD-DGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDY 372 Query: 352 YSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI 453 ++ G+ + EM+ P+ +G+ K++ Q + Sbjct: 373 FALGVTLYEMIAARGPF-RARGEKVENKELKQRV 405
>MP2K5_MOUSE (Q9WVS7) Dual specificity mitogen-activated protein kinase kinase 5| (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 448 Score = 70.1 bits (170), Expect = 6e-12 Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 1/131 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I TE GSL +RK V + A+ ++ GL YL S + I+HRD+K N+ Sbjct: 237 ISICTEFMDGGSLDVYRKIPEHV----LGRIAVAVVKGLTYLWSLK--ILHRDVKPSNML 290 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N GQVK+ DFG++T L ++ GT +MAPE +G Y D++S G+ +E+ Sbjct: 291 VNT-GGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEL 349 Query: 382 VTCEYPYSECQ 414 +PY + Q Sbjct: 350 ALGRFPYPQIQ 360
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 70.1 bits (170), Expect = 6e-12 Identities = 50/134 (37%), Positives = 73/134 (54%), Gaps = 8/134 (5%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAI--QILAGLEYLHSQEPAIIHRDLKCDNIF 204 + E C G L F + VGM Q++AG+EYLHS I HRD+K +N+ Sbjct: 82 LFLEYCRGGEL--FDRIEPDVGMPEQDAQKFFQQLIAGVEYLHS--IGITHRDIKPENLL 137 Query: 205 INGHDGQVKIGDFGLAT-FLHQRKMRSIK---GTLEFMAPELFTGN--YNELVDIYSFGM 366 ++ D Q+KI DFGLAT F H K R + GTL ++APEL + + VD++S G+ Sbjct: 138 LDERD-QLKISDFGLATVFRHNGKERLLNKMCGTLPYVAPELIKSRAFHADPVDVWSCGI 196 Query: 367 CMLEMVTCEYPYSE 408 + M+ E P+ + Sbjct: 197 VLTAMLAGELPWDQ 210
>RIPK5_HUMAN (Q6XUX3) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) Length = 929 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 758 ALDVVEGIRFLHSQ--GLVHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 811 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + C K ++ + +G +P Sbjct: 812 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARP 871 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L V D E +E C Sbjct: 872 ERL-PVFDEECWQLMEAC 888
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/126 (34%), Positives = 70/126 (55%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E SL KK ++ K + ++ ++ GL YL E I+HRD+K N+ Sbjct: 144 ISICMEYMDGLSLDIVLKKVGRLPEKFVGRISVAVVRGLTYL-KDEIKILHRDVKPSNML 202 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N + G++K+ DFG++ L S GT +MAPE TG +Y DI+SFG+ ++E+ Sbjct: 203 VNSN-GEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVEL 261 Query: 382 VTCEYP 399 + YP Sbjct: 262 LIGRYP 267
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/171 (29%), Positives = 83/171 (48%), Gaps = 17/171 (9%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAI------QILAGLEYLHSQE 162 G+ + I+TE +GSL + H K + W + +I G+ YLH+ Sbjct: 83 GICNEPEFLGIVTEYMPNGSLNELL--HRKTEYPDI-AWPLRFRILHEIALGVNYLHNMN 139 Query: 163 PAIIHRDLKCDNIFINGHDGQVKIGDFGLATF--LHQRKMRSIK-----GTLEFMAPELF 321 P ++H DLK NI ++ ++ VKI DFGL+ + + + RS K GT+ +M PE + Sbjct: 140 PPLLHHDLKTQNILLD-NEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENY 198 Query: 322 TGNYNELV----DIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPD 462 DIYS+ + M E+++ + P+ E I +SQG +PD Sbjct: 199 EPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPD 249
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/110 (39%), Positives = 62/110 (56%), Gaps = 9/110 (8%) Frame = +1 Query: 115 WAIQILAGLEYLHSQEPA-IIHRDLKCDNIFI-----NGHDGQ--VKIGDFGLATFLHQR 270 WA+QI G+ YLH + IIHRDLK NI I NG +KI DFGLA H+ Sbjct: 245 WAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRT 304 Query: 271 KMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQG 417 S GT +MAPE+ + +++ D++S+G+ + E++T E P+ G Sbjct: 305 TKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDG 354
>RIPK5_PANTR (Q4VSN5) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 759 ALDVVEGIRFLHSQ--GLVHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 812 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + C K ++ + +G +P Sbjct: 813 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARP 872 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L V D E +E C Sbjct: 873 ERL-PVFDEECWQLMEAC 889
>PAK6_HUMAN (Q9NQU5) Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1)| (p21-activated kinase 6) (PAK-6) (PAK-5) Length = 681 Score = 69.7 bits (169), Expect = 7e-12 Identities = 54/153 (35%), Positives = 84/153 (54%), Gaps = 5/153 (3%) Frame = +1 Query: 127 ILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQR--KMRSIKGTLE 300 +L L YLH+Q +IHRD+K D+I + DG+VK+ DFG + + K +S+ GT Sbjct: 510 VLQALAYLHAQ--GVIHRDIKSDSILLT-LDGRVKLSDFGFCAQISKDVPKRKSLVGTPY 566 Query: 301 FMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV 477 +MAPE+ + + Y VDI+S G+ ++EMV E PY K++ P + + Sbjct: 567 WMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSH 625 Query: 478 EDAEV-RGFIE-ICLAPVTERLCASELLKNCFL 570 + + V R F+E + + ER A ELL + FL Sbjct: 626 KVSPVLRDFLERMLVRDPQERATAQELLDHPFL 658
