Clone Name	bags13a21
Clone Library Name	barley_pub

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No.	Definition	Score (bits)	E Value
1	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	110	3e-24
2	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	107	4e-23
3	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	105	1e-22
4	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	102	9e-22
5	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	99	1e-20
6	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	98	2e-20
7	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	97	3e-20
8	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	97	3e-20
9	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	96	7e-20
10	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	95	2e-19
11	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	95	2e-19
12	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	92	1e-18
13	RCC2_MOUSE (Q8BK67) Protein RCC2	90	6e-18
14	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	88	2e-17
15	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	87	3e-17
16	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	87	4e-17
17	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	87	5e-17
18	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	86	7e-17
19	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	85	2e-16
20	RCC1_XENLA (P25183) Regulator of chromosome condensation	84	3e-16
21	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	83	6e-16
22	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	83	8e-16
23	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	80	5e-15
24	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	80	6e-15
25	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	79	1e-14
26	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	78	2e-14
27	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	78	2e-14
28	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	75	1e-13
29	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	74	4e-13
30	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	74	5e-13
31	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	73	8e-13
32	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	69	1e-11
33	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	67	6e-11
34	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	63	6e-10
35	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	62	1e-09
36	RCC1_CANAL (P52499) Protein RCC1	62	1e-09
37	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	62	1e-09
38	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	62	2e-09
39	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	61	2e-09
40	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	60	5e-09
41	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	60	7e-09
42	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	56	1e-07
43	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	55	2e-07
44	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	54	3e-07
45	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	50	4e-06
46	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	47	6e-05
47	FBX24_MOUSE (Q9D417) F-box only protein 24	45	2e-04
48	FBX24_HUMAN (O75426) F-box only protein 24	43	7e-04
49	S12A2_HUMAN (P55011) Solute carrier family 12 member 2 (Bumetani...	33	0.69
50	DAK_BOVIN (Q58DK4) Dihydroxyacetone kinase (EC 2.7.1.29) (Glycer...	32	1.2
51	PWP2_SCHPO (Q9C1X1) Periodic tryptophan protein 2 homolog	32	1.2
52	ERG6_NEUCR (Q9P3R1) Sterol 24-C-methyltransferase (EC 2.1.1.41) ...	31	2.6
53	MKL2_MOUSE (P59759) MKL/myocardin-like protein 2 (Myocardin-rela...	31	3.4
54	MKL2_HUMAN (Q9ULH7) MKL/myocardin-like protein 2 (Myocardin-rela...	31	3.4
55	FREM2_LYTVA (Q9GV77) Extracellular matrix protein 3 precursor (F...	31	3.4
56	YB9W_YEAST (P38352) F-box protein YBR280C	30	4.5
57	KLPA_EMENI (P28739) Kinesin-like protein klpA	30	4.5
58	STC2_STAAU (P17855) Staphylocoagulase precursor	30	5.8
59	MUC_CHICK (P01875) Ig mu chain C region	30	5.8
60	LOXC_ARATH (P38418) Lipoxygenase, chloroplast precursor (EC 1.13...	30	7.6
61	SLP1_SCHPO (P78972) WD-repeat-containing protein slp1	29	10.0

---

>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  110 bits (276), Expect = 3e-24
 Identities = 70/199 (35%), Positives = 106/199 (53%), Gaps = 9/199 (4%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            VH+  +H + ++  G ++++G  + G+LGHG+      P  VEAL+      ++ G  H+
Sbjct: 3078 VHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHS 3137

Query: 181  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--HTLAFTEK 354
             A++S G+LY WG  ++G++G GDN     P  V     ++V QVACG R   TLA TE 
Sbjct: 3138 AAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTED 3197

Query: 355  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSA----AIPFAAKIWV- 519
              VF+WG G  G+LG G     +TP  I+ LS  G G  ++E  A    A+  A ++W  
Sbjct: 3198 GAVFSWGDGDFGKLGRGGSEGSDTPHEIERLS--GIGVVQIECGAQFSLALTRAGEVWTW 3255

Query: 520  SPSERYAL--VPDEKVAKP 570
               + Y L    D+ V KP
Sbjct: 3256 GKGDYYRLGHGGDQHVRKP 3274



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 45/141 (31%), Positives = 78/141 (55%), Gaps = 2/141 (1%)
 Frame = +1

Query: 31   VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGK 204
            V+  G L+  G+   G+LG G  +   +P  + +L+     +++   G +H +ALT++G+
Sbjct: 4097 VTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGE 4156

Query: 205  LYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGT 384
            +Y WG  + G++G G+   +  P  V       VA +ACG  H+ A T   +V  WG+G 
Sbjct: 4157 VYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGR 4216

Query: 385  SGQLGHGEIVDRNTPVIIDAL 447
             G+LGHG+  D+  P +++AL
Sbjct: 4217 YGRLGHGDSEDQLRPKLVEAL 4237



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 53/170 (31%), Positives = 88/170 (51%), Gaps = 2/170 (1%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            V++  +H + +++ G +Y +G  + G+LGHG+   +  P  VE L   S + I+ G  H+
Sbjct: 4141 VNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200

Query: 181  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAFTEK 354
             A+T+ G +  WG  ++G++G GD+ D   P  V      +   +ACG     TL  T+ 
Sbjct: 4201 AAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDD 4260

Query: 355  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFA 504
             NV++WG G  G+LG G       P  I++L+  G G  K+E  +    A
Sbjct: 4261 DNVWSWGDGDYGKLGRGGSDGCKLPYKIESLA--GLGVVKVECGSQFSVA 4308



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 50/146 (34%), Positives = 79/146 (54%), Gaps = 3/146 (2%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALT 192
            H+  +++SG + T+G  +YG+LGHGD ED L P  VEAL       I+   G   T+ +T
Sbjct: 4199 HSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCIT 4258

Query: 193  SDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFA 369
             D  ++ WG   +G++G G  +D C  P ++       V +V CG + ++A T+   V+ 
Sbjct: 4259 DDDNVWSWGDGDYGKLGRG-GSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYT 4317

Query: 370  WGRGTSGQLGHGEIVDRNTPVIIDAL 447
            WG+G   +LGHG +     P  + AL
Sbjct: 4318 WGKGDFHRLGHGSVDHVRRPKKVAAL 4343



 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 2/150 (1%)
 Frame = +1

Query: 4    HAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTM 183
            H   RH + + S+ + Y++G  +  +LGHGD     VP K+ AL+      +  G  ++ 
Sbjct: 622  HCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSA 681

Query: 184  ALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAFTEKK 357
            A+T  G L  WG   + ++G G++ D   P  V    +  V  VA G    H+LA T + 
Sbjct: 682  AITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEG 741

Query: 358  NVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
             VFAWG G  G+LG+G       P+++++L
Sbjct: 742  LVFAWGDGDYGKLGNGNCNGSLQPILVESL 771



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 54/194 (27%), Positives = 90/194 (46%), Gaps = 4/194 (2%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ ++  G+++++G   +G+LG G  E    PH++E L      QI  G + ++ALT  G
Sbjct: 3191 TLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAG 3250

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
            +++ WG   + ++G G +     P  +     ++V  VA G  H LA T+   V+AWG  
Sbjct: 3251 EVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDN 3310

Query: 382  TSGQLGHGEIVDRNTPVII---DALSPDGPGCKKLESSA-AIPFAAKIWVSPSERYALVP 549
              GQ G G       P ++   DA+  +   C    S A  +P A+    S  E+   VP
Sbjct: 3311 DHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNAS----SDEEKRGPVP 3366

Query: 550  DEKVAKPGDATARG 591
                  P   ++ G
Sbjct: 3367 FSSTRDPLGGSSLG 3380



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 42/143 (29%), Positives = 77/143 (53%), Gaps = 1/143 (0%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ ++   +++++G   YG+LG G  +   +P+K+E+L      ++  G + ++ALT  G
Sbjct: 4254 TLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSG 4313

Query: 202  KLYGWGWNKFGQVGAGDNADHC-SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGR 378
             +Y WG   F ++G G + DH   P +V   + +K+  +A G  H +A ++   V+ WG 
Sbjct: 4314 AVYTWGKGDFHRLGHG-SVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGD 4372

Query: 379  GTSGQLGHGEIVDRNTPVIIDAL 447
               GQLG G +     P ++ AL
Sbjct: 4373 NDEGQLGDGTVTAIQRPRLVAAL 4395



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 44/139 (31%), Positives = 72/139 (51%), Gaps = 2/139 (1%)
 Frame = +1

Query: 40   SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 219
            + ++Y +G +  GQLG  +      P   EAL      Q++GG +   A+T DGKL+  G
Sbjct: 4048 ASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATG 4107

Query: 220  WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGTSGQ 393
            +   G++G G +     P  +   +   V +VA   G +H LA T +  V+AWG G  G+
Sbjct: 4108 YGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGK 4167

Query: 394  LGHGEIVDRNTPVIIDALS 450
            LGHG  +  + P +++ L+
Sbjct: 4168 LGHGNRMSYDRPKLVEHLN 4186



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 42/143 (29%), Positives = 78/143 (54%), Gaps = 2/143 (1%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWR 174
            V+    ++  ++  G+L T+G   Y +LGHG+ +D  +P  V AL D     ++   G  
Sbjct: 673  VYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDA 732

Query: 175  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 354
            H++ALTS+G ++ WG   +G++G G+      P  V      +V +V  G + ++A + +
Sbjct: 733  HSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVE--SLPRVQRVFAGSQFSVALSSE 790

Query: 355  KNVFAWGRGTSGQLGHGEIVDRN 423
              ++ WG+ T   LGH ++V+R+
Sbjct: 791  GQLYTWGKATC--LGH-QLVERS 810



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 44/144 (30%), Positives = 67/144 (46%), Gaps = 2/144 (1%)
 Frame = +1

Query: 25  ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW--RHTMALTSD 198
           + +S  G LYT+  +K              P  +E +       I+G    RH +A+ S+
Sbjct: 585 LILSQEGKLYTWRLAK----------PEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSN 634

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGR 378
              Y WG  +  ++G GD      P ++   E+  V  V CG  ++ A T   N+  WGR
Sbjct: 635 HNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGR 694

Query: 379 GTSGQLGHGEIVDRNTPVIIDALS 450
           GT  +LGHG   DR+ P ++ ALS
Sbjct: 695 GTYARLGHGNSDDRSLPTLVVALS 718



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 36/109 (33%), Positives = 58/109 (53%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            ++ ++ SG++YT+G   + +LGHG  +    P KV AL+      I+ G  H +A +  G
Sbjct: 4306 SVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSG 4365

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 348
            ++Y WG N  GQ+G G       P  V   + + + +V CG  HTLA +
Sbjct: 4366 EVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALS 4414



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 2/136 (1%)
 Frame = +1

Query: 46   SLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWN 225
            ++  +G +   QLG        VP   + +       I+GG +    ++ DGK+Y  G  
Sbjct: 2987 TVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEG 3046

Query: 226  KFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGTSGQLG 399
              G++G G   +   P Q+    +  V +VA   G +H LA T    VF+WG G  G+LG
Sbjct: 3047 TNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLG 3106

Query: 400  HGEIVDRNTPVIIDAL 447
            HG     + P +++AL
Sbjct: 3107 HGNRTTLDKPRLVEAL 3122



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 21/59 (35%), Positives = 32/59 (54%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
            H +  S SG +YT+G +  GQLG G       P  V AL+     +++ G  HT+AL++
Sbjct: 4357 HCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALST 4415

---

>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  107 bits (266), Expect = 4e-23
 Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 1/138 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           H + +++ G  +T+G + +GQLG G +F     P +V +L+    +Q++ G  H+ AL+ 
Sbjct: 148 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL 207

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G ++GWG N  GQ+G  D  D  SP  V     QKV  ++CG  HT   T+   VF +G
Sbjct: 208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFG 267

Query: 376 RGTSGQLGHGEIVDRNTP 429
            G+ GQLGH  + D   P
Sbjct: 268 AGSCGQLGHDSMNDEVNP 285



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 52/145 (35%), Positives = 76/145 (52%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHL-VPHKVEALKDSSTSQISGGWRHTMALTS 195
           H++ +S  G L+++G    GQLG    ED + VP  ++ L   +  Q+S G  H +AL +
Sbjct: 95  HSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAA 154

Query: 196 DGKLYGWGWNKFGQVGAGDN-ADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           DG+ + WG N  GQ+G G       SP +V   E   +AQVA G  H+ A +    VF W
Sbjct: 155 DGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGW 214

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG  +  DR +P  +  L
Sbjct: 215 GMNNAGQLGLSDEKDRESPCHVKLL 239



 Score = 84.3 bits (207), Expect(2) = 5e-17
 Identities = 50/144 (34%), Positives = 73/144 (50%), Gaps = 1/144 (0%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           V A   H+  +S SG+++ +G +  GQLG  D +D   P  V+ L+      IS G  HT
Sbjct: 195 VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHT 254

Query: 181 MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 360
             LT  G ++ +G    GQ+G     D  +P +V      +V Q+ACG +HTLAF     
Sbjct: 255 AVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSG 314

Query: 361 -VFAWGRGTSGQLGHGEIVDRNTP 429
            ++A+G G  GQLG G   +   P
Sbjct: 315 LIYAFGCGARGQLGTGHTCNVKCP 338



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 43/131 (32%), Positives = 67/131 (51%), Gaps = 1/131 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H++ +   G +YT G +  GQLGH    +   P ++ AL D     ++ G  H++AL+  
Sbjct: 45  HSVFLLEDGEVYTCGLNTKGQLGHE--REGNKPEQIGALADQHIIHVACGESHSLALSDR 102

Query: 199 GKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G+L+ WG    GQ+G     D  + P  +    +Q + QV+CG  H LA       F WG
Sbjct: 103 GQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG 162

Query: 376 RGTSGQLGHGE 408
           + + GQLG G+
Sbjct: 163 KNSHGQLGLGK 173



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 37/116 (31%), Positives = 60/116 (51%), Gaps = 2/116 (1%)
 Frame = +1

Query: 58  YGWSKYGQLGHGDFEDHLV--PHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 231
           +G+   GQ G       +V  P     + D S  +++ G  H++ L  DG++Y  G N  
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 232 GQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
           GQ+G     +   P Q+    +Q +  VACG  H+LA +++  +F+WG G+ GQLG
Sbjct: 64  GQLGHEREGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 32/89 (35%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALT-S 195
           HT  ++ SG ++T+G    GQLGH    D + P +V  L  S  +QI+ G +HT+A   S
Sbjct: 253 HTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPS 312

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQV 282
            G +Y +G    GQ+G G   +   P+ V
Sbjct: 313 SGLIYAFGCGARGQLGTGHTCNVKCPSPV 341



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
 Frame = +1

Query: 214 WGWNKFGQVGAGDNADH--CSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTS 387
           WG+   GQ G   N       P    F  ++ V +VACG  H++   E   V+  G  T 
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 388 GQLGHGEIVDRNTPVIIDALS 450
           GQLGH    + N P  I AL+
Sbjct: 64  GQLGHER--EGNKPEQIGALA 82



 Score = 22.7 bits (47), Expect(2) = 5e-17
 Identities = 9/24 (37%), Positives = 13/24 (54%), Gaps = 1/24 (4%)
 Frame = +3

Query: 423 HTCDY*CPKPRRS-WLQEAGVFSS 491
           HTC+  CP P +  W   +G  S+
Sbjct: 331 HTCNVKCPSPVKGYWAAHSGQLSA 354

---

>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  105 bits (262), Expect = 1e-22
 Identities = 63/170 (37%), Positives = 89/170 (52%), Gaps = 2/170 (1%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            VH+  RH   ++  G ++++G    G+LGH    +   P  +EALK      I+ G  H+
Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHS 3111

Query: 181  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--HTLAFTEK 354
             ALTS G+LY WG  ++G++G GDN     P  V      +V QVACG R   TLA T++
Sbjct: 3112 AALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDE 3171

Query: 355  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFA 504
              VF+WG G  G+LG G     N P  I+ L  +G G  ++E  A    A
Sbjct: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERL--NGQGVCQIECGAQFSLA 3219



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 53/170 (31%), Positives = 90/170 (52%), Gaps = 2/170 (1%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            V++  +H + +SS G +Y++G ++ G+LGHG+      P  +E+L+      ++ G  H+
Sbjct: 4044 VNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHS 4103

Query: 181  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAFTEK 354
              +T+ G LY WG  ++G++G  D+ D   P  V   +  +V  +ACG     TL  T+ 
Sbjct: 4104 ACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD 4163

Query: 355  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFA 504
              V++WG G  G+LG G       P+ ID+L+  G G  K+E  +    A
Sbjct: 4164 DTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLT--GLGVVKVECGSQFSVA 4211



 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 51/138 (36%), Positives = 78/138 (56%), Gaps = 3/138 (2%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWR 174
            V A   H+  V+++G LYT+G  +YG+LGH D ED L P  VEAL+      I+   G  
Sbjct: 4096 VAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDA 4155

Query: 175  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
             T+ LT D  ++ WG   +G++G G  +D C  P +++      V +V CG + ++A T+
Sbjct: 4156 QTLCLTDDDTVWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214

Query: 352  KKNVFAWGRGTSGQLGHG 405
               V+ WG+G   +LGHG
Sbjct: 4215 SGAVYTWGKGDYHRLGHG 4232



 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 44/145 (30%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALT 192
           ++  +++ G LYT+G   YG+LGHG  ED  +P  V  LK      ++   G   T+A+T
Sbjct: 562 YSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVT 621

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
            +G+++ WG   +G++G G +    +P  +   ++  V +V CG + ++A T+   V++W
Sbjct: 622 ENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSW 681

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G+G + +LGHG       P +++ L
Sbjct: 682 GKGDNQRLGHGTEEHVRYPKLLEGL 706



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 51/154 (33%), Positives = 80/154 (51%), Gaps = 6/154 (3%)
 Frame = +1

Query: 4   HAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ----ISGGW 171
           H+   H + ++++G +Y++G    G+LGHGD      P  + A       +    I+ G 
Sbjct: 501 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 560

Query: 172 RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAF 345
            ++ A+T++G+LY WG   +G++G G + D   P  V   +  KV  VACG     TLA 
Sbjct: 561 TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 620

Query: 346 TEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
           TE   V++WG G  G+LG G      TP +I+ L
Sbjct: 621 TENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKL 654



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 42/142 (29%), Positives = 69/142 (48%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ ++  G ++++G   +G+LG G  E   +P  +E L      QI  G + ++ALT  G
Sbjct: 3165 TLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSG 3224

