Clone Information

BLAST Search Result

Clone Name	bags10m13
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	139	1e-32
2	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	139	1e-32
3	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	136	6e-32
4	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	135	8e-32
5	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	135	1e-31
6	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	132	7e-31
7	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	132	7e-31
8	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	130	3e-30
9	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	129	1e-29
10	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	129	1e-29
11	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	119	8e-27
12	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	119	1e-26
13	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	118	2e-26
14	RCC2_MOUSE (Q8BK67) Protein RCC2	115	1e-25
15	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	114	3e-25
16	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	112	1e-24
17	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	112	1e-24
18	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	111	2e-24
19	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	110	4e-24
20	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	105	1e-22
21	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	105	1e-22
22	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	105	2e-22
23	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	103	6e-22
24	RCC1_XENLA (P25183) Regulator of chromosome condensation	103	6e-22
25	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	102	1e-21
26	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	101	2e-21
27	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	101	2e-21
28	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	100	4e-21
29	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	100	6e-21
30	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	94	3e-19
31	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	89	1e-17
32	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	87	4e-17
33	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	87	4e-17
34	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	87	6e-17
35	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	76	8e-14
36	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	71	2e-12
37	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	71	3e-12
38	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	71	3e-12
39	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	69	1e-11
40	RCC1_CANAL (P52499) Protein RCC1	64	4e-10
41	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	64	5e-10
42	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	62	1e-09
43	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	62	2e-09
44	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	61	3e-09
45	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	60	6e-09
46	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	47	5e-05
47	FBX24_MOUSE (Q9D417) F-box only protein 24	45	2e-04
48	FBX24_HUMAN (O75426) F-box only protein 24	44	4e-04
49	HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (P...	33	0.73
50	S12A2_HUMAN (P55011) Solute carrier family 12 member 2 (Bumetani...	33	0.73
51	YB9W_YEAST (P38352) F-box protein YBR280C	33	0.73
52	PWP2_SCHPO (Q9C1X1) Periodic tryptophan protein 2 homolog	32	1.3
53	HCN1_HUMAN (O60741) Potassium/sodium hyperpolarization-activated...	31	2.8
54	ERG6_NEUCR (Q9P3R1) Sterol 24-C-methyltransferase (EC 2.1.1.41) ...	31	2.8
55	HCN1_RAT (Q9JKB0) Potassium/sodium hyperpolarization-activated c...	31	2.8
56	HCN1_MOUSE (O88704) Potassium/sodium hyperpolarization-activated...	31	2.8
57	HCN1_RABIT (Q9MZS1) Potassium/sodium hyperpolarization-activated...	31	2.8
58	VGLD_PRVRI (P07645) Protein gp50	31	3.6
59	FREM2_LYTVA (Q9GV77) Extracellular matrix protein 3 precursor (F...	31	3.6
60	KLPA_EMENI (P28739) Kinesin-like protein klpA	30	4.8
61	STC2_STAAU (P17855) Staphylocoagulase precursor	30	6.2
62	MUC_CHICK (P01875) Ig mu chain C region	30	6.2
63	LOXC_ARATH (P38418) Lipoxygenase, chloroplast precursor (EC 1.13...	30	8.1

>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  139 bits (349), Expect = 1e-32
 Identities = 75/194 (38%), Positives = 107/194 (55%), Gaps = 4/194 (2%)
 Frame = +1

Query: 31   VKMIA--AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 204
            VK +A  +G +H  A+T DG ++ WG G  G LG G+R     P  V ++   K+  VAC
Sbjct: 3073 VKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVAC 3132

Query: 205  GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR--HTM 378
            G  H+  +SS G LYT+G  +YG+LGHGD    L P  V AL      Q++ G R   T+
Sbjct: 3133 GSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTL 3192

Query: 379  ALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNV 558
            ALT DG ++ WG   FG++G G +    +P ++       V Q+ CG + +LA T    V
Sbjct: 3193 ALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEV 3252

Query: 559  FAWGRGTSGQLGHG 600
            + WG+G   +LGHG
Sbjct: 3253 WTWGKGDYYRLGHG 3266



 Score =  135 bits (340), Expect = 1e-31
 Identities = 69/213 (32%), Positives = 114/213 (53%), Gaps = 2/213 (0%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            EA     ++ +A G+ H+AA++  G++Y WG G YG LG GD   +  P+ V+++ G ++
Sbjct: 3120 EALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRV 3179

Query: 190  VLVACGWR--HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            V VACG R   T+ ++  G+++++G   +G+LG G  E    PH++E L      QI  G
Sbjct: 3180 VQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECG 3239

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
             + ++ALT  G+++ WG   + ++G G +     P  +     ++V  VA G  H LA T
Sbjct: 3240 AQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVT 3299

Query: 544  EKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            +   V+AWG    GQ G G       P ++  L
Sbjct: 3300 DAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGL 3332



 Score =  132 bits (332), Expect = 9e-31
 Identities = 71/214 (33%), Positives = 118/214 (55%), Gaps = 3/214 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E   G+SV  IA G+ H+AA+T  G +  WG GRYG LG GD  D+  P+ V ++ G + 
Sbjct: 4183 EHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRA 4242

Query: 190  VLVACGW--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            + +ACG     T+ ++   +++++G   YG+LG G  +   +P+K+E+L      ++  G
Sbjct: 4243 IDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECG 4302

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC-SPAQVNFPEEQKVAQVACGWRHTLAF 540
             + ++ALT  G +Y WG   F ++G G + DH   P +V   + +K+  +A G  H +A 
Sbjct: 4303 SQFSVALTKSGAVYTWGKGDFHRLGHG-SVDHVRRPKKVAALQGKKIISIATGSLHCVAC 4361

Query: 541  TEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            ++   V+ WG    GQLG G +     P ++ AL
Sbjct: 4362 SDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAAL 4395



 Score =  131 bits (330), Expect = 2e-30
 Identities = 73/215 (33%), Positives = 117/215 (54%), Gaps = 5/215 (2%)
 Frame = +1

Query: 13   AFEGISVKMIA--AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
            + + + VK +A  +G +H  A+T +G++Y WG G  G LG G+R     P+ V  + G  
Sbjct: 4130 SLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMS 4189

Query: 187  MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--G 360
            +  +ACG  H+  +++SG + T+G  +YG+LGHGD ED L P  VEAL       I+   
Sbjct: 4190 VADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGS 4249

Query: 361  GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLA 537
            G   T+ +T D  ++ WG   +G++G G  +D C  P ++       V +V CG + ++A
Sbjct: 4250 GDAQTLCITDDDNVWSWGDGDYGKLGRG-GSDGCKLPYKIESLAGLGVVKVECGSQFSVA 4308

Query: 538  FTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
             T+   V+ WG+G   +LGHG +     P  + AL
Sbjct: 4309 LTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAAL 4343



 Score =  126 bits (317), Expect = 5e-29
 Identities = 74/206 (35%), Positives = 113/206 (54%), Gaps = 4/206 (1%)
 Frame = +1

Query: 40   IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD--KMVLVACGWR 213
            IA G++    V++DG +Y  G G  G LGLG  ++  +P ++  +     K V V  G +
Sbjct: 3024 IAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK 3083

Query: 214  HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 393
            H + ++  G ++++G  + G+LGHG+      P  VEAL+      ++ G  H+ A++S 
Sbjct: 3084 HALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQ 3143

Query: 394  GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--HTLAFTEKKNVFAW 567
            G+LY WG  ++G++G GDN     P  V     ++V QVACG R   TLA TE   VF+W
Sbjct: 3144 GELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSW 3203

Query: 568  GRGTSGQLGHGEIVDRNTPVIIDALS 645
            G G  G+LG G     +TP  I+ LS
Sbjct: 3204 GDGDFGKLGRGGSEGSDTPHEIERLS 3229



 Score =  116 bits (291), Expect = 5e-26
 Identities = 68/216 (31%), Positives = 111/216 (51%), Gaps = 4/216 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--D 183
            EA   +    +A G +   AVT DG ++  G+G  G LG+G  +   +P  + S++    
Sbjct: 4077 EALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFV 4136

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            K V V  G +H + +++ G +Y +G  + G+LGHG+   +  P  VE L   S + I+ G
Sbjct: 4137 KKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACG 4196

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLA 537
              H+ A+T+ G +  WG  ++G++G GD+ D   P  V      +   +ACG     TL 
Sbjct: 4197 SAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLC 4256

Query: 538  FTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
             T+  NV++WG G  G+LG G       P  I++L+
Sbjct: 4257 ITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLA 4292



 Score =  107 bits (268), Expect = 2e-23
 Identities = 61/180 (33%), Positives = 95/180 (52%), Gaps = 2/180 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
            EA  G     IA G+    T  +T+D +++ WG G YG LG G  +   +P K+ S+ G 
Sbjct: 4235 EALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGL 4294

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
             +V V CG + ++ ++ SG++YT+G   + +LGHG  +    P KV AL+      I+ G
Sbjct: 4295 GVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATG 4354

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
              H +A +  G++Y WG N  GQ+G G       P  V   + + + +V CG  HTLA +
Sbjct: 4355 SLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALS 4414



 Score =  106 bits (264), Expect = 7e-23
 Identities = 57/187 (30%), Positives = 97/187 (51%), Gaps = 2/187 (1%)
 Frame = +1

Query: 88   IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 267
            IYGWG    G LG  + +    P    ++   + V +A G +    V+  G L+  G+  
Sbjct: 4051 IYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGS 4110

Query: 268  YGQLGHGDFEDHLVPHKVEALKDSSTSQ--ISGGWRHTMALTSDGKLYGWGWNKFGQVGA 441
             G+LG G  +   +P  + +L+     +  ++ G +H +ALT++G++Y WG  + G++G 
Sbjct: 4111 GGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGH 4170

Query: 442  GDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNT 621
            G+   +  P  V       VA +ACG  H+ A T   +V  WG+G  G+LGHG+  D+  
Sbjct: 4171 GNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLR 4230

Query: 622  PVIIDAL 642
            P +++AL
Sbjct: 4231 PKLVEAL 4237



 Score =  105 bits (263), Expect = 9e-23
 Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 2/208 (0%)
 Frame = +1

Query: 1    IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
            + H+ F  IS+     G  H  A+  + + Y WG G    LG GD + R VP K++++E 
Sbjct: 611  VAHDVF--ISIAGHCEG-RHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQ 667

Query: 181  DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS- 357
              +  V CG  ++  ++  G+L T+G   Y +LGHG+ +D  +P  V AL D     ++ 
Sbjct: 668  HCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVAL 727

Query: 358  -GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTL 534
              G  H++ALTS+G ++ WG   +G++G G+      P  V      +V +V  G + ++
Sbjct: 728  GSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVE--SLPRVQRVFAGSQFSV 785

Query: 535  AFTEKKNVFAWGRGTSGQLGHGEIVDRN 618
            A + +  ++ WG+ T   LGH ++V+R+
Sbjct: 786  ALSSEGQLYTWGKATC--LGH-QLVERS 810



 Score =  104 bits (260), Expect = 2e-22
 Identities = 56/178 (31%), Positives = 94/178 (52%), Gaps = 2/178 (1%)
 Frame = +1

Query: 13   AFEGISVKMIAAGAE--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
            A  G  V  +A G+    T A+TEDG ++ WG G +G LG G       P ++  + G  
Sbjct: 3173 ALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIG 3232

Query: 187  MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
            +V + CG + ++ ++ +G ++T+G   Y +LGHG  +    P  +  L+      ++ G 
Sbjct: 3233 VVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGA 3292

Query: 367  RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
             H +A+T  G++Y WG N  GQ G+G+   +  PA V   +   V +VACG  H++A+
Sbjct: 3293 LHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAW 3350



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 57/207 (27%), Positives = 98/207 (47%), Gaps = 5/207 (2%)
 Frame = +1

Query: 40   IAAGAEHTAAVTEDG---DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
            ++   E  AA  E      +  WG      LG    +   VP    ++   + + +A G 
Sbjct: 2969 VSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGS 3028

Query: 211  RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMAL 384
            +    VS  G +Y  G    G+LG G   +  +PH++  L+     +++   G +H +AL
Sbjct: 3029 KSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALAL 3088

Query: 385  TSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFA 564
            T DGK++ WG  + G++G G+      P  V     +K+  VACG  H+ A + +  ++ 
Sbjct: 3089 TLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYT 3148

Query: 565  WGRGTSGQLGHGEIVDRNTPVIIDALS 645
            WG G  G+LGHG+   +  P ++ AL+
Sbjct: 3149 WGLGEYGRLGHGDNTTQLKPKLVTALA 3175



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 57/208 (27%), Positives = 97/208 (46%), Gaps = 4/208 (1%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVA--C 204
            +K +A        ++++G +Y W   +              P  +  V  D  + +A  C
Sbjct: 574  IKQVACCETQMLILSQEGKLYTWRLAK----------PEAEPLPMEEVAHDVFISIAGHC 623

Query: 205  GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
              RH + + S+ + Y++G  +  +LGHGD     VP K+ AL+      +  G  ++ A+
Sbjct: 624  EGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAI 683

Query: 385  TSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLAFTEKKNV 558
            T  G L  WG   + ++G G++ D   P  V    +  V  VA G    H+LA T +  V
Sbjct: 684  TCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLV 743

Query: 559  FAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            FAWG G  G+LG+G       P+++++L
Sbjct: 744  FAWGDGDYGKLGNGNCNGSLQPILVESL 771



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 42/127 (33%), Positives = 72/127 (56%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E+  G+ V  +  G++ + A+T+ G +Y WG G +  LG G  +    P+KV++++G K+
Sbjct: 4289 ESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKI 4348

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
            + +A G  H +  S SG +YT+G +  GQLG G       P  V AL+     +++ G  
Sbjct: 4349 ISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSA 4408

Query: 370  HTMALTS 390
            HT+AL++
Sbjct: 4409 HTLALST 4415



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 44/139 (31%), Positives = 72/139 (51%), Gaps = 2/139 (1%)
 Frame = +1

Query: 235  SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 414
            + ++Y +G +  GQLG  +      P   EAL      Q++GG +   A+T DGKL+  G
Sbjct: 4048 ASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATG 4107

Query: 415  WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGTSGQ 588
            +   G++G G +     P  +   +   V +VA   G +H LA T +  V+AWG G  G+
Sbjct: 4108 YGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGK 4167

Query: 589  LGHGEIVDRNTPVIIDALS 645
            LGHG  +  + P +++ L+
Sbjct: 4168 LGHGNRMSYDRPKLVEHLN 4186



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 60/220 (27%), Positives = 90/220 (40%), Gaps = 16/220 (7%)
 Frame = +1

Query: 34   KMIAAGAEHTAAVTEDGD---IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD------- 183
            + +  G + TAA +       IY  GW       L      F  E   S  G+       
Sbjct: 514  RCLLRGGQATAASSSSAPQQRIYALGWP-----SLSKDQQGFSAEPTLSWSGESAGVPTL 568

Query: 184  ----KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ 351
                ++  VAC     + +S  G LYT+  +K              P  +E +       
Sbjct: 569  SCRFQIKQVACCETQMLILSQEGKLYTWRLAK----------PEAEPLPMEEVAHDVFIS 618

Query: 352  ISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR 525
            I+G    RH +A+ S+   Y WG  +  ++G GD      P ++   E+  V  V CG  
Sbjct: 619  IAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCS 678

Query: 526  HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
            ++ A T   N+  WGRGT  +LGHG   DR+ P ++ ALS
Sbjct: 679  YSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALS 718



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 37/124 (29%), Positives = 64/124 (51%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E   GI V  I  GA+ + A+T  G+++ WG G Y  LG G       P+ +  + G ++
Sbjct: 3226 ERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRV 3285

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
            + VA G  H + V+ +G +Y +G + +GQ G G+   +  P  V  L     ++++ G  
Sbjct: 3286 IHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSS 3345

Query: 370  HTMA 381
            H++A
Sbjct: 3346 HSIA 3349



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 26/75 (34%), Positives = 41/75 (54%)
 Frame = +1

Query: 13   AFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 192
            A +G  +  IA G+ H  A ++ G++Y WG    G LG G       P  V++++G  +V
Sbjct: 4342 ALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIV 4401

Query: 193  LVACGWRHTITVSSS 237
             V CG  HT+ +S+S
Sbjct: 4402 KVTCGSAHTLALSTS 4416



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 24/78 (30%), Positives = 45/78 (57%), Gaps = 2/78 (2%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR--FVPEKVSSVEGDKMVLVAC 204
            V+ + AG++ + A++ +G +Y WG        L +R+ +   VP  VSS++  ++V VA 
Sbjct: 774  VQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAV 833

Query: 205  GWRHTITVSSSGSLYTYG 258
               H + +SSSG ++ +G
Sbjct: 834  SVAHCLALSSSGEVFGWG 851

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>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  139 bits (349), Expect = 1e-32
 Identities = 68/197 (34%), Positives = 106/197 (53%), Gaps = 2/197 (1%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF-VPEKVSSVEGDKMVLVACGWRH 216
           +A G  H+ A+++ G ++ WG G  G LGL    D   VP  +  +    ++ V+CG  H
Sbjct: 89  VACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWH 148

Query: 217 TITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 393
            + +++ G  +T+G + +GQLG G +F     P +V +L+    +Q++ G  H+ AL+  
Sbjct: 149 CLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLS 208

Query: 394 GKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGR 573
           G ++GWG N  GQ+G  D  D  SP  V     QKV  ++CG  HT   T+   VF +G 
Sbjct: 209 GAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGA 268

Query: 574 GTSGQLGHGEIVDRNTP 624
           G+ GQLGH  + D   P
Sbjct: 269 GSCGQLGHDSMNDEVNP 285



 Score =  125 bits (315), Expect = 8e-29
 Identities = 72/207 (34%), Positives = 109/207 (52%), Gaps = 2/207 (0%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 207
           SVK +A G  H+  + EDG++Y  G    G LG     ++  PE++ ++    ++ VACG
Sbjct: 35  SVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALADQHIIHVACG 92

Query: 208 WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHL-VPHKVEALKDSSTSQISGGWRHTMAL 384
             H++ +S  G L+++G    GQLG    ED + VP  ++ L   +  Q+S G  H +AL
Sbjct: 93  ESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLAL 152

Query: 385 TSDGKLYGWGWNKFGQVGAGDN-ADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 561
            +DG+ + WG N  GQ+G G       SP +V   E   +AQVA G  H+ A +    VF
Sbjct: 153 AADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVF 212

Query: 562 AWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            WG   +GQLG  +  DR +P  +  L
Sbjct: 213 GWGMNNAGQLGLSDEKDRESPCHVKLL 239



 Score =  118 bits (295), Expect = 2e-26
 Identities = 68/201 (33%), Positives = 103/201 (51%), Gaps = 2/201 (0%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKVSSVEGDKMVLVAC 204
           ++  ++ G  H  A+  DG  + WG   +G LGLG     +  P++V S+EG  +  VA 
Sbjct: 138 TILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 197

Query: 205 GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
           G  H+  +S SG+++ +G +  GQLG  D +D   P  V+ L+      IS G  HT  L
Sbjct: 198 GGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 257

Query: 385 TSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN-VF 561
           T  G ++ +G    GQ+G     D  +P +V      +V Q+ACG +HTLAF      ++
Sbjct: 258 TKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIY 317

Query: 562 AWGRGTSGQLGHGEIVDRNTP 624
           A+G G  GQLG G   +   P
Sbjct: 318 AFGCGARGQLGTGHTCNVKCP 338



 Score =  113 bits (282), Expect = 6e-25
 Identities = 58/159 (36%), Positives = 87/159 (54%), Gaps = 1/159 (0%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
           R  + EGI +  +AAG  H+ A++  G ++GWG    G LGL D  DR  P  V  +   
Sbjct: 183 RVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ 242

Query: 184 KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
           K+V ++CG  HT  ++ SG ++T+G    GQLGH    D + P +V  L  S  +QI+ G
Sbjct: 243 KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACG 302

Query: 364 WRHTMA-LTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 477
            +HT+A + S G +Y +G    GQ+G G   +   P+ V
Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 341



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 39/110 (35%), Positives = 59/110 (53%), Gaps = 1/110 (0%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           V  I+ G EHTA +T+ G ++ +G G  G LG    ND   P +V  + G ++  +ACG 
Sbjct: 244 VVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGR 303

Query: 211 RHTIT-VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS 357
           +HT+  V SSG +Y +G    GQLG G   +   P  V+    + + Q+S
Sbjct: 304 QHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLS 353



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 37/116 (31%), Positives = 60/116 (51%), Gaps = 2/116 (1%)
 Frame = +1

Query: 253 YGWSKYGQLGHGDFEDHLV--PHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
           +G+   GQ G       +V  P     + D S  +++ G  H++ L  DG++Y  G N  
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 427 GQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
           GQ+G     +   P Q+    +Q +  VACG  H+LA +++  +F+WG G+ GQLG
Sbjct: 64  GQLGHEREGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
 Frame = +1

Query: 409 WGWNKFGQVGAGDNADH--CSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTS 582
           WG+   GQ G   N       P    F  ++ V +VACG  H++   E   V+  G  T 
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 583 GQLGHGEIVDRNTPVIIDALS 645
           GQLGH    + N P  I AL+
Sbjct: 64  GQLGHER--EGNKPEQIGALA 82

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  136 bits (342), Expect = 6e-32
 Identities = 73/213 (34%), Positives = 115/213 (53%), Gaps = 2/213 (0%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E+  GI V  +AAG  H+A VT  GD+Y WG GRYG LG  D  D+  P+ V +++G ++
Sbjct: 4086 ESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRV 4145

Query: 190  VLVACGW--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            V +ACG     T+ ++   +++++G   YG+LG G  +   VP K+++L      ++  G
Sbjct: 4146 VDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECG 4205

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
             + ++ALT  G +Y WG   + ++G G +     P QV   + +KV  +A G  H +  T
Sbjct: 4206 SQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 4265

Query: 544  EKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            E   V+ WG    GQLG G       P ++ AL
Sbjct: 4266 EDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAAL 4298



 Score =  135 bits (340), Expect = 1e-31
 Identities = 70/213 (32%), Positives = 111/213 (52%), Gaps = 2/213 (0%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            EA +   ++ IA G+ H+AA+T  G++Y WG G YG LG GD   +  P+ V  + G ++
Sbjct: 3094 EALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRV 3153

Query: 190  VLVACGWR--HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            + VACG R   T+ ++  G ++++G   +G+LG G  E   +P  +E L      QI  G
Sbjct: 3154 IQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECG 3213

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
             + ++ALT  G ++ WG   + ++G G +     P  V     +K+  VA G  H LA T
Sbjct: 3214 AQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVT 3273

Query: 544  EKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            +   V+AWG    GQ G+G       P ++  L
Sbjct: 3274 DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306



 Score =  134 bits (338), Expect = 2e-31
 Identities = 74/214 (34%), Positives = 114/214 (53%), Gaps = 4/214 (1%)
 Frame = +1

Query: 13   AFEGISVKMIA--AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
            A     VK +A  +G  H  A+T DG ++ WG G  G LG   R +   P  + +++  +
Sbjct: 3041 ALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKR 3100

Query: 187  MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
            +  +ACG  H+  ++SSG LYT+G  +YG+LGHGD    L P  V+ L      Q++ G 
Sbjct: 3101 IRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160

Query: 367  R--HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
            R   T+ALT +G ++ WG   FG++G G +     P  +     Q V Q+ CG + +LA 
Sbjct: 3161 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLAL 3220

Query: 541  TEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            T+   V+ WG+G   +LGHG  V    P +++ L
Sbjct: 3221 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGL 3254



 Score =  132 bits (332), Expect = 9e-31
 Identities = 71/202 (35%), Positives = 116/202 (57%), Gaps = 5/202 (2%)
 Frame = +1

Query: 10   EAFEGISVKMIA--AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
            E+ + + +K +A  +G +H  A++ +G++Y WG    G LG G+R+    P  + S+ G 
Sbjct: 4032 ESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGI 4091

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-- 357
            ++V VA G  H+  V+++G LYT+G  +YG+LGH D ED L P  VEAL+      I+  
Sbjct: 4092 EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACG 4151

Query: 358  GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTL 534
             G   T+ LT D  ++ WG   +G++G G  +D C  P +++      V +V CG + ++
Sbjct: 4152 SGDAQTLCLTDDDTVWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSV 4210

Query: 535  AFTEKKNVFAWGRGTSGQLGHG 600
            A T+   V+ WG+G   +LGHG
Sbjct: 4211 ALTKSGAVYTWGKGDYHRLGHG 4232



 Score =  125 bits (313), Expect = 1e-28
 Identities = 76/217 (35%), Positives = 113/217 (52%), Gaps = 5/217 (2%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF-VPEKVSSVEGD- 183
            E    ++V  +A G++   AVT +G +Y  G    G LGLG  +    +P +++++    
Sbjct: 2987 ETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYV 3046

Query: 184  -KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISG 360
             K V V  G RH   ++  G ++++G    G+LGH    +   P  +EALK      I+ 
Sbjct: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106

Query: 361  GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--HTL 534
            G  H+ ALTS G+LY WG  ++G++G GDN     P  V      +V QVACG R   TL
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTL 3166

Query: 535  AFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
            A T++  VF+WG G  G+LG G     N P  I+ L+
Sbjct: 3167 ALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN 3203



 Score =  124 bits (310), Expect = 3e-28
 Identities = 66/211 (31%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
 Frame = +1

Query: 31   VKMIA-AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK----MVL 195
            VK+ A +   H  A+   G++Y WG G  G LG GD      P+ +S+  G +    +V 
Sbjct: 496  VKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVH 555

Query: 196  VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWR 369
            +ACG  ++  +++ G LYT+G   YG+LGHG  ED  +P  V  LK      ++   G  
Sbjct: 556  IACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDA 615

Query: 370  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 549
             T+A+T +G+++ WG   +G++G G +    +P  +   ++  V +V CG + ++A T+ 
Sbjct: 616  QTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKD 675

Query: 550  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
              V++WG+G + +LGHG       P +++ L
Sbjct: 676  GQVYSWGKGDNQRLGHGTEEHVRYPKLLEGL 706



