Clone Information

BLAST Search Result

Clone Name	bags11a24
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	117	2e-26
2	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	117	2e-26
3	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	117	2e-26
4	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	113	4e-25
5	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	111	1e-24
6	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	103	3e-22
7	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	103	4e-22
8	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	102	6e-22
9	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	102	6e-22
10	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	101	2e-21
11	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	98	1e-20
12	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	97	4e-20
13	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	95	2e-19
14	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	93	6e-19
15	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	93	6e-19
16	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	91	3e-18
17	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	89	7e-18
18	RCC2_MOUSE (Q8BK67) Protein RCC2	89	1e-17
19	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	87	3e-17
20	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	87	3e-17
21	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	86	6e-17
22	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	85	2e-16
23	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	84	2e-16
24	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	84	2e-16
25	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	84	4e-16
26	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	82	8e-16
27	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	82	1e-15
28	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	82	1e-15
29	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	79	1e-14
30	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	78	2e-14
31	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	77	4e-14
32	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	77	4e-14
33	RCC1_CANAL (P52499) Protein RCC1	76	6e-14
34	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	76	6e-14
35	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	75	1e-13
36	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	75	1e-13
37	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	75	2e-13
38	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	69	1e-11
39	RCC1_XENLA (P25183) Regulator of chromosome condensation	68	2e-11
40	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	67	5e-11
41	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	66	6e-11
42	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	61	2e-09
43	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	60	3e-09
44	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	58	2e-08
45	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	55	1e-07
46	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	47	3e-05
47	FBX24_HUMAN (O75426) F-box only protein 24	39	0.008
48	POF9_SCHPO (O74381) F-box protein pof9	35	0.015
49	FBX24_MOUSE (Q9D417) F-box only protein 24	38	0.024
50	CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 pr...	36	0.090
51	YB9W_YEAST (P38352) F-box protein YBR280C	35	0.12
52	UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homo...	33	0.58
53	TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)	32	0.99
54	NAH_SCHPO (P36606) Na(+)/H(+) antiporter	32	1.3
55	TIP_RAT (Q8R4E1) T-cell immunomodulatory protein precursor (Prot...	31	2.9
56	WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7...	31	2.9
57	DLGP4_HUMAN (Q9Y2H0) Disks large-associated protein 4 (DAP-4) (S...	30	6.4
58	DLGP4_RAT (P97839) Disks large-associated protein 4 (DAP-4) (SAP...	30	6.4
59	PHLD_MOUSE (O70362) Phosphatidylinositol-glycan-specific phospho...	30	6.4
60	YFAS_ECO57 (Q8XE35) Hypothetical UPF0192 protein yfaS precursor	29	8.4
61	PHL2_HUMAN (Q15127) Phosphatidylinositol-glycan-specific phospho...	29	8.4
62	PHL1_HUMAN (P80108) Phosphatidylinositol-glycan-specific phospho...	29	8.4
63	CUBN_CANFA (Q9TU53) Cubilin precursor	29	8.4
64	STCK_EMENI (Q00706) Putative sterigmatocystin biosynthesis fatty...	29	8.4

>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  117 bits (294), Expect = 2e-26
 Identities = 63/184 (34%), Positives = 101/184 (54%), Gaps = 8/184 (4%)
 Frame = +3

Query: 48   LKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV-- 209
            ++V  VAAGG HS  +T  G ++TWG+         D ++   P  V+ L+   +I +  
Sbjct: 4093 IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIAC 4152

Query: 210  --GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSA 383
              G    L L+ D  +W+WG+ +YG+LG G +     P++++ L+ L +V +  G   S 
Sbjct: 4153 GSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSV 4212

Query: 384  ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
            ALTK G VY WG+G++ RLG G D      P QVQ L G+ ++ ++ G  H V  T DG 
Sbjct: 4213 ALTKSGAVYTWGKGDYHRLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGE 4271

Query: 564  IFSY 575
            ++++
Sbjct: 4272 VYTW 4275



 Score =  115 bits (287), Expect = 1e-25
 Identities = 61/182 (33%), Positives = 105/182 (57%), Gaps = 8/182 (4%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV---- 209
            V  +A G T+S  +T EG ++TWG+        G  ++ + P+ V GL+ + +I V    
Sbjct: 554  VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGS 613

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
            G    LA++ +  +W+WG+ +YG+LG G +     P  +E L +L ++ +  G   S AL
Sbjct: 614  GDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIAL 673

Query: 390  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 569
            TK+G+VY+WG+G++ RLG G ++     P  ++ L G+ ++ V+ G TH +VLT D  + 
Sbjct: 674  TKDGQVYSWGKGDNQRLGHGTEEHVR-YPKLLEGLQGKKVIDVAAGSTHCLVLTEDSEVH 732

Query: 570  SY 575
            S+
Sbjct: 733  SW 734



 Score =  106 bits (265), Expect = 4e-23
 Identities = 61/196 (31%), Positives = 104/196 (53%), Gaps = 10/196 (5%)
 Frame = +3

Query: 18   IPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQGL 185
            +P P      L+  Q+  G      +T +G ++  G         G  +++STP  ++ +
Sbjct: 3977 VPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESI 4036

Query: 186  EQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            + V +  V    G  H LALS +  +++WG  E G+LG G+  P  +P  +E L  + +V
Sbjct: 4037 QHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVV 4096

Query: 354  DIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG- 530
            D+AAGG HSA +T  G++Y WG+G +GRLG  D +   + P  V+ L G  ++ ++CG  
Sbjct: 4097 DVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVEALQGHRVIDIACGSG 4155

Query: 531  -THSVVLTSDGRIFSY 575
               ++ LT D  ++S+
Sbjct: 4156 DAQTLCLTDDDTVWSW 4171



 Score =  102 bits (254), Expect = 8e-22
 Identities = 63/176 (35%), Positives = 93/176 (52%), Gaps = 8/176 (4%)
 Frame = +3

Query: 51   KVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGL--EQVSMIA 206
            +V QVA G     ++ LT EG V++WG         G  +  + P  ++ L  + V  I 
Sbjct: 3153 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIE 3212

Query: 207  VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAA 386
             GA  +LAL+   ++W WG  +Y +LG G      +P  VEGL    +V +A G  H  A
Sbjct: 3213 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA 3272

Query: 387  LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
            +T  G+VYAWG  +HG+ G G   + +  P  VQ L G+ I +V+CG +HSV  T+
Sbjct: 3273 VTDSGQVYAWGDNDHGQQGNG-TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3327



 Score =  101 bits (251), Expect = 2e-21
 Identities = 56/179 (31%), Positives = 95/179 (53%), Gaps = 12/179 (6%)
 Frame = +3

Query: 75   GTHSVVLTQEGHVWTWG----------QPWPPGDIKNISTPVRVQGLEQVSMIAVGAFHN 224
            G H + L   G V++WG             P  + K IS     Q  + V  IA G+ ++
Sbjct: 505  GHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYS 564

Query: 225  LALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKE 398
             A++ +  L+ WG   YG+LG G ++  + P+ V GL  L ++D+A G     + A+T+ 
Sbjct: 565  AAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTEN 624

Query: 399  GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            G+V++WG G++G+LG G        P  ++ L   D+++V CG   S+ LT DG+++S+
Sbjct: 625  GQVWSWGDGDYGKLGRGGSDGC-KTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSW 682



 Score =  100 bits (250), Expect = 2e-21
 Identities = 63/199 (31%), Positives = 108/199 (54%), Gaps = 13/199 (6%)
 Frame = +3

Query: 18   IPIPQRCAL--KLKVRQVA--AGGTHSVVLTQEGHVWTWGQPWPPGDI-----KNISTPV 170
            +PIP++        V++VA  +GG H+  LT +G V++WG+    G +      N   P 
Sbjct: 3034 VPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEG-DDGKLGHFSRMNCDKPR 3092

Query: 171  RVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 344
             +Q L+  ++  IA G+ H+  L+    L+ WG  EYG+LG GD   + +P  V+ L   
Sbjct: 3093 LIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH 3152

Query: 345  SLVDIAAGG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV 518
             ++ +A G     + ALT EG V++WG G+ G+LG G  +  + +P  ++ L G+ + Q+
Sbjct: 3153 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQI 3211

Query: 519  SCGGTHSVVLTSDGRIFSY 575
             CG   S+ LT  G ++++
Sbjct: 3212 ECGAQFSLALTKSGVVWTW 3230



 Score =  100 bits (249), Expect = 3e-21
 Identities = 67/203 (33%), Positives = 103/203 (50%), Gaps = 13/203 (6%)
 Frame = +3

Query: 6    RGRDIPIPQ--RCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPG-----DIKNIST 164
            +G  I +P        L V QVA G      +T EG V++ G+              +  
Sbjct: 2977 KGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPI 3036

Query: 165  PVRVQGLEQ--VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 332
            P ++  L    V  +AV  G  H  AL+VD  +++WG  + G+LG        +P  ++ 
Sbjct: 3037 PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQA 3096

Query: 333  LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 512
            L    + DIA G  HSA LT  GE+Y WG GE+GRLG GD+ ++ + P  V++L G  ++
Sbjct: 3097 LKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVI 3155

Query: 513  QVSCGG--THSVVLTSDGRIFSY 575
            QV+CG     ++ LT +G +FS+
Sbjct: 3156 QVACGSRDAQTLALTDEGLVFSW 3178



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 47/164 (28%), Positives = 82/164 (50%), Gaps = 6/164 (3%)
 Frame = +3

Query: 69   AGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAV--GAFHNLA 230
            +G   ++ LT +  VW+WG         G       P+++  L  + ++ V  G+  ++A
Sbjct: 4154 SGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVA 4213

Query: 231  LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVY 410
            L+    ++ WG  +Y +LG G      +P +V+GL    ++ IA G  H    T++GEVY
Sbjct: 4214 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4273

Query: 411  AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 542
             WG  + G+LG G   +    P  V  L G+ + +V+CG  H++
Sbjct: 4274 TWGDNDEGQLGDGTTNAIQR-PRLVAALQGKKVNRVACGSAHTL 4316



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 51/177 (28%), Positives = 86/177 (48%), Gaps = 8/177 (4%)
 Frame = +3

Query: 48   LKVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAV 209
            LKV  VA G     ++ +T+ G VW+WG         G      TP  ++ L+ + +I V
Sbjct: 604  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKV 663

Query: 210  --GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSA 383
              G+  ++AL+ D  +++WG  +  +LG G  +    P  +EGL    ++D+AAG  H  
Sbjct: 664  RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCL 723

Query: 384  ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
             LT++ EV++WG  +  +  F     +   P     L  + IV ++CG   S   +S
Sbjct: 724  VLTEDSEVHSWGSNDQCQ-HFDTLGVTKPEPTAFPGLDSKHIVGIACGPAQSFAWSS 779



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 10/151 (6%)
 Frame = +3

Query: 153 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 332
           N+  P++ +GL  + ++ V       L + R         Y Q    D      P  V+G
Sbjct: 439 NVIGPIQCEGLASLGVMQVACAEKRFLILSR-----NGRVYTQAYNSDMLA---PQLVQG 490

Query: 333 LSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL---- 494
           L++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+   +    
Sbjct: 491 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEPKVISAF 545

Query: 495 ----AGEDIVQVSCGGTHSVVLTSDGRIFSY 575
               AG+ +V ++CG T+S  +T++G ++++
Sbjct: 546 SGKQAGKHVVHIACGSTYSAAITAEGELYTW 576



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 43/132 (32%), Positives = 65/132 (49%), Gaps = 6/132 (4%)
 Frame = +3

Query: 9    GRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRV 176
            G  +P+       L V +V  G   SV LT+ G V+TWG+        G   ++  P +V
Sbjct: 4186 GCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQV 4245

Query: 177  QGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL 350
            QGL+  +V  IA G+ H +  + D  ++ WG+N+ GQLG G T    +P  V  L    +
Sbjct: 4246 QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKV 4305

Query: 351  VDIAAGGWHSAA 386
              +A G  H+ A
Sbjct: 4306 NRVACGSAHTLA 4317



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 54/163 (33%)
 Frame = +3

Query: 249  LWAWGNNEYGQ------------------------------------------------- 281
            ++ WG+N  GQ                                                 
Sbjct: 3956 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4015

Query: 282  ---LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGF 446
               LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG 
Sbjct: 4016 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4075

Query: 447  GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            G ++S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4076 G-NRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4117

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score =  117 bits (294), Expect = 2e-26
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 8/183 (4%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPG-----DIKNISTPVRVQGLEQVSM--IAV 209
           K+ Q+  G  HS+ L++ G ++ WGQ             + +TP  V+ L  V +  I+ 
Sbjct: 139 KIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISA 198

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G  H++ALS+   +++WG NE GQLG+G T+ +  P  +EGL N  +  +A GG HSA L
Sbjct: 199 GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL 258

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD-GRI 566
           T++G ++ +G G+HG+LG  +   + + P  V  L G  + Q++CG  H++   SD G++
Sbjct: 259 TQDGLLFTFGAGKHGQLGH-NSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKV 317

Query: 567 FSY 575
           FS+
Sbjct: 318 FSF 320



 Score =  105 bits (262), Expect = 9e-23
 Identities = 64/181 (35%), Positives = 100/181 (55%), Gaps = 5/181 (2%)
 Frame = +3

Query: 48  LKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTP-VRVQGLEQ---VSMIAVGA 215
           +K+  V  G  H ++L+ +G          P +  N S   +R + + Q   +  I  G 
Sbjct: 97  MKIHSVDQGAEHMLILSSDGK---------PFEYDNYSMKHLRFESILQEKKIIQITCGD 147

Query: 216 FHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
           +H+LALS    L+AWG N +GQLG+G   P  + P  VE L+ + L  I+AG  HS AL+
Sbjct: 148 YHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALS 207

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
             G +Y+WG+ E G+LG G  +S    P  ++ L  + +  V+CGG+HS +LT DG +F+
Sbjct: 208 MSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFT 266

Query: 573 Y 575
           +
Sbjct: 267 F 267

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  117 bits (293), Expect = 2e-26
 Identities = 62/184 (33%), Positives = 101/184 (54%), Gaps = 8/184 (4%)
 Frame = +3

Query: 48   LKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV-- 209
            ++V  VAAGG HS  +T  G ++TWG+         D ++   P  V+ L+   ++ +  
Sbjct: 4091 IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIAC 4150

Query: 210  --GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSA 383
              G    L L+ D  +W+WG+ +YG+LG G +     P++++ L+ L +V +  G   S 
Sbjct: 4151 GSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSV 4210

Query: 384  ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
            ALTK G VY WG+G++ RLG G D      P QVQ L G+ ++ ++ G  H V  T DG 
Sbjct: 4211 ALTKSGAVYTWGKGDYHRLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGE 4269

Query: 564  IFSY 575
            ++++
Sbjct: 4270 VYTW 4273



 Score =  114 bits (284), Expect = 3e-25
 Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 8/182 (4%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV---- 209
            V  +A G T+S  +T EG ++TWG+        G  ++ + P+ V GL+ + +I V    
Sbjct: 553  VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGS 612

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
            G    LA++ +  +W+WG+ +YG+LG G +     P  +E L +L +V +  G   S AL
Sbjct: 613  GDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIAL 672

Query: 390  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 569
            TK+G+VY+WG+G++ RLG G ++     P  ++ L G+ ++ V+ G TH + LT D  + 
Sbjct: 673  TKDGQVYSWGKGDNQRLGHGTEEHVR-YPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVH 731

Query: 570  SY 575
            S+
Sbjct: 732  SW 733



 Score =  107 bits (266), Expect = 3e-23
 Identities = 62/196 (31%), Positives = 104/196 (53%), Gaps = 10/196 (5%)
 Frame = +3

Query: 18   IPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQGL 185
            +P P      L+  Q+  G      +T +G ++  G         G  +++STP  ++ +
Sbjct: 3975 VPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESI 4034

Query: 186  EQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            + V +  V    G  H LALS +  +++WG  E G+LG G+  P  +P  +E L  + +V
Sbjct: 4035 QHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVV 4094

Query: 354  DIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG- 530
            D+AAGG HSA +T  G++Y WG+G +GRLG  D +   + P  V+ L G  +V ++CG  
Sbjct: 4095 DVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVEALQGHRVVDIACGSG 4153

Query: 531  -THSVVLTSDGRIFSY 575
               ++ LT D  ++S+
Sbjct: 4154 DAQTLCLTDDDTVWSW 4169



 Score =  104 bits (260), Expect = 2e-22
 Identities = 71/203 (34%), Positives = 105/203 (51%), Gaps = 13/203 (6%)
 Frame = +3

Query: 6    RGRDIPIPQ--RCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIST----- 164
            +G  I +P        L V QVA G      +T EG V+  G+         IS+     
Sbjct: 2976 KGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPI 3035

Query: 165  PVRVQGLEQ--VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 332
            P ++  L    V  +AV  G  H  AL+VD  +++WG  + G+LG        +P  +E 
Sbjct: 3036 PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA 3095

Query: 333  LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 512
            L    + DIA G  HSAALT  GE+Y WG GE+GRLG GD+ ++ + P  V++L G  ++
Sbjct: 3096 LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVI 3154

Query: 513  QVSCGG--THSVVLTSDGRIFSY 575
            QV+CG     ++ LT +G +FS+
Sbjct: 3155 QVACGSRDAQTLALTDEGLVFSW 3177



 Score =  102 bits (254), Expect = 8e-22
 Identities = 63/176 (35%), Positives = 93/176 (52%), Gaps = 8/176 (4%)
 Frame = +3

Query: 51   KVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGL--EQVSMIA 206
            +V QVA G     ++ LT EG V++WG         G  +  + P  ++ L  + V  I 
Sbjct: 3152 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIE 3211

Query: 207  VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAA 386
             GA  +LAL+   ++W WG  +Y +LG G      +P  VEGL    +V +A G  H  A
Sbjct: 3212 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA 3271

Query: 387  LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
            +T  G+VYAWG  +HG+ G G   + +  P  VQ L G+ I +V+CG +HSV  T+
Sbjct: 3272 VTDSGQVYAWGDNDHGQQGNG-TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326



 Score =  101 bits (252), Expect = 1e-21
 Identities = 63/199 (31%), Positives = 109/199 (54%), Gaps = 13/199 (6%)
 Frame = +3

Query: 18   IPIPQRCAL--KLKVRQVA--AGGTHSVVLTQEGHVWTWGQPWPPGDI-----KNISTPV 170
            +PIP++        V++VA  +GG H+  LT +G V++WG+    G +      N   P 
Sbjct: 3033 VPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEG-DDGKLGHFSRMNCDKPR 3091

Query: 171  RVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 344
             ++ L+  ++  IA G+ H+ AL+    L+ WG  EYG+LG GD   + +P  V+ L   
Sbjct: 3092 LIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGH 3151

Query: 345  SLVDIAAGG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV 518
             ++ +A G     + ALT EG V++WG G+ G+LG G  +  + +P  ++ L G+ + Q+
Sbjct: 3152 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQI 3210

Query: 519  SCGGTHSVVLTSDGRIFSY 575
             CG   S+ LT  G ++++
Sbjct: 3211 ECGAQFSLALTKSGVVWTW 3229



 Score =  101 bits (252), Expect = 1e-21
 Identities = 57/179 (31%), Positives = 95/179 (53%), Gaps = 12/179 (6%)
 Frame = +3

Query: 75   GTHSVVLTQEGHVWTWG----------QPWPPGDIKNISTPVRVQGLEQVSMIAVGAFHN 224
            G H + L   G V++WG             P  + K IS     Q  + V  IA G+ ++
Sbjct: 504  GHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYS 563

Query: 225  LALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKE 398
             A++ +  L+ WG   YG+LG G ++  + P+ V GL  L ++D+A G     + A+T+ 
Sbjct: 564  AAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTEN 623

Query: 399  GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            G+V++WG G++G+LG G        P  ++ L   D+V+V CG   S+ LT DG+++S+
Sbjct: 624  GQVWSWGDGDYGKLGRGGSDGC-KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSW 681



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 47/164 (28%), Positives = 82/164 (50%), Gaps = 6/164 (3%)
 Frame = +3

Query: 69   AGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAV--GAFHNLA 230
            +G   ++ LT +  VW+WG         G       P+++  L  + ++ V  G+  ++A
Sbjct: 4152 SGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVA 4211

Query: 231  LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVY 410
            L+    ++ WG  +Y +LG G      +P +V+GL    ++ IA G  H    T++GEVY
Sbjct: 4212 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4271

Query: 411  AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 542
             WG  + G+LG G   +    P  V  L G+ + +V+CG  H++
Sbjct: 4272 TWGDNDEGQLGDGTTNAIQR-PRLVAALQGKKVNRVACGSAHTL 4314



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 51/177 (28%), Positives = 89/177 (50%), Gaps = 8/177 (4%)
 Frame = +3

Query: 48   LKVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAV 209
            LKV  VA G     ++ +T+ G VW+WG         G      TP  ++ L+ + ++ V
Sbjct: 603  LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKV 662

Query: 210  --GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSA 383
              G+  ++AL+ D  +++WG  +  +LG G  +    P  +EGL    ++D+AAG  H  
Sbjct: 663  RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCL 722

Query: 384  ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
            ALT++ EV++WG  +  +  F   + +   P  +  L  + IV ++CG   S   +S
Sbjct: 723  ALTEDSEVHSWGSNDQCQ-HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 10/151 (6%)
 Frame = +3

Query: 153 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 332
           N+  P++ +GL  + +  +       L + R         Y Q    DT     P  V+G
Sbjct: 438 NVIGPIQCEGLANLGVTQIACAEKRFLILSR-----NGRVYTQAYNSDTLA---PQLVQG 489

Query: 333 LSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL---- 494
           L++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+   +    
Sbjct: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEPKVISAF 544

Query: 495 ----AGEDIVQVSCGGTHSVVLTSDGRIFSY 575
               AG+ +V ++CG T+S  +T++G ++++
Sbjct: 545 SGKQAGKHVVHIACGSTYSAAITAEGELYTW 575



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 43/132 (32%), Positives = 65/132 (49%), Gaps = 6/132 (4%)
 Frame = +3

Query: 9    GRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRV 176
            G  +P+       L V +V  G   SV LT+ G V+TWG+        G   ++  P +V
Sbjct: 4184 GCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQV 4243

Query: 177  QGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL 350
            QGL+  +V  IA G+ H +  + D  ++ WG+N+ GQLG G T    +P  V  L    +
Sbjct: 4244 QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKV 4303

Query: 351  VDIAAGGWHSAA 386
              +A G  H+ A
Sbjct: 4304 NRVACGSAHTLA 4315



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 54/163 (33%)
 Frame = +3

Query: 249  LWAWGNNEYGQ------------------------------------------------- 281
            ++ WG+N  GQ                                                 
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4013

Query: 282  ---LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGF 446
               LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG 
Sbjct: 4014 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4073

Query: 447  GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            G ++S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4074 G-NRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4115

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>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  113 bits (282), Expect = 4e-25
 Identities = 69/196 (35%), Positives = 109/196 (55%), Gaps = 10/196 (5%)
 Frame = +3

Query: 18   IPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQGL 185
            +P   +   +L+   +A G     +++Q+G V+  G+        G   N+  P ++  L
Sbjct: 3009 VPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVL 3068

Query: 186  EQ--VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
             Q  V  +AV  G  H LAL++D  +++WG  E G+LG G+     +P  VE L    + 
Sbjct: 3069 RQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIR 3128

Query: 354  DIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG- 530
            D+A G  HSAA++ +GE+Y WG GE+GRLG GD+ ++ + P  V  LAG  +VQV+CG  
Sbjct: 3129 DVACGSSHSAAISSQGELYTWGLGEYGRLGHGDN-TTQLKPKLVTALAGRRVVQVACGSR 3187

