>MTHR_ORYSA (Q75HE6) Probable methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 594

 Score =  410 bits (1055), Expect = e-114
 Identities = 192/208 (92%), Positives = 203/208 (97%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGITCPIVPGIMPINNYKGF+RMTGFCKTKIPAEITAAL+PIKDNEEAVKAYGIHLGTEM
Sbjct: 211 IGITCPIVPGIMPINNYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEM 270

Query: 183 CKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPI 362
           CKKILA+GIKTLHLYTLNMEK+AL ILMNLGLIEESK+SR+LPWRPPTNVFRVKEDVRPI
Sbjct: 271 CKKILATGIKTLHLYTLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPI 330

Query: 363 FWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKS 542
           FWANRPKSYISRT GWDQYP GRWGDSRNPSYGAL D+QFTRPRGRGKKLQEEWAVP+KS
Sbjct: 331 FWANRPKSYISRTLGWDQYPHGRWGDSRNPSYGALTDYQFTRPRGRGKKLQEEWAVPVKS 390

Query: 543 VQDINERFVNFCEGKLKSSPWSELDGLQ 626
           V+DINERF+NFC+GKL SSPWSELDGLQ
Sbjct: 391 VEDINERFMNFCQGKLTSSPWSELDGLQ 418

>MTHR1_MAIZE (Q9SE94) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
           (ZmMTHFR1)
          Length = 593

 Score =  400 bits (1029), Expect = e-111
 Identities = 186/208 (89%), Positives = 198/208 (95%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGITCPIVPGIMPINNYKGF+RMTGFCKTKIP+EITAALDPIKDNEEAV+ YGIHLGTEM
Sbjct: 211 IGITCPIVPGIMPINNYKGFLRMTGFCKTKIPSEITAALDPIKDNEEAVRQYGIHLGTEM 270

Query: 183 CKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPI 362
           CKKILA+GIKTLHLYTLNM+K+A+ ILMNLGLIEESK+SR LPWRP TNVFRVKEDVRPI
Sbjct: 271 CKKILATGIKTLHLYTLNMDKSAIGILMNLGLIEESKVSRPLPWRPATNVFRVKEDVRPI 330

Query: 363 FWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKS 542
           FWANRPKSY+ RT GWDQYP GRWGDSRNPSYGAL DHQFTRPRGRGKKLQEEWAVPLKS
Sbjct: 331 FWANRPKSYLKRTLGWDQYPHGRWGDSRNPSYGALTDHQFTRPRGRGKKLQEEWAVPLKS 390

Query: 543 VQDINERFVNFCEGKLKSSPWSELDGLQ 626
           V+DI+ERF NFC+GKL SSPWSELDGLQ
Sbjct: 391 VEDISERFTNFCQGKLTSSPWSELDGLQ 418

>MTHR2_ARATH (O80585) Methylenetetrahydrofolate reductase 2 (EC 1.5.1.20)|
           (AtMTHFR2)
          Length = 594

 Score =  368 bits (945), Expect = e-102
 Identities = 169/208 (81%), Positives = 190/208 (91%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGI+CPIVPGIMPINNY+GF+RMTGFCKTKIP E+ AAL+PIKDNEEAVKAYGIHLGTEM
Sbjct: 211 IGISCPIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEM 270

Query: 183 CKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPI 362
           CKK+LA G+K+LHLYTLNMEK+ALAILMNLG+I+ESK+SR+LPWR P NVFR KEDVRPI
Sbjct: 271 CKKMLAHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPI 330

Query: 363 FWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKS 542
           FWANRPKSYISRT GW+ +PQGRWGDSR+ SYGAL+DHQF+RPR R KKLQ+EW VPLKS
Sbjct: 331 FWANRPKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKS 390

Query: 543 VQDINERFVNFCEGKLKSSPWSELDGLQ 626
           V+DI E+F   C G LKSSPWSELDGLQ
Sbjct: 391 VEDIQEKFKELCLGNLKSSPWSELDGLQ 418