 Score =  121 bits (304), Expect = 2e-27
 Identities = 68/216 (31%), Positives = 110/216 (50%), Gaps = 4/216 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--D 183
            EA   +    +  G +   AVT DG +Y  G+G  G LG+G       P  + S++    
Sbjct: 3980 EALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFI 4039

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            K V V  G +H + +SS G +Y++G ++ G+LGHG+      P  +E+L+      ++ G
Sbjct: 4040 KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG 4099

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLA 537
              H+  +T+ G LY WG  ++G++G  D+ D   P  V   +  +V  +ACG     TL 
Sbjct: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159

Query: 538  FTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
             T+   V++WG G  G+LG G       P+ ID+L+
Sbjct: 4160 LTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLT 4195



 Score =  121 bits (304), Expect = 2e-27
 Identities = 65/185 (35%), Positives = 102/185 (55%), Gaps = 2/185 (1%)
 Frame = +1

Query: 22   GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVA 201
            G  V  IA G+ ++AA+T +G++Y WG G YG LG G   D  +P  V+ ++G K++ VA
Sbjct: 550  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609

Query: 202  CGW--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 375
            CG     T+ V+ +G ++++G   YG+LG G  +    P  +E L+D    ++  G + +
Sbjct: 610  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669

Query: 376  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 555
            +ALT DG++Y WG     ++G G       P  +   + +KV  VA G  H LA TE   
Sbjct: 670  IALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSE 729

Query: 556  VFAWG 570
            V +WG
Sbjct: 730  VHSWG 734



 Score =  117 bits (294), Expect = 2e-26
 Identities = 67/183 (36%), Positives = 100/183 (54%), Gaps = 2/183 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
            EA +G  V  IA G+    T  +T+D  ++ WG G YG LG G  +   VP K+ S+ G 
Sbjct: 4138 EALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGL 4197

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
             +V V CG + ++ ++ SG++YT+G   Y +LGHG  +    P +V+ L+      I+ G
Sbjct: 4198 GVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATG 4257

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
              H +  T DG++Y WG N  GQ+G G       P  V   + +KV +VACG  HTLA++
Sbjct: 4258 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4317

Query: 544  EKK 552
              K
Sbjct: 4318 TSK 4320



 Score =  110 bits (274), Expect = 5e-24
 Identities = 57/176 (32%), Positives = 93/176 (52%), Gaps = 2/176 (1%)
 Frame = +1

Query: 22   GISVKMIAAGAE--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 195
            G  V  +A G+    T A+T++G ++ WG G +G LG G      +P+ +  + G  +  
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3209

Query: 196  VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 375
            + CG + ++ ++ SG ++T+G   Y +LGHG       P  VE L+      ++ G  H 
Sbjct: 3210 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3269

Query: 376  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
            +A+T  G++Y WG N  GQ G G    +  P  V   E QK+ +VACG  H++A+T
Sbjct: 3270 LAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 56/196 (28%), Positives = 98/196 (50%), Gaps = 2/196 (1%)
 Frame = +1

Query: 61   TAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSG 240
            T +    G IYGWG    G LG  +     VP    ++   + V +  G +    V++ G
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4004

Query: 241  SLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGKLYGWG 414
             LY  G+   G+LG G  E    P  +E+++     +++   G +H +AL+S+G++Y WG
Sbjct: 4005 KLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWG 4064

Query: 415  WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
              + G++G G+ +    P  +      +V  VA G  H+   T   +++ WG+G  G+LG
Sbjct: 4065 EAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG 4124

Query: 595  HGEIVDRNTPVIIDAL 642
            H +  D+  P +++AL
Sbjct: 4125 HSDSEDQLKPKLVEAL 4140



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 53/185 (28%), Positives = 89/185 (48%), Gaps = 10/185 (5%)
 Frame = +1

Query: 19   EGISVKMIAAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 192
            +G+ V  +A G+    T AVTE+G ++ WG G YG LG G  +    P+ +  ++   +V
Sbjct: 601  KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV 660

Query: 193  LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRH 372
             V CG + +I ++  G +Y++G     +LGHG  E    P  +E L+      ++ G  H
Sbjct: 661  KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 720

Query: 373  TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPE--------EQKVAQVACGWRH 528
             +ALT D +++ WG N        D   H    +V  PE         + +  +ACG   
Sbjct: 721  CLALTEDSEVHSWGSN--------DQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQ 772

Query: 529  TLAFT 543
            + A++
Sbjct: 773  SFAWS 777



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 41/127 (32%), Positives = 67/127 (52%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E   G  V  I  GA+ + A+T+ G ++ WG G Y  LG G       P+ V  + G K+
Sbjct: 3200 ERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKI 3259

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
            V VA G  H + V+ SG +Y +G + +GQ G+G    +  P  V+ L+    ++++ G  
Sbjct: 3260 VHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSS 3319

Query: 370  HTMALTS 390
            H++A T+
Sbjct: 3320 HSVAWTT 3326



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 52/175 (29%), Positives = 81/175 (46%), Gaps = 3/175 (1%)
 Frame = +1

Query: 127  LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHL 306
            L   N+    EK +S  G  +   A G     T+ +   ++ +G +   QLG        
Sbjct: 2926 LASDNEEEEDEKGNS--GSLIRKKAAGLESAATIRTK--VFVWGLNDKDQLGGLKGSKIK 2981

Query: 307  VPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNF 483
            VP   E L   +  Q++GG +   A+T +GK+Y  G    G++G G ++     P Q+  
Sbjct: 2982 VPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITA 3041

Query: 484  PEEQKVAQVA--CGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
                 V +VA   G RH  A T    VF+WG G  G+LGH   ++ + P +I+AL
Sbjct: 3042 LSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEAL 3096



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 22/83 (26%), Positives = 44/83 (53%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           E  + + V  +  G++ + A+T+DG +Y WG G    LG G       P+ +  ++G K+
Sbjct: 652 EKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKV 711

Query: 190 VLVACGWRHTITVSSSGSLYTYG 258
           + VA G  H + ++    ++++G
Sbjct: 712 IDVAAGSTHCLALTEDSEVHSWG 734



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 38/142 (26%), Positives = 64/142 (45%), Gaps = 3/142 (2%)
 Frame = +1

Query: 229 SSSGSLY-TYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 405
           S  GSL    GW   G +G   + + + P + E L +   +QI+   +  + L+ +G++Y
Sbjct: 417 SHKGSLQEVIGW---GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVY 473

Query: 406 GWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGT 579
              +N          +D  +P  V     + + ++A      H LA      V++WG G 
Sbjct: 474 TQAYN----------SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGD 523

Query: 580 SGQLGHGEIVDRNTPVIIDALS 645
            G+LGHG+ V    P +I A S
Sbjct: 524 GGRLGHGDTVPLEEPKVISAFS 545

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>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  135 bits (341), Expect = 8e-32
 Identities = 72/213 (33%), Positives = 115/213 (53%), Gaps = 2/213 (0%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E+  GI V  +AAG  H+A VT  GD+Y WG GRYG LG  D  D+  P+ V +++G ++
Sbjct: 4088 ESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRV 4147

Query: 190  VLVACGW--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            + +ACG     T+ ++   +++++G   YG+LG G  +   VP K+++L      ++  G
Sbjct: 4148 IDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECG 4207

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
             + ++ALT  G +Y WG   + ++G G +     P QV   + +KV  +A G  H +  T
Sbjct: 4208 SQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 4267

Query: 544  EKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            E   V+ WG    GQLG G       P ++ AL
Sbjct: 4268 EDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAAL 4300



 Score =  132 bits (332), Expect = 9e-31
 Identities = 71/202 (35%), Positives = 116/202 (57%), Gaps = 5/202 (2%)
 Frame = +1

Query: 10   EAFEGISVKMIA--AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
            E+ + + +K +A  +G +H  A++ +G++Y WG    G LG G+R+    P  + S+ G 
Sbjct: 4034 ESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGI 4093

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-- 357
            ++V VA G  H+  V+++G LYT+G  +YG+LGH D ED L P  VEAL+      I+  
Sbjct: 4094 EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACG 4153

Query: 358  GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTL 534
             G   T+ LT D  ++ WG   +G++G G  +D C  P +++      V +V CG + ++
Sbjct: 4154 SGDAQTLCLTDDDTVWSWGDGDYGKLGRG-GSDGCKVPMKIDSLTGLGVVKVECGSQFSV 4212

Query: 535  AFTEKKNVFAWGRGTSGQLGHG 600
            A T+   V+ WG+G   +LGHG
Sbjct: 4213 ALTKSGAVYTWGKGDYHRLGHG 4234



 Score =  131 bits (330), Expect = 2e-30
 Identities = 68/213 (31%), Positives = 110/213 (51%), Gaps = 2/213 (0%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            +A +   ++ IA G+ H+A +T  G++Y WG G YG LG GD   +  P+ V  + G ++
Sbjct: 3095 QALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRV 3154

Query: 190  VLVACGWR--HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            + VACG R   T+ ++  G ++++G   +G+LG G  E   +P  +E L      QI  G
Sbjct: 3155 IQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECG 3214

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
             + ++ALT  G ++ WG   + ++G G +     P  V     +K+  VA G  H LA T
Sbjct: 3215 AQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVT 3274

Query: 544  EKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            +   V+AWG    GQ G+G       P ++  L
Sbjct: 3275 DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3307



 Score =  130 bits (326), Expect = 4e-30
 Identities = 73/214 (34%), Positives = 113/214 (52%), Gaps = 4/214 (1%)
 Frame = +1

Query: 13   AFEGISVKMIA--AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
            A     VK +A  +G  H  A+T DG ++ WG G  G LG   R +   P  + +++  +
Sbjct: 3042 ALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKR 3101

Query: 187  MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
            +  +A G  H+  ++SSG LYT+G  +YG+LGHGD    L P  V+ L      Q++ G 
Sbjct: 3102 IRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3161

Query: 367  R--HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
            R   T+ALT +G ++ WG   FG++G G +     P  +     Q V Q+ CG + +LA 
Sbjct: 3162 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLAL 3221

Query: 541  TEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            T+   V+ WG+G   +LGHG  V    P +++ L
Sbjct: 3222 TKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGL 3255



 Score =  123 bits (309), Expect = 4e-28
 Identities = 66/211 (31%), Positives = 114/211 (54%), Gaps = 7/211 (3%)
 Frame = +1

Query: 31   VKMIA-AGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK----MVL 195
            VK+ A +   H  A+   G++Y WG G  G LG GD      P+ +S+  G +    +V 
Sbjct: 497  VKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVH 556

Query: 196  VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWR 369
            +ACG  ++  +++ G LYT+G   YG+LGHG  ED  +P  V  LK      ++   G  
Sbjct: 557  IACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDA 616

Query: 370  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 549
             T+A+T +G+++ WG   +G++G G +    +P  +   ++  V +V CG + ++A T+ 
Sbjct: 617  QTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKD 676

Query: 550  KNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
              V++WG+G + +LGHG       P +++ L
Sbjct: 677  GQVYSWGKGDNQRLGHGTEEHVRYPKLLEGL 707



 Score =  122 bits (305), Expect = 1e-27
 Identities = 74/217 (34%), Positives = 112/217 (51%), Gaps = 5/217 (2%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF-VPEKVSSVEGD- 183
            E    ++V  +A G++   AVT +G +Y  G    G LGLG  +    +P +++++    
Sbjct: 2988 ETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYV 3047

Query: 184  -KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISG 360
             K V V  G RH   ++  G ++++G    G+LGH    +   P  ++ALK      I+ 
Sbjct: 3048 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAY 3107

Query: 361  GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR--HTL 534
            G  H+  LTS G+LY WG  ++G++G GDN     P  V      +V QVACG R   TL
Sbjct: 3108 GSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTL 3167

Query: 535  AFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
            A T++  VF+WG G  G+LG G     N P  I+ L+
Sbjct: 3168 ALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN 3204



 Score =  121 bits (303), Expect = 2e-27
 Identities = 68/216 (31%), Positives = 110/216 (50%), Gaps = 4/216 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--D 183
            EA   +    +  G +   AVT DG +Y  G+G  G LG+G       P  + S++    
Sbjct: 3982 EALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFI 4041

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            K V V  G +H + +SS G +Y++G ++ G+LGHG+      P  +E+L+      ++ G
Sbjct: 4042 KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG 4101

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGW--RHTLA 537
              H+  +T+ G LY WG  ++G++G  D+ D   P  V   +  +V  +ACG     TL 
Sbjct: 4102 GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLC 4161

Query: 538  FTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
             T+   V++WG G  G+LG G       P+ ID+L+
Sbjct: 4162 LTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLT 4197



 Score =  120 bits (300), Expect = 5e-27
 Identities = 64/185 (34%), Positives = 101/185 (54%), Gaps = 2/185 (1%)
 Frame = +1

Query: 22   GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVA 201
            G  V  IA G+ ++AA+T +G++Y WG G YG LG G   D  +P  V+ ++G K++ VA
Sbjct: 551  GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 610

Query: 202  CGW--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 375
            CG     T+ V+ +G ++++G   YG+LG G  +    P  +E L+D    ++  G + +
Sbjct: 611  CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFS 670

Query: 376  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 555
            +ALT DG++Y WG     ++G G       P  +   + +KV  VA G  H L  TE   
Sbjct: 671  IALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLVLTEDSE 730

Query: 556  VFAWG 570
            V +WG
Sbjct: 731  VHSWG 735



 Score =  117 bits (293), Expect = 3e-26
 Identities = 67/183 (36%), Positives = 100/183 (54%), Gaps = 2/183 (1%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
            EA +G  V  IA G+    T  +T+D  ++ WG G YG LG G  +   VP K+ S+ G 
Sbjct: 4140 EALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGL 4199

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
             +V V CG + ++ ++ SG++YT+G   Y +LGHG  +    P +V+ L+      I+ G
Sbjct: 4200 GVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATG 4259

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
              H +  T DG++Y WG N  GQ+G G       P  V   + +KV +VACG  HTLA++
Sbjct: 4260 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4319

Query: 544  EKK 552
              K
Sbjct: 4320 TSK 4322



 Score =  110 bits (274), Expect = 5e-24
 Identities = 57/176 (32%), Positives = 93/176 (52%), Gaps = 2/176 (1%)
 Frame = +1

Query: 22   GISVKMIAAGAE--HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 195
            G  V  +A G+    T A+T++G ++ WG G +G LG G      +P+ +  + G  +  
Sbjct: 3151 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3210

Query: 196  VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHT 375
            + CG + ++ ++ SG ++T+G   Y +LGHG       P  VE L+      ++ G  H 
Sbjct: 3211 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3270

Query: 376  MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
            +A+T  G++Y WG N  GQ G G    +  P  V   E QK+ +VACG  H++A+T
Sbjct: 3271 LAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3326



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 56/196 (28%), Positives = 98/196 (50%), Gaps = 2/196 (1%)
 Frame = +1

Query: 61   TAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSG 240
            T +    G IYGWG    G LG  +     VP    ++   + V +  G +    V++ G
Sbjct: 3947 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4006

Query: 241  SLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGKLYGWG 414
             LY  G+   G+LG G  E    P  +E+++     +++   G +H +AL+S+G++Y WG
Sbjct: 4007 KLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWG 4066

Query: 415  WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
              + G++G G+ +    P  +      +V  VA G  H+   T   +++ WG+G  G+LG
Sbjct: 4067 EAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG 4126

Query: 595  HGEIVDRNTPVIIDAL 642
            H +  D+  P +++AL
Sbjct: 4127 HSDSEDQLKPKLVEAL 4142



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 51/179 (28%), Positives = 88/179 (49%), Gaps = 4/179 (2%)
 Frame = +1

Query: 19   EGISVKMIAAGA--EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 192
            +G+ V  +A G+    T AVTE+G ++ WG G YG LG G  +    P+ +  ++   ++
Sbjct: 602  KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVI 661

Query: 193  LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRH 372
             V CG + +I ++  G +Y++G     +LGHG  E    P  +E L+      ++ G  H
Sbjct: 662  KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 721

Query: 373  TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRHTLAFT 543
             + LT D +++ WG N   Q    D      P    FP  + + +  +ACG   + A++
Sbjct: 722  CLVLTEDSEVHSWGSN--DQCQHFDTLGVTKPEPTAFPGLDSKHIVGIACGPAQSFAWS 778



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 41/127 (32%), Positives = 67/127 (52%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E   G  V  I  GA+ + A+T+ G ++ WG G Y  LG G       P+ V  + G K+
Sbjct: 3201 ERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKI 3260

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
            V VA G  H + V+ SG +Y +G + +GQ G+G    +  P  V+ L+    ++++ G  
Sbjct: 3261 VHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSS 3320

Query: 370  HTMALTS 390
            H++A T+
Sbjct: 3321 HSVAWTT 3327



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 46/149 (30%), Positives = 71/149 (47%), Gaps = 3/149 (2%)
 Frame = +1

Query: 205  GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            G   T T+ +   ++ +G +   QLG        VP   E L   +  Q++GG +   A+
Sbjct: 2951 GLESTATIRTK--VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAV 3008

Query: 385  TSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVA--CGWRHTLAFTEKKN 555
            T +GK+Y  G    G++G G ++     P Q+       V +VA   G RH  A T    
Sbjct: 3009 TVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK 3068

Query: 556  VFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            VF+WG G  G+LGH   ++ + P +I AL
Sbjct: 3069 VFSWGEGDDGKLGHFSRMNCDKPRLIQAL 3097



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 22/83 (26%), Positives = 44/83 (53%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           E  + + V  +  G++ + A+T+DG +Y WG G    LG G       P+ +  ++G K+
Sbjct: 653 EKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKV 712

Query: 190 VLVACGWRHTITVSSSGSLYTYG 258
           + VA G  H + ++    ++++G
Sbjct: 713 IDVAAGSTHCLVLTEDSEVHSWG 735



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 37/142 (26%), Positives = 62/142 (43%), Gaps = 3/142 (2%)
 Frame = +1

Query: 229 SSSGSLY-TYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 405
           S  GSL    GW   G +G   + + + P + E L      Q++   +  + L+ +G++Y
Sbjct: 418 SHKGSLQEVIGW---GLIGWKYYANVIGPIQCEGLASLGVMQVACAEKRFLILSRNGRVY 474

Query: 406 GWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVAC--GWRHTLAFTEKKNVFAWGRGT 579
              +N          +D  +P  V     + + ++A      H LA      V++WG G 
Sbjct: 475 TQAYN----------SDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGD 524

Query: 580 SGQLGHGEIVDRNTPVIIDALS 645
            G+LGHG+ V    P +I A S
Sbjct: 525 GGRLGHGDTVPLEEPKVISAFS 546

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score =  135 bits (340), Expect = 1e-31
 Identities = 73/200 (36%), Positives = 109/200 (54%), Gaps = 3/200 (1%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
           EA  G  +K ++ G+  H    TEDG +Y WG   Y  LG G  N    P +V +    K
Sbjct: 69  EALCGKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIK 128

Query: 187 MVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISG 360
            V+ VACG  H++ +++ G L+ +G++  GQ+G G   +   P KV   L       I+ 
Sbjct: 129 QVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIAC 188

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G   +MA+   G++YGWG+N  GQ+G G+N +  +P +V       V Q+ CG+ HTLA 
Sbjct: 189 GQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLAL 248

Query: 541 TEKKNVFAWGRGTSGQLGHG 600
           T++  ++AWG  T GQLG G
Sbjct: 249 TDEGLLYAWGANTYGQLGTG 268



 Score =  128 bits (322), Expect = 1e-29
 Identities = 70/190 (36%), Positives = 108/190 (56%), Gaps = 4/190 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 216
           +A G+ H+ A+  DG+++ WG+   G +G G   ++  P KV++    K V+ +ACG   
Sbjct: 133 VACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTS 192

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 396
           ++ V  SG +Y +G++  GQLG G+  + L P +V AL     +QI  G+ HT+ALT +G
Sbjct: 193 SMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEG 252

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 570
            LY WG N +GQ+G G   +  SP Q+   +E+ +   AC   HT  A T+  +V+ WG 
Sbjct: 253 LLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHVYMWGQ 312

Query: 571 -RGTSGQLGH 597
            RG S  L H
Sbjct: 313 CRGQSVILPH 322



 Score =  114 bits (285), Expect = 3e-25
 Identities = 64/205 (31%), Positives = 109/205 (53%), Gaps = 3/205 (1%)
 Frame = +1

Query: 37  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WR 213
           +    A     VT++ +++ +G      LG GD     VP+K+ ++ G K+  ++ G   
Sbjct: 26  VFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGP 85

Query: 214 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 390
           H +  +  G +Y +G + Y QLG+G     + P +V   L      +++ G  H+MAL +
Sbjct: 86  HVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAA 145

Query: 391 DGKLYGWGWNKFGQVGAGDNADHCSPAQV-NFPEEQKVAQVACGWRHTLAFTEKKNVFAW 567
           DG+L+ WG+N  GQVG+G  A+  +P +V N    ++V  +ACG   ++A  +   V+ W
Sbjct: 146 DGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGW 205

Query: 568 GRGTSGQLGHGEIVDRNTPVIIDAL 642
           G   +GQLG G   ++ TPV + AL
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRVAAL 230



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 3/160 (1%)
 Frame = +1

Query: 154 PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK 333
           P++  S+   K  +        I V+ +  ++ +G +    LG GD +  LVP K+EAL 
Sbjct: 15  PQEAGSIR--KACVFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALC 72

Query: 334 DSSTSQIS-GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVA 504
                 +S G   H +  T DG +Y WG N + Q+G G      +P QV  N   +Q V 
Sbjct: 73  GKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VI 131

Query: 505 QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
           +VACG  H++A      +FAWG    GQ+G G   ++ TP
Sbjct: 132 EVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTP 171



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 30/90 (33%), Positives = 48/90 (53%), Gaps = 1/90 (1%)
 Frame = +1

Query: 1   IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
           +R  A  G+ V  I  G  HT A+T++G +Y WG   YG LG G +N+   P ++  VE 
Sbjct: 225 VRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQI-MVEK 283

Query: 181 DKMV-LVACGWRHTITVSSSGSLYTYGWSK 267
           ++++ + AC   HT    + G  + Y W +
Sbjct: 284 ERVIEIAACHSTHTSAAKTQGG-HVYMWGQ 312

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  132 bits (333), Expect = 7e-31
 Identities = 69/216 (31%), Positives = 123/216 (56%), Gaps = 5/216 (2%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
           R ++  G  +  ++ G+  H    T DG+++ WG   Y  LG G  N   VP  +S+   
Sbjct: 91  RLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLS 150

Query: 181 DKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQI 354
           +K V+ VACG  H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I
Sbjct: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSI 210

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTL 534
           + G   +MA+   G++Y WG+N  GQ+G G + +  +P +V   +  +V +VACG+ HTL
Sbjct: 211 ACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 535 AFTEKKNVFAWGRGTSGQLGHGEIVDRN--TPVIID 636
             T++  ++AWG  + GQLG G   +++  TPV+++
Sbjct: 271 VLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVE 306



 Score =  120 bits (300), Expect = 5e-27
 Identities = 60/190 (31%), Positives = 109/190 (57%), Gaps = 4/190 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 216
           +A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG   
Sbjct: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMC 216

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 396
           ++ V  +G +Y +G++  GQLG G   +   P +V AL+     +++ G+ HT+ LT +G
Sbjct: 217 SMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG 276

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 570
           ++Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A ++  +V+ WG 
Sbjct: 277 QIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKSQGGHVYMWGQ 336

Query: 571 -RGTSGQLGH 597
            RG S  L H
Sbjct: 337 CRGQSVILPH 346



 Score =  110 bits (275), Expect = 4e-24
 Identities = 63/193 (32%), Positives = 104/193 (53%), Gaps = 3/193 (1%)
 Frame = +1

Query: 73  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WRHTITVSSSGSLY 249
           T + +I+  G    G LG+GD      P ++ S+ G K+  ++ G   H +  ++ G ++
Sbjct: 62  TVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVF 121

Query: 250 TYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
           T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTSDG+++ WG+N  
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 427 GQVGAGDNADHCSPAQVNFPEEQKVAQ-VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           GQVG+G  A+   P +V    + KV   +ACG   ++A  +   V+ WG   +GQLG G 
Sbjct: 182 GQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGS 241

Query: 604 IVDRNTPVIIDAL 642
             ++ TP  + AL
Sbjct: 242 SGNQPTPCRVAAL 254



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 1/129 (0%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           V  IA G   + AV + G++Y WG+   G LGLG   ++  P +V++++G ++  VACG+
Sbjct: 207 VMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGY 266

Query: 211 RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 390
            HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT A  S
Sbjct: 267 AHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKS 326

Query: 391 D-GKLYGWG 414
             G +Y WG
Sbjct: 327 QGGHVYMWG 335



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 1/89 (1%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
           R  A +GI V+ +A G  HT  +T++G IY WG   YG LG G+++++  P  V  VE D
Sbjct: 250 RVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPV-VVEKD 308

Query: 184 KMV-LVACGWRHTITVSSSGSLYTYGWSK 267
           +++ + AC   HT    S G  + Y W +
Sbjct: 309 RIIEIAACHSAHTSAAKSQGG-HVYMWGQ 336

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  132 bits (333), Expect = 7e-31
 Identities = 69/216 (31%), Positives = 123/216 (56%), Gaps = 5/216 (2%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
           R ++  G  +  ++ G+  H    T DG+++ WG   Y  LG G  N   VP  +S+   
Sbjct: 91  RLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLS 150

Query: 181 DKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQI 354
           +K V+ VACG  H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I
Sbjct: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNI 210

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTL 534
           + G   +MA+   G++Y WG+N  GQ+G G + +  +P +V   +  +V +VACG+ HTL
Sbjct: 211 ACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 535 AFTEKKNVFAWGRGTSGQLGHGEIVDRN--TPVIID 636
             T++  ++AWG  + GQLG G   +++  TPV+++
Sbjct: 271 VLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVE 306



 Score =  121 bits (304), Expect = 2e-27
 Identities = 61/190 (32%), Positives = 109/190 (57%), Gaps = 4/190 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 216
           +A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG   
Sbjct: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMC 216

