ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags10b18 |
|---|---|
| Clone Library Name | barley_pub |
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 301 bits (772), Expect = 9e-82 Identities = 147/219 (67%), Positives = 185/219 (84%), Gaps = 1/219 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCG 198 E S +K IDFGLSD+++PDERLNDIVGSAYYVAPEVLHRSYSTEAD+WS+GVI+YILLCG Sbjct: 289 EDSQLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRSYSTEADVWSIGVISYILLCG 348 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 SRPFWARTESGIFR+VL+A+ +FD+ PW S+S EAKDFVKRLLNKD RKRMTAAQAL H Sbjct: 349 SRPFWARTESGIFRAVLKANLSFDEPPWPSVSSEAKDFVKRLLNKDPRKRMTAAQALCHS 408 Query: 379 WLRD-ECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQPSS 555 W+++ PLD+LVFKL+K Y+RS+P ++AAL+ALS+ +T DEL Y + Q+ LL+P + Sbjct: 409 WIKNSNDIKFPLDILVFKLMKVYMRSSPLRKAALRALSKTLTVDELFYLKEQFVLLEP-T 467 Query: 556 QDGRICIENFRMALLQNSTDAMKESRALDILSTLEPLAY 672 ++G I +EN + AL++NSTDAMK+SR LD+L +L L Y Sbjct: 468 KNGTISLENIKQALMRNSTDAMKDSRVLDLLVSLNALQY 506
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 187 bits (474), Expect = 3e-47 Identities = 96/220 (43%), Positives = 137/220 (62%), Gaps = 2/220 (0%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYI 186 V +HE S +K IDFGLS F +PD+ D+VGS YYVAPEVL + Y EAD+WS GVI YI Sbjct: 283 VSKHEDSLLKTIDFGLSMFFKPDDVFTDVVGSPYYVAPEVLRKRYGPEADVWSAGVIVYI 342 Query: 187 LLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 LL G PFWA TE GIF VL D +F PW SIS AKD V+++L +D +KR+TA Q Sbjct: 343 LLSGVPPFWAETEQGIFEQVLHGDLDFSSDPWPSISESAKDLVRKMLVRDPKKRLTAHQV 402 Query: 367 LSHPWLR-DECCP-VPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNL 540 L HPW++ D P PLD V +K + FK+ AL+ ++ +++E+E+ + +N+ Sbjct: 403 LCHPWVQVDGVAPDKPLDSAVLSRMKQFSAMNKFKKMALRVIAESLSEEEIAGLKEMFNM 462 Query: 541 LQPSSQDGRICIENFRMALLQNSTDAMKESRALDILSTLE 660 + + + G+I E + L + + +KES LD++ + Sbjct: 463 ID-ADKSGQITFEELKAGLKRVGAN-LKESEILDLMQAAD 500
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 169 bits (429), Expect = 5e-42 Identities = 86/196 (43%), Positives = 120/196 (61%), Gaps = 1/196 (0%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILL 192 + E++ +K DFGLS FI + DIVGSAYYVAPEVL R+Y E D+WS GVI YILL Sbjct: 220 KEENAMLKATDFGLSVFIEEGKMYRDIVGSAYYVAPEVLRRNYGKEIDVWSAGVILYILL 279 Query: 193 CGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 G PFWA TE GIF ++L+ + +F+ PW SIS AKD V+++L +D +KR+T+AQ L Sbjct: 280 SGVPPFWAETEKGIFDAILQGEIDFESQPWPSISESAKDLVRKMLTQDPKKRITSAQVLQ 339 Query: 373 HPWLRD-ECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 HPWLRD E P+D V +K + K+ ALK ++ + E+E+ + + + Sbjct: 340 HPWLRDGEASDKPIDSAVLSRMKQFRAMNKLKKMALKVIASNLNEEEIKGLKQMFTNMD- 398 Query: 550 SSQDGRICIENFRMAL 597 + G I E + L Sbjct: 399 TDNSGTITYEELKAGL 414
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 162 bits (411), Expect = 7e-40 Identities = 84/195 (43%), Positives = 116/195 (59%), Gaps = 2/195 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCG 198 E++ +K DFGLS FI + DIVGSAYYVAPEVL RSY E D+WS GVI YILL G Sbjct: 202 ENAMLKATDFGLSVFIEEGKMYRDIVGSAYYVAPEVLRRSYGKEIDVWSAGVILYILLSG 261 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PFWA E GIF ++L + +F+ PW SIS AKD V+++L +D +KR+T+AQ L H Sbjct: 262 VPPFWAEIEKGIFDAILHEEIDFESQPWPSISESAKDLVRKMLTRDPKKRLTSAQVLQHQ 321 Query: 379 WLRD--ECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQPS 552 WLR+ E P+D V +K + K+ ALK ++ + E+E+ + + + + Sbjct: 322 WLREGGEASDKPIDSAVLSRMKQFRAMNKLKKMALKVIASNLNEEEIKGLKQMF-MNMDT 380 Query: 553 SQDGRICIENFRMAL 597 G I E + L Sbjct: 381 DNSGTITYEELKAGL 395
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 160 bits (404), Expect = 4e-39 Identities = 81/191 (42%), Positives = 117/191 (61%), Gaps = 2/191 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGSRPF 210 +K DFGLS FI + +IVGSAYYVAPEVL RSY E D+WS GVI YILL G PF Sbjct: 222 LKATDFGLSVFIEEGKVYRNIVGSAYYVAPEVLRRSYGKEIDIWSAGVILYILLSGVPPF 281 Query: 211 WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLRD 390 WA E GIF ++L +F+ PW S+S AKD V+++L +D R+R+T+AQ L HPW+R+ Sbjct: 282 WAENEKGIFDAILEGVIDFESEPWPSVSNSAKDLVRKMLTQDPRRRITSAQVLDHPWMRE 341 Query: 391 --ECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQPSSQDG 564 E P+D V +K + K+ ALK ++ +++E+E+ ++ + + + + G Sbjct: 342 GGEASDKPIDSAVLSRMKQFRAMNKLKQLALKVIAESLSEEEIKGLKSMFANMD-TDKSG 400 Query: 565 RICIENFRMAL 597 I E + L Sbjct: 401 TITYEELKSGL 411
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 155 bits (391), Expect = 1e-37 Identities = 80/216 (37%), Positives = 125/216 (57%), Gaps = 2/216 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCG 198 E + +K DFGLS F +P E D+VGS YYVAPEVL + Y E+D+WS GVI YILL G Sbjct: 171 EDAKLKATDFGLSVFYKPGESFCDVVGSPYYVAPEVLRKLYGPESDVWSAGVILYILLSG 230 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PFWA +E GIFR +L +F PW SIS AKD ++++L+++ + R+TA + L HP Sbjct: 231 VPPFWAESEPGIFRQILLGKLDFHSEPWPSISDSAKDLIRKMLDQNPKTRLTAHEVLRHP 290 Query: 379 WLRDE--CCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQPS 552 W+ D+ PLD V +K + K+ AL+ ++ ++E+E+ + + ++ + Sbjct: 291 WIVDDNIAPDKPLDSAVLSRLKQFSAMNKLKKMALRVIAERLSEEEIGGLKELFKMID-T 349 Query: 553 SQDGRICIENFRMALLQNSTDAMKESRALDILSTLE 660 G I + + L + ++ M ES D++ + Sbjct: 350 DNSGTITFDELKDGLKRVGSELM-ESEIKDLMDAAD 384
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 142 bits (359), Expect = 7e-34 Identities = 68/178 (38%), Positives = 105/178 (58%), Gaps = 2/178 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGSRPF 210 +K IDFGLS F +P + ++VGS YYVAPEVLH+ Y E+D+WS GVI Y+LL G PF Sbjct: 220 IKAIDFGLSVFFKPGQVFTELVGSPYYVAPEVLHKRYGPESDVWSAGVILYVLLSGVPPF 279 Query: 211 WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLRD 390 WA T+ GIF +VL+ +F PW IS AKD ++++L+ +R+ A + L HPW+ + Sbjct: 280 WAETQQGIFDAVLKGHIDFQSDPWPKISDSAKDLIRKMLSHCPSERLKAHEVLRHPWICE 339 Query: 391 E--CCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQPSSQ 558 LD V +K + K+ AL+ ++ ++E+E+ R + + ++ Sbjct: 340 NGVATDQALDPSVISRLKQFSAMNKLKKLALRVIAERLSEEEIAGLREMFKAVDTKNR 397
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 135 bits (340), Expect = 1e-31 Identities = 67/178 (37%), Positives = 103/178 (57%), Gaps = 2/178 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGSRPF 210 +K IDFGLS F RP + ++VGS YY+APEVL + Y EAD+W+ GVI Y+LL G PF Sbjct: 214 VKAIDFGLSVFFRPGQVFREVVGSPYYIAPEVLEKRYGPEADIWTAGVILYVLLTGVPPF 273 Query: 211 WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLRD 390 WA T+SGI+ VL +F + W IS AKD +K++L +R+ A + L HPW+ D Sbjct: 274 WADTQSGIYEKVLDGRIDFKSNRWPRISDSAKDLIKKMLCPYPSERLKAHEVLKHPWICD 333 Query: 391 ECCPV--PLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQPSSQ 558 LD V +K + K+ +L+ ++ ++E+E++ R + + ++ Sbjct: 334 NGVATNRALDPSVLPRLKQFSAMNRLKKLSLQIIAERLSEEEIVGLREMFKAMDTKNR 391
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 126 bits (317), Expect = 5e-29 Identities = 59/129 (45%), Positives = 87/129 (67%), Gaps = 2/129 (1%) Frame = +1 Query: 7 VLEHEHSPM--KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVIT 180 +LE++HS + K++DFGLS F D +L D +G+AYY+APEVL + Y+ + D+WS GVI Sbjct: 197 LLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVIL 256 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 YILLCG PF + + I + V + FD + W +IS EAK+ +K +L DY KR+TA Sbjct: 257 YILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAK 316 Query: 361 QALSHPWLR 387 +AL+ W++ Sbjct: 317 EALNSKWIK 325
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 126 bits (317), Expect = 5e-29 Identities = 59/129 (45%), Positives = 87/129 (67%), Gaps = 2/129 (1%) Frame = +1 Query: 7 VLEHEHSPM--KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVIT 180 +LE++HS + K++DFGLS F D +L D +G+AYY+APEVL + Y+ + D+WS GVI Sbjct: 197 LLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVIL 256 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 YILLCG PF + + I + V + FD + W +IS EAK+ +K +L DY KR+TA Sbjct: 257 YILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAK 316 Query: 361 QALSHPWLR 387 +AL+ W++ Sbjct: 317 EALNSKWIK 325
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 121 bits (304), Expect = 2e-27 Identities = 58/129 (44%), Positives = 86/129 (66%), Gaps = 2/129 (1%) Frame = +1 Query: 7 VLEHEHSPM--KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVIT 180 +LE+++S + K++DFGLS F D +L D +G+AYY+APEVL + Y+ + D+WS GVI Sbjct: 196 LLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLKKKYNEKCDVWSCGVIM 255 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 YILLCG PF + + I + V + FD + W +IS EAK+ +K +L DY KR TA Sbjct: 256 YILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAE 315 Query: 361 QALSHPWLR 387 +AL+ W++ Sbjct: 316 EALNSRWIK 324
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 115 bits (289), Expect = 9e-26 Identities = 62/153 (40%), Positives = 85/153 (55%), Gaps = 2/153 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 E S + + DFGLS P L+ G+ YVAPEVL + YS D WS+GVI YILLC Sbjct: 154 EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC 213 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ ++ +F +L+A+ FD W IS AKDF++ L+ KD KR T QAL H Sbjct: 214 GYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQH 273 Query: 376 PWLR-DECCPVPLDMLVFKLVKAYLRSTPFKRA 471 PW+ D + V + +K + +K+A Sbjct: 274 PWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQA 306
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 115 bits (289), Expect = 9e-26 Identities = 62/153 (40%), Positives = 85/153 (55%), Gaps = 2/153 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 E S + + DFGLS P L+ G+ YVAPEVL + YS D WS+GVI YILLC Sbjct: 154 EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC 213 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ ++ +F +L+A+ FD W IS AKDF++ L+ KD KR T QAL H Sbjct: 214 GYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQH 273 Query: 376 PWLR-DECCPVPLDMLVFKLVKAYLRSTPFKRA 471 PW+ D + V + +K + +K+A Sbjct: 274 PWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQA 306
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 115 bits (289), Expect = 9e-26 Identities = 62/153 (40%), Positives = 85/153 (55%), Gaps = 2/153 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 E S + + DFGLS P L+ G+ YVAPEVL + YS D WS+GVI YILLC Sbjct: 154 EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC 213 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ ++ +F +L+A+ FD W IS AKDF++ L+ KD KR T QAL H Sbjct: 214 GYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQH 273 Query: 376 PWLR-DECCPVPLDMLVFKLVKAYLRSTPFKRA 471 PW+ D + V + +K + +K+A Sbjct: 274 PWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQA 306
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 115 bits (288), Expect = 1e-25 Identities = 60/140 (42%), Positives = 80/140 (57%), Gaps = 1/140 (0%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYIL 189 + H + + DFGLS I + G+ YVAPEVL+ + Y E DMWS+GVITYIL Sbjct: 141 KENHLEVAIADFGLSKIIGQTLVMQTACGTPSYVAPEVLNATGYDKEVDMWSIGVITYIL 200 Query: 190 LCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQAL 369 LCG PF+ T IF ++ A+ F + W IS EAKDF+ +LL D KR+ A AL Sbjct: 201 LCGFPPFYGDTVPEIFEQIMEANYEFPEEYWGGISKEAKDFIGKLLVVDVSKRLNATNAL 260 Query: 370 SHPWLRDECCPVPLDMLVFK 429 +HPWL+ +D + K Sbjct: 261 NHPWLKSNNSNNTIDTVKMK 280
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 112 bits (279), Expect = 1e-24 Identities = 59/147 (40%), Positives = 83/147 (56%), Gaps = 1/147 (0%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYIL 189 + E S + + DFGLS + ++ G+ YVAPEVL + YS D WS+GVI YIL Sbjct: 155 QDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYIL 214 Query: 190 LCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQAL 369 LCG PF+ +S +F +L+A+ FD W IS AKDF++ L+ KD KR T QA Sbjct: 215 LCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAA 274 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLR 450 HPW+ + L+ + + V A +R Sbjct: 275 RHPWIAGD---TALNKNIHESVSAQIR 298
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 111 bits (278), Expect = 2e-24 Identities = 55/125 (44%), Positives = 74/125 (59%), Gaps = 1/125 (0%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYIL 189 + E S + + DFGLS + ++ G+ YVAPEVL + YS D WS+GVI YIL Sbjct: 155 QDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYIL 214 Query: 190 LCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQAL 369 LCG PF+ +S +F +L+A+ FD W IS AKDF++ L+ KD KR T QA Sbjct: 215 LCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAA 274 Query: 370 SHPWL 384 HPW+ Sbjct: 275 RHPWI 279
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 110 bits (275), Expect = 4e-24 Identities = 58/170 (34%), Positives = 96/170 (56%), Gaps = 3/170 (1%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILL 192 E++ S +K+IDFGLS + E G+ YYVAP+VL Y + D+WS GVI Y LL Sbjct: 202 ENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSGVIMYTLL 261 Query: 193 CGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 CG PF+ T++ + + V + + F ++ W SIS +AK+ + +LL + +R T +AL+ Sbjct: 262 CGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALN 321 Query: 373 HPWLRDECCP---VPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDEL 513 HPW+ V L + K +K + + K+ AL +++ + + E+ Sbjct: 322 HPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIALTIIAKHLCDVEI 371
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 110 bits (275), Expect = 4e-24 Identities = 58/170 (34%), Positives = 96/170 (56%), Gaps = 3/170 (1%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILL 192 E++ S +K+IDFGLS + E G+ YYVAP+VL Y + D+WS GVI Y LL Sbjct: 202 ENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSGVIMYTLL 261 Query: 193 CGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 CG PF+ T++ + + V + + F ++ W SIS +AK+ + +LL + +R T +AL+ Sbjct: 262 CGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALN 321 Query: 373 HPWLRDECCP---VPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDEL 513 HPW+ V L + K +K + + K+ AL +++ + + E+ Sbjct: 322 HPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIALTIIAKHLCDVEI 371
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 110 bits (274), Expect = 5e-24 Identities = 70/213 (32%), Positives = 110/213 (51%), Gaps = 5/213 (2%) Frame = +1 Query: 25 SPMKLIDFGLSD-FIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGS 201 S +K+IDFGL+ F + + G+ YYVAP+VL SY+ + DMWS GV+ YILLCG Sbjct: 253 SLIKIIDFGLASYFTHNNYEMKTKAGTPYYVAPQVLTGSYNYKCDMWSSGVLFYILLCGY 312 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF+ ++ I V + F W +IS EAKD +KR L D KR+ A++AL HPW Sbjct: 313 PPFFGESDHEILSMVKKGKYQFKGKEWNNISEEAKDLIKRCLTMDADKRICASEALQHPW 372 Query: 382 LRDECCPVPLDML----VFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 + + +DM V + K Y F++ A+ +++ + ++ ++ + +L Sbjct: 373 FKKKKYAFNMDMKMDIHVLENFKNYGLLLKFQKLAMTIIAQQSNDYDVEKLKSTFLVLDE 432 Query: 550 SSQDGRICIENFRMALLQNSTDAMKESRALDIL 648 + G I E + L D +K D+L Sbjct: 433 DGK-GYITKEQLKKGL---EKDGLKLPYNFDLL 461
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 108 bits (270), Expect = 1e-23 Identities = 59/168 (35%), Positives = 92/168 (54%), Gaps = 5/168 (2%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRP-DERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGS 201 S +K+IDFGL+ + D + G+ YYVAP+VL Y + D+WS GV+ YI+LCG Sbjct: 247 SLIKIIDFGLAAYFNDIDYEMKTKAGTPYYVAPQVLTGCYDYKCDLWSAGVLFYIILCGY 306 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF+ ++ I V + NF W +IS EAKD +KR L D KR+ A++AL HPW Sbjct: 307 PPFYGESDHEILSMVKKGKYNFKGKEWNNISDEAKDLIKRCLTIDSGKRINASEALKHPW 366 Query: 382 LRDE----CCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDEL 513 + + V +D+ V + K Y ++ A+ +++ + +L Sbjct: 367 FKKKKGSFNLDVKMDIHVLENFKNYALLLKLQKLAMTIIAQQSNDYDL 414
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 108 bits (270), Expect = 1e-23 Identities = 70/190 (36%), Positives = 101/190 (53%), Gaps = 9/190 (4%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGS 201 +P+K+ DFGLS + + + G+ Y APE+L +Y E DMWSVG+ITYILLCG Sbjct: 175 APLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGF 234 Query: 202 RPFW-ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF+ R + +FR +L + F W +S AKD VK+L+ D +KR+T QAL HP Sbjct: 235 EPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHP 294 Query: 379 WLRDECCP-VPLDMLVFKLVKAYLRSTPFKRAALKA------LSRAITEDELIYTRTQYN 537 W+ + V +D KL + R +AA+KA L A + I + + Sbjct: 295 WVTGKAANFVHMDTAQKKLQEFNARRK--LKAAVKAVVASSRLGSASSSHTSIQENHKAS 352 Query: 538 LLQPSSQDGR 567 PS+QD + Sbjct: 353 SDPPSTQDAK 362
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 107 bits (268), Expect = 3e-23 Identities = 55/127 (43%), Positives = 82/127 (64%), Gaps = 2/127 (1%) Frame = +1 Query: 13 EHEHSP-MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYI 186 +H SP +KLIDFG++ I +I G+ +VAPE++ + EADMWS+GVITYI Sbjct: 150 KHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYI 209 Query: 187 LLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 LL G+ PF T+ ++ + +FD+ ++S S AKDF++RLL KD ++RMT AQ+ Sbjct: 210 LLSGASPFLGETKQETLTNISAVNYDFDEEYFSSTSELAKDFIRRLLVKDPKRRMTIAQS 269 Query: 367 LSHPWLR 387 L H W++ Sbjct: 270 LEHSWIK 276
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 107 bits (268), Expect = 3e-23 Identities = 55/127 (43%), Positives = 82/127 (64%), Gaps = 2/127 (1%) Frame = +1 Query: 13 EHEHSP-MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYI 186 +H SP +KLIDFG++ I +I G+ +VAPE++ + EADMWS+GVITYI Sbjct: 150 KHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYI 209 Query: 187 LLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 LL G+ PF T+ ++ + +FD+ ++S S AKDF++RLL KD ++RMT AQ+ Sbjct: 210 LLSGASPFLGETKQETLTNISAVNYDFDEEYFSSTSELAKDFIRRLLVKDPKRRMTIAQS 269 Query: 367 LSHPWLR 387 L H W++ Sbjct: 270 LEHSWIK 276
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 107 bits (268), Expect = 3e-23 Identities = 54/122 (44%), Positives = 75/122 (61%), Gaps = 2/122 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGS 201 +P+K+ DFGLS + + + G+ Y APE+L +Y E DMWSVG+ITYILLCG Sbjct: 175 APLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGF 234 Query: 202 RPFW-ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF+ R + +FR +L + F W +S AKD VK+L+ D +KR+T QAL HP Sbjct: 235 EPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHP 294 Query: 379 WL 384 W+ Sbjct: 295 WV 296
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 106 bits (265), Expect = 6e-23 Identities = 53/122 (43%), Positives = 75/122 (61%), Gaps = 2/122 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGS 201 +P+K+ DFGLS + + + G+ Y APE+L +Y E DMWSVG+ITYILLCG Sbjct: 179 APLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGF 238 Query: 202 RPFW-ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF+ R + +FR +L + F W +S AKD V++L+ D +KR+T QAL HP Sbjct: 239 EPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHP 298 Query: 379 WL 384 W+ Sbjct: 299 WV 300
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 105 bits (262), Expect = 1e-22 Identities = 56/123 (45%), Positives = 74/123 (60%), Gaps = 1/123 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 E+S + + DFGLS + + ++ G+ YVAPEVL + YS D WS+GVITYILLC Sbjct: 156 ENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLC 214 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ TES +F + F+ W IS AKDF+ LL KD +R T +ALSH Sbjct: 215 GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSH 274 Query: 376 PWL 384 PW+ Sbjct: 275 PWI 277
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 104 bits (260), Expect = 2e-22 Identities = 51/120 (42%), Positives = 78/120 (65%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KLIDFG++ I +I G+ +VAPE++ + EADMWS+GVITYILL G+ P Sbjct: 157 IKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 216 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F T+ ++ + +FD+ +++ S AKDF++RLL KD ++RMT AQ+L H W++ Sbjct: 217 FLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276
>MYLK2_HUMAN (Q9H1R3) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 595 Score = 104 bits (259), Expect = 3e-22 Identities = 53/121 (43%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+IDFGL+ P+E+L G+ +++PEV+ + S + DMWS+GVITY+LL G P Sbjct: 421 VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSP 480 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F ++ +VL + FD+ + ++S EAKDFV L+ KD R RM AAQ L+HPWL Sbjct: 481 FLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLN 540 Query: 388 D 390 + Sbjct: 541 N 541