Query: 531  -THSVVLTSDGRIFSY 575
               ++ LT DG +FS+
Sbjct: 3188 DAQTLALTEDGAVFSW 3203



 Score =  107 bits (267), Expect = 2e-23
 Identities = 59/184 (32%), Positives = 92/184 (50%), Gaps = 8/184 (4%)
 Frame = +3

Query: 48   LKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV-- 209
            + V  +A G  HS  +T  GHV TWG+        GD ++   P  V+ L     I +  
Sbjct: 4188 MSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIAC 4247

Query: 210  --GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSA 383
              G    L ++ D  +W+WG+ +YG+LG G +     P ++E L+ L +V +  G   S 
Sbjct: 4248 GSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSV 4307

Query: 384  ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
            ALTK G VY WG+G+  RLG G        P +V  L G+ I+ ++ G  H V  +  G 
Sbjct: 4308 ALTKSGAVYTWGKGDFHRLGHGSVDHVRR-PKKVAALQGKKIISIATGSLHCVACSDSGE 4366

Query: 564  IFSY 575
            ++++
Sbjct: 4367 VYTW 4370



 Score =  105 bits (261), Expect = 1e-22
 Identities = 59/183 (32%), Positives = 99/183 (54%), Gaps = 8/183 (4%)
 Frame = +3

Query: 51   KVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGL--EQVSMIAVG 212
            K+R VA G +HS  ++ +G ++TWG         GD      P  V  L   +V  +A G
Sbjct: 3126 KIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACG 3185

Query: 213  A--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAA 386
            +     LAL+ D  +++WG+ ++G+LG G ++    P  +E LS + +V I  G   S A
Sbjct: 3186 SRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLA 3245

Query: 387  LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 566
            LT+ GEV+ WG+G++ RLG G D+     P  +  L G  ++ V+ G  H + +T  G++
Sbjct: 3246 LTRAGEVWTWGKGDYYRLGHGGDQHVRK-PQPIGGLRGRRVIHVAVGALHCLAVTDAGQV 3304

Query: 567  FSY 575
            +++
Sbjct: 3305 YAW 3307



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 61/195 (31%), Positives = 97/195 (49%), Gaps = 10/195 (5%)
 Frame = +3

Query: 21   PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLE 188
            P P      L+  Q+A G      +T +G ++  G         G   + + P  +  L+
Sbjct: 4073 PTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQ 4132

Query: 189  QVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVD 356
             V +  V    G  H LAL+ +  ++AWG  E G+LG G+     +P  VE L+ +S+ D
Sbjct: 4133 HVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVAD 4192

Query: 357  IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG-- 530
            IA G  HSAA+T  G V  WG+G +GRLG GD +   + P  V+ L G   + ++CG   
Sbjct: 4193 IACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE-DQLRPKLVEALLGYRAIDIACGSGD 4251

Query: 531  THSVVLTSDGRIFSY 575
              ++ +T D  ++S+
Sbjct: 4252 AQTLCITDDDNVWSW 4266



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 57/185 (30%), Positives = 97/185 (52%), Gaps = 8/185 (4%)
 Frame = +3

Query: 45   KLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQVSMIAVGAF-- 218
            + +++QVA   T  ++L+QEG ++TW    P  +      P+ ++ +     I++     
Sbjct: 571  RFQIKQVACCETQMLILSQEGKLYTWRLAKPEAE------PLPMEEVAHDVFISIAGHCE 624

Query: 219  --HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
              H LA+  +   ++WG  E  +LG GDT  R+ P ++  L    +  +  G  +SAA+T
Sbjct: 625  GRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAIT 684

Query: 393  KEGEVYAWGRGEHGRLGFG--DDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDG 560
              G +  WGRG + RLG G  DD+S   +P  V  L+   +V V+ G    HS+ LTS+G
Sbjct: 685  CGGNLLTWGRGTYARLGHGNSDDRS---LPTLVVALSDHMVVDVALGSGDAHSLALTSEG 741

Query: 561  RIFSY 575
             +F++
Sbjct: 742  LVFAW 746



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 11/175 (6%)
 Frame = +3

Query: 51   KVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAV- 209
            +V QVA G     ++ LT++G V++WG         G  +   TP  ++ L  + ++ + 
Sbjct: 3178 RVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIE 3237

Query: 210  -GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAA 386
             GA  +LAL+    +W WG  +Y +LG G  Q   +P  + GL    ++ +A G  H  A
Sbjct: 3238 CGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLA 3297

Query: 387  LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV---QVSCGGTHSV 542
            +T  G+VYAWG  +HG+ G G+      V  +  L+ G D V   +V+CG +HS+
Sbjct: 3298 VTDAGQVYAWGDNDHGQQGSGNT----FVNKKPALVIGLDAVFVNRVACGSSHSI 3348



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 47/168 (27%), Positives = 85/168 (50%), Gaps = 6/168 (3%)
 Frame = +3

Query: 69   AGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAV--GAFHNLA 230
            +G   ++ +T + +VW+WG         G       P +++ L  + ++ V  G+  ++A
Sbjct: 4249 SGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVA 4308

Query: 231  LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVY 410
            L+    ++ WG  ++ +LG G      +P +V  L    ++ IA G  H  A +  GEVY
Sbjct: 4309 LTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVY 4368

Query: 411  AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
             WG  + G+LG G   ++   P  V  L G+ IV+V+CG  H++ L++
Sbjct: 4369 TWGDNDEGQLGDG-TVTAIQRPRLVAALQGKHIVKVTCGSAHTLALST 4415



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 58/183 (31%), Positives = 90/183 (49%), Gaps = 9/183 (4%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQGLEQVSMIAV---- 209
            V+ V  G ++S  +T  G++ TWG+        G+  + S P  V  L    ++ V    
Sbjct: 670  VQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGS 729

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
            G  H+LAL+ + +++AWG+ +YG+LG G+     QPI VE L  +  V   AG   S AL
Sbjct: 730  GDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRV--FAGSQFSVAL 787

Query: 390  TKEGEVYAWGRGE-HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 566
            + EG++Y WG+    G            VP  V  L  + IV V+    H + L+S G +
Sbjct: 788  SSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEV 847

Query: 567  FSY 575
            F +
Sbjct: 848  FGW 850



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 45/134 (33%), Positives = 69/134 (51%), Gaps = 6/134 (4%)
 Frame = +3

Query: 3    ARGRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPV 170
            + G D P        + V Q+  G   S+ LT+ G VWTWG+        G  +++  P 
Sbjct: 3216 SEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQ 3275

Query: 171  RVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 344
             + GL   +V  +AVGA H LA++    ++AWG+N++GQ G G+T    +P  V GL  +
Sbjct: 3276 PIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAV 3335

Query: 345  SLVDIAAGGWHSAA 386
             +  +A G  HS A
Sbjct: 3336 FVNRVACGSSHSIA 3349



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 41/128 (32%), Positives = 61/128 (47%), Gaps = 6/128 (4%)
 Frame = +3

Query: 63   VAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLA 230
            + +G  HS+ LT EG V+ WG         G+      P+ V+ L +V  +  G+  ++A
Sbjct: 727  LGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFAGSQFSVA 786

Query: 231  LSVDRILWAWGNNEY--GQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGE 404
            LS +  L+ WG       QL     Q  S P  V  L +  +VD+A    H  AL+  GE
Sbjct: 787  LSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGE 846

Query: 405  VYAWGRGE 428
            V+ WGR +
Sbjct: 847  VFGWGRND 854



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 2/111 (1%)
 Frame = +3

Query: 249  LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 428
            ++ WG+N  GQLG  +      P   E LS L  V +A G     A+T +G+++A G G 
Sbjct: 4051 IYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGS 4110

Query: 429  HGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSY 575
             GRLG G    S  +P  +  L    +  V V+ GG H + LT++G ++++
Sbjct: 4111 GGRLGVG-GSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAW 4160



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 28/86 (32%), Positives = 45/86 (52%), Gaps = 8/86 (9%)
 Frame = +3

Query: 51   KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPG------DIKNISTPVRVQGLE--QVSMIA 206
            +V++V AG   SV L+ EG ++TWG+    G       ++  S P  V  L+  ++  +A
Sbjct: 773  RVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVA 832

Query: 207  VGAFHNLALSVDRILWAWGNNEYGQL 284
            V   H LALS    ++ WG N+  Q+
Sbjct: 833  VSVAHCLALSSSGEVFGWGRNDSQQI 858

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>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  111 bits (278), Expect = 1e-24
 Identities = 63/190 (33%), Positives = 102/190 (53%), Gaps = 7/190 (3%)
 Frame = +3

Query: 27  PQRCAL--KLKVRQVAAGGTHSVVLTQEGHVWTWG--QPWPPGDIKNISTPVRVQGL--E 188
           PQ C       V++VA GG HSV L ++G V+T G       G  +  + P ++  L  +
Sbjct: 25  PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQ 84

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR-SQPIRVEGLSNLSLVDIAA 365
            +  +A G  H+LALS    L++WG    GQLG+  T+   + P  ++ L+  +++ ++ 
Sbjct: 85  HIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSC 144

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 545
           G WH  AL  +G+ + WG+  HG+LG G +  S   P +V+ L G  + QV+ GG HS  
Sbjct: 145 GNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 204

Query: 546 LTSDGRIFSY 575
           L+  G +F +
Sbjct: 205 LSLSGAVFGW 214



 Score =  104 bits (259), Expect = 2e-22
 Identities = 60/182 (32%), Positives = 99/182 (54%), Gaps = 8/182 (4%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQVSM--IAVG 212
           + QV+ G  H + L  +G  +TWG     Q     +  + ++P RV+ LE + +  +A G
Sbjct: 139 ILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG 198

Query: 213 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
             H+ ALS+   ++ WG N  GQLG+ D + R  P  V+ L    +V I+ G  H+A LT
Sbjct: 199 GAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLT 258

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV-LTSDGRIF 569
           K G V+ +G G  G+LG  D  +  + P +V  L G ++ Q++CG  H++  + S G I+
Sbjct: 259 KSGGVFTFGAGSCGQLGH-DSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIY 317

Query: 570 SY 575
           ++
Sbjct: 318 AF 319



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 7/116 (6%)
 Frame = +3

Query: 6   RGRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVR 173
           + R+ P   +     KV  ++ G  H+ VLT+ G V+T+G           + +   P R
Sbjct: 228 KDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRR 287

Query: 174 VQGL--EQVSMIAVGAFHNLA-LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 332
           V  L   +V+ IA G  H LA +    +++A+G    GQLG G T     P  V+G
Sbjct: 288 VLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  103 bits (258), Expect = 3e-22
 Identities = 64/184 (34%), Positives = 100/184 (54%), Gaps = 9/184 (4%)
 Frame = +3

Query: 51  KVRQVAAG-GTHSVVLTQEGHVWTWG----QPWPPGDIKNISTPVRVQ---GLEQVSMIA 206
           K+  ++ G G H V+ T +G V+TWG         G   +   P  +      +QV  +A
Sbjct: 99  KIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVA 158

Query: 207 VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSA 383
            G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +++IA G   S 
Sbjct: 159 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSM 218

Query: 384 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
           A+   GEVY WG   +G+LG G    +   P +V  L G  + +V+CG  H++VLT +G+
Sbjct: 219 AVVDTGEVYVWGYNGNGQLGLG-SSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQ 277

Query: 564 IFSY 575
           I+++
Sbjct: 278 IYAW 281



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 62/183 (33%), Positives = 90/183 (49%), Gaps = 8/183 (4%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQ---VSMIAV 209
           +V +VA G  HS+VLT +G V+ WG         G   N   P RV G  Q   V  IA 
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIAC 212

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G   ++A+     ++ WG N  GQLG+G +  +  P RV  L  + +  +A G  H+  L
Sbjct: 213 GQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVL 272

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRI 566
           T EG++YAWG   +G+LG G +KS+   P  V +     I   +C   H S   T  G +
Sbjct: 273 TDEGQIYAWGANSYGQLGTG-NKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHV 331

Query: 567 FSY 575
           + +
Sbjct: 332 YMW 334



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 42/147 (28%), Positives = 79/147 (53%), Gaps = 4/147 (2%)
 Frame = +3

Query: 141 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 311
           GDI++   P R+  L  ++++ ++ G+  ++ L+  D  ++ WG+N Y QLG G T    
Sbjct: 81  GDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 312 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTG 200

Query: 489 LLAGEDIVQVSCGGTHSVVLTSDGRIF 569
            L  + ++ ++CG   S+ +   G ++
Sbjct: 201 CLQNKVVMNIACGQMCSMAVVDTGEVY 227



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 45/150 (30%), Positives = 79/150 (52%), Gaps = 2/150 (1%)
 Frame = +3

Query: 132 WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
           WP   I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   
Sbjct: 31  WP---IFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTI 87

Query: 312 QPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
           +P R++ L+   +  ++ G G H    T +GEV+ WG   + +LG G      +VP  + 
Sbjct: 88  EPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHG-LVPCHIS 146

Query: 489 L-LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
             L+ + +++V+CG  HS+VLTSDG +F++
Sbjct: 147 TNLSNKQVIEVACGSYHSLVLTSDGEVFAW 176



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 51/145 (35%), Positives = 71/145 (48%), Gaps = 11/145 (7%)
 Frame = +3

Query: 21  PIPQR---CALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQ 179
           PIP+R   C     V  +A G   S+ +   G V+ WG         G   N  TP RV 
Sbjct: 193 PIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 252

Query: 180 GLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 253 ALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVV-VEKDRII 311

Query: 354 DIAA--GGWHSAALTKEGEVYAWGR 422
           +IAA      SAA T+ G VY WG+
Sbjct: 312 EIAACHSAHTSAAKTQGGHVYMWGQ 336

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  103 bits (257), Expect = 4e-22
 Identities = 64/184 (34%), Positives = 99/184 (53%), Gaps = 9/184 (4%)
 Frame = +3

Query: 51  KVRQVAAG-GTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQ---GLEQVSMIA 206
           K+  ++ G G H V+ T +G V+TWG         G   +   P  +      +QV  +A
Sbjct: 99  KIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVA 158

Query: 207 VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSA 383
            G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  ++ IA G   S 
Sbjct: 159 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSM 218

Query: 384 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
           A+   GEVY WG   +G+LG G    +   P +V  L G  + +V+CG  H++VLT +G+
Sbjct: 219 AVVDTGEVYVWGYNGNGQLGLGSS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQ 277

Query: 564 IFSY 575
           I+++
Sbjct: 278 IYAW 281



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 7/177 (3%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQ---VSMIAV 209
           +V +VA G  HS+VLT +G V+ WG         G   N   P RV G  Q   V  IA 
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIAC 212

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G   ++A+     ++ WG N  GQLG+G +  +  P RV  L  + +  +A G  H+  L
Sbjct: 213 GQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVL 272

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDG 560
           T EG++YAWG   +G+LG G +KS+   P  V +     I   +C   H+    S G
Sbjct: 273 TDEGQIYAWGANSYGQLGTG-NKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKSQG 328



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 42/147 (28%), Positives = 79/147 (53%), Gaps = 4/147 (2%)
 Frame = +3

Query: 141 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 311
           GDI++   P R+  L  ++++ ++ G+  ++ L+  D  ++ WG+N Y QLG G T    
Sbjct: 81  GDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 312 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTG 200

Query: 489 LLAGEDIVQVSCGGTHSVVLTSDGRIF 569
            L  + ++ ++CG   S+ +   G ++
Sbjct: 201 CLQNKVVMSIACGQMCSMAVVDTGEVY 227



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 45/150 (30%), Positives = 79/150 (52%), Gaps = 2/150 (1%)
 Frame = +3

Query: 132 WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
           WP   I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   
Sbjct: 31  WP---IFSLCSEEELQLIRQACVFGTAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTI 87

Query: 312 QPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
           +P R++ L+   +  ++ G G H    T +GEV+ WG   + +LG G      +VP  + 
Sbjct: 88  EPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHG-LVPCHIS 146

Query: 489 L-LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
             L+ + +++V+CG  HS+VLTSDG +F++
Sbjct: 147 TNLSNKQVIEVACGSYHSLVLTSDGEVFAW 176



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 50/145 (34%), Positives = 71/145 (48%), Gaps = 11/145 (7%)
 Frame = +3

Query: 21  PIPQR---CALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQ 179
           PIP+R   C     V  +A G   S+ +   G V+ WG         G   N  TP RV 
Sbjct: 193 PIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 252

Query: 180 GLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 253 ALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVV-VEKDRII 311

Query: 354 DIAA--GGWHSAALTKEGEVYAWGR 422
           +IAA      SAA ++ G VY WG+
Sbjct: 312 EIAACHSAHTSAAKSQGGHVYMWGQ 336

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score =  102 bits (255), Expect = 6e-22
 Identities = 62/175 (35%), Positives = 94/175 (53%), Gaps = 8/175 (4%)
 Frame = +3

Query: 75  GTHSVVLTQEGHVWTWG----QPWPPGDIKNISTPVRVQ---GLEQVSMIAVGAFHNLAL 233
           G H V+ T EG V+TWG         G   +   P  +      +QV  +A G++H+L L
Sbjct: 108 GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVL 167

Query: 234 SVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVY 410
           + D  ++AWG N  GQ+G G T  +  P RV G L N  +V IA G     A+   GEVY
Sbjct: 168 TSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVY 227

Query: 411 AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            WG   +G+LG G +  +   P +V  L G  + +V+CG  H++VLT +G+++++
Sbjct: 228 VWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAW 281



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 8/183 (4%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQ---VSMIAV 209
           +V +VA G  HS+VLT +G V+ WG         G   N   P RV G  Q   V  IA 
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G    +A+     ++ WG N  GQLG+G++  +  P RV  L  + +  +A G  H+  L
Sbjct: 213 GQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVL 272

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRI 566
           T EG+VYAWG   +G+LG G +KS+   P  V +     I   +C  TH S   T  G +
Sbjct: 273 TDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHV 331

Query: 567 FSY 575
           + +
Sbjct: 332 YMW 334



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 46/150 (30%), Positives = 79/150 (52%), Gaps = 2/150 (1%)
 Frame = +3

Query: 132 WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
           WP   I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   
Sbjct: 31  WP---IFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI 87

Query: 312 QPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
           +P R++ L+   +  ++ G G H    T EGEV+ WG   + +LG G      +VP  + 
Sbjct: 88  EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHG-LVPCHIS 146

Query: 489 L-LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
             L+ + +++V+CG  HS+VLTSDG +F++
Sbjct: 147 TNLSNKQVIEVACGSYHSLVLTSDGEVFAW 176



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 40/147 (27%), Positives = 78/147 (53%), Gaps = 4/147 (2%)
 Frame = +3

Query: 141 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 311
           GD+++   P R+  L  ++++ ++ G+  ++ L+  +  ++ WG+N Y QLG G T    
Sbjct: 81  GDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 312 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200

Query: 489 LLAGEDIVQVSCGGTHSVVLTSDGRIF 569
            L  + +V ++CG    + +   G ++
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVY 227



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 50/145 (34%), Positives = 71/145 (48%), Gaps = 11/145 (7%)
 Frame = +3

Query: 21  PIPQR---CALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQ 179
           PIP+R   C     V  +A G    + +   G V+ WG         G+  N  TP RV 
Sbjct: 193 PIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVA 252

Query: 180 GLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 253 ALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT-VEKDRII 311

Query: 354 DIAA--GGWHSAALTKEGEVYAWGR 422
           +IAA      SAA T+ G VY WG+
Sbjct: 312 EIAACHSTHTSAAKTQGGHVYMWGQ 336



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 37/134 (27%), Positives = 60/134 (44%), Gaps = 10/134 (7%)
 Frame = +3

Query: 21  PIPQRCALK--LKVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQG 182
           P P R A    ++V++VA G  H++VLT EG V+ WG         G+  N S P  V  
Sbjct: 246 PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT- 304

Query: 183 LEQVSMIAVGAFHNLALSVDRI----LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL 350
           +E+  +I + A H+   S  +     ++ WG            Q R Q + +  L++ S 
Sbjct: 305 VEKDRIIEIAACHSTHTSAAKTQGGHVYMWG------------QCRGQSVILPHLTHFSC 352

Query: 351 VDIAAGGWHSAALT 392
            D     + + A+T
Sbjct: 353 TDDVFACFATPAVT 366

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score =  102 bits (255), Expect = 6e-22
 Identities = 62/175 (35%), Positives = 94/175 (53%), Gaps = 8/175 (4%)
 Frame = +3

Query: 75  GTHSVVLTQEGHVWTWG----QPWPPGDIKNISTPVRVQ---GLEQVSMIAVGAFHNLAL 233
           G H V+ T EG V+TWG         G   +   P  +      +QV  +A G++H+L L
Sbjct: 108 GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVL 167

Query: 234 SVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVY 410
           + D  ++AWG N  GQ+G G T  +  P RV G L N  +V IA G     A+   GEVY
Sbjct: 168 TSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVY 227

Query: 411 AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            WG   +G+LG G +  +   P +V  L G  + +V+CG  H++VLT +G+++++
Sbjct: 228 VWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAW 281



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 8/183 (4%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQ---VSMIAV 209
           +V +VA G  HS+VLT +G V+ WG         G   N   P RV G  Q   V  IA 
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G    +A+     ++ WG N  GQLG+G++  +  P RV  L  + +  +A G  H+  L
Sbjct: 213 GQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVL 272

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRI 566
           T EG+VYAWG   +G+LG G +KS+   P  V +     I   +C  TH S   T  G +
Sbjct: 273 TDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHV 331

Query: 567 FSY 575
           + +
Sbjct: 332 YMW 334



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 46/150 (30%), Positives = 79/150 (52%), Gaps = 2/150 (1%)
 Frame = +3

Query: 132 WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
           WP   I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   
Sbjct: 31  WP---IFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI 87

Query: 312 QPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
           +P R++ L+   +  ++ G G H    T EGEV+ WG   + +LG G      +VP  + 
Sbjct: 88  EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHG-LVPCHIS 146

Query: 489 L-LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
             L+ + +++V+CG  HS+VLTSDG +F++
Sbjct: 147 TNLSNKQVIEVACGSYHSLVLTSDGEVFAW 176



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 40/147 (27%), Positives = 78/147 (53%), Gaps = 4/147 (2%)
 Frame = +3

Query: 141 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 311
           GD+++   P R+  L  ++++ ++ G+  ++ L+  +  ++ WG+N Y QLG G T    
Sbjct: 81  GDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 312 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200

Query: 489 LLAGEDIVQVSCGGTHSVVLTSDGRIF 569
            L  + +V ++CG    + +   G ++
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVY 227



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 50/145 (34%), Positives = 71/145 (48%), Gaps = 11/145 (7%)
 Frame = +3

Query: 21  PIPQR---CALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQ 179
           PIP+R   C     V  +A G    + +   G V+ WG         G+  N  TP RV 
Sbjct: 193 PIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVA 252

Query: 180 GLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 253 ALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT-VEKDRII 311

Query: 354 DIAA--GGWHSAALTKEGEVYAWGR 422
           +IAA      SAA T+ G VY WG+
Sbjct: 312 EIAACHSTHTSAAKTQGGHVYMWGQ 336



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 37/134 (27%), Positives = 60/134 (44%), Gaps = 10/134 (7%)
 Frame = +3

Query: 21  PIPQRCALK--LKVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQG 182
           P P R A    ++V++VA G  H++VLT EG V+ WG         G+  N S P  V  
Sbjct: 246 PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT- 304