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 396
           ++ V  +G +Y +G++  GQLG G   +   P +V AL+     +++ G+ HT+ LT +G
Sbjct: 217 SMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG 276

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 570
           ++Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A T+  +V+ WG 
Sbjct: 277 QIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQ 336

Query: 571 -RGTSGQLGH 597
            RG S  L H
Sbjct: 337 CRGQSVILPH 346



 Score =  110 bits (275), Expect = 4e-24
 Identities = 63/193 (32%), Positives = 104/193 (53%), Gaps = 3/193 (1%)
 Frame = +1

Query: 73  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WRHTITVSSSGSLY 249
           T + +I+  G    G LG+GD      P ++ S+ G K+  ++ G   H +  ++ G ++
Sbjct: 62  TVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVF 121

Query: 250 TYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
           T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTSDG+++ WG+N  
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 427 GQVGAGDNADHCSPAQVNFPEEQKVAQ-VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           GQVG+G  A+   P +V    + KV   +ACG   ++A  +   V+ WG   +GQLG G 
Sbjct: 182 GQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGS 241

Query: 604 IVDRNTPVIIDAL 642
             ++ TP  + AL
Sbjct: 242 SGNQPTPCRVAAL 254



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 1/129 (0%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           V  IA G   + AV + G++Y WG+   G LGLG   ++  P +V++++G ++  VACG+
Sbjct: 207 VMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGY 266

Query: 211 RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-T 387
            HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT A  T
Sbjct: 267 AHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKT 326

Query: 388 SDGKLYGWG 414
             G +Y WG
Sbjct: 327 QGGHVYMWG 335



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 32/89 (35%), Positives = 50/89 (56%), Gaps = 1/89 (1%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
           R  A +GI V+ +A G  HT  +T++G IY WG   YG LG G+++++  P  V  VE D
Sbjct: 250 RVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPV-VVEKD 308

Query: 184 KMV-LVACGWRHTITVSSSGSLYTYGWSK 267
           +++ + AC   HT    + G  + Y W +
Sbjct: 309 RIIEIAACHSAHTSAAKTQGG-HVYMWGQ 336

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score =  130 bits (328), Expect = 3e-30
 Identities = 70/200 (35%), Positives = 111/200 (55%), Gaps = 3/200 (1%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV-SSVEGD 183
           E   G  +K ++ G+  H    TEDG +Y WG   Y  LG G  N    P +V +++   
Sbjct: 69  EGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIK 128

Query: 184 KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISG 360
           ++V VACG  H++ +++ G ++ +G++  GQ+G G   +   P KV   L       I+ 
Sbjct: 129 QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G   +MA+  +G++YGWG+N  GQ+G G+N +  +P +V       V Q+ CG+ HTLA 
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248

Query: 541 TEKKNVFAWGRGTSGQLGHG 600
           T++  ++AWG  T GQLG G
Sbjct: 249 TDEGLLYAWGANTYGQLGTG 268



 Score =  127 bits (319), Expect = 3e-29
 Identities = 70/190 (36%), Positives = 109/190 (57%), Gaps = 4/190 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 216
           +A G+ H+ A+  DG+++ WG+   G +G G   ++  P KV++    K V+ +ACG   
Sbjct: 133 VACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTS 192

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 396
           ++ V  +G +Y +G++  GQLG G+  + L P +V AL     +QI  G+ HT+ALT +G
Sbjct: 193 SMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 570
            LY WG N +GQ+G G+  +  SPA +   +E+ V   AC   HT  A T+  +V+ WG 
Sbjct: 253 LLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312

Query: 571 -RGTSGQLGH 597
            RG S  L H
Sbjct: 313 CRGQSVILPH 322



 Score =  110 bits (275), Expect = 4e-24
 Identities = 63/205 (30%), Positives = 108/205 (52%), Gaps = 3/205 (1%)
 Frame = +1

Query: 37  MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WR 213
           +    A     VT++ +++ +G      LG GD     VP+K+  + G K+  ++ G   
Sbjct: 26  VFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGP 85

Query: 214 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 390
           H +  +  G +Y +G + Y QLG+G     + P +V   L      +++ G  H+MAL +
Sbjct: 86  HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145

Query: 391 DGKLYGWGWNKFGQVGAGDNADHCSPAQV-NFPEEQKVAQVACGWRHTLAFTEKKNVFAW 567
           DG+++ WG+N  GQVG+G  A+  +P +V N    ++V  +ACG   ++A  +   V+ W
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGW 205

Query: 568 GRGTSGQLGHGEIVDRNTPVIIDAL 642
           G   +GQLG G   ++ TPV + AL
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRVAAL 230



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 51/160 (31%), Positives = 79/160 (49%), Gaps = 3/160 (1%)
 Frame = +1

Query: 154 PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK 333
           P++++S+   K  +        + V+ +  ++ +G +    LG GD +  LVP K+E L 
Sbjct: 15  PQEIASIR--KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72

Query: 334 DSSTSQIS-GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVA 504
                 +S G   H +  T DG +Y WG N + Q+G G      +P QV  N   +Q V 
Sbjct: 73  GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VV 131

Query: 505 QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
           +VACG  H++A      VFAWG    GQ+G G   ++ TP
Sbjct: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTP 171



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
 Frame = +1

Query: 1   IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
           +R  A   + V  I  G  HT A+T++G +Y WG   YG LG G++N+   P  +  VE 
Sbjct: 225 VRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI-MVEK 283

Query: 181 DKMV-LVACGWRHTITVSSSGSLYTYGWSK 267
           +++V + AC   HT    + G  + Y W +
Sbjct: 284 ERVVEIAACHSAHTSAAKTQGG-HVYMWGQ 312

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score =  129 bits (323), Expect = 1e-29
 Identities = 69/216 (31%), Positives = 122/216 (56%), Gaps = 5/216 (2%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
           R ++  G  +  ++ G+  H    T +G+++ WG   Y  LG G  N   VP  +S+   
Sbjct: 91  RLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLS 150

Query: 181 DKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQI 354
           +K V+ VACG  H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I
Sbjct: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTI 210

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTL 534
           + G    MA+   G++Y WG+N  GQ+G G++ +  +P +V   +  +V +VACG+ HTL
Sbjct: 211 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 535 AFTEKKNVFAWGRGTSGQLGHGEIVDRN--TPVIID 636
             T++  V+AWG  + GQLG G   +++  TPV ++
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE 306



 Score =  121 bits (303), Expect = 2e-27
 Identities = 61/190 (32%), Positives = 109/190 (57%), Gaps = 4/190 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 216
           +A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG   
Sbjct: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMC 216

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 396
            + V  +G +Y +G++  GQLG G+  +   P +V AL+     +++ G+ HT+ LT +G
Sbjct: 217 CMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG 276

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 570
           ++Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A T+  +V+ WG 
Sbjct: 277 QVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336

Query: 571 -RGTSGQLGH 597
            RG S  L H
Sbjct: 337 CRGQSVILPH 346



 Score =  109 bits (273), Expect = 6e-24
 Identities = 63/193 (32%), Positives = 102/193 (52%), Gaps = 3/193 (1%)
 Frame = +1

Query: 73  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WRHTITVSSSGSLY 249
           T + +I+  G    G LGLGD      P ++ S+ G K+  ++ G   H +  ++ G ++
Sbjct: 62  TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121

Query: 250 TYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
           T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTSDG+++ WG+N  
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 427 GQVGAGDNADHCSPAQVNFPEEQKVA-QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           GQVG+G   +   P +V    + KV   +ACG    +A  +   V+ WG   +GQLG G 
Sbjct: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN 241

Query: 604 IVDRNTPVIIDAL 642
             ++ TP  + AL
Sbjct: 242 SGNQPTPCRVAAL 254



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 1/129 (0%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           V  IA G     AV + G++Y WG+   G LGLG+  ++  P +V++++G ++  VACG+
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 266

Query: 211 RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-T 387
            HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT A  T
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326

Query: 388 SDGKLYGWG 414
             G +Y WG
Sbjct: 327 QGGHVYMWG 335



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 1/89 (1%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
           R  A +GI V+ +A G  HT  +T++G +Y WG   YG LG G+++++  P  V +VE D
Sbjct: 250 RVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV-TVEKD 308

Query: 184 KMV-LVACGWRHTITVSSSGSLYTYGWSK 267
           +++ + AC   HT    + G  + Y W +
Sbjct: 309 RIIEIAACHSTHTSAAKTQGG-HVYMWGQ 336

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score =  129 bits (323), Expect = 1e-29
 Identities = 69/216 (31%), Positives = 122/216 (56%), Gaps = 5/216 (2%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG 180
           R ++  G  +  ++ G+  H    T +G+++ WG   Y  LG G  N   VP  +S+   
Sbjct: 91  RLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLS 150

Query: 181 DKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQI 354
           +K V+ VACG  H++ ++S G ++ +G++  GQ+G G   +  +P +V   L++     I
Sbjct: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTI 210

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTL 534
           + G    MA+   G++Y WG+N  GQ+G G++ +  +P +V   +  +V +VACG+ HTL
Sbjct: 211 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 535 AFTEKKNVFAWGRGTSGQLGHGEIVDRN--TPVIID 636
             T++  V+AWG  + GQLG G   +++  TPV ++
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE 306



 Score =  121 bits (303), Expect = 2e-27
 Identities = 61/190 (32%), Positives = 109/190 (57%), Gaps = 4/190 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRH 216
           +A G+ H+  +T DG+++ WG+   G +G G   ++ +P +V+    +K+V+ +ACG   
Sbjct: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMC 216

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 396
            + V  +G +Y +G++  GQLG G+  +   P +V AL+     +++ G+ HT+ LT +G
Sbjct: 217 CMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG 276

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT-LAFTEKKNVFAWG- 570
           ++Y WG N +GQ+G G+ ++   P  V   +++ +   AC   HT  A T+  +V+ WG 
Sbjct: 277 QVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336

Query: 571 -RGTSGQLGH 597
            RG S  L H
Sbjct: 337 CRGQSVILPH 346



 Score =  109 bits (273), Expect = 6e-24
 Identities = 63/193 (32%), Positives = 102/193 (52%), Gaps = 3/193 (1%)
 Frame = +1

Query: 73  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WRHTITVSSSGSLY 249
           T + +I+  G    G LGLGD      P ++ S+ G K+  ++ G   H +  ++ G ++
Sbjct: 62  TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121

Query: 250 TYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
           T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTSDG+++ WG+N  
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 427 GQVGAGDNADHCSPAQVNFPEEQKVA-QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           GQVG+G   +   P +V    + KV   +ACG    +A  +   V+ WG   +GQLG G 
Sbjct: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN 241

Query: 604 IVDRNTPVIIDAL 642
             ++ TP  + AL
Sbjct: 242 SGNQPTPCRVAAL 254



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 1/129 (0%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           V  IA G     AV + G++Y WG+   G LGLG+  ++  P +V++++G ++  VACG+
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 266

Query: 211 RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-T 387
            HT+ ++  G +Y +G + YGQLG G+  +   P  V   KD      +    HT A  T
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326

Query: 388 SDGKLYGWG 414
             G +Y WG
Sbjct: 327 QGGHVYMWG 335



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 1/89 (1%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
           R  A +GI V+ +A G  HT  +T++G +Y WG   YG LG G+++++  P  V +VE D
Sbjct: 250 RVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV-TVEKD 308

Query: 184 KMV-LVACGWRHTITVSSSGSLYTYGWSK 267
           +++ + AC   HT    + G  + Y W +
Sbjct: 309 RIIEIAACHSTHTSAAKTQGG-HVYMWGQ 336

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score =  119 bits (298), Expect = 8e-27
 Identities = 73/237 (30%), Positives = 119/237 (50%), Gaps = 27/237 (11%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 177
           R+    G+ V+ +A+G  A H+  +T +G ++ WG    G LG GD     VP+ + S++
Sbjct: 132 RYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLK 191

Query: 178 GDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TSQI 354
           G+  V  ACG  HT+ ++ +GS+Y +G +K GQLG G+  D  VP   + L +    +++
Sbjct: 192 GEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTD-AVPSPAQILYNGQPITKV 250

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQ 495
           + G   +M +   G LY +G  ++GQ+G   +  + + AQ               F E+ 
Sbjct: 251 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKT 310

Query: 496 K-----------VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVII 633
           K           V  +ACG  H+L    +K VF+WG G  G+LGH E  D   P ++
Sbjct: 311 KDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLV 367



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 58/165 (35%), Positives = 92/165 (55%), Gaps = 3/165 (1%)
 Frame = +1

Query: 112 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGH 285
           Y NLG     + + P +   + G ++  VA G    H++ ++  G L+++G +  GQLGH
Sbjct: 120 YRNLG----QNLWGPHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGH 175

Query: 286 GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC- 462
           GD +   VP  +E+LK       + G  HT+ALT +G +Y +G NK GQ+G G+  D   
Sbjct: 176 GDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVP 235

Query: 463 SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 597
           SPAQ+ +   Q + +VACG   ++    K N++++G    GQLGH
Sbjct: 236 SPAQILY-NGQPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGH 279



 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 59/214 (27%), Positives = 99/214 (46%), Gaps = 27/214 (12%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           E+ +G      A G  HT A+TE+G +Y +G  + G LGLG++ D           G  +
Sbjct: 188 ESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQPI 247

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG------------DFEDHLVPHK----V 321
             VACG   ++ +   G+LY++G  +YGQLGH             +++  L+  +    +
Sbjct: 248 TKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFI 307

Query: 322 EALKDSS--------TSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 477
           E  KD             I+ G  H++ L S  +++ WG+  +G++G  +  D   P  V
Sbjct: 308 EKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLV 367

Query: 478 ---NFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 570
              +FP  +  AQ+  G   + A +E   +F WG
Sbjct: 368 KLFDFP-GRGAAQIYAGATCSFAVSEMGGLFFWG 400



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
 Frame = +1

Query: 16  FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 195
           F G     I AGA  + AV+E G ++ WG           R+    P+ V  + G K+  
Sbjct: 372 FPGRGAAQIYAGATCSFAVSEMGGLFFWGATNTS------RDSTMYPKAVQDLCGWKVRS 425

Query: 196 VACGWRHTITVSSSGSLYTYGWSK-YGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGW 366
           +ACG + +I V++  S  ++G S  +G+LG+GD   +      +V+ L    + Q+  G 
Sbjct: 426 LACG-KSSIIVAADESTISWGPSPTFGELGYGDNKAKSSTTAQEVKTLDGIYSDQVIMGN 484

Query: 367 RHTMALTSD 393
            HT+ +  D
Sbjct: 485 SHTLVVARD 493



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 19/50 (38%), Positives = 31/50 (62%)
 Frame = +1

Query: 493 QKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
           + VA  +C   H+L  T +  +++WGR   GQLGHG+I   + P +I++L
Sbjct: 142 RSVASGSCA-AHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESL 190

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score =  119 bits (297), Expect = 1e-26
 Identities = 69/223 (30%), Positives = 117/223 (52%), Gaps = 6/223 (2%)
 Frame = +1

Query: 1   IRHEAFEGI----SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKV 165
           ++H  FE I     +  I  G  H+ A+++ G+++ WG   +G LG+G +      P+ V
Sbjct: 126 MKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIV 185

Query: 166 SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST 345
             + G  +  ++ G  H++ +S SG++Y++G ++ GQLG G  E    P  +E L +   
Sbjct: 186 EHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKV 245

Query: 346 SQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWR 525
             ++ G  H+  LT DG L+ +G  K GQ+G     +   P  V      +V Q+ACG  
Sbjct: 246 EFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW 305

Query: 526 HTLAF-TEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 651
           HTLA+ ++   VF++G G  GQLG+G   D+  P+ +   S +
Sbjct: 306 HTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSE 348



 Score =  112 bits (279), Expect = 1e-24
 Identities = 66/211 (31%), Positives = 105/211 (49%), Gaps = 12/211 (5%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           E   G+ +  I+AG  H+ A++  G+IY WG    G LGLG    +  P  +  ++  K+
Sbjct: 186 EHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKV 245

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
             VACG  H+  ++  G L+T+G  K+GQLGH   ++ L P  V  L     +QI+ G  
Sbjct: 246 EFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW 305

Query: 370 HTMALTSD-GKLYGWGWNKFGQVGAGDNADHCSPAQV-----------NFPEEQKVAQVA 513
           HT+A  SD GK++ +G  K GQ+G G   D   P  V           +   E+++  +A
Sbjct: 306 HTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIA 365

Query: 514 CGWRHTLAFTEKKNVFAWGRGTSGQLGHGEI 606
            G +  L + +K+N +   + T   L  G +
Sbjct: 366 GGNQSILLWIKKENSYVNLKRTIPTLNEGTV 396



 Score =  110 bits (276), Expect = 3e-24
 Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 1/209 (0%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLV 198
           + + +  +  GAEH   ++ DG  +      Y N  +  ++ RF     S ++  K++ +
Sbjct: 95  KNMKIHSVDQGAEHMLILSSDGKPF-----EYDNYSM--KHLRFE----SILQEKKIIQI 143

Query: 199 ACGWRHTITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKVEALKDSSTSQISGGWRHT 375
            CG  H++ +S  G L+ +G + +GQLG G  F     P  VE L     +QIS G  H+
Sbjct: 144 TCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHS 203

Query: 376 MALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 555
           MAL+  G +Y WG N+ GQ+G G       P+ +   + QKV  VACG  H+   T+   
Sbjct: 204 MALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGL 263

Query: 556 VFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
           +F +G G  GQLGH    +   P ++  L
Sbjct: 264 LFTFGAGKHGQLGHNSTQNELRPCLVAEL 292

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score =  118 bits (295), Expect = 2e-26
 Identities = 62/186 (33%), Positives = 103/186 (55%), Gaps = 1/186 (0%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 219
           ++ G EHTA VT +  +Y +G   +G LGLG +     P  + +++ +K+ L ACG  HT
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 99

Query: 220 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST-SQISGGWRHTMALTSDG 396
           +  + +G +Y  G +  GQLG GD +D    H++     + T  Q+S G   + ALT DG
Sbjct: 100 LVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDG 159

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           KL+ WG N  GQ+G  D ++ C P +V     + ++ ++CG+ H+   T    ++ +G  
Sbjct: 160 KLFMWGDNSEGQIGLEDKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYTFGEP 217

Query: 577 TSGQLG 594
            +G+LG
Sbjct: 218 ENGKLG 223



 Score =  107 bits (268), Expect = 2e-23
 Identities = 63/194 (32%), Positives = 110/194 (56%), Gaps = 3/194 (1%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 207
           ++K ++AGA  +AA+TEDG ++ WG    G +GL D+++  +P +V+   G  +  ++CG
Sbjct: 141 TIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVT--VGKPISWISCG 198

Query: 208 WRHTITVSSSGSLYTYGWSKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWRHTMA 381
           + H+  V+  G LYT+G  + G+LG  +    +H  P +V  + +    Q++ G  HT+ 
Sbjct: 199 YYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPE-RVIQVACGGGHTVV 257

Query: 382 LTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNV 558
           LT +  +Y +G  +FGQ+G G      S P  +   ++QK+  ++CG  HT   TE   +
Sbjct: 258 LT-EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLL 316

Query: 559 FAWGRGTSGQLGHG 600
           + +G G  G+LG G
Sbjct: 317 YTFGDGRHGKLGLG 330



 Score =  105 bits (262), Expect = 1e-22
 Identities = 75/216 (34%), Positives = 115/216 (53%), Gaps = 5/216 (2%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR-FVPEKVSSVEGDK 186
           +A +   VK+ A G  HT   T+ G +Y  G    G LGLGD +DR    + V     D 
Sbjct: 82  KALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADT 141

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
           +  ++ G   +  ++  G L+ +G +  GQ+G  D  +  +PH+V   K    S IS G+
Sbjct: 142 IKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGK--PISWISCGY 199

Query: 367 RHTMALTSDGKLYGWGWNKFGQVGAGDN--ADHCSPAQV-NFPEEQKVAQVACGWRHTLA 537
            H+  +T DG+LY +G  + G++G  +    +H SP +V   PE  +V QVACG  HT+ 
Sbjct: 200 YHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPE--RVIQVACGGGHTVV 257

Query: 538 FTEKKNVFAWGRGTSGQLGHGE-IVDRNTPVIIDAL 642
            TEK  V+A+G G  GQLG G  + + + P II+ +
Sbjct: 258 LTEKV-VYAFGLGQFGQLGLGTFLFETSEPKIIERI 292



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 61/186 (32%), Positives = 94/186 (50%), Gaps = 6/186 (3%)
 Frame = +1

Query: 1   IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR---NDRFVPEKVSS 171
           I HE   G  +  I+ G  H+A VT DG++Y +G    G LGL +    N R  P++V  
Sbjct: 182 IPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHR-SPQRVLG 240

Query: 172 VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF-EDHLVPHKVEALKDSSTS 348
           +  ++++ VACG  HT+ ++    +Y +G  ++GQLG G F  +   P  +E +KD    
Sbjct: 241 IP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKIC 298

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAG--DNADHCSPAQVNFPEEQKVAQVACGW 522
            IS G  HT  +T  G LY +G  + G++G G  +  +   P   +      V  +ACG 
Sbjct: 299 HISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGG 358

Query: 523 RHTLAF 540
            H L F
Sbjct: 359 CHMLVF 364



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 1/182 (0%)
 Frame = +1

Query: 52  AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 231
           AE  + V + G ++ +G  ++            +P K    + D  + ++CG  HT  V+
Sbjct: 2   AESESLVPDTGAVFTFGKTKFAEN---------IPSKFW-FKNDIPICLSCGDEHTAIVT 51

Query: 232 SSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGW 411
            +  LY +G + +GQLG G     + P  ++ALK       + G  HT+  T  G +Y  
Sbjct: 52  GNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAA 111

Query: 412 GWNKFGQVGAGDNADHCSPAQ-VNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQ 588
           G N  GQ+G GD  D  +  Q V F     + Q++ G   + A TE   +F WG  + GQ
Sbjct: 112 GGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQ 171

Query: 589 LG 594
           +G
Sbjct: 172 IG 173



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 44/132 (33%), Positives = 67/132 (50%)
 Frame = +1

Query: 226 VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 405
           V  +G+++T+G +K+ +          +P K    K+     +S G  HT  +T + KLY
Sbjct: 8   VPDTGAVFTFGKTKFAEN---------IPSKFW-FKNDIPICLSCGDEHTAIVTGNNKLY 57

Query: 406 GWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSG 585
            +G N +GQ+G G  A    P  +   + +KV   ACG  HTL  T+   V+A G    G
Sbjct: 58  MFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEG 117

Query: 586 QLGHGEIVDRNT 621
           QLG G+  DR+T
Sbjct: 118 QLGLGDTDDRDT 129



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 2/94 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWR 213
           I+ G  HTA +TE G +Y +G GR+G LGLG  N  ++F P   S+     + L+ACG  
Sbjct: 300 ISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGC 359

Query: 214 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPH 315
           H         +  +   + G +    FED   P+
Sbjct: 360 H---------MLVFATPRLGTIDEPKFEDVYEPY 384



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 16/48 (33%), Positives = 22/48 (45%)
 Frame = +1

Query: 508 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 651
           ++CG  HT   T    ++ +G    GQLG G       P  I AL P+
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPE 87

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score =  115 bits (287), Expect = 1e-25
 Identities = 70/237 (29%), Positives = 115/237 (48%), Gaps = 27/237 (11%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 177
           R+    G+ V+ + +G  A H+  +T +G ++ WG    G LG GD      P  + ++ 
Sbjct: 139 RYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALS 198

Query: 178 GDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TSQI 354
            + +VL ACG  HT+ ++ +GS++ +G +K GQLG G+  D  VP   + + +    +++
Sbjct: 199 HEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTD-AVPSPAQIMYNGQPITKM 257

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQ 495
           + G   +M +   G LY +G  ++GQ+G   +    + AQ               F E+ 
Sbjct: 258 ACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 317

Query: 496 K-----------VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVII 633
           K           V  VACG  HTL    +K VF+WG G  G+LGH E  D   P ++
Sbjct: 318 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 374



 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 58/214 (27%), Positives = 100/214 (46%), Gaps = 27/214 (12%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           EA    ++ + A G  HT A+T+ G ++ +G  + G LGLG++ D           G  +
Sbjct: 195 EALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 254

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG------------DFEDHLVPHKV---- 321
             +ACG   ++ +   G+LY++G  +YGQLGH             +++  LVP +V    
Sbjct: 255 TKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFI 314

Query: 322 EALKDSS--------TSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 477
           E  KD             ++ G  HT+ L S  +++ WG+  +G++G  +  D   P  V
Sbjct: 315 EKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 374

Query: 478 ---NFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 570
              +FP  +   Q+  G+  + A +E   +F WG
Sbjct: 375 KLFDFP-GRGATQIYAGYTCSFAVSEVGGLFFWG 407



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 54/165 (32%), Positives = 91/165 (55%), Gaps = 3/165 (1%)
 Frame = +1

Query: 112 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGH 285
           Y NLG     + + P +   + G ++  V  G    H++ +++ G L+++G ++ GQLGH
Sbjct: 127 YRNLG----QNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGH 182

Query: 286 GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC- 462
           GD +    P  +EAL   +    + G  HT+ALT  G ++ +G NK GQ+G G+  D   
Sbjct: 183 GDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVP 242

Query: 463 SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 597
           SPAQ+ +   Q + ++ACG   ++    K N++++G    GQLGH
Sbjct: 243 SPAQIMY-NGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGH 286



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 2/103 (1%)
 Frame = +1

Query: 310 PHKVEALKDSSTSQISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 483
           PH+   L       +  G    H++ +T++GKL+ WG N+ GQ+G GD     +P  +  
Sbjct: 137 PHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEA 196

Query: 484 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 612
              + +   ACG  HTLA T+  +VFA+G    GQLG G   D
Sbjct: 197 LSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTD 239



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 42/173 (24%), Positives = 69/173 (39%), Gaps = 50/173 (28%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE--------------- 159
           + V+ +A GA HT  +     ++ WG+G YG LG  ++ D  VP                
Sbjct: 328 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQI 387

Query: 160 --------KVSSVEG----------------DKMVLVACGWR--------HTITVSSSGS 243
                    VS V G                 K V   CGWR         +I V++  S
Sbjct: 388 YAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 447

