ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | rbaal29m23 |
|---|---|
| Clone Library Name | barley_pub |
>C72A1_CATRO (Q05047) Cytochrome P450 72A1 (EC 1.3.3.9) (CYPLXXII) (Secologanin| synthase) (SLS) Length = 524 Score = 191 bits (485), Expect = 2e-48 Identities = 88/189 (46%), Positives = 128/189 (67%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 E T +LLTW+ LLS +PEWQER R+EVL+ FG P+ LN LK ++M+L+E LRLY Sbjct: 335 ETTGVLLTWTTILLSKHPEWQERAREEVLQAFGKNKPEFERLNHLKYVSMILYEVLRLYP 394 Query: 535 PALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAA 356 P + + + D +GS +P G +++P ++HR+K +WG+DA EF P+RF +G+ A Sbjct: 395 PVIDLTKIVHKDTKLGSYTIPAGTQVMLPTVMLHREKSIWGEDAMEFNPMRFVDGVANAT 454 Query: 355 KVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKFG 176 K L FS GPR C+GQNF++L+AK LA++LQ+F F ++P YVHAP I T++P+FG Sbjct: 455 KNNVTYLPFSWGPRVCLGQNFALLQAKLGLAMILQRFKFDVAPSYVHAPFTILTVQPQFG 514 Query: 175 LQVFVRPLD 149 V + L+ Sbjct: 515 SHVIYKKLE 523
>CP4B1_RAT (P15129) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-isozyme| 5) (P450 L-2) Length = 510 Score = 109 bits (272), Expect = 1e-23 Identities = 69/191 (36%), Positives = 103/191 (53%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ-SPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W +Y +++YPE Q+ R+EV G Q S + L K+ +TM + E RL Sbjct: 316 HDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDSFQWDDLAKMTYLTMCMKECFRL 375 Query: 541 YSPALFMQRKTVADMT-VGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ +T V LP G I + I +HR+ VW D + F PLRF Sbjct: 376 YPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVW-PDPEVFDPLRFSPE-N 433 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 A + P + FS GPR+CIGQ F+M E K AL L +F F+L P + V L+ Sbjct: 434 AAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQLILRS 493 Query: 184 KFGLQVFVRPL 152 K G+ ++++PL Sbjct: 494 KNGIHLYLKPL 504
>CP4B1_RABIT (P15128) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-isozyme| 5) Length = 506 Score = 109 bits (272), Expect = 1e-23 Identities = 66/191 (34%), Positives = 106/191 (55%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ-SPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W +Y +++YPE Q+R R+EV + G Q S L K+ +TM + E RL Sbjct: 312 HDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRL 371 Query: 541 YSPALFMQRKTVADMT-VGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ ++ V LP G I + I +HR+ +VW D + F PLRF Sbjct: 372 YPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVW-PDPEVFDPLRFSPE-N 429 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + + P+ + FS GPR+CIGQ F+M E K AL L +F F++ P + + L+ Sbjct: 430 SSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLPIKLPQLVLRS 489 Query: 184 KFGLQVFVRPL 152 K G+ ++++PL Sbjct: 490 KNGIHLYLKPL 500
>CP4B1_MOUSE (Q64462) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1)| Length = 511 Score = 105 bits (263), Expect = 1e-22 Identities = 67/192 (34%), Positives = 104/192 (54%), Gaps = 3/192 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W +Y +++YP Q+R R+EV + G S + L ++ +TM + E RL Sbjct: 317 HDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWDDLAQMTYLTMCMKECFRL 376 Query: 541 YSPALFMQRKTVADMT-VGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK-NGI 368 Y P + R+ +T V LP G I + I +HR+ VW D + F PLRF + Sbjct: 377 YPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVW-PDPEVFDPLRFSPENM 435 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 TG + P + FS GPR+CIGQ F+M E K AL L +F F+ P + V L+ Sbjct: 436 TG--RHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILR 493 Query: 187 PKFGLQVFVRPL 152 K G+ ++++PL Sbjct: 494 SKNGIHLYLKPL 505
>CP4B1_HUMAN (P13584) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-HP)| Length = 511 Score = 105 bits (261), Expect = 2e-22 Identities = 65/191 (34%), Positives = 101/191 (52%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 H+ T+ ++W +Y +++YPE Q R R+EV + G Q + L K+ +TM + E+ RL Sbjct: 317 HDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRL 376 Query: 541 YSPALFMQRKTVADMT-VGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ +T V LP G I + I +HR+ VW D + F LRF Sbjct: 377 YPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW-PDPEVFDSLRFSTE-N 434 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + + P + FS GPR+CIGQ F+M E K A+ L +F F+L P + + L+ Sbjct: 435 ASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRS 494 Query: 184 KFGLQVFVRPL 152 K G + ++PL Sbjct: 495 KNGFHLHLKPL 505
>C13A7_CAEEL (Q27519) Putative cytochrome P450 CYP13A7 (EC 1.14.-.-)| Length = 518 Score = 104 bits (260), Expect = 2e-22 Identities = 65/172 (37%), Positives = 100/172 (58%), Gaps = 5/172 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP----NALNKLKEMTMVLFET 551 ++ T+L L++S YLL+ +PE Q++L++EV +E PDP + L+KLK + V+ E Sbjct: 328 YDTTALSLSYSSYLLATHPEIQKKLQEEVDRE----CPDPEVTFDQLSKLKYLECVVKEA 383 Query: 550 LRLYSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 LRLY A L RK + V +++ G I + +H D +VWGDD +EFKP R+++ Sbjct: 384 LRLYPLASLVHNRKCLKTTNVLGMEIEAGTNINVDTWSLHHDPKVWGDDVNEFKPERWES 443 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYV 218 G G L F MGPR CIG +M+E K L +L+ ++F +P+ V Sbjct: 444 G-DELFFAKGGYLPFGMGPRICIGMRLAMMEMKMLLTNILKNYTFETTPETV 494
>C13A1_CAEEL (Q27520) Putative cytochrome P450 CYP13A1 (EC 1.14.-.-)| Length = 519 Score = 104 bits (259), Expect = 3e-22 Identities = 56/160 (35%), Positives = 92/160 (57%), Gaps = 1/160 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T+L L+++ YLL+ +PE Q++L++EV +E + L+KLK M V E LRLY Sbjct: 329 DTTALSLSYATYLLATHPEIQKKLQEEVNRECPNPEVTIDQLSKLKYMECVFKEALRLYP 388 Query: 535 PALFMQ-RKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 F R+ + + +G++K+ G I + +H D +WGDDA++FKP R++ + Sbjct: 389 LGAFANSRRCMRNTKLGNMKVEVGTMIQVDTWTLHTDPNIWGDDAEDFKPERWQTPNSDQ 448 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 G + F +GPR CIG + +E K L +L+KF+F Sbjct: 449 IYQKSGYIPFGLGPRQCIGMRLAYMEEKILLVHILRKFTF 488
>C13A4_CAEEL (Q27513) Putative cytochrome P450 CYP13A4 (EC 1.14.-.-)| Length = 520 Score = 104 bits (259), Expect = 3e-22 Identities = 64/170 (37%), Positives = 99/170 (58%), Gaps = 5/170 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP----NALNKLKEMTMVLFET 551 ++ T+L L++S YLL+ +PE Q++L++EV +E PDP + ++KLK M V+ E Sbjct: 328 YDTTALSLSYSSYLLATHPEIQKKLQEEVDRE----CPDPEVTFDQISKLKYMECVVKEA 383 Query: 550 LRLYSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 LR+Y A L RK + V +++ +G + + +H D +VWGDDA EFKP R++ Sbjct: 384 LRMYPLASLVHNRKCMKKTNVLGVEIDEGTNVQVDTWTLHYDPKVWGDDASEFKPERWET 443 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 G G L F MGPR CIG +M+E K L +L+K++F S + Sbjct: 444 G-DELFYAKGGYLPFGMGPRICIGMRLAMMEEKLLLTHILKKYTFDTSTE 492
>CP3AT_PIG (P79401) Cytochrome P450 3A29 (EC 1.14.14.1) (CYPIIIA29)| Length = 503 Score = 104 bits (259), Expect = 3e-22 Identities = 56/161 (34%), Positives = 96/161 (59%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L+ Y L+ +P+ Q++L++E+ F ++P +AL +++ + MV+ ETLRL Sbjct: 307 YETTSSALSLLAYELATHPDVQQKLQEEIEATFPNKAPPTYDALAQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R D+ + + +PKG +V+P+ ++HRD ++W + +EF+P RF Sbjct: 367 YPIAARLERACKKDVEIHGVFVPKGTVVVVPVFVLHRDPDLW-PEPEEFRPERFSKKHKD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 P+ L F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 TIN-PYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSF 465
>CPXB_BACME (P14779) Bifunctional P-450:NADPH-P450 reductase (Cytochrome| P450(BM-3)) (P450BM-3) [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1048 Score = 103 bits (258), Expect = 4e-22 Identities = 66/183 (36%), Positives = 97/183 (53%), Gaps = 4/183 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE TS LL++++Y L P ++ +E + P + +LK + MVL E LRL+ Sbjct: 266 HETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLW 325 Query: 538 SPA----LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 A L+ + TV G L KG +++ IP +HRDK +WGDD +EF+P RF+N Sbjct: 326 PTAPAFSLYAKEDTVLG---GEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFEN- 381 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTL 191 +A H F G R+CIGQ F++ EA L +ML+ F F +Y + TL Sbjct: 382 --PSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTL 439 Query: 190 KPK 182 KP+ Sbjct: 440 KPE 442
>CP3AO_SHEEP (Q29496) Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24)| Length = 503 Score = 103 bits (257), Expect = 5e-22 Identities = 53/161 (32%), Positives = 99/161 (61%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ +Y+L+ +P+ Q++L++E+ F ++P + L +++ + MV+ ETLR+ Sbjct: 307 YETTSNTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQMEYLDMVVNETLRM 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + A+ + R D+ + + +PKG A+ +PI ++HRD ++W + +EF+P RF Sbjct: 367 FPIAVRLDRLCKKDVEIHGVSIPKGTAVTVPIFVLHRDPQLW-PEPEEFRPERFSKKNKD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+CIG F+++ K + +LQ FSF Sbjct: 426 SIN-PYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSF 465
>CYPE_BACSU (O08336) Probable bifunctional P-450:NADPH-P450 reductase 2| [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1054 Score = 102 bits (254), Expect = 1e-21 Identities = 64/193 (33%), Positives = 103/193 (53%), Gaps = 5/193 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE TS LL++++Y L +PE ++ ++E + +P+ + +LK + MVL ETLRLY Sbjct: 269 HETTSGLLSFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLY 328 Query: 538 SPA----LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 A L+ + TV G + KG + + IP +HRD+ WG DA++F+P RF++ Sbjct: 329 PTAPAFSLYAKEDTVLG---GEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFED- 384 Query: 370 ITGAAKVP-HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFT 194 + +P H F G R+CIG F++ EA L L+L+ F Y + T Sbjct: 385 ---PSSIPHHAYKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALT 441 Query: 193 LKPKFGLQVFVRP 155 +KP ++ V+P Sbjct: 442 IKPD-DFKITVKP 453
>C13A5_CAEEL (Q27514) Putative cytochrome P450 CYP13A5 (EC 1.14.-.-)| Length = 520 Score = 102 bits (254), Expect = 1e-21 Identities = 59/164 (35%), Positives = 98/164 (59%), Gaps = 1/164 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 ++ T+L L++S YLL+ +PE Q++L++EV +E + ++KLK M V+ E LR+Y Sbjct: 328 YDTTALSLSYSSYLLARHPEIQKKLQEEVDRECPNPEVTFDQISKLKYMECVVKEALRMY 387 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + RK + + V +++ KG + + +H D +VWG+DA+EF+P R+++G Sbjct: 388 PLASIVHNRKCMKETNVLGVQIEKGTNVQVDTWTLHYDPKVWGEDANEFRPERWESG-DE 446 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS 230 G L F MGPR CIG +M+E K L +L+K++F S Sbjct: 447 LFYAKGGYLPFGMGPRICIGMRLAMMEKKMLLTHILKKYTFETS 490
>CP4S3_DROME (Q9VXY0) Probable cytochrome P450 4s3 (EC 1.14.-.-) (CYPIVS3)| Length = 495 Score = 102 bits (253), Expect = 2e-21 Identities = 63/191 (32%), Positives = 102/191 (53%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 H+ TS + +++ LLS P+ Q+R +E + G + + + V+ ETLR+Y Sbjct: 309 HDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREK------ESMPYLEAVIKETLRIY 362 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 F RK + D+ VG L +PKG +I I ++HRD + + D + F P RF + Sbjct: 363 PSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNF-PDPERFDPDRFL--VNEK 419 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKF 179 P AFS GPR+CIGQ F+MLE K++LA++L+ + F D+ P+ K Sbjct: 420 QMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGN 479 Query: 178 GLQVFVRPLDK 146 G+++ + P D+ Sbjct: 480 GIRLRILPRDE 490
>CP132_MYCTU (P77900) Putative cytochrome P450 132 (EC 1.14.-.-)| Length = 461 Score = 101 bits (252), Expect = 2e-21 Identities = 62/187 (33%), Positives = 96/187 (51%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ ++W YL+++ P+ ++ + E+ GM+ P + L KL T L E+ R + Sbjct: 276 HETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYF 335 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 S + R+ V D + ++ +G +VIPI +H D W D D F P RF T Sbjct: 336 SSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPR-WWPDPDRFDPGRFLRCPTDR 394 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKF 179 + + L F G R CIGQ+F+++E A+M Q F+F L+P Y TL+PK Sbjct: 395 PRCAY--LPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRPKH 452 Query: 178 GLQVFVR 158 G+ V R Sbjct: 453 GVHVIGR 459
>CP132_MYCBO (P59954) Putative cytochrome P450 132 (EC 1.14.-.-)| Length = 461 Score = 101 bits (252), Expect = 2e-21 Identities = 62/187 (33%), Positives = 96/187 (51%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ ++W YL+++ P+ ++ + E+ GM+ P + L KL T L E+ R + Sbjct: 276 HETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYF 335 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 S + R+ V D + ++ +G +VIPI +H D W D D F P RF T Sbjct: 336 SSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPR-WWPDPDRFDPGRFLRCPTDR 394 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKF 179 + + L F G R CIGQ+F+++E A+M Q F+F L+P Y TL+PK Sbjct: 395 PRCAY--LPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRPKH 452 Query: 178 GLQVFVR 158 G+ V R Sbjct: 453 GVHVIGR 459
>C13A3_CAEEL (Q27517) Putative cytochrome P450 CYP13A3 (EC 1.14.-.-)| Length = 520 Score = 101 bits (252), Expect = 2e-21 Identities = 65/178 (36%), Positives = 104/178 (58%), Gaps = 5/178 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP----NALNKLKEMTMVLFET 551 ++ T+L L++S YLL+ +PE Q++L++EV +E PDP + L+KLK M V+ ET Sbjct: 328 YDTTALSLSYSSYLLARHPEIQKKLQEEVDRE----CPDPEVTFDQLSKLKYMECVIKET 383 Query: 550 LRLYSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 LRLY A + RK + TV +K+ +G + +H D + WG++A+EFKP R+++ Sbjct: 384 LRLYPLASIVHNRKCMKSTTVLGMKIEEGTNVQADTWTLHYDPKFWGENANEFKPERWES 443 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI 200 G A L F +GPR CIG + +E K LA +L+K+S + + H P+ + Sbjct: 444 G-DEQAVAKGAYLPFGLGPRICIGMRLAYMEEKMLLAQILKKYSLETTFE-THIPLKL 499
>CP3AG_MOUSE (Q64481) Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16)| Length = 504 Score = 101 bits (251), Expect = 3e-21 Identities = 55/161 (34%), Positives = 96/161 (59%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS +L+++VY L+ +P+ Q++L++E+ + ++P + + ++ + MVL ETLRL Sbjct: 308 YETTSSILSFTVYSLATHPDIQKKLQEEIDEALPNKAPPTYDTVMAMEYLDMVLNETLRL 367 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y +QR D+ + + +PKG ++IP ++H D + W + +EF+P RF G Sbjct: 368 YPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHW-PEPEEFQPERFSKENKG 426 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+CIG F+++ K L +LQ FSF Sbjct: 427 SID-PYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSF 466
>CP4FC_HUMAN (Q9HCS2) Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)| Length = 524 Score = 101 bits (251), Expect = 3e-21 Identities = 70/195 (35%), Positives = 109/195 (55%), Gaps = 5/195 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV LK+ + + + L +L +TM + E+L Sbjct: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ PA F+ R D+ + + +PKGI +I I +H + VW D + + P RF + Sbjct: 390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DP 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI-FT 194 + P + FS GPR+CIGQ F+M E K LALML F F PD+ + Sbjct: 448 ENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFL--PDHTEPRRKLELI 505 Query: 193 LKPKFGLQVFVRPLD 149 ++ + GL + V PL+ Sbjct: 506 MRAEGGLWLRVEPLN 520
>CP3AC_CANFA (P24463) Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12)| (P450-PBD-1) Length = 503 Score = 100 bits (250), Expect = 3e-21 Identities = 56/161 (34%), Positives = 97/161 (60%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRL 542 +E TS L++ +Y L+ +P+ Q++L++E+ F ++ P +AL +++ + MVL ETLRL Sbjct: 307 YETTSTSLSFLMYELATHPDVQQKLQEEIDATFPNKALPTYDALVQMEYLDMVLNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R D+ + + +PKG +++P +HRD+ +W + +EF+P RF Sbjct: 367 YPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLW-PEPEEFRPERFSRKNKD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 SIN-PYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSF 465
>C13A6_CAEEL (Q27515) Putative cytochrome P450 CYP13A6 (EC 1.14.-.-)| Length = 518 Score = 100 bits (249), Expect = 4e-21 Identities = 61/186 (32%), Positives = 102/186 (54%), Gaps = 8/186 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA----LNKLKEMTMVLFETL 548 + T+L L+++ YLL+ +PE Q +L++EV +E PDP L+KLK + V+ ETL Sbjct: 327 DTTALSLSYATYLLATHPEIQTKLQEEVDRE----CPDPEIFFDHLSKLKYLECVMKETL 382 Query: 547 RLYSPALFMQ-RKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RLY RK + + T+ + +G+ I + +H + +WG+D ++FKP R++NG Sbjct: 383 RLYPLGTTANTRKCMRETTINGVNFDEGMNIQVDTWTLHHNPRIWGEDVEDFKPERWENG 442 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI--- 200 + + F GPR CIG + +E K LA +L+++SF + + PV + Sbjct: 443 ACEHLEHNGSYIPFGSGPRQCIGMRLAQMEQKILLAQILKEYSFRTTKN-TQIPVKLVGK 501 Query: 199 FTLKPK 182 TL P+ Sbjct: 502 LTLSPE 507
>CP4Z1_HUMAN (Q86W10) Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1)| Length = 505 Score = 100 bits (249), Expect = 4e-21 Identities = 67/192 (34%), Positives = 103/192 (53%), Gaps = 5/192 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 H+ TS ++W +Y L+ YPE Q+R R E+ + G S L+++ TM + E LRL Sbjct: 316 HDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRL 375 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y+P + + R +T LP GI + I I +H + W +D F PLRF Sbjct: 376 YAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW-EDPQVFNPLRFSR--E 432 Query: 364 GAAKV-PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI--FT 194 + K+ P+ + FS G R+CIGQ+F+++E K +AL L +F L+PD+ P + Sbjct: 433 NSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFK--LAPDHSRPPQPVRQVV 490 Query: 193 LKPKFGLQVFVR 158 LK K G+ VF + Sbjct: 491 LKSKNGIHVFAK 502
>CP3AJ_CAPAE (P79152) Cytochrome P450 3A19 (EC 1.14.14.1) (CYPIIIA19) (Fragment)| Length = 218 Score = 99.8 bits (247), Expect = 8e-21 Identities = 54/165 (32%), Positives = 100/165 (60%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ +Y L+ +P+ Q++L++E+ F ++P +AL +++ + MV+ ETLR+ Sbjct: 18 YETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNKAPPTYDALVQMEYLDMVVNETLRM 77 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 + A ++R D+ + + +PKG +++P+ ++H + E W + +EF+P RF K+ Sbjct: 78 FPIAGRLERLCKKDVEIHGVSIPKGTTVMVPLFVLHNNPEFW-PEPEEFRPERFSKKNKD 136 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 GI P+ L F GPR+C+G F+++ K L +LQ FSF Sbjct: 137 GIN-----PYVYLPFGTGPRNCVGMRFALMNIKLALVRILQNFSF 176
>CP4AB_HUMAN (Q02928) Cytochrome P450 4A11 precursor (EC 1.14.15.3) (CYPIVA11)| (Fatty acid omega-hydroxylase) (P-450 HK omega) (Lauric acid omega-hydroxylase) (CYP4AII) (P450-HL-omega) Length = 519 Score = 99.4 bits (246), Expect = 1e-20 Identities = 65/191 (34%), Positives = 101/191 (52%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W +Y L+ +P+ QER R+E+ G S N L+++ TM + E LRL Sbjct: 323 HDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRL 382 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ +T LPKGI +++ I +H + +VW + + F P RF Sbjct: 383 YPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNPEVFDPFRFA---P 438 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 G+A+ H L FS G R+CIG+ F+M E K AL L +F P + P+ LK Sbjct: 439 GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKS 498 Query: 184 KFGLQVFVRPL 152 K G+ + +R L Sbjct: 499 KNGIHLRLRRL 509
>CP4AC_MOUSE (Q91WL5) Cytochrome P450 4A12 (EC 1.14.14.1) (CYPIVA12)| Length = 508 Score = 99.0 bits (245), Expect = 1e-20 Identities = 64/191 (33%), Positives = 99/191 (51%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ PE Q+R RKE+ G S N L+K+ TM + E LR+ Sbjct: 321 HDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRI 380 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ + +T LPKGI +++ +H + VW + + F P RF Sbjct: 381 YPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVW-PNPEVFDPSRFA---P 436 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 G+++ H L FS G R+CIG+ F+M E K +AL L +F P V P+ LK Sbjct: 437 GSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKS 496 Query: 184 KFGLQVFVRPL 152 K G+ + ++ L Sbjct: 497 KNGIHLHLKKL 507
>C13A2_CAEEL (Q27518) Putative cytochrome P450 CYP13A2 (EC 1.14.-.-)| Length = 515 Score = 98.6 bits (244), Expect = 2e-20 Identities = 55/160 (34%), Positives = 90/160 (56%), Gaps = 1/160 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T+L L++ YLL++ P+ QE++ +E+ +EFG + L +LK M V+ E LRLY Sbjct: 326 DTTALSLSYVTYLLAVNPKIQEKVIEEIAREFGTSEVEFEKLGRLKYMDCVIKEALRLYP 385 Query: 535 PA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 A + RK + TV +K+ G+ + + +H D E+WG+D EFKP R+ Sbjct: 386 LASISNSRKCMKTTTVNGVKIEAGVYVQMDTWSLHYDPELWGEDVKEFKPERWSTDEPLE 445 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 K + L F +GPR CIG +++E K L +L+ ++F Sbjct: 446 HKGAY--LPFGLGPRQCIGMRLAIMEQKILLTHLLKNYTF 483
>C13AA_CAEEL (Q09653) Putative cytochrome P450 CYP13A10 (EC 1.14.-.-)| Length = 519 Score = 98.6 bits (244), Expect = 2e-20 Identities = 52/160 (32%), Positives = 95/160 (59%), Gaps = 1/160 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T+L L+++ +LL+ +PE Q++L++E+ +E S + L+KLK M ++ ETLRLY Sbjct: 329 DTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPSISFDHLSKLKYMDCIIKETLRLYP 388 Query: 535 -PALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 + R+ + +G++++ G + + +H D ++WGDDA EFKP R+ + Sbjct: 389 LGTMANSRRCMRATKLGNVEVEVGTMVQVDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQ 448 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 G ++F +GPR C+G + +E K LA +L+K++F Sbjct: 449 VFQKGGYISFGLGPRQCVGMRLAYMEEKMLLAHILRKYTF 488
>C13A8_CAEEL (Q27516) Putative cytochrome P450 CYP13A8 (EC 1.14.-.-)| Length = 509 Score = 98.2 bits (243), Expect = 2e-20 Identities = 55/160 (34%), Positives = 93/160 (58%), Gaps = 1/160 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T++ L++ Y L++ P+ Q +L+ EV KE + L+KLK M V+ E+LRL+ Sbjct: 323 DTTAISLSYVTYFLALNPKIQSKLQDEVDKECPNDEITFDQLSKLKYMDNVIKESLRLFP 382 Query: 535 PALFMQ-RKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 A F R+ + + +G + G+ ++I +H DK VWG+D +EFKP R+ + +T Sbjct: 383 FASFANSRRCMRNTVIGEQIVEAGVDVMIDTWTLHHDKNVWGNDVEEFKPERWDSPLT-- 440 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 L+F GPR C+G F++LE K L+ +L+K++F Sbjct: 441 --PQQAYLSFGAGPRVCLGMRFALLEQKGLLSHILKKYTF 478
>CP4A7_RABIT (P14581) Cytochrome P450 4A7 precursor (EC 1.14.15.3) (CYPIVA7)| (Lauric acid omega-hydroxylase) (P450-KA-2) Length = 511 Score = 98.2 bits (243), Expect = 2e-20 Identities = 67/191 (35%), Positives = 98/191 (51%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE Q R R+E+ G S L+K+ TM + E LRL Sbjct: 324 HDTTASGISWIFYALATHPEHQHRCREEIQGLLGDGASITWEHLDKMPYTTMCIKEALRL 383 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + K + +T LPKGI I + I +H + +VW + + F P RF Sbjct: 384 YPPVPGVGSKLSSPVTFPDGRSLPKGIIITLSIYGLHHNPKVW-PNPEVFDPSRFA---P 439 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 G+A+ H L FS G R+CIG+ F+M E K +AL L +F P V P+ LK Sbjct: 440 GSARHSHAFLPFSGGSRNCIGKQFAMNELKVAVALTLVRFELLPDPTRVPIPITRLVLKS 499 Query: 184 KFGLQVFVRPL 152 K G+ + +R L Sbjct: 500 KNGIHLRLRKL 510
>CP3AS_BOVIN (P79102) Cytochrome P450 3A28 (EC 1.14.14.1) (CYPIIIA28)| Length = 507 Score = 97.8 bits (242), Expect = 3e-20 Identities = 51/161 (31%), Positives = 97/161 (60%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ +Y L+ +P Q++L++E+ F ++P +AL +++ + MV+ ETLR+ Sbjct: 307 YETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNKAPPTYDALVQMEYLDMVVNETLRM 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + A ++R D+ + + +PKG +++P+ ++H + E+W + +EF+P RF Sbjct: 367 FPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELW-PEPEEFRPERFSKNNKD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+C+G F+++ K L +LQ FSF Sbjct: 426 SIN-PYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSF 465
>CP4X1_HUMAN (Q8N118) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)| Length = 509 Score = 97.4 bits (241), Expect = 4e-20 Identities = 66/194 (34%), Positives = 98/194 (50%), Gaps = 2/194 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 H+ + ++W +Y L++ PE QER R+EV G S + L ++ TM + ET RL Sbjct: 318 HDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRL 377 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 + R +T LP GI +V+ I +H + VW + F PLRF Sbjct: 378 IPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KNPKVFDPLRFSQE-N 435 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + P+ L FS G R+CIGQ F+M+E K T+AL+L F T P + F LKP Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKP 495 Query: 184 KFGLQVFVRPLDKC 143 K G+ + ++ L +C Sbjct: 496 KNGMYLHLKKLSEC 509