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
             ++ WG   + ++G G +     P  V     +K+  VA G  H LA T+   V+AWG  
Sbjct: 3225 VVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3284

Query: 382  TSGQLGHGEIVDRNTPVIIDAL 447
              GQ G+G       P ++  L
Sbjct: 3285 DHGQQGNGTTTVNRKPTLVQGL 3306



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 46/144 (31%), Positives = 75/144 (52%), Gaps = 2/144 (1%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T++   SG++Y +G +  GQLG  +     VP   EAL      Q+ GG +   A+T+DG
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4004

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVA--CGWRHTLAFTEKKNVFAWG 375
            KLY  G+   G++G G      +P  +   +   + +VA   G +H LA + +  V++WG
Sbjct: 4005 KLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWG 4064

Query: 376  RGTSGQLGHGEIVDRNTPVIIDAL 447
                G+LGHG     + P +I++L
Sbjct: 4065 EAEDGKLGHGNRSPCDRPRVIESL 4088



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 42/142 (29%), Positives = 72/142 (50%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ ++   +++++G   YG+LG G  +   VP K+++L      ++  G + ++ALT  G
Sbjct: 4157 TLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSG 4216

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
             +Y WG   + ++G G +     P QV   + +KV  +A G  H +  TE   V+ WG  
Sbjct: 4217 AVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDN 4276

Query: 382  TSGQLGHGEIVDRNTPVIIDAL 447
              GQLG G       P ++ AL
Sbjct: 4277 DEGQLGDGTTNAIQRPRLVAAL 4298



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 41/142 (28%), Positives = 71/142 (50%), Gaps = 3/142 (2%)
 Frame = +1

Query: 31   VSSSGSLYTYGWSKYGQLGHGDFEDHL-VPHKVEALKDSSTSQIS--GGWRHTMALTSDG 201
            V+  G +Y  G +  G+LG G     + +P ++ AL      +++   G RH  ALT DG
Sbjct: 3007 VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDG 3066

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
            K++ WG    G++G     +   P  +   + +++  +ACG  H+ A T    ++ WG G
Sbjct: 3067 KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3126

Query: 382  TSGQLGHGEIVDRNTPVIIDAL 447
              G+LGHG+   +  P ++  L
Sbjct: 3127 EYGRLGHGDNTTQLKPKMVKVL 3148



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 40/112 (35%), Positives = 62/112 (55%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            ++ ++ SG++YT+G   Y +LGHG  +    P +V+ L+      I+ G  H +  T DG
Sbjct: 4209 SVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDG 4268

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 357
            ++Y WG N  GQ+G G       P  V   + +KV +VACG  HTLA++  K
Sbjct: 4269 EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK 4320



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 38/109 (34%), Positives = 59/109 (54%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            ++ ++ SG ++T+G   Y +LGHG       P  VE L+      ++ G  H +A+T  G
Sbjct: 3217 SLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSG 3276

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 348
            ++Y WG N  GQ G G    +  P  V   E QK+ +VACG  H++A+T
Sbjct: 3277 QVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 49/170 (28%), Positives = 81/170 (47%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ V+ +G ++++G   YG+LG G  +    P  +E L+D    ++  G + ++ALT DG
Sbjct: 617  TLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDG 676

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
            ++Y WG     ++G G       P  +   + +KV  VA G  H LA TE   V +W  G
Sbjct: 677  QVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSW--G 734

Query: 382  TSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFAAKIWVSPSE 531
            ++ Q  H + +    P   +  +  G   K +   A  P  +  W S SE
Sbjct: 735  SNDQCQHFDTLRVTKP---EPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 43/136 (31%), Positives = 67/136 (49%), Gaps = 3/136 (2%)
 Frame = +1

Query: 49   LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 228
            ++ +G +   QLG        VP   E L   +  Q++GG +   A+T +GK+Y  G   
Sbjct: 2961 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEAT 3020

Query: 229  FGQVGAGDNADHCS-PAQVNFPEEQKVAQVA--CGWRHTLAFTEKKNVFAWGRGTSGQLG 399
             G++G G ++     P Q+       V +VA   G RH  A T    VF+WG G  G+LG
Sbjct: 3021 NGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLG 3080

Query: 400  HGEIVDRNTPVIIDAL 447
            H   ++ + P +I+AL
Sbjct: 3081 HFSRMNCDKPRLIEAL 3096



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 41/163 (25%), Positives = 71/163 (43%), Gaps = 3/163 (1%)
 Frame = +1

Query: 34  SSSGSLY-TYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 210
           S  GSL    GW   G +G   + + + P + E L +   +QI+   +  + L+ +G++Y
Sbjct: 417 SHKGSLQEVIGW---GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVY 473

Query: 211 GWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGT 384
              +N          +D  +P  V     + + ++A      H LA      V++WG G 
Sbjct: 474 TQAYN----------SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGD 523

Query: 385 SGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFAAKI 513
            G+LGHG+ V    P +I A S    G   +  +    ++A I
Sbjct: 524 GGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAI 566



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 17/59 (28%), Positives = 34/59 (57%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
            H + V+ SG +Y +G + +GQ G+G    +  P  V+ L+    ++++ G  H++A T+
Sbjct: 3268 HCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 18/56 (32%), Positives = 29/56 (51%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMA 186
            H +  +  G +YT+G +  GQLG G       P  V AL+    ++++ G  HT+A
Sbjct: 4260 HCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4315

---

>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  102 bits (254), Expect = 9e-22
 Identities = 61/170 (35%), Positives = 88/170 (51%), Gaps = 2/170 (1%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            VH+  RH   ++  G ++++G    G+LGH    +   P  ++ALK      I+ G  H+
Sbjct: 3053 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHS 3112

Query: 181  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--HTLAFTEK 354
              LTS G+LY WG  ++G++G GDN     P  V      +V QVACG R   TLA T++
Sbjct: 3113 APLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDE 3172

Query: 355  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFA 504
              VF+WG G  G+LG G     N P  I+ L  +G G  ++E  A    A
Sbjct: 3173 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERL--NGQGVCQIECGAQFSLA 3220



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 53/170 (31%), Positives = 90/170 (52%), Gaps = 2/170 (1%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            V++  +H + +SS G +Y++G ++ G+LGHG+      P  +E+L+      ++ G  H+
Sbjct: 4046 VNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHS 4105

Query: 181  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAFTEK 354
              +T+ G LY WG  ++G++G  D+ D   P  V   +  +V  +ACG     TL  T+ 
Sbjct: 4106 ACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDD 4165

Query: 355  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFA 504
              V++WG G  G+LG G       P+ ID+L+  G G  K+E  +    A
Sbjct: 4166 DTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLT--GLGVVKVECGSQFSVA 4213



 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 51/138 (36%), Positives = 78/138 (56%), Gaps = 3/138 (2%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWR 174
            V A   H+  V+++G LYT+G  +YG+LGH D ED L P  VEAL+      I+   G  
Sbjct: 4098 VAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDA 4157

Query: 175  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
             T+ LT D  ++ WG   +G++G G  +D C  P +++      V +V CG + ++A T+
Sbjct: 4158 QTLCLTDDDTVWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4216

Query: 352  KKNVFAWGRGTSGQLGHG 405
               V+ WG+G   +LGHG
Sbjct: 4217 SGAVYTWGKGDYHRLGHG 4234



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 44/145 (30%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALT 192
           ++  +++ G LYT+G   YG+LGHG  ED  +P  V  LK      ++   G   T+A+T
Sbjct: 563 YSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVT 622

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
            +G+++ WG   +G++G G +    +P  +   ++  V +V CG + ++A T+   V++W
Sbjct: 623 ENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSW 682

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G+G + +LGHG       P +++ L
Sbjct: 683 GKGDNQRLGHGTEEHVRYPKLLEGL 707



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 51/154 (33%), Positives = 80/154 (51%), Gaps = 6/154 (3%)
 Frame = +1

Query: 4   HAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ----ISGGW 171
           H+   H + ++++G +Y++G    G+LGHGD      P  + A       +    I+ G 
Sbjct: 502 HSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS 561

Query: 172 RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAF 345
            ++ A+T++G+LY WG   +G++G G + D   P  V   +  KV  VACG     TLA 
Sbjct: 562 TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAV 621

Query: 346 TEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
           TE   V++WG G  G+LG G      TP +I+ L
Sbjct: 622 TENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKL 655



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 42/142 (29%), Positives = 69/142 (48%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ ++  G ++++G   +G+LG G  E   +P  +E L      QI  G + ++ALT  G
Sbjct: 3166 TLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSG 3225

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
             ++ WG   + ++G G +     P  V     +K+  VA G  H LA T+   V+AWG  
Sbjct: 3226 VVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3285

Query: 382  TSGQLGHGEIVDRNTPVIIDAL 447
              GQ G+G       P ++  L
Sbjct: 3286 DHGQQGNGTTTVNRKPTLVQGL 3307



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 46/144 (31%), Positives = 75/144 (52%), Gaps = 2/144 (1%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T++   SG++Y +G +  GQLG  +     VP   EAL      Q+ GG +   A+T+DG
Sbjct: 3947 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4006

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVA--CGWRHTLAFTEKKNVFAWG 375
            KLY  G+   G++G G      +P  +   +   + +VA   G +H LA + +  V++WG
Sbjct: 4007 KLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWG 4066

Query: 376  RGTSGQLGHGEIVDRNTPVIIDAL 447
                G+LGHG     + P +I++L
Sbjct: 4067 EAEDGKLGHGNRSPCDRPRVIESL 4090



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 42/142 (29%), Positives = 72/142 (50%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ ++   +++++G   YG+LG G  +   VP K+++L      ++  G + ++ALT  G
Sbjct: 4159 TLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSG 4218

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
             +Y WG   + ++G G +     P QV   + +KV  +A G  H +  TE   V+ WG  
Sbjct: 4219 AVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDN 4278

Query: 382  TSGQLGHGEIVDRNTPVIIDAL 447
              GQLG G       P ++ AL
Sbjct: 4279 DEGQLGDGTTNAIQRPRLVAAL 4300



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 40/112 (35%), Positives = 62/112 (55%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            ++ ++ SG++YT+G   Y +LGHG  +    P +V+ L+      I+ G  H +  T DG
Sbjct: 4211 SVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDG 4270

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 357
            ++Y WG N  GQ+G G       P  V   + +KV +VACG  HTLA++  K
Sbjct: 4271 EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK 4322



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 38/109 (34%), Positives = 59/109 (54%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            ++ ++ SG ++T+G   Y +LGHG       P  VE L+      ++ G  H +A+T  G
Sbjct: 3218 SLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSG 3277

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 348
            ++Y WG N  GQ G G    +  P  V   E QK+ +VACG  H++A+T
Sbjct: 3278 QVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3326



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 48/170 (28%), Positives = 80/170 (47%)
 Frame = +1

Query: 22   TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
            T+ V+ +G ++++G   YG+LG G  +    P  +E L+D    ++  G + ++ALT DG
Sbjct: 618  TLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDG 677

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
            ++Y WG     ++G G       P  +   + +KV  VA G  H L  TE   V +W  G
Sbjct: 678  QVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLVLTEDSEVHSW--G 735

Query: 382  TSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFAAKIWVSPSE 531
            ++ Q  H + +    P   +  +  G   K +   A  P  +  W S SE
Sbjct: 736  SNDQCQHFDTLGVTKP---EPTAFPGLDSKHIVGIACGPAQSFAWSSCSE 782



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 39/142 (27%), Positives = 70/142 (49%), Gaps = 3/142 (2%)
 Frame = +1

Query: 31   VSSSGSLYTYGWSKYGQLGHGDFEDHL-VPHKVEALKDSSTSQIS--GGWRHTMALTSDG 201
            V+  G +Y+ G +  G+LG G     + +P ++ AL      +++   G RH  ALT DG
Sbjct: 3008 VTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDG 3067

Query: 202  KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
            K++ WG    G++G     +   P  +   + +++  +A G  H+   T    ++ WG G
Sbjct: 3068 KVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLG 3127

Query: 382  TSGQLGHGEIVDRNTPVIIDAL 447
              G+LGHG+   +  P ++  L
Sbjct: 3128 EYGRLGHGDNTTQLKPKMVKVL 3149



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 3/143 (2%)
 Frame = +1

Query: 28   TVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKL 207
            T +    ++ +G +   QLG        VP   E L   +  Q++GG +   A+T +GK+
Sbjct: 2955 TATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKV 3014

Query: 208  YGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVA--CGWRHTLAFTEKKNVFAWGR 378
            Y  G    G++G G ++     P Q+       V +VA   G RH  A T    VF+WG 
Sbjct: 3015 YSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE 3074

Query: 379  GTSGQLGHGEIVDRNTPVIIDAL 447
            G  G+LGH   ++ + P +I AL
Sbjct: 3075 GDDGKLGHFSRMNCDKPRLIQAL 3097



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 40/163 (24%), Positives = 69/163 (42%), Gaps = 3/163 (1%)
 Frame = +1

Query: 34  SSSGSLY-TYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 210
           S  GSL    GW   G +G   + + + P + E L      Q++   +  + L+ +G++Y
Sbjct: 418 SHKGSLQEVIGW---GLIGWKYYANVIGPIQCEGLASLGVMQVACAEKRFLILSRNGRVY 474

Query: 211 GWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGT 384
              +N          +D  +P  V     + + ++A      H LA      V++WG G 
Sbjct: 475 TQAYN----------SDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGD 524

Query: 385 SGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFAAKI 513
            G+LGHG+ V    P +I A S    G   +  +    ++A I
Sbjct: 525 GGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAI 567



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 17/59 (28%), Positives = 34/59 (57%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
            H + V+ SG +Y +G + +GQ G+G    +  P  V+ L+    ++++ G  H++A T+
Sbjct: 3269 HCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3327



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 18/56 (32%), Positives = 29/56 (51%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMA 186
            H +  +  G +YT+G +  GQLG G       P  V AL+    ++++ G  HT+A
Sbjct: 4262 HCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4317

---

>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 1/130 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 195
           H++ +++ G L+ +G++  GQ+G G   +   P KV   L       I+ G   +MA+  
Sbjct: 139 HSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLD 198

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G++YGWG+N  GQ+G G+N +  +P +V       V Q+ CG+ HTLA T++  ++AWG
Sbjct: 199 SGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWG 258

Query: 376 RGTSGQLGHG 405
             T GQLG G
Sbjct: 259 ANTYGQLGTG 268



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 50/145 (34%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 195
           H +  +  G +Y +G + Y QLG+G     + P +V   L      +++ G  H+MAL +
Sbjct: 86  HVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAA 145

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQV-NFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           DG+L+ WG+N  GQVG+G  A+  +P +V N    ++V  +ACG   ++A  +   V+ W
Sbjct: 146 DGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGW 205

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG G   ++ TPV + AL
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRVAAL 230



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 51/130 (39%), Positives = 74/130 (56%), Gaps = 3/130 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           ++ V  SG +Y +G++  GQLG G+  + L P +V AL     +QI  G+ HT+ALT +G
Sbjct: 193 SMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEG 252

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 375
            LY WG N +GQ+G G   +  SP Q+   +E+ +   AC   HT  A T+  +V+ WG 
Sbjct: 253 LLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHVYMWGQ 312

Query: 376 -RGTSGQLGH 402
            RG S  L H
Sbjct: 313 CRGQSVILPH 322



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 49/138 (35%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
 Frame = +1

Query: 25  ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDG 201
           I V+ +  ++ +G +    LG GD +  LVP K+EAL       +S G   H +  T DG
Sbjct: 35  IYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLTTEDG 94

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            +Y WG N + Q+G G      +P QV  N   +Q V +VACG  H++A      +FAWG
Sbjct: 95  VVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VIEVACGSHHSMALAADGELFAWG 153

Query: 376 RGTSGQLGHGEIVDRNTP 429
               GQ+G G   ++ TP
Sbjct: 154 YNNCGQVGSGSTANQPTP 171



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
 Frame = +1

Query: 13  WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL- 189
           + HT+ ++  G LY +G + YGQLG G   + L P ++   K+      +    HT A  
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAACHSTHTSAAK 301

Query: 190 TSDGKLYGWG 219
           T  G +Y WG
Sbjct: 302 TQGGHVYMWG 311

---

>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 52/144 (36%), Positives = 75/144 (52%), Gaps = 1/144 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           H++ +S  G L+ +G + +GQLG G  F     P  VE L     +QIS G  H+MAL+ 
Sbjct: 149 HSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSM 208

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G +Y WG N+ GQ+G G       P+ +   + QKV  VACG  H+   T+   +F +G
Sbjct: 209 SGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFG 268

Query: 376 RGTSGQLGHGEIVDRNTPVIIDAL 447
            G  GQLGH    +   P ++  L
Sbjct: 269 AGKHGQLGHNSTQNELRPCLVAEL 292



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 51/153 (33%), Positives = 82/153 (53%), Gaps = 1/153 (0%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           + A   H++ +S SG++Y++G ++ GQLG G  E    P  +E L +     ++ G  H+
Sbjct: 196 ISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHS 255

Query: 181 MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF-TEKK 357
             LT DG L+ +G  K GQ+G     +   P  V      +V Q+ACG  HTLA+ ++  
Sbjct: 256 ALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLG 315

Query: 358 NVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 456
            VF++G G  GQLG+G   D+  P+ +   S +
Sbjct: 316 KVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSE 348



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 43/143 (30%), Positives = 70/143 (48%), Gaps = 12/143 (8%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H+  ++  G L+T+G  K+GQLGH   ++ L P  V  L     +QI+ G  HT+A  SD
Sbjct: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSD 313

Query: 199 -GKLYGWGWNKFGQVGAGDNADHCSPAQV-----------NFPEEQKVAQVACGWRHTLA 342
            GK++ +G  K GQ+G G   D   P  V           +   E+++  +A G +  L 
Sbjct: 314 LGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILL 373

Query: 343 FTEKKNVFAWGRGTSGQLGHGEI 411
           + +K+N +   + T   L  G +
Sbjct: 374 WIKKENSYVNLKRTIPTLNEGTV 396



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
 Frame = +1

Query: 115 PHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP- 291
           P  ++  K+     +  G  H + L+SDGK + +              D+ S   + F  
Sbjct: 88  PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEY--------------DNYSMKHLRFES 133

Query: 292 --EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHG-EIVDRNTPVIIDALS 450
             +E+K+ Q+ CG  H+LA ++   +FAWG+   GQLG G +     TP I++ L+
Sbjct: 134 ILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLA 189