Query: 244 LYTYGWSK-YGQLGHGDF--EDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 393
             ++G S  +G+LG+GD   +      +V+ L    + Q++ G+ H++ +  D
Sbjct: 448 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 500



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 17/40 (42%), Positives = 25/40 (62%)
 Frame = +1

Query: 526 HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
           H+L  T +  +++WGR   GQLGHG+      P +I+ALS
Sbjct: 159 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALS 198

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score =  114 bits (285), Expect = 3e-25
 Identities = 61/186 (32%), Positives = 102/186 (54%), Gaps = 1/186 (0%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 219
           ++ G EH+A VT +  +Y +G   +G LGLG ++    P  V +++ +K+ L ACG  HT
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 220 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEAL-KDSSTSQISGGWRHTMALTSDG 396
           +  +  G++Y  G +  GQLG GD E+    H +     +    Q+S G   + ALT DG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           +L+ WG N  GQ+G  + ++ C P QV     + V+ ++CG+ H+   T    ++ +G  
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEP 217

Query: 577 TSGQLG 594
            +G+LG
Sbjct: 218 ENGKLG 223



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 59/193 (30%), Positives = 107/193 (55%), Gaps = 3/193 (1%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           +K ++AG+  +AA+TEDG ++ WG    G +GL + ++  VP++V+   G  +  ++CG+
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGY 199

Query: 211 RHTITVSSSGSLYTYGWSKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            H+  V++ G LY +G  + G+LG  +    +H  P  V  + +    Q++ G  HT+ L
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGGEHTVVL 258

Query: 385 TSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 561
           T +  +Y +G  +FGQ+G G      S P  +    +Q ++ ++CG  HT   T+   ++
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMY 317

Query: 562 AWGRGTSGQLGHG 600
            +G G  G+LG G
Sbjct: 318 TFGDGRHGKLGLG 330



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 71/214 (33%), Positives = 113/214 (52%), Gaps = 5/214 (2%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD-K 186
           +A +   VK+ A G  HT   TE G++Y  G    G LGLGD  +R     +S    + K
Sbjct: 82  KALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK 141

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
           +  ++ G   +  ++  G L+ +G +  GQ+G  +  +  VP +V   K    S IS G+
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGK--PVSWISCGY 199

Query: 367 RHTMALTSDGKLYGWGWNKFGQVGAGDN--ADHCSPAQVN-FPEEQKVAQVACGWRHTLA 537
            H+  +T+DG+LY +G  + G++G  +    +H +P  V+  PE  KV QVACG  HT+ 
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE--KVIQVACGGEHTVV 257

Query: 538 FTEKKNVFAWGRGTSGQLGHGE-IVDRNTPVIID 636
            TE   V+ +G G  GQLG G  + + + P +I+
Sbjct: 258 LTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIE 290



 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 1/141 (0%)
 Frame = +1

Query: 175 EGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI 354
           + D  V ++CG  H+  V+ +  LY +G + +GQLG G       P  V+ALK       
Sbjct: 33  KNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLA 92

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVN-FPEEQKVAQVACGWRHT 531
           + G  HT+  T  G +Y  G N  GQ+G GD  +  +   ++ F  E K+ Q++ G   +
Sbjct: 93  ACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTS 152

Query: 532 LAFTEKKNVFAWGRGTSGQLG 594
            A TE   +F WG  + GQ+G
Sbjct: 153 AALTEDGRLFMWGDNSEGQIG 173



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 46/129 (35%), Positives = 66/129 (51%)
 Frame = +1

Query: 235 SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 414
           SG+++T+G SK+ +   G F            K+     +S G  H+  +T + KLY +G
Sbjct: 11  SGAVFTFGKSKFAENNPGKFW----------FKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60

Query: 415 WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
            N +GQ+G G  +    P  V   + +KV   ACG  HTL  TE  NV+A G    GQLG
Sbjct: 61  SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120

Query: 595 HGEIVDRNT 621
            G+  +RNT
Sbjct: 121 LGDTEERNT 129



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 32/97 (32%), Positives = 57/97 (58%), Gaps = 3/97 (3%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVLVACG 207
           V  +A G EHT  +TE+  +Y +G G++G LGLG    +   P+ + ++    +  ++CG
Sbjct: 245 VIQVACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCG 303

Query: 208 WRHTITVSSSGSLYTYGWSKYGQLGHG--DFEDHLVP 312
             HT  ++  G +YT+G  ++G+LG G  +F +H +P
Sbjct: 304 ENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIP 340



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 2/71 (2%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVA 201
           ++  I+ G  HTA +T+ G +Y +G GR+G LGLG  N  + F+P   S+     + LVA
Sbjct: 296 TISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVA 355

Query: 202 CGWRHTITVSS 234
           CG  H +  ++
Sbjct: 356 CGGCHMVVFAA 366



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 21/90 (23%), Positives = 39/90 (43%)
 Frame = +1

Query: 382 LTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 561
           +   G ++ +G +KF +          +P +  F  +  V  ++CG  H+   T    ++
Sbjct: 8   MPDSGAVFTFGKSKFAEN---------NPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLY 57

Query: 562 AWGRGTSGQLGHGEIVDRNTPVIIDALSPD 651
            +G    GQLG G     + P  + AL P+
Sbjct: 58  MFGSNNWGQLGLGSKSAISKPTCVKALKPE 87

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score =  112 bits (280), Expect = 1e-24
 Identities = 60/186 (32%), Positives = 98/186 (52%), Gaps = 1/186 (0%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 219
           ++ G EHTA VT +  +Y +G   +G LGLG ++    P  V +++ +K+   ACG  HT
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHT 99

Query: 220 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEAL-KDSSTSQISGGWRHTMALTSDG 396
           +  +  G +Y  G +  GQLG GD E+    H +          Q+S G   + ALT DG
Sbjct: 100 LVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDG 159

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           +L+ WG N  GQ+G  +  + C P QV     + ++ ++CG+ H+   T +  ++ +G  
Sbjct: 160 ELFMWGDNSEGQIGLENVTNVCVPQQVTV--GKPISWISCGYYHSAFVTTEGQLYTFGEP 217

Query: 577 TSGQLG 594
             G+LG
Sbjct: 218 ECGKLG 223



 Score =  106 bits (264), Expect = 7e-23
 Identities = 62/193 (32%), Positives = 110/193 (56%), Gaps = 3/193 (1%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           +K ++AG+  +AA+TEDG+++ WG    G +GL +  +  VP++V+   G  +  ++CG+
Sbjct: 142 IKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVT--VGKPISWISCGY 199

Query: 211 RHTITVSSSGSLYTYGWSKYGQLGHGD--FEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            H+  V++ G LYT+G  + G+LG  +    +H +P  V  +      Q++ G  HT+ L
Sbjct: 200 YHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGI-PGKVVQVACGGGHTVVL 258

Query: 385 TSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVF 561
           T +  +Y +G  +FGQ+G G      S P  +   ++QK++ +ACG  HT   T+   ++
Sbjct: 259 T-EKAVYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMY 317

Query: 562 AWGRGTSGQLGHG 600
            +G G  G+LG G
Sbjct: 318 TFGDGRHGKLGLG 330



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 68/201 (33%), Positives = 101/201 (50%), Gaps = 4/201 (1%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD-K 186
           +A +   VK  A G  HT   TE G +Y  G    G LGLGD  +R     +S      K
Sbjct: 82  KALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRK 141

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
           +  ++ G   +  ++  G L+ +G +  GQ+G  +  +  VP +V   K    S IS G+
Sbjct: 142 IKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVTVGK--PISWISCGY 199

Query: 367 RHTMALTSDGKLYGWGWNKFGQVGAGDN--ADHCSPAQV-NFPEEQKVAQVACGWRHTLA 537
            H+  +T++G+LY +G  + G++G  +    +H  P  V   P   KV QVACG  HT+ 
Sbjct: 200 YHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIP--GKVVQVACGGGHTVV 257

Query: 538 FTEKKNVFAWGRGTSGQLGHG 600
            TEK  V+ +G G  GQLG G
Sbjct: 258 LTEKA-VYTFGLGQFGQLGLG 277



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 46/139 (33%), Positives = 71/139 (51%), Gaps = 1/139 (0%)
 Frame = +1

Query: 181 DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISG 360
           D    ++CG  HT  V+ +  LY +G + +GQLG G       P  V+ALK       + 
Sbjct: 35  DVPTFLSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAAC 94

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVN-FPEEQKVAQVACGWRHTLA 537
           G  HT+  T  GK+Y  G N  GQ+G GD  +  +   ++ F  ++K+ Q++ G   + A
Sbjct: 95  GRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAA 154

Query: 538 FTEKKNVFAWGRGTSGQLG 594
            TE   +F WG  + GQ+G
Sbjct: 155 LTEDGELFMWGDNSEGQIG 173



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 44/129 (34%), Positives = 66/129 (51%)
 Frame = +1

Query: 235 SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 414
           SG+++T+G +++ +          +P K     D  T  +S G  HT  +T + KLY +G
Sbjct: 11  SGAVFTFGKTQFAEN---------IPSKFWFRNDVPTF-LSCGDEHTAVVTGNNKLYMFG 60

Query: 415 WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
            N +GQ+G G  +    P  V   + +KV   ACG  HTL  TE   V+A G    GQLG
Sbjct: 61  SNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLG 120

Query: 595 HGEIVDRNT 621
            G+  +R+T
Sbjct: 121 LGDTEERST 129



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 27/70 (38%), Positives = 42/70 (60%), Gaps = 2/70 (2%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVAC 204
           +  IA G  HTA +T+ G +Y +G GR+G LGLG  N  ++F+P   S+     + LV+C
Sbjct: 297 ISFIACGENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSC 356

Query: 205 GWRHTITVSS 234
           G  HT+  ++
Sbjct: 357 GGCHTLVFAT 366



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 15/48 (31%), Positives = 23/48 (47%)
 Frame = +1

Query: 508 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 651
           ++CG  HT   T    ++ +G    GQLG G     + P  + AL P+
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPE 87

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score =  112 bits (279), Expect = 1e-24
 Identities = 67/236 (28%), Positives = 109/236 (46%), Gaps = 26/236 (11%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 177
           R+     + V  + +G  A H+  +T +G ++ WG    G LG GD      P+ +  + 
Sbjct: 114 RYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLG 173

Query: 178 GDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS 357
            + +V  ACG  HT+ ++ +G++YT+G +K GQLG G+  D ++             +++
Sbjct: 174 EEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVA 233

Query: 358 GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQK 498
            G   +M +   G LY +G  ++GQ+G   +    + AQ               F E+ K
Sbjct: 234 CGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTK 293

Query: 499 VAQ-----------VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVII 633
             Q           VACG  HTL    +K VF+WG G  G+LGH E  D   P ++
Sbjct: 294 DGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 349



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 27/223 (12%)
 Frame = +1

Query: 16  FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRND------------RFVPE 159
           + G  +  +A GAE +  V   G++Y +G   YG LG                    +P 
Sbjct: 224 YNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPR 283

Query: 160 KVS---SVEGDKMVL---------VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDH 303
           +V+       D  VL         VACG  HT+ + S   ++++G+  YG+LGH + +D 
Sbjct: 284 RVAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 343

Query: 304 LVPHKVEA--LKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 477
           +VP  V+         +QI  G++ + AL+  G L+ WG      V          P  V
Sbjct: 344 MVPRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLFFWG------VTNTSRESTMYPKAV 397

Query: 478 NFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG-TSGQLGHGE 603
                 K+  +ACG + ++      +  +WG   T G+LG+G+
Sbjct: 398 QDLCGWKIRSLACG-KSSIIVAADDSTISWGPSPTFGELGYGD 439



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 15/42 (35%), Positives = 24/42 (57%)
 Frame = +1

Query: 526 HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSPD 651
           H+L  T +  +++WGR   GQLGHG+      P +I+ L  +
Sbjct: 134 HSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEE 175

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score =  111 bits (278), Expect = 2e-24
 Identities = 69/237 (29%), Positives = 113/237 (47%), Gaps = 27/237 (11%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 177
           R+    G+ V+ + +G  A H+  +T +G ++ WG    G LG GD      P  +  + 
Sbjct: 141 RYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 200

Query: 178 GDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TSQI 354
            + +V  ACG  HT+ ++ +GS++ +G +K GQLG G+  D  VP   + + +    +++
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTD-AVPSPAQIMYNGQPITKM 259

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ-------------VNFPEEQ 495
           + G   +M +   G LY +G  ++GQ+G   +    + AQ               F E+ 
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319

Query: 496 K-----------VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVII 633
           K           V  VACG  HTL    +K VF+WG G  G+LGH E  D   P ++
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 61/214 (28%), Positives = 103/214 (48%), Gaps = 30/214 (14%)
 Frame = +1

Query: 19  EGISVKMI---AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           EG+S ++I   A G  HT A+TE G ++ +G  + G LGLG++ D           G  +
Sbjct: 197 EGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG------------DFEDHLVPHKV---- 321
             +ACG   ++ +   G+LY++G  +YGQLGH             +++  LVP +V    
Sbjct: 257 TKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFI 316

Query: 322 EALKDSS--------TSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 477
           E  KD             ++ G  HT+ L S  +++ WG+  +G++G  +  D   P  V
Sbjct: 317 EKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376

Query: 478 ---NFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 570
              +FP  +  +Q+  G+  + A +E   +F WG
Sbjct: 377 KLFDFP-GRGASQIYAGYTCSFAVSEVGGLFFWG 409



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 53/165 (32%), Positives = 89/165 (53%), Gaps = 3/165 (1%)
 Frame = +1

Query: 112 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGH 285
           Y NLG     + + P +   + G ++  V  G    H++ +++ G L+++G ++ GQLGH
Sbjct: 129 YRNLG----QNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGH 184

Query: 286 GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC- 462
           GD +    P  +E L        + G  HT+ALT  G ++ +G NK GQ+G G+  D   
Sbjct: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVP 244

Query: 463 SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGH 597
           SPAQ+ +   Q + ++ACG   ++    K N++++G    GQLGH
Sbjct: 245 SPAQIMY-NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGH 288



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 37/103 (35%), Positives = 53/103 (51%), Gaps = 2/103 (1%)
 Frame = +1

Query: 310 PHKVEALKDSSTSQISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 483
           PH+   L       +  G    H++ +T++GKL+ WG N+ GQ+G GD     +P  +  
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198

Query: 484 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 612
              + +   ACG  HTLA TE  +VFA+G    GQLG G   D
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTD 241



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 42/173 (24%), Positives = 69/173 (39%), Gaps = 50/173 (28%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE--------------- 159
           + V+ +A GA HT  +     ++ WG+G YG LG  ++ D  VP                
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389

Query: 160 --------KVSSVEG----------------DKMVLVACGWR--------HTITVSSSGS 243
                    VS V G                 K V   CGWR         +I V++  S
Sbjct: 390 YAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 449

Query: 244 LYTYGWSK-YGQLGHGDF--EDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 393
             ++G S  +G+LG+GD   +      +V+ L    + Q++ G+ H++ +  D
Sbjct: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 16/40 (40%), Positives = 24/40 (60%)
 Frame = +1

Query: 526 HTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALS 645
           H+L  T +  +++WGR   GQLGHG+      P +I+ LS
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 200

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in|
            mitosis A-related kinase 8) (NimA-related protein kinase
            8)
          Length = 698

 Score =  110 bits (275), Expect = 4e-24
 Identities = 70/228 (30%), Positives = 111/228 (48%), Gaps = 15/228 (6%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            EA  G  +  +A GA H  A++ DG+++ WG G  G LGLG R     P++V    G + 
Sbjct: 444  EALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEA 503

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLG--HGDFEDHLVPHKV--EALKDSSTSQ-- 351
              V CG   ++ ++S G +   G +++ +LG  H   ++  VP++   EAL  +      
Sbjct: 504  QRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAP 563

Query: 352  --------ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ 507
                    +  G  H+ A+T+ G  Y +G N+ GQ+G        +P +V   E  K+  
Sbjct: 564  LDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVM 623

Query: 508  VACGWRHTLAFTEKKNVFAWGRGTSGQLG-HGEIVDRNTPVIIDALSP 648
            VACG   T+A   +  V++WG+GT G+LG   E      PV +D   P
Sbjct: 624  VACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHP 671



 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 63/213 (29%), Positives = 98/213 (46%), Gaps = 18/213 (8%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E   G+++K +A G   TA +T+ G I  +G G  G LG G+  D   P  V ++ G +M
Sbjct: 392  EGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEM 451

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
            V VACG  H + +S+ G L+ +G    G+LG G  E H  P +V         ++  G  
Sbjct: 452  VQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGID 511

Query: 370  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP------------------EEQ 495
             +M LTS G++   G N+F ++G     DH S  +   P                  +++
Sbjct: 512  SSMILTSPGRVLACGSNRFNKLG----LDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQE 567

Query: 496  KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
             +  V  G  H+ A T   + + +G    GQLG
Sbjct: 568  PLLCVDLGTAHSAAITASGDCYTFGSNQHGQLG 600



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 7/195 (3%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGW-------GWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           V  +AAG    A VT  G +  W       G G      +     +FV   +    G  +
Sbjct: 340 VVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQSGVTI 399

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
             VACG   T  ++  G + T+G    G LGHG+  D   P  VEAL      Q++ G  
Sbjct: 400 KHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGAS 459

Query: 370 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 549
           H +AL++DG+L+ WG    G++G G    H  P QV     Q+  +V CG   ++  T  
Sbjct: 460 HVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSP 519

Query: 550 KNVFAWGRGTSGQLG 594
             V A G     +LG
Sbjct: 520 GRVLACGSNRFNKLG 534



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 52/187 (27%), Positives = 71/187 (37%), Gaps = 8/187 (4%)
 Frame = +1

Query: 88  IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 267
           +Y WG G    L L   N              ++V VA G      V+ SG L  +    
Sbjct: 320 VYAWGGGLSSPLRLPMLNT-------------EVVQVAAGRTQKAGVTRSGRLILWEAPP 366

Query: 268 YGQLGHGDF--------EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 423
            G  G G          +   V   +E     +   ++ G   T  LT  G +  +G   
Sbjct: 367 LGA-GGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGS 425

Query: 424 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
            G +G G+  D   P  V      ++ QVACG  H LA +    +FAWGRG  G+LG G 
Sbjct: 426 NGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGT 485

Query: 604 IVDRNTP 624
               N P
Sbjct: 486 RESHNCP 492



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
 Frame = +1

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ------- 507
           Q++ G      +T  G+L  W   +   +GAG       P  V  P+ Q V++       
Sbjct: 342 QVAAGRTQKAGVTRSGRLILW---EAPPLGAGGGT--LLPGAVELPQPQFVSRFLEGQSG 396

Query: 508 -----VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
                VACG   T   T++  +  +G G++G LGHG + D + P I++AL
Sbjct: 397 VTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEAL 446



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 25/75 (33%), Positives = 36/75 (48%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD 183
           R +  EGI + M+A G   T AV  +G++Y WG G  G LG  D  D  +P  V   E  
Sbjct: 612 RVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRD-EDAGLPRPVQLDETH 670

Query: 184 KMVLVACGWRHTITV 228
             ++ +    H  T+
Sbjct: 671 PYMVTSVSCCHGNTL 685

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score =  105 bits (262), Expect = 1e-22
 Identities = 74/220 (33%), Positives = 107/220 (48%), Gaps = 19/220 (8%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLG-----LGDRNDR------FVPEKVSS 171
           + V  +A+G +H   +T DGD+Y  G G  G LG       +R  R       VP+ V  
Sbjct: 172 VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVML 231

Query: 172 VEGDKMVLVA-----CGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKD 336
                   V      CG   T  +S  G +Y +G S Y QLG    E   +P  + + K+
Sbjct: 232 KSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKN 291

Query: 337 SSTSQI--SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQ 507
           S+ S +  SGG  HT+ + S+GK Y  G  ++G++G G+ A+  S P  ++      V+ 
Sbjct: 292 STKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS--RLPAVSS 349

Query: 508 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPV 627
           VACG     A T+   VFAWG GT+ QLG G+  D  +PV
Sbjct: 350 VACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 51/173 (29%), Positives = 87/173 (50%), Gaps = 5/173 (2%)
 Frame = +1

Query: 49  GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTI 222
           GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +      V    G  HT+
Sbjct: 248 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 223 TVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 399
            + S G  Y+ G ++YG+LG G+  E+  +P  +  L   + S ++ G     A+T DG+
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVTKDGR 365

Query: 400 LYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVAQVACGWRHTLAFTEKK 552
           ++ WG     Q+G G + D  SP ++     E + V  V+ G +HT+   + K
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDK 418



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 62/226 (27%), Positives = 98/226 (43%), Gaps = 22/226 (9%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVA 201
           V  ++AG  HTAA+T+DG ++ WG  R  N  +G         VP +V       +V VA
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVA 178

Query: 202 CGWRHTITVSSSGSLYTYGWSKYGQL-----------GHGDFEDHLVPHKVEALKDSSTS 348
            G  H + +++ G LYT G  + GQL           G    E  LVP  V      S  
Sbjct: 179 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 238

Query: 349 QIS-----GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQV- 510
            +       G   T A++ +G +YG+G + + Q+G         P  +   +    + V 
Sbjct: 239 HVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVG 298

Query: 511 -ACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE-IVDRNTPVIIDAL 642
            + G  HT+    +   ++ GR   G+LG GE   +++ P +I  L
Sbjct: 299 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL 344



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/131 (29%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
 Frame = +1

Query: 214 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKD--SSTSQISGGWRHTMALT 387
           H    +  G + T G    GQLG G+   +++  K  AL        Q   G  HT+ L+
Sbjct: 27  HRSHSTEPGLVLTLGQGDVGQLGLGE---NVMERKKPALVSIPEDVVQAEAGGMHTVCLS 83

Query: 388 SDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAW 567
             G++Y +G N  G +G   + +           ++KV QV+ G  HT A T+   VF W
Sbjct: 84  KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLW 143

Query: 568 G--RGTSGQLG 594
           G  R  +G +G
Sbjct: 144 GSFRDNNGVIG 154



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV--SSVEGDKMVLVA 201
           +V  +A GA    AVT+DG ++ WG G    LG G   D + P ++    +E   ++ V+
Sbjct: 346 AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405

Query: 202 CGWRHTI 222
            G +HT+
Sbjct: 406 SGGQHTV 412

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in|
            mitosis A-related kinase 8) (NimA-related protein kinase
            8) (NIMA-related kinase 12a)
          Length = 692

 Score =  105 bits (262), Expect = 1e-22
 Identities = 69/228 (30%), Positives = 106/228 (46%), Gaps = 15/228 (6%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            EA  G  +  +A GA H  A++ + +++ WG G  G LGLG R     P++V    G + 
Sbjct: 438  EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEA 497

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLG--HGDFEDHLVPHKV--EALK-------- 333
              V CG   ++ ++  G     G +++ +LG  H    +  VPH+   EAL         
Sbjct: 498  QRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAP 557

Query: 334  --DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ 507
                    I  G  H+ A+T+ G  Y +G N+ GQ+G        +P +V   E  K+A 
Sbjct: 558  LDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAM 617

Query: 508  VACGWRHTLAFTEKKNVFAWGRGTSGQLG-HGEIVDRNTPVIIDALSP 648
            VACG   T+A   +  V++WG+G  G+LG   E      PV +D   P
Sbjct: 618  VACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHP 665



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 61/213 (28%), Positives = 93/213 (43%), Gaps = 18/213 (8%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            E   G+++K +A G   TA +T+ G I  +G G  G LG G   D   P  V ++ G +M
Sbjct: 386  EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
            V VACG  H + +S+   L+ +G    G+LG G  E H  P +V         ++  G  
Sbjct: 446  VQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGID 505

Query: 370  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ------------------ 495
             +M LT  G+    G N+F ++G     DH S  +   P +Q                  
Sbjct: 506  SSMILTVPGQALACGSNRFNKLG----LDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQE 561

Query: 496  KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
             +  +  G  H+ A T   + + +G    GQLG
Sbjct: 562  PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG 594



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 57/195 (29%), Positives = 83/195 (42%), Gaps = 7/195 (3%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGW-------GWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
           V  +AAG    A VT  G +  W       G G      +     +F+   +    G  +
Sbjct: 334 VVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTI 393

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 369
             VACG   T  ++  G + T+G    G LGHG   D   P  VEAL      Q++ G  
Sbjct: 394 KHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGAS 453

Query: 370 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 549
           H +AL+++ +L+ WG    G++G G    H  P QV  P  Q+  +V CG   ++  T  
Sbjct: 454 HVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVP 513

Query: 550 KNVFAWGRGTSGQLG 594
               A G     +LG
Sbjct: 514 GQALACGSNRFNKLG 528



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 51/187 (27%), Positives = 73/187 (39%), Gaps = 8/187 (4%)
 Frame = +1

Query: 88  IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 267
           +Y WG G    L L   N              ++V VA G      V+ SG L  +    
Sbjct: 314 VYAWGGGLGTPLRLPMLNT-------------EVVQVAAGRTQKAGVTRSGRLILWEAPP 360

Query: 268 YGQLGHGDF--------EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 423
            G  G G          +   +   +E     +   ++ G   T  LT  G +  +G   
Sbjct: 361 LGA-GGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGS 419

Query: 424 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
            G +G G   D   P  V      ++ QVACG  H LA + ++ +FAWGRG SG+LG G 
Sbjct: 420 NGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGT 479

Query: 604 IVDRNTP 624
               + P
Sbjct: 480 RESHSCP 486



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 12/110 (10%)
 Frame = +1

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ------- 507
           Q++ G      +T  G+L  W   +   +GAG  +    P  V  P+ Q +++       
Sbjct: 336 QVAAGRTQKAGVTRSGRLILW---EAPPLGAGGGS--LLPGAVEQPQPQFISRFLEGQSG 390

Query: 508 -----VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
                VACG   T   T++  +  +G G++G LGHG + D + P I++AL
Sbjct: 391 VTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEAL 440

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score =  105 bits (261), Expect = 2e-22
 Identities = 63/190 (33%), Positives = 95/190 (50%), Gaps = 4/190 (2%)
 Frame = +1