>CP3AD_MOUSE (Q64464) Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13)| Length = 503 Score = 97.1 bits (240), Expect = 5e-20 Identities = 54/160 (33%), Positives = 95/160 (59%), Gaps = 1/160 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++++YLL+I+P+ Q++L+ E+ ++P + L +++ + MV+ ETLRL Sbjct: 307 YETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R D+ + L +PKG ++IP +H+D + W + +EF+P RF Sbjct: 367 YPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYW-PEPEEFRPERFSKKNQD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 + P+ L F GPR+CIG F+++ K L +LQ F+ Sbjct: 426 SIN-PYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFT 464
>CP3A5_HUMAN (P20815) Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (P450-PCN3)| (HLp2) Length = 502 Score = 96.3 bits (238), Expect = 8e-20 Identities = 55/164 (33%), Positives = 98/164 (59%), Gaps = 4/164 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS +L++++Y L+ +P+ Q++L+KE+ ++P +A+ +++ + MV+ ETLRL Sbjct: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF---KNG 371 + A+ ++R D+ + + +PKG +VIP +H D + W + +EF+P RF K+ Sbjct: 367 FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKKDS 425 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 ID-----PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464
>CP4X1_RAT (Q8K4D6) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)| Length = 507 Score = 95.9 bits (237), Expect = 1e-19 Identities = 64/194 (32%), Positives = 98/194 (50%), Gaps = 2/194 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 H+ ++ ++W +Y L++ PE Q+R R E+ G S L+++ TM + ETLRL Sbjct: 316 HDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEIPYTTMCIKETLRL 375 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 P + R+ +T+ LP G+ +V+ I +H + VW D F PLRF Sbjct: 376 IPPIPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVW-KDPKVFDPLRFTKE-N 433 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + P L FS GPR+CIGQ F+MLE K +AL L +F A L+P Sbjct: 434 SEQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVAADLTRPPAFSSHTVLRP 493 Query: 184 KFGLQVFVRPLDKC 143 K G+ + ++ L +C Sbjct: 494 KHGIYLHLKKLPEC 507
>CP4C3_DROME (Q9VA27) Cytochrome P450 4c3 (EC 1.14.-.-) (CYPIVC3)| Length = 535 Score = 95.1 bits (235), Expect = 2e-19 Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 8/198 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMV---LFETL 548 H+ TS ++W+++LL +PE+QER+ +E+ FG P + L +M + + ++L Sbjct: 344 HDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSL 403 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 RL+ M R D+ +G +P G +I +HR+ V+ ++F P F Sbjct: 404 RLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVF-PKPEQFNPDNFLPE- 461 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI---- 200 A + P + FS GPR+CIGQ F++LE K+ ++ +L+K+ + V D+ Sbjct: 462 NCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI----EAVDRREDLTLLG 517 Query: 199 -FTLKPKFGLQVFVRPLD 149 L+PK GL+V + P D Sbjct: 518 ELILRPKDGLRVKITPRD 535
>CP3A1_RAT (P04800) Cytochrome P450 3A1 (EC 1.14.14.1) (CYPIIIA1) (P450-PCN1)| Length = 504 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/161 (32%), Positives = 95/161 (59%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ ++ L+ +P+ Q++L++E+ + ++P + + +++ + MVL ETLRL Sbjct: 308 YEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRL 367 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y ++R D+ + + +PKG ++IP +HRD + W + +EF+P RF G Sbjct: 368 YPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHW-PEPEEFRPERFSKENKG 426 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+CIG F+++ K L +LQ FSF Sbjct: 427 SID-PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSF 466
>CP4F5_RAT (P51870) Cytochrome P450 4F5 (EC 1.14.14.1) (CYPIVF5)| Length = 526 Score = 94.7 bits (234), Expect = 2e-19 Identities = 59/162 (36%), Positives = 93/162 (57%), Gaps = 4/162 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV + + P+ + L +L +TM + E+L Sbjct: 332 HDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESL 391 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ PA+ + R+ D+ + + +PKG VI I +H + VW D + F P RF + Sbjct: 392 RLHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVW-PDPEVFDPFRFDSE 450 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P + FS GPR+CIGQ F+M E K +AL L +F Sbjct: 451 -NRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRF 491
>CP4V3_MOUSE (Q9DBW0) Cytochrome P450 4V3 (EC 1.14.-.-)| Length = 525 Score = 94.7 bits (234), Expect = 2e-19 Identities = 61/162 (37%), Positives = 92/162 (56%), Gaps = 4/162 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ + WS+YLL PE Q ++ +E+ + FG +S P L KLK + V+ ETL Sbjct: 331 HDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFG-RSHRPVTLEDLKKLKYLDCVIKETL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGI-AIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 R++ R D VG K+ KG AI+IP + HRD + D +EF+P RF Sbjct: 390 RVFPSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYAL-HRDPRYF-PDPEEFRPERFFPE 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P+ + FS GPR+CIGQ F+++E K+ LA +L++F Sbjct: 448 -NSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQF 488
>CP4AA_RAT (P08516) Cytochrome P450 4A10 (EC 1.14.15.3) (CYPIVA10) (Lauric| acid omega-hydroxylase) (P450-LA-omega 1) (P452) Length = 509 Score = 94.0 bits (232), Expect = 4e-19 Identities = 62/191 (32%), Positives = 99/191 (51%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +P+ Q+R R+EV G S + L+++ TM + E LRL Sbjct: 322 HDTTASGVSWIFYALATHPKHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRL 381 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ +T LPKGI + + I +H + +VW + + F P RF Sbjct: 382 YPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVW-PNPEVFDPSRFA---P 437 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + + H L FS G R+CIG+ F+M E K +AL L +F P V P+ LK Sbjct: 438 DSPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPRLVLKS 497 Query: 184 KFGLQVFVRPL 152 K G+ ++++ L Sbjct: 498 KNGIYLYLKKL 508
>CP4F6_RAT (P51871) Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6)| Length = 537 Score = 94.0 bits (232), Expect = 4e-19 Identities = 67/193 (34%), Positives = 102/193 (52%), Gaps = 4/193 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV + + P+ + L +L +TM + E+L Sbjct: 330 HDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ P L + R D+ + + +PKG VI I +H + VW D + + P RF + Sbjct: 390 RLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVW-PDPEVYNPFRF-DP 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTL 191 + P + FS GPR+CIGQ F+M E K LAL L +F L D L Sbjct: 448 ENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFC-VLPDDKEPRRKPELIL 506 Query: 190 KPKFGLQVFVRPL 152 + + GL + V PL Sbjct: 507 RAEGGLWLRVEPL 519
>THAS_MOUSE (P36423) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| (TS) Length = 533 Score = 94.0 bits (232), Expect = 4e-19 Identities = 66/192 (34%), Positives = 99/192 (51%), Gaps = 8/192 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ-SPDPNALNK-LKEMTMVLFETLR 545 HE + L++ YLL+ +P+ QERL KEV G +P+ ++L + L + MV+ ETLR Sbjct: 343 HEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLDMVISETLR 402 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 +Y PA R+ D V ++P G + I + +H D E W + + F P RF T Sbjct: 403 MYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHW-PNPETFDPERF----T 457 Query: 364 GAAKV---PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI-- 200 A++ P L F GPRSC+G +L K T+ +L KF F SP+ P+ + Sbjct: 458 AEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPE-TQVPLQLES 516 Query: 199 -FTLKPKFGLQV 167 L PK G+ + Sbjct: 517 KSALGPKNGVYI 528
>CP341_MOUSE (Q9JMA7) Cytochrome P450 3A41 (EC 1.14.14.1)| Length = 504 Score = 93.6 bits (231), Expect = 5e-19 Identities = 51/161 (31%), Positives = 95/161 (59%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++++Y L+ +P+ Q++L++E+ + ++P + + +++ + MVL ETLRL Sbjct: 308 YETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRL 367 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y ++R D+ + + +PKG ++IP +H D + W + +EF+P RF G Sbjct: 368 YPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHW-PEPEEFQPERFSKENKG 426 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ + F +GPR+CIG F+ + K L ++Q FSF Sbjct: 427 SID-PYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSF 466
>THAS_RAT (P49430) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| Length = 533 Score = 93.6 bits (231), Expect = 5e-19 Identities = 70/193 (36%), Positives = 95/193 (49%), Gaps = 9/193 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNK---LKEMTMVLFETL 548 HE T+ L++ YLL+ +PE QERL KEV F + P P N L + MV+ ETL Sbjct: 343 HEITTNTLSFITYLLATHPECQERLLKEV-DLFMEKHPAPEYCNLQEGLPYLDMVVAETL 401 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 R+Y PA R+ D V +P G + I + +H D E W + + F P RF Sbjct: 402 RMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHW-PNPETFDPERF---- 456 Query: 367 TGAAKV---PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI- 200 T A++ P L F GPRSC+G +L K TL +L KF F P+ P+ + Sbjct: 457 TAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPE-TQVPLQLE 515 Query: 199 --FTLKPKFGLQV 167 L PK G+ V Sbjct: 516 SKSALCPKNGVYV 528
>CP3AE_CAVPO (Q64417) Cytochrome P450 3A14 (EC 1.14.14.1) (CYPIIIA14)| Length = 503 Score = 93.6 bits (231), Expect = 5e-19 Identities = 54/165 (32%), Positives = 93/165 (56%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRL 542 +E TS L++ +Y L+ +P+ Q++L++E+ K ++ P + + +++ + MV+ ETLRL Sbjct: 307 YETTSSTLSFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYDVMMEMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 Y ++R + D + + PKG ++IP +HRD + W + DEF+P RF K Sbjct: 367 YPVTNRIERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYW-PEPDEFRPERFSKKNKE 425 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ + F GPR+CIG +++ K L +LQ FSF Sbjct: 426 NID-----PYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSF 465
>CP4D2_DROME (Q27589) Cytochrome P450 4d2 (EC 1.14.-.-) (CYPIVD2)| Length = 501 Score = 93.6 bits (231), Expect = 5e-19 Identities = 58/173 (33%), Positives = 95/173 (54%), Gaps = 4/173 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ +++ +Y +S +PE Q+RL++E+ G P L +LK M V+ E+L Sbjct: 313 HDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESL 372 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 RL+ P + R D+ + +P G + I ++ RD E + + DEF+P RF + Sbjct: 373 RLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYF-ESPDEFRPERFDADV 431 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS-FTLSPDYVHA 212 P+ + FS GPR+CIGQ F+MLE KST++ +L+ F L P+ H+ Sbjct: 432 PQIH--PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHS 482
>CP4A2_RAT (P20816) Cytochrome P450 4A2 precursor (EC 1.14.15.3) (CYPIVA2)| (Lauric acid omega-hydroxylase) (P450-LA-omega 2) (P450 K-5) (P-450 K-2) Length = 504 Score = 93.2 bits (230), Expect = 7e-19 Identities = 63/191 (32%), Positives = 97/191 (50%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE QER R+EV G S + L+++ TM + E LRL Sbjct: 317 HDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRL 376 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 YSP + R+ + +T +PKGI + I I +H + W + F P RF Sbjct: 377 YSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYW-PNPKVFDPSRFS---P 432 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + + H L FS G R+CIG+ F+M E K +AL L +F P + P+ LK Sbjct: 433 DSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKS 492 Query: 184 KFGLQVFVRPL 152 K G+ + ++ L Sbjct: 493 KNGIHLRLKKL 503
>CP3AB_MOUSE (Q64459) Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11)| (P-450IIIAM1) (P-450UT) Length = 504 Score = 93.2 bits (230), Expect = 7e-19 Identities = 51/161 (31%), Positives = 95/161 (59%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L+++++ L+ +P+ Q++L+ E+ + ++P + + +++ + MVL ETLRL Sbjct: 308 YETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLRL 367 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R D+ + + +PKG ++IP +H D + W + +EF+P RF G Sbjct: 368 YPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHW-SEPEEFQPERFSKENKG 426 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+C+G F+++ K L ++Q FSF Sbjct: 427 SID-PYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSF 466
>C4D10_DROMT (O18596) Cytochrome P450 4d10 (EC 1.14.-.-) (CYPIVD10)| Length = 513 Score = 93.2 bits (230), Expect = 7e-19 Identities = 58/180 (32%), Positives = 96/180 (53%), Gaps = 4/180 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ TS +T+ Y +++YPE Q + +E++ G + P + LN L M + + ETL Sbjct: 319 HDTTSSGITFFFYNIALYPECQRKCVEEIVSVLGKDTETPVTYDLLNNLNYMDLCIKETL 378 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 R+Y + RK + + + +P G I I + R +++ + + FKP RF + + Sbjct: 379 RMYPSVPLLGRKVLQECEINGKIIPAGTNIGISPLFLGRSEDI-SSEPNTFKPERF-DVV 436 Query: 367 TGAAKV-PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTL 191 T A K+ PH + FS GPR+CIGQ F+MLE K+ A +L+ + + +PV I L Sbjct: 437 TSAEKLNPHAYIPFSAGPRNCIGQKFAMLEIKAIAANVLRHYEIEFVGNAEESPVLIAEL 496
>C13B1_CAEEL (O17624) Putative cytochrome P450 cyp-13B1 (EC 1.14.-.-)| Length = 527 Score = 92.8 bits (229), Expect = 9e-19 Identities = 51/158 (32%), Positives = 91/158 (57%), Gaps = 1/158 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T+ L ++ YLL+ +PE + ++EV G ++ + + KLK + V+ E+LRLY Sbjct: 323 DTTANSLAYASYLLAKHPEKMKLAQEEVDTVVGSENVSYDDMTKLKYLDAVVRESLRLYP 382 Query: 535 PALFM-QRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 A F R+ V T+G + + KG+ I + +HR KE+WG++AD+F P R+ + + Sbjct: 383 VAWFACSRECVKPTTLGDIYIDKGVKIEADVMSLHRSKEIWGENADDFVPERW---LEPS 439 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 ++ + F GPR C+G + EAK+ LA +L+++ Sbjct: 440 SRHTMSWIPFGAGPRQCVGMRLGLSEAKTALAHLLRRY 477
>CP3AH_CAVPO (Q64409) Cytochrome P450 3A17 (EC 1.14.14.1) (CYPIIIA17)| Length = 503 Score = 92.8 bits (229), Expect = 9e-19 Identities = 54/165 (32%), Positives = 92/165 (55%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRL 542 +E TS L + +Y L+ +P+ Q++L++E+ K ++ P + + +++ + MV+ ETLRL Sbjct: 307 YETTSSTLCFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYDVMMEMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 Y ++R + D + + PKG ++IP +HRD + W + DEF+P RF K Sbjct: 367 YPVTNRIERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYW-PEPDEFRPERFSKKNKE 425 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ + F GPR+CIG +++ K L +LQ FSF Sbjct: 426 NID-----PYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSF 465
>CP3A2_RAT (P05183) Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2) (P450-PCN2)| (P450/6-beta-A) (Testosterone 6-beta-hydroxylase) Length = 504 Score = 92.4 bits (228), Expect = 1e-18 Identities = 54/161 (33%), Positives = 90/161 (55%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ +Y L+ +P+ Q++L++E+ ++P + + +++ + MVL ETLRL Sbjct: 308 YETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMVLNETLRL 367 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y ++R D+ + L +PKG + IP +H D + W +EF P RF G Sbjct: 368 YPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHW-PKPEEFHPERFSKENKG 426 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + P+ L F GPR+CIG F+++ K L +LQ FSF Sbjct: 427 SID-PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSF 466
>CP3A7_HUMAN (P24462) Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA)| Length = 503 Score = 92.4 bits (228), Expect = 1e-18 Identities = 52/165 (31%), Positives = 97/165 (58%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS +L++ +Y L+ +P+ Q++++KE+ ++P + + +L+ + MV+ ETLRL Sbjct: 307 YETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 + A+ ++R D+ + + +PKG+ ++IP ++H D + W + ++F P RF K+ Sbjct: 367 FPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYW-REPEKFLPERFSKKNKD 425 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 NID-----PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465
>CP3AF_CAVPO (Q64406) Cytochrome P450 3A15 (EC 1.14.14.1) (CYPIIIA15)| Length = 503 Score = 92.0 bits (227), Expect = 2e-18 Identities = 54/165 (32%), Positives = 93/165 (56%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRL 542 +E +S L+ +Y L+ +P+ Q++L +E+ K ++ P + + +++ + MV+ ETLRL Sbjct: 307 YETSSSTLSCIMYSLATHPDVQKKLHQEIDKTLPNKAFPTYDVMMEMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 Y A ++R + D + + PKG ++IP +HRD + W + DEF+P RF K Sbjct: 367 YPVANRIERMSKKDFEINGMSFPKGTLVMIPSFALHRDSKYW-PEPDEFRPERFSKKNKE 425 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ + F GPR+CIG+ +++ K L +LQ FSF Sbjct: 426 NID-----PYIYMPFGNGPRNCIGRRMALMNLKLALIRLLQNFSF 465
>CP3A9_RAT (P51538) Cytochrome P450 3A9 (EC 1.14.14.1) (CYPIIIA9) (P450-OLF3)| (Olfactive) (3AH15) Length = 503 Score = 92.0 bits (227), Expect = 2e-18 Identities = 54/161 (33%), Positives = 92/161 (57%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ +YLL+I+P+ Q++L+ E+ ++ + L +++ + MV+ ETLRL Sbjct: 307 YETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R D+ + + +PKG ++IP +H+D W + +EF+P RF Sbjct: 367 YPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYW-PEPEEFRPERFSKKNQD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 P+ L F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 NIN-PYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSF 465
>CP4AA_MOUSE (O88833) Cytochrome P450 4A10 (EC 1.14.15.3) (CYPIVA10) (Lauric| acid omega-hydroxylase) (P450-LA-omega 1) (P452) Length = 509 Score = 91.7 bits (226), Expect = 2e-18 Identities = 61/191 (31%), Positives = 98/191 (51%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +P+ Q+R R+EV G S + L+++ TM + E LRL Sbjct: 322 HDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRL 381 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ +T LPKG+ + + I +H + +VW + + F P RF Sbjct: 382 YPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVW-PNPEVFDPSRFA---P 437 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + + H L FS G R+CIG+ F+M E K +AL L +F P V P+ LK Sbjct: 438 DSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKS 497 Query: 184 KFGLQVFVRPL 152 K G+ + ++ L Sbjct: 498 KNGIYLHLKKL 508
>CP4A6_RABIT (P14580) Cytochrome P450 4A6 precursor (EC 1.14.15.3) (CYPIVA6)| (Lauric acid omega-hydroxylase) (P450-KA-1) Length = 510 Score = 91.7 bits (226), Expect = 2e-18 Identities = 62/191 (32%), Positives = 96/191 (50%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE Q R R+E+ G S L+++ TM + E LRL Sbjct: 323 HDTTASGISWIFYALATHPEHQHRCREEIQGLLGDGASITWEHLDQMPYTTMCIKEALRL 382 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ + +T LPKG+ + + I +H + +VW + + F P F Sbjct: 383 YPPVPGVGRQLSSPVTFPDGRSLPKGVIVTLSIYALHHNPKVW-PNPEVFDPFPFA---P 438 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 G+A+ H L FS GPR+CIG+ F+M E K +AL L +F P V LK Sbjct: 439 GSARHSHAFLPFSGGPRNCIGKQFAMNELKVAVALTLVRFELLPDPKRVPDQKPRLVLKS 498 Query: 184 KFGLQVFVRPL 152 G+ + +R L Sbjct: 499 SNGIHLRLRKL 509
>CP4F4_RAT (P51869) Cytochrome P450 4F4 (EC 1.14.14.1) (CYPIVF4)| Length = 522 Score = 91.3 bits (225), Expect = 3e-18 Identities = 66/197 (33%), Positives = 101/197 (51%), Gaps = 8/197 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV L++ + + L +L +TM + E+L Sbjct: 330 HDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGD----DADEFKPLR 383 RL+ P + R+ D+ + + +PKG+ +I I H + VW D D F P Sbjct: 390 RLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPEN 449 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVD 203 K+ + P + FS GPR+CIGQ F+M E K LAL L +F L D Sbjct: 450 IKD------RSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFR-VLPDDKEPRRKP 502 Query: 202 IFTLKPKFGLQVFVRPL 152 L+ + GL + V PL Sbjct: 503 ELILRAEGGLWLRVEPL 519
>CP4FE_MOUSE (Q9EP75) Cytochrome P450 4F14 (EC 1.14.13.30) (Leukotriene-B4| omega-hydroxylase) (Leukotriene-B4 20-monooxygenase) (Cytochrome P450-LTB-omega) (Cyp4f-14) Length = 524 Score = 91.3 bits (225), Expect = 3e-18 Identities = 67/194 (34%), Positives = 103/194 (53%), Gaps = 5/194 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV + + P+ + L +L +TM + E+L Sbjct: 330 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQLPFLTMCIKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK-N 374 RL+ P + R D+ + + +PKGI +I I +H + VW D + + P RF Sbjct: 390 RLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVW-PDPEVYDPFRFDPE 448 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFT 194 I ++ P + FS GPR+CIGQ F+M E K LAL L +F L D Sbjct: 449 NIKDSS--PLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRL-LPDDKEPRRQPELI 505 Query: 193 LKPKFGLQVFVRPL 152 L+ + GL + V PL Sbjct: 506 LRAEGGLWLRVEPL 519
>CP3AV_MESAU (O70537) Cytochrome P450 3A31 (EC 1.14.14.1) (CYPIIIA31) (P450| SH3A-1) Length = 501 Score = 91.3 bits (225), Expect = 3e-18 Identities = 52/162 (32%), Positives = 95/162 (58%), Gaps = 3/162 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMT---MVLFETL 548 ++ TS L++++YLL+ +P+ Q++L++E+ + + + + +K+ EM MVL ETL Sbjct: 305 YDTTSSTLSFALYLLATHPDVQKKLQEEI--DIALPNKARPSYDKVMEMEYLDMVLNETL 362 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 RLY ++R D+ + + +PKG +++P+ +H D + W + ++F+P RF Sbjct: 363 RLYPIGSRLERVCKQDVEMDGVFVPKGSIVMVPVFALHYDPQYW-PEPEKFRPERFSKEN 421 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 G+ P+ L F GPR+CIG F+++ K L +LQ FS Sbjct: 422 KGSID-PYIFLPFGNGPRNCIGMRFALMNMKLALTKVLQNFS 462
>CP4AE_MOUSE (O35728) Cytochrome P450 4A14 precursor (EC 1.14.15.3) (CYPIVA14)| (Lauric acid omega-hydroxylase 3) (P450-LA-omega 3) Length = 507 Score = 91.3 bits (225), Expect = 3e-18 Identities = 61/191 (31%), Positives = 95/191 (49%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE Q+R R+EV G S + L ++ TM + E LRL Sbjct: 320 HDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRL 379 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + + R+ + +T +PKGI I I +H + W + F P RF Sbjct: 380 YPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFW-PNPKVFDPSRFA---P 435 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 ++ H L FS G R+CIG+ F+M E K +AL L +F P + P+ LK Sbjct: 436 DSSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKS 495 Query: 184 KFGLQVFVRPL 152 K G+ + ++ L Sbjct: 496 KNGIHLCLKKL 506
>CP4A4_RABIT (P10611) Cytochrome P450 4A4 precursor (EC 1.14.14.1) (CYPIVA4)| (Prostaglandin omega-hydroxylase) (P450-P-2) Length = 510 Score = 90.9 bits (224), Expect = 4e-18 Identities = 62/191 (32%), Positives = 96/191 (50%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE Q R R+E+ G S L+++ TM + E LRL Sbjct: 323 HDTTASGVSWIFYALATHPEHQHRCREEIQGLLGDGASITWEHLDQMPYTTMCIKEALRL 382 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ +T LPKG+ + + I +H + +VW + + F P RF Sbjct: 383 YPPVPSVTRQLSKPVTFPDGRSLPKGVILFLSIYGLHYNPKVW-QNPEVFDPFRFA---P 438 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 +A H L FS G R+CIG+ F+M E K +AL L +F P + P+ LK Sbjct: 439 DSAYHSHAFLPFSGGARNCIGKQFAMRELKVAVALTLVRFELLPDPTRIPIPIARVVLKS 498 Query: 184 KFGLQVFVRPL 152 K G+ + +R L Sbjct: 499 KNGIHLRLRKL 509
>CP4F8_HUMAN (P98187) Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8)| Length = 520 Score = 90.9 bits (224), Expect = 4e-18 Identities = 68/194 (35%), Positives = 102/194 (52%), Gaps = 5/194 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV LK+ + + + L +L +TM L E+L Sbjct: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESL 389 Query: 547 RLYSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ P R D+ + S +PKG I I +H + VW D + + P RF + Sbjct: 390 RLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVW-PDPEVYDPFRF-DP 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH-APVDIFT 194 + P + FS GPR+CIGQ F+M E K LAL L + F + PD+ Sbjct: 448 ENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLR--FRILPDHREPRRTPEIV 505 Query: 193 LKPKFGLQVFVRPL 152 L+ + GL + V PL Sbjct: 506 LRAEDGLWLRVEPL 519
>CP4AC_RAT (P24464) Cytochrome P450 4A12 (EC 1.14.14.1) (CYPIVA12) (CYPIVA8)| (P450-KP1) (P450-PP1) Length = 508 Score = 90.5 bits (223), Expect = 5e-18 Identities = 60/191 (31%), Positives = 95/191 (49%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ PE Q+ RKE+ G S + L+K+ TM + E LR+ Sbjct: 321 HDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRI 380 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R +T LPKGI +++ +H + VW + + F P RF Sbjct: 381 YPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVW-PNPEVFDPYRFA---P 436 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 +++ H L FS G R+CIG+ F+M E K +AL L +F P + P+ LK Sbjct: 437 ESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKS 496 Query: 184 KFGLQVFVRPL 152 K G+ + ++ L Sbjct: 497 KNGIYLRLKKL 507