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 104 bits (259), Expect = 3e-22 Identities = 61/154 (39%), Positives = 88/154 (57%), Gaps = 3/154 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLC 195 E S + + DFGLS I+ L G+ YVAPE+L + Y D+W++GVI+YILLC Sbjct: 149 EDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLC 207 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ ++ +F +LRA FD W IS AKDF++ LL +D +KR T QAL H Sbjct: 208 GYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQH 267 Query: 376 PWLRDECCPVPLDML--VFKLVKAYLRSTPFKRA 471 W+ + + D+L V + ++ T +KRA Sbjct: 268 LWISGDAA-LDRDILGSVSEQIQKNFARTHWKRA 300
>MYLK2_MOUSE (Q8VCR8) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) (Fragment) Length = 240 Score = 103 bits (258), Expect = 4e-22 Identities = 53/121 (43%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+IDFGL+ P+E+L G+ +++PEV+ + S + DMWS+GVITY+LL G P Sbjct: 66 VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSP 125 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F ++ +VL A+ FD+ + ++S EAKDFV LL KD RM+A Q L+HPWL Sbjct: 126 FLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTKDQSARMSAEQCLAHPWLN 185 Query: 388 D 390 + Sbjct: 186 N 186
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 103 bits (257), Expect = 5e-22 Identities = 54/123 (43%), Positives = 74/123 (60%), Gaps = 1/123 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLC 195 E S + + DFGLS I+ L G+ YVAPE+L + Y D+W++GVI+YILLC Sbjct: 149 EDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLC 207 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ ++ +F +LRA FD W IS AKDF++ LL +D +KR T QAL H Sbjct: 208 GYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQH 267 Query: 376 PWL 384 W+ Sbjct: 268 LWI 270
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 103 bits (257), Expect = 5e-22 Identities = 55/123 (44%), Positives = 73/123 (59%), Gaps = 1/123 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 E+S + + DFGLS + + ++ G+ YVAPEVL + YS D WS+GVITYILLC Sbjct: 156 ENSKIMITDFGLSK-MEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLC 214 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ TES +F + F+ W IS AKDF+ LL KD +R T +AL H Sbjct: 215 GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRH 274 Query: 376 PWL 384 PW+ Sbjct: 275 PWI 277
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 103 bits (257), Expect = 5e-22 Identities = 55/123 (44%), Positives = 73/123 (59%), Gaps = 1/123 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 E+S + + DFGLS + + ++ G+ YVAPEVL + YS D WS+GVITYILLC Sbjct: 156 ENSKIMITDFGLSK-MEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLC 214 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ TES +F + F+ W IS AKDF+ LL KD +R T +AL H Sbjct: 215 GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRH 274 Query: 376 PWL 384 PW+ Sbjct: 275 PWI 277
>MYLK2_RAT (P20689) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 609 Score = 103 bits (256), Expect = 6e-22 Identities = 52/121 (42%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+IDFGL+ P+E+L G+ +++PEV+ + S + DMWS+GVITY+LL G P Sbjct: 435 VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSP 494 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F ++ +VL A+ FD+ + ++S EAKDFV L+ KD RM+A Q L+HPWL Sbjct: 495 FLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLITKDQSARMSAEQCLAHPWLN 554 Query: 388 D 390 + Sbjct: 555 N 555
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 103 bits (256), Expect = 6e-22 Identities = 54/123 (43%), Positives = 74/123 (60%), Gaps = 1/123 (0%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLC 195 E S + + DFGLS I+ L G+ YVAPE+L + Y D+W++GVI+YILLC Sbjct: 149 EDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLC 207 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF+ ++ +F +LRA FD W IS AKDF++ LL +D +KR T QAL H Sbjct: 208 GYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRH 267 Query: 376 PWL 384 W+ Sbjct: 268 LWI 270
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 102 bits (254), Expect = 1e-21 Identities = 52/120 (43%), Positives = 76/120 (63%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+IDFGL+ I +I G+ +VAPE++ + EADMWS+GVITYILL G+ P Sbjct: 157 IKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 216 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F T+ +V + F+D +++ S AKDF++RLL KD +KRMT +L HPW++ Sbjct: 217 FLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 102 bits (253), Expect = 1e-21 Identities = 51/119 (42%), Positives = 75/119 (63%), Gaps = 1/119 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KLIDFGL+ I +I G+ +VAPE++ + EADMWS+GVITYILL G+ P Sbjct: 167 IKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 226 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F T+ ++ +FD+ ++ S AKDF+++LL K+ RKR+T +AL HPW+ Sbjct: 227 FLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 285
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 102 bits (253), Expect = 1e-21 Identities = 51/119 (42%), Positives = 75/119 (63%), Gaps = 1/119 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KLIDFGL+ I +I G+ +VAPE++ + EADMWS+GVITYILL G+ P Sbjct: 167 IKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 226 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F T+ ++ +FD+ ++ S AKDF+++LL K+ RKR+T +AL HPW+ Sbjct: 227 FLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 285
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 101 bits (252), Expect = 2e-21 Identities = 50/119 (42%), Positives = 71/119 (59%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGSRPF 210 +K+IDFGLS +++ D +G+AYY+AP+VLH +Y + D+WS GVI YILL G PF Sbjct: 210 IKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPF 269 Query: 211 WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 E I + V FD + IS +AKD +K++L R++A AL H W+R Sbjct: 270 NGSNEYDILKKVETGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIR 328
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 101 bits (252), Expect = 2e-21 Identities = 50/119 (42%), Positives = 71/119 (59%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGSRPF 210 +K+IDFGLS +++ D +G+AYY+AP+VLH +Y + D+WS GVI YILL G PF Sbjct: 210 IKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPF 269 Query: 211 WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 E I + V FD + IS +AKD +K++L R++A AL H W+R Sbjct: 270 NGSNEYDILKKVETGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIR 328
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 100 bits (249), Expect = 4e-21 Identities = 49/119 (41%), Positives = 71/119 (59%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEADMWSVGVITYILLCGSRPF 210 +K+IDFGLS +++ D +G+AYY+AP+VLH +Y + D+WS GVI YILL G PF Sbjct: 210 IKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPF 269 Query: 211 WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 E I + V FD + IS +AKD +K++L R++A AL H W++ Sbjct: 270 NGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 328
>MYLK_CHICK (P11799) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin] Length = 1906 Score = 100 bits (249), Expect = 4e-21 Identities = 56/157 (35%), Positives = 86/157 (54%), Gaps = 3/157 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KLIDFGL+ + L + G+ +VAPEV+ + E DMWS+GVI YIL+ G P Sbjct: 1590 IKLIDFGLARRLESAGSLKVLFGTPEFVAPEVINYEPIGYETDMWSIGVICYILVSGLSP 1649 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F ++ +V A +FDD + IS +AKDF+ LL KD + R+ Q L HPWL+ Sbjct: 1650 FMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKSRLNCTQCLQHPWLQ 1709 Query: 388 DECCPVPLDMLVFKLVKAYLRSTPFKRA--ALKALSR 492 + + L +K Y+ +++ A++A+ R Sbjct: 1710 KDTKNMEAKKLSKDRMKKYMARRKWQKTGHAVRAIGR 1746
>MYLK2_RABIT (P07313) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 607 Score = 100 bits (249), Expect = 4e-21 Identities = 51/121 (42%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+IDFGL+ P+E+L G+ +++PEV+ + S + DMWS+GVITY+LL G P Sbjct: 433 VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSP 492 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F ++ +VL + FD+ + ++S EAKDFV L+ K+ RM+AAQ L+HPWL Sbjct: 493 FLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKEQGARMSAAQCLAHPWLN 552 Query: 388 D 390 + Sbjct: 553 N 553
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 100 bits (248), Expect = 5e-21 Identities = 51/120 (42%), Positives = 76/120 (63%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+IDFGL+ I +I G+ +VAPE++ + EADMWS+GVITYILL G+ P Sbjct: 157 IKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 216 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F T+ +V + +F++ + + S AKDF++RLL KD +KRMT +L HPW++ Sbjct: 217 FLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 100 bits (248), Expect = 5e-21 Identities = 51/135 (37%), Positives = 73/135 (54%), Gaps = 7/135 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L ++ +KL DFG S + P ERL ++ G+ Y+APE++ H Y E DMW Sbjct: 154 NILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMW 213 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 S GVI Y LL GS PFW R + + R ++ + F W S KD V R L + Sbjct: 214 STGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQ 273 Query: 343 KRMTAAQALSHPWLR 387 R TA +AL+HP+ + Sbjct: 274 NRYTAEEALAHPFFQ 288
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 99.4 bits (246), Expect = 9e-21 Identities = 51/135 (37%), Positives = 73/135 (54%), Gaps = 7/135 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L + +KL DFG S + P E+L ++ G+ Y+APE++ H Y E DMW Sbjct: 154 NILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMW 213 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 S GVI Y LL GS PFW R + + R ++ + F W S KD V R L + Sbjct: 214 STGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQ 273 Query: 343 KRMTAAQALSHPWLR 387 KR TA +AL+HP+ + Sbjct: 274 KRYTAEEALAHPFFQ 288
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 99.0 bits (245), Expect = 1e-20 Identities = 49/133 (36%), Positives = 72/133 (54%), Gaps = 7/133 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L ++ ++L DFG S + P E+L ++ G+ Y+APE+L H Y E D+W Sbjct: 158 NILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLW 217 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 + GVI + LL GS PFW R + + R ++ F W S KD + RLL D Sbjct: 218 ACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPE 277 Query: 343 KRMTAAQALSHPW 381 R+TA QAL HP+ Sbjct: 278 ARLTAEQALQHPF 290
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 99.0 bits (245), Expect = 1e-20 Identities = 52/127 (40%), Positives = 75/127 (59%), Gaps = 3/127 (2%) Frame = +1 Query: 22 HSPMKLIDFGLSDFIRPDE--RLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILL 192 +S + + DFGLS F + L G+ Y+APEV R+ Y DMW++GVITY LL Sbjct: 168 NSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGVITYFLL 227 Query: 193 CGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 G PF ++ + ++L + F+D W+ IS AKDF+K+ L D KR+TAA AL Sbjct: 228 SGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSKRLTAADALK 287 Query: 373 HPWLRDE 393 HP+L ++ Sbjct: 288 HPFLSEK 294
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 99.0 bits (245), Expect = 1e-20 Identities = 50/140 (35%), Positives = 81/140 (57%), Gaps = 4/140 (2%) Frame = +1 Query: 4 SVLEHEHSPM---KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVG 171 ++L SP+ K++DFGLS ++ E L +I+G+ YVAPE+L + S DMWS+G Sbjct: 174 NILLTSESPLGDIKIVDFGLSRIVKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIG 233 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 V+TY++L G PF + F ++ + + ++ + + ++S A DF+K+LL K R Sbjct: 234 VLTYVMLTGISPFLGDNKQETFLNISQMNLSYSEEEFDTVSESAVDFIKKLLVKKPEDRA 293 Query: 352 TAAQALSHPWLRDECCPVPL 411 TA + L HPWL P+ Sbjct: 294 TAEECLKHPWLTQSSIQDPV 313
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 99.0 bits (245), Expect = 1e-20 Identities = 53/123 (43%), Positives = 73/123 (59%), Gaps = 3/123 (2%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRP--DERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLC 195 S + + DFGL+ + D + G+ Y+APEVL R Y+ DMW++GVI YILL Sbjct: 232 SKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLS 291 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G+ PF + ++R +LR ++ PW S+S AKDF+ RLL D RMTA QAL H Sbjct: 292 GTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRH 351 Query: 376 PWL 384 PW+ Sbjct: 352 PWV 354
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 98.6 bits (244), Expect = 2e-20 Identities = 53/125 (42%), Positives = 76/125 (60%), Gaps = 3/125 (2%) Frame = +1 Query: 19 EHSPMKLIDFGL--SDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYIL 189 E S + + DFGL S D + + G+ Y+APEVL R Y++ DMW++GVITY L Sbjct: 196 EESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYAL 255 Query: 190 LCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQAL 369 L G PF +++ ++R +L+ N+ PW SIS AKDF+ +LL + RM+A QAL Sbjct: 256 LSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQAL 315 Query: 370 SHPWL 384 HPW+ Sbjct: 316 DHPWV 320
>MYLK_RABIT (P29294) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1147 Score = 98.2 bits (243), Expect = 2e-20 Identities = 58/159 (36%), Positives = 88/159 (55%), Gaps = 5/159 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR---SYSTEADMWSVGVITYILLCGS 201 +KLIDFGL+ + L + G+ +VAPEV++ SY+T DMWS+GVI YIL+ G Sbjct: 833 IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPISYAT--DMWSIGVICYILVSGL 890 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF ++ +V A +FDD + IS +AKDF+ LL KD + R+ Q L HPW Sbjct: 891 SPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW 950 Query: 382 LRDECCPVPLDMLVFKLVKAYLRSTPFKRA--ALKALSR 492 L + + L +K Y+ +++ A++A+ R Sbjct: 951 LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGR 989
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 97.8 bits (242), Expect = 3e-20 Identities = 48/123 (39%), Positives = 74/123 (60%), Gaps = 3/123 (2%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDER--LNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLC 195 S + + DFGL+ + + + G+ Y+APE+L R Y+ DMW++GVI+YILL Sbjct: 231 SKIMITDFGLASTRKKGDECLMKTTCGTPEYIAPEILVRKPYTNAVDMWALGVISYILLS 290 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G+ PF ++R +L+ +F PW S+S AKDF+ R+L D +R++A QAL H Sbjct: 291 GTMPFEDDNRMRLYRQILKGKYSFSGEPWPSVSNLAKDFIDRVLTVDPNERLSAGQALKH 350 Query: 376 PWL 384 PW+ Sbjct: 351 PWI 353
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 97.4 bits (241), Expect = 3e-20 Identities = 53/123 (43%), Positives = 73/123 (59%), Gaps = 3/123 (2%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRP--DERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLC 195 S + + DFGL+ + D + G+ Y+APEVL R Y+ DMW++GVI YILL Sbjct: 232 SKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLS 291 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G+ PF + ++R +LR ++ PW S+S AKDF+ RLL D RMTA QAL H Sbjct: 292 GTMPFEDDNRTRLYRQILRGKYSYLGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRH 351 Query: 376 PWL 384 PW+ Sbjct: 352 PWV 354
>MYLK_BOVIN (Q28824) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1176 Score = 97.1 bits (240), Expect = 4e-20 Identities = 57/159 (35%), Positives = 87/159 (54%), Gaps = 5/159 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS---YSTEADMWSVGVITYILLCGS 201 +KLIDFGL+ + L + G+ +VAPEV++ Y+T DMWS+GVI YIL+ G Sbjct: 862 IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYAT--DMWSIGVICYILVSGL 919 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF ++ +V A +FDD + IS +AKDF+ LL KD + R+ Q L HPW Sbjct: 920 SPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLNCTQCLQHPW 979 Query: 382 LRDECCPVPLDMLVFKLVKAYLRSTPFKRA--ALKALSR 492 L + + L +K Y+ +++ A++A+ R Sbjct: 980 LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGR 1018
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 97.1 bits (240), Expect = 4e-20 Identities = 48/133 (36%), Positives = 72/133 (54%), Gaps = 7/133 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L ++ ++L DFG S + P E+L ++ G+ Y+APE+L H Y E D+W Sbjct: 158 NILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLW 217 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 + GVI + LL GS PFW R + + R ++ F W S KD + +LL D Sbjct: 218 ACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNTVKDLIAKLLQVDPN 277 Query: 343 KRMTAAQALSHPW 381 R+TA QAL HP+ Sbjct: 278 ARLTAEQALQHPF 290
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 97.1 bits (240), Expect = 4e-20 Identities = 49/136 (36%), Positives = 74/136 (54%), Gaps = 7/136 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L ++ +KL DFG S ++P E+L ++ G+ Y+APE++ H Y E DMW Sbjct: 154 NILLDDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDEGHPGYGKEVDMW 213 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 S GVI Y LL GS PFW R + + R ++ F W S KD V R L + Sbjct: 214 STGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVVQPQ 273 Query: 343 KRMTAAQALSHPWLRD 390 R +A +AL+HP+ ++ Sbjct: 274 DRCSAEEALAHPFFQE 289
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 97.1 bits (240), Expect = 4e-20 Identities = 49/136 (36%), Positives = 74/136 (54%), Gaps = 7/136 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L ++ +KL DFG S ++P E+L ++ G+ Y+APE++ H Y E DMW Sbjct: 154 NILLDDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDDGHPGYGKEVDMW 213 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 S GVI Y LL GS PFW R + + R ++ F W S KD V R L + Sbjct: 214 STGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVVQPQ 273 Query: 343 KRMTAAQALSHPWLRD 390 R +A +AL+HP+ ++ Sbjct: 274 DRCSAEEALAHPFFQE 289
>MYLK_HUMAN (Q15746) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1914 Score = 96.7 bits (239), Expect = 6e-20 Identities = 57/159 (35%), Positives = 87/159 (54%), Gaps = 5/159 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS---YSTEADMWSVGVITYILLCGS 201 +KLIDFGL+ + L + G+ +VAPEV++ Y+T DMWS+GVI YIL+ G Sbjct: 1601 IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYAT--DMWSIGVICYILVSGL 1658 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF ++ +V A +FDD + IS +AKDF+ LL KD + R+ Q L HPW Sbjct: 1659 SPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW 1718 Query: 382 LRDECCPVPLDMLVFKLVKAYLRSTPFKRA--ALKALSR 492 L + + L +K Y+ +++ A++A+ R Sbjct: 1719 LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGR 1757
>MYLK_MOUSE (Q6PDN3) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1941 Score = 96.7 bits (239), Expect = 6e-20 Identities = 57/159 (35%), Positives = 87/159 (54%), Gaps = 5/159 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS---YSTEADMWSVGVITYILLCGS 201 +KLIDFGL+ + L + G+ +VAPEV++ Y+T DMWS+GVI YIL+ G Sbjct: 1623 IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYAT--DMWSIGVICYILVSGL 1680 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF ++ +V A +FDD + IS +AKDF+ LL KD + R+ Q L HPW Sbjct: 1681 SPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW 1740 Query: 382 LRDECCPVPLDMLVFKLVKAYLRSTPFKRA--ALKALSR 492 L + + L +K Y+ +++ A++A+ R Sbjct: 1741 LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGR 1779
>MYLK_SHEEP (O02827) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] (Fragment) Length = 438 Score = 95.9 bits (237), Expect = 1e-19 Identities = 57/159 (35%), Positives = 86/159 (54%), Gaps = 5/159 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS---YSTEADMWSVGVITYILLCGS 201 +KLIDFGL+ + L + G+ +VAPEV++ Y+T DMWS+GVI YIL+ G Sbjct: 123 IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYAT--DMWSIGVICYILVSGL 180 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF ++ +V A +FDD + IS +AKDF+ LL KD + R+ Q L HPW Sbjct: 181 SPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDIKNRLNCTQCLQHPW 240 Query: 382 LRDECCPVPLDMLVFKLVKAYLRSTPFKRA--ALKALSR 492 L + L +K Y+ +++ A++A+ R Sbjct: 241 LXXXTKNMEAKKLSKHRMKKYMARRKWQKTGNAVRAIGR 279
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 95.1 bits (235), Expect = 2e-19 Identities = 49/139 (35%), Positives = 78/139 (56%), Gaps = 4/139 (2%) Frame = +1 Query: 4 SVLEHEHSPM---KLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVG 171 ++L SP+ K++DFGLS ++ E L +I+G+ YVAPE+L + S DMWS+G Sbjct: 191 NILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIG 250 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 V+TY++L G PF + F ++ + + ++ + + +S A DF++ LL K R Sbjct: 251 VLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRA 310 Query: 352 TAAQALSHPWLRDECCPVP 408 TA + L HPWL P Sbjct: 311 TAEECLKHPWLTQSSIQEP 329