>MTHR1_ARATH (Q9SE60) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
           (AtMTHFR1)
          Length = 592

 Score =  347 bits (890), Expect = 2e-95
 Identities = 157/208 (75%), Positives = 182/208 (87%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGI CPIVPGIMPI+NYKGF+RM GFCKTKIPAE+TAAL+PIKDN+EAVKAYGIH  TEM
Sbjct: 211 IGINCPIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEM 270

Query: 183 CKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPI 362
           CKKILA GI +LHLYTLN++K+A+ ILMNLGLI+ESK+SR+LPWR P NVFR KEDVRPI
Sbjct: 271 CKKILAHGITSLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPI 330

Query: 363 FWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKS 542
           FWANRPKSYISRT GW+ +P GRWGDS + +Y  L+D+QF RP+GR KKLQ+EW VPLKS
Sbjct: 331 FWANRPKSYISRTKGWNDFPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKS 390

Query: 543 VQDINERFVNFCEGKLKSSPWSELDGLQ 626
           ++D+ E+F   C G LKSSPWSELDGLQ
Sbjct: 391 IEDVQEKFKELCIGNLKSSPWSELDGLQ 418

>MTHR_HUMAN (P42898) Methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 656

 Score =  174 bits (440), Expect = 3e-43
 Identities = 88/213 (41%), Positives = 127/213 (59%), Gaps = 10/213 (4%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           +GITCPIVPGI PI  Y    ++    K ++P EI   ++PIKDN+ A++ YGI L   +
Sbjct: 246 MGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSL 305

Query: 183 CKKILASG-IKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRP 359
           C+++LASG +  LH YTLN E     +L  LG+  E    R LPW    +  R +EDVRP
Sbjct: 306 CQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRP 364

Query: 360 IFWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVP 533
           IFWA+RPKSYI RT  WD++P GRWG+S +P++G L D+   + + +   ++L + W   
Sbjct: 365 IFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEE 424

Query: 534 LKSVQDINERFVNFCEG-------KLKSSPWSE 611
           L S + + E FV +  G       K+   PW++
Sbjct: 425 LTSEESVFEVFVLYLSGEPNRNGHKVTCLPWND 457

>MTHR_MACFA (Q60HE5) Methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 656

 Score =  171 bits (432), Expect = 2e-42
 Identities = 88/213 (41%), Positives = 125/213 (58%), Gaps = 10/213 (4%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           +GITCPIVPGI PI  Y    ++    K ++P EI   ++PIKDN+ A++ YGI L   +
Sbjct: 246 MGITCPIVPGIFPIQGYHSLRQLVKQSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSL 305

Query: 183 CKKILASG-IKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRP 359
           C ++LASG +  LH YTLN E     +L  LG+  E    R LPW    +  R +EDVRP
Sbjct: 306 CHELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRP 364

Query: 360 IFWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVP 533
           IFWA+RPKSYI RT  WD++P GRWG+S +P++G L D+   + + +   + L + W   
Sbjct: 365 IFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPRELLLKMWGEE 424

Query: 534 LKSVQDINERFVNFCEG-------KLKSSPWSE 611
           L S + + E FV +  G       K+   PW++
Sbjct: 425 LTSEESVFEVFVLYLSGEPNRNGHKVTCLPWND 457

>MTHR_MOUSE (Q9WU20) Methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 654

 Score =  168 bits (425), Expect = 1e-41
 Identities = 83/213 (38%), Positives = 127/213 (59%), Gaps = 10/213 (4%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGI+CPI+PGI PI  Y    ++    K ++P +I   ++PIKDN+ A++ YGI L   +
Sbjct: 245 IGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVRL 304

Query: 183 CKKILASG-IKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRP 359
           C+++L SG +  LH YTLN E   + +L  LG+  E    R LPW    +  R +EDVRP
Sbjct: 305 CRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRP 363

Query: 360 IFWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVP 533
           IFWA+RPKSYI RT  WD++P GRWG+S +P++G L D+   + + +   ++L + W   
Sbjct: 364 IFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEE 423