Query: 183 LEQVSMIAVGAFHNLALSVDRI----LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL 350
           +E+  +I + A H+   S  +     ++ WG            Q R Q + +  L++ S 
Sbjct: 305 VEKDRIIEIAACHSTHTSAAKTQGGHVYMWG------------QCRGQSVILPHLTHFSC 352

Query: 351 VDIAAGGWHSAALT 392
            D     + + A+T
Sbjct: 353 TDDVFACFATPAVT 366

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score =  101 bits (251), Expect = 2e-21
 Identities = 61/184 (33%), Positives = 102/184 (55%), Gaps = 9/184 (4%)
 Frame = +3

Query: 51  KVRQVAAG-GTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQG---LEQVSMIA 206
           K++ ++ G G H ++ T++G V+ WG         G       PV+V     ++QV  +A
Sbjct: 75  KIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVA 134

Query: 207 VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSA 383
            G+ H++AL+ D  L+AWG N  GQ+G G T  +  P +V   L    +V+IA G   S 
Sbjct: 135 CGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSM 194

Query: 384 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
           A+   GEVY WG   +G+LG G++  + + P++V  L G  + Q+ CG  H++ LT +G 
Sbjct: 195 AVLDSGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGL 253

Query: 564 IFSY 575
           ++++
Sbjct: 254 LYAW 257



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 58/183 (31%), Positives = 91/183 (49%), Gaps = 8/183 (4%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGL---EQVSMIAV 209
           +V +VA G  HS+ L  +G ++ WG         G   N  TP +V      ++V  IA 
Sbjct: 129 QVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIAC 188

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G   ++A+     ++ WG N  GQLG+G+   +  P+RV  L  + +  I  G  H+ AL
Sbjct: 189 GQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLAL 248

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRI 566
           T EG +YAWG   +G+LG G  K++ + P Q+ +     I   +C  TH S   T  G +
Sbjct: 249 TDEGLLYAWGANTYGQLGTG-SKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHV 307

Query: 567 FSY 575
           + +
Sbjct: 308 YMW 310



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 51/145 (35%), Positives = 72/145 (49%), Gaps = 11/145 (7%)
 Frame = +3

Query: 21  PIPQR---CALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQ 179
           P P++   C    +V  +A G T S+ +   G V+ WG         G+  N  TPVRV 
Sbjct: 169 PTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVA 228

Query: 180 GLEQ--VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            L    V+ I  G  H LAL+ + +L+AWG N YGQLG G       P ++  +    ++
Sbjct: 229 ALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQIM-VEKERVI 287

Query: 354 DIAA--GGWHSAALTKEGEVYAWGR 422
           +IAA      SAA T+ G VY WG+
Sbjct: 288 EIAACHSTHTSAAKTQGGHVYMWGQ 312



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 21/64 (32%), Positives = 39/64 (60%), Gaps = 1/64 (1%)
 Frame = +3

Query: 387 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG-GTHSVVLTSDGR 563
           +T   EV+ +G      LG GD++S+ +VP +++ L G+ I  +S G G H ++ T DG 
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGV 95

Query: 564 IFSY 575
           ++++
Sbjct: 96  VYAW 99

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 64/190 (33%), Positives = 95/190 (50%), Gaps = 13/190 (6%)
 Frame = +3

Query: 42  LKLKVRQVAAGGTHSVVLTQEGHVWTWGQP--------WPPGDIKN-----ISTPVRVQG 182
           L  +V QVAAG T    +T+ G +  W  P          PG ++      +S  +  Q 
Sbjct: 336 LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQS 395

Query: 183 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 362
              +  +A G      L+   I+  +G+   G LG G+    SQP  VE L    +V +A
Sbjct: 396 GVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVA 455

Query: 363 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 542
            G  H  AL+ +GE++AWGRG+ GRLG G  + SH  P QV +  G++  +V CG   S+
Sbjct: 456 CGASHVLALSTDGELFAWGRGDGGRLGLG-TRESHNCPQQVPVAPGQEAQRVVCGIDSSM 514

Query: 543 VLTSDGRIFS 572
           +LTS GR+ +
Sbjct: 515 ILTSPGRVLA 524



 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 51/178 (28%), Positives = 85/178 (47%), Gaps = 20/178 (11%)
 Frame = +3

Query: 51   KVRQVAAGGTHSVVLTQEGHVWTWG----------------QPWPPGDIKNIS--TPVRV 176
            + ++V  G   S++LT  G V   G                +P P   ++     TP+  
Sbjct: 502  EAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGS 561

Query: 177  QGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL 350
              L+Q  ++ V  G  H+ A++     + +G+N++GQLG    +    P RV+GL  + +
Sbjct: 562  APLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKM 621

Query: 351  VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 524
            V +A G   + A+  EGEVY+WG+G  GRLG  D+ +    P+Q+       +  VSC
Sbjct: 622  VMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSC 679



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 54/193 (27%), Positives = 83/193 (43%), Gaps = 19/193 (9%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV--GA 215
           ++ VA G   +  LT  G + T+G         G++ +IS P  V+ L    M+ V  GA
Sbjct: 399 IKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGA 458

Query: 216 FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTK 395
            H LALS D  L+AWG  + G+LG+G  +  + P +V          +  G   S  LT 
Sbjct: 459 SHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTS 518

Query: 396 EGEVYAWGRGEHGRLGFGD-------------DKSSHMVPLQVQLLAGEDIVQVSCGGTH 536
            G V A G     +LG                +++    PL    L  E ++ V  G  H
Sbjct: 519 PGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAH 578

Query: 537 SVVLTSDGRIFSY 575
           S  +T+ G  +++
Sbjct: 579 SAAITASGDCYTF 591

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 58/184 (31%), Positives = 101/184 (54%), Gaps = 9/184 (4%)
 Frame = +3

Query: 51  KVRQVAAG-GTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQG---LEQVSMIA 206
           K++ ++ G G H ++ T++G V+ WG         G       PV+V     ++QV  +A
Sbjct: 75  KIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVA 134

Query: 207 VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS-LVDIAAGGWHSA 383
            G+ H++AL+ D  ++AWG N  GQ+G G T  +  P +V    ++  +V IA G   S 
Sbjct: 135 CGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSM 194

Query: 384 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 563
           A+   GEVY WG   +G+LG G++  + + P++V  L    + Q+ CG  H++ LT +G 
Sbjct: 195 AVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGL 253

Query: 564 IFSY 575
           ++++
Sbjct: 254 LYAW 257



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 58/184 (31%), Positives = 98/184 (53%), Gaps = 9/184 (4%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQG---LEQVSMIAV 209
           +V +VA G  HS+ L  +G V+ WG         G   N  TP +V     +++V  IA 
Sbjct: 129 QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G   ++A+  +  ++ WG N  GQLG+G+   +  P+RV  L ++ +  I  G  H+ AL
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248

Query: 390 TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV-SCGGTH-SVVLTSDGR 563
           T EG +YAWG   +G+LG G +K++ + P  + ++  E +V++ +C   H S   T  G 
Sbjct: 249 TDEGLLYAWGANTYGQLGTG-NKNNLLSPAHI-MVEKERVVEIAACHSAHTSAAKTQGGH 306

Query: 564 IFSY 575
           ++ +
Sbjct: 307 VYMW 310



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 52/145 (35%), Positives = 73/145 (50%), Gaps = 11/145 (7%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQV---AAGGTHSVVLTQEGHVWTWGQPWPP----GDIKNISTPVRVQ 179
           P P++    L +++V   A G T S+ +   G V+ WG         G+  N  TPVRV 
Sbjct: 169 PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVA 228

Query: 180 GLEQV--SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
            L  V  + I  G  H LAL+ + +L+AWG N YGQLG G+      P  +  +    +V
Sbjct: 229 ALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIM-VEKERVV 287

Query: 354 DIAA--GGWHSAALTKEGEVYAWGR 422
           +IAA      SAA T+ G VY WG+
Sbjct: 288 EIAACHSAHTSAAKTQGGHVYMWGQ 312



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 44/150 (29%), Positives = 76/150 (50%), Gaps = 2/150 (1%)
 Frame = +3

Query: 132 WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
           WP   I  + +P  +  + +  +    A   L ++ +  ++ +G N    LG GD Q   
Sbjct: 7   WP---IFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTL 63

Query: 312 QPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV- 485
            P ++EGL    +  ++ G G H    T++G VYAWG   + +LG G      + P+QV 
Sbjct: 64  VPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQG-IAPVQVC 122

Query: 486 QLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
             L  + +V+V+CG  HS+ L +DG +F++
Sbjct: 123 TNLLIKQVVEVACGSHHSMALAADGEVFAW 152

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 64/187 (34%), Positives = 91/187 (48%), Gaps = 13/187 (6%)
 Frame = +3

Query: 42  LKLKVRQVAAGGTHSVVLTQEGHVWTWGQP--------WPPGDIKN-----ISTPVRVQG 182
           L  +V QVAAG T    +T+ G +  W  P          PG ++      IS  +  Q 
Sbjct: 330 LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS 389

Query: 183 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 362
              +  +A G F    L+   I+  +G+   G LG G     SQP  VE L    +V +A
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVA 449

Query: 363 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 542
            G  H  AL+ E E++AWGRG+ GRLG G  + SH  P QV +  G++  +V CG   S+
Sbjct: 450 CGASHVLALSTERELFAWGRGDSGRLGLG-TRESHSCPQQVPMPPGQEAQRVVCGIDSSM 508

Query: 543 VLTSDGR 563
           +LT  G+
Sbjct: 509 ILTVPGQ 515



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 35/113 (30%), Positives = 60/113 (53%)
 Frame = +3

Query: 186 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 365
           E +  I +G  H+ A++     + +G+N++GQLG    +    P +V+GL  + +  +A 
Sbjct: 561 EPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVAC 620

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 524
           G   + A+  E EVY+WG+G  GRLG  D+ +    P+Q+       +  VSC
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 55/193 (28%), Positives = 84/193 (43%), Gaps = 19/193 (9%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV--GA 215
           ++ VA G   +  LT  G + T+G         G + +IS P  V+ L    M+ V  GA
Sbjct: 393 IKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGA 452

Query: 216 FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTK 395
            H LALS +R L+AWG  + G+LG+G  +  S P +V          +  G   S  LT 
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTV 512

Query: 396 EGEVYAWGRGEHGRLG-----FGDDKSSHM---VPLQVQLLAG-----EDIVQVSCGGTH 536
            G+  A G     +LG      G++   H      L   LL       E ++ +  G  H
Sbjct: 513 PGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAH 572

Query: 537 SVVLTSDGRIFSY 575
           S  +T+ G  +++
Sbjct: 573 SAAVTASGDCYTF 585

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 45/121 (37%), Positives = 74/121 (61%)
 Frame = +3

Query: 213 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
           A H+L ++ +  LW+WG NE GQLG GDT+    P  +EGLS+  +V  A G  H+ ALT
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           + G V+A+G  + G+LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S
Sbjct: 219 ETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYS 277

Query: 573 Y 575
           +
Sbjct: 278 F 278



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 68/225 (30%), Positives = 109/225 (48%), Gaps = 36/225 (16%)
 Frame = +3

Query: 9   GRDIPIPQR--CALKLKVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNIST 164
           G+++  P R  C   ++VR V +G    HS+++T EG +W+WG+        GD K +  
Sbjct: 133 GQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEA 192

Query: 165 PVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQPRSQPIRVE 329
           P  ++GL  E +   A G  H LAL+    ++A+G N+ GQLG+G   D  P    I   
Sbjct: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252

Query: 330 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD-----------KSSHMVP 476
           G     +  +A G   S  +  +G +Y++G  E+G+LG   D               +VP
Sbjct: 253 G---QPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309

Query: 477 LQV----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 575
            +V          Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSW 354



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 53/200 (26%), Positives = 88/200 (44%), Gaps = 32/200 (16%)
 Frame = +3

Query: 66  AAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQ-VSMIAVGAFHNL 227
           A G  H++ LT+ G V+ +G     Q         + +P ++    Q ++ +A GA  ++
Sbjct: 208 ACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM 267

Query: 228 ALSVDRILWAWGNNEYGQLGIG----------------DTQPRSQPIRVEG--------L 335
            +     L+++G  EYGQLG                  +  PR   I +E         +
Sbjct: 268 IMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPV 327

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDI 509
            N+ + D+A G  H+  L  +  V++WG G +GRLG  + K   MVP  V+L    G   
Sbjct: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMVPRLVKLFDFPGRGA 386

Query: 510 VQVSCGGTHSVVLTSDGRIF 569
            Q+  G T S  ++  G +F
Sbjct: 387 SQIYAGYTCSFAVSEVGGLF 406



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
 Frame = +3

Query: 60  QVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGL--EQVSMIAVGAFHNLAL 233
           Q+ AG T S  +++ G ++ WG      +  +   P  VQ L   ++  +A G   ++ +
Sbjct: 388 QIYAGYTCSFAVSEVGGLFFWGATNTSRE--STMYPKAVQDLCGWRIRSLACGK-SSIIV 444

Query: 234 SVDRILWAWGNNE-YGQLGIGDTQPRSQPI--RVEGLSNLSLVDIAAGGWHSAALTKE 398
           + D    +WG +  +G+LG GD +P+S      V+ L  +    +A G  HS  + ++
Sbjct: 445 AADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 49/131 (37%), Positives = 77/131 (58%), Gaps = 2/131 (1%)
 Frame = +3

Query: 189 QVSMIAVG--AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 362
           QVS +  G  A H+L ++ +  LW+WG N+ GQLG GDT+    P  +EGL    +V  A
Sbjct: 122 QVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAA 181

Query: 363 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 542
            G  H+ ALT+ G VY +G  + G+LG G+   + + P  +Q   G+ IV+V+CG   S+
Sbjct: 182 CGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAEFSM 240

Query: 543 VLTSDGRIFSY 575
           ++   G ++S+
Sbjct: 241 IVDCKGNLYSF 251



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 64/223 (28%), Positives = 110/223 (49%), Gaps = 34/223 (15%)
 Frame = +3

Query: 9   GRDIPIPQR--CALKLKVRQVAAG--GTHSVVLTQEGHVWTWGQ----PWPPGDIKNIST 164
           G+++  P R  C   ++V  V +G    HS+++T EG +W+WG+        GD K +  
Sbjct: 106 GQNLWGPHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEA 165

Query: 165 PVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGD-TQPRSQPIRVEGL 335
           P  ++GL  E +   A G  H LAL+ +  ++ +G N+ GQLG G+ T     P  ++  
Sbjct: 166 PKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQ-Y 224

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK-----------SSHMVPLQ 482
           +   +V +A G   S  +  +G +Y++G  E+G+LG   D               ++P +
Sbjct: 225 NGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRR 284

Query: 483 V----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 575
           V          Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 285 VAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSW 327



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 58/200 (29%), Positives = 88/200 (44%), Gaps = 32/200 (16%)
 Frame = +3

Query: 66  AAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQ-VSMIAVGAFHNL 227
           A G  H++ LT+ G V+T+G     Q         + +P  +Q   Q +  +A GA  ++
Sbjct: 181 ACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACGAEFSM 240

Query: 228 ALSVDRILWAWGNNEYGQLG-------IGDTQ---------PRSQPIRVEG--------L 335
            +     L+++G  EYGQLG       I   Q         PR   I +E         +
Sbjct: 241 IVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPV 300

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDI 509
            N+   D+A G  H+  L  +  V++WG G +GRLG  + K   MVP  V+L    G   
Sbjct: 301 PNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMVPRLVKLFDFPGRGA 359

Query: 510 VQVSCGGTHSVVLTSDGRIF 569
            Q+ CG   S  L+  G +F
Sbjct: 360 TQIYCGYQCSFALSEMGGLF 379



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 30/123 (24%), Positives = 55/123 (44%), Gaps = 10/123 (8%)
 Frame = +3

Query: 60  QVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIST-----PVRVQGL--EQVSMIAVGAF 218
           Q+  G   S  L++ G ++ WG       + N S      P  VQ L   ++  +A G  
Sbjct: 361 QIYCGYQCSFALSEMGGLFFWG-------VTNTSRESTMYPKAVQDLCGWKIRSLACGK- 412

Query: 219 HNLALSVDRILWAWGNNE-YGQLGIGDTQPRSQPI--RVEGLSNLSLVDIAAGGWHSAAL 389
            ++ ++ D    +WG +  +G+LG GD +P+S      V+ L  +    +  G  HS  +
Sbjct: 413 SSIIVAADDSTISWGPSPTFGELGYGDNKPKSSTTAQEVKTLDGVYSEQVVMGYSHSLVI 472

Query: 390 TKE 398
            ++
Sbjct: 473 ARQ 475

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
 Frame = +3

Query: 189 QVSMIAVG--AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 362
           QV  +A G  A H+L ++V+  LW+WG N+ GQLG GD +    P  +E L     V  A
Sbjct: 140 QVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAA 199

Query: 363 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 542
            G  H+ ALT+ G VYA+G  + G+LG G+   +   P Q+ L  G+ I +V+CG   S+
Sbjct: 200 CGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQI-LYNGQPITKVACGAEFSM 258

Query: 543 VLTSDGRIFSY 575
           ++   G ++S+
Sbjct: 259 IMDCKGNLYSF 269



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 64/225 (28%), Positives = 107/225 (47%), Gaps = 36/225 (16%)
 Frame = +3

Query: 9   GRDIPIPQR--CALKLKVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNIST 164
           G+++  P R  C   ++VR VA+G    HS+++T EG +W+WG+        GDIK I  
Sbjct: 124 GQNLWGPHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDV 183

Query: 165 PVRVQGLEQVSMI--AVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQPRSQPIRVE 329
           P  ++ L+    +  A G  H LAL+ +  ++A+G N+ GQLG+G   D  P    I   
Sbjct: 184 PKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYN 243

Query: 330 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD----KSSHMVPLQVQLLA 497
           G     +  +A G   S  +  +G +Y++G  E+G+LG   D      +  +    +L+A
Sbjct: 244 G---QPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIA 300

Query: 498 GEDIV-------------------QVSCGGTHSVVLTSDGRIFSY 575
               +                    ++CG  HS++L S  R+FS+
Sbjct: 301 RRIAIFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSW 345



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 56/201 (27%), Positives = 90/201 (44%), Gaps = 33/201 (16%)
 Frame = +3

Query: 66  AAGGTHSVVLTQEGHVWTWGQPWPPGDI----KNISTPVRVQGL---EQVSMIAVGAFHN 224
           A G  H++ LT+ G V+ +G+    G +    K  + P   Q L   + ++ +A GA  +
Sbjct: 199 ACGRNHTLALTENGSVYAFGEN-KMGQLGLGNKTDAVPSPAQILYNGQPITKVACGAEFS 257

Query: 225 LALSVDRILWAWGNNEYGQLGI---GDTQPRSQPIRVE---------------------G 332
           + +     L+++G  EYGQLG    G    R+Q I  +                      
Sbjct: 258 MIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQILP 317

Query: 333 LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGED 506
           + N+ + DIA G  HS  L  +  V++WG G +GRLG  + +   MVP  V+L    G  
Sbjct: 318 VPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQR-DEMVPRLVKLFDFPGRG 376

Query: 507 IVQVSCGGTHSVVLTSDGRIF 569
             Q+  G T S  ++  G +F
Sbjct: 377 AAQIYAGATCSFAVSEMGGLF 397



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 49/198 (24%), Positives = 80/198 (40%), Gaps = 15/198 (7%)
 Frame = +3

Query: 9   GRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG-------------QPWPPGDI 149
           G+ +P+P      + VR +A G  HS++L  +  V++WG                 P  +
Sbjct: 313 GQILPVPN-----VVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLV 367

Query: 150 KNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE 329
           K    P R       + I  GA  + A+S    L+ WG     +           P  V+
Sbjct: 368 KLFDFPGR-----GAAQIYAGATCSFAVSEMGGLFFWGATNTSR------DSTMYPKAVQ 416

Query: 330 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG-EHGRLGFGDDKS-SHMVPLQVQLLAGE 503
            L    +  +A G   S  +  +    +WG     G LG+GD+K+ S     +V+ L G 
Sbjct: 417 DLCGWKVRSLACGK-SSIIVAADESTISWGPSPTFGELGYGDNKAKSSTTAQEVKTLDGI 475

Query: 504 DIVQVSCGGTHSVVLTSD 557
              QV  G +H++V+  D
Sbjct: 476 YSDQVIMGNSHTLVVARD 493

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 62/201 (30%), Positives = 99/201 (49%), Gaps = 13/201 (6%)
 Frame = +3

Query: 9   GRDIPIPQRCA-LKLKVRQVAAGGTHSVVLTQEGHVWTW-------GQPWPPGDIKNIST 164
           G  I  P R   L  +V QV+ G T  + +T+ G + TW       G+P  PG ++ +  
Sbjct: 326 GSGISTPLRLPMLNTEVIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQP 385

Query: 165 PVRVQGLE-----QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE 329
               + LE      +  ++ G      L+   I+  +G+   G LG G+    +QP  VE
Sbjct: 386 QFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVE 445

Query: 330 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDI 509
            L    LV ++ G  H  A+T E EV++WGRG++GRLG    + SH  P QV L A  + 
Sbjct: 446 ALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLA-TQDSHNCPQQVSLPADFEA 504

Query: 510 VQVSCGGTHSVVLTSDGRIFS 572
            +V CG   S+++++  +I +
Sbjct: 505 QRVLCGVDCSMIMSTQHQILA 525



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 50/192 (26%), Positives = 91/192 (47%), Gaps = 20/192 (10%)
 Frame = +3

Query: 60   QVAAGGTHSVVLTQEGHVWTWGQP------WPPGDIKNISTPVRVQGLEQVSMIAVGAFH 221
            QV+ G +H + +T E  V++WG+           D  N    V +    +   +  G   
Sbjct: 454  QVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDC 513

Query: 222  NLALSVDRILWAWGNNEYGQLGI----GDTQPRS----------QPIRVEGLSNLSLVDI 359
            ++ +S    + A GNN + +LG+    G  +P S          Q ++   L+   +V I
Sbjct: 514  SMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYI 573

Query: 360  AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 539
              G  HS A+T++G+ + +G  +HG+LG    +SS  VP QV  L G  I   +CG   +
Sbjct: 574  DIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSR-VPYQVSGLQG--ITMAACGDAFT 630

Query: 540  VVLTSDGRIFSY 575
            + + ++G ++++
Sbjct: 631  LAIGAEGEVYTW 642



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 34/113 (30%), Positives = 60/113 (53%)
 Frame = +3

Query: 186 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 365
           E++  I +G  H++A++     + +G+N++GQLG    +    P +V GL  +++   A 
Sbjct: 568 EKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGITMA--AC 625

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 524
           G   + A+  EGEVY WG+G  GRLG  ++      P+Q+       +  V+C
Sbjct: 626 GDAFTLAIGAEGEVYTWGKGARGRLGRKEEDFGIPKPVQLDESHAFTVTSVAC 678



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 19/193 (9%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNISTPVRVQGLEQVSMIAV--GA 215
           ++ V+ G   +  LT  G + T+G         G+  +++ P  V+ L    ++ V  GA
Sbjct: 400 IKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGA 459

Query: 216 FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTK 395
            H LA++ +R +++WG  + G+LG+      + P +V   ++     +  G   S  ++ 
Sbjct: 460 SHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMST 519

Query: 396 EGEVYAWGRGEHGRLGF----GDDKSS--------HMVPL-QVQLLAGEDIVQVSCGGTH 536
           + ++ A G     +LG     G ++ S        H+  L Q   L  E IV +  G  H
Sbjct: 520 QHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAH 579