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 94.7 bits (234), Expect = 2e-19 Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 7/133 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-------HRSYSTEADMW 162 ++L ++ ++L DFG S + E+L ++ G+ Y+APE+L H Y E D+W Sbjct: 158 NILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLW 217 Query: 163 SVGVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYR 342 + GVI + LL GS PFW R + + R ++ F W S KD + +LL D Sbjct: 218 ACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDCSNTVKDLISKLLQVDPE 277 Query: 343 KRMTAAQALSHPW 381 R+TA QAL HP+ Sbjct: 278 ARLTAEQALQHPF 290
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 94.4 bits (233), Expect = 3e-19 Identities = 62/179 (34%), Positives = 95/179 (53%), Gaps = 2/179 (1%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYIL 189 + + S +K++DFGLS + + + GS YV+PE L R S+ +DMWS+GVI YIL Sbjct: 178 QEKRSTLKIMDFGLSSVEDFTDPIVALFGSIDYVSPEALSQRQVSSASDMWSLGVILYIL 237 Query: 190 LCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQAL 369 L G PF A + + +L D +F++ W +I+ AKD + LL+ D KR TA L Sbjct: 238 LSGCPPFHAPSNREKQQRILAGDFSFEEHTWKTITSSAKDLISSLLSVDPYKRPTANDLL 297 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKR-AALKALSRAITEDELIYTRTQYNLL 543 HPW+ + L+ V + LRS +R A++ ++ L+ T+ NLL Sbjct: 298 KHPWVIGDSAK---QELIEPEVVSRLRSFNARRKLRAAAIASVLSSKVLLRTKKLKNLL 353
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 94.0 bits (232), Expect = 4e-19 Identities = 45/120 (37%), Positives = 73/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ D++ G+ Y++PEVL + Y DMW+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAKD + ++L + KR+TA++AL HPW+ Sbjct: 213 PFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 94.0 bits (232), Expect = 4e-19 Identities = 45/120 (37%), Positives = 73/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ D++ G+ Y++PEVL + Y DMW+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAKD + ++L + KR+TA++AL HPW+ Sbjct: 213 PFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 94.0 bits (232), Expect = 4e-19 Identities = 48/122 (39%), Positives = 74/122 (60%), Gaps = 2/122 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCG 198 S + + DFGLS + P+ + G+ Y+APE++ R Y + DMW+VGVITYILL G Sbjct: 213 SKIMITDFGLSSTRKGPENFMRTTCGTPEYIAPEIIARKPYMCQVDMWAVGVITYILLSG 272 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 + PF ++ ++R +L+A ++ W +S +AKDF+ +LL R++AA AL H Sbjct: 273 TMPFDDENKTRLYRLILKAKYSYAGEHWKDVSAQAKDFIDKLLVVSPGDRLSAADALKHQ 332 Query: 379 WL 384 WL Sbjct: 333 WL 334
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 93.6 bits (231), Expect = 5e-19 Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 2/150 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFI-RPDERLNDIVGSAYYVAPEV-LHRSYSTEADMWSVGVITYILLCG 198 S + L DFG++ + P E L + GS Y APEV L + + D+WS+GVITY LLCG Sbjct: 157 SQLVLADFGIAKMLDNPAEVLTSMAGSFGYAAPEVMLKQGHGKAVDIWSLGVITYTLLCG 216 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF + + + F + W +S +AKDF+ LL D +R T+ +AL HP Sbjct: 217 YSPFRSENLTDLIEECRSGRVVFHERYWKDVSKDAKDFILSLLQVDPAQRPTSEEALKHP 276 Query: 379 WLRDECCPVPLDMLVFKLVKAYLRSTPFKR 468 WL+ E D + ++AY+ + KR Sbjct: 277 WLKGESAS---DRDLLPEIRAYIARSRLKR 303
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 92.8 bits (229), Expect = 8e-19 Identities = 45/120 (37%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ + ++ R G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 152 VKLADFGLAIEVEGEQQRWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYP 211 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAKD + ++L + KR+TAA+AL HPW+ Sbjct: 212 PFWDEDQHRLYQQIKARAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 92.0 bits (227), Expect = 1e-18 Identities = 44/120 (36%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ + +++ G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 152 VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYP 211 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAKD + ++L + KR+TAA+AL HPW+ Sbjct: 212 PFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 92.0 bits (227), Expect = 1e-18 Identities = 44/120 (36%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ + +++ G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 152 VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYP 211 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAKD + ++L + KR+TAA+AL HPW+ Sbjct: 212 PFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 92.0 bits (227), Expect = 1e-18 Identities = 44/120 (36%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ + +++ G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 152 VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYP 211 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAKD + ++L + KR+TAA+AL HPW+ Sbjct: 212 PFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 90.5 bits (223), Expect = 4e-18 Identities = 53/140 (37%), Positives = 75/140 (53%), Gaps = 1/140 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + I +VG+ Y+APEVL ++ Y+ DMWSVGVI Y+ L G+ P Sbjct: 723 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFP 782 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + I + A + +PW IS EA D + LL RKR + + LSHPWL+ Sbjct: 783 F--NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ 840 Query: 388 DECCPVPLDMLVFKLVKAYL 447 D + L L K+ + Y+ Sbjct: 841 DYQTWLDLRELECKIGERYI 860
>MKNK1_BOVIN (Q58D94) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 420 Score = 90.1 bits (222), Expect = 5e-18 Identities = 53/152 (34%), Positives = 78/152 (51%), Gaps = 29/152 (19%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSTEADMW 162 SP+K+ DF L ++ + I GSA Y+APEV+ Y D+W Sbjct: 173 SPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDEATFYDKRCDLW 232 Query: 163 SVGVITYILLCGSRPF---------WARTE------SGIFRSVLRADPNFDDSPWASISP 297 S+GV+ YI+L G PF W R E + +F S+ + F D WA IS Sbjct: 233 SLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCTVCQNKLFESIQKGKYEFPDKDWAHISN 292 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDE 393 EAKD + +LL +D ++R++AAQ L HPW++ + Sbjct: 293 EAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQ 324
>MKNK2_XENTR (Q66I46) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 466 Score = 90.1 bits (222), Expect = 5e-18 Identities = 58/165 (35%), Positives = 82/165 (49%), Gaps = 33/165 (20%) Frame = +1 Query: 16 HEHSPMKLIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLHRS------YSTEA 153 H+ SP+K+ DF L I+ + + I GSA Y+APEV+ Y Sbjct: 216 HQVSPVKICDFDLGSGIKLNSDCSPISTPELLTPCGSAEYMAPEVVEAFNEEASIYDKRC 275 Query: 154 DMWSVGVITYILLCGSRPF---------WARTESG------IFRSVLRADPNFDDSPWAS 288 D+WS+GVI YI+L G PF W R E+ +F S+ F + WA Sbjct: 276 DLWSLGVILYIMLSGYPPFVGHCGSDCGWDRGEACPACQNMLFVSIQEGKYEFPEKDWAH 335 Query: 289 ISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR----DECCPVPL 411 IS AKD + +LL +D +KR++AAQ L HPW++ D P P+ Sbjct: 336 ISSGAKDLISKLLLRDAKKRLSAAQVLQHPWVQGNAPDNTLPTPI 380
>MKNK1_RAT (Q4G050) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 413 Score = 89.7 bits (221), Expect = 7e-18 Identities = 53/152 (34%), Positives = 77/152 (50%), Gaps = 29/152 (19%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSTEADMW 162 SP+K+ DF L ++ + I GSA Y+APEV+ Y D+W Sbjct: 173 SPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLW 232 Query: 163 SVGVITYILLCGSRPF---------WARTE------SGIFRSVLRADPNFDDSPWASISP 297 S+GV+ YI+L G PF W R E + +F S+ F D WA IS Sbjct: 233 SLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHIST 292 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDE 393 EAKD + +LL +D ++R++AAQ L HPW++ + Sbjct: 293 EAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQ 324
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 89.7 bits (221), Expect = 7e-18 Identities = 50/137 (36%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +1 Query: 7 VLEHEHSP--MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 V EH+ +KL DFGL+ + D L + G+ YVAPE++ + Y + D+W+ GVI Sbjct: 519 VYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVI 576 Query: 178 TYILLCGSRPFWARTESG--IFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 TYILLCG PF + +F +L +F W ++S AK+ + +L D +R Sbjct: 577 TYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRF 636 Query: 352 TAAQALSHPWLRDECCP 402 +A Q L HPW+ D+ P Sbjct: 637 SAVQVLEHPWVNDDGLP 653
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 89.4 bits (220), Expect = 9e-18 Identities = 43/120 (35%), Positives = 71/120 (59%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ D + G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + ++ + ++ W +++PEAK+ + ++L + KR+TAA+AL HPW+ Sbjct: 213 PFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 272
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 89.4 bits (220), Expect = 9e-18 Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + I +VG+ Y+APEVL + Y+ DMWSVGVI Y+ L G+ P Sbjct: 715 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFP 774 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + I + A + +PW IS EA D + LL RKR + ++LSHPWL+ Sbjct: 775 F--NEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQ 832 Query: 388 D 390 D Sbjct: 833 D 833
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 89.4 bits (220), Expect = 9e-18 Identities = 52/156 (33%), Positives = 87/156 (55%), Gaps = 2/156 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGS 201 SP+K++DFGLS + + + GS YV+PE L + +T++DMWS+GVI YILL G Sbjct: 186 SPLKIMDFGLSSVEEFTDPVVGLFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSGY 245 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF A+ + ++ + +F + W IS AK+ + LL D KR +A + LS PW Sbjct: 246 PPFIAQNNRQKQQMIMNGNFSFYEKTWKGISQPAKNLISSLLTVDPSKRPSALELLSDPW 305 Query: 382 LRDE-CCPVPLDMLVFKLVKAYLRSTPFKRAALKAL 486 ++ E V +D + ++++ + AA+ ++ Sbjct: 306 VKGEKAKDVQMDPEIVSRLQSFNARRKLRAAAIASV 341
>MKNK1_MOUSE (O08605) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 427 Score = 89.4 bits (220), Expect = 9e-18 Identities = 53/152 (34%), Positives = 77/152 (50%), Gaps = 29/152 (19%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSTEADMW 162 SP+K+ DF L ++ + I GSA Y+APEV+ Y D+W Sbjct: 185 SPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLW 244 Query: 163 SVGVITYILLCGSRPF---------WARTE------SGIFRSVLRADPNFDDSPWASISP 297 S+GV+ YI+L G PF W R E + +F S+ F D WA IS Sbjct: 245 SLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISN 304 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDE 393 EAKD + +LL +D ++R++AAQ L HPW++ + Sbjct: 305 EAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQ 336
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 89.4 bits (220), Expect = 9e-18 Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + I +VG+ Y+APEVL ++ Y+ DMWSVGVI Y+ L G+ P Sbjct: 729 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFP 788 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + I + A + +PW IS EA D + LL RKR + + LSHPWL+ Sbjct: 789 F--NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ 846 Query: 388 D 390 D Sbjct: 847 D 847
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 89.0 bits (219), Expect = 1e-17 Identities = 43/120 (35%), Positives = 73/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ D++ G+ Y++PEVL + +Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAK+ + ++L + KR+TA +AL HPW+ Sbjct: 213 PFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV 272
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 89.0 bits (219), Expect = 1e-17 Identities = 43/120 (35%), Positives = 73/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ D++ G+ Y++PEVL + +Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAK+ + ++L + KR+TA +AL HPW+ Sbjct: 213 PFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV 272
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 89.0 bits (219), Expect = 1e-17 Identities = 43/120 (35%), Positives = 73/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ D++ G+ Y++PEVL + +Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAK+ + ++L + KR+TA +AL HPW+ Sbjct: 213 PFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV 272
>MKNK1_HUMAN (Q9BUB5) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 465 Score = 89.0 bits (219), Expect = 1e-17 Identities = 53/152 (34%), Positives = 77/152 (50%), Gaps = 29/152 (19%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSTEADMW 162 SP+K+ DF L ++ + I GSA Y+APEV+ Y D+W Sbjct: 226 SPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLW 285 Query: 163 SVGVITYILLCGSRPF---------WARTE------SGIFRSVLRADPNFDDSPWASISP 297 S+GV+ YI+L G PF W R E + +F S+ F D WA IS Sbjct: 286 SLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISS 345 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDE 393 EAKD + +LL +D ++R++AAQ L HPW++ + Sbjct: 346 EAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQ 377
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 88.6 bits (218), Expect = 2e-17 Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + I +VG+ Y+APEVL + Y+ DMWSVGVI Y+ L G+ P Sbjct: 716 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFP 775 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + I + A + +PW IS EA D + LL RKR + ++LSHPWL+ Sbjct: 776 F--NEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQ 833 Query: 388 D 390 D Sbjct: 834 D 834
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 88.2 bits (217), Expect = 2e-17 Identities = 43/120 (35%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ +++ G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAK+ + ++L + KR+TA QAL HPW+ Sbjct: 213 PFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 88.2 bits (217), Expect = 2e-17 Identities = 43/120 (35%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ +++ G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAK+ + ++L + KR+TA QAL HPW+ Sbjct: 213 PFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 88.2 bits (217), Expect = 2e-17 Identities = 49/137 (35%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +1 Query: 7 VLEHEHSP--MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 V EH+ +KL DFGL+ + D L + G+ YVAPE++ + Y + D+W+ GVI Sbjct: 212 VYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVI 269 Query: 178 TYILLCGSRPFWARTESG--IFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 TYILLCG PF + +F +L +F W ++S AK+ + +L + +R Sbjct: 270 TYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRF 329 Query: 352 TAAQALSHPWLRDECCP 402 +A Q L HPW+ D+ P Sbjct: 330 SAVQVLEHPWVNDDGLP 346
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 88.2 bits (217), Expect = 2e-17 Identities = 43/120 (35%), Positives = 72/120 (60%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFGL+ ++ +++ G+ Y++PEVL + Y D+W+ GVI YILL G Sbjct: 153 VKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYP 212 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PFW + +++ + +F W +++PEAK+ + ++L + KR+TA QAL HPW+ Sbjct: 213 PFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 88.2 bits (217), Expect = 2e-17 Identities = 49/137 (35%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +1 Query: 7 VLEHEHSP--MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 V EH+ +KL DFGL+ + D L + G+ YVAPE++ + Y + D+W+ GVI Sbjct: 535 VYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVI 592 Query: 178 TYILLCGSRPFWARTESG--IFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 TYILLCG PF + +F +L +F W ++S AK+ + +L + +R Sbjct: 593 TYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRF 652 Query: 352 TAAQALSHPWLRDECCP 402 +A Q L HPW+ D+ P Sbjct: 653 SAVQVLEHPWVNDDGLP 669
>MKNK2_HUMAN (Q9HBH9) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 465 Score = 87.4 bits (215), Expect = 4e-17 Identities = 57/155 (36%), Positives = 78/155 (50%), Gaps = 29/155 (18%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLHRS------YSTEADMW 162 SP+K+ DF L I+ + + I GSA Y+APEV+ Y D+W Sbjct: 220 SPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLW 279 Query: 163 SVGVITYILLCGSRPF---------WARTESG------IFRSVLRADPNFDDSPWASISP 297 S+GVI YILL G PF W R E+ +F S+ F D WA IS Sbjct: 280 SLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISC 339 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDECCP 402 AKD + +LL +D ++R++AAQ L HPW++ C P Sbjct: 340 AAKDLISKLLVRDAKQRLSAAQVLQHPWVQG-CAP 373
>MKNK2_XENLA (Q6P431) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 467 Score = 87.4 bits (215), Expect = 4e-17 Identities = 55/153 (35%), Positives = 78/153 (50%), Gaps = 29/153 (18%) Frame = +1 Query: 16 HEHSPMKLIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLHRS------YSTEA 153 H+ SP+K+ DF L I+ + + I GSA Y+APEV+ Y Sbjct: 216 HQVSPVKICDFDLGSGIKLNSDCSPISTPELLTPCGSAEYMAPEVVEAFNEEASIYDKRC 275 Query: 154 DMWSVGVITYILLCGSRPF---------WARTESG------IFRSVLRADPNFDDSPWAS 288 D+WS+GVI YI+L G PF W R E+ +F S+ F + WA Sbjct: 276 DLWSLGVILYIMLSGYPPFVGHCGSDCGWDRGEACPACQNMLFVSIQEGKYEFPEKDWAH 335 Query: 289 ISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 IS AKD + +LL +D +KR++AAQ L HPW++ Sbjct: 336 ISYGAKDLISKLLLRDAKKRLSAAQVLQHPWVQ 368
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 87.0 bits (214), Expect = 5e-17 Identities = 48/124 (38%), Positives = 72/124 (58%), Gaps = 1/124 (0%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGS 201 S +K++DFGLS + + + GS YV+PE L + +T++DMWS+GVI YILL G Sbjct: 194 SSLKIMDFGLSSVEEFTDPVVGLFGSIDYVSPEALSQGKITTKSDMWSLGVILYILLSGY 253 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF A+ + +L + +F + W IS AK+ + LL D KR +A + LS PW Sbjct: 254 PPFIAQNNRQKQQMILNGNFSFYEKTWKGISQSAKNLISSLLTVDPAKRPSAQELLSDPW 313 Query: 382 LRDE 393 ++ E Sbjct: 314 VKGE 317
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 87.0 bits (214), Expect = 5e-17 Identities = 46/124 (37%), Positives = 71/124 (57%), Gaps = 3/124 (2%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +KL DFGL+ + + L + G+ YVAPE++ + Y + D+W+ GVITYILLCG P Sbjct: 533 LKLGDFGLATVV--EGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPP 590 Query: 208 FWART--ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 F + + +F +L F W +I+ AK+ + ++L + R TA Q LSHPW Sbjct: 591 FRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPW 650 Query: 382 LRDE 393 + D+ Sbjct: 651 VSDD 654
>MKNK1_XENTR (Q66JF3) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 417 Score = 87.0 bits (214), Expect = 5e-17 Identities = 55/162 (33%), Positives = 79/162 (48%), Gaps = 33/162 (20%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSTEADMW 162 SP+K+ DF L ++ + I GSA Y+APEV+ Y D+W Sbjct: 173 SPVKICDFDLGSGVKLNSACTPITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLW 232 Query: 163 SVGVITYILLCGSRPF---------WARTE------SGIFRSVLRADPNFDDSPWASISP 297 S+GVI YI+L G PF W R E + +F S+ F + W+ IS Sbjct: 233 SLGVILYIMLSGYPPFVGNCGADCGWDRGEMCRVCQNKLFESIQEGKYEFPEKDWSHISN 292 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDEC----CPVPL 411 AKD + +LL +D ++R++AAQ L HPWL+ + P PL Sbjct: 293 SAKDLISKLLVRDAKERLSAAQVLQHPWLQGDAPERGLPTPL 334
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 87.0 bits (214), Expect = 5e-17 Identities = 49/132 (37%), Positives = 71/132 (53%), Gaps = 5/132 (3%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS----YSTEADMWSVGVIT 180 + E +K+ DFG S + + + G+ Y+APEVL + YS D WS+GVI Sbjct: 362 QEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSRAVDCWSLGVIL 421 Query: 181 YILLCGSRPFWA-RTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 +I L G PF +T+ + + NF W +S EA D VK+LL D + R+T Sbjct: 422 FICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTT 481 Query: 358 AQALSHPWLRDE 393 +AL+HPWL+DE Sbjct: 482 EEALNHPWLQDE 493
>KCC1_METAN (O14408) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| Length = 382 Score = 86.7 bits (213), Expect = 6e-17 Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 2/122 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCG 198 S + L DFG++ + +E L + GS Y APEV+ + + DMWS+GVITY LLCG Sbjct: 157 SDLVLADFGITKTLDIKEETLTTMAGSFGYAAPEVMEQKGHGKPVDMWSMGVITYTLLCG 216 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF + + R A F + W +S +AKDF+ LL + KR T+ +AL H Sbjct: 217 YSPFRSENLRDLLRECTAAPVPFHERYWKDVSQDAKDFILVLLVPEPEKRWTSKEALGHI 276 Query: 379 WL 384 WL Sbjct: 277 WL 278
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)| Length = 878 Score = 86.7 bits (213), Expect = 6e-17 Identities = 52/140 (37%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + I +VG+ Y+APEVL ++ Y+ DMWSVGVI Y+ L G+ P Sbjct: 691 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFP 750 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + I + A + SPW+ IS A D + LL RKR + ++LSHPWL+ Sbjct: 751 F--NEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQ 808 Query: 388 DECCPVPLDMLVFKLVKAYL 447 + + L L K+ + Y+ Sbjct: 809 EYQTWLDLRELEGKMGERYI 828