Query: 534 LKSVQDINERFVNFCEG-------KLKSSPWSE 611
           L S + + E F ++  G       ++   PW++
Sbjct: 424 LTSEESVFEVFEHYLSGEPNRHGYRVTCLPWND 456

>MTHR1_SCHPO (Q10258) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
          Length = 603

 Score =  168 bits (425), Expect = 1e-41
 Identities = 88/212 (41%), Positives = 122/212 (57%), Gaps = 9/212 (4%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           GI  PI PGIMPI  +  F+R   +   KIP      L P+KD++E V+  G+ L  EMC
Sbjct: 203 GINIPIFPGIMPIQAWDSFIRRAKWSGVKIPQHFMDTLVPVKDDDEGVRERGVELIVEMC 262

Query: 186 KKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNV---------FR 338
           +K++ASGI  LH YT+N+EK    I+  LGL++E+      P     NV          R
Sbjct: 263 RKLIASGITRLHFYTMNLEKAVKMIIERLGLLDEN----LAPIVDTNNVELTNASSQDRR 318

Query: 339 VKEDVRPIFWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQE 518
           + E VRPIFW  R +SY+SRT  WD+ P GRWGDSR+P++G  +  ++   R   K++  
Sbjct: 319 INEGVRPIFWRTRNESYVSRTDQWDELPHGRWGDSRSPAFGEFDAIRYGL-RMSPKEITT 377

Query: 519 EWAVPLKSVQDINERFVNFCEGKLKSSPWSEL 614
            W  P KS  +I + F  +CE K+ S PWS+L
Sbjct: 378 SWGSP-KSYSEIGDLFARYCEKKISSLPWSDL 408

>MTHR2_YEAST (P53128) Methylenetetrahydrofolate reductase 2 (EC 1.5.1.20)|
          Length = 599

 Score =  164 bits (416), Expect = 2e-40
 Identities = 88/211 (41%), Positives = 127/211 (60%), Gaps = 8/211 (3%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           G+  PI+PGIMPI  Y  F+R   + +  IP   ++ LDPIKD++E V+  G +L  EMC
Sbjct: 207 GMDVPIIPGIMPITTYAAFLRRIQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMC 266

Query: 186 KKILASG-IKTLHLYTLNMEKTALAILMNLGLI-EESKLS----RTLPWRPPTNVFRVKE 347
           +K+L SG +  LH+YT+N+EK  L IL  L ++  ES+ +      LPWR   N  R  E
Sbjct: 267 QKLLDSGYVSHLHIYTMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNE 326

Query: 348 DVRPIFWANRPKSYISRTTGW--DQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEE 521
           +VRPIFW  RP SY++RT+ W  D++P GR+GDS +P++G L+       R    K  E 
Sbjct: 327 EVRPIFWKRRPYSYVARTSQWAVDEFPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLEL 386

Query: 522 WAVPLKSVQDINERFVNFCEGKLKSSPWSEL 614
           W+ P  S+ D+    +N+  G LK  PWS++
Sbjct: 387 WSTP-TSINDVAFLVINYLNGNLKCLPWSDI 416

>MTHR_CAEEL (Q17693) Probable methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 663

 Score =  144 bits (364), Expect = 2e-34
 Identities = 81/217 (37%), Positives = 128/217 (58%), Gaps = 12/217 (5%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGIT PI+PGIMPI  Y+   R+    + +IP  I   L+PIK +++AV+ YG     EM
Sbjct: 259 IGITQPIIPGIMPIMGYESIKRIAKLSQLEIPQHILDDLEPIKHDDDAVQKYGTERCIEM 318

Query: 183 CKKILASGIK-TLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPT-NVFRVKEDVR 356
           C+++L +G   ++HLYT+N E +   IL +LGL +     R  PW+  + +  R  E VR
Sbjct: 319 CRRLLDNGTAPSIHLYTMNREGSIREILKSLGLWKLEG-DRVFPWKNRSQHPIRCLESVR 377