---

>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 46/144 (31%), Positives = 87/144 (60%), Gaps = 3/144 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
           H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I+ G   +MA+  
Sbjct: 163 HSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVD 222

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G++Y WG+N  GQ+G G + +  +P +V   +  +V +VACG+ HTL  T++  ++AWG
Sbjct: 223 TGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWG 282

Query: 376 RGTSGQLGHGEIVDRN--TPVIID 441
             + GQLG G   +++  TPV+++
Sbjct: 283 ANSYGQLGTGNKSNQSYPTPVVVE 306



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 50/145 (34%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTS 195
           H +  ++ G ++T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTS
Sbjct: 110 HIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVA-QVACGWRHTLAFTEKKNVFAW 372
           DG+++ WG+N  GQVG+G  A+   P +V    + KV   +ACG   ++A  +   V+ W
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVW 229

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG G   ++ TP  + AL
Sbjct: 230 GYNGNGQLGLGSSGNQPTPCRVAAL 254



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 42/130 (32%), Positives = 73/130 (56%), Gaps = 3/130 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           ++ V  +G +Y +G++  GQLG G   +   P +V AL+     +++ G+ HT+ LT +G
Sbjct: 217 SMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG 276

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 375
           ++Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A ++  +V+ WG 
Sbjct: 277 QIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKSQGGHVYMWGQ 336

Query: 376 -RGTSGQLGH 402
            RG S  L H
Sbjct: 337 CRGQSVILPH 346



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 40/129 (31%), Positives = 67/129 (51%), Gaps = 2/129 (1%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 225
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T+DG+++ WG N
Sbjct: 67  IFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHN 126

Query: 226 KFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 402
            + Q+G G       P  ++     ++V +VACG  H+L  T    VFAWG   SGQ+G 
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186

Query: 403 GEIVDRNTP 429
           G   ++  P
Sbjct: 187 GSTANQPIP 195



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           V   + HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT
Sbjct: 262 VACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHT 321

Query: 181 MALTSD-GKLYGWG 219
            A  S  G +Y WG
Sbjct: 322 SAAKSQGGHVYMWG 335



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
 Frame = +1

Query: 190 TSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACG-WRHTLAFTEKKNVF 366
           T + +++  G N  G +G GD      P +++    +K+A ++ G   H +  T    VF
Sbjct: 62  TVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVF 121

Query: 367 AWGRGTSGQLGHG 405
            WG     QLG+G
Sbjct: 122 TWGHNAYSQLGNG 134

---

>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 46/144 (31%), Positives = 87/144 (60%), Gaps = 3/144 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
           H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I+ G   +MA+  
Sbjct: 163 HSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVD 222

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G++Y WG+N  GQ+G G + +  +P +V   +  +V +VACG+ HTL  T++  ++AWG
Sbjct: 223 TGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWG 282

Query: 376 RGTSGQLGHGEIVDRN--TPVIID 441
             + GQLG G   +++  TPV+++
Sbjct: 283 ANSYGQLGTGNKSNQSYPTPVVVE 306



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 50/145 (34%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTS 195
           H +  ++ G ++T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTS
Sbjct: 110 HIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVA-QVACGWRHTLAFTEKKNVFAW 372
           DG+++ WG+N  GQVG+G  A+   P +V    + KV   +ACG   ++A  +   V+ W
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVW 229

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG G   ++ TP  + AL
Sbjct: 230 GYNGNGQLGLGSSGNQPTPCRVAAL 254



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 43/130 (33%), Positives = 73/130 (56%), Gaps = 3/130 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           ++ V  +G +Y +G++  GQLG G   +   P +V AL+     +++ G+ HT+ LT +G
Sbjct: 217 SMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG 276

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 375
           ++Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A T+  +V+ WG 
Sbjct: 277 QIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQ 336

Query: 376 -RGTSGQLGH 402
            RG S  L H
Sbjct: 337 CRGQSVILPH 346



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 40/129 (31%), Positives = 67/129 (51%), Gaps = 2/129 (1%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 225
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T+DG+++ WG N
Sbjct: 67  IFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHN 126

Query: 226 KFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 402
            + Q+G G       P  ++     ++V +VACG  H+L  T    VFAWG   SGQ+G 
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186

Query: 403 GEIVDRNTP 429
           G   ++  P
Sbjct: 187 GSTANQPIP 195



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           V   + HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT
Sbjct: 262 VACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHT 321

Query: 181 MAL-TSDGKLYGWG 219
            A  T  G +Y WG
Sbjct: 322 SAAKTQGGHVYMWG 335



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
 Frame = +1

Query: 190 TSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACG-WRHTLAFTEKKNVF 366
           T + +++  G N  G +G GD      P +++    +K+A ++ G   H +  T    VF
Sbjct: 62  TVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVF 121

Query: 367 AWGRGTSGQLGHG 405
            WG     QLG+G
Sbjct: 122 TWGHNAYSQLGNG 134

---

>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 46/130 (35%), Positives = 76/130 (58%), Gaps = 1/130 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 195
           H++ +++ G ++ +G++  GQ+G G   +   P KV   L       I+ G   +MA+  
Sbjct: 139 HSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLD 198

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           +G++YGWG+N  GQ+G G+N +  +P +V       V Q+ CG+ HTLA T++  ++AWG
Sbjct: 199 NGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258

Query: 376 RGTSGQLGHG 405
             T GQLG G
Sbjct: 259 ANTYGQLGTG 268



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 49/145 (33%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 195
           H +  +  G +Y +G + Y QLG+G     + P +V   L      +++ G  H+MAL +
Sbjct: 86  HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQV-NFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           DG+++ WG+N  GQVG+G  A+  +P +V N    ++V  +ACG   ++A  +   V+ W
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGW 205

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG G   ++ TPV + AL
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRVAAL 230



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 51/130 (39%), Positives = 75/130 (57%), Gaps = 3/130 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           ++ V  +G +Y +G++  GQLG G+  + L P +V AL     +QI  G+ HT+ALT +G
Sbjct: 193 SMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 375
            LY WG N +GQ+G G+  +  SPA +   +E+ V   AC   HT  A T+  +V+ WG 
Sbjct: 253 LLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312

Query: 376 -RGTSGQLGH 402
            RG S  L H
Sbjct: 313 CRGQSVILPH 322



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 48/136 (35%), Positives = 69/136 (50%), Gaps = 3/136 (2%)
 Frame = +1

Query: 31  VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKL 207
           V+ +  ++ +G +    LG GD +  LVP K+E L       +S G   H +  T DG +
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96

Query: 208 YGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           Y WG N + Q+G G      +P QV  N   +Q V +VACG  H++A      VFAWG  
Sbjct: 97  YAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VVEVACGSHHSMALAADGEVFAWGYN 155

Query: 382 TSGQLGHGEIVDRNTP 429
             GQ+G G   ++ TP
Sbjct: 156 NCGQVGSGSTANQPTP 171



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
 Frame = +1

Query: 13  WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL- 189
           + HT+ ++  G LY +G + YGQLG G+  + L P  +   K+      +    HT A  
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAK 301

Query: 190 TSDGKLYGWG 219
           T  G +Y WG
Sbjct: 302 TQGGHVYMWG 311

---

>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 47/144 (32%), Positives = 86/144 (59%), Gaps = 3/144 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
           H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I+ G    MA+  
Sbjct: 163 HSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVD 222

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G++Y WG+N  GQ+G G++ +  +P +V   +  +V +VACG+ HTL  T++  V+AWG
Sbjct: 223 TGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWG 282

Query: 376 RGTSGQLGHGEIVDRN--TPVIID 441
             + GQLG G   +++  TPV ++
Sbjct: 283 ANSYGQLGTGNKSNQSYPTPVTVE 306



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 49/145 (33%), Positives = 79/145 (54%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTS 195
           H +  ++ G ++T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTS
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK-VAQVACGWRHTLAFTEKKNVFAW 372
           DG+++ WG+N  GQVG+G   +   P +V    + K V  +ACG    +A  +   V+ W
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG G   ++ TP  + AL
Sbjct: 230 GYNGNGQLGLGNSGNQPTPCRVAAL 254



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 43/129 (33%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
 Frame = +1

Query: 25  ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 204
           + V  +G +Y +G++  GQLG G+  +   P +V AL+     +++ G+ HT+ LT +G+
Sbjct: 218 MAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQ 277

Query: 205 LYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG-- 375
           +Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A T+  +V+ WG  
Sbjct: 278 VYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQC 337

Query: 376 RGTSGQLGH 402
           RG S  L H
Sbjct: 338 RGQSVILPH 346



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 40/129 (31%), Positives = 68/129 (52%), Gaps = 2/129 (1%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 225
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T++G+++ WG N
Sbjct: 67  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126

Query: 226 KFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 402
            + Q+G G       P  ++     ++V +VACG  H+L  T    VFAWG   SGQ+G 
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186

Query: 403 GEIVDRNTP 429
           G  V++  P
Sbjct: 187 GSTVNQPIP 195



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           V   + HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT
Sbjct: 262 VACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHT 321

Query: 181 MAL-TSDGKLYGWG 219
            A  T  G +Y WG
Sbjct: 322 SAAKTQGGHVYMWG 335

---

>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 47/144 (32%), Positives = 86/144 (59%), Gaps = 3/144 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
           H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I+ G    MA+  
Sbjct: 163 HSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVD 222

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G++Y WG+N  GQ+G G++ +  +P +V   +  +V +VACG+ HTL  T++  V+AWG
Sbjct: 223 TGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWG 282

Query: 376 RGTSGQLGHGEIVDRN--TPVIID 441
             + GQLG G   +++  TPV ++
Sbjct: 283 ANSYGQLGTGNKSNQSYPTPVTVE 306



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 49/145 (33%), Positives = 79/145 (54%), Gaps = 2/145 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTS 195
           H +  ++ G ++T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTS
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK-VAQVACGWRHTLAFTEKKNVFAW 372
           DG+++ WG+N  GQVG+G   +   P +V    + K V  +ACG    +A  +   V+ W
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229

Query: 373 GRGTSGQLGHGEIVDRNTPVIIDAL 447
           G   +GQLG G   ++ TP  + AL
Sbjct: 230 GYNGNGQLGLGNSGNQPTPCRVAAL 254



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 43/129 (33%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
 Frame = +1

Query: 25  ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 204
           + V  +G +Y +G++  GQLG G+  +   P +V AL+     +++ G+ HT+ LT +G+
Sbjct: 218 MAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQ 277

Query: 205 LYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG-- 375
           +Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A T+  +V+ WG  
Sbjct: 278 VYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQC 337

Query: 376 RGTSGQLGH 402
           RG S  L H
Sbjct: 338 RGQSVILPH 346



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 40/129 (31%), Positives = 68/129 (52%), Gaps = 2/129 (1%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 225
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T++G+++ WG N
Sbjct: 67  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126

Query: 226 KFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 402
            + Q+G G       P  ++     ++V +VACG  H+L  T    VFAWG   SGQ+G 
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186

Query: 403 GEIVDRNTP 429
           G  V++  P
Sbjct: 187 GSTVNQPIP 195



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           V   + HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT
Sbjct: 262 VACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHT 321

Query: 181 MAL-TSDGKLYGWG 219
            A  T  G +Y WG
Sbjct: 322 SAAKTQGGHVYMWG 335

---

>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 49/129 (37%), Positives = 77/129 (59%), Gaps = 1/129 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H++ ++  G L+++G +  GQLGHGD +   VP  +E+LK       + G  HT+ALT +
Sbjct: 152 HSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTEN 211

Query: 199 GKLYGWGWNKFGQVGAGDNADHC-SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G +Y +G NK GQ+G G+  D   SPAQ+ +   Q + +VACG   ++    K N++++G
Sbjct: 212 GSVYAFGENKMGQLGLGNKTDAVPSPAQILY-NGQPITKVACGAEFSMIMDCKGNLYSFG 270

Query: 376 RGTSGQLGH 402
               GQLGH
Sbjct: 271 CPEYGQLGH 279



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 57/195 (29%), Positives = 91/195 (46%), Gaps = 27/195 (13%)
 Frame = +1

Query: 1   VHAXW--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST-SQISGGW 171
           VHA     HT+ ++ +GS+Y +G +K GQLG G+  D  VP   + L +    ++++ G 
Sbjct: 196 VHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTD-AVPSPAQILYNGQPITKVACGA 254

Query: 172 RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQK--- 303
             +M +   G LY +G  ++GQ+G   +  + + AQ               F E+ K   
Sbjct: 255 EFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQ 314

Query: 304 --------VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDG 459
                   V  +ACG  H+L    +K VF+WG G  G+LGH E  D   P ++      G
Sbjct: 315 ILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPG 374

Query: 460 PGCKKLESSAAIPFA 504
            G  ++ + A   FA
Sbjct: 375 RGAAQIYAGATCSFA 389



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 2/103 (1%)
 Frame = +1

Query: 115 PHKVEALKDSSTSQISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 288
           PH+   L       ++ G    H++ +T +GKL+ WG N  GQ+G GD      P  +  
Sbjct: 130 PHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIES 189

Query: 289 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
            + +     ACG  HTLA TE  +V+A+G    GQLG G   D
Sbjct: 190 LKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTD 232



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/158 (23%), Positives = 70/158 (44%), Gaps = 11/158 (6%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK--DSSTSQISGGWRHTMALT 192
           H++ + S   ++++G+  YG+LGH +  D +VP  V+         +QI  G   + A++
Sbjct: 332 HSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIYAGATCSFAVS 391

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--------HTLAFT 348
             G L+ WG            A + S     +P   K  Q  CGW+         ++   
Sbjct: 392 EMGGLFFWG------------ATNTSRDSTMYP---KAVQDLCGWKVRSLACGKSSIIVA 436

Query: 349 EKKNVFAWGRG-TSGQLGHGEIVDRNTPVIIDALSPDG 459
             ++  +WG   T G+LG+G+   +++    +  + DG
Sbjct: 437 ADESTISWGPSPTFGELGYGDNKAKSSTTAQEVKTLDG 474



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 19/50 (38%), Positives = 31/50 (62%)
 Frame = +1

Query: 298 QKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
           + VA  +C   H+L  T +  +++WGR   GQLGHG+I   + P +I++L
Sbjct: 142 RSVASGSCA-AHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESL 190

---

>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 46/129 (35%), Positives = 77/129 (59%), Gaps = 1/129 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H++ +++ G L+++G ++ GQLGHGD +    P  +EAL   +    + G  HT+ALT  
Sbjct: 159 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDT 218

Query: 199 GKLYGWGWNKFGQVGAGDNADHC-SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G ++ +G NK GQ+G G+  D   SPAQ+ +   Q + ++ACG   ++    K N++++G
Sbjct: 219 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMY-NGQPITKMACGAEFSMLMDCKGNLYSFG 277

Query: 376 RGTSGQLGH 402
               GQLGH
Sbjct: 278 CPEYGQLGH 286



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 53/187 (28%), Positives = 86/187 (45%), Gaps = 25/187 (13%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST-SQISGGWRHTMALTS 195
           HT+ ++ +GS++ +G +K GQLG G+  D  VP   + + +    ++++ G   +M +  
Sbjct: 211 HTLALTDTGSVFAFGENKMGQLGLGNQTD-AVPSPAQIMYNGQPITKMACGAEFSMLMDC 269

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQK----------- 303
            G LY +G  ++GQ+G   +    + AQ               F E+ K           
Sbjct: 270 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 329

Query: 304 VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLES 483
           V  VACG  HTL    +K VF+WG G  G+LGH E  D   P ++      G G  ++ +
Sbjct: 330 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYA 389

Query: 484 SAAIPFA 504
                FA
Sbjct: 390 GYTCSFA 396



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 2/103 (1%)
 Frame = +1

Query: 115 PHKVEALKDSSTSQISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 288
           PH+   L       +  G    H++ +T++GKL+ WG N+ GQ+G GD     +P  +  
Sbjct: 137 PHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEA 196

Query: 289 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
              + +   ACG  HTLA T+  +VFA+G    GQLG G   D
Sbjct: 197 LSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTD 239



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/158 (24%), Positives = 72/158 (45%), Gaps = 11/158 (6%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK--DSSTSQISGGWRHTMALT 192
           HT+ + S   ++++G+  YG+LGH + +D +VP  V+         +QI  G+  + A++
Sbjct: 339 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTCSFAVS 398

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--------HTLAFT 348
             G L+ WG            A + S     +P   K  Q  CGWR         ++   
Sbjct: 399 EVGGLFFWG------------ATNTSRESTMYP---KAVQDLCGWRIRSLACGKSSIIVA 443

Query: 349 EKKNVFAWGRG-TSGQLGHGEIVDRNTPVIIDALSPDG 459
             ++  +WG   T G+LG+G+   +++    +  + DG
Sbjct: 444 ADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDG 481



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 17/40 (42%), Positives = 25/40 (62%)
 Frame = +1

Query: 331 HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 450
           H+L  T +  +++WGR   GQLGHG+      P +I+ALS
Sbjct: 159 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALS 198

---

>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 45/129 (34%), Positives = 75/129 (58%), Gaps = 1/129 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H++ +++ G L+++G ++ GQLGHGD +    P  +E L        + G  HT+ALT  
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220

Query: 199 GKLYGWGWNKFGQVGAGDNADHC-SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G ++ +G NK GQ+G G+  D   SPAQ+ +   Q + ++ACG   ++    K N++++G
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMY-NGQPITKMACGAEFSMIMDCKGNLYSFG 279

Query: 376 RGTSGQLGH 402
               GQLGH
Sbjct: 280 CPEYGQLGH 288



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 53/187 (28%), Positives = 86/187 (45%), Gaps = 25/187 (13%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST-SQISGGWRHTMALTS 195
           HT+ ++ +GS++ +G +K GQLG G+  D  VP   + + +    ++++ G   +M +  
Sbjct: 213 HTLALTETGSVFAFGENKMGQLGLGNQTD-AVPSPAQIMYNGQPITKMACGAEFSMIMDC 271

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQK----------- 303
            G LY +G  ++GQ+G   +    + AQ               F E+ K           
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331

Query: 304 VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLES 483
           V  VACG  HTL    +K VF+WG G  G+LGH E  D   P ++      G G  ++ +
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA 391

Query: 484 SAAIPFA 504
                FA
Sbjct: 392 GYTCSFA 398



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 37/103 (35%), Positives = 53/103 (51%), Gaps = 2/103 (1%)
 Frame = +1

Query: 115 PHKVEALKDSSTSQISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 288
           PH+   L       +  G    H++ +T++GKL+ WG N+ GQ+G GD     +P  +  
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198

Query: 289 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
              + +   ACG  HTLA TE  +VFA+G    GQLG G   D
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTD 241



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 40/158 (25%), Positives = 72/158 (45%), Gaps = 11/158 (6%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK--DSSTSQISGGWRHTMALT 192
           HT+ + S   ++++G+  YG+LGH + +D +VP  V+         SQI  G+  + A++
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--------HTLAFT 348
             G L+ WG            A + S     +P   K  Q  CGWR         ++   
Sbjct: 401 EVGGLFFWG------------ATNTSRESTMYP---KAVQDLCGWRIRSLACGKSSIIVA 445

Query: 349 EKKNVFAWGRG-TSGQLGHGEIVDRNTPVIIDALSPDG 459
             ++  +WG   T G+LG+G+   +++    +  + DG
Sbjct: 446 ADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDG 483



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 16/40 (40%), Positives = 24/40 (60%)
 Frame = +1

Query: 331 HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 450
           H+L  T +  +++WGR   GQLGHG+      P +I+ LS
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 200

---

>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 52/140 (37%), Positives = 77/140 (55%), Gaps = 3/140 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTS 195
           T  +S  G +Y +G S Y QLG    E   +P  + + K+S+ S +  SGG  HT+ + S
Sbjct: 252 TFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDS 311

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           +GK Y  G  ++G++G G+ A+  S P  ++      V+ VACG     A T+   VFAW
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS--RLPAVSSVACGASVGYAVTKDGRVFAW 369

Query: 373 GRGTSGQLGHGEIVDRNTPV 432
           G GT+ QLG G+  D  +PV
Sbjct: 370 GMGTNYQLGTGQDEDAWSPV 389



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 35/116 (30%), Positives = 61/116 (52%), Gaps = 3/116 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           HT+ + S G  Y+ G ++YG+LG G+  E+  +P  +  L   + S ++ G     A+T 
Sbjct: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVTK 362

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVAQVACGWRHTLAFTEKK 357
           DG+++ WG     Q+G G + D  SP ++     E + V  V+ G +HT+   + K
Sbjct: 363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDK 418



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/131 (29%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKD--SSTSQISGGWRHTMALT 192
           H    +  G + T G    GQLG G+   +++  K  AL        Q   G  HT+ L+
Sbjct: 27  HRSHSTEPGLVLTLGQGDVGQLGLGE---NVMERKKPALVSIPEDVVQAEAGGMHTVCLS 83

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
             G++Y +G N  G +G   + +           ++KV QV+ G  HT A T+   VF W
Sbjct: 84  KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLW 143

Query: 373 G--RGTSGQLG 399
           G  R  +G +G
Sbjct: 144 GSFRDNNGVIG 154



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSK--YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGW 171
           V A   HT  ++  G ++ +G  +   G +G  +  +  +VP +V+   D    +++ G 
Sbjct: 124 VSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGN 181

Query: 172 RHTMALTSDGKLYGWGWNKFGQVG 243
            H + LT+DG LY  G  + GQ+G
Sbjct: 182 DHLVMLTADGDLYTLGCGEQGQLG 205

---

>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 46/129 (35%), Positives = 75/129 (58%), Gaps = 1/129 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H++ +++ G L+++G +  GQLGHGD +    P  +E L +      + G  HT+ALT +
Sbjct: 134 HSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTEN 193

Query: 199 GKLYGWGWNKFGQVGAGDNADH-CSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G +Y +G NK GQ+G G+  D   SPA + +   Q + +VACG   ++    K N++++G
Sbjct: 194 GTVYTFGENKLGQLGQGNQTDAVLSPATIQY-NGQPIVKVACGAEFSMIVDCKGNLYSFG 252

Query: 376 RGTSGQLGH 402
               GQLGH
Sbjct: 253 CPEYGQLGH 261



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 52/186 (27%), Positives = 82/186 (44%), Gaps = 24/186 (12%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           HT+ ++ +G++YT+G +K GQLG G+  D ++             +++ G   +M +   
Sbjct: 186 HTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACGAEFSMIVDCK 245

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQKVAQ--------- 312
           G LY +G  ++GQ+G   +    + AQ               F E+ K  Q         
Sbjct: 246 GNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPVPNVVA 305

Query: 313 --VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESS 486
             VACG  HTL    +K VF+WG G  G+LGH E  D   P ++      G G  ++   
Sbjct: 306 RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCG 365

Query: 487 AAIPFA 504
               FA
Sbjct: 366 YQCSFA 371



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 38/103 (36%), Positives = 53/103 (51%), Gaps = 2/103 (1%)
 Frame = +1

Query: 115 PHKVEALKDSSTSQISGG--WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 288
           PH+   L D   S +  G    H++ +T++GKL+ WG N  GQ+G GD     +P  +  
Sbjct: 112 PHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEG 171

Query: 289 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
             E+ +   ACG  HTLA TE   V+ +G    GQLG G   D
Sbjct: 172 LGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTD 214



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 40/145 (27%), Positives = 69/145 (47%), Gaps = 27/145 (18%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHG------------DFEDHLVPHKV----EALKDSST- 150
           ++ V   G+LY++G  +YGQLGH             +F+  L+P +V    E  KD    
Sbjct: 239 SMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVL 298

Query: 151 -------SQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV---NFPEEQ 300
                    ++ G  HT+ L S  +++ WG+  +G++G  +  D   P  V   +FP  +
Sbjct: 299 PVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPG-R 357

Query: 301 KVAQVACGWRHTLAFTEKKNVFAWG 375
              Q+ CG++ + A +E   +F WG
Sbjct: 358 GATQIYCGYQCSFALSEMGGLFFWG 382



 Score = 38.1 bits (87), Expect = 0.021
 Identities = 15/42 (35%), Positives = 24/42 (57%)
 Frame = +1

Query: 331 HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 456
           H+L  T +  +++WGR   GQLGHG+      P +I+ L  +
Sbjct: 134 HSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEE 175

---

>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 52/148 (35%), Positives = 75/148 (50%), Gaps = 7/148 (4%)
 Frame = +1

Query: 19  HTITVSSSGSLYTY-----GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTM 183
           H   V+    LYT+     G   +GQLGHGD   +  P  VE L+  +  Q+S G   T+
Sbjct: 380 HFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTV 439

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNA--DHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 357
            +T +G+LY +G + +G +G    A  +   P Q+NF     V QV+CG  H +  T  K
Sbjct: 440 CVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK 499

Query: 358 NVFAWGRGTSGQLGHGEIVDRNTPVIID 441
            V++WG G  G+LG     D  TP  +D
Sbjct: 500 EVYSWGCGEYGRLGLDSEEDYYTPQKVD 527



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 2/128 (1%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFE--DHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           T+ V+  G LY +G   YG +G       + L P ++     +   Q+S G  H + LT 
Sbjct: 438 TVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTR 497

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           + ++Y WG  ++G++G     D+ +P +V+ P+   +  V CG   T   T+   V A G
Sbjct: 498 NKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACG 557

Query: 376 RGTSGQLG 399
                +LG
Sbjct: 558 LNEFNKLG 565



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 41/147 (27%), Positives = 64/147 (43%), Gaps = 13/147 (8%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H + ++ +  +Y++G  +YG+LG    ED+  P KV+  K      +  G   T  LT  
Sbjct: 491 HVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQS 550

Query: 199 GKLYGWGWNKFGQVGAGD--------NADHCSPAQVNFPEEQ-----KVAQVACGWRHTL 339
           GK+   G N+F ++G            A H  P   +F   +     K+  +A G  HT 
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610

Query: 340 AFTEKKNVFAWGRGTSGQLGHGEIVDR 420
           A  E+  +  +G    GQLG G    R
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKR 637



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/139 (28%), Positives = 65/139 (46%), Gaps = 14/139 (10%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------------QIS 162
           T  ++ SG +   G +++ +LG       ++ H+       +TS              I+
Sbjct: 544 TFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIA 603

Query: 163 GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK-VAQVACGWRHTL 339
            G  HT A+   G+L  +G NK GQ+G G+         +  P   K V +V+CG   T+
Sbjct: 604 PGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTI 663

Query: 340 AFTEKKNVFAWGRGTSGQL 396
           A T+  ++FAWG G +G+L
Sbjct: 664 AATDDNHIFAWGNGGNGRL 682



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 49/206 (23%), Positives = 78/206 (37%), Gaps = 7/206 (3%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
            HT  +   G L T+G +K GQLG G+++  L  + +   L      ++S G   T+A T 
Sbjct: 608  HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATD 667

Query: 196  DGKLYGWGWNKFGQVG-AGDNADHCSPAQVNFPEE-----QKVAQVACGWRHTLAFTEKK 357
            D  ++ WG    G++        H S    ++P         V  ++C   HT+   EK 
Sbjct: 668  DNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKV 727

Query: 358  NVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFAAKIWVSPSERY 537
                  R  S  L  G +   ++P              + ES    P         ++R 
Sbjct: 728  LNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRG 787

Query: 538  ALVPDEKVAKPGDATARGNGADASVP 615
                 E +  P +A    NGA +S P
Sbjct: 788  M----EGLISPTEAMGNSNGASSSCP 809



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 23/96 (23%), Positives = 40/96 (41%), Gaps = 9/96 (9%)
 Frame = +1

Query: 310 QVACGWRHTLAFTEKKNVFAW-----GRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKK 474
           QV  G  H    T +K ++ W     G    GQLGHG+      P  ++ L   G    +
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKL--QGKAIHQ 430

Query: 475 L----ESSAAIPFAAKIWVSPSERYALVPDEKVAKP 570
           +    + +  +    +++   S+ Y  +  +KVA P
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGP 466

---

>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 51/148 (34%), Positives = 74/148 (50%), Gaps = 7/148 (4%)
 Frame = +1

Query: 19  HTITVSSSGSLYTY-----GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTM 183
           H   V+    LYT+     G   +GQLGHGD   +  P  VE L+  +  Q+S G   T+
Sbjct: 380 HFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTV 439

Query: 184 ALTSDGKLYGWGWNKFGQVGAG--DNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 357
            +T +G+LY +G + +G +G       +   P Q+NF     V QV+CG  H +  T  K
Sbjct: 440 CVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK 499

Query: 358 NVFAWGRGTSGQLGHGEIVDRNTPVIID 441
            V++WG G  G+LG     D  TP  +D
Sbjct: 500 EVYSWGCGEYGRLGLDSEEDYYTPQRVD 527



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 2/128 (1%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFE--DHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           T+ V+  G LY +G   YG +G       + L P ++     +   Q+S G  H + LT 
Sbjct: 438 TVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTR 497

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           + ++Y WG  ++G++G     D+ +P +V+ P+   +  V CG   T   T+   V A G
Sbjct: 498 NKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACG 557

Query: 376 RGTSGQLG 399
                +LG
Sbjct: 558 LNEFNKLG 565



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 40/147 (27%), Positives = 64/147 (43%), Gaps = 13/147 (8%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H + ++ +  +Y++G  +YG+LG    ED+  P +V+  K      +  G   T  LT  
Sbjct: 491 HVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQS 550

Query: 199 GKLYGWGWNKFGQVGAGD--------NADHCSPAQVNFPEEQ-----KVAQVACGWRHTL 339
           GK+   G N+F ++G            A H  P   +F   +     K+  +A G  HT 
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610

Query: 340 AFTEKKNVFAWGRGTSGQLGHGEIVDR 420
           A  E+  +  +G    GQLG G    R
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKR 637



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/139 (28%), Positives = 65/139 (46%), Gaps = 14/139 (10%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------------QIS 162
           T  ++ SG +   G +++ +LG       ++ H+       +TS              I+
Sbjct: 544 TFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIA 603

Query: 163 GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK-VAQVACGWRHTL 339
            G  HT A+   G+L  +G NK GQ+G G+         +  P   K V +V+CG   T+
Sbjct: 604 PGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTI 663

Query: 340 AFTEKKNVFAWGRGTSGQL 396
           A T+  ++FAWG G +G+L
Sbjct: 664 AATDDNHIFAWGNGGNGRL 682



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 7/144 (4%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
            HT  +   G L T+G +K GQLG G+++  L  + +   L      ++S G   T+A T 
Sbjct: 608  HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATD 667

Query: 196  DGKLYGWGWNKFGQVG-AGDNADHCSPAQVNFPEE-----QKVAQVACGWRHTLAFTEKK 357
            D  ++ WG    G++        H S    ++P         V  ++C   HT+   EK 
Sbjct: 668  DNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKV 727

Query: 358  NVFAWGRGTSGQLGHGEIVDRNTP 429
                  R  S  L  G +V  ++P
Sbjct: 728  LNSKTIRSNSSGLSIGTVVQSSSP 751



 Score = 29.3 bits (64), Expect = 10.0
 Identities = 16/51 (31%), Positives = 22/51 (43%), Gaps = 5/51 (9%)
 Frame = +1

Query: 310 QVACGWRHTLAFTEKKNVFAW-----GRGTSGQLGHGEIVDRNTPVIIDAL 447
           QV  G  H    T +K ++ W     G    GQLGHG+      P  ++ L
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKL 423

---

>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 50/134 (37%), Positives = 75/134 (55%), Gaps = 7/134 (5%)
 Frame = +1

Query: 19  HTITVSSSGSLYTY----GWSK-YGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTM 183
           H   V+    LYT+    G SK +GQLGHGD   +  P  VE L+  S  ++S G   T+
Sbjct: 362 HFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTV 421

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNA--DHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 357
            +T +G+LY +G + +G +G   +A  +   P  V+F   + V QV+CG  H +A T  K
Sbjct: 422 CITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSK 481

Query: 358 NVFAWGRGTSGQLG 399
           +V++WG G  G+LG
Sbjct: 482 SVYSWGCGEYGRLG 495



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 38/128 (29%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDF--EDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           T+ ++  G LY++G   YG LG       + L P  V+   +    Q+S G  H MALT 
Sbjct: 420 TVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTR 479

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
              +Y WG  ++G++G     D  SP +V       +  V CG   +   T    V A G
Sbjct: 480 SKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLACG 539

Query: 376 RGTSGQLG 399
                +LG
Sbjct: 540 LNEHNKLG 547



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 14/133 (10%)
 Frame = +1

Query: 40  SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------------QISGGWRHT 180
           +G +   G +++ +LG   +   ++ H+       +TS              IS G  HT
Sbjct: 532 TGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHT 591

Query: 181 MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRHTLAFTEKK 357
            A+   G+L  +G NK GQ+G GD   H     +  P   ++V +V+CG   T A T   
Sbjct: 592 AAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATADN 651

Query: 358 NVFAWGRGTSGQL 396
           ++FAWG G +G+L
Sbjct: 652 HIFAWGNGGNGRL 664



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 13/143 (9%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H + ++ S S+Y++G  +YG+LG    +D   P KVE  +      +  G   +  LT  
Sbjct: 473 HIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLT 532

Query: 199 GKLYGWGWNKFGQVGAGDNA----DHCSPAQVNFPEE---------QKVAQVACGWRHTL 339
           GK+   G N+  ++G         +H +  +V +             K+  ++ G  HT 
Sbjct: 533 GKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTA 592

Query: 340 AFTEKKNVFAWGRGTSGQLGHGE 408
           A  E+  +  +G    GQLG G+
Sbjct: 593 AIDERGRLLTFGSNKCGQLGVGD 615



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 36/120 (30%), Positives = 55/120 (45%), Gaps = 8/120 (6%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTS 195
           HT  +   G L T+G +K GQLG GD+  HL  + +   L      ++S G   T A T+
Sbjct: 590 HTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATA 649

Query: 196 DGKLYGWGWNKFGQVGAGDN-----ADHCS--PAQVNFPEEQKVAQVACGWRHTLAFTEK 354
           D  ++ WG    G++    N     +D C+  P  + F     V  ++C   HT+   EK
Sbjct: 650 DNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPI-FGSLHHVTDLSCRGWHTILIVEK 708



 Score = 29.6 bits (65), Expect = 7.6
 Identities = 16/54 (29%), Positives = 23/54 (42%), Gaps = 5/54 (9%)
 Frame = +1

Query: 301 KVAQVACGWRHTLAFTEKKNVFAW-----GRGTSGQLGHGEIVDRNTPVIIDAL 447
           +  QV  G  H    T +K ++ W     G    GQLGHG+      P  ++ L
Sbjct: 352 RARQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKL 405

---

>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 52/138 (37%), Positives = 75/138 (54%), Gaps = 2/138 (1%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTS 195
           T  VS  G +Y +G S Y QLG  + +    P  + + K+S+ S I  SGG  HT+ + S
Sbjct: 257 TFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVCVDS 316

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           +GK Y  G  ++G++G G+NA+  S      P+  K+  VA G   + A +    VFAWG
Sbjct: 317 EGKAYSLGRAEYGRLGLGENAEEQS-EPTPIPDLPKINSVASGASVSYAVSTDGCVFAWG 375

Query: 376 RGTSGQLGHGEIVDRNTP 429
            GT+ QLG GE  D  +P
Sbjct: 376 MGTNLQLGTGEEEDVWSP 393



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 3/117 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           HT+ V S G  Y+ G ++YG+LG G+  E+   P  +  L     + ++ G   + A+++
Sbjct: 310 HTVCVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDL--PKINSVASGASVSYAVST 367

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVAQVACGWRHTLAFTEKKN 360
           DG ++ WG     Q+G G+  D  SP Q+     E+++V  V+ G +HT+    K++
Sbjct: 368 DGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQHTVLLVRKRS 424



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 43/132 (32%), Positives = 66/132 (50%), Gaps = 5/132 (3%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFED--HLVPHKVEALKDSSTSQISGGWRHTMALT 192
           HT+ + +SGS+YT+G +  G LG    E+   + P KVE  +     Q+S G  HT ALT
Sbjct: 84  HTVCLGASGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAE--KVVQVSAGDSHTAALT 141

Query: 193 SDGKLYGWG--WNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNV 363
            DG+++ +G   +  G +G  +       P QV       V ++A G  H +  T   ++
Sbjct: 142 EDGRVFVFGSFRDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVLLTVDGDL 199

Query: 364 FAWGRGTSGQLG 399
           +  G G  GQLG
Sbjct: 200 YTSGCGEQGQLG 211

---

>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 50/140 (35%), Positives = 76/140 (54%), Gaps = 3/140 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTS 195
           T  +S  G +Y +G S Y QLG        +P  + + K+S+ S +  SGG  HT+ + S
Sbjct: 252 TFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTICMDS 311