>ST17B_MOUSE (Q8BG48) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 86.3 bits (212), Expect = 8e-17 Identities = 42/120 (35%), Positives = 73/120 (60%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +K++DFG+S I L +I+G+ Y+APE+L+ +T DMW++G+I Y+LL + P Sbjct: 175 IKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSP 234 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + + ++ + ++S+S A DF++ LL K+ KR TA LSH WL+ Sbjct: 235 FVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQ 294
>ST17B_RAT (Q91XS8) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 371 Score = 86.3 bits (212), Expect = 8e-17 Identities = 42/120 (35%), Positives = 73/120 (60%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +K++DFG+S I L +I+G+ Y+APE+L+ +T DMW++G+I Y+LL + P Sbjct: 175 IKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSP 234 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + + ++ + ++S+S A DF++ LL K+ KR TA LSH WL+ Sbjct: 235 FVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQ 294
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 85.9 bits (211), Expect = 1e-16 Identities = 45/124 (36%), Positives = 71/124 (57%), Gaps = 3/124 (2%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +KL DFGL+ + + L + G+ YVAPE++ + Y + D+W+ GVITYILLCG P Sbjct: 532 LKLGDFGLATVV--EGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPP 589 Query: 208 FWART--ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 F + + +F +L F W +I+ AK+ + ++L + R TA + LSHPW Sbjct: 590 FRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPW 649 Query: 382 LRDE 393 + D+ Sbjct: 650 VSDD 653
>MKNK2_RAT (Q5U2N4) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 85.9 bits (211), Expect = 1e-16 Identities = 56/155 (36%), Positives = 78/155 (50%), Gaps = 29/155 (18%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLHRS------YSTEADMW 162 SP+K+ DF L I+ + + I GSA Y+APEV+ Y D+W Sbjct: 220 SPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLW 279 Query: 163 SVGVITYILLCGSRPF---------WARTESG------IFRSVLRADPNFDDSPWASISP 297 S+GVI YILL G PF W R E+ +F S+ F D W+ IS Sbjct: 280 SLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISF 339 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDECCP 402 AKD + +LL +D ++R++AAQ L HPW++ C P Sbjct: 340 AAKDLISKLLVRDAKQRLSAAQVLQHPWVQG-CAP 373
>MKNK2_MOUSE (Q8CDB0) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 85.9 bits (211), Expect = 1e-16 Identities = 56/155 (36%), Positives = 78/155 (50%), Gaps = 29/155 (18%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLHRS------YSTEADMW 162 SP+K+ DF L I+ + + I GSA Y+APEV+ Y D+W Sbjct: 220 SPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLW 279 Query: 163 SVGVITYILLCGSRPF---------WARTESG------IFRSVLRADPNFDDSPWASISP 297 S+GVI YILL G PF W R E+ +F S+ F D W+ IS Sbjct: 280 SLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISF 339 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDECCP 402 AKD + +LL +D ++R++AAQ L HPW++ C P Sbjct: 340 AAKDLISKLLVRDAKQRLSAAQVLQHPWVQG-CAP 373
>MAPK3_HUMAN (Q16644) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK) Length = 382 Score = 85.5 bits (210), Expect = 1e-16 Identities = 47/123 (38%), Positives = 67/123 (54%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 183 LKLTDFGFAKETTQNA-LQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPP 241 Query: 208 FWART----ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ T G+ R + F + W+ +S +AK ++ LL D +R+T Q ++H Sbjct: 242 FYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNH 301 Query: 376 PWL 384 PW+ Sbjct: 302 PWI 304
>MAPK3_RAT (Q66H84) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 85.5 bits (210), Expect = 1e-16 Identities = 48/123 (39%), Positives = 66/123 (53%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 185 LKLTDFGFAKETTQNA-LQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPP 243 Query: 208 FWART----ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ T G+ R + F WA +S +AK ++ LL D +R+T Q ++H Sbjct: 244 FYSNTGQAISPGMKRRIRLGQYGFPKPEWADVSEDAKQLIRLLLKTDPTERLTIMQFMNH 303 Query: 376 PWL 384 PW+ Sbjct: 304 PWI 306
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 85.1 bits (209), Expect = 2e-16 Identities = 49/132 (37%), Positives = 69/132 (52%), Gaps = 5/132 (3%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL----HRSYSTEADMWSVGVIT 180 + E +K+ DFG S + + + G+ Y+APEVL Y+ D WS+GVI Sbjct: 358 QEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVIL 417 Query: 181 YILLCGSRPFWA-RTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 +I L G PF RT+ + + NF WA +S +A D VK+LL D + R T Sbjct: 418 FICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTT 477 Query: 358 AQALSHPWLRDE 393 +AL HPWL+DE Sbjct: 478 EEALRHPWLQDE 489
>MAPK3_BOVIN (Q3SYZ2) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 85.1 bits (209), Expect = 2e-16 Identities = 47/123 (38%), Positives = 66/123 (53%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 185 LKLTDFGFAKETTQNA-LQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPP 243 Query: 208 FWART----ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ T G+ R + F W+ +S +AK ++ LL D +R+T Q ++H Sbjct: 244 FYSNTGQAISPGMKRRIRLGQYGFPSPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNH 303 Query: 376 PWL 384 PW+ Sbjct: 304 PWI 306
>MAPK3_MOUSE (Q3UMW7) MAP kinase-activated protein kinase 3 (EC 2.7.11.1)| (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) Length = 384 Score = 84.7 bits (208), Expect = 2e-16 Identities = 47/123 (38%), Positives = 67/123 (54%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 185 LKLTDFGFAKETTQNA-LQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPP 243 Query: 208 FWART----ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ T G+ R + +F + W +S +AK ++ LL D +R+T Q ++H Sbjct: 244 FYSNTGQAISPGMKRRIRLGQYSFPNPEWLDVSEDAKQLIRLLLKTDPTERLTIMQFMNH 303 Query: 376 PWL 384 PW+ Sbjct: 304 PWI 306
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 84.3 bits (207), Expect = 3e-16 Identities = 45/121 (37%), Positives = 72/121 (59%), Gaps = 3/121 (2%) Frame = +1 Query: 31 MKLIDFGLS--DFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGS 201 +K+ DFGL+ R + L G+ Y+APEV+ YS + D+WS+GV+ Y+LL G Sbjct: 261 IKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGE 320 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF A +E +F + + + +F+++ W SIS AK +K+L+ D R+TA + L + W Sbjct: 321 PPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQW 380 Query: 382 L 384 L Sbjct: 381 L 381
>MKNK1_XENLA (Q9YGW0) MAP kinase-interacting serine/threonine-protein kinase 1| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 418 Score = 84.3 bits (207), Expect = 3e-16 Identities = 54/162 (33%), Positives = 78/162 (48%), Gaps = 33/162 (20%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIV--------GSAYYVAPEVLH------RSYSTEADMW 162 SP+K+ DF L ++ + I GSA Y+APEV+ Y D+W Sbjct: 173 SPVKICDFDLGSGVKLNSACTTITTPELTTPCGSAEYMAPEVVEVFTEEATFYDKRCDLW 232 Query: 163 SVGVITYILLCGSRPF---------WARTE------SGIFRSVLRADPNFDDSPWASISP 297 S+GVI YI+L G PF W R E + +F S+ F + W+ IS Sbjct: 233 SLGVILYIMLSGYPPFVGNCGTDCGWDRGEVCRVCQNKLFESIQEGKYEFPEKDWSHISI 292 Query: 298 EAKDFVKRLLNKDYRKRMTAAQALSHPWLRDEC----CPVPL 411 AKD + +LL +D ++R++A Q L HPWL+ + P PL Sbjct: 293 SAKDLISKLLVRDAKERLSAFQVLQHPWLQGDAPERGLPTPL 334
>ST17B_HUMAN (O94768) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 84.0 bits (206), Expect = 4e-16 Identities = 42/120 (35%), Positives = 73/120 (60%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +K++DFG+S I L +I+G+ Y+APE+L+ +T DMW++G+I Y+LL + P Sbjct: 175 IKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSP 234 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + + ++ + ++S+S A DF++ LL K+ KR TA LSH WL+ Sbjct: 235 FVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
>UNC89_CAEEL (O01761) Muscle M-line assembly protein unc-89 (Uncoordinated protein| 89) Length = 8081 Score = 83.2 bits (204), Expect = 7e-16 Identities = 49/123 (39%), Positives = 70/123 (56%), Gaps = 2/123 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVITYILLCGSR 204 +KL DFG + + +I GS +V+PE++ RSY + DMWS GV+TY+LL G Sbjct: 6762 LKLADFGQARRLLRGLITGEIKGSPEFVSPEIV-RSYPLTLATDMWSTGVLTYVLLTGLS 6820 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF ++ +V FD SP + S +A DFVK+LL + R+T +AL HPW+ Sbjct: 6821 PFHGDNDNETLANVDSCQ--FDSSPLGNFSYDAGDFVKKLLTEIPVSRLTVDEALDHPWI 6878 Query: 385 RDE 393 DE Sbjct: 6879 NDE 6881 Score = 48.1 bits (113), Expect = 2e-05 Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 6/127 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPE--VLHRSYSTEADMWSVGVITYILLCGSR 204 +KL+DFG + + + D + +PE + + ++DMW +GV+T+ LL G Sbjct: 7917 VKLVDFGRAQKVSGAVKPVDF--DTKWASPEFHIPETPVTVQSDMWGMGVVTFCLLAGFH 7974 Query: 205 PFWAR--TESGIFRSVL--RADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 PF + E I +V+ + DPN + S E F L K +RM +ALS Sbjct: 7975 PFTSEYDREEEIKENVINVKCDPNLIP---VNASQECLSFATWALKKSPVRRMRTDEALS 8031 Query: 373 HPWLRDE 393 H +L + Sbjct: 8032 HKFLSSD 8038
>MAPK2_HUMAN (P49137) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 400 Score = 82.8 bits (203), Expect = 9e-16 Identities = 44/123 (35%), Positives = 63/123 (51%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 203 LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 262 Query: 208 FWAR----TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ G+ + F + W+ +S E K ++ LL + +RMT + ++H Sbjct: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 Query: 376 PWL 384 PW+ Sbjct: 323 PWI 325
>MAPK2_MOUSE (P49138) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 386 Score = 82.8 bits (203), Expect = 9e-16 Identities = 44/123 (35%), Positives = 63/123 (51%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 189 LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 248 Query: 208 FWAR----TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ G+ + F + W+ +S E K ++ LL + +RMT + ++H Sbjct: 249 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 308 Query: 376 PWL 384 PW+ Sbjct: 309 PWI 311
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 82.8 bits (203), Expect = 9e-16 Identities = 42/122 (34%), Positives = 73/122 (59%), Gaps = 1/122 (0%) Frame = +1 Query: 22 HSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCG 198 ++ +KL DFG S + ++ + G+ Y++PE++ R Y+ + D+W++GV+TY LL G Sbjct: 234 NNTIKLTDFGWSVYNEDGQKRKTLCGTIDYLSPELIKSREYNNKVDVWALGVLTYELLVG 293 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 S PF T+ +R +LR D F ++SP+A+D + RLL + KR+ ++ SH Sbjct: 294 SPPFEEDTKEMTYRRILRCDLKFP----LNVSPQARDLIVRLLQFEPSKRIPLSEVKSHA 349 Query: 379 WL 384 W+ Sbjct: 350 WI 351
>MAPK2_CRILO (P49136) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (P45-54 HSP27 kinase) (Fragment) Length = 329 Score = 82.8 bits (203), Expect = 9e-16 Identities = 44/123 (35%), Positives = 63/123 (51%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + L + YYVAPEVL Y DMWS+GVI YILLCG P Sbjct: 132 LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 191 Query: 208 FWAR----TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F++ G+ + F + W+ +S E K ++ LL + +RMT + ++H Sbjct: 192 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 251 Query: 376 PWL 384 PW+ Sbjct: 252 PWI 254
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 82.4 bits (202), Expect = 1e-15 Identities = 42/129 (32%), Positives = 69/129 (53%), Gaps = 2/129 (1%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS--YSTEADMWSVGVI 177 ++L + +K+IDFGLS+ R RL GS Y+ APE+L+ E D+WS G++ Sbjct: 271 NILISKTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVDVWSFGIV 330 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 Y+L+CG PF + S + + + + + +S + K + R+L D KR T Sbjct: 331 LYVLVCGKVPFDDQNMSALHAKIKKGTVEYP----SYLSSDCKGLLSRMLVTDPLKRATL 386 Query: 358 AQALSHPWL 384 + L+HPW+ Sbjct: 387 EEVLNHPWM 395
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 82.4 bits (202), Expect = 1e-15 Identities = 49/126 (38%), Positives = 67/126 (53%), Gaps = 4/126 (3%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILL 192 + SP+ + DFG++ ++ DE L GS YVAPEVL + + D+WS+GVITY LL Sbjct: 174 DESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLL 233 Query: 193 CGSRPFWARTESGIFRSVLRAD--PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 CG F A + F W S+S +AK F+ + LN D KR TAA+ Sbjct: 234 CGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAEL 293 Query: 367 LSHPWL 384 L PW+ Sbjct: 294 LEDPWI 299
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 82.4 bits (202), Expect = 1e-15 Identities = 48/128 (37%), Positives = 72/128 (56%), Gaps = 3/128 (2%) Frame = +1 Query: 7 VLEHEHSP--MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVI 177 +LE+ + P +K+IDFGL+ F+ +N GS YVAPE+L SY T+ D++S+GVI Sbjct: 237 MLENPNDPSSLKIIDFGLASFLNSPS-MNMRCGSPGYVAPEILKCASYGTKVDIFSLGVI 295 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 + +LCG PF IF+ +R +F+ W + S K+ + + K+ R TA Sbjct: 296 LFNILCGYPPFRGNNVKEIFKKNMRCHISFNTKHWINKSESVKEIILWMCCKNPDDRCTA 355 Query: 358 AQALSHPW 381 QAL H W Sbjct: 356 LQALGHQW 363
>CSKP_RAT (Q62915) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 909 Score = 82.0 bits (201), Expect = 1e-15 Identities = 44/124 (35%), Positives = 73/124 (58%), Gaps = 2/124 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCG 198 +P+KL FG++ + + VG+ +++APEV+ R Y D+W GVI +ILL G Sbjct: 156 APVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSG 215 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF+ T+ +F +++ + W+ IS AKD V+R+L D +R+T +AL+HP Sbjct: 216 CLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHP 274 Query: 379 WLRD 390 WL++ Sbjct: 275 WLKE 278
>CSKP_HUMAN (O14936) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 82.0 bits (201), Expect = 1e-15 Identities = 44/124 (35%), Positives = 73/124 (58%), Gaps = 2/124 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCG 198 +P+KL FG++ + + VG+ +++APEV+ R Y D+W GVI +ILL G Sbjct: 156 APVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSG 215 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF+ T+ +F +++ + W+ IS AKD V+R+L D +R+T +AL+HP Sbjct: 216 CLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHP 274 Query: 379 WLRD 390 WL++ Sbjct: 275 WLKE 278
>CSKP_MOUSE (O70589) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 924 Score = 82.0 bits (201), Expect = 1e-15 Identities = 44/124 (35%), Positives = 73/124 (58%), Gaps = 2/124 (1%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCG 198 +P+KL FG++ + + VG+ +++APEV+ R Y D+W GVI +ILL G Sbjct: 156 APVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSG 215 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF+ T+ +F +++ + W+ IS AKD V+R+L D +R+T +AL+HP Sbjct: 216 CLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHP 274 Query: 379 WLRD 390 WL++ Sbjct: 275 WLKE 278
>DUET_HUMAN (Q9Y2A5) Serine/threonine-protein kinase Duet (EC 2.7.11.1)| (Serine/threonine kinase with Dbl- and pleckstrin homology domain) Length = 1289 Score = 80.9 bits (198), Expect = 3e-15 Identities = 45/132 (34%), Positives = 73/132 (55%), Gaps = 4/132 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGSRP 207 +KLID + I ++ ++G+ + APEV+ S D+WS+GV+TY++L G P Sbjct: 1123 VKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSP 1182 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F ++ +V R D +F + +S A+DF+ +L +D+R+R TAA L HPWL+ Sbjct: 1183 FLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQ 1242 Query: 388 ---DECCPVPLD 414 +PLD Sbjct: 1243 PHNGSYSKIPLD 1254
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 80.5 bits (197), Expect = 4e-15 Identities = 45/135 (33%), Positives = 72/135 (53%), Gaps = 9/135 (6%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYI 186 E+++ +K+IDFG + PD + L + +Y APE+L H Y D+WS+GVI Y Sbjct: 619 ENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYT 678 Query: 187 LLCGSRPFWARTES-------GIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRK 345 +L G PF + S I + + + D +F+ W ++S EAKD ++ LL D K Sbjct: 679 MLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNK 738 Query: 346 RMTAAQALSHPWLRD 390 R+ + + WL+D Sbjct: 739 RLKMSGLRYNEWLQD 753 Score = 61.2 bits (147), Expect = 3e-09 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 9/125 (7%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLH---RSYSTEADMWSV 168 ++L + + L DFGLS +F+ + ER G+ Y+AP+++ + D WS+ Sbjct: 181 NILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 240 Query: 169 GVITYILLCGSRPFWA----RTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKD 336 GV+ Y LL G+ PF +++ I R +L+++P + +S AKD ++RLL KD Sbjct: 241 GVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQ----EMSTVAKDLLQRLLMKD 296 Query: 337 YRKRM 351 +KR+ Sbjct: 297 PKKRL 301
>RCK1_YEAST (P38622) Serine/threonine-protein kinase RCK1 (EC 2.7.11.1)| Length = 512 Score = 80.5 bits (197), Expect = 4e-15 Identities = 46/124 (37%), Positives = 65/124 (52%), Gaps = 1/124 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KL+DFGL+ +R + G+ YVA EV + YS + DMWS+G + + LLCG P Sbjct: 297 VKLMDFGLAKKLR-NNTAKTPCGTIEYVASEVFTSKRYSMKVDMWSIGCVLFTLLCGYPP 355 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F+ + E + + + R D F W +IS AK+ V LL D KR L+ PWL Sbjct: 356 FYEKNEKTLLKKISRGDYEFLAPWWDNISSGAKNAVTHLLEVDPNKRYDIDDFLNDPWLN 415 Query: 388 DECC 399 C Sbjct: 416 SYDC 419
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 80.5 bits (197), Expect = 4e-15 Identities = 43/121 (35%), Positives = 68/121 (56%), Gaps = 1/121 (0%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYST-EADMWSVGVITYILLCGS 201 SP+K++DFGLS + + + GS YV+PE L + T ++DMW++GVI YILL G Sbjct: 188 SPLKIMDFGLSSVEEFTDPVVGLFGSIDYVSPEALSQGQVTSKSDMWALGVILYILLSGY 247 Query: 202 RPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF A++ + ++ + +F + W + K + LL D KR +A + L HPW Sbjct: 248 PPFIAQSNRQKQQMIMAGEFSFYEKTWKGFLCQPKQLISSLLKVDPDKRPSAQELLDHPW 307 Query: 382 L 384 + Sbjct: 308 V 308
>OBSCN_HUMAN (Q5VST9) Obscurin (Obscurin-myosin light chain kinase)| (Obscurin-MLCK) (Obscurin-RhoGEF) Length = 7968 Score = 80.1 bits (196), Expect = 6e-15 Identities = 43/118 (36%), Positives = 69/118 (58%), Gaps = 1/118 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTEA-DMWSVGVITYILLCGSRP 207 +K+ DFG + I P E GS +V+PE++ ++ +EA D+W++GVI+Y+ L S P Sbjct: 6603 IKICDFGFAQNITPAELQFSQYGSPEFVSPEIIQQNPVSEASDIWAMGVISYLSLTCSSP 6662 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 F ++ +VL ++ A +S +AKDF+K L + + R +AAQ LSHPW Sbjct: 6663 FAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQRAPQARPSAAQCLSHPW 6720 Score = 40.8 bits (94), Expect = 0.004 Identities = 38/163 (23%), Positives = 76/163 (46%), Gaps = 10/163 (6%) Frame = +1 Query: 19 EHSPMKLIDFGLS-----DFIRPDERLNDIVGSAYYVAPEVLHRSYST-EADMWSVGVIT 180 E++ +K++D G + + + P ++ D + + +APE+L + + D+W++GV Sbjct: 7801 EYNLLKVVDLGNAQSLSQEKVLPSDKFKDYLET---MAPELLEGQGAVPQTDIWAIGVTA 7857 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 +I+L P + + R + + +A +S A F++ L R A+ Sbjct: 7858 FIMLSAEYPVSSEGARDLQRGLRKGLVRLSRC-YAGLSGGAVAFLRSTLCAQPWGRPCAS 7916 Query: 361 QALSHPWLRDE--CC--PVPLDMLVFKLVKAYLRSTPFKRAAL 477 L PWL +E C P P+ +L + ++R+ +RA L Sbjct: 7917 SCLQCPWLTEEGPACSRPAPVTFPTARL-RVFVRNREKRRALL 7958
>MAPK2_DROME (P49071) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) Length = 359 Score = 80.1 bits (196), Expect = 6e-15 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 5/126 (3%) Frame = +1 Query: 22 HSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCG 198 ++ +KL DFG + L + YYVAPEVL Y D+WS+GV+ YI++CG Sbjct: 156 NATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCG 215 Query: 199 SRPFWAR----TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 PF++ G+ + +F D W ++S AKD +K +LN D KR+ Sbjct: 216 FPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDV 275 Query: 367 LSHPWL 384 +S+ W+ Sbjct: 276 ISNKWI 281
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 80.1 bits (196), Expect = 6e-15 Identities = 47/139 (33%), Positives = 81/139 (58%), Gaps = 5/139 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIR--PDERLNDIVGSAYYVAPEVLH-RSY-STEADMWSVG 171 ++L E+ +KLIDFGL + D L GS Y APE++ +SY +EAD+WS+G Sbjct: 137 NLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMG 196 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 ++ Y+L+CG PF +++ ++R ++ W +SP + ++++L D +KR+ Sbjct: 197 ILLYVLMCGFLPFDDDNVMALYKKIMRG--KYEVPKW--LSPSSILLLQQMLQVDPKKRI 252 Query: 352 TAAQALSHPW-LRDECCPV 405 + L+HPW ++D CPV Sbjct: 253 SMRNLLNHPWVMQDYSCPV 271