>CP4F2_HUMAN (P78329) Cytochrome P450 4F2 (EC 1.14.13.30) (CYPIVF2)| (Leukotriene-B(4) omega-hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB-omega) Length = 520 Score = 90.1 bits (222), Expect = 6e-18 Identities = 66/194 (34%), Positives = 103/194 (53%), Gaps = 5/194 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV LK+ + + + L L +TM + E+L Sbjct: 330 HDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ P + R D+ + + +PKGI +I + H + VW D + + P RF + Sbjct: 390 RLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-PDPEVYDPFRF-DP 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH-APVDIFT 194 + P + FS GPR+CIGQ F+M E K LAL L + F + PD+ Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLR--FRVLPDHTEPRRKPELV 505 Query: 193 LKPKFGLQVFVRPL 152 L+ + GL + V PL Sbjct: 506 LRAEGGLWLRVEPL 519
>THAS_PIG (P47787) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| Length = 534 Score = 90.1 bits (222), Expect = 6e-18 Identities = 61/187 (32%), Positives = 92/187 (49%), Gaps = 6/187 (3%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNK---LKEMTMVLFETLRLYSPAL 527 L++ YLL+ P+ QE+L +EV +F + P P + L + MVL ETLR+Y PA Sbjct: 351 LSFVTYLLATNPDCQEKLLREV-DDFSKKHPSPEHCSLQQGLPYLDMVLSETLRMYPPAF 409 Query: 526 FMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAKVP 347 R+ D V ++P G + + + +H D + W + F P RF + P Sbjct: 410 RFTREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHW-PHPETFDPERF-TAEAQRLQQP 467 Query: 346 HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI---FTLKPKFG 176 L F GPRSC+G +LE K TL +L+KF F P+ P+ + L PK G Sbjct: 468 FTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPE-TQVPLQLESKSALSPKNG 526 Query: 175 LQVFVRP 155 + + + P Sbjct: 527 VYIRIVP 533
>CP4A5_RABIT (P14579) Cytochrome P450 4A5 precursor (EC 1.14.15.3) (CYPIVA5)| (Lauric acid omega-hydroxylase) Length = 511 Score = 90.1 bits (222), Expect = 6e-18 Identities = 61/191 (31%), Positives = 94/191 (49%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE Q R R+E+ G S L+++ TM + E +RL Sbjct: 324 HDTTASGVSWIFYALATHPEHQHRCREEIQGLLGDGASITWEHLDQMPYTTMCIKEAMRL 383 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R + +T LPKG + + I +H + VW + + F P RF Sbjct: 384 YPPVPAISRDLSSPVTFPDGRSLPKGFTVTLSIYGLHHNPNVW-PNPEVFDPGRFT---P 439 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 G+A+ H L FS G R+CIG+ F+M E K +AL L +F P + P LK Sbjct: 440 GSARHSHAFLPFSGGARNCIGKQFAMNELKVAVALTLVRFELLPDPTRIPKPTARLVLKS 499 Query: 184 KFGLQVFVRPL 152 G+ + +R L Sbjct: 500 NNGIHLRLRKL 510
>CP4CU_BLAGE (Q964T1) Cytochrome P450 4c21 (EC 1.14.14.1) (CYPIVC21)| Length = 501 Score = 90.1 bits (222), Expect = 6e-18 Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 6/166 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA--LNKLKEMTMVLFETLR 545 H+ S +TW ++ L +PE QE KEV F P LN + + V+ E+LR Sbjct: 311 HDTVSAAMTWLLFELGHHPEIQEEAYKEVQDIFQGSDRVPTMADLNNMNYLERVIKESLR 370 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGD----DADEFKPLRFK 377 L+ ++ R+ D +G +P G I +P +HR+ E++ + + D F P R Sbjct: 371 LHPSVIYFVREAHQDFELGGYTIPAGTNIDFSVPFIHRNPEIFPNPRCFNPDNFLPDRVV 430 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 N + P+ + FS GPR+CIGQ F++LE K L+ +L+ + F Sbjct: 431 N------RHPYAYIPFSAGPRNCIGQRFALLEEKVVLSYLLRHYRF 470
>CP4F1_RAT (P33274) Cytochrome P450 4F1 (EC 1.14.14.1) (CYPIVF1) (P450-A3)| Length = 524 Score = 89.7 bits (221), Expect = 8e-18 Identities = 67/194 (34%), Positives = 102/194 (52%), Gaps = 5/194 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ PE+QER R+EV + + P+ + L +L +TM + E+L Sbjct: 330 HDTTASGLSWILYNLANDPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK-N 374 RL+ P + R D+ + + +PKGI +I I +H + VW D + + P RF Sbjct: 390 RLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVW-PDPEVYNPFRFDPE 448 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFT 194 I ++ P + FS GPR+CIGQ F+M E K LAL L +F L D Sbjct: 449 NIKDSS--PLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRL-LPDDKEPRRQPELI 505 Query: 193 LKPKFGLQVFVRPL 152 L+ + GL + V PL Sbjct: 506 LRAEGGLWLRVEPL 519
>CP3A6_RABIT (P11707) Cytochrome P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (P450-3C)| Length = 501 Score = 89.7 bits (221), Expect = 8e-18 Identities = 56/169 (33%), Positives = 96/169 (56%), Gaps = 7/169 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETL 548 +E TS L++ ++LL+ +P+ Q++L++E+ L + + D L K++ + MV+ ETL Sbjct: 305 YETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYD--TLVKMEYLDMVVNETL 362 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF---- 380 RLY A ++R D+ + +PKG +++P +HRD + W + DEF+P RF Sbjct: 363 RLYPIAGRLERVCKKDVDINGTFIPKGTIVMMPTYALHRDPQHW-TEPDEFRPERFSKKN 421 Query: 379 KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 K+ I P+ F GPR+C+G F+++ K L ++Q FSF L Sbjct: 422 KDNIN-----PYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKL 465
>CP4AE_RAT (P20817) Cytochrome P450 4A14 precursor (EC 1.14.15.3) (CYPIVA14)| (Lauric acid omega-hydroxylase) (P450-LA-omega 3) Length = 507 Score = 89.7 bits (221), Expect = 8e-18 Identities = 62/191 (32%), Positives = 95/191 (49%), Gaps = 2/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL 542 H+ T+ ++W Y L+ +PE QER R+EV G S + L+++ TM + E LRL Sbjct: 320 HDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQIPYTTMCIKEALRL 379 Query: 541 YSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 Y P + R+ + +T +PKGI I I +H + W + F P RF Sbjct: 380 YPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHHNPSYW-PNPKVFDPSRFS---P 435 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + + H L FS G R+CIG+ F+M E K +AL L +F P + P+ LK Sbjct: 436 DSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMARLVLKS 495 Query: 184 KFGLQVFVRPL 152 K G+ + ++ L Sbjct: 496 KNGIHLRLKKL 506
>CP4D8_DROME (Q9VS79) Cytochrome P450 4d8 (EC 1.14.-.-) (CYPIVD8)| Length = 463 Score = 89.0 bits (219), Expect = 1e-17 Identities = 64/195 (32%), Positives = 103/195 (52%), Gaps = 8/195 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA---LNKLKEMTMVLFETL 548 H+ T+ L++ ++ LS +PE Q ++ +E+++ G P + L +LK M V+ E+L Sbjct: 269 HDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESL 328 Query: 547 RLYSPALFMQRKTVADMTV-----GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 R+Y P + RK D G +P G I+I I +HR E + + DEF P R Sbjct: 329 RMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETF-PNPDEFIPER 387 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVD 203 +NG A P ++ FS GPR+CIGQ F+ LE K LA +++++ V V+ Sbjct: 388 HENGSRVA---PFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVN 444 Query: 202 IFTLKPKFGLQVFVR 158 I L+ + G Q+ +R Sbjct: 445 I-VLRSETGFQLGMR 458
>CP56_YEAST (P21595) Cytochrome P450-DIT2 (EC 1.14.14.-) (Cytochrome P450 56)| Length = 489 Score = 89.0 bits (219), Expect = 1e-17 Identities = 65/194 (33%), Positives = 98/194 (50%), Gaps = 14/194 (7%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYP-EWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRL 542 HEN LL S+YLL+ Y EWQE+LRKEV DP L L + LFE +R+ Sbjct: 295 HENPQLLFNSSLYLLAKYSNEWQEKLRKEV-----NGITDPKGLADLPLLNAFLFEVVRM 349 Query: 541 YSP-ALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 Y P + + R T +G+ + +PKG+ + D + WG AD+FKP R+ + I Sbjct: 350 YPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADDFKPERWGSDI 409 Query: 367 T------GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH--- 215 AK + F G R+C+G+ ++ E + +LA ML++F ++L P++ Sbjct: 410 ETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLT 469 Query: 214 --APVDIFTLKPKF 179 P+ LK KF Sbjct: 470 PAGPLCPLNLKLKF 483
>CP134_DROME (Q9VG40) Probable cytochrome P450 313a4 (EC 1.14.-.-)| (CYPCCCXIIIA4) Length = 478 Score = 88.6 bits (218), Expect = 2e-17 Identities = 53/167 (31%), Positives = 95/167 (56%), Gaps = 5/167 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMT---MVLFETLR 545 E T+ + +++ LL+++PE+QER +E+ F + ++M ++L E++R Sbjct: 286 ETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMR 345 Query: 544 LYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-KNG 371 + P + R+T D+ + + + +PKG+ I I I MHR K++WG DA+ F P F + Sbjct: 346 VIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHN 405 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS 230 I K P+ + F+ G R+CIG ++++ AK TLA +L+ + F S Sbjct: 406 IQD--KHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTS 450
>C97B3_ARATH (O23365) Cytochrome P450 97B3 (EC 1.14.-.-)| Length = 580 Score = 88.6 bits (218), Expect = 2e-17 Identities = 60/191 (31%), Positives = 94/191 (49%), Gaps = 29/191 (15%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ +LTW+V+LLS PE + + E+ G P ++ KL+ + +++ E LRL+ Sbjct: 361 HETTAAVLTWAVFLLSQNPEKIRKAQAEIDAVLGQGPPTYESMKKLEYIRLIVVEVLRLF 420 Query: 538 SPALFMQRKTVADMTV--------GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 + R+T+ T+ K+PKG I I + +HR W D+ +F+P R Sbjct: 421 PQPPLLIRRTLKPETLPGGHKGEKEGHKVPKGTDIFISVYNLHRSPYFW-DNPHDFEPER 479 Query: 382 F-----KNGITG----------AAKVPHGLLA------FSMGPRSCIGQNFSMLEAKSTL 266 F NGI G A P+ ++A F GPR CIG F+++E+ L Sbjct: 480 FLRTKESNGIEGWAGFDPSRSPGALYPNEIIADFAFLPFGGGPRKCIGDQFALMESTVAL 539 Query: 265 ALMLQKFSFTL 233 A++ QKF L Sbjct: 540 AMLFQKFDVEL 550
>CP3A3_HUMAN (P05184) Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLp)| Length = 503 Score = 88.6 bits (218), Expect = 2e-17 Identities = 52/165 (31%), Positives = 96/165 (58%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS +L++ +Y L+ +P+ Q++L++E+ ++P + + +++ + MV+ ETLRL Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 + A+ ++R D+ + + +PKG ++IP +HRD + W + ++F P RF K+ Sbjct: 367 FPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKD 425 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 NID-----PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465
>CP3A4_HUMAN (P08684) Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine| 3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.13.97) (NF-25) (P450-PCN1) Length = 502 Score = 88.6 bits (218), Expect = 2e-17 Identities = 52/165 (31%), Positives = 96/165 (58%), Gaps = 5/165 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS +L++ +Y L+ +P+ Q++L++E+ ++P + + +++ + MV+ ETLRL Sbjct: 306 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 365 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 + A+ ++R D+ + + +PKG ++IP +HRD + W + ++F P RF K+ Sbjct: 366 FPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKD 424 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 I P+ F GPR+CIG F+++ K L +LQ FSF Sbjct: 425 NID-----PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 464
>C340_ORYLA (Q98T91) Cytochrome P450 3A40 (EC 1.14.14.1)| Length = 502 Score = 88.2 bits (217), Expect = 2e-17 Identities = 58/192 (30%), Positives = 103/192 (53%), Gaps = 4/192 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA-LNKLKEMTMVLFETLRL 542 +E TS LT+ Y L+ PE ++L+KE+ F ++P L +++ + V+ E+LRL Sbjct: 308 YETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPVQYVPLMEMEYLDCVVNESLRL 367 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R A + V L +PK + +++P +HRD E+W + ++FKP RF Sbjct: 368 YPIAARLERVAKATVEVNGLVIPKDMVVMVPTWPLHRDPELW-PEPEKFKPERFSKENKD 426 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFT---L 191 P+ + F GPR+CIG F+++ K + +LQ + F++ + P ++ L Sbjct: 427 TFD-PYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSVCKE-TEVPFEMDVQGFL 484 Query: 190 KPKFGLQVFVRP 155 PK +Q+ + P Sbjct: 485 APKRPIQLKLTP 496
>CP3A8_MACFA (P33268) Cytochrome P450 3A8 (EC 1.14.14.1) (CYPIIIA8) (P450-MKNF2)| (P-450-MK2) Length = 503 Score = 88.2 bits (217), Expect = 2e-17 Identities = 47/161 (29%), Positives = 93/161 (57%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS +L++ +Y L+ +P+ Q++L++E+ ++P + + +++ + MV+ ETLR+ Sbjct: 307 YETTSSVLSFIIYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQMEYLDMVVNETLRI 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + A+ ++R D+ + + +PKG+ ++IP +H D + W + ++F P RF Sbjct: 367 FPIAMRLERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYW-PEPEKFLPERFSKKNND 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 P+ F GPR+CIG F+++ K + +LQ FSF Sbjct: 426 NID-PYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSF 465
>CP3AA_MESAU (Q64148) Cytochrome P450 3A10 (EC 1.14.13.94) (CYPIIIA10)| (Lithocholate 6-beta-hydroxylase) (6 beta-hydroxylase) Length = 503 Score = 87.4 bits (215), Expect = 4e-17 Identities = 51/160 (31%), Positives = 90/160 (56%), Gaps = 1/160 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E+TS + +Y L+ +P+ Q++L E+ ++P + L ++ + MV+ E LRL Sbjct: 307 YESTSTSICLVLYELATHPDVQKKLHDEIDSALPNKAPVTYDVLMGMEYLDMVINEGLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R + + + L +PKGI +++P +HRD E W + +EF+P RF G Sbjct: 367 YPIANRLERISKKAVEINGLFIPKGITVMVPTYPLHRDPEYW-PEPEEFRPERFSKENKG 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 + P+ + F GPR+CIG F++L K + +LQ F+ Sbjct: 426 SID-PYVYMPFGNGPRNCIGMRFALLSMKLAVVSVLQNFT 464
>CP52W_CANAP (Q12573) Cytochrome P450 52E2 (EC 1.14.14.-) (CYPLIIE2)| Length = 519 Score = 87.0 bits (214), Expect = 5e-17 Identities = 57/182 (31%), Positives = 92/182 (50%), Gaps = 14/182 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKE---MTMVLFETLR 545 + T+ LL+++ Y L YPE + LR+ V+ +FG +P +LK+ + V+ E LR Sbjct: 315 DTTAALLSFTTYYLGAYPEVYDELREAVIADFGSADAEPPTFEQLKQCKVLQNVIREVLR 374 Query: 544 LYSPALFMQRKTVADMTVGS---------LKLPKGIAIVIPIPIMHRDKEVWGDDADEFK 392 L+ R+ +AD T + + +PKG + +M R+ +WG D+ F+ Sbjct: 375 LHPNVPLNFREAIADTTFPTGGGPNGDQPIFVPKGQKVFYATYVMQRNAGIWGPDSTSFR 434 Query: 391 PLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS--FTLSPDYV 218 P R+ N A + F+ GPR C+GQ F++ EA TL + Q+FS L PD + Sbjct: 435 PDRW-NEPREALASGWDYIPFNGGPRICLGQQFALTEASYTLVRICQEFSRIEVLHPDVI 493 Query: 217 HA 212 A Sbjct: 494 TA 495
>CP4F3_HUMAN (Q08477) Cytochrome P450 4F3 (EC 1.14.13.30) (CYPIVF3)| (Leukotriene-B(4) omega-hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB-omega) Length = 520 Score = 87.0 bits (214), Expect = 5e-17 Identities = 65/194 (33%), Positives = 103/194 (53%), Gaps = 5/194 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QER R+EV LK+ + + + L +L +TM + E+L Sbjct: 330 HDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ P + R D+ + + +PKGI +I + H + VW D + + P RF + Sbjct: 390 RLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-PDPEVYDPFRF-DP 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH-APVDIFT 194 + P + FS GPR+CIGQ F+M E K L L L + F + PD+ Sbjct: 448 KNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLR--FRVLPDHTEPRRKPELV 505 Query: 193 LKPKFGLQVFVRPL 152 L+ + GL + V PL Sbjct: 506 LRAEGGLWLRVEPL 519
>THAS_HUMAN (P24557) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| Length = 533 Score = 87.0 bits (214), Expect = 5e-17 Identities = 62/185 (33%), Positives = 90/185 (48%), Gaps = 8/185 (4%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEV--LKEFGMQSPDPNALNKLKEMTMVLFETLRLYSPALF 524 L+++ YLL+ P+ QE+L +EV KE M + L + MV+ ETLR+Y PA Sbjct: 350 LSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFR 409 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAKVPH 344 R+ D V ++P G + + + +H D E W + F P RF T A+ H Sbjct: 410 FTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHW-PSPETFNPERF----TAEARQQH 464 Query: 343 ---GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI---FTLKPK 182 L F GPRSC+G +LE K TL +L KF F P+ P+ + L PK Sbjct: 465 RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPE-TQVPLQLESKSALGPK 523 Query: 181 FGLQV 167 G+ + Sbjct: 524 NGVYI 528
>CP3AL_CALJA (O18993) Cytochrome P450 3A21 (EC 1.14.14.1) (CYPIIIA21) (P450| CM3A-10) Length = 503 Score = 87.0 bits (214), Expect = 5e-17 Identities = 51/162 (31%), Positives = 94/162 (58%), Gaps = 2/162 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 +E TS L++ +Y L+ +P+ Q++L++E+ ++P + + +++ + MV+ ETLRL Sbjct: 307 YETTSSTLSFIMYELATHPDVQQKLQEEIDAVLPNKAPATYDTVLQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-KNGIT 365 + A+ ++R D+ + + +PKG+ ++IP +H D + W + ++F P RF KN Sbjct: 367 FPLAMRLERVCKKDVEINGVFIPKGVVVMIPSYALHYDPKYW-TEPEKFLPERFSKNNKD 425 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 P+ F GPR+CIG F+++ K L +LQ FSF Sbjct: 426 NID--PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 465
>CP3AI_RAT (Q64581) Cytochrome P450 3A18 (EC 1.14.14.1) (CYPIIIA18)| (P450(6)beta-2) Length = 497 Score = 87.0 bits (214), Expect = 5e-17 Identities = 51/160 (31%), Positives = 92/160 (57%), Gaps = 1/160 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 ++ TS +++ +Y L+ P Q++L+ E+ + ++P +AL +++ + MV+ E+LRL Sbjct: 307 YDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALMEMEYLDMVVNESLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A + R + D+ + + +PKG + IPI +HR+ E W + +EF P RF G Sbjct: 367 YPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYW-LEPEEFNPERFSKENKG 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 + P+ L F GPR+CIG F+++ K + +LQ F+ Sbjct: 426 SID-PYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFN 464
>CP4FB_HUMAN (Q9HBI6) Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11)| Length = 524 Score = 86.7 bits (213), Expect = 7e-17 Identities = 64/193 (33%), Positives = 101/193 (52%), Gaps = 4/193 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP---DPNALNKLKEMTMVLFETL 548 H+ T+ L+W +Y L+ +PE+QE+ R+EV + + P + + L +L +TM + E+L Sbjct: 330 HDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESL 389 Query: 547 RLYSPALFMQRKTVADMTVGSLK-LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ P + R D + + +PKGI +I I +H + VW D + + P RF N Sbjct: 390 RLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW-PDPEVYDPFRF-NQ 447 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTL 191 + P + FS GPR+CIGQ F+M E K LAL L F + ++ L Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELI-L 506 Query: 190 KPKFGLQVFVRPL 152 + + GL + V PL Sbjct: 507 RAEGGLWLRVEPL 519
>CP4V2_PONPY (Q5RCN6) Cytochrome P450 4V2 (EC 1.14.-.-)| Length = 525 Score = 86.7 bits (213), Expect = 7e-17 Identities = 53/160 (33%), Positives = 83/160 (51%), Gaps = 2/160 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA--LNKLKEMTMVLFETLR 545 H+ T+ + WS+YLL PE Q+++ E+ FG L KL+ + V+ ETLR Sbjct: 331 HDTTAAAINWSLYLLGCNPEVQQKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR 390 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 L+ R D V ++ KG VI +HRD + + +EF+P RF Sbjct: 391 LFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYF-PNPEEFQPERFFPE-N 448 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P+ + FS GPR+CIGQ F+++E K+ L+ +L+ F Sbjct: 449 AQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488
>CP3AP_MOUSE (O09158) Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25)| Length = 503 Score = 86.3 bits (212), Expect = 9e-17 Identities = 50/160 (31%), Positives = 93/160 (58%), Gaps = 1/160 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 ++ TS ++ +Y L+ +P+ Q++L+ E+ + ++P +AL ++ + MV+ E+LRL Sbjct: 307 YDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A+ ++R + D+ + + +PKG ++IPI +HR+ E W + EF P RF G Sbjct: 367 YPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYW-PEPQEFCPERFSKENKG 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 P+ + F GPR+CIG F+++ K + +LQ F+ Sbjct: 426 NID-PYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFT 464
>CYPD_BACSU (O08394) Probable bifunctional P-450:NADPH-P450 reductase 1| [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1061 Score = 85.9 bits (211), Expect = 1e-16 Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 2/180 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE TS LL+++ Y L +P+ ++ +EV + +P + +L + M+L E+LRL+ Sbjct: 269 HETTSGLLSFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLW 328 Query: 538 SPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A D +G + I + IP +HRD++ WG DA+EF+P RF++ Sbjct: 329 PTAPAFSLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEH---- 384 Query: 361 AAKVP-HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 +VP H F G R+CIG F++ EA L ++L+ F+ +Y TLKP Sbjct: 385 QDQVPHHAYKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKP 444
>CP4V2_HUMAN (Q6ZWL3) Cytochrome P450 4V2 (EC 1.14.-.-)| Length = 525 Score = 85.9 bits (211), Expect = 1e-16 Identities = 53/160 (33%), Positives = 83/160 (51%), Gaps = 2/160 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA--LNKLKEMTMVLFETLR 545 H+ T+ + WS+YLL PE Q+++ E+ FG L KL+ + V+ ETLR Sbjct: 331 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR 390 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 L+ R D V ++ KG VI +HRD + + +EF+P RF Sbjct: 391 LFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYF-PNPEEFQPERFFPE-N 448 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P+ + FS GPR+CIGQ F+++E K+ L+ +L+ F Sbjct: 449 AQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488
>CP4D1_DROSI (O16805) Cytochrome P450 4d1 (EC 1.14.-.-) (CYPIVD1)| Length = 512 Score = 85.9 bits (211), Expect = 1e-16 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 3/179 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ TS L + Y ++ +PE Q++ +E+ G P LN+L + + + ETL Sbjct: 318 HDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETL 377 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 R+Y + RK + D + +P G I I + R +E++ + + FKP RF Sbjct: 378 RMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEP-NSFKPERFDVVT 436 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTL 191 T P+ + FS GPR+CIGQ F+MLE K+ +A +L+ + D PV I L Sbjct: 437 TAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAEL 495
>CP4D1_DROME (P33269) Cytochrome P450 4d1 (EC 1.14.-.-) (CYPIVD1)| Length = 512 Score = 85.9 bits (211), Expect = 1e-16 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 3/179 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ TS L + Y ++ +PE Q++ +E+ G P LN+L + + + ETL Sbjct: 318 HDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETL 377 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 R+Y + RK + D + +P G I I + R +E++ + + FKP RF Sbjct: 378 RMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEP-NSFKPERFDVVT 436 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTL 191 T P+ + FS GPR+CIGQ F+MLE K+ +A +L+ + D PV I L Sbjct: 437 TAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAEL 495
>CP131_DROME (Q9VFJ0) Probable cytochrome P450 313a1 (EC 1.14.-.-)| (CYPCCCXIIIA1) Length = 492 Score = 85.1 bits (209), Expect = 2e-16 Identities = 63/197 (31%), Positives = 103/197 (52%), Gaps = 14/197 (7%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV------LKEFGMQSPDPNALNKLKEMTMVLF 557 ++ ++L + +++LL+ +PE QE + +E+ FG+ PD + KL + V+ Sbjct: 299 YDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPD---MQKLDYLERVIK 355 Query: 556 ETLRLYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF 380 ETLRL R+T D+ + + + +PKG+ I I + HR+ EVWG DAD F P F Sbjct: 356 ETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNF 415 Query: 379 KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF---TLSPDYVHAP 209 K P+ + F+ G R+CIG ++M+ +K L +L+ + TL D V+ Sbjct: 416 L-AENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVY-- 472 Query: 208 VDIFTLK----PKFGLQ 170 VD T+K P+ LQ Sbjct: 473 VDNMTMKLAEYPRLKLQ 489
>CP343_HUMAN (Q9HB55) Cytochrome P450 3A43 (EC 1.14.14.1)| Length = 503 Score = 84.0 bits (206), Expect = 4e-16 Identities = 48/161 (29%), Positives = 91/161 (56%), Gaps = 1/161 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRL 542 ++ TS L + +Y L+ +P+ Q++L++E+ ++P +AL +++ + MV+ ETLRL Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRL 366 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + + R D+ + + +PKG+A+++PI +H D + W + ++F P RF Sbjct: 367 FPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYW-TEPEKFCPERFSKKNKD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + + + + F GPR+CIG F++ K + LQ FSF Sbjct: 426 SIDL-YRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSF 465
>C356_FUNHE (Q8AXY5) Cytochrome P450 3A56 (EC 1.14.14.1) (CYPIIIA56)| Length = 496 Score = 83.6 bits (205), Expect = 6e-16 Identities = 51/167 (30%), Positives = 95/167 (56%), Gaps = 5/167 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRL 542 +E +S LT+ Y L+ PE ++L++E+ F ++P L +++ + V+ E+LRL Sbjct: 306 YETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPNKAPVHYQPLMEMEYLDCVINESLRL 365 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 + A ++R A + + + +PK + ++IP +HRD E+W + + FKP RF K+ Sbjct: 366 FPIAARLERVAKAAVEINGIVIPKDMVVMIPTWPLHRDPEIW-PEPEAFKPERFSKKNKD 424 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 I P+ + F GPR+CIG F+++ K + +LQ++SF++ Sbjct: 425 NID-----PYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSV 466