>KPCD_CANFA (Q5PU49) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 674 Score = 69.7 bits (169), Expect = 7e-12 Identities = 40/134 (29%), Positives = 75/134 (55%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T+ + + E G L + + + +A +I+ GL++LH++ II+RDLK Sbjct: 416 QTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIVCGLQFLHNK--GIIYRDLK 473 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSF 360 DN+ ++ DG +KI DFG+ +++ + GT +++APE+ G Y+ VD +SF Sbjct: 474 LDNVMLD-QDGHIKIADFGMCKENIFGEKQASTFCGTPDYIAPEILQGLKYSFSVDWWSF 532 Query: 361 GMCMLEMVTCEYPY 402 G+ + EM+ + P+ Sbjct: 533 GVLLYEMLIGQSPF 546
>IKKB_DROME (Q9VEZ5) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.1) (DmIKK-beta) (Immune response deficient protein 5) (IKK-like protein) (Lipopolysaccharide-activated kinase) (DLAK) (Cactus kinase IKK) Length = 751 Score = 69.3 bits (168), Expect = 1e-11 Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 8/132 (6%) Frame = +1 Query: 31 IITELCTSGSLRQ-FRKKHNKVGMKAMRGWAI--QILAGLEYLHSQEPAIIHRDLKCDNI 201 I+ E C G +R+ + N G+ I + L +LHSQ I HRDLK DNI Sbjct: 132 IVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQ-CGICHRDLKPDNI 190 Query: 202 FIN-GHDGQ--VKIGDFGLATFLHQRKM-RSIKGTLEFMAPELF-TGNYNELVDIYSFGM 366 I G DG+ K+ DFGLA + M +S+ GT + APE+ G YN VD++SFG+ Sbjct: 191 VIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVENGFYNSTVDLWSFGV 250 Query: 367 CMLEMVTCEYPY 402 E+VT E P+ Sbjct: 251 IAYELVTGELPF 262
>KPCD_MOUSE (P28867) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 674 Score = 69.3 bits (168), Expect = 1e-11 Identities = 41/134 (30%), Positives = 74/134 (55%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T+ + + E G L + + + +A +I+ GL++LHS+ II+RDLK Sbjct: 416 QTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSK--GIIYRDLK 473 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSF 360 DN+ ++ DG +KI DFG+ + + + GT +++APE+ G Y+ VD +SF Sbjct: 474 LDNVMLD-RDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSF 532 Query: 361 GMCMLEMVTCEYPY 402 G+ + EM+ + P+ Sbjct: 533 GVLLYEMLIGQSPF 546
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 69.3 bits (168), Expect = 1e-11 Identities = 57/209 (27%), Positives = 100/209 (47%), Gaps = 16/209 (7%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAG-LEYLHSQEPAIIHR 180 + T + ++ ELC G L++ + R W IQ LA + YLH+ + I+HR Sbjct: 181 VFETPKKMYLVMELCEDGELKEILDRKGHFSENETR-WIIQSLASAIAYLHNND--IVHR 237 Query: 181 DLKCDNIFI--------NGHDGQVKIGDFGLATFLHQRK---MRSIKGTLEFMAPELFTG 327 DLK +NI + N + +K+ DFGLA R +++ GT +MAPE+ + Sbjct: 238 DLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISA 297 Query: 328 -NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQG---IKPDVLSKVEDAEVR 495 +Y++ DI+S G+ M ++ E P+ + +++ I +G + V + + D Sbjct: 298 HDYSQQCDIWSIGVVMYMLLRGEPPFL-ASSEEKLFELIRKGELHFENAVWNSISDCAKS 356 Query: 496 GFIEICLAPVTERLCASELLKNCFLQKDK 582 ++ R+ A ELL N +L +K Sbjct: 357 VLKQLMKVDPAHRITAKELLDNQWLTGNK 385
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 69.3 bits (168), Expect = 1e-11 Identities = 41/142 (28%), Positives = 76/142 (53%), Gaps = 1/142 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + +I E G L + ++H K+ + ++ L Y H E +IHRD+K +N+ Sbjct: 89 IYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCH--EKKVIHRDIKPENLL 146 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEM 381 + G +G+VKI DFG + + +++ GTL+++ PE+ YNE+VD++ G+ E+ Sbjct: 147 L-GLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYEL 205 Query: 382 VTCEYPYSECQGKPWIYKKISQ 447 + + P+ E Y++I Q Sbjct: 206 LVGKPPF-ESSTSSETYRRIRQ 226
>RIPK5_BOVIN (Q4TVR5) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 928 Score = 69.3 bits (168), Expect = 1e-11 Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 757 ALDVVEGIRFLHSQ--GLVHRDVKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 810 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + C K ++ + +G +P Sbjct: 811 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARP 870 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L V D E +E C Sbjct: 871 ERL-PVFDEECWQLMEAC 887