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           +GK Y  G  ++G++G G+ A+  S P  ++      V+ VACG     A ++   VFAW
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS--RLPVVSSVACGASVGYAVSKDGRVFAW 369

Query: 373 GRGTSGQLGHGEIVDRNTPV 432
           G GT+ QLG G+  D  +PV
Sbjct: 370 GMGTNYQLGTGQDEDAWSPV 389



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 41/130 (31%), Positives = 58/130 (44%), Gaps = 3/130 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFE-DHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           H    +  G + T G    GQLG G+   +   P  V  L+D    Q   G  HT+ L  
Sbjct: 27  HRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLLQD--VVQAEAGGMHTVCLNQ 84

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
            G++Y +G N  G +G   + +           ++KV QV+ G  HT A TE   VF WG
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWG 144

Query: 376 --RGTSGQLG 399
             R  +G +G
Sbjct: 145 SFRDNNGVIG 154



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 35/116 (30%), Positives = 60/116 (51%), Gaps = 3/116 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           HTI + S G  Y+ G ++YG+LG G+  E+  +P  +  L     S ++ G     A++ 
Sbjct: 305 HTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--VVSSVACGASVGYAVSK 362

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRHTLAFTEKK 357
           DG+++ WG     Q+G G + D  SP ++     E + V  V+ G +HT+   + K
Sbjct: 363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDK 418



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSK--YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGW 171
           V A   HT  ++  G ++ +G  +   G +G  +  +  +VP +V+   D    +++ G 
Sbjct: 124 VSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DMPVVKVASGN 181

Query: 172 RHTMALTSDGKLYGWGWNKFGQVG 243
            H + LT+DG LY  G  + GQ+G
Sbjct: 182 DHLVMLTTDGDLYTLGCGEQGQLG 205

---

>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 50/140 (35%), Positives = 76/140 (54%), Gaps = 3/140 (2%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTS 195
           T  +S  G +Y +G S Y QLG        +P  + + K+S+ S +  SGG  HT+ + S
Sbjct: 252 TFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDS 311

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           +GK Y  G  ++G++G G+ A+  S P  ++      V+ VACG     A ++   VFAW
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS--RLPVVSSVACGASVGYAVSKDGRVFAW 369

Query: 373 GRGTSGQLGHGEIVDRNTPV 432
           G GT+ QLG G+  D  +PV
Sbjct: 370 GMGTNYQLGTGQDEDAWSPV 389



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 40/122 (32%), Positives = 57/122 (46%), Gaps = 3/122 (2%)
 Frame = +1

Query: 43  GSLYTYGWSKYGQLGHGDFE-DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 219
           G + T G    GQLG G+   +   P  V  L+D    Q   G  HT+ L+  G++Y +G
Sbjct: 35  GLVLTLGQGDVGQLGLGESVLERKKPALVPLLQD--VVQAEAGGMHTVCLSQSGQVYSFG 92

Query: 220 WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG--RGTSGQ 393
            N  G +G   + +           ++KV QV+ G  HT A TE   VF WG  R  +G 
Sbjct: 93  CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGV 152

Query: 394 LG 399
           +G
Sbjct: 153 IG 154



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 33/110 (30%), Positives = 58/110 (52%), Gaps = 3/110 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 195
           HT+ + S G  Y+ G ++YG+LG G+  E+  +P  +  L     S ++ G     A++ 
Sbjct: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--VVSSVACGASVGYAVSK 362

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRHTL 339
           DG+++ WG     Q+G G + D  SP ++     E + V  V+ G +HT+
Sbjct: 363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTV 412



 Score = 33.1 bits (74), Expect = 0.69
 Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSK--YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGW 171
           V A   HT  ++  G ++ +G  +   G +G  +  +  +VP +V+   D+   +++ G 
Sbjct: 124 VSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DAPVVKVASGN 181

Query: 172 RHTMALTSDGKLYGWGWNKFGQVG 243
            H + LT+DG LY  G  + GQ+G
Sbjct: 182 DHLVMLTNDGDLYTLGCGEQGQLG 205

---

>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 42/128 (32%), Positives = 70/128 (54%), Gaps = 1/128 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST-SQISGGWRHTMALTS 195
           HT+  + +G +Y  G +  GQLG GD +D    H++     + T  Q+S G   + ALT 
Sbjct: 98  HTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTE 157

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           DGKL+ WG N  GQ+G  D ++ C P +V     + ++ ++CG+ H+   T    ++ +G
Sbjct: 158 DGKLFMWGDNSEGQIGLEDKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYTFG 215

Query: 376 RGTSGQLG 399
              +G+LG
Sbjct: 216 EPENGKLG 223



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 43/128 (33%), Positives = 63/128 (49%), Gaps = 1/128 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           HT  V+ +  LY +G + +GQLG G     + P  ++ALK       + G  HT+  T  
Sbjct: 46  HTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDT 105

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQ-VNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G +Y  G N  GQ+G GD  D  +  Q V F     + Q++ G   + A TE   +F WG
Sbjct: 106 GGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWG 165

Query: 376 RGTSGQLG 399
             + GQ+G
Sbjct: 166 DNSEGQIG 173



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 44/132 (33%), Positives = 67/132 (50%)
 Frame = +1

Query: 31  VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 210
           V  +G+++T+G +K+ +          +P K    K+     +S G  HT  +T + KLY
Sbjct: 8   VPDTGAVFTFGKTKFAEN---------IPSKFW-FKNDIPICLSCGDEHTAIVTGNNKLY 57

Query: 211 GWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSG 390
            +G N +GQ+G G  A    P  +   + +KV   ACG  HTL  T+   V+A G    G
Sbjct: 58  MFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEG 117

Query: 391 QLGHGEIVDRNT 426
           QLG G+  DR+T
Sbjct: 118 QLGLGDTDDRDT 129



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 42/138 (30%), Positives = 72/138 (52%), Gaps = 3/138 (2%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWR 174
           +   + H+  V+  G LYT+G  + G+LG  +    +H  P +V  + +    Q++ G  
Sbjct: 195 ISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPER-VIQVACGGG 253

Query: 175 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
           HT+ LT +  +Y +G  +FGQ+G G      S P  +   ++QK+  ++CG  HT   TE
Sbjct: 254 HTVVLT-EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTE 312

Query: 352 KKNVFAWGRGTSGQLGHG 405
              ++ +G G  G+LG G
Sbjct: 313 LGLLYTFGDGRHGKLGLG 330



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 16/48 (33%), Positives = 22/48 (45%)
 Frame = +1

Query: 313 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 456
           ++CG  HT   T    ++ +G    GQLG G       P  I AL P+
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPE 87

---

>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 43/128 (33%), Positives = 66/128 (51%), Gaps = 1/128 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           HT  V+ +  LY +G + +GQLG G       P  V+ALK       + G  HT+  T  
Sbjct: 46  HTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEG 105

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVN-FPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           GK+Y  G N  GQ+G GD  +  +   ++ F  ++K+ Q++ G   + A TE   +F WG
Sbjct: 106 GKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWG 165

Query: 376 RGTSGQLG 399
             + GQ+G
Sbjct: 166 DNSEGQIG 173



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 40/128 (31%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDS-STSQISGGWRHTMALTS 195
           HT+  +  G +Y  G +  GQLG GD E+    H +          Q+S G   + ALT 
Sbjct: 98  HTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTE 157

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           DG+L+ WG N  GQ+G  +  + C P QV     + ++ ++CG+ H+   T +  ++ +G
Sbjct: 158 DGELFMWGDNSEGQIGLENVTNVCVPQQVTV--GKPISWISCGYYHSAFVTTEGQLYTFG 215

Query: 376 RGTSGQLG 399
               G+LG
Sbjct: 216 EPECGKLG 223



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 44/129 (34%), Positives = 66/129 (51%)
 Frame = +1

Query: 40  SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 219
           SG+++T+G +++ +          +P K     D  T  +S G  HT  +T + KLY +G
Sbjct: 11  SGAVFTFGKTQFAEN---------IPSKFWFRNDVPTF-LSCGDEHTAVVTGNNKLYMFG 60

Query: 220 WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
            N +GQ+G G  +    P  V   + +KV   ACG  HTL  TE   V+A G    GQLG
Sbjct: 61  SNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLG 120

Query: 400 HGEIVDRNT 426
            G+  +R+T
Sbjct: 121 LGDTEERST 129



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 42/138 (30%), Positives = 72/138 (52%), Gaps = 3/138 (2%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWR 174
           +   + H+  V++ G LYT+G  + G+LG  +    +H +P  V  +      Q++ G  
Sbjct: 195 ISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIP-GKVVQVACGGG 253

Query: 175 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
           HT+ LT    +Y +G  +FGQ+G G      S P  +   ++QK++ +ACG  HT   T+
Sbjct: 254 HTVVLTEKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITD 312

Query: 352 KKNVFAWGRGTSGQLGHG 405
              ++ +G G  G+LG G
Sbjct: 313 MGLMYTFGDGRHGKLGLG 330



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 15/48 (31%), Positives = 23/48 (47%)
 Frame = +1

Query: 313 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 456
           ++CG  HT   T    ++ +G    GQLG G     + P  + AL P+
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPE 87

---

>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 46/129 (35%), Positives = 66/129 (51%)
 Frame = +1

Query: 40  SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 219
           SG+++T+G SK+ +   G F            K+     +S G  H+  +T + KLY +G
Sbjct: 11  SGAVFTFGKSKFAENNPGKFW----------FKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60

Query: 220 WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
            N +GQ+G G  +    P  V   + +KV   ACG  HTL  TE  NV+A G    GQLG
Sbjct: 61  SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120

Query: 400 HGEIVDRNT 426
            G+  +RNT
Sbjct: 121 LGDTEERNT 129



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 41/128 (32%), Positives = 68/128 (53%), Gaps = 1/128 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEAL-KDSSTSQISGGWRHTMALTS 195
           HT+  +  G++Y  G +  GQLG GD E+    H +     +    Q+S G   + ALT 
Sbjct: 98  HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157

Query: 196 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           DG+L+ WG N  GQ+G  + ++ C P QV     + V+ ++CG+ H+   T    ++ +G
Sbjct: 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFG 215

Query: 376 RGTSGQLG 399
              +G+LG
Sbjct: 216 EPENGKLG 223



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 42/128 (32%), Positives = 64/128 (50%), Gaps = 1/128 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H+  V+ +  LY +G + +GQLG G       P  V+ALK       + G  HT+  T  
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVN-FPEEQKVAQVACGWRHTLAFTEKKNVFAWG 375
           G +Y  G N  GQ+G GD  +  +   ++ F  E K+ Q++ G   + A TE   +F WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165

Query: 376 RGTSGQLG 399
             + GQ+G
Sbjct: 166 DNSEGQIG 173



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 39/138 (28%), Positives = 70/138 (50%), Gaps = 3/138 (2%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWR 174
           +   + H+  V++ G LY +G  + G+LG  +    +H  P  V  + +    Q++ G  
Sbjct: 195 ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGGE 253

Query: 175 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
           HT+ LT +  +Y +G  +FGQ+G G      S P  +    +Q ++ ++CG  HT   T+
Sbjct: 254 HTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312

Query: 352 KKNVFAWGRGTSGQLGHG 405
              ++ +G G  G+LG G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 21/90 (23%), Positives = 39/90 (43%)
 Frame = +1

Query: 187 LTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 366
           +   G ++ +G +KF +          +P +  F  +  V  ++CG  H+   T    ++
Sbjct: 8   MPDSGAVFTFGKSKFAEN---------NPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLY 57

Query: 367 AWGRGTSGQLGHGEIVDRNTPVIIDALSPD 456
            +G    GQLG G     + P  + AL P+
Sbjct: 58  MFGSNNWGQLGLGSKSAISKPTCVKALKPE 87

---

>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 53/159 (33%), Positives = 74/159 (46%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H+  V+  G L+  G +K GQLG G  E+ L     + L+     Q++ GW  T+ LT  
Sbjct: 60  HSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEK 119

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGR 378
           G++   G N FGQ+G       C   Q      +KV  VA G RH LA T   +VF WG 
Sbjct: 120 GQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGT 179

Query: 379 GTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAI 495
           G +   G      +N P+ + A  P       LE+S A+
Sbjct: 180 GLASS-GRRLCPGQNLPLFLTAKEPS--RVTGLENSTAV 215



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 47/134 (35%), Positives = 68/134 (50%), Gaps = 8/134 (5%)
 Frame = +1

Query: 28  TVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGK 204
           TVS++  L+ +G + YGQLG G  ED  +P ++ +  +      ++GG  H+  +T  G 
Sbjct: 10  TVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGD 69

Query: 205 LYGWGWNKFGQVGAGDNAD-----HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFA 369
           L+  G NK GQ+G G   +      C P +        + QVACGW  T+  TEK  V +
Sbjct: 70  LFVCGLNKDGQLGLGHTEEVLRFTICKPLR-----GCPIRQVACGWDFTIMLTEKGQVLS 124

Query: 370 WGRGTSGQLG--HG 405
            G    GQLG  HG
Sbjct: 125 CGSNAFGQLGVPHG 138



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 46/141 (32%), Positives = 70/141 (49%), Gaps = 8/141 (5%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGW---SKYGQLGHGD----FEDHLVPHKVEALKDSSTSQI 159
           V A  RH +  +++GS++ +G    S   +L  G     F     P +V  L++S+    
Sbjct: 158 VAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCA 217

Query: 160 SGGWRHTMALTSDGKLYGWGWNKFGQVGA-GDNADHCSPAQVNFPEEQKVAQVACGWRHT 336
             G  H+ +LT  G+LY WG NK GQ+ +           + ++ +++KV  V  GW H 
Sbjct: 218 VAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHL 277

Query: 337 LAFTEKKNVFAWGRGTSGQLG 399
           +A TE   VF WGR   GQLG
Sbjct: 278 VAKTETGKVFTWGRADYGQLG 298



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 46/168 (27%), Positives = 71/168 (42%), Gaps = 23/168 (13%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA--LKDSSTSQISGGWRHTMALT 192
           H+ +++ +G LY +G +K+GQL        L P ++EA   +D   + +  GW H +A T
Sbjct: 223 HSASLTDTGELYVWGRNKHGQLASRAVFLPL-PQRIEAHYFQDEKVTAVWSGWTHLVAKT 281

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK---------------------VA 309
             GK++ WG   +GQ+G         P +   P EQ                        
Sbjct: 282 ETGKVFTWGRADYGQLGR-----RLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTGAT 336

Query: 310 QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSP 453
           +++CG  H LA    K   +WG    G  G G   +  TP  + AL P
Sbjct: 337 EISCGSEHNLAVIRDK-CCSWGWNEHGMCGDGTESNVWTPTPVQALPP 383



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHG------------------DFEDHLVPHKV 126
           V + W H +  + +G ++T+G + YGQLG                        + VP  +
Sbjct: 270 VWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPL 329

Query: 127 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF--PEEQ 300
             L  +  ++IS G  H +A+  D K   WGWN+ G  G G  ++  +P  V    P   
Sbjct: 330 HCL--TGATEISCGSEHNLAVIRD-KCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPS 386

Query: 301 KVAQVACGWRHTLA 342
           ++  V CG  H+LA
Sbjct: 387 RLLLVGCGAGHSLA 400

---

>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 48/128 (37%), Positives = 71/128 (55%), Gaps = 5/128 (3%)
 Frame = +1

Query: 37  SSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGKLYG 213
           ++ +L+ +G + YGQLG G  ED L+P ++ +  K  S  +I+GG  H+  +T  G L+ 
Sbjct: 13  AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72

Query: 214 WGWNKFGQVGAGDNAD--HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTS 387
            G NK GQ+G G   D  + +P +  F     + QVACGW  T+  TE   V + G  + 
Sbjct: 73  CGLNKDGQLGLGHTEDIPYFTPCKSLF--GCPIQQVACGWDFTIMLTENGQVLSCGSNSF 130

Query: 388 GQLG--HG 405
           GQLG  HG
Sbjct: 131 GQLGVPHG 138



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 55/194 (28%), Positives = 85/194 (43%), Gaps = 10/194 (5%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H+  V+  G L+  G +K GQLG G  ED       ++L      Q++ GW  T+ LT +
Sbjct: 60  HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGR 378
           G++   G N FGQ+G       C   Q     ++KV  +A G RH +A T    VF WG 
Sbjct: 120 GQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGT 179

Query: 379 GTSGQLGHGEIVDRNTPVIIDALSPD---GPGCKKL-------ESSAAIPFAAKIWVSPS 528
           G +   G      +  P+   A  P    G    K        + SA++  A +++V  S
Sbjct: 180 GLA-SCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238

Query: 529 ERYALVPDEKVAKP 570
            ++  + +E    P
Sbjct: 239 NKHGQLANEAAFLP 252



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 44/142 (30%), Positives = 69/142 (48%), Gaps = 9/142 (6%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYG---QLGHGD----FEDHLVPHKVEALKDSSTSQI 159
           + A  RH +  ++SG ++ +G        +L  G     F     P +V  L++S    +
Sbjct: 158 IAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCV 217

Query: 160 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRH 333
             G  H+ +LT  G++Y WG NK GQ+ A + A    P ++     + +KV  +  GW H
Sbjct: 218 LAGSDHSASLTDAGEVYVWGSNKHGQL-ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTH 276

Query: 334 TLAFTEKKNVFAWGRGTSGQLG 399
            +A TE   +F WGR   GQLG
Sbjct: 277 LVAQTETGKMFTWGRADYGQLG 298



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 16/133 (12%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHG---------DFEDHLVP--HKVEALKDS- 144
           + + W H +  + +G ++T+G + YGQLG           + +D  +P      ++  S 
Sbjct: 270 IWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSP 329

Query: 145 ----STSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ 312
                 +++S G  H +A+   G  Y WGWN+ G  G G  A+  +P  V          
Sbjct: 330 HCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLL 388

Query: 313 VACGWRHTLAFTE 351
           V CG  H+LA  +
Sbjct: 389 VGCGAGHSLALCQ 401

---

>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 42/126 (33%), Positives = 61/126 (48%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           T  ++  G + T+G    G LGHG+  D   P  VEAL      Q++ G  H +AL++DG
Sbjct: 409 TACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDG 468

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +L+ WG    G++G G    H  P QV     Q+  +V CG   ++  T    V A G  
Sbjct: 469 ELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSN 528