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 79.7 bits (195), Expect = 7e-15 Identities = 44/133 (33%), Positives = 67/133 (50%), Gaps = 14/133 (10%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH--------------RSYSTEADMWSV 168 +K+ DFGL+ + G+ YVAPEV+ YS+ DMWS+ Sbjct: 335 VKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSM 394 Query: 169 GVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 G + Y++L G PF T+ +++ + R + IS EA+DF+ LL D R Sbjct: 395 GCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNR 454 Query: 349 MTAAQALSHPWLR 387 TAA+AL+HPW++ Sbjct: 455 STAAKALNHPWIK 467
>MAPK5_HUMAN (Q8IW41) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase) Length = 473 Score = 79.0 bits (193), Expect = 1e-14 Identities = 46/144 (31%), Positives = 69/144 (47%), Gaps = 24/144 (16%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-------------------SYST 147 +P+KL DFG + + D + YYVAP+VL +Y+ Sbjct: 163 APVKLCDFGFAKIDQGDLMTPQF--TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNK 220 Query: 148 EADMWSVGVITYILLCGSRPFWARTESGIF-----RSVLRADPNFDDSPWASISPEAKDF 312 D+WS+GVI Y++LCG PF+++ S R ++ F + W+ IS AKD Sbjct: 221 SCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDV 280 Query: 313 VKRLLNKDYRKRMTAAQALSHPWL 384 V++LL +R+T L HPWL Sbjct: 281 VRKLLKVKPEERLTIEGVLDHPWL 304
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 79.0 bits (193), Expect = 1e-14 Identities = 44/135 (32%), Positives = 74/135 (54%), Gaps = 9/135 (6%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYI 186 E+++ +K+IDFG + PD + L + +Y APE+L+++ Y D+WS+GVI Y Sbjct: 555 ENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYT 614 Query: 187 LLCGSRPFWARTES-------GIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRK 345 +L G PF + S I + + + D +F+ W ++S EAKD ++ LL D K Sbjct: 615 MLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNK 674 Query: 346 RMTAAQALSHPWLRD 390 R+ + + WL+D Sbjct: 675 RLKMSGLRYNEWLQD 689 Score = 61.6 bits (148), Expect = 2e-09 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 9/125 (7%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLH---RSYSTEADMWSV 168 ++L + + L DFGLS +F+ + ER G+ Y+AP+++ + D WS+ Sbjct: 182 NILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 241 Query: 169 GVITYILLCGSRPFWA----RTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKD 336 GV+ Y LL G+ PF +++ I R +L+++P + +S AKD ++RLL KD Sbjct: 242 GVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQ----EMSALAKDLIQRLLMKD 297 Query: 337 YRKRM 351 +KR+ Sbjct: 298 PKKRL 302
>SRK1_SCHPO (O94547) Serine/threonine-protein kinase srk1 (EC 2.7.11.1)| (Sty1-regulated kinase 1) Length = 580 Score = 79.0 bits (193), Expect = 1e-14 Identities = 43/119 (36%), Positives = 62/119 (52%), Gaps = 1/119 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 ++L DFGLS + D G+ Y APE++ YS DMW++G + Y +LCG P Sbjct: 304 IRLADFGLSKVVW-DSHTQTPCGTMGYTAPEIVRDERYSKGVDMWALGCVLYTILCGFPP 362 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F+ + S + + V R + +F W IS AKD + LL D R Q L+HPW+ Sbjct: 363 FYDESISLLTKKVSRGEYSFLSPWWDDISKSAKDLISHLLTVDPESRYDIHQFLAHPWI 421
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/126 (37%), Positives = 68/126 (53%), Gaps = 4/126 (3%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILL 192 E+SP+ + DFG++ ++ +E L GS YVAPEVL + + D+WS+GVITY LL Sbjct: 184 ENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLL 243 Query: 193 CGSRPFWARTESGIFR--SVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 CG PF A + G + R F W +IS + K F+ + L + R TA + Sbjct: 244 CGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATEL 303 Query: 367 LSHPWL 384 L PW+ Sbjct: 304 LDDPWI 309
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 78.6 bits (192), Expect = 2e-14 Identities = 43/135 (31%), Positives = 73/135 (54%), Gaps = 9/135 (6%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYI 186 E ++S +K+IDFG + PD + L + +Y APE+ H Y D+WS+GVI Y Sbjct: 545 ETDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELFNHNGYDESCDLWSLGVILYT 604 Query: 187 LLCGSRPFWARTES-------GIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRK 345 +L G PF ++ +S I + + + + +F+ W ++S EAK+ ++ LL D K Sbjct: 605 MLSGQVPFQSQDKSLTCTSALEIMKKIKKGEFSFEGEAWKNVSEEAKELIQGLLTVDPNK 664 Query: 346 RMTAAQALSHPWLRD 390 R+ + + WL+D Sbjct: 665 RIKMSSLRYNEWLQD 679 Score = 61.6 bits (148), Expect = 2e-09 Identities = 50/157 (31%), Positives = 77/157 (49%), Gaps = 14/157 (8%) Frame = +1 Query: 37 LIDFGLSDFIRPDE--RLNDIVGSAYYVAPEVLH---RSYSTEADMWSVGVITYILLCGS 201 L DFGLS DE R G+ Y+AP+++ + D WSVGV+ Y LL G+ Sbjct: 183 LTDFGLSKEFLTDENERAYSFCGTIEYMAPDIVRGGDTGHDKAVDWWSVGVLMYELLTGA 242 Query: 202 RPFWA----RTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM-----T 354 PF +++ I R +L+++P + +S +KD ++RLL KD +KR+ Sbjct: 243 SPFTVDGEKNSQAEISRRILKSEPPYPQ----EMSALSKDIIQRLLMKDPKKRLGCGPTD 298 Query: 355 AAQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFK 465 A + HP+ ++ + D L K V A PFK Sbjct: 299 ADEIKQHPFFQN----INWDDLAAKKVPA-----PFK 326
>MEK1_YEAST (P24719) Meiosis-specific serine/threonine-protein kinase MEK1 (EC| 2.7.11.1) Length = 497 Score = 78.2 bits (191), Expect = 2e-14 Identities = 48/136 (35%), Positives = 68/136 (50%), Gaps = 20/136 (14%) Frame = +1 Query: 37 LIDFGLS-DFIRPDERLNDIVGSAYYVAPEV------------------LHRSYSTEADM 159 L DFG++ D ER++ +VG+ Y APEV R Y ++ D+ Sbjct: 309 LADFGIAKDLNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKCDL 368 Query: 160 WSVGVITYILLCGSRPFWAR-TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKD 336 WS+GVIT+I+L G PF+ +E I ++ NF W +S AK FVK LL D Sbjct: 369 WSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTD 428 Query: 337 YRKRMTAAQALSHPWL 384 KR+ + Q L H W+ Sbjct: 429 VVKRLNSKQGLKHIWI 444
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 77.8 bits (190), Expect = 3e-14 Identities = 44/134 (32%), Positives = 77/134 (57%), Gaps = 4/134 (2%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIR--PDERLNDIVGSAYYVAPEVLH-RSY-STEADMWSVG 171 ++L E+ +KLIDFGL + D L GS Y APE++ +SY +EAD+WS+G Sbjct: 137 NLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMG 196 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 ++ Y+L+CG PF +++ ++R +D W +SP + ++++L D +KR+ Sbjct: 197 ILLYVLMCGFLPFDDDNVMALYKKIMRG--KYDVPKW--LSPSSILLLQQMLQVDPKKRI 252 Query: 352 TAAQALSHPWLRDE 393 + L+HPW+ + Sbjct: 253 SMKNLLNHPWIMQD 266
>MAPK5_MOUSE (O54992) MAP kinase-activated protein kinase 5 (EC 2.7.11.1)| (MAPK-activated protein kinase 5) (MAPKAP kinase 5) Length = 473 Score = 77.4 bits (189), Expect = 4e-14 Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 24/144 (16%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHR-------------------SYST 147 +P+KL DFG + + D + YYVAP+VL +Y+ Sbjct: 163 APVKLCDFGFAKVDQGDLMTPQF--TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNK 220 Query: 148 EADMWSVGVITYILLCGSRPFWARTESGIF-----RSVLRADPNFDDSPWASISPEAKDF 312 D+WS+GVI Y++LCG PF+++ S + ++ F + W+ IS AKD Sbjct: 221 SCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEMAKDV 280 Query: 313 VKRLLNKDYRKRMTAAQALSHPWL 384 V++LL +R+T L HPWL Sbjct: 281 VRKLLKVKPEERLTIEGVLDHPWL 304
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 77.4 bits (189), Expect = 4e-14 Identities = 44/135 (32%), Positives = 74/135 (54%), Gaps = 9/135 (6%) Frame = +1 Query: 13 EHEHSPMKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYI 186 E+++ +K+IDFG + PD + L + +Y APE+L+++ Y D+WS+GVI Y Sbjct: 555 ENDNLEIKIIDFGFARPKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYT 614 Query: 187 LLCGSRPFWARTES-------GIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRK 345 +L G PF + S I + + + D +F+ W ++S EAKD ++ LL D K Sbjct: 615 MLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNK 674 Query: 346 RMTAAQALSHPWLRD 390 R+ + + WL+D Sbjct: 675 RLKMSGLRYNEWLQD 689 Score = 60.1 bits (144), Expect = 6e-09 Identities = 39/125 (31%), Positives = 68/125 (54%), Gaps = 9/125 (7%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLH---RSYSTEADMWSV 168 ++L + + L DFGLS +F+ + ER G+ Y+AP+++ + D WS+ Sbjct: 182 NILLDSNGHVMLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 241 Query: 169 GVITYILLCGSRPFWA----RTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKD 336 GV+ Y LL G+ PF +++ I R +L+++P + +S AKD ++ LL KD Sbjct: 242 GVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQ----EMSALAKDLIQHLLMKD 297 Query: 337 YRKRM 351 +KR+ Sbjct: 298 PKKRL 302
>MEK1_SCHPO (Q10292) Meiosis-specific serine/threonine-protein kinase mek1 (EC| 2.7.11.1) Length = 445 Score = 77.4 bits (189), Expect = 4e-14 Identities = 44/127 (34%), Positives = 63/127 (49%), Gaps = 12/127 (9%) Frame = +1 Query: 37 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH------------RSYSTEADMWSVGVIT 180 L DFG++ ++ +RL+ VG+ Y APE+ Y E D+WS+GVI Sbjct: 301 LTDFGVARCMQKGKRLSTFVGTPEYTAPEIQRLKGRSQVEKENSSGYGKEVDLWSLGVIM 360 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 ++LL G+ P +A V +F D W S+S +AKD + LL + R T Sbjct: 361 FLLLSGNSPSFAD-------GVKEKQVDFRDPVWKSVSRQAKDLISNLLKTNPPDRFTVK 413 Query: 361 QALSHPW 381 Q LSHPW Sbjct: 414 QCLSHPW 420
>TRIO_HUMAN (O75962) Triple functional domain protein (PTPRF-interacting protein)| Length = 3038 Score = 76.3 bits (186), Expect = 8e-14 Identities = 44/120 (36%), Positives = 68/120 (56%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + + ++ ++G+ + APE+ L S +D WSVGV+TY+LL G P Sbjct: 2873 IKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSP 2932 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ R D +F D + +S +AK+FV LL +D KR +AA AL WL+ Sbjct: 2933 FLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQ 2992
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 75.9 bits (185), Expect = 1e-13 Identities = 40/128 (31%), Positives = 67/128 (52%), Gaps = 4/128 (3%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL----HRSYSTEADMWSVGVITYI 186 E + +K+ DFGLS F++ D + + G+ YVAPEVL +Y+ + D+WS+GV+ + Sbjct: 316 EETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFT 375 Query: 187 LLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 L G+ PF + + + + + W S+S AK + ++L D +R + Sbjct: 376 CLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDV 435 Query: 367 LSHPWLRD 390 L WLRD Sbjct: 436 LQSSWLRD 443
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 75.5 bits (184), Expect = 1e-13 Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 2/122 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFGL+ F + N + G+ YVAPEVL + Y+++ D+WS GVI Y+ LCG P Sbjct: 361 VKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPP 420 Query: 208 FWART-ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F + + +L+A F W I + LL + +R +AL+HPW Sbjct: 421 FSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWF 480 Query: 385 RD 390 D Sbjct: 481 ND 482
>CSK21_RAT (P19139) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
>CSK21_RABIT (P33674) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
>CSK21_HUMAN (P68400) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
>CSK21_CHICK (P21868) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
>CSK21_BOVIN (P68399) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
>CSK22_XENLA (P28020) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 392 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQTRLTAREAMDHPY 323
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 75.1 bits (183), Expect = 2e-13 Identities = 41/121 (33%), Positives = 66/121 (54%), Gaps = 2/121 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEA-DMWSVGVITYILLCGSR 204 +KL DFG S+ +P ++L GS Y APE+L Y A D+WS+GVI ++L+CG Sbjct: 154 VKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQP 213 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF +S ++ + +S E KD + R+L +D ++R + + +HPWL Sbjct: 214 PFQEANDSETLTMIMDCKYTVP----SHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269 Query: 385 R 387 + Sbjct: 270 Q 270
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 75.1 bits (183), Expect = 2e-13 Identities = 43/121 (35%), Positives = 61/121 (50%), Gaps = 2/121 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVITYILLCGSR 204 +K+ DFGLS+ +R L GS Y APEV+ E D+WS GVI Y LLCG+ Sbjct: 179 VKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTL 238 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF +F+ + + +SP A+D + R+L D KR+T + HPW Sbjct: 239 PFDDENIPNLFKKIKGGIYTLP----SHLSPGARDLIPRMLVVDPMKRVTIPEIRQHPWF 294 Query: 385 R 387 + Sbjct: 295 Q 295
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 75.1 bits (183), Expect = 2e-13 Identities = 44/131 (33%), Positives = 73/131 (55%), Gaps = 5/131 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVLHRS--YSTEADMWSV 168 ++L E+ +K+ DFGLS D IRPD L+ + G+ YVAPE+L + + D+WS Sbjct: 150 NLLIDENGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILSKKGYEGAKVDVWSC 209 Query: 169 GVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 G++ ++L+ G PF +++ + + + F W +SP+ K FV RLL+ + R Sbjct: 210 GIVLFVLVAGYLPFNDPNVMNMYKKIYKGEYRF--PRW--MSPDLKRFVSRLLDINPETR 265 Query: 349 MTAAQALSHPW 381 +T + L PW Sbjct: 266 ITIDEILKDPW 276
>LIN2_CAEEL (P54936) Protein lin-2 (Abnormal cell lineage protein 2)| Length = 961 Score = 75.1 bits (183), Expect = 2e-13 Identities = 45/132 (34%), Positives = 78/132 (59%), Gaps = 9/132 (6%) Frame = +1 Query: 25 SPMKLIDFGLSDFIRPDERLNDI--------VGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 +P+KL FG++ + L++I VG ++APE++ + S +D+WS GV+ Sbjct: 161 APLKLCGFGVA------KDLSEIGGSMACGRVGVPQFMAPEIVRKDRVSCSSDIWSSGVV 214 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 ++LL G PF T S I+ +++ D + D +IS A++ V+R+LN D KR++A Sbjct: 215 LFLLLAGRLPFSGST-SDIYERIMQTDVDVDGY-MPNISESARNLVRRMLNADPSKRISA 272 Query: 358 AQALSHPWLRDE 393 +AL+H W+RD+ Sbjct: 273 KEALNHEWIRDK 284
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 74.7 bits (182), Expect = 2e-13 Identities = 41/129 (31%), Positives = 69/129 (53%), Gaps = 1/129 (0%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVIT 180 ++L + +K+ DFG S P R + G+ Y+ PE++ R + + D+WS+GV+ Sbjct: 252 NLLLGSNGELKIADFGWSVHA-PSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLC 310 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 Y L G PF A T +R + R + F D ++ A+D + RLL + +R+T A Sbjct: 311 YEFLVGMPPFEAHTYQETYRRISRVEFTFPD----FVTEGARDLISRLLKHNASQRLTLA 366 Query: 361 QALSHPWLR 387 + L HPW++ Sbjct: 367 EVLEHPWIK 375
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 74.3 bits (181), Expect = 3e-13 Identities = 44/133 (33%), Positives = 73/133 (54%), Gaps = 5/133 (3%) Frame = +1 Query: 1 YSVLEHEHSPMKLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGV 174 +++ + + S ++++DFG + R + L +A +VAPEVL + Y D+WS+GV Sbjct: 580 FALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGV 639 Query: 175 ITYILLCGSRPFWAR---TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRK 345 + + +L G PF T I + V + W +IS EAKD V+++L+ D + Sbjct: 640 LLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNR 699 Query: 346 RMTAAQALSHPWL 384 R+TA QAL H W+ Sbjct: 700 RVTAKQALQHKWI 712 Score = 57.0 bits (136), Expect = 5e-08 Identities = 35/114 (30%), Positives = 63/114 (55%), Gaps = 5/114 (4%) Frame = +1 Query: 31 MKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVITYILLCGSR 204 +K+ DFGLS + I +++ G+ Y+APEV++R +S AD WS+GV+ + +L G Sbjct: 243 IKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHL 302 Query: 205 PFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 PF R + +L+A P+F ++ EA+ ++ L ++ + R+ A Sbjct: 303 PFQGRDRNDTMTQILKAKLSMPHF-------LTQEAQSLLRALFKRNSQNRLGA 349
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/133 (34%), Positives = 71/133 (53%), Gaps = 5/133 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSY-STEADMWSVGVI 177 ++L + +KL DFG +F +P E L+ VGS Y APEV + Y + D+WS+GV+ Sbjct: 154 NLLLDSNMDIKLADFGFGNFYKPGEPLSTCVGSPPYAAPEVFEGKEYEGPQLDVWSLGVV 213 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 Y+L+CGS PF + + VL P F +S + + ++R+L D KR Sbjct: 214 LYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFF-------MSQDCETLIRRMLVVDPAKR 266 Query: 349 MTAAQALSHPWLR 387 +T AQ H W++ Sbjct: 267 ITIAQIRQHRWMQ 279
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 73.9 bits (180), Expect = 4e-13 Identities = 38/119 (31%), Positives = 67/119 (56%), Gaps = 1/119 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG S + + G+ Y++PE++ R Y + D+W++GV+ Y L+ G P Sbjct: 237 VKLADFGWSILNPEGSKRKTLCGTIDYLSPEMITPREYDEQVDVWALGVLAYELVVGVPP 296 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F ++ ++ +L+ D NF + SIS +AKD + +LL D +R++ +HPW+ Sbjct: 297 FEENSKELTYKRILKCDLNFPE----SISKDAKDLISKLLVTDTTQRLSLTGVKTHPWI 351
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 73.9 bits (180), Expect = 4e-13 Identities = 42/121 (34%), Positives = 67/121 (55%), Gaps = 2/121 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSTEA-DMWSVGVITYILLCGSR 204 +KL DFG S+ +P ++L GS Y APE+ L Y A D+WS+GVI ++L+CG Sbjct: 154 VKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQP 213 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF +S ++ D + P +S +D + R+L +D ++R + + SHPWL Sbjct: 214 PFQEANDSETLTMIM--DCKYTVPP--RVSAGCRDLITRMLQRDPKRRASLEEIESHPWL 269 Query: 385 R 387 + Sbjct: 270 Q 270
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 73.9 bits (180), Expect = 4e-13 Identities = 41/129 (31%), Positives = 68/129 (52%), Gaps = 1/129 (0%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVIT 180 ++L + +K+ DFG S P R + G+ Y PE++ R + + D+WS+GV+ Sbjct: 254 NLLLGSNGELKIADFGWSVHA-PSSRRTTLCGTLDYQPPEMIEGRMHDEKVDLWSLGVLC 312 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 Y L G PF A T +R + R + F D ++ A+D + RLL + +R+T A Sbjct: 313 YEFLVGMPPFEAHTYQETYRRISRVEFTFPD----FVTEGARDLISRLLKHNSSQRLTLA 368 Query: 361 QALSHPWLR 387 + L HPW++ Sbjct: 369 EVLEHPWIK 377
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 73.9 bits (180), Expect = 4e-13 Identities = 42/121 (34%), Positives = 67/121 (55%), Gaps = 2/121 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEV-LHRSYSTEA-DMWSVGVITYILLCGSR 204 +KL DFG S+ +P ++L GS Y APE+ L Y A D+WS+GVI ++L+CG Sbjct: 154 VKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQP 213 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF +S ++ D + P +S +D + R+L +D ++R + + SHPWL Sbjct: 214 PFQEANDSETLTMIM--DCKYTVPP--RVSAGCRDLITRMLQRDPKRRASLEEIESHPWL 269 Query: 385 R 387 + Sbjct: 270 Q 270
>CAKI_DROME (Q24210) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CAKI) (Peripheral plasma membrane protein CaMGUK) Length = 898 Score = 73.6 bits (179), Expect = 5e-13 Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 6/128 (4%) Frame = +1 Query: 25 SPMKLIDFGLSDFI---RPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILL 192 +P+KL FG + + R + VG +Y+APEV+ R Y D+W GV+ ++LL Sbjct: 156 APVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLL 215 Query: 193 CGSRPFWARTESGIF--RSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQA 366 G PF SG+ +SV R +F+ W SIS AKD V ++L + R++ + Sbjct: 216 SGRLPFLG---SGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEV 272 Query: 367 LSHPWLRD 390 L HPW+RD Sbjct: 273 LDHPWIRD 280
>CSK21_MOUSE (Q60737) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 73.6 bits (179), Expect = 5e-13 Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HEH ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES------------------GIFRSVLRADPNFDD-------SPWA 285 ++ PF+ ++ I + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ +LL D++ R+T +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTVREAMEHPF 323
>PAK6_HUMAN (Q9NQU5) Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1)| (p21-activated kinase 6) (PAK-6) (PAK-5) Length = 681 Score = 73.2 bits (178), Expect = 7e-13 Identities = 48/138 (34%), Positives = 77/138 (55%), Gaps = 5/138 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +KL DFG I D + +VG+ Y++APEV+ RS Y+TE D+WS+G++ ++ G Sbjct: 540 VKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEP 599 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 P+++ + + LR P +SP +DF++R+L +D ++R TA + L HP+L Sbjct: 600 PYFSDSPVQAMKR-LRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 658 Query: 385 RDEC---CPVPLDMLVFK 429 C VPL L K Sbjct: 659 LQTGLPECLVPLIQLYRK 676