Query: 537 SVVLTSDGRIFSY 575
           SV +T  G+ F++
Sbjct: 580 SVAVTEKGQCFTF 592



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 5/84 (5%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDI-----KNISTPVRVQGLEQVSMIAVGA 215
           K+  +  G  HSV +T++G  +T+G     G +     ++   P +V GL+ ++M A G 
Sbjct: 569 KIVYIDIGTAHSVAVTEKGQCFTFGSN-QHGQLGCSHRRSSRVPYQVSGLQGITMAACGD 627

Query: 216 FHNLALSVDRILWAWGNNEYGQLG 287
              LA+  +  ++ WG    G+LG
Sbjct: 628 AFTLAIGAEGEVYTWGKGARGRLG 651

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 44/121 (36%), Positives = 73/121 (60%)
 Frame = +3

Query: 213 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
           A H+L ++ +  LW+WG NE GQLG GDT+    P  +E LS+ ++V  A G  H+ ALT
Sbjct: 157 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALT 216

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
             G V+A+G  + G+LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S
Sbjct: 217 DTGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMLMDCKGNLYS 275

Query: 573 Y 575
           +
Sbjct: 276 F 276



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 67/225 (29%), Positives = 109/225 (48%), Gaps = 36/225 (16%)
 Frame = +3

Query: 9   GRDIPIPQR--CALKLKVRQVAAGG--THSVVLTQEGHVWTWGQ----PWPPGDIKNIST 164
           G+++  P R  C   ++VR V +G    HS+++T EG +W+WG+        GD K +  
Sbjct: 131 GQNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEA 190

Query: 165 PVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQPRSQPIRVE 329
           P  ++ L  E + + A G  H LAL+    ++A+G N+ GQLG+G   D  P    I   
Sbjct: 191 PRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 250

Query: 330 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD-----------KSSHMVP 476
           G     +  +A G   S  +  +G +Y++G  E+G+LG   D               +VP
Sbjct: 251 G---QPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 307

Query: 477 LQV----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 575
            +V          Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 308 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSW 352



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 53/200 (26%), Positives = 87/200 (43%), Gaps = 32/200 (16%)
 Frame = +3

Query: 66  AAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQ-VSMIAVGAFHNL 227
           A G  H++ LT  G V+ +G     Q         + +P ++    Q ++ +A GA  ++
Sbjct: 206 ACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM 265

Query: 228 ALSVDRILWAWGNNEYGQLGIG----------------DTQPRSQPIRVEG--------L 335
            +     L+++G  EYGQLG                  +  PR   I +E         +
Sbjct: 266 LMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPV 325

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDI 509
            N+ + D+A G  H+  L  +  V++WG G +GRLG  + K   MVP  V+L    G   
Sbjct: 326 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMVPRLVKLFDFPGRGA 384

Query: 510 VQVSCGGTHSVVLTSDGRIF 569
            Q+  G T S  ++  G +F
Sbjct: 385 TQIYAGYTCSFAVSEVGGLF 404



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
 Frame = +3

Query: 60  QVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGL--EQVSMIAVGAFHNLAL 233
           Q+ AG T S  +++ G ++ WG      +  +   P  VQ L   ++  +A G   ++ +
Sbjct: 386 QIYAGYTCSFAVSEVGGLFFWGATNTSRE--STMYPKAVQDLCGWRIRSLACGK-SSIIV 442

Query: 234 SVDRILWAWGNNE-YGQLGIGDTQPRSQPI--RVEGLSNLSLVDIAAGGWHSAALTKE 398
           + D    +WG +  +G+LG GD +P+S      V+ L  +    +A G  HS  + ++
Sbjct: 443 AADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 500

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 11/176 (6%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQ-PWPPGDIKNI-STPVRVQGL--EQVSMIAVGAFH 221
           V Q A G  H V+LT++G V+++G  PW  G ++   S+P+    L  + V  +A G+FH
Sbjct: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVVTVATGSFH 102

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDTQ--PRSQPIRVEG-----LSNLSLVDIAAGGWHS 380
           + A++ + + + WG N  GQ  + + Q  P   P+ +       L  + ++ +A G  H+
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162

Query: 381 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            AL+   E++AWG G   +LG          P +V+ LAG  ++QV+CG  HS+ L
Sbjct: 163 LALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLAL 216



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 37/100 (37%), Positives = 58/100 (58%)
 Frame = +3

Query: 249 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 428
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG   
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 429 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            G+LG  D  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 588 FGQLGHSDFPTT--VPRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 17/142 (11%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQ----------------PWPPGDIK 152
           PI +   +   V  VA G  HS  +T  G  + WG+                P P     
Sbjct: 82  PILENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIAD 141

Query: 153 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVE 329
           + ++P+    + Q   +A G  H LALS+ R +WAWG     QLG+  T  P ++P +VE
Sbjct: 142 SEASPLLAVRILQ---LACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVE 196

Query: 330 GLSNLSLVDIAAGGWHSAALTK 395
            L+   ++ +A G +HS AL +
Sbjct: 197 HLAGRVVLQVACGAFHSLALVQ 218



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 22/58 (37%), Positives = 39/58 (67%)
 Frame = +3

Query: 402 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSW 583



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 39/130 (30%), Positives = 65/130 (50%), Gaps = 11/130 (8%)
 Frame = +3

Query: 33  RCALKLKVRQVAAGGTHS-----VVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGL 185
           R A ++K R V    T+S     ++ +    VWTWG+        GD+     P+ V+ L
Sbjct: 497 RKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL 556

Query: 186 E--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 359
           +  +V  +  G +H+LAL+    +++WG+N +GQLG  D  P + P   +  S   +  +
Sbjct: 557 DGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSV 615

Query: 360 AAGGWHSAAL 389
           AAG  +S  L
Sbjct: 616 AAGRDYSLFL 625



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 37/146 (25%), Positives = 67/146 (45%), Gaps = 8/146 (5%)
 Frame = +3

Query: 162 TPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 335
           TP R+ G   + V   A+G  H + L+ D  ++++G   + + G  +  P S PI    L
Sbjct: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP-SSPILENAL 88

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHMVPLQVQLLA 497
               +V +A G +HS A+T  G  Y WG    G+    + +         +   +   L 
Sbjct: 89  VGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148

Query: 498 GEDIVQVSCGGTHSVVLTSDGRIFSY 575
              I+Q++CG  H++ L+    I+++
Sbjct: 149 AVRILQLACGEEHTLALSISREIWAW 174



 Score = 32.7 bits (73), Expect = 0.76
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = +3

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 573 Y 575
           +
Sbjct: 65  F 65



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 18/59 (30%), Positives = 30/59 (50%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQVS 197
           P+  +C    +V  + AGG HS+ LT +  V++WG     G + +   P  V  L ++S
Sbjct: 550 PLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN-TFGQLGHSDFPTTVPRLAKIS 607

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 56/176 (31%), Positives = 94/176 (53%), Gaps = 11/176 (6%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQ-PWPPGDIKNI-STPVRVQGL--EQVSMIAVGAFH 221
           V Q A G  H V+LT++G V+++G  PW  G ++   S+P+    L  + V  +A G+FH
Sbjct: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDTQ--PRSQPIRVEG-----LSNLSLVDIAAGGWHS 380
           + A++ + + + WG N  GQ  + + Q  P   P+ +       L  + ++ +A G  H+
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162

Query: 381 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            AL+   E++AWG G   +LG          P +V+ LAG  ++QV+CG  HS+ L
Sbjct: 163 LALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLAL 216



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 36/100 (36%), Positives = 58/100 (58%)
 Frame = +3

Query: 249 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 428
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG   
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 429 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            G+LG  D  ++  VP   ++ +   +  ++ G  +S+ L
Sbjct: 588 FGQLGHSDFPTT--VPRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 17/142 (11%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQ----------------PWPPGDIK 152
           PI +   +   V  VA G  HS  +T  G  + WG+                P P     
Sbjct: 82  PILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIAD 141

Query: 153 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVE 329
           + ++P+    + Q   +A G  H LALS+ R +WAWG     QLG+  T  P ++P +VE
Sbjct: 142 SEASPLLAVRILQ---LACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVE 196

Query: 330 GLSNLSLVDIAAGGWHSAALTK 395
            L+   ++ +A G +HS AL +
Sbjct: 197 HLAGRVVLQVACGAFHSLALVQ 218



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 22/58 (37%), Positives = 39/58 (67%)
 Frame = +3

Query: 402 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSW 583



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 40/130 (30%), Positives = 65/130 (50%), Gaps = 11/130 (8%)
 Frame = +3

Query: 33  RCALKLKVRQVAAGGTHS-----VVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGL 185
           R A ++K R V    T+S     ++ +    VWTWG+        GD+     P+ V+ L
Sbjct: 497 RKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL 556

Query: 186 E--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 359
           +  +V  +  G +H+LAL+    +++WG+N +GQLG  D  P + P   +  S   +  I
Sbjct: 557 DGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSI 615

Query: 360 AAGGWHSAAL 389
           AAG  +S  L
Sbjct: 616 AAGRDYSLFL 625



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 36/146 (24%), Positives = 67/146 (45%), Gaps = 8/146 (5%)
 Frame = +3

Query: 162 TPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 335
           TP R+ G   + V   A+G  H + L+ D  ++++G   + + G  +  P S PI    L
Sbjct: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP-SSPILENAL 88

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHMVPLQVQLLA 497
               ++ +A G +HS A+T  G  Y WG    G+    + +         +   +   L 
Sbjct: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148

Query: 498 GEDIVQVSCGGTHSVVLTSDGRIFSY 575
              I+Q++CG  H++ L+    I+++
Sbjct: 149 AVRILQLACGEEHTLALSISREIWAW 174



 Score = 32.7 bits (73), Expect = 0.76
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = +3

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 573 Y 575
           +
Sbjct: 65  F 65



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 6/77 (7%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQVS- 197
           P+  +C    +V  + AGG HS+ LT +  V++WG     G + +   P  V  L ++S 
Sbjct: 550 PLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN-TFGQLGHSDFPTTVPRLAKISS 608

Query: 198 -----MIAVGAFHNLAL 233
                 IA G  ++L L
Sbjct: 609 ENGVWSIAAGRDYSLFL 625

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 52/189 (27%), Positives = 101/189 (53%), Gaps = 9/189 (4%)
 Frame = +3

Query: 15  DIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP------WPPGDIKNISTPVRV 176
           ++ IP    +   +  ++ G  HS  +T +G ++T+G+P       P   + N  +P RV
Sbjct: 179 NVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRV 238

Query: 177 QGL-EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSL 350
            G+ E+V  +A G  H + L+ +++++A+G  ++GQLG+G      S+P  +E + +  +
Sbjct: 239 LGIPERVIQVACGGGHTVVLT-EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKI 297

Query: 351 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCG 527
             I+ G  H+A +T+ G +Y +G G HG+LG G ++ ++   P          +  ++CG
Sbjct: 298 CHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACG 357

Query: 528 GTHSVVLTS 554
           G H +V  +
Sbjct: 358 GCHMLVFAT 366



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 52/180 (28%), Positives = 94/180 (52%), Gaps = 6/180 (3%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQPWPPG----DIKNISTPVRVQGLEQVSMIAVGAFH 221
           ++Q++AG   S  LT++G ++ WG          D  N+  P  V   + +S I+ G +H
Sbjct: 142 IKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKPISWISCGYYH 201

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDT--QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTK 395
           +  +++D  L+ +G  E G+LG+ +        P RV G+    ++ +A GG H+  LT 
Sbjct: 202 SAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPE-RVIQVACGGGHTVVLT- 259

Query: 396 EGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           E  VYA+G G+ G+LG G        P  ++ +  + I  +SCG  H+ ++T  G ++++
Sbjct: 260 EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTF 319



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 54/179 (30%), Positives = 94/179 (52%), Gaps = 8/179 (4%)
 Frame = +3

Query: 63  VAAGGTHSVVLTQEGHVW-----TWGQPWPPGDIKNISTPVRVQGL--EQVSMIAVGAFH 221
           ++ G  H+ ++T    ++      WGQ    G    I  P  ++ L  E+V + A G  H
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQ-LGLGSKAAIIKPTCIKALKPEKVKLAACGRNH 98

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIAAGGWHSAALTKE 398
            L  +    ++A G N  GQLG+GDT  R    ++   +    +  ++AG   SAALT++
Sbjct: 99  TLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTED 158

Query: 399 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           G+++ WG    G++G  +DKS+  +P +V +  G+ I  +SCG  HS  +T DG ++++
Sbjct: 159 GKLFMWGDNSEGQIGL-EDKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYTF 214

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 57/179 (31%), Positives = 96/179 (53%), Gaps = 8/179 (4%)
 Frame = +3

Query: 63  VAAGGTHSVVLTQEGHVW-----TWGQPWPPGDIKNISTPVRVQGL--EQVSMIAVGAFH 221
           ++ G  H+ V+T    ++      WGQ    G    +S P  V+ L  E+V   A G  H
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQ-LGLGSKSTVSKPTCVKALKPEKVKFAACGRNH 98

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL-SNLSLVDIAAGGWHSAALTKE 398
            L  +    ++A G N  GQLG+GDT+ RS    +    S   +  ++AG   SAALT++
Sbjct: 99  TLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTED 158

Query: 399 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           GE++ WG    G++G  ++ ++  VP QV +  G+ I  +SCG  HS  +T++G+++++
Sbjct: 159 GELFMWGDNSEGQIGL-ENVTNVCVPQQVTV--GKPISWISCGYYHSAFVTTEGQLYTF 214



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 49/181 (27%), Positives = 96/181 (53%), Gaps = 6/181 (3%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPG----DIKNISTPVRVQGLEQVSMIAVGAF 218
           K++Q++AG   S  LT++G ++ WG          ++ N+  P +V   + +S I+ G +
Sbjct: 141 KIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVTVGKPISWISCGYY 200

Query: 219 HNLALSVDRILWAWGNNEYGQLGIGDTQ--PRSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
           H+  ++ +  L+ +G  E G+LG+ +        P  V G+    +V +A GG H+  LT
Sbjct: 201 HSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPG-KVVQVACGGGHTVVLT 259

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           ++  VY +G G+ G+LG G       VP  ++ +  + I  ++CG  H+ ++T  G +++
Sbjct: 260 EKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYT 318

Query: 573 Y 575
           +
Sbjct: 319 F 319



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 53/189 (28%), Positives = 98/189 (51%), Gaps = 9/189 (4%)
 Frame = +3

Query: 15  DIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP------WPPGDIKNISTPVRV 176
           ++ +PQ+  +   +  ++ G  HS  +T EG ++T+G+P       P   + N   P  V
Sbjct: 179 NVCVPQQVTVGKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPV 238

Query: 177 QGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSL 350
            G+  +V  +A G  H + L+ ++ ++ +G  ++GQLG+G      S P  +E + +  +
Sbjct: 239 PGIPGKVVQVACGGGHTVVLT-EKAVYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKI 297

Query: 351 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCG 527
             IA G  H+A +T  G +Y +G G HG+LG G ++ ++  +P          +  VSCG
Sbjct: 298 SFIACGENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCG 357

Query: 528 GTHSVVLTS 554
           G H++V  +
Sbjct: 358 GCHTLVFAT 366



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 39/127 (30%), Positives = 62/127 (48%)
 Frame = +3

Query: 195 SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW 374
           + ++ G  H   ++ +  L+ +G+N +GQLG+G     S+P  V+ L    +   A G  
Sbjct: 38  TFLSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRN 97

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H+   T+ G+VYA G    G+LG GD +      L     +   I Q+S G   S  LT 
Sbjct: 98  HTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTE 157

Query: 555 DGRIFSY 575
           DG +F +
Sbjct: 158 DGELFMW 164

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 57/188 (30%), Positives = 95/188 (50%), Gaps = 14/188 (7%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTW----------GQPWPPGDIKNISTPVRVQGLE--QV 194
           + RQV AG  H  V+T E  ++TW          GQ    GD  +   P  V+ L+   V
Sbjct: 352 RARQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQ-LGHGDRASYRQPKHVEKLQGKSV 410

Query: 195 SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAG 368
             ++ G+   + ++ +  L+++G++ YG LG+  +      +P+ V+   N  +  ++ G
Sbjct: 411 QKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCG 470

Query: 369 GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
             H  ALT+   VY+WG GE+GRLG  D +     P +V++  G  IV V CG   S +L
Sbjct: 471 DSHIMALTRSKSVYSWGCGEYGRLGL-DSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLL 529

Query: 549 TSDGRIFS 572
           T  G++ +
Sbjct: 530 TLTGKVLA 537



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 51/194 (26%), Positives = 89/194 (45%), Gaps = 20/194 (10%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQPW------PPGDIKNISTPVRVQGL--EQVSMIAV 209
           V++V+ G   +V +T EG ++++G  +             +  P+ V     E V  ++ 
Sbjct: 410 VQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSC 469

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G  H +AL+  + +++WG  EYG+LG+        P +VE    L +V++  G   S  L
Sbjct: 470 GDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLL 529

Query: 390 TKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQVSCGGT 533
           T  G+V A G  EH +LG         + ++   VP    L     L+   I  +S G T
Sbjct: 530 TLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRT 589

Query: 534 HSVVLTSDGRIFSY 575
           H+  +   GR+ ++
Sbjct: 590 HTAAIDERGRLLTF 603



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 48/197 (24%), Positives = 94/197 (47%), Gaps = 23/197 (11%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDI--------KNISTPVRVQGLEQVSMIAV 209
            V QV+ G +H + LT+   V++WG     G+          ++ +P +V+    + ++ V
Sbjct: 464  VDQVSCGDSHIMALTRSKSVYSWGC----GEYGRLGLDSEDDVYSPQKVEVQRGLCIVNV 519

Query: 210  --GAFHNLALSVDRILWAWGNNEYGQLGIGDTQ------------PRSQPIRV-EGLSNL 344
              G+  +  L++   + A G NE+ +LG+                P +  + + + LS  
Sbjct: 520  CCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFY 579

Query: 345  SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 524
             +  I+ G  H+AA+ + G +  +G  + G+LG GD +    + L    L G+ +++VSC
Sbjct: 580  KIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSC 639

Query: 525  GGTHSVVLTSDGRIFSY 575
            G   +   T+D  IF++
Sbjct: 640  GDEFTTAATADNHIFAW 656



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 33/129 (25%), Positives = 60/129 (46%), Gaps = 9/129 (6%)
 Frame = +3

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 365
           ++  I+ G  H  A+     L  +G+N+ GQLG+GD +       + G L    ++ ++ 
Sbjct: 580 KIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSC 639

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGF--------GDDKSSHMVPLQVQLLAGEDIVQVS 521
           G   + A T +  ++AWG G +GRL           D  +S   P+   L     +  +S
Sbjct: 640 GDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPIFGSL---HHVTDLS 696

Query: 522 CGGTHSVVL 548
           C G H++++
Sbjct: 697 CRGWHTILI 705



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 14/130 (10%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKN---ISTPVRVQGLEQVSMIAV 209
           K+R ++ G TH+  + + G + T+G         GD +    I+      G +QV  ++ 
Sbjct: 580 KIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSC 639

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGI-------GDTQPRSQPIRVEGLSNLSLVDIAAG 368
           G     A + D  ++AWGN   G+L +       G     S P  + G S   + D++  
Sbjct: 640 GDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPIFG-SLHHVTDLSCR 698

Query: 369 GWHSAALTKE 398
           GWH+  + ++
Sbjct: 699 GWHTILIVEK 708

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 54/192 (28%), Positives = 100/192 (52%), Gaps = 9/192 (4%)
 Frame = +3

Query: 15  DIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP------WPPGDIKNISTPVRV 176
           ++ +PQ+  +   V  ++ G  HS  +T +G ++ +G+P       P   + N  TP  V
Sbjct: 179 NVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV 238

Query: 177 QGL-EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSL 350
             + E+V  +A G  H + L+ +  ++ +G  ++GQLG+G      S+P  +E + + ++
Sbjct: 239 SEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTI 297

Query: 351 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCG 527
             I+ G  H+A +T  G +Y +G G HG+LG G ++ ++H +P          +  V+CG
Sbjct: 298 SYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357

Query: 528 GTHSVVLTSDGR 563
           G H VV  +  R
Sbjct: 358 GCHMVVFAAPHR 369



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 58/179 (32%), Positives = 93/179 (51%), Gaps = 8/179 (4%)
 Frame = +3

Query: 63  VAAGGTHSVVLTQEGHVW-----TWGQPWPPGDIKNISTPVRVQGL--EQVSMIAVGAFH 221
           ++ G  HS V+T    ++      WGQ    G    IS P  V+ L  E+V + A G  H
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQ-LGLGSKSAISKPTCVKALKPEKVKLAACGRNH 98

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL-SNLSLVDIAAGGWHSAALTKE 398
            L  +    ++A G N  GQLG+GDT+ R+    +    S   +  ++AG   SAALT++
Sbjct: 99  TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158

Query: 399 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           G ++ WG    G++G   + S+  VP QV +  G+ +  +SCG  HS  +T+DG ++ +
Sbjct: 159 GRLFMWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVF 214



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 50/181 (27%), Positives = 94/181 (51%), Gaps = 6/181 (3%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPG----DIKNISTPVRVQGLEQVSMIAVGAF 218
           K++Q++AG   S  LT++G ++ WG          ++ N+  P +V   + VS I+ G +
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200

Query: 219 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALT 392
           H+  ++ D  L+ +G  E G+LG+ +    +   P  V  +    ++ +A GG H+  LT
Sbjct: 201 HSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLT 259

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
            E  VY +G G+ G+LG G        P  ++ +  + I  +SCG  H+ ++T  G +++
Sbjct: 260 -ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYT 318

Query: 573 Y 575
           +
Sbjct: 319 F 319



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 24/74 (32%), Positives = 40/74 (54%)
 Frame = +3

Query: 351 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 530
           V ++ G  HSA +T   ++Y +G    G+LG G  KS+   P  V+ L  E +   +CG 
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAACGR 96

Query: 531 THSVVLTSDGRIFS 572
            H++V T  G +++
Sbjct: 97  NHTLVSTEGGNVYA 110

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 54/198 (27%), Positives = 96/198 (48%), Gaps = 23/198 (11%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGL-------EQVSMIAV 209
           ++ Q+A G  H + LT  G V+TWG        + +    R+QGL       + +  +  
Sbjct: 227 EICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVGA 286

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR-----SQPIRVEGLSNLSLVDIAAGGW 374
           G++H+ A+     ++AWG N   Q GI           ++P  V+ L   ++  I  G  
Sbjct: 287 GSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEH 346

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGD----------DKSSHMVPLQVQLLAG-EDIVQVS 521
           H+ AL ++G V AWGR +  +LG  D          +K ++       ++ G  +++QV 
Sbjct: 347 HTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVV 406

Query: 522 CGGTHSVVLTSDGRIFSY 575
           CG  H++ +TSDG+++S+
Sbjct: 407 CGTHHNLAVTSDGKVYSW 424



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 61/202 (30%), Positives = 91/202 (45%), Gaps = 29/202 (14%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG-----------QPWPPGDIKNISTPVR 173
           PQ  ALK  +  V AG  HS  +  +G V+ WG           +    G +  I+ P  
Sbjct: 273 PQPLALK-NIISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAV--ITKPTL 329

Query: 174 VQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI--------------GDTQP 305
           V  LE   V  I  G  H LAL  D  + AWG ++  QLGI              G+   
Sbjct: 330 VDALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYY 389

Query: 306 RSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV 485
            S P  + GL+N+  + +  G  H+ A+T +G+VY+WG  E+  +G GD+     VP  V
Sbjct: 390 LSTPTIIPGLTNV--IQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLV 447

Query: 486 QLLAGEDIV--QVSCGGTHSVV 545
           +  A +++       GG  S++
Sbjct: 448 RSKAIKEVAIRVAGAGGQFSII 469



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 48/188 (25%), Positives = 91/188 (48%), Gaps = 12/188 (6%)
 Frame = +3