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 69.3 bits (168), Expect = 1e-11 Identities = 57/188 (30%), Positives = 96/188 (51%), Gaps = 6/188 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E G+L H+++ + + Q L L YLHSQ +IHRD+K D+I + Sbjct: 440 VVMEYLEGGALTDI-VTHSRMDEEQIATVCKQCLKALAYLHSQ--GVIHRDIKSDSILLA 496 Query: 211 GHDGQVKIGDFGLATFLHQR--KMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 DG+VK+ DFG + Q K +S+ GT +M+PE+ + Y VDI+S G+ ++EM Sbjct: 497 A-DGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEM 555 Query: 382 VTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVR--GFIE-ICLAPVTERLCASEL 552 V E P+ P + + ++P L R F++ + + +R A+EL Sbjct: 556 VDGEPPF--FNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAEL 613 Query: 553 LKNCFLQK 576 L + FL++ Sbjct: 614 LAHPFLRQ 621
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 69.3 bits (168), Expect = 1e-11 Identities = 59/204 (28%), Positives = 93/204 (45%), Gaps = 24/204 (11%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 R VNI E C GSL + + ++L GL YLH + ++HRD+K + Sbjct: 1105 RDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLH--QSGVVHRDIKPE 1162 Query: 196 NIFINGHDGQVKIGDFGLATFLHQRKMRSIK------------------GTLEFMAPELF 321 NI ++ +G +K DFG A + + R+++ GT +MAPE Sbjct: 1163 NILLD-FNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETI 1221 Query: 322 TGNYNE----LVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVE-DA 486 +G+ + D+++ G +LEM T P+S + I ++ G P + ++ E A Sbjct: 1222 SGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTA 1281 Query: 487 EVRGFIEICLA-PVTERLCASELL 555 R F+E CL T R A ELL Sbjct: 1282 AGRAFLERCLVQDPTMRATAVELL 1305
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/123 (34%), Positives = 67/123 (54%), Gaps = 9/123 (7%) Frame = +1 Query: 76 KKHNKVGMKAMRGWAIQILAGLEYLHSQE-PAIIHRDLKCDNIFING---HDG----QVK 231 ++ ++ + WA+QI G+ YLH + I+HRDLK NI + HD +K Sbjct: 227 RRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLK 286 Query: 232 IGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLEMVTCEYPYSE 408 I DFGLA H+ S GT +MAPE+ + +++ DI+S+G+ + E++T E PY Sbjct: 287 ITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRG 346 Query: 409 CQG 417 G Sbjct: 347 IDG 349
>RIPK5_RAT (Q6XUX2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 69.3 bits (168), Expect = 1e-11 Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 756 ALDVVEGIRFLHSQ--GLVHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 809 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + + + C K ++ + +G +P Sbjct: 810 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRP 869 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L V D E +E C Sbjct: 870 ERL-PVFDEECWQLMEAC 886
>RIPK5_MOUSE (Q6XUX1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 69.3 bits (168), Expect = 1e-11 Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LHSQ ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 756 ALDVVEGIRFLHSQ--GLVHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 809 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + + + C K ++ + +G +P Sbjct: 810 TPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRP 869 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L V D E +E C Sbjct: 870 ERL-PVFDEECWQLMEAC 886
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 69.3 bits (168), Expect = 1e-11 Identities = 49/146 (33%), Positives = 78/146 (53%), Gaps = 10/146 (6%) Frame = +1 Query: 34 ITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFING 213 + EL +G L Q+ KK+ + +R +A +IL+ +EY+HS IIHRDLK +NI +G Sbjct: 131 VLELAPNGELLQYIKKYRFLDENCVRFYAAEILSSIEYMHS--CGIIHRDLKPENILFDG 188 Query: 214 HDGQVKIGDFGLATFLHQRKMR---------SIKGTLEFMAPELFTGN-YNELVDIYSFG 363 + VKI DFG A L + + S GT E++APEL + ++ D+++F Sbjct: 189 -NMHVKITDFGTAKILPPKYVNSPDYTTFPSSFVGTAEYVAPELLSRQVVSKSSDLWAFA 247 Query: 364 MCMLEMVTCEYPYSECQGKPWIYKKI 441 + +M+ P+ I+KKI Sbjct: 248 CVVYQMIVGSPPFHGSNPNN-IFKKI 272
>NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC 2.7.11.1) (N-rich| kinase 1) Length = 652 Score = 68.9 bits (167), Expect = 1e-11 Identities = 59/187 (31%), Positives = 96/187 (51%), Gaps = 5/187 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 II + C GS+R + + + + L L+++H IIHRD+K NI ++ Sbjct: 86 IIMDYCHGGSVRTLMEA-GPISEPCISLILRETLQALKFIH--HAGIIHRDIKAANILVS 142 Query: 211 GHDGQVKIGDFGLATFLH--QRKMRSIKGTLEFMAPELFTGN--YNELVDIYSFGMCMLE 378 G VK+ DFG+A L+ +RK + GT +MAPE+ YN + DI+S G+ E Sbjct: 143 -MSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYE 201 Query: 379 MVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAPVTE-RLCASELL 555 + T P++ + P+ + P L+ A ++ FI CL V + RL +SELL Sbjct: 202 IATGSPPHA--KEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASCLQDVPQRRLDSSELL 259 Query: 556 KNCFLQK 576 K+ F+++ Sbjct: 260 KSKFIKQ 266