>C330_FUNHE (Q9PVE8) Cytochrome P450 3A30 (EC 1.14.14.1) (CYPIIIA30)| Length = 496 Score = 83.2 bits (204), Expect = 7e-16 Identities = 51/167 (30%), Positives = 95/167 (56%), Gaps = 5/167 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRL 542 +E +S LT+ Y L+ PE ++L++E+ F ++P L +++ + V+ E+LRL Sbjct: 306 YETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPNKAPVHYQPLMEMEYLDCVINESLRL 365 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----KN 374 + A ++R A + + + +PK + ++IP +HRD E+W + + FKP RF K+ Sbjct: 366 FPIAARLERVAKAAVEINGVVIPKDMVVMIPTWPLHRDPEIW-PEPEAFKPERFSKKNKD 424 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 I P+ + F GPR+CIG F+++ K + +LQ++SF++ Sbjct: 425 NID-----PYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSV 466
>CP136_MYCTU (P95099) Putative cytochrome P450 136 (EC 1.14.-.-)| Length = 492 Score = 83.2 bits (204), Expect = 7e-16 Identities = 53/167 (31%), Positives = 83/167 (49%), Gaps = 1/167 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 H+ ++ T Y L+ +PEWQ+R R E + G D +L +L+ + +V+ E++RL Sbjct: 305 HDTSTSTATTMAYQLAAHPEWQQRCRDESDRH-GDGPLDIESLEQLESLDLVMNESIRLV 363 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 +P + R+TV D + LPKG ++ + HR E+W D F P RF Sbjct: 364 TPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIWTDPL-TFDPERFTEPRNEH 422 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS-PDY 221 + + F G CIG F LE K+ L +L+++ LS PDY Sbjct: 423 KRHRYAFTPFGGGVHKCIGMVFDQLEIKTILHRLLRRYRLELSRPDY 469
>CP17A_MOUSE (P27786) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 507 Score = 82.4 bits (202), Expect = 1e-15 Identities = 61/194 (31%), Positives = 94/194 (48%), Gaps = 8/194 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E TS +L W + L PE + +++KE+ + G ++P N L + + E LR+ Sbjct: 304 ETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIR 363 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A L + K D ++G +PK ++I + +H DK W D D F P RF + Sbjct: 364 PVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEW-DQPDRFMPERFLDPTGS 422 Query: 361 AAKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD-----YVHAPVDI 200 P L F GPRSCIG+ + E +AL+LQ+F F +S D V P + Sbjct: 423 HLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPKVV 482 Query: 199 FTLKPKFGLQVFVR 158 F + P F +++ VR Sbjct: 483 FLIDP-FKVKITVR 495
>CP4P3_DROME (Q9V559) Probable cytochrome P450 4p3 (EC 1.14.-.-) (CYPIVP3)| Length = 515 Score = 82.4 bits (202), Expect = 1e-15 Identities = 53/161 (32%), Positives = 88/161 (54%), Gaps = 3/161 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA--LNKLKEMTMVLFETLR 545 ++ TS+ L + + +S+YPE QE+ +E+ + N LNKLK + + ET+R Sbjct: 324 YDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMR 383 Query: 544 LYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 L+ M R+T + + + L LPKG I + + +HR+ E W D +EF+P RF Sbjct: 384 LFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYW-DSPEEFRPERFLPE- 441 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + + + FS G R+CIGQ F+M E K+ + +L++F Sbjct: 442 NSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQF 482
>CP3AR_ONCMY (O42563) Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27)| Length = 518 Score = 82.4 bits (202), Expect = 1e-15 Identities = 50/174 (28%), Positives = 93/174 (53%), Gaps = 1/174 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRL 542 +E +S +++ Y L+ +L++E+ F ++P AL ++ + VL E+LRL Sbjct: 312 YETSSSTMSFLAYNLATNHHVMTKLQEEIDTVFPNKAPIQYEALMQMDYLDCVLNESLRL 371 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y A ++R + + + +PK +++P +HRD E+W D +EFKP RF Sbjct: 372 YPIAPRLERVAKKTVEINGIVIPKDCIVLVPTWTLHRDPEIW-SDPEEFKPERFSKENKE 430 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI 200 + P+ + F GPR+CIG F+++ K + +LQ F+F++ D P+++ Sbjct: 431 SID-PYTYMPFGAGPRNCIGMRFALIMIKLAMVEILQSFTFSVC-DETEIPLEM 482
>CP139_MYCTU (P63719) Putative cytochrome P450 139 (EC 1.14.-.-)| Length = 430 Score = 82.0 bits (201), Expect = 2e-15 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 3/190 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 +E TS L W++Y L P E EV + G + P + L+ L + V+ ETLRLY Sbjct: 236 YETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLY 295 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-KNGITG 362 SP + R+ + D+ ++ G ++ + HR E+W + EF+PLR+ N Sbjct: 296 SPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIW-PEPTEFRPLRWDPNAADY 354 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH--APVDIFTLK 188 PH + FS G CIG + E LA ++ + L H + L+ Sbjct: 355 RKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANFAALR 414 Query: 187 PKFGLQVFVR 158 P GL V +R Sbjct: 415 PWPGLTVEIR 424
>CP139_MYCBO (P63720) Putative cytochrome P450 139 (EC 1.14.-.-)| Length = 430 Score = 82.0 bits (201), Expect = 2e-15 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 3/190 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 +E TS L W++Y L P E EV + G + P + L+ L + V+ ETLRLY Sbjct: 236 YETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLY 295 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-KNGITG 362 SP + R+ + D+ ++ G ++ + HR E+W + EF+PLR+ N Sbjct: 296 SPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIW-PEPTEFRPLRWDPNAADY 354 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH--APVDIFTLK 188 PH + FS G CIG + E LA ++ + L H + L+ Sbjct: 355 RKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANFAALR 414 Query: 187 PKFGLQVFVR 158 P GL V +R Sbjct: 415 PWPGLTVEIR 424
>CP9E2_BLAGE (Q964T2) Cytochrome P450 9e2 (EC 1.14.-.-) (CYPIXE2)| Length = 533 Score = 81.6 bits (200), Expect = 2e-15 Identities = 60/190 (31%), Positives = 98/190 (51%), Gaps = 7/190 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN----ALNKLKEMTMVLFETL 548 + S LL + +LL+ P+ Q RL+ E+ + ++ D A++ +K + MV+ E+L Sbjct: 337 DTASTLLCFMSHLLATNPDVQNRLQDEI--DQSLEENDGKLTYEAIHSMKYLDMVVSESL 394 Query: 547 RLYSPALFMQRKTVADMTVG---SLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK 377 RLY PA+F RK V + + S L G A+ IPI +H D + + + ++F P RF Sbjct: 395 RLYPPAIFTDRKCVKNYRLPMEPSYTLEPGDAVWIPIYAIHHDPKYY-PNPEKFDPERFS 453 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIF 197 + K P L F GPR+CIG F+++E+K L +L +F+ + P+ I Sbjct: 454 DENKDNIK-PFTYLPFGSGPRNCIGNRFALMESKIALVHLLCRFNLKV---VSKTPIPIK 509 Query: 196 TLKPKFGLQV 167 K F + V Sbjct: 510 ITKKGFNMTV 519
>C97B2_SOYBN (O48921) Cytochrome P450 97B2 (EC 1.14.-.-)| Length = 576 Score = 81.3 bits (199), Expect = 3e-15 Identities = 59/191 (30%), Positives = 92/191 (48%), Gaps = 29/191 (15%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ +LTW+V+LL+ P ++ + EV G P +L +L+ + +++ E LRLY Sbjct: 355 HETTAAVLTWAVFLLAQNPSKMKKAQAEVDLVLGTGRPTFESLKELQYIRLIVVEALRLY 414 Query: 538 -SPALFMQRKTVADMTVGSLK-------LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 P L ++R +D+ G K +P G + I + +HR W D D+F+P R Sbjct: 415 PQPPLLIRRSLKSDVLPGGHKGEKDGYAIPAGTDVFISVYNLHRSPYFW-DRPDDFEPER 473 Query: 382 F----KN----GITG-------AAKVPH------GLLAFSMGPRSCIGQNFSMLEAKSTL 266 F KN G G A P+ L F GPR C+G F+++E+ L Sbjct: 474 FLVQNKNEEIEGWAGLDPSRSPGALYPNEVISDFAFLPFGGGPRKCVGDQFALMESTVAL 533 Query: 265 ALMLQKFSFTL 233 ++LQ F L Sbjct: 534 TMLLQNFDVEL 544
>C81E1_GLYEC (P93147) Cytochrome P450 81E1 (EC 1.14.13.89) (Isoflavone| 2'-hydroxylase) (P450 91A4) (CYP GE-3) Length = 499 Score = 80.5 bits (197), Expect = 5e-15 Identities = 54/163 (33%), Positives = 90/163 (55%), Gaps = 2/163 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRLY 539 +++++ L WS+ L +PE ++++ E+ G D + L KL + V+ ETLRLY Sbjct: 305 DSSAVTLEWSMSNLLNHPEVLKKVKDELDTHVGQDRLVDESDLPKLTYLKNVINETLRLY 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 +PA L + T + +G K+P+ ++I +HRD E+W +A FKP RF+ G Sbjct: 365 TPAPLLLPHSTSDECNIGGYKVPQDTIVLINAWAIHRDPELW-TEATTFKPERFEK--KG 421 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 + L+AF MG R+C G+ ++ TLAL++Q F + L Sbjct: 422 ELEK---LIAFGMGRRACPGEGLAIRAISMTLALLIQCFDWKL 461
>CP46A_MOUSE (Q9WVK8) Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol| 24-hydroxylase) (CH24H) Length = 500 Score = 79.3 bits (194), Expect = 1e-14 Identities = 61/189 (32%), Positives = 93/189 (49%), Gaps = 1/189 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRL 542 HE ++ L ++V LS PE RL+ EV + G + D L +L+ ++ VL E+LRL Sbjct: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRL 363 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y PA R + + +++P ++ +M R + + +D F P RF G Sbjct: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLTFNPDRFG---PG 419 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPK 182 A K FS+G RSCIGQ F+ +E K +A +LQ+ F L P + TLKP Sbjct: 420 APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQRFGLQEQATLKPL 479 Query: 181 FGLQVFVRP 155 + +RP Sbjct: 480 DPVLCTLRP 488
>CP4C1_BLADI (P29981) Cytochrome P450 4C1 (EC 1.14.14.1) (CYPIVC1)| Length = 511 Score = 79.0 bits (193), Expect = 1e-14 Identities = 55/195 (28%), Positives = 102/195 (52%), Gaps = 7/195 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF--GMQSPDPNALNKLKEMTMVLFETLR 545 H+ TS + W+++LL +PE Q+++ +E+ F +S L +K + V+ E+LR Sbjct: 316 HDTTSAGICWALFLLGSHPEIQDKVYEELDHIFQGSDRSTTMRDLADMKYLERVIKESLR 375 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGD----DADEFKPLRFK 377 L+ F+ R D +G +P G + + I +HR+++ + + + D F P R Sbjct: 376 LFPSVPFIGRVLKEDTKIGDYLVPAGCMMNLQIYHVHRNQDQYPNPEAFNPDNFLPERV- 434 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF-TLSPDYVHAPVDI 200 A + P+ + FS GPR+CIGQ F+ LE K+ L+ +L+ F ++ ++ Sbjct: 435 -----AKRHPYAYVPFSAGPRNCIGQKFATLEEKTVLSSILRNFKVRSIEKREDLTLMNE 489 Query: 199 FTLKPKFGLQVFVRP 155 L+P+ G++V + P Sbjct: 490 LILRPESGIKVELIP 504
>CP46A_HUMAN (Q9Y6A2) Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol| 24-hydroxylase) (CH24H) Length = 500 Score = 79.0 bits (193), Expect = 1e-14 Identities = 61/189 (32%), Positives = 93/189 (49%), Gaps = 1/189 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRL 542 HE ++ L ++V LS PE RL+ EV + G + D L +L+ ++ VL E+LRL Sbjct: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y PA R + + +++P ++ +M R + + +D F P RF G Sbjct: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLTFNPDRFG---PG 419 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPK 182 A K FS+G RSCIGQ F+ +E K +A +LQ+ F L P + TLKP Sbjct: 420 APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPL 479 Query: 181 FGLQVFVRP 155 + +RP Sbjct: 480 DPVLCTLRP 488
>C4D14_DROME (O46051) Probable cytochrome P450 4d14 (EC 1.14.-.-) (CYPIVD14)| Length = 507 Score = 79.0 bits (193), Expect = 1e-14 Identities = 59/191 (30%), Positives = 93/191 (48%), Gaps = 3/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETL 548 H+ T+ + ++ YLL+ +PE Q R+ +EV G P L +LK + V+ E+L Sbjct: 317 HDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESL 376 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 RL+ + R D + +P ++I I RD + + D ++F P RF Sbjct: 377 RLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYF-PDPEKFIPDRFSMER 435 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 G P FS GPR+CIGQ F+MLE KST++ M++ F + V PV L+ Sbjct: 436 KGEIS-PFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQ-PVLNVILR 493 Query: 187 PKFGLQVFVRP 155 G+ ++P Sbjct: 494 STTGINCGLKP 504
>CP317_DROME (Q9V776) Probable cytochrome P450 317a1 (EC 1.14.-.-)| (CYPCCCXVIIA1) Length = 518 Score = 78.6 bits (192), Expect = 2e-14 Identities = 52/168 (30%), Positives = 91/168 (54%), Gaps = 5/168 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPD--PNALNKLKEMTMVLFETLR 545 +E T+ L++ +Y L+++PE Q R+R+EV K + L M V+ ETLR Sbjct: 322 YEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLR 381 Query: 544 LYSPALFMQRKTVADMTVGSLK---LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 ++ ++ R+T+ D V L K + ++IP +H D +++ D +EFKP R+ + Sbjct: 382 MHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIY-PDPEEFKPDRW-S 439 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS 230 G + + F +G RSCIG F+ L+ + LAL+L ++ F+L+ Sbjct: 440 GPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLN 487
>CP52C_CANMA (P16496) Cytochrome P450 52A3 (EC 1.14.14.-) (CYPLIIA3)| (Alkane-inducible P450-ALK1-A) (P450-CM1) (CYP52A3-A) (Cytochrome P-450ALK) Length = 522 Score = 78.6 bits (192), Expect = 2e-14 Identities = 59/200 (29%), Positives = 94/200 (47%), Gaps = 15/200 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP------NALNKLKEMTMVLFE 554 + T+ LL+++++ L+ P+ +LR+EV FG+ L K + + VL E Sbjct: 322 DTTAGLLSFAMFELARNPKIWNKLREEVEVNFGLGDEARVDEISFETLKKCEYLKAVLNE 381 Query: 553 TLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 TLR+Y R D T+ + +PKG ++V + HR K+ +G+DA Sbjct: 382 TLRMYPSVPINFRTATRDTTLPRGGGKDGNSPIFVPKGSSVVYSVYKTHRLKQFYGEDAY 441 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 EF+P R+ T K+ L F+ GPR C+GQ F++ EA +A + Q F S D Sbjct: 442 EFRPERWFEPST--RKLGWAYLPFNGGPRICLGQQFALTEASYVIARLAQMFEHLESKDE 499 Query: 220 VHAPVDIFTLKPKFGLQVFV 161 + P L VF+ Sbjct: 500 TYPPNKCIHLTMNHNEGVFI 519
>CP52V_CANAP (P43083) Cytochrome P450 52E1 (EC 1.14.14.-) (CYPLIIE1)| Length = 519 Score = 78.2 bits (191), Expect = 2e-14 Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 14/180 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG---MQSPDPNALNKLKEMTMVLFETLR 545 + T+ LL++ Y L YPE LR+ VL EFG +++P L + K + V+ E LR Sbjct: 315 DTTAGLLSFITYYLGAYPEVYAELREAVLSEFGSTDVETPTFEQLKQCKVLQNVIREVLR 374 Query: 544 LYSPALFMQRKTVADMTVGS---------LKLPKGIAIVIPIPIMHRDKEVWGDDADEFK 392 L+ R+ + D + + + +PKG + M R ++WG DA F+ Sbjct: 375 LHPNVPLNFRQAIVDTKLPTGGGPNGDQPVFVPKGQNVFYSTYSMQRRTDIWGPDATTFR 434 Query: 391 PLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS--FTLSPDYV 218 P R+ N A + F+ GPR C+GQ F++ EA T+ + Q+FS L PD + Sbjct: 435 PDRW-NEPREALASGWDYIPFNGGPRICLGQQFALTEASYTIVRICQEFSRIEVLHPDVI 493
>C6A13_DROME (Q9V4U9) Probable cytochrome P450 6a13 (EC 1.14.-.-) (CYPVIA13)| Length = 493 Score = 78.2 bits (191), Expect = 2e-14 Identities = 52/166 (31%), Positives = 89/166 (53%), Gaps = 4/166 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF--GMQSPDPNALNKLKEMTMVLFETLRL 542 + +S +++ +Y L++ P+ QERLR EVL Q +++ ++ + V+ ETLR Sbjct: 298 DTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRK 357 Query: 541 YSPALFMQRKTVADMTV--GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 Y + R++ + + +L L G I+IP+ +H D E++ D ++F P RF+ Sbjct: 358 YPILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELY-PDPEKFDPSRFEPEE 416 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS 230 A+ P L F GPR+CIG+ F L+ K L +L+ F F+ S Sbjct: 417 I-KARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRS 461
>CP52F_CANTR (P30608) Cytochrome P450 52A6 (EC 1.14.14.-) (CYPLIIA6)| (Alkane-inducible P450-ALK3) Length = 524 Score = 77.8 bits (190), Expect = 3e-14 Identities = 52/184 (28%), Positives = 90/184 (48%), Gaps = 15/184 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP------NALNKLKEMTMVLFE 554 + T+ LL+++++ L+ +PE +LR+E+ FG+ +L + + + +L E Sbjct: 324 DTTAGLLSFAMFELARHPEIWSKLREEIEVNFGVGEESRVEEITFESLKRCEYLKAILNE 383 Query: 553 TLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 TLR+Y R D T+ + +PKG + + HR +E +G DAD Sbjct: 384 TLRMYPSVPVNSRTATRDTTLPRGGGPNGTDPIFIPKGSTVAYIVYKTHRLEEYYGKDAD 443 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 +F+P R+ T K+ + F+ GPR C+GQ F++ EA + ++Q F SP Sbjct: 444 DFRPERWFEPST--KKLGWAYVPFNGGPRICLGQQFALTEASYVITRLVQMFETVSSPPD 501 Query: 220 VHAP 209 V P Sbjct: 502 VEYP 505
>C6A14_DROME (Q9V4U7) Probable cytochrome P450 6a14 (EC 1.14.-.-) (CYPVIA14)| Length = 509 Score = 77.4 bits (189), Expect = 4e-14 Identities = 57/173 (32%), Positives = 90/173 (52%), Gaps = 11/173 (6%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNK--LKEMT---MVLFET 551 E +S ++ +Y L++ P+ Q+RLR+E+ E + + D LN L +MT VL ET Sbjct: 316 ETSSSTMSLCLYELALQPDIQQRLREEI--ESVLANVDGGELNYDVLAQMTYLDQVLSET 373 Query: 550 LRLYSPALFMQRKTVADMTV--GSLKLPKGIAIVIPIPIMHRDKEVWGD----DADEFKP 389 LR + + R+T D + + L KGI +IP+ +H D E++ + D F P Sbjct: 374 LRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDP 433 Query: 388 LRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS 230 KN + P L F GPR+CIG F ++AK L +L++F F++S Sbjct: 434 EEVKN------RHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVS 480
>C97B1_PEA (Q43078) Cytochrome P450 97B1 (EC 1.14.-.-) (P450 97A2)| Length = 552 Score = 77.4 bits (189), Expect = 4e-14 Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 29/183 (15%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ +LTW+V+LL+ P+ ++ + EV GM P L KL+ + +++ ETLRLY Sbjct: 364 HETTAAVLTWAVFLLAQNPDKMKKAQAEVDLVLGMGKPTFELLKKLEYIRLIVVETLRLY 423 Query: 538 -SPALFMQRKTVADMTVGSLK-------LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 P L ++R D+ G K +P G + I + +HR W D ++F+P R Sbjct: 424 PQPPLLIRRSLKPDVLPGGHKGDKDGYTIPAGTDVFISVYNLHRSPYFW-DRPNDFEPER 482 Query: 382 F--------KNGITG-------AAKVPH------GLLAFSMGPRSCIGQNFSMLEAKSTL 266 F G G A P+ L F GPR C+G F+++E ST+ Sbjct: 483 FLVQNNNEEVEGWAGFDPSRSPGALYPNEIISDFAFLPFGGGPRKCVGDQFALME--STV 540 Query: 265 ALM 257 AL+ Sbjct: 541 ALV 543
>C505_FUSOX (Q9Y8G7) Bifunctional P-450:NADPH-P450 reductase (Fatty acid| omega-hydroxylase) (P450foxy) [Includes: Cytochrome P450 505 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1066 Score = 77.4 bits (189), Expect = 4e-14 Identities = 58/182 (31%), Positives = 91/182 (50%), Gaps = 4/182 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE TS L++++Y L PE +++KEV + G L KL ++ VL ETLRL Sbjct: 268 HETTSGTLSFAMYQLLKNPEAYSKVQKEVDEVVGRGPVLVEHLTKLPYISAVLRETLRLN 327 Query: 538 SPALFMQRKTVADMTVGSLKL-PKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 SP + + D +G L KG + + H D V+G+DAD+F P R + Sbjct: 328 SPITAFGLEAIDDTFLGGKYLVKKGEIVTALLSRGHVDPVVYGNDADKFIPERMLDDEFA 387 Query: 361 A--AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS-PDYVHAPVDIFTL 191 + P+ F G R+CIG+ F+ E+ + ++ Q F+FT++ P+Y T+ Sbjct: 388 RLNKEYPNCWKPFGNGKRACIGRPFAWQESLLAMVVLFQNFNFTMTDPNYALEIKQTLTI 447 Query: 190 KP 185 KP Sbjct: 448 KP 449
>CP2J3_RAT (P51590) Cytochrome P450 2J3 (EC 1.14.14.1) (CYPIIJ3)| Length = 502 Score = 77.0 bits (188), Expect = 5e-14 Identities = 49/162 (30%), Positives = 80/162 (49%), Gaps = 3/162 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNK--LKEMTMVLFETLRL 542 E TS L W++ +++YPE QE+++ E+ + G Q PN ++ + V+ E R+ Sbjct: 314 ETTSTTLRWALLCMALYPEVQEKMQAEIDRVIG-QGRQPNLADRDSMPYTNAVIHEVQRI 372 Query: 541 YSPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 + F + R+ D + LPKG I+ + +HRD + W D F P F Sbjct: 373 GNIIPFNVPREVAVDTYLAGFNLPKGTMILTNLTALHRDPKEWATP-DTFNPEHFLEN-- 429 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 G K L FSMG R+C+G+ + E + ++QKF+F Sbjct: 430 GQFKKRESFLPFSMGKRACLGEQLARSELFIFITSLIQKFTF 471
>CP312_DROME (Q9VVN6) Probable cytochrome P450 312a1 (EC 1.14.-.-) (CYPCCCXIIA1)| Length = 510 Score = 77.0 bits (188), Expect = 5e-14 Identities = 48/160 (30%), Positives = 84/160 (52%), Gaps = 3/160 (1%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMV---LFETLRLY 539 T+ L + +Y ++++PE Q+R R+EV G +P ++ +++++ + + ETLR+Y Sbjct: 321 TATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMY 380 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 RK A+ T+ +PKG ++I M R K+ + D FKP R+ G Sbjct: 381 PSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPM-VFKPDRWAIGAEPK 439 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + + F G RSC+GQ ++M+ K LA +L+ F F Sbjct: 440 IEAT-TFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF 478
>C4D20_DROME (Q9W011) Probable cytochrome P450 4d20 (EC 1.14.-.-) (CYPIVD20)| Length = 510 Score = 77.0 bits (188), Expect = 5e-14 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 7/194 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA---LNKLKEMTMVLFETLR 545 + TS ++ ++Y ++ +PE Q+R+ +E+ + G + P L LK + V+ ET+R Sbjct: 319 DTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMR 378 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF----K 377 LY P + R ++ +G +P +I + + HRD + D F+P RF + Sbjct: 379 LYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPL-SFRPERFLEDQE 437 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIF 197 G A VP FS GP++CIGQ F++LE K ++ +L +F L P+ F Sbjct: 438 QGHNTFAYVP-----FSAGPKNCIGQKFAVLEMKVLISKVL-RFYELLPLGEELKPMLNF 491 Query: 196 TLKPKFGLQVFVRP 155 L+ G+ V +RP Sbjct: 492 ILRSASGINVGLRP 505
>CP6A9_DROME (Q27594) Cytochrome P450 6a9 (EC 1.14.-.-) (CYPVIA9)| Length = 504 Score = 76.6 bits (187), Expect = 7e-14 Identities = 51/170 (30%), Positives = 93/170 (54%), Gaps = 9/170 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN--ALNKLKEMTMVLFETLRL 542 E +S + +++Y L+ + + Q+R+RKE + G + + ++ + + V+ ETLRL Sbjct: 311 ETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRL 370 Query: 541 YSPALFMQRKTVADMTV-GSLK--LPKGIAIVIPIPIMHRDKEVWGD----DADEFKPLR 383 Y+ + R+ + D V G K + KG+ ++IP MHRD++++ + + D F P R Sbjct: 371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER 430 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 K + L F GPR+CIG F ++A+S LAL++ +F F++ Sbjct: 431 VKE------RDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSV 474
>CP2J2_HUMAN (P51589) Cytochrome P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (Arachidonic| acid epoxygenase) Length = 502 Score = 76.6 bits (187), Expect = 7e-14 Identities = 48/161 (29%), Positives = 77/161 (47%), Gaps = 2/161 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E TS L W++ +++YPE QE+++ E+ + G Q P A + V+ E R+ Sbjct: 314 ETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMG 373 Query: 538 S-PALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + L + R+ D T+ LPKG I+ + +HRD W D F P F G Sbjct: 374 NIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA-TPDTFNPDHFLE--NG 430 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 K + FS+G R+C+G+ + E ++QKF+F Sbjct: 431 QFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTF 471
>CP311_DROME (Q9VYQ7) Probable cytochrome P450 311a1 (EC 1.14.-.-) (CYPCCCXIA1)| Length = 483 Score = 76.3 bits (186), Expect = 9e-14 Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 3/186 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T+ +++ +Y L+ +PE Q RLRKE+ ++ D +ALN L + ++ E LRLY+ Sbjct: 296 DTTTAAMSFVLYALAKFPETQTRLRKELQDVALDETTDLDALNGLPYLEALIKEVLRLYT 355 Query: 535 PALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAA 356 R+T +G G+ + I + + DKE + D FKP R+ A Sbjct: 356 IVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYY-PDPYAFKPERWLPEDGAVA 414 Query: 355 KVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI---FTLKP 185 + FS GP CIG+ +S+L K A ++++F LSP+ AP+ + LK Sbjct: 415 PPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPE--QAPLRLEAQMVLKA 472 Query: 184 KFGLQV 167 + G+ V Sbjct: 473 QQGINV 478
>CP52K_CANMA (Q12589) Cytochrome P450 52A11 (EC 1.14.14.-) (CYPLIIA11)| (Alkane-inducible P450-ALK8) Length = 519 Score = 75.9 bits (185), Expect = 1e-13 Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 17/189 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA------LNKLKE-MTMVLF 557 + T+ LL+++V+ L PE +LR+E+ +FG+ PD L KL E + V+ Sbjct: 318 DTTAGLLSFAVFELGRNPEVWSKLREEIGDKFGLD-PDSRIEDISFELLKLCEYLKAVIN 376 Query: 556 ETLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDA 404 ETLRLY R A+ T+ + + KG ++ + + RD++ +G DA Sbjct: 377 ETLRLYPSVPRNGRFAAANTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYYGKDA 436 Query: 403 DEFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF-SFTLSP 227 +EF+P R+ K+ L F+ GPR C+GQ F++ EA L ++Q F + LSP Sbjct: 437 NEFRPERWFE--PEVRKLGWAFLPFNGGPRICLGQQFALTEASYVLVRLIQSFETLELSP 494 Query: 226 DYVHAPVDI 200 D + P + Sbjct: 495 DAPYPPAKL 503
>CP52J_CANMA (Q12588) Cytochrome P450 52A10 (EC 1.14.14.-) (CYPLIIA10)| (Alkane-inducible P450-ALK7) Length = 519 Score = 75.9 bits (185), Expect = 1e-13 Identities = 57/188 (30%), Positives = 94/188 (50%), Gaps = 16/188 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP------NALNKLKEMTMVLFE 554 + T+ LL+++V+ L PE +LR+E+ +FG+ S L + + VL E Sbjct: 318 DTTAGLLSFAVFELGRNPEVWSKLRQEIGHKFGLDSYSRVEDISFELLKLCEYLKAVLNE 377 Query: 553 TLRLYSP----ALFMQRKTVADMTVGS-----LKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 TLRLY A F + T G + + KG ++ + + RD++ +G DA+ Sbjct: 378 TLRLYPSVPRNARFAAKNTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYYGKDAN 437 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF-SFTLSPD 224 EF+P R+ K+ L F+ GPR C+GQ F++ EA LA ++Q F + LSP+ Sbjct: 438 EFRPERWFE--PEVRKLGWAFLPFNGGPRICLGQQFALTEASYVLARLIQSFETLELSPE 495 Query: 223 YVHAPVDI 200 + P + Sbjct: 496 AAYPPAKL 503
>CP17A_RAT (P11715) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 507 Score = 75.5 bits (184), Expect = 2e-13 Identities = 50/167 (29%), Positives = 83/167 (49%), Gaps = 3/167 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ +L W + L PE +++++KE+ + G ++P N + L + + E LR+ Sbjct: 304 ETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIR 363 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G +PK +V+ + +H D+ W D D+F P RF + Sbjct: 364 PVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEW-DQPDQFMPERFLDPTGS 422 Query: 361 AAKVP-HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 P L F GPRSCIG+ + E AL+LQ+F +S D Sbjct: 423 HLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDD 469