Query: 48  LKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDI-------KNISTPVRVQGLEQVSMIA 206
           L+V +V      +  +T  G  +TWG       +       K  + P +++ L ++  +A
Sbjct: 174 LRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMR-LPEICQLA 232

Query: 207 VGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS-QPIRVEGLSNLSLVDIAAGGWHSA 383
            G  H +AL+    ++ WGN +  QLG    + R  Q +  + L+  +++ + AG +HS 
Sbjct: 233 TGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVGAGSYHSF 292

Query: 384 ALTKEGEVYAWGRGEHGRLGF--GDDKSSHMV--PLQVQLLAGEDIVQVSCGGTHSVVLT 551
           A+  +G VYAWG     + G    D++   ++  P  V  L G ++  ++ G  H++ L 
Sbjct: 293 AIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALL 352

Query: 552 SDGRIFSY 575
            DGR+ ++
Sbjct: 353 EDGRVLAW 360



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 60/199 (30%), Positives = 92/199 (46%), Gaps = 22/199 (11%)
 Frame = +3

Query: 45  KLKVRQVAAGGTHSVVLTQEGHVWTWG-------------QPWPPGD-IKNI---STPVR 173
           K+ V  +A GG HS  L+ +G V+TWG             Q    GD + N     TP +
Sbjct: 107 KVGVVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSK 166

Query: 174 VQG-LEQVSMIAVGAFHNL--ALSVDRILWAWGNNEY--GQLGIGDTQPRSQPIRVEGLS 338
           V+G L  + +  V    NL  A++ +   + WG      G LG  D+Q R+       L 
Sbjct: 167 VEGALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLP 226

Query: 339 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV 518
            +    +A G  H  ALT  G+VY WG G+  +LG    +   +  L  Q LA ++I+ V
Sbjct: 227 EIC--QLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISV 284

Query: 519 SCGGTHSVVLTSDGRIFSY 575
             G  HS  + + GR++++
Sbjct: 285 GAGSYHSFAIDNKGRVYAW 303

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 54/176 (30%), Positives = 90/176 (51%), Gaps = 11/176 (6%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQ-PWPPGDIKNI-STPVRVQGL--EQVSMIAVGAFH 221
           V Q A G  H V+LT++G V+++G  PW     +   S+P+    L    V  +A G+FH
Sbjct: 43  VLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEICPSSPLLESALVGHHVITVATGSFH 102

Query: 222 NLALSVDRILWAWGNNEYGQLGIGDTQ--PRSQPIRVEGLSN-----LSLVDIAAGGWHS 380
           + A++   +++ WG N  GQ  + + Q  P   P+ +          + ++ +A G  H+
Sbjct: 103 SGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLAVRILQLACGEEHT 162

Query: 381 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            AL+   E++AWG G   +LG          P +V+ LAG  ++QV+CG  HS+ L
Sbjct: 163 LALSLSREIWAWGTG--CQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLAL 216



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 36/100 (36%), Positives = 57/100 (57%)
 Frame = +3

Query: 249 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 428
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG HS ALT + +VY+WG   
Sbjct: 522 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNT 581

Query: 429 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            G+LG  +  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 582 FGQLGHSEFPTT--VPRLSKVSSENGVWSVAAGQDYSLFL 619



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 45/141 (31%), Positives = 68/141 (48%), Gaps = 16/141 (11%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQ--------------PWP-PGDIKN 155
           P+ +   +   V  VA G  HS  +T+ G V+ WG+              P P P  I +
Sbjct: 82  PLLESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISD 141

Query: 156 ISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG-IGDTQPRSQPIRVEG 332
             T   +    ++  +A G  H LALS+ R +WAWG     QLG I  T P ++P +VE 
Sbjct: 142 SETSPSLA--VRILQLACGEEHTLALSLSREIWAWGTG--CQLGLITTTFPVTKPQKVEH 197

Query: 333 LSNLSLVDIAAGGWHSAALTK 395
           L+   ++ +A G +HS AL +
Sbjct: 198 LAGRVVLQVACGAFHSLALVQ 218



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 22/58 (37%), Positives = 40/58 (68%)
 Frame = +3

Query: 402 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG+HS+ LT+  +++S+
Sbjct: 521 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSW 577



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 37/147 (25%), Positives = 68/147 (46%), Gaps = 9/147 (6%)
 Frame = +3

Query: 162 TPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 335
           TP R+ G   + V   A+G  H + L+ D  ++++G   +      +  P S P+    L
Sbjct: 31  TPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSES-AEICP-SSPLLESAL 88

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED--- 506
               ++ +A G +HS A+T+ G VY WG    G+    + +     P  V +   E    
Sbjct: 89  VGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYV-PEPSPVSISDSETSPS 147

Query: 507 ----IVQVSCGGTHSVVLTSDGRIFSY 575
               I+Q++CG  H++ L+    I+++
Sbjct: 148 LAVRILQLACGEEHTLALSLSREIWAW 174



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 39/129 (30%), Positives = 61/129 (47%), Gaps = 11/129 (8%)
 Frame = +3

Query: 33  RCALKLKVRQVAAGGTHS-----VVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGL 185
           R A ++K R V    T+S     ++ +    VWTWG+        GD+     P+ V+ L
Sbjct: 491 RKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCL 550

Query: 186 E--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 359
           +  +V  +  G  H+LAL+    +++WG+N +GQLG  +  P + P        LS V  
Sbjct: 551 DGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEF-PTTVP-------RLSKVSS 602

Query: 360 AAGGWHSAA 386
             G W  AA
Sbjct: 603 ENGVWSVAA 611



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 19/59 (32%), Positives = 31/59 (52%)
 Frame = +3

Query: 21  PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQVS 197
           P+  +C    +V  + AGG+HS+ LT +  V++WG     G + +   P  V  L +VS
Sbjct: 544 PLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSN-TFGQLGHSEFPTTVPRLSKVS 601



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 17/61 (27%), Positives = 30/61 (49%)
 Frame = +3

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           K+    A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KKSSTEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYS 64

Query: 573 Y 575
           +
Sbjct: 65  F 65

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 61/191 (31%), Positives = 94/191 (49%), Gaps = 17/191 (8%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWT-----WGQPWPPGDIKNISTPVRVQGL-EQVSMIAVGA 215
           +RQVA G   +++LT++G V +     +GQ   P   +    P  ++ L E+V  +A G 
Sbjct: 103 IRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAAGL 162

Query: 216 FHNLALSVDRILWAWGN---NEYGQLGIGDTQP----RSQPIRVEGLSNLSLVDIAAGGW 374
            H LA +    ++ WG    +   +L  G   P      +P RV GL N + V   AG  
Sbjct: 163 RHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSD 222

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA----GEDIVQVSCGGTHSV 542
           HSA+LT  GE+Y WGR +HG+L       +  +PL  ++ A     E +  V  G TH V
Sbjct: 223 HSASLTDTGELYVWGRNKHGQLA----SRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLV 278

Query: 543 VLTSDGRIFSY 575
             T  G++F++
Sbjct: 279 AKTETGKVFTW 289



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 60/214 (28%), Positives = 92/214 (42%), Gaps = 32/214 (14%)
 Frame = +3

Query: 12  RDIPIPQRC-ALKLKVRQVAAGGTHSVVLTQEGHVWTW-------GQPWPPGD----IKN 155
           R   +PQ    L+ KV  VAAG  H++  T  G V+ W       G+   PG        
Sbjct: 140 RKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLT 199

Query: 156 ISTPVRVQGLEQVSMI--AVGAFHNLALSVDRILWAWGNNEYGQLGIGDT-QPRSQPIRV 326
              P RV GLE  + +    G+ H+ +L+    L+ WG N++GQL       P  Q I  
Sbjct: 200 AKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEA 259

Query: 327 EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG-----------FGDDKS---- 461
               +  +  + +G  H  A T+ G+V+ WGR ++G+LG              D S    
Sbjct: 260 HYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQ 319

Query: 462 --SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 557
              + VP  +  L G    ++SCG  H++ +  D
Sbjct: 320 GPQNSVPSPLHCLTG--ATEISCGSEHNLAVIRD 351



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 36/115 (31%), Positives = 60/115 (52%), Gaps = 1/115 (0%)
 Frame = +3

Query: 231 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIAAGGWHSAALTKEGEV 407
           +S   +L+AWG N YGQLG+G  +    P ++        +  +  GG HSA +T  G++
Sbjct: 11  VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDL 70

Query: 408 YAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           +  G  + G+LG G  +      +  + L G  I QV+CG   +++LT  G++ S
Sbjct: 71  FVCGLNKDGQLGLGHTEEVLRFTI-CKPLRGCPIRQVACGWDFTIMLTEKGQVLS 124



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 49/186 (26%), Positives = 83/186 (44%), Gaps = 26/186 (13%)
 Frame = +3

Query: 69  AGGTHSVVLTQEGHVWTWGQPWPPGDIKN----ISTPVRVQGL----EQVSMIAVGAFHN 224
           AG  HS  LT  G ++ WG+    G + +    +  P R++      E+V+ +  G  H 
Sbjct: 219 AGSDHSASLTDTGELYVWGRN-KHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHL 277

Query: 225 LALSVDRILWAWGNNEYGQLGIGDTQPRSQ-------PIRVEGLSN---------LSLVD 356
           +A +    ++ WG  +YGQLG     P +Q        +  +G  N             +
Sbjct: 278 VAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTGATE 337

Query: 357 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL--AGEDIVQVSCGG 530
           I+ G  H+ A+ ++ +  +WG  EHG  G G + S+   P  VQ L  +   ++ V CG 
Sbjct: 338 ISCGSEHNLAVIRD-KCCSWGWNEHGMCGDGTE-SNVWTPTPVQALPPSPSRLLLVGCGA 395

Query: 531 THSVVL 548
            HS+ +
Sbjct: 396 GHSLAV 401



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 33/128 (25%), Positives = 62/128 (48%)
 Frame = +3

Query: 192 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 371
           +  +  G  H+  ++    L+  G N+ GQLG+G T+   +    + L    +  +A G 
Sbjct: 51  IKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGW 110

Query: 372 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 551
             +  LT++G+V + G    G+LG        +VP  ++ L  E +V V+ G  H++  T
Sbjct: 111 DFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLR-EKVVCVAAGLRHALATT 169

Query: 552 SDGRIFSY 575
           + G +F +
Sbjct: 170 ATGSVFQW 177



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 54/190 (28%), Positives = 79/190 (41%), Gaps = 18/190 (9%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIK----------NISTPVRVQGLEQVSMI 203
           ++ V  GG HS V+T  G ++  G     G +            I  P+R   + QV   
Sbjct: 51  IKSVTGGGGHSAVVTDGGDLFVCGLN-KDGQLGLGHTEEVLRFTICKPLRGCPIRQV--- 106

Query: 204 AVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGWH 377
           A G    + L+    + + G+N +GQLG+    PR    P  +E L    +V +AAG  H
Sbjct: 107 ACGWDFTIMLTEKGQVLSCGSNAFGQLGV-PHGPRKCVVPQAIECLRE-KVVCVAAGLRH 164

Query: 378 SAALTKEGEVYAWGRG---EHGRLGFGDDKSSHMV---PLQVQLLAGEDIVQVSCGGTHS 539
           + A T  G V+ WG G      RL  G +    +    P +V  L     V    G  HS
Sbjct: 165 ALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHS 224

Query: 540 VVLTSDGRIF 569
             LT  G ++
Sbjct: 225 ASLTDTGELY 234



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
 Frame = +3

Query: 378 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC------GGTHS 539
           S  ++    ++AWG   +G+LG G  K    +P Q+      D  Q  C      GG HS
Sbjct: 8   SETVSAAAVLFAWGANSYGQLGLG-HKEDVFLPQQL-----SDFCQAGCIKSVTGGGGHS 61

Query: 540 VVLTSDGRIF 569
            V+T  G +F
Sbjct: 62  AVVTDGGDLF 71

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 62/204 (30%), Positives = 97/204 (47%), Gaps = 17/204 (8%)
 Frame = +3

Query: 15  DIPI--PQRCALKLKVRQVAAGGTHSVVLTQEGHVWT-----WGQPWPPGDIKNISTPVR 173
           DIP   P +      ++QVA G   +++LT+ G V +     +GQ   P   +    P  
Sbjct: 88  DIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQA 147

Query: 174 VQ-GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYG---QLGIGDTQP----RSQPIRVE 329
           ++   E+V  IA G  H +A +   I++ WG        +L  G T P      +P RV 
Sbjct: 148 IELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVT 207

Query: 330 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVP--LQVQLLAGE 503
           GL N   + + AG  HSA+LT  GEVY WG  +HG+L   ++ +   VP  ++      E
Sbjct: 208 GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL--ANEAAFLPVPQKIEAHCFQNE 265

Query: 504 DIVQVSCGGTHSVVLTSDGRIFSY 575
            +  +  G TH V  T  G++F++
Sbjct: 266 KVTAIWSGWTHLVAQTETGKMFTW 289



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
 Frame = +3

Query: 249 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN-LSLVDIAAGGWHSAALTKEGEVYAWGRG 425
           L+AWG N YGQLG+G  +    P ++       S+  I  GG HSA +T  G+++  G  
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76

Query: 426 EHGRLGFGDDKS-SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           + G+LG G  +   +  P   + L G  I QV+CG   +++LT +G++ S
Sbjct: 77  KDGQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLS 124



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 54/192 (28%), Positives = 80/192 (41%), Gaps = 26/192 (13%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKN----ISTPVRVQGL----EQVSMIA 206
           K   V AG  HS  LT  G V+ WG     G + N    +  P +++      E+V+ I 
Sbjct: 213 KAMCVLAGSDHSASLTDAGEVYVWGSN-KHGQLANEAAFLPVPQKIEAHCFQNEKVTAIW 271

Query: 207 VGAFHNLALSVDRILWAWGNNEYGQLGIG------------------DTQPRSQPIRVEG 332
            G  H +A +    ++ WG  +YGQLG                       P S P     
Sbjct: 272 SGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHC 331

Query: 333 LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 512
           L+  +  +++ G  H+ A+   G  Y+WG  EHG  G G + ++   P  VQ L     +
Sbjct: 332 LTGAT--EVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTE-ANVWAPKPVQALLSSSGL 387

Query: 513 QVSCGGTHSVVL 548
            V CG  HS+ L
Sbjct: 388 LVGCGAGHSLAL 399



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 44/155 (28%), Positives = 68/155 (43%), Gaps = 31/155 (20%)
 Frame = +3

Query: 18  IPIPQR----CALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP--------------W--- 134
           +P+PQ+    C    KV  + +G TH V  T+ G ++TWG+               W   
Sbjct: 251 LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLE 310

Query: 135 ----------PPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQL 284
                     PP  +   S+P  + G  +VS    G+ HNLA+ +  + ++WG NE+G  
Sbjct: 311 KQDSFLPCSRPPNSMP--SSPHCLTGATEVSC---GSEHNLAI-IGGVCYSWGWNEHGMC 364

Query: 285 GIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
           G G       P  V+ L + S + +  G  HS AL
Sbjct: 365 GDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 55/200 (27%), Positives = 84/200 (42%), Gaps = 15/200 (7%)
 Frame = +3

Query: 15  DIPIPQRCALKLK---VRQVAAGGTHSVVLTQEGHVWTWG----QPWPPGDIKNIS--TP 167
           D+ +PQ+     K   VR++  GG HS V+T  G ++  G         G  ++I   TP
Sbjct: 35  DVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTP 94

Query: 168 VRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS 347
            +      +  +A G    + L+ +  + + G+N +GQLG+     R    +   L    
Sbjct: 95  CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEK 154

Query: 348 LVDIAAGGWHSAALTKEGEVYAWGRGEHG---RLGFGDDKSSHMV---PLQVQLLAGEDI 509
           +V IAAG  H+ A T  G V+ WG G      RL  G           P +V  L     
Sbjct: 155 VVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKA 214

Query: 510 VQVSCGGTHSVVLTSDGRIF 569
           + V  G  HS  LT  G ++
Sbjct: 215 MCVLAGSDHSASLTDAGEVY 234



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 35/128 (27%), Positives = 60/128 (46%)
 Frame = +3

Query: 192 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 371
           V  I  G  H+  ++    L+  G N+ GQLG+G T+        + L    +  +A G 
Sbjct: 51  VRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGW 110

Query: 372 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 551
             +  LT+ G+V + G    G+LG        +VP  ++ L  E +V ++ G  H+V  T
Sbjct: 111 DFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAAT 169

Query: 552 SDGRIFSY 575
           + G +F +
Sbjct: 170 ASGIVFQW 177



 Score = 36.6 bits (83), Expect = 0.053
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
 Frame = +3

Query: 378 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTS 554
           S A      ++AWG   +G+LG G  K   ++P Q+        + +++ GG HS V+T 
Sbjct: 8   SEAAPAAAALFAWGANSYGQLGLG-HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTD 66

Query: 555 DGRIF 569
            G +F
Sbjct: 67  GGDLF 71

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 53/186 (28%), Positives = 92/186 (49%), Gaps = 14/186 (7%)
 Frame = +3

Query: 57  RQVAAGGTHSVVLTQEGHVWTW----------GQPWPPGDIKNISTPVRVQGLE--QVSM 200
           RQV AG TH  V+T E  ++TW          GQ    GD  +   P  V+ L+   +  
Sbjct: 372 RQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQ-LGHGDKASYRQPKHVEKLQGKAIHQ 430

Query: 201 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGW 374
           ++ G    + ++ +  L+A+G++ YG +G+         +P+++    +  +  ++ G  
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDN 490

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H   LT+  EVY+WG GE+GRLG  D +  +  P +V +     IV V CG   + +LT 
Sbjct: 491 HVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQ 549

Query: 555 DGRIFS 572
            G++ +
Sbjct: 550 SGKVLA 555



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 50/175 (28%), Positives = 85/175 (48%), Gaps = 11/175 (6%)
 Frame = +3

Query: 84  SVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQ---VSMIAVGAFHNLALSVDRILW 254
           +VV ++   V+ WG           STP ++  ++       +  G  H   ++V++ L+
Sbjct: 340 AVVTSRTSEVYVWGG--------GKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELY 391

Query: 255 AWGNNE-----YGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG 419
            W N +     +GQLG GD     QP  VE L   ++  ++ G   +  +T EG++YA+G
Sbjct: 392 TWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFG 451

Query: 420 RGEHGRLGFGDDKSSH---MVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
              +G +G   DK S    + P+Q+       + QVSCG  H VVLT +  ++S+
Sbjct: 452 SDYYGCMGV--DKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 56/208 (26%), Positives = 93/208 (44%), Gaps = 23/208 (11%)
 Frame = +3

Query: 21   PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIS--------TPVRV 176
            P+     L   V QV+ G  H VVLT+   V++WG     G+   +         TP RV
Sbjct: 471  PMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWG----CGEYGRLGLDSEEDYYTPQRV 526

Query: 177  QGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQ------------PRSQ 314
               + + ++AV  G      L+    + A G NE+ +LG+                P + 
Sbjct: 527  DVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTT 586

Query: 315  PIRV-EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 491
               + + LS   +  IA G  H+AA+ + G +  +G  + G+LG G+ K    + L    
Sbjct: 587  SFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGP 646

Query: 492  LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            L G+ +++VSCG   ++  T D  IF++
Sbjct: 647  LGGKQVIRVSCGDEFTIAATDDNHIFAW 674



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 46/194 (23%), Positives = 90/194 (46%), Gaps = 20/194 (10%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQPWPPG-DIKNISTPVRVQGLE-------QVSMIAV 209
            + QV+ G   +V +T EG ++ +G  +     +  +S P  ++ ++        V  ++ 
Sbjct: 428  IHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSC 487

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
            G  H + L+ ++ +++WG  EYG+LG+   +    P RV+    L +V +  G   +  L
Sbjct: 488  GDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLL 547

Query: 390  TKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQVSCGGT 533
            T+ G+V A G  E  +LG         + ++ H VP          L+   I  ++ G T
Sbjct: 548  TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKT 607

Query: 534  HSVVLTSDGRIFSY 575
            H+  +   GR+ ++
Sbjct: 608  HTAAIDERGRLLTF 621



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
 Frame = +3

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 365
           ++  IA G  H  A+     L  +G N+ GQLG+G+ + R     + G L    ++ ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGG 530
           G   + A T +  ++AWG G +GRL     +  H   +          +   +  +SC G
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRG 717

Query: 531 THSVVL 548
            H++++
Sbjct: 718 WHTILI 723



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 33/130 (25%), Positives = 60/130 (46%), Gaps = 14/130 (10%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWG----QPWPPGDIKN---ISTPVRVQGLEQVSMIAV 209
           K+R +A G TH+  + + G + T+G         G+ K    I+      G +QV  ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-------RSQPIRVEGLSNLSLVDIAAG 368
           G    +A + D  ++AWGN   G+L +  T+         S P  + G S   + D++  
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-SLHHVPDLSCR 716

Query: 369 GWHSAALTKE 398
           GWH+  + ++
Sbjct: 717 GWHTILIVEK 726

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 53/186 (28%), Positives = 92/186 (49%), Gaps = 14/186 (7%)
 Frame = +3

Query: 57  RQVAAGGTHSVVLTQEGHVWTW----------GQPWPPGDIKNISTPVRVQGLE--QVSM 200
           RQV AG TH  V+T E  ++TW          GQ    GD  +   P  V+ L+   +  
Sbjct: 372 RQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQ-LGHGDKASYRQPKHVEKLQGKAIHQ 430

Query: 201 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGW 374
           ++ G    + ++ +  L+A+G++ YG +G+         +P+++    +  +  ++ G  
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDN 490

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H   LT+  EVY+WG GE+GRLG  D +  +  P +V +     IV V CG   + +LT 
Sbjct: 491 HVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQ 549

Query: 555 DGRIFS 572
            G++ +
Sbjct: 550 SGKVLA 555



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 47/173 (27%), Positives = 83/173 (47%), Gaps = 9/173 (5%)
 Frame = +3

Query: 84  SVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQ---VSMIAVGAFHNLALSVDRILW 254
           +VV ++   V+ WG           STP ++  ++       +  G  H   ++V++ L+
Sbjct: 340 AVVTSRTSEVYVWGG--------GKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELY 391

Query: 255 AWGNNE-----YGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG 419
            W N +     +GQLG GD     QP  VE L   ++  ++ G   +  +T EG++YA+G
Sbjct: 392 TWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFG 451

Query: 420 RGEHGRLGFGDDKSSHMV-PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
              +G +G        ++ P+Q+       + QVSCG  H VVLT +  ++S+
Sbjct: 452 SDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 93/208 (44%), Gaps = 23/208 (11%)
 Frame = +3

Query: 21   PIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIS--------TPVRV 176
            P+     L   V QV+ G  H VVLT+   V++WG     G+   +         TP +V
Sbjct: 471  PMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWG----CGEYGRLGLDSEEDYYTPQKV 526

Query: 177  QGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQ------------PRSQ 314
               + + ++AV  G      L+    + A G NE+ +LG+                P + 
Sbjct: 527  DVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTT 586

Query: 315  PIRV-EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 491
               + + LS   +  IA G  H+AA+ + G +  +G  + G+LG G+ K    + L    
Sbjct: 587  SFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGP 646

Query: 492  LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            L G+ +++VSCG   ++  T D  IF++
Sbjct: 647  LGGKQVIRVSCGDEFTIAATDDNHIFAW 674