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/126 (33%), Positives = 69/126 (54%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q K+ ++ + + +I +L GL YL + I+HRD+K NI Sbjct: 141 ISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ-IMHRDVKPSNIL 199 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++E+ Sbjct: 200 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEL 258 Query: 382 VTCEYP 399 YP Sbjct: 259 SIGRYP 264
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/126 (33%), Positives = 68/126 (53%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q K+ ++ + +I +L GL YL + I+HRD+K NI Sbjct: 143 ISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQ-IMHRDVKPSNIL 201 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++E+ Sbjct: 202 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEL 260 Query: 382 VTCEYP 399 YP Sbjct: 261 AIGRYP 266
>E2AK3_CAEEL (Q19192) Eukaryotic translation initiation factor 2-alpha kinase| precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (CePEK) Length = 1077 Score = 68.9 bits (167), Expect = 1e-11 Identities = 62/203 (30%), Positives = 97/203 (47%), Gaps = 22/203 (10%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMK---AMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNI 201 I+ +LC +L + ++ + + M+ W Q+ +GLEYLH++ IHRDLK N+ Sbjct: 882 IVMQLCAEKTLEDWIRRSKTMESRPLFTMKNWIKQLASGLEYLHNK--GFIHRDLKPGNV 939 Query: 202 FI---NGHDGQV-KIGDFGLAT--------FLHQRKMRSIK-----GTLEFMAPE-LFTG 327 F + H Q+ KIGD GLAT + Q S K GT +M+PE L Sbjct: 940 FFSLDSTHGHQILKIGDLGLATKTDGAPKITVRQDSDSSAKHTKNVGTRSYMSPEQLKHQ 999 Query: 328 NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGF-I 504 Y E VDI++ G+ E++ +S + + +G P +L V E R F + Sbjct: 1000 QYTEKVDIFALGLVATELI---ISFSTASERIHTFADFQKGDIPAILDNV--PESRDFLL 1054 Query: 505 EICLAPVTERLCASELLKNCFLQ 573 ++ +ER A E+ + FLQ Sbjct: 1055 QLTSLEPSERPTAHEVATHKFLQ 1077
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/126 (33%), Positives = 68/126 (53%), Gaps = 1/126 (0%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 ++I E GSL Q K+ ++ + +I +L GL YL + I+HRD+K NI Sbjct: 143 ISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQ-IMHRDVKPSNIL 201 Query: 205 INGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSFGMCMLEM 381 +N G++K+ DFG++ L S GT +M+PE G +Y+ DI+S G+ ++E+ Sbjct: 202 VNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEL 260 Query: 382 VTCEYP 399 YP Sbjct: 261 AIGRYP 266
>KR1_EHV1V (P84390) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 382 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/102 (46%), Positives = 60/102 (58%), Gaps = 2/102 (1%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLE 300 QIL GL YLH+Q IIHRD+K +NIFIN D QV I DFG A F + + + GT+E Sbjct: 190 QILEGLRYLHAQR--IIHRDVKTENIFINSVD-QVCIADFGAAQFPVVEPADLGLAGTVE 246 Query: 301 FMAPE-LFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKP 423 APE L YN DI+S G+ + EM+ YP + + P Sbjct: 247 TNAPEVLARAKYNSKADIWSAGIVLFEMLA--YPSTLFEDPP 286
>KR1_EHV1K (P32516) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 382 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/102 (46%), Positives = 60/102 (58%), Gaps = 2/102 (1%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLE 300 QIL GL YLH+Q IIHRD+K +NIFIN D QV I DFG A F + + + GT+E Sbjct: 190 QILEGLRYLHAQR--IIHRDVKTENIFINSVD-QVCIADFGAAQFPVVEPADLGLAGTVE 246 Query: 301 FMAPE-LFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKP 423 APE L YN DI+S G+ + EM+ YP + + P Sbjct: 247 TNAPEVLARAKYNSKADIWSAGIVLFEMLA--YPSTLFEDPP 286
>KR1_EHV1B (P28926) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 382 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/102 (46%), Positives = 60/102 (58%), Gaps = 2/102 (1%) Frame = +1 Query: 124 QILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATF-LHQRKMRSIKGTLE 300 QIL GL YLH+Q IIHRD+K +NIFIN D QV I DFG A F + + + GT+E Sbjct: 190 QILEGLRYLHAQR--IIHRDVKTENIFINSVD-QVCIADFGAAQFPVVEPADLGLAGTVE 246 Query: 301 FMAPE-LFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKP 423 APE L YN DI+S G+ + EM+ YP + + P Sbjct: 247 TNAPEVLARAKYNSKADIWSAGIVLFEMLA--YPSTLFEDPP 286