>CP4P1_DROME (Q9V558) Cytochrome P450 4p1 (EC 1.14.-.-) (CYPIVP1)| Length = 513 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/161 (30%), Positives = 88/161 (54%), Gaps = 3/161 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG--MQSPDPNALNKLKEMTMVLFETLR 545 ++ TS+ L + + +S+ P+ QE +E+ + + + D LNKLK + + ET R Sbjct: 322 YDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLKYLEYFMKETTR 381 Query: 544 LYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 L+ M R+ V + + + L LPKG I I + +HR+ + W D +EF+P RF Sbjct: 382 LFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYW-DSPEEFRPERFLPE- 439 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + + + FS G R+CIG+ ++M E K+ + ++L++F Sbjct: 440 NVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQF 480
>CP135_DROME (Q9VGB5) Probable cytochrome P450 313a5 (EC 1.14.-.-)| (CYPCCCXIIIA5) Length = 487 Score = 74.7 bits (182), Expect = 3e-13 Identities = 45/161 (27%), Positives = 87/161 (54%), Gaps = 4/161 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF---GMQSPDPNALNKLKEMTMVLFETLR 545 + S+ + + L++++P++Q+ + +E+ + F G L KL ++ VL ET+R Sbjct: 295 DTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMR 354 Query: 544 LYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 L + R+T + + + +P+G+ ++I I HR+K++WG A+ F P F Sbjct: 355 LIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPE- 413 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 A+ P+ L FS G ++C+G S++ AK LA +L+ + Sbjct: 414 NKRARPPYSYLPFSKGKKTCLGWKLSLISAKLALAKILRNY 454
>C4D21_DROME (Q9VLZ7) Probable cytochrome P450 4d21 (EC 1.14.-.-) (CYPIVD21)| Length = 511 Score = 74.7 bits (182), Expect = 3e-13 Identities = 46/163 (28%), Positives = 92/163 (56%), Gaps = 6/163 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA------LNKLKEMTMVLFE 554 + T+ ++ +++ +S +P+ QE + +E++ G PDP+A L +LK + V+ E Sbjct: 319 DTTTSGVSHALHAISRHPKVQECIYEELVSVLG---PDPDASVTQTKLLELKYLDCVIKE 375 Query: 553 TLRLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 T+RL+ P + R D+ +G + +P +I++ ++RD E + D FKP R+ + Sbjct: 376 TMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPL-VFKPERWMD 434 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 T + P + FS GP++CIGQ F+ L+ K+ ++ +++ + Sbjct: 435 MKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHY 477
>C6A17_DROME (Q9V770) Probable cytochrome P450 6a17 (EC 1.14.-.-) (CYPVIA17)| Length = 501 Score = 74.3 bits (181), Expect = 3e-13 Identities = 50/168 (29%), Positives = 90/168 (53%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPD--PNALNKLKEMTMVLFETLRL 542 E +S + +++Y L+ + Q++LR+E+ FG + + + ++K + V+ ETLR Sbjct: 307 ETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRK 366 Query: 541 YSPALFMQRKTVADMTVGSLK--LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 Y + R T D + K + KG +VIP +H D +++ + + FKP RF + Sbjct: 367 YPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIY-PEPEIFKPERFTDEE 425 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 AA+ L F GPR+CIG F M++ LA +++ + F++SP+ Sbjct: 426 I-AARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPE 472
>CP4E3_DROME (Q9VL92) Cytochrome P450 4e3 (EC 1.14.-.-) (CYPIVE3)| Length = 526 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/161 (28%), Positives = 85/161 (52%), Gaps = 3/161 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM---QSPDPNALNKLKEMTMVLFETL 548 H+ T+ +++SVYLLS +P+ Q +L +E + G +S + K+K + + + E Sbjct: 309 HDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQ 368 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 R+Y F+ R D + +PKG + + + ++ + ++ D F+P RF+ Sbjct: 369 RVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIF-KDPHHFRPERFEE-- 425 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 P L FS GPR+CIGQ F++LE K+ ++ +++ F Sbjct: 426 --EKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSF 464
>CP52E_CANMA (P24458) Cytochrome P450 52A5 (EC 1.14.14.-) (CYPLIIA5)| (Alkane-inducible P450-ALK2-A) (CYP52A3-B) Length = 523 Score = 73.6 bits (179), Expect = 6e-13 Identities = 56/200 (28%), Positives = 92/200 (46%), Gaps = 15/200 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP------NALNKLKEMTMVLFE 554 + T+ LL+++++ L+ P+ +LR+E+ FG+ L K + + VL E Sbjct: 323 DTTAGLLSFAMFELARNPKIWNKLREEIEVNFGLGEEARVDEISFETLKKCEYLKAVLNE 382 Query: 553 TLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 TLR+Y R D T+ + +PKG ++V + HR +E +G DA Sbjct: 383 TLRMYPSVPVNFRTATRDTTLPRGGGKDGTSPIFVPKGSSVVYTVYKTHRLEEYYGKDAY 442 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 EF+P R+ T K+ + F+ GPR C+GQ F++ EA + + Q F S D Sbjct: 443 EFRPERWFEPST--RKLGWAYVPFNGGPRICLGQQFALTEASYVITRLAQMFEHLESKDE 500 Query: 220 VHAPVDIFTLKPKFGLQVFV 161 + P L VF+ Sbjct: 501 TYPPNKCIHLTMNHNEGVFI 520
>CP4E1_DROME (Q9V4T5) Probable cytochrome P450 4e1 (EC 1.14.-.-) (CYPIVE1)| Length = 531 Score = 73.6 bits (179), Expect = 6e-13 Identities = 48/162 (29%), Positives = 85/162 (52%), Gaps = 4/162 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA----LNKLKEMTMVLFET 551 H+ T+ + ++VYLLS +P+ QE+L E G +A ++ +K + + + E Sbjct: 309 HDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEA 368 Query: 550 LRLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RLY F+ R T D + +PKG + + + ++ + V+ D +F+P RF Sbjct: 369 QRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVF-KDPHKFQPERFDRE 427 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 G P + FS GPR+CIGQ F++LE K+ ++ +++ F Sbjct: 428 KPG----PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF 465
>CP132_DROME (Q9VGB4) Probable cytochrome P450 313a2 (EC 1.14.-.-)| (CYPCCCXIIIA2) Length = 493 Score = 73.2 bits (178), Expect = 8e-13 Identities = 48/169 (28%), Positives = 86/169 (50%), Gaps = 4/169 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP---DPNALNKLKEMTMVLFETLR 545 E ++ + +++ LL+++PE QE + E+ + F + L +L + VL ETLR Sbjct: 300 ETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLR 359 Query: 544 LYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 L F R+T+ D+ + + + +PKG+ I I I R+ + WG +A +F P F Sbjct: 360 LMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEK 419 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 + P+ + FS G R+CIG + ++ +K L +L+ + S Y Sbjct: 420 I-HDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPY 467
>CP27A_RABIT (P17177) Cytochrome P450 27, mitochondrial precursor (EC| 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) Length = 535 Score = 72.8 bits (177), Expect = 1e-12 Identities = 55/170 (32%), Positives = 83/170 (48%), Gaps = 6/170 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + TS LTW++Y LS PE Q LRKEV+ Q P + + VL ETLRLY Sbjct: 341 DTTSNTLTWALYHLSKNPEIQAALRKEVVGVVAAGQVPQHKDFAHMPLLKAVLKETLRLY 400 Query: 538 SPALFMQRKTVAD--MTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-KNGI 368 P + + + D + VG PK V + RD + + D F P R+ + G Sbjct: 401 -PVIPANSRIIVDKEIEVGGFLFPKNTQFVFCHYVTSRDPSTFSEP-DTFWPYRWLRKGQ 458 Query: 367 TGAAKVPH--GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 +K H G + F G R+C+G+ + LE + LA ++Q++ L+P+ Sbjct: 459 PETSKTQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQRYELMLAPE 508
>CP17A_CHICK (P12394) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 72.8 bits (177), Expect = 1e-12 Identities = 56/190 (29%), Positives = 99/190 (52%), Gaps = 4/190 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL- 542 E T+ +L W+V L YPE Q+++++E+ ++ G+ + P + L + + E LR+ Sbjct: 308 ETTTTVLKWAVLYLLHYPEVQKKIQEEMDQKIGLARHPHLSDRPLLPYLEATISEGLRIR 367 Query: 541 -YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 SP L + ++AD ++G +PKG +VI + +H D++ W D +EF P RF + Sbjct: 368 PVSP-LLIPHVSLADTSIGEYSIPKGARVVINLWSVHHDEKEW-DKPEEFNPGRFLDEQG 425 Query: 364 GAAKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 P L F G R C+G+ + +E LA +LQ+F+ D + +L+ Sbjct: 426 QHIHSPSPSYLPFGAGIRVCLGEVLAKMELFLFLAWVLQRFTLECPQDQ-----PLPSLE 480 Query: 187 PKFGLQVFVR 158 KFG+ + V+ Sbjct: 481 GKFGVVLQVQ 490
>CP17A_MESAU (P70687) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 511 Score = 72.8 bits (177), Expect = 1e-12 Identities = 49/168 (29%), Positives = 87/168 (51%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ +L+W + L PE +++++KE+ + G ++P N N L + + E LR+ Sbjct: 305 ETTASVLSWIIAFLLHNPEVKKKIQKEIDQNIGFSRTPTFNDRNHLLMLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + + +DM++G +PK ++I + +H ++ W D D F P RF + TG Sbjct: 365 PVAPMLIPHRANSDMSIGEFSIPKFTPVIINLWALHHSEKEW-DQPDRFMPERFLDP-TG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + + L L F G RSCIG+ + E +A +LQ+F + D Sbjct: 423 SHLITPSLSYLPFGAGARSCIGEVLARQELFLFMAHLLQRFDLDVPDD 470
>CP6J1_BLAGE (Q964R1) Cytochrome P450 6j1 (EC 1.14.-.-) (CYPVIJ1)| Length = 501 Score = 72.8 bits (177), Expect = 1e-12 Identities = 48/159 (30%), Positives = 80/159 (50%), Gaps = 4/159 (2%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEV--LKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 +S+ LT+++Y LS++ + Q R E+ + E + ++ +K + MV+ ETLR Y Sbjct: 310 SSMTLTFALYELSVHQDIQTTARTEIKDVLEHHKKKVTYYSIKDMKYLDMVVNETLRKYP 369 Query: 535 PALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 F+ R+ D + L LP G + IP+ +H D + + A +F P RF Sbjct: 370 AIPFLDRRCQEDYPLTQDLMLPAGTGVYIPVYALHHDSKYFPSPA-KFDPERFSE--KNK 426 Query: 358 AKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 +PH + F GPR+CIG F ++ K+ L +L F Sbjct: 427 QNIPHFAYMPFGEGPRNCIGMRFGSMQVKAALIHILSNF 465
>CP133_DROME (Q9VGB3) Probable cytochrome P450 313a3 (EC 1.14.-.-)| (CYPCCCXIIIA3) Length = 492 Score = 72.8 bits (177), Expect = 1e-12 Identities = 49/169 (28%), Positives = 85/169 (50%), Gaps = 4/169 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTM---VLFETLR 545 E T + ++ LL+++PE Q+ + +E+ + F + + L+ M V+ ETLR Sbjct: 300 ETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLR 359 Query: 544 LYSPALFMQRKTVADMTVGS-LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 L F R+T+ D + S + +PKG+ I I I HR+++ WG D F P F Sbjct: 360 LIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPD- 418 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 + P+ + FS G R+CIG + ++ +K L+ +L+ + S Y Sbjct: 419 NVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRY 467
>C28D2_DROME (Q9VMT6) Probable cytochrome P450 28d2 (EC 1.14.-.-) (CYPXXVIIID2)| Length = 501 Score = 72.8 bits (177), Expect = 1e-12 Identities = 49/171 (28%), Positives = 85/171 (49%), Gaps = 8/171 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 E T+L+L + +L PE Q+++RKE+ G + +++L + ++ETLRL+S Sbjct: 308 ETTALVLAHIMLMLGRNPEEQDKVRKEI----GSADLTFDQMSELPHLDACIYETLRLFS 363 Query: 535 PALFMQRKTV-----ADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 P + ++ A+ ++ L G + IP+ +H D + + +D FKP RF Sbjct: 364 PQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYY-EDPLTFKPERFLES 422 Query: 370 ITGAAKVPHG---LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 G K LAF GPR C G F++ + K+ L +L+ F ++P Sbjct: 423 NGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNP 473
>CP4E2_DROME (Q27606) Cytochrome P450 4e2 (EC 1.14.-.-) (CYPIVE2)| Length = 526 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/162 (28%), Positives = 90/162 (55%), Gaps = 4/162 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA----LNKLKEMTMVLFET 551 H+ T+ ++++VYLLS + + Q +L KE + G +A ++++K + + + E Sbjct: 309 HDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEA 368 Query: 550 LRLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 R+Y F+ R T D + +PKG + + + ++ +++V+ D +F+P RF+ Sbjct: 369 QRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVF-KDPHKFRPERFELE 427 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 G P + FS GPR+CIGQ F++LE K+ ++ +++ F Sbjct: 428 KPG----PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF 465
>CP6L1_BLAGE (Q9GQM9) Cytochrome P450 6l1 (EC 1.14.-.-) (CYPVIL1)| Length = 503 Score = 72.0 bits (175), Expect = 2e-12 Identities = 46/159 (28%), Positives = 80/159 (50%), Gaps = 4/159 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN--ALNKLKEMTMVLFETLRL 542 E TS + +++Y L+++PE Q+RLR E+ + + K+ + MV+ E LR Sbjct: 301 ETTSSAMAFAMYELALHPEIQDRLRTEIQEVTACHGGQVTYEGVKKMSYLDMVVSEVLRK 360 Query: 541 YSPALFMQRKTVADMTVGS--LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 Y P F+ R + D + + + KG I + + +HRD ++ D ++F P RF N Sbjct: 361 YPPMSFIDRVCLHDYHIPGTDVVIEKGTPIFVSLLGLHRDS-IFYPDPEDFNPERF-NKE 418 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQ 251 + P + F GPR+CIG ++ K + ++LQ Sbjct: 419 KKSGVHPFSYIPFGDGPRNCIGLRLGLMSVKLVIIMLLQ 457
>C6A23_DROME (Q9V771) Probable cytochrome P450 6a23 (EC 1.14.-.-) (CYPVIA23)| Length = 502 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/168 (28%), Positives = 89/168 (52%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPD--PNALNKLKEMTMVLFETLRL 542 E +S + +++Y L++ + Q++LR E+ + + + ++K + V+ ETLR Sbjct: 308 ETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRK 367 Query: 541 YSPALFMQRKTVADMTVGSLK--LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 Y + R T D + K + KG +VIP +H D E++ + ++FKP RF + Sbjct: 368 YPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIY-PEPEKFKPERFTDEA 426 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 AA+ L F GPR+CIG F +++A LA +++ + F++S + Sbjct: 427 I-AARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTE 473
>CP6A1_MUSDO (P13527) Cytochrome P450 6A1 (EC 1.14.14.1) (CYPVIA1)| Length = 509 Score = 71.6 bits (174), Expect = 2e-12 Identities = 54/169 (31%), Positives = 89/169 (52%), Gaps = 8/169 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETLR 545 E +S + +++Y L+ + Q+RLR+EV + F D +AL + + VL ETLR Sbjct: 308 ETSSSTMGFALYELAQNQQLQDRLREEVNEVFDQFKEDNISYDALMNIPYLDQVLNETLR 367 Query: 544 LYSPAL--FMQRKTVADMTVG---SLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF 380 Y + + R+T+ D V LPKG + IP+ +H D E++ + +EF P RF Sbjct: 368 KYPVGVGSALTRQTLNDYVVPHNPKYVLPKGTLVFIPVLGIHYDPELY-PNPEEFDPERF 426 Query: 379 KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 + + L F GPR+CIG F ++++ LAL+++ F FT+ Sbjct: 427 SPEMV-KQRDSVDWLGFGDGPRNCIGMRFGKMQSRLGLALVIRHFRFTV 474
>C82A1_PEA (Q43068) Cytochrome P450 82A1 (EC 1.14.-.-) (CYPLXXXII) (Fragment)| Length = 544 Score = 71.6 bits (174), Expect = 2e-12 Identities = 60/193 (31%), Positives = 90/193 (46%), Gaps = 6/193 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRLY 539 + T+ LTW++ LL +P E+L++E+ G + + + +NKL + ++ ETLRLY Sbjct: 343 DTTAGTLTWAMCLLLKHPHVLEKLKEELNTYIGKERCVNESDINKLVYLHAIIKETLRLY 402 Query: 538 SPALFMQ-RKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KNGI 368 PA F R+ D T+G + KG ++ + +HRD VW D EFKP RF + Sbjct: 403 PPAPFSSPREFTEDCTIGGYHIKKGTRLMPNLWKIHRDPSVWPDPL-EFKPERFLSTHKD 461 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS-FTLSPDYVH-APVDIFT 194 LL F G R C G + + LA L F SP+ + V F Sbjct: 462 VDVRGQNFELLPFGSGRRMCAGMSLGLHMVHYILANFLHSFEILNPSPESIDVTEVLEFV 521 Query: 193 LKPKFGLQVFVRP 155 L+V V+P Sbjct: 522 TTKATPLEVLVKP 534
>C4G15_DROME (Q9VYY4) Cytochrome P450 4g15 (EC 1.14.-.-) (CYPIVG15)| Length = 574 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/199 (27%), Positives = 100/199 (50%), Gaps = 11/199 (5%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMV---LFETL 548 H+ T+ ++ + L+ I+ + Q+R+ E+ FG S P EM + L ETL Sbjct: 381 HDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFG-DSQRPATFQDTLEMKYLERCLMETL 439 Query: 547 RLYSPALFMQRKTVADMTV--GSLKLPKGIAIVIPIPIMHRDKEVWGD----DADEFKPL 386 R+Y P + R+ D+ + G+ +P+G + + ++HR+ +V+ + D D F P Sbjct: 440 RMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPE 499 Query: 385 RFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF--TLSPDYVHA 212 R N + + + FS GPRSC+G+ ++ML+ K L+ +L+ + L+ Sbjct: 500 RQAN------RHYYAFVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKL 553 Query: 211 PVDIFTLKPKFGLQVFVRP 155 DI LK + G +V ++P Sbjct: 554 QADII-LKREEGFRVRLQP 571
>CP17A_PERLE (Q91Z85) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 71.2 bits (173), Expect = 3e-12 Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 9/195 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ +L W V L PE +++++KE+ + G ++P N N L + + E LR+ Sbjct: 303 ETTTSVLCWIVAFLLHNPEVKKKIQKEIDQNIGFSRTPTFNDRNHLLMLEATIREVLRIR 362 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G +PK +VI + +H +++ W D D F P RF + TG Sbjct: 363 PVAPMLIPHKANIDSSIGEFTIPKDTHVVINLWALHHNEKEW-DQPDRFMPERFLDA-TG 420 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL-----SPDYVHAPVD 203 + + L L F GPR+CIG+ + +A +LQ+F + P P Sbjct: 421 SHLITPSLSYLPFGAGPRACIGEVLARQVLFLYVACLLQRFDLDVPDGAPMPCLKGDPKV 480 Query: 202 IFTLKPKFGLQVFVR 158 +F + P F ++V VR Sbjct: 481 VFLIDP-FKVKVTVR 494
>C4AE1_DROME (O46054) Cytochrome P450 4ae1 (EC 1.14.-.-) (CYPIVAE1)| Length = 496 Score = 71.2 bits (173), Expect = 3e-12 Identities = 53/191 (27%), Positives = 97/191 (50%), Gaps = 3/191 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNK---LKEMTMVLFETL 548 H+ T+ +++ +YLLS + Q++L +E+ +G L+ L ++ V+ E+L Sbjct: 306 HDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESL 365 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 RLY P + R D+ + +P G +V+ + + RD+ ++ D F+P R G Sbjct: 366 RLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPL-VFQPERHL-GE 423 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 P+ + FS GPR+CIGQ F++LE K+ + +++ + V + I L+ Sbjct: 424 EAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKI-VLR 482 Query: 187 PKFGLQVFVRP 155 K G+ V +RP Sbjct: 483 SKSGVNVGLRP 493
>CP2J6_MOUSE (O54750) Cytochrome P450 2J6 (EC 1.14.14.1) (CYPIIJ6) (Arachidonic| acid epoxygenase) Length = 501 Score = 71.2 bits (173), Expect = 3e-12 Identities = 45/161 (27%), Positives = 74/161 (45%), Gaps = 2/161 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 E TS L W++ +++YPE QE+++ E+ + G + A + T + +R Sbjct: 313 ETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVRRMG 372 Query: 535 PA--LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 L + R+ D + LPKG ++ + +HRD + W D F P F G Sbjct: 373 NIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKEWATP-DVFNPEHFLEN--G 429 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 K L FSMG R+C+G+ + E ++QKF+F Sbjct: 430 QFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFTF 470
>CP2J1_RABIT (P52786) Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (P-450IB)| Length = 500 Score = 70.9 bits (172), Expect = 4e-12 Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLYSPA-LF 524 + W + +++YPE QE++ E+ G Q P + L V+ E R+ + L Sbjct: 318 MRWGLLFMALYPEIQEKVHAEIDSVIGQWQQPSMASRESLPYTNAVIHEVQRMGNILPLN 377 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAKVPH 344 + R+ D T+ LPKG ++ + +H+D E W D F P F G K Sbjct: 378 VPREVTVDTTLAGYHLPKGTVVLTNLTALHKDPEEWA-TPDTFNPEHFLE--NGQFKKKE 434 Query: 343 GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + FS+G R+C+G+ + E ++QKF+F Sbjct: 435 AFIPFSIGKRACLGEQLAKSELFIFFTSLMQKFTF 469
>C28C1_DROME (Q9VYT8) Probable cytochrome P450 28c1 (EC 1.14.-.-) (CYPXXVIIIC1)| Length = 505 Score = 70.9 bits (172), Expect = 4e-12 Identities = 52/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEV-LKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 + TS + + LL P+ Q RL +E+ L G PD +AL L ++ E+LR+Y Sbjct: 303 DTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIY 362 Query: 538 SPALFMQRKTVADMTV-GS-----LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK 377 + + + + GS LKL G +++PI +H D +++ + D F+P RF Sbjct: 363 PAGGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLY-PEPDVFRPERFL 421 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 +G K L F GPR C+G + AK+ LA ++Q+F +SP Sbjct: 422 DGGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSP 471
>CP4E5_DROMT (O44221) Cytochrome P450 4e5, mitochondrial precursor (EC 1.14.-.-)| (CYPIVE5) Length = 522 Score = 70.9 bits (172), Expect = 4e-12 Identities = 45/161 (27%), Positives = 83/161 (51%), Gaps = 3/161 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ---SPDPNALNKLKEMTMVLFETL 548 H+ T+ + ++ Y+LS +PE Q +L +E G + ++ +K + + + E Sbjct: 309 HDTTTSGVAFAGYILSRFPEEQRKLYEEQQAVMGNELNRDATFQEISAMKYLDLFIKEAQ 368 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI 368 R+Y F+ R T D + +PKG + + I ++ D V+ ++ F P RF+ Sbjct: 369 RVYPSVPFIGRYTDKDYNIHGTIMPKGTTLNLGIIVLGYDDRVF-EEPHRFYPERFEKQK 427 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 G P + FS GPR+CIGQ F++LE K+ ++ +++ F Sbjct: 428 PG----PFEYVPFSAGPRNCIGQKFALLELKTVISKLVRTF 464
>CP27A_RAT (P17178) Cytochrome P450 27, mitochondrial precursor (EC| 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) Length = 533 Score = 70.5 bits (171), Expect = 5e-12 Identities = 54/169 (31%), Positives = 82/169 (48%), Gaps = 6/169 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEV--LKEFGMQSPDPNALNKLKEMTMVLFETLRL 542 + TS LTW++Y LS PE QE L KEV + FG + P + + V+ ETLRL Sbjct: 340 DTTSNTLTWALYHLSKNPEIQEALHKEVTGVVPFG-KVPQNKDFAHMPLLKAVIKETLRL 398 Query: 541 YSPALFMQRK-TVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKP---LRFKN 374 Y R T + + PK V+ ++ RD V+ + + F+P LR + Sbjct: 399 YPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVF-PEPESFQPHRWLRKRE 457 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 + P G + F G RSC+G+ + LE + L+ ++QK+ LSP Sbjct: 458 DDNSGIQHPFGSVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYEVVLSP 506
>CP52B_CANTR (P30607) Cytochrome P450 52A2 (EC 1.14.14.-) (CYPLIIA2)| (Alkane-inducible P450-ALK2) Length = 522 Score = 70.5 bits (171), Expect = 5e-12 Identities = 52/185 (28%), Positives = 92/185 (49%), Gaps = 16/185 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM------QSPDPNALNKLKEMTMVLFE 554 + T+ LL++ + L+ P +LR+E+ +FG+ + +L + + VL E Sbjct: 321 DTTAGLLSFVFFELARTPRVANKLREEIEDKFGLGQDARVEEISFESLKSCEYLKAVLNE 380 Query: 553 TLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 LRLY R + T+ + + KG ++ + HR+K+++G+DA Sbjct: 381 CLRLYPSVPQNFRVATRNTTLPRGGGKDGLSPVLVRKGQTVMYSVYAAHRNKQIYGEDAL 440 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS-FTLSPD 224 EF+P R+ T K+ L F+ GPR C+GQ F++ EA +LQ+FS T+ P+ Sbjct: 441 EFRPERWFEPET--KKLGWAFLPFNGGPRICLGQQFALTEASYVTVRLLQEFSHLTMDPN 498 Query: 223 YVHAP 209 ++P Sbjct: 499 TEYSP 503
>CP17A_ORYLA (P70085) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 517 Score = 70.1 bits (170), Expect = 7e-12 Identities = 49/184 (26%), Positives = 96/184 (52%), Gaps = 3/184 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ +L W++ L YPE Q+++++E+ ++ G+ + P + L + + E LR+ Sbjct: 314 ETTTTVLKWAITYLIHYPEVQKQIQEELDRKVGVDRPPQLSDRGSLPFLEATIREVLRIR 373 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A L + ++D ++G + KG +VI + +H D++ W + D F P RF + Sbjct: 374 PVAPLLIPHVALSDTSLGDFTVRKGTRVVINLWSLHHDEKEW-TNPDLFNPGRFLSADGS 432 Query: 361 AAKVP-HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + +P L F G R C+G+ + +E L+ +LQ+F+ ++ P + +L+ Sbjct: 433 SLTLPSSSYLPFGAGLRVCLGEALAKMELFLFLSWILQRFTLSVPPSQ-----SLPSLEG 487 Query: 184 KFGL 173 KFG+ Sbjct: 488 KFGV 491
>CP391_DROME (Q9VQD2) Probable cytochrome P450 309a1 (EC 1.14.-.-) (CYPCCCIXA1)| Length = 529 Score = 70.1 bits (170), Expect = 7e-12 Identities = 45/163 (27%), Positives = 75/163 (46%), Gaps = 6/163 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRLY 539 E + +L +Y LS + E QE+LR E+L+ + + +N L + E+LRL Sbjct: 335 ETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLT 394 Query: 538 SPALFMQRKTVADMTVG-----SLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 +P F R + +L L G+ +++P H D +++ +A EF+P RF+N Sbjct: 395 TPIGFFMRICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIY-PEASEFRPDRFEN 453 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 G L F GPR C+G L K+ + +L + Sbjct: 454 GAASVLTKRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNY 496
>CP27A_HUMAN (Q02318) Cytochrome P450 27, mitochondrial precursor (EC| 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) Length = 531 Score = 70.1 bits (170), Expect = 7e-12 Identities = 52/168 (30%), Positives = 79/168 (47%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + TS LTW++Y LS PE QE L +EV+ Q P + + VL ETLRLY Sbjct: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLY 397 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKP---LRFKNGI 368 R ++ V PK V ++ RD + + + F+P LR Sbjct: 398 PVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP-ESFQPHRWLRNSQPA 456 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 T + P G + F G R+C+G+ + LE + LA ++QK+ L+P+ Sbjct: 457 TPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPE 504