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 44/194 (22%), Positives = 90/194 (46%), Gaps = 20/194 (10%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQPWPPG-DIKNISTPVRVQGLE-------QVSMIAV 209
            + QV+ G   +V +T EG ++ +G  +     +  ++ P  ++ ++        V  ++ 
Sbjct: 428  IHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSC 487

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 389
            G  H + L+ ++ +++WG  EYG+LG+   +    P +V+    L +V +  G   +  L
Sbjct: 488  GDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 547

Query: 390  TKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQVSCGGT 533
            T+ G+V A G  E  +LG         + ++ H VP          L+   I  ++ G T
Sbjct: 548  TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKT 607

Query: 534  HSVVLTSDGRIFSY 575
            H+  +   GR+ ++
Sbjct: 608  HTAAIDERGRLLTF 621



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
 Frame = +3

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 365
           ++  IA G  H  A+     L  +G N+ GQLG+G+ + R     + G L    ++ ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGG 530
           G   + A T +  ++AWG G +GRL     +  H   +          +   +  +SC G
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRG 717

Query: 531 THSVVL 548
            H++++
Sbjct: 718 WHTILI 723



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 33/130 (25%), Positives = 60/130 (46%), Gaps = 14/130 (10%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWG----QPWPPGDIKN---ISTPVRVQGLEQVSMIAV 209
           K+R +A G TH+  + + G + T+G         G+ K    I+      G +QV  ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 210 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-------RSQPIRVEGLSNLSLVDIAAG 368
           G    +A + D  ++AWGN   G+L +  T+         S P  + G S   + D++  
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-SLHHVPDLSCR 716

Query: 369 GWHSAALTKE 398
           GWH+  + ++
Sbjct: 717 GWHTILIVEK 726

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 46/230 (20%)
 Frame = +3

Query: 24   IPQRC-ALKLKVRQVAAGGTHSVVLTQEGHVW-----TWGQPWPPGDIKNIS--TPVRVQ 179
            +P R   L  KV Q+A G  H+VVLT  G V      ++GQ     DIK +   TP+ + 
Sbjct: 871  VPTRVNGLICKVTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLG 930

Query: 180  GLEQVSMIAVGAFHNLALSVDRILWAWGNN------------EYGQLGIGDTQPRSQPI- 320
             L +V  IA   +H++ ++ D  ++ WG N            +     + +T+  S P  
Sbjct: 931  PL-RVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSP 989

Query: 321  -------------------------RVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG 425
                                      V+   + ++V +A G  HSA +T EG +Y WG+G
Sbjct: 990  STNGSTPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKG 1049

Query: 426  EHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
               +LG G +K+  M P QV    G   V VS G  H++  T DG +F++
Sbjct: 1050 LDYQLGHG-NKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAW 1098



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 47/123 (38%), Positives = 72/123 (58%), Gaps = 1/123 (0%)
 Frame = +3

Query: 201  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 380
            IA GA H L LS    L AWG N +GQ G+G +   +   +V+G    ++  IA G +HS
Sbjct: 781  IACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDG-DWPAIEKIACGQFHS 839

Query: 381  AALTKEGEVYAWGRGEHGRLGFGD-DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 557
            A +  +G ++ +G G  G+LG G  + S+ +VP +V  L  + + Q++CG  H+VVLT  
Sbjct: 840  AFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICK-VTQIACGRAHTVVLTDT 898

Query: 558  GRI 566
            GR+
Sbjct: 899  GRV 901



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 59/182 (32%), Positives = 82/182 (45%), Gaps = 9/182 (4%)
 Frame = +3

Query: 57   RQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQG-LEQVSMIAVGAFH 221
            R +A G  H +VL+  G +  WG         G    I+   +V G    +  IA G FH
Sbjct: 779  RAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDGDWPAIEKIACGQFH 838

Query: 222  NLALSVDRILWAWGNNEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALTK 395
            +  +  D  LW +G   +GQLG G     +Q  P RV GL    +  IA G  H+  LT 
Sbjct: 839  SAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIACGRAHTVVLTD 897

Query: 396  EGEVYAWGRGEHGRLGFGDD--KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 569
             G V   G G +G++G  DD  K     PL +  L   DI   +    HS+ +T D R+F
Sbjct: 898  TGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDI---ATHYYHSICITEDNRVF 954

Query: 570  SY 575
             +
Sbjct: 955  EW 956



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 57/218 (26%), Positives = 94/218 (43%), Gaps = 44/218 (20%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWT-----WGQPWPPG-DIKNISTPVRVQGLE-QVSMIAVG 212
            + ++A G  HS  +  +G +WT     WGQ    G +  N   P RV GL  +V+ IA G
Sbjct: 829  IEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICKVTQIACG 888

Query: 213  AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 392
              H + L+    +   G+  YGQ+G+ D   +        L  L + DIA   +HS  +T
Sbjct: 889  RAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICIT 948

Query: 393  KEGEVYAWGRG--------------EHGRLGFGDDKSSHM-----------------VP- 476
            ++  V+ WGR                  +L   +D SS                   +P 
Sbjct: 949  EDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPR 1008

Query: 477  -----LQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
                  +V+     +IV V+CG +HS ++TS+G ++++
Sbjct: 1009 EDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTW 1046



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/177 (25%), Positives = 74/177 (41%), Gaps = 45/177 (25%)
 Frame = +3

Query: 48   LKVRQVAAGGTHSVVLTQEGHVWTWGQ-------------------------PWPPGDIK 152
            L+VR +A    HS+ +T++  V+ WG+                         P  P    
Sbjct: 932  LRVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPST 991

Query: 153  NISTPVRVQ------------GLEQVS--------MIAVGAFHNLALSVDRILWAWGNNE 272
            N STP RV             GL +V          +A G  H+  ++ +  L+ WG   
Sbjct: 992  NGSTP-RVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGL 1050

Query: 273  YGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG 443
              QLG G+   R +P +V   +    V+++ G  H+ A T +G V+AWG+ + G+ G
Sbjct: 1051 DYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCG 1107



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 27/83 (32%), Positives = 47/83 (56%), Gaps = 7/83 (8%)
 Frame = +3

Query: 63   VAAGGTHSVVLTQEGHVWTWGQPWP----PGDIKNISTPVRV---QGLEQVSMIAVGAFH 221
            VA G +HS ++T EG ++TWG+        G+      P +V    G + V+ +++G  H
Sbjct: 1027 VACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVN-VSLGNNH 1085

Query: 222  NLALSVDRILWAWGNNEYGQLGI 290
             +A + D  ++AWG N++GQ G+
Sbjct: 1086 TIASTDDGSVFAWGKNDFGQCGV 1108

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 54/170 (31%), Positives = 87/170 (51%), Gaps = 11/170 (6%)
 Frame = +3

Query: 96  TQEGHVWTWGQPWPPGDIKNIST---------PVRVQGLEQVSMIAVGAFHNLALSVDRI 248
           T+ G V T GQ    GD+  +           P  V  L+ V     G  H + LS    
Sbjct: 32  TEPGLVLTLGQ----GDVGQLGLGESVLERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQ 87

Query: 249 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG--R 422
           ++++G N+ G LG   +   S+ +  +      +V ++AG  H+AALT++G V+ WG  R
Sbjct: 88  VYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFR 147

Query: 423 GEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
             +G +G  +     MVP+QVQL A   +V+V+ G  H V+LT+DG +++
Sbjct: 148 DNNGVIGLLEPMKKSMVPVQVQLDA--PVVKVASGNDHLVMLTNDGDLYT 195



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 53/208 (25%), Positives = 93/208 (44%), Gaps = 24/208 (11%)
 Frame = +3

Query: 24  IPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG--QPWPPGDIKNI-STPVRVQGLEQV 194
           +P +  L   V +VA+G  H V+LT +G ++T G  +    G +  + +     QGL ++
Sbjct: 164 VPVQVQLDAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRL 223

Query: 195 SM-------------------IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQP 317
            +                      GA+   A+S +  ++ +G + Y QLG   T     P
Sbjct: 224 LVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIP 283

Query: 318 IRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 491
             +    N   S V  + G  H+  +  EG+ Y+ GR E+GRLG G+      +P  +  
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343

Query: 492 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           L    +  V+CG +    ++ DGR+F++
Sbjct: 344 L--PVVSSVACGASVGYAVSKDGRVFAW 369



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 48/182 (26%), Positives = 89/182 (48%), Gaps = 11/182 (6%)
 Frame = +3

Query: 45  KLKVRQVAAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQVSMIAV 209
           +++ +    G   +  +++EGHV+ +G     Q   PG   +   P  +   +  +   V
Sbjct: 239 RVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGT-GSCFIPQNLTSFKNSTKSWV 297

Query: 210 G----AFHNLALSVDRILWAWGNNEYGQLGIGD-TQPRSQPIRVEGLSNLSLVDIAAGGW 374
           G      H + +  +   ++ G  EYG+LG+G+  + +S P  +  L  +S   +A G  
Sbjct: 298 GFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVS--SVACGAS 355

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSS-HMVPLQVQLLAGEDIVQVSCGGTHSVVLT 551
              A++K+G V+AWG G + +LG G D+ +   V +  + L    ++ VS GG H+V+L 
Sbjct: 356 VGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLV 415

Query: 552 SD 557
            D
Sbjct: 416 KD 417



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 45/148 (30%), Positives = 77/148 (52%), Gaps = 9/148 (6%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIS------TPVRVQGLE 188
           P    L   V Q  AGG H+V L+Q G V+++G        ++ S       P +V+  E
Sbjct: 60  PALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 119

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGN--NEYGQLGIGDTQPRSQ-PIRVEGLSNLSLVDI 359
           +V  ++ G  H  AL+ D  ++ WG+  +  G +G+ +   +S  P++V+   +  +V +
Sbjct: 120 KVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDAPVVKV 177

Query: 360 AAGGWHSAALTKEGEVYAWGRGEHGRLG 443
           A+G  H   LT +G++Y  G GE G+LG
Sbjct: 178 ASGNDHLVMLTNDGDLYTLGCGEQGQLG 205



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 24/67 (35%), Positives = 38/67 (56%)
 Frame = +3

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L+ 
Sbjct: 27  HRSHNTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLSQ 84

Query: 555 DGRIFSY 575
            G+++S+
Sbjct: 85  SGQVYSF 91

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 17/149 (11%)
 Frame = +3

Query: 180 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI----GDTQPRS---QPIRVEGLS 338
           GL  +  IA G FH  A+     ++AWG N+YGQ  +    G+ +  S   +P  +  LS
Sbjct: 249 GLYNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELS 308

Query: 339 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK----------SSHMVPLQVQ 488
           +  + +IAAG  H+ ALT++G+VYAWGR +   +G   DK           +H     +Q
Sbjct: 309 HKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQ 368

Query: 489 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            L    I  +  G  HS  +T DG ++++
Sbjct: 369 NLFAVKIKTIGVGSHHSFAVTEDGVVYAW 397



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 50/198 (25%), Positives = 86/198 (43%), Gaps = 26/198 (13%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQ--------PWPPGDIKNISTPVRVQG 182
           PQ+  L   ++ +A+G  H   +    +V+ WG             G++++ S  ++   
Sbjct: 245 PQQFGL-YNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTL 303

Query: 183 LEQVSM-----IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV------- 326
           + ++S      IA G  H LAL+ D  ++AWG  +  ++GI   +      ++       
Sbjct: 304 IPELSHKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGS 363

Query: 327 ----EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 494
               + L  + +  I  G  HS A+T++G VYAWG  E    G G        P ++   
Sbjct: 364 FSFLQNLFAVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNT 423

Query: 495 A--GEDIVQVSCGGTHSV 542
           A   EDI+ +  GG  SV
Sbjct: 424 ATKNEDILLIGAGGQFSV 441



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 40/127 (31%), Positives = 52/127 (40%), Gaps = 30/127 (23%)
 Frame = +3

Query: 204 AVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR------------------------- 308
           AVG  H LAL     +W+WG N+   LG    Q +                         
Sbjct: 71  AVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNE 130

Query: 309 --SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGF-GDDKSSHMV 473
             S P  VE L    +V +AA    SAAL   G+VY+WG  R   G LGF  D+      
Sbjct: 131 AESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLGFLRDEIKLQKT 190

Query: 474 PLQVQLL 494
           PL+++ L
Sbjct: 191 PLKIKEL 197



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 34/143 (23%)
 Frame = +3

Query: 249 LWAWGNNEYGQLGIGDT-------QPRSQP-IRVEGLSNLSLVDIAAGGWHSAALTKEGE 404
           ++ WG     +LG+G +       +PR  P +  E L    +VD A GG H+ AL  +  
Sbjct: 26  VFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNR 85

Query: 405 VYAWGRGEHGRLG--------------------------FGDDKSSHMVPLQVQLLAGED 506
           +++WG  +   LG                           GD   +   P  V+ L   +
Sbjct: 86  IWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEAESTPALVENLPEGE 145

Query: 507 IVQVSCGGTHSVVLTSDGRIFSY 575
           IVQ++     S  L S+G ++S+
Sbjct: 146 IVQLAATDNLSAALLSNGDVYSW 168



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
 Frame = +3

Query: 402 EVYAWGRGEHGRLGFGDDKSSHMVP-------LQVQLLAGEDIVQVSCGGTHSVVLTSDG 560
           +V+ WG G    LG G    +  V        L  + L G  IV  + GG H++ L    
Sbjct: 25  DVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKN 84

Query: 561 RIFSY 575
           RI+S+
Sbjct: 85  RIWSW 89

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 57/199 (28%), Positives = 91/199 (45%), Gaps = 22/199 (11%)
 Frame = +3

Query: 45  KLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQ-------GLEQVSMI 203
           K  + Q+A G  H + L +EG V+ WG        + +    R++       GL  V  I
Sbjct: 220 KYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYI 279

Query: 204 AVGAFHNLALSVDRILWAWGNNEYGQLGIG----DTQPRSQPIRVEGLSNLSLVDIAAGG 371
           A G  H  AL+ D  L +WG N++GQ G+     D    ++P R+    N+ +  IAAG 
Sbjct: 280 ASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGE 339

Query: 372 WHSAALTKEGEVYAWGRGEHGRLGFGDDK-----------SSHMVPLQVQLLAGEDIVQV 518
            HS  L+++G++Y+ GR +   +G   D             +  VPL  +L        V
Sbjct: 340 HHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSV 399

Query: 519 SCGGTHSVVLTSDGRIFSY 575
           + G  HSV +  +G  +S+
Sbjct: 400 AAGSHHSVAVAQNGIAYSW 418



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 56/187 (29%), Positives = 90/187 (48%), Gaps = 24/187 (12%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKN---ISTPVRVQGLEQVSM--I 203
           V+ +A+G  H   LT++  + +WG     Q     D+++   ++ P R+   + V +  I
Sbjct: 276 VKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSI 335

Query: 204 AVGAFHNLALSVDRILWAWGNNEYGQLGIG-DTQPRSQPIRVEG----------LSNL-S 347
           A G  H+L LS D  L++ G  +  ++GI  D  P      V G          L+N+  
Sbjct: 336 AAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPK 395

Query: 348 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED--IVQVS 521
              +AAG  HS A+ + G  Y+WG GE   +G G  +    VP +++  A +D  I+ V 
Sbjct: 396 FKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVG 455

Query: 522 CGGTHSV 542
           CGG  SV
Sbjct: 456 CGGQFSV 462



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 54/215 (25%), Positives = 90/215 (41%), Gaps = 40/215 (18%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWG--------------------------QPWPPGDIK 152
           K+   A GG H++ L +E +VW+WG                               GD+ 
Sbjct: 85  KIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLN 144

Query: 153 NI-STPVRVQG------LEQVSMIAVGAFHNL--ALSVDRILWAWGN---NEYGQLGIGD 296
            + STP ++         E   ++ + A  N+  AL  +  ++AWG    NE G LG   
Sbjct: 145 ELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNE-GILGFYQ 203

Query: 297 TQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHM 470
            + + Q  P +V   S  ++V +A G  H   L +EG V+AWG G+  +LG    +   +
Sbjct: 204 DKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRL 263

Query: 471 VPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
             L  +      +  ++ G  H   LT D ++ S+
Sbjct: 264 KTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSW 298



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 35/156 (22%), Positives = 62/156 (39%), Gaps = 36/156 (23%)
 Frame = +3

Query: 216 FHNLALSVDRI-LWAWGNNEYGQLGIGDT-------QPRSQPIRVEGLSNLSLVDIAAGG 371
           + ++ LSV  + ++ WG     +LG+G         +PR  P          ++  A GG
Sbjct: 36  YKHMYLSVQPLDIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPR--DEAKIISFAVGG 93

Query: 372 WHSAALTKEGEVYAWGRGEHGRLG-----------------FGDDKSSHMVPLQ------ 482
            H+ AL +E  V++WG  + G LG                   DD+   +  L+      
Sbjct: 94  MHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKI 153

Query: 483 -----VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
                  L  G  +VQ++     S  L S+G ++++
Sbjct: 154 PRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAW 189



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 15/40 (37%), Positives = 23/40 (57%)
 Frame = +3

Query: 6   RGRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG 125
           + R +P+P +     K + VAAG  HSV + Q G  ++WG
Sbjct: 380 KARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWG 419

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 53/176 (30%), Positives = 88/176 (50%), Gaps = 11/176 (6%)
 Frame = +3

Query: 78  THSVVLTQEGHVWTWGQPWPPGDIKNIST---------PVRVQGLEQVSMIAVGAFHNLA 230
           +H    T+ G V T GQ    GD+  +           P  V  L+ V     G  H + 
Sbjct: 26  SHRSHKTEPGLVLTLGQ----GDVGQLGLGESVLERKKPALVPLLQDVVQAEAGGMHTVC 81

Query: 231 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVY 410
           L+    ++++G N+ G LG   +   S+ +  +      +V ++AG  H+AALT++G V+
Sbjct: 82  LNQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVF 141

Query: 411 AWG--RGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
            WG  R  +G +G  +     MVP+QVQL     +V+V+ G  H V+LT+DG +++
Sbjct: 142 LWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DMPVVKVASGNDHLVMLTTDGDLYT 195



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 54/208 (25%), Positives = 95/208 (45%), Gaps = 24/208 (11%)
 Frame = +3

Query: 24  IPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG--QPWPPGDIKNI-STPVRVQGLEQV 194
           +P +  L + V +VA+G  H V+LT +G ++T G  +    G +  + +     QGLE++
Sbjct: 164 VPVQVQLDMPVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223

Query: 195 SM-------------------IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQP 317
            +                      GA+   A+S +  ++ +G + Y QLG   T     P
Sbjct: 224 LVPKCVLLKSRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIP 283

Query: 318 IRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 491
             +    N   S V  + G  H+  +  EG+ Y+ GR E+GRLG G+      +P  +  
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343

Query: 492 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           L    +  V+CG +    ++ DGR+F++
Sbjct: 344 L--PVVSSVACGASVGYAVSKDGRVFAW 369



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 48/182 (26%), Positives = 89/182 (48%), Gaps = 11/182 (6%)
 Frame = +3

Query: 45  KLKVRQVAAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQVSMIAV 209
           +++ +    G   +  +++EGHV+ +G     Q   PG   +   P  +   +  +   V
Sbjct: 239 RVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLGTPGTA-SCFIPQNLTSFKNSTKSWV 297

Query: 210 G----AFHNLALSVDRILWAWGNNEYGQLGIGD-TQPRSQPIRVEGLSNLSLVDIAAGGW 374
           G      H + +  +   ++ G  EYG+LG+G+  + +S P  +  L  +S   +A G  
Sbjct: 298 GFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVS--SVACGAS 355

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSS-HMVPLQVQLLAGEDIVQVSCGGTHSVVLT 551
              A++K+G V+AWG G + +LG G D+ +   V +  + L    ++ VS GG H+V+L 
Sbjct: 356 VGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLV 415

Query: 552 SD 557
            D
Sbjct: 416 KD 417



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 45/148 (30%), Positives = 77/148 (52%), Gaps = 9/148 (6%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIS------TPVRVQGLE 188
           P    L   V Q  AGG H+V L Q G V+++G        ++ S       P +V+  E
Sbjct: 60  PALVPLLQDVVQAEAGGMHTVCLNQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 119

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGN--NEYGQLGIGDTQPRSQ-PIRVEGLSNLSLVDI 359
           +V  ++ G  H  AL+ D  ++ WG+  +  G +G+ +   +S  P++V+   ++ +V +
Sbjct: 120 KVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDMPVVKV 177

Query: 360 AAGGWHSAALTKEGEVYAWGRGEHGRLG 443
           A+G  H   LT +G++Y  G GE G+LG
Sbjct: 178 ASGNDHLVMLTTDGDLYTLGCGEQGQLG 205



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 56/208 (26%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
 Frame = +3

Query: 24  IPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDI-------KNISTPVRVQG 182
           +P +  L+ KV QV+AG +H+  LT++G V+ WG       +       K    PV+VQ 
Sbjct: 111 VPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170

Query: 183 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--------IGDTQ-------PRSQP 317
              V  +A G  H + L+ D  L+  G  E GQLG         G  Q       P+   
Sbjct: 171 DMPVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVL 230

Query: 318 IRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 494
           ++  G    +   D   G + + A+++EG VY +G   + +LG     +S  +P  +   
Sbjct: 231 LKSRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLG-TPGTASCFIPQNLTSF 289

Query: 495 --AGEDIVQVSCGGTHSVVLTSDGRIFS 572
             + +  V  S G  H++ + S+G+ +S
Sbjct: 290 KNSTKSWVGFSGGQHHTICMDSEGKAYS 317



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 7/120 (5%)
 Frame = +3

Query: 66  AAGGTHSVVLTQEGHVWT-----WGQPWPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLA 230
           + G  H++ +  EG  ++     +G+       +  S P  +  L  VS +A GA    A
Sbjct: 300 SGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSSVACGASVGYA 359

Query: 231 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLSLVDIAAGGWHSAALTKEGE 404
           +S D  ++AWG     QLG G  +    P+ + G  L N  ++ +++GG H+  L K+ E
Sbjct: 360 VSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDKE 419



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 24/67 (35%), Positives = 37/67 (55%)
 Frame = +3

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L  
Sbjct: 27  HRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLNQ 84

Query: 555 DGRIFSY 575
            G+++S+
Sbjct: 85  SGQVYSF 91

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 55/208 (26%), Positives = 96/208 (46%), Gaps = 24/208 (11%)
 Frame = +3

Query: 24  IPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG--QPWPPGDIKNI-STPVRVQGLEQV 194
           +P +  L + V +VA+G  H V+LT +G ++T G  +    G +  + +     QGLE++
Sbjct: 164 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 223

Query: 195 SM-------------------IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQP 317
            +                      GA+   A+S +  ++ +G + Y QLG   T+    P
Sbjct: 224 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 283

Query: 318 IRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 491
             +    N   S V  + G  H+  +  EG+ Y+ GR E+GRLG G+      +P  +  
Sbjct: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343

Query: 492 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           L    +  V+CG +    +T DGR+F++
Sbjct: 344 LPA--VSSVACGASVGYAVTKDGRVFAW 369



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 11/176 (6%)
 Frame = +3

Query: 78  THSVVLTQEGHVWTWGQPWPPGDIKNIST---------PVRVQGLEQVSMIAVGAFHNLA 230
           +H    T+ G V T GQ    GD+  +           P  V   E V     G  H + 
Sbjct: 26  SHRSHSTEPGLVLTLGQ----GDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVC 81

Query: 231 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVY 410
           LS    ++++G N+ G LG   +   S+ +  +      +V ++AG  H+AALT +G V+
Sbjct: 82  LSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVF 141

Query: 411 AWG--RGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
            WG  R  +G +G  +     MVP+QVQL     +V+V+ G  H V+LT+DG +++
Sbjct: 142 LWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYT 195