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 73.2 bits (178), Expect = 7e-13 Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 7/149 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+GV+ Y +L G Sbjct: 553 LRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYT 612 Query: 205 PFW---ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + T I + W ++S AKD V ++L+ D +R+TA Q L H Sbjct: 613 PFANGPSDTPEEILTRISSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 672 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRST 456 PW+ +D+ L +LVK + +T Sbjct: 673 PWITQKDKLPQSQLSHQDLQLVKGGMAAT 701 Score = 55.8 bits (133), Expect = 1e-07 Identities = 38/121 (31%), Positives = 62/121 (51%), Gaps = 5/121 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRSYSTE-ADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R T AD WS GV+ Sbjct: 192 NILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVL 251 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L GS PF + +L+A P F +S EA+ ++ L ++ R Sbjct: 252 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF-------LSTEAQSLLRALFKRNPANR 304 Query: 349 M 351 + Sbjct: 305 L 305
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha| 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 72.8 bits (177), Expect = 9e-13 Identities = 51/151 (33%), Positives = 73/151 (48%), Gaps = 7/151 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R L +A +VAPEVL R Y D+WS+G++ Y +L G Sbjct: 550 IRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFT 609 Query: 205 PFWAR---TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T I + W SIS AKD V ++L+ D +R+TA Q L H Sbjct: 610 PFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKH 669 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRSTPF 462 PW+ R+ P L LVK + +T F Sbjct: 670 PWVVNREYLSPNQLSRQDVHLVKGAMAATYF 700 Score = 57.4 bits (137), Expect = 4e-08 Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 5/123 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRSYSTE-ADMWSVGVI 177 ++L E +K+ DFGLS + I D+R G+ Y+APEV++R T+ AD WS GV+ Sbjct: 189 NILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVL 248 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L GS PF + +L+A P F +S EA+ ++ L ++ R Sbjct: 249 MFEMLTGSLPFQGKDRKETMALILKAKLGMPQF-------LSGEAQSLLRALFKRNPCNR 301 Query: 349 MTA 357 + A Sbjct: 302 LGA 304
>ATG1_YEAST (P53104) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Autophagy protein 3) (Cytoplasm to vacuole targeting protein 10) Length = 897 Score = 72.8 bits (177), Expect = 9e-13 Identities = 35/108 (32%), Positives = 61/108 (56%), Gaps = 1/108 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG + F+ + GS Y+APE+L ++ Y+ +AD+WSVG + + + CG+ P Sbjct: 207 LKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPP 266 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 F A +F+ + RA+ + +I PE K+ + LL D +R+ Sbjct: 267 FRASNHLELFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRI 314
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 72.8 bits (177), Expect = 9e-13 Identities = 47/132 (35%), Positives = 69/132 (52%), Gaps = 6/132 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVITYILLCGSR 204 +KL DFG +F + E L+ GS Y APEV + Y + D+WS+GV+ Y+L+CGS Sbjct: 163 IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSL 222 Query: 205 PFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + + VL P F +S + + ++R+L D +R+T AQ H Sbjct: 223 PFDGPNLPTLRQRVLEGRFRIPFF-------MSQDCESLIRRMLVVDPARRITIAQIRQH 275 Query: 376 PWLRDE-CCPVP 408 W+R E C P P Sbjct: 276 RWMRAEPCLPGP 287
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1) (Ribosomal| protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/149 (32%), Positives = 77/149 (51%), Gaps = 7/149 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+GV+ Y +L G Sbjct: 570 IRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCT 629 Query: 205 PFW---ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + T I + + + W +IS AKD V ++L+ D +R+TA Q L H Sbjct: 630 PFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQVLQH 689 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRST 456 PW+ +D L+ +LVK + +T Sbjct: 690 PWITQKDSLPQSQLNYQDVQLVKGAMAAT 718 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 5/121 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ Sbjct: 210 NILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVL 269 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L GS PF + +L+A P F +S EA+ ++ L ++ R Sbjct: 270 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF-------LSAEAQSLLRALFKRNPANR 322 Query: 349 M 351 + Sbjct: 323 L 323
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/149 (31%), Positives = 75/149 (50%), Gaps = 7/149 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+G++ Y +L G Sbjct: 542 LRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYT 601 Query: 205 PFW---ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + T I + W ++S AKD V ++L+ D +R+TA Q L H Sbjct: 602 PFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 661 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRST 456 PW+ +D+ L +LVK + +T Sbjct: 662 PWITQKDKLPQSQLSHQDLQLVKGAMAAT 690 Score = 41.6 bits (96), Expect = 0.002 Identities = 39/135 (28%), Positives = 68/135 (50%), Gaps = 19/135 (14%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R ++ AD WS GV+ Sbjct: 192 NILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVL 251 Query: 178 -------TYILLCGSR---PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLL 327 T L+ ++ P + TE+ +S+LRA + + P+ + +KR + Sbjct: 252 MGKDRKETMTLILKAKLGMPQFLSTEA---QSLLRALFKRNPANRLGSGPDGAEEIKRHI 308 Query: 328 -------NKDYRKRM 351 NK YR+ + Sbjct: 309 FYSTIDWNKLYRREI 323
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/149 (33%), Positives = 72/149 (48%), Gaps = 7/149 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R D L +A +VAPEVL R Y D+WS+G++ Y +L G Sbjct: 551 IRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYT 610 Query: 205 PF---WARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T I + W ++S AKD V R+L+ D KR+TA Q L H Sbjct: 611 PFANGLGDTPEEILARIGSGKFTLRGGNWNTVSAAAKDLVSRMLHVDPHKRLTAKQVLQH 670 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRST 456 W+ RD L+ LVK + +T Sbjct: 671 EWITKRDALPQSQLNRQDVHLVKGAMAAT 699 Score = 58.9 bits (141), Expect = 1e-08 Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 5/192 (2%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ Sbjct: 192 NILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVL 251 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L GS PF + +L+A P F +S EA+ ++ L ++ R Sbjct: 252 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF-------LSNEAQSLLRALFKRNPTNR 304 Query: 349 MTAAQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRT 528 + +A + R P + KL + + S PFK A +A D+ Y T Sbjct: 305 LGSAMEGAEEIKRQ---PFFSTIDWNKLFRREM-SPPFKPAVTQA-------DDTYYFDT 353 Query: 529 QYNLLQPSSQDG 564 ++ P G Sbjct: 354 EFTSRTPKDSPG 365
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha| 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/151 (33%), Positives = 74/151 (49%), Gaps = 7/151 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+G++ Y +L G Sbjct: 550 IRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFT 609 Query: 205 PFWAR---TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T I + W SIS AKD V ++L+ D ++R+TA Q L H Sbjct: 610 PFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKH 669 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRSTPF 462 PW+ R+ L LVK + +T F Sbjct: 670 PWIVNREYLSQNQLSRQDVHLVKGAMAATYF 700 Score = 55.8 bits (133), Expect = 1e-07 Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 5/123 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRSYSTE-ADMWSVGVI 177 ++L E +K+ DFGLS + D+R G+ Y+APEV++R T+ AD WS GV+ Sbjct: 189 NILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVL 248 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L GS PF + +L+A P F +S EA+ ++ L ++ R Sbjct: 249 MFEMLTGSLPFQGKDRKETMALILKAKLGMPQF-------LSAEAQSLLRALFKRNPCNR 301 Query: 349 MTA 357 + A Sbjct: 302 LGA 304
>CSK2A_SPOFR (O76484) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 353 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++H+H ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 163 MIDHDHRKLRLIDWGLAEFYHPGQDYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 Query: 181 YILLCGSRPFWARTES--------------GIFRSV----LRADPNFDD-------SPWA 285 ++ PF+ ++ +F + + DP F+D W Sbjct: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELFEYLDKYHIELDPRFNDILGRHSRKRWE 282 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 +SPEA DF+ RLL D+ +R TA +A+ HP+ Sbjct: 283 RFVHSENQHLVSPEALDFLDRLLRYDHYERYTAREAMDHPY 323
>RCK2_YEAST (P38623) Serine/threonine-protein kinase RCK2 (EC 2.7.11.1) (CAM| kinase-like protein kinase CLK1) Length = 610 Score = 72.4 bits (176), Expect = 1e-12 Identities = 45/126 (35%), Positives = 61/126 (48%), Gaps = 2/126 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFGLS I + G+ Y APEV+ YS + DMW +G + Y +LCG P Sbjct: 361 VKLADFGLSKQIF-SKNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCVLYTMLCGFPP 419 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F+ + + R + F W IS AK+ V +LL + KR Q L PWL Sbjct: 420 FYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVSKLLELEPSKRYDIDQFLDDPWLN 479 Query: 388 D-ECCP 402 +C P Sbjct: 480 TFDCLP 485
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 72.0 bits (175), Expect = 2e-12 Identities = 45/135 (33%), Positives = 72/135 (53%), Gaps = 8/135 (5%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGL-SDFIRPDERLN---DIVGSAYYVAPEVLHRS---YSTEADMW 162 ++L ++ +KL DFGL S F R D L D GS Y+APEVL+ Y+ D+W Sbjct: 147 NILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYADRTDIW 206 Query: 163 SVGVITYILLCGSRPFWART-ESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDY 339 S+G++ ++LL G P+ + E+ F + D N + PW+ I + ++++L D Sbjct: 207 SIGILLFVLLTGQTPWELPSLENEDFVFFIENDGNLNWGPWSKIEFTHLNLLRKILQPDP 266 Query: 340 RKRMTAAQALSHPWL 384 KR+T HPW+ Sbjct: 267 NKRVTLKALKLHPWV 281
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 72.0 bits (175), Expect = 2e-12 Identities = 45/133 (33%), Positives = 74/133 (55%), Gaps = 5/133 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSV 168 ++L EH +K+ DFGLS D R D L+ G+ YVAPEV+ R+ +AD+WS Sbjct: 139 NLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRNGYDGFKADVWSC 198 Query: 169 GVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 GVI ++LL G PF +++ + +A+ F + W ++P AK +KR+L+ + R Sbjct: 199 GVILFVLLAGYLPFRDSNLMELYKKIGKAEVKFPN--W--LAPGAKRLLKRILDPNPNTR 254 Query: 349 MTAAQALSHPWLR 387 ++ + + W R Sbjct: 255 VSTEKIMKSSWFR 267
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 72.0 bits (175), Expect = 2e-12 Identities = 47/149 (31%), Positives = 75/149 (50%), Gaps = 7/149 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+G++ Y +L G Sbjct: 553 LRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYT 612 Query: 205 PFW---ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + T I + W ++S AKD V ++L+ D +R+TA Q L H Sbjct: 613 PFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 672 Query: 376 PWL--RDECCPVPLDMLVFKLVKAYLRST 456 PW+ +D+ L +LVK + +T Sbjct: 673 PWVTQKDKLPQSQLSHQDLQLVKGAMAAT 701 Score = 57.0 bits (136), Expect = 5e-08 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 5/121 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R +S AD WS GV+ Sbjct: 192 NILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVL 251 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L GS PF + +L+A P F +S EA+ ++ L ++ R Sbjct: 252 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF-------LSTEAQSLLRALFKRNPANR 304 Query: 349 M 351 + Sbjct: 305 L 305
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 71.6 bits (174), Expect = 2e-12 Identities = 41/120 (34%), Positives = 65/120 (54%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG S P R + G+ Y+ PE++ R+Y + D+W +GV+ Y LL G P Sbjct: 180 VKIADFGWSVHT-PSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPP 238 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + + S +R +L+ D F S+ A+D + RLL +R+ AQ L HPW++ Sbjct: 239 FESASHSETYRRILKVDVRFP----LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQ 294
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 71.6 bits (174), Expect = 2e-12 Identities = 40/121 (33%), Positives = 66/121 (54%), Gaps = 1/121 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG S P R + G+ Y+ PE++ + Y+ D+W +GV+ Y LL G P Sbjct: 153 VKISDFGWSVHT-PSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPP 211 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + T S +R + + D F +S+ A+D + +LL +R++ AQ L HPW+R Sbjct: 212 FESSTSSETYRRIRQVDFKFP----SSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVR 267 Query: 388 D 390 + Sbjct: 268 E 268
>CSK2A_NEUCR (Q8TG13) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 336 Score = 71.6 bits (174), Expect = 2e-12 Identities = 47/168 (27%), Positives = 80/168 (47%), Gaps = 39/168 (23%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++HE+ ++LID+GL++F P N V S Y+ PE+L + Y DMWS+G + Sbjct: 156 MIDHENRKLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMF 215 Query: 181 YILLCGSRPFWARTESG------------------IFRSVLRADPNFDD-------SPWA 285 ++ PF+ + + + + D +DD PW Sbjct: 216 ASMIFRKEPFFHGQSNSDQLVKIAKVLGTDELFDYLDKYEIELDAQYDDILGRFQRKPWH 275 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW---LRDE 393 S +S EA DF+ +LL D+ +R+TA +A++HP+ +RDE Sbjct: 276 SFINAENQRFVSNEAIDFLDKLLRYDHNERLTAKEAMAHPYFAPVRDE 323
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 71.2 bits (173), Expect = 3e-12 Identities = 38/129 (29%), Positives = 68/129 (52%), Gaps = 2/129 (1%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYST--EADMWSVGVI 177 +++ + S +K+IDFGLS+ ++L+ GS Y+ APE+L + T E D+WS GV+ Sbjct: 274 NIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVV 333 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 ++L+CG PF S + + + + +S E + ++L D ++R T Sbjct: 334 LFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQ----HLSIEVISLLSKMLVVDPKRRATL 389 Query: 358 AQALSHPWL 384 Q + H W+ Sbjct: 390 KQVVEHHWM 398
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 71.2 bits (173), Expect = 3e-12 Identities = 38/120 (31%), Positives = 68/120 (56%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG S P R + G+ Y+ PE++ R ++ + D+W +GV+ Y LL G+ P Sbjct: 214 LKIADFGWSVHA-PSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPP 272 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + + + +R +++ D F AS+ A+D + +LL + +R+ AQ +HPW+R Sbjct: 273 FESASHNETYRRIVKVDLKFP----ASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVR 328
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 71.2 bits (173), Expect = 3e-12 Identities = 44/124 (35%), Positives = 66/124 (53%), Gaps = 5/124 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVITYILLCGSR 204 +KL DFG +F +P E L+ GS Y APEV + Y + D+WS+GV+ Y+L+CGS Sbjct: 163 IKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSL 222 Query: 205 PFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + + VL P F +S + + ++R+L D KR+T AQ H Sbjct: 223 PFDGPNLPTLRQRVLEGRFRIPFF-------MSQDCETLIRRMLVVDPAKRITIAQIRQH 275 Query: 376 PWLR 387 W++ Sbjct: 276 RWMQ 279
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 71.2 bits (173), Expect = 3e-12 Identities = 49/138 (35%), Positives = 72/138 (52%), Gaps = 5/138 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEA-DMWSV 168 +VL +K+ DFGLS R D L+ GS YVAPEVL +R Y A D+WS Sbjct: 148 NVLLDAKGHIKITDFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLANRGYDGAASDIWSC 207 Query: 169 GVITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 GVI Y++L G PF R + +++ + + DP W +SP A+ +KR+L+ + R Sbjct: 208 GVILYVILTGCLPFDDRNLAVLYQKICKGDPPI--PRW--LSPGARTMIKRMLDPNPVTR 263 Query: 349 MTAAQALSHPWLRDECCP 402 +T + W + E P Sbjct: 264 ITVVGIKASEWFKLEYIP 281
>KCC2_SCHPO (O42844) Calcium/calmodulin-dependent protein kinase type II (EC| 2.7.11.17) (CAM kinase II) Length = 504 Score = 71.2 bits (173), Expect = 3e-12 Identities = 38/120 (31%), Positives = 58/120 (48%), Gaps = 1/120 (0%) Frame = +1 Query: 37 LIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRPFW 213 + DFG S + + G+ Y APE+++ YS DMW++G + + +LCG PF+ Sbjct: 236 IADFGFSKVVWNSKTATPC-GTVGYAAPEIVNDELYSKNVDMWAMGCVLHTMLCGFPPFF 294 Query: 214 ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLRDE 393 + V+ + F W IS AKD + LL D R+R Q HPW++ E Sbjct: 295 DENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPRERYDIHQFFQHPWIKGE 354
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 71.2 bits (173), Expect = 3e-12 Identities = 41/120 (34%), Positives = 70/120 (58%), Gaps = 4/120 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSTEADMWSVG 171 ++L +E +++ DFG + + PD R N VG+A YV+PE+L +S +D+W++G Sbjct: 213 NILLNEDMHIQITDFGTAKVLSPDSKQARANSFVGTAQYVSPELLTEKSACKSSDLWALG 272 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 I Y L+ G PF A E IF+ +++ + +F + P+A+D V++LL D KR+ Sbjct: 273 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE----KFFPKARDLVEKLLVLDATKRL 328
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 70.9 bits (172), Expect = 3e-12 Identities = 37/122 (30%), Positives = 66/122 (54%), Gaps = 1/122 (0%) Frame = +1 Query: 22 HSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCG 198 ++ +KL DFG S + + G+ Y++PE++ R Y+ + D+W++GV+TY LL G Sbjct: 243 NNTIKLTDFGWSVITPKGSKRKTLCGTVDYLSPELIRSREYNEKVDVWALGVLTYELLVG 302 Query: 199 SRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 S PF ++ ++ +L+ + F D + EA+ + RLL D R+ + HP Sbjct: 303 SPPFEEESKELTYKRILKRNLIFPD----HVDTEARHLISRLLEYDPGDRIPLKEVKKHP 358 Query: 379 WL 384 W+ Sbjct: 359 WI 360
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 70.5 bits (171), Expect = 4e-12 Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 5/124 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVL---HRSYSTEADMWSVGVITYILLCG 198 +K+ DFGL+ + + ER I G+ Y+APEVL H +S E D+WS+GV+ Y LL G Sbjct: 218 LKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIG 277 Query: 199 SRPFWARTESGIFRSVLRADPNFD-DSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF AR + I+ + D +F D P IS E K ++ +L+ D +R + + + + Sbjct: 278 KPPFQARDVNTIYERIKCRDFSFPRDKP---ISDEGKILIRDILSLDPIERPSLTEIMDY 334 Query: 376 PWLR 387 W R Sbjct: 335 VWFR 338
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 70.5 bits (171), Expect = 4e-12 Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 15/183 (8%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYST--EADMWSVGVITYILLCGSR 204 +K+IDFGLS+ ++L+ GS Y+ APE+L T E D+WS G++ Y+L+CG Sbjct: 262 IKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKV 321 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF S + + + ++ + +S E + R++ D +R T + HPW+ Sbjct: 322 PFDDENSSILHEKIKKGKVDYP----SHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWM 377 Query: 385 R---DECCP------VPL--DMLVFKLVKAYLRSTPFK--RAALKALSRAITEDELIYTR 525 D P VPL +M+ +++K R ++L R +TE E I Sbjct: 378 NRGYDFKAPSYVPNRVPLTPEMIDSQVLKEMYRLEFIDDIEDTRRSLIRLVTEKEYIQLS 437 Query: 526 TQY 534 +Y Sbjct: 438 QEY 440
>SPEG_MOUSE (Q62407) Striated muscle-specific serine/threonine protein kinase (EC| 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Length = 3262 Score = 70.5 bits (171), Expect = 4e-12 Identities = 38/122 (31%), Positives = 69/122 (56%), Gaps = 1/122 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +++ DFG + + P E G+ +VAPE++++S S D+W VGV+ ++ L G P Sbjct: 1742 VRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP 1801 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + F+++ + S+S EA+ F+ ++L +D R R TA + L HPW + Sbjct: 1802 FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWFK 1860 Query: 388 DE 393 E Sbjct: 1861 TE 1862 Score = 52.4 bits (124), Expect = 1e-06 Identities = 38/131 (29%), Positives = 62/131 (47%), Gaps = 11/131 (8%) Frame = +1 Query: 31 MKLIDFGLSDFIRPD--ERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGS 201 +K++DFG + P + L G+ ++APE++ + D+W GV+TYI+L G Sbjct: 3094 LKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGY 3153 Query: 202 RPFW--------ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 PF+ AR G F + PN S A F++++L+ R + Sbjct: 3154 SPFYEPDPQETEARIVGGRF-DAFQLYPN--------TSQSATLFLRKVLSVHPWSRPSL 3204 Query: 358 AQALSHPWLRD 390 L+HPWL+D Sbjct: 3205 QDCLAHPWLQD 3215