>C6A21_DROME (Q9V774) Probable cytochrome P450 6a21 (EC 1.14.-.-) (CYPVIA21)| Length = 504 Score = 70.1 bits (170), Expect = 7e-12 Identities = 51/170 (30%), Positives = 90/170 (52%), Gaps = 9/170 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN--ALNKLKEMTMVLFETLRL 542 E +S + +++Y L+ + Q R+RKE + + + N ++ L + V+ ETLRL Sbjct: 311 ETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRL 370 Query: 541 YSPALFMQRKTVADMTV-GSLK--LPKGIAIVIPIPIMHRDKEVWGD----DADEFKPLR 383 Y+ + R+ + D V G K + KG+ ++IP MHRD++++ + + D F P R Sbjct: 371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER 430 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 K + L F GPR+CIG F ++A+ LAL+++ F F++ Sbjct: 431 VKE------RDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSV 474
>CP17A_FELCA (Q9GMC8) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 70.1 bits (170), Expect = 7e-12 Identities = 51/194 (26%), Positives = 96/194 (49%), Gaps = 8/194 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W+V L +P+ ++L++E+ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVVRWTVAFLLHHPQLYKKLQEEIDQNIGFSRTPTMSDRNQLILLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + K + D ++G + KG ++I + +H +++ W D+F P RF + Sbjct: 365 PVAPTLIPHKAIMDSSIGEFAVDKGTNVIINLWALHHNEKEWYRP-DQFMPERFLDPTRS 423 Query: 361 AAKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS-----PDYVHAPVDI 200 P L F GPRSC+G++ + E +A +LQ+F + P P + Sbjct: 424 QLISPSLSYLPFGAGPRSCLGESLARQEVFLFMAWLLQRFDLEVPDDGQLPHLEGNPTVV 483 Query: 199 FTLKPKFGLQVFVR 158 F + P F ++V VR Sbjct: 484 FLIAP-FKVKVKVR 496
>C28D1_DROME (Q9VMT5) Probable cytochrome P450 28d1 (EC 1.14.-.-) (CYPXXVIIID1)| Length = 502 Score = 70.1 bits (170), Expect = 7e-12 Identities = 53/171 (30%), Positives = 86/171 (50%), Gaps = 8/171 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 E T+ +LT ++ L+ P+ Q +LR+E+ G +++L + ETLR++S Sbjct: 309 ETTAQVLTHTLLFLARNPKEQMKLREEI----GTAELTFEQISELPFTEACIHETLRIFS 364 Query: 535 PALFMQRKTVAD------MTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 P L RK V + S+KL G ++IP+ +H D + + ++ FKP RF N Sbjct: 365 PVL-AARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYY-EEPQSFKPERFLN 422 Query: 373 GITGAAKV-PHGLL-AFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 GA K GL F GPR C G FS+ + K+ L +++ F ++P Sbjct: 423 INGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNP 473
>CP4P2_DROME (Q9V557) Probable cytochrome P450 4p2 (EC 1.14.-.-) (CYPIVP2)| Length = 520 Score = 69.7 bits (169), Expect = 8e-12 Identities = 48/163 (29%), Positives = 90/163 (55%), Gaps = 5/163 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF--GMQSPDPNALNKLKEMTMVLFETLR 545 ++ TS+ L + + +S+Y QE +E+ + + + + + L+KL + + ET+R Sbjct: 327 YDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFIKETMR 386 Query: 544 LYSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KN 374 LY M R+T+ + + L LPK I I + +HR+ + W + +EF+P RF +N Sbjct: 387 LYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYW-ESPEEFRPERFLPQN 445 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + + P+ + FS G R+CIGQ ++M E K+ + ++L+ F Sbjct: 446 CLK---RHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHF 485
>CP2R1_HUMAN (Q6VVX0) Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D| 25-hydroxylase) Length = 501 Score = 69.7 bits (169), Expect = 8e-12 Identities = 53/194 (27%), Positives = 94/194 (48%), Gaps = 3/194 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRLY 539 E T+ +L W++ +++YP Q +++KE+ G P + K+ VL E LR Sbjct: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + L + T D V +PKG ++ + +H D++ W D + F P RF + Sbjct: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP-EVFHPERFLDSSGY 431 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIF-TLKP 185 AK L+ FS+G R C+G++ + +E +LQ+F ++H P ++ LKP Sbjct: 432 FAK-KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF-------HLHFPHELVPDLKP 483 Query: 184 KFGLQVFVRPLDKC 143 + G+ + +P C Sbjct: 484 RLGMTLQPQPYLIC 497
>CP2R1_MOUSE (Q6VVW9) Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D| 25-hydroxylase) Length = 501 Score = 69.3 bits (168), Expect = 1e-11 Identities = 53/194 (27%), Positives = 91/194 (46%), Gaps = 3/194 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRLY 539 E T+ +L W++ +++YP Q ++ KE+ G + P K+ VL E LR Sbjct: 313 ETTTNVLRWAILFMALYPNIQGQVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLHEVLRFC 372 Query: 538 S-PALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + L + T D V +PKG ++ + +H D++ W D D F P RF + G Sbjct: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW-KDPDMFYPERFLDS-NG 430 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIF-TLKP 185 L+ FS+G R C+G+ + +E +LQ+F ++H P ++ LKP Sbjct: 431 YFTKKEALIPFSLGRRHCLGEQLARMEMFLFFTSLLQQF-------HLHFPHELVPNLKP 483 Query: 184 KFGLQVFVRPLDKC 143 + G+ + +P C Sbjct: 484 RLGMTLQPQPYLIC 497
>CP137_MYCTU (O69653) Putative cytochrome P450 137 (EC 1.14.-.-)| Length = 476 Score = 69.3 bits (168), Expect = 1e-11 Identities = 57/189 (30%), Positives = 88/189 (46%), Gaps = 1/189 (0%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ L W+ LL +P+ R+R E + G ++ T V+ ETLR+ Sbjct: 303 HETTATTLAWAFDLLLHHPDALRRVRAEAVG--GGEA----------FTTAVINETLRVR 350 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 PA R +T+G ++ G IV+ I ++R EV+ + EF+P RF G Sbjct: 351 PPAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVY-EHPHEFRPERF----LGT 405 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPV-DIFTLKPK 182 + + F G + C+G NFSM E + L ++L++ FT D V L P+ Sbjct: 406 RPQTYAWVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAVDDEPERIVRRSIMLVPR 465 Query: 181 FGLQVFVRP 155 G +V RP Sbjct: 466 RGTRVRFRP 474
>CP6A2_DROME (P33270) Cytochrome P450 6a2 (EC 1.14.-.-) (CYPVIA2) (P450-B1)| Length = 506 Score = 69.3 bits (168), Expect = 1e-11 Identities = 48/162 (29%), Positives = 83/162 (51%), Gaps = 5/162 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN--ALNKLKEMTMVLFETLRL 542 E +S +++ +Y L+ + Q+RLR E+ Q ++ + + V+ ETLRL Sbjct: 313 ETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRL 372 Query: 541 YSPALFMQRKTVADMTVGS---LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 Y+ ++RK + D V L + KG ++IP HRD++++ + + F P RF Sbjct: 373 YTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLY-PNPETFDPERFSPE 431 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 AA+ L F GPR+CIG F ++A+ LA ++ +F Sbjct: 432 KV-AARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRF 472
>CP120_SYNY3 (Q59990) Putative cytochrome P450 120 (EC 1.14.-.-)| Length = 444 Score = 68.9 bits (167), Expect = 1e-11 Identities = 54/189 (28%), Positives = 84/189 (44%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE + L+ LL + + +ER+R+E K Q L K+ + VL E LRL Sbjct: 256 HETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQELTAETLKKMPYLDQVLQEVLRLI 315 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 P R+ + D PKG + I H D +++ D ++F P RF + Sbjct: 316 PPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLY-PDPEKFDPERFTPDGSAT 374 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKF 179 P + F G R C+G+ F+ LE K ++Q+F +TL P V + +PK Sbjct: 375 HNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKD 434 Query: 178 GLQVFVRPL 152 L+V + L Sbjct: 435 NLRVKLHSL 443
>C82A3_SOYBN (O49858) Cytochrome P450 82A3 (EC 1.14.-.-) (P450 CP6)| Length = 527 Score = 68.9 bits (167), Expect = 1e-11 Identities = 60/201 (29%), Positives = 93/201 (46%), Gaps = 9/201 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA-LNKLKEMTMVLFETLRLY 539 ++T++ LTW++ LL P + ++E+ + G + ++KL + ++ ETLRLY Sbjct: 326 DSTAVTLTWALSLLLRNPLALGKAKEEIDMQIGKDEYIRESDISKLVYLQAIVKETLRLY 385 Query: 538 SPALFMQ-RKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 PA F R+ + +G + KG ++ + +HRD VW D EFKP RF Sbjct: 386 PPAPFSSPREFTENCILGGYHIKKGTRLIHNLWKIHRDPSVWSDPL-EFKPERFLTTHKD 444 Query: 361 AAKVPHG--LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI---- 200 H LL F G R C G + + TLA +L F L+P PVD+ Sbjct: 445 VDLRGHNFELLPFGSGRRVCAGMSLGLNMVHFTLANLLHSFDI-LNPS--AEPVDMTEFF 501 Query: 199 -FTLKPKFGLQVFVRPLDKCN 140 FT L++ V+P N Sbjct: 502 GFTNTKATPLEILVKPRQSPN 522
>CP52L_DEBHA (Q9Y757) Cytochrome P450 52A12 (EC 1.14.14.-) (Alkane hydroxylase| 1) (Alkane-inducible p450alk 1) (DH-ALK2) Length = 519 Score = 68.9 bits (167), Expect = 1e-11 Identities = 51/184 (27%), Positives = 91/184 (49%), Gaps = 15/184 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG------MQSPDPNALNKLKEMTMVLFE 554 + T+ LL+++ Y L+ P+ +L++E+ ++FG ++ +L K + + +L E Sbjct: 319 DTTAGLLSFTFYELARNPQVWLKLKEEIYEKFGKGDDARLEDITFESLKKCEYLKALLNE 378 Query: 553 TLRLYS--PALFMQRKTVADMTVGS-------LKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 LRLY P F + + G + + KG + + MHRD++ +G D++ Sbjct: 379 VLRLYPSVPQNFRVAQKDTSLPRGGGPNRDQPIFIAKGQTVTYTVYAMHRDEQFYGKDSE 438 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 F+P R+ T K+ L F+ GPR C+GQ F++ EA +A + Q F S D Sbjct: 439 VFRPERWFEPET--RKLGWAFLPFNGGPRICLGQQFALTEASYVIARLAQLFPNLASHDD 496 Query: 220 VHAP 209 + P Sbjct: 497 EYPP 500
>CP17A_SHEEP (Q29497) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 68.9 bits (167), Expect = 1e-11 Identities = 45/168 (26%), Positives = 86/168 (51%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L +P ++R++ + + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVIKWIVAYLLHHPSLKKRIQDSIDQNIGFNRTPTISDRNRLVLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K + D ++G L + KG +V+ + +H +++ W D F P RF + TG Sbjct: 365 PVAPMLIPHKAIIDSSIGDLTIDKGTDVVVNLWALHHNEKEW-QQPDLFMPERFLDP-TG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSC+G+ + E ++ +LQ+F+ + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDD 470
>CP52A_CANTR (P10615) Cytochrome P450 52A1 (EC 1.14.14.-) (CYPLIIA1)| (Alkane-inducible P450-ALK1) Length = 543 Score = 68.9 bits (167), Expect = 1e-11 Identities = 49/172 (28%), Positives = 84/172 (48%), Gaps = 15/172 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM------QSPDPNALNKLKEMTMVLFE 554 + T+ LL++ + LS PE +LR+E+ +FG+ + L + + V+ E Sbjct: 339 DTTAGLLSFLFFELSRNPEIFAKLREEIENKFGLGQDARVEEISFETLKSCEYLKAVINE 398 Query: 553 TLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 TLR+Y R + T+ + + KG ++ I HRDK+++G+DA Sbjct: 399 TLRIYPSVPHNFRVATRNTTLPRGGGEGGLSPIAIKKGQVVMYTILATHRDKDIYGEDAY 458 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 F+P R+ T K+ + F+ GPR C+GQ F++ EA +LQ+F Sbjct: 459 VFRPERWFEPET--RKLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEF 508
>C86A2_ARATH (O23066) Cytochrome P450 86A2 (EC 1.14.-.-)| Length = 553 Score = 68.6 bits (166), Expect = 2e-11 Identities = 56/205 (27%), Positives = 100/205 (48%), Gaps = 16/205 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLK--------EFGMQSPDP---NALNKLKEMT 569 + +S+ L+W +L++ +P ++++ +E+ + + +P + +++L + Sbjct: 310 DTSSVALSWFFWLITTHPTVEDKIVREICSVLIETRGTDVSSWTAEPLEFDEVDRLVYLK 369 Query: 568 MVLFETLRLYSPALFMQRKTVA--DMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEF 395 L ETLRLY P++ K V D+ +P G ++ I R K WG+D EF Sbjct: 370 AALSETLRLY-PSVPEDSKHVVNDDILPDGTFVPAGSSVTYSIYAAGRMKSTWGEDCLEF 428 Query: 394 KPLRFKNGITGAAKVPHG---LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 KP R+ + G V H +AF+ GPR C+G++ + L+ K+ A +L + T++P Sbjct: 429 KPERWISPDDGKF-VNHDQYRFVAFNAGPRICLGKDLAYLQMKTIAAAVLLRHRLTVAPG 487 Query: 223 YVHAPVDIFTLKPKFGLQVFVRPLD 149 + TL K GL V V D Sbjct: 488 HKVEQKMSLTLFMKNGLLVNVHKRD 512
>CP6D4_DROME (Q9VCW1) Probable cytochrome P450 6d4 (EC 1.14.-.-) (CYPVID4)| Length = 515 Score = 68.6 bits (166), Expect = 2e-11 Identities = 55/190 (28%), Positives = 88/190 (46%), Gaps = 7/190 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEV----LKEFGMQSPDPNALNKLKEMTMVLFETL 548 E T +++Y L+ YPE +RL+ EV K G + D +LNK++ + + + ET+ Sbjct: 321 ETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYD--SLNKMEFLDLCVQETI 378 Query: 547 RLYSPALFMQRKTVADMTVGSLK--LPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 R Y + R+ D TV +PKG +VI + +H D E + D + + P RF Sbjct: 379 RKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYF-PDPETYDPERFSE 437 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF-TLSPDYVHAPVDIF 197 P + F GPR CI Q + +K + +LQ F+ +S + Sbjct: 438 ESRNYN--PTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGI 495 Query: 196 TLKPKFGLQV 167 L PK G++V Sbjct: 496 ALIPKHGVRV 505
>CP6G2_DROME (Q9V675) Probable cytochrome P450 6g2 (EC 1.14.-.-) (CYPVIG2)| Length = 519 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 9/176 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETLR 545 E++S + +++Y L+ + Q+RLR+E+ L E G Q + L+ M M+L E LR Sbjct: 319 ESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVT-LKMIESLEFMQMILLEVLR 377 Query: 544 LYSPALFMQRKTVADMTVG------SLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 +Y P F+ R+ + +PKG+ + IP +H D + + +F P R Sbjct: 378 MYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPR-KFLPER 436 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVH 215 F P+ + F +GP CIG+ F L+AK L +L+ T S H Sbjct: 437 FSPE-NRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPH 491
>C4AA1_DROME (Q9V7G5) Probable cytochrome P450 4aa1 (EC 1.14.-.-) (CYPIVAA1)| Length = 514 Score = 68.6 bits (166), Expect = 2e-11 Identities = 44/159 (27%), Positives = 82/159 (51%), Gaps = 2/159 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQER--LRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRL 542 ++ + ++++LL+ PE Q+R L + E ++P L++++ M M + E LRL Sbjct: 319 DSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRL 378 Query: 541 YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 Y + RK ++ + LP G + I HR ++ D ++F+P RF Sbjct: 379 YPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIY-PDPEKFQPERFSPE-NS 436 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P+ L FS GPR CIG F+++E K+ ++ +L+ + Sbjct: 437 ENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSY 475
>CP27A_MOUSE (Q9DBG1) Cytochrome P450 27, mitochondrial precursor (EC| 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) Length = 533 Score = 68.6 bits (166), Expect = 2e-11 Identities = 54/169 (31%), Positives = 81/169 (47%), Gaps = 6/169 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEV--LKEFGMQSPDPNALNKLKEMTMVLFETLRL 542 + TS LTW++Y LS PE QE L KEV + FG + P + + V+ ETLRL Sbjct: 340 DTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFG-KVPQHKDFAHMPLLKAVIKETLRL 398 Query: 541 YSPALFMQRK-TVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKP---LRFKN 374 Y R T + + PK V+ ++ RD V+ + + F+P LR K Sbjct: 399 YPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVF-PEPNSFQPHRWLRKKE 457 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 P G + F G RSC+G+ + LE + L+ ++QK+ L+P Sbjct: 458 ADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAP 506
>C71A8_MENPI (Q42716) Cytochrome P450 71A8 (EC 1.14.-.-)| Length = 502 Score = 68.6 bits (166), Expect = 2e-11 Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 2/163 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF-GMQSPDPNALNKLKEMTMVLFETLRLY 539 + T+++L W++ L +PE ++L+ EV + + + + K+ + V+ ET+R + Sbjct: 311 DTTAVVLEWAMTELLRHPEIMKKLQSEVRQVVKDKHNITDDDIEKMHYLKAVMKETMRFH 370 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 +P L + R D+ V +P G ++I + RD W D+ ++F+P RF N Sbjct: 371 TPIPLLVPRVARNDVEVMGYDVPVGTMVMINAWAIGRDPTSW-DEPEKFRPERFLNSSVD 429 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 + L+ F G R C G F M + TLA ++QKF + L Sbjct: 430 FKGLDFELIPFGAGRRGCPGTTFPMATLEFTLANLMQKFDWEL 472
>CP6D1_MUSDO (Q27698) Cytochrome P450 6d1 (EC 1.14.-.-) (CYPVID1) (Pyrethroid| resistance cytochrome P450) (Cytochrome P450 Ipr) Length = 516 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/171 (28%), Positives = 82/171 (47%), Gaps = 8/171 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDP---NALNKLKEMTMVLFE 554 E T+ ++++Y L++YPE ++ + EV L+ G++ A+ +K + + + E Sbjct: 321 ETTAATTSFTIYELAMYPEILKKAQSEVDECLQRHGLKPQGRLTYEAIQDMKYLDLCVME 380 Query: 553 TLRLYSPALFMQRKTVADMTVGSLKL--PKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF 380 T R Y F+ RK D V KL PK I+I + +HRD + + D ++P RF Sbjct: 381 TTRKYPGLPFLNRKCTQDFQVPDTKLTIPKETGIIISLLGIHRDPQYFPQPED-YRPERF 439 Query: 379 KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 + P + F GPR CI Q ++ +K LA +L F+ P Sbjct: 440 AD--ESKDYDPAAYMPFGEGPRHCIAQRMGVMNSKVALAKILANFNIQPMP 488
>C71AM_ARATH (Q9STL1) Cytochrome P450 71A22 (EC 1.14.-.-)| Length = 490 Score = 68.6 bits (166), Expect = 2e-11 Identities = 43/169 (25%), Positives = 83/169 (49%), Gaps = 2/169 (1%) Frame = -3 Query: 700 LLTWSVYLLSIYPEWQERLRKEVLKEF-GMQSPDPNALNKLKEMTMVLFETLRLYSPA-L 527 L+ W++ L PE RL++EV G S + + + + V+ ET+RL+ P L Sbjct: 300 LMEWAMTELLHRPECLNRLQEEVRTICKGNSSVSEDDIKDMNYLKAVIKETMRLHPPLPL 359 Query: 526 FMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAKVP 347 + ++ D+ +G +P G ++I + R+ WG DA++F+P R N Sbjct: 360 MVPHESTQDVRLGDYHIPAGTQVMINAWAIGREAATWGPDAEKFRPERHLNSSVDFRGHN 419 Query: 346 HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI 200 L+ F G R C +F+++ + TLA ++ ++ + L +Y+ ++ Sbjct: 420 FELIPFGAGRRICPAISFAVILIEVTLANLVHRYDWRLPEEYIEDQTNV 468
>CP313_DROME (Q9VHP4) Probable cytochrome P450 313b1 (EC 1.14.-.-)| (CYPCCCXIIIB1) Length = 502 Score = 68.2 bits (165), Expect = 2e-11 Identities = 48/163 (29%), Positives = 82/163 (50%), Gaps = 6/163 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA--LNKLKEMTMVLFETLRL 542 E TS L +++ L+++P +QE+L KE++ E S D N L +L+ MV+ E +RL Sbjct: 310 ETTSTALYFTILCLAMHPCYQEKLHKELVTELP-PSGDINLEQLQRLEYTEMVINEAMRL 368 Query: 541 YSPALFMQRKTVADMTV----GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN 374 ++P + R D+ + G +P+G I I I M RD+ VWG + + P Sbjct: 369 FAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNP-DAHF 427 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 G+ + + F+ G R CIG ++ + K LA + + + Sbjct: 428 GLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSY 470
>CPXN_ANASP (P29980) Probable cytochrome P450 110 (EC 1.14.-.-)| Length = 459 Score = 68.2 bits (165), Expect = 2e-11 Identities = 54/192 (28%), Positives = 95/192 (49%), Gaps = 6/192 (3%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 HE T+ + W+ Y + QE+L++E L G +P+P + +L +T V ETLR+Y Sbjct: 263 HETTATTIAWAFYQILKNVNVQEKLQQE-LDRLG-ANPNPMEIAQLPYLTAVSQETLRMY 320 Query: 538 S--PALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 P LF R T + + + +L ++ I ++H ++++ + +F+P RF Sbjct: 321 PVLPTLF-PRITKSSINIAGYQLEPDTTLMASIYLIHYREDLY-PNPQQFRPERF----I 374 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI----F 197 P + F G R C+G ++LE K +A +L + L+ D PV++ F Sbjct: 375 ERQYSPSEYIPFGGGSRRCLGYALALLEIKLVIATVLSNYQLALAED---KPVNVQRRGF 431 Query: 196 TLKPKFGLQVFV 161 TL P G++V + Sbjct: 432 TLAPDGGVRVIM 443
>C4AC3_DROME (Q9VMS7) Probable cytochrome P450 4ac3 (EC 1.14.-.-) (CYPIVAC3)| Length = 509 Score = 67.8 bits (164), Expect = 3e-11 Identities = 51/162 (31%), Positives = 85/162 (52%), Gaps = 4/162 (2%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEV--LKEFGMQSPDPNALNKLKEMTMVLFETLR 545 ++ TS L +++ LL+++ + QER +E+ L E + N+L + V+ E+LR Sbjct: 319 YDTTSTSLIFTLLLLALHADVQERCYEELQDLPE-DIDEVSMFQFNELIHLECVIKESLR 377 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KNG 371 L+ A + R + + + L LPK I I I + RD + ++F P RF +N Sbjct: 378 LFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHF-PKPNQFLPERFLPENS 436 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + + P + FS GPR+CIGQ F +LE K LA +++ F Sbjct: 437 VN---RHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNF 475
>C71AO_ARATH (Q9STK9) Cytochrome P450 71A24 (EC 1.14.-.-)| Length = 486 Score = 67.8 bits (164), Expect = 3e-11 Identities = 48/177 (27%), Positives = 85/177 (48%), Gaps = 5/177 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLK----EFGMQSPDPNALNKLKEMTMVLFETL 548 + T LL W++ L + E +RL++EV + G+ D L +K + V+ ETL Sbjct: 294 DTTYTLLEWAMTELLCHHECLDRLQEEVRMVCKDKSGVSEDD---LQDMKYLKAVIKETL 350 Query: 547 RLYSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG 371 RL+ P L + ++ D+ + +P G ++I + R+ WG DA+EF+P R N Sbjct: 351 RLHPPLPLMVPHESTHDVKLRDYHIPAGTHVMINAWAIGREAATWGPDAEEFRPERHLNS 410 Query: 370 ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI 200 L+ F G R C +F+++ + LA ++ +F +TL + D+ Sbjct: 411 YVDYRGQDTELVPFGAGRRICPAISFAVVLDEVVLANLVHQFDWTLPEESTEYQTDV 467
>CP17A_PANTR (Q8HYN1) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/167 (27%), Positives = 83/167 (49%), Gaps = 3/167 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W++ L P+ +++L +E+ + G ++P + N+L + + E LRL Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + KG ++I + +H +++ W D+F P RF N Sbjct: 365 PVAPMLIPHKANVDSSIGEFAVDKGTQVIINLWALHHNEKEW-HQPDQFMPERFLNPAGT 423 Query: 361 AAKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 P L F GPRSCIG+ + E +A +LQ+F + D Sbjct: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
>CP17A_HUMAN (P05093) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-monooxygenase) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/167 (27%), Positives = 83/167 (49%), Gaps = 3/167 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W++ L P+ +++L +E+ + G ++P + N+L + + E LRL Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + KG ++I + +H +++ W D+F P RF N Sbjct: 365 PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW-HQPDQFMPERFLNPAGT 423 Query: 361 AAKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 P L F GPRSCIG+ + E +A +LQ+F + D Sbjct: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
>CP17A_CAVPO (Q64410) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 67.8 bits (164), Expect = 3e-11 Identities = 50/195 (25%), Positives = 93/195 (47%), Gaps = 8/195 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E +S ++ W + L P+ ++++++E+ G ++P + N L + + E LR+ Sbjct: 305 ETSSSVVLWVIAFLLHNPQVKKKIQEEIDHNVGFSRTPTFSDRNHLLMLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + K +++ + +H +++ W D D+F P RF + Sbjct: 365 PVAPILIPHKANTDSSIGEFAIDKDTNVLVNLWALHHNEQEW-DRPDQFMPERFLDPTGS 423 Query: 361 AAKVPHG-LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLS-----PDYVHAPVDI 200 VP L F GPRSC+G+ + E A +LQKF + P P + Sbjct: 424 QIIVPSSSYLPFGAGPRSCVGEALARQEIFLITAWLLQKFDLEVPEGGQLPSLEGIPKIV 483 Query: 199 FTLKPKFGLQVFVRP 155 F + P F +++ VRP Sbjct: 484 FLIDP-FKVKITVRP 497
>CP1A2_BALAC (Q3LFT9) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 67.4 bits (163), Expect = 4e-11 Identities = 52/187 (27%), Positives = 93/187 (49%), Gaps = 4/187 (2%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLYSPALF- 524 ++WS+ L PE Q ++++E+ G + P + ++L + + ET R S F Sbjct: 325 ISWSLLYLVTNPEIQRKIQQELDTVIGRARRPRLSDRSQLPYLEAFILETFRHSSFVPFT 384 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KNGITGAAKV 350 + T+ D T+ +PK + + I ++ D ++WGD + EF+P RF + T + + Sbjct: 385 IPHSTIRDTTLNGFYIPKELCVFINQWQVNHDPKLWGDPS-EFRPERFLTSHDTTISKTL 443 Query: 349 PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKFGLQ 170 ++ F MG R CIG+ + E LA++LQ+ F++ P VD L P +GL Sbjct: 444 SEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG---VKVD---LTPTYGLT 497 Query: 169 VFVRPLD 149 + P + Sbjct: 498 MKPAPCE 504
>CP6A8_DROME (Q27593) Cytochrome P450 6a8 (EC 1.14.-.-) (CYPVIA8)| Length = 506 Score = 67.4 bits (163), Expect = 4e-11 Identities = 50/167 (29%), Positives = 84/167 (50%), Gaps = 7/167 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN----ALNKLKEMTMVLFETL 548 E +S + +++Y L+ P+ Q+++R EV E ++ D N LK + VL ETL Sbjct: 313 ETSSSTMGFALYELAKNPDIQDKVRAEV--EEVIEQHDQNFTYECTKDLKYLNQVLDETL 370 Query: 547 RLYSPALFMQRKTVADMTVG---SLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK 377 RLY+ + R V + + G +++IP +H D ++ + EF+P RF Sbjct: 371 RLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPF-EFRPERFS 429 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFT 236 A + L F GPR+CIG F ++A+ LAL+++ F F+ Sbjct: 430 PE-ESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFS 475
>CP11A_ONCMY (Q07217) Cytochrome P450 11A1, mitochondrial precursor (EC| 1.14.15.6) (CYPXIA1) (P450(SCC)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase) Length = 514 Score = 67.4 bits (163), Expect = 4e-11 Identities = 54/192 (28%), Positives = 94/192 (48%), Gaps = 4/192 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMV---LFETLR 545 + TS+ L W++Y L+ +P+ QE LR EV QS + L LK + +V L ETLR Sbjct: 327 DTTSITLLWTLYELARHPDLQEELRAEVA--VARQSTQGDMLQMLKMIPLVKGALKETLR 384 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 L+ A+ +QR ++ + + +P G + + + M RD +V+ +++ P R+ Sbjct: 385 LHPVAVSLQRYITEEIVIQNYHIPCGTLVQLGLYAMGRDPDVF-PRPEKYLPSRWLR--- 440 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY-VHAPVDIFTLK 188 L F GPR C+G+ + E + L ML+ F VH+ ++ L Sbjct: 441 -TENQYFRSLGFGFGPRQCLGRRIAETEMQLFLIHMLENFRVDKQRQVEVHSTFELILL- 498 Query: 187 PKFGLQVFVRPL 152 P+ + + ++PL Sbjct: 499 PEKPILLTLKPL 510