Query: 357 PIFWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDH---QFTRPRGRGKKLQEEWA 527
           PI+W+ RP+SYI+RT  WDQ+P GRWG+S +P++G ++ +     T  R    +L   + 
Sbjct: 378 PIYWSFRPRSYITRTRDWDQFPNGRWGNSSSPAFGDVSSYYLSNLTTVRNADDRL-AMFG 436

Query: 528 VPLKSVQDINERFVNF------CEG-KLKSSPWSELD 617
             ++S +D+   F+N+       +G K+   PW+E +
Sbjct: 437 ANIESFEDVKRVFINYITQAPNADGVKVTVLPWTEAE 473

>MTHR2_SCHPO (O74927) Methylenetetrahydrofolate reductase 2 (EC 1.5.1.20)|
          Length = 641

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 65/246 (26%), Positives = 100/246 (40%), Gaps = 50/246 (20%)
 Frame = +3

Query: 18  PIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKIL 197
           PI+P IMPI +Y    RMT  C   +P+ +   L+  K ++EA+K  G+    +M KKI+
Sbjct: 217 PIIPAIMPIQSYGSLKRMTRLCGCSVPSSLMQRLNAAKPDDEAIKNIGVEHIVDMIKKIM 276

Query: 198 ---ASGIKTLHLYTLNMEKTALAILMNLGLI-----------EESKLSRT---------- 305
                 +   H  TLN+E++   IL N GL+           E+ KL RT          
Sbjct: 277 DNVQGRVHGFHFCTLNLERSVALILKNSGLLTKRWKQVESEMEDEKLLRTTRKRLSLDEP 336

Query: 306 --------LPWRPP-----TNVFRVKED-----------VRPIFWANRPKSYISRTTGWD 413
                   +P + P     +N+F   +                F  +     + R   WD
Sbjct: 337 AELHNQVVVPSQQPVADKSSNLFVTSKQSSVSGHKDNLTEEAPFSVSEGSGVLGRQANWD 396

Query: 414 QYPQGRWGDSRNPSYGALNDHQFTR--PRGRGKKLQEEWAVPLKSVQDINERFVNFCEGK 587
            +  GR+GD R+P+YG ++ +  T   P     KL   W  P+    DI   F       
Sbjct: 397 DFTNGRFGDPRSPAYGEIDGYGPTLHFPPSEALKL---WGYPVDE-SDITSLFQKHIMSD 452

Query: 588 LKSSPW 605
           + + PW
Sbjct: 453 ISAIPW 458

>METF_STRLI (O54235) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 307

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 33/91 (36%), Positives = 47/91 (51%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           G   P++P +MP+ + K   R+        PAE+   +   KD+  AV++ GI   TE C
Sbjct: 211 GCATPVIPEVMPVTSVKMLERLPKLSNASFPAELKERILTAKDDPAAVRSIGIEFATEFC 270

Query: 186 KKILASGIKTLHLYTLNMEKTALAILMNLGL 278
            ++LA G+  LH  TLN     L I  NLGL
Sbjct: 271 ARLLAEGVPGLHFITLNNSTATLEIYENLGL 301

>METF_AQUAE (O67422) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 296

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 31/85 (36%), Positives = 41/85 (48%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           GI   I+PGIMPI N+K   +    C   IP  +   L+ ++D  E VK  GI      C
Sbjct: 199 GIDISIIPGIMPITNFKQIRKFASLCGATIPQSLIEKLEKVEDKPEEVKKIGIEFAINQC 258

Query: 186 KKILASGIKTLHLYTLNMEKTALAI 260
             ++  G+  LH YTLN     L I
Sbjct: 259 LDLIEHGVPGLHFYTLNKSDATLKI 283

>METF_SHIFL (P0AEZ2) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 296

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 30/91 (32%), Positives = 48/91 (52%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           GI   I+PGI+P++N+K   +       +IPA +    D + D+ E  K  G ++  +M 
Sbjct: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261