>SPEG_RAT (Q63638) Striated muscle-specific serine/threonine protein kinase (EC| 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Length = 3259 Score = 70.5 bits (171), Expect = 4e-12 Identities = 38/122 (31%), Positives = 69/122 (56%), Gaps = 1/122 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +++ DFG + + P E G+ +VAPE++++S S D+W VGV+ ++ L G P Sbjct: 1742 VRICDFGNAQELTPGEPQYCQFGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP 1801 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + F+++ + S+S EA+ F+ ++L +D R R TA + L HPW + Sbjct: 1802 FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWFK 1860 Query: 388 DE 393 E Sbjct: 1861 TE 1862 Score = 52.8 bits (125), Expect = 1e-06 Identities = 38/131 (29%), Positives = 62/131 (47%), Gaps = 11/131 (8%) Frame = +1 Query: 31 MKLIDFGLSDFIRPD--ERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGS 201 +K++DFG + P + L G+ ++APE++ + D+W GV+TYI+L G Sbjct: 3091 LKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVRGDPIGSATDIWGAGVLTYIMLSGY 3150 Query: 202 RPFW--------ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 PF+ AR G F + PN S A F++++L+ R + Sbjct: 3151 SPFYEPDPQETEARIVGGRF-DAFQLYPN--------TSQSATLFLRKVLSVHPWSRPSL 3201 Query: 358 AQALSHPWLRD 390 L+HPWL+D Sbjct: 3202 QDCLAHPWLQD 3212
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 70.1 bits (170), Expect = 6e-12 Identities = 44/128 (34%), Positives = 66/128 (51%), Gaps = 4/128 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS---YSTEADMWSVG 171 +++ E + +K+ DFGL+ + DE R I G+ Y+APE+L S +S E D+WS G Sbjct: 168 NIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAG 227 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 V+ Y LL G PF + I+R + +F + IS EAKD + LL D R Sbjct: 228 VVMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSN--VDISAEAKDLISSLLTHDPSIRP 285 Query: 352 TAAQALSH 375 + + H Sbjct: 286 SIDDIVDH 293
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 70.1 bits (170), Expect = 6e-12 Identities = 42/123 (34%), Positives = 66/123 (53%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSTE-ADMWSVGVITYILLCGSRP 207 +KL DFG S P R + G+ Y+ PE++ TE D+WS+GV+TY L G+ P Sbjct: 226 IKLSDFGWSVHA-PSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPP 284 Query: 208 FWART-ESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 F + S ++ + + D P+F + P+A+D + RLL + KRM+ Q + H Sbjct: 285 FEDMSGHSATYKRIAKVDLKIPSF-------VPPDARDLISRLLQHNPEKRMSLEQVMRH 337 Query: 376 PWL 384 PW+ Sbjct: 338 PWI 340
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 70.1 bits (170), Expect = 6e-12 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+GV+ Y +L G Sbjct: 557 IRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYT 616 Query: 205 PFWAR---TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T I + + W S+S AKD V ++L+ D +R+TAA L H Sbjct: 617 PFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRH 676 Query: 376 PWL 384 PW+ Sbjct: 677 PWI 679 Score = 59.3 bits (142), Expect = 1e-08 Identities = 39/123 (31%), Positives = 65/123 (52%), Gaps = 5/123 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRSYSTE-ADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R T+ AD WS GV+ Sbjct: 198 NILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L G+ PF + +L+A P F +SPEA+ ++ L ++ R Sbjct: 258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF-------LSPEAQSLLRMLFKRNPANR 310 Query: 349 MTA 357 + A Sbjct: 311 LGA 313
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 70.1 bits (170), Expect = 6e-12 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERL-NDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +++ DFG + +R + L +A +VAPEVL R Y D+WS+GV+ Y +L G Sbjct: 557 IRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYT 616 Query: 205 PFWAR---TESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T I + + W S+S AKD V ++L+ D +R+TAA L H Sbjct: 617 PFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRH 676 Query: 376 PWL 384 PW+ Sbjct: 677 PWI 679 Score = 59.3 bits (142), Expect = 1e-08 Identities = 39/123 (31%), Positives = 65/123 (52%), Gaps = 5/123 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPDERLNDIVGSAYYVAPEVLHRSYSTE-ADMWSVGVI 177 ++L E +KL DFGLS + I +++ G+ Y+APEV++R T+ AD WS GV+ Sbjct: 198 NILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257 Query: 178 TYILLCGSRPFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 + +L G+ PF + +L+A P F +SPEA+ ++ L ++ R Sbjct: 258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF-------LSPEAQSLLRMLFKRNPANR 310 Query: 349 MTA 357 + A Sbjct: 311 LGA 313
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 70.1 bits (170), Expect = 6e-12 Identities = 42/121 (34%), Positives = 60/121 (49%), Gaps = 2/121 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVITYILLCGSR 204 +K+ DFGLS+ +R L GS Y APEV+ E D+WS GVI Y LLCG+ Sbjct: 157 IKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTL 216 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF +F+ + + +S EA+D + R+L D KR+T + H W Sbjct: 217 PFDDENIPNLFKKIKGGIYTLP----SHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWF 272 Query: 385 R 387 + Sbjct: 273 Q 273
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 69.7 bits (169), Expect = 8e-12 Identities = 61/200 (30%), Positives = 90/200 (45%), Gaps = 4/200 (2%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVI 177 +VL H K+ DFGLS+ + E L GS Y APEV+ R Y+ E D+WS GVI Sbjct: 146 NVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI 205 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 Y LLCG+ PF +F+ + D F + ++P +K +L D KR T Sbjct: 206 LYALLCGTLPFDDDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHMLQVDPMKRATI 261 Query: 358 AQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAI--TEDELIYTRTQ 531 H W + + L +F +Y ST ALK + +E+E++ Sbjct: 262 KDIREHEWFKQD-----LPKYLFPEDPSY-SSTMIDDEALKEVCEKFECSEEEVLSCLYN 315 Query: 532 YNLLQPSSQDGRICIENFRM 591 N P + + I+N R+ Sbjct: 316 RNHQDPLAVAYHLIIDNRRI 335
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 69.7 bits (169), Expect = 8e-12 Identities = 61/200 (30%), Positives = 90/200 (45%), Gaps = 4/200 (2%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVI 177 +VL H K+ DFGLS+ + E L GS Y APEV+ R Y+ E D+WS GVI Sbjct: 146 NVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI 205 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 Y LLCG+ PF +F+ + D F + ++P +K +L D KR T Sbjct: 206 LYALLCGTLPFDDDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHMLQVDPMKRATI 261 Query: 358 AQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAI--TEDELIYTRTQ 531 H W + + L +F +Y ST ALK + +E+E++ Sbjct: 262 KDIREHEWFKQD-----LPKYLFPEDPSY-SSTMIDDEALKEVCEKFECSEEEVLSCLYN 315 Query: 532 YNLLQPSSQDGRICIENFRM 591 N P + + I+N R+ Sbjct: 316 RNHQDPLAVAYHLIIDNRRI 335
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 69.7 bits (169), Expect = 8e-12 Identities = 40/120 (33%), Positives = 70/120 (58%), Gaps = 4/120 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSTEADMWSVG 171 ++L +E +++ DFG + + P+ R N VG+A YV+PE+L +S +D+W++G Sbjct: 210 NILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALG 269 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 I Y L+ G PF A E IF+ +++ + +F + P+A+D V++LL D KR+ Sbjct: 270 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE----KFFPKARDLVEKLLVLDATKRL 325
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 69.7 bits (169), Expect = 8e-12 Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 1/128 (0%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVIT 180 ++L H + +K+ DFG S P R + + G+ Y+ PE++ R Y D+WS+G++ Sbjct: 227 NILLHFNDTIKISDFGWSVHA-PSNRRSTLCGTMDYLPPEIVQSRPYDKNVDVWSLGILM 285 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 Y LCG+ PF E G ++ R D +S +A D +KR+L D KR Sbjct: 286 YEFLCGAPPF---EEPGGAQATYRRIVKLDLRIPPYVSADAADLIKRMLTLDPAKRFKLK 342 Query: 361 QALSHPWL 384 HPW+ Sbjct: 343 DMHKHPWI 350
>TRIB2_PONPY (Q5R669) Tribbles homolog 2 (TRB-2)| Length = 343 Score = 69.7 bits (169), Expect = 8e-12 Identities = 37/106 (34%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHRSYSTE---ADMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ S S AD+WS+GV+ Y +L G PF S +F Sbjct: 206 DDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSK 265 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + R N ++ +SP+AK ++ +L ++ +R+T+ + L HPW Sbjct: 266 IRRGQFNIPET----LSPKAKCLIRSILRREPSERLTSQEILDHPW 307
>TRIB2_MOUSE (Q8K4K3) Tribbles homolog 2 (TRB-2)| Length = 343 Score = 69.7 bits (169), Expect = 8e-12 Identities = 37/106 (34%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHRSYSTE---ADMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ S S AD+WS+GV+ Y +L G PF S +F Sbjct: 206 DDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSK 265 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + R N ++ +SP+AK ++ +L ++ +R+T+ + L HPW Sbjct: 266 IRRGQFNIPET----LSPKAKCLIRSILRREPSERLTSQEILDHPW 307
>TRIB2_HUMAN (Q92519) Tribbles homolog 2 (TRB-2)| Length = 343 Score = 69.7 bits (169), Expect = 8e-12 Identities = 37/106 (34%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHRSYSTE---ADMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ S S AD+WS+GV+ Y +L G PF S +F Sbjct: 206 DDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSK 265 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + R N ++ +SP+AK ++ +L ++ +R+T+ + L HPW Sbjct: 266 IRRGQFNIPET----LSPKAKCLIRSILRREPSERLTSQEILDHPW 307
>TRIB2_CANFA (Q28283) Tribbles homolog 2 (TRB-2)| Length = 343 Score = 69.7 bits (169), Expect = 8e-12 Identities = 37/106 (34%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHRSYSTE---ADMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ S S AD+WS+GV+ Y +L G PF S +F Sbjct: 206 DDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSK 265 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + R N ++ +SP+AK ++ +L ++ +R+T+ + L HPW Sbjct: 266 IRRGQFNIPET----LSPKAKCLIRSILRREPSERLTSQEILDHPW 307
>TRIB2_BOVIN (Q5GLH2) Tribbles homolog 2 (TRB-2)| Length = 343 Score = 69.7 bits (169), Expect = 8e-12 Identities = 38/106 (35%), Positives = 63/106 (59%), Gaps = 3/106 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHR--SYSTEA-DMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ SYS +A D+WS+GV+ Y +L G PF S +F Sbjct: 206 DDSLSDKHGCPAYVSPEILNTNGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSK 265 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + R N ++ +SP+AK ++ +L ++ +R+T+ + L HPW Sbjct: 266 IRRGQFNIPET----LSPKAKCLIRSILRREPSERLTSQEILDHPW 307
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 69.7 bits (169), Expect = 8e-12 Identities = 40/120 (33%), Positives = 70/120 (58%), Gaps = 4/120 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDE---RLNDIVGSAYYVAPEVL-HRSYSTEADMWSVG 171 ++L +E +++ DFG + + P+ R N VG+A YV+PE+L +S +D+W++G Sbjct: 213 NILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALG 272 Query: 172 VITYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 I Y L+ G PF A E IF+ +++ + +F + P+A+D V++LL D KR+ Sbjct: 273 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYHFPE----KFFPKARDLVEKLLVLDATKRL 328
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 69.7 bits (169), Expect = 8e-12 Identities = 61/200 (30%), Positives = 90/200 (45%), Gaps = 4/200 (2%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVI 177 +VL H K+ DFGLS+ + E L GS Y APEV+ R Y+ E D+WS GVI Sbjct: 144 NVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI 203 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 Y LLCG+ PF +F+ + D F + ++P +K +L D KR T Sbjct: 204 LYALLCGTLPFDDDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHMLQVDPMKRATI 259 Query: 358 AQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAI--TEDELIYTRTQ 531 H W + + L +F +Y ST ALK + +E+E++ Sbjct: 260 KDIREHEWFKQD-----LPKYLFPEDPSY-SSTMIDDEALKEVCEKFECSEEEVLSCLYN 313 Query: 532 YNLLQPSSQDGRICIENFRM 591 N P + + I+N R+ Sbjct: 314 RNHQDPLAVAYHLIIDNRRI 333
>ATG1_ASHGO (Q75CH3) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 972 Score = 69.3 bits (168), Expect = 1e-11 Identities = 36/129 (27%), Positives = 66/129 (51%), Gaps = 1/129 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG + F+ + GS Y+APE+L ++ Y+ +AD+WSVG + Y + CG P Sbjct: 201 LKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLYEMCCGKPP 260 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F A +F+ + +A+ A++ D + LL + KRM + S+ + Sbjct: 261 FKASNHLELFQKIKKANDVIQFPKHAALESAMVDLICGLLTFEPAKRMGFTEFFSNGLVN 320 Query: 388 DECCPVPLD 414 ++ P ++ Sbjct: 321 EDLSPYEVE 329
>CSK22_CHICK (P21869) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 69.3 bits (168), Expect = 1e-11 Identities = 42/161 (26%), Positives = 78/161 (48%), Gaps = 36/161 (22%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL--HRSYSTEADMWSVGVIT 180 +++H+ ++LID+GL++F P + N V S Y+ PE+L ++ Y DMWS+G + Sbjct: 164 MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 223 Query: 181 YILLCGSRPFWARTES-----------------GIFRSV-LRADPNFDD-------SPWA 285 ++ PF+ ++ G + + DP+F+D W Sbjct: 224 ASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIELDPHFNDILGQHSRKRWE 283 Query: 286 S---------ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + +SPE D + +LL D+++R+TA +A+ HP+ Sbjct: 284 NFIHSENRHLVSPEVLDLLDKLLRYDHQQRLTAKEAMEHPY 324
>SPEG_BRARE (Q696W0) Striated muscle preferentially expressed protein kinase (EC| 2.7.11.1) Length = 2995 Score = 69.3 bits (168), Expect = 1e-11 Identities = 37/120 (30%), Positives = 67/120 (55%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +++ DFG + ++P+E L G ++APE++++S S D+W VGVITY+ L G P Sbjct: 1388 IRICDFGNALKVKPNEELYCKYGIPEFIAPEIVNQSPISKSTDIWPVGVITYLCLTGVSP 1447 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + F++S + + EAK F+ ++L + + R A + L HPW + Sbjct: 1448 FAGENDRDTLLNIRNYNVAFEESMFKDLCREAKGFIIKVLVSN-KLRPDATECLLHPWFK 1506 Score = 61.2 bits (147), Expect = 3e-09 Identities = 42/128 (32%), Positives = 67/128 (52%), Gaps = 8/128 (6%) Frame = +1 Query: 31 MKLIDFGLSDFIRPD--ERLNDIVGSAYYVAPEVLHRSY-STEADMWSVGVITYILLCGS 201 +K+IDFG + P ++ + +G+ Y+APE+L AD+WS+GV++YI+L G Sbjct: 2815 IKIIDFGSAQRFNPLSLQQCSRYLGTLEYMAPEMLKGDLVGPPADIWSLGVLSYIMLSGR 2874 Query: 202 RPFWAR----TESGIFRSVLRADPNFDDSP-WASISPEAKDFVKRLLNKDYRKRMTAAQA 366 PF + TE+ I + FD + + +S A F+K++LN R T Sbjct: 2875 HPFEDKDPQLTEAKIH------EAKFDSTKLYPKVSQSASTFLKKILNSYPWCRPTIKDC 2928 Query: 367 LSHPWLRD 390 L+H WL D Sbjct: 2929 LNHSWLHD 2936
>SPEG_HUMAN (Q15772) Striated muscle preferentially expressed protein kinase (EC| 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Length = 3223 Score = 69.3 bits (168), Expect = 1e-11 Identities = 37/122 (30%), Positives = 69/122 (56%), Gaps = 1/122 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSRP 207 +++ DFG + + P E G+ +VAPE++++S S D+W VGV+ ++ L G P Sbjct: 1737 VRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP 1796 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + ++ + F+++ + S+S EA+ F+ ++L +D R R TA + L HPW + Sbjct: 1797 FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWFK 1855 Query: 388 DE 393 + Sbjct: 1856 TQ 1857 Score = 43.1 bits (100), Expect = 8e-04 Identities = 36/134 (26%), Positives = 56/134 (41%), Gaps = 11/134 (8%) Frame = +1 Query: 31 MKLIDFGLSDFIRPD--ERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGS 201 +K++DFG + P L G+ ++APE++ + D+W GV+TYI+L G Sbjct: 3099 LKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGR 3158 Query: 202 RPFW--------ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 PF+ AR G F + PN S A F++++L+ Sbjct: 3159 SPFYEPDPQETEARIVGGRF-DAFQLYPN--------TSQSATLFLRKVLS--------- 3200 Query: 358 AQALSHPWLRDECC 399 HPW R C Sbjct: 3201 ----VHPWSRPSSC 3210
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 69.3 bits (168), Expect = 1e-11 Identities = 41/130 (31%), Positives = 63/130 (48%), Gaps = 4/130 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + F+ + GS Y+APEV+ Y +AD+WS+G I + L G P Sbjct: 158 IKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAP 217 Query: 208 FWARTE---SGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 F A+T + PN + W SP +D + RLL ++ + R++ +HP Sbjct: 218 FVAQTPPQLKAYYEKTRELRPNIPE--WC--SPNLRDLLLRLLKRNAKDRISFEDFFNHP 273 Query: 379 WLRDECCPVP 408 +L P P Sbjct: 274 FLTSPLLPSP 283
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 68.9 bits (167), Expect = 1e-11 Identities = 43/132 (32%), Positives = 63/132 (47%), Gaps = 10/132 (7%) Frame = +1 Query: 25 SPMKLIDFGLSDFI--RPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLC 195 +P+K+IDFG + P E + + Y APE+L + Y D+WS+GVI Y++L Sbjct: 545 APVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLS 604 Query: 196 GSRPFWARTESG-------IFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMT 354 G PF + G I + + D W +S EAK+ V+ LL D KR+ Sbjct: 605 GQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLK 664 Query: 355 AAQALSHPWLRD 390 S WL+D Sbjct: 665 LEGLRSSSWLQD 676 Score = 63.9 bits (154), Expect = 4e-10 Identities = 45/141 (31%), Positives = 73/141 (51%), Gaps = 13/141 (9%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLS-DFIRPD-ERLNDIVGSAYYVAPEVLHRS--YSTEADMWSVG 171 +VL + L DFGLS +F+ + ER G+ Y+APE++ + D WS+G Sbjct: 166 NVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLG 225 Query: 172 VITYILLCGSRPFW----ARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDY 339 ++ + LL G+ PF T++ + R +L+ P F I P A+D ++RLL KD Sbjct: 226 ILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFP----LRIGPVAQDLLQRLLCKDP 281 Query: 340 RKRMTAA-----QALSHPWLR 387 +KR+ A + SHP+ + Sbjct: 282 KKRLGAGPQGAQEVKSHPFFQ 302
>ATG1_NEUCR (Q7RX99) Serine/threonine-protein kinase atg-1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 932 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 1/168 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG + + + GS Y+APE+L + Y +AD+WSVG + Y ++ G P Sbjct: 211 LKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVTGRPP 270 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F A + R + + + + +S E K ++ LL K+ +R++ +HP + Sbjct: 271 FKASNHVELLRKIESSGDVIKFTRESVVSQEMKGLIRALLKKNPVERISFEDLFNHPVVT 330 Query: 388 DECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQ 531 + P+P LV+ + P +R+ + + ED L+ +R Q Sbjct: 331 E---PIP------GLVEDDIPKPPRRRSLKEERPVSRAEDSLVPSRKQ 369
>AKT1_HUMAN (P31749) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT) Length = 480 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 7/193 (3%) Frame = +1 Query: 31 MKLIDFGL-SDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +K+ DFGL + I+ + G+ Y+APEVL Y D W +GV+ Y ++CG Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM-----TAAQAL 369 PF+ + +F +L + F ++ PEAK + LL KD ++R+ A + + Sbjct: 348 PFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 H + +V++ V S PFK ++E +T + P Sbjct: 404 QHRFFAG---------IVWQHVYEKKLSPPFKPQVTSETDTRYFDEE--FTAQMITITPP 452 Query: 550 SSQDGRICIENFR 588 D C+++ R Sbjct: 453 DQDDSMECVDSER 465
>ASK2_ARATH (P43292) Serine/threonine-protein kinase ASK2 (EC 2.7.11.1)| Length = 353 Score = 68.6 bits (166), Expect = 2e-11 Identities = 46/162 (28%), Positives = 74/162 (45%), Gaps = 4/162 (2%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVITYILLCGSR 204 +K+ DFG S R VG+ Y+APEVL R AD+WS GV Y++L G+ Sbjct: 139 LKICDFGYSKSSILHSRPKSTVGTPAYIAPEVLSRREYDGKHADVWSCGVTLYVMLVGAY 198 Query: 205 PFWARTESGIFRSVLR--ADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHP 378 PF + FR ++ + + IS E K + R+ + KR+T + +HP Sbjct: 199 PFEDPNDPKNFRKTIQRIMAVQYKIPDYVHISQECKHLLSRIFVTNSAKRITLKEIKNHP 258 Query: 379 WLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITE 504 W +P ++L Y R T F +++ + + + E Sbjct: 259 WYLKN---LPKELLESAQAAYYKRDTSFSLQSVEDIMKIVGE 297
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 68.2 bits (165), Expect = 2e-11 Identities = 41/123 (33%), Positives = 68/123 (55%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILLCGSR 204 +K+ DFGL+ ++ P E+ + G+ Y++PE+ RS + E+D+WS+G + Y LL G Sbjct: 150 IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRP 209 Query: 205 PFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T V+ AD P F +S EAKD + +LL ++ R++ + L H Sbjct: 210 PFDTDTVKNTLNKVVLADYEMPTF-------LSIEAKDLIHQLLRRNPADRLSLSSVLDH 262 Query: 376 PWL 384 P++ Sbjct: 263 PFM 265
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/140 (30%), Positives = 73/140 (52%), Gaps = 2/140 (1%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIR-PDERLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVI 177 ++L + +K+ DFGL+ + P E+ + G+ Y++PE+ RS + E+D+WS+G + Sbjct: 141 NILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCM 200 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 Y LL G PF T V+ AD A +S EA+D + +LL ++ R++ Sbjct: 201 FYTLLIGRPPFDTDTVKNTLNKVVLADYEMP----AFLSREAQDLIHQLLRRNPADRLSL 256 Query: 358 AQALSHPWLRDECCPVPLDM 417 + L HP++ P D+ Sbjct: 257 SSVLDHPFMSRNPSPKSKDV 276