>CP1A1_RAT (P00185) Cytochrome P450 1A1 (EC 1.14.14.1) (CYP1A1) (CYPIA1)| (P450-C) (P450MT2) [Contains: Cytochrome P450MT2A; Cytochrome P450MT2B] Length = 524 Score = 67.4 bits (163), Expect = 4e-11 Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLYSPALF- 524 ++WS+ L P Q ++++E+ G + P + +L + + ET R S F Sbjct: 330 ISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFT 389 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAK-VP 347 + T+ D ++ +PKG + + ++ D+E+WGD +EF+P RF K + Sbjct: 390 IPHSTIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDP-NEFRPERFLTSSGTLDKHLS 448 Query: 346 HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 ++ F +G R CIG+ LE LA++LQ+ F +SP Sbjct: 449 EKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSP 488
>CP308_DROME (Q9VWR2) Probable cytochrome P450 308a1 (EC 1.14.-.-)| (CYPCCCVIIIA1) Length = 490 Score = 67.4 bits (163), Expect = 4e-11 Identities = 51/178 (28%), Positives = 87/178 (48%), Gaps = 13/178 (7%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLR---KEVLKEFGMQSPDPNALNKLKEMTMVLFETL 548 +E +++LL +++Y L++ + Q RL EV + DP AL +L+ L E L Sbjct: 289 YETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAALLEAL 348 Query: 547 RLYSPALFMQRK-----TVADMTVGS---LKLPKGIAIVIPIPIMHRDKEVWGDDADEFK 392 RL+ +Q++ T+ D G+ LK+ G +V+P+ +H D ++ ++F+ Sbjct: 349 RLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALY-PAPNQFR 407 Query: 391 PLRFKNGITGAAKVPHG--LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 P RF N + P G L F GPR C G +L+ K+ L +LQ L+ + Sbjct: 408 PERFLN------QPPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADE 459
>C4AD1_DROME (Q9V4T3) Probable cytochrome P450 4ad1 (EC 1.14.-.-) (CYPIVAD1)| Length = 516 Score = 67.4 bits (163), Expect = 4e-11 Identities = 46/173 (26%), Positives = 88/173 (50%), Gaps = 8/173 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ---SPDPNALNKLKEMTMVLFETL 548 H+ + +++++Y LS + E Q++ +E + FG D L+++ + +++ ETL Sbjct: 307 HDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETL 366 Query: 547 RLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN-- 374 RLY + R + + K+ K +++ + M +++ + DD F+P RF+N Sbjct: 367 RLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYF-DDPCTFRPERFENPT 425 Query: 373 ---GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 GI VP FS GPR CI + F+M + K+ L+ +L++F + D Sbjct: 426 GNVGIEAFKSVP-----FSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVD 473
>CP17A_CAPHI (Q9N0U7) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 67.0 bits (162), Expect = 6e-11 Identities = 45/168 (26%), Positives = 85/168 (50%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L +P ++R++ + + G ++P + N L + + E LR+ Sbjct: 305 ETTTSVIKWIVAYLLHHPSLKKRIQDSIDQNIGFNRTPTISDRNCLVLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K + D ++G L + KG +V+ + +H +++ W D F P RF + TG Sbjct: 365 PVAPMLIPHKAIIDSSIGDLTIDKGTDVVVNLWALHHNEKEW-QQPDLFMPERFLDP-TG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSC+G+ + E ++ +LQ+F+ + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDD 470
>CP17A_BOVIN (P05185) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 67.0 bits (162), Expect = 6e-11 Identities = 46/168 (27%), Positives = 85/168 (50%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L +P ++R++ ++ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + K V D ++G L + KG +V+ + +H ++ W D F P RF + TG Sbjct: 365 PVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEW-QHPDLFMPERFLDP-TG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSC+G+ + E ++ +LQ+F+ + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDD 470
>CP17A_PAPCY (Q8HYN0) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 67.0 bits (162), Expect = 6e-11 Identities = 47/168 (27%), Positives = 84/168 (50%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L P+ +++L +E+ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + KG ++I + +H +++ W D+F P RF N G Sbjct: 365 PVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEW-HQPDQFMPERFLNP-AG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSCIG+ + E +A +LQ+F + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
>CP17A_MACMU (Q8HYM9) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 67.0 bits (162), Expect = 6e-11 Identities = 47/168 (27%), Positives = 84/168 (50%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L P+ +++L +E+ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + KG ++I + +H +++ W D+F P RF N G Sbjct: 365 PVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEW-HQPDQFMPERFLNP-AG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSCIG+ + E +A +LQ+F + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
>CP17A_MACFA (Q2XVA1) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 67.0 bits (162), Expect = 6e-11 Identities = 47/168 (27%), Positives = 84/168 (50%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L P+ +++L +E+ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + KG ++I + +H +++ W D+F P RF N G Sbjct: 365 PVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEW-HQPDQFMPERFLNP-AG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSCIG+ + E +A +LQ+F + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
>CP2J5_MOUSE (O54749) Cytochrome P450 2J5 (EC 1.14.14.1) (CYPIIJ5) (Arachidonic| acid epoxygenase) Length = 501 Score = 67.0 bits (162), Expect = 6e-11 Identities = 46/161 (28%), Positives = 73/161 (45%), Gaps = 2/161 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRLY 539 E TS L W++ +S YPE QE ++ E+ + G + + + V+ E R+ Sbjct: 313 ETTSSTLRWALLYMSSYPEIQENVQAEIDRVIGHKRQVSLSDRESMPYTNAVIHEVQRMG 372 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + L R+ D LPKG I+ + +HRD + W + F P F G Sbjct: 373 NIVPLNSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATP-EVFNPEHFLEN--G 429 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 K L FSMG R+C+G+ + E + ++QKF+F Sbjct: 430 QFKKRESFLPFSMGKRACLGEQLAKSELFIFFSALMQKFTF 470
>CP2L1_PANAR (Q27712) Cytochrome P450 2L1 (EC 1.14.14.1) (CYPIIL1)| Length = 492 Score = 67.0 bits (162), Expect = 6e-11 Identities = 46/162 (28%), Positives = 79/162 (48%), Gaps = 2/162 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRLY 539 E TS ++ W++ L YPE Q ++++E+ + P +KL + E R+ Sbjct: 301 ETTSTMIRWTILYLMKYPEVQAKIQREIDAAVPRGTLPSLEHKDKLAYFEATIHEVHRIV 360 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 S L + T D + +LPKG ++ + HRD W + +EF P F + Sbjct: 361 SLVPLGVSHYTNQDTELAGYRLPKGTVVMSHLECCHRDPSYW-EKPNEFYPEHFLDDQGK 419 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFT 236 K H L+ FS+G R C+G++ + +E L+ +LQ F+F+ Sbjct: 420 FVKREH-LVNFSVGRRVCVGESLARMELFVFLSAILQNFTFS 460
>KO1_ARATH (Q93ZB2) Ent-kaurene oxidase (EC 1.14.13.78) (AtKO1) (Cytochrome| P450 701A3) Length = 509 Score = 66.6 bits (161), Expect = 7e-11 Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 2/162 (1%) Frame = -3 Query: 712 NTSLLLT-WSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 +T+L+ T W++Y L+ +P Q+RL KE+ G + L+++ + V ETLR YS Sbjct: 319 DTTLVTTEWAIYELAKHPSVQDRLCKEIQNVCGGEKFKEEQLSQVPYLNGVFHETLRKYS 378 Query: 535 PA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 PA L R D +G +P G I I I + DK+ W + +++ P RF + Sbjct: 379 PAPLVPIRYAHEDTQIGGYHVPAGSEIAINIYGCNMDKKRW-ERPEDWWPERFLDDGKYE 437 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 H +AF G R C G + L A + ++Q+F + L Sbjct: 438 TSDLHKTMAFGAGKRVCAGALQASLMAGIAIGRLVQEFEWKL 479
>CP17A_BISBI (Q9GMC7) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 66.6 bits (161), Expect = 7e-11 Identities = 46/168 (27%), Positives = 85/168 (50%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L +P ++R++ ++ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPAISDRNRLVLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + K V D ++G L + KG +V+ + +H ++ W D F P RF + TG Sbjct: 365 PVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEW-QHPDLFMPERFLDP-TG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSC+G+ + E ++ +LQ+F+ + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDD 470
>CP2D1_RAT (P10633) Cytochrome P450 2D1 (EC 1.14.14.1) (CYPIID1) (P450-DB1)| (P450-CMF1A) (P450-UT-7) (Debrisoquine 4-hydroxylase) Length = 504 Score = 66.6 bits (161), Expect = 7e-11 Identities = 44/161 (27%), Positives = 81/161 (50%), Gaps = 2/161 (1%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRLYSP 533 T+ LTW++ L+ +YP+ Q R+++E+ + G ++ P+ + V+ E R Sbjct: 313 TATTLTWALLLMILYPDVQRRVQQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDI 372 Query: 532 A-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAA 356 A L + R T D+ V +PKG ++I + + +D+ VW + F P F + Sbjct: 373 APLNLPRFTSCDIEVQDFVIPKGTTLIINLSSVLKDETVW-EKPHRFHPEHFLDAQGNFV 431 Query: 355 KVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 K + FS G R+C+G+ + +E +LQ+FSF++ Sbjct: 432 K-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV 471
>CP17A_ONCMY (P30437) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 514 Score = 66.6 bits (161), Expect = 7e-11 Identities = 51/184 (27%), Positives = 91/184 (49%), Gaps = 3/184 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E TS +L W++ L +P+ Q+R+++E+ G ++P + L + + E LR+ Sbjct: 312 ETTSTVLKWAIAYLIHHPQVQQRIQEELDSVVGGDRTPQLSDRGSLPYLEATIREVLRIR 371 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI-T 365 A L + D ++G + KG I+I + +H D++ W + + F P RF N T Sbjct: 372 PVAPLLIPHVAQTDTSIGKFTVRKGARIIINLWSLHHDEKEW-KNPEMFDPGRFLNEEGT 430 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 G L F G R C+G+ + +E L+ +LQ+ + T+SP + +L+ Sbjct: 431 GLCIPSPSYLPFGAGVRVCLGEALAKMEIFLFLSWILQRLTMTVSPGQ-----PLPSLEG 485 Query: 184 KFGL 173 KFG+ Sbjct: 486 KFGV 489
>CP1A1_CHACA (Q92039) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 66.2 bits (160), Expect = 9e-11 Identities = 51/185 (27%), Positives = 87/185 (47%), Gaps = 4/185 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + S L+WSV L YP+ QERL +E+ G+ ++P + +K+ + + E R Sbjct: 325 DTVSTALSWSVMYLVAYPDIQERLFQEIKDNVGLDRTPLLSDRSKVPYLEAFILELFRHS 384 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK--NGI 368 S F + + D ++ +PK + I ++RD E+W D F P RF NG Sbjct: 385 SFLPFTIPHCSAKDTSLNGYFIPKDTCVFINQWQINRDPELW-KDPSSFNPDRFLSCNGT 443 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 + ++ F MG R CIG+ + E LA+++Q+ F P ++ + Sbjct: 444 EVNKQEGEKVMVFGMGKRRCIGEVIARNEVYRGLAILIQRLQFH------EMPGELLDMT 497 Query: 187 PKFGL 173 P++GL Sbjct: 498 PEYGL 502
>CP9B2_DROME (Q9V4I1) Cytochrome P450 9b2 (EC 1.14.-.-) (CYPIXB2)| Length = 505 Score = 66.2 bits (160), Expect = 9e-11 Identities = 52/172 (30%), Positives = 82/172 (47%), Gaps = 9/172 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP---NALNKLKEMTMVLFETLR 545 EN S L+ + Y L P+ QERL +E+++ + P +A+ K+ M MV+ E+LR Sbjct: 307 ENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLR 366 Query: 544 LYSPALFMQRKTVADMTVGS------LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 ++ A R D T+ G I IPI +H D + + +F P R Sbjct: 367 KWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPR-KFDPDR 425 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 F G VP+ L F +GPR+CIG +++++ K L +L + SP Sbjct: 426 FSEERKGDM-VPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASP 476
>CP6G1_DROME (Q9V674) Cytochrome P450 6g1 (EC 1.14.-.-) (CYPVIG1) (Cyp6-like| protein) Length = 524 Score = 66.2 bits (160), Expect = 9e-11 Identities = 52/172 (30%), Positives = 83/172 (48%), Gaps = 14/172 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF--GMQSPDPNALNKLKEMTMVLFETLRL 542 E +S +++++Y ++ +PE Q+RLR E+ + G S + L+ + MV+ E LR+ Sbjct: 315 ETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRM 374 Query: 541 YSPALFMQRK--TVADMTVGSLK------LPKGIAIVIPIPIMHRDKEVWGD----DADE 398 Y F+ R+ +V SLK L G + IPI +H D + W + D + Sbjct: 375 YPVLPFLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPER 434 Query: 397 FKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 F P KN I A P F GP +CIG +L++K L +L+ S Sbjct: 435 FSPANRKN-IVAMAYQP-----FGSGPHNCIGSRIGLLQSKLGLVSLLKNHS 480
>CP52M_DEBHA (Q9Y758) Cytochrome P450 52A13 (EC 1.14.14.-) (Alkane hydroxylase| 2) (Alkane-inducible p450alk 2) (DH-ALK2) Length = 519 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/173 (27%), Positives = 85/173 (49%), Gaps = 16/173 (9%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG------MQSPDPNALNKLKEMTMVLFE 554 + T+ LL+++ + L+ +P +L++E+ + FG + +L K + + V+ E Sbjct: 320 DTTAGLLSFTFFELARHPRVFNKLKEEIYEAFGKGDDARVSEITFESLKKCEYLKWVMNE 379 Query: 553 TLRLYSPALFMQRKTVADMTV----------GSLKLPKGIAIVIPIPIMHRDKEVWGDDA 404 LRLY P++ + + T + + KG + + HR +E +G DA Sbjct: 380 MLRLY-PSVPVNFRVATKRTTLPRGGGPDGNSPIYVGKGTTVAYSVYSTHRMEEYYGKDA 438 Query: 403 DEFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 DEFKP R+ + K+ + F+ GPR C+GQ F++ EA + +LQ F Sbjct: 439 DEFKPERWAE----SRKLGWAYVPFNGGPRICLGQQFALTEASYIVTRLLQMF 487
>CP17A_SQUAC (Q92113) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 65.9 bits (159), Expect = 1e-10 Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 4/169 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ-SPDPNALNKLKEMTMVLFETLRLY 539 E +S W + L +PE Q+++++E+ G + +P + + + + E LR+ Sbjct: 308 ETSSTAFAWMIIYLIHHPEVQKKIQEEIDSNIGFERTPKMSDKGNMNFLNATIHEILRIQ 367 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KNGI 368 + L + +AD ++G +PKG ++I + +H D++ W + D F P RF ++G Sbjct: 368 PVSPLLIPHVALADSSIGDYTIPKGTRVIINLWAIHHDEKEW-KNPDAFDPGRFLDEDG- 425 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 L F G R C+G+ + +E + +LQ+F+ + P Y Sbjct: 426 KYVCSSSESYLPFGAGTRVCLGEMLARMELFLFTSWILQRFTVQVPPGY 474
>C4AC1_DROME (Q9VMS9) Probable cytochrome P450 4ac1 (EC 1.14.-.-) (CYPIVAC1)| Length = 509 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/160 (30%), Positives = 85/160 (53%), Gaps = 2/160 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNAL--NKLKEMTMVLFETLR 545 ++ TS L +++ +L+++ + Q++ +EV + S D + NKL + V+ E+LR Sbjct: 319 YDTTSTCLIFTLLMLALHEDVQKKCYEEV-ENLPEDSDDISMFQFNKLVYLECVIKESLR 377 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 ++ F+ R+ V + V + +PK I I I + RD + D F+P RF T Sbjct: 378 MFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHF-PKPDLFQPDRFLPENT 436 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P + FS G R+CIGQ F++LE K LA +++ F Sbjct: 437 -VNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNF 475
>CP392_DROME (P82713) Probable cytochrome P450 309a2 (EC 1.14.-.-) (CYPCCCIXA2)| Length = 538 Score = 65.9 bits (159), Expect = 1e-10 Identities = 54/173 (31%), Positives = 81/173 (46%), Gaps = 8/173 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQ-SPDPNALNKLKEMTMVLFETLRL 542 ++ + L ++Y L+ P Q++LR E+L + S D L+ L+ + V++E+LRL Sbjct: 342 YDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRL 401 Query: 541 YSPALFMQRKTVADMTV-------GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 S L Q V + SL + G+ I+IP H DK+ + + + FKP R Sbjct: 402 SS--LIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYF-PEPEAFKPER 458 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 F NG L FS GPR C+G +ML KS L +L F D Sbjct: 459 FDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRD 511
>CP11A_DASAM (Q92045) Cytochrome P450 11A1, mitochondrial precursor (EC| 1.14.15.6) (CYPXIA1) (P450(SCC)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase) (Fragment) Length = 514 Score = 65.9 bits (159), Expect = 1e-10 Identities = 43/164 (26%), Positives = 77/164 (46%), Gaps = 1/164 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP-NALNKLKEMTMVLFETLRLY 539 + TS + W +Y L+ +P Q+ +R E+++ DP L + + V+ ETLRLY Sbjct: 330 DTTSTTVHWMMYELAKHPHIQKNVRSEIMEAHQKTEGDPVKMLKSVPLLKCVVKETLRLY 389 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 A+ +QR D + + +P G + + + M R+ +++ + +++ P R+ G Sbjct: 390 PVAISIQRYLNEDTVLQNYHIPAGTLVQLGLYAMGRNPKIF-KNPEQYNPERWLKG---- 444 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 L F GPR CIG+ + + + MLQ F P Sbjct: 445 EDTHFRHLGFGFGPRQCIGRRIAETQMVLLMIHMLQNFKIETDP 488
>CP1A3_ONCMY (Q92109) Cytochrome P450 1A3 (EC 1.14.14.1) (CYP1A3) (CYP1A1)| Length = 522 Score = 65.9 bits (159), Expect = 1e-10 Identities = 54/185 (29%), Positives = 87/185 (47%), Gaps = 4/185 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + S L+W+V L YPE QERL +E+ ++ GM ++P + L + + E R Sbjct: 325 DTISTALSWAVVYLVAYPETQERLHQELKEKVGMIRTPRLSDKINLPLLEAFILEIFRHS 384 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 S F + T+ D ++ +PK + I ++ D E+W + F P RF + Sbjct: 385 SFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVNHDPELW-KEPSSFNPDRFLSADGT 443 Query: 361 AAKVPHG--LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 G +L F MG R CIG+ E LA++LQ+ F P + P+D + Sbjct: 444 ELNKLEGEKVLVFGMGKRRCIGEAIGRNEVYLFLAILLQRLRFQEKPGH---PLD---MT 497 Query: 187 PKFGL 173 P++GL Sbjct: 498 PEYGL 502
>C81D1_ARATH (Q9FG65) Cytochrome P450 81D1 (EC 1.14.-.-)| Length = 502 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/161 (29%), Positives = 78/161 (48%), Gaps = 3/161 (1%) Frame = -3 Query: 712 NTSLL-LTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA-LNKLKEMTMVLFETLRLY 539 NTS + L W++ L +P+ + R E+ G+ A L++L + ++ ETLRL+ Sbjct: 309 NTSAVTLEWALSNLLNHPDVISKARDEIDNRVGLDRLIEEADLSELPYLKNIVLETLRLH 368 Query: 538 -SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 + L + D +GS +P+G +++ +HRD W DD D FKP RF+ Sbjct: 369 PATPLLVPHMASEDCKIGSYDMPRGTTLLVNAWAIHRDPNTW-DDPDSFKPERFEK---- 423 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + LLAF +G R+C G + L ++Q F + Sbjct: 424 -EEEAQKLLAFGLGRRACPGSGLAQRIVGLALGSLIQCFEW 463
>CP6T3_DROME (Q9V676) Probable cytochrome P450 6t3 (EC 1.14.-.-) (CYPVIT3)| Length = 501 Score = 65.5 bits (158), Expect = 2e-10 Identities = 50/169 (29%), Positives = 83/169 (49%), Gaps = 12/169 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEF-GMQSPDPNALNKLKEMTMVLFETLRLY 539 E +S L+ +++Y L+ P+ QERLR E+ + F + + L L + MV E LRLY Sbjct: 303 ETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLY 362 Query: 538 SPALFMQRKTVADMTVG-SLK------LPKGIAIVIPIPIMHRDKEVWGD----DADEFK 392 A F+ R+ + + G SL+ +P G+ I I +HRD+ W + D + F Sbjct: 363 PAAAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFG 422 Query: 391 PLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 P R ++ P + F GP CIG +L+ K + +L+++ Sbjct: 423 PERSRH------IHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQY 465
>CP1A1_RABIT (P05176) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450 isozyme| 6) (P-450 PHPAH1) (P450 LM6) Length = 518 Score = 65.5 bits (158), Expect = 2e-10 Identities = 47/166 (28%), Positives = 80/166 (48%), Gaps = 3/166 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + + ++WS+ L P Q ++++E+ G + P + +L + V+ ET R Sbjct: 324 DTVTTAISWSLMYLVTKPRIQRKIQEELDAVVGRARRPRFSDRPQLPYLEAVIMETFRHT 383 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 S F + T D ++G +PKG + + + D E+WGD + F+P RF Sbjct: 384 SFLPFTIPHSTTRDTSLGGFYIPKGRCVFVNQWQNNHDPELWGDP-EAFRPERFLTPSGA 442 Query: 361 AAK-VPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 K + +L F +G R CIG+ LE LA +LQ+ F++SP Sbjct: 443 VDKALTEKVLLFGLGKRKCIGETIGRLEVFLFLATLLQQVEFSVSP 488
>STCS_EMENI (Q00714) Probable sterigmatocystin biosynthesis P450 monooxygenase| stcS (EC 1.14.-.-) (Cytochrome P450 59) Length = 505 Score = 65.5 bits (158), Expect = 2e-10 Identities = 57/178 (32%), Positives = 83/178 (46%), Gaps = 13/178 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP--------DPNALNKLKEMTMVL 560 + TS L ++ YLLS +PE ++R E + FG D LN+L T VL Sbjct: 288 DTTSSTLLYAFYLLSRHPEALAKVRLEHDQVFGPYHQQVHEKIHQDAKLLNQLPYTTAVL 347 Query: 559 FETLRLYSPALFMQRK----TVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFK 392 ETLRL+ P+ M+ + D G + G + +H + W + A+ F Sbjct: 348 KETLRLFPPSASMREGGPGVEITDDN-GQVYPTAGCNVWTLTVALHHNSAHWAE-AESFI 405 Query: 391 PLRFKNGITGAAKVPHGLL-AFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDY 221 P R+ G G AF GPRSCIGQ +MLE + LA+ L++F ++P Y Sbjct: 406 PERWLVGSDHPLYPAKGAWRAFEFGPRSCIGQTLAMLELRVALAMTLREFD--IAPAY 461
>CP21A_CANFA (Q8WNW0) Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI)| (Steroid 21-hydroxylase) (21-OHase) (P450-C21) (P-450c21) Length = 492 Score = 65.1 bits (157), Expect = 2e-10 Identities = 52/171 (30%), Positives = 87/171 (50%), Gaps = 8/171 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-------MQSPDPNALNKLKEMTMVLF 557 E T+ L+W+V L +PE Q+RL++E+ +E G + DP +L ++ + Sbjct: 292 ETTATTLSWAVAFLLHHPEIQQRLQEELDRELGPGASGSRIPYRDP---TRLPLLSATVA 348 Query: 556 ETLRLYSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF 380 E LRL L + T ++ +P+G+ ++ + H D+ VW + EF+P RF Sbjct: 349 EVLRLRPVVPLALPHCTTRPSSISGYDIPEGMVVIPNLQGAHLDETVW-ERPQEFRPDRF 407 Query: 379 KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 + GA+ +LAF G R C+G+ + LE LA +L+ +FTL P Sbjct: 408 L--VPGASP---RVLAFGCGARVCLGEPLARLELLVVLAQLLR--AFTLMP 451
>CP9H1_DROME (Q9V6H1) Probable cytochrome P450 9h1 (EC 1.14.-.-) (CYPIXH1)| Length = 518 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/166 (29%), Positives = 83/166 (50%), Gaps = 9/166 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVL---KEFGMQSPDPNALNKLKEMTMVLFETLR 545 E S L + + L + P Q+RL +E++ +E Q + L K+K + MV+ E LR Sbjct: 322 EIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALR 381 Query: 544 LYSPALFMQRKTVADMTVGS------LKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLR 383 + P++ R+ D+ + KG + IPI +H D E + +D + F P R Sbjct: 382 KWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENF-EDPEFFNPER 440 Query: 382 FKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 F +G ++V + F +GPR+CIG +++E KS + +L F Sbjct: 441 FADGHALESRV---YMPFGVGPRNCIGNRMALMELKSIVYQLLLNF 483
>CP52H_CANTR (P30610) Cytochrome P450 52A8 (EC 1.14.14.-) (CYPLIIA8)| (Alkane-inducible P450-ALK5) Length = 517 Score = 65.1 bits (157), Expect = 2e-10 Identities = 53/180 (29%), Positives = 83/180 (46%), Gaps = 16/180 (8%) Frame = -3 Query: 700 LLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP------NALNKLKEMTMVLFETLRLY 539 LL+++V+ L+ P +LR++V +FG+ +L + + L ETLR+Y Sbjct: 321 LLSFAVFELARNPHIWAKLREDVESQFGLGEQSRIEEITFESLKRCGYLKAFLNETLRVY 380 Query: 538 SPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPL 386 R + T+ + + KG A+ I H D +GDDA EF+P Sbjct: 381 PSVPRNFRIATKNTTLPRGGGSDGNSPVLVKKGEAVSYGINSTHLDPVYYGDDAAEFRPE 440 Query: 385 RFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF-SFTLSPDYVHAP 209 R+ T K+ L F+ GPR C+GQ F++ EA L + Q F + L P V+ P Sbjct: 441 RWNEPST--RKLGWAYLPFNGGPRICLGQQFALTEAGYVLVRLAQSFDTLELKPPVVYPP 498
>CP4G1_DROME (Q9V3S0) Cytochrome P450 4g1 (EC 1.14.-.-) (CYPIVG1)| Length = 556 Score = 65.1 bits (157), Expect = 2e-10 Identities = 43/167 (25%), Positives = 86/167 (51%), Gaps = 9/167 (5%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG---MQSPDPNALNKLKEMTMVLFETL 548 H+ TS ++++ ++ I+ + Q ++ E FG ++ ++K + V+ ETL Sbjct: 358 HDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETL 417 Query: 547 RLYSPALFMQRKTVADMTV--GSLKLPKGIAIVIPIPIMHRDKEVWGD----DADEFKPL 386 RLY P + R+ D+ + G +PKG +++ +HR +++ + D D F P Sbjct: 418 RLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPE 477 Query: 385 RFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 R N + + + FS GPRSC+G+ ++ML+ K L+ +++ + Sbjct: 478 RMAN------RHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNY 518
>CP17A_HORSE (Q95328) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 65.1 bits (157), Expect = 2e-10 Identities = 45/168 (26%), Positives = 86/168 (51%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L P+ ++++++E+ + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVVKWIVAFLLHDPQLKKKIQEEIDQNVGFSRTPTLSDRNRLLLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K + D ++G + G ++I + +H +++ W D F P RF + TG Sbjct: 365 PVAPMLIPHKALVDSSIGEFAVDDGTNVIINLWALHHNEKEW-HQPDRFMPERFLDP-TG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + + L L F GPRSCIG+ + E A +LQ+F+ + D Sbjct: 423 SQLISPSLSYLPFGAGPRSCIGELLARQELFLFTAWLLQRFNLEVPDD 470
>C71A1_PERAE (P24465) Cytochrome P450 71A1 (EC 1.14.-.-) (CYPLXXIA1) (ARP-2)| Length = 471 Score = 64.7 bits (156), Expect = 3e-10 Identities = 44/163 (26%), Positives = 84/163 (51%), Gaps = 2/163 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRLY 539 + T++ L W++ L +P+ E+ ++EV + G ++ + L++L + +++ ETLRL+ Sbjct: 307 DTTAVTLEWAMAELIKHPDVMEKAQQEVRRVVGKKAKVEEEDLHQLHYLKLIIKETLRLH 366 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A L + R++ D+ + +P + I + RD + W ++A+EF P RF N Sbjct: 367 PVAPLLVPRESTRDVVIRGYHIPAKTRVFINAWAIGRDPKSW-ENAEEFLPERFVNNSVD 425 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 L+ F G R C G F + + +LA +L F++ L Sbjct: 426 FKGQDFQLIPFGAGRRGCPGIAFGISSVEISLANLLYWFNWEL 468