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 68.6 bits (166), Expect = 2e-11 Identities = 54/164 (32%), Positives = 82/164 (50%), Gaps = 18/164 (10%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGW------AIQILAGLEYLHSQE-PAIIHRDLK 189 ++ E +GSL + + N+ GM + W A+ GL +LH P IIHRD+K Sbjct: 988 LVYEYMVNGSLDHWLR--NQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIK 1045 Query: 190 CDNIFINGHDGQVKIGDFGLATFL---HQRKMRSIKGTLEFMAPEL-FTGNYNELVDIYS 357 NI ++G D + K+ DFGLA + I GT ++ PE + D+YS Sbjct: 1046 ASNILLDG-DFEPKVADFGLARLISACESHVSTVIAGTFGYIPPEYGQSARATTKGDVYS 1104 Query: 358 FGMCMLEMVTCEYP----YSECQG---KPWIYKKISQGIKPDVL 468 FG+ +LE+VT + P + E +G W +KI+QG DV+ Sbjct: 1105 FGVILLELVTGKEPTGPDFKESEGGNLVGWAIQKINQGKAVDVI 1148
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 68.6 bits (166), Expect = 2e-11 Identities = 40/137 (29%), Positives = 72/137 (52%), Gaps = 14/137 (10%) Frame = +1 Query: 34 ITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFING 213 + E +G KK+ + R +A QI+ ++YLHS IIHRD+K +NI ++G Sbjct: 256 LLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSN--GIIHRDIKPENILLDG 313 Query: 214 HDGQVKIGDFGLATFLH-------------QRKMRSIKGTLEFMAPELFTGNYNEL-VDI 351 + ++K+ DFG A L+ + +S GT E+++PEL ++ + DI Sbjct: 314 -EMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDI 372 Query: 352 YSFGMCMLEMVTCEYPY 402 ++FG + +M+ + P+ Sbjct: 373 WAFGCILFQMIAGKPPF 389
>ARBK2_BOVIN (P26818) Beta-adrenergic receptor kinase 2 (EC 2.7.11.15)| (Beta-ARK-2) (G-protein-coupled receptor kinase 3) Length = 688 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/131 (31%), Positives = 70/131 (53%), Gaps = 2/131 (1%) Frame = +1 Query: 34 ITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFING 213 I +L G L +H K MR +A +I+ GLE++H++ +++RDLK NI ++ Sbjct: 270 ILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNR--FVVYRDLKPANILLDE 327 Query: 214 HDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN--YNELVDIYSFGMCMLEMVT 387 H G V+I D GLA ++K + GT +MAPE+ Y+ D +S G + +++ Sbjct: 328 H-GHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLR 386 Query: 388 CEYPYSECQGK 420 P+ + + K Sbjct: 387 GHSPFRQHKTK 397
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 68.6 bits (166), Expect = 2e-11 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 7/176 (3%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + N+ E GS+ K+ + + Q+L GL YLH + IIHRD+K Sbjct: 1297 KSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQ--IIHRDVKGA 1354 Query: 196 NIFINGHDGQVKIGDFGLATFLHQRK------MRSIKGTLEFMAPELFTG-NYNELVDIY 354 N+ I+ +++I DFG A L + + GT+ FMAPE+ G Y D++ Sbjct: 1355 NLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVW 1414 Query: 355 SFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP 522 S G ++EM C PW +K S + ++ K+ A I L+P Sbjct: 1415 SVGCAIIEMA--------CAKPPWNAEKHSNHLA--LIFKIASATTAPSIPSHLSP 1460
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 68.6 bits (166), Expect = 2e-11 Identities = 62/186 (33%), Positives = 91/186 (48%), Gaps = 17/186 (9%) Frame = +1 Query: 49 TSGSLRQFRKKHNKVGMKAMRG-----WAIQILAGLEYLHSQEPAIIHRDLKCDNIFING 213 T + RQ ++ G KA+ ++ I+ GL +LHSQ I+H DLK NI I Sbjct: 158 TRDAWRQGEEEEGGCGRKALSMAEAVCYSCDIVTGLAFLHSQ--GIVHLDLKPANILITE 215 Query: 214 HDGQVKIGDFGLATFLHQRKMRSIK-----GTLEFMAPELFTGN-YNELVDIYSFGMCML 375 H G KIGDFG + L + +S GT APEL G DIYSF + + Sbjct: 216 H-GACKIGDFGCSQRLEEGLSQSHHVCQQGGTYTHRAPELLKGERVTAKADIYSFAITLW 274 Query: 376 EMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKV--EDA---EVRGFIEIC-LAPVTERL 537 ++V E PY + + +Y ++ ++P + + + E A +R I C A V ERL Sbjct: 275 QIVMREQPYLG-ERQYVLYAVVAYNLRPPLAAAIFHESAVGQRLRSIISCCWKADVEERL 333 Query: 538 CASELL 555 A++LL Sbjct: 334 SAAQLL 339
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/149 (28%), Positives = 78/149 (52%), Gaps = 2/149 (1%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G V ++ E G L +F K + + + Q+ L+Y+HS+ I+HR Sbjct: 165 GFFYDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVYQMANALDYMHSKN--ILHR 222 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQ-RKMRSIKGTLEFMAPELFTGN-YNELVDIY 354 D+K +NI I G + +K+ DFG + + +K +++ GT+++++PEL YN VD++ Sbjct: 223 DIKPENILI-GFNNTIKLTDFGWSVYNEDGQKRKTLCGTIDYLSPELIKSREYNNKVDVW 281 Query: 355 SFGMCMLEMVTCEYPYSECQGKPWIYKKI 441 + G+ E++ P+ E K Y++I Sbjct: 282 ALGVLTYELLVGSPPFEE-DTKEMTYRRI 309
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 68.6 bits (166), Expect = 2e-11 Identities = 50/137 (36%), Positives = 80/137 (58%), Gaps = 4/137 (2%) Frame = +1 Query: 109 RGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLA-TFLHQRKMRSI 285 R + +I++ + +LH E I+HRDLK +NI ++ DG V + DFGLA F + S+ Sbjct: 235 RVYTAEIVSAVSHLH--EKGIMHRDLKPENILMD-TDGHVMLTDFGLAKEFEENTRSNSM 291 Query: 286 KGTLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKI-SQGIK- 456 GT E+MAPE+ G +++ D +S G+ + EM+T + P+ +GK I +KI IK Sbjct: 292 CGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSKGK--IQQKIVKDKIKL 349 Query: 457 PDVLSKVEDAEVRGFIE 507 P LS A ++G ++ Sbjct: 350 PQFLSNEAHAILKGLLQ 366