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 49/181 (27%), Positives = 88/181 (48%), Gaps = 11/181 (6%)
 Frame = +3

Query: 48  LKVRQVAAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTPVRVQGLEQVSMIAVG 212
           ++ +    G   +  ++ EGHV+ +G     Q   PG  ++   P  +   +  +   VG
Sbjct: 240 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT-ESCFIPQNLTSFKNSTKSWVG 298

Query: 213 ----AFHNLALSVDRILWAWGNNEYGQLGIGD-TQPRSQPIRVEGLSNLSLVDIAAGGWH 377
                 H + +  +   ++ G  EYG+LG+G+  + +S P  +  L  +S   +A G   
Sbjct: 299 FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASV 356

Query: 378 SAALTKEGEVYAWGRGEHGRLGFGDDKSS-HMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
             A+TK+G V+AWG G + +LG G D+ +   V +  + L    ++ VS GG H+V+L  
Sbjct: 357 GYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK 416

Query: 555 D 557
           D
Sbjct: 417 D 417



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 57/208 (27%), Positives = 93/208 (44%), Gaps = 25/208 (12%)
 Frame = +3

Query: 24  IPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDI-------KNISTPVRVQG 182
           +P +  L+ KV QV+AG +H+  LT +G V+ WG       +       K    PV+VQ 
Sbjct: 111 VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170

Query: 183 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--------IGDTQ-------PRSQP 317
              V  +A G  H + L+ D  L+  G  E GQLG         G  Q       P+   
Sbjct: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230

Query: 318 IRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 494
           ++  G   ++   D   G + + A++ EG VY +G   + +LG    +S   +P  +   
Sbjct: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESC-FIPQNLTSF 289

Query: 495 --AGEDIVQVSCGGTHSVVLTSDGRIFS 572
             + +  V  S G  H+V + S+G+ +S
Sbjct: 290 KNSTKSWVGFSGGQHHTVCMDSEGKAYS 317



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 43/148 (29%), Positives = 79/148 (53%), Gaps = 9/148 (6%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIS------TPVRVQGLE 188
           P   ++   V Q  AGG H+V L++ G V+++G        ++ S       P +V+  E
Sbjct: 60  PALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE 119

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGN--NEYGQLGIGDTQPRSQ-PIRVEGLSNLSLVDI 359
           +V  ++ G  H  AL+ D  ++ WG+  +  G +G+ +   +S  P++V+   ++ +V +
Sbjct: 120 KVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVPVVKV 177

Query: 360 AAGGWHSAALTKEGEVYAWGRGEHGRLG 443
           A+G  H   LT +G++Y  G GE G+LG
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLG 205



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 23/67 (34%), Positives = 38/67 (56%)
 Frame = +3

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H +  T+ G V   G+G+ G+LG G++      P  V +   ED+VQ   GG H+V L+ 
Sbjct: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84

Query: 555 DGRIFSY 575
            G+++S+
Sbjct: 85  SGQVYSF 91

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 11/195 (5%)
 Frame = +3

Query: 18  IPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG--------QPWPPGDIKNISTPV- 170
           +P+P     + KV QV+ G  HS+VLT    V++ G        +     ++ + S  V 
Sbjct: 161 VPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVH 220

Query: 171 RVQGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNL 344
           R+Q  + QV  +  G  H+L L+    +++ G    GQ G+G     S P ++ G L+ +
Sbjct: 221 RMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGV 280

Query: 345 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 524
           ++V +A  G    AL+ +G V+ WG  E+ +L    D +   VP  +       + QV+C
Sbjct: 281 TVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVAC 340

Query: 525 GGTHSVVLTSDGRIF 569
           GGT   VL ++G +F
Sbjct: 341 GGTGCAVLNAEGHVF 355



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 39/133 (29%), Positives = 68/133 (51%), Gaps = 4/133 (3%)
 Frame = +3

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--IGDTQPRSQPIRVEGLSNLS--LVD 356
           +V  ++ G  H+L L+    +++ GNN +GQ G  + + +  S+  +V  + +    +V 
Sbjct: 172 KVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQ 231

Query: 357 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 536
           +  G  HS  LT +GEVY+ G G  G+ G G    +         LAG  +VQV+  G  
Sbjct: 232 VVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDC 291

Query: 537 SVVLTSDGRIFSY 575
            + L++DG +F +
Sbjct: 292 CLALSADGGVFGW 304



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 48/127 (37%), Positives = 57/127 (44%), Gaps = 12/127 (9%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIST------PVRVQGLE------QV 194
           KV+QVA GGT   VL  EGHV+ WG        K + T      P  + GL       QV
Sbjct: 334 KVKQVACGGTGCAVLNAEGHVFVWGYGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQV 393

Query: 195 SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW 374
           S I  G  H  AL+    L+ WG N  G LGIG  + +  P RV        VD+A G  
Sbjct: 394 SQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPG--EPVDVACGVD 451

Query: 375 HSAALTK 395
           H   L K
Sbjct: 452 HMVTLAK 458



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 55/181 (30%), Positives = 82/181 (45%), Gaps = 16/181 (8%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWG-----QPWPPGDIKNISTP--VRVQGLEQVSMIAVG 212
           V QVA  G   + L+ +G V+ WG     Q     D   ++ P  +   G+ +V  +A G
Sbjct: 282 VVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACG 341

Query: 213 AFHNLALSVDRILWAWGNNEYGQLGIGDTQ-----PRSQPIRVEGLSNLS----LVDIAA 365
                 L+ +  ++ WG   YG LG G        P   P  + GL+  +    +  I  
Sbjct: 342 GTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRC 398

Query: 366 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 545
           G  H AALT +GE++ WG+   G LG G  +  +  P +V  + GE  V V+CG  H V 
Sbjct: 399 GLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRV-TMPGEP-VDVACGVDHMVT 455

Query: 546 L 548
           L
Sbjct: 456 L 456



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 20/156 (12%)
 Frame = +3

Query: 165 PVRVQGLEQVSMIAVGAFHNLALSVDRIL---WAWGNNEYGQLGIGDT------------ 299
           P R++   ++S  A G    L  S  + +   W  G N+  QLG   +            
Sbjct: 97  PYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 156

Query: 300 QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG---FGDD--KSS 464
           +P   P+ ++      ++ ++ G  HS  LT    V++ G   HG+ G     D+    S
Sbjct: 157 EPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSES 216

Query: 465 HMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           H V  ++Q   G+ +VQV CG  HS+ LT  G ++S
Sbjct: 217 HKVH-RMQDFDGQ-VVQVVCGQDHSLFLTDKGEVYS 250



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 37/144 (25%), Positives = 58/144 (40%), Gaps = 29/144 (20%)
 Frame = +3

Query: 228 ALSVDRILWAWGNNEYGQLGI-------------GDTQPRSQ----PIRVEGLSNLSLVD 356
           A   DR+ + WG +  G LG+                +PR +    P R+E    +S   
Sbjct: 52  AARADRV-FVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDHKISSAA 110

Query: 357 IAAGGWHSAALTKE-GEVYAWGRGEHGRLGFGDDKSSHM-----------VPLQVQLLAG 500
              G    ++ TK+  +V+  G  +  +LGF   +               VPL +     
Sbjct: 111 CGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQE 170

Query: 501 EDIVQVSCGGTHSVVLTSDGRIFS 572
             ++QVSCG  HS+VLT    +FS
Sbjct: 171 TKVLQVSCGRAHSLVLTDREGVFS 194

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 53/195 (27%), Positives = 94/195 (48%), Gaps = 11/195 (5%)
 Frame = +3

Query: 18  IPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG--------QPWPPGDIKNISTPV- 170
           + +P     + +V QV+ G  HS+VLT    V++ G        +     +I + S  V 
Sbjct: 164 VSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223

Query: 171 RVQGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNL 344
           R+Q  + QV  +A G  H+L L+    +++ G    GQ G+G     S P ++ G L+ +
Sbjct: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283

Query: 345 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 524
           +++ +A  G    A++ +G ++ WG  E+ +L    D +   VP  +       + Q +C
Sbjct: 284 NVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAAC 343

Query: 525 GGTHSVVLTSDGRIF 569
           GGT   VL  +G +F
Sbjct: 344 GGTGCAVLNGEGHVF 358



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 42/144 (29%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
 Frame = +3

Query: 156 ISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--IGDTQPRSQPIRVE 329
           +S P+      +V  ++ G  H+L L+    +++ GNN YGQ G  + + +  S+  RV 
Sbjct: 164 VSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223

Query: 330 GLSNLS--LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGE 503
            + +    +V +A G  HS  LT +GEVY+ G G  G+ G G    +         LAG 
Sbjct: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283

Query: 504 DIVQVSCGGTHSVVLTSDGRIFSY 575
           +++QV+  G   + +++DG +F +
Sbjct: 284 NVIQVATYGDCCLAVSADGGLFGW 307



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 65/232 (28%), Positives = 95/232 (40%), Gaps = 66/232 (28%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWT--WGQPWPPG--DIKNISTPVRVQG-LEQVSMIAVGA 215
           +V QVA G  HS+ LT +G V++  WG     G       S+P ++ G L  V++I V  
Sbjct: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290

Query: 216 FHN--LALSVDRILWAWGNNEYGQL------------------GIGDTQ----------- 302
           + +  LA+S D  L+ WGN+EY QL                  G+G  +           
Sbjct: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350

Query: 303 --------------------------PRSQPIRVEGLSN----LSLVDIAAGGWHSAALT 392
                                     P   P  + GL+     + +  I  G  H AALT
Sbjct: 351 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410

Query: 393 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 548
            +GE++ WG+   G LG G  +  +  P +V  + GE  V V+CG  H V L
Sbjct: 411 NKGELFVWGKNIRGCLGIGRLEDQYF-PWRV-TMPGEP-VDVACGVDHMVTL 459



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 47/127 (37%), Positives = 57/127 (44%), Gaps = 12/127 (9%)
 Frame = +3

Query: 51  KVRQVAAGGTHSVVLTQEGHVWTWGQ---PWPPGDIKNI---STPVRVQGLE------QV 194
           KVRQ A GGT   VL  EGHV+ WG       P  +++      P  + GL       QV
Sbjct: 337 KVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQV 396

Query: 195 SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW 374
           S I  G  H  AL+    L+ WG N  G LGIG  + +  P RV        VD+A G  
Sbjct: 397 SRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPG--EPVDVACGVD 454

Query: 375 HSAALTK 395
           H   L K
Sbjct: 455 HMVTLAK 461



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
 Frame = +3

Query: 165 PVRVQGLEQVSMIAVGAFHNLALS----VDRILWAWGNNEYGQLGIGDT----------- 299
           P R++  +++S  A G    L  S    V ++ W  G N+  QLG   +           
Sbjct: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKV-WGMGLNKDSQLGFHRSRKDKTRGYEYV 158

Query: 300 -QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKS----- 461
            +P    + ++      ++ ++ G  HS  LT    V++ G   +G+ G    ++     
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218

Query: 462 SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 572
           SH V  ++Q   G+ +VQV+CG  HS+ LT  G ++S
Sbjct: 219 SHRVH-RMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 41/107 (38%), Positives = 59/107 (55%), Gaps = 2/107 (1%)
 Frame = +3

Query: 261 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 437
           G  + GQLG+G D   R +P  V    ++  V  AAGG H+  L   G +Y +G  + G 
Sbjct: 47  GQGDVGQLGLGEDIMERKKPALVTLTEDI--VQAAAGGMHTVCLGASGSIYTFGCNDEGA 104

Query: 438 LGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           LG    ++ S M P +V+L   E +VQVS G +H+  LT DGR+F +
Sbjct: 105 LGRDTSEEGSEMQPGKVEL--AEKVVQVSAGDSHTAALTEDGRVFVF 149



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 23/207 (11%)
 Frame = +3

Query: 24  IPQRCALKLKVRQVAAGGTHSVVLTQEGHVWT--WGQPWPPGDI-KNISTPVRVQGLEQV 194
           +P +  +   V ++A+G  H V+LT +G ++T   G+    G + +  +     +GLE++
Sbjct: 170 VPVQVQINTPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERL 229

Query: 195 SM------------------IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPI 320
            +                  +  GA+   A+S +  ++ +G + Y QLG  +TQ    P 
Sbjct: 230 LVPQCIHLKAKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQ 289

Query: 321 RVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 494
            +    N   S +  + G  H+  +  EG+ Y+ GR E+GRLG G++      P  +  L
Sbjct: 290 NLTSFKNSTKSWIGFSGGQHHTVCVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDL 349

Query: 495 AGEDIVQVSCGGTHSVVLTSDGRIFSY 575
               I  V+ G + S  +++DG +F++
Sbjct: 350 --PKINSVASGASVSYAVSTDGCVFAW 374



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 54/206 (26%), Positives = 95/206 (46%), Gaps = 24/206 (11%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDI-------KNISTPVRVQGL 185
           P +  L  KV QV+AG +H+  LT++G V+ +G       +       K    PV+VQ  
Sbjct: 118 PGKVELAEKVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGLLEPMKKSMVPVQVQIN 177

Query: 186 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ---------------PRSQPI 320
             V  IA G  H + L+VD  L+  G  E GQLG    +               P+   +
Sbjct: 178 TPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHL 237

Query: 321 RVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL-- 494
           + +G   +   D+  G + + A+++EG VY +G   + +LG  + ++ +  P  +     
Sbjct: 238 KAKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACY-APQNLTSFKN 296

Query: 495 AGEDIVQVSCGGTHSVVLTSDGRIFS 572
           + +  +  S G  H+V + S+G+ +S
Sbjct: 297 STKSWIGFSGGQHHTVCVDSEGKAYS 322



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 54/206 (26%), Positives = 99/206 (48%), Gaps = 23/206 (11%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIS------TPVRVQGLE 188
           P    L   + Q AAGG H+V L   G ++T+G        ++ S       P +V+  E
Sbjct: 66  PALVTLTEDIVQAAAGGMHTVCLGASGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAE 125

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGN--NEYGQLGIGDTQPRSQ-PIRVEGLSNLSLVDI 359
           +V  ++ G  H  AL+ D  ++ +G+  +  G +G+ +   +S  P++V+   N  ++ I
Sbjct: 126 KVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGLLEPMKKSMVPVQVQ--INTPVIKI 183

Query: 360 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSH----------MVPLQVQLLA-GED 506
           A+G  H   LT +G++Y  G GE G+LG   ++ ++          +VP  + L A G  
Sbjct: 184 ASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGSG 243

Query: 507 IV---QVSCGGTHSVVLTSDGRIFSY 575
            V    V CG   +  ++ +G ++ +
Sbjct: 244 RVHFQDVFCGAYFTFAVSQEGHVYGF 269



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%)
 Frame = +3

Query: 375 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 554
           H +  T  G+V   G+G+ G+LG G+D      P  V L   EDIVQ + GG H+V L +
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLT--EDIVQAAAGGMHTVCLGA 90

Query: 555 DGRIFSY 575
            G I+++
Sbjct: 91  SGSIYTF 97



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 29/118 (24%), Positives = 60/118 (50%), Gaps = 7/118 (5%)
 Frame = +3

Query: 66  AAGGTHSVVLTQEGHVWT-----WGQPWPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLA 230
           + G  H+V +  EG  ++     +G+     + +  S P  +  L +++ +A GA  + A
Sbjct: 305 SGGQHHTVCVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDLPKINSVASGASVSYA 364

Query: 231 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLSLVDIAAGGWHSAALTKE 398
           +S D  ++AWG     QLG G+ +    P ++ G  L +  ++ +++GG H+  L ++
Sbjct: 365 VSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQHTVLLVRK 422

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 34/84 (40%), Positives = 52/84 (61%)
 Frame = +3

Query: 192  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 371
            V  +A G  H + L++   ++ +G+N+YGQLG GD QP S P+RV+    +S   +AAG 
Sbjct: 968  VVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAIS--QVAAGS 1025

Query: 372  WHSAALTKEGEVYAWGRGEHGRLG 443
             H+  LT +G VY +G  + G+LG
Sbjct: 1026 NHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 4/82 (4%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVSMIAVGAFH 221
            V QVA G  H+VVLT  G V+T+G         GD++ +S PVRVQ    +S +A G+ H
Sbjct: 968  VVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAISQVAAGSNH 1027

Query: 222  NLALSVDRILWAWGNNEYGQLG 287
             + L+   +++ +GN + GQLG
Sbjct: 1028 TVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 34/94 (36%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
 Frame = +3

Query: 303  PRSQPIRVEGL---SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 473
            PR  P+  + L   S+  +V +A G  H+  LT  GEVY +G  ++G+LG GD +     
Sbjct: 950  PRVAPLAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSG- 1008

Query: 474  PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            P++VQ+     I QV+ G  H+V+LTS G ++++
Sbjct: 1009 PVRVQVPGA--ISQVAAGSNHTVLLTSKGMVYTF 1040



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 15/33 (45%), Positives = 22/33 (66%)
 Frame = +3

Query: 27   PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWG 125
            P R  +   + QVAAG  H+V+LT +G V+T+G
Sbjct: 1009 PVRVQVPGAISQVAAGSNHTVLLTSKGMVYTFG 1041

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 9/142 (6%)
 Frame = +3

Query: 174 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 353
           V G+     I+ G  HNL L+    ++++G N+ G LG   ++  S+       S   L+
Sbjct: 70  VAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSE-------SKPDLI 122

Query: 354 D-------IAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDDKSSHMVPLQVQLLAGED 506
           D       I+AG  HSA L ++G V+AWG  R  HG +G   D +       + L+ G  
Sbjct: 123 DLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKR---TPIDLMEGTV 179

Query: 507 IVQVSCGGTHSVVLTSDGRIFS 572
              ++ G  H V+LT+ G++F+
Sbjct: 180 CCSIASGADHLVILTTAGKVFT 201



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 6/111 (5%)
 Frame = +3

Query: 261 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 437
           GN + GQLG+G D   R +   V G+ +   VDI+AGG H+  LTK G++Y++G  + G 
Sbjct: 48  GNGDVGQLGLGEDILERKRLSPVAGIPDA--VDISAGGMHNLVLTKSGDIYSFGCNDEGA 105

Query: 438 LG-----FGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
           LG      G +    ++ L  + L       +S G +HS  L  DGR+F++
Sbjct: 106 LGRDTSEDGSESKPDLIDLPGKALC------ISAGDSHSACLLEDGRVFAW 150



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 59/193 (30%), Positives = 89/193 (46%), Gaps = 22/193 (11%)
 Frame = +3

Query: 63  VAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNIST-PVRVQG-------LEQVSMIAVGAF 218
           +A+G  H V+LT  G V+T G     G +  +S   +  +G       L    +I   A 
Sbjct: 183 IASGADHLVILTTAGKVFTVGCA-EQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAK 241

Query: 219 HNLAL-----------SVDRILWAWGNNEYGQLGIGDTQPRS---QPIRVEGLSNLSLVD 356
              A+           S  +++WA G N + QL   +T+ +     PI+ E L ++    
Sbjct: 242 PFEAIWATNYCTFMRESQTQVIWATGLNNFKQLA-HETKGKEFALTPIKTE-LKDIR--H 297

Query: 357 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 536
           IA G  H+  LT + +    GR E+GRLG GD K     P  V+ L  E IV V CG   
Sbjct: 298 IAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT-EKIVSVGCGEVC 356

Query: 537 SVVLTSDGRIFSY 575
           S  +T DG+++S+
Sbjct: 357 SYAVTIDGKLYSW 369



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 39/139 (28%), Positives = 71/139 (51%), Gaps = 9/139 (6%)
 Frame = +3

Query: 6   RGRDIPI-PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQP----WPPGDIKNI-STP 167
           +G++  + P +  LK  +R +A G  H+V+LT +      G+P       GD+K++   P
Sbjct: 279 KGKEFALTPIKTELK-DIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKP 337

Query: 168 VRVQGL-EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV--EGLS 338
             V+ L E++  +  G   + A+++D  L++WG+    QLG+GD     +PI V  +   
Sbjct: 338 TIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQ 397

Query: 339 NLSLVDIAAGGWHSAALTK 395
              ++  + GG H+  L K
Sbjct: 398 GKHMLLASGGGQHAIFLVK 416



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 37/141 (26%), Positives = 68/141 (48%), Gaps = 8/141 (5%)
 Frame = +3

Query: 63  VAAGGTHSVVLTQEGHVWTWG------QPWPPGDIKNISTPVRVQGLEQVSMIAVGAFHN 224
           ++AGG H++VLT+ G ++++G            +  + S P  +    +   I+ G  H+
Sbjct: 79  ISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHS 138

Query: 225 LALSVDRILWAWGN--NEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKE 398
             L  D  ++AWG+  + +G +G+     +  PI +  +       IA+G  H   LT  
Sbjct: 139 ACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDL--MEGTVCCSIASGADHLVILTTA 196

Query: 399 GEVYAWGRGEHGRLGFGDDKS 461
           G+V+  G  E G+LG   ++S
Sbjct: 197 GKVFTVGCAEQGQLGRLSERS 217



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
 Frame = +3

Query: 399 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAG-EDIVQVSCGGTHSVVLTSDGRIFSY 575
           G V   G G+ G+LG G+D        ++  +AG  D V +S GG H++VLT  G I+S+
Sbjct: 42  GNVLVCGNGDVGQLGLGEDILERK---RLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSF 98



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 50/200 (25%), Positives = 84/200 (42%), Gaps = 23/200 (11%)
 Frame = +3

Query: 27  PQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQ-PWPPGDI-----KNISTPVRVQGLE 188
           P    L  K   ++AG +HS  L ++G V+ WG      G++      N  TP+ +    
Sbjct: 119 PDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGT 178

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-------LSNLS 347
               IA GA H + L+    ++  G  E GQLG    +   + I  EG       L    
Sbjct: 179 VCCSIASGADHLVILTTAGKVFTVGCAEQGQLG----RLSERSISGEGRRGKRDLLRPTQ 234

Query: 348 LVDIAAGGWHSAALT------KEGE---VYAWGRGEHGRLGF-GDDKSSHMVPLQVQLLA 497
           L+   A  + +   T      +E +   ++A G     +L      K   + P++ +L  
Sbjct: 235 LIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTEL-- 292

Query: 498 GEDIVQVSCGGTHSVVLTSD 557
            +DI  ++ G  H+V+LT+D
Sbjct: 293 -KDIRHIAGGQHHTVILTTD 311

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 32/78 (41%), Positives = 46/78 (58%)
 Frame = +3

Query: 342  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 521
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 522  CGGTHSVVLTSDGRIFSY 575
             G  H+ VL  DG++F++
Sbjct: 960  AGSNHTAVLLMDGQVFTF 977



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 31/104 (29%), Positives = 52/104 (50%)
 Frame = +3

Query: 132  WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
            +PPG ++       VQ       ++ G  H++ L  +  ++ +G  ++GQLG GD   R 
Sbjct: 891  YPPGSVRFDCELRAVQ-------VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG 943

Query: 312  QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG 443
             P  V+ L   S   + AG  H+A L  +G+V+ +G    G+LG
Sbjct: 944  CPTLVQALPGPS-TQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 5/86 (5%)
 Frame = +3

Query: 45   KLKVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVS-MIAV 209
            +L+  QV+ G  HSVVL + G V+T+G         GD+ +   P  VQ L   S  +  
Sbjct: 901  ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLG 287
            G+ H   L +D  ++ +G+   GQLG
Sbjct: 961  GSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 36.2 bits (82), Expect = 0.069
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 4/123 (3%)
 Frame = +3