Query: 382 TSGQLG 399
              +LG
Sbjct: 529 RFNKLG 534



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLG--HGDFEDHLVPHKV--EALKDSSTSQ----------I 159
           ++ ++S G +   G +++ +LG  H   ++  VP++   EAL  +              +
Sbjct: 513 SMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCV 572

Query: 160 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTL 339
             G  H+ A+T+ G  Y +G N+ GQ+G        +P +V   E  K+  VACG   T+
Sbjct: 573 DLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTV 632

Query: 340 AFTEKKNVFAWGRGTSGQLG-HGEIVDRNTPVIIDALSP 453
           A   +  V++WG+GT G+LG   E      PV +D   P
Sbjct: 633 AVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHP 671



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 31/108 (28%), Positives = 57/108 (52%), Gaps = 1/108 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H+  +++SG  YT+G +++GQLG         P +V+ L+      ++ G   T+A+ ++
Sbjct: 578 HSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAE 637

Query: 199 GKLYGWGWNKFGQVGAGD-NADHCSPAQVNFPEEQKVAQVACGWRHTL 339
           G++Y WG    G++G  D +A    P Q++      V  V+C   +TL
Sbjct: 638 GEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSCCHGNTL 685



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 34/110 (30%), Positives = 48/110 (43%)
 Frame = +1

Query: 100 EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 279
           +   V   +E     +   ++ G   T  LT  G +  +G    G +G G+  D   P  
Sbjct: 383 QPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTI 442

Query: 280 VNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
           V      ++ QVACG  H LA +    +FAWGRG  G+LG G     N P
Sbjct: 443 VEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCP 492



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 18/145 (12%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H + +S+ G L+ +G    G+LG G  E H  P +V         ++  G   +M LTS 
Sbjct: 460 HVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSP 519

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFP------------------EEQKVAQVACG 324
           G++   G N+F ++G     DH S  +   P                  +++ +  V  G
Sbjct: 520 GRVLACGSNRFNKLG----LDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLG 575

Query: 325 WRHTLAFTEKKNVFAWGRGTSGQLG 399
             H+ A T   + + +G    GQLG
Sbjct: 576 TAHSAAITASGDCYTFGSNQHGQLG 600



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
 Frame = +1

Query: 154 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ------- 312
           Q++ G      +T  G+L  W   +   +GAG       P  V  P+ Q V++       
Sbjct: 342 QVAAGRTQKAGVTRSGRLILW---EAPPLGAGGGT--LLPGAVELPQPQFVSRFLEGQSG 396

Query: 313 -----VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
                VACG   T   T++  +  +G G++G LGHG + D + P I++AL
Sbjct: 397 VTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEAL 446

---

>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 39/136 (28%), Positives = 66/136 (48%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           T  ++  G + T+G    G LGHG+F D   P  VEAL      Q+S G  H +A+T++ 
Sbjct: 410 TTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNER 469

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +++ WG    G++G      H  P QV+ P + +  +V CG   ++  + +  + A G  
Sbjct: 470 EVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNN 529

Query: 382 TSGQLGHGEIVDRNTP 429
              +LG  ++     P
Sbjct: 530 RFNKLGLDKVSGTEEP 545



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 40/142 (28%), Positives = 62/142 (43%), Gaps = 9/142 (6%)
 Frame = +1

Query: 31  VSSSGSLYTYGWSKYGQLGHGD---------FEDHLVPHKVEALKDSSTSQISGGWRHTM 183
           V+ SG L T+   +   +G G+          +   +   +E     +   +S G   T 
Sbjct: 355 VTKSGRLITW---EAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTT 411

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNV 363
            LT  G +  +G    G +G G+  D   P  V      ++ QV+CG  H LA T ++ V
Sbjct: 412 CLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREV 471

Query: 364 FAWGRGTSGQLGHGEIVDRNTP 429
           F+WGRG +G+LG       N P
Sbjct: 472 FSWGRGDNGRLGLATQDSHNCP 493



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 28/81 (34%), Positives = 42/81 (51%)
 Frame = +1

Query: 166 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 345
           G  H++A+T  G+ + +G N+ GQ+G         P QV+    Q +   ACG   TLA 
Sbjct: 576 GTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVS--GLQGITMAACGDAFTLAI 633

Query: 346 TEKKNVFAWGRGTSGQLGHGE 408
             +  V+ WG+G  G+LG  E
Sbjct: 634 GAEGEVYTWGKGARGRLGRKE 654



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H++ V+  G  +T+G +++GQLG        VP++V  L+    +  + G   T+A+ ++
Sbjct: 579 HSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQ--GITMAACGDAFTLAIGAE 636

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ--KVAQVACGWRHTL 339
           G++Y WG    G++G  +  D   P  V   E     V  VAC   +TL
Sbjct: 637 GEVYTWGKGARGRLGRKEE-DFGIPKPVQLDESHAFTVTSVACCHGNTL 684



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/141 (22%), Positives = 61/141 (43%), Gaps = 14/141 (9%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H + V++   ++++G    G+LG    + H  P +V    D    ++  G   +M +++ 
Sbjct: 461 HVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQ 520

Query: 199 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEE--------------QKVAQVACGWRHT 336
            ++   G N+F ++G    +    P+     EE              +K+  +  G  H+
Sbjct: 521 HQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHS 580

Query: 337 LAFTEKKNVFAWGRGTSGQLG 399
           +A TEK   F +G    GQLG
Sbjct: 581 VAVTEKGQCFTFGSNQHGQLG 601



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 32/107 (29%), Positives = 51/107 (47%), Gaps = 9/107 (8%)
 Frame = +1

Query: 154 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA-----DHCSPAQVN-FPEEQK---V 306
           Q+S G    M +T  G+L  W   +   VG+G+       +   P  ++ F E Q    +
Sbjct: 344 QVSLGRTQKMGVTKSGRLITW---EAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTI 400

Query: 307 AQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
             V+CG   T   T++  +  +G G++G LGHG   D   P I++AL
Sbjct: 401 KSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEAL 447

---

>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 2/122 (1%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHG--DFEDHLVPHKVEALKDSSTSQISGGWRHTMALT 192
            H+  + S GSL+T+GW  +GQLGHG  +  + LVP +V  L     +QI+ G  HT+ LT
Sbjct: 838  HSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGL-ICKVTQIACGRAHTVVLT 896

Query: 193  SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
              G++   G   +GQ+G  D+               +V  +A  + H++  TE   VF W
Sbjct: 897  DTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEW 956

Query: 373  GR 378
            GR
Sbjct: 957  GR 958



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 45/129 (34%), Positives = 71/129 (55%), Gaps = 2/129 (1%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
            H + +SSSG L  +G +++GQ G G        H+V+     +  +I+ G  H+  + SD
Sbjct: 787  HILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDG-DWPAIEKIACGQFHSAFICSD 845

Query: 199  GKLYGWGWNKFGQVGAG--DNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
            G L+ +GW  +GQ+G G  +N++   P +VN     KV Q+ACG  HT+  T+   V   
Sbjct: 846  GSLWTFGWGVWGQLGHGGRNNSNQLVPTRVN-GLICKVTQIACGRAHTVVLTDTGRVLVC 904

Query: 373  GRGTSGQLG 399
            G G+ GQ+G
Sbjct: 905  GSGSYGQMG 913



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 5/86 (5%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
            H+  ++S G+LYT+G     QLGHG+  + + PH+V     +    +S G  HT+A T D
Sbjct: 1033 HSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDD 1092

Query: 199  GKLYGWGWNKFGQVGA-----GDNAD 261
            G ++ WG N FGQ G      G++AD
Sbjct: 1093 GSVFAWGKNDFGQCGVLTKKNGNSAD 1118



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 33/93 (35%), Positives = 49/93 (52%)
 Frame = +1

Query: 121  KVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ 300
            +V+   D +   ++ G  H+  +TS+G LY WG     Q+G G+  +   P QV  P   
Sbjct: 1015 EVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGA 1074

Query: 301  KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
            K   V+ G  HT+A T+  +VFAWG+   GQ G
Sbjct: 1075 KWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCG 1107



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 40/175 (22%), Positives = 65/175 (37%), Gaps = 38/175 (21%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
            HT+ ++ +G +   G   YGQ+G  D    +       L       I+  + H++ +T D
Sbjct: 891  HTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITED 950

Query: 199  GKLYGWGWN------------KFGQVGAGDNADHCSPA----------QVNFPEE----- 297
             +++ WG N            K       +  D  SP+           +N P E     
Sbjct: 951  NRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPRED 1010

Query: 298  -----------QKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
                         +  VACG  H+   T +  ++ WG+G   QLGHG   +R  P
Sbjct: 1011 LGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEP 1065



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 29/83 (34%), Positives = 46/83 (55%)
 Frame = +1

Query: 157  ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT 336
            I+ G  H + L+S G+L  WG N+FGQ G G +    +  QV+  +   + ++ACG  H+
Sbjct: 781  IACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVD-GDWPAIEKIACGQFHS 839

Query: 337  LAFTEKKNVFAWGRGTSGQLGHG 405
                   +++ +G G  GQLGHG
Sbjct: 840  AFICSDGSLWTFGWGVWGQLGHG 862

---

>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 40/126 (31%), Positives = 59/126 (46%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           T  ++  G + T+G    G LGHG   D   P  VEAL      Q++ G  H +AL+++ 
Sbjct: 403 TACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTER 462

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +L+ WG    G++G G    H  P QV  P  Q+  +V CG   ++  T      A G  
Sbjct: 463 ELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSN 522

Query: 382 TSGQLG 399
              +LG
Sbjct: 523 RFNKLG 528



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 46/152 (30%), Positives = 68/152 (44%), Gaps = 15/152 (9%)
 Frame = +1

Query: 43  GSLYTYGWSKYGQLG--HGDFEDHLVPHKV--EALK----------DSSTSQISGGWRHT 180
           G     G +++ +LG  H    +  VPH+   EAL                 I  G  H+
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHS 573

Query: 181 MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 360
            A+T+ G  Y +G N+ GQ+G        +P +V   E  K+A VACG   T+A   +  
Sbjct: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633

Query: 361 VFAWGRGTSGQLG-HGEIVDRNTPVIIDALSP 453
           V++WG+G  G+LG   E      PV +D   P
Sbjct: 634 VYSWGKGARGRLGRRDEDAGLPRPVQLDETHP 665



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 1/108 (0%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
           H+  V++SG  YT+G +++GQLG         P KV+ L+    + ++ G   T+A+ ++
Sbjct: 572 HSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAE 631

Query: 199 GKLYGWGWNKFGQVGAGD-NADHCSPAQVNFPEEQKVAQVACGWRHTL 339
            ++Y WG    G++G  D +A    P Q++      V  V+C   +TL
Sbjct: 632 SEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTL 679



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 31/84 (36%), Positives = 42/84 (50%)
 Frame = +1

Query: 178 TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 357
           T  LT  G +  +G    G +G G   D   P  V      ++ QVACG  H LA + ++
Sbjct: 403 TACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTER 462

Query: 358 NVFAWGRGTSGQLGHGEIVDRNTP 429
            +FAWGRG SG+LG G     + P
Sbjct: 463 ELFAWGRGDSGRLGLGTRESHSCP 486



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 12/110 (10%)
 Frame = +1

Query: 154 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ------- 312
           Q++ G      +T  G+L  W   +   +GAG  +    P  V  P+ Q +++       
Sbjct: 336 QVAAGRTQKAGVTRSGRLILW---EAPPLGAGGGS--LLPGAVEQPQPQFISRFLEGQSG 390

Query: 313 -----VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
                VACG   T   T++  +  +G G++G LGHG + D + P I++AL
Sbjct: 391 VTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEAL 440

---

>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 44/147 (29%), Positives = 68/147 (46%), Gaps = 17/147 (11%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHG--DFEDHLV---PHKVEALKDSSTSQISGGWRHTM 183
           H+  + + G +Y +G +   Q G    D E+  V   P  V+AL+  +   I+GG  HT+
Sbjct: 290 HSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTL 349

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNA------------DHCSPAQVNFPEEQKVAQVACGW 327
           AL  DG++  WG +   Q+G  DNA            ++        P    V QV CG 
Sbjct: 350 ALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVCGT 409

Query: 328 RHTLAFTEKKNVFAWGRGTSGQLGHGE 408
            H LA T    V++WG   + ++G G+
Sbjct: 410 HHNLAVTSDGKVYSWGSAENYEVGQGD 436



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 49/175 (28%), Positives = 76/175 (43%), Gaps = 17/175 (9%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLG---------HGDFEDHLV----PHKVE-ALKDSSTSQ 156
           H+  +S  G +YT+G +    LG         +GD  D+ +    P KVE AL     ++
Sbjct: 119 HSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTK 178

Query: 157 ISGGWRHTMALTSDGKLYGWGWNKF--GQVGAGDNADHCS-PAQVNFPEEQKVAQVACGW 327
           +      T A+T +G  + WG  +   G +G  D+    + P Q+  PE   + Q+A G 
Sbjct: 179 VICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPE---ICQLATGT 235

Query: 328 RHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAA 492
            H +A T    V+ WG G   QLG   +  R     +  L+P     K + S  A
Sbjct: 236 DHIIALTTTGKVYTWGNGQQFQLGRRMLERRR----LQGLTPQPLALKNIISVGA 286



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 17/96 (17%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKD-----------------SS 147
           HT+ +   G +  +G     QLG     D+ +P  V  +KD                 ++
Sbjct: 347 HTLALLEDGRVLAWGRDDRHQLG---IPDNALPETV--VKDEKGNNYYLSTPTIIPGLTN 401

Query: 148 TSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN 255
             Q+  G  H +A+TSDGK+Y WG  +  +VG GDN
Sbjct: 402 VIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDN 437



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 38/141 (26%), Positives = 61/141 (43%), Gaps = 20/141 (14%)
 Frame = +1

Query: 46  SLYTYGWSKYGQLGHGDFEDHLV--PHKVEALKDSSTS--QISGGWRHTMALTSDGKLYG 213
           ++Y +G     +LG G+ E  +V  P     L         ++ G  H+ AL+ DG++Y 
Sbjct: 72  NVYVFGSGSMNELGMGEEEMDVVYRPRLNPILSTDKVGVVDLAVGGMHSAALSHDGRVYT 131

Query: 214 WGWNKFGQVGA---------GDNADH----CSPAQVNFP-EEQKVAQVACGWRHTLAFTE 351
           WG N    +G          GD  D+     +P++V       +V +V C    T A T+
Sbjct: 132 WGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITD 191

Query: 352 KKNVFAWG--RGTSGQLGHGE 408
               F WG  R + G LG+ +
Sbjct: 192 NGCCFTWGTFRCSDGVLGYSD 212

---

>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 35/97 (36%), Positives = 53/97 (54%)
 Frame = +1

Query: 109  LVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 288
            L P  ++    S   Q++ G  HT+ LT  G++Y +G N++GQ+G+GD      P +V  
Sbjct: 955  LAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV 1014

Query: 289  PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
            P    ++QVA G  HT+  T K  V+ +G    GQLG
Sbjct: 1015 P--GAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 29/75 (38%), Positives = 48/75 (64%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
            HT+ ++ +G +YT+G ++YGQLG GD +    P +V+     + SQ++ G  HT+ LTS 
Sbjct: 977  HTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV--PGAISQVAAGSNHTVLLTSK 1034

Query: 199  GKLYGWGWNKFGQVG 243
            G +Y +G  + GQ+G
Sbjct: 1035 GMVYTFGNYQKGQLG 1049



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 19/55 (34%), Positives = 27/55 (49%)
 Frame = +1

Query: 268  SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPV 432
            +P  +       V QVACG  HT+  T    V+ +G    GQLG G++   + PV
Sbjct: 956  APQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPV 1010



 Score = 29.3 bits (64), Expect = 10.0
 Identities = 13/29 (44%), Positives = 19/29 (65%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLG 87
            V A   HT+ ++S G +YT+G  + GQLG
Sbjct: 1021 VAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049

---

>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 30/81 (37%), Positives = 48/81 (59%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            V   + H++ +  +G +YT+G+ ++GQLGHGD      P  V+AL   ST Q++ G  HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSNHT 965

Query: 181  MALTSDGKLYGWGWNKFGQVG 243
              L  DG+++ +G    GQ+G
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 23/59 (38%), Positives = 35/59 (59%)
 Frame = +1

Query: 271  PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
            P  V F  E +  QV+CG+ H++   E  +V+ +G G  GQLGHG++  R  P ++ AL
Sbjct: 893  PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQAL 951



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
 Frame = +1

Query: 154  QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGD-NADHCSPAQVNFPEEQKVAQVACGWR 330
            Q+S G+ H++ L  +G +Y +G+ + GQ+G GD N+  C       P      QV  G  
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS--TQVTAGSN 963

Query: 331  HTLAFTEKKNVFAWGRGTSGQLG 399
            HT        VF +G  + GQLG
Sbjct: 964  HTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 28/131 (21%), Positives = 52/131 (39%), Gaps = 4/131 (3%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDH----LVPHKVEALKDSSTSQISGGWRHTMA 186
           H + V+  GS++  G +  G+ G             P K+  ++       +     +  
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 187 LTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 366
           ++ DG+LY +G +        D++   +  + +F     V QVA G  HT    +   V+
Sbjct: 615 ISKDGELYMFGKDAI----YSDSSSLVTDLKGHF-----VTQVAMGKAHTCVLMKNGEVW 665

Query: 367 AWGRGTSGQLG 399
            +G    GQ G
Sbjct: 666 TFGVNNKGQCG 676

---

>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 37/109 (33%), Positives = 52/109 (47%)
 Frame = +1

Query: 139  DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVA 318
            D   S +S G  HT+ L SD +++ +G N  GQ+G GD     +P QV  P +  + QVA
Sbjct: 766  DVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVA 825

Query: 319  CGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPG 465
             G  HT+      +VF +G    GQL            I + +S  GPG
Sbjct: 826  AGSNHTILRANDGSVFTFGAFGKGQLARPAGEKAGWNAIPEKVSGFGPG 874



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 26/82 (31%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
 Frame = +1

Query: 19   HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 198
            HT+ ++S   ++T+G + +GQLG GD      P +V    D+   Q++ G  HT+   +D
Sbjct: 778  HTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAGSNHTILRAND 837

Query: 199  GKLYGWGWNKFGQVG--AGDNA 258
            G ++ +G    GQ+   AG+ A
Sbjct: 838  GSVFTFGAFGKGQLARPAGEKA 859



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/47 (40%), Positives = 28/47 (59%)
 Frame = +1