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 68.6 bits (166), Expect = 2e-11 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 7/176 (3%) Frame = +1 Query: 16 RXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCD 195 + N+ E GS+ K+ + + Q+L GL YLH + IIHRD+K Sbjct: 1299 KSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQ--IIHRDVKGA 1356 Query: 196 NIFINGHDGQVKIGDFGLATFLHQRK------MRSIKGTLEFMAPELFTG-NYNELVDIY 354 N+ I+ +++I DFG A L + + GT+ FMAPE+ G Y D++ Sbjct: 1357 NLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVW 1416 Query: 355 SFGMCMLEMVTCEYPYSECQGKPWIYKKISQGIKPDVLSKVEDAEVRGFIEICLAP 522 S G ++EM C PW +K S + ++ K+ A I L+P Sbjct: 1417 SVGCAIIEMA--------CAKPPWNAEKHSNHLA--LIFKIASATTAPSIPSHLSP 1462
>KPCD_RAT (P09215) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 673 Score = 68.2 bits (165), Expect = 2e-11 Identities = 40/134 (29%), Positives = 73/134 (54%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T+ + + E G L + + + +A +I+ GL++LH + II+RDLK Sbjct: 416 QTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHGK--GIIYRDLK 473 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG-NYNELVDIYSF 360 DN+ ++ DG +KI DFG+ + + + GT +++APE+ G Y+ VD +SF Sbjct: 474 LDNVMLD-KDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYSFSVDWWSF 532 Query: 361 GMCMLEMVTCEYPY 402 G+ + EM+ + P+ Sbjct: 533 GVLLYEMLIGQSPF 546
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 68.2 bits (165), Expect = 2e-11 Identities = 41/148 (27%), Positives = 73/148 (49%), Gaps = 1/148 (0%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHR 180 G + V +I E G L + + + + Q+ L YLH + IIHR Sbjct: 164 GHFHDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALLYLHGKN--IIHR 221 Query: 181 DLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIKGTLEFMAPELFTGN-YNELVDIYS 357 D+K +NI ++ +D +KI DFG + + ++ GT++++ PE+ Y++ VD++S Sbjct: 222 DIKPENILLHFND-TIKISDFGWSVHAPSNRRSTLCGTMDYLPPEIVQSRPYDKNVDVWS 280 Query: 358 FGMCMLEMVTCEYPYSECQGKPWIYKKI 441 G+ M E + P+ E G Y++I Sbjct: 281 LGILMYEFLCGAPPFEEPGGAQATYRRI 308
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 68.2 bits (165), Expect = 2e-11 Identities = 56/194 (28%), Positives = 96/194 (49%), Gaps = 8/194 (4%) Frame = +1 Query: 25 VNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 + ++ ELCT G L K QI + L YLH + I HRD+K +N Sbjct: 188 IYLVMELCTGGELFDKIVKKGCFVETFASFIMKQIFSVLNYLHIRN--ICHRDIKPENFL 245 Query: 205 INGH--DGQVKIGDFGLATFL--HQRKMRSIKGTLEFMAPELFTGNYNELVDIYSFGMCM 372 + +KI DFGLA++ + +M++ GT ++AP++ TG+YN D++S G+ + Sbjct: 246 FYDMTPESLIKIIDFGLASYFTHNNYEMKTKAGTPYYVAPQVLTGSYNYKCDMWSSGV-L 304 Query: 373 LEMVTCEYPYSECQGKPWIYKKISQG---IKPDVLSKVEDAEVRGFIEICLA-PVTERLC 540 ++ C YP + I + +G K + + + E + I+ CL +R+C Sbjct: 305 FYILLCGYPPFFGESDHEILSMVKKGKYQFKGKEWNNISE-EAKDLIKRCLTMDADKRIC 363 Query: 541 ASELLKNCFLQKDK 582 ASE L++ + +K K Sbjct: 364 ASEALQHPWFKKKK 377
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 68.2 bits (165), Expect = 2e-11 Identities = 46/144 (31%), Positives = 79/144 (54%), Gaps = 4/144 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKK--HNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 I E G+L +F +K ++ + + + + +QIL L ++H+ I+HRDLK NI Sbjct: 78 IAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTH--LILHRDLKTQNIL 135 Query: 205 INGHDGQVKIGDFGLATFLHQR-KMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLE 378 ++ H VKIGDFG++ L + K ++ GT +++PEL G YN+ DI++ G + E Sbjct: 136 LDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYE 195 Query: 379 MVTCEYPYSECQGKPWIYKKISQG 450 + + + + E P + KI G Sbjct: 196 LASLKRAF-EAANLPALVLKIMSG 218
>NEK1_HUMAN (Q96PY6) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) (NY-REN-55 antigen) Length = 1258 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/150 (30%), Positives = 79/150 (52%), Gaps = 7/150 (4%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGM----KAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDN 198 I+ + C G L F++ + + G+ + W +QI L+++H ++ I+HRD+K N Sbjct: 78 IVMDYCEGGDL--FKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK--ILHRDIKSQN 133 Query: 199 IFINGHDGQVKIGDFGLATFLHQ--RKMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMC 369 IF+ DG V++GDFG+A L+ R+ GT +++PE+ YN DI++ G Sbjct: 134 IFLT-KDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCV 192 Query: 370 MLEMVTCEYPYSECQGKPWIYKKISQGIKP 459 + E+ T ++ + K + K IS P Sbjct: 193 LYELCTLKHAFEAGSMKNLVLKIISGSFPP 222