Query: 16   FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL 195
            + G   + IA GAEH   ++  G +  WG  R+G  G+G     F    +  V+GD   +
Sbjct: 773  YPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHS---FRIANLHQVDGDWPAI 829

Query: 196  --VACGWRHTITVSSSGSLYTYGWSKYGQLGHG--DFEDHLVPHKVEALKDSSTSQISGG 363
              +ACG  H+  + S GSL+T+GW  +GQLGHG  +  + LVP +V  L     +QI+ G
Sbjct: 830  EKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGL-ICKVTQIACG 888

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
              HT+ LT  G++   G   +GQ+G  D+               +V  +A  + H++  T
Sbjct: 889  RAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICIT 948

Query: 544  EKKNVFAWGR 573
            E   VF WGR
Sbjct: 949  EDNRVFEWGR 958



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 63/239 (26%), Positives = 104/239 (43%), Gaps = 40/239 (16%)
 Frame = +1

Query: 28   SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRND--RFVPEKVSSVEGDKMVLVA 201
            +++ IA G  H+A +  DG ++ +GWG +G LG G RN+  + VP +V+ +   K+  +A
Sbjct: 828  AIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLIC-KVTQIA 886

Query: 202  CGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMA 381
            CG  HT+ ++ +G +   G   YGQ+G  D    +       L       I+  + H++ 
Sbjct: 887  CGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSIC 946

Query: 382  LTSDGKLYGWGWN------------KFGQVGAGDNADHCSPA----------QVNFPEE- 492
            +T D +++ WG N            K       +  D  SP+           +N P E 
Sbjct: 947  ITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEI 1006

Query: 493  ---------------QKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
                             +  VACG  H+   T +  ++ WG+G   QLGHG   +R  P
Sbjct: 1007 PREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEP 1065



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 50/147 (34%), Positives = 79/147 (53%), Gaps = 2/147 (1%)
 Frame = +1

Query: 160  KVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDS 339
            +V    G +   +ACG  H + +SSSG L  +G +++GQ G G        H+V+     
Sbjct: 769  RVLEYPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDG-DWP 827

Query: 340  STSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG--DNADHCSPAQVNFPEEQKVAQVA 513
            +  +I+ G  H+  + SDG L+ +GW  +GQ+G G  +N++   P +VN     KV Q+A
Sbjct: 828  AIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVN-GLICKVTQIA 886

Query: 514  CGWRHTLAFTEKKNVFAWGRGTSGQLG 594
            CG  HT+  T+   V   G G+ GQ+G
Sbjct: 887  CGRAHTVVLTDTGRVLVCGSGSYGQMG 913



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 5/112 (4%)
 Frame = +1

Query: 136  RNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPH 315
            R D  + E    ++G+ +V VACG  H+  ++S G+LYT+G     QLGHG+  + + PH
Sbjct: 1008 REDLGLREVKHFLDGN-IVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPH 1066

Query: 316  KVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGA-----GDNAD 456
            +V     +    +S G  HT+A T DG ++ WG N FGQ G      G++AD
Sbjct: 1067 QVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGNSAD 1118



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 57/229 (24%), Positives = 92/229 (40%), Gaps = 41/229 (17%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR---FVPEKVSSVEGDKMVLVA 201
            V  IA G  HT  +T+ G +   G G YG +G+ D   +   F P  +  +   ++  +A
Sbjct: 882  VTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPL---RVRDIA 938

Query: 202  CGWRHTITVSSSGSLYTYG------------WSKYGQLGHGDFEDHLVP----------- 312
              + H+I ++    ++ +G              K       + ED   P           
Sbjct: 939  THYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRV 998

Query: 313  ---------------HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGD 447
                            +V+   D +   ++ G  H+  +TS+G LY WG     Q+G G+
Sbjct: 999  NLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGN 1058

Query: 448  NADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
              +   P QV  P   K   V+ G  HT+A T+  +VFAWG+   GQ G
Sbjct: 1059 KNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCG 1107



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 31/85 (36%), Positives = 49/85 (57%)
 Frame = +1

Query: 28   SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG 207
            ++  +A G  H+A +T +G +Y WG G    LG G++N+R  P +V    G K V V+ G
Sbjct: 1023 NIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLG 1082

Query: 208  WRHTITVSSSGSLYTYGWSKYGQLG 282
              HTI  +  GS++ +G + +GQ G
Sbjct: 1083 NNHTIASTDDGSVFAWGKNDFGQCG 1107



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 29/83 (34%), Positives = 46/83 (55%)
 Frame = +1

Query: 352  ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT 531
            I+ G  H + L+S G+L  WG N+FGQ G G +    +  QV+  +   + ++ACG  H+
Sbjct: 781  IACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVD-GDWPAIEKIACGQFHS 839

Query: 532  LAFTEKKNVFAWGRGTSGQLGHG 600
                   +++ +G G  GQLGHG
Sbjct: 840  AFICSDGSLWTFGWGVWGQLGHG 862



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
 Frame = +1

Query: 7    HEAFEGISVKMI--AAGAEHTAAVTEDGDIYGWGWGRYGNLGL 129
            H+ FE    K +  + G  HT A T+DG ++ WG   +G  G+
Sbjct: 1066 HQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCGV 1108

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
            (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score =  103 bits (256), Expect = 6e-22
 Identities = 62/201 (30%), Positives = 97/201 (48%), Gaps = 14/201 (6%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
            V  ++ G  H  A+T    +Y WG G YG LGL   +D + P+KV    G  +V V CG 
Sbjct: 464  VDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGS 523

Query: 211  RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------------Q 351
              +  ++ +G +   G +++ +LG   +   ++ H+       +TS              
Sbjct: 524  DGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRS 583

Query: 352  ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRH 528
            IS G  HT A+   G+L  +G NK GQ+G GD   H     +  P   ++V +V+CG   
Sbjct: 584  ISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEF 643

Query: 529  TLAFTEKKNVFAWGRGTSGQL 591
            T A T   ++FAWG G +G+L
Sbjct: 644  TTAATADNHIFAWGNGGNGRL 664



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 60/198 (30%), Positives = 89/198 (44%), Gaps = 7/198 (3%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
           G   + + AG  H A VT + ++Y W     G   +G LG GDR     P+ V  ++G  
Sbjct: 350 GWRARQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKS 409

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF--EDHLVPHKVEALKDSSTSQISG 360
           +  V+CG   T+ ++  G LY++G   YG LG       + L P  V+   +    Q+S 
Sbjct: 410 VQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSC 469

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G  H MALT    +Y WG  ++G++G     D  SP +V       +  V CG   +   
Sbjct: 470 GDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLL 529

Query: 541 TEKKNVFAWGRGTSGQLG 594
           T    V A G     +LG
Sbjct: 530 TLTGKVLACGLNEHNKLG 547



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 59/182 (32%), Positives = 91/182 (50%), Gaps = 8/182 (4%)
 Frame = +1

Query: 73  TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC-GWRHTITVSSSGSLY 249
           +   ++Y WG G+              P+K+   +G       C G  H   V+    LY
Sbjct: 326 SRSSEVYVWGGGKT------------TPQKLDVFKGGWRARQVCAGDAHFAVVTVEKELY 373

Query: 250 TY----GWSK-YGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 414
           T+    G SK +GQLGHGD   +  P  VE L+  S  ++S G   T+ +T +G+LY +G
Sbjct: 374 TWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFG 433

Query: 415 WNKFGQVGAGDNA--DHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQ 588
            + +G +G   +A  +   P  V+F   + V QV+CG  H +A T  K+V++WG G  G+
Sbjct: 434 SDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSWGCGEYGR 493

Query: 589 LG 594
           LG
Sbjct: 494 LG 495



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 55/213 (25%), Positives = 99/213 (46%), Gaps = 15/213 (7%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR--NDRFVPEKVSSVEGD 183
            E  +G SV+ ++ G++ T  +T++G +Y +G   YG LG+     ++   P  V     +
Sbjct: 403  EKLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNE 462

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
             +  V+CG  H + ++ S S+Y++G  +YG+LG    +D   P KVE  +      +  G
Sbjct: 463  PVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCG 522

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGDNA----DHCSPAQVNFPEE---------QKVA 504
               +  LT  GK+   G N+  ++G         +H +  +V +             K+ 
Sbjct: 523  SDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIR 582

Query: 505  QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
             ++ G  HT A  E+  +  +G    GQLG G+
Sbjct: 583  SISPGRTHTAAIDERGRLLTFGSNKCGQLGVGD 615



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 51/201 (25%), Positives = 85/201 (42%), Gaps = 21/201 (10%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD------RNDRF--VPEKV 165
            E   G+ +  +  G++ +  +T  G +   G   +  LGL         ++ F  VP   
Sbjct: 509  EVQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTT 568

Query: 166  S-----SVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA- 327
            S      +   K+  ++ G  HT  +   G L T+G +K GQLG GD+  HL  + +   
Sbjct: 569  SLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGP 628

Query: 328  LKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN-----ADHCS--PAQVNFP 486
            L      ++S G   T A T+D  ++ WG    G++    N     +D C+  P  + F 
Sbjct: 629  LGGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPI-FG 687

Query: 487  EEQKVAQVACGWRHTLAFTEK 549
                V  ++C   HT+   EK
Sbjct: 688  SLHHVTDLSCRGWHTILIVEK 708



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 16/54 (29%), Positives = 23/54 (42%), Gaps = 5/54 (9%)
 Frame = +1

Query: 496 KVAQVACGWRHTLAFTEKKNVFAW-----GRGTSGQLGHGEIVDRNTPVIIDAL 642
           +  QV  G  H    T +K ++ W     G    GQLGHG+      P  ++ L
Sbjct: 352 RARQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKL 405

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score =  103 bits (256), Expect = 6e-22
 Identities = 75/212 (35%), Positives = 106/212 (50%), Gaps = 17/212 (8%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLG-----LGDRNDR------FVPEKVS-SVEGD 183
           IA+G +H   +T DGD+Y  G G  G LG       +R  R       VP+ +    +G 
Sbjct: 183 IASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGS 242

Query: 184 KMVL---VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI 354
             V    V CG   T  VS  G +Y +G S Y QLG  + +    P  + + K+S+ S I
Sbjct: 243 GRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWI 302

Query: 355 --SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRH 528
             SGG  HT+ + S+GK Y  G  ++G++G G+NA+  S      P+  K+  VA G   
Sbjct: 303 GFSGGQHHTVCVDSEGKAYSLGRAEYGRLGLGENAEEQS-EPTPIPDLPKINSVASGASV 361

Query: 529 TLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
           + A +    VFAWG GT+ QLG GE  D  +P
Sbjct: 362 SYAVSTDGCVFAWGMGTNLQLGTGEEEDVWSP 393



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 50/177 (28%), Positives = 91/177 (51%), Gaps = 5/177 (2%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWR 213
           +  GA  T AV+++G +YG+G   Y  LG  +    + P+ ++S +      +    G  
Sbjct: 250 VFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQH 309

Query: 214 HTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 390
           HT+ V S G  Y+ G ++YG+LG G+  E+   P  +  L     + ++ G   + A+++
Sbjct: 310 HTVCVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDLP--KINSVASGASVSYAVST 367

Query: 391 DGKLYGWGWNKFGQVGAGDNADHCSPAQV--NFPEEQKVAQVACGWRHTLAFTEKKN 555
           DG ++ WG     Q+G G+  D  SP Q+     E+++V  V+ G +HT+    K++
Sbjct: 368 DGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQHTVLLVRKRS 424



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 61/185 (32%), Positives = 89/185 (48%), Gaps = 6/185 (3%)
 Frame = +1

Query: 58  HTAAVTEDGDIYGWGWGRYGNLGLG-DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSS 234
           H +  T  G +   G G  G LGLG D  +R  P  V+  E   +V  A G  HT+ + +
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLTED--IVQAAAGGMHTVCLGA 90

Query: 235 SGSLYTYGWSKYGQLGHGDFED--HLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYG 408
           SGS+YT+G +  G LG    E+   + P KVE  +     Q+S G  HT ALT DG+++ 
Sbjct: 91  SGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAE--KVVQVSAGDSHTAALTEDGRVFV 148

Query: 409 WG--WNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGT 579
           +G   +  G +G  +       P QV       V ++A G  H +  T   +++  G G 
Sbjct: 149 FGSFRDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVLLTVDGDLYTSGCGE 206

Query: 580 SGQLG 594
            GQLG
Sbjct: 207 QGQLG 211



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 59/212 (27%), Positives = 91/212 (42%), Gaps = 21/212 (9%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVA 201
           V  ++AG  HTAA+TEDG ++ +G  R  N  +G         VP +V       ++ +A
Sbjct: 127 VVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIA 184

Query: 202 CGWRHTITVSSSGSLYTYGWSKYGQL-----------GHGDFEDHLVPHKVEALKDSS-- 342
            G  H + ++  G LYT G  + GQL           G    E  LVP  +      S  
Sbjct: 185 SGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGSGR 244

Query: 343 --TSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ--VNFPEEQKV-AQ 507
                +  G   T A++ +G +YG+G + + Q+G   N   C   Q   +F    K    
Sbjct: 245 VHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGT-KNTQACYAPQNLTSFKNSTKSWIG 303

Query: 508 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
            + G  HT+    +   ++ GR   G+LG GE
Sbjct: 304 FSGGQHHTVCVDSEGKAYSLGRAEYGRLGLGE 335



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 53/204 (25%), Positives = 83/204 (40%), Gaps = 20/204 (9%)
 Frame = +1

Query: 43  AAGAEHTAAVTEDGDIYGWGWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRH 216
           AAG  HT  +   G IY +G    G LG    +      P KV   E  K+V V+ G  H
Sbjct: 79  AAGGMHTVCLGASGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAE--KVVQVSAGDSH 136

Query: 217 TITVSSSGSLYTYG--WSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALT 387
           T  ++  G ++ +G      G +G  +  +  +VP +V+   ++   +I+ G  H + LT
Sbjct: 137 TAALTEDGRVFVFGSFRDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVLLT 194

Query: 388 SDGKLYGWGWNKFGQVGAGDN---------------ADHCSPAQVNFPEEQKVAQVACGW 522
            DG LY  G  + GQ+G                      C   +           V CG 
Sbjct: 195 VDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGSGRVHFQDVFCGA 254

Query: 523 RHTLAFTEKKNVFAWGRGTSGQLG 594
             T A +++ +V+ +G     QLG
Sbjct: 255 YFTFAVSQEGHVYGFGLSNYHQLG 278



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 21/66 (31%), Positives = 40/66 (60%), Gaps = 2/66 (3%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS--VEGDKMVLVAC 204
           +  +A+GA  + AV+ DG ++ WG G    LG G+  D + PE+++   +E  +++ V+ 
Sbjct: 352 INSVASGASVSYAVSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSS 411

Query: 205 GWRHTI 222
           G +HT+
Sbjct: 412 GGQHTV 417

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
            (NimA-related protein kinase 9) (Never in mitosis
            A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
            8) (Nek8)
          Length = 979

 Score =  102 bits (254), Expect = 1e-21
 Identities = 59/201 (29%), Positives = 98/201 (48%), Gaps = 14/201 (6%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
            V+ ++ G  H   +T + ++Y WG G YG LGL    D + P+KV   +   +V V CG 
Sbjct: 482  VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGC 541

Query: 211  RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------------Q 351
              T  ++ SG +   G +++ +LG       ++ H+       +TS              
Sbjct: 542  DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 352  ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRH 528
            I+ G  HT A+   G+L  +G NK GQ+G G+         +  P   ++V +V+CG   
Sbjct: 602  IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEF 661

Query: 529  TLAFTEKKNVFAWGRGTSGQL 591
            T+A T+  ++FAWG G +G+L
Sbjct: 662  TIAATDDNHIFAWGNGGNGRL 682



 Score =  101 bits (251), Expect = 2e-21
 Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 7/198 (3%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
           G S + + AG  H A VT + ++Y W     G   +G LG GD+     P+ V  ++G  
Sbjct: 368 GCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKA 427

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE--DHLVPHKVEALKDSSTSQISG 360
           +  V+CG   T+ V+  G LY +G   YG +G       + L P ++     +   Q+S 
Sbjct: 428 IHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSC 487

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G  H + LT + ++Y WG  ++G++G     D+ +P +V+ P+   +  V CG   T   
Sbjct: 488 GDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 547

Query: 541 TEKKNVFAWGRGTSGQLG 594
           T+   V A G     +LG
Sbjct: 548 TQSGKVLACGLNEFNKLG 565



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 61/192 (31%), Positives = 91/192 (47%), Gaps = 8/192 (4%)
 Frame = +1

Query: 85  DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE-GDKMVLVACGWRHTITVSSSGSLYTY-- 255
           ++Y WG G+              P+K+  ++ G     V  G  H   V+    LYT+  
Sbjct: 348 EVYVWGGGKS------------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVN 395

Query: 256 ---GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
              G   +GQLGHGD   +  P  VE L+  +  Q+S G   T+ +T +G+LY +G + +
Sbjct: 396 MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYY 455

Query: 427 GQVGAGDNA--DHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHG 600
           G +G    A  +   P Q+NF     V QV+CG  H +  T  K V++WG G  G+LG  
Sbjct: 456 GCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLD 515

Query: 601 EIVDRNTPVIID 636
              D  TP  +D
Sbjct: 516 SEEDYYTPQKVD 527



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 58/217 (26%), Positives = 99/217 (45%), Gaps = 15/217 (6%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV--PEKVSSVEGD 183
            E  +G ++  ++ G + T  VT++G +Y +G   YG +G+       V  P +++    +
Sbjct: 421  EKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN 480

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
             +  V+CG  H + ++ +  +Y++G  +YG+LG    ED+  P KV+  K      +  G
Sbjct: 481  PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG 540

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGD--------NADHCSPAQVNFPEEQ-----KVA 504
               T  LT  GK+   G N+F ++G            A H  P   +F   +     K+ 
Sbjct: 541  CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 600

Query: 505  QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDR 615
             +A G  HT A  E+  +  +G    GQLG G    R
Sbjct: 601  TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKR 637



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 14/36 (38%), Positives = 19/36 (52%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL 129
           G  V  ++ G E T A T+D  I+ WG G  G L +
Sbjct: 649 GKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score =  101 bits (252), Expect = 2e-21
 Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 7/198 (3%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
           G S + + AG  H A VT + ++Y W     G   +G LG GD+     P+ V  ++G  
Sbjct: 368 GCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKA 427

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE--DHLVPHKVEALKDSSTSQISG 360
           +  V+CG   T+ V+  G LY +G   YG +G       + L P ++     +   Q+S 
Sbjct: 428 IHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSC 487

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G  H + LT + ++Y WG  ++G++G     D+ +P +V+ P+   +  V CG   T   
Sbjct: 488 GDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLL 547

Query: 541 TEKKNVFAWGRGTSGQLG 594
           T+   V A G     +LG
Sbjct: 548 TQSGKVLACGLNEFNKLG 565



 Score =  101 bits (251), Expect = 2e-21
 Identities = 58/201 (28%), Positives = 98/201 (48%), Gaps = 14/201 (6%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
            V+ ++ G  H   +T + ++Y WG G YG LGL    D + P++V   +   +V V CG 
Sbjct: 482  VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGC 541

Query: 211  RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------------Q 351
              T  ++ SG +   G +++ +LG       ++ H+       +TS              
Sbjct: 542  DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 352  ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRH 528
            I+ G  HT A+   G+L  +G NK GQ+G G+         +  P   ++V +V+CG   
Sbjct: 602  IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEF 661

Query: 529  TLAFTEKKNVFAWGRGTSGQL 591
            T+A T+  ++FAWG G +G+L
Sbjct: 662  TIAATDDNHIFAWGNGGNGRL 682



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 60/192 (31%), Positives = 90/192 (46%), Gaps = 8/192 (4%)
 Frame = +1

Query: 85  DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE-GDKMVLVACGWRHTITVSSSGSLYTY-- 255
           ++Y WG G+              P+K+  ++ G     V  G  H   V+    LYT+  
Sbjct: 348 EVYVWGGGKS------------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVN 395

Query: 256 ---GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 426
              G   +GQLGHGD   +  P  VE L+  +  Q+S G   T+ +T +G+LY +G + +
Sbjct: 396 MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYY 455

Query: 427 GQVGAG--DNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHG 600
           G +G       +   P Q+NF     V QV+CG  H +  T  K V++WG G  G+LG  
Sbjct: 456 GCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLD 515

Query: 601 EIVDRNTPVIID 636
              D  TP  +D
Sbjct: 516 SEEDYYTPQRVD 527



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 57/217 (26%), Positives = 100/217 (46%), Gaps = 15/217 (6%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV--PEKVSSVEGD 183
            E  +G ++  ++ G + T  VT++G +Y +G   YG +G+   +   V  P +++    +
Sbjct: 421  EKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSN 480

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
             +  V+CG  H + ++ +  +Y++G  +YG+LG    ED+  P +V+  K      +  G
Sbjct: 481  PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCG 540

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVGAGD--------NADHCSPAQVNFPEEQ-----KVA 504
               T  LT  GK+   G N+F ++G            A H  P   +F   +     K+ 
Sbjct: 541  CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 600

Query: 505  QVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDR 615
             +A G  HT A  E+  +  +G    GQLG G    R
Sbjct: 601  TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKR 637



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 14/36 (38%), Positives = 19/36 (52%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL 129
           G  V  ++ G E T A T+D  I+ WG G  G L +
Sbjct: 649 GKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score =  101 bits (251), Expect = 2e-21
 Identities = 63/188 (33%), Positives = 91/188 (48%), Gaps = 1/188 (0%)
 Frame = +1

Query: 88  IYGWGWGRYGNLGLGDRNDRFVPEKVSSV-EGDKMVLVACGWRHTITVSSSGSLYTYGWS 264
           ++ WG   YG LGLG + D F+P+++S   +   +  V  G  H+  V+  G L+  G +
Sbjct: 17  LFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLN 76

Query: 265 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 444
           K GQLG G  E+ L     + L+     Q++ GW  T+ LT  G++   G N FGQ+G  
Sbjct: 77  KDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVP 136

Query: 445 DNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
                C   Q      +KV  VA G RH LA T   +VF WG G +   G      +N P
Sbjct: 137 HGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGTGLASS-GRRLCPGQNLP 195

Query: 625 VIIDALSP 648
           + + A  P
Sbjct: 196 LFLTAKEP 203



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 61/199 (30%), Positives = 97/199 (48%), Gaps = 8/199 (4%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVA 201
           G  ++ +A G + T  +TE G +   G   +G LG+     + V  +      +K+V VA
Sbjct: 100 GCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVA 159

Query: 202 CGWRHTITVSSSGSLYTYGW---SKYGQLGHGD----FEDHLVPHKVEALKDSSTSQISG 360
            G RH +  +++GS++ +G    S   +L  G     F     P +V  L++S+      
Sbjct: 160 AGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVA 219

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGA-GDNADHCSPAQVNFPEEQKVAQVACGWRHTLA 537
           G  H+ +LT  G+LY WG NK GQ+ +           + ++ +++KV  V  GW H +A
Sbjct: 220 GSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVA 279

Query: 538 FTEKKNVFAWGRGTSGQLG 594
            TE   VF WGR   GQLG
Sbjct: 280 KTETGKVFTWGRADYGQLG 298



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 9/196 (4%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           +K +  G  H+A VT+ GD++  G  + G LGLG   +         + G  +  VACGW
Sbjct: 51  IKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGW 110

Query: 211 RHTITVSSSGSLYTYGWSKYGQLG--HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
             TI ++  G + + G + +GQLG  HG     +VP  +E L++     ++ G RH +A 
Sbjct: 111 DFTIMLTEKGQVLSCGSNAFGQLGVPHGP-RKCVVPQAIECLREKVVC-VAAGLRHALAT 168

Query: 385 TSDGKLYGWGW---NKFGQVGAGDN----ADHCSPAQVNFPEEQKVAQVACGWRHTLAFT 543
           T+ G ++ WG    +   ++  G N         P++V   E         G  H+ + T
Sbjct: 169 TATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLT 228

Query: 544 EKKNVFAWGRGTSGQL 591
           +   ++ WGR   GQL
Sbjct: 229 DTGELYVWGRNKHGQL 244



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 65/236 (27%), Positives = 98/236 (41%), Gaps = 30/236 (12%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGN---LGLGDRNDRFV----PEKVSSVEGDKM 189
           V  +AAG  H  A T  G ++ WG G   +   L  G     F+    P +V+ +E    
Sbjct: 155 VVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTA 214

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA--LKDSSTSQISGG 363
           V    G  H+ +++ +G LY +G +K+GQL        L P ++EA   +D   + +  G
Sbjct: 215 VCAVAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPL-PQRIEAHYFQDEKVTAVWSG 273

Query: 364 WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK--------------- 498
           W H +A T  GK++ WG   +GQ+G         P +   P EQ                
Sbjct: 274 WTHLVAKTETGKVFTWGRADYGQLGR-----RLEPPEAQKPVEQDSSLAFQGPQNSVPSP 328

Query: 499 ------VAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDALSP 648
                   +++CG  H LA    K   +WG    G  G G   +  TP  + AL P
Sbjct: 329 LHCLTGATEISCGSEHNLAVIRDK-CCSWGWNEHGMCGDGTESNVWTPTPVQALPP 383



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 55/204 (26%), Positives = 94/204 (46%), Gaps = 26/204 (12%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV----PEKVSS 171
           R    E  +     AG++H+A++T+ G++Y WG  ++G L       R V    P+++ +
Sbjct: 205 RVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA-----SRAVFLPLPQRIEA 259

Query: 172 --VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG------------------D 291
              + +K+  V  GW H +  + +G ++T+G + YGQLG                     
Sbjct: 260 HYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQ 319

Query: 292 FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPA 471
              + VP  +  L  +  ++IS G  H +A+  D K   WGWN+ G  G G  ++  +P 
Sbjct: 320 GPQNSVPSPLHCL--TGATEISCGSEHNLAVIRD-KCCSWGWNEHGMCGDGTESNVWTPT 376

Query: 472 QVNF--PEEQKVAQVACGWRHTLA 537
            V    P   ++  V CG  H+LA
Sbjct: 377 PVQALPPSPSRLLLVGCGAGHSLA 400



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 47/134 (35%), Positives = 68/134 (50%), Gaps = 8/134 (5%)
 Frame = +1