Query: 219 HNLALSVDRILWAWGNNEYGQLGIGDTQPRS----QPIRVEGLSNLSLVDIAAGGWHSAA 386
           H L ++ D  ++  G+   G+ G      R     +P ++  +    +V  A     S+ 
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 387 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 566
           ++K+GE+Y +G+          D SS +  L+     G  + QV+ G  H+ VL  +G +
Sbjct: 615 ISKDGELYMFGKD-----AIYSDSSSLVTDLK-----GHFVTQVAMGKAHTCVLMKNGEV 664

Query: 567 FSY 575
           +++
Sbjct: 665 WTF 667



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 13/24 (54%), Positives = 16/24 (66%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWG 125
           V QVA G  H+ VL + G VWT+G
Sbjct: 645 VTQVAMGKAHTCVLMKNGEVWTFG 668

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 30/84 (35%), Positives = 52/84 (61%)
 Frame = +3

Query: 189  QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 368
            +VS ++ G FH + L+ DR ++ +G+N +GQLG+GDT  ++ P +V   S+  +V +AAG
Sbjct: 768  KVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAG 827

Query: 369  GWHSAALTKEGEVYAWGRGEHGRL 440
              H+     +G V+ +G    G+L
Sbjct: 828  SNHTILRANDGSVFTFGAFGKGQL 851



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 28/89 (31%), Positives = 51/89 (57%)
 Frame = +3

Query: 309  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 488
            S+ I  +G  ++ +  ++ G +H+  L  +  V+ +G   HG+LG GD  S +  P QV 
Sbjct: 756  SRVILSQGPHDVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKN-TPQQVI 814

Query: 489  LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            L +   IVQV+ G  H+++  +DG +F++
Sbjct: 815  LPSDTVIVQVAAGSNHTILRANDGSVFTF 843



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 45/186 (24%), Positives = 76/186 (40%), Gaps = 12/186 (6%)
 Frame = +3

Query: 54   VRQVAAGGTHSVVLTQEGHVWTWG--QPWPPGDIKNIST--PVRVQGLEQVSMIAVGAFH 221
            +  +A G +H V +T+ GH++TWG       G +++ ST    R  G ++  +  +G  H
Sbjct: 615  ISSLALGKSHGVAVTRNGHLFTWGLNNMNQCGRVESTSTTSSPRHSGRQEYQICPIGE-H 673

Query: 222  NLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKE- 398
                    +    G      +  G   PR +         +    +         L +  
Sbjct: 674  TWLTDTPSVCAQCGLCSARGVACGRV-PRPK-------GTMCHCGVGESTCLRCGLCRPC 725

Query: 399  GEV---YAWGRGEHGRL-GFGDDKSSHMVPLQVQLLAGEDIVQ---VSCGGTHSVVLTSD 557
            GEV      GR +H +       + S + P +V L  G   V+   VSCG  H+V+L SD
Sbjct: 726  GEVTEPAQPGRAQHVQFSSTAAPQRSTLHPSRVILSQGPHDVKVSSVSCGNFHTVLLASD 785

Query: 558  GRIFSY 575
             R+F++
Sbjct: 786  RRVFTF 791

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 31/78 (39%), Positives = 45/78 (57%)
 Frame = +3

Query: 342  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 521
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 522  CGGTHSVVLTSDGRIFSY 575
                H+ VL  DG++F++
Sbjct: 960  ACSNHTAVLLMDGQVFTF 977



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 30/104 (28%), Positives = 51/104 (49%)
 Frame = +3

Query: 132  WPPGDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 311
            +PPG ++       VQ       ++ G  H++ L  +  ++ +G  ++GQLG GD   R 
Sbjct: 891  YPPGSVRFDCELRAVQ-------VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG 943

Query: 312  QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG 443
             P  V+ L   S   + A   H+A L  +G+V+ +G    G+LG
Sbjct: 944  CPTLVQALPGPS-TQVTACSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 5/86 (5%)
 Frame = +3

Query: 45   KLKVRQVAAGGTHSVVLTQEGHVWTWGQ----PWPPGDIKNISTPVRVQGLEQVS-MIAV 209
            +L+  QV+ G  HSVVL + G V+T+G         GD+ +   P  VQ L   S  +  
Sbjct: 901  ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960

Query: 210  GAFHNLALSVDRILWAWGNNEYGQLG 287
             + H   L +D  ++ +G+   GQLG
Sbjct: 961  CSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 29/123 (23%), Positives = 55/123 (44%), Gaps = 4/123 (3%)
 Frame = +3

Query: 219 HNLALSVDRILWAWGNNEYGQLGIGDTQPRS----QPIRVEGLSNLSLVDIAAGGWHSAA 386
           H L ++ D  ++  G+   G+ G      R     +P ++  +    +V  A     S+ 
Sbjct: 555 HALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 387 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 566
           ++K+GE+Y +G+          D SS      V  L G  + QV+ G  H+ VL  +G +
Sbjct: 615 ISKDGELYMFGKD-----AIYSDSSS-----LVSDLKGHFVTQVAMGKAHTCVLMKNGEV 664

Query: 567 FSY 575
           +++
Sbjct: 665 WTF 667



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 13/24 (54%), Positives = 16/24 (66%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWG 125
           V QVA G  H+ VL + G VWT+G
Sbjct: 645 VTQVAMGKAHTCVLMKNGEVWTFG 668

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 55/209 (26%), Positives = 89/209 (42%), Gaps = 33/209 (15%)
 Frame = +3

Query: 48  LKVRQVAAGGTHSVVLTQEGHVWTWG-------------QPWPPGDIKNISTPVRVQGLE 188
           LK  Q  AGG HS VLT EG V+  G             +     +   +     ++   
Sbjct: 185 LKPLQAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEKEG 244

Query: 189 QVSMIAVGAFHNLALSVDRILWAWGN--NEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVD 356
           ++ M+A GA    AL+    + AWGN  N  G + +     + Q  P+ +   +   +V 
Sbjct: 245 KIVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVK 304

Query: 357 IAAGGWHSAALTKEGEVYAWGRGEHGRLG------------FGDDKSSH-MVPLQVQLLA 497
           IAAG  H   L ++G +  +G GE G+LG              D+   H +VPL+ +   
Sbjct: 305 IAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKG 364

Query: 498 G-EDIV--QVSCGGTHSVVLTSDGRIFSY 575
              D+V   V   G  ++V   DG+ +++
Sbjct: 365 KFFDVVAKNVFASGFWTIVHGEDGKYYAF 393



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 11/146 (7%)
 Frame = +3

Query: 171 RVQGLEQVSMIAVGAFHNL---ALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPI-RVEGL 335
           +  G +Q  ++A    ++L   ++  DR+L        G  G   T+ PR   I   EGL
Sbjct: 126 KTPGRKQAKLVAPLLTYDLFAPSIIGDRVLSCGEGEALGHPGRTTTKKPRKVDIFEEEGL 185

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGF------GDDKSSHMVPLQVQLLA 497
             L  V   AGG HSA LT EGEVY  G  E G +        G       V  +  +  
Sbjct: 186 KPLQAV---AGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEK 242

Query: 498 GEDIVQVSCGGTHSVVLTSDGRIFSY 575
              IV ++ G + +  LT  G + ++
Sbjct: 243 EGKIVMLAAGASFTAALTDQGSVIAW 268



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 11/134 (8%)
 Frame = +3

Query: 180 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG------DTQPRSQPIRVEGLSN 341
           G E+  +   G  H + L  D  ++A G N    LG+G      D Q        E   +
Sbjct: 432 GAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFD 491

Query: 342 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQL----LAGED 506
             +V ++A    S A +++G  YAWG    G+LG G  D+   MV    ++    L G  
Sbjct: 492 SKIVGVSAKLATSIAWSEDGTAYAWGFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGYS 551

Query: 507 IVQVSCGGTHSVVL 548
           I+  S    H++++
Sbjct: 552 IIGASISDQHTLII 565



 Score = 36.6 bits (83), Expect = 0.053
 Identities = 48/223 (21%), Positives = 84/223 (37%), Gaps = 46/223 (20%)
 Frame = +3

Query: 45  KLKVRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQVSM-------- 200
           K K+ ++AAG  H V+L ++G + T+G     G++  +    R + +    M        
Sbjct: 299 KRKIVKIAAGENHLVMLDEKGCLLTFGD----GEMGQLGRSSRTKTIRSKYMCDESGDHL 354

Query: 201 -------------------IAVGAFHNLALSVDRILWAWGNNEYGQLGI-------GDTQ 302
                              +    F  +    D   +A+G N Y QLGI       G   
Sbjct: 355 LVPLRFKHKGKFFDVVAKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDG 414

Query: 303 PRSQPIRV-------EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG---- 449
             ++ +RV          +  + V+I  G  H   L  +G+V+A G+     LG G    
Sbjct: 415 QDNRELRVFLPAEAPAFGAERTFVNI-EGVQHVVILGSDGKVFAMGKNTDNALGLGNWTG 473

Query: 450 -DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 575
            DD+   +     ++     IV VS     S+  + DG  +++
Sbjct: 474 KDDQQHWLYDTIQEIEFDSKIVGVSAKLATSIAWSEDGTAYAW 516

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
 Frame = +3

Query: 249 LWAWGNNEYGQLGIGDTQPRSQPIR-VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG 425
           ++A+G+N   QLG+G  +    P R V G     +  IA GG HS  LT +G +   G  
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 426 EHGRLGFGD--DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 569
             G L       +     P++V       +V V+CG   +V++ +DGR++
Sbjct: 64  RRGELDSAQALRQVHDWRPVEVP----APVVDVACGWDTTVIVDADGRVW 109



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 34/126 (26%), Positives = 55/126 (43%), Gaps = 3/126 (2%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWGQPWPPGDIKNISTPVRVQGLEQVSMIAV-GAFHNLA 230
           V  VA G   +V++  +G VW  G     G  +     V +   ++   IAV G F N  
Sbjct: 89  VVDVACGWDTTVIVDADGRVWQRGG----GCYEFTQQHVPLNSNDE--RIAVYGCFQNFV 142

Query: 231 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGE-- 404
           +     ++ WG+N   QL    ++   +P+ V    +++ VD  A G     +  EG   
Sbjct: 143 VVQGTRVYGWGSNTKCQLQEPKSRSLKEPVLVYDTGSVA-VDYVAMGKDFMVIVDEGGRI 201

Query: 405 VYAWGR 422
           V+A GR
Sbjct: 202 VHASGR 207



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 11/20 (55%), Positives = 17/20 (85%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHV 113
           VR++A GG HSV+LT +G++
Sbjct: 38  VRKIACGGNHSVMLTNDGNL 57



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 15/39 (38%), Positives = 17/39 (43%), Gaps = 7/39 (17%)
 Frame = +3

Query: 348 LVDIAAGGWHSAALTKEGE-------VYAWGRGEHGRLG 443
           +V +A G  H    T   E       VY WG GEHG  G
Sbjct: 263 IVGVATGSEHGILTTANQEGKSHCYNVYCWGWGEHGNCG 301

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>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 39.3 bits (90), Expect = 0.008
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
 Frame = +3

Query: 261 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 428
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 382 GNNRYGQLGTGDKMDRGEPTQVCYLQR--PITLWCGLNHSLVLSQSSEFSKELLGCGCGA 439

Query: 429 HGRLGFGDDKSSHMVPLQVQL 491
            GRL      S+  V LQV++
Sbjct: 440 GGRLPGWPKGSASFVKLQVKV 460

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>POF9_SCHPO (O74381) F-box protein pof9|
          Length = 467

 Score = 34.7 bits (78), Expect(2) = 0.015
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 19/85 (22%)
 Frame = +3

Query: 192 VSMIAVGAFHNLALSVDRILWAWG--NNEYGQLGIG---------DTQPRSQPIRVEGLS 338
           +  +A G  H+L L+ D  +W+WG      G LG+G         D    S P     + 
Sbjct: 339 IKQLAHGDHHHLYLTSDHSIWSWGVELRYCGCLGLGSLHLQEQTSDPSIVSDPRTARNIV 398

Query: 339 NL--------SLVDIAAGGWHSAAL 389
           ++        +   +AAGGW SAAL
Sbjct: 399 SIPHQIHFSGTCYSVAAGGWQSAAL 423



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 5/88 (5%)
 Frame = +3

Query: 171 RVQGLEQVSMIAVGAFHN-LALSVDR-ILWAWGN---NEYGQLGIGDTQPRSQPIRVEGL 335
           RVQGL  V  +    +    A+  DR   ++WG    N  G++   +  PR +P  + G 
Sbjct: 52  RVQGLTNVVPVVDDNYKRPYAVWKDRGYAYSWGQQIRNYLGRVVNTNQYPRDRPGALTGK 111

Query: 336 SNLSLVDIAAGGWHSAALTKEGEVYAWG 419
              S + +  GG+    L + G +Y  G
Sbjct: 112 DVRSTIQVQVGGYGMYLLNENGNLYVTG 139



 Score = 22.7 bits (47), Expect(2) = 0.015
 Identities = 10/24 (41%), Positives = 11/24 (45%)
 Frame = +2

Query: 71  GWHSFSGFDTRRSCLDMGTTVASG 142
           GWH    F+T     D G TV  G
Sbjct: 294 GWHLAGSFETFTCLSDDGNTVYMG 317

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>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 37.7 bits (86), Expect = 0.024
 Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
 Frame = +3

Query: 261 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 428
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 392 GNNRYGQLGTGDKMDRGEPTQVHYLQR--PIALWCGLNHSLVLSQTSDFSKELLGCGCGA 449

Query: 429 HGRLGFGDDKSSHMVPLQVQL 491
            GRL      S+  V L +++
Sbjct: 450 GGRLPGWPKGSASFVKLHIKV 470

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>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC|
           2.7.11.1)
          Length = 901

 Score = 35.8 bits (81), Expect = 0.090
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
 Frame = +3

Query: 186 EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 362
           E VS ++ G+  N  L   +R ++ WG+      G+    PR          +L    I 
Sbjct: 160 EAVSTVSAGSVFNCGLFARNRTVFCWGDETVS--GVVGLAPR----------DLHFQSIG 207

Query: 363 AGGWHSAALTKEGEVYAWGR 422
           AGG+H   + +  +V+ WGR
Sbjct: 208 AGGYHVCGVLENAQVFCWGR 227

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 35.4 bits (80), Expect = 0.12
 Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 19/87 (21%)
 Frame = +3

Query: 186 EQVSMIAVGAFHNLALSVDRILWAWG--NNEYGQLGIGDTQPRSQPIRV---EGLSNLSL 350
           E V  +A G +H +AL+    L++WG  + + G LG+G ++     + +   EG  N+ +
Sbjct: 546 ENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEGQRNIRV 605

Query: 351 V--------------DIAAGGWHSAAL 389
           V               + AGGW + AL
Sbjct: 606 VKPTKIELPEDYICVSVTAGGWQTGAL 632



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 15/39 (38%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
 Frame = +3

Query: 339 NLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFG 449
           N +++ +A+G +H+ ALT+ G +Y+WG    + G LG G
Sbjct: 545 NENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLG 583



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 12/24 (50%), Positives = 18/24 (75%)
 Frame = +3

Query: 54  VRQVAAGGTHSVVLTQEGHVWTWG 125
           V  VA+G  H+V LT+ GH+++WG
Sbjct: 548 VISVASGDYHTVALTERGHLYSWG 571

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>UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5|
           homolog 2) (p53-regulated receptor for death and life
           protein 1)
          Length = 945

 Score = 33.1 bits (74), Expect = 0.58
 Identities = 17/49 (34%), Positives = 24/49 (48%)
 Frame = -1

Query: 567 ISGRHWLAQLNGSLHMIPEQYPLQLEAEPVVAPCGCSYHPQSRASHVLL 421
           +S R W+ QL    H    +  + L+ E +  PC C   P  RA H+LL
Sbjct: 628 VSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEP--RACHILL 674

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>TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)|
          Length = 685

 Score = 32.3 bits (72), Expect = 0.99
 Identities = 22/70 (31%), Positives = 31/70 (44%)
 Frame = +3

Query: 258 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 437
           +G  E+G  GI +      PI   G + L+ V  AAG    AAL     +Y      H  
Sbjct: 418 YGIREHGMAGIMNGLAVYGPIIPYGGTFLNFVSYAAGAVRMAALNNSRVIYV---ATHDS 474

Query: 438 LGFGDDKSSH 467
           +G G+D  +H
Sbjct: 475 IGLGEDGPTH 484

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>NAH_SCHPO (P36606) Na(+)/H(+) antiporter|
          Length = 468

 Score = 32.0 bits (71), Expect = 1.3
 Identities = 20/58 (34%), Positives = 28/58 (48%)
 Frame = -3

Query: 316 GCDLGWVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLTCSSPCTRTGVDMFLIS 143
           GC +G++         +L HA K    D+   ++ P AI L CS   T  GVD  L+S
Sbjct: 220 GCVIGYLLSF------ILKHAQKYRLIDAISYYSLPLAIPLLCSGIGTIIGVDDLLMS 271

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>TIP_RAT (Q8R4E1) T-cell immunomodulatory protein precursor (Protein TIP)|
           (CDA08-like protein)
          Length = 610

 Score = 30.8 bits (68), Expect = 2.9
 Identities = 16/53 (30%), Positives = 31/53 (58%)
 Frame = -3

Query: 301 WVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLTCSSPCTRTGVDMFLIS 143
           W + IP+    ++P+ H +  + SAKL+  P+ I+L   +    TGV +F+++
Sbjct: 531 WTAIIPNSQLMVIPYPHSVPRSWSAKLYLTPSNIVLL--TAVALTGVCVFILA 581

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>WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein|
            kinase with no lysine 1) (Protein kinase,
            lysine-deficient 1) (Kinase deficient protein)
          Length = 2382

 Score = 30.8 bits (68), Expect = 2.9
 Identities = 22/99 (22%), Positives = 42/99 (42%)
 Frame = -3

Query: 361  AMSTNERLDSPSTRIGCDLGWVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLTCSS 182
            ++ST     S ++++   L   +  P+   +++  AH +  T  +       ++    SS
Sbjct: 1491 SVSTTTSFPSTASQLSIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSS 1550

Query: 181  PCTRTGVDMFLISPGGHGCPHVQT*PSCVKTTE*VPPAA 65
                 GV  ++  PGG    H    PS + +T  +P AA
Sbjct: 1551 SSPGAGVSSYISQPGG---LHPLVIPSVIASTPILPQAA 1586

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>DLGP4_HUMAN (Q9Y2H0) Disks large-associated protein 4 (DAP-4)|
           (SAP90/PSD-95-associated protein 4) (SAPAP4)
           (PSD-95/SAP90-binding protein 4)
          Length = 989

 Score = 29.6 bits (65), Expect = 6.4
 Identities = 26/81 (32%), Positives = 34/81 (41%)
 Frame = -3

Query: 370 PPAAMSTNERLDSPSTRIGCDLGWVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLT 191
           PPA  +T      PS  +G D  +V    SW    L HAH++    SA L  +     L 
Sbjct: 270 PPAPPAT-----CPSLGVGTDTNYVKR-GSWSTLTLSHAHEVCQKTSATLDKS-----LL 318

Query: 190 CSSPCTRTGVDMFLISPGGHG 128
            S  C +     +L  PGG G
Sbjct: 319 KSKSCHQGLAYHYLQVPGGGG 339

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>DLGP4_RAT (P97839) Disks large-associated protein 4 (DAP-4)|
           (SAP90/PSD-95-associated protein 4) (SAPAP4)
           (PSD-95/SAP90-binding protein 4)
          Length = 992

 Score = 29.6 bits (65), Expect = 6.4
 Identities = 26/81 (32%), Positives = 34/81 (41%)
 Frame = -3

Query: 370 PPAAMSTNERLDSPSTRIGCDLGWVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLT 191
           PPA  +T      PS  +G D  +V    SW    L HAH++    SA L  +     L 
Sbjct: 269 PPAPPAT-----CPSLGVGTDTNYVKR-GSWSTLTLSHAHEVCQKTSATLDKS-----LL 317

Query: 190 CSSPCTRTGVDMFLISPGGHG 128
            S  C +     +L  PGG G
Sbjct: 318 KSKSCHQGLAYHYLQVPGGGG 338

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>PHLD_MOUSE (O70362) Phosphatidylinositol-glycan-specific phospholipase D 1|
           precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein
           phospholipase D) (Glycosyl-phosphatidylinositol-specific
           phospholipase D)
          Length = 837

 Score = 29.6 bits (65), Expect = 6.4
 Identities = 12/24 (50%), Positives = 14/24 (58%)
 Frame = -1

Query: 555 HWLAQLNGSLHMIPEQYPLQLEAE 484
           HW   LN S+H I E YPL  E +
Sbjct: 88  HWTPFLNASIHYIRENYPLPWEKD 111

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>YFAS_ECO57 (Q8XE35) Hypothetical UPF0192 protein yfaS precursor|
          Length = 1534

 Score = 29.3 bits (64), Expect = 8.4
 Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
 Frame = +3

Query: 363  AGGWHSAALTKEGEVYAW-GRGEHGRLGFGDDKSSHMVPLQ 482
            AG W    LT  GE + W G+G    L FGD+ S   V ++
Sbjct: 1327 AGAWAKHKLTGGGEYWRWVGQGVPDILSFGDELSPQNVQVR 1367

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>PHL2_HUMAN (Q15127) Phosphatidylinositol-glycan-specific phospholipase D 2|
           precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein
           phospholipase D) (Glycosyl-phosphatidylinositol-specific
           phospholipase D)
          Length = 841

 Score = 29.3 bits (64), Expect = 8.4
 Identities = 12/24 (50%), Positives = 14/24 (58%)
 Frame = -1

Query: 555 HWLAQLNGSLHMIPEQYPLQLEAE 484
           HW   LN S+H I E YPL  E +
Sbjct: 89  HWTPFLNASVHYIRENYPLPWEKD 112

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>PHL1_HUMAN (P80108) Phosphatidylinositol-glycan-specific phospholipase D 1|
           precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein
           phospholipase D) (Glycosyl-phosphatidylinositol-specific
           phospholipase D)
          Length = 840

 Score = 29.3 bits (64), Expect = 8.4
 Identities = 12/24 (50%), Positives = 14/24 (58%)
 Frame = -1

Query: 555 HWLAQLNGSLHMIPEQYPLQLEAE 484
           HW   LN S+H I E YPL  E +
Sbjct: 88  HWTPFLNASVHYIRENYPLPWEKD 111

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>CUBN_CANFA (Q9TU53) Cubilin precursor|
          Length = 3620

 Score = 29.3 bits (64), Expect = 8.4
 Identities = 15/52 (28%), Positives = 23/52 (44%)
 Frame = -3

Query: 343 RLDSPSTRIGCDLGWVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLTC 188
           + D P     CD GW SP+ S        +  +L  D   L +AP + ++ C
Sbjct: 234 KADEPKYNCICDAGWTSPLNS--------SACVLDIDECNLQHAPCSPLVQC 277

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>STCK_EMENI (Q00706) Putative sterigmatocystin biosynthesis fatty acid synthase|
           beta subunit
          Length = 1914

 Score = 29.3 bits (64), Expect = 8.4
 Identities = 15/44 (34%), Positives = 20/44 (45%)
 Frame = +3

Query: 6   RGRDIPIPQRCALKLKVRQVAAGGTHSVVLTQEGHVWTWGQPWP 137
           RG D+ IP  C     +R +   GTH ++LT    V      WP
Sbjct: 315 RGNDLAIPVYCQANGSLRNLQDYGTHDILLTLIQSVTVERVNWP 358


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,154,070
Number of Sequences: 219361
Number of extensions: 2113870
Number of successful extensions: 6165
Number of sequences better than 10.0: 64
Number of HSP's better than 10.0 without gapping: 5334
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5778
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 4872342800
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result