Query: 186 KKILASGIKTLHLYTLNMEKTALAILMNLGL 278
           K +   G+K  H YTLN  + + AI   LG+
Sbjct: 262 KILSREGVKDFHFYTLNRAEMSYAICHTLGV 292

>METF_ECOLI (P0AEZ1) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 296

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 30/91 (32%), Positives = 48/91 (52%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           GI   I+PGI+P++N+K   +       +IPA +    D + D+ E  K  G ++  +M 
Sbjct: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261

Query: 186 KKILASGIKTLHLYTLNMEKTALAILMNLGL 278
           K +   G+K  H YTLN  + + AI   LG+
Sbjct: 262 KILSREGVKDFHFYTLNRAEMSYAICHTLGV 292

>MTHR1_YEAST (P46151) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
          Length = 657

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 27/75 (36%), Positives = 47/75 (62%)
 Frame = +3

Query: 390 ISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFV 569
           + R   WD++P GR+GDSR+P+YG ++ +  +    + K L E W +P K++ D+ + F+
Sbjct: 402 LGRDATWDEFPNGRFGDSRSPAYGEIDGYGPSIKVSKSKAL-ELWGIP-KTIGDLKDIFI 459

Query: 570 NFCEGKLKSSPWSEL 614
            + EG   + PWS+L
Sbjct: 460 KYLEGSTDAIPWSDL 474



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 31/86 (36%), Positives = 47/86 (54%), Gaps = 4/86 (4%)
 Frame = +3

Query: 18  PIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDP-IKDNEEAVKAYGIHLGTEMCKKI 194
           P+ PG+MPIN+Y  F R        IP  I +   P I+ ++ AVK+ G+ +  E+ ++I
Sbjct: 213 PLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQSDDNAVKSIGVDILIELIQEI 272

Query: 195 ---LASGIKTLHLYTLNMEKTALAIL 263
               +  IK  H YTLN+EK    I+
Sbjct: 273 YQRTSGRIKGFHFYTLNLEKAIAQIV 298

>METF_HAEIN (P45208) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 292

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 31/92 (33%), Positives = 45/92 (48%)
 Frame = +3

Query: 3   IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEM 182
           IGI   IVPGI+P+ N+K   +M  F   KIPA +  A D + ++          +  +M
Sbjct: 199 IGIDTEIVPGILPVTNFKQLQKMASFTNVKIPAWLVKAYDGLDNDPTTRNLVAASVAMDM 258

Query: 183 CKKILASGIKTLHLYTLNMEKTALAILMNLGL 278
            K +   G+   H YTLN  +   AI   LG+
Sbjct: 259 VKILSREGVNDFHFYTLNRSELTYAICHMLGV 290

>METF_PECCC (P71319) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 298

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 29/91 (31%), Positives = 47/91 (51%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           GI   IVPGI+P++N+K   +       ++P  +T   D + ++ E  K  G  +  +M 
Sbjct: 202 GIDVEIVPGILPVSNFKQLQKFATMTNVRVPNWMTTMFDGLDNDPETRKMVGASIAMDMV 261

Query: 186 KKILASGIKTLHLYTLNMEKTALAILMNLGL 278
           K +   G+K  H YTLN  + + AI   LG+
Sbjct: 262 KILSREGVKDFHFYTLNRAELSYAICHTLGV 292

>METF_SALTY (P11003) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 296

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 27/91 (29%), Positives = 49/91 (53%)
 Frame = +3

Query: 6   GITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMC 185
           GI   I+PGI+P++N+K   +       +IP+ ++   + + ++ E  K  G ++  +M 
Sbjct: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPSWMSLMFEGLDNDAETRKLVGANIAMDMV 261

Query: 186 KKILASGIKTLHLYTLNMEKTALAILMNLGL 278
           K +   G+K  H YTLN  + + AI   LG+
Sbjct: 262 KILSREGVKDFHFYTLNRAEMSYAICHTLGV 292

>METF_BUCAI (P57154) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 292

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 28/90 (31%), Positives = 43/90 (47%)
 Frame = +3