Query: 223 TVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGK 399
           TVS++  L+ +G + YGQLG G  ED  +P ++ +  +      ++GG  H+  +T  G 
Sbjct: 10  TVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGD 69

Query: 400 LYGWGWNKFGQVGAGDNAD-----HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFA 564
           L+  G NK GQ+G G   +      C P +        + QVACGW  T+  TEK  V +
Sbjct: 70  LFVCGLNKDGQLGLGHTEEVLRFTICKPLR-----GCPIRQVACGWDFTIMLTEKGQVLS 124

Query: 565 WGRGTSGQLG--HG 600
            G    GQLG  HG
Sbjct: 125 CGSNAFGQLGVPHG 138

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score =  100 bits (249), Expect = 4e-21
 Identities = 73/218 (33%), Positives = 105/218 (48%), Gaps = 19/218 (8%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLG-----LGDRNDR------FVPE----KV 165
           V  +A+G +H   +T DGD+Y  G G  G LG       +R  R       VP     K 
Sbjct: 174 VVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRLLVPRCVLLKS 233

Query: 166 SSVEGDKMVLVA-CGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS 342
               G      A CG   T  +S  G +Y +G S Y QLG        +P  + + K+S+
Sbjct: 234 RGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNST 293

Query: 343 TSQI--SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEEQKVAQVA 513
            S +  SGG  HT+ + S+GK Y  G  ++G++G G+ A+  S P  ++      V+ VA
Sbjct: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS--RLPVVSSVA 351

Query: 514 CGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPV 627
           CG     A ++   VFAWG GT+ QLG G+  D  +PV
Sbjct: 352 CGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 49/167 (29%), Positives = 84/167 (50%), Gaps = 5/167 (2%)
 Frame = +1

Query: 49  GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTI 222
           GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +      V    G  HT+
Sbjct: 248 GAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 223 TVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 399
            + S G  Y+ G ++YG+LG G+  E+  +P  +  L     S ++ G     A++ DG+
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--VVSSVACGASVGYAVSKDGR 365

Query: 400 LYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRHTL 534
           ++ WG     Q+G G + D  SP ++     E + V  V+ G +HT+
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTV 412



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 65/227 (28%), Positives = 100/227 (44%), Gaps = 23/227 (10%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVA 201
           V  ++AG  HTAA+TEDG ++ WG  R  N  +G         VP +V       +V VA
Sbjct: 121 VVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DAPVVKVA 178

Query: 202 CGWRHTITVSSSGSLYTYGWSKYGQLGHGD--FEDH---------LVPHKVEALKDSST- 345
            G  H + +++ G LYT G  + GQLG     F +          LVP  V  LK   T 
Sbjct: 179 SGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRLLVPRCV-LLKSRGTR 237

Query: 346 -----SQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQV 510
                     G   T A++ +G +YG+G + + Q+G         P  +   +    + V
Sbjct: 238 GRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWV 297

Query: 511 --ACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE-IVDRNTPVIIDAL 642
             + G  HT+    +   ++ GR   G+LG GE   +++ P +I  L
Sbjct: 298 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL 344



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 40/122 (32%), Positives = 57/122 (46%), Gaps = 3/122 (2%)
 Frame = +1

Query: 238 GSLYTYGWSKYGQLGHGDFE-DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 414
           G + T G    GQLG G+   +   P  V  L+D    Q   G  HT+ L+  G++Y +G
Sbjct: 35  GLVLTLGQGDVGQLGLGESVLERKKPALVPLLQD--VVQAEAGGMHTVCLSQSGQVYSFG 92

Query: 415 WNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG--RGTSGQ 588
            N  G +G   + +           ++KV QV+ G  HT A TE   VF WG  R  +G 
Sbjct: 93  CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGV 152

Query: 589 LG 594
           +G
Sbjct: 153 IG 154



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 21/66 (31%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVS--SVEGDKMVLVAC 204
           V  +A GA    AV++DG ++ WG G    LG G   D + P +++   +E   ++ V+ 
Sbjct: 347 VSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSS 406

Query: 205 GWRHTI 222
           G +HT+
Sbjct: 407 GGQHTV 412

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 73/225 (32%), Positives = 107/225 (47%), Gaps = 26/225 (11%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG---------D 183
           V  +A+G +H   +T DGD+Y  G G  G LG        VPE  ++  G          
Sbjct: 174 VVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGR-------VPELFANRGGRQGLERLLVP 226

Query: 184 KMVLVA--------------CGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV 321
           K VL+               CG   T  +S  G +Y +G S Y QLG        +P  +
Sbjct: 227 KCVLLKSRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNL 286

Query: 322 EALKDSSTSQI--SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS-PAQVNFPEE 492
            + K+S+ S +  SGG  HT+ + S+GK Y  G  ++G++G G+ A+  S P  ++    
Sbjct: 287 TSFKNSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS--RL 344

Query: 493 QKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPV 627
             V+ VACG     A ++   VFAWG GT+ QLG G+  D  +PV
Sbjct: 345 PVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 51/173 (29%), Positives = 86/173 (49%), Gaps = 5/173 (2%)
 Frame = +1

Query: 49  GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTI 222
           GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +      V    G  HTI
Sbjct: 248 GAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTI 307

Query: 223 TVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 399
            + S G  Y+ G ++YG+LG G+  E+  +P  +  L     S ++ G     A++ DG+
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--VVSSVACGASVGYAVSKDGR 365

Query: 400 LYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRHTLAFTEKK 552
           ++ WG     Q+G G + D  SP ++     E + V  V+ G +HT+   + K
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDK 418



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 64/226 (28%), Positives = 100/226 (44%), Gaps = 22/226 (9%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVA 201
           V  ++AG  HTAA+TEDG ++ WG  R  N  +G         VP +V       +V VA
Sbjct: 121 VVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DMPVVKVA 178

Query: 202 CGWRHTITVSSSGSLYTYGWSKYGQL-----------GHGDFEDHLVPHKVEALKDSSTS 348
            G  H + +++ G LYT G  + GQL           G    E  LVP  V      S  
Sbjct: 179 SGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVLLKSRGSRG 238

Query: 349 QIS-----GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQV- 510
           ++       G   T A++ +G +YG+G + + Q+G    A    P  +   +    + V 
Sbjct: 239 RVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVG 298

Query: 511 -ACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE-IVDRNTPVIIDAL 642
            + G  HT+    +   ++ GR   G+LG GE   +++ P +I  L
Sbjct: 299 FSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL 344



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 41/130 (31%), Positives = 58/130 (44%), Gaps = 3/130 (2%)
 Frame = +1

Query: 214 HTITVSSSGSLYTYGWSKYGQLGHGDFE-DHLVPHKVEALKDSSTSQISGGWRHTMALTS 390
           H    +  G + T G    GQLG G+   +   P  V  L+D    Q   G  HT+ L  
Sbjct: 27  HRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLLQD--VVQAEAGGMHTVCLNQ 84

Query: 391 DGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 570
            G++Y +G N  G +G   + +           ++KV QV+ G  HT A TE   VF WG
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWG 144

Query: 571 --RGTSGQLG 594
             R  +G +G
Sbjct: 145 SFRDNNGVIG 154



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 21/66 (31%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVS--SVEGDKMVLVAC 204
           V  +A GA    AV++DG ++ WG G    LG G   D + P +++   +E   ++ V+ 
Sbjct: 347 VSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSS 406

Query: 205 GWRHTI 222
           G +HT+
Sbjct: 407 GGQHTV 412

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 54/164 (32%), Positives = 81/164 (49%), Gaps = 1/164 (0%)
 Frame = +1

Query: 88  IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSSSGSLYTYGWS 264
           ++ WG   YG LGLG + D  +P++++     + V  +  G  H+  V+  G L+  G +
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76

Query: 265 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 444
           K GQLG G  ED       ++L      Q++ GW  T+ LT +G++   G N FGQ+G  
Sbjct: 77  KDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVP 136

Query: 445 DNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
                C   Q     ++KV  +A G RH +A T    VF WG G
Sbjct: 137 HGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 9/200 (4%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVA 201
           G  ++ +A G + T  +TE+G +   G   +G LG+     R V  +   +  +K+V +A
Sbjct: 100 GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIA 159

Query: 202 CGWRHTITVSSSGSLYTYGWSKYG---QLGHGD----FEDHLVPHKVEALKDSSTSQISG 360
            G RH +  ++SG ++ +G        +L  G     F     P +V  L++S    +  
Sbjct: 160 AGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLA 219

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP--EEQKVAQVACGWRHTL 534
           G  H+ +LT  G++Y WG NK GQ+ A + A    P ++     + +KV  +  GW H +
Sbjct: 220 GSDHSASLTDAGEVYVWGSNKHGQL-ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLV 278

Query: 535 AFTEKKNVFAWGRGTSGQLG 594
           A TE   +F WGR   GQLG
Sbjct: 279 AQTETGKMFTWGRADYGQLG 298



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 66/204 (32%), Positives = 96/204 (47%), Gaps = 14/204 (6%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRND--RFVPEKVSSVEGDKMVLVA 201
           SV+ I  G  H+A VT+ GD++  G  + G LGLG   D   F P K  S+ G  +  VA
Sbjct: 50  SVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCK--SLFGCPIQQVA 107

Query: 202 CGWRHTITVSSSGSLYTYGWSKYGQLG--HGDFEDHLVPHKVEALKDSSTSQISGGWRHT 375
           CGW  TI ++ +G + + G + +GQLG  HG     +VP  +E  K+     I+ G RH 
Sbjct: 108 CGWDFTIMLTENGQVLSCGSNSFGQLGVPHGP-RRCVVPQAIELHKEKVVC-IAAGLRHA 165

Query: 376 MALTSDGKLYGWGWNKFGQVGAGDNA----------DHCSPAQVNFPEEQKVAQVACGWR 525
           +A T+ G ++ WG    G    G                 P++V   E  K   V  G  
Sbjct: 166 VAATASGIVFQWG---TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSD 222

Query: 526 HTLAFTEKKNVFAWGRGTSGQLGH 597
           H+ + T+   V+ WG    GQL +
Sbjct: 223 HSASLTDAGEVYVWGSNKHGQLAN 246



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 53/199 (26%), Positives = 94/199 (47%), Gaps = 18/199 (9%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS--VE 177
           R    E      + AG++H+A++T+ G++Y WG  ++G L   +     VP+K+ +   +
Sbjct: 205 RVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQ 263

Query: 178 GDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG---------DFEDHLVP--HKVE 324
            +K+  +  GW H +  + +G ++T+G + YGQLG           + +D  +P      
Sbjct: 264 NEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPN 323

Query: 325 ALKDS-----STSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPE 489
           ++  S       +++S G  H +A+   G  Y WGWN+ G  G G  A+  +P  V    
Sbjct: 324 SMPSSPHCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALL 382

Query: 490 EQKVAQVACGWRHTLAFTE 546
                 V CG  H+LA  +
Sbjct: 383 SSSGLLVGCGAGHSLALCQ 401



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 48/128 (37%), Positives = 71/128 (55%), Gaps = 5/128 (3%)
 Frame = +1

Query: 232 SSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGKLYG 408
           ++ +L+ +G + YGQLG G  ED L+P ++ +  K  S  +I+GG  H+  +T  G L+ 
Sbjct: 13  AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72

Query: 409 WGWNKFGQVGAGDNAD--HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTS 582
            G NK GQ+G G   D  + +P +  F     + QVACGW  T+  TE   V + G  + 
Sbjct: 73  CGLNKDGQLGLGHTEDIPYFTPCKSLF--GCPIQQVACGWDFTIMLTENGQVLSCGSNSF 130

Query: 583 GQLG--HG 600
           GQLG  HG
Sbjct: 131 GQLGVPHG 138



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 51/207 (24%), Positives = 80/207 (38%), Gaps = 16/207 (7%)
 Frame = +1

Query: 1   IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLG---------DRNDRFV 153
           I    F+   V  I +G  H  A TE G ++ WG   YG LG           ++ D F+
Sbjct: 257 IEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFL 316

Query: 154 P--EKVSSVEGDKMVL-----VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVP 312
           P     +S+      L     V+CG  H + +   G  Y++GW+++G  G G   +   P
Sbjct: 317 PCSRPPNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGTEANVWAP 375

Query: 313 HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEE 492
             V+AL  SS   +  G  H++AL                +       + SP  +   E 
Sbjct: 376 KPVQALLSSSGLLVGCGAGHSLALCQ--------LPAHPALVQDPKVTYLSPDAIEDTES 427

Query: 493 QKVAQVACGWRHTLAFTEKKNVFAWGR 573
           QK       W+   + T  ++   W R
Sbjct: 428 QKAMDKERNWKERQSETSTQSQSDWSR 454

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 64/218 (29%), Positives = 99/218 (45%), Gaps = 11/218 (5%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS-VEG 180
           R + F+G  V  +A G +H+  +T+ G++Y  GWG  G  GLG  N    P K+   + G
Sbjct: 224 RMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282

Query: 181 DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH-GDFEDHLVPHKVEALKDSSTSQIS 357
             ++ VA      + VS+ G L+ +G S+Y QL    D     VP  +         Q +
Sbjct: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342

Query: 358 GGWRHTMALTSDGKLYGWGWNKFGQVGAGDN-ADHCSPAQV--------NFPEEQKVAQV 510
            G      L  +G ++ WG   +G +G G N  +   P  +         F  E +V+++
Sbjct: 343 CGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399

Query: 511 ACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
            CG  H  A T K  +F WG+   G LG G + D+  P
Sbjct: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 54/185 (29%), Positives = 81/185 (43%), Gaps = 10/185 (5%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLG-LGDRNDRFVPEKVSSVEGDKMVLV 198
           G++V  +A   +   AV+ DG ++GWG   Y  L  + D     VP  +      K+   
Sbjct: 282 GVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 341

Query: 199 ACGWRHTITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKV--------EALKDSSTSQ 351
           ACG      ++  G ++ +G   YG LG G +  +  VP  +        E   +   S+
Sbjct: 342 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398

Query: 352 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT 531
           I  G  H  ALT+ G+L+ WG N  G +G G   D   P +V  P E     VACG  H 
Sbjct: 399 IRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP--VDVACGVDHM 456

Query: 532 LAFTE 546
           +   +
Sbjct: 457 VTLAK 461



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 39/141 (27%), Positives = 66/141 (46%), Gaps = 5/141 (3%)
 Frame = +1

Query: 184 KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV--PHKVEALK--DSSTSQ 351
           +++ V+CG  H++ ++    +++ G + YGQ G    E+ +    H+V  ++  D    Q
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234

Query: 352 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP-EEQKVAQVACGWRH 528
           ++ G  H++ LT  G++Y  GW   GQ G G      SP ++        V QVA     
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294

Query: 529 TLAFTEKKNVFAWGRGTSGQL 591
            LA +    +F WG     QL
Sbjct: 295 CLAVSADGGLFGWGNSEYLQL 315



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 27/71 (38%), Positives = 41/71 (57%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 204
           I V  I  G  H AA+T  G+++ WG    G LG+G   D++ P +V ++ G+  V VAC
Sbjct: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEP-VDVAC 451

Query: 205 GWRHTITVSSS 237
           G  H +T++ S
Sbjct: 452 GVDHMVTLAKS 462



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 13/109 (11%)
 Frame = +1

Query: 307 VPHKVEALKDSSTSQISGGWRHTMALTSD-GKLYGWGWNKFGQVGAGDNADH-------- 459
           VP+++E  +  S++    G+    + T+D  K++G G NK  Q+G   +           
Sbjct: 99  VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158

Query: 460 CSPAQVNFP----EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
             P+ V+ P    +E +V QV+CG  H+L  T+++ VF+ G  + GQ G
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCG 207

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 62/218 (28%), Positives = 99/218 (45%), Gaps = 11/218 (5%)
 Frame = +1

Query: 4   RHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS-VEG 180
           R + F+G  V  +  G +H+  +T+ G++Y  GWG  G  GLG  N    P K+   + G
Sbjct: 221 RMQDFDG-QVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAG 279

Query: 181 DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH-GDFEDHLVPHKVEALKDSSTSQIS 357
             +V VA      + +S+ G ++ +G S+Y QL    D     VP  +         Q++
Sbjct: 280 VTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVA 339

Query: 358 GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA-DHCSPAQV--------NFPEEQKVAQV 510
            G      L ++G ++ WG   +G +G G    +   P  +         F  E +V+Q+
Sbjct: 340 CGGTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQI 396

Query: 511 ACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
            CG  H  A T K  +F WG+   G LG G + D+  P
Sbjct: 397 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 434



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 54/185 (29%), Positives = 82/185 (44%), Gaps = 10/185 (5%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLG-LGDRNDRFVPEKVSSVEGDKMVLV 198
           G++V  +A   +   A++ DG ++GWG   Y  L  + D     VP  +      K+  V
Sbjct: 279 GVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQV 338

Query: 199 ACGWRHTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKV--------EALKDSSTSQ 351
           ACG      +++ G ++ +G   YG LG G    +  +P  +        E   +   SQ
Sbjct: 339 ACGGTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQ 395

Query: 352 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT 531
           I  G  H  ALT+ G+L+ WG N  G +G G   D   P +V  P E     VACG  H 
Sbjct: 396 IRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP--VDVACGVDHM 453

Query: 532 LAFTE 546
           +   +
Sbjct: 454 VTLAK 458



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 43/152 (28%), Positives = 70/152 (46%), Gaps = 5/152 (3%)
 Frame = +1

Query: 151 VPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV--PHKVE 324
           VP  +   +  K++ V+CG  H++ ++    +++ G + +GQ G    ED +    HKV 
Sbjct: 161 VPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVH 220

Query: 325 ALK--DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP-EEQ 495
            ++  D    Q+  G  H++ LT  G++Y  GW   GQ G G      +P+++       
Sbjct: 221 RMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGV 280

Query: 496 KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQL 591
            V QVA      LA +    VF WG     QL
Sbjct: 281 TVVQVATYGDCCLALSADGGVFGWGNSEYLQL 312



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 13/115 (11%)
 Frame = +1

Query: 307 VPHKVEALKDSSTSQISGGWRHTMALTSD-GKLYGWGWNKFGQVGAGDNADHCS------ 465
           VP+++E     S++    G+    + T D  K++G G NK  Q+G   +    +      
Sbjct: 96  VPYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 155

Query: 466 ------PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 612
                 P  ++ P+E KV QV+CG  H+L  T+++ VF+ G  + GQ G   + D
Sbjct: 156 LEPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVED 210



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/71 (36%), Positives = 41/71 (57%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 204
           + V  I  G  H AA+T  G+++ WG    G LG+G   D++ P +V ++ G+  V VAC
Sbjct: 391 VQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEP-VDVAC 448

Query: 205 GWRHTITVSSS 237
           G  H +T++ S
Sbjct: 449 GVDHMVTLAKS 459

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
            (NimA-related protein kinase 8)
          Length = 697

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
 Frame = +1

Query: 10   EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 189
            EA  G  +  ++ GA H  AVT + +++ WG G  G LGL  ++    P++VS     + 
Sbjct: 445  EALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEA 504

Query: 190  VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF-------------EDHLVPHKVEA- 327
              V CG   ++ +S+   +   G +++ +LG                 E HL      A 
Sbjct: 505  QRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAP 564

Query: 328  LKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ 507
            L       I  G  H++A+T  G+ + +G N+ GQ+G         P QV+    Q +  
Sbjct: 565  LNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVS--GLQGITM 622

Query: 508  VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
             ACG   TLA   +  V+ WG+G  G+LG  E
Sbjct: 623  AACGDAFTLAIGAEGEVYTWGKGARGRLGRKE 654



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 6/204 (2%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL------GLGDRNDRFVPEKVSSVEGDKMV 192
           V  ++ G      VT+ G +  W     G+        +     +F+   +    G  + 
Sbjct: 342 VIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIK 401

Query: 193 LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRH 372
            V+CG   T  ++  G + T+G    G LGHG+F D   P  VEAL      Q+S G  H
Sbjct: 402 SVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASH 461

Query: 373 TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKK 552
            +A+T++ +++ WG    G++G      H  P QV+ P + +  +V CG   ++  + + 
Sbjct: 462 VLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQH 521

Query: 553 NVFAWGRGTSGQLGHGEIVDRNTP 624
            + A G     +LG  ++     P
Sbjct: 522 QILACGNNRFNKLGLDKVSGTEEP 545



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 32/107 (29%), Positives = 51/107 (47%), Gaps = 9/107 (8%)
 Frame = +1

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA-----DHCSPAQVN-FPEEQK---V 501
           Q+S G    M +T  G+L  W   +   VG+G+       +   P  ++ F E Q    +
Sbjct: 344 QVSLGRTQKMGVTKSGRLITW---EAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTI 400

Query: 502 AQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
             V+CG   T   T++  +  +G G++G LGHG   D   P I++AL
Sbjct: 401 KSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEAL 447

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 60/209 (28%), Positives = 94/209 (44%), Gaps = 21/209 (10%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACG 207
           +A G +H  A+T  G +Y WG G+   LG      R      P+ ++      ++ V  G
Sbjct: 231 LATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLAL---KNIISVGAG 287

Query: 208 WRHTITVSSSGSLYTYGWSKYGQLGHG--DFEDHLV---PHKVEALKDSSTSQISGGWRH 372
             H+  + + G +Y +G +   Q G    D E+  V   P  V+AL+  +   I+GG  H
Sbjct: 288 SYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHH 347

Query: 373 TMALTSDGKLYGWGWNKFGQVGAGDNA------------DHCSPAQVNFPEEQKVAQVAC 516
           T+AL  DG++  WG +   Q+G  DNA            ++        P    V QV C
Sbjct: 348 TLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVC 407

Query: 517 GWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           G  H LA T    V++WG   + ++G G+
Sbjct: 408 GTHHNLAVTSDGKVYSWGSAENYEVGQGD 436



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 58/203 (28%), Positives = 91/203 (44%), Gaps = 9/203 (4%)
 Frame = +1

Query: 13  AFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 192
           A   + V  +      TAA+T++G  + WG  R  +  LG  + +    + + +   ++ 
Sbjct: 170 ALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEIC 229

Query: 193 LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE----DHLVPHKVEALKDSSTSQISG 360
            +A G  H I ++++G +YT+G  +  QLG    E      L P  + ALK  +   +  
Sbjct: 230 QLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPL-ALK--NIISVGA 286

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVG-----AGDNADHCSPAQVNFPEEQKVAQVACGWR 525
           G  H+ A+ + G++Y WG N   Q G       + A    P  V+  E   V  +  G  
Sbjct: 287 GSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEH 346

Query: 526 HTLAFTEKKNVFAWGRGTSGQLG 594
           HTLA  E   V AWGR    QLG
Sbjct: 347 HTLALLEDGRVLAWGRDDRHQLG 369



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 62/230 (26%), Positives = 99/230 (43%), Gaps = 24/230 (10%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL---------GDRNDRFVPEKV-SSV 174
           + V  +A G  H+AA++ DG +Y WG      LG          GD+ D  + E   S V
Sbjct: 108 VGVVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKV 167

Query: 175 EGD----KMVLVACGWRHTITVSSSGSLYTYGWSKY--GQLGHGDFEDHLVPHKVEALKD 336
           EG     ++  V C    T  ++ +G  +T+G  +   G LG+ D +      +   ++ 
Sbjct: 168 EGALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTA--EPTQMRL 225

Query: 337 SSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQK-VAQVA 513
               Q++ G  H +ALT+ GK+Y WG  +  Q+G               P   K +  V 
Sbjct: 226 PEICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVG 285

Query: 514 CGWRHTLAFTEKKNVFAWGRGTSGQLG-------HGEIVDRNTPVIIDAL 642
            G  H+ A   K  V+AWG   + Q G        G ++ +  P ++DAL
Sbjct: 286 AGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITK--PTLVDAL 333



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 45/159 (28%), Positives = 72/159 (45%), Gaps = 22/159 (13%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWG--RYGNLGLGDRNDRFV---PEKVSSVEGDKMVLVAC 204
           + AG+ H+ A+   G +Y WG    R   + + D  +  V   P  V ++EG  +  +  
Sbjct: 284 VGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITG 343

Query: 205 GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKD---------------- 336
           G  HT+ +   G +  +G     QLG     D+ +P  V  +KD                
Sbjct: 344 GEHHTLALLEDGRVLAWGRDDRHQLG---IPDNALPETV--VKDEKGNNYYLSTPTIIPG 398

Query: 337 -SSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN 450
            ++  Q+  G  H +A+TSDGK+Y WG  +  +VG GDN
Sbjct: 399 LTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDN 437



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 39/122 (31%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG--- 180
           +A EG +VK I  G  HT A+ EDG +  WG      LG+    D  +PE V   E    
Sbjct: 331 DALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGI---PDNALPETVVKDEKGNN 387

Query: 181 ------------DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKV 321
                         ++ V CG  H + V+S G +Y++G ++  ++G GD  ED  VP  V
Sbjct: 388 YYLSTPTIIPGLTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLV 447

Query: 322 EA 327
            +
Sbjct: 448 RS 449

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 53/199 (26%), Positives = 89/199 (44%), Gaps = 14/199 (7%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF----VPEKVSSVEGDK 186
           EG  V  +AA    + A+  +G++Y WG  R     LG   D+      P KV +     
Sbjct: 163 EGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYN 222

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV------PHKVEALKDSSTS 348
           +V +A G  H + +   G ++ +G  +  QLG    E   +      P  +  +K     
Sbjct: 223 IVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVK----- 277

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH----CSPAQVNFPEEQKVAQVAC 516
            I+ G  H  ALT D KL  WG N+FGQ G  ++ +       P ++  P+   +  +A 
Sbjct: 278 YIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAA 337

Query: 517 GWRHTLAFTEKKNVFAWGR 573
           G  H+L  ++  ++++ GR
Sbjct: 338 GEHHSLILSQDGDLYSCGR 356



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 23/222 (10%)
 Frame = +1

Query: 16  FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD---- 183
           F   ++  +A G +H   + E+G ++ WG G+   LG      R V E+      D    
Sbjct: 218 FSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLG------RKVMERFRLKTLDPRPF 271