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/193 (27%), Positives = 97/193 (50%), Gaps = 10/193 (5%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 I+ EL G L + ++ + + Q+L ++YLH E IIHRDLK +N+ ++ Sbjct: 299 IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH--ENGIIHRDLKPENVLLS 356 Query: 211 GH--DGQVKIGDFGLATFLHQRK-MRSIKGTLEFMAPELF----TGNYNELVDIYSFGMC 369 D +KI DFG + L + MR++ GT ++APE+ T YN VD +S G+ Sbjct: 357 SQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVI 416 Query: 370 MLEMVTCEYPYSECQGKPWIYKKISQG---IKPDVLSKVEDAEVRGFIEICLAPVTERLC 540 + ++ P+SE + + + +I+ G P+V ++V + + ++ + R Sbjct: 417 LFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFT 476 Query: 541 ASELLKNCFLQKD 579 E L++ +LQ + Sbjct: 477 TEEALRHPWLQDE 489
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 68.2 bits (165), Expect = 2e-11 Identities = 50/137 (36%), Positives = 80/137 (58%), Gaps = 4/137 (2%) Frame = +1 Query: 109 RGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLA-TFLHQRKMRSI 285 R + +I++ + +LH E I+HRDLK +NI ++ DG V + DFGLA F + S+ Sbjct: 241 RVYTAEIVSAVSHLH--EKGIMHRDLKPENILMD-VDGHVMLTDFGLAKEFEENTRSNSM 297 Query: 286 KGTLEFMAPELFTG-NYNELVDIYSFGMCMLEMVTCEYPYSECQGKPWIYKKI-SQGIK- 456 GT E+MAPE+ G +++ D +S G+ + EM+T + P+ +GK I +KI IK Sbjct: 298 CGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSKGK--IQQKIVKDKIKL 355 Query: 457 PDVLSKVEDAEVRGFIE 507 P LS A ++G ++ Sbjct: 356 PQFLSNEAHALLKGLLQ 372
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 68.2 bits (165), Expect = 2e-11 Identities = 40/136 (29%), Positives = 74/136 (54%), Gaps = 3/136 (2%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 ++ T T+ ++ E + G + + H ++ K R QI++ ++Y H + I+HRD Sbjct: 125 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY--IVHRD 182 Query: 184 LKCDNIFINGHDGQVKIGDFGLAT-FLHQRKMRSIKGTLEFMAPELFTGNYNE--LVDIY 354 LK +N+ ++G D +KI DFG + F K+ + G+ + APELF G + VD++ Sbjct: 183 LKAENLLLDG-DMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 Query: 355 SFGMCMLEMVTCEYPY 402 S G+ + +V+ P+ Sbjct: 242 SLGVILYTLVSGSLPF 257
>PMYT1_HUMAN (Q99640) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 499 Score = 68.2 bits (165), Expect = 2e-11 Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 2/150 (1%) Frame = +1 Query: 112 GWAIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIK- 288 G+ L L +LHSQ ++H D+K NIF+ G G+ K+GDFGL L ++ Sbjct: 212 GYLRDTLLALAHLHSQ--GLVHLDVKPANIFL-GPRGRCKLGDFGLLVELGTAGAGEVQE 268 Query: 289 GTLEFMAPELFTGNYNELVDIYSFGMCMLEMV-TCEYPYSECQGKPWIYKKISQGIKPDV 465 G +MAPEL G+Y D++S G+ +LE+ E P+ G+ W +++ QG P Sbjct: 269 GDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHG---GEGW--QQLRQGYLPPE 323 Query: 466 LSKVEDAEVRGFIEICLAPVTERLCASELL 555 + +E+R + + L P + +E L Sbjct: 324 FTAGLSSELRSVLVMMLEPDPKLRATAEAL 353
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 68.2 bits (165), Expect = 2e-11 Identities = 46/144 (31%), Positives = 79/144 (54%), Gaps = 4/144 (2%) Frame = +1 Query: 31 IITELCTSGSLRQFRKK--HNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIF 204 I E G+L +F +K ++ + + + + +QIL L ++H+ I+HRDLK NI Sbjct: 78 IAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTH--LILHRDLKTQNIL 135 Query: 205 INGHDGQVKIGDFGLATFLHQR-KMRSIKGTLEFMAPELFTGN-YNELVDIYSFGMCMLE 378 ++ H VKIGDFG++ L + K ++ GT +++PEL G YN+ DI++ G + E Sbjct: 136 LDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYE 195 Query: 379 MVTCEYPYSECQGKPWIYKKISQG 450 + + + + E P + KI G Sbjct: 196 LASLKRAF-EAANLPALVLKIMSG 218
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 67.8 bits (164), Expect = 3e-11 Identities = 44/153 (28%), Positives = 81/153 (52%), Gaps = 3/153 (1%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 ++ T + ++ E + G L + K+ ++ K R QIL+G++Y H ++HRD Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRH--MVVHRD 139 Query: 184 LKCDNIFINGHDGQVKIGDFGLATFLHQRK-MRSIKGTLEFMAPELFTGNY--NELVDIY 354 LK +N+ ++ H KI DFGL+ + + +R+ G+ + APE+ +G VDI+ Sbjct: 140 LKPENVLLDAH-MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 Query: 355 SFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI 453 S G+ + ++ P+ + P ++KKI GI Sbjct: 199 SSGVILYALLCGTLPFDD-DHVPTLFKKICDGI 230