Query: 289 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
           P + KV+ V+CG  HT+     + VF +G    GQLG G+ + +NTP
Sbjct: 764 PHDVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTP 810

---

>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 41/151 (27%), Positives = 66/151 (43%), Gaps = 18/151 (11%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLG----HGDFEDHLV---PHKVEALKDSSTSQISGGWRH 177
           H   +  S ++Y +G ++YGQ      +G+ ED  V   P  +  L      +I+ G  H
Sbjct: 262 HCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEIAAGEHH 321

Query: 178 TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEE-----------QKVAQVACG 324
           T+ALT DG++Y WG     ++G   +    S  ++N                K+  +  G
Sbjct: 322 TLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLFAVKIKTIGVG 381

Query: 325 WRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
             H+ A TE   V+AWG   +   G G  +D
Sbjct: 382 SHHSFAVTEDGVVYAWGFAETYGPGLGPSID 412



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 7/88 (7%)
 Frame = +1

Query: 157 ISGGWRHTMALTSDGKLYGWGWNKFGQVG-AGDNAD------HCSPAQVNFPEEQKVAQV 315
           I+ G  H  A+     +Y WG N++GQ    GDN +         P  +     + + ++
Sbjct: 256 IASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEI 315

Query: 316 ACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
           A G  HTLA TE   V+AWGR    ++G
Sbjct: 316 AAGEHHTLALTEDGQVYAWGRYDMKEIG 343



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 35/143 (24%), Positives = 53/143 (37%), Gaps = 31/143 (21%)
 Frame = +1

Query: 127 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF------------------GQVGAGD 252
           E L  +     + G  HT+AL    +++ WG N                    G+ G  D
Sbjct: 60  EKLGGTKIVDFAVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDD 119

Query: 253 NAD---------HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG--RGTSGQLG 399
           + D           +PA V    E ++ Q+A     + A     +V++WG  R   G LG
Sbjct: 120 DDDDEDGDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLG 179

Query: 400 --HGEIVDRNTPVIIDALSPDGP 462
               EI  + TP+ I  L    P
Sbjct: 180 FLRDEIKLQKTPLKIKELKKHCP 202



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 8/73 (10%)
 Frame = +1

Query: 205 LYGWGWNKFGQVGAGDNADHCSPAQVNF----PEEQ----KVAQVACGWRHTLAFTEKKN 360
           ++ WG     ++G G +A +    +        EE+    K+   A G  HTLA   K  
Sbjct: 26  VFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNR 85

Query: 361 VFAWGRGTSGQLG 399
           +++WG   S  LG
Sbjct: 86  IWSWGGNDSEVLG 98



 Score = 29.3 bits (64), Expect = 10.0
 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 7/59 (11%)
 Frame = +1

Query: 304 VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG----HGEIVDRNT---PVIIDALSPDG 459
           +  +A G  H  A     NV+AWG    GQ      +GE+ D +    P +I  LS  G
Sbjct: 253 IKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKG 311

---

>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 44/144 (30%), Positives = 70/144 (48%), Gaps = 2/144 (1%)
 Frame = +1

Query: 34  SSSGSLYTYGWSKYGQLGHGDF--EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKL 207
           S +  ++  G + + QL H     E  L P K E LKD     I+GG  HT+ LT+D K 
Sbjct: 258 SQTQVIWATGLNNFKQLAHETKGKEFALTPIKTE-LKD--IRHIAGGQHHTVILTTDLKC 314

Query: 208 YGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTS 387
              G  ++G++G GD  D      +     +K+  V CG   + A T    +++WG G +
Sbjct: 315 SVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVN 374

Query: 388 GQLGHGEIVDRNTPVIIDALSPDG 459
            QLG G+  D   P+++ + +  G
Sbjct: 375 NQLGVGDGDDELEPIVVVSKNTQG 398



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 34/133 (25%), Positives = 51/133 (38%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           + A   H + ++ SG +Y++G +  G LG    ED                 IS G  H+
Sbjct: 79  ISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHS 138

Query: 181 MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 360
             L  DG+++ WG  +      G   D      ++  E      +A G  H +  T    
Sbjct: 139 ACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGK 198

Query: 361 VFAWGRGTSGQLG 399
           VF  G    GQLG
Sbjct: 199 VFTVGCAEQGQLG 211



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 43/152 (28%), Positives = 63/152 (41%), Gaps = 3/152 (1%)
 Frame = +1

Query: 43  GSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-QISGGWRHTMALTSDGKLYGWG 219
           G++   G    GQLG G  ED L   ++  +     +  IS G  H + LT  G +Y +G
Sbjct: 42  GNVLVCGNGDVGQLGLG--EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFG 99

Query: 220 WNKFGQVGAGDNAD--HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQ 393
            N  G +G   + D     P  ++ P   K   ++ G  H+    E   VFAWG      
Sbjct: 100 CNDEGALGRDTSEDGSESKPDLIDLPG--KALCISAGDSHSACLLEDGRVFAWGSFRDSH 157

Query: 394 LGHGEIVDRNTPVIIDALSPDGPGCKKLESSA 489
              G  +D N    ID +  +G  C  + S A
Sbjct: 158 GNMGLTIDGNKRTPIDLM--EGTVCCSIASGA 187



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRH--TMALT 192
           HT+ +++       G  +YG+LG GD +D  V  K   +K  +   +S G     + A+T
Sbjct: 304 HTVILTTDLKCSVVGRPEYGRLGLGDVKD--VVEKPTIVKKLTEKIVSVGCGEVCSYAVT 361

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQV 282
            DGKLY WG     Q+G GD  D   P  V
Sbjct: 362 IDGKLYSWGSGVNNQLGVGDGDDELEPIVV 391



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 20/60 (33%), Positives = 28/60 (46%), Gaps = 2/60 (3%)
 Frame = +1

Query: 31  VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTSDGK 204
           V+  G LY++G     QLG GD +D L P  V +        +  SGG +H + L    K
Sbjct: 360 VTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADK 419

---

>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 35/104 (33%), Positives = 51/104 (49%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 228
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 229 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 360
           FGQ+G  D      P       E  V  VA G  ++L   + ++
Sbjct: 588 FGQLGHSD-FPTTVPRLAKISSENGVWSVAAGRDYSLFLVDTED 630



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 26/69 (37%), Positives = 38/69 (55%)
 Frame = +1

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +++ WG  K GQ+G GD      P  V   + ++V  +  G  H+LA T K  V++WG  
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 382 TSGQLGHGE 408
           T GQLGH +
Sbjct: 587 TFGQLGHSD 595



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/136 (27%), Positives = 61/136 (44%), Gaps = 8/136 (5%)
 Frame = +1

Query: 16  RHTITVSSSGSLYTYGWSKYGQLGHGDFED-HLVPHKVEALKDSSTSQISGGWRHTMALT 192
           +H + ++  G +Y++G   +     G  E     P    AL       ++ G  H+ A+T
Sbjct: 51  KHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVVTVATGSFHSGAVT 107

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ-------KVAQVACGWRHTLAFTE 351
            +G  Y WG N  GQ    +      P  V+  + +       ++ Q+ACG  HTLA + 
Sbjct: 108 DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSI 167

Query: 352 KKNVFAWGRGTSGQLG 399
            + ++AWG G   QLG
Sbjct: 168 SREIWAWGTGC--QLG 181



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 9/120 (7%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS--------QISGGWR 174
           H+  V+ +G  Y +G +  GQ    + +    P+ V ++ DS  S        Q++ G  
Sbjct: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPV-SIADSEASPLLAVRILQLACGEE 160

Query: 175 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
           HT+AL+   ++  W W    Q+G    A   + P +V     + V QVACG  H+LA  +
Sbjct: 161 HTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 17/44 (38%), Positives = 26/44 (59%)
 Frame = +1

Query: 352 KKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLES 483
           +  V+ WG+G  GQLGHG+++ R  P+ +  L  DG     LE+
Sbjct: 525 RTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL--DGKEVIHLEA 566



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 14/57 (24%), Positives = 32/57 (56%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 189
           H++ +++   +Y++G + +GQLGH DF    VP   +   ++    ++ G  +++ L
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSVAAGRDYSLFL 625

---

>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 34/104 (32%), Positives = 51/104 (49%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 228
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 229 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 360
           FGQ+G  D      P       E  V  +A G  ++L   + ++
Sbjct: 588 FGQLGHSD-FPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 26/69 (37%), Positives = 38/69 (55%)
 Frame = +1

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +++ WG  K GQ+G GD      P  V   + ++V  +  G  H+LA T K  V++WG  
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 382 TSGQLGHGE 408
           T GQLGH +
Sbjct: 587 TFGQLGHSD 595



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/136 (27%), Positives = 61/136 (44%), Gaps = 8/136 (5%)
 Frame = +1

Query: 16  RHTITVSSSGSLYTYGWSKYGQLGHGDFED-HLVPHKVEALKDSSTSQISGGWRHTMALT 192
           +H + ++  G +Y++G   +     G  E     P    AL       ++ G  H+ A+T
Sbjct: 51  KHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSFHSGAVT 107

Query: 193 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ-------KVAQVACGWRHTLAFTE 351
            +G  Y WG N  GQ    +      P  V+  + +       ++ Q+ACG  HTLA + 
Sbjct: 108 DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSI 167

Query: 352 KKNVFAWGRGTSGQLG 399
            + ++AWG G   QLG
Sbjct: 168 SREIWAWGTGC--QLG 181



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 9/120 (7%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS--------QISGGWR 174
           H+  V+ +G  Y +G +  GQ    + +    P+ V ++ DS  S        Q++ G  
Sbjct: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPV-SIADSEASPLLAVRILQLACGEE 160

Query: 175 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTE 351
           HT+AL+   ++  W W    Q+G    A   + P +V     + V QVACG  H+LA  +
Sbjct: 161 HTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 17/44 (38%), Positives = 26/44 (59%)
 Frame = +1

Query: 352 KKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLES 483
           +  V+ WG+G  GQLGHG+++ R  P+ +  L  DG     LE+
Sbjct: 525 RTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL--DGKEVIHLEA 566



 Score = 34.3 bits (77), Expect = 0.31
 Identities = 15/57 (26%), Positives = 32/57 (56%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 189
           H++ +++   +Y++G + +GQLGH DF    VP   +   ++    I+ G  +++ L
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFL 625

---

>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 39/120 (32%), Positives = 57/120 (47%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 228
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 522 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNT 581

Query: 229 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 408
           FGQ+G  +      P       E  V  VA G  ++L   + ++ F  G   SG+    E
Sbjct: 582 FGQLGHSE-FPTTVPRLSKVSSENGVWSVAAGQDYSLFLVDTED-FQPGLYYSGRQDRAE 639



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 27/69 (39%), Positives = 38/69 (55%)
 Frame = +1

Query: 202 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +++ WG  K GQ+G GD      P  V   + ++V  +  G  H+LA T K  V++WG  
Sbjct: 521 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSN 580

Query: 382 TSGQLGHGE 408
           T GQLGH E
Sbjct: 581 TFGQLGHSE 589



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 40/141 (28%), Positives = 66/141 (46%), Gaps = 13/141 (9%)
 Frame = +1

Query: 16  RHTITVSSSGSLYTYG---W-SKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWRH 177
           RH + ++  G +Y++G   W S+  ++       E  LV H V          ++ G  H
Sbjct: 51  RHGVLLTEDGEVYSFGTLPWKSESAEICPSSPLLESALVGHHVIT--------VATGSFH 102

Query: 178 TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ-------KVAQVACGWRHT 336
           + A+T  G +Y WG N  GQ    +      P+ V+  + +       ++ Q+ACG  HT
Sbjct: 103 SGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLAVRILQLACGEEHT 162

Query: 337 LAFTEKKNVFAWGRGTSGQLG 399
           LA +  + ++AWG G   QLG
Sbjct: 163 LALSLSREIWAWGTGC--QLG 181



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 9/120 (7%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS--------QISGGWR 174
           H+  V+ SG +Y +G +  GQ    + +    P  V ++ DS TS        Q++ G  
Sbjct: 102 HSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPV-SISDSETSPSLAVRILQLACGEE 160

Query: 175 HTMALTSDGKLYGWGWN-KFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTE 351
           HT+AL+   +++ WG   + G +          P +V     + V QVACG  H+LA  +
Sbjct: 161 HTLALSLSREIWAWGTGCQLGLITT--TFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 17/47 (36%), Positives = 27/47 (57%)
 Frame = +1

Query: 352 KKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAA 492
           +  V+ WG+G  GQLGHG+++ R  P+ +  L  DG     LE+  +
Sbjct: 519 RTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL--DGKEVIHLEAGGS 563



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 14/63 (22%), Positives = 34/63 (53%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
           + A   H++ +++   +Y++G + +GQLGH +F    VP   +   ++    ++ G  ++
Sbjct: 558 LEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEFPT-TVPRLSKVSSENGVWSVAAGQDYS 616

Query: 181 MAL 189
           + L
Sbjct: 617 LFL 619

---

>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 29/81 (35%), Positives = 47/81 (58%)
 Frame = +1

Query: 1    VHAXWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 180
            V   + H++ +  +G +YT+G+ ++GQLGHGD      P  V+AL   ST Q++    HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTACSNHT 965

Query: 181  MALTSDGKLYGWGWNKFGQVG 243
              L  DG+++ +G    GQ+G
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 23/59 (38%), Positives = 35/59 (59%)
 Frame = +1

Query: 271  PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 447
            P  V F  E +  QV+CG+ H++   E  +V+ +G G  GQLGHG++  R  P ++ AL
Sbjct: 893  PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQAL 951



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 26/82 (31%), Positives = 38/82 (46%)
 Frame = +1

Query: 154  QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRH 333
            Q+S G+ H++ L  +G +Y +G+ + GQ+G GD      P  V           AC   H
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTACS-NH 964

Query: 334  TLAFTEKKNVFAWGRGTSGQLG 399
            T        VF +G  + GQLG
Sbjct: 965  TAVLLMDGQVFTFGSFSKGQLG 986



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 29/131 (22%), Positives = 52/131 (39%), Gaps = 4/131 (3%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDH----LVPHKVEALKDSSTSQISGGWRHTMA 186
           H + V+  GS++  G +  G+ G             P K+  ++       +     +  
Sbjct: 555 HALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 187 LTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 366
           ++ DG+LY +G +        D++   S  + +F     V QVA G  HT    +   V+
Sbjct: 615 ISKDGELYMFGKDAI----YSDSSSLVSDLKGHF-----VTQVAMGKAHTCVLMKNGEVW 665

Query: 367 AWGRGTSGQLG 399
            +G    GQ G
Sbjct: 666 TFGVNNKGQCG 676

---

>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 10/145 (6%)
 Frame = +1

Query: 25  ITVSSSGSLYTYGWSKYGQLGH-GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           + VS+ G L+ +G S+Y QL    D     VP  +         Q + G      L  +G
Sbjct: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEG 355

Query: 202 KLYGWGWNKFGQVGAGDN-ADHCSPAQV--------NFPEEQKVAQVACGWRHTLAFTEK 354
            ++ WG   +G +G G N  +   P  +         F  E +V+++ CG  H  A T K
Sbjct: 356 HVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412

Query: 355 KNVFAWGRGTSGQLGHGEIVDRNTP 429
             +F WG+   G LG G + D+  P
Sbjct: 413 GELFVWGKNIRGCLGIGRLEDQYFP 437



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
 Frame = +1

Query: 136 KDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG--DNADHCSPAQVNFPEE--QK 303
           +++   Q+S G  H++ LT    ++  G N +GQ G    +N  +    +V+  ++   +
Sbjct: 172 QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ 231

Query: 304 VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
           V QVACG  H+L  T+K  V++ G G  GQ G G     ++P
Sbjct: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 13/109 (11%)
 Frame = +1

Query: 112 VPHKVEALKDSSTSQISGGWRHTMALTSD-GKLYGWGWNKFGQVGAGDNADH-------- 264
           VP+++E  +  S++    G+    + T+D  K++G G NK  Q+G   +           
Sbjct: 99  VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158

Query: 265 CSPAQVNFP----EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
             P+ V+ P    +E +V QV+CG  H+L  T+++ VF+ G  + GQ G
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCG 207



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 9/116 (7%)
 Frame = +1

Query: 31  VSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKV--------EALKDSSTSQISGGWRHTM 183
           ++  G ++ +G   YG LG G +  +  VP  +        E   +   S+I  G  H  
Sbjct: 351 LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTE 351
           ALT+ G+L+ WG N  G +G G   D   P +V  P E     VACG  H +   +
Sbjct: 408 ALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP--VDVACGVDHMVTLAK 461

---

>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 10/130 (7%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV------PHKVEALKDSSTSQISGGWRHT 180
           H + +   G ++ +G  +  QLG    E   +      P  +  +K      I+ G  H 
Sbjct: 232 HILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVK-----YIASGENHC 286

Query: 181 MALTSDGKLYGWGWNKFGQVGAGDNADH----CSPAQVNFPEEQKVAQVACGWRHTLAFT 348
            ALT D KL  WG N+FGQ G  ++ +       P ++  P+   +  +A G  H+L  +
Sbjct: 287 FALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILS 346

Query: 349 EKKNVFAWGR 378
           +  ++++ GR
Sbjct: 347 QDGDLYSCGR 356



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 39/149 (26%), Positives = 63/149 (42%), Gaps = 16/149 (10%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKVE--ALKDSSTSQ-ISGGWRHTMA 186
           H   ++    L ++G +++GQ G   D ED  +  K +  AL D+   + I+ G  H++ 
Sbjct: 285 HCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLI 344

Query: 187 LTSDGKLYGWGWNKFGQVG-AGDNADHCS-----------PAQVNFPEEQKVAQVACGWR 330
           L+ DG LY  G     +VG   DN    +           P         K   VA G  
Sbjct: 345 LSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSH 404

Query: 331 HTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
           H++A  +    ++WG G +  +G G   D
Sbjct: 405 HSVAVAQNGIAYSWGFGETYAVGLGPFED 433



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
 Frame = +1

Query: 37  SSGSLYTYGWSKYGQLGHGDFEDHL----VPHKVEALKDSSTSQISGGWRHTMALTSDGK 204
           S+G +Y +G  +  +   G ++D +     P KV      +  Q++ G  H + L  +G 
Sbjct: 182 SNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGM 241

Query: 205 LYGWGWNKFGQVG----AGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 372
           ++ WG  +  Q+G             P        + V  +A G  H  A T+   + +W
Sbjct: 242 VFAWGNGQQNQLGRKVMERFRLKTLDPRPFGL---RHVKYIASGENHCFALTKDNKLVSW 298