Query: 9   ITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCK 188
           I   I+PGI+P+ N++   R +     KIP  +    + + D+    K  G  +  +M K
Sbjct: 203 INIDIIPGILPVCNFQKLKRFSSMTNVKIPKWMLDMFNGLDDDIFTQKIIGSSIAIDMVK 262

Query: 189 KILASGIKTLHLYTLNMEKTALAILMNLGL 278
           K+   G+K  H YTLN      +I   LGL
Sbjct: 263 KLSCEGVKNFHFYTLNQSDITYSICHILGL 292

>METF_BUCBP (Q89B13) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 295

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 25/84 (29%), Positives = 43/84 (51%)
 Frame = +3

Query: 9   ITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCK 188
           IT  IVPGI PI+N+K  ++ +      IP  +      + ++    +  G  +  +M K
Sbjct: 204 ITIDIVPGIFPISNFKQLLKFSSVSNVSIPKWLCCMFHGLDNDLNTSRIIGSSIAIDMVK 263

Query: 189 KILASGIKTLHLYTLNMEKTALAI 260
            + + GI++ H YTLN  + + AI
Sbjct: 264 VLYSEGIRSFHFYTLNKSEISFAI 287

>METF_BUCAP (Q8KA62) 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 292

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 25/90 (27%), Positives = 42/90 (46%)
 Frame = +3

Query: 9   ITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCK 188
           I   I+PGI+PI N++   + +      IP  +    + + ++ E  K  G ++   + K
Sbjct: 203 INIEIIPGILPIYNFEQLKKFSSMTNVSIPKWMFEMFNGLDEDLETQKIIGSNIVINIVK 262

Query: 189 KILASGIKTLHLYTLNMEKTALAILMNLGL 278
            +L  G+K  H YTLN      +I    GL
Sbjct: 263 TLLYEGVKNFHFYTLNKSDVIYSICHMFGL 292

>DSC1_MOUSE (P55849) Desmocollin-1 precursor|
          Length = 886

 Score = 34.3 bits (77), Expect = 0.31
 Identities = 33/119 (27%), Positives = 53/119 (44%), Gaps = 8/119 (6%)
 Frame = +3

Query: 93  IPAEITAALDPIKDN-EEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKTALAILM 266
           +P+ + A     K N EE +K+  + L ++   +IL  G I T H   L+ EK   +IL+
Sbjct: 37  VPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILL 96

Query: 267 NLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIF------WANRPKSYISRTTGWDQYPQ 425
           + G  +E K    +       VFR +    P+       WA  P S +  + G   +PQ
Sbjct: 97  SDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLG--PFPQ 153

>HCF_DROME (Q9V4C8) Host cell factor (dHcf) [Contains: HCF N-terminal chain;|
           HCF C-terminal chain]
          Length = 1500

 Score = 33.9 bits (76), Expect = 0.40
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
 Frame = -1

Query: 402 WSLKCNSLVCW--PRI*GEHPL*HGKH*--LVASKVMFLKAWIPLLIQDSSELLKRSFPC 235
           W L+ +S+  W  P+  GE PL    H   ++ +K+     W+PL+I DS    +R + C
Sbjct: 275 WLLETDSMT-WSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKC 333

>LCAT_ELIQU (O35573) Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43)|
           (Lecithin-cholesterol acyltransferase)
           (Phospholipid-cholesterol acyltransferase) (Fragment)
          Length = 299

 Score = 29.6 bits (65), Expect = 7.6
 Identities = 11/36 (30%), Positives = 23/36 (63%)
 Frame = +3

Query: 222 LYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTN 329
           LY L ++   + I+ ++ L+EE +++ T PW  P++
Sbjct: 134 LYFLLLQPQGIPIMSSIKLVEEQRITTTSPWMFPSH 169


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,451,173
Number of Sequences: 219361
Number of extensions: 2361324
Number of successful extensions: 5951
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 5746
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5932
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5767334219
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)