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 67.8 bits (164), Expect = 3e-11 Identities = 60/200 (30%), Positives = 89/200 (44%), Gaps = 4/200 (2%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVI 177 +VL H K+ DFGLS+ + E L GS Y APEV+ R Y+ E D+WS GVI Sbjct: 144 NVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI 203 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTA 357 Y LLCG+ PF +F+ + D F + ++P +K +L D KR Sbjct: 204 LYALLCGTLPFDDDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHMLQVDPMKRAAI 259 Query: 358 AQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAI--TEDELIYTRTQ 531 H W + + L +F +Y ST ALK + +E+E++ Sbjct: 260 KDIREHEWFKQD-----LPKYLFPEDPSY-SSTMIDDEALKEVCEKFECSEEEVLSCLYN 313 Query: 532 YNLLQPSSQDGRICIENFRM 591 N P + + I+N R+ Sbjct: 314 RNHQDPLAVAYHLIIDNRRI 333
>AKT1_RAT (P47196) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) Length = 480 Score = 67.8 bits (164), Expect = 3e-11 Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 7/193 (3%) Frame = +1 Query: 31 MKLIDFGL-SDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +K+ DFGL + I+ + G+ Y+APEVL Y D W +GV+ Y ++CG Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM-----TAAQAL 369 PF+ + +F +L + F ++ PEAK + LL KD +R+ A + + Sbjct: 348 PFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIM 403 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 H + + +V++ V S PFK ++E +T + P Sbjct: 404 QHRFFAN---------IVWQDVYEKKLSPPFKPQVTSETDTRYFDEE--FTAQMITITPP 452 Query: 550 SSQDGRICIENFR 588 D C+++ R Sbjct: 453 DQDDSMECVDSER 465
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 67.8 bits (164), Expect = 3e-11 Identities = 40/128 (31%), Positives = 65/128 (50%), Gaps = 1/128 (0%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVIT 180 ++L + +K+ DFG S P R + G+ Y+ PE++ R + + D+WS+GV+ Sbjct: 268 NLLLGSNGELKIADFGWSVHA-PSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLC 326 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 Y L G PF T +R + + + F P+ +S EAKD V +LL + R+ Sbjct: 327 YEFLVGKPPFETDTHQETYRRISKVE--FQYPPY--VSEEAKDLVSKLLKHNPNHRLPLK 382 Query: 361 QALSHPWL 384 L HPW+ Sbjct: 383 GVLEHPWI 390
>AKT2B_XENLA (Q6IP76) RAC-beta serine/threonine-protein kinase-B (EC 2.7.11.1)| (RAC-PK-beta-B) (Protein kinase Akt-2-B) (Protein kinase B, beta-B) (PKB beta-B) Length = 485 Score = 67.8 bits (164), Expect = 3e-11 Identities = 51/191 (26%), Positives = 83/191 (43%), Gaps = 7/191 (3%) Frame = +1 Query: 31 MKLIDFGL-SDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +K+ DFGL + I + G+ Y+APEVL Y D W +GV+ Y ++CG Sbjct: 293 VKITDFGLCKEGITDGATMRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 352 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM-----TAAQAL 369 PF+ + +F +L + F ++SPEAK + LL KD ++R+ A + + Sbjct: 353 PFYNQDHERLFELILMEETRFP----RTLSPEAKSLLAGLLKKDPKQRLGGGPDDAQEVM 408 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 SH + + ++ V S PFK + +DE +T L P Sbjct: 409 SHGFFAS---------INWQDVTERKLSPPFKPQVTSEIDTRYFDDE--FTAQSITLTPP 457 Query: 550 SSQDGRICIEN 582 D +E+ Sbjct: 458 DRYDNLDALES 468
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 67.8 bits (164), Expect = 3e-11 Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 6/142 (4%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPD-ERLNDIVGSAYYVAPEVLHR-SYSTEADMWSVGVI 177 S+L +KL DFG + + + +VG+ Y+++PEV+ R Y E D+WS+G++ Sbjct: 492 SILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIM 551 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADP-NFDDSPWASISPEAKDFVKRLLNKDYRKRMT 354 ++ G PF+ R + P N ++ +SP + F+ R+L +D +R T Sbjct: 552 VIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAH--KVSPRLQSFLDRMLVRDPAQRAT 609 Query: 355 AAQALSHPWLRDECCP---VPL 411 AA+ L+HP+LR P VPL Sbjct: 610 AAELLAHPFLRQAGPPSLLVPL 631
>YP150_YEAST (Q12152) Putative serine/threonine-protein kinase YPL150W (EC| 2.7.11.1) Length = 901 Score = 67.8 bits (164), Expect = 3e-11 Identities = 53/178 (29%), Positives = 87/178 (48%), Gaps = 7/178 (3%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVI 177 ++L ++ KL DFG + L + G+ Y+APE++ R + D+WS+GVI Sbjct: 162 NILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVI 221 Query: 178 TYILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISP-EAKDFVKRLLNKDYRKRMT 354 Y L+ G PF E+ ++ +P +D A + P +A+D + RLL K+ +R + Sbjct: 222 LYTLITGYLPFDDDDEAKTKWKIVNEEPKYD----AKVIPDDARDLISRLLAKNPGERPS 277 Query: 355 AAQALSHPWLRDECCPVPLDMLVFKLVKAYLRSTPFK----RAALKALSRAITEDELI 516 +Q L HP+L+ V LD L + T FK R LK L ++ + + I Sbjct: 278 LSQVLRHPFLQ-PYGSVVLDQTQKILCRQRSGGTQFKSKLERRLLKRLKQSGVDTQAI 334
>AKT_MLVAT (P31748) AKT kinase transforming protein (EC 2.7.11.1)| Length = 501 Score = 67.8 bits (164), Expect = 3e-11 Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 7/193 (3%) Frame = +1 Query: 31 MKLIDFGL-SDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +K+ DFGL + I+ + G+ Y+APEVL Y D W +GV+ Y ++CG Sbjct: 309 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 368 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM-----TAAQAL 369 PF+ + +F +L + F ++ PEAK + LL KD +R+ A + + Sbjct: 369 PFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIM 424 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 H + + +V++ V S PFK ++E +T + P Sbjct: 425 QHRFFAN---------IVWQDVYEKKLSPPFKPQVTSETDTRYFDEE--FTAQMITITPP 473 Query: 550 SSQDGRICIENFR 588 D C+++ R Sbjct: 474 DQDDSMECVDSER 486
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 67.4 bits (163), Expect = 4e-11 Identities = 36/120 (30%), Positives = 67/120 (55%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG S P R + G+ Y+ PE++ R ++ D+W +GV+ Y L+ G+ P Sbjct: 219 LKIADFGWSVHA-PSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPP 277 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + + S +R +++ D F +S+ A+D + +LL + +R+ A+ +HPW+R Sbjct: 278 FESPSHSETYRRIVKVDLKFP----SSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVR 333
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 67.4 bits (163), Expect = 4e-11 Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 1/119 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +KL DFG S P+ R + G+ Y++PE++ R Y D W++GV+ + LL G+ P Sbjct: 241 IKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPP 300 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F + ++ + D ++IS +A+D + +LL D + RM HPW+ Sbjct: 301 FEEEMKDTTYKRIAALDIKMP----SNISQDAQDLILKLLKYDPKDRMRLGDVKMHPWI 355
>TRIB1_MOUSE (Q8K4K4) Tribbles homolog 1 (TRB-1)| Length = 372 Score = 67.4 bits (163), Expect = 4e-11 Identities = 39/106 (36%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHRS--YSTEA-DMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ + YS +A D+WS+GV+ Y LL G PF S +F Sbjct: 236 DDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSK 295 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 + R + +SP+A+ ++ LL ++ +R+TA Q L HPW Sbjct: 296 IRRGQFCIPEH----VSPKARCLIRSLLRREPSERLTAPQILLHPW 337
>TRIB1_HUMAN (Q96RU8) Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled| receptor induced protein 2) (GIG-2) Length = 372 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/117 (35%), Positives = 64/117 (54%), Gaps = 3/117 (2%) Frame = +1 Query: 73 DERLNDIVGSAYYVAPEVLHRS--YSTEA-DMWSVGVITYILLCGSRPFWARTESGIFRS 243 D+ L+D G YV+PE+L+ + YS +A D+WS+GV+ Y LL G PF S +F Sbjct: 236 DDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSK 295 Query: 244 VLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLRDECCPVPLD 414 + R + ISP+A+ ++ LL ++ +R+TA + L HPW P +D Sbjct: 296 IRRGQFCIPEH----ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYID 348
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 67.0 bits (162), Expect = 5e-11 Identities = 37/119 (31%), Positives = 61/119 (51%), Gaps = 1/119 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG S P R + G+ Y+ PE++ R + + D+WS+GV+ Y L G P Sbjct: 270 LKIADFGWSVHA-PSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP 328 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 F A T ++ + R + F D ++ A+D + RLL + +R + L HPW+ Sbjct: 329 FEANTYQETYKRISRVEFTFPD----FVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 383
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 67.0 bits (162), Expect = 5e-11 Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 5/124 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVITYILLCGSR 204 +KL DFG +F + E L+ GS Y APEV + Y D+WS+GV+ Y+L+CGS Sbjct: 162 IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLDIWSLGVVLYVLVCGSL 221 Query: 205 PFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF + + VL P F +S + + ++R+L D KR+T +Q H Sbjct: 222 PFDGPNLPTLRQRVLEGRFRIPYF-------MSEDCETLIRRMLVVDPTKRITISQIKQH 274 Query: 376 PWLR 387 W++ Sbjct: 275 KWMQ 278
>CDR1_SCHPO (P07334) Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein| kinase nim1) Length = 593 Score = 67.0 bits (162), Expect = 5e-11 Identities = 40/120 (33%), Positives = 64/120 (53%), Gaps = 2/120 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSY-STEADMWSVGVITYILLCGSR 204 +K+ DFG++ D L + GS +Y+APE++ H+ Y AD+WS GVI Y LL Sbjct: 143 IKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKL 202 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF + I+ + + +SIS A+D + R+L+ + R+T + SHP+L Sbjct: 203 PFGGQNTDVIYNKIRHGAYDLP----SSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFL 258
>AKT1_MOUSE (P31750) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto-oncogene) Length = 480 Score = 67.0 bits (162), Expect = 5e-11 Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 7/193 (3%) Frame = +1 Query: 31 MKLIDFGL-SDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +K+ DFGL + I+ + G+ Y+APEVL Y D W +GV+ Y ++CG Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM-----TAAQAL 369 PF+ + +F +L + F ++ PEAK + LL KD +R+ A + + Sbjct: 348 PFYNQDHEKLFELILMEEIAFP----RTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIM 403 Query: 370 SHPWLRDECCPVPLDMLVFKLVKAYLRSTPFKRAALKALSRAITEDELIYTRTQYNLLQP 549 H + + +V++ V S PFK ++E +T + P Sbjct: 404 QHRFFAN---------IVWQDVYEKKLSPPFKPQVTSETDTRYFDEE--FTAQMITITPP 452 Query: 550 SSQDGRICIENFR 588 D C+++ R Sbjct: 453 DQDDSMECVDSER 465
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 67.0 bits (162), Expect = 5e-11 Identities = 45/133 (33%), Positives = 68/133 (51%), Gaps = 5/133 (3%) Frame = +1 Query: 31 MKLIDFGLS---DFIRPDERLNDIVGSAYYVAPEVLH-RSYS-TEADMWSVGVITYILLC 195 +K+ DFGLS + ++ D L+ G+ YVAPEV+ R Y AD+WS GVI Y+LL Sbjct: 157 LKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDRGYDGAAADIWSCGVILYVLLA 216 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF +++ + ++ F W S AK + R+L+ + R+T +Q L Sbjct: 217 GFLPFEDDNIIALYKKI--SEAQFTCPSW--FSTGAKKLITRILDPNPTTRITISQILED 272 Query: 376 PWLRDECCPVPLD 414 PW + P D Sbjct: 273 PWFKKGYKPPVFD 285
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 67.0 bits (162), Expect = 5e-11 Identities = 56/211 (26%), Positives = 94/211 (44%), Gaps = 17/211 (8%) Frame = +1 Query: 4 SVLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVI 177 ++L E + +K+ DFGLS+ + + L GS Y APEV+ E D+WS GVI Sbjct: 215 NLLLDEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVI 274 Query: 178 TYILLCGSRPFWARTESGIFRSV---LRADPNFDDSPWASISPEAKDFVKRLLNKDYRKR 348 Y LLCG+ PF +FR + + P+F + P ++ + +L D KR Sbjct: 275 LYALLCGTLPFDDEHVPSLFRKIKSGVFPTPDFLERPIVNL-------LHHMLCVDPMKR 327 Query: 349 MTAAQALSHPWLRDEC-----CPVPLDMLVFKLVKAYLRSTPFKR---AALKALSRAITE 504 T ++H W + + P+ ++A T F+R A + S + + Sbjct: 328 ATIKDVIAHEWFQKDLPNYLFPPINESEASIVDIEAVREVTEFQRYHVAEEEVTSALLGD 387 Query: 505 DELIYTRTQYNLL----QPSSQDGRICIENF 585 D + YNL+ + + + ++ IE F Sbjct: 388 DPHHHLSIAYNLIVDNKRIADETAKLSIEEF 418
>NRC2_NEUCR (O42626) Serine/threonine-protein kinase nrc-2 (EC 2.7.11.1)| (Nonrepressible conidiation protein 2) Length = 623 Score = 67.0 bits (162), Expect = 5e-11 Identities = 40/109 (36%), Positives = 59/109 (54%), Gaps = 6/109 (5%) Frame = +1 Query: 79 RLNDIVGSAYYVAPEVLHRSYSTEA-DMWSVGVITYILLCGSRPFWARTESGIFRSVLRA 255 R N VG+ Y+APEV+ S T A D W++G++ Y +L G+ PF + + F ++LR Sbjct: 425 RTNSFVGTEEYIAPEVIKGSGHTSAVDWWTLGILIYEMLYGTTPFKGKNRNATFANILRE 484 Query: 256 DPNFDDSPWA-SISPEAKDFVKRLLNKDYRKRMTAAQALS----HPWLR 387 D F D A IS K +++LL KD +R+ A S HP+ R Sbjct: 485 DIPFPDHAGAPQISNLCKSLIRKLLIKDENRRLGARAGASDIKTHPFFR 533
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 67.0 bits (162), Expect = 5e-11 Identities = 39/129 (30%), Positives = 72/129 (55%), Gaps = 2/129 (1%) Frame = +1 Query: 7 VLEHEHSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPE-VLHRSY-STEADMWSVGVIT 180 +L+ ++ +K+ DFG++ P++ L GS +Y +PE V+ R Y +D+WS G++ Sbjct: 246 LLDKKNRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVL 305 Query: 181 YILLCGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAA 360 + LL G PF + I + +L+ P +++S EA+D + ++L D KR+T Sbjct: 306 FALLTGHLPF---NDDNIKKLLLKVQSGKYQMP-SNLSSEARDLISKILVIDPEKRITTQ 361 Query: 361 QALSHPWLR 387 + L HP ++ Sbjct: 362 EILKHPLIK 370
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 67.0 bits (162), Expect = 5e-11 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 5/123 (4%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVITYILLCGSR 204 +K+ DFG +F + E L GS Y APEV + D+WS+GV+ Y+L+CG+ Sbjct: 156 IKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGAL 215 Query: 205 PFWARTESGIFRSVLRAD---PNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 PF T + + VL P F +S + + ++R+L D KR+T AQ H Sbjct: 216 PFDGPTLPILRQRVLEGRFRIPYF-------MSEDCEHLIRRMLVLDPSKRLTIAQIKEH 268 Query: 376 PWL 384 W+ Sbjct: 269 KWM 271
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 67.0 bits (162), Expect = 5e-11 Identities = 37/120 (30%), Positives = 66/120 (55%), Gaps = 1/120 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG S P R + G+ Y+ PE++ R ++ D+W +GV+ Y L+ G+ P Sbjct: 217 LKIADFGWSVHA-PSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPP 275 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F + + S +R +++ D F +S+ AKD + +LL + +R+ Q +HPW+R Sbjct: 276 FESPSHSETYRRIVKVDLKFP----SSMPLGAKDLISKLLKHNPSQRLPLEQVSAHPWVR 331
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 67.0 bits (162), Expect = 5e-11 Identities = 44/121 (36%), Positives = 68/121 (56%), Gaps = 3/121 (2%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +KL DFG + + + L I G+ Y++PE++ R Y AD+WSVG I Y L G+ Sbjct: 139 IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTP 198 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWAS-ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF+A + + +L+ D W S ISP K+F++ LL KD R+R++ L HP+ Sbjct: 199 PFYATSIFQLVSLILK-----DPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPF 253 Query: 382 L 384 + Sbjct: 254 I 254
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 67.0 bits (162), Expect = 5e-11 Identities = 44/121 (36%), Positives = 68/121 (56%), Gaps = 3/121 (2%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDER-LNDIVGSAYYVAPEVLH-RSYSTEADMWSVGVITYILLCGSR 204 +KL DFG + + + L I G+ Y++PE++ R Y AD+WSVG I Y L G+ Sbjct: 139 IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTP 198 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWAS-ISPEAKDFVKRLLNKDYRKRMTAAQALSHPW 381 PF+A + + +L+ D W S ISP K+F++ LL KD R+R++ L HP+ Sbjct: 199 PFYATSIFQLVSLILK-----DPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPF 253 Query: 382 L 384 + Sbjct: 254 I 254
>ATG1_KLULA (Q6CSX2) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 831 Score = 66.6 bits (161), Expect = 6e-11 Identities = 34/108 (31%), Positives = 57/108 (52%), Gaps = 1/108 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG + F+ + GS Y+APE+L ++ Y+ +AD+WSVG + Y + CG P Sbjct: 203 LKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLYEMCCGRPP 262 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 F A +F+ + +A+ I P+ + ++ LL D RM Sbjct: 263 FKASNHLELFQKIKKANDEITVPSNCYIEPKLFNLIRGLLTFDPDSRM 310
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 66.6 bits (161), Expect = 6e-11 Identities = 44/153 (28%), Positives = 73/153 (47%), Gaps = 5/153 (3%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG + ++ + + GS Y+APEV+ + Y +AD+WS+G + Y L G P Sbjct: 154 IKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPP 213 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWLR 387 F A + + R + + S SP + + LL ++ + RM SHP+L Sbjct: 214 FQANSPQDL-RMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLE 272 Query: 388 D----ECCPVPLDMLVFKLVKAYLRSTPFKRAA 474 + CPVP+ M + + S+P R A Sbjct: 273 QGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFA 305
>PLK3_HUMAN (Q9H4B4) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 66.6 bits (161), Expect = 6e-11 Identities = 45/121 (37%), Positives = 63/121 (52%), Gaps = 2/121 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILL 192 E+ +K+ DFGL+ + P E R I G+ YVAPEVL R + EAD+WS+G + Y LL Sbjct: 195 ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLL 254 Query: 193 CGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 CGS PF E+ + R + AS+S A+ + +L R R + Q L Sbjct: 255 CGSPPF----ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILR 310 Query: 373 H 375 H Sbjct: 311 H 311
>ATG1_CANGA (Q6FL58) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 942 Score = 66.2 bits (160), Expect = 8e-11 Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 1/108 (0%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVL-HRSYSTEADMWSVGVITYILLCGSRP 207 +K+ DFG + F+ + GS Y+APE+L ++ Y+ +AD+WSVG + + + CG P Sbjct: 194 LKIADFGFARFLPSTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLFEMCCGVPP 253 Query: 208 FWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRM 351 F A +F+ + RA + + K+ + LL D KR+ Sbjct: 254 FTASNHLELFKKIKRAHDEINFPEVCEVEDGLKELICSLLTFDPAKRI 301
>CDR2_SCHPO (P87050) Mitosis inducer protein kinase cdr2 (EC 2.7.11.1)| Length = 775 Score = 66.2 bits (160), Expect = 8e-11 Identities = 53/192 (27%), Positives = 93/192 (48%), Gaps = 14/192 (7%) Frame = +1 Query: 22 HSPMKLIDFGLSDFIRPDERLNDIVGSAYYVAPE-VLHRSY-STEADMWSVGVITYILLC 195 H +K+ +FG++ +P + L GS +Y +PE ++ RSY +D+WS G+I + LL Sbjct: 144 HGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLT 203 Query: 196 GSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSH 375 G PF + I +L+ + P ++ISP+A+ + R+L+ D R+T Q H Sbjct: 204 GKLPF---DDDNIRSLLLKVCQGQFEMP-SNISPQAQHLLYRMLDVDSSTRITMEQIREH 259 Query: 376 PWLRDECCP-----------VPLDMLVFKLVKAYLRSTPFKRAALKAL-SRAITEDELIY 519 P+L P P+D L+ + + R + + L S++ ++ +Y Sbjct: 260 PFLSCFVHPNISIPIISAPIQPIDPLIVQHLSLVFRCSDDPMPLYEKLASQSPLVEKTLY 319 Query: 520 TRTQYNLLQPSS 555 T +L PSS Sbjct: 320 TLLSRHLHPPSS 331
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 66.2 bits (160), Expect = 8e-11 Identities = 38/121 (31%), Positives = 61/121 (50%), Gaps = 2/121 (1%) Frame = +1 Query: 31 MKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSY--STEADMWSVGVITYILLCGSR 204 +K+ DFGLS+++ + L+ GS Y APE++ E D+WS GVI Y +LCG+ Sbjct: 161 IKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTL 220 Query: 205 PFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALSHPWL 384 PF + +F + P+ S+ +A D + +L D KR + ++H W Sbjct: 221 PFDDQNVPTLFAKIKSGRYTV---PY-SMEKQAADLISTMLQVDPVKRADVKRIVNHSWF 276 Query: 385 R 387 R Sbjct: 277 R 277
>PLK3_RAT (Q9R011) Serine/threonine-protein kinase PLK3 (EC 2.7.11.21)| (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Fragment) Length = 615 Score = 65.9 bits (159), Expect = 1e-10 Identities = 44/121 (36%), Positives = 63/121 (52%), Gaps = 2/121 (1%) Frame = +1 Query: 19 EHSPMKLIDFGLSDFIRPDE-RLNDIVGSAYYVAPEVLHRS-YSTEADMWSVGVITYILL 192 ++ +K+ DFGL+ + P E R I G+ YVAPEVL R + EAD+WS+G + Y LL Sbjct: 164 DNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLL 223 Query: 193 CGSRPFWARTESGIFRSVLRADPNFDDSPWASISPEAKDFVKRLLNKDYRKRMTAAQALS 372 CGS PF E+ + R + AS+S A+ + +L R R + Q L Sbjct: 224 CGSPPF----ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILR 279 Query: 373 H 375 H Sbjct: 280 H 280 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 90,333,367 Number of Sequences: 219361 Number of extensions: 1752004 Number of successful extensions: 6634 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5516 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5796 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6598423128 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