Query: 184 ---KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG-HGDFEDHLVPHKVE--ALKDSST 345
               +  +A G  H   ++    L ++G +++GQ G   D ED  +  K +  AL D+  
Sbjct: 272 GLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVV 331

Query: 346 -SQISGGWRHTMALTSDGKLYGWGWNKFGQVG-AGDNADHCS-----------PAQVNFP 486
              I+ G  H++ L+ DG LY  G     +VG   DN    +           P      
Sbjct: 332 IRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLN 391

Query: 487 EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 612
              K   VA G  H++A  +    ++WG G +  +G G   D
Sbjct: 392 NVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFED 433



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 53/227 (23%), Positives = 87/227 (38%), Gaps = 37/227 (16%)
 Frame = +1

Query: 43  AAGAEHTAAVTEDGDIYGWGWGRYGNLGL----------------------GDRND-RFV 153
           A G  HT A+ E+ +++ WG    G LG                       GD N+    
Sbjct: 90  AVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELEST 149

Query: 154 PEKVSS------VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHL--- 306
           P K+         EG K+V +A     +  + S+G +Y +G  +  +   G ++D +   
Sbjct: 150 PAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQ 209

Query: 307 -VPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG----AGDNADHCSPA 471
             P KV      +  Q++ G  H + L  +G ++ WG  +  Q+G             P 
Sbjct: 210 KTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPR 269

Query: 472 QVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 612
                  + V  +A G  H  A T+   + +WG    GQ G  E V+
Sbjct: 270 PFGL---RHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVE 313



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 53/213 (24%), Positives = 83/213 (38%), Gaps = 43/213 (20%)
 Frame = +1

Query: 85  DIYGWGWGRYGNLGLG----------DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSS 234
           DI+ WG G    LGLG           R + F+P      +  K++  A G  HT+ +  
Sbjct: 47  DIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPR-----DEAKIISFAVGGMHTLALDE 101

Query: 235 SGSLYTYGWSKYGQLGH-----------------GDFED------HLVPHKV------EA 327
             +++++G +  G LG                   D ED         P K+        
Sbjct: 102 ESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPL 161

Query: 328 LKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC----SPAQVNFPEEQ 495
            +     Q++     + AL S+G++Y WG  +  +   G   D      +P +V    + 
Sbjct: 162 AEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKY 221

Query: 496 KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
            + Q+A G  H L   E+  VFAWG G   QLG
Sbjct: 222 NIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLG 254



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 13/115 (11%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRN------------DRFVPEK 162
           + + ++ IAAG  H+  +++DGD+Y  G      +G+   N             R VP  
Sbjct: 328 DNVVIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLP 387

Query: 163 VSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHL-VPHKVE 324
                  K   VA G  H++ V+ +G  Y++G+ +   +G G FED   VP +++
Sbjct: 388 TKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIK 442



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 22/67 (32%), Positives = 41/67 (61%), Gaps = 3/67 (4%)
 Frame = +1

Query: 34  KMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKV--SSVEGDKMVLVAC 204
           K +AAG+ H+ AV ++G  Y WG+G    +GLG   +D  VP ++  ++ +   ++LV C
Sbjct: 397 KSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGC 456

Query: 205 GWRHTIT 225
           G + +++
Sbjct: 457 GGQFSVS 463



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 27/105 (25%), Positives = 44/105 (41%), Gaps = 11/105 (10%)
 Frame = +1

Query: 313 HKVEALKDSSTSQISGG---WRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 483
           H+ + +  +  S I      ++H         ++ WG     ++G G  A +    +V  
Sbjct: 16  HRAKKMSKTHASHIINAQEDYKHMYLSVQPLDIFCWGTGSMCELGLGPLAKN---KEVKR 72

Query: 484 P--------EEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
           P        +E K+   A G  HTLA  E+ NV++WG    G LG
Sbjct: 73  PRLNPFLPRDEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALG 117

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 33/85 (38%), Positives = 53/85 (62%)
 Frame = +1

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            + V V+CG+ H++ +  +G +YT+G+ ++GQLGHGD      P  V+AL   ST Q++ G
Sbjct: 903  RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAG 961

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVG 438
              HT  L  DG+++ +G    GQ+G
Sbjct: 962  SNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 29/81 (35%), Positives = 45/81 (55%)
 Frame = +1

Query: 40   IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 219
            ++ G  H+  + E+GD+Y +G+G++G LG GD N R  P  V ++ G     V  G  HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965

Query: 220  ITVSSSGSLYTYGWSKYGQLG 282
              +   G ++T+G    GQLG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 23/59 (38%), Positives = 35/59 (59%)
 Frame = +1

Query: 466  PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            P  V F  E +  QV+CG+ H++   E  +V+ +G G  GQLGHG++  R  P ++ AL
Sbjct: 893  PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQAL 951



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 38/136 (27%), Positives = 58/136 (42%), Gaps = 4/136 (2%)
 Frame = +1

Query: 58  HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTIT 225
           H   V EDG I+  G    G  G   ++ R    + P+K+  +EG  +V  AC    +  
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 226 VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 405
           +S  G LY +G           + D      V  LK    +Q++ G  HT  L  +G+++
Sbjct: 615 ISKDGELYMFGKDAI-------YSDS--SSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVW 665

Query: 406 GWGWNKFGQVGAGDNA 453
            +G N  GQ G    A
Sbjct: 666 TFGVNNKGQCGRDTGA 681



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
 Frame = +1

Query: 349  QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGD-NADHCSPAQVNFPEEQKVAQVACGWR 525
            Q+S G+ H++ L  +G +Y +G+ + GQ+G GD N+  C       P      QV  G  
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS--TQVTAGSN 963

Query: 526  HTLAFTEKKNVFAWGRGTSGQLG 594
            HT        VF +G  + GQLG
Sbjct: 964  HTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 44/195 (22%), Positives = 81/195 (41%), Gaps = 9/195 (4%)
 Frame = +1

Query: 37   MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL---GDRNDRFVPEKVSSVEGDKMVLVACG 207
            ++ AG E     T +G IY  G  +Y +LG+   G    ++V   ++  +  K+V  + G
Sbjct: 495  ILGAGREFALMKTANGKIYYTG--KYQSLGIKQGGPSAGKWVELPIT--KSPKIVHFSVG 550

Query: 208  W--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDH----LVPHKVEALKDSSTSQISGGWR 369
                H + V+  GS++  G +  G+ G             P K+  ++       +    
Sbjct: 551  HDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNG 610

Query: 370  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 549
             +  ++ DG+LY +G +        D++   +  + +F     V QVA G  HT    + 
Sbjct: 611  SSSVISKDGELYMFGKDAI----YSDSSSLVTDLKGHF-----VTQVAMGKAHTCVLMKN 661

Query: 550  KNVFAWGRGTSGQLG 594
              V+ +G    GQ G
Sbjct: 662  GEVWTFGVNNKGQCG 676



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 22/91 (24%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK---VSSVEGDKM 189
           EG  V   A     ++ +++DG++Y +G             D    +    V+ ++G  +
Sbjct: 598 EGKIVVYTACNNGSSSVISKDGELYMFG------------KDAIYSDSSSLVTDLKGHFV 645

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLG 282
             VA G  HT  +  +G ++T+G +  GQ G
Sbjct: 646 TQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 61/222 (27%), Positives = 98/222 (44%), Gaps = 14/222 (6%)
 Frame = +1

Query: 10  EAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLG-LGDRN----------DRFVP 156
           +  EG     IA+GA+H   +T  G ++  G    G LG L +R+          D   P
Sbjct: 173 DLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRP 232

Query: 157 EKVSSVEGDKMVLV-ACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF--EDHLVPHKVEA 327
            ++          + A  +   +  S +  ++  G + + QL H     E  L P K E 
Sbjct: 233 TQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTE- 291

Query: 328 LKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQ 507
           LKD     I+GG  HT+ LT+D K    G  ++G++G GD  D      +     +K+  
Sbjct: 292 LKD--IRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVS 349

Query: 508 VACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVII 633
           V CG   + A T    +++WG G + QLG G+  D   P+++
Sbjct: 350 VGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVV 391



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 47/172 (27%), Positives = 71/172 (41%), Gaps = 1/172 (0%)
 Frame = +1

Query: 82  GDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEG-DKMVLVACGWRHTITVSSSGSLYTYG 258
           G++   G G  G LGLG+  D    +++S V G    V ++ G  H + ++ SG +Y++G
Sbjct: 42  GNVLVCGNGDVGQLGLGE--DILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFG 99

Query: 259 WSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 438
            +  G LG    ED                 IS G  H+  L  DG+++ WG  +     
Sbjct: 100 CNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGN 159

Query: 439 AGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
            G   D      ++  E      +A G  H +  T    VF  G    GQLG
Sbjct: 160 MGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLG 211



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 53/217 (24%), Positives = 94/217 (43%), Gaps = 15/217 (6%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGR--YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWR 213
           I+AG  H+A + EDG ++ WG  R  +GN+GL    ++  P  +  +EG     +A G  
Sbjct: 131 ISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTP--IDLMEGTVCCSIASGAD 188

Query: 214 HTITVSSSGSLYTYGWSKYGQL-----------GHGDFEDHLVPHKVEALKDSSTSQI-S 357
           H + ++++G ++T G ++ GQL           G     D L P ++   +      I +
Sbjct: 189 HLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWA 248

Query: 358 GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLA 537
             +   M  +    ++  G N F Q+         +   +   E + +  +A G  HT+ 
Sbjct: 249 TNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIK-TELKDIRHIAGGQHHTVI 307

Query: 538 FTEKKNVFAWGRGTSGQLGHGEIVD-RNTPVIIDALS 645
            T        GR   G+LG G++ D    P I+  L+
Sbjct: 308 LTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT 344



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 39/135 (28%), Positives = 60/135 (44%), Gaps = 5/135 (3%)
 Frame = +1

Query: 238 GSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-QISGGWRHTMALTSDGKLYGWG 414
           G++   G    GQLG G  ED L   ++  +     +  IS G  H + LT  G +Y +G
Sbjct: 42  GNVLVCGNGDVGQLGLG--EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFG 99

Query: 415 WNKFGQVGAGDNAD--HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG--RGTS 582
            N  G +G   + D     P  ++ P   K   ++ G  H+    E   VFAWG  R + 
Sbjct: 100 CNDEGALGRDTSEDGSESKPDLIDLPG--KALCISAGDSHSACLLEDGRVFAWGSFRDSH 157

Query: 583 GQLGHGEIVDRNTPV 627
           G +G     ++ TP+
Sbjct: 158 GNMGLTIDGNKRTPI 172



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 24/63 (38%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS--VEGDKMVLVACGWR 213
           +  G   + AVT DG +Y WG G    LG+GD +D   P  V S   +G  M+L + G +
Sbjct: 350 VGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQ 409

Query: 214 HTI 222
           H I
Sbjct: 410 HAI 412

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 35/95 (36%), Positives = 57/95 (60%)
 Frame = +1

Query: 154  PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK 333
            P+ +       +V VACG  HT+ ++ +G +YT+G ++YGQLG GD +    P +V+   
Sbjct: 957  PQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV-- 1014

Query: 334  DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 438
              + SQ++ G  HT+ LTS G +Y +G  + GQ+G
Sbjct: 1015 PGAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 35/97 (36%), Positives = 53/97 (54%)
 Frame = +1

Query: 304  LVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 483
            L P  ++    S   Q++ G  HT+ LT  G++Y +G N++GQ+G+GD      P +V  
Sbjct: 955  LAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV 1014

Query: 484  PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
            P    ++QVA G  HT+  T K  V+ +G    GQLG
Sbjct: 1015 P--GAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 33/84 (39%), Positives = 47/84 (55%)
 Frame = +1

Query: 31   VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
            V  +A G  HT  +T  G++Y +G  +YG LG GD      P +V  V G  +  VA G 
Sbjct: 968  VVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRV-QVPG-AISQVAAGS 1025

Query: 211  RHTITVSSSGSLYTYGWSKYGQLG 282
             HT+ ++S G +YT+G  + GQLG
Sbjct: 1026 NHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 36/131 (27%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
 Frame = +1

Query: 58   HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTIT 225
            H   V +DG ++  G  R G  G   +N R      P+K++ ++G  +V  AC    +  
Sbjct: 662  HALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGTSAF 721

Query: 226  VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 405
            V+ +G L  YG        H D         V  L +   ++++ G  H +AL + G+L+
Sbjct: 722  VTKTGKLIMYG----KDTAHCDAMGF-----VSELLEQHVTKVALGKAHCVALNAKGQLF 772

Query: 406  GWGWNKFGQVG 438
             +G N  GQ G
Sbjct: 773  SFGLNNKGQCG 783



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 19/55 (34%), Positives = 27/55 (49%)
 Frame = +1

Query: 463  SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPV 627
            +P  +       V QVACG  HT+  T    V+ +G    GQLG G++   + PV
Sbjct: 956  APQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPV 1010



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 12/33 (36%), Positives = 20/33 (60%)
 Frame = +1

Query: 28   SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLG 126
            ++  +AAG+ HT  +T  G +Y +G  + G LG
Sbjct: 1017 AISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 37/112 (33%), Positives = 61/112 (54%), Gaps = 7/112 (6%)
 Frame = +1

Query: 124  GLGDRNDRFVPEKVSSVEGD-------KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 282
            G GDR ++   +  +   G        + V V+CG+ H++ +  +G +YT+G+ ++GQLG
Sbjct: 876  GSGDRGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLG 935

Query: 283  HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 438
            HGD      P  V+AL   ST Q++    HT  L  DG+++ +G    GQ+G
Sbjct: 936  HGDVNSRGCPTLVQALPGPST-QVTACSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 29/81 (35%), Positives = 46/81 (56%)
 Frame = +1

Query: 40   IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 219
            ++ G  H+  + E+GD+Y +G+G++G LG GD N R  P  V ++ G    + AC   HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTACS-NHT 965

Query: 220  ITVSSSGSLYTYGWSKYGQLG 282
              +   G ++T+G    GQLG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 23/59 (38%), Positives = 35/59 (59%)
 Frame = +1

Query: 466  PAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
            P  V F  E +  QV+CG+ H++   E  +V+ +G G  GQLGHG++  R  P ++ AL
Sbjct: 893  PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQAL 951



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 4/136 (2%)
 Frame = +1

Query: 58  HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTIT 225
           H   V EDG ++  G    G  G   ++ R    + P+K+  +EG  +V  AC    +  
Sbjct: 555 HALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 226 VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 405
           +S  G LY +G           + D      V  LK    +Q++ G  HT  L  +G+++
Sbjct: 615 ISKDGELYMFGKDAI-------YSDS--SSLVSDLKGHFVTQVAMGKAHTCVLMKNGEVW 665

Query: 406 GWGWNKFGQVGAGDNA 453
            +G N  GQ G    A
Sbjct: 666 TFGVNNKGQCGRDTGA 681



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 26/82 (31%), Positives = 38/82 (46%)
 Frame = +1

Query: 349  QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRH 528
            Q+S G+ H++ L  +G +Y +G+ + GQ+G GD      P  V           AC   H
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTACS-NH 964

Query: 529  TLAFTEKKNVFAWGRGTSGQLG 594
            T        VF +G  + GQLG
Sbjct: 965  TAVLLMDGQVFTFGSFSKGQLG 986



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 45/195 (23%), Positives = 81/195 (41%), Gaps = 9/195 (4%)
 Frame = +1

Query: 37   MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL---GDRNDRFVPEKVSSVEGDKMVLVACG 207
            ++ AG E     T +G IY  G  +Y +LG+   G    ++V   ++  +  K+V  + G
Sbjct: 495  ILGAGREFALMKTANGKIYYTG--KYQSLGIKQGGPSAGKWVELPIT--KSPKIVHFSVG 550

Query: 208  W--RHTITVSSSGSLYTYGWSKYGQLGHGDFEDH----LVPHKVEALKDSSTSQISGGWR 369
                H + V+  GS++  G +  G+ G             P K+  ++       +    
Sbjct: 551  HDGSHALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNG 610

Query: 370  HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEK 549
             +  ++ DG+LY +G +        D++   S  + +F     V QVA G  HT    + 
Sbjct: 611  SSSVISKDGELYMFGKDAI----YSDSSSLVSDLKGHF-----VTQVAMGKAHTCVLMKN 661

Query: 550  KNVFAWGRGTSGQLG 594
              V+ +G    GQ G
Sbjct: 662  GEVWTFGVNNKGQCG 676



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 23/91 (25%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK---VSSVEGDKM 189
           EG  V   A     ++ +++DG++Y +G             D    +    VS ++G  +
Sbjct: 598 EGKIVVYTACNNGSSSVISKDGELYMFG------------KDAIYSDSSSLVSDLKGHFV 645

Query: 190 VLVACGWRHTITVSSSGSLYTYGWSKYGQLG 282
             VA G  HT  +  +G ++T+G +  GQ G
Sbjct: 646 TQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 43/157 (27%), Positives = 69/157 (43%), Gaps = 18/157 (11%)
 Frame = +1

Query: 196 VACGWRHTITVSSSGSLYTYGWSKYGQLG----HGDFEDHLV---PHKVEALKDSSTSQI 354
           +A G  H   +  S ++Y +G ++YGQ      +G+ ED  V   P  +  L      +I
Sbjct: 256 IASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEI 315

Query: 355 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEE-----------QKV 501
           + G  HT+ALT DG++Y WG     ++G   +    S  ++N                K+
Sbjct: 316 AAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLFAVKI 375

Query: 502 AQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVD 612
             +  G  H+ A TE   V+AWG   +   G G  +D
Sbjct: 376 KTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSID 412



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 42/169 (24%), Positives = 70/169 (41%), Gaps = 26/169 (15%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL----GDRNDRFV---PEKVSSVEGDK 186
           ++K IA+G  H  A+    ++Y WG  +YG   L    G+  D  V   P  +  +    
Sbjct: 252 NIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKG 311

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLG-----------------HGDFE--DHLV 309
           +  +A G  HT+ ++  G +Y +G     ++G                 HG F    +L 
Sbjct: 312 IKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLF 371

Query: 310 PHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 456
             K++         I  G  H+ A+T DG +Y WG+ +    G G + D
Sbjct: 372 AVKIKT--------IGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSID 412



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKV--SSVEGDKMVL 195
           + +K I  G+ H+ AVTEDG +Y WG+      GLG   +D   P ++  ++ + + ++L
Sbjct: 373 VKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILL 432

Query: 196 VACGWRHTIT 225
           +  G + +++
Sbjct: 433 IGAGGQFSVS 442



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 38/158 (24%), Positives = 57/158 (36%), Gaps = 38/158 (24%)
 Frame = +1

Query: 55  EHTAAVTEDGDIYGWGWGRYGNLGLGDR-----------NDRFVPEKVSSVEGDKMVLVA 201
           E+  A +   D++ WG G    LGLG             N     EK+    G K+V  A
Sbjct: 15  EYAKAKSTPLDVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLG---GTKIVDFA 71

Query: 202 CGWRHTITVSSSGSLYTYGWSKYGQLGH--------------------------GDF-ED 300
            G  HT+ +     ++++G +    LG                           GD  E 
Sbjct: 72  VGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEA 131

Query: 301 HLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 414
              P  VE L +    Q++     + AL S+G +Y WG
Sbjct: 132 ESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWG 169



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 8/73 (10%)
 Frame = +1

Query: 400 LYGWGWNKFGQVGAGDNADHCSPAQVNF----PEEQ----KVAQVACGWRHTLAFTEKKN 555
           ++ WG     ++G G +A +    +        EE+    K+   A G  HTLA   K  
Sbjct: 26  VFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNR 85

Query: 556 VFAWGRGTSGQLG 594
           +++WG   S  LG
Sbjct: 86  IWSWGGNDSEVLG 98



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 34/138 (24%), Positives = 52/138 (37%), Gaps = 31/138 (22%)
 Frame = +1

Query: 322 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF------------------GQVGAGD 447
           E L  +     + G  HT+AL    +++ WG N                    G+ G  D
Sbjct: 60  EKLGGTKIVDFAVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDD 119

Query: 448 NAD---------HCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG--RGTSGQLG 594
           + D           +PA V    E ++ Q+A     + A     +V++WG  R   G LG
Sbjct: 120 DDDDEDGDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLG 179

Query: 595 --HGEIVDRNTPVIIDAL 642
               EI  + TP+ I  L
Sbjct: 180 FLRDEIKLQKTPLKIKEL 197

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 59/224 (26%), Positives = 89/224 (39%), Gaps = 37/224 (16%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRH- 216
           IAAG  H   + E G +  +G G  G LG   R      + +    GD + LV   ++H 
Sbjct: 305 IAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHL-LVPLRFKHK 363

Query: 217 -----------------TITVSSSGSLYTYGWSKYGQLG--------HGDFEDH-----L 306
                            TI     G  Y +G + Y QLG          D +D+      
Sbjct: 364 GKFFDVVAKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVF 423

Query: 307 VPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG-----DNADHCSPA 471
           +P +  A     T     G +H + L SDGK++  G N    +G G     D+  H    
Sbjct: 424 LPAEAPAFGAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYD 483

Query: 472 QVNFPE-EQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHG 600
            +   E + K+  V+     ++A++E    +AWG  T+GQLG G
Sbjct: 484 TIQEIEFDSKIVGVSAKLATSIAWSEDGTAYAWGFDTTGQLGLG 527



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 61/226 (26%), Positives = 92/226 (40%), Gaps = 36/226 (15%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGR--YGNLGLGDRNDRF--VPEKVSSVEGDKMVLV 198
           + M+AAGA  TAA+T+ G +  WG  R   GN+ +     +    P  +      K+V +
Sbjct: 246 IVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKI 305

Query: 199 ACGWRHTITVSSSGSLYTYGWSKYGQLGHG-------------DFEDHLV-----PHKVE 324
           A G  H + +   G L T+G  + GQLG               +  DHL+      HK +
Sbjct: 306 AAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKGK 365

Query: 325 ALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG-DNADHCSPAQVN------- 480
                + +  + G+  T+    DGK Y +G N + Q+G   D AD     Q N       
Sbjct: 366 FFDVVAKNVFASGF-WTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFL 424

Query: 481 ------FPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHG 600
                 F  E+    +  G +H +       VFA G+ T   LG G
Sbjct: 425 PAEAPAFGAERTFVNIE-GVQHVVILGSDGKVFAMGKNTDNALGLG 469



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 19/162 (11%)
 Frame = +1

Query: 16  FEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL--------GDRNDR-----FVP 156
           F  +  K + A    T    EDG  Y +G   Y  LG+         D  D      F+P
Sbjct: 366 FFDVVAKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLP 425

Query: 157 EKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG-----DFEDHLVPHKV 321
            +  +   ++  +   G +H + + S G ++  G +    LG G     D + H +   +
Sbjct: 426 AEAPAFGAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTI 485

Query: 322 EALK-DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 444
           + ++ DS    +S     ++A + DG  Y WG++  GQ+G G
Sbjct: 486 QEIEFDSKIVGVSAKLATSIAWSEDGTAYAWGFDTTGQLGLG 527



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 53/212 (25%), Positives = 87/212 (41%), Gaps = 17/212 (8%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL--------GLGDRNDRFVPEKVSSV 174
           EG+      AG  H+A +T +G++Y  G    G +        G  D   +   E+    
Sbjct: 183 EGLKPLQAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEK 242

Query: 175 EGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ- 351
           EG K+V++A G   T  ++  GS+  +G  +     +G+ + H + HK++        Q 
Sbjct: 243 EG-KIVMLAAGASFTAALTDQGSVIAWGNLRN---SNGNVDVHPLLHKMQEAPVVIVHQA 298

Query: 352 ------ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVA 513
                 I+ G  H + L   G L  +G  + GQ+G          ++    E      V 
Sbjct: 299 KRKIVKIAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIR-SKYMCDESGDHLLVP 357

Query: 514 CGWRHTLAFTE--KKNVFAWGRGTSGQLGHGE 603
             ++H   F +   KNVFA G  T   + HGE
Sbjct: 358 LRFKHKGKFFDVVAKNVFASGFWT---IVHGE 386



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 6/76 (7%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLG--DRNDRFV--PEKVSS--VEGD 183
           G+S K+  +      A +EDG  Y WG+   G LGLG  D +++ V  PE++SS  ++G 
Sbjct: 496 GVSAKLATS-----IAWSEDGTAYAWGFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGY 550

Query: 184 KMVLVACGWRHTITVS 231
            ++  +   +HT+ ++
Sbjct: 551 SIIGASISDQHTLIIA 566

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 45/160 (28%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
 Frame = +1

Query: 154 PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG---W-SKYGQLGHGD--FEDHLVPH 315
           PE++    G  ++  A G RH + ++  G +Y++G   W S+  ++       E  LV H
Sbjct: 32  PERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEICPSSPLLESALVGH 91

Query: 316 KVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ 495
            V          ++ G  H+ A+T  G +Y WG N  GQ    +      P+ V+  + +
Sbjct: 92  HVIT--------VATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSE 143

Query: 496 -------KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
                  ++ Q+ACG  HTLA +  + ++AWG G   QLG
Sbjct: 144 TSPSLAVRILQLACGEEHTLALSLSREIWAWGTGC--QLG 181



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 53/187 (28%), Positives = 83/187 (44%), Gaps = 12/187 (6%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK---VSSVEGDKMV 192
           G +V   A G  H   +TEDG++Y      +G L     +    P      S++ G  ++
Sbjct: 40  GKTVLQAALGVRHGVLLTEDGEVYS-----FGTLPWKSESAEICPSSPLLESALVGHHVI 94

Query: 193 LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------- 348
            VA G  H+  V+ SG +Y +G +  GQ    + +    P  V ++ DS TS        
Sbjct: 95  TVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPV-SISDSETSPSLAVRIL 153

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVG-AGDNADHCSPAQVNFPEEQKVAQVACGWR 525
           Q++ G  HT+AL+   ++  W W    Q+G          P +V     + V QVACG  
Sbjct: 154 QLACGEEHTLALSLSREI--WAWGTGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAF 211

Query: 526 HTLAFTE 546
           H+LA  +
Sbjct: 212 HSLALVQ 218



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 39/120 (32%), Positives = 57/120 (47%)
 Frame = +1