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 67.8 bits (164), Expect = 3e-11 Identities = 44/153 (28%), Positives = 81/153 (52%), Gaps = 3/153 (1%) Frame = +1 Query: 4 LMRTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRD 183 ++ T + ++ E + G L + K+ ++ K R QIL+G++Y H ++HRD Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRH--MVVHRD 139 Query: 184 LKCDNIFINGHDGQVKIGDFGLATFLHQRK-MRSIKGTLEFMAPELFTGNY--NELVDIY 354 LK +N+ ++ H KI DFGL+ + + +R+ G+ + APE+ +G VDI+ Sbjct: 140 LKPENVLLDAH-MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 Query: 355 SFGMCMLEMVTCEYPYSECQGKPWIYKKISQGI 453 S G+ + ++ P+ + P ++KKI GI Sbjct: 199 SSGVILYALLCGTLPFDD-DHVPTLFKKICDGI 230
>KPC1_ASPNG (Q00078) Protein kinase C-like (EC 2.7.11.13)| Length = 1096 Score = 67.8 bits (164), Expect = 3e-11 Identities = 43/134 (32%), Positives = 70/134 (52%), Gaps = 3/134 (2%) Frame = +1 Query: 10 RTRXTVNIITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLK 189 +T V + E + G L + + G+K + +A ++L L+Y H E +I+RDLK Sbjct: 842 QTETRVYFVMEYISGGDL-MLHIQRGQFGLKRAQFYAAEVLLALKYFH--ENGVIYRDLK 898 Query: 190 CDNIFINGHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPE-LFTGNYNELVDIYSF 360 DNI + DG +K+ D+GL + + GT EFMAPE L Y VD ++F Sbjct: 899 LDNIMLT-LDGHIKVADYGLCKENMWYGATTSTFCGTPEFMAPEILLDKRYGRAVDWWAF 957 Query: 361 GMCMLEMVTCEYPY 402 G+ + +M+ + P+ Sbjct: 958 GVLIYQMLLQQSPF 971
>MP2K3_HUMAN (P46734) Dual specificity mitogen-activated protein kinase kinase 3| (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) Length = 347 Score = 67.8 bits (164), Expect = 3e-11 Identities = 53/163 (32%), Positives = 85/163 (52%), Gaps = 8/163 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRSIK-GT 294 A+ I+ LE+LHS+ ++IHRD+K N+ IN +G VK+ DFG++ +L +++ G Sbjct: 170 AVSIVRALEHLHSKL-SVIHRDVKPSNVLIN-KEGHVKMCDFGISGYLVDSVAKTMDAGC 227 Query: 295 LEFMAPE-----LFTGNYNELVDIYSFGMCMLEMVTCEYPYSECQGKPW-IYKKISQGIK 456 +MAPE L YN D++S G+ M+EM +PY E G P+ K++ + Sbjct: 228 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY-ESWGTPFQQLKQVVEEPS 286 Query: 457 PDVLSKVEDAEVRGFIEICLAP-VTERLCASELLKNCFLQKDK 582 P + + E F CL ER+ EL+++ F K Sbjct: 287 PQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 329
>RIPK5_FUGRU (Q4VSN2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 921 Score = 67.8 bits (164), Expect = 3e-11 Identities = 44/138 (31%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +1 Query: 118 AIQILAGLEYLHSQEPAIIHRDLKCDNIFINGHDGQVKIGDFGLATFLHQRKMRS--IKG 291 A+ ++ G+ +LH+Q ++HRD+K N+ ++ + + KI D G F M S I G Sbjct: 751 ALDVVEGIRFLHNQ--GLLHRDIKLKNVLLDKQN-RAKITDLG---FCKPEAMMSGSIVG 804 Query: 292 TLEFMAPELFTGNYNELVDIYSFGMCMLEM----VTCEYPYSECQGKPWIYKKISQGIKP 459 T MAPELFTG Y+ VD+Y+FG+ + V + +C K ++ + +G +P Sbjct: 805 TPIHMAPELFTGKYDNSVDVYAFGILFWYLCAGSVKLPEAFEKCSSKDQLWNNVKKGARP 864 Query: 460 DVLSKVEDAEVRGFIEIC 513 + L D E +E C Sbjct: 865 ERL-PCFDEECWQLMEAC 881
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 67.8 bits (164), Expect = 3e-11 Identities = 47/144 (32%), Positives = 75/144 (52%), Gaps = 8/144 (5%) Frame = +1 Query: 1 GLMRTRXTVNIITELCTSGSLRQFR--KKHNKVGMKAMRGWAIQILAGLEYLHSQ-EPAI 171 G + + T ++ E +GSL + K + + A++ GL YLH P I Sbjct: 754 GYVANKDTNLLLYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLI 813 Query: 172 IHRDLKCDNIFINGHDGQVKIGDFGLATFL----HQRKMRSIKGTLEFMAPEL-FTGNYN 336 +HRD+K +NI ++ D + + DFGLA FL M SI G+ ++APE +T + Sbjct: 814 LHRDVKSNNILLDS-DFEAHVADFGLAKFLVDGAASECMSSIAGSYGYIAPEYAYTLKVD 872 Query: 337 ELVDIYSFGMCMLEMVTCEYPYSE 408 E D+YSFG+ +LE++ + P E Sbjct: 873 EKSDVYSFGVVLLELIAGKKPVGE 896
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 67.8 bits (164), Expect = 3e-11 Identities = 45/125 (36%), Positives = 67/125 (53%), Gaps = 4/125 (3%) Frame = +1 Query: 31 IITELCTSGSLRQFRKKHNKVGMKAMRGWAIQILAGLEYLHSQEPAIIHRDLKCDNIFIN 210 ++ E C L QF + +K+ + R QIL GL + H + I+HRD+K NI IN Sbjct: 78 LVFEFCDE-DLYQFMSRSSKIPINETRSIVYQILQGLAFCHYHQ--ILHRDMKPQNILIN 134 Query: 211 GHDGQVKIGDFGLA--TFLHQRKMRSIKGTLEFMAPELFTG--NYNELVDIYSFGMCMLE 378 +G +K+G+FGLA T ++ RK S TL + APE+ G Y +DI+S E Sbjct: 135 -KNGTIKLGEFGLARLTTINDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGE 193 Query: 379 MVTCE 393 ++ E Sbjct: 194 LINKE 198 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 97,178,719 Number of Sequences: 219361 Number of extensions: 2047843 Number of successful extensions: 7887 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6366 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6607 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6427774254 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