>CP2DA_RAT (P12939) Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-DB5)| (P450-CMF1B) (Debrisoquine 4-hydroxylase) Length = 504 Score = 64.7 bits (156), Expect = 3e-10 Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 6/165 (3%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRLYSP 533 T+ LTW++ L+ +YP+ Q R+++E+ + G ++ P+ + V+ E R Sbjct: 313 TATTLTWALLLMILYPDVQRRVQQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDI 372 Query: 532 A-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKN----GI 368 A L + R T D+ V +PKG ++I + + +D+ VW KPLRF Sbjct: 373 APLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWE------KPLRFHPEHFLDA 426 Query: 367 TGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 G + FS G R+C+G+ + +E +LQ FSF++ Sbjct: 427 QGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQHFSFSV 471
>C94A1_VICSA (O81117) Cytochrome P450 94A1 (EC 1.14.-.-) (P450-dependent fatty| acid omega-hydroxylase) Length = 514 Score = 64.7 bits (156), Expect = 3e-10 Identities = 48/167 (28%), Positives = 80/167 (47%), Gaps = 10/167 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMV---LFETLR 545 + TS LTW +LL P +E + E+ K+ + D ++KEM L E++R Sbjct: 318 DTTSAALTWFFWLLWKNPRVEEEIVNELSKKSELMVYD-----EVKEMVYTHAALSESMR 372 Query: 544 LYSPALFMQRKTVADMTV-GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KN 374 LY P ++ V D + + KG + + M R K +WGDD EF+P R+ K+ Sbjct: 373 LYPPVPMDSKEAVNDDVLPDGWVVKKGTIVTYHVYAMGRMKSLWGDDWAEFRPERWLEKD 432 Query: 373 GITG----AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + G + + F GPR C+G+ + ++ K +A ++ KF Sbjct: 433 EVNGKWVFVGRDSYSYPVFQAGPRVCLGKEMAFMQMKRIVAGIVGKF 479
>CP21A_BOVIN (P00191) Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI)| (Steroid 21-hydroxylase) (21-OHase) (P450-C21) (P-450c21) Length = 496 Score = 64.7 bits (156), Expect = 3e-10 Identities = 57/193 (29%), Positives = 93/193 (48%), Gaps = 6/193 (3%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNK----LKEMTMVLFETL 548 E T+ L+W+V L +PE Q RL++E+ +E G + K L + + E L Sbjct: 293 ETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVL 352 Query: 547 RLYSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-KN 374 RL L + +T ++ +P+G+ ++ + H D+ VW + EF+P RF + Sbjct: 353 RLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVW-EQPHEFRPDRFLEP 411 Query: 373 GITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFT 194 G +A LAF G R C+G++ + LE L +LQ +FTL P V A + Sbjct: 412 GANPSA------LAFGCGARVCLGESLARLELFVVLLRLLQ--AFTLLPPPVGA-LPSLQ 462 Query: 193 LKPKFGLQVFVRP 155 P G+ + V+P Sbjct: 463 PDPYCGVNLKVQP 475
>T13H_TAXCU (Q8W4T9) Taxane 13-alpha-hydroxylase (EC 1.14.13.77) (Cytochrome| P450 725A2) Length = 485 Score = 64.7 bits (156), Expect = 3e-10 Identities = 52/166 (31%), Positives = 82/166 (49%), Gaps = 7/166 (4%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP----DPNALNKLKEMT---MVL 560 +++T+ LT + +L+ +PE E++ +E +FG+ S + A LKEM V+ Sbjct: 294 YDSTNSPLTMLIKVLASHPESYEKVAQE---QFGILSTKMEGEEIAWKDLKEMKYSWQVV 350 Query: 559 FETLRLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF 380 ETLR+Y P RK + D+ +PKG + + + KE + DAD+FKP RF Sbjct: 351 QETLRMYPPIFGTFRKAITDIHYNGYTIPKGWKL-LWTTYSTQTKEEYFKDADQFKPSRF 409 Query: 379 KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 + G P+ L F G R C G F+ +E L ++ FS Sbjct: 410 EE--EGKHVTPYTYLPFGGGMRVCPGWEFAKMETLLFLHHFVKAFS 453
>C4AC2_DROME (Q9VMS8) Probable cytochrome P450 4ac2 (EC 1.14.-.-) (CYPIVAC2)| Length = 497 Score = 64.7 bits (156), Expect = 3e-10 Identities = 49/160 (30%), Positives = 85/160 (53%), Gaps = 2/160 (1%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNAL--NKLKEMTMVLFETLR 545 ++ TS L +++ +L+++ + Q++ +E+ K S D + N+L M V+ E+LR Sbjct: 306 YDTTSTCLIFTLLMLALHEDVQKKCYEEI-KYLPDDSDDISVFQFNELVYMECVIKESLR 364 Query: 544 LYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 L+ F+ R+ V + V L +PK I I + + RD + + F+P RF T Sbjct: 365 LFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPK-MFQPDRFFPENT 423 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + P + FS G R+CIGQ F++LE K LA +++ F Sbjct: 424 -VNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNF 462
>C90B1_ARATH (O64989) Cytochrome P450 90B1 (EC 1.14.-.-) (Steroid| 22-alpha-hydroxylase) (Dwarf4) (Dwarf protein 4) Length = 513 Score = 64.3 bits (155), Expect = 4e-10 Identities = 48/179 (26%), Positives = 81/179 (45%), Gaps = 14/179 (7%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVL------KEFGMQSPDPNALNKLKEMTMVLF 557 HE +S+ + +++ L P+ E LR+E L KE G + + K+ V+ Sbjct: 313 HETSSVAIALAIFFLQACPKAVEELREEHLEIARAKKELGESELNWDDYKKMDFTQCVIN 372 Query: 556 ETLRLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK 377 ETLRL + F+ RK + D+ +P G ++ I +H D + D + F P R++ Sbjct: 373 ETLRLGNVVRFLHRKALKDVRYKGYDIPSGWKVLPVISAVHLDNSRY-DQPNLFNPWRWQ 431 Query: 376 NGITGAAKVPHG--------LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 GA+ G + F GPR C G + LE + ++ KF++ L+ D Sbjct: 432 QQNNGASSSGSGSFSTWGNNYMPFGGGPRLCAGSELAKLEMAVFIHHLVLKFNWELAED 490
>CP1A1_STECH (Q92116) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 64.3 bits (155), Expect = 4e-10 Identities = 56/185 (30%), Positives = 85/185 (45%), Gaps = 4/185 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + S L+WSV L YPE QERL +E+ + G ++P + KL + + ET R Sbjct: 325 DTISTALSWSVMYLVAYPEIQERLYQEMNETVGPDRTPCLSDKPKLPFLEAFILETFRHS 384 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 S F + T D ++ +PK + I ++ D E+W D F P RF N Sbjct: 385 SFLPFTIPHCTSKDTSLNGYFIPKDTCVFINQWQINHDAELW-KDPSSFNPDRFLNADGT 443 Query: 361 AAKVPHG--LLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 G ++ F MG R CIG+ + E LA+++Q F P P+D + Sbjct: 444 EVNKLEGEKMMVFGMGKRRCIGEVIARSEVFLFLAILVQNLRFHSMPG---EPLD---MT 497 Query: 187 PKFGL 173 P++GL Sbjct: 498 PEYGL 502
>CCD1P_DROME (P82712) Probable cytochrome P450 12d1 proximal, mitochondrial| precursor (EC 1.14.-.-) (CYPXIID1) Length = 521 Score = 64.3 bits (155), Expect = 4e-10 Identities = 50/181 (27%), Positives = 87/181 (48%), Gaps = 6/181 (3%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTM---VLFETLRLY 539 T+ LL+ + LS +P+ Q +LR+E+L + N N +K+M V+ ETLR Y Sbjct: 330 TATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEEN-MKDMPYLRAVIKETLRYY 388 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 L R D+ + ++PKG +++ ++ ++ + DEF P R+ Sbjct: 389 PNGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYY-PRPDEFLPERWLRDPETG 447 Query: 358 AKV---PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 K+ P L F GPR CIG+ LE ++T+A +++ F + D +F ++ Sbjct: 448 KKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMFVME 507 Query: 187 P 185 P Sbjct: 508 P 508
>C76A2_SOLME (P37122) Cytochrome P450 76A2 (EC 1.14.-.-) (CYPLXXVIA2) (P-450EG7)| Length = 505 Score = 64.3 bits (155), Expect = 4e-10 Identities = 51/173 (29%), Positives = 79/173 (45%), Gaps = 7/173 (4%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA------LNKLKEMTMVLFE 554 E TS + W++ L +PE +++ E+ Q+ +PN + L M VL E Sbjct: 312 ETTSSSVEWALTELLRHPEAMAKVKTEI-----SQAIEPNRKFEDSDIENLPYMQAVLKE 366 Query: 553 TLRLYSPALFM-QRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFK 377 +LRL+ P F+ R+T+ D +PK +++ + RD E W DD FKP RF Sbjct: 367 SLRLHPPLPFLIPRETIQDTKFMGYDVPKDTQVLVNAWAIGRDPECW-DDPMSFKPERFL 425 Query: 376 NGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYV 218 +GL+ F G R C+G L +L++F + L PD V Sbjct: 426 GSKIDVKGQHYGLIPFGAGRRMCVGLPLGHRMMHFALGSLLREFEWEL-PDGV 477
>CP17A_PAPHU (Q9GLD2) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 64.3 bits (155), Expect = 4e-10 Identities = 46/168 (27%), Positives = 83/168 (49%), Gaps = 4/168 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 E T+ ++ W V L P+ +++L + + + G ++P + N+L + + E LR+ Sbjct: 305 ETTTSVVKWIVAFLLHNPQVKKKLYEGIDQNVGFSRTPTISDRNRLLLLEATIREVLRIR 364 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A + + K D ++G + KG ++I + +H +++ W D+F P RF N G Sbjct: 365 PVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEW-HQPDQFMPERFLNP-AG 422 Query: 361 AAKVPHGL--LAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 + L L F GPRSCIG+ + E +A +LQ+F + D Sbjct: 423 TQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
>C76A1_SOLME (P37121) Cytochrome P450 76A1 (EC 1.14.-.-) (CYPLXXVIA1) (P-450EG8)| (Fragment) Length = 467 Score = 64.3 bits (155), Expect = 4e-10 Identities = 46/163 (28%), Positives = 73/163 (44%), Gaps = 2/163 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA-LNKLKEMTMVLFETLRLY 539 E TS + W++ L +P+ +++ E+L+ G ++ L M VL E LRL+ Sbjct: 274 ETTSSSVEWALTELLRHPQAMAKVKLEILQVIGPNKKFEECDIDSLPYMQAVLKEQLRLH 333 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 P L + RK + D +PKG +++ + RD E W D+ EFKP RF Sbjct: 334 PPLPLLIPRKAIQDTKFMGYDIPKGTQVLVNAWAIGRDPEYW-DNPFEFKPERFLESKVD 392 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL 233 + L+ F G R C+G T +L +F + L Sbjct: 393 VKGQNYELIPFGAGRRMCVGLPLGHRMMHFTFGSLLHEFDWEL 435
>CP2D6_PANTR (Q2XNC8) Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6)| Length = 497 Score = 64.3 bits (155), Expect = 4e-10 Identities = 49/180 (27%), Positives = 83/180 (46%), Gaps = 5/180 (2%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRLYSP 533 TS L W + L+ ++P+ Q R+++E+ G ++ P+ ++ T V+ E R Sbjct: 310 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDI 369 Query: 532 A-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAA 356 L + T D+ V ++PKG + + + +DK VW + F P F + G Sbjct: 370 VPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVW-EKPFRFHPEHFLDA-QGHF 427 Query: 355 KVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL---SPDYVHAPVDIFTLKP 185 P L FS G R+C+G+ + +E +LQ FSF++ P H V F + P Sbjct: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTP 487
>C71AI_ARATH (Q9SAB6) Cytochrome P450 71A18 (EC 1.14.-.-)| Length = 497 Score = 64.3 bits (155), Expect = 4e-10 Identities = 45/165 (27%), Positives = 78/165 (47%), Gaps = 4/165 (2%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEV---LKEFGMQSPDPNALNKLKEMTMVLFETLRLY 539 +S LL W + L PE ++L+ E+ ++ G + N ++ + V+ E R++ Sbjct: 303 SSTLLEWIMTELIRNPECMKKLQNEIRSTIRPHGSYIKEKEVEN-MRYLKAVIKEVFRVH 361 Query: 538 SPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 P L + R D+ V + G ++I +HRD +WG DA+EFKP R + Sbjct: 362 PPLPLILPRLLTEDVKVKGYDIAAGTEVLINAWSIHRDPAIWGPDAEEFKPERHLDSTLD 421 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 + F G R C G N +M + TLA ++ +F +++ P Sbjct: 422 YHGQDLKYIPFGSGRRICPGINLAMGLVEVTLANLVGRFDWSVDP 466
>C71AE_ARATH (P58045) Cytochrome P450 71A14 (EC 1.14.-.-)| Length = 497 Score = 63.9 bits (154), Expect = 5e-10 Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 3/186 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFG--MQSPDPNALNKLKEMTMVLFETLRL 542 E T LL W + L +PE ++L+ E+ + + + +K + V+ E LRL Sbjct: 302 ETTYALLEWIMTELIRHPECMKKLQDEIRAKATKLILYISEEDVEDMKYLKAVVKEVLRL 361 Query: 541 YSPA-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 + P L + R+ D+ + + G ++I + RD WG DA+EF+P R + + Sbjct: 362 HPPLPLLVPRELSEDIKLKGYDIAAGTQVIINAWAIQRDTMTWGIDAEEFRPERHLDSLV 421 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKP 185 + F G R C G F+M + TLA ++ +F++ + V D + L Sbjct: 422 DFRGTNFEFIPFGSGRRICPGIGFAMALVEVTLANLVNRFNWRME---VQHSGDEYDLAE 478 Query: 184 KFGLQV 167 GL V Sbjct: 479 STGLDV 484
>CP1A2_RABIT (P00187) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450 isozyme| 4) (P450-PM4) (P450 LM4) Length = 515 Score = 63.9 bits (154), Expect = 5e-10 Identities = 52/179 (29%), Positives = 83/179 (46%), Gaps = 4/179 (2%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLYSPALF- 524 L+WS+ L P Q ++++E+ G + P + +L + + E R S F Sbjct: 325 LSWSLMYLVTNPRRQRKIQEELDAVVGRARQPRLSDRPQLPYLEAFILELFRHTSFVPFT 384 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAKVP- 347 + T D T+ +PK I I ++ D ++WGD +EF+P RF A P Sbjct: 385 IPHSTTRDTTLNGFHIPKECCIFINQWQINHDPQLWGDP-EEFRPERFLTADGAAINKPL 443 Query: 346 -HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKFGL 173 + F +G R CIG+ + E LA++LQ+ F++ P PVD L P +GL Sbjct: 444 SEKVTLFGLGKRRCIGETLARWEVFLFLAILLQRLEFSVPPG---VPVD---LTPIYGL 496
>CP1A2_CALJA (O77810) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 63.9 bits (154), Expect = 5e-10 Identities = 52/179 (29%), Positives = 84/179 (46%), Gaps = 4/179 (2%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLYSPALF- 524 ++WS+ L PE Q +++KE+ G + P + +L + + ET R S F Sbjct: 325 ISWSLMYLVTKPEIQRKIQKELDTVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFT 384 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAAKVP- 347 + T D T+ +PK + I ++ D ++WGD + EF+P RF A P Sbjct: 385 IPHSTTRDTTLKGFYIPKECCVFINQWQVNHDPQLWGDPS-EFRPERFLTAKGTALNKPL 443 Query: 346 -HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLKPKFGL 173 +L F +G R CIG+ E LA++LQ+ F++ P +D L P +GL Sbjct: 444 SEKILLFGLGKRRCIGEVLGKWEVFLFLAILLQQLEFSVPPG---VQID---LTPTYGL 496
>CP1A2_HUMAN (P05177) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P3)| (P(3)450) (P450 4) Length = 514 Score = 63.9 bits (154), Expect = 5e-10 Identities = 46/167 (27%), Positives = 79/167 (47%), Gaps = 4/167 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQS-PDPNALNKLKEMTMVLFETLRLY 539 + + ++WS+ L PE Q +++KE+ G + P + +L + + ET R Sbjct: 319 DTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHS 378 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 S F + T D T+ +PK + + ++ D E+W +D EF+P RF Sbjct: 379 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGT 437 Query: 361 AAKVP--HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 A P ++ F MG R CIG+ + E LA++LQ+ F++ P Sbjct: 438 AINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 484
>CP17A_ICTPU (O73853) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 514 Score = 63.9 bits (154), Expect = 5e-10 Identities = 44/162 (27%), Positives = 81/162 (50%), Gaps = 4/162 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRL- 542 E T+ +L WS+ L +P+ Q ++++E+ + G + P N L + + E LR+ Sbjct: 308 ETTTTVLKWSILYLIHHPQVQRKIQEELDAKIGRDRHPQVNDRGNLPYLEATIREVLRIR 367 Query: 541 -YSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGIT 365 SP L + ++D +G + KG +++ + +H D++ W + + F P RF N Sbjct: 368 PVSP-LLIPHVALSDANIGEYTVQKGTRVIVNLWSLHHDEKEW-KNPELFNPERFLNEEG 425 Query: 364 GAAKVPH-GLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFS 242 + P L F G R C+G+ + LE L+ +LQ+F+ Sbjct: 426 NSLCCPSLSYLPFGAGVRVCLGEALAKLELFLFLSWILQRFT 467
>C11B1_PIG (Q29552) Cytochrome P450 11B1, mitochondrial precursor (EC| 1.14.15.4) (CYPXIB1) (P450C11) (Steroid 11-beta-hydroxylase) Length = 503 Score = 63.9 bits (154), Expect = 5e-10 Identities = 43/158 (27%), Positives = 79/158 (50%), Gaps = 1/158 (0%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPN-ALNKLKEMTMVLFETLRLY 539 + T+ L +++ L+ PE Q+ LR+E L S +P A+ +L + L ETLRLY Sbjct: 317 DTTAYPLLMTLFELARNPEVQQALRQESLAAAARISENPQKAITELPLLRAALKETLRLY 376 Query: 538 SPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGA 359 +F+ R +D+ + + +P G + + + + R+ V+ + + P R+ + Sbjct: 377 PVGIFLDRCVTSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFA-RPERYHPQRWLDNQGSG 435 Query: 358 AKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF 245 + PH LAF G R C+G+ + +E L +L+ F Sbjct: 436 TRFPH--LAFGFGMRQCLGRRLAQVEMLLLLHHVLKNF 471
>CP1A1_MOUSE (P00184) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1)| Length = 524 Score = 63.9 bits (154), Expect = 5e-10 Identities = 44/166 (26%), Positives = 80/166 (48%), Gaps = 3/166 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + + ++WS+ L P Q ++++E+ G + P + +L + + ET R Sbjct: 324 DTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHS 383 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI-T 365 S F + T D ++ +PKG + + ++ D+E+WGD +EF+P RF T Sbjct: 384 SFVPFTIPHSTTRDTSLNGFYIPKGCCVFVNQWQVNHDRELWGDP-NEFRPERFLTPSGT 442 Query: 364 GAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 ++ + F +G R CIG+ E LA++LQ+ F +SP Sbjct: 443 LDKRLSEKVTLFGLGKRKCIGETIGRSEVFLFLAILLQQIEFKVSP 488
>CP1A1_MESAU (Q00557) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P-450MC)| Length = 524 Score = 63.9 bits (154), Expect = 5e-10 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 3/166 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + + ++WS+ L P Q ++++E+ G + P ++L + + ET R Sbjct: 324 DTVTTAISWSLMYLVTNPGVQRKIQEELDTVIGRSRRPRLCDRSQLPYLEAFILETFRHS 383 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 S F + T D ++ +PKG + + ++ ++E+WGD ++F+P RF Sbjct: 384 SFLPFTIPHSTTRDTSLCGFYIPKGHCVFVNQWQINHNQELWGDP-NKFRPERFLTSSGT 442 Query: 361 AAKVPHGLLA-FSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 KV G + F +G R CIG+ LE LA++LQ+ FT+SP Sbjct: 443 LDKVLSGKVTLFGLGKRKCIGETIGRLEVFLFLAILLQQIEFTVSP 488
>C77A2_SOLME (P37124) Cytochrome P450 77A2 (EC 1.14.-.-) (CYPLXXVIIA2)| (P-450EG5) Length = 511 Score = 63.9 bits (154), Expect = 5e-10 Identities = 52/198 (26%), Positives = 90/198 (45%), Gaps = 11/198 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNALNKLKEMTMVLFETLRLYS 536 + T+ + W++ L P Q +L +E+ K G D + K+ + V+ E LR + Sbjct: 318 DTTATAIEWAIGRLIENPNIQSQLYEEIKKTVGENKIDEKDIEKMPYLNAVVKELLRKHP 377 Query: 535 PALFMQRKTVADMT-VGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNG---- 371 P V + +G +P G+ + I +P + D +W + ++F P RF G Sbjct: 378 PTYMSLTHAVTEPAKLGGYDIPTGVNVEIFLPGISDDPNLWSEP-EKFDPDRFYLGKEDA 436 Query: 370 -ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDI-- 200 ITG + V ++ F MG R C G N + + LA ++Q+F + D + VD Sbjct: 437 DITGVSGVK--MIPFGMGRRICPGLNMATVHVSLMLARLVQEFEWA---DPENTRVDFTE 491 Query: 199 ---FTLKPKFGLQVFVRP 155 FT+ K L+ ++P Sbjct: 492 KLEFTVVMKNTLRAKIKP 509
>CP301_DROME (Q9V6D6) Probable cytochrome P450 301a1, mitochondrial precursor| (EC 1.14.-.-) (CYPCCCIA1) Length = 553 Score = 63.5 bits (153), Expect = 6e-10 Identities = 47/180 (26%), Positives = 87/180 (48%), Gaps = 9/180 (5%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDPNA------LNKLKEMTMVLFE 554 + S+ + +Y L+ P Q+++ +E+ + PDPN L+++ + + E Sbjct: 363 DTISMAVCSMLYQLATRPVDQQKVHEELKRLL----PDPNTPLTIPLLDQMHHLKGFIKE 418 Query: 553 TLRLYSPALFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF-- 380 R+YS + R + D + ++PKG+ V P I+ + E + DA F+P R+ Sbjct: 419 VFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFP-TIVTGNMEEYVTDAATFRPERWLK 477 Query: 379 -KNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVD 203 ++G T P L + G R C+G+ F+ LE + LA +L+ + +Y H P+D Sbjct: 478 PQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKL----EYNHKPLD 533
>C86A1_ARATH (P48422) Cytochrome P450 86A1 (EC 1.14.-.-) (CYPLXXXVI)| (P450-dependent fatty acid omega-hydroxylase) Length = 513 Score = 63.5 bits (153), Expect = 6e-10 Identities = 54/203 (26%), Positives = 97/203 (47%), Gaps = 16/203 (7%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKE---VLKEFGMQSPDP--------NALNKLKEMT 569 + +S+ L+W +L+ E + ++ E VLKE + + ++L + Sbjct: 306 DTSSVALSWFFWLVMNNREVETKIVNELSMVLKETRGNDQEKWTEEPLEFDEADRLVYLK 365 Query: 568 MVLFETLRLYSPALFMQRKTVADMTV--GSLKLPKGIAIVIPIPIMHRDKEVWGDDADEF 395 L ETLRLY P++ K V D V +P+G + I + R K +WG+D EF Sbjct: 366 AALAETLRLY-PSVPQDFKYVVDDDVLPDGTFVPRGSTVTYSIYSIGRMKTIWGEDCLEF 424 Query: 394 KPLRFKNGITGAAKVP---HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPD 224 +P R+ + P + +AF+ GPR+C+G++ + + KS + +L ++ P Sbjct: 425 RPERWLTADGERFETPKDGYKFVAFNAGPRTCLGKDLAYNQMKSVASAVLLRYRVFPVPG 484 Query: 223 YVHAPVDIFTLKPKFGLQVFVRP 155 + TL K GL+V+++P Sbjct: 485 HRVEQKMSLTLFMKNGLRVYLQP 507
>CP52I_CANMA (Q12586) Cytochrome P450 52A9 (EC 1.14.14.-) (CYPLIIA9)| (Alkane-inducible P450-ALK5-A) Length = 521 Score = 63.5 bits (153), Expect = 6e-10 Identities = 52/185 (28%), Positives = 85/185 (45%), Gaps = 16/185 (8%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSPDP------NALNKLKEMTMVLFE 554 + T+ LL+++++ L+ PE RLR+E+ +FG+ +L + + + V+ E Sbjct: 320 DTTAGLLSFALFELARNPEVWSRLREEIGDKFGLDEDATIEGISFESLKQCEYLKAVVNE 379 Query: 553 TLRLYSPALFMQRKTVADMTV---------GSLKLPKGIAIVIPIPIMHRDKEVWGDDAD 401 LR+Y R T+ + + KG + I H D +G DA Sbjct: 380 CLRMYPSVPRNFRIATKHTTLPRGGGPDGKDPIFIKKGAVVSYGINSTHLDPMYYGPDAR 439 Query: 400 EFKPLRFKNGITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKF-SFTLSPD 224 F P R+ T K+ L F+ GPR C+GQ F++ EA L M+Q F L+P+ Sbjct: 440 LFNPDRWSKPET--KKLGWAFLPFNGGPRICLGQQFALTEASYVLVRMIQNFKELELTPN 497 Query: 223 YVHAP 209 V+ P Sbjct: 498 TVYPP 502
>CP1A1_LIZAU (O42231) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 63.5 bits (153), Expect = 6e-10 Identities = 53/185 (28%), Positives = 87/185 (47%), Gaps = 4/185 (2%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLY 539 + S L+WSV L YPE QERL +E+ + G+ ++P + N L + + E R Sbjct: 325 DTISTALSWSVMYLVAYPEIQERLYQELKENVGLDRTPVLSDRNNLPLLEAFILEIFRHS 384 Query: 538 SPALF-MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGI-T 365 S F + T D ++ +PK + I ++ D E+W + F P RF + T Sbjct: 385 SFLPFTIPHCTTKDTSLNGYYIPKDTCVFINQWQINHDPELW-KEPSSFNPDRFLSADGT 443 Query: 364 GAAKVP-HGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPVDIFTLK 188 KV ++ F +G R CIG+ + E LA+++QK F + P + + Sbjct: 444 EVNKVDGEKVMVFGLGKRRCIGEVIARNEVYMFLAILIQKLHF------YNLPGEPLDMT 497 Query: 187 PKFGL 173 P++GL Sbjct: 498 PEYGL 502
>CP6D5_DROME (Q9VFP1) Probable cytochrome P450 6d5 (EC 1.14.-.-) (CYPVID5)| Length = 508 Score = 63.5 bits (153), Expect = 6e-10 Identities = 57/195 (29%), Positives = 91/195 (46%), Gaps = 11/195 (5%) Frame = -3 Query: 718 HENTSLLLTWSVYLLSIYPEWQERLRKEVL----KEFGMQSPDPNALNKLKEMTMVLFET 551 +E T+ ++++Y L+ PE E+ +++V K G + D A++ +K + + ET Sbjct: 316 YETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYD--AISDMKYLEACILET 373 Query: 550 LRLYSPALFMQRKTVADMTVGSLKL--PKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF- 380 R Y + R D V KL KG I+I + MHRD+E + D +KP R+ Sbjct: 374 ARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPL-AYKPERYL 432 Query: 379 KNG--ITGAAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSPDYVHAPV 206 +NG T AA +P F GPR CIG + K +A +L F + + Sbjct: 433 ENGKDYTQAAYLP-----FGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEF 487 Query: 205 DIF--TLKPKFGLQV 167 ++ L PK G+ V Sbjct: 488 GVYGIPLMPKSGVPV 502
>C81F1_ARATH (O65790) Cytochrome P450 81F1 (EC 1.14.-.-)| Length = 500 Score = 63.5 bits (153), Expect = 6e-10 Identities = 43/161 (26%), Positives = 79/161 (49%), Gaps = 2/161 (1%) Frame = -3 Query: 715 ENTSLLLTWSVYLLSIYPEWQERLRKEVLKEFGMQSP-DPNALNKLKEMTMVLFETLRLY 539 E +++ L W++ L PE E+ R E+ ++ G D + + L + V+ ET RL+ Sbjct: 303 ETSAVTLEWAMANLLRNPEVLEKARSEIDEKIGKDRLIDESDIAVLPYLQNVVSETFRLF 362 Query: 538 SPALFM-QRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITG 362 A F+ R DM +G +P+ +++ +HRD E+W ++ ++F P R+ +G G Sbjct: 363 PVAPFLIPRSPTDDMKIGGYDVPRDTIVMVNAWAIHRDPEIW-EEPEKFNPDRYNDG-CG 420 Query: 361 AAKVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSF 239 + + L+ F G R+C G L ++Q F + Sbjct: 421 SDYYVYKLMPFGNGRRTCPGAGLGQRIVTLALGSLIQCFEW 461
>CP2D6_HUMAN (P10635) Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1)| (Debrisoquine 4-hydroxylase) Length = 497 Score = 63.5 bits (153), Expect = 6e-10 Identities = 48/180 (26%), Positives = 83/180 (46%), Gaps = 5/180 (2%) Frame = -3 Query: 709 TSLLLTWSVYLLSIYPEWQERLRKEVLKEFG-MQSPDPNALNKLKEMTMVLFETLRLYSP 533 TS L W + L+ ++P+ Q R+++E+ G ++ P+ + T V+ E R Sbjct: 310 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 369 Query: 532 A-LFMQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRFKNGITGAA 356 L + T D+ V ++PKG ++ + + +D+ VW + F P F + G Sbjct: 370 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA-QGHF 427 Query: 355 KVPHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTL---SPDYVHAPVDIFTLKP 185 P L FS G R+C+G+ + +E +LQ FSF++ P H V F + P Sbjct: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSP 487
>CP1A2_MACFU (Q4H4C3) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 63.2 bits (152), Expect = 8e-10 Identities = 45/161 (27%), Positives = 78/161 (48%), Gaps = 4/161 (2%) Frame = -3 Query: 697 LTWSVYLLSIYPEWQERLRKEVLKEFGM-QSPDPNALNKLKEMTMVLFETLRLYSPALF- 524 ++WS+ L PE Q +++KE+ G + P + +L + + ET R S F Sbjct: 325 ISWSLMYLVTKPEIQRKIQKELDAVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFT 384 Query: 523 MQRKTVADMTVGSLKLPKGIAIVIPIPIMHRDKEVWGDDADEFKPLRF--KNGITGAAKV 350 + T D T+ +P+ + I ++ D ++WGD + EF+P RF G T + Sbjct: 385 IPHSTTRDTTLNGFYIPRECCVFINQWQVNHDPQLWGDPS-EFRPERFLTAEGTTINKPL 443 Query: 349 PHGLLAFSMGPRSCIGQNFSMLEAKSTLALMLQKFSFTLSP 227 ++ F +G R CIG+ E LA++LQ+ F++ P Sbjct: 444 SEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLEFSVPP 484 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 107,708,837 Number of Sequences: 219361 Number of extensions: 2277754 Number of successful extensions: 6287 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5589 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5761 length of database: 80,573,946 effective HSP length: 109 effective length of database: 56,663,597 effective search space used: 7366267610 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