Query: 244 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 423
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 522 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNT 581

Query: 424 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           FGQ+G  +      P       E  V  VA G  ++L   + ++ F  G   SG+    E
Sbjct: 582 FGQLGHSE-FPTTVPRLSKVSSENGVWSVAAGQDYSLFLVDTED-FQPGLYYSGRQDRAE 639



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 27/69 (39%), Positives = 38/69 (55%)
 Frame = +1

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           +++ WG  K GQ+G GD      P  V   + ++V  +  G  H+LA T K  V++WG  
Sbjct: 521 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSN 580

Query: 577 TSGQLGHGE 603
           T GQLGH E
Sbjct: 581 TFGQLGHSE 589



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 26/100 (26%), Positives = 55/100 (55%)
 Frame = +1

Query: 85  DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWS 264
           +++ WG G+ G LG GD   R  P  V  ++G +++ +  G  H++ +++   +Y++G +
Sbjct: 521 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSN 580

Query: 265 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            +GQLGH +F    VP   +   ++    ++ G  +++ L
Sbjct: 581 TFGQLGHSEFPT-TVPRLSKVSSENGVWSVAAGQDYSLFL 619



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 42/134 (31%), Positives = 63/134 (47%), Gaps = 10/134 (7%)
 Frame = +1

Query: 13  AFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE----KVSSVEG 180
           A  G  V  +A G+ H+ AVTE G +Y WG    G   +   N ++VPE     +S  E 
Sbjct: 87  ALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVA--NQQYVPEPSPVSISDSET 144

Query: 181 D-----KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV-PHKVEALKDSS 342
                 +++ +ACG  HT+ +S S  +  + W    QLG       +  P KVE L    
Sbjct: 145 SPSLAVRILQLACGEEHTLALSLSREI--WAWGTGCQLGLITTTFPVTKPQKVEHLAGRV 202

Query: 343 TSQISGGWRHTMAL 384
             Q++ G  H++AL
Sbjct: 203 VLQVACGAFHSLAL 216



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 13/32 (40%), Positives = 21/32 (65%)
 Frame = +1

Query: 547 KKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
           +  V+ WG+G  GQLGHG+++ R  P+ +  L
Sbjct: 519 RTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL 550

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 35/104 (33%), Positives = 51/104 (49%)
 Frame = +1

Query: 244 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 423
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 424 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 555
           FGQ+G  D      P       E  V  VA G  ++L   + ++
Sbjct: 588 FGQLGHSD-FPTTVPRLAKISSENGVWSVAAGRDYSLFLVDTED 630



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 12/187 (6%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWG---WGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 192
           G +V   A G +H   +TEDG++Y +G   W R G + +   +    P   +++ G  +V
Sbjct: 40  GKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPSS----PILENALVGQYVV 94

Query: 193 LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------- 348
            VA G  H+  V+ +G  Y +G +  GQ    + +    P+ V ++ DS  S        
Sbjct: 95  TVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPV-SIADSEASPLLAVRIL 153

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA-DHCSPAQVNFPEEQKVAQVACGWR 525
           Q++ G  HT+AL+   ++  W W    Q+G    A     P +V     + V QVACG  
Sbjct: 154 QLACGEEHTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAF 211

Query: 526 HTLAFTE 546
           H+LA  +
Sbjct: 212 HSLALVQ 218



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 8/155 (5%)
 Frame = +1

Query: 154 PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFED-HLVPHKVEAL 330
           PE++    G  ++  A G +H + ++  G +Y++G   +     G  E     P    AL
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENAL 88

Query: 331 KDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ----- 495
                  ++ G  H+ A+T +G  Y WG N  GQ    +      P  V+  + +     
Sbjct: 89  VGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148

Query: 496 --KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
             ++ Q+ACG  HTLA +  + ++AWG G   QLG
Sbjct: 149 AVRILQLACGEEHTLALSISREIWAWGTGC--QLG 181



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 27/100 (27%), Positives = 55/100 (55%)
 Frame = +1

Query: 85  DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWS 264
           +++ WG G+ G LG GD   R  P  V  ++G +++ +  G  H++ +++   +Y++G +
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 265 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            +GQLGH DF    VP   +   ++    ++ G  +++ L
Sbjct: 587 TFGQLGHSDFPT-TVPRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 26/69 (37%), Positives = 38/69 (55%)
 Frame = +1

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           +++ WG  K GQ+G GD      P  V   + ++V  +  G  H+LA T K  V++WG  
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 577 TSGQLGHGE 603
           T GQLGH +
Sbjct: 587 TFGQLGHSD 595



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 10/138 (7%)
 Frame = +1

Query: 1   IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE------- 159
           I   A  G  V  +A G+ H+ AVT++G  Y WG    G   +   N ++VPE       
Sbjct: 83  ILENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVA--NQQYVPEPNPVSIA 140

Query: 160 --KVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV-PHKVEAL 330
             + S +   +++ +ACG  HT+ +S S  +  + W    QLG       +  P KVE L
Sbjct: 141 DSEASPLLAVRILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHL 198

Query: 331 KDSSTSQISGGWRHTMAL 384
                 Q++ G  H++AL
Sbjct: 199 AGRVVLQVACGAFHSLAL 216



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 13/32 (40%), Positives = 21/32 (65%)
 Frame = +1

Query: 547 KKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
           +  V+ WG+G  GQLGHG+++ R  P+ +  L
Sbjct: 525 RTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL 556

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 34/104 (32%), Positives = 51/104 (49%)
 Frame = +1

Query: 244 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 423
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 424 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKN 555
           FGQ+G  D      P       E  V  +A G  ++L   + ++
Sbjct: 588 FGQLGHSD-FPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 8/155 (5%)
 Frame = +1

Query: 154 PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFED-HLVPHKVEAL 330
           PE++    G  ++  A G +H + ++  G +Y++G   +     G  E     P    AL
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENAL 88

Query: 331 KDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ----- 495
                  ++ G  H+ A+T +G  Y WG N  GQ    +      P  V+  + +     
Sbjct: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148

Query: 496 --KVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLG 594
             ++ Q+ACG  HTLA +  + ++AWG G   QLG
Sbjct: 149 AVRILQLACGEEHTLALSISREIWAWGTGC--QLG 181



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 12/187 (6%)
 Frame = +1

Query: 22  GISVKMIAAGAEHTAAVTEDGDIYGWG---WGRYGNLGLGDRNDRFVPEKVSSVEGDKMV 192
           G +V   A G +H   +TEDG++Y +G   W R G + +   +    P   +++ G  ++
Sbjct: 40  GKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPSS----PILENALVGQYVI 94

Query: 193 LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS-------- 348
            VA G  H+  V+ +G  Y +G +  GQ    + +    P+ V ++ DS  S        
Sbjct: 95  TVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPV-SIADSEASPLLAVRIL 153

Query: 349 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA-DHCSPAQVNFPEEQKVAQVACGWR 525
           Q++ G  HT+AL+   ++  W W    Q+G    A     P +V     + V QVACG  
Sbjct: 154 QLACGEEHTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAF 211

Query: 526 HTLAFTE 546
           H+LA  +
Sbjct: 212 HSLALVQ 218



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 28/100 (28%), Positives = 55/100 (55%)
 Frame = +1

Query: 85  DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWS 264
           +++ WG G+ G LG GD   R  P  V  ++G +++ +  G  H++ +++   +Y++G +
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 265 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            +GQLGH DF    VP   +   ++    I+ G  +++ L
Sbjct: 587 TFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 26/69 (37%), Positives = 38/69 (55%)
 Frame = +1

Query: 397 KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           +++ WG  K GQ+G GD      P  V   + ++V  +  G  H+LA T K  V++WG  
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 577 TSGQLGHGE 603
           T GQLGH +
Sbjct: 587 TFGQLGHSD 595



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 10/138 (7%)
 Frame = +1

Query: 1   IRHEAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE------- 159
           I   A  G  V  +A G+ H+ AVT++G  Y WG    G   +   N ++VPE       
Sbjct: 83  ILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVA--NQQYVPEPNPVSIA 140

Query: 160 --KVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV-PHKVEAL 330
             + S +   +++ +ACG  HT+ +S S  +  + W    QLG       +  P KVE L
Sbjct: 141 DSEASPLLAVRILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHL 198

Query: 331 KDSSTSQISGGWRHTMAL 384
                 Q++ G  H++AL
Sbjct: 199 AGRVVLQVACGAFHSLAL 216



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 13/32 (40%), Positives = 21/32 (65%)
 Frame = +1

Query: 547 KKNVFAWGRGTSGQLGHGEIVDRNTPVIIDAL 642
           +  V+ WG+G  GQLGHG+++ R  P+ +  L
Sbjct: 525 RTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL 556

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 32/86 (37%), Positives = 45/86 (52%)
 Frame = +1

Query: 334  DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVA 513
            D   S +S G  HT+ L SD +++ +G N  GQ+G GD     +P QV  P +  + QVA
Sbjct: 766  DVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVA 825

Query: 514  CGWRHTLAFTEKKNVFAWGRGTSGQL 591
             G  HT+      +VF +G    GQL
Sbjct: 826  AGSNHTILRANDGSVFTFGAFGKGQL 851



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
 Frame = +1

Query: 25   ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 204
            + V  ++ G  HT  +  D  ++ +G   +G LG+GD   +  P++V       +V VA 
Sbjct: 767  VKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAA 826

Query: 205  GWRHTITVSSSGSLYTYGWSKYGQLGHGDFED---HLVPHKVEALKDSSTSQISGGW--- 366
            G  HTI  ++ GS++T+G    GQL     E    + +P KV        +    GW   
Sbjct: 827  GSNHTILRANDGSVFTFGAFGKGQLARPAGEKAGWNAIPEKVSGFGPGFNA--FAGWIGA 884

Query: 367  --------RHTMALTSDGKL 402
                     HT  L+SD  L
Sbjct: 885  DGDSSIIHSHTALLSSDNIL 904



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 30/92 (32%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
 Frame = +1

Query: 184  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 363
            K+  V+CG  HT+ ++S   ++T+G + +GQLG GD      P +V    D+   Q++ G
Sbjct: 768  KVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAG 827

Query: 364  WRHTMALTSDGKLYGWGWNKFGQVG--AGDNA 453
              HT+   +DG ++ +G    GQ+   AG+ A
Sbjct: 828  SNHTILRANDGSVFTFGAFGKGQLARPAGEKA 859



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/47 (40%), Positives = 28/47 (59%)
 Frame = +1

Query: 484 PEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
           P + KV+ V+CG  HT+     + VF +G    GQLG G+ + +NTP
Sbjct: 764 PHDVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTP 810

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 36/134 (26%), Positives = 54/134 (40%)
 Frame = +1

Query: 19  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLV 198
           +G  V+ IA G  H+  +T DG++ G G  R G L       +    +   V    +V V
Sbjct: 34  DGAIVRKIACGGNHSVMLTNDGNLVGCGDNRRGELDSAQALRQVHDWRPVEVPAP-VVDV 92

Query: 199 ACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTM 378
           ACGW  T+ V + G ++  G   Y      +F    VP     L  +       G     
Sbjct: 93  ACGWDTTVIVDADGRVWQRGGGCY------EFTQQHVP-----LNSNDERIAVYGCFQNF 141

Query: 379 ALTSDGKLYGWGWN 420
            +    ++YGWG N
Sbjct: 142 VVVQGTRVYGWGSN 155



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 36/115 (31%), Positives = 52/115 (45%), Gaps = 4/115 (3%)
 Frame = +1

Query: 244 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TSQISGGWRHTMALTSDGKLYGWGWN 420
           +Y +G +   QLG G  ED   P +     D +   +I+ G  H++ LT+DG L G G N
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 421 KFGQVGAGD---NADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           + G++ +           P +V  P    V  VACGW  T+       V  W RG
Sbjct: 64  RRGELDSAQALRQVHDWRPVEVPAP----VVDVACGWDTTVIVDADGRV--WQRG 112



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
 Frame = +1

Query: 400 LYGWGWNKFGQVGAGDNADHCSPAQ-VNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRG 576
           +Y +G N   Q+G G + D  +P + V   +   V ++ACG  H++  T   N+   G  
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 577 TSGQL 591
             G+L
Sbjct: 64  RRGEL 68



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 13/36 (36%), Positives = 19/36 (52%), Gaps = 7/36 (19%)
 Frame = +1

Query: 40  IAAGAEHTAAVTEDGD-------IYGWGWGRYGNLG 126
           +A G+EH    T + +       +Y WGWG +GN G
Sbjct: 266 VATGSEHGILTTANQEGKSHCYNVYCWGWGEHGNCG 301

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>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
 Frame = +1

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G+ H   +   G+++  G N++GQ+G GD  D   P QV++   Q+   + CG  H+L  
Sbjct: 375 GYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHY--LQRPIALWCGLNHSLVL 432

Query: 541 TE----KKNVFAWGRGTSGQL 591
           ++     K +   G G  G+L
Sbjct: 433 SQTSDFSKELLGCGCGAGGRL 453



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/69 (34%), Positives = 36/69 (52%)
 Frame = +1

Query: 31  VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW 210
           V   A G  H   V E G I+  G  RYG LG GD+ DR  P +V  ++  + + + CG 
Sbjct: 369 VLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQ--RPIALWCGL 426

Query: 211 RHTITVSSS 237
            H++ +S +
Sbjct: 427 NHSLVLSQT 435



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 25/73 (34%), Positives = 33/73 (45%)
 Frame = +1

Query: 424 FGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGE 603
           FG + A D  DH  P  ++ P   KV   A G+ H     E   +F  G    GQLG G+
Sbjct: 346 FGTLQAFDPLDHQMPLALSLPA--KVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGD 403

Query: 604 IVDRNTPVIIDAL 642
            +DR  P  +  L
Sbjct: 404 KMDRGEPTQVHYL 416



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 15/115 (13%)
 Frame = +1

Query: 112 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGD 291
           +G L   D  D  +P  +S     K++  A G+ H   V   G ++  G ++YGQLG GD
Sbjct: 346 FGTLQAFDPLDHQMPLALSLPA--KVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGD 403

Query: 292 FEDHLVPHKVEALKDSSTSQISGGWRHTMAL--TSD-------------GKLYGW 411
             D   P +V  L+      +  G  H++ L  TSD             G+L GW
Sbjct: 404 KMDRGEPTQVHYLQ--RPIALWCGLNHSLVLSQTSDFSKELLGCGCGAGGRLPGW 456

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>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 24/65 (36%), Positives = 35/65 (53%)
 Frame = +1

Query: 43  AAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTI 222
           A G  H   V E G I+  G  RYG LG GD+ DR  P +V  ++  + + + CG  H++
Sbjct: 363 ALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQ--RPITLWCGLNHSL 420

Query: 223 TVSSS 237
            +S S
Sbjct: 421 VLSQS 425



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
 Frame = +1

Query: 361 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAF 540
           G+ H   +   G+++  G N++GQ+G GD  D   P QV +   Q+   + CG  H+L  
Sbjct: 365 GYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCY--LQRPITLWCGLNHSLVL 422

Query: 541 TE----KKNVFAWGRGTSGQL 591
           ++     K +   G G  G+L
Sbjct: 423 SQSSEFSKELLGCGCGAGGRL 443



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 47/175 (26%), Positives = 72/175 (41%), Gaps = 11/175 (6%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIY------GWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 186
           + V  + +    T  VT+ G +Y      G     +G L   D  D+ +P  +S     K
Sbjct: 301 LRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPA--K 358

Query: 187 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 366
           ++  A G+ H   V   G ++  G ++YGQLG GD  D   P +V  L+   T  +  G 
Sbjct: 359 ILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQRPIT--LWCGL 416

Query: 367 RHTMALTSDG----KLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQ-KVAQVAC 516
            H++ L+       +L G G       GAG           +F + Q KV   AC
Sbjct: 417 NHSLVLSQSSEFSKELLGCG------CGAGGRLPGWPKGSASFVKLQVKVPLCAC 465



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 33/114 (28%), Positives = 47/114 (41%), Gaps = 6/114 (5%)
 Frame = +1

Query: 301 HLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY------GWGWNKFGQVGAGDNADHC 462
           H +PH   A   S+ S        T+ +T  G +Y      G   + FG + A D  D  
Sbjct: 296 HYLPHLRVACMTSNQSS-------TLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQ 348

Query: 463 SPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
            P  ++ P   K+   A G+ H     E   +F  G    GQLG G+ +DR  P
Sbjct: 349 MPLALSLPA--KILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEP 400

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>HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (Protein|
           hyperplastic discs)
          Length = 2885

 Score = 33.1 bits (74), Expect = 0.73
 Identities = 28/117 (23%), Positives = 45/117 (38%)
 Frame = +1

Query: 220 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 399
           I +S SG LY + WS   +    + E+   P  V          IS  +     +T   +
Sbjct: 374 IALSESGDLYQWRWSD-AEPYKSETENVYHPKTVSLNIVERVELISANFIRCSVVTETNR 432

Query: 400 LYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHTLAFTEKKNVFAWG 570
           +  W   + G +GA    +H   A   F  +       C   +T+  TE  N++ WG
Sbjct: 433 VATWMDEQLGYIGA--KLEHSCCAFNEFISDSITKIYVCSL-YTVVKTESNNIYWWG 486



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 31/136 (22%), Positives = 57/136 (41%)
 Frame = +1

Query: 25  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 204
           +  K I A      A++E GD+Y W W         +  + + P+ VS    +++ L++ 
Sbjct: 361 VRFKTIGALYSEFIALSESGDLYQWRWSD-AEPYKSETENVYHPKTVSLNIVERVELISA 419

Query: 205 GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 384
            +     V+ +  + T+   + G +G     +H      E + DS T +I     +T+  
Sbjct: 420 NFIRCSVVTETNRVATWMDEQLGYIGAK--LEHSCCAFNEFISDSIT-KIYVCSLYTVVK 476

Query: 385 TSDGKLYGWGWNKFGQ 432
           T    +Y WG   F Q
Sbjct: 477 TESNNIYWWGVLPFDQ 492

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>S12A2_HUMAN (P55011) Solute carrier family 12 member 2 (Bumetanide-sensitive|
           sodium-(potassium)-chloride cotransporter 1)
           (Basolateral Na-K-Cl symporter)
          Length = 1212

 Score = 33.1 bits (74), Expect = 0.73
 Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 4/86 (4%)
 Frame = -2

Query: 612 VNYFPMTELSTSTPSPCKHIFLFCESKSVPPSTSNLGNFLFLRKIN----LGWGTVISII 445
           VN   +TEL+  T + CK  F F   +S P S   + NF  +  ++    L    + S  
Sbjct: 552 VNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSAT 611

Query: 444 ASSNLPKLVPSPSIKFSI*CKCHCVP 367
            SS L  LV +P I F   CK +  P
Sbjct: 612 LSSALASLVSAPKI-FQALCKDNIYP 636

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 33.1 bits (74), Expect = 0.73
 Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
 Frame = +1

Query: 28  SVKMIAAGAEHTAAVTEDGDIYGWGWGRY--GNLGLGDRNDRFVPE-KVSSVEGDKMVLV 198
           +V  +A+G  HT A+TE G +Y WG      G LGLG  +++ V E  + + EG + + V
Sbjct: 547 NVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGP-SEKIVNELHIGNWEGQRNIRV 605



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 19/81 (23%), Positives = 35/81 (43%)
 Frame = +1

Query: 352 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPEEQKVAQVACGWRHT 531
           +S G  H +A+ +D  +Y W   +  Q    + A+   P++   P    + ++A GW   
Sbjct: 369 VSSGRSHFLAMDTDNNIYSWDSTESDQGVKIEFAN--LPSRATNP----ILKIASGWNFN 422

Query: 532 LAFTEKKNVFAWGRGTSGQLG 594
             +  K  + AW    + Q G
Sbjct: 423 CCYIYKVGLVAWKERDAIQKG 443



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 19/87 (21%)
 Frame = +1

Query: 352 ISGGWRHTMALTSDGKLYGWGWNK--FGQVGAGD-----------------NADHCSPAQ 474
           ++ G  HT+ALT  G LY WG      G +G G                  N     P +
Sbjct: 551 VASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEGQRNIRVVKPTK 610

Query: 475 VNFPEEQKVAQVACGWRHTLAFTEKKN 555
           +  PE+     V  G   T A   KK+
Sbjct: 611 IELPEDYICVSVTAGGWQTGALIIKKH 637

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>PWP2_SCHPO (Q9C1X1) Periodic tryptophan protein 2 homolog|
          Length = 854

 Score = 32.3 bits (72), Expect = 1.3
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +1

Query: 217 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDS-STSQISGGWRHTMALTSD 393
           T+TV+S+G     G SK GQL   +++      K ++  D+ ST Q S   +  +    D
Sbjct: 301 TLTVNSTGDWIAIGSSKLGQLLVWEWQSESYVLKQQSHYDALSTLQYSSDGQRIITGADD 360

Query: 394 GKLYGWGWN 420
           GK+  W  N
Sbjct: 361 GKIKVWDMN 369

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>HCN1_HUMAN (O60741) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (Brain cyclic nucleotide
           gated channel 1) (BCNG-1)
          Length = 890

 Score = 31.2 bits (69), Expect = 2.8
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 182 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 48
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 664 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 707

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>ERG6_NEUCR (Q9P3R1) Sterol 24-C-methyltransferase (EC 2.1.1.41)|
           (Delta(24)-sterol C-methyltransferase)
          Length = 379

 Score = 31.2 bits (69), Expect = 2.8
 Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 8/84 (9%)
 Frame = +1

Query: 292 FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWN-KFGQVGAGDNA----- 453
           F++     + +A +++ T + +   RH   L +D   YGWG    F +   G++      
Sbjct: 55  FDNKTAEAETQADREARTKEYATLTRHYYNLATDIYEYGWGQCFHFCRYSPGESFYQAIA 114

Query: 454 --DHCSPAQVNFPEEQKVAQVACG 519
             +H   AQ+   ++ KV  V CG
Sbjct: 115 RHEHYLAAQIGIKKDMKVLDVGCG 138

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>HCN1_RAT (Q9JKB0) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1
          Length = 910

 Score = 31.2 bits (69), Expect = 2.8
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 182 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 48
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 653 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 696

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>HCN1_MOUSE (O88704) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (Brain cyclic nucleotide
           gated channel 1) (BCNG-1) (Hyperpolarization-activated
           cation channel 2) (HAC-2)
          Length = 910

 Score = 31.2 bits (69), Expect = 2.8
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 182 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 48
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 653 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 696

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>HCN1_RABIT (Q9MZS1) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (rbHCN1)
          Length = 822

 Score = 31.2 bits (69), Expect = 2.8
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -3

Query: 182 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 48
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 600 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 643

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>VGLD_PRVRI (P07645) Protein gp50|
          Length = 402

 Score = 30.8 bits (68), Expect = 3.6
 Identities = 15/43 (34%), Positives = 22/43 (51%)
 Frame = -3

Query: 206 PHATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPS 78
           P     +  P+T D  +G   + R PRP+ P+RP   P + PS
Sbjct: 288 PAPPDRLPEPATRDHAAGGRPTPRPPRPETPHRPFAPPAVVPS 330

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>FREM2_LYTVA (Q9GV77) Extracellular matrix protein 3 precursor (FREM2 homolog)|
          Length = 3103

 Score = 30.8 bits (68), Expect = 3.6
 Identities = 15/48 (31%), Positives = 24/48 (50%)
 Frame = +2

Query: 332  RIALHPRFQVDGGTQWHLHQMENFMDGDGTSLGKLELAIMLITVPQPR 475
            R+A    F+VD G  W+LH + +    + + +GK E     I+  Q R
Sbjct: 2955 RLASDALFEVDYGRTWYLHSIYSMRSSESSGIGKRETEHHAISSRQRR 3002

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>KLPA_EMENI (P28739) Kinesin-like protein klpA|
          Length = 770

 Score = 30.4 bits (67), Expect = 4.8
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
 Frame = +1

Query: 268 YGQLGHGDFE-----DHLVPHKVEALKDSSTSQISGGWRHTM 378
           YGQ G G        D ++P  V  + +++TS    GWR+TM
Sbjct: 513 YGQTGSGKTHTMSSLDGMIPRAVHQIYETATSLEEKGWRYTM 554

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>STC2_STAAU (P17855) Staphylocoagulase precursor|
          Length = 715

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 25/97 (25%), Positives = 38/97 (39%), Gaps = 2/97 (2%)
 Frame = +1

Query: 340 STSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF--PEEQKVAQVA 513
           +  Q+S G R T    S+   Y    +  GQV  G    +  P++ N          QV+
Sbjct: 541 ANGQVSYGARPTQKKPSETNAYNVTTHANGQVSYGARPTYNKPSETNAYNVTTHGNGQVS 600

Query: 514 CGWRHTLAFTEKKNVFAWGRGTSGQLGHGEIVDRNTP 624
            G R T     K N +      +GQ+ +G    +N P
Sbjct: 601 YGARPTYKKPSKTNAYNVTTHANGQVSYGARPTQNKP 637

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>MUC_CHICK (P01875) Ig mu chain C region|
          Length = 446

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
 Frame = -3

Query: 425 NLFHPHP*SFPSDVSAIVCLHPPEIWDVELSFK-ASTLCGTR 303
           ++ +P P   P+ +   V +HPP   D E  F+ AS LC TR
Sbjct: 97  SVMNPGPIPTPNGIPLFVTMHPPSREDFEGPFRNASILCQTR 138

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>LOXC_ARATH (P38418) Lipoxygenase, chloroplast precursor (EC 1.13.11.12)|
          Length = 896

 Score = 29.6 bits (65), Expect = 8.1
 Identities = 14/45 (31%), Positives = 24/45 (53%)
 Frame = +1

Query: 322 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 456
           +A+K+  T  +   +     +TSD +L GW W++   +G GD  D
Sbjct: 675 DAIKEWVTDYVKHYYPDEELITSDEELQGW-WSEVRNIGHGDKKD 718


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.316    0.135    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,480,076
Number of Sequences: 219361
Number of extensions: 2517665
Number of successful extensions: 8439
Number of sequences better than 10.0: 63
Number of HSP's better than 10.0 without gapping: 7139
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8021
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6143359464
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result