Query: 373 GRGTSGQLGHGEIVD 417
           G    GQ G  E V+
Sbjct: 299 GLNQFGQCGVSEDVE 313



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 4/76 (5%)
 Frame = +1

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNADHC----SPAQVNFPEEQKVAQVACGWRHTLAFTE 351
           AL S+G++Y WG  +  +   G   D      +P +V    +  + Q+A G  H L   E
Sbjct: 179 ALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDE 238

Query: 352 KKNVFAWGRGTSGQLG 399
           +  VFAWG G   QLG
Sbjct: 239 EGMVFAWGNGQQNQLG 254



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 27/105 (25%), Positives = 44/105 (41%), Gaps = 11/105 (10%)
 Frame = +1

Query: 118 HKVEALKDSSTSQISGG---WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 288
           H+ + +  +  S I      ++H         ++ WG     ++G G  A +    +V  
Sbjct: 16  HRAKKMSKTHASHIINAQEDYKHMYLSVQPLDIFCWGTGSMCELGLGPLAKN---KEVKR 72

Query: 289 P--------EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 399
           P        +E K+   A G  HTLA  E+ NV++WG    G LG
Sbjct: 73  PRLNPFLPRDEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALG 117

---

>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 39/145 (26%), Positives = 64/145 (44%), Gaps = 10/145 (6%)
 Frame = +1

Query: 25  ITVSSSGSLYTYGWSKYGQLGH-GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 201
           + +S+ G ++ +G S+Y QL    D     VP  +         Q++ G      L ++G
Sbjct: 293 LALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAVLNAEG 352

Query: 202 KLYGWGWNKFGQVGAGDNA-DHCSPAQV--------NFPEEQKVAQVACGWRHTLAFTEK 354
            ++ WG   +G +G G    +   P  +         F  E +V+Q+ CG  H  A T K
Sbjct: 353 HVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTNK 409

Query: 355 KNVFAWGRGTSGQLGHGEIVDRNTP 429
             +F WG+   G LG G + D+  P
Sbjct: 410 GELFVWGKNIRGCLGIGRLEDQYFP 434



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 13/115 (11%)
 Frame = +1

Query: 112 VPHKVEALKDSSTSQISGGWRHTMALTSD-GKLYGWGWNKFGQVGAGDNADHCS------ 270
           VP+++E     S++    G+    + T D  K++G G NK  Q+G   +    +      
Sbjct: 96  VPYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 155

Query: 271 ------PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 417
                 P  ++ P+E KV QV+CG  H+L  T+++ VF+ G  + GQ G   + D
Sbjct: 156 LEPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVED 210



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 33/110 (30%), Positives = 49/110 (44%), Gaps = 4/110 (3%)
 Frame = +1

Query: 112 VPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP 291
           VP  ++  +++   Q+S G  H++ LT    ++  G N  GQ G     D          
Sbjct: 161 VPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVH 220

Query: 292 EEQ----KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
             Q    +V QV CG  H+L  T+K  V++ G G  GQ G G     +TP
Sbjct: 221 RMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTP 270



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 9/116 (7%)
 Frame = +1

Query: 31  VSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKV--------EALKDSSTSQISGGWRHTM 183
           +++ G ++ +G   YG LG G    +  +P  +        E   +   SQI  G  H  
Sbjct: 348 LNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFA 404

Query: 184 ALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTE 351
           ALT+ G+L+ WG N  G +G G   D   P +V  P E     VACG  H +   +
Sbjct: 405 ALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP--VDVACGVDHMVTLAK 458

---

>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 41/147 (27%), Positives = 63/147 (42%), Gaps = 19/147 (12%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLG--------HGDFEDH-----LVPHKVEALKDSSTSQIS 162
           TI     G  Y +G + Y QLG          D +D+      +P +  A     T    
Sbjct: 381 TIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLPAEAPAFGAERTFVNI 440

Query: 163 GGWRHTMALTSDGKLYGWGWNKFGQVGAG-----DNADHCSPAQVNFPE-EQKVAQVACG 324
            G +H + L SDGK++  G N    +G G     D+  H     +   E + K+  V+  
Sbjct: 441 EGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDSKIVGVSAK 500

Query: 325 WRHTLAFTEKKNVFAWGRGTSGQLGHG 405
              ++A++E    +AWG  T+GQLG G
Sbjct: 501 LATSIAWSEDGTAYAWGFDTTGQLGLG 527



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 33/138 (23%), Positives = 57/138 (41%), Gaps = 11/138 (7%)
 Frame = +1

Query: 19  HTITVSSSGSLYTYGWSKYGQLGHGDFEDH-------LVPHKVEALKDSSTSQISGGWRH 177
           H+  ++S G +Y  G ++ G +     E          V  + +  K+     ++ G   
Sbjct: 196 HSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEKEGKIVMLAAGASF 255

Query: 178 TMALTSDGKLYGWG--WNKFGQVGAGD--NADHCSPAQVNFPEEQKVAQVACGWRHTLAF 345
           T ALT  G +  WG   N  G V      +    +P  +    ++K+ ++A G  H +  
Sbjct: 256 TAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKIAAGENHLVML 315

Query: 346 TEKKNVFAWGRGTSGQLG 399
            EK  +  +G G  GQLG
Sbjct: 316 DEKGCLLTFGDGEMGQLG 333



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 42/167 (25%), Positives = 63/167 (37%), Gaps = 32/167 (19%)
 Frame = +1

Query: 1   VHAXWRHTITVSSSGSLYTYGWSKYGQLGHG-------------DFEDHLV-----PHKV 126
           + A   H + +   G L T+G  + GQLG               +  DHL+      HK 
Sbjct: 305 IAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKG 364

Query: 127 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG-DNADHCSPAQVN------ 285
           +     + +  + G+  T+    DGK Y +G N + Q+G   D AD     Q N      
Sbjct: 365 KFFDVVAKNVFASGF-WTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVF 423

Query: 286 -------FPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHG 405
                  F  E+    +  G +H +       VFA G+ T   LG G
Sbjct: 424 LPAEAPAFGAERTFVNIE-GVQHVVILGSDGKVFAMGKNTDNALGLG 469

---

>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 36/115 (31%), Positives = 52/115 (45%), Gaps = 4/115 (3%)
 Frame = +1

Query: 49  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TSQISGGWRHTMALTSDGKLYGWGWN 225
           +Y +G +   QLG G  ED   P +     D +   +I+ G  H++ LT+DG L G G N
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 226 KFGQVGAGD---NADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           + G++ +           P +V  P    V  VACGW  T+       V  W RG
Sbjct: 64  RRGELDSAQALRQVHDWRPVEVPAP----VVDVACGWDTTVIVDADGRV--WQRG 112



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
 Frame = +1

Query: 205 LYGWGWNKFGQVGAGDNADHCSPAQ-VNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 381
           +Y +G N   Q+G G + D  +P + V   +   V ++ACG  H++  T   N+   G  
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 382 TSGQL 396
             G+L
Sbjct: 64  RRGEL 68

---

>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
 Frame = +1

Query: 166 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 345
           G+ H   +   G+++  G N++GQ+G GD  D   P QV++   Q+   + CG  H+L  
Sbjct: 375 GYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHY--LQRPIALWCGLNHSLVL 432

Query: 346 TE----KKNVFAWGRGTSGQL 396
           ++     K +   G G  G+L
Sbjct: 433 SQTSDFSKELLGCGCGAGGRL 453



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/73 (34%), Positives = 33/73 (45%)
 Frame = +1

Query: 229 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 408
           FG + A D  DH  P  ++ P   KV   A G+ H     E   +F  G    GQLG G+
Sbjct: 346 FGTLQAFDPLDHQMPLALSLPA--KVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGD 403

Query: 409 IVDRNTPVIIDAL 447
            +DR  P  +  L
Sbjct: 404 KMDRGEPTQVHYL 416



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 25/83 (30%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
 Frame = +1

Query: 13  WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL- 189
           + H   V   G ++  G ++YGQLG GD  D   P +V  L+      +  G  H++ L 
Sbjct: 376 YNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQ--RPIALWCGLNHSLVLS 433

Query: 190 -TSD-------------GKLYGW 216
            TSD             G+L GW
Sbjct: 434 QTSDFSKELLGCGCGAGGRLPGW 456

---

>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
 Frame = +1

Query: 166 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 345
           G+ H   +   G+++  G N++GQ+G GD  D   P QV +   Q+   + CG  H+L  
Sbjct: 365 GYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCY--LQRPITLWCGLNHSLVL 422

Query: 346 TE----KKNVFAWGRGTSGQL 396
           ++     K +   G G  G+L
Sbjct: 423 SQSSEFSKELLGCGCGAGGRL 443



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 33/114 (28%), Positives = 47/114 (41%), Gaps = 6/114 (5%)
 Frame = +1

Query: 106 HLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY------GWGWNKFGQVGAGDNADHC 267
           H +PH   A   S+ S        T+ +T  G +Y      G   + FG + A D  D  
Sbjct: 296 HYLPHLRVACMTSNQSS-------TLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQ 348

Query: 268 SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
            P  ++ P   K+   A G+ H     E   +F  G    GQLG G+ +DR  P
Sbjct: 349 MPLALSLPA--KILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEP 400



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 5/108 (4%)
 Frame = +1

Query: 13  WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALT 192
           + H   V   G ++  G ++YGQLG GD  D   P +V  L+   T  +  G  H++ L+
Sbjct: 366 YNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQRPIT--LWCGLNHSLVLS 423

Query: 193 SDG----KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ-KVAQVAC 321
                  +L G G       GAG           +F + Q KV   AC
Sbjct: 424 QSSEFSKELLGCG------CGAGGRLPGWPKGSASFVKLQVKVPLCAC 465

---

>S12A2_HUMAN (P55011) Solute carrier family 12 member 2 (Bumetanide-sensitive|
           sodium-(potassium)-chloride cotransporter 1)
           (Basolateral Na-K-Cl symporter)
          Length = 1212

 Score = 33.1 bits (74), Expect = 0.69
 Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 4/86 (4%)
 Frame = -2

Query: 417 VNYFPMTELSTSTPSPCKHIFLFCESKSVPPSTSNLGNFLFLRKIN----LGWGTVISII 250
           VN   +TEL+  T + CK  F F   +S P S   + NF  +  ++    L    + S  
Sbjct: 552 VNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSAT 611

Query: 249 ASSNLPKLVPSPSIKFSI*CKCHCVP 172
            SS L  LV +P I F   CK +  P
Sbjct: 612 LSSALASLVSAPKI-FQALCKDNIYP 636

---

>DAK_BOVIN (Q58DK4) Dihydroxyacetone kinase (EC 2.7.1.29) (Glycerone kinase)|
           (DHA kinase)
          Length = 578

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
 Frame = +1

Query: 430 VIIDALSPDGPGCKKLES---SAAIPFAAKIWVSPSERYALVPDEKVAKPGDATARGNGA 600
           V +  L  D P  K +++   ++A P  AK+WV+  +R    P E +A P   TA G  +
Sbjct: 312 VSLTLLLVDEPLLKLIDAETTASAWPNVAKVWVTGRKRSRAAPTEPLAAPDSTTAAGEAS 371

Query: 601 DASV 612
              V
Sbjct: 372 KQMV 375

---

>PWP2_SCHPO (Q9C1X1) Periodic tryptophan protein 2 homolog|
          Length = 854

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +1

Query: 22  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDS-STSQISGGWRHTMALTSD 198
           T+TV+S+G     G SK GQL   +++      K ++  D+ ST Q S   +  +    D
Sbjct: 301 TLTVNSTGDWIAIGSSKLGQLLVWEWQSESYVLKQQSHYDALSTLQYSSDGQRIITGADD 360

Query: 199 GKLYGWGWN 225
           GK+  W  N
Sbjct: 361 GKIKVWDMN 369

---

>ERG6_NEUCR (Q9P3R1) Sterol 24-C-methyltransferase (EC 2.1.1.41)|
           (Delta(24)-sterol C-methyltransferase)
          Length = 379

 Score = 31.2 bits (69), Expect = 2.6
 Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 8/84 (9%)
 Frame = +1

Query: 97  FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWN-KFGQVGAGDNA----- 258
           F++     + +A +++ T + +   RH   L +D   YGWG    F +   G++      
Sbjct: 55  FDNKTAEAETQADREARTKEYATLTRHYYNLATDIYEYGWGQCFHFCRYSPGESFYQAIA 114

Query: 259 --DHCSPAQVNFPEEQKVAQVACG 324
             +H   AQ+   ++ KV  V CG
Sbjct: 115 RHEHYLAAQIGIKKDMKVLDVGCG 138

---

>MKL2_MOUSE (P59759) MKL/myocardin-like protein 2 (Myocardin-related|
           transcription factor B) (MRTF-B)
          Length = 1080

 Score = 30.8 bits (68), Expect = 3.4
 Identities = 16/37 (43%), Positives = 20/37 (54%)
 Frame = +1

Query: 439 DALSPDGPGCKKLESSAAIPFAAKIWVSPSERYALVP 549
           DALSPD P  ++ + SAA P   K+  SP    A  P
Sbjct: 182 DALSPDQPASQESQGSAASPSEPKVSASPPPVTASTP 218

---

>MKL2_HUMAN (Q9ULH7) MKL/myocardin-like protein 2 (Myocardin-related|
           transcription factor B) (MRTF-B) (Megakaryoblastic
           leukemia 2)
          Length = 1088

 Score = 30.8 bits (68), Expect = 3.4
 Identities = 15/30 (50%), Positives = 19/30 (63%)
 Frame = +1

Query: 439 DALSPDGPGCKKLESSAAIPFAAKIWVSPS 528
           DALSPD P  ++ + SAA P   K+  SPS
Sbjct: 182 DALSPDQPASQESQGSAASPSEPKVSESPS 211

---

>FREM2_LYTVA (Q9GV77) Extracellular matrix protein 3 precursor (FREM2 homolog)|
          Length = 3103

 Score = 30.8 bits (68), Expect = 3.4
 Identities = 15/48 (31%), Positives = 24/48 (50%)
 Frame = +2

Query: 137  RIALHPRFQVDGGTQWHLHQMENFMDGDGTSLGKLELAIMLITVPQPR 280
            R+A    F+VD G  W+LH + +    + + +GK E     I+  Q R
Sbjct: 2955 RLASDALFEVDYGRTWYLHSIYSMRSSESSGIGKRETEHHAISSRQRR 3002

---

>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 19/81 (23%), Positives = 35/81 (43%)
 Frame = +1

Query: 157 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT 336
           +S G  H +A+ +D  +Y W   +  Q    + A+   P++   P    + ++A GW   
Sbjct: 369 VSSGRSHFLAMDTDNNIYSWDSTESDQGVKIEFAN--LPSRATNP----ILKIASGWNFN 422

Query: 337 LAFTEKKNVFAWGRGTSGQLG 399
             +  K  + AW    + Q G
Sbjct: 423 CCYIYKVGLVAWKERDAIQKG 443



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 19/87 (21%)
 Frame = +1

Query: 157 ISGGWRHTMALTSDGKLYGWGWNK--FGQVGAGD-----------------NADHCSPAQ 279
           ++ G  HT+ALT  G LY WG      G +G G                  N     P +
Sbjct: 551 VASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEGQRNIRVVKPTK 610

Query: 280 VNFPEEQKVAQVACGWRHTLAFTEKKN 360
           +  PE+     V  G   T A   KK+
Sbjct: 611 IELPEDYICVSVTAGGWQTGALIIKKH 637

---

>KLPA_EMENI (P28739) Kinesin-like protein klpA|
          Length = 770

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
 Frame = +1

Query: 73  YGQLGHGDFE-----DHLVPHKVEALKDSSTSQISGGWRHTM 183
           YGQ G G        D ++P  V  + +++TS    GWR+TM
Sbjct: 513 YGQTGSGKTHTMSSLDGMIPRAVHQIYETATSLEEKGWRYTM 554

---

>STC2_STAAU (P17855) Staphylocoagulase precursor|
          Length = 715

 Score = 30.0 bits (66), Expect = 5.8
 Identities = 25/97 (25%), Positives = 38/97 (39%), Gaps = 2/97 (2%)
 Frame = +1

Query: 145 STSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF--PEEQKVAQVA 318
           +  Q+S G R T    S+   Y    +  GQV  G    +  P++ N          QV+
Sbjct: 541 ANGQVSYGARPTQKKPSETNAYNVTTHANGQVSYGARPTYNKPSETNAYNVTTHGNGQVS 600

Query: 319 CGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 429
            G R T     K N +      +GQ+ +G    +N P
Sbjct: 601 YGARPTYKKPSKTNAYNVTTHANGQVSYGARPTQNKP 637

---

>MUC_CHICK (P01875) Ig mu chain C region|
          Length = 446

 Score = 30.0 bits (66), Expect = 5.8
 Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
 Frame = -3

Query: 230 NLFHPHP*SFPSDVSAIVCLHPPEIWDVELSFK-ASTLCGTR 108
           ++ +P P   P+ +   V +HPP   D E  F+ AS LC TR
Sbjct: 97  SVMNPGPIPTPNGIPLFVTMHPPSREDFEGPFRNASILCQTR 138

---

>LOXC_ARATH (P38418) Lipoxygenase, chloroplast precursor (EC 1.13.11.12)|
          Length = 896

 Score = 29.6 bits (65), Expect = 7.6
 Identities = 14/45 (31%), Positives = 24/45 (53%)
 Frame = +1

Query: 127 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 261
           +A+K+  T  +   +     +TSD +L GW W++   +G GD  D
Sbjct: 675 DAIKEWVTDYVKHYYPDEELITSDEELQGW-WSEVRNIGHGDKKD 718

---

>SLP1_SCHPO (P78972) WD-repeat-containing protein slp1|
          Length = 488

 Score = 29.3 bits (64), Expect = 10.0
 Identities = 18/53 (33%), Positives = 26/53 (49%)
 Frame = +1

Query: 358 NVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPDGPGCKKLESSAAIPFAAKIW 516
           N+  W   +SG     +I   +T V+  ALSPDG    ++ S+AA     K W
Sbjct: 415 NLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDG----RILSTAASDENLKFW 463


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.314    0.132    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,573,775
Number of Sequences: 219361
Number of extensions: 2194606
Number of successful extensions: 4892
Number of sequences better than 10.0: 61
Number of HSP's better than 10.0 without gapping: 4250
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4667
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5767334219
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